strainid	orf	gene	zyg	qualifier	SGTC_1658|st012944.score	SGTC_1658|st012944.expt.zyg.pval	SGTC_1658|st012944.expt.zyg.significant	SGTC_1658|st012944.expt.zyg.rank	strain.pval	strain.rank	clearance	Fclass	Fterms.BP	Fterms.CC	Fterms.complex	description	GO_process	GO_function	GO_component
YDL226C	YDL226C	GCS1	hom	Verified	13.4506617707537	1.52564613345873e-41	yes	1	7.33343576681037e-30	57	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|SIGNALING|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION	MITOCHONDRION|GOLGI APPARATUS|CYTOSKELETON		ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p	retrograde vesicle-mediated transport, Golgi to ER|Golgi to plasma membrane protein transport|actin filament reorganization involved in cell cycle|ER to Golgi vesicle-mediated transport	actin binding|ARF GTPase activator activity|GTPase activator activity	endosome|trans-Golgi network|endoplasmic reticulum-Golgi intermediate compartment|cytoskeleton
YOR089C	YOR089C	VPS21	hom	Verified	10.3781435352428	1.55889440626458e-25	yes	2	5.24635916993973e-15	7	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|VACUOLAR TRANSPORT	MITOCHONDRION		Rab family GTPase; required for endocytic transport and for sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog; protein abundance increases in response to DNA replication stress; VPS21 has a paralog, YPT53, that arose from the whole genome duplication	endocytosis|vacuole inheritance|protein targeting to vacuole	GTP binding|GTPase activity	mitochondrial outer membrane|late endosome|mitochondrion
YDR203W_d	YDR203W	YDR203W	hom	Dubious	9.7764051963667	7.10852902348344e-23	yes	3	4.52864212837924e-17	4	NA	FF				Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR058W	YMR058W	FET3	hom	Verified	9.21484675820587	1.55861621983924e-20	yes	4	2.15150975352673e-19	6	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS	PLASMA MEMBRANE		Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress	iron assimilation by reduction and transport|high-affinity iron ion transport|response to copper ion	ferroxidase activity|iron ion transmembrane transporter activity	integral to membrane|high affinity iron permease complex|plasma membrane
YDR271C_d	YDR271C	YDR271C	hom	Dubious	9.12685326599571	3.52596024015804e-20	yes	5	2.09482927396301e-15	7	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W	Unknown	Unknown	Unknown
YDR323C	YDR323C	PEP7	hom	Verified	8.8494842483187	4.39623357161188e-19	yes	6	2.88595464179506e-11	22	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT			Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance	Golgi to vacuole transport|vacuole inheritance|vesicle fusion|vesicle docking involved in exocytosis|Golgi to endosome transport	phosphatidylinositol-3-phosphate binding	external side of endosome membrane|cytoplasm
YDL077C	YDL077C	VAM6	hom	Verified	8.81875115307142	5.78716731325434e-19	yes	7	7.94355573955476e-13	16	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION			Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p	regulation of SNARE complex assembly|regulation of vacuole fusion, non-autophagic|piecemeal microautophagy of nucleus|vesicle-mediated transport|vacuole organization|vacuole fusion, non-autophagic	Rab guanyl-nucleotide exchange factor activity|phosphatidylinositol binding	fungal-type vacuole membrane|HOPS complex|fungal-type vacuole
YGR092W	YGR092W	DBF2	hom	Verified	8.52354055548894	7.73742813687218e-18	yes	8	7.86874992236858e-13	10	NA	FF|FT	CELL CYCLE|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS	SITE OF POLARIZED GROWTH|CYTOSKELETON		Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; phosphorylates Chs2p to regulate primary septum formation and Hof1p to regulate cytokinesis	nuclear division|protein phosphorylation|vacuolar acidification	protein serine/threonine kinase activity|protein kinase activity	spindle pole body|cellular bud neck
YMR057C_d	YMR057C	YMR057C	hom	Dubious	8.184114933692	1.3715609141406e-16	yes	9	1.3785634133067e-17	1	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF AAC1	Unknown	Unknown	Unknown
YBR131W	YBR131W	CCZ1	hom	Verified	8.16961593115963	1.54686383954623e-16	yes	10	2.86398766770069e-17	7	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Protein involved in vacuolar assembly, essential for autophagy and the cytoplasm-to-vacuole pathway	autophagy|autophagic vacuole fusion|vacuolar transport|vesicle docking|protein targeting to vacuole	guanyl-nucleotide exchange factor activity	Mon1-Ccz1 complex|membrane
YJR040W	YJR040W	GEF1	hom	Verified	7.65897282165408	9.37130264109955e-15	yes	11	1.1711301333486e-13	14	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOPLASMIC RETICULUM|GOLGI APPARATUS|PLASMA MEMBRANE		Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism	cellular copper ion homeostasis|cellular iron ion homeostasis	voltage-gated chloride channel activity	endosome|integral to membrane|endoplasmic reticulum|Golgi apparatus|plasma membrane|fungal-type vacuole|Golgi medial cisterna
YKL002W	YKL002W	DID4	hom	Verified	7.50582177156252	3.05222131632657e-14	yes	12	1.61000425303234e-12	2	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT			Class E Vps protein of the ESCRT-III complex, required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis	protein retention in Golgi apparatus|intralumenal vesicle formation|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|late endosome to vacuole transport	molecular_function	ESCRT III complex|cytoplasm
YDR270W	YDR270W	CCC2	hom	Verified	7.42410357654525	5.67731405402333e-14	yes	13	5.8957320255261e-12	8	NA	FF|FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism	cellular iron ion homeostasis|copper ion export|transmembrane transport	copper ion binding|cation-transporting ATPase activity	integral to membrane|trans-Golgi network transport vesicle membrane
YML097C	YML097C	VPS9	hom	Verified	7.29685303768872	1.47288121698438e-13	yes	14	1.36070886313622e-12	11	NA	FF|FT	PROTEIN LOCALIZATION|VACUOLAR TRANSPORT			A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin	vacuole inheritance|protein targeting to vacuole	ubiquitin binding|guanyl-nucleotide exchange factor activity	cytosol
YER145C	YER145C	FTR1	hom	Verified	7.17996145609099	3.4865537452741e-13	yes	15	2.6763071742336e-12	5	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		High affinity iron permease; involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron; protein abundance increases in response to DNA replication stress	iron assimilation by reduction and transport|high-affinity iron ion transport|transmembrane transport	iron ion transmembrane transporter activity	high affinity iron permease complex|integral to membrane|plasma membrane
YKR026C	YKR026C	GCN3	hom	Verified	6.99791635544895	1.29898552443559e-12	yes	16	1.41197911525511e-09	74	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION			Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression	regulation of translational initiation	enzyme regulator activity|guanyl-nucleotide exchange factor activity|translation initiation factor activity	eukaryotic translation initiation factor 2B complex|guanyl-nucleotide exchange factor complex
YNR052C	YNR052C	POP2	hom	Verified	6.9782657671094	1.49422970803168e-12	yes	17	1.43748055826186e-08	5	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS|SITE OF POLARIZED GROWTH		RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation	regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|nuclear-transcribed mRNA poly(A) tail shortening|transcription elongation from RNA polymerase II promoter	3'-5'-exoribonuclease activity	CCR4-NOT core complex|mating projection tip|cytoplasmic mRNA processing body|cytoplasm
YDR080W	YDR080W	VPS41	hom	Verified	6.95656983516543	1.74328732299428e-12	yes	18	3.53200527198339e-12	18	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|VACUOLAR PROTEIN PROCESSING			Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport	regulation of SNARE complex assembly|regulation of vacuole fusion, non-autophagic|piecemeal microautophagy of nucleus|vacuole organization|vesicle-mediated transport|protein transport|vacuole fusion, non-autophagic|vacuolar protein processing	Rab guanyl-nucleotide exchange factor activity|phosphatidylinositol binding	endosome|fungal-type vacuole membrane|HOPS complex
YHR004C	YHR004C	NEM1	hom	Verified	6.71610900674796	9.33205967522072e-12	yes	19	1.39680985145386e-10	25	NA	FF|FT	LIPID METABOLISM|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION		Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard	negative regulation of phospholipid biosynthetic process|nuclear envelope organization	phosphoprotein phosphatase activity	Nem1-Spo7 phosphatase complex|mitochondrion|integral to membrane
YLR407W_p	YLR407W	YLR407W	hom	Uncharacterized	6.70718850401736	9.92049464353023e-12	yes	20	9.83515138542017e-12	6	NA					Putative protein of unknown function; null mutant displays elongated buds and a large fraction of budded cells have only one nucleus	biological_process	molecular_function	cellular_component
YMR116C	YMR116C	ASC1	hom	Verified	6.58606692300468	2.25815158647961e-11	yes	21	8.18180896907696e-11	5	NA	FT	SIGNALING|TRANSLATION		RIBOSOME	G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; regulates P-body formation induced by replication stress; represses Gcn4p in the absence of amino acid starvation	negative regulation of translation|glucose mediated signaling pathway|G-protein coupled receptor signaling pathway|invasive growth in response to glucose limitation	G-protein alpha-subunit binding|GDP-dissociation inhibitor activity|signal transducer activity	cytosolic small ribosomal subunit|cytoplasm
YDR455C_d	YDR455C	YDR455C	hom	Dubious	6.58505972444395	2.27351286421266e-11	yes	22	1.07366512803185e-08	53	NA	FF				Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W	Unknown	Unknown	Unknown
YDL185W	YDL185W	VMA1	hom	Verified	6.55063002300389	2.86474230483704e-11	yes	23	4.87589296878193e-07	6	NA	FF|FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM		Subunit A of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease	intron homing|cellular protein metabolic process|vacuolar acidification	endodeoxyribonuclease activity|proton-transporting ATPase activity, rotational mechanism	vacuolar proton-transporting V-type ATPase, V1 domain|fungal-type vacuole membrane
YJL094C	YJL094C	KHA1	hom	Verified	6.52572557246777	3.38365631029098e-11	yes	24	6.24345539611424e-13	11	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION|GOLGI APPARATUS		Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies	monovalent inorganic cation transport	potassium:hydrogen antiporter activity	mitochondrion|integral to membrane|Golgi apparatus
YMR250W	YMR250W	GAD1	hom	Verified	6.40776719490751	7.38330772424284e-11	yes	25	1.91600969472615e-10	1	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|RESPONSE TO OXIDATIVE STRESS			Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress	cellular response to oxidative stress|glutamate catabolic process	calmodulin binding|glutamate decarboxylase activity	cytoplasm
YPR173C	YPR173C	VPS4	hom	Verified	6.39830414369059	7.85560504680533e-11	yes	26	1.46678754559407e-08	16	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|LIPID METABOLISM|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	ENDOPLASMIC RETICULUM		AAA-ATPase involved in multivesicular body (MVB) protein sorting, ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism	late endosome to vacuole transport via multivesicular body sorting pathway|protein retention in Golgi apparatus|intralumenal vesicle formation|protein homooligomerization|sterol metabolic process|late endosome to vacuole transport	ATPase activity|protein homodimerization activity|ATP binding	endosome|endoplasmic reticulum|membrane|cytoplasm
YOR036W	YOR036W	PEP12	hom	Verified	6.09489938836849	5.47531514533493e-10	yes	27	1.77374313898351e-07	30	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	GOLGI APPARATUS		Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin	Golgi to vacuole transport|vacuole inheritance	SNAP receptor activity	endosome|Golgi apparatus
YDL020C	YDL020C	RPN4	hom	Verified	6.06818467775887	6.46820508744374e-10	yes	28	0.00240926842001457	199	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|PROTEOLYSIS	NUCLEUS		Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress	positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance|regulation of DNA repair|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YOL002C	YOL002C	IZH2	hom	Verified	5.97317134156139	1.16342644162955e-09	yes	29	4.79346335441275e-10	14	NA	FT	KETONE METABOLISM|LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc	response to zinc ion|cellular zinc ion homeostasis|response to toxin|cellular lipid metabolic process	protein binding|metal ion binding	integral to membrane|plasma membrane|membrane
YGL124C	YGL124C	MON1	hom	Verified	5.90404499369925	1.77347679024085e-09	yes	30	1.54253170368283e-08	5	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT			Protein required for fusion of cvt-vesicles and autophagosomes with the vacuole; associates, as a complex with Ccz1p, with a perivacuolar compartment; potential Cdc28p substrate	autophagy|vesicle docking|protein targeting to vacuole	molecular_function	cytosol|fungal-type vacuole membrane|Mon1-Ccz1 complex
YDR456W	YDR456W	NHX1	hom	Verified	5.90178046528376	1.79799734465374e-09	yes	31	2.3994543892851e-09	36	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS	GOLGI APPARATUS		Na+/H+ and K+/H+ exchanger, required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion	sodium ion transmembrane transport|potassium ion transmembrane transport|cellular monovalent inorganic cation homeostasis|vacuolar acidification	sodium:hydrogen antiporter activity|potassium:hydrogen antiporter activity	trans-Golgi network|late endosome|fungal-type vacuole membrane|integral to membrane|early endosome
YDR495C	YDR495C	VPS3	hom	Verified	5.89391449486002	1.88576191265328e-09	yes	32	2.70280648560547e-07	24	NA	FF|FT	PROTEIN LOCALIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT			Component of CORVET tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase	vacuole inheritance|vacuolar acidification|protein targeting to vacuole	molecular_function	CORVET complex|cytoplasm
YOR034C-A_p	YOR034C-A	YOR034C-A	hom	Uncharacterized	5.76810779522181	4.00832626576727e-09	yes	33	1.62265886141646e-07	5	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YJL004C	YJL004C	SYS1	hom	Verified	5.66675270501859	7.2764570114322e-09	yes	34	8.67633048790388e-06	52	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation	vesicle organization|Golgi to plasma membrane protein transport|Golgi to endosome transport	molecular_function	trans-Golgi network|integral to membrane|integral to Golgi membrane
YPR036W	YPR036W	VMA13	hom	Verified	5.62382220581641	9.33889444174886e-09	yes	35	6.227683768025e-06	7	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Subunit H of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; serves as an activator or a structural stabilizer of the V-ATPase	vacuolar acidification	proton-transporting ATPase activity, rotational mechanism	vacuolar proton-transporting V-type ATPase, V1 domain|fungal-type vacuole membrane|integral to membrane
YJR083C	YJR083C	ACF4	hom	Verified	5.51639848143928	1.73008607100536e-08	yes	36	2.73228729136217e-09	1	NA					Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization; potential Cdc28p substrate	biological_process	molecular_function	cellular_component
YAL002W	YAL002W	VPS8	hom	Verified	5.50645021728478	1.83070719773815e-08	yes	37	5.02851698461652e-08	16	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	GOLGI APPARATUS		Membrane-binding component of the CORVET complex; involved in endosomal vesicle tethering and fusion in the endosome to vacuole protein targeting pathway; interacts with Vps21p; contains RING finger motif	late endosome to vacuole transport via multivesicular body sorting pathway|protein targeting to vacuole	GTPase binding|protein anchor	late endosome|membrane|CORVET complex
YKL126W	YKL126W	YPK1	hom	Verified	5.47830532333065	2.14709345526077e-08	yes	38	0.00227337977429711	213	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Serine/threonine protein kinase; phosphorylates and downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p (inhibitors of serine:palmitoyl-coenzyme A transferase) by phosphorylation in response to compromised sphingolipid synthesis; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK; YPK1 has a paralog, YPK2, that arose from the whole genome duplication	eisosome assembly|protein autophosphorylation|negative regulation of phospholipid translocation|protein phosphorylation	protein serine/threonine kinase activity	cytosol|plasma membrane|cellular bud neck
YCR094W	YCR094W	CDC50	hom	Verified	5.39503422444628	3.4255246248988e-08	yes	39	5.1873615198493e-06	116	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	GOLGI APPARATUS		Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Lem3p; CDC50 has a paralog, YNR048W, that arose from the whole genome duplication	intracellular protein transport|phospholipid translocation|endocytosis|actin cortical patch localization	phospholipid-translocating ATPase activity	trans-Golgi network|late endosome membrane
YBR164C	YBR164C	ARL1	hom	Verified	5.38931738500304	3.53629026245433e-08	yes	40	3.9816533990896e-05	32	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|VACUOLAR TRANSPORT	GOLGI APPARATUS		Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor	Golgi to plasma membrane protein transport|vesicle-mediated transport|protein targeting to vacuole	GTPase activity	trans-Golgi network|cytosol|Golgi apparatus
YNR005C_d	YNR005C	YNR005C	hom	Dubious	5.2814873028351	6.4069682330466e-08	yes	41	1.30639707366343e-06	7	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR284W	YMR284W	YKU70	hom	Verified	5.24942973315467	7.6285390948306e-08	yes	42	9.64901275266966e-09	5	NA	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING	ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME		Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair	chromatin assembly or disassembly|chromatin silencing|double-strand break repair via nonhomologous end joining|telomere maintenance|double-strand break repair via break-induced replication|double-strand break repair via homologous recombination|chromatin silencing at silent mating-type cassette	damaged DNA binding|RNA binding	nuclear chromatin|nuclear telomeric heterochromatin|nuclear envelope|Ku70:Ku80 complex
YMR214W	YMR214W	SCJ1	hom	Verified	5.18102307144528	1.10336096348905e-07	yes	43	6.08053533096101e-07	14	NA	FT	PROTEIN LOCALIZATION|PROTEOLYSIS	ENDOPLASMIC RETICULUM		One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins	ER-associated protein catabolic process|protein folding in endoplasmic reticulum|response to unfolded protein	chaperone binding	endoplasmic reticulum lumen
YDR285W	YDR285W	ZIP1	hom	Verified	5.13747859321696	1.39224587346984e-07	yes	44	1.84264562160441e-07	4	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Transverse filament protein of the synaptonemal complex; required for normal levels of meiotic recombination and pairing between homologous chromosome during meiosis; potential Cdc28p substrate	synapsis|reciprocal meiotic recombination	chromatin binding|SUMO polymer binding	transverse filament
YKL041W	YKL041W	VPS24	hom	Verified	5.08280957531152	1.85946245857431e-07	yes	45	9.37845443786207e-07	16	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM		One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); forms an ESCRT-III subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway	intralumenal vesicle formation|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|late endosome to vacuole transport	molecular_function	ESCRT III complex|cytoplasm
YJR033C	YJR033C	RAV1	hom	Verified	5.07486203074988	1.9388863192214e-07	yes	46	4.28566041385437e-06	48	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM		Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate	early endosome to late endosome transport|vacuolar acidification|regulation of protein complex assembly	molecular_function	RAVE complex|cytoplasm|extrinsic to membrane
YPL120W	YPL120W	VPS30	hom	Verified	4.92633700458844	4.18927208977746e-07	yes	47	1.38144922705305e-06	21	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION			Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy and Complex II is required for vacuolar protein sorting; required for overflow degradation of misfolded proteins when ERAD is saturated; ortholog of the higher eukaryotic gene Beclin 1	phosphatidylinositol biosynthetic process|piecemeal microautophagy of nucleus|ER-associated protein catabolic process|peroxisome degradation|retrograde transport, endosome to Golgi|macroautophagy|CVT pathway|late endosome to vacuole transport	1-phosphatidylinositol-3-kinase activity	phosphatidylinositol 3-kinase complex I|phosphatidylinositol 3-kinase complex II|extrinsic to membrane|cytoplasm
YDL122W	YDL122W	UBP1	hom	Verified	4.88640764276874	5.13462330119036e-07	yes	48	3.20016013967758e-07	7	NA	FT	PROTEOLYSIS	ENDOPLASMIC RETICULUM		Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains	protein deubiquitination	ubiquitin-specific protease activity	endoplasmic reticulum|cytoplasm
YOR070C	YOR070C	GYP1	hom	Verified	4.87168945752811	5.5323994432705e-07	yes	49	0.000464501611194054	119	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM	MITOCHONDRION|GOLGI APPARATUS		Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion	vesicle-mediated transport	Rab GTPase activator activity	mitochondrion|Golgi apparatus
YGL212W	YGL212W	VAM7	hom	Verified	4.80388291813897	7.78089242931832e-07	yes	50	2.23737025523224e-06	39	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION			Vacuolar SNARE protein; functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding; SNAP-25 homolog; protein abundance increases in response to DNA replication stress	piecemeal microautophagy of nucleus|vacuole fusion, non-autophagic|vesicle fusion	SNAP receptor activity|phosphatidylinositol-3-phosphate binding	SNARE complex|fungal-type vacuole membrane
YJL204C	YJL204C	RCY1	hom	Verified	4.80270149711828	7.8269581162277e-07	yes	51	9.21021860800575e-05	229	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	GOLGI APPARATUS|SITE OF POLARIZED GROWTH		F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth	early endosome to Golgi transport|endocytosis	SNARE binding	endosome|Golgi apparatus|site of polarized growth
YDL118W_d	YDL118W	YDL118W	hom	Dubious	4.77589589437125	8.9454468625559e-07	yes	52	1.8376251433535e-05	51	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Dubious open reading frame, unlikely to encode a protein; overlaps almost completely with YDL119C; mutations that would affect both YDL118W and YDL119C confer defective telomere maintenance and are synthetically sick or lethal with alpha-synuclein	biological_process	molecular_function	cellular_component
YDR186C	YDR186C	YDR186C	hom	Verified	4.76909183618255	9.25291439723952e-07	yes	53	7.10655316322152e-07	12	NA					Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	ribosome|cytoplasm
YML001W	YML001W	YPT7	hom	Verified	4.67999117085133	1.43443635648774e-06	yes	54	3.57792540517842e-07	17	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|VACUOLAR TRANSPORT	MITOCHONDRION		Rab family GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion; interacts with the cargo selection/retromer complex for retrograde sorting; similar to mammalian Rab7	regulation of vacuole fusion, non-autophagic|piecemeal microautophagy of nucleus|vacuole inheritance|Golgi to vacuole transport|vesicle-mediated transport|endocytosis	GTPase activity	mitochondrial outer membrane|fungal-type vacuole
YPR065W	YPR065W	ROX1	hom	Verified	4.64438520634223	1.70545317856052e-06	yes	55	2.7371389551937e-06	22	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS|CHROMOSOME		Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance	negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter in response to stress	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|DNA binding, bending|sequence-specific DNA binding|RNA polymerase II transcription factor recruiting transcription factor activity	nuclear chromatin
YGR261C	YGR261C	APL6	hom	Verified	4.61966885826901	1.92176485423727e-06	yes	56	1.39184822237857e-05	30	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools	vesicle-mediated transport|Golgi to vacuole transport	molecular_function	AP-3 adaptor complex
YDL160C	YDL160C	DHH1	hom	Verified	4.61535777646037	1.96209349944874e-06	yes	57	2.62982353675844e-05	33	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION|RNA LOCALIZATION			Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping; coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, may have a role in mRNA export and translation; C-terminus of Dhh1p interacts with Ngr1p and promotes POR1, but not EDC1 mRNA decay; forms cytoplasmic foci upon DNA replication stress	deadenylation-dependent decapping of nuclear-transcribed mRNA|cell morphogenesis involved in conjugation with cellular fusion|stress granule assembly|cytoplasmic mRNA processing body assembly	protein binding|RNA helicase activity	cytoplasmic mRNA processing body|cytoplasmic stress granule|cytoplasm
YNR006W	YNR006W	VPS27	hom	Verified	4.51606789559019	3.14992365005944e-06	yes	58	8.89953743017025e-05	37	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT			Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p)	protein retention in Golgi apparatus|late endosome to vacuole transport|protein targeting to vacuole	ubiquitin binding|phosphatidylinositol-3-phosphate binding	endosome|ESCRT-0 complex
YOR106W	YOR106W	VAM3	hom	Verified	4.5099262138112	3.24250890226891e-06	yes	59	4.07482117096806e-05	39	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|RESPONSE TO NUTRIENT LEVELS			Syntaxin-like vacuolar t-SNARE that functions with Vam7p in vacuolar protein trafficking; mediates docking/fusion of late transport intermediates with the vacuole; has an acidic di-leucine sorting signal and C-terminal transmembrane region	autophagic vacuole fusion|vesicle fusion with vacuole|piecemeal microautophagy of nucleus|vacuole fusion, non-autophagic|vesicle docking|vesicle fusion	protein homodimerization activity|SNAP receptor activity	SNARE complex|fungal-type vacuole membrane
YLR111W_d	YLR111W	YLR111W	hom	Dubious	4.5096292726041	3.24705061109002e-06	yes	60	1.56567375576958e-05	37	NA	FF				Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKR035W-A	YKR035W-A	DID2	hom	Verified	4.50506547118276	3.31762409867058e-06	yes	61	3.71799905921204e-06	12	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM		Class E protein of the vacuolar protein-sorting (Vps) pathway; binds Vps4p and directs it to dissociate ESCRT-III complexes; forms a functional and physical complex with Ist1p; human ortholog may be altered in breast tumors	late endosome to vacuole transport via multivesicular body sorting pathway|late endosome to vacuole transport|protein targeting to vacuole	molecular_function	late endosome|cytoplasm
YLR220W	YLR220W	CCC1	hom	Verified	4.48342357753116	3.67274584754972e-06	yes	62	1.56176794972523e-06	5	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Putative vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack the ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation; relative distribution to the vacuole decreases upon DNA replication stress	manganese ion transport|cellular calcium ion homeostasis|cellular iron ion homeostasis|cellular manganese ion homeostasis|ferrous iron transport	manganese ion transmembrane transporter activity|ferrous iron transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|Golgi apparatus
YKL098W	YKL098W	MTC2	hom	Verified	4.43855285632506	4.52828725087246e-06	yes	63	2.57296589805915e-05	29	NA					Protein of unknown function; mtc2 is synthetically sick with cdc13-1	biological_process	molecular_function	cellular_component
YDR269C_d	YDR269C	YDR269C	hom	Dubious	4.43342571753884	4.637373600624e-06	yes	64	2.84745052364419e-06	19	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR435C	YDR435C	PPM1	hom	Verified	4.42914745206323	4.73031633127994e-06	yes	65	6.04712746112587e-05	57	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS			Carboxyl methyltransferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits	cellular protein complex assembly|C-terminal protein methylation	protein C-terminal leucine carboxyl O-methyltransferase activity	cellular_component
YLL059C_d	YLL059C	YLL059C	hom	Dubious	4.37512360725678	6.06818435283213e-06	yes	66	3.72273268051065e-05	8	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR486C	YDR486C	VPS60	hom	Verified	4.31521421461065	7.97241043558017e-06	yes	67	1.74149564014697e-05	14	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT			Cytoplasmic and vacuolar membrane protein involved in late endosome to vacuole transport; required for normal filament maturation during pseudohyphal growth; may function in targeting cargo proteins for degradation; interacts with Vta1p	late endosome to vacuole transport via multivesicular body sorting pathway|filamentous growth	molecular_function	fungal-type vacuole membrane|cytoplasm
YPL139C	YPL139C	UME1	hom	Verified	4.2923444388136	8.83982047694417e-06	yes	68	9.38446366567578e-06	17	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Negative regulator of meiosis, required for repression of a subset of meiotic genes during vegetative growth, binding of histone deacetylase Rpd3p required for activity, contains a NEE box and a WD repeat motif; homologous with Wtm1p, Wtm2p	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of transcription from RNA polymerase I promoter|negative regulation of chromatin silencing at telomere|positive regulation of transcription from RNA polymerase II promoter|regulation of meiosis	transcription corepressor activity	Rpd3S complex|Rpd3L-Expanded complex|nucleus|Rpd3L complex
YDR283C	YDR283C	GCN2	hom	Verified	4.22884738270113	1.17445806737243e-05	yes	69	0.000464466614165791	169	NA	FF|FT	KETONE METABOLISM|CELL CYCLE|AMINO ACID METABOLISM|RESPONSE TO DNA DAMAGE|TRANSLATION|PROTEIN PHOSPHORYLATION		RIBOSOME	Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control	cellular amino acid biosynthetic process|protein phosphorylation|regulation of translational initiation|DNA damage checkpoint	protein homodimerization activity|protein kinase activity|eukaryotic translation initiation factor 2alpha kinase activity	cytosolic ribosome
YHR104W	YHR104W	GRE3	hom	Verified	4.19010736844856	1.39411244523561e-05	yes	70	1.03491516024233e-05	12	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Aldose reductase; involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress	galactose catabolic process|cellular response to oxidative stress|arabinose catabolic process|D-xylose catabolic process|response to stress	D-xylose:NADP reductase activity|mRNA binding|glucose 1-dehydrogenase (NADP+) activity|alditol:NADP+ 1-oxidoreductase activity	nucleus|cytoplasm
YBR288C	YBR288C	APM3	hom	Verified	4.13271662636699	1.79250307151707e-05	yes	71	8.84898896707664e-05	35	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway	Golgi to vacuole transport|vesicle-mediated transport	molecular_function	AP-3 adaptor complex
YPR129W	YPR129W	SCD6	hom	Verified	4.12083819050326	1.88748246209646e-05	yes	72	9.82543086269542e-05	13	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION			Repressor of translation initiation; binds eIF4G through its RGG domain and inhibits recruitment of the preinitiation complex; also contains an Lsm domain; may have a role in RNA processing; overproduction suppresses null mutation in clathrin heavy chain gene CHC1; forms cytoplasmic foci upon DNA replication stress	stress granule assembly|negative regulation of translational initiation|cytoplasmic mRNA processing body assembly	mRNA binding|RNA binding|eukaryotic initiation factor 4G binding	cytoplasmic mRNA processing body|cytoplasmic stress granule|cytoplasm
YER123W	YER123W	YCK3	hom	Verified	4.11897886675367	1.90277521327089e-05	yes	73	0.000121049263483199	16	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN PHOSPHORYLATION	ENDOMEMBRANE SYSTEM|NUCLEUS|PLASMA MEMBRANE		Palmitoylated, vacuolar membrane-localized casein kinase I isoform; negatively regulates vacuole fusion during hypertonic stress via phosphorylation of Vps41p; shares essential functions with Hrr25p; regulates vesicle fusion in AP-3 pathway	vesicle-mediated transport|protein phosphorylation	protein serine/threonine kinase activity|protein kinase activity	fungal-type vacuole membrane|plasma membrane|nucleus|fungal-type vacuole
YDL100C	YDL100C	GET3	hom	Verified	4.07769094469937	2.27425858053568e-05	yes	74	0.00105762836763061	71	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|NUCLEOTIDE METABOLISM	ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity; protein abundance increases in response to DNA replication stress	retrograde vesicle-mediated transport, Golgi to ER|pheromone-dependent signal transduction involved in conjugation with cellular fusion|response to heat|protein insertion into ER membrane|response to metal ion|posttranslational protein targeting to membrane	ATPase activity|guanyl-nucleotide exchange factor activity	endoplasmic reticulum|GET complex
YJL154C	YJL154C	VPS35	hom	Verified	4.05008261267354	2.55997773473931e-05	yes	75	0.000293866718558462	81	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM		Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p	protein retention in Golgi apparatus|retrograde transport, endosome to Golgi	protein transporter activity	endosome|retromer complex, inner shell|retromer complex
YNL334C	YNL334C	SNO2	hom	Verified	4.04748038875458	2.58859590635887e-05	yes	76	3.30505761226214e-05	11	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Protein of unknown function, nearly identical to Sno3p; expression is induced before the diauxic shift and also in the absence of thiamin	pyridoxine metabolic process|thiamine biosynthetic process	molecular_function	cellular_component
YLR268W	YLR268W	SEC22	hom	Verified	4.01750660117447	2.94085941053329e-05	yes	77	0.00105168095030726	80	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog	retrograde vesicle-mediated transport, Golgi to ER|ER to Golgi vesicle-mediated transport|vesicle fusion with Golgi apparatus|vesicle fusion with endoplasmic reticulum|vesicle fusion	SNAP receptor activity	SNARE complex|integral to membrane|Golgi apparatus|endoplasmic reticulum|ER to Golgi transport vesicle membrane
YGR144W	YGR144W	THI4	hom	Verified	3.99963132327303	3.1720618320582e-05	yes	78	0.00010037843802162	14	NA	FT	MITOCHONDRION ORGANIZATION	NUCLEUS		Thiazole synthase, abundant protein involved in the formation of the thiazole moiety of thiamine during thiamine biosynthesis; acts more as a co-substrate rather than an enzyme by providing the sulphur source for thiazole formation; undergoes a single turnover only; required for mitochondrial genome stability in response to DNA damaging agents	thiamine biosynthetic process|mitochondrial genome maintenance|thiazole biosynthetic process	ferrous iron binding	cytosol
YAL021C	YAL021C	CCR4	hom	Verified	3.98133157712395	3.42651358562256e-05	yes	79	0.000544236317813983	72	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RNA PROCESSING	NUCLEUS	RNA POL II, HOLOENZYME	Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening	regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|DNA replication checkpoint|nuclear-transcribed mRNA poly(A) tail shortening|traversing start control point of mitotic cell cycle|replication fork protection|transcription elongation from RNA polymerase II promoter|DNA replication	3'-5'-exoribonuclease activity	CCR4-NOT core complex|cytoplasmic mRNA processing body|Cdc73/Paf1 complex|cytoplasm
YDR202C	YDR202C	RAV2	hom	Verified	3.96683793464825	3.64162405110874e-05	yes	80	0.000210357870856083	33	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS			Subunit of RAVE (Rav1p, Rav2p, Skp1p), a complex that associates with the V1 domain of the vacuolar membrane (H+)-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme	vacuolar acidification|regulation of protein complex assembly	molecular_function	RAVE complex
YDR481C	YDR481C	PHO8	hom	Verified	3.82250869986398	6.60504081782009e-05	yes	81	6.45620998370707e-05	13	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			Repressible vacuolar alkaline phosphatase; regulated by levels of Pi and by Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides; contributes to NAD+ metabolism by producing nicotinamide riboside from NMN	nicotinamide nucleotide metabolic process|protein dephosphorylation	nucleotide phosphatase activity|alkaline phosphatase activity	fungal-type vacuole membrane
YHR012W	YHR012W	VPS29	hom	Verified	3.80545120185499	7.07729600540549e-05	yes	82	0.000239713695214801	67	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM		Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval	retrograde transport, endosome to Golgi	protein transporter activity	endosome|retromer complex, inner shell|retromer complex
YKR035C_d	YKR035C	OPI8	hom	Dubious	3.71833142156581	0.000100271526872987	yes	83	0.000724729244095922	27	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene DID2/YKR035W-A	Unknown	Unknown	Unknown
YMR123W	YMR123W	PKR1	hom	Verified	3.66206184716857	0.000125096717595223	yes	84	0.00241153342154163	84	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		V-ATPase assembly factor; functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); protein abundance increases in response to DNA replication stress	vacuolar proton-transporting V-type ATPase complex assembly	molecular_function	integral to endoplasmic reticulum membrane
YDR354W	YDR354W	TRP4	hom	Verified	3.65707060156237	0.000127557065176529	yes	85	0.0472194742407375	432	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis	tryptophan biosynthetic process	anthranilate phosphoribosyltransferase activity	nucleus|cytoplasm
YKL121W_p	YKL121W	DGR2	hom	Uncharacterized	3.6280986984444	0.000142758058861097	yes	86	0.000177081976597229	29	NA					Protein of unknown function; null mutant is resistant to 2-deoxy-D-glucose and displays abnormally elongated buds	biological_process	molecular_function	cellular_component
YGL252C	YGL252C	RTG2	hom	Verified	3.61334749196352	0.000151134587154635	yes	87	0.000598914641349602	26	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|SIGNALING|RESPONSE TO NUTRIENT LEVELS	NUCLEUS|CHROMOSOME	HISTONE ACETYLTRANSFERASE	Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p	maintenance of DNA trinucleotide repeats|regulation of transcription from RNA polymerase II promoter|Unknown|nitrogen catabolite regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|mitochondria-nucleus signaling pathway|transcription factor import into nucleus	RNA polymerase II transcription factor binding transcription factor activity	SLIK (SAGA-like) complex|transcriptionally active chromatin|cytoplasm
YDL073W_p	YDL073W	YDL073W	hom	Uncharacterized	3.59835054776917	0.000160120895276446	yes	88	0.000591976507243609	25	NA					Putative protein of unknown function; YDL073W is not an essential gene	biological_process	molecular_function	cellular_component
YPL051W	YPL051W	ARL3	hom	Verified	3.57562822004699	0.000174693940822252	yes	89	0.00116188973809088	102	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor	intracellular protein transport|Golgi to plasma membrane protein transport|protein localization to organelle	GTPase activity	Golgi apparatus|nuclear outer membrane-endoplasmic reticulum membrane network
YPR064W_d	YPR064W	YPR064W	hom	Dubious	3.55867879102033	0.000186362513898887	yes	90	0.000256929710581492	30	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR220C_d	YDR220C	YDR220C	hom	Dubious	3.49456138516726	0.000237420700516701	yes	91	6.98119609851483e-05	12	NA					Dubious open reading frame, null mutant exhibits synthetic phenotype with alpha-synuclein	Unknown	Unknown	Unknown
YLR386W	YLR386W	VAC14	hom	Verified	3.49248175605695	0.000239277142694217	yes	92	0.00127802517809065	52	NA	FT	PROTEIN LOCALIZATION|LIPID METABOLISM			Protein involved in regulated synthesis of PtdIns(3,5)P(2), in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; interacts with Fig4p; activator of Fab1p	phosphatidylinositol biosynthetic process|positive regulation of kinase activity	protein binding, bridging	fungal-type vacuole membrane|PAS complex|extrinsic to vacuolar membrane
YMR067C	YMR067C	UBX4	hom	Verified	3.42855998926193	0.000303396208691953	yes	93	0.000853479287218448	60	NA	FT	PROTEOLYSIS	NUCLEUS		UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the Cdc48p-Nplp-Ufd1p AAA ATPase complex during its role in delivery of misfolded proteins to the proteasome; protein abundance increases in response to DNA replication stress	ER-associated protein catabolic process|sporulation resulting in formation of a cellular spore	protein complex binding	nucleus|cytoplasm|extrinsic to membrane
YKL007W	YKL007W	CAP1	hom	Verified	3.40556550343276	0.000330135858452043	yes	94	0.000405575481919445	43	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Alpha subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress	barbed-end actin filament capping	actin filament binding	actin filament|F-actin capping protein complex|mating projection tip|actin cortical patch
YPL084W	YPL084W	BRO1	hom	Verified	3.31646787062157	0.000455815344886627	yes	95	0.000557799606735643	55	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes	protein deubiquitination|vacuolar transport|protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|response to nutrient|ubiquitin-dependent protein catabolic process	ubiquitin-specific protease activity	endosome|cytoplasm
YGL020C	YGL020C	GET1	hom	Verified	3.29860522130632	0.000485832281862698	yes	96	0.00220992750785471	90	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS		Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance	retrograde vesicle-mediated transport, Golgi to ER|protein insertion into ER membrane	protein anchor	mitochondrion|integral to membrane|endoplasmic reticulum|GET complex
YGR126W_p	YGR126W	YGR126W	hom	Uncharacterized	3.28584103602431	0.000508391870551001	yes	97	0.00025790301315912	24	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	nucleus|cytoplasm
YDR072C	YDR072C	IPT1	hom	Verified	3.26125186809406	0.000554607328647808	yes	98	0.000542118557957099	68	NA	FT	LIPID METABOLISM			Inositolphosphotransferase, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin	mannosyl diphosphorylinositol ceramide metabolic process|sphingolipid biosynthetic process	transferase activity, transferring phosphorus-containing groups	integral to membrane
YDL119C_p	YDL119C	YDL119C	hom	Uncharacterized	3.23904875445295	0.000599645355958785	yes	99	0.00109185926303107	94	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Putative mitochondrial transport protein; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in purified mitochondria	transport	transporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YPL164C	YPL164C	MLH3	hom	Verified	3.22993112221385	0.000619100219386886	yes	100	0.000556804785527626	27	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Protein involved in DNA mismatch repair and crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian microsatellite instability	mismatch repair|reciprocal meiotic recombination	molecular_function	nucleus|MutLbeta complex
YJR105W	YJR105W	ADO1	hom	Verified	3.21180127017246	0.000659527930087448	yes	101	0.00827056332624963	132	NA	FF|FT	NUCLEOTIDE METABOLISM	NUCLEUS		Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle	purine nucleobase metabolic process	adenosine kinase activity	nucleus|cytoplasm
YDR008C_d	YDR008C	YDR008C	hom	Dubious	3.19238144301698	0.00070552428620334	yes	102	0.0536185531174474	464	NA	FF				Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOR332W	YOR332W	VMA4	hom	Verified	3.18175010745404	0.000731940330613907	yes	103	0.00120323296640514	35	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Subunit E of the V1 domain of the vacuolar H+-ATPase (V-ATPase); V-ATPase is an electrogenic proton pump found throughout the endomembrane system; V1 domain has eight subunits; required for the V1 domain to assemble onto the vacuolar membrane; protein abundance increases in response to DNA replication stress	vacuolar acidification	proton-transporting ATPase activity, rotational mechanism	vacuolar proton-transporting V-type ATPase, V1 domain|fungal-type vacuole membrane|integral to membrane
YLR037C	YLR037C	PAU23	hom	Verified	3.16279678997934	0.000781306825947721	yes	104	0.000830637992130092	33	NA	FT	CELL WALL ORG/BIOGENESIS			Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth	biological_process	molecular_function	fungal-type cell wall
YDR335W	YDR335W	MSN5	hom	Verified	3.16208497296111	0.000783219240053971	yes	105	0.00150288693436039	54	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	NUCLEUS		Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm	tRNA re-export from nucleus|protein export from nucleus	protein binding|importin-alpha export receptor activity	integral to membrane|nucleus|cytoplasm
YGR020C	YGR020C	VMA7	hom	Verified	3.13077314092738	0.000871733920479381	yes	106	0.00572960630097516	90	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane	vacuolar acidification	proton-transporting ATPase activity, rotational mechanism	fungal-type vacuole membrane|vacuolar proton-transporting V-type ATPase, V1 domain|integral to membrane
YMR221C_p	YMR221C	YMR221C	hom	Uncharacterized	3.11952939308811	0.000905700936249712	yes	107	0.000518993765455476	31	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; physical interaction with Atg27p suggests a possible role in autophagy	biological_process	molecular_function	mitochondrion|integral to membrane|fungal-type vacuole
YKR014C	YKR014C	YPT52	hom	Verified	3.07026212598837	0.00106935487892497	no	108	0.0015807389131116	51	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|VACUOLAR TRANSPORT	ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Rab family GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; protein abundance increases in response to DNA replication stress	endocytosis|protein targeting to vacuole	GTPase activity	late endosome
YLR413W_p	YLR413W	YLR413W	hom	Uncharacterized	3.06663252666801	0.00108242408955164	no	109	0.000920411572549085	35	NA	FT		PLASMA MEMBRANE		Putative protein of unknown function; YLR413W is not an essential gene	biological_process	molecular_function	integral to membrane
YDR255C	YDR255C	RMD5	hom	Verified	3.04880335658498	0.00114877408628968	no	110	0.000604647768068938	39	NA	FT	KETONE METABOLISM|CELL CYCLE|CARBOHYDRATE METABOLISM|PROTEOLYSIS			Component of GID Complex that confers ubiquitin ligase (U3) activity; necessary for polyubiquitination and degradation of the gluconeogenic enzyme fructose-1,6-bisphosphatase; forms dimer with Fyv10p that is then recruited to GID Complex by Gid8p; also required for sporulation; conserved protein that has a degenerate RING finger domain	negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity	cytosol|GID complex
YER031C	YER031C	YPT31	hom	Verified	3.04208016130022	0.00117474658164104	no	111	0.00682580718374158	177	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING	ENDOMEMBRANE SYSTEM|MITOCHONDRION|GOLGI APPARATUS		Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication	early endosome to Golgi transport|vesicle-mediated transport|exocytosis	GTPase activity	mitochondrial outer membrane|endosome|Golgi apparatus
YOR024W_d	YOR024W	YOR024W	hom	Dubious	3.02405817555794	0.00124704236874333	no	112	0.0010399881295263	25	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGR201C_p	YGR201C	YGR201C	hom	Uncharacterized	3.01025307207852	0.00130515048815232	no	113	0.000467233310884246	22	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YHR192W	YHR192W	LNP1	hom	Verified	3.00569699214655	0.00132486449517252	no	114	0.00410553526564562	40	NA					Lunapark family member involved in ER network formation; localizes to ER junctions and this localization is regulated by the yeast atlastin ortholog Sey1p; interacts with the reticulon protein Rtn1p; induced in response to the DNA-damaging agent MMS	endoplasmic reticulum tubular network organization	molecular_function	endoplasmic reticulum tubular network|cytoplasm
YPR124W	YPR124W	CTR1	hom	Verified	3.00081637224454	0.00134628442087973	no	115	0.0197099410574643	202	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		High-affinity copper transporter of the plasma membrane; mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels; protein increases in abundance and relocalizes from nucleus to plasma membrane upon DNA replication stress	copper ion import	copper uptake transmembrane transporter activity	integral to membrane|plasma membrane
YOR093C_p	YOR093C	YOR093C	hom	Uncharacterized	2.99923488999464	0.00135329277740178	no	116	0.000215538986532557	9	NA	FT		NUCLEUS		Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents	biological_process	molecular_function	integral to membrane
YER101C	YER101C	AST2	hom	Verified	2.98893328293871	0.00139976627065043	no	117	0.0013529922539253	52	NA	FT	PROTEIN LOCALIZATION|OXIDATION-REDUCTION PROCESS			Lipid raft associated protein; overexpression restores Pma1p localization to lipid rafts which is required for targeting of Pma1p to the plasma membrane; sometimes classified in the medium-chain dehydrogenase/reductases (MDRs) superfamily; AST2 has a paralog, AST1, that arose from the whole genome duplication	protein targeting to membrane	molecular_function	cytoplasm
YDR222W_p	YDR222W	YDR222W	hom	Uncharacterized	2.98092200964726	0.00143690985581153	no	118	0.00328273099967461	58	NA	FT	RESPONSE TO OXIDATIVE STRESS			Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	biological_process	molecular_function	cytoplasm
YMR202W	YMR202W	ERG2	hom	Verified	2.92535353325734	0.00172032549150561	no	119	0.0374779294980679	424	NA	FF|FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis	ergosterol biosynthetic process	C-8 sterol isomerase activity	endoplasmic reticulum
YGR181W	YGR181W	TIM13	hom	Verified	2.9200913371136	0.00174964404934177	no	120	0.000360606832903842	27	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial intermembrane space protein, forms a complex with Tim8p that delivers a subset of hydrophobic proteins to the TIM22 complex for insertion into the inner membrane	protein import into mitochondrial inner membrane	protein transporter activity	mitochondrion|integral to membrane|mitochondrial intermembrane space protein transporter complex|mitochondrial intermembrane space
YDR409W	YDR409W	SIZ1	hom	Verified	2.88244559566191	0.00197300635717503	no	121	0.0021566195619613	38	NA	FT	CHROMOSOME SEGREGATION	NUCLEUS|SITE OF POLARIZED GROWTH|CHROMOSOME|CYTOSKELETON		SUMO/Smt3 ligase that promotes the attachment of sumo (Smt3p; small ubiquitin-related modifier) to proteins; binds Ubc9p and may bind septins; specifically required for sumoylation of septins in vivo; localized to the septin ring	protein sumoylation|chromosome segregation	SUMO ligase activity	nuclear chromatin|septin ring
YHR026W	YHR026W	VMA16	hom	Verified	2.87769712461809	0.00200294771591913	no	122	0.0133046299096559	114	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Subunit c'' of the vacuolar ATPase, which functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domain	vacuolar acidification	proton-transporting ATPase activity, rotational mechanism	vacuolar proton-transporting V-type ATPase, V0 domain|integral to membrane
YDL192W	YDL192W	ARF1	hom	Verified	2.86234511735571	0.00210259366824959	no	123	0.00549118080375666	113	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|RESPONSE TO NUTRIENT LEVELS	GOLGI APPARATUS		ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication	ER to Golgi vesicle-mediated transport|Golgi to plasma membrane transport|intra-Golgi vesicle-mediated transport|macroautophagy	GTPase activity	cytosol|Golgi-associated vesicle
YPL006W	YPL006W	NCR1	hom	Verified	2.83221735496926	0.0023113207087808	no	124	0.00250994291096984	44	NA	FT	LIPID METABOLISM			Vacuolar membrane protein that transits through the biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism; glycoprotein and functional orthologue of human Niemann Pick C1 (NPC1) protein	sphingolipid metabolic process	sphingolipid transporter activity	fungal-type vacuole membrane|integral to membrane
YLR395C	YLR395C	COX8	hom	Verified	2.82378234167631	0.00237303016690175	no	125	0.00468666454576403	49	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YPR050C_d	YPR050C	YPR050C	hom	Dubious	2.80727835161279	0.00249810246679252	no	126	0.00768784813714311	85	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MAK3/YPR051W	Unknown	Unknown	Unknown
YGL095C	YGL095C	VPS45	hom	Verified	2.76550514165998	0.00284173545402915	no	127	0.03306996946938	270	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment	vacuole inheritance|CVT pathway|positive regulation of SNARE complex assembly|Golgi vesicle fusion to target membrane|Golgi to vacuole transport|vacuole organization|vacuolar acidification|protein targeting to vacuole|Golgi to endosome transport	unfolded protein binding|SNARE binding	cytosol|SNARE complex|Golgi membrane|extrinsic to membrane
YBR105C	YBR105C	VID24	hom	Verified	2.75594350658804	0.00292615519886603	no	128	0.00429849461893935	58	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|KETONE METABOLISM|MEMBRANE ORGANIZATION|CARBOHYDRATE METABOLISM|PROTEOLYSIS|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM		GID Complex regulatory subunit; binds GID Complex in response to glucose through interactions with complex member Vid28p; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; promotes proteasome-dependent catabolite degradation of FBPase; peripheral membrane protein located at Vid (vacuole import and degradation) vesicles	negative regulation of gluconeogenesis|vesicle fusion with vacuole|vacuolar protein catabolic process|proteasomal ubiquitin-dependent protein catabolic process|vesicle-mediated transport|protein targeting to vacuole	molecular_function	cytoplasmic membrane-bounded vesicle|GID complex|extrinsic to membrane
YPL195W	YPL195W	APL5	hom	Verified	2.73973065277289	0.0030744776389443	no	129	0.00752732916578408	105	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Delta adaptin-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function	vesicle-mediated transport|Golgi to vacuole transport	protein binding	AP-3 adaptor complex
YDR006C	YDR006C	SOK1	hom	Verified	2.73736435055116	0.0030966828178446	no	130	0.00198123043236059	26	NA	FT	SIGNALING	NUCLEUS		Protein whose overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13	cAMP-mediated signaling	molecular_function	nucleus
YCR105W	YCR105W	ADH7	hom	Verified	2.71400271449792	0.00332378107495871	no	131	0.00684735426968291	48	NA	FT	OXIDATION-REDUCTION PROCESS			NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance	alcohol metabolic process	alcohol dehydrogenase (NADP+) activity	cellular_component
YOL091W	YOL091W	SPO21	hom	Verified	2.7100870598093	0.00336327747825478	no	132	0.00236696280794513	54	NA	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION	CYTOSKELETON		Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation	ascospore wall assembly|meiosis	structural molecule activity	spindle pole body
YJL064W_d	YJL064W	YJL064W	hom	Dubious	2.70961766466542	0.0033680403774166	no	133	0.00278795345795213	51	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL065C/DLS1	Unknown	Unknown	Unknown
YMR279C	YMR279C	YMR279C	hom	Verified	2.69824137272335	0.00348534391261819	no	134	0.00693187463523209	66	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Putative boron transporter involved in boron efflux and resistance; overexpression mutant but not null mutant displays boron tolerance phenotype; identified as a heat-induced gene in a high-throughout screen; YMR279C is not an essential gene; YMR279C has a paralog, ATR1, that arose from the whole genome duplication	borate transmembrane transport	borate efflux transmembrane transporter activity	integral to membrane
YDR092W	YDR092W	UBC13	hom	Verified	2.69581238944233	0.00351086012567802	no	135	0.00161584124395954	53	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE	NUCLEUS		Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus	postreplication repair|protein monoubiquitination|protein polyubiquitination|free ubiquitin chain polymerization	ubiquitin-protein ligase activity	ubiquitin conjugating enzyme complex|nucleus|cytoplasm
YER083C	YER083C	GET2	hom	Verified	2.68694505168122	0.00360544069944846	no	136	0.0250062968752619	224	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for meiotic nuclear division	retrograde vesicle-mediated transport, Golgi to ER|protein insertion into ER membrane	protein anchor	integral to membrane|endoplasmic reticulum|GET complex
YBR035C	YBR035C	PDX3	hom	Verified	2.68525953137334	0.00362367526548166	no	137	0.00257093632083135	84	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM			Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism	fatty acid metabolic process	pyridoxamine-phosphate oxidase activity	cellular_component
YOR069W	YOR069W	VPS5	hom	Verified	2.68314265920876	0.00364669357003376	no	138	0.00571674871121587	82	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Nexin-1 homolog required for localizing membrane proteins from a prevacuolar/late endosomal compartment back to the late Golgi apparatus; structural component of the retromer membrane coat complex; forms a retromer subcomplex with Vps17p; required for recruiting the retromer complex to the endosome membranes	protein retention in Golgi apparatus|retrograde transport, endosome to Golgi	protein transporter activity|phosphatidylinositol-3-phosphate binding	cytosol|endosome|retromer complex, outer shell|retromer complex
YDR057W	YDR057W	YOS9	hom	Verified	2.67970821044621	0.00368431805531966	no	139	0.00289223501022046	32	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	UBIQUITIN LIGASE COMPLEX	ER quality-control lectin; integral subunit of the HRD ligase; binds to glycans with terminal alpha-1,6 linked mannose on misfolded N-glycosylated proteins and participates in targeting proteins to ERAD; member of the OS-9 protein family	ER-associated protein catabolic process	oligosaccharide binding	luminal surveillance complex|Hrd1p ubiquitin ligase ERAD-L complex|endoplasmic reticulum lumen
YPL103C	YPL103C	FMP30	hom	Verified	2.66672620870672	0.00382970208119993	no	140	0.00331965076161258	60	NA	FT	LIPID METABOLISM	MITOCHONDRION		Mitochondrial inner membrane protein with a role in maintaining mitochondrial morphology and normal cardiolipin levels; proposed to be involved in N-acylethanolamine metabolism; related to mammalian N-acylPE-specific phospholipase D	N-acylphosphatidylethanolamine metabolic process|N-acylethanolamine metabolic process	NAPE-specific phospholipase D activity	mitochondrion|integral to mitochondrial inner membrane
YFR010W	YFR010W	UBP6	hom	Verified	2.65597604660979	0.00395396156077986	no	141	0.014637663951772	107	NA	FT	PROTEOLYSIS			Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains; works in opposition to Hul5p polyubiquitin elongation activity; mutant has aneuploidy tolerance	protein deubiquitination	ubiquitin-specific protease activity	proteasome complex|proteasome regulatory particle
YPL069C	YPL069C	BTS1	hom	Verified	2.65011255624391	0.00402324794530677	no	142	0.0646447869493471	385	NA	FF|FT	PROTEIN LOCALIZATION|LIPID METABOLISM	MITOCHONDRION		Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic	terpenoid biosynthetic process	farnesyltranstransferase activity	mitochondrion
YDR248C_p	YDR248C	YDR248C	hom	Uncharacterized	2.64701657081056	0.00406026868452955	no	143	0.00211908096221333	46	NA	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM			Putative gluconokinase; sequence similarity to bacterial and human gluconokinase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; upregulated by deletion of the RNAP-II associated factor, PAF1	biological_process	molecular_function	cytoplasm
YOR068C	YOR068C	VAM10	hom	Verified	2.63945846690811	0.00415192987408487	no	144	0.00542713502163404	88	NA	FT	MEMBRANE ORGANIZATION			Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering	vacuole fusion, non-autophagic	molecular_function	fungal-type vacuole membrane
YDR406W	YDR406W	PDR15	hom	Verified	2.63313092501374	0.00423008640671501	no	145	0.00279834468950316	41	NA	FT	NUCLEOTIDE METABOLISM			Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element	transport|response to drug	ATPase activity, coupled to transmembrane movement of substances	integral to membrane
YPR130C_d	YPR130C	YPR130C	hom	Dubious	2.62803272799822	0.00429401263496199	no	146	0.00501962028735714	73	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGR146C	YGR146C	ECL1	hom	Verified	2.6044746017146	0.00460076202702206	no	147	0.00518296878827213	78	NA					Protein of unknown function; mitochondrial-dependent role in the extension of chronological lifespan; overexpression increases oxygen consumption and respiratory activity while deletion results in reduced oxygen consumption under conditions of caloric restriction; induced by iron homeostasis transcription factor Aft2p; multicopy suppressor of temperature sensitive hsf1 mutant; induced by treatment with 8-methoxypsoralen and UVA irradiation	biological_process	molecular_function	cellular_component
YMR071C	YMR071C	TVP18	hom	Verified	2.59899272374551	0.00467488775518644	no	148	0.0127014806311293	171	NA	FF|FT	VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments	vesicle-mediated transport	molecular_function	integral to membrane|integral to Golgi membrane|clathrin-coated vesicle
YHR063C	YHR063C	PAN5	hom	Verified	2.58473669368737	0.00487266943761955	no	149	0.00657076536643768	57	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM			2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panE	pantothenate biosynthetic process	2-dehydropantoate 2-reductase activity	cytoplasm
YLR232W_d	YLR232W	YLR232W	hom	Dubious	2.58381957969552	0.00488564472653621	no	150	0.00279050969725483	46	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene BNA5	Unknown	Unknown	Unknown
YKL212W	YKL212W	SAC1	hom	Verified	2.58095907854647	0.00492631299693388	no	151	0.0436136435466214	346	NA	FF|FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS		Phosphatidylinositol phosphate (PtdInsP) phosphatase; involved in hydrolysis of PtdIns[4]P in the early and medial Golgi; regulated by interaction with Vps74p; ER localized transmembrane protein which cycles through the Golgi; involved in protein trafficking and processing, secretion, and cell wall maintenance; regulates sphingolipid biosynthesis through the modulation of PtdIns(4)P metabolism	phosphatidylinositol dephosphorylation	phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity|phosphatidylinositol-3-phosphatase activity|phosphatidylinositol-4-phosphate phosphatase activity	mitochondrial outer membrane|integral to endoplasmic reticulum membrane|mitochondrion|SPOTS complex|integral to Golgi membrane
YAL049C	YAL049C	AIM2	hom	Verified	2.57787075953442	0.00497055856740124	no	152	0.00333378990778596	49	NA					Cytoplasmic protein involved in mitochondrial function or organization; null mutant displays reduced frequency of mitochondrial genome loss; potential Hsp82p interactor	biological_process	molecular_function	cytoplasm
YHR140W_p	YHR140W	YHR140W	hom	Uncharacterized	2.54704265378327	0.00543200766521602	no	153	0.00286412798526102	37	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative integral membrane protein of unknown function	biological_process	molecular_function	integral to membrane
YBL079W	YBL079W	NUP170	hom	Verified	2.54536881220976	0.0054581186708333	no	154	0.011130798759521	148	NA	FF|FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA LOCALIZATION|CHROMOSOME SEGREGATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication	nucleocytoplasmic transport|chromosome segregation|protein targeting to nuclear inner membrane|mitotic cell cycle spindle assembly checkpoint|nuclear pore complex assembly	structural constituent of nuclear pore	integral to membrane|nuclear pore|nuclear pore inner ring
YIL032C_d	YIL032C	YIL032C	hom	Dubious	2.54226718622033	0.00550679731515197	no	155	0.00834150829983333	70	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPR052C	YPR052C	NHP6A	hom	Verified	2.52914309358214	0.00571706998343287	no	156	0.0038311980669855	80	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		High-mobility group (HMG) protein, binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to chromosomes; functionally redundant with Nhp6Bp; homologous to mammalian HMGB1 and HMGB2; NHP6A has a paralog, NHP6B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	mismatch repair|DNA replication-independent nucleosome organization|RNA polymerase II transcriptional preinitiation complex assembly|RNA polymerase III transcriptional preinitiation complex assembly|chromatin remodeling	nucleosome binding|sequence-specific DNA binding|DNA binding, bending	MutSalpha complex|nucleus
YDR313C	YDR313C	PIB1	hom	Verified	2.52878116074247	0.00572296846788128	no	157	0.00509205745261497	69	NA					RING-type ubiquitin ligase of the endosomal and vacuolar membranes, binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain	protein ubiquitination	ubiquitin-protein ligase activity|phosphatidylinositol-3-phosphate binding	fungal-type vacuole membrane|late endosome
YGR286C	YGR286C	BIO2	hom	Verified	2.5261519758881	0.005765979150918	no	158	0.00465530212959344	90	NA	FT	KETONE METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Biotin synthase, catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant	biotin biosynthetic process	biotin synthase activity	mitochondrion
YNL326C	YNL326C	PFA3	hom	Verified	2.52534429282556	0.00577924946512627	no	159	0.00684377414556274	71	NA	FT	MEMBRANE ORGANIZATION			Palmitoyltransferase for Vac8p, required for vacuolar membrane fusion; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; autoacylates; required for vacuolar integrity under stress conditions	vacuole fusion, non-autophagic|protein palmitoylation	palmitoyltransferase activity	fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YIL023C	YIL023C	YKE4	hom	Verified	2.51299573663457	0.00598553908026258	no	160	0.00344929786809985	55	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Zinc transporter; localizes to the ER; null mutant is sensitive to calcofluor white, leads to zinc accumulation in cytosol; ortholog of the mouse KE4 and member of the ZIP (ZRT, IRT-like Protein) family	zinc ion transport	zinc ion transmembrane transporter activity	integral to membrane|endoplasmic reticulum
YDR179W-A_p	YDR179W-A	YDR179W-A	hom	Uncharacterized	2.50724796579686	0.00608376599784927	no	161	0.00578211595670614	52	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YDR357C_p	YDR357C	CNL1	hom	Uncharacterized	2.49988165115393	0.0062117400868251	no	162	0.00358949286472112	54	NA					Protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	BLOC-1 complex|cytoplasm
YKL213C	YKL213C	DOA1	hom	Verified	2.48060535567943	0.00655797484794642	no	163	0.00614022087146726	84	NA	FT	RESPONSE TO DNA DAMAGE|PROTEOLYSIS	NUCLEUS		WD repeat protein required for ubiquitin-mediated protein degradation; forms a complex with Cdc48p; plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon DNA replication stress	double-strand break repair via nonhomologous end joining|ubiquitin-dependent protein catabolic process	ubiquitin binding	nucleus|cytoplasm
YBR128C	YBR128C	ATG14	hom	Verified	2.4748448807633	0.00666470277864434	no	164	0.00551746866180828	79	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION			Autophagy-specific subunit of phosphatidylinositol 3-kinase complex I (with Vps34/15/30p); Atg14p targets complex I to the phagophore assembly site (PAS); required for localizing additional ATG proteins to the PAS; required for overflow degradation of misfolded proteins when ERAD is saturated; homolog of human Barkor	piecemeal microautophagy of nucleus|ER-associated protein catabolic process|peroxisome degradation|macroautophagy|CVT pathway	1-phosphatidylinositol-3-kinase activity	phosphatidylinositol 3-kinase complex I|fungal-type vacuole membrane|pre-autophagosomal structure|extrinsic to membrane
YOR306C	YOR306C	MCH5	hom	Verified	2.47249956914841	0.0067085937685909	no	165	0.00314336552861354	53	NA	FT		PLASMA MEMBRANE		Plasma membrane riboflavin transporter; facilitates the uptake of vitamin B2; required for FAD-dependent processes; sequence similarity to mammalian monocarboxylate permeases, however mutants are not deficient in monocarboxylate transport	riboflavin transport	monocarboxylic acid transmembrane transporter activity|riboflavin transporter activity	integral to membrane|plasma membrane
YDR061W_p	YDR061W	YDR061W	hom	Uncharacterized	2.46559778270307	0.00683924173958073	no	166	0.00714560064861114	65	NA	FT	NUCLEOTIDE METABOLISM	MITOCHONDRION		Protein with similarity to ATP-binding cassette (ABC) transporter family members; lacks predicted membrane-spanning regions; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance	biological_process	molecular_function	mitochondrion
YDR391C_p	YDR391C	YDR391C	hom	Uncharacterized	2.46150110364133	0.00691784860339973	no	167	0.00640974366229655	65	NA	FT		NUCLEUS		Putative protein of unknown function, possibly involved in zinc homeostasis; Bdf1p-dependent transcription induced by salt stress; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	biological_process	molecular_function	nucleus|cytoplasm
YGR164W_d	YGR164W	YGR164W	hom	Dubious	2.45780355303641	0.00698948085659164	no	168	0.00673607089672684	114	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR120C	YDR120C	TRM1	hom	Verified	2.45745716249504	0.00699622486774884	no	169	0.00982060870102222	125	NA	FT	RNA PROCESSING	ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION		tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments	tRNA methylation	tRNA (guanine-N2-)-methyltransferase activity	mitochondrion|nuclear envelope|nuclear inner membrane
YDR295C	YDR295C	HDA2	hom	Verified	2.44771129119095	0.00718834015341385	no	170	0.00422405434197922	46	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex containing an Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance	negative regulation of transcription from RNA polymerase II promoter|gene silencing by RNA|histone deacetylation|gene silencing involved in chronological cell aging	histone deacetylase activity|chromatin binding|DNA binding	nucleus|HDA1 complex
YDL169C	YDL169C	UGX2	hom	Verified	2.43767473888236	0.00739103399453817	no	171	0.0065633890365502	63	NA					Protein of unknown function, transcript accumulates in response to any combination of stress conditions	biological_process	molecular_function	cellular_component
YDL167C	YDL167C	NRP1	hom	Verified	2.4364801806774	0.00741549108521332	no	172	0.00978513005498102	111	NA					Putative RNA binding protein of unknown function; localizes to stress granules induced by glucose deprivation; predicted to be involved in ribosome biogenesis	biological_process	molecular_function	cytoplasmic stress granule|cytoplasm
YOR357C	YOR357C	SNX3	hom	Verified	2.43532578343979	0.00743919366007685	no	173	0.00799863261069777	113	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p	protein localization|late endosome to Golgi transport	phosphatidylinositol-3-phosphate binding	cytosol|endosome
YLR251W	YLR251W	SYM1	hom	Verified	2.41571012450364	0.00785227913418395	no	174	0.00537979618532111	65	NA	FT		MITOCHONDRION		Protein required for ethanol metabolism; induced by heat shock and localized to the inner mitochondrial membrane; homologous to mammalian peroxisomal membrane protein Mpv17	ethanol metabolic process	molecular_function	mitochondrion|integral to membrane|mitochondrial inner membrane
YGR170W	YGR170W	PSD2	hom	Verified	2.41381052518338	0.0078933347133766	no	175	0.00783504656133063	81	NA	FT	LIPID METABOLISM	GOLGI APPARATUS		Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes, converts phosphatidylserine to phosphatidylethanolamine	phosphatidylcholine biosynthetic process	phosphatidylserine decarboxylase activity	endosome
YDR372C	YDR372C	VPS74	hom	Verified	2.40312170034805	0.00812788825368586	no	176	0.0157066114068214	153	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING	ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS		Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33	retrograde vesicle-mediated transport, Golgi to ER|endoplasmic reticulum unfolded protein response|protein localization to Golgi apparatus	enzyme binding|phosphatidylinositol-4-phosphate binding	cytosol|Golgi apparatus|nucleus|extrinsic to membrane|cytoplasm
YNL268W	YNL268W	LYP1	hom	Verified	2.39799657157076	0.00824250976880662	no	177	0.00909579317774489	122	NA	FT		MITOCHONDRION|PLASMA MEMBRANE		Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids	basic amino acid transport	basic amino acid transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YER046W	YER046W	SPO73	hom	Verified	2.39751836361365	0.00825327677816442	no	178	0.00609488398788174	69	NA	FT	CELL WALL ORG/BIOGENESIS			Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis	ascospore wall assembly|ascospore formation	molecular_function	cytosol
YPR199C	YPR199C	ARR1	hom	Verified	2.38477925557993	0.0085446861238318	no	179	0.00562447614330288	81	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Transcriptional activator of the basic leucine zipper (bZIP) family, required for transcription of genes involved in resistance to arsenic compounds	positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|cytoplasm
YOR307C	YOR307C	SLY41	hom	Verified	2.37322822337354	0.00881668231299677	no	180	0.00995507781314563	76	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOPLASMIC RETICULUM		Protein involved in ER-to-Golgi transport	ER to Golgi vesicle-mediated transport	molecular_function	integral to membrane|endoplasmic reticulum
YDR259C	YDR259C	YAP6	hom	Verified	2.35916752138504	0.00915799268892938	no	181	0.00484338183067032	64	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Basic leucine zipper (bZIP) transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; overexpression increases sodium and lithium tolerance; computational analysis suggests a role in regulation of expression of genes involved in carbohydrate metabolism; YAP6 has a paralog, CIN5, that arose from the whole genome duplication	negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding transcription factor recruiting transcription factor activity|sequence-specific DNA binding RNA polymerase II transcription factor activity|sequence-specific DNA binding	nucleus
YDR265W	YDR265W	PEX10	hom	Verified	2.3584579591732	0.0091755191354076	no	182	0.00870799272090182	93	NA	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION			Peroxisomal membrane E3 ubiquitin ligase, required for for Ubc4p-dependent Pex5p ubiquitination and peroxisomal matrix protein import; contains zinc-binding RING domain; mutations in human homolog cause various peroxisomal disorders	protein import into peroxisome matrix|protein ubiquitination	ubiquitin-protein ligase activity|protein binding	peroxisomal membrane
YGR141W	YGR141W	VPS62	hom	Verified	2.35536476433739	0.00925226561081061	no	183	0.00626377002509002	59	NA	FT	PROTEIN LOCALIZATION|VACUOLAR TRANSPORT			Vacuolar protein sorting (VPS) protein required for cytoplasm to vacuole targeting of proteins	protein targeting to vacuole	molecular_function	cellular_component
YDR278C_d	YDR278C	YDR278C	hom	Dubious	2.34484351164603	0.0095175334832651	no	184	0.00600676997677182	65	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR007W	YDR007W	TRP1	hom	Verified	2.34327441331185	0.00955765898726097	no	185	0.112323515724882	628	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM			Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA)	tryptophan biosynthetic process	phosphoribosylanthranilate isomerase activity	cytoplasm
YDR217C	YDR217C	RAD9	hom	Verified	2.34145172298842	0.00960445502822879	no	186	0.00824355745523462	73	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		DNA damage-dependent checkpoint protein; required for cell-cycle arrest in G1/S, intra-S, and G2/M; transmits checkpoint signal by activating Rad53p and Chk1p; hyperphosphorylated by Mec1p and Tel1p; multiple cyclin dependent kinase consensus sites and the C-terminal BRCT domain contribute to DNA damage checkpoint activation; potential Cdc28p substrate	DNA repair|mitotic cell cycle G1/S transition DNA damage checkpoint|regulation of cell cycle|intra-S DNA damage checkpoint|nucleotide-excision repair|DNA damage checkpoint|positive regulation of transcription from RNA polymerase II promoter	double-stranded DNA binding|histone binding	chromatin|nucleus
YGL237C	YGL237C	HAP2	hom	Verified	2.30923798623271	0.0104651893712148	no	187	0.0071793471679342	67	NA	FT	TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding	carbon catabolite activation of transcription from RNA polymerase II promoter|regulation of cellular respiration	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	CCAAT-binding factor complex|nucleus
YDR260C	YDR260C	SWM1	hom	Verified	2.29207466433451	0.0109506675462448	no	188	0.0117850953989718	102	NA	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|PROTEOLYSIS	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation	ascospore wall assembly|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|regulation of mitotic metaphase/anaphase transition|protein ubiquitination	molecular_function	anaphase-promoting complex|nucleus
YNL259C	YNL259C	ATX1	hom	Verified	2.28453694348039	0.0111699969904736	no	189	0.0132208534544113	126	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS			Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake	copper ion transport|cellular response to oxidative stress|cellular iron ion homeostasis	copper chaperone activity	cytosol
YDR319C_p	YDR319C	YFT2	hom	Uncharacterized	2.28424280164	0.0111786326927588	no	190	0.0109957218474375	106	NA					Protein required for normal ER membrane biosynthesis; member of the highly conserved FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; interacts with Sst2p and Hsp82p in high-throughput two-hybrid screens	biological_process	molecular_function	integral to membrane
YDR370C	YDR370C	DXO1	hom	Verified	2.28156041629426	0.0112576529771023	no	191	0.00923425920454531	88	NA					Protein with decapping and 5′-3′ exoRNase activity; similar to Rai1p	biological_process	molecular_function	cytoplasm
YER128W	YER128W	VFA1	hom	Verified	2.27730300473661	0.0113840688199903	no	192	0.0114284023020803	117	NA	FT	VACUOLAR TRANSPORT			Protein that interacts with Vps4p and has a role in vacuolar sorting; localizes to endosomes in a Vps4-dependent manner; overexpression causes canavanine sensitivity and confers a partial class D vacuole morphology	vacuolar transport	molecular_function	endosome|cytoplasm
YGR206W	YGR206W	MVB12	hom	Verified	2.26836906935724	0.0116533606775234	no	193	0.0101024883441067	107	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|VACUOLAR TRANSPORT			ESCRT-I subunit required to stabilize oligomers of the ESCRT-I core complex (Stp22p, Vps28p, Srn2p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; deletion mutant is sensitive to rapamycin and nystatin	negative regulation of protein complex assembly|protein targeting to vacuole|endosome transport via multivesicular body sorting pathway	ubiquitin binding	cytosol|endosome|ESCRT I complex
YDL242W_d	YDL242W	YDL242W	hom	Dubious	2.25756625748521	0.011986357157767	no	194	0.0069614434155075	53	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YAL009W	YAL009W	SPO7	hom	Verified	2.25656131773123	0.0120177498784552	no	195	0.021328508025211	216	NA	FF|FT	CELL CYCLE|LIPID METABOLISM|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology, premeiotic replication, and sporulation	negative regulation of phospholipid biosynthetic process|nuclear envelope organization	phosphoprotein phosphatase activity	Nem1-Spo7 phosphatase complex|integral to membrane
YMR245W_d	YMR245W	YMR245W	hom	Dubious	2.24093687458599	0.0125150821305974	no	196	0.0233505321498136	192	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOL114C_p	YOL114C	YOL114C	hom	Uncharacterized	2.23497987854312	0.0127093348831518	no	197	0.0133186787915299	120	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION			Putative protein of unknown function with similarity to human ICT1 and prokaryotic factors that may function in translation termination; YOL114C is not an essential gene	biological_process	molecular_function	cellular_component
YER080W	YER080W	AIM9	hom	Verified	2.2272216820434	0.0129662308675799	no	198	0.0142295237953869	70	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	mitochondrion
YNL080C	YNL080C	EOS1	hom	Verified	2.22369405521667	0.0130845177393226	no	199	0.0186029204310496	105	NA	FT	CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein involved in N-glycosylation; deletion mutation confers sensitivity to exidative stress and shows synthetic lethality with mutations in the spindle checkpoint genes BUB3 and MAD1; YNL080C is not an essential gene	cellular response to oxidative stress|protein N-linked glycosylation	molecular_function	integral to membrane|endoplasmic reticulum membrane
YER186C_p	YER186C	YER186C	hom	Uncharacterized	2.21415783829876	0.0134089615263348	no	200	0.0142753739082565	119	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YML028W	YML028W	TSA1	hom	Verified	2.19417649776686	0.0141113617366847	no	201	0.0107617166133796	121	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|TRANSLATION|OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS			Thioredoxin peroxidase; acts as both a ribosome-associated and free cytoplasmic antioxidant; self-associates to form a high-molecular weight chaperone complex under oxidative stress; deletion results in mutator phenotype; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress	protein folding|cellular response to oxidative stress|replicative cell aging|DNA protection|DNA damage checkpoint|cell redox homeostasis|response to hydroperoxide	unfolded protein binding|ribosome binding|peroxiredoxin activity|thioredoxin peroxidase activity	cytosol|polysome|cytoplasm
YGL066W	YGL066W	SGF73	hom	Verified	2.1941519448824	0.0141122439798995	no	202	0.0243927805515063	144	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|RNA LOCALIZATION	NUCLEUS	HISTONE ACETYLTRANSFERASE	SAGA complex subunit; has a role in anchoring the deubiquitination module into SAGA and SLIK complexes; involved in preinitiation complex assembly at promoters; human ortholog ataxin-7 is associated with spinocerebellar ataxia diseases; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay	histone deubiquitination|mRNA export from nucleus|histone acetylation|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|protein complex assembly|chromatin modification	histone acetyltransferase activity|enzyme activator activity|structural molecule activity	DUBm complex|SLIK (SAGA-like) complex|SAGA complex
YKL065C	YKL065C	YET1	hom	Verified	2.19015190354205	0.0142566110204813	no	203	0.00781281542204675	82	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Endoplasmic reticulum transmembrane protein; may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein	biological_process	molecular_function	ribosome|integral to membrane|endoplasmic reticulum|endoplasmic reticulum membrane
YBR036C	YBR036C	CSG2	hom	Verified	2.18865346208301	0.0143110184429807	no	204	0.0343030478034614	243	NA	FF|FT	LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Endoplasmic reticulum membrane protein, required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations; protein abundance increases in response to DNA replication stress	cellular calcium ion homeostasis|glycosphingolipid biosynthetic process	enzyme regulator activity	integral to endoplasmic reticulum membrane|integral to membrane
YDR233C	YDR233C	RTN1	hom	Verified	2.17437335313824	0.0148385538031994	no	205	0.00853716644677698	87	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS		Reticulon protein; stabilizes membrane curvature; involved in nuclear pore assembly and maintenance of tubular ER morphology; mutant overexpressing RTN1 shows increase in tubular ER; interacts with exocyst subunit Sec6p, Yip3p, and Sbh1p; more abundant than Rtn2p; member of the RTNLA subfamily; mutants have reduced phosphatidylserine transfer between the ER and mitochondria; RTN1 has a paralog, RTN2, that arose from the whole genome duplication	endoplasmic reticulum tubular network organization|endoplasmic reticulum organization|endoplasmic reticulum tubular network maintenance|nuclear pore complex assembly	molecular_function	integral to endoplasmic reticulum membrane|mitochondrion|Golgi apparatus|endoplasmic reticulum|cortical endoplasmic reticulum|endoplasmic reticulum tubular network
YGR107W_d	YGR107W	YGR107W	hom	Dubious	2.17221065560004	0.0149198886631265	no	206	0.0148069883807762	119	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOL129W	YOL129W	VPS68	hom	Verified	2.16428996589566	0.0152210511679032	no	207	0.0197936325040568	182	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	MITOCHONDRION		Vacuolar membrane protein of unknown function involved in vacuolar protein sorting; also detected in the mitochondria	late endosome to vacuole transport via multivesicular body sorting pathway|protein targeting to vacuole	molecular_function	Vps55/Vps68 complex|mitochondrion|fungal-type vacuole membrane|integral to membrane
YDR350C	YDR350C	ATP22	hom	Verified	2.16280215034848	0.0152782000758189	no	208	0.0175605223336207	103	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Specific translational activator for the mitochondrial ATP6 mRNA, encoding a subunit of F1F0 ATP synthase; localized to the mitochondrial inner membrane	proton-transporting ATP synthase complex biogenesis|positive regulation of mitochondrial translation	translation regulator activity	mitochondrial inner membrane
YKR045C_p	YKR045C	YKR045C	hom	Uncharacterized	2.16058185382643	0.015363827199614	no	209	0.0154114464828836	106	NA					Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YKL216W	YKL216W	URA1	hom	Verified	2.15644279344645	0.015524553100132	no	210	0.0130985132992321	128	NA	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM			Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid	'de novo' pyrimidine nucleobase biosynthetic process	dihydroorotate dehydrogenase activity	extrinsic to membrane|cytoplasm
YPR054W	YPR054W	SMK1	hom	Verified	2.15127028016961	0.0157274363134139	no	211	0.0072316315526593	94	NA	FT	SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION	MITOCHONDRION		Middle sporulation-specific mitogen-activated protein kinase (MAPK) required for production of the outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p	ascospore wall assembly|protein phosphorylation|negative regulation of sporulation resulting in formation of a cellular spore	MAP kinase activity	mitochondrion
YPL077C_p	YPL077C	YPL077C	hom	Uncharacterized	2.15083898799611	0.0157444552941088	no	212	0.0169561078725814	132	NA					Putative protein of unknown function; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene; YPL077C has a paralog, YBR197C, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YCR099C_p	YCR099C	YCR099C	hom	Uncharacterized	2.13927721504346	0.0162066119406883	no	213	0.0168088321400634	168	NA					Putative protein of unknown function	biological_process	molecular_function	integral to membrane
YNL013C_d	YNL013C	YNL013C	hom	Dubious	2.13877336430842	0.0162270138190516	no	214	0.00820962323215967	76	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF HEF3/YNL014W	Unknown	Unknown	Unknown
YPR123C_d	YPR123C	YPR123C	hom	Dubious	2.13205310232148	0.0165012406862209	no	215	0.0847526880238632	404	NA	FF				Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CTR	Unknown	Unknown	Unknown
YDR422C	YDR422C	SIP1	hom	Verified	2.12473160551776	0.0168045073243915	no	216	0.0147343981768568	82	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|SIGNALING|PROTEIN PHOSPHORYLATION			Alternate beta-subunit of the Snf1p kinase complex, may confer substrate specificity; vacuolar protein containing KIS (Kinase-Interacting Sequence) and ASC (Association with Snf1 kinase Complex) domains involved in protein interactions	signal transduction|protein phosphorylation|regulation of protein complex assembly	AMP-activated protein kinase activity	AMP-activated protein kinase complex|fungal-type vacuole
YPL111W	YPL111W	CAR1	hom	Verified	2.12459598711258	0.01681016950137	no	217	0.0201145706464544	144	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS|SITE OF POLARIZED GROWTH		Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance	regulation of ornithine metabolic process|arginine catabolic process to ornithine	manganese ion binding|arginase activity|ornithine carbamoyltransferase inhibitor activity|zinc ion binding	cytosol|nucleus|mating projection tip|cytoplasm
YKL006W	YKL006W	RPL14A	hom	Verified	2.12373596626484	0.0168461140579856	no	218	0.0257458785355899	190	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L14A; N-terminally acetylated; homologous to mammalian ribosomal protein L14, no bacterial homolog; RPL14A has a paralog, RPL14B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YPL234C	YPL234C	VMA11	hom	Verified	2.11879197224296	0.0170540257449219	no	219	0.0199334689386903	124	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Vacuolar ATPase V0 domain subunit c', involved in proton transport activity; hydrophobic integral membrane protein (proteolipid) containing four transmembrane segments; N and C termini are in the vacuolar lumen	vacuolar acidification	proton-transporting ATPase activity, rotational mechanism	vacuolar proton-transporting V-type ATPase, V0 domain|integral to membrane|fungal-type vacuole
YPL165C	YPL165C	SET6	hom	Verified	2.11767137572954	0.0171014543420003	no	220	0.0105521255852982	83	NA					SET domain protein of unknown function; deletion heterozygote is sensitive to compounds that target ergosterol biosynthesis, may be involved in compound availability	biological_process	molecular_function	cellular_component
YDR210W_p	YDR210W	YDR210W	hom	Uncharacterized	2.11629743293649	0.0171597594726127	no	221	0.00586886919025765	36	NA	FT		PLASMA MEMBRANE		Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery	biological_process	molecular_function	cellular_component
YDR157W_d	YDR157W	YDR157W	hom	Dubious	2.11325391475003	0.0172895204542077	no	222	0.0156952443216529	105	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKL175W	YKL175W	ZRT3	hom	Verified	2.10260104620957	0.0177503292044354	no	223	0.0125909223560394	83	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Vacuolar membrane zinc transporter, transports zinc from storage in the vacuole to the cytoplasm when needed; transcription is induced under conditions of zinc deficiency	cellular zinc ion homeostasis|zinc ion transport	zinc ion transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane
YDL088C	YDL088C	ASM4	hom	Verified	2.10232849445593	0.0177622550857619	no	224	0.0169888215657396	132	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	FG-nucleoporin component of central core of nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport; induces membrane tubulation, which may contribute to nuclear pore assembly; ASM4 has a paralog, NUP53, that arose from the whole genome duplication	nuclear pore organization|mRNA export from nucleus in response to heat stress|mitotic cell cycle spindle assembly checkpoint	nucleocytoplasmic transporter activity|phospholipid binding|single-stranded DNA binding	nuclear pore central transport channel|integral to membrane|nuclear pore
YKL106W	YKL106W	AAT1	hom	Verified	2.10228282527449	0.0177642540729116	no	225	0.0119321691269917	121	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis	aspartate catabolic process|chronological cell aging|replicative cell aging|asparagine biosynthetic process from oxaloacetate|aspartate biosynthetic process	L-aspartate:2-oxoglutarate aminotransferase activity	mitochondrion
YOR038C	YOR038C	HIR2	hom	Verified	2.09303790255886	0.0181728856082577	no	226	0.0150012229278897	128	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS		Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p	DNA replication-independent nucleosome assembly|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter	nucleosome binding|transcription corepressor activity|DNA binding	HIR complex|nucleus
YOL162W_p	YOL162W	YOL162W	hom	Uncharacterized	2.08008998869715	0.0187586398426522	no	227	0.0108956356240498	91	NA					Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family	transmembrane transport	transmembrane transporter activity	integral to membrane|membrane
YOR026W	YOR026W	BUB3	hom	Verified	2.07069649161587	0.0191935841546197	no	228	0.0184082702309672	146	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME	KINETOCHORE	Kinetochore checkpoint WD40 repeat protein that localizes to kinetochores during prophase and metaphase, delays anaphase in the presence of unattached kinetochores; forms complexes with Mad1p-Bub1p and with Cdc20p, binds Mad2p and Mad3p	mitotic cell cycle G2/M transition decatenation checkpoint|mitotic cell cycle spindle assembly checkpoint	ubiquitin binding	mitotic checkpoint complex|condensed nuclear chromosome kinetochore
YPL096W	YPL096W	PNG1	hom	Verified	2.06792403926476	0.0193235832593094	no	229	0.0224741773253729	121	NA	FT	RESPONSE TO DNA DAMAGE|PROTEOLYSIS	NUCLEUS|MITOCHONDRION		Conserved peptide N-glycanase required for deglycosylation of misfolded glycoproteins during proteasome-dependent degradation; localizes to the cytoplasm and nucleus; activity is enhanced by interaction with Rad23p	misfolded or incompletely synthesized protein catabolic process|protein deglycosylation	peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity	cytosol|mitochondrion|nucleus
YGR275W	YGR275W	RTT102	hom	Verified	2.06737387568295	0.0193494689687637	no	230	0.025647883531102	121	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|CHROMOSOME SEGREGATION	NUCLEUS	RSC COMPLEX	Component of both the SWI/SNF and RSC chromatin remodeling complexes; suggested role in chromosome maintenance; possible weak regulator of Ty1 transposition; protein abundance increases in response to DNA replication stress	chromosome segregation|nucleosome disassembly|chromatin remodeling|transcription elongation from RNA polymerase II promoter	molecular_function	RSC complex|SWI/SNF complex|nucleus
YER044C	YER044C	ERG28	hom	Verified	2.06581433499791	0.0194230070088382	no	231	0.0235442150305177	138	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Endoplasmic reticulum membrane protein, may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER, also interacts with Erg6p	ergosterol biosynthetic process	protein binding, bridging	endoplasmic reticulum membrane
YER187W_p	YER187W	YER187W	hom	Uncharacterized	2.05922041208578	0.0197365643145625	no	232	0.012548471783933	101	NA					Putative protein of unknown function; induced in respiratory-deficient cells	biological_process	molecular_function	cellular_component
YDR287W	YDR287W	INM2	hom	Verified	2.05834155447464	0.0197786789323982	no	233	0.0183026641739585	112	NA	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM			Inositol monophosphatase, involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy	inositol phosphate dephosphorylation	inositol monophosphate 1-phosphatase activity	cellular_component
YOR255W	YOR255W	OSW1	hom	Verified	2.05368940459474	0.0200028813474492	no	234	0.0180917615974413	141	NA	FT	CELL WALL ORG/BIOGENESIS			Protein involved in sporulation; required for the construction of the outer spore wall layers; required for proper localization of Spo14p	ascospore wall assembly|ascospore formation	molecular_function	prospore membrane
YML034W	YML034W	SRC1	hom	Verified	2.04640055916282	0.020358488557075	no	235	0.034294705872273	246	NA	FF|FT	CELL CYCLE|CHROMOSOME SEGREGATION	ENDOMEMBRANE SYSTEM|NUCLEUS		Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance	maintenance of rDNA|mitotic sister chromatid segregation	molecular_function	nuclear envelope
YDR213W	YDR213W	UPC2	hom	Verified	2.03680654545107	0.0208347160641449	no	236	0.0233219574554792	187	NA	FT	TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM	NUCLEUS		Sterol regulatory element binding protein; induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; relocates from intracellular membranes to perinuclear foci on sterol depletion; UPC2 has a paralog, ECM22, that arose from the whole genome duplication	cellular response to hypoxia|positive regulation of ergosterol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|membrane|cytoplasm|perinuclear region of cytoplasm
YGR268C	YGR268C	HUA1	hom	Verified	2.03492090353039	0.0209294161553923	no	237	0.0287138360184162	188	NA					Cytoplasmic protein containing a zinc finger domain with sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly	biological_process	molecular_function	cytoplasm
YER015W	YER015W	FAA2	hom	Verified	2.03314517158462	0.021018929226523	no	238	0.0212345243790825	166	NA	FT	KETONE METABOLISM|LIPID METABOLISM	MITOCHONDRION		Medium chain fatty acyl-CoA synthetase, activates imported fatty acids; accepts a wide range of fatty acid chain lengths with a preference for medium chains, C9:0-C13:0; localized to the peroxisome	long-chain fatty acid metabolic process	long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity|medium-chain fatty acid-CoA ligase activity	mitochondrion|peroxisome
YDR256C	YDR256C	CTA1	hom	Verified	2.03267935052164	0.0210424644210419	no	239	0.0189691359307138	141	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		Catalase A, breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation	response to reactive oxygen species|age-dependent response to reactive oxygen species|hydrogen peroxide catabolic process	catalase activity	peroxisomal matrix|mitochondrial matrix
YDL026W_d	YDL026W	YDL026W	hom	Dubious	2.03061200974637	0.02114718423549	no	240	0.0256388122763057	156	NA					Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YBR058C	YBR058C	UBP14	hom	Verified	2.0276542768242	0.0212977726367757	no	241	0.0239808722874115	158	NA	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS	NUCLEUS		Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase T	protein deubiquitination|negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process	ubiquitin-specific protease activity	cytoplasm
YOL100W	YOL100W	PKH2	hom	Verified	2.02702251372757	0.021330055143977	no	242	0.0239594407540803	178	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION	NUCLEUS		Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh1p	regulation of nuclear-transcribed mRNA poly(A) tail shortening|protein phosphorylation|MAPK cascade involved in cell wall biogenesis|cytoplasmic mRNA processing body assembly	protein kinase activity	cell cortex|eisosome|nucleus
YGR127W_p	YGR127W	YGR127W	hom	Uncharacterized	2.02273352290797	0.0215503143567165	no	243	0.0131529737007012	103	NA					Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response	biological_process	molecular_function	cellular_component
YKL218C	YKL218C	SRY1	hom	Verified	2.01954340649336	0.0217153852630456	no	244	0.0155210061428176	120	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required in the presence of hydroxyaspartate; highly similar to mouse serine racemase (Srr) but has no serine racemase activity	cellular modified amino acid catabolic process	serine racemase activity|threo-3-hydroxyaspartate ammonia-lyase activity	cellular_component
YKL068W	YKL068W	NUP100	hom	Verified	2.01512720105457	0.021945661404932	no	245	0.0175050992235149	135	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; homologous to Nup116p	positive regulation of transcription, DNA-dependent|mRNA export from nucleus|NLS-bearing substrate import into nucleus|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|protein import into nucleus|protein targeting to nuclear inner membrane|mRNA export from nucleus in response to heat stress	nucleocytoplasmic transporter activity|structural constituent of nuclear pore	nuclear pore central transport channel|integral to membrane|nuclear pore
YKL061W_p	YKL061W	BLI1	hom	Uncharacterized	2.01458100495574	0.0219742847041245	no	246	0.0159587554562367	104	NA					Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome	biological_process	molecular_function	endosome
YKL119C	YKL119C	VPH2	hom	Verified	2.00623065263786	0.0224158224524322	no	247	0.0239471186787841	148	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Integral membrane protein required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER)	vacuolar proton-transporting V-type ATPase complex assembly|vacuolar acidification	molecular_function	endoplasmic reticulum membrane
YOR061W	YOR061W	CKA2	hom	Verified	2.00321195290147	0.0225772716180188	no	248	0.0333833087412766	253	NA	FF|FT	RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION	NUCLEUS		Alpha' catalytic subunit of casein kinase 2 (CK2); CK2 is a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; protein abundance increases in response to DNA replication stress; regulates Fkh1p-mediated donor preference during mating-type switching	regulation of transcription from RNA polymerase I promoter|chronological cell aging|protein phosphorylation|regulation of transcription from RNA polymerase III promoter|response to DNA damage stimulus	protein serine/threonine kinase activity	protein kinase CK2 complex|UTP-C complex
YOL029C_p	YOL029C	YOL029C	hom	Uncharacterized	2.0016649633642	0.022660388510896	no	249	0.0203205255572335	145	NA					Putative protein of unknown function; identified as interacting with Hsc82p and Hsp82p in high-throughput two-hybrid screens	biological_process	molecular_function	cellular_component
YJL214W	YJL214W	HXT8	hom	Verified	1.99742580255557	0.022889473587617	no	250	0.0226241633031522	143	NA	FT		PLASMA MEMBRANE		Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose	hexose transport	mannose transmembrane transporter activity|glucose transmembrane transporter activity|fructose transmembrane transporter activity	integral to membrane|plasma membrane
YDR229W	YDR229W	IVY1	hom	Verified	1.99635307186442	0.0229477525176536	no	251	0.0262663654471171	149	NA	FT	MEMBRANE ORGANIZATION			Phospholipid-binding protein that interacts with both Ypt7p and Vps33p, may partially counteract the action of Vps33p and vice versa, localizes to the rim of the vacuole as cells approach stationary phase	vacuole fusion, non-autophagic	phospholipid binding	fungal-type vacuole membrane
YJR130C	YJR130C	STR2	hom	Verified	1.99610329948345	0.0229613399872783	no	252	0.0187694269438784	116	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Cystathionine gamma-synthase, converts cysteine into cystathionine	sulfur compound metabolic process|transsulfuration	cystathionine gamma-synthase activity	nucleus|cytoplasm
YKL020C	YKL020C	SPT23	hom	Verified	1.99364231817141	0.0230955786007176	no	253	0.0163407448209741	150	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|GENE SILENCING	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Mga2p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting	cellular response to cold|positive regulation of unsaturated fatty acid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette	DNA binding	integral to endoplasmic reticulum membrane|nucleus
YKL211C	YKL211C	TRP3	hom	Verified	1.99218831226251	0.0231752000662299	no	254	0.225391038323591	860	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM			Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p	tryptophan biosynthetic process	indole-3-glycerol-phosphate synthase activity|anthranilate synthase activity	anthranilate synthase complex|cytoplasm
YOL163W_p	YOL163W	YOL163W	hom	Uncharacterized	1.9910355799153	0.0232384878876793	no	255	0.0176003965793749	91	NA					Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family	transmembrane transport	transmembrane transporter activity	integral to membrane|membrane
YIL057C	YIL057C	RGI2	hom	Verified	1.98953899944452	0.0233208708043875	no	256	0.0301833421835711	165	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY			Protein of unknown function involved in energy metabolism under respiratory conditions; expression induced under carbon limitation and repressed under high glucose	energy reserve metabolic process	molecular_function	cytoplasm
YMR317W_p	YMR317W	YMR317W	hom	Uncharacterized	1.98072395863872	0.0238111192122264	no	257	0.0197399223306717	149	NA					Putative protein of unknown function with some similarity to sialidase from Trypanosoma; YMR317W is not an essential gene	biological_process	molecular_function	cellular_component
YLR412W	YLR412W	BER1	hom	Verified	1.98042042898097	0.0238281531500304	no	258	0.0206776744750928	142	NA	FT		CYTOSKELETON		Protein involved in microtubule-related processes, N-acetylation; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene; similar to Arabidopsis SRR1 gene	biological_process	molecular_function	cytoplasm
YKL183W	YKL183W	LOT5	hom	Verified	1.97914399765031	0.0238998980161062	no	259	0.0167248844473555	129	NA	FT		NUCLEUS		Protein of unknown function; gene expression increases in cultures shifted to a lower temperature; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YDR536W	YDR536W	STL1	hom	Verified	1.9641905307532	0.0247540002681528	no	260	0.0285139199620439	182	NA	FT		PLASMA MEMBRANE		Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock	transport|glycerol transport|transmembrane transport	solute:hydrogen symporter activity|transporter activity	integral to membrane|plasma membrane|membrane
YDR221W	YDR221W	GTB1	hom	Verified	1.96007411634527	0.02499356403361	no	261	0.0203460612895713	135	NA	FT	CARBOHYDRATE METABOLISM	ENDOPLASMIC RETICULUM		Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p; involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER; relocalizes from ER to cytoplasm upon DNA replication stress	polysaccharide biosynthetic process|protein N-linked glycosylation	alpha-glucosidase activity	glucosidase II complex|endoplasmic reticulum|endoplasmic reticulum lumen
YKL086W	YKL086W	SRX1	hom	Verified	1.95457118045677	0.0253168528495585	no	262	0.0207796266490354	132	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Sulfiredoxin; contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxin Tsa1p, which is formed upon exposure to oxidants; conserved in higher eukaryotes; protein abundance increases in response to DNA replication stress	cellular response to oxidative stress	sulfiredoxin activity	nucleus|cytoplasm
YLR110C	YLR110C	CCW12	hom	Verified	1.95447852481085	0.0253223260725599	no	263	0.0669123643071527	384	NA	FF|FT	CELL WALL ORG/BIOGENESIS	SITE OF POLARIZED GROWTH		Cell wall mannoprotein; plays a role in maintenance of newly synthesized areas of cell wall; localizes to periphery of small buds, septum region of larger buds, and shmoo tip; CCW12 has a paralog, YDR134C, that arose from the whole genome duplication	conjugation with cellular fusion|agglutination involved in conjugation with cellular fusion|fungal-type cell wall organization	molecular_function	fungal-type cell wall|mating projection tip|cellular bud tip
YBR283C	YBR283C	SSH1	hom	Verified	1.953577003993	0.0253756311956751	no	264	0.026453649407806	135	NA	FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Subunit of the Ssh1 translocon complex; Sec61p homolog involved in co-translational pathway of protein translocation; not essential	SRP-dependent cotranslational protein targeting to membrane	protein transmembrane transporter activity|signal sequence binding	integral to membrane|Ssh1 translocon complex
YDR329C	YDR329C	PEX3	hom	Verified	1.95266401385845	0.0254297102409894	no	265	0.0277002661636148	155	NA	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION	ENDOPLASMIC RETICULUM		Peroxisomal membrane protein (PMP) required for proper localization and stability of PMPs; anchors peroxisome retention factor Inp1p at the peroxisomal membrane; interacts with Pex19p	protein import into peroxisome membrane|peroxisome inheritance|ER-dependent peroxisome organization	protein binding	peroxisomal membrane|endoplasmic reticulum
YML014W	YML014W	TRM9	hom	Verified	1.95243345425171	0.0254433822091929	no	266	0.019372101946601	188	NA	FT	RNA PROCESSING	NUCLEUS		tRNA methyltransferase; catalyzes modification of wobble bases in tRNA anticodons to 2, 5-methoxycarbonylmethyluridine and 5-methoxycarbonylmethyl-2-thiouridine; may act as part of a complex with Trm112p; deletion mutation increases translational infidelity, including amino acid misincorporation and -1 frameshifting, and also confers resistance to zymocin; null mutant displays activation of stress responses	chronological cell aging|tRNA methylation|tRNA wobble uridine modification|response to stress	tRNA (uracil) methyltransferase activity	nucleus|cytoplasm
YOL088C	YOL088C	MPD2	hom	Verified	1.94959790094912	0.0256120318927981	no	267	0.0554884449803722	288	NA	FT		ENDOPLASMIC RETICULUM		Member of the protein disulfide isomerase (PDI) family, exhibits chaperone activity; overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions; undergoes oxidation by Ero1p	protein folding	protein disulfide isomerase activity|protein disulfide oxidoreductase activity	endoplasmic reticulum
YBR063C_p	YBR063C	YBR063C	hom	Uncharacterized	1.94796314362592	0.0257096866782654	no	268	0.01873580542037	139	NA					Putative protein of unknown function; YBR063C is not an essential gene	biological_process	molecular_function	cellular_component
YLR396C	YLR396C	VPS33	hom	Verified	1.94670055328566	0.0257853226285849	no	269	0.0335786391622174	157	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT			ATP-binding protein that is a subunit of the HOPS complex and of the CORVET tethering complex; essential for protein sorting, vesicle docking and fusion at the vacuole	regulation of SNARE complex assembly|endocytosis|regulation of vacuole fusion, non-autophagic|piecemeal microautophagy of nucleus|vesicle fusion with vacuole|Golgi to vacuole transport|vacuole organization|vacuole fusion, non-autophagic|vesicle docking|protein targeting to vacuole	phosphatidylinositol binding|ATP binding	cytosol|fungal-type vacuole membrane|HOPS complex|fungal-type vacuole|CORVET complex
YML012C-A_d	YML012C-A	YML012C-A	hom	Dubious	1.94431839005144	0.0259285341701653	no	270	0.033782507961493	252	NA	FF				Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SEL1	Unknown	Unknown	Unknown
YKR031C	YKR031C	SPO14	hom	Verified	1.93688371851452	0.0263797795590257	no	271	0.0234568292271146	164	NA	FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|LIPID METABOLISM	NUCLEUS		Phospholipase D; catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions	phospholipid metabolic process|exocytosis|cell morphogenesis involved in conjugation with cellular fusion|ascospore-type prospore assembly	phospholipase D activity|phosphatidylinositol-3-phosphate binding	endosome|nucleus|prospore membrane
YOL013W-B_d	YOL013W-B	YOL013W-B	hom	Dubious	1.93585795651717	0.0264425501460688	no	272	0.0138172920058442	129	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the long terminal repeat (LTR) of a Ty1 element	Unknown	Unknown	Unknown
YDR075W	YDR075W	PPH3	hom	Verified	1.93568518228854	0.0264531351829736	no	273	0.0164507508746144	159	NA	FT	CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Catalytic subunit of protein phosphatase PP4 complex; active complex is composed of Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; involved in activation of Gln3p to alleviate nitrogen catabolite repression; Pph3p and Psy2p localize to foci on meiotic chromosomes	Unknown|signal transduction involved in meiotic recombination checkpoint|double-strand break repair via homologous recombination|protein dephosphorylation|positive regulation of nitrogen compound metabolic process	protein serine/threonine phosphatase activity	condensed nuclear chromosome|nucleus|cytoplasm
YDR321W	YDR321W	ASP1	hom	Verified	1.93476093497242	0.0265098194738299	no	274	0.0259533487857747	141	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Cytosolic L-asparaginase, involved in asparagine catabolism; catalyzes hydrolysis of L-asparagine to aspartic acid and ammonia, has an important role in therapy of acute lymphoblastic leukemia; synthesized constitutively	asparagine catabolic process	asparaginase activity	intracellular
YOR314W_d	YOR314W	YOR314W	hom	Dubious	1.92978801624711	0.0268165544713205	no	275	0.0253243219461322	139	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGL184C	YGL184C	STR3	hom	Verified	1.92013136804853	0.0274206539958764	no	276	0.028566125186769	163	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Peroxisomal cystathionine beta-lyase, converts cystathionine into homocysteine; may be redox regulated by Gto1p	methionine biosynthetic process|transsulfuration	cystathionine beta-lyase activity	peroxisome
YNL193W_p	YNL193W	YNL193W	hom	Uncharacterized	1.91970913627857	0.0274473247864513	no	277	0.0209679391499148	162	NA					Putative protein of unknown function; exhibits a two-hybrid interaction with Yhr151cp in a large-scale analysis	biological_process	molecular_function	cellular_component
YPL115C	YPL115C	BEM3	hom	Verified	1.91931335928428	0.0274723441652371	no	278	0.0445761764250602	230	NA	FT	SIGNALING	SITE OF POLARIZED GROWTH		Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly	negative regulation of Rho protein signal transduction|establishment of cell polarity	Rho GTPase activator activity|phosphatidylinositol-3-phosphate binding	cell cortex|incipient cellular bud site|mating projection tip|cytoplasm|cellular bud tip
YDR275W	YDR275W	BSC2	hom	Verified	1.91636515606995	0.0276593163593927	no	279	0.026045548634971	149	NA					Protein of unknown function; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; BSC2 has a paralog, IRC23, that arose from the whole genome duplication	biological_process	molecular_function	lipid particle
YOR270C	YOR270C	VPH1	hom	Verified	1.91075995064715	0.0280177183062566	no	280	0.0346441131765376	169	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS			Subunit a of vacuolar-ATPase V0 domain; one of two isoforms (Vph1p and Stv1p); Vph1p is located in V-ATPase complexes of the vacuole while Stv1p is located in V-ATPase complexes of the Golgi and endosomes; relative distribution to the vacuolar membrane decreases upon DNA replication stress	polyphosphate metabolic process|proton transport|protein complex assembly|vacuolar acidification	proton-transporting ATPase activity, rotational mechanism	vacuolar proton-transporting V-type ATPase, V0 domain|fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YKL118W_d	YKL118W	YKL118W	hom	Dubious	1.90821740338794	0.0281815615911692	no	281	0.0782085958574631	379	NA	FF				Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene VPH2	Unknown	Unknown	Unknown
YDR346C	YDR346C	SVF1	hom	Verified	1.90781506680364	0.0282075613567171	no	282	0.0421923974864079	183	NA	FT	RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis; mutant has increased aneuploidy tolerance	cellular response to oxidative stress	molecular_function	nucleus|cytoplasm
YBL099W	YBL099W	ATP1	hom	Verified	1.90509599707156	0.0283837968307197	no	283	0.0357945079910599	182	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	MITOCHONDRION		Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated	ATP synthesis coupled proton transport	hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism	mitochondrial nucleoid|proton-transporting ATP synthase complex, catalytic core F(1)|mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase, catalytic core
YEL013W	YEL013W	VAC8	hom	Verified	1.90374321295147	0.0284718177680231	no	284	0.0216297998724928	184	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Phosphorylated and palmitoylated vacuolar membrane protein that interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions	piecemeal microautophagy of nucleus|vacuole inheritance|CVT vesicle assembly|vacuole fusion, non-autophagic|macroautophagy|nucleus-vacuole junction assembly	protein anchor	fungal-type vacuole membrane|nucleus-vacuole junction|Myo2p-Vac17p-Vac8p transport complex
YPL039W_p	YPL039W	YPL039W	hom	Uncharacterized	1.89920719753503	0.0287686193897114	no	285	0.037761223713673	222	NA					Putative protein of unknown function; YPL039W is not an essential gene	biological_process	molecular_function	cellular_component
YDL025C	YDL025C	RTK1	hom	Verified	1.89528892225871	0.0290270674857519	no	286	0.0535857591943072	213	NA	FT	PROTEIN PHOSPHORYLATION			Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance increases in response to DNA replication stress	biological_process	protein serine/threonine kinase activity|protein kinase activity	cellular_component
YDR273W	YDR273W	DON1	hom	Verified	1.89388034458719	0.0291204469960095	no	287	0.0146547426826709	126	NA	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION			Meiosis-specific component of the spindle pole body, part of the leading edge protein (LEP) coat, forms a ring-like structure at the leading edge of the prospore membrane during meiosis II	meiosis|ascospore wall assembly	molecular_function	prospore membrane
YIL030C	YIL030C	SSM4	hom	Verified	1.88636427439085	0.0296229416744658	no	288	0.0315482914693113	178	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	UBIQUITIN LIGASE COMPLEX	Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation	ER-associated protein catabolic process	ubiquitin-protein ligase activity	nuclear envelope|integral to endoplasmic reticulum membrane|Doa10p ubiquitin ligase complex|integral to membrane|nuclear inner membrane
YJL159W	YJL159W	HSP150	hom	Verified	1.88605535050845	0.0296437481166665	no	289	0.0220118514618544	138	NA	FT	CELL WALL ORG/BIOGENESIS			O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication	fungal-type cell wall organization	structural constituent of cell wall|ATPase activity	fungal-type cell wall|extracellular region
YML017W	YML017W	PSP2	hom	Verified	1.8803973224892	0.0300269741001333	no	290	0.0428242978526392	244	NA					Asn rich cytoplasmic protein that contains RGG motifs; high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha); possible role in mitochondrial mRNA splicing	biological_process	molecular_function	cytoplasm
YOR134W	YOR134W	BAG7	hom	Verified	1.87920415496711	0.0301083112647557	no	291	0.0363632726994549	219	NA	FT	SIGNALING			Rho GTPase activating protein (RhoGAP), stimulates the intrinsic GTPase activity of Rho1p, which plays a role in actin cytoskeleton organization and control of cell wall synthesis; structurally and functionally related to Sac7p	small GTPase mediated signal transduction	Rho GTPase activator activity	intracellular
YMR230W-A_p	YMR230W-A	YMR230W-A	hom	Uncharacterized	1.87856599831668	0.030151888754681	no	292	0.02962941958616	166	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YGR131W	YGR131W	FHN1	hom	Verified	1.87779893476698	0.0302043380286697	no	293	0.0340173976631392	159	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION	PLASMA MEMBRANE		Protein of unknown function; induced by ketoconazole; promoter region contains sterol regulatory element motif, which has been identified as a Upc2p-binding site; overexpression complements function of Nce102p in NCE102 deletion strain	establishment of protein localization to plasma membrane	molecular_function	integral to membrane|membrane raft
YOR171C	YOR171C	LCB4	hom	Verified	1.87342194548049	0.0305050709615375	no	294	0.0209344835569345	147	NA	FT	LIPID METABOLISM|SIGNALING|PROTEIN PHOSPHORYLATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS|PLASMA MEMBRANE		Sphingoid long-chain base kinase, responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomes	calcium-mediated signaling|sphingolipid metabolic process	D-erythro-sphingosine kinase activity	Golgi apparatus|endoplasmic reticulum|plasma membrane|cortical endoplasmic reticulum
YDR274C_d	YDR274C	YDR274C	hom	Dubious	1.87122466825237	0.0306569734721303	no	295	0.0184851279855181	116	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPR031W	YPR031W	NTO1	hom	Verified	1.8673095621536	0.0309291854231067	no	296	0.0432531407829428	206	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS	HISTONE ACETYLTRANSFERASE	Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3	histone acetylation	histone acetyltransferase activity|methylated histone residue binding	nucleus|NuA3 histone acetyltransferase complex|cytoplasm
YLR065C	YLR065C	ENV10	hom	Verified	1.86707399037294	0.0309456280074535	no	297	0.0587223360326999	339	NA	FF|FT	VACUOLAR PROTEIN PROCESSING			Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing; YLR065C is not an essential gene	vacuolar protein processing	molecular_function	integral to membrane
YDL238C	YDL238C	GUD1	hom	Verified	1.85530725484563	0.0317761814038036	no	298	0.0330795394350788	190	NA					Guanine deaminase, a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine; activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures	guanine metabolic process	guanine deaminase activity|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	cytoplasm
YDR035W	YDR035W	ARO3	hom	Verified	1.85409643140016	0.0318626825870483	no	299	0.101742615568505	496	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS|MITOCHONDRION		3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan	aromatic amino acid family biosynthetic process	3-deoxy-7-phosphoheptulonate synthase activity	mitochondrion|nucleus|cytoplasm
YPL095C	YPL095C	EEB1	hom	Verified	1.84603773889412	0.0324433629844957	no	300	0.0421022248981789	215	NA	FT	KETONE METABOLISM|LIPID METABOLISM			Acyl-coenzymeA:ethanol O-acyltransferase; responsible for the major part of medium-chain fatty acid ethyl ester biosynthesis during fermentation; possesses short-chain esterase activity; may be involved in lipid metabolism and detoxification; EEB1 has a paralog, EHT1, that arose from the whole genome duplication	medium-chain fatty acid catabolic process|medium-chain fatty acid biosynthetic process	short-chain carboxylesterase activity|alcohol O-octanoyltransferase activity	cellular_component
YDR386W	YDR386W	MUS81	hom	Verified	1.84496866432664	0.0325210485300221	no	301	0.0528621893653297	265	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS		Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p	DNA repair|DNA topological change|reciprocal meiotic recombination|resolution of meiotic recombination intermediates|response to DNA damage stimulus	crossover junction endodeoxyribonuclease activity|endonuclease activity	Holliday junction resolvase complex|nucleus
YOR333C_d	YOR333C	YOR333C	hom	Dubious	1.84132349861947	0.0327870830727005	no	302	0.0224252840535786	122	NA					Dubious open reading frame, unlikely to encode a functional protein; overlaps 5' end of MRS2 gene required for respiratory growth	Unknown	Unknown	Unknown
YLR325C	YLR325C	RPL38	hom	Verified	1.83397018530626	0.0333292099936989	no	303	0.0476084016582688	201	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L38; homologous to mammalian ribosomal protein L38, no bacterial homolog	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YCR077C	YCR077C	PAT1	hom	Verified	1.83348353029149	0.0333653478106895	no	304	0.0431700447713461	291	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|TRANSLATION|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS	RIBOSOME	Deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; associated with topoisomerase II; functionally linked to Pab1p; forms cytoplasmic foci upon DNA replication stress	deadenylation-dependent decapping of nuclear-transcribed mRNA|chromosome segregation|regulation of translational initiation|formation of translation preinitiation complex|negative regulation of translational initiation|cytoplasmic mRNA processing body assembly	molecular_function	cytosolic small ribosomal subunit|cytoplasmic mRNA processing body
YDR424C	YDR424C	DYN2	hom	Verified	1.83051461798525	0.0335865114697533	no	305	0.0339188526572691	208	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON		Cytoplasmic light chain dynein, microtubule motor protein; proposed to be involved in the assembly of the nuclear pore complex	microtubule-based process|actin filament-based process|nuclear pore complex assembly	molecular_function	cytoplasmic dynein complex|cytoplasmic microtubule|peroxisome|nuclear pore
YPL155C	YPL155C	KIP2	hom	Verified	1.82685795338522	0.0338605647953641	no	306	0.0179831525892364	135	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION	MITOCHONDRION|CYTOSKELETON		Kinesin-related motor protein involved in mitotic spindle positioning, stabilizes microtubules by targeting Bik1p to the plus end; Kip2p levels are controlled during the cell cycle	nuclear migration along microtubule|mitotic anaphase B|negative regulation of microtubule depolymerization	microtubule motor activity	mitochondrion|kinesin complex|cytoplasmic microtubule
YDR279W	YDR279W	RNH202	hom	Verified	1.82563422237008	0.0339526886489033	no	307	0.0241481998787466	128	NA	FT		NUCLEUS		Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS2 that causes Aicardi-Goutieres syndrome	RNA catabolic process|DNA replication, removal of RNA primer	ribonuclease H activity	ribonuclease H2 complex|nucleus
YKL025C	YKL025C	PAN3	hom	Verified	1.82483681627824	0.0340128291345386	no	308	0.0495932163505811	241	NA	FT	RNA PROCESSING|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION			Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes	DNA repair|mRNA 3'-end processing|postreplication repair	poly(A)-specific ribonuclease activity	PAN complex|cytoplasm
YKR033C_d	YKR033C	YKR033C	hom	Dubious	1.82425132258777	0.0340570429088297	no	309	0.0343900662681329	156	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene DAL80	Unknown	Unknown	Unknown
YDR244W	YDR244W	PEX5	hom	Verified	1.82055667654302	0.0343371367387628	no	310	0.0487618247168561	169	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PEROXISOME ORGANIZATION			Peroxisomal membrane signal receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions	protein import into peroxisome matrix, docking	peroxisome matrix targeting signal-1 binding|protein binding, bridging	cytosol|peroxisomal membrane|peroxisome
YGL258W	YGL258W	VEL1	hom	Verified	1.81829441709867	0.0345095728237885	no	311	0.054441229455398	239	NA					Protein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants; VEL1 has paralog YOR387C	biological_process	molecular_function	cytosol
YKL027W	YKL027W	YKL027W	hom	Verified	1.81346372170277	0.0348801645595027	no	312	0.03676804818116	189	NA	FT		MITOCHONDRION		Protein of unknown function, localized to the mitochondrial outer membrane	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion
YHR199C	YHR199C	AIM46	hom	Verified	1.8118095755764	0.0350078125161788	no	313	0.0649662227695853	267	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	mitochondrion
YKR069W	YKR069W	MET1	hom	Verified	1.81030257985344	0.035124438603778	no	314	0.0352870543221859	156	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM			S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis	siroheme biosynthetic process|methionine biosynthetic process|sulfate assimilation	uroporphyrin-III C-methyltransferase activity	intracellular
YDR056C_p	YDR056C	YDR056C	hom	Uncharacterized	1.80980208806642	0.0351632420069644	no	315	0.0305220829959651	155	NA	FT		ENDOPLASMIC RETICULUM		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR056C is not an essential protein	biological_process	molecular_function	endoplasmic reticulum
YDR011W	YDR011W	SNQ2	hom	Verified	1.80815017207064	0.0352915656467166	no	316	0.0635397807962512	347	NA	FF|FT	NUCLEOTIDE METABOLISM	MITOCHONDRION|PLASMA MEMBRANE		Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species	response to drug	xenobiotic-transporting ATPase activity	mitochondrion|integral to membrane|plasma membrane
YDL200C	YDL200C	MGT1	hom	Verified	1.807882910443	0.0353123630393408	no	317	0.0494800697888442	227	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		DNA repair methyltransferase (6-O-methylguanine-DNA methylase) involved in protection against DNA alkylation damage	DNA dealkylation involved in DNA repair	methylated-DNA-[protein]-cysteine S-methyltransferase activity	nucleus
YDL134C	YDL134C	PPH21	hom	Verified	1.80617029828791	0.0354458714169126	no	318	0.0235410262454916	151	NA	FT	CELL CYCLE|TRANSLATION|CELL DIVISION|CYTOSKELETON ORGANIZATION			Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; forms nuclear foci upon DNA replication stress; PPH21 has a paralog, PPH22, that arose from the whole genome duplication	actin filament organization|budding cell bud growth|protein dephosphorylation|G1/S transition of mitotic cell cycle|mitotic cell cycle spindle assembly checkpoint|regulation of translation	protein serine/threonine phosphatase activity	protein phosphatase type 2A complex
YDL101C	YDL101C	DUN1	hom	Verified	1.78945282346594	0.036770959352095	no	319	0.0458642001016604	288	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION	NUCLEUS		Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; also regulates postreplicative DNA repair	protein phosphorylation|replication fork protection|cell cycle checkpoint|DNA damage checkpoint	protein kinase activity	nucleus
YDR214W	YDR214W	AHA1	hom	Verified	1.78936393263789	0.0367781119759449	no	320	0.0431463769991406	202	NA	FT	NUCLEOTIDE METABOLISM			Co-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is regulated by stresses such as heat shock; protein abundance increases in response to DNA replication stress	protein folding|response to stress	ATPase activator activity|chaperone binding	cytoplasm
YDR494W	YDR494W	RSM28	hom	Verified	1.78887310384709	0.036817627133142	no	321	0.040412258979241	238	NA	FT	TRANSLATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit; genetic interactions suggest a possible role in promoting translation initiation	cytoplasmic translation|translational initiation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YOR136W	YOR136W	IDH2	hom	Verified	1.78485599957401	0.0371423386248127	no	322	0.0560347814138165	303	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylated	glutamate biosynthetic process|isocitrate metabolic process|tricarboxylic acid cycle	isocitrate dehydrogenase (NAD+) activity	mitochondrial isocitrate dehydrogenase complex (NAD+)|mitochondrion|mitochondrial matrix
YBR187W_p	YBR187W	GDT1	hom	Uncharacterized	1.78377621360116	0.0372300180893318	no	323	0.0407523462311649	251	NA					Putative protein of unknown function; expression is reduced in a gcr1 null mutant; GFP-fusion protein localizes to the vacuole; expression pattern and physical interactions suggest a possible role in ribosome biogenesis	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YKL222C	YKL222C	YKL222C	hom	Verified	1.77926652236176	0.0375980383840709	no	324	0.0394197047979999	217	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS|CYTOSKELETON		Protein of unknown function that may interact with ribosomes, based on co-purification experiments; similar to transcriptional regulators from the zinc cluster (binuclear cluster) family; null mutant is sensitive to caffeine	biological_process	sequence-specific DNA binding	ribosome|nucleus|mitotic spindle
YDL099W	YDL099W	BUG1	hom	Verified	1.77243368280336	0.0381612973385076	no	325	0.0202574944376201	126	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	GOLGI APPARATUS		Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes	protein secretion|ER to Golgi vesicle-mediated transport	molecular_function	cis-Golgi network|cytoplasm
YDR309C	YDR309C	GIC2	hom	Verified	1.77177692869534	0.0382157968959624	no	326	0.0274089994808307	144	NA	FT	CELL CYCLE|SIGNALING|CELL DIVISION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON		Redundant rho-like GTPase Cdc42p effector; homolog of Gic1p; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region	regulation of exit from mitosis|establishment of cell polarity|axial cellular bud site selection|Rho protein signal transduction	Rho GTPase binding|Rho GTPase activator activity|phosphatidylinositol-4,5-bisphosphate binding	incipient cellular bud site|actin cap|plasma membrane|mating projection tip|cellular bud tip
YIR020C_p	YIR020C	YIR020C	hom	Uncharacterized	1.77081244923515	0.0382959475186755	no	327	0.0225109525335532	144	NA					Protein of unknown function; mRNA identified as translated by ribosome profiling data	biological_process	molecular_function	cellular_component
YDL180W_p	YDL180W	YDL180W	hom	Uncharacterized	1.76640984361812	0.0386635574188683	no	328	0.0373187029839966	176	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YDR097C	YDR097C	MSH6	hom	Verified	1.76408254632397	0.0388590412740096	no	329	0.0229784341144459	131	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; also involved in interstrand cross-link repair; potentially phosphorylated by Cdc28p	mismatch repair|meiotic mismatch repair	guanine/thymine mispair binding|four-way junction DNA binding|ATPase activity|single base insertion or deletion binding|ATP binding	MutSalpha complex|nucleus
YMR084W_p	YMR084W	YMR084W	hom	Uncharacterized	1.75748598818439	0.0394175040437055	no	330	0.0432203049417615	261	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Putative protein of unknown function; YMR084W and adjacent ORF YMR085W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1	biological_process	molecular_function	cellular_component
YDR009W	YDR009W	GAL3	hom	Verified	1.75536601934508	0.0395983602676954	no	331	0.024342113197038	125	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Transcriptional regulator; involved in activation of the GAL genes in response to galactose; forms a complex with Gal80p to relieve Gal80p inhibition of Gal4p; binds galactose and ATP but does not have galactokinase activity; GAL3 has a paralog, GAL1, that arose from the whole genome duplication	maintenance of protein location|galactose metabolic process|positive regulation of transcription from RNA polymerase II promoter by galactose	protein binding	nucleus|cytoplasm
YGR143W	YGR143W	SKN1	hom	Verified	1.75281396197056	0.0398169728885766	no	332	0.0558731915065635	221	NA	FT	LIPID METABOLISM|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Protein involved in sphingolipid biosynthesis; type II membrane protein with similarity to Kre6p	fungal-type cell wall organization|(1->6)-beta-D-glucan biosynthetic process|sphingolipid biosynthetic process	glucosidase activity	integral to membrane
YGR142W	YGR142W	BTN2	hom	Verified	1.74454797444854	0.0405317918048505	no	333	0.0386858586971697	217	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ION HOMEOSTASIS|ION HOMEOSTASIS			v-SNARE binding protein; facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase; BTN2 has a paralog, CUR1, that arose from the whole genome duplication	intracellular protein transport|amino acid transport|retrograde transport, endosome to Golgi|regulation of pH	SNARE binding	cytosol|late endosome|perinuclear region of cytoplasm
YLR345W_p	YLR345W	YLR345W	hom	Uncharacterized	1.74005983989163	0.0409242555449618	no	334	0.0438050979796626	205	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Similar to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase enzymes responsible for the metabolism of fructoso-2,6-bisphosphate; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene	regulation of glycolysis|fructose 2,6-bisphosphate metabolic process	6-phosphofructo-2-kinase activity	cytoplasm
YOL137W	YOL137W	BSC6	hom	Verified	1.73371742975344	0.0414841161904276	no	335	0.0448900336961552	200	NA	FT		GOLGI APPARATUS		Protein of unknown function containing 8 putative transmembrane seqments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression	biological_process	molecular_function	COPI-coated vesicle|integral to membrane|clathrin-coated vesicle
YGL071W	YGL071W	AFT1	hom	Verified	1.73334557682636	0.0415171322521093	no	336	0.144987308906158	569	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|ION HOMEOSTASIS|ION HOMEOSTASIS|RESPONSE TO NUTRIENT LEVELS|CHROMOSOME SEGREGATION	NUCLEUS		Transcription factor involved in iron utilization and homeostasis; binds consensus site PyPuCACCCPu and activates transcription in response to changes in iron availability; in iron-replete conditions activity is negatively regulated by Grx3p, Grx4p, and Fra2p, which regulate Aft1p translocation from the nucleus to the cytoplasm; AFT1 has a paralog, AFT2, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress	positive regulation of transcription from RNA polymerase II promoter in response to iron ion starvation|meiotic chromosome segregation|positive regulation of iron ion transport|establishment of mitotic sister chromatid cohesion|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding	nucleus|cytoplasm
YKL198C	YKL198C	PTK1	hom	Verified	1.72244490803673	0.0424944772763731	no	337	0.0487685053217482	220	NA	FT	PROTEIN PHOSPHORYLATION			Putative serine/threonine protein kinase that regulates spermine uptake; involved in polyamine transport; possible mitochondrial protein	polyamine transport	protein kinase activity	cellular_component
YIL037C	YIL037C	PRM2	hom	Verified	1.72149507687494	0.0425805123854119	no	338	0.0459794146456684	240	NA					Pheromone-regulated protein, predicted to have 4 transmembrane segments and a coiled coil domain; regulated by Ste12p; required for efficient nuclear fusion	karyogamy involved in conjugation with cellular fusion	molecular_function	integral to membrane
YDR493W	YDR493W	MZM1	hom	Verified	1.71997220959129	0.0427187466379882	no	339	0.0400710402661313	259	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Protein required for assembly of the cytochrome bc(1) complex; acts as a chaperone for Rip1p and facilitates its insertion into the complex at a late stage of assembly; localized to the mitochondrial matrix; null mutant exhibits a respiratory growth defect and reduced mitochondrial zinc levels, which is characteristic of mutations affecting bc(1) complex assembly; human LYRM7 is a functional ortholog	mitochondrial respiratory chain complex III assembly	molecular_function	mitochondrion|mitochondrial matrix
YLR335W	YLR335W	NUP2	hom	Verified	1.71927957361676	0.0427817387475998	no	340	0.0424069443373765	227	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION|GENE SILENCING	ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION|CHROMOSOME	NUCLEAR PORE	Nucleoporin involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization	rRNA export from nucleus|snRNA export from nucleus|nuclear pore organization|tRNA export from nucleus|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|mRNA-binding (hnRNP) protein import into nucleus|ribosomal protein import into nucleus|snRNP protein import into nucleus|chromatin silencing at telomere|chromatin silencing at silent mating-type cassette|protein targeting to membrane|poly(A)+ mRNA export from nucleus|protein export from nucleus|mRNA export from nucleus in response to heat stress|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery|NLS-bearing substrate import into nucleus|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, non-stop decay	nucleocytoplasmic transporter activity	nuclear chromatin|mitochondrion|integral to membrane|nuclear pore
YIR038C	YIR038C	GTT1	hom	Verified	1.71702040071538	0.0429877222839899	no	341	0.0471047916021333	206	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p	glutathione metabolic process	glutathione transferase activity|glutathione peroxidase activity	mitochondrial outer membrane|mitochondrion|endoplasmic reticulum|plasma membrane
YOL092W	YOL092W	YPQ1	hom	Verified	1.71359668693822	0.0433014112233151	no	342	0.0348878517203738	207	NA					Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter	biological_process	molecular_function	fungal-type vacuole membrane|integral to membrane|cytoplasm
YLR148W	YLR148W	PEP3	hom	Verified	1.71116396068432	0.0435254247818558	no	343	0.102367261759263	433	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT			Component of CORVET tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis	regulation of SNARE complex assembly|regulation of vacuole fusion, non-autophagic|vacuole fusion, non-autophagic|late endosome to vacuole transport|vesicle docking involved in exocytosis|Golgi to endosome transport	phosphatidylinositol binding|protein binding, bridging	fungal-type vacuole membrane|HOPS complex|proteasome storage granule|CORVET complex|extrinsic to vacuolar membrane
YKL206C	YKL206C	ADD66	hom	Verified	1.70969251438079	0.0436613738529921	no	344	0.039414793909767	200	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS			Protein involved in 20S proteasome assembly; forms a heterodimer with Pba1p that binds to proteasome precursors; similar to human PAC2 constituent of the PAC1-PAC2 complex involved in proteasome assembly	proteasome assembly	molecular_function	cytosol|cytoplasm
YDR338C_p	YDR338C	YDR338C	hom	Uncharacterized	1.70950226230306	0.0436789765085093	no	345	0.0574777520111783	211	NA					Putative protein of unknown function, member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily	transmembrane transport	antiporter activity	integral to membrane
YDR249C_p	YDR249C	YDR249C	hom	Uncharacterized	1.70742320701591	0.0438717099756501	no	346	0.0330253951780685	170	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YLR360W	YLR360W	VPS38	hom	Verified	1.70250351888797	0.0443305096952937	no	347	0.0374890213133998	165	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT	GOLGI APPARATUS		Part of a Vps34p phosphatidylinositol 3-kinase complex that functions in carboxypeptidase Y (CPY) sorting; binds Vps30p and Vps34p to promote production of phosphatidylinositol 3-phosphate (PtdIns3P) which stimulates kinase activity; required for overflow degradation of misfolded proteins when ERAD is saturated	ER-associated protein catabolic process|late endosome to vacuole transport	molecular_function	phosphatidylinositol 3-kinase complex II
YIL071C	YIL071C	PCI8	hom	Verified	1.70169068810657	0.0444066834663118	no	348	0.0535224625957059	264	NA	FT		NUCLEUS		Possible shared subunit of Cop9 signalosome (CSN) and eIF3, binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain	cullin deneddylation	molecular_function	signalosome
YDR513W	YDR513W	GRX2	hom	Verified	1.69727048726809	0.0448227671000247	no	349	0.0345849546843091	157	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		Cytoplasmic glutaredoxin; thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity, expression induced in response to stress; GRX2 has a paralog, GRX1, that arose from the whole genome duplication	cellular response to oxidative stress	disulfide oxidoreductase activity|glutathione transferase activity|glutathione peroxidase activity	cytosol|mitochondrion
YDR484W	YDR484W	VPS52	hom	Verified	1.6925210233773	0.0452733375478333	no	350	0.10069846968932	354	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	GOLGI APPARATUS|CYTOSKELETON		Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin	actin filament-based process|Golgi to vacuole transport|retrograde transport, endosome to Golgi	protein binding	Golgi apparatus|GARP complex
YFR053C	YFR053C	HXK1	hom	Verified	1.69247064702729	0.0452781360902568	no	351	0.0558416627030977	248	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Hexokinase isoenzyme 1; a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves hexokinase Hxk2p; HXK1 has a paralog, HXK2, that arose from the whole genome duplication	mannose metabolic process|glucose import|glycolysis|fructose import|glucose metabolic process|fructose metabolic process	hexokinase activity	cytosol|mitochondrion|cytoplasm
YGR161W-C_p	YGR161W-C	YGR161W-C	hom	Uncharacterized	1.6892144324287	0.0455891720944504	no	352	0.0245560217155611	129	NA					Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species	biological_process	molecular_function	cellular_component
YDR368W	YDR368W	YPR1	hom	Verified	1.68663529147449	0.0458367507838603	no	353	0.0426001145284848	211	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		NADPH-dependent aldo-keto reductase; reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases; protein abundance increases in response to DNA replication stress; YPR1 has a paralog, GCY1, that arose from the whole genome duplication	cellular response to oxidative stress|D-xylose catabolic process|arabinose catabolic process	glucose 1-dehydrogenase (NADP+) activity|alditol:NADP+ 1-oxidoreductase activity|carbonyl reductase (NADPH) activity	nucleus|cytoplasm
YMR144W_p	YMR144W	YMR144W	hom	Uncharacterized	1.68621646956873	0.0458770564129431	no	354	0.042591447957293	220	NA	FT		NUCLEUS		Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene	biological_process	molecular_function	nucleus
YJR120W	YJR120W	YJR120W	hom	Verified	1.6834391069603	0.0461450590376299	no	355	0.0446102147932715	193	NA	FT	OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY			Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p	cellular respiration|sterol transport|mitochondrion organization	molecular_function	cellular_component
YDR290W_d	YDR290W	YDR290W	hom	Dubious	1.68315942668976	0.0461721164318502	no	356	0.0742807311194279	312	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RTT103	Unknown	Unknown	Unknown
YDR019C	YDR019C	GCV1	hom	Verified	1.68315742190291	0.046172310428977	no	357	0.0545790359182791	244	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		T subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm	glycine catabolic process|glycine metabolic process|one-carbon metabolic process	glycine dehydrogenase (decarboxylating) activity	mitochondrion|glycine cleavage complex
YKL015W	YKL015W	PUT3	hom	Verified	1.68300851815475	0.046186721221955	no	358	0.0317407390131204	163	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Transcriptional activator of proline utilization genes, constitutively binds PUT1 and PUT2 promoter sequences as a dimer and undergoes a conformational change to form the active state; differentially phosphorylated in the presence of different nitrogen sources; has a Zn(2)-Cys(6) binuclear cluster domain	Unknown|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YJR115W_p	YJR115W	YJR115W	hom	Uncharacterized	1.68177525096936	0.0463062147882316	no	359	0.0353591445529536	193	NA					Putative protein of unknown function; YJR115W has a paralog, ECM13, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YKL076C_d	YKL076C	PSY1	hom	Dubious	1.67705825287109	0.046765545622062	no	360	0.0492282002353011	261	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C	Unknown	Unknown	Unknown
YDR286C_p	YDR286C	YDR286C	hom	Uncharacterized	1.67422521467915	0.0470431728874879	no	361	0.0306528967839342	132	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY			Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site	biological_process	molecular_function	cellular_component
YER137C_p	YER137C	YER137C	hom	Uncharacterized	1.67265545896055	0.0471975711932036	no	362	0.050399807951041	258	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YDR458C	YDR458C	HEH2	hom	Verified	1.67163587413156	0.0472980731072478	no	363	0.0513020132164778	249	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS		Inner nuclear membrane (INM) protein; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence; targeting to the INM requires the Srp1p-Kap95p karyopherins and the Ran cycle	biological_process	molecular_function	nuclear envelope
YDR420W	YDR420W	HKR1	hom	Verified	1.67005005059356	0.0474547307313398	no	364	0.0292131322595437	147	NA	FT	CELL CYCLE|SIGNALING|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Mucin family member that functions as an osmosensor in the Sho1p-mediated HOG pathway with Msb2p; proposed to be a negative regulator of filamentous growth; mutant displays defects in beta-1,3 glucan synthesis and bud site selection	(1->3)-beta-D-glucan biosynthetic process|fungal-type cell wall organization|osmosensory signaling pathway via Sho1 osmosensor|hyperosmotic response|cellular bud site selection	osmosensor activity	site of polarized growth|plasma membrane
YOR109W	YOR109W	INP53	hom	Verified	1.66855478723637	0.0476028227723672	no	365	0.044025191948756	240	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION	CYTOSKELETON		Polyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains	phosphatidylinositol dephosphorylation	phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|phosphatidylinositol-3-phosphatase activity|phosphatidylinositol-4-phosphate phosphatase activity	membrane|actin cortical patch|cytoplasm
YPR084W_p	YPR084W	YPR084W	hom	Uncharacterized	1.66636502467902	0.0478203662981733	no	366	0.0457107984349051	236	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YGR212W	YGR212W	SLI1	hom	Verified	1.66632104984075	0.0478247431491943	no	367	0.051878870935491	235	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin	response to drug	N-acetyltransferase activity	nuclear envelope|plasma membrane
YDL124W	YDL124W	YDL124W	hom	Verified	1.66613852082633	0.0478429138375163	no	368	0.0296232601405206	182	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		NADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress	cellular response to oxidative stress|cellular ketone metabolic process|cellular amide metabolic process|cellular aromatic compound metabolic process	alpha-keto amide reductase activity|aldo-keto reductase (NADP) activity|alditol:NADP+ 1-oxidoreductase activity|alpha-keto ester reductase activity	nucleus|plasma membrane|cytoplasm
YKL039W	YKL039W	PTM1	hom	Verified	1.66347188808976	0.0481090067693129	no	369	0.0424408947408593	206	NA	FT		ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Protein of unknown function; copurifies with late Golgi vesicles containing the v-SNARE Tlg2p; PTM1 has a paralog, YHL017W, that arose from the whole genome duplication	biological_process	molecular_function	integral to membrane
YDL175C	YDL175C	AIR2	hom	Verified	1.65859114282524	0.0485991038867919	no	370	0.0552536430056257	233	NA	FT	RNA PROCESSING	NUCLEUS		RNA-binding subunit of the TRAMP nuclear RNA surveillance complex; involved in nuclear RNA processing and degradation; involved in TRAMP complex assembly as a bridge between Mtr4p and Trf4p; stimulates the poly(A) polymerase activity of Pap2p in vitro; has 5 zinc knuckle motifs; AIR2 has a paralog, AIR1, that arose from the whole genome duplication	nuclear polyadenylation-dependent CUT catabolic process|nuclear mRNA surveillance of mRNA 3'-end processing|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent snRNA catabolic process|ncRNA polyadenylation|tRNA modification	polynucleotide adenylyltransferase activity|RNA binding|protein binding, bridging	nucleolus|TRAMP complex
YCR095W-A_p	YCR095W-A	YCR095W-A	hom	Uncharacterized	1.65741996728742	0.0487172986279604	no	371	0.0424100482975787	198	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YNL157W	YNL157W	IGO1	hom	Verified	1.65721284522178	0.0487382252251607	no	372	0.0203511402469806	126	NA	FT		NUCLEUS		Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; similar to Igo2p	mRNA stabilization	molecular_function	nucleus|cytoplasmic mRNA processing body|cytoplasm
YGL232W	YGL232W	TAN1	hom	Verified	1.6556630935543	0.0488950326173136	no	373	0.0522936427933719	232	NA	FT	RNA PROCESSING	NUCLEUS		Putative tRNA acetyltransferase; RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA; protein abundance increases in response to DNA replication stress	tRNA modification	RNA binding	nucleus|cytoplasm
YOL140W	YOL140W	ARG8	hom	Verified	1.65401957991805	0.0490617672341559	no	374	0.0353860914605816	170	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine	arginine biosynthetic process|ornithine biosynthetic process	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity	mitochondrion|mitochondrial matrix
YGR208W	YGR208W	SER2	hom	Verified	1.65336765201358	0.0491280310636137	no	375	0.0415824255655739	213	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source	L-serine biosynthetic process	phosphoserine phosphatase activity	nucleus|cytoplasm
YOR073W	YOR073W	SGO1	hom	Verified	1.65033917603214	0.0494367919269534	no	376	0.0642596593258547	261	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME|CYTOSKELETON	KINETOCHORE	Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability	positive regulation of maintenance of meiotic sister chromatid cohesion|meiotic sister chromatid segregation|meiotic sister chromatid separation|sister chromatid biorientation|maintenance of meiotic sister chromatid cohesion|mitotic cell cycle spindle assembly checkpoint|mitotic sister chromatid segregation	molecular_function	condensed nuclear chromosome kinetochore|nucleus|spindle pole body|condensed nuclear chromosome, centromeric region
YHR181W	YHR181W	SVP26	hom	Verified	1.65025820453902	0.0494450683902548	no	377	0.0539840337195454	232	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment	protein retention in Golgi apparatus|fungal-type cell wall organization|protein glycosylation|ER to Golgi vesicle-mediated transport	COPII adaptor activity	integral to endoplasmic reticulum membrane|integral to membrane|endoplasmic reticulum|integral to Golgi membrane|ER to Golgi transport vesicle
YDR020C_p	YDR020C	DAS2	hom	Uncharacterized	1.64964431329805	0.0495078529824355	no	378	0.0368173147766703	204	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases	biological_process	molecular_function	nucleus|cytoplasm
YDL162C_d	YDL162C	YDL162C	hom	Dubious	1.64939259338914	0.0495336155586394	no	379	0.0451558341290515	215	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps ENT1/YDL161W, a verified gene involved in endocytosis and actin cortical patch assembly	Unknown	Unknown	Unknown
YNL052W	YNL052W	COX5A	hom	Verified	1.6490935822231	0.0495642321177247	no	380	0.036866042481245	200	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Subunit Va of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Ap is predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth; COX5A has a paralog, COX5B, that arose from the whole genome duplication	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YNL200C	YNL200C	YNL200C	hom	Verified	1.64693728338738	0.0497854687570479	no	381	0.0369024751697141	179	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		NADHX epimerase; catalyzes isomerization of (R)- and (S)-NADHX; homologous to AIBP in mammals and the N- terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	nicotinamide nucleotide metabolic process	NADHX epimerase activity	mitochondrion|cytoplasm
YER161C	YER161C	SPT2	hom	Verified	1.64288139595769	0.0502037374612173	no	382	0.070135974645206	316	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|CHROMATIN ORGANIZATION	NUCLEUS		Protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components, has similarity to mammalian HMG1 proteins	negative regulation of transcription from RNA polymerase II promoter|chromatin organization|RNA polyadenylation|transcription elongation from RNA polymerase II promoter	DNA binding|DNA secondary structure binding	nucleus
YML007C-A_p	YML007C-A	YML007C-A	hom	Uncharacterized	1.6418711930378	0.0503083504890608	no	383	0.0680509736348676	406	NA	FF|FT		MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria	biological_process	molecular_function	mitochondrion
YDR183W	YDR183W	PLP1	hom	Verified	1.64136989271893	0.050360327828391	no	384	0.0434711118646248	204	NA	FT	TRANSCRIPTION FROM RNA POL II|SIGNALING			Protein that interacts with CCT (chaperonin containing TCP-1) complex and has a role in actin and tubulin folding; has weak similarity to phosducins, which are G-protein regulators	protein folding|positive regulation of transcription from RNA polymerase II promoter by pheromones	G-protein beta/gamma-subunit complex binding	cellular_component
YMR086C-A_d	YMR086C-A	YMR086C-A	hom	Dubious	1.64129674895574	0.0503679153180647	no	385	0.0467398745087064	247	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YER095W	YER095W	RAD51	hom	Verified	1.63449711970222	0.0510772552702502	no	386	0.0740791822537193	337	NA	FF|FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein	strand invasion|telomere maintenance via recombination|heteroduplex formation|meiotic joint molecule formation|reciprocal meiotic recombination|double-strand break repair via single-strand annealing	recombinase activity|single-stranded DNA binding|DNA-dependent ATPase activity	condensed nuclear chromosome|nuclear chromosome
YDL171C	YDL171C	GLT1	hom	Verified	1.63369975967876	0.0511609544314407	no	387	0.0444902899209735	192	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		NAD(+)-dependent glutamate synthase (GOGAT), synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source	glutamate biosynthetic process|ammonia assimilation cycle	glutamate synthase (NADH) activity	mitochondrion
YNL119W	YNL119W	NCS2	hom	Verified	1.63308084593063	0.0512259972288613	no	388	0.0504070322083841	245	NA	FT	RNA PROCESSING			Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae	tRNA wobble position uridine thiolation|pseudohyphal growth|protein urmylation|invasive growth in response to glucose limitation	molecular_function	cytosol|cytoplasm
YKL109W	YKL109W	HAP4	hom	Verified	1.62699594460089	0.0518689795490937	no	389	0.0530797623187045	251	NA	FT	TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex	regulation of cellular respiration|carbon catabolite activation of transcription from RNA polymerase II promoter	RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor binding transcription factor activity	CCAAT-binding factor complex
YDL240W	YDL240W	LRG1	hom	Verified	1.6258687001202	0.0519887949131875	no	390	0.0528837468156188	263	NA	FT	SIGNALING|CELL WALL ORG/BIOGENESIS	MITOCHONDRION|SITE OF POLARIZED GROWTH		Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity; appears to specifically regulate 1,3-beta-glucan synthesis	fungal-type cell wall biogenesis|small GTPase mediated signal transduction	Rho GTPase activator activity	mitochondrion|cellular bud neck|cytoplasm
YDR305C	YDR305C	HNT2	hom	Verified	1.62236307512057	0.0523628152593225	no	391	0.0395426617593307	206	NA	FT		NUCLEUS|MITOCHONDRION		Dinucleoside triphosphate hydrolase; has similarity to the tumor suppressor FHIT and belongs to the histidine triad (HIT) superfamily of nucleotide-binding proteins	nucleoside catabolic process	hydrolase activity|nucleoside-triphosphatase activity	mitochondrion|nucleus|cytoplasm
YGL104C	YGL104C	VPS73	hom	Verified	1.6217029129191	0.0524334874069805	no	392	0.0632588095962293	251	NA	FT	PROTEIN LOCALIZATION|VACUOLAR TRANSPORT	MITOCHONDRION		Mitochondrial protein; mutation affects vacuolar protein sorting; putative transporter; member of the sugar porter family	transport|transmembrane transport|protein targeting to vacuole	substrate-specific transmembrane transporter activity	mitochondrion|integral to membrane
YOR076C	YOR076C	SKI7	hom	Verified	1.6194043203958	0.052680148938902	no	393	0.0576653543607897	251	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM			Coupling protein that mediates interactions between the Ski complex and the cytoplasmic exosome during 3'-5' RNA degradation; eRF3-like domain targets nonstop mRNA for degradation; null mutants have superkiller phenotype	nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, non-stop decay|nonfunctional rRNA decay	protein binding, bridging	Ski complex|cytoplasmic exosome (RNase complex)|cytoplasm
YKL110C	YKL110C	KTI12	hom	Verified	1.61708556413884	0.0529299062542076	no	394	0.0635968519720498	285	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p	regulation of transcription from RNA polymerase II promoter|cell growth|tRNA wobble uridine modification	chromatin binding	nucleus|cytoplasm
YGR193C	YGR193C	PDX1	hom	Verified	1.61638853308017	0.053005168010977	no	395	0.035368557352159	155	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core	acetyl-CoA biosynthetic process from pyruvate	structural molecule activity	mitochondrion|mitochondrial pyruvate dehydrogenase complex
YFR011C	YFR011C	AIM13	hom	Verified	1.61588233397597	0.0530598779116582	no	396	0.0405232546007602	233	NA	FT	MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial protein peripheral to the inner membrane; component of the mitochondrial inner membrane organizing system (MINOS, MitOS, or MICOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture	cristae formation	molecular_function	mitochondrion|extrinsic to mitochondrial inner membrane|mitochondrial crista junction|cytoplasm|mitochondrial intermembrane space
YDR144C	YDR144C	MKC7	hom	Verified	1.61547702421007	0.0531037159849894	no	397	0.0448857335163588	242	NA	FT	CELL WALL ORG/BIOGENESIS|PROTEOLYSIS	PLASMA MEMBRANE		GPI-anchored aspartyl protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; shares functions with Yap3p and Kex2p	proteolysis|fungal-type cell wall organization	aspartic-type endopeptidase activity	fungal-type cell wall
YNL093W	YNL093W	YPT53	hom	Verified	1.61006021792056	0.0536923553937239	no	398	0.0758265521214771	368	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|VACUOLAR TRANSPORT	PLASMA MEMBRANE		Rab family GTPase; similar to Ypt51p and Ypt52p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; YPT53 has a paralog, VPS21, that arose from the whole genome duplication	endocytosis|protein targeting to vacuole	GTPase activity	late endosome
YDR384C	YDR384C	ATO3	hom	Verified	1.60744419950978	0.0539784804100766	no	399	0.0472071563651007	202	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION|PLASMA MEMBRANE		Plasma membrane protein, regulation pattern suggests a possible role in export of ammonia from the cell; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family of putative transporters	ammonium transport|nitrogen utilization|transmembrane transport	ammonium transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YIL043C	YIL043C	CBR1	hom	Verified	1.60346251762309	0.0544162890234797	no	400	0.0624680520044658	298	NA	FT	OXIDATION-REDUCTION PROCESS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		Microsomal cytochrome b reductase, not essential for viability; also detected in mitochondria; mutation in conserved NADH binding domain of the human ortholog results in type I methemoglobinemia	biological_process	cytochrome-b5 reductase activity	mitochondrial outer membrane|mitochondrion
YPR004C	YPR004C	AIM45	hom	Verified	1.60100363608141	0.0546880569016832	no	401	0.0524488446411822	287	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-alpha; interacts with frataxin, Yfh1p; null mutant displays elevated frequency of mitochondrial genome loss; may have a role in oxidative stress response	biological_process	molecular_function	mitochondrion
YOR292C_p	YOR292C	YOR292C	hom	Uncharacterized	1.59604115435749	0.055239802672896	no	402	0.0416610191181682	200	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YOR292C is not an essential gene	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YLR431C	YLR431C	ATG23	hom	Verified	1.59453114506144	0.0554085603377299	no	403	0.0653861457395538	304	NA	FT	PROTEIN LOCALIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Peripheral membrane protein required for the cytoplasm-to-vacuole targeting (Cvt) pathway and efficient macroautophagy; cycles between the phagophore assembly site (PAS) and non-PAS locations; forms a complex with Atg9p and Atg27p	protein localization to pre-autophagosomal structure|positive regulation of macroautophagy|CVT pathway	molecular_function	pre-autophagosomal structure|extrinsic to membrane
YOL013W-A_p	YOL013W-A	YOL013W-A	hom	Uncharacterized	1.59261055972228	0.0556237915713325	no	404	0.0527319705710436	233	NA					Putative protein of unknown function; identified by SAGE	biological_process	molecular_function	integral to membrane
YDR199W_d	YDR199W	YDR199W	hom	Dubious	1.59194412703289	0.055698629668029	no	405	0.0716863270804761	285	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity	Unknown	Unknown	Unknown
YPL001W	YPL001W	HAT1	hom	Verified	1.59164112619422	0.0557326818857899	no	406	0.068339329906319	252	NA	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS	HISTONE ACETYLTRANSFERASE	Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A, to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair	histone acetylation|chromatin silencing at telomere	histone acetyltransferase activity|histone binding	histone acetyltransferase complex|nucleus|cytoplasm
YOL107W_p	YOL107W	YOL107W	hom	Uncharacterized	1.5891810717236	0.0560097592864212	no	407	0.0480109146299705	259	NA	FT		ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and colocalizes in a punctate pattern with the early golgi/COPI vesicles; YOL107W is not an essential protein	biological_process	molecular_function	COPI-coated vesicle|Golgi apparatus
YHL031C	YHL031C	GOS1	hom	Verified	1.58881138402486	0.0560514911754365	no	408	0.115535015942137	476	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28	Golgi vesicle transport|vesicle fusion	SNAP receptor activity	SNARE complex|integral to membrane|Golgi medial cisterna
YEL051W	YEL051W	VMA8	hom	Verified	1.58857010969142	0.0560787404507034	no	409	0.0726095184568783	283	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Subunit D of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis	vacuolar acidification	proton-transporting ATPase activity, rotational mechanism	fungal-type vacuole membrane|vacuolar proton-transporting V-type ATPase, V1 domain|integral to membrane
YPR128C	YPR128C	ANT1	hom	Verified	1.58809546757942	0.0561323765335484	no	410	0.0627226786856503	315	NA	FT	KETONE METABOLISM|LIPID METABOLISM|ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|PEROXISOME ORGANIZATION			Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation	ATP transport|fatty acid beta-oxidation|peroxisome organization	adenine nucleotide transmembrane transporter activity	integral to membrane|cytoplasm|integral to peroxisomal membrane
YJL205C	YJL205C	NCE101	hom	Verified	1.5879863332519	0.0561447147812008	no	411	0.0464507794286845	235	NA	FT	PROTEIN LOCALIZATION			Protein of unknown function, involved in secretion of proteins that lack classical secretory signal sequences	protein secretion	molecular_function	cellular_component
YGR059W	YGR059W	SPR3	hom	Verified	1.58280529492132	0.0567329247541393	no	412	0.0539304849329666	260	NA	FT	CELL CYCLE	SITE OF POLARIZED GROWTH|CYTOSKELETON		Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; septin protein involved in sporulation; regulated by ABFI	ascospore formation	structural molecule activity	septin complex|ascospore wall|prospore membrane
YHR162W	YHR162W	MPC2	hom	Verified	1.57593557538729	0.0575203256208883	no	413	0.0573831783400727	271	NA					Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; more highly expressed in glucose-containing minimal medium than in lactate-containing medium	mitochondrial pyruvate transport	pyruvate transmembrane transporter activity	mitochondrion|integral to mitochondrial inner membrane
YHR146W	YHR146W	CRP1	hom	Verified	1.57260836995084	0.0579047642058222	no	414	0.0708117226808107	312	NA	FT		NUCLEUS		Protein that binds to cruciform DNA structures	biological_process	DNA binding	nucleus
YGL014W	YGL014W	PUF4	hom	Verified	1.57190437445017	0.0579863649524905	no	415	0.0805889015528332	349	NA	FT	PROTEIN LOCALIZATION|CHROMATIN ORGANIZATION|TRANSLATION|GENE SILENCING			Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|negative regulation of translation|protein localization|negative regulation of chromatin silencing involved in replicative cell aging	mRNA binding	cytoplasm
YDR340W_d	YDR340W	YDR340W	hom	Dubious	1.57123752633352	0.0580637432368018	no	416	0.0424555287865682	195	NA					Putative protein of unknown function	Unknown	Unknown	Unknown
YFL023W	YFL023W	BUD27	hom	Verified	1.56931126684316	0.0582877141443933	no	417	0.0609596829946108	339	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION		RIBOSOME	Unconventional prefoldin protein involved in translation initiation; mutants have inappropriate expression of nutrient sensitive genes due to translational derepression of Gcn4p transcription factor; diploid mutants show random budding; ortholog of human URI/RMP	formation of translation preinitiation complex	molecular_function	cytosolic ribosome|cytoplasm
YDL213C	YDL213C	NOP6	hom	Verified	1.56657896223077	0.0586065692202145	no	418	0.0643691974065978	290	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		rRNA-binding protein required for 40S ribosomal subunit biogenesis; contains an RNA recognition motif (RRM); hydrophilin essential to overcome the stress of the desiccation-rehydration process; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes	ribosomal small subunit biogenesis	RNA binding|rRNA binding	nucleolus|90S preribosome
YJL024C	YJL024C	APS3	hom	Verified	1.56424554525278	0.0588799574904951	no	419	0.0720928502917395	328	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress	Golgi to vacuole transport|vesicle-mediated transport	molecular_function	AP-3 adaptor complex
YER098W	YER098W	UBP9	hom	Verified	1.56138935862505	0.0592159555653023	no	420	0.0707958400510309	323	NA	FT	PROTEOLYSIS			Ubiquitin-specific protease that cleaves ubiquitin-protein fusions; UBP9 has a paralog, UBP13, that arose from the whole genome duplication	protein deubiquitination	ubiquitin-specific protease activity	cytoplasm
YGR129W	YGR129W	SYF2	hom	Verified	1.56021124303082	0.0593549848020383	no	421	0.0764901733039649	326	NA	FT	RNA PROCESSING	NUCLEUS		Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; isy1 syf2 cells have defective spindles activiating cell cycle arrest	mRNA splicing, via spliceosome	first spliceosomal transesterification activity|second spliceosomal transesterification activity	U2-type post-mRNA release spliceosomal complex|Prp19 complex|U2-type prespliceosome|U2-type catalytic step 2 spliceosome|U2-type catalytic step 1 spliceosome
YCL005W-A	YCL005W-A	VMA9	hom	Verified	1.55983868007812	0.0593990041189727	no	422	0.0830052667699505	392	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS			Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex; essential for vacuolar acidification; interacts with the V-ATPase assembly factor Vma21p in the ER; involved in V0 biogenesis	cell wall mannoprotein biosynthetic process|vacuolar acidification|protein complex assembly|transmembrane transport	ATPase activity, coupled to transmembrane movement of ions	vacuolar proton-transporting V-type ATPase, V0 domain|fungal-type vacuole membrane
YJL186W	YJL186W	MNN5	hom	Verified	1.55969711550759	0.0594157370628312	no	423	0.0417456153542136	227	NA	FT	CARBOHYDRATE METABOLISM	GOLGI APPARATUS		Alpha-1,2-mannosyltransferase, responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment	protein glycosylation	alpha-1,2-mannosyltransferase activity	Golgi apparatus
YKR088C	YKR088C	TVP38	hom	Verified	1.55913226228687	0.0594825395498661	no	424	0.0604074708147687	301	NA	FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|CYTOSKELETON ORGANIZATION	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; required for asymmetric localization of Kar9p during mitosis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern	vesicle-mediated transport|mitotic spindle elongation	molecular_function	integral to membrane|integral to Golgi membrane|cytoplasm
YPR042C	YPR042C	PUF2	hom	Verified	1.55488816630451	0.0599863530940057	no	425	0.069127504874218	342	NA					Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding membrane-associated proteins	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	mRNA binding	cytoplasm
YKL100C_p	YKL100C	YKL100C	hom	Uncharacterized	1.55433717063422	0.0600520057568689	no	426	0.0395077920177862	174	NA	FT	PROTEOLYSIS			Putative protein of unknown function with similarity to a human minor histocompatibility antigen and signal peptide peptidases; YKL100C is not an essential gene	biological_process	molecular_function	integral to membrane
YNL202W	YNL202W	SPS19	hom	Verified	1.55364748840204	0.0601342625825479	no	427	0.0752906814650528	350	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS			Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate	fatty acid catabolic process|ascospore formation	2,4-dienoyl-CoA reductase (NADPH) activity	peroxisomal matrix
YOR276W	YOR276W	CAF20	hom	Verified	1.55208802420137	0.0603205815447661	no	428	0.0554079398178376	224	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION			Phosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E	negative regulation of translation|positive regulation of cytoplasmic mRNA processing body assembly	translation regulator activity	mRNA cap binding complex
YDR036C	YDR036C	EHD3	hom	Verified	1.55168236656784	0.0603691219808031	no	429	0.0433179910699735	217	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis	fatty acid beta-oxidation|biological_process	3-hydroxyisobutyryl-CoA hydrolase activity	mitochondrion
YER066W_p	YER066W	RRT13	hom	Uncharacterized	1.54619310867362	0.0610289686688854	no	430	0.0361515832484168	210	NA					Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription	biological_process	molecular_function	cellular_component
YMR087W	YMR087W	YMR087W	hom	Verified	1.54530951653542	0.0611357073405061	no	431	0.059788423500555	293	NA	FT	RNA PROCESSING			Putative ADP-ribose-1''-monophosphatase that converts ADP-ribose-1''-monophosphate to ADP-ribose; may have a role in tRNA splicing; contains an A1pp domain	tRNA splicing, via endonucleolytic cleavage and ligation	phosphatase activity	cellular_component
YOR239W	YOR239W	ABP140	hom	Verified	1.54009902545895	0.0617681086529988	no	432	0.0552214982706249	223	NA	FT	RNA PROCESSING|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		AdoMet-dependent tRNA methyltransferase and actin binding protein; C-terminal domain is responsible for 3-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA-Thr and tRNA-Ser and contains an S-adenosylmethionine (AdoMet) binding motif; N-terminal actin binding sequence interacts with actin filaments and localizes to actin patches and cables; N- and C-terminal domains are encoded in separate ORFs that are translated into one protein via a +1 frameshift	actin filament bundle assembly|tRNA methylation	tRNA (cytosine-3-)-methyltransferase activity|actin filament binding|protein binding, bridging	actin filament|actin filament bundle|mating projection tip|actin cortical patch
YKR106W	YKR106W	GEX2	hom	Verified	1.53852391074358	0.0619602833991316	no	433	0.0523155713512403	218	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Proton:glutathione antiporter localized to the vacuolar and plasma membranes; expressed at a very low level; almost identical to paralog Gex1p; potential role in resistance to oxidative stress and modulation of the PKA pathway	glutathione transmembrane transport	solute:hydrogen antiporter activity	integral to membrane|plasma membrane|vacuolar membrane
YPR068C	YPR068C	HOS1	hom	Verified	1.53713393223011	0.0621302575291084	no	434	0.0440123926240306	241	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS		Class I histone deacetylase (HDAC) family member that deacetylates Smc3p on lysine residues at anaphase onset; has sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; interacts with the Tup1p-Ssn6p corepressor complex	peptidyl-lysine deacetylation|histone H4 deacetylation|positive regulation of transcription from RNA polymerase II promoter	histone deacetylase activity|protein deacetylase activity	histone deacetylase complex
YJR066W	YJR066W	TOR1	hom	Verified	1.53187832677787	0.0627762313553804	no	435	0.048550219090182	242	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RIBOSOME BIOGENESIS|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS|PLASMA MEMBRANE		PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication	regulation of cell cycle|G1 phase of mitotic cell cycle|transcription of nuclear large rRNA transcript from RNA polymerase I promoter|regulation of cell growth|response to DNA damage stimulus|mitochondria-nucleus signaling pathway|ribosome biogenesis|meiosis|signal transduction|TOR signaling cascade|fungal-type cell wall organization|negative regulation of autophagy	protein binding|protein kinase activity	TORC1 complex|fungal-type vacuole membrane|endosome membrane|extrinsic to internal side of plasma membrane|plasma membrane|nucleus|Golgi membrane|cytoplasm
YJR079W_p	YJR079W	YJR079W	hom	Uncharacterized	1.52975462342096	0.0630387386548553	no	436	0.0742990766270823	267	NA					Putative protein of unknown function; mutation results in impaired mitochondrial respiration	biological_process	molecular_function	cellular_component
YOL064C	YOL064C	MET22	hom	Verified	1.52877939117489	0.0631595715275896	no	437	0.0873214612992081	347	NA	FT	KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Bisphosphate-3'-nucleotidase, involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway	methionine biosynthetic process|hyperosmotic salinity response|sulfate assimilation	3'(2'),5'-bisphosphate nucleotidase activity	cellular_component
YDR336W_p	YDR336W	YDR336W	hom	Uncharacterized	1.52849051178775	0.0631953987611959	no	438	0.0713904405168852	296	NA					Putative protein of unknown function; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene	biological_process	molecular_function	cellular_component
YCR075C	YCR075C	ERS1	hom	Verified	1.52766820371884	0.0632974692199746	no	439	0.0533113120418881	278	NA					Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains	L-cystine transport|transmembrane transport	L-cystine transmembrane transporter activity	endosome|integral to membrane|fungal-type vacuole
YPL053C	YPL053C	KTR6	hom	Verified	1.5269738370689	0.063383758629962	no	440	0.0611504294507174	283	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Probable mannosylphosphate transferase; involved in the synthesis of core oligosaccharides in protein glycosylation pathway; member of the KRE2/MNT1 mannosyltransferase family; KTR6 has a paralog, KRE2, that arose from the whole genome duplication	fungal-type cell wall organization|protein N-linked glycosylation	mannosylphosphate transferase activity	membrane
YJL084C	YJL084C	ALY2	hom	Verified	1.52523879142166	0.0635997741795623	no	441	0.0500599145876538	255	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION			Alpha arrestin that controls nutrient-mediated intracellular sorting of permease Gap1p; interacts with AP-1 subunit Apl4p; phosphorylated by Npr1p and also by cyclin-CDK complex Pcl7p-Pho85p; promotes endocytosis of plasma membrane proteins; ALY2 has a paralog, ALY1, that arose from the whole genome duplication	Unknown|regulation of intracellular transport|ubiquitin-dependent endocytosis	protein binding, bridging|ubiquitin protein ligase binding	late endosome|cytoplasm|early endosome
YDR517W	YDR517W	GRH1	hom	Verified	1.52341196020556	0.0638278358083643	no	442	0.0463664646557269	197	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Acetylated cis-Golgi protein, involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes; protein abundance increases in response to DNA replication stress	protein secretion|ER to Golgi vesicle-mediated transport|Golgi organization	molecular_function	COPII vesicle coat|cis-Golgi network|cytoplasm
YGR161C_p	YGR161C	RTS3	hom	Uncharacterized	1.52230884692091	0.0639658561875111	no	443	0.0620092403306168	267	NA	FT		NUCLEUS		Putative component of the protein phosphatase type 2A complex	biological_process	molecular_function	nucleus|cytoplasm
YKL092C	YKL092C	BUD2	hom	Verified	1.51912656710496	0.0643653203241633	no	444	0.0577474654960586	225	NA	FT	CELL CYCLE|SIGNALING|CELL DIVISION|NUCLEOTIDE METABOLISM	PLASMA MEMBRANE		GTPase activating factor for Rsr1p/Bud1p; required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types; mutant deficient in mitotic spindle position checkpoint	bipolar cellular bud site selection|small GTPase mediated signal transduction|filamentous growth|cellular bud site selection|axial cellular bud site selection	GTPase activator activity|Ras GTPase activator activity	intracellular
YGR134W	YGR134W	CAF130	hom	Verified	1.51815129326789	0.0644881314617462	no	445	0.0568665460178638	285	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation	regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter	molecular_function	CCR4-NOT core complex
YKL038W	YKL038W	RGT1	hom	Verified	1.51805532094692	0.06450022658662	no	446	0.0925537700661338	364	NA	FT	TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM	NUCLEUS		Glucose-responsive transcription factor; regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor; RGT1 has a paralog, EDS1, that arose from the whole genome duplication	glucose transport|regulation of glucose import|negative regulation of transcription from RNA polymerase II promoter|glucose metabolic process|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription	nucleus
YDR147W	YDR147W	EKI1	hom	Verified	1.51671871764788	0.064668858228781	no	447	0.0583235748146711	236	NA	FT	LIPID METABOLISM			Ethanolamine kinase; primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; exhibits some choline kinase activity, thus contributing to phosphatidylcholine synthesis via the CDP-choline pathway; EKI1 has a paralog, CKI1, that arose from the whole genome duplication	phosphatidylethanolamine biosynthetic process|phosphatidylcholine biosynthetic process	ethanolamine kinase activity|choline kinase activity	cytoplasm
YML060W	YML060W	OGG1	hom	Verified	1.50845198544275	0.0657194432832299	no	448	0.0627084396520298	267	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION		Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA, contributes to UVA resistance	DNA repair|base-excision repair, AP site formation	oxidized purine nucleobase lesion DNA N-glycosylase activity	mitochondrion
YPL041C_p	YPL041C	YPL041C	hom	Uncharacterized	1.50353279754116	0.0663508529833507	no	449	0.0636361396754206	184	NA					Protein of unknown function involved in maintenance of proper telomere length	biological_process	molecular_function	cellular_component
YDR251W	YDR251W	PAM1	hom	Verified	1.50315749524926	0.0663992176719263	no	450	0.057401186516863	243	NA	FT	OXIDATION-REDUCTION PROCESS	SITE OF POLARIZED GROWTH		Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype	pseudohyphal growth	molecular_function	cellular bud|cellular bud neck
YGL254W	YGL254W	FZF1	hom	Verified	1.50216170271088	0.0665276763812722	no	451	0.072399626190627	242	NA	FT	TRANSCRIPTION FROM RNA POL II|ION HOMEOSTASIS|ION HOMEOSTASIS	NUCLEUS		Transcription factor involved in sulfite metabolism; sole identified regulatory target is SSU1; overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1, contains five zinc fingers; protein abundance increases in response to DNA replication stress	positive regulation of sulfite transport by positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YGR262C	YGR262C	BUD32	hom	Verified	1.50179835940299	0.0665745960801487	no	452	0.0823577224851166	259	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|LIPID METABOLISM|CELL DIVISION|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION	NUCLEUS|CHROMOSOME		Protein kinase, component of the EKC/KEOPS complex with Kae1p, Cgi121p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription	threonylcarbamoyladenosine metabolic process|protein phosphorylation|telomere maintenance|cellular bud site selection|positive regulation of transcription from RNA polymerase II promoter	protein serine/threonine kinase activity	EKC/KEOPS complex|nucleus|cytoplasm
YDR492W	YDR492W	IZH1	hom	Verified	1.49797581416047	0.0670697671827452	no	453	0.0632908277850683	302	NA	FT	LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc	response to zinc ion|cellular zinc ion homeostasis|cellular lipid metabolic process	metal ion binding	integral to membrane|endoplasmic reticulum|membrane
YBR056W	YBR056W	YBR056W	hom	Verified	1.49496854315832	0.0674613260023432	no	454	0.0598402198844393	307	NA	FT	CARBOHYDRATE METABOLISM			Putative glycoside hydrolase of the mitochondrial intermembrane space	biological_process	molecular_function	cytoplasm
YER152C	YER152C	YER152C	hom	Verified	1.49326937878991	0.0676833438428934	no	455	0.0558285215781268	224	NA	FT		NUCLEUS		Protein with 2-aminoadipate transaminase activity; shares amino acid similarity with the aminotransferases Aro8p and Aro9p; YER152C is not an essential gene	biological_process	2-aminoadipate transaminase activity	nucleus|cytoplasm
YOR331C_d	YOR331C	YOR331C	hom	Dubious	1.48764897110564	0.068421745760637	no	456	0.100605194799993	342	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene VMA4/YOR332W	Unknown	Unknown	Unknown
YKR016W	YKR016W	FCJ1	hom	Verified	1.48449164489586	0.068839269039637	no	457	0.063480729647813	279	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial inner membrane protein, ortholog of mammalian mitofilin; involved in import of intermembrane space (IMS) proteins, probably by positioning Mia40p relative to the TOM complex to receive incoming proteins; also has an essential role in the maintenance of crista junctions and inner membrane architecture, as a component of the mitochondrial inner membrane organizing system (MICOS, MitOS or MINOS), a scaffold-like structure on the IMS side of the inner membrane	cristae formation|protein import into mitochondrial intermembrane space	molecular_function	mitochondrion|mitochondrial inner membrane|mitochondrial crista|mitochondrial crista junction|integral to mitochondrial inner membrane
YIR036C_p	YIR036C	IRC24	hom	Uncharacterized	1.48259878531863	0.0690905200327076	no	458	0.0706807134860129	309	NA	FT	OXIDATION-REDUCTION PROCESS			Putative benzil reductase;(GFP)-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS; sequence similarity with short-chain dehydrogenase/reductases; null mutant has increased spontaneous Rad52p foci	biological_process	molecular_function	integral to membrane|cytoplasm
YDR234W	YDR234W	LYS4	hom	Verified	1.48246760935696	0.0691079579809999	no	459	0.0746520414116385	309	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway	lysine biosynthetic process via aminoadipic acid	homoaconitate hydratase activity	mitochondrion
YOR316C	YOR316C	COT1	hom	Verified	1.47922720722115	0.0695398001545383	no	460	0.0816454060033357	334	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium; protein abundance increases in response to DNA replication stress; COT1 has a paralog, ZRC1, that arose from the whole genome duplication	cellular zinc ion homeostasis|cobalt ion transport|zinc ion transport	cobalt ion transmembrane transporter activity|zinc ion transmembrane transporter activity|inorganic cation transmembrane transporter activity	mitochondrion|integral to membrane|fungal-type vacuole
YDL109C_p	YDL109C	YDL109C	hom	Uncharacterized	1.47877835215682	0.0695997816979234	no	461	0.075931168082184	372	NA	FT	LIPID METABOLISM			Putative lipase; involved in lipid metabolism; not an essential gene; YDL109C has a paralog, ROG1, that arose from the whole genome duplication	cellular lipid metabolic process	molecular_function	cellular_component
YDR480W	YDR480W	DIG2	hom	Verified	1.47473983444003	0.0701412511012352	no	462	0.0622043429508664	275	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p	negative regulation of transcription from RNA polymerase II promoter by pheromones|Unknown	transcription factor binding	nucleus
YBL042C	YBL042C	FUI1	hom	Verified	1.47433024350312	0.0701963480110411	no	463	0.089784772077041	465	NA	FF|FT		PLASMA MEMBRANE		High affinity uridine permease, localizes to the plasma membrane; also mediates low but significant transport of the cytotoxic nucleoside analog 5-fluorouridine; not involved in uracil transport; relative distribution to the vacuole increases upon DNA replication stress	uridine transport|transmembrane transport	uridine transmembrane transporter activity	integral to membrane|plasma membrane
YLR109W	YLR109W	AHP1	hom	Verified	1.47222476293881	0.07048009626034	no	464	0.0650623231841663	304	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS			Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p	cellular response to oxidative stress|response to metal ion|cell redox homeostasis	thioredoxin peroxidase activity	plasma membrane|cytoplasm
YDL112W	YDL112W	TRM3	hom	Verified	1.47147293907015	0.0705816302944265	no	465	0.0798802963080614	300	NA	FT	RNA PROCESSING			2'-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs	tRNA methylation	tRNA (guanine) methyltransferase activity	cytoplasm
YGL198W	YGL198W	YIP4	hom	Verified	1.47146950649808	0.0705820941219743	no	466	0.0823477066690646	320	NA	FT		ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport	biological_process	Rab GTPase binding	integral to membrane|Golgi apparatus
YPL072W	YPL072W	UBP16	hom	Verified	1.47132351032821	0.0706018240764559	no	467	0.0576056841986647	267	NA	FT	PROTEOLYSIS	MITOCHONDRION		Deubiquitinating enzyme anchored to the outer mitochondrial membrane, probably not important for general mitochondrial functioning, but may perform a more specialized function at mitochondria	protein deubiquitination	ubiquitin-specific protease activity	mitochondrial outer membrane|cytoplasm
YLR211C_p	YLR211C	YLR211C	hom	Uncharacterized	1.47035439628301	0.0707328978337722	no	468	0.0575610022488368	240	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR211C is not an essential gene; ORF contains an intron	biological_process	molecular_function	cytoplasm
YHR171W	YHR171W	ATG7	hom	Verified	1.46785528589006	0.0710717681058399	no	469	0.110301195209582	399	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS	MITOCHONDRION		Autophagy-related protein and dual specificity member of the E1 family of ubiquitin-activating enzymes; mediates the conjugation of Atg12p with Atg5p and Atg8p with phosphatidylethanolamine, required steps in autophagosome formation	C-terminal protein lipidation|protein modification by small protein conjugation|piecemeal microautophagy of nucleus|mitochondrion degradation|macroautophagy|CVT pathway	APG8 activating enzyme activity|APG12 activating enzyme activity	cytosol|mitochondrion|membrane|pre-autophagosomal structure
YLR419W_p	YLR419W	YLR419W	hom	Uncharacterized	1.46562186152143	0.0713756660582652	no	470	0.0660777888171538	270	NA	FT		MITOCHONDRION		Putative helicase with limited sequence similarity to human Rb protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR419W is not an essential gene	biological_process	molecular_function	mitochondrion|cytoplasm
YCR020C-A	YCR020C-A	MAK31	hom	Verified	1.46514288422791	0.0714409693158021	no	471	0.0611777012139643	291	NA					Non-catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus; member of the Sm protein family	N-terminal protein amino acid acetylation	peptide alpha-N-acetyltransferase activity	NatC complex
YNL130C	YNL130C	CPT1	hom	Verified	1.46310544583362	0.071719263977918	no	472	0.0562163593001079	249	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS		Cholinephosphotransferase; required for phosphatidylcholine biosynthesis and for inositol-dependent regulation of EPT1 transcription; CPT1 has a paralog, EPT1, that arose from the whole genome duplication	CDP-choline pathway	diacylglycerol cholinephosphotransferase activity	mitochondrial outer membrane|integral to membrane|Golgi apparatus
YDR250C_d	YDR250C	YDR250C	hom	Dubious	1.46108369391313	0.0719962372738123	no	473	0.0730967673629024	274	NA					Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR125W_p	YLR125W	YLR125W	hom	Uncharacterized	1.4555987549582	0.0727517862146054	no	474	0.071500226646726	324	NA					Putative protein of unknown function; mutant has decreased Ty3 transposition; YLR125W is not an essential gene	biological_process	molecular_function	cellular_component
YLL010C	YLL010C	PSR1	hom	Verified	1.45305073364461	0.073104834177166	no	475	0.0787310620796477	348	NA	FT		PLASMA MEMBRANE		Plasma membrane associated protein phosphatase involved in the general stress response; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p	response to stress	phosphoprotein phosphatase activity	plasma membrane
YHR001W	YHR001W	OSH7	hom	Verified	1.45030587249662	0.073486621090962	no	476	0.0516463597602089	215	NA	FT	VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	ENDOPLASMIC RETICULUM		Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability	maintenance of cell polarity|endocytosis|exocytosis|sterol transport|sterol metabolic process|late endosome to vacuole transport	lipid binding|oxysterol binding	integral to membrane|cortical endoplasmic reticulum|cytoplasm
YOL154W	YOL154W	ZPS1	hom	Verified	1.45025802320108	0.0734932900181016	no	477	0.0512593229132181	218	NA					Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH	biological_process	molecular_function	fungal-type cell wall|fungal-type vacuole
YPR153W	YPR153W	YPR153W	hom	Verified	1.44497774947121	0.0742320678078615	no	478	0.0596036630317577	245	NA					Putative protein of unknown function	biological_process	molecular_function	integral to membrane
YGR088W	YGR088W	CTT1	hom	Verified	1.44281205163084	0.0745367116469276	no	479	0.0419985602617054	159	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS			Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide	response to reactive oxygen species	catalase activity	cytoplasm
YNL115C_p	YNL115C	YNL115C	hom	Uncharacterized	1.44242086597866	0.0745918404659748	no	480	0.0633585990770855	290	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YDL110C	YDL110C	TMA17	hom	Verified	1.43702045364582	0.0753560909307092	no	481	0.0569235070254571	232	NA	FT		NUCLEUS		Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion	biological_process	molecular_function	ribosome|nucleus|cytoplasm
YOR043W	YOR043W	WHI2	hom	Verified	1.43306455592424	0.0759196947184823	no	482	0.0595334801011944	260	NA	FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION			Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression	response to salt stress|mitochondrion degradation|actin filament organization|endocytosis|response to heat|regulation of growth|response to stress	phosphatase activator activity	cellular_component
YOR371C	YOR371C	GPB1	hom	Verified	1.43194884318025	0.0760792311825881	no	483	0.0684393156727418	296	NA	FT	SIGNALING|PROTEOLYSIS	PLASMA MEMBRANE		Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; promotes ubiquitin-dependent proteolysis of Ira2p; regulated by G-alpha protein Gpa2p; GPB1 has a paralog, GPB2, that arose from the whole genome duplication	positive regulation of Ras protein signal transduction|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of phosphorylation|signal transduction|glucose mediated signaling pathway|pseudohyphal growth|invasive growth in response to glucose limitation|negative regulation of Ras protein signal transduction|protein polyubiquitination	cAMP-dependent protein kinase inhibitor activity|signal transducer activity|GTPase activating protein binding	plasma membrane|cytoplasm
YDR522C	YDR522C	SPS2	hom	Verified	1.42969429561909	0.0764023890962718	no	484	0.062818920436635	310	NA	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS	PLASMA MEMBRANE		Protein expressed during sporulation; SPS2 has a paralog, SPS22, that arose from the whole genome duplication; redundant with Sps22p for organization of the beta-glucan layer of the spore wall; S. pombe ortholog is a spore wall component	ascospore wall assembly|ascospore formation	molecular_function	fungal-type cell wall|plasma membrane
YBL044W_p	YBL044W	YBL044W	hom	Uncharacterized	1.42930247795546	0.0764586570542073	no	485	0.0750257731804642	277	NA					Putative protein of unknown function; YBL044W is not an essential protein	biological_process	molecular_function	cellular_component
YIR033W	YIR033W	MGA2	hom	Verified	1.42679671798065	0.0768192487430037	no	486	0.0646414118632754	241	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|GENE SILENCING	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia|cellular response to cold|positive regulation of unsaturated fatty acid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|mRNA stabilization|positive regulation of transcription from RNA polymerase II promoter in response to cobalt ion|positive regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette	molecular_function	integral to endoplasmic reticulum membrane|nucleus
YOL128C	YOL128C	YGK3	hom	Verified	1.42677849118545	0.0768218764006161	no	487	0.0825224702702929	317	NA	FT	PROTEOLYSIS|PROTEIN PHOSPHORYLATION			Protein kinase related to mammalian glycogen synthase kinases of the GSK-3 family; GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradation	proteolysis|protein phosphorylation|response to stress	protein serine/threonine kinase activity|protein kinase activity	cellular_component
YDL137W	YDL137W	ARF2	hom	Verified	1.4266470916182	0.076840821581374	no	488	0.0821422161679535	345	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|RESPONSE TO NUTRIENT LEVELS	GOLGI APPARATUS		ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; ARF2 has a paralog, ARF1, that arose from the whole genome duplication	ER to Golgi vesicle-mediated transport|macroautophagy|intra-Golgi vesicle-mediated transport	GTPase activity	cytosol|Golgi-associated vesicle
YGR106C	YGR106C	VOA1	hom	Verified	1.42644729692657	0.0768696347727806	no	489	0.135720164140337	521	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Endoplasmic reticulum protein that functions, together with other assembly factors, in assembly of the V0 sector of the vacuolar ATPase (V-ATPase); null mutation enhances the V-ATPase deficiency of a vma21 mutant impaired in ER retrieval	protein complex assembly	molecular_function	fungal-type vacuole membrane|endoplasmic reticulum membrane
YFR032C_p	YFR032C	RRT5	hom	Uncharacterized	1.42311914346649	0.0773508098754016	no	490	0.0731714189036541	346	NA					Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; expressed at high levels during sporulation	biological_process	molecular_function	cellular_component
YOR028C	YOR028C	CIN5	hom	Verified	1.42248470595344	0.0774427941492131	no	491	0.0597158036089079	232	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Basic leucine zipper (bZIP) transcription factor of the yAP-1 family; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; mediates pleiotropic drug resistance and salt tolerance; nuclearly localized under oxidative stress and sequestered in the cytoplasm by Lot6p under reducing conditions; CIN5 has a paralog, YAP6, that arose from the whole genome duplication	hyperosmotic salinity response|response to drug|hyperosmotic response|regulation of transcription from RNA polymerase II promoter	repressing transcription factor binding|sequence-specific DNA binding	nucleus|cytoplasm
YMR311C	YMR311C	GLC8	hom	Verified	1.42229884672904	0.0774697567787127	no	492	0.0868879461537771	387	NA	FT	SIGNALING|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|CHROMOSOME SEGREGATION	NUCLEUS		Regulatory subunit of protein phosphatase 1 (Glc7p); involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2; protein abundance increases in response to DNA replication stress	chromosome segregation|glycogen biosynthetic process	enzyme activator activity	nucleus|cytoplasm
YPR005C	YPR005C	HAL1	hom	Verified	1.42032750996319	0.0777561779084741	no	493	0.0873513999381303	358	NA	FT	TRANSCRIPTION FROM RNA POL II			Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p	response to salt stress|positive regulation of transcription from RNA polymerase II promoter	molecular_function	cytoplasm
YEL012W	YEL012W	UBC8	hom	Verified	1.41786256887696	0.078115446237564	no	494	0.0766902933932847	317	NA	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS			Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro	negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein polyubiquitination|protein monoubiquitination	ubiquitin-protein ligase activity	cytoplasm
YGR079W_p	YGR079W	YGR079W	hom	Uncharacterized	1.414839789163	0.0785577375048351	no	495	0.0702834544321899	313	NA					Putative protein of unknown function; YGR079W is not an essential gene	biological_process	molecular_function	cellular_component
YDR262W_p	YDR262W	YDR262W	hom	Uncharacterized	1.41300809826334	0.0788266714937939	no	496	0.0537277201726123	243	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole and is induced in response to the DNA-damaging agent MMS; gene expression increases in response to Zymoliase treatment	biological_process	molecular_function	fungal-type vacuole
YOR316C-A_p	YOR316C-A	YOR316C-A	hom	Uncharacterized	1.41090312167452	0.0791365907973017	no	497	0.0608232065712574	247	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YAL026C	YAL026C	DRS2	hom	Verified	1.40804436725106	0.0795589664022429	no	498	0.0992798145516728	436	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RIBOSOME BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS	GOLGI APPARATUS		Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation and endocytosis; mutations in human homolog ATP8B1 result in liver disease	intracellular protein transport|post-Golgi vesicle-mediated transport|phospholipid translocation|endocytosis|ribosomal small subunit assembly	phospholipid-translocating ATPase activity	trans-Golgi network|integral to membrane
YPR160W	YPR160W	GPH1	hom	Verified	1.40750714156734	0.079638530540356	no	499	0.0577337113951446	244	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway	glycogen catabolic process	glycogen phosphorylase activity	cytoplasm
YNL195C_p	YNL195C	YNL195C	hom	Uncharacterized	1.40679105683574	0.0797446776219149	no	500	0.0968472220148664	413	NA	FT		MITOCHONDRION		Putative protein of unknown function; shares a promoter with YNL194C; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YLL049W	YLL049W	LDB18	hom	Verified	1.40502095997272	0.0800075228285563	no	501	0.0649302053819526	289	NA	FT	CELL CYCLE|CYTOSKELETON ORGANIZATION	CYTOSKELETON		Component of the dynactin complex, which is required for dynein activity; null mutant exhibits defects in nuclear migration and spindle orientation and has reduced affinity for alcian blue dye; has homology to mammalian dynactin subunit p24	establishment of mitotic spindle orientation	molecular_function	dynactin complex|cell cortex|spindle pole body|astral microtubule
YMR056C	YMR056C	AAC1	hom	Verified	1.40474858679401	0.0800480261492462	no	502	0.0711802439182864	332	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator; relocalizes from mitochondrion to cytoplasm upon DNA replication stress	heme biosynthetic process|mitochondrial transport|heme transport|aerobic respiration	ATP:ADP antiporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YCR073C	YCR073C	SSK22	hom	Verified	1.40316997651814	0.0802830791213826	no	503	0.0691545997677748	255	NA	FT	SIGNALING|PROTEIN PHOSPHORYLATION			MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; functionally redundant with, and homologous to, Ssk2p; interacts with and is activated by Ssk1p; phosphorylates Pbs2p	MAPK cascade involved in osmosensory signaling pathway|protein phosphorylation	protein kinase activity|MAP kinase kinase kinase activity	cellular_component
YDR383C	YDR383C	NKP1	hom	Verified	1.40146632387114	0.0805373355520869	no	504	0.0858047465314865	331	NA	FT	CELL CYCLE|CELL DIVISION	NUCLEUS|CHROMOSOME	KINETOCHORE	Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein fta4	biological_process	molecular_function	kinetochore
YIL105C	YIL105C	SLM1	hom	Verified	1.40122827365888	0.0805729110083942	no	505	0.0756515823689984	296	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|SIGNALING|CYTOSKELETON ORGANIZATION	MITOCHONDRION|PLASMA MEMBRANE		Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; protein abundance increases in response to DNA replication stress; SLM1 has a paralog, SLM2, that arose from the whole genome duplication	eisosome assembly|TOR signaling cascade|regulation of cell growth|actin filament bundle assembly|endosomal transport|establishment or maintenance of actin cytoskeleton polarity|actin cytoskeleton organization	phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol binding|sphingolipid binding	eisosome|mitochondrion|membrane raft|plasma membrane|cytoplasm
YDR029W_d	YDR029W	YDR029W	hom	Dubious	1.4002427254142	0.0807203227472154	no	506	0.0614390267553823	243	NA					Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YBR028C	YBR028C	YPK3	hom	Verified	1.39885985273133	0.080927506875516	no	507	0.104541793662838	367	NA	FT	PROTEIN PHOSPHORYLATION			An AGC kinase phosphorylated by cAMP-dependent protein kinase (PKA) in a TORC1-dependent manner	biological_process	protein kinase activity	cytoplasm
YGL050W	YGL050W	TYW3	hom	Verified	1.39828753282249	0.0810133700821219	no	508	0.078534431236853	293	NA	FT	RNA PROCESSING			tRNA methyltransferase required for synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions	tRNA methylation|wybutosine biosynthetic process	tRNA methyltransferase activity	cellular_component
YDR239C	YDR239C	YDR239C	hom	Verified	1.39732199260777	0.0811583826159984	no	509	0.0828113331782964	306	NA					Protein of unknown function that may interact with ribosomes, based on co-purification experiments	biological_process	molecular_function	ribosome|cytoplasm
YOR192C	YOR192C	THI72	hom	Verified	1.39719591773426	0.0811773319945748	no	510	0.0891110973316772	368	NA					Transporter of thiamine or related compound; shares sequence similarity with Thi7p	thiamine transport	transporter activity	integral to membrane|membrane
YLR248W	YLR248W	RCK2	hom	Verified	1.39715244265397	0.0811838671852818	no	511	0.0859978367053013	359	NA	FT	CELL CYCLE|SIGNALING|PROTEIN PHOSPHORYLATION|RESPONSE TO OXIDATIVE STRESS			Protein kinase involved in response to oxidative and osmotic stress; identified as suppressor of S. pombe cell cycle checkpoint mutations; similar to CaM (calmodulin) kinases; RCK2 has a paralog, RCK1, that arose from the whole genome duplication	cellular response to oxidative stress|protein phosphorylation|osmosensory signaling pathway|regulation of meiosis	protein serine/threonine kinase activity|protein kinase activity	cytoplasm
YBR200W-A_p	YBR200W-A	YBR200W-A	hom	Uncharacterized	1.39413158685625	0.0816389361405305	no	512	0.100229793455833	406	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YLR408C_p	YLR408C	BLS1	hom	Uncharacterized	1.38920857089021	0.0823846680996013	no	513	0.0662674089047208	260	NA					Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene	biological_process	molecular_function	endosome|BLOC-1 complex
YDL052C	YDL052C	SLC1	hom	Verified	1.38563921705111	0.0829285484551184	no	514	0.10370745647049	391	NA	FT	LIPID METABOLISM			1-acyl-sn-glycerol-3-phosphate acyltransferase, catalyzes the acylation of lysophosphatidic acid to form phosphatidic acid, a key intermediate in lipid metabolism; enzymatic activity detected in lipid particles and microsomes	glycerophospholipid biosynthetic process	1-acylglycerol-3-phosphate O-acyltransferase activity	lipid particle
YDR246W-A_p	YDR246W-A	YDR246W-A	hom	Uncharacterized	1.38460912996796	0.0830860091142528	no	515	0.070269806619042	328	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YDL189W	YDL189W	RBS1	hom	Verified	1.38362172068666	0.0832371569457145	no	516	0.0731511271333346	293	NA	FT	CARBOHYDRATE METABOLISM			Protein of unknown function, identified as a high copy suppressor of psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization; proposed to bind single-stranded nucleic acids via its R3H domain	galactose metabolic process	molecular_function	cytoplasm
YBR139W	YBR139W	YBR139W	hom	Verified	1.38315643909452	0.0833084516177526	no	517	0.0891295555502825	382	NA	FT	PROTEOLYSIS			Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner	phytochelatin biosynthetic process	serine hydrolase activity|serine-type carboxypeptidase activity	fungal-type vacuole
YOL158C	YOL158C	ENB1	hom	Verified	1.38073055194056	0.0836809118788937	no	518	0.0773232036052034	262	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Endosomal ferric enterobactin transporter, expressed under conditions of iron deprivation; member of the major facilitator superfamily; expression is regulated by Rcs1p and affected by chloroquine treatment	ferric-enterobactin transport	ferric-enterobactin transmembrane transporter activity	integral to membrane|cellular bud membrane|plasma membrane
YKL163W	YKL163W	PIR3	hom	Verified	1.38028701153091	0.083749146231294	no	519	0.0685497528735712	279	NA	FT	CELL WALL ORG/BIOGENESIS			O-glycosylated covalently-bound cell wall protein; required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway; PIR3 has a paralog, HSP150, that arose from the whole genome duplication	fungal-type cell wall organization	structural constituent of cell wall	fungal-type cell wall
YBL037W	YBL037W	APL3	hom	Verified	1.38008624791592	0.0837800454862777	no	520	0.0803456187535482	312	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|PLASMA MEMBRANE		Alpha-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport	vesicle-mediated transport	molecular_function	AP-2 adaptor complex
YNL072W	YNL072W	RNH201	hom	Verified	1.37730746978219	0.0842086033780112	no	521	0.177823996742192	615	NA	FT		NUCLEUS		Ribonuclease H2 catalytic subunit, removes RNA primers during Okazaki fragment synthesis and errant ribonucleotides misincorporated during DNA replication; homolog of RNAse HI; related to human AGS4 which causes Aicardi-Goutieres syndrome	DNA replication, removal of RNA primer	ribonuclease H activity	ribonuclease H2 complex|nucleus
YEL027W	YEL027W	VMA3	hom	Verified	1.37542120559772	0.0845004492228816	no	522	0.10075347993605	386	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT			Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis	cellular copper ion homeostasis|cellular iron ion homeostasis|endocytosis|vacuole organization|proton transport|vacuolar acidification|protein targeting to vacuole	hydrogen ion transmembrane transporter activity	vacuolar proton-transporting V-type ATPase, V0 domain|integral to membrane
YDL236W	YDL236W	PHO13	hom	Verified	1.37303980779788	0.0848699858416689	no	523	0.0944471670890914	340	NA	FT		NUCLEUS		Alkaline phosphatase specific for p-nitrophenyl phosphate; also has protein phosphatase activity	protein dephosphorylation	4-nitrophenylphosphatase activity|phosphoprotein phosphatase activity|alkaline phosphatase activity	nucleus|cytoplasm
YDR461W	YDR461W	MFA1	hom	Verified	1.37030987276536	0.0852950962404689	no	524	0.0876658836544787	324	NA	FT	SIGNALING	PLASMA MEMBRANE		Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA2	pheromone-dependent signal transduction involved in conjugation with cellular fusion	mating pheromone activity	extracellular region
YMR264W	YMR264W	CUE1	hom	Verified	1.36737817371857	0.0857534000084414	no	525	0.105583206637253	460	NA	FF|FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION	UBIQUITIN LIGASE COMPLEX	Ubiquitin-binding protein; endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination; CUE1 has a paralog, CUE4, that arose from the whole genome duplication	ER-associated protein catabolic process|establishment of protein localization to endoplasmic reticulum membrane	ubiquitin-protein ligase activator activity	Doa10p ubiquitin ligase complex|mitochondrion|integral to endoplasmic reticulum membrane
YOL067C	YOL067C	RTG1	hom	Verified	1.36707690764534	0.0858006002841841	no	526	0.111902619111473	434	NA	FT	TRANSCRIPTION FROM RNA POL II|SIGNALING	NUCLEUS		Transcription factor (bHLH) involved in interorganelle communication between mitochondria, peroxisomes, and nucleus	cellular response to oleic acid|positive regulation of transcription from RNA polymerase II promoter|mitochondria-nucleus signaling pathway	sequence-specific DNA binding RNA polymerase II transcription factor activity	nucleus|cytoplasm
YKL090W	YKL090W	CUE2	hom	Verified	1.36589562165527	0.0859858635936575	no	527	0.0788390357930053	339	NA					Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination	biological_process	ubiquitin binding	cellular_component
YDR043C	YDR043C	NRG1	hom	Verified	1.3645703070242	0.0861940713009529	no	528	0.0677009699994539	254	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Transcriptional repressor; recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response; NRG1 has a paralog, NRG2, that arose from the whole genome duplication	negative regulation of transcription from RNA polymerase II promoter by glucose|cellular hyperosmotic salinity response|biofilm formation|negative regulation of transcription from RNA polymerase II promoter|pseudohyphal growth|Unknown	RNA polymerase II repressing transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription	nucleus
YPL277C_p	YPL277C	YPL277C	hom	Uncharacterized	1.3639268696877	0.0862952915695468	no	529	0.0710770269925423	318	NA					Putative protein of unknown function; localized to the membranes; gene expression regulated by copper levels	biological_process	molecular_function	membrane
YLR133W	YLR133W	CKI1	hom	Verified	1.36329714939853	0.0863944400332389	no	530	0.126946262710199	429	NA	FT	LIPID METABOLISM			Choline kinase; catalyzes the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; CKI1 has a paralog, EKI1, that arose from the whole genome duplication	phosphatidylethanolamine biosynthetic process|phosphatidylcholine biosynthetic process	ethanolamine kinase activity|choline kinase activity	cytoplasm
YLR057W	YLR057W	MNL2	hom	Verified	1.36072785041941	0.0867998549574742	no	531	0.0992030428850137	379	NA	FT	PROTEOLYSIS	ENDOPLASMIC RETICULUM		Putative mannosidase involved in ER-associated protein degradation; localizes to the endoplasmic reticulum; sequence similarity with seven-hairpin glycosidase (GH47) family members, such as Mns1p and Mnl1p, that hydrolyze 1,2-linked alpha-D-mannose residues; non-essential gene	ER-associated protein catabolic process	molecular_function	endoplasmic reticulum
YDR254W	YDR254W	CHL4	hom	Verified	1.36039811656551	0.0868519870886738	no	532	0.0839043302191283	303	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME	KINETOCHORE	Outer kinetochore protein required for chromosome stability; involved in new kinetochore assembly and sister chromatid cohesion; peripheral component of the Ctf19 kinetochore complex that interacts with Ctf19p, Ctf3p, Iml3p and Mif2p; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-N and fission yeast mis15	kinetochore assembly|chromosome segregation|establishment of meiotic sister chromatid cohesion|protein localization to chromosome, centromeric region|maintenance of meiotic sister chromatid cohesion|establishment of mitotic sister chromatid cohesion	structural molecule activity	condensed nuclear chromosome outer kinetochore
YDR446W	YDR446W	ECM11	hom	Verified	1.35854981831991	0.0871446429783734	no	533	0.0525317693162828	238	NA	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS	NUCLEUS		Non-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure	fungal-type cell wall organization|reciprocal meiotic recombination	molecular_function	nucleus
YLR181C	YLR181C	VTA1	hom	Verified	1.35787048353303	0.0872523923762453	no	534	0.0786186318604902	342	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|VACUOLAR TRANSPORT			Multivesicular body (MVB) protein involved in endosomal protein sorting; regulates Vps4p activity by promoting its oligomerization; has an N-terminal Vps60- and Did2- binding domain, a linker region, and a C-terminal Vps4p binding domain	late endosome to vacuole transport via multivesicular body sorting pathway|positive regulation of protein oligomerization|late endosome to vacuole transport	ATPase activator activity	endosome|endosome membrane|multivesicular body
YGR070W	YGR070W	ROM1	hom	Verified	1.35598007729836	0.0875527535033337	no	535	0.0971143068917609	403	NA	FT	SIGNALING|NUCLEOTIDE METABOLISM			GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP	small GTPase mediated signal transduction|activation of Rho GTPase activity	Rho guanyl-nucleotide exchange factor activity	intracellular
YIR043C	YIR043C	YIR043C	hom	pseudogene	1.35479842438931	0.0877408943774301	no	536	0.0886491494311597	303	NA					Possible pseudogene in strain S288C; YIR043C and the adjacent ORF, YIR044C, together may encode a non-functional member of the conserved, often subtelomerically-encoded Cos protein family	biological_process	molecular_function	cellular_component
YOL018C	YOL018C	TLG2	hom	Verified	1.35383356795695	0.0878947408087901	no	537	0.215001362133234	748	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	GOLGI APPARATUS		Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16)	inositolphosphoceramide metabolic process|Golgi to vacuole transport|endocytosis|mannosyl-inositol phosphorylceramide metabolic process|protein exit from endoplasmic reticulum|vesicle fusion|CVT pathway	SNAP receptor activity	SNARE complex|trans-Golgi network|integral to endosome membrane
YDR218C	YDR218C	SPR28	hom	Verified	1.3523045105615	0.0881389610334598	no	538	0.0676071748457414	264	NA	FT	CELL CYCLE|CELL DIVISION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; meiotic septin expressed at high levels during meiotic divisions and ascospore formation	sexual sporulation resulting in formation of a cellular spore	structural molecule activity	spindle microtubule|meiotic spindle|septin complex|prospore membrane|ascospore wall
YNL142W	YNL142W	MEP2	hom	Verified	1.34965324120685	0.0885636187845612	no	539	0.0803169960920814	286	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation	nitrogen utilization|ammonium transport|pseudohyphal growth	ammonium transmembrane transporter activity	integral to membrane|plasma membrane
YDR123C	YDR123C	INO2	hom	Verified	1.34900222668506	0.0886681254405807	no	540	0.0982907037515192	390	NA	FT	TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM	NUCLEUS		Component of the heteromeric Ino2p/Ino4p basic helix-loop-helix transcription activator that binds inositol/choline-responsive elements (ICREs), required for derepression of phospholipid biosynthetic genes in response to inositol depletion	phospholipid biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YCL002C_p	YCL002C	YCL002C	hom	Uncharacterized	1.34837728503498	0.0887685330240383	no	541	0.0881726414903663	366	NA					Putative protein of unknown function; YCL002C is not an essential gene	biological_process	molecular_function	integral to membrane
YER121W_p	YER121W	YER121W	hom	Uncharacterized	1.34760772231409	0.0888922927572478	no	542	0.106477126860391	378	NA					Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy	biological_process	molecular_function	cellular_component
YCR049C_d	YCR049C	YCR049C	hom	Dubious	1.34577453463537	0.0891876201994637	no	543	0.110856816485256	411	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YAL047C	YAL047C	SPC72	hom	Verified	1.34303528436927	0.0896302744423974	no	544	0.094841628955798	361	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	NUCLEUS|CYTOSKELETON		Component of the cytoplasmic Tub4p (gamma-tubulin) complex, binds spindle pole bodies and links them to microtubules; has roles in astral microtubule formation and stabilization	microtubule nucleation|nuclear migration along microtubule|mitotic cell cycle spindle orientation checkpoint|mitotic spindle elongation|mitotic sister chromatid segregation	structural constituent of cytoskeleton	outer plaque of spindle pole body
YOL150C_d	YOL150C	YOL150C	hom	Dubious	1.34147191728065	0.0898836407628321	no	545	0.0786734692308078	297	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPR167C	YPR167C	MET16	hom	Verified	1.34102260247215	0.0899565571309396	no	546	0.0854463882093064	336	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS			3'-phosphoadenylsulfate reductase, reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism	sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)|sulfur amino acid metabolic process	phosphoadenylyl-sulfate reductase (thioredoxin) activity	cytoplasm
YMR021C	YMR021C	MAC1	hom	Verified	1.33918374854041	0.0902554308415974	no	547	0.206831246299766	739	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|ION HOMEOSTASIS|ION HOMEOSTASIS	NUCLEUS		Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport	cellular copper ion homeostasis|positive regulation of protein catabolic process|positive regulation of transcription from RNA polymerase II promoter	core promoter proximal region DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YDR066C	YDR066C	RTR2	hom	Verified	1.33662309388918	0.0906728484285531	no	548	0.0920866076472518	358	NA	FT		NUCLEUS		Protein of unknown function; exhibits genetic interactions with Rtr1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDR066C is not an essential gene; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; RTR2 has a paralog, RTR1, that arose from the whole genome duplication	biological_process	molecular_function	cytoplasm
YGL223C	YGL223C	COG1	hom	Verified	1.33396677302601	0.0911073731014039	no	549	0.143484072182354	475	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments	retrograde transport, vesicle recycling within Golgi|intra-Golgi vesicle-mediated transport|CVT pathway	molecular_function	Golgi transport complex
YOR309C_d	YOR309C	YOR309C	hom	Dubious	1.3332342822864	0.0912274661682399	no	550	0.114421449510242	405	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58	Unknown	Unknown	Unknown
YLR047C	YLR047C	FRE8	hom	Verified	1.33320985435634	0.091231473189259	no	551	0.110419842468622	425	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY			Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p	cellular metal ion homeostasis	oxidoreductase activity, oxidizing metal ions	integral to membrane|membrane
YMR081C	YMR081C	ISF1	hom	Verified	1.3322848626992	0.0913832996938559	no	552	0.076858072960149	334	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY			Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant	aerobic respiration	molecular_function	cellular_component
YDR380W	YDR380W	ARO10	hom	Verified	1.3318294686214	0.0914581160462773	no	553	0.0737287945554829	283	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Phenylpyruvate decarboxylase, catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde, which is the first specific step in the Ehrlich pathway	L-phenylalanine catabolic process|methionine catabolic process to 3-methylthiopropanol|tryptophan catabolic process|branched-chain amino acid catabolic process to alcohol via Ehrlich pathway|aromatic amino acid family catabolic process to alcohol via Ehrlich pathway|leucine catabolic process	pyruvate decarboxylase activity|carboxy-lyase activity|phenylpyruvate decarboxylase activity	cytoplasm
YGR149W_p	YGR149W	YGR149W	hom	Uncharacterized	1.32970122934136	0.0918083648231418	no	554	0.0709231469994537	269	NA					Putative protein of unknown function; predicted to be an integal membrane protein	biological_process	molecular_function	integral to membrane
YOR266W	YOR266W	PNT1	hom	Verified	1.32901676324637	0.091921219723079	no	555	0.0654351986902404	238	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial integral inner membrane protein involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p; deletion mutant sensitive to the anti-Pneumocystis carinii drug pentamidine	protein insertion into mitochondrial membrane from inner side	molecular_function	mitochondrion|integral to mitochondrial inner membrane
YIR039C	YIR039C	YPS6	hom	Verified	1.32899117979177	0.0919254399188859	no	556	0.109399119344766	441	NA	FT	CELL WALL ORG/BIOGENESIS|PROTEOLYSIS	PLASMA MEMBRANE		Putative GPI-anchored aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance	fungal-type cell wall organization	aspartic-type endopeptidase activity	fungal-type cell wall
YJR070C	YJR070C	LIA1	hom	Verified	1.32816708384841	0.0920614579138551	no	557	0.100300737617823	378	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CYTOSKELETON ORGANIZATION	NUCLEUS		Deoxyhypusine hydroxylase; HEAT-repeat containing metalloenzyme that catalyzes hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning; protein abundance increases in response to DNA replication stress	microtubule cytoskeleton organization|peptidyl-lysine modification to hypusine	deoxyhypusine monooxygenase activity	nucleus|cytoplasm
YGL032C	YGL032C	AGA2	hom	Verified	1.32777368617938	0.0921264411792143	no	558	0.0851975320001688	370	NA					Adhesion subunit of a-agglutinin of a-cells, C-terminal sequence acts as a ligand for alpha-agglutinin (Sag1p) during agglutination, modified with O-linked oligomannosyl chains, linked to anchorage subunit Aga1p via two disulfide bonds	agglutination involved in conjugation with cellular fusion	cell adhesion molecule binding	fungal-type cell wall
YIL085C	YIL085C	KTR7	hom	Verified	1.32595039822129	0.0924280638655333	no	559	0.0848853349946257	355	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	GOLGI APPARATUS		Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR7 has a paralog, KTR5, that arose from the whole genome duplication	fungal-type cell wall organization|protein N-linked glycosylation	mannosyltransferase activity	Golgi apparatus
YFR041C	YFR041C	ERJ5	hom	Verified	1.32323854321912	0.0928780310354794	no	560	0.0814569872239376	365	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Type I membrane protein with a J domain is required to preserve the folding capacity of the endoplasmic reticulum; loss of the non-essential ERJ5 gene leads to a constitutively induced unfolded protein response	protein folding	molecular_function	endoplasmic reticulum
YOR107W	YOR107W	RGS2	hom	Verified	1.32135168427437	0.0931920640698637	no	561	0.105399091168913	420	NA	FT	SIGNALING	NUCLEUS|PLASMA MEMBRANE		Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	GTPase activator activity	nucleus|cytoplasm
YHR193C	YHR193C	EGD2	hom	Verified	1.31886965662848	0.0936063459742516	no	562	0.0924479596715408	368	NA	FT	PROTEIN LOCALIZATION	NUCLEUS		Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes	'de novo' cotranslational protein folding	unfolded protein binding|phosphatidic acid binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4-phosphate binding	nascent polypeptide-associated complex
YBR185C	YBR185C	MBA1	hom	Verified	1.31525676657283	0.0942118113722229	no	563	0.089854697231052	354	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Membrane-associated mitochondrial ribosome receptor; forms a complex with Mdm38p that may facilitate recruitment of mRNA-specific translational activators to ribosomes; possible role in protein export from the matrix to inner membrane	protein insertion into mitochondrial membrane from inner side|mitochondrial respiratory chain complex III biogenesis|inner mitochondrial membrane organization|positive regulation of mitochondrial translation|mitochondrial respiratory chain complex IV biogenesis	ribosome binding	mitochondrion|mitochondrial inner membrane
YLR108C	YLR108C	YLR108C	hom	Verified	1.31380339657854	0.0944561871555026	no	564	0.106471499655167	325	NA	FT		NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene; protein abundance increases in response to DNA replication stress; YLR108C has a paralog, YDR132C, that arose from the whole genome duplication	biological_process	molecular_function	nucleus
YNR074C	YNR074C	AIF1	hom	Verified	1.31307433265816	0.0945789509412327	no	565	0.0961224048608546	362	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS|MITOCHONDRION|PLASMA MEMBRANE		Mitochondrial cell death effector that translocates to the nucleus in response to apoptotic stimuli, homolog of mammalian Apoptosis-Inducing Factor, putative reductase	response to singlet oxygen|positive regulation of apoptotic process	oxidoreductase activity, acting on a sulfur group of donors, NAD or NADP as acceptor	mitochondrion|nucleus|plasma membrane
YPR063C_p	YPR063C	YPR063C	hom	Uncharacterized	1.31305631890362	0.0945819856844058	no	566	0.105735420082472	405	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		ER-localized protein of unknown function	biological_process	molecular_function	endoplasmic reticulum
YGR173W	YGR173W	RBG2	hom	Verified	1.3119744744684	0.0947643736035392	no	567	0.0919336017665677	318	NA	FT	TRANSLATION			Protein with a role in translation; forms a complex with Gir2p; has similarity to mammalian developmentally regulated GTP-binding protein	cytoplasmic translation	GTP binding	cytoplasm
YLR433C	YLR433C	CNA1	hom	Verified	1.31123930325519	0.0948884637864496	no	568	0.071632911279382	349	NA	FT	SIGNALING|ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS			Calcineurin A; one isoform (the other is CMP2) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|fungal-type cell wall organization|cellular ion homeostasis	calcium-dependent protein serine/threonine phosphatase activity	calcineurin complex|cytoplasm
YDR352W	YDR352W	YPQ2	hom	Verified	1.30984872523965	0.0951235079663779	no	569	0.070427095178905	274	NA					Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; mutant phenotype is functionally complemented by rat PQLC2 vacuolar transporter	biological_process	molecular_function	fungal-type vacuole membrane|integral to membrane
YDR073W	YDR073W	SNF11	hom	Verified	1.30915286929188	0.0952412867299295	no	570	0.077614138826291	306	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RSC COMPLEX	Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p; relocates to the cytosol under hypoxic conditions	positive regulation of transcription from RNA polymerase II promoter	molecular_function	SWI/SNF complex
YER046W-A_d	YER046W-A	YER046W-A	hom	Dubious	1.30763493731025	0.0954985804677934	no	571	0.085000483244845	343	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPR172W_p	YPR172W	YPR172W	hom	Uncharacterized	1.30669917954053	0.0956574487242929	no	572	0.0893622324365823	422	NA	FT	OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM	NUCLEUS		Putative pyridoxal 5'-phosphate synthase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; YPR172W has a paralog, YLR456W, that arose from the whole genome duplication	biological_process	molecular_function	nucleus|cytoplasm
YPR066W	YPR066W	UBA3	hom	Verified	1.30306900237564	0.0962756025522633	no	573	0.106862971139819	400	NA					Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern	protein neddylation	NEDD8 activating enzyme activity	cytoplasm
YCR084C	YCR084C	TUP1	hom	Verified	1.30047829933703	0.0967185445821129	no	574	0.0901149169906311	358	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		General repressor of transcription, forms complex with Cyc8p, involved in the establishment of repressive chromatin structure through interactions with histones H3 and H4, appears to enhance expression of some genes	nucleosome positioning|regulation of transcription from RNA polymerase II promoter in response to osmotic stress|histone exchange|negative regulation of mating-type specific transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter by glucose|negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter in response to hypoxia|negative regulation of transcription from RNA polymerase II promoter during mitosis|Unknown	ubiquitin binding|histone deacetylase binding|histone binding|phosphatidylinositol-3,5-bisphosphate binding|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription|mediator complex binding	nucleus|transcriptional repressor complex
YOR142W	YOR142W	LSC1	hom	Verified	1.29622507985708	0.0974489756972791	no	575	0.0816847934610776	352	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Alpha subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated	tricarboxylic acid cycle|succinyl-CoA metabolic process	succinate-CoA ligase (ADP-forming) activity	mitochondrial nucleoid|mitochondrion
YKR097W	YKR097W	PCK1	hom	Verified	1.29439994525639	0.0977636547771322	no	576	0.0965029177038676	437	NA	FT	CARBOHYDRATE METABOLISM			Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol	gluconeogenesis	phosphoenolpyruvate carboxykinase (ATP) activity	cytosol
YDR314C	YDR314C	RAD34	hom	Verified	1.28980321225617	0.0985594961806264	no	577	0.092897806084289	327	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Protein involved in nucleotide excision repair (NER); homologous to RAD4	nucleotide-excision repair	molecular_function	nucleus
YBR062C_p	YBR062C	YBR062C	hom	Uncharacterized	1.28731268802326	0.0989926614521634	no	578	0.0806157036152753	323	NA					Protein of unknown function that interacts with Msb2p; may play a role in activation of the filamentous growth pathway.	biological_process	molecular_function	cellular_component
YMR320W_d	YMR320W	YMR320W	hom	Dubious	1.28689765303881	0.0990649817206134	no	579	0.086827572592105	396	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPL058C	YPL058C	PDR12	hom	Verified	1.28649325822898	0.0991354850917576	no	580	0.100058003848218	397	NA	FT	KETONE METABOLISM|NUCLEOTIDE METABOLISM	PLASMA MEMBRANE		Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity	propionate metabolic process|transport|organic acid transport	xenobiotic-transporting ATPase activity|organic acid transmembrane transporter activity	integral to membrane|plasma membrane
YDL149W	YDL149W	ATG9	hom	Verified	1.28583703428393	0.0992499711664447	no	581	0.0760770932960574	245	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS	ENDOMEMBRANE SYSTEM|MITOCHONDRION		Transmembrane protein involved in forming Cvt and autophagic vesicles; cycles between the phagophore assembly site (PAS) and other cytosolic punctate structures, not found in autophagosomes; may be involved in membrane delivery to the PAS	piecemeal microautophagy of nucleus|mitochondrion degradation|protein homooligomerization|CVT pathway|autophagic vacuole assembly	molecular_function	mitochondrion|integral to membrane|pre-autophagosomal structure
YJL158C	YJL158C	CIS3	hom	Verified	1.28553184527084	0.0993032479432862	no	582	0.0839741027341581	337	NA	FT	CELL WALL ORG/BIOGENESIS	ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family	fungal-type cell wall organization	structural constituent of cell wall	extracellular region|fungal-type cell wall|endoplasmic reticulum|plasma membrane|cellular bud tip
YIL064W	YIL064W	SEE1	hom	Verified	1.2828494542019	0.0997724120967618	no	583	0.111920168963291	422	NA	FT	VESICLE-MEDIATED TRANSPORT			Probable lysine methyltransferase involved in the dimethylation of eEF1A (Tef1p/Tef2p); sequence similarity to S-adenosylmethionine-dependent methyltransferases of the seven beta-strand family; role in vesicular transport	vesicle-mediated transport|peptidyl-lysine dimethylation	protein-lysine N-methyltransferase activity	cytoplasm
YDR349C	YDR349C	YPS7	hom	Verified	1.28000462582981	0.100271754516565	no	584	0.0969833587447953	398	NA	FT	CELL WALL ORG/BIOGENESIS|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative GPI-anchored aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; located in the cytoplasm and endoplasmic reticulum	fungal-type cell wall organization	aspartic-type endopeptidase activity	endoplasmic reticulum|cytoplasm
YNR018W	YNR018W	RCF2	hom	Verified	1.27818443900041	0.100592200771663	no	585	0.0903769587912187	358	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast	mitochondrial respiratory chain complex IV assembly	molecular_function	mitochondrion|mitochondrial respiratory chain supercomplex|mitochondrial respiratory chain complex IV|integral to mitochondrial inner membrane
YPR179C	YPR179C	HDA3	hom	Verified	1.27721549920792	0.100763088257489	no	586	0.0997320534721813	414	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|CHROMOSOME SEGREGATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex that contains an Hda1p homodimer and an Hda2p-Hda3p heterodimer; required for the activity of the complex; has similarity to Hda2p	negative regulation of transcription from RNA polymerase II promoter|chromosome segregation|gene silencing by RNA|gene silencing involved in chronological cell aging|histone deacetylation	histone deacetylase activity|chromatin binding|DNA binding	nucleus|HDA1 complex
YMR065W	YMR065W	KAR5	hom	Verified	1.27567268277979	0.101035624510828	no	587	0.0995352091237338	415	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION		Protein required for nuclear membrane fusion during karyogamy, localizes to the membrane with a soluble portion in the endoplasmic reticulum lumen, may form a complex with Jem1p and Kar2p; expression of the gene is regulated by pheromone	karyogamy involved in conjugation with cellular fusion	molecular_function	mitochondrion|endoplasmic reticulum membrane
YOR086C	YOR086C	TCB1	hom	Verified	1.27514129801282	0.101129617138076	no	588	0.080476197518301	307	NA	FT		ENDOPLASMIC RETICULUM|MITOCHONDRION|PLASMA MEMBRANE		Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains three calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact	biological_process	lipid binding	mitochondrion|plasma membrane|cortical endoplasmic reticulum
YPL186C	YPL186C	UIP4	hom	Verified	1.26919041275051	0.102186579808308	no	589	0.129501417430844	427	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION		Protein that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope	biological_process	molecular_function	mitochondrial outer membrane|nuclear envelope|endoplasmic reticulum
YOR034C	YOR034C	AKR2	hom	Verified	1.26834286941164	0.102337767047837	no	590	0.0830832805715704	331	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	GOLGI APPARATUS		Ankyrin repeat-containing protein; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; possibly involved in constitutive endocytosis of Ste3p; AKR2 has a paralog, AKR1, that arose from the whole genome duplication	endocytosis|protein palmitoylation	palmitoyltransferase activity	integral to membrane|Golgi apparatus
YCR034W	YCR034W	FEN1	hom	Verified	1.26809514397975	0.102381987736429	no	591	0.174185170914938	639	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|KETONE METABOLISM|LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway; FEN1 has a paralog, ELO1, that arose from the whole genome duplication	fatty acid elongation|vesicle-mediated transport|sphingolipid biosynthetic process	fatty acid elongase activity	integral to membrane|endoplasmic reticulum|endoplasmic reticulum membrane
YNR070W_p	YNR070W	PDR18	hom	Uncharacterized	1.26360881182586	0.103185234614734	no	592	0.0878257901153791	367	NA	FT	NUCLEOTIDE METABOLISM	MITOCHONDRION		Putative transporter of the ATP-binding cassette (ABC) family, implicated in pleiotropic drug resistance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	transport	ATPase activity, coupled to transmembrane movement of substances	mitochondrion|integral to membrane|membrane
YGR189C	YGR189C	CRH1	hom	Verified	1.26293423236744	0.1033064081242	no	593	0.0849297160927788	297	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress	fungal-type cell wall organization|cell wall chitin metabolic process	transferase activity, transferring glycosyl groups	incipient cellular bud site|fungal-type cell wall
YDR421W	YDR421W	ARO80	hom	Verified	1.26283738171927	0.103323813711581	no	594	0.0692082564830247	287	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Zinc finger transcriptional activator of the Zn2Cys6 family; activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids	aromatic amino acid family catabolic process|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|nucleic acid binding transcription factor activity	nucleus
YHR191C	YHR191C	CTF8	hom	Verified	1.26197040722117	0.103479717527332	no	595	0.138982428267619	493	NA	FT	CELL CYCLE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion	maintenance of DNA trinucleotide repeats|mitotic sister chromatid cohesion	molecular_function	Ctf18 RFC-like complex
YDR063W	YDR063W	AIM7	hom	Verified	1.26160333004936	0.103545778657139	no	596	0.082853512772065	307	NA	FT	CYTOSKELETON ORGANIZATION	NUCLEUS|CYTOSKELETON		Protein that interacts with Arp2/3 complex to stimulate actin filament debranching and inhibit actin nucleation; has similarity to Cof1p and also to human glia maturation factor (GMF); null mutant displays elevated mitochondrial genome loss	actin filament debranching|negative regulation of Arp2/3 complex-mediated actin nucleation	molecular_function	nucleus|actin cortical patch|cytoplasm
YGL235W_p	YGL235W	YGL235W	hom	Uncharacterized	1.25821650942517	0.104156732941846	no	597	0.0869605090594492	325	NA					Putative protein of unknown function; potential Cdc28p substrate; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2	biological_process	molecular_function	cellular_component
YOL106W_d	YOL106W	YOL106W	hom	Dubious	1.25773028062441	0.104244658650477	no	598	0.0920570916591564	370	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YHR177W_p	YHR177W	YHR177W	hom	Uncharacterized	1.25633045782537	0.104498091723152	no	599	0.106136337426801	399	NA					Putative protein of unknown function; overexpression causes a cell cycle delay or arrest	biological_process	molecular_function	cellular_component
YJL079C	YJL079C	PRY1	hom	Verified	1.24882501713438	0.105864540841946	no	600	0.0758868333773965	328	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY2; may be involved in detoxification of hydrophobic compounds; PRY1 has a paralog, PRY2, that arose from the whole genome duplication	biological_process	molecular_function	nuclear envelope|extracellular region|endoplasmic reticulum|fungal-type vacuole
YNL097C	YNL097C	PHO23	hom	Verified	1.24828444456723	0.105963454358976	no	601	0.09827480337018	440	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5; affects termination of snoRNAs and cryptic unstable transcripts (CUTs); C-terminus has similarity to human candidate tumor suppressor p33(ING1) and its isoform ING3	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of transcription from RNA polymerase I promoter|negative regulation of chromatin silencing at telomere|negative regulation of chromatin silencing at rDNA|chromatin modification|positive regulation of transcription from RNA polymerase II promoter	methylated histone residue binding	histone deacetylase complex|Rpd3L-Expanded complex|nucleus|Rpd3L complex
YJL065C	YJL065C	DLS1	hom	Verified	1.24506841368569	0.106553301770481	no	602	0.135216800942388	459	NA	FT	GENE SILENCING	NUCLEUS		Subunit of ISW2/yCHRAC chromatin accessibility complex; ISW2/yCHRAC also includes Itc1p, Isw2p, and Dpb4p; involved in inheritance of telomeric silencing; DLS1 has a paralog, DPB3, that arose from the whole genome duplication	chromatin silencing at telomere	molecular_function	chromatin accessibility complex|nucleus
YPR193C	YPR193C	HPA2	hom	Verified	1.24384790421242	0.106777772899522	no	603	0.0938907169348861	432	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION			Tetrameric histone acetyltransferase with similarity to Gcn5p, Hat1p, Elp3p, and Hpa3p; acetylates histones H3 and H4 in vitro and exhibits autoacetylation activity	protein homotetramerization|histone acetylation	histone acetyltransferase activity|protein homodimerization activity	cytoplasm
YBR186W	YBR186W	PCH2	hom	Verified	1.24094509695014	0.107313015816634	no	604	0.0725880776515927	273	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA; required for meiotic double-stranded break formation	meiotic recombination checkpoint|meiotic DNA double-strand break formation|reciprocal meiotic recombination	ATPase activity	nucleolus
YHR187W	YHR187W	IKI1	hom	Verified	1.23878854093108	0.107711909330666	no	605	0.109015452796899	436	NA	FT	RNA PROCESSING	NUCLEUS		Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin	tRNA modification	tRNA binding|ATPase activity	Elongator holoenzyme complex|nucleus|cytoplasm
YGL202W	YGL202W	ARO8	hom	Verified	1.23667328735242	0.108104199831036	no	606	0.0871229169186277	349	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis	aromatic amino acid family metabolic process	aromatic-amino-acid:2-oxoglutarate aminotransferase activity|2-aminoadipate transaminase activity	cytoplasm
YDR093W	YDR093W	DNF2	hom	Verified	1.23666760487293	0.108105255075267	no	607	0.0951605241003083	365	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase	intracellular protein transport|phospholipid translocation|endocytosis|establishment or maintenance of cell polarity	phospholipid-translocating ATPase activity	integral to membrane|plasma membrane
YJL007C_d	YJL007C	YJL007C	hom	Dubious	1.23594182565579	0.108240094235685	no	608	0.102603746308532	368	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YBR161W	YBR161W	CSH1	hom	Verified	1.23447716189042	0.108512575879709	no	609	0.0859944011784001	370	NA	FT	LIPID METABOLISM			Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Sur1p; CSH1 has a paralog, SUR1, that arose from the whole genome duplication	glycosphingolipid biosynthetic process|sphingolipid biosynthetic process	mannosyltransferase activity|transferase activity, transferring glycosyl groups	integral to membrane|fungal-type vacuole
YFL049W	YFL049W	SWP82	hom	Verified	1.23292987815798	0.108800963527144	no	610	0.0952337953925986	358	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS	RSC COMPLEX	Member of the SWI/SNF chromatin remodeling complex; has an as yet unidentified role in the complex; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p; relocates to the cytosol under hypoxic conditions	positive regulation of transcription from RNA polymerase II promoter	molecular_function	SWI/SNF complex|nucleus
YDR344C_d	YDR344C	YDR344C	hom	Dubious	1.22897077107117	0.109541382531578	no	611	0.106950062256914	394	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPR152C	YPR152C	URN1	hom	Verified	1.22779002396106	0.109762900776761	no	612	0.104218073183398	358	NA	FT	RNA PROCESSING	NUCLEUS		Putative protein of unknown function containing WW and FF domains; overexpression causes accumulation of cells in G1 phase	biological_process	molecular_function	nucleus
YCL024W	YCL024W	KCC4	hom	Verified	1.22731015321451	0.109853020464561	no	613	0.107909458969657	406	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein kinase of the bud neck involved in the septin checkpoint; associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p; KCC4 has a paralog, GIN4, that arose from the whole genome duplication	budding cell bud growth|protein phosphorylation|septin checkpoint|septin ring assembly	phosphatidic acid binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|protein kinase activity	incipient cellular bud site|cellular bud neck septin collar|plasma membrane|cellular bud neck|septin ring
YBL027W	YBL027W	RPL19B	hom	Verified	1.22676362578797	0.10995572293804	no	614	0.104105685507959	393	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L19B; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19B has a paralog, RPL19A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YNL067W	YNL067W	RPL9B	hom	Verified	1.22664048777028	0.109978872325495	no	615	0.0736019172055907	305	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L9B; nearly identical to paralog Rpl9Ap; homologous to mammalian ribosomal protein L9 and bacterial L6	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YHR077C	YHR077C	NMD2	hom	Verified	1.22466993713273	0.110349802743426	no	616	0.109132408976996	416	NA					Protein involved in the nonsense-mediated mRNA decay (NMD) pathway; interacts with Nam7p and Upf3p; involved in telomere maintenance	nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|translational frameshifting	molecular_function	polysome|cytoplasm
YGR152C	YGR152C	RSR1	hom	Verified	1.2236472251244	0.110542668152281	no	617	0.109018776443998	372	NA	FT	CELL CYCLE|SIGNALING|CELL DIVISION|NUCLEOTIDE METABOLISM	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases	bipolar cellular bud site selection|small GTPase mediated signal transduction|axial cellular bud site selection|cellular bud site selection	GTPase activity|signal transducer activity	plasma membrane|cellular bud neck
YHR204W	YHR204W	MNL1	hom	Verified	1.22250317806507	0.110758701401267	no	618	0.104804270954435	462	NA	FT	PROTEOLYSIS	ENDOPLASMIC RETICULUM		Alpha-1,2-specific exomannosidase of the endoplasmic reticulum; in complex with Pdi1p, generates a Man7GlcNac2 oligosaccharide signal on glycoproteins destined for ubiquitin-proteasome degradation	ER-associated protein catabolic process	carbohydrate binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	endoplasmic reticulum lumen
YER076C_p	YER076C	YER076C	hom	Uncharacterized	1.22170836123653	0.110908966627475	no	619	0.106117834352723	363	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; analysis of HA-tagged protein suggests a membrane localization	biological_process	molecular_function	mitochondrion
YDR090C_p	YDR090C	YDR090C	hom	Uncharacterized	1.21997987042786	0.111236252917358	no	620	0.127584694076805	457	NA	FT		PLASMA MEMBRANE		Putative protein of unknown function	biological_process	molecular_function	integral to membrane
YJL176C	YJL176C	SWI3	hom	Verified	1.21752188985203	0.111702856539651	no	621	0.14215231425568	491	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS	NUCLEUS	RSC COMPLEX	Subunit of the SWI/SNF chromatin remodeling complex; SWI/SNF regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; relocates to the cytosol under hypoxic conditions	cellular alcohol catabolic process|ATP-dependent chromatin remodeling|positive regulation of mating type switching|sucrose catabolic process|carbon catabolite activation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	histone binding|DNA binding	SWI/SNF complex|nucleus
YLR179C	YLR179C	YLR179C	hom	Verified	1.21649632268923	0.111897955510692	no	622	0.0767725879547543	295	NA	FT		NUCLEUS		Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus	biological_process	molecular_function	nucleus|cytoplasm
YGL242C_p	YGL242C	YGL242C	hom	Uncharacterized	1.21632648258655	0.111930288580486	no	623	0.133342516047069	424	NA					Putative protein of unknown function; deletion mutant is viable	biological_process	molecular_function	cellular_component
YOR015W_d	YOR015W	YOR015W	hom	Dubious	1.21454500835853	0.112269836818619	no	624	0.10097696370031	395	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR294C	YDR294C	DPL1	hom	Verified	1.21283907268455	0.112595676785315	no	625	0.0900725346714608	311	NA	FT	KETONE METABOLISM|LIPID METABOLISM|SIGNALING|RESPONSE TO NUTRIENT LEVELS	ENDOPLASMIC RETICULUM		Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate	calcium-mediated signaling|sphingolipid metabolic process|cellular response to starvation	sphinganine-1-phosphate aldolase activity	endoplasmic reticulum|cortical endoplasmic reticulum|perinuclear endoplasmic reticulum
YOR130C	YOR130C	ORT1	hom	Verified	1.20925887493504	0.113281702575949	no	626	0.0944088333952062	400	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Ornithine transporter of the mitochondrial inner membrane, exports ornithine from mitochondria as part of arginine biosynthesis; human ortholog is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome	arginine biosynthetic process|mitochondrial ornithine transport	L-ornithine transmembrane transporter activity	mitochondrial envelope|integral to membrane
YDR466W	YDR466W	PKH3	hom	Verified	1.20919158338885	0.113294625247512	no	627	0.172727244542606	592	NA	FF|FT	SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION			Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant	MAPK cascade involved in cell wall biogenesis|protein phosphorylation	protein kinase activity	cellular_component
YJL049W_p	YJL049W	YJL049W	hom	Uncharacterized	1.20755726671713	0.113608802460925	no	628	0.0752144120379479	288	NA	FT	PROTEIN LOCALIZATION			Putative protein of unknown function; YJL049W is a non-essential gene	biological_process	molecular_function	cellular_component
YDL201W	YDL201W	TRM8	hom	Verified	1.20258018963047	0.114569408793022	no	629	0.0912510087907994	320	NA	FT	RNA PROCESSING	NUCLEUS		Noncatalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p	tRNA methylation	tRNA (guanine-N7-)-methyltransferase activity	tRNA methyltransferase complex|nucleus
YDL006W	YDL006W	PTC1	hom	Verified	1.20046777699596	0.114978859945322	no	630	0.190392772170501	683	NA	FF|FT	RNA PROCESSING|SIGNALING|MITOCHONDRION ORGANIZATION|PROTEIN PHOSPHORYLATION	NUCLEUS		Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p, inactivating osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing, mitochondrial inheritance, and sporulation	mitochondrion inheritance|inactivation of MAPK activity involved in osmosensory signaling pathway|pheromone-dependent signal transduction involved in conjugation with cellular fusion|tRNA splicing, via endonucleolytic cleavage and ligation|protein dephosphorylation	protein serine/threonine phosphatase activity	nucleus|cytoplasm
YJL053W	YJL053W	PEP8	hom	Verified	1.19616421601495	0.115816241045404	no	631	0.130277241062383	519	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM		Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress	protein retention in Golgi apparatus|retrograde transport, endosome to Golgi	protein transporter activity	endosome|retromer complex, inner shell|retromer complex
YDR130C	YDR130C	FIN1	hom	Verified	1.19488623634776	0.116065740552028	no	632	0.11434718691309	426	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME|CYTOSKELETON	KINETOCHORE	Spindle pole body-related intermediate filament protein; forms cell cycle-specific filaments between spindle pole bodies in dividing cells; localizes to poles and microtubules of spindle during anaphase and contributes to spindle stability; involved in Glc7p localization and regulation; relative distribution to the nucleus increases upon DNA replication stress	intermediate filament cytoskeleton organization|mitotic cell cycle spindle checkpoint|mitotic spindle stabilization|mitotic sister chromatid segregation	microtubule binding|structural constituent of cytoskeleton	spindle microtubule|condensed nuclear chromosome kinetochore|intermediate filament|nucleus|spindle pole body|astral microtubule|spindle
YGR139W_d	YGR139W	YGR139W	hom	Dubious	1.19422114454062	0.116195737022772	no	633	0.0870278691319559	350	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDL182W	YDL182W	LYS20	hom	Verified	1.19401254684994	0.116236530060337	no	634	0.089640277855523	331	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS|MITOCHONDRION		Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS20 has a paralog, LYS21, that arose from the whole genome duplication	lysine biosynthetic process via aminoadipic acid	homocitrate synthase activity	mitochondrion|nucleus
YLR398C	YLR398C	SKI2	hom	Verified	1.18771414850552	0.117473023832839	no	635	0.124839385334932	433	NA	FT	TRANSLATION			Ski complex component and putative RNA helicase, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay	nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, non-stop decay	RNA helicase activity	Ski complex
YDR105C	YDR105C	TMS1	hom	Verified	1.18699266785417	0.117615256323698	no	636	0.125621318588504	429	NA					Vacuolar membrane protein of unknown function that is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p, a protein involved in multidrug resistance	biological_process	molecular_function	fungal-type vacuole membrane|integral to membrane|membrane
YDR297W	YDR297W	SUR2	hom	Verified	1.18693994883911	0.117625654112474	no	637	0.132043464372606	460	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis	sphingolipid metabolic process	sphingosine hydroxylase activity	integral to membrane|endoplasmic reticulum membrane
YLR064W	YLR064W	PER33	hom	Verified	1.18589922276608	0.117831050079813	no	638	0.109408551004034	417	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	NUCLEAR PORE	Protein that localizes to the endoplasmic reticulum; also associates with the nuclear pore complex; deletion extends chronological lifespan; highly conserved across species, orthologous to human TMEM33 and paralogous to Pom33p; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	integral to membrane|endoplasmic reticulum|nuclear pore
YMR007W_d	YMR007W	YMR007W	hom	Dubious	1.18537033065384	0.117935528550087	no	639	0.0817328669148363	346	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKR013W	YKR013W	PRY2	hom	Verified	1.18509361729232	0.117990217201946	no	640	0.146883673168877	527	NA					Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY1; may be involved in detoxification of hydrophobic compounds; PRY2 has a paralog, PRY1, that arose from the whole genome duplication	biological_process	molecular_function	extracellular region|fungal-type vacuole
YNR020C	YNR020C	ATP23	hom	Verified	1.18199839656455	0.118603168541299	no	641	0.138858114927274	475	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Putative metalloprotease of the mitochondrial inner membrane, required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex; substrate of the Mia40p-Erv1p disulfide relay system, and folding is assisted by Mia40p	protein processing|mitochondrial proton-transporting ATP synthase complex assembly	metalloendopeptidase activity	mitochondrial inner membrane|mitochondrial intermembrane space
YDR032C	YDR032C	PST2	hom	Verified	1.18149160711284	0.118703742813464	no	642	0.105028931376923	428	NA	FT	OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrion|membrane raft|plasma membrane|cytoplasm
YMR052C-A_d	YMR052C-A	YMR052C-A	hom	Dubious	1.18148736622216	0.118704584688304	no	643	0.117219875750641	479	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPL023C	YPL023C	MET12	hom	Verified	1.1813754662157	0.118726799895083	no	644	0.125143841805132	454	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS			Protein with methylenetetrahydrofolate reductase (MTHFR) activity in vitro; null mutant has no phenotype and is prototrophic for methionine; MET13 encodes major isozyme of MTHFR	biological_process	methylenetetrahydrofolate reductase (NADPH) activity	cellular_component
YGR125W_p	YGR125W	YGR125W	hom	Uncharacterized	1.18106261192115	0.118788925599858	no	645	0.119098544184298	487	NA					Putative protein of unknown function; deletion mutant has decreased rapamycin resistance but normal wormannin resistance; green fluorescent protein (GFP)-fusion protein localizes to the vacuole	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YFR025C	YFR025C	HIS2	hom	Verified	1.17997062382961	0.119005949393332	no	646	0.0985574686385907	329	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Histidinolphosphatase, catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control	histidine biosynthetic process	histidinol-phosphatase activity	intracellular
YKR017C	YKR017C	HEL1	hom	Verified	1.17959685951811	0.119080296298445	no	647	0.122236114044664	472	NA					RING finger ubiquitin ligase (E3); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU)	biological_process	molecular_function	cellular_component
YDL170W	YDL170W	UGA3	hom	Verified	1.17953591606635	0.119092421904859	no	648	0.114186647436641	378	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Transcriptional activator necessary for gamma-aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1, UGA2, UGA4); zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus	nitrogen utilization|nitrogen catabolite activation of transcription from RNA polymerase II promoter|gamma-aminobutyric acid catabolic process	sequence-specific DNA binding transcription factor recruiting transcription factor activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YOL115W	YOL115W	PAP2	hom	Verified	1.17614710692422	0.119768048258665	no	649	0.134303040280718	522	NA	FT	CELL CYCLE|RNA PROCESSING|RESPONSE TO DNA DAMAGE|CELL DIVISION	NUCLEUS		Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Trf5p	polyadenylation-dependent mRNA catabolic process|nuclear polyadenylation-dependent CUT catabolic process|base-excision repair|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent snRNA catabolic process|ncRNA polyadenylation|histone mRNA catabolic process|nuclear polyadenylation-dependent mRNA catabolic process|nuclear polyadenylation-dependent antisense transcript catabolic process|U4 snRNA 3'-end processing|nuclear mRNA surveillance of mRNA 3'-end processing|polyadenylation-dependent snoRNA 3'-end processing|snoRNA polyadenylation|tRNA modification	5'-deoxyribose-5-phosphate lyase activity|polynucleotide adenylyltransferase activity	nucleolus|nucleus|TRAMP complex
YPR198W	YPR198W	SGE1	hom	Verified	1.17574131073014	0.119849132621311	no	650	0.167330126374605	637	NA	FF|FT		PLASMA MEMBRANE		Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations	response to drug|drug transport	drug transmembrane transporter activity	integral to membrane|integral to plasma membrane
YBR118W	YBR118W	TEF2	hom	Verified	1.17317791437323	0.120362233381753	no	651	0.102478440267608	331	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM|RNA LOCALIZATION	CYTOSKELETON	RIBOSOME	Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus; TEF2 has a paralog, TEF1, that arose from the whole genome duplication	translational elongation|tRNA export from nucleus	GDP binding|GTP binding|translation elongation factor activity	ribosome|eukaryotic translation elongation factor 1 complex|cytoplasm
YNL254C	YNL254C	RTC4	hom	Verified	1.17056524811798	0.120886786451399	no	652	0.094730983554267	366	NA	FT		NUCLEUS		Protein of unknown function; null mutation suppresses cdc13-1 temperature sensitivity; (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	biological_process	molecular_function	nucleus|cytoplasm
YKR019C	YKR019C	IRS4	hom	Verified	1.16915515370149	0.121170562962514	no	653	0.298717046070642	1065	NA	FF|FT	LIPID METABOLISM|SIGNALING|CELL WALL ORG/BIOGENESIS|RESPONSE TO NUTRIENT LEVELS|GENE SILENCING	MITOCHONDRION		EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication	autophagy|fungal-type cell wall organization|chromatin silencing at rDNA|inositol lipid-mediated signaling|CVT pathway|cellular response to starvation	molecular_function	mitochondrion|pre-autophagosomal structure
YNL041C	YNL041C	COG6	hom	Verified	1.16754242483377	0.121495692939554	no	654	0.276437418197624	963	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments	intra-Golgi vesicle-mediated transport|CVT pathway	molecular_function	Golgi transport complex
YKL081W	YKL081W	TEF4	hom	Verified	1.16730785255879	0.121543034307018	no	655	0.131377176143146	449	NA	FT	TRANSLATION	MITOCHONDRION	RIBOSOME	Gamma subunit of translational elongation factor eEF1B, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex	translational elongation	translation elongation factor activity	mitochondrion|ribosome|eukaryotic translation elongation factor 1 complex
YDL125C	YDL125C	HNT1	hom	Verified	1.1655240623206	0.121903463004186	no	656	0.121853973587738	445	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		Adenosine 5'-monophosphoramidase; interacts physically and genetically with Kin28p, a CDK and TFIIK subunit, and genetically with CAK1; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins and similar to Hint; protein abundance increases in response to DNA replication stress	nucleotide metabolic process	hydrolase activity|nucleotide binding	nucleus|cytoplasm
YMR315W	YMR315W	YMR315W	hom	Verified	1.16266230584535	0.122483270407325	no	657	0.12671215536757	469	NA	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	NUCLEUS		Protein with NADP(H) oxidoreductase activity; transcription is regulated by Stb5p in response to NADPH depletion induced by diamide; promoter contains a putative Stb5p binding site; protein abundance increases in response to DNA replication stress	NADPH regeneration	oxidoreductase activity	nucleus|cytoplasm
YDR333C	YDR333C	RQC1	hom	Verified	1.16099527577363	0.122821910327246	no	658	0.107616630677939	352	NA					Component of the ribosome quality control complex (RQC); RQC (Rqc1p-Ltn1p-Tae2p-Cdc48p-Npl4p-Ufd1p), is a ribosome-bound complex required for the degradation of polypeptides arising from stalled translation; required along with Ltn1p for recruitment of the Cdc48p-Npl4p-Ufd1p AAA ATPase complex to the RQC	biological_process	molecular_function	cytoplasm
YHR123W	YHR123W	EPT1	hom	Verified	1.15921326667298	0.12318463253286	no	659	0.0928924460131474	364	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability; EPT1 has a paralog, CPT1, that arose from the whole genome duplication	phosphatidylethanolamine biosynthetic process|phosphatidylcholine biosynthetic process	ethanolaminephosphotransferase activity|diacylglycerol cholinephosphotransferase activity	integral to membrane|Golgi apparatus
YEL041W	YEL041W	YEF1	hom	Verified	1.15738904255671	0.123556724395224	no	660	0.148743588005241	503	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			ATP-NADH kinase; phosphorylates both NAD and NADH; homooctameric structure consisting of 60-kDa subunits; similar to Pos5p; overexpression complements certain pos5 phenotypes; YEF1 has a paralog, UTR1, that arose from the whole genome duplication	NADP biosynthetic process	NAD+ kinase activity|NADH kinase activity	cellular_component
YMR053C	YMR053C	STB2	hom	Verified	1.1569413030033	0.123648171211504	no	661	0.113402928571954	454	NA	FT		NUCLEUS|CHROMOSOME		Protein that interacts with Sin3p in a two-hybrid assay and is part of a large protein complex with Sin3p and Stb1p	biological_process	molecular_function	Sin3-type complex
YOR013W_d	YOR013W	IRC11	hom	Dubious	1.15544341096703	0.12395444676693	no	662	0.0985104272950285	417	NA					Dubious opening reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YOR012C; null mutant displays increased levels of spontaneous Rad52 foci	Unknown	Unknown	Unknown
YMR242C	YMR242C	RPL20A	hom	Verified	1.15265553439394	0.124525899619242	no	663	0.126127000079775	520	NA	FF|FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L20A; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20A has a paralog, RPL20B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YBR012C_d	YBR012C	YBR012C	hom	Dubious	1.1502774281717	0.125014812228245	no	664	0.125331179723469	421	NA					Dubious open reading frame, unlikely to encode a functional protein; expression induced by iron-regulated transcriptional activator Aft2p	Unknown	Unknown	Unknown
YLR425W	YLR425W	TUS1	hom	Verified	1.14942708877115	0.125189957706501	no	665	0.176987271759376	646	NA	FT	SIGNALING|CELL WALL ORG/BIOGENESIS	SITE OF POLARIZED GROWTH		Guanine nucleotide exchange factor (GEF) that modulate Rho1p activity; involved in the cell integrity signaling pathway; interacts with Rgl1p; localization of Tus1p to the bed neck is regulated by Rgl1p; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate	fungal-type cell wall organization|signal transduction	Rho guanyl-nucleotide exchange factor activity	incipient cellular bud site|cellular bud neck
YER107C	YER107C	GLE2	hom	Verified	1.14711949506101	0.125666118851887	no	666	0.181955434189694	657	NA	FF|FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	RNA export factor associated with the nuclear pore complex (NPC); associates with NUP116p; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p and human RAE1	poly(A)+ mRNA export from nucleus|Unknown|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|nuclear pore distribution|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	molecular_function	integral to membrane|nuclear pore|cytoplasm
YKR018C	YKR018C	YKR018C	hom	Verified	1.14607349427891	0.125882371872243	no	667	0.120030763365463	454	NA	FT		NUCLEUS|MITOCHONDRION		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress; YKR018C has a paralog, IML2, that arose from the whole genome duplication	biological_process	molecular_function	nucleus|cytoplasm
YPL025C_d	YPL025C	YPL025C	hom	Dubious	1.14581953136185	0.125934915983071	no	668	0.133674480630425	480	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR266C	YDR266C	HEL2	hom	Verified	1.14471485667384	0.126163647564006	no	669	0.131585500296894	423	NA					RING finger ubiquitin ligase (E3); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; computational analysis suggests a role as a transcription factor	biological_process	molecular_function	ribosome|cytoplasm
YGR087C	YGR087C	PDC6	hom	Verified	1.14414396866937	0.126281967843647	no	670	0.121849611009516	439	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation	L-phenylalanine catabolic process|ethanol metabolic process|tryptophan catabolic process|aromatic amino acid family catabolic process to alcohol via Ehrlich pathway	pyruvate decarboxylase activity	cytoplasm
YOR227W	YOR227W	HER1	hom	Verified	1.14242735025123	0.126638214039634	no	671	0.134989605014349	468	NA	FT		MITOCHONDRION		Protein of unknown function required for proliferation or remodeling of the ER that is caused by overexpression of Hmg2p; may interact with ribosomes, based on co-purification experiments; HER1 has a paralog, GIP3, that arose from the whole genome duplication	endoplasmic reticulum organization	molecular_function	mitochondrion|ribosome|cytoplasm
YDR025W	YDR025W	RPS11A	hom	Verified	1.14208928663242	0.126708454080726	no	672	0.133967720541885	466	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11A has a paralog, RPS11B, that arose from the whole genome duplication	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal small subunit assembly	structural constituent of ribosome	cytosolic small ribosomal subunit|90S preribosome
YOR317W	YOR317W	FAA1	hom	Verified	1.14039768710301	0.127060328019193	no	673	0.129063676508755	503	NA	FT	KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Long chain fatty acyl-CoA synthetase; activates imported fatty acids with a preference for C12:0-C16:0 chain lengths; functions in long chain fatty acid import; accounts for most acyl-CoA synthetase activity; localized to lipid particles; involved in sphingolipid-to-glycerolipid metabolism; forms ER foci upon DNA replication stress; FAA1 has a paralog, FAA4, that arose from the whole genome duplication	long-chain fatty acid transport|long-chain fatty-acyl-CoA metabolic process	long-chain fatty acid-CoA ligase activity	mitochondrial outer membrane|mitochondrion|lipid particle|plasma membrane
YOR175C	YOR175C	ALE1	hom	Verified	1.13986250151137	0.12717179481392	no	674	0.131318588471226	488	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Broad-specificity lysophospholipid acyltransferase, part of MBOAT family of membrane-bound O-acyltransferases; key component of Lands cycle; may have role in fatty acid exchange at sn-2 position of mature glycerophospholipids	glycerophospholipid biosynthetic process	1-acylglycerophosphocholine O-acyltransferase activity|O-acyltransferase activity|1-acylglycerol-3-phosphate O-acyltransferase activity	integral to membrane|ribosome|endoplasmic reticulum
YPL170W	YPL170W	DAP1	hom	Verified	1.13852698539291	0.127450248642311	no	675	0.151781656022092	575	NA	FT	LIPID METABOLISM			Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis	regulation of ergosterol biosynthetic process	heme binding	endosome|membrane
YOL132W	YOL132W	GAS4	hom	Verified	1.13667348579425	0.127837403656755	no	676	0.115539639901262	429	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	PLASMA MEMBRANE		1,3-beta-glucanosyltransferase, involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall	ascospore wall assembly	1,3-beta-glucanosyltransferase activity	fungal-type cell wall|integral to membrane
YFL056C	YFL056C	AAD6	hom	Verified	1.13442563916338	0.128308024660575	no	677	0.123383698447066	475	NA	FT	OXIDATION-REDUCTION PROCESS			Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin	cellular aldehyde metabolic process	aryl-alcohol dehydrogenase (NAD+) activity	cellular_component
YKL188C	YKL188C	PXA2	hom	Verified	1.13346616662953	0.128509270755491	no	678	0.115515762114998	425	NA	FT	NUCLEOTIDE METABOLISM			Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter ABCD1 and ABCD2 and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder	fatty acid transport	ATPase activity, coupled to transmembrane movement of substances	integral to membrane|integral to peroxisomal membrane
YIL076W	YIL076W	SEC28	hom	Verified	1.13232170446014	0.128749604181024	no	679	0.122234351979588	476	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth; protein abundance increases in response to DNA replication stress	late endosome to vacuole transport via multivesicular body sorting pathway|ER to Golgi vesicle-mediated transport|vesicle coating	molecular_function	endosome|COPI vesicle coat
YKL201C	YKL201C	MNN4	hom	Verified	1.129754365429	0.129289871077555	no	680	0.124557862775833	417	NA	FT	CARBOHYDRATE METABOLISM			Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication	protein O-linked glycosylation|protein N-linked glycosylation|response to stress	molecular_function	membrane
YDL177C_p	YDL177C	YDL177C	hom	Uncharacterized	1.12798661386585	0.129662786232102	no	681	0.105445795740857	415	NA					Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene	biological_process	molecular_function	cellular_component
YPL064C	YPL064C	CWC27	hom	Verified	1.1277451825512	0.129713775019138	no	682	0.145186005257482	493	NA	FT	RNA PROCESSING	NUCLEUS		Component of a complex containing Cef1p; putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	U2-type spliceosomal complex
YOL036W_p	YOL036W	YOL036W	hom	Uncharacterized	1.12581176751665	0.130122601089239	no	683	0.128163231445117	467	NA					Protein of unknown function; potential Cdc28p substrate; YOL036W has a paralog, YIR016W, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YPL110C	YPL110C	GDE1	hom	Verified	1.12496812306901	0.130301271235128	no	684	0.132399397964565	469	NA	FT	LIPID METABOLISM|SIGNALING|CARBOHYDRATE METABOLISM			Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes	glycerophospholipid catabolic process	glycerophosphocholine phosphodiesterase activity	ribosome|cytoplasm
YNR061C	YNR061C	YNR061C	hom	Verified	1.12401831789574	0.130502627511463	no	685	0.116894139001065	440	NA					Protein of unknown function; relocalizes from vacuole to cytoplasm upon DNA replication stress	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YAR029W_p	YAR029W	YAR029W	hom	Uncharacterized	1.12343914114015	0.13062551706952	no	686	0.120973639178503	467	NA					Member of DUP240 gene family but contains no transmembrane domains; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	biological_process	molecular_function	cytoplasm
YDR162C	YDR162C	NBP2	hom	Verified	1.12281590345518	0.130757844808734	no	687	0.221917922728166	765	NA	FF|FT	PROTEIN PHOSPHORYLATION	NUCLEUS		Protein involved in the HOG (high osmolarity glycerol) pathway; negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex; interacts with Bck1p and down regulates the cell wall integrity pathway; found in the nucleus and cytoplasm, contains an SH3 domain and a Ptc1p binding domain (PBM)	negative regulation of protein kinase activity|response to heat|hyperosmotic response	molecular_function	nucleus|cytoplasm
YDR538W	YDR538W	PAD1	hom	Verified	1.12123307920442	0.131094331314008	no	688	0.122390834305428	514	NA	FT	KETONE METABOLISM	MITOCHONDRION		Phenylacrylic acid decarboxylase, confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives; also has mRNA binding activity; homolog of E. coli UbiX	cinnamic acid catabolic process|aromatic compound catabolic process	mRNA binding|carboxy-lyase activity	mitochondrion
YLR392C	YLR392C	ART10	hom	Verified	1.12061332649996	0.131226244970655	no	689	0.0955853430947564	383	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION			Protein of unknown function that contains 2 PY motifs and is ubiquinated by Rsp5p; overexpression confers resistance to arsenite; green fluorescent protein (GFP)-fusion protein localizes it to the cytoplasm; non-essential gene	biological_process	molecular_function	cytoplasm
YNL091W	YNL091W	NST1	hom	Verified	1.11941577325437	0.131481402464717	no	690	0.128698949091051	498	NA					Protein of unknown function, mediates sensitivity to salt stress; interacts physically with the splicing factor Msl1p and also displays genetic interaction with MSL1	response to salt stress	molecular_function	cytoplasm
YMR006C	YMR006C	PLB2	hom	Verified	1.11607340660789	0.132195357161572	no	691	0.102162173565422	379	NA	FT	LIPID METABOLISM			Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine	glycerophospholipid metabolic process	lysophospholipase activity	extracellular region|fungal-type cell wall
YGR223C	YGR223C	HSV2	hom	Verified	1.11526831971747	0.132367728474482	no	692	0.139243189052065	508	NA	FT	MEMBRANE ORGANIZATION|RESPONSE TO NUTRIENT LEVELS			Phosphatidylinositol 3,5-bisphosphate-binding protein, plays a role in micronucleophagy; belongs to the PROPPIN family of proteins; predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization	piecemeal microautophagy of nucleus	phosphatidylinositol binding	endosome|fungal-type vacuole|extrinsic to membrane|cytoplasm
YKL105C	YKL105C	SEG2	hom	Verified	1.11120285680934	0.133240520926207	no	693	0.113888368550007	399	NA					Eisosome component and paralog of Seg1p; likely plays only minor role in eisosome assembly; shown to interact with Seg1p; similar to A. gossypii SEG gene which is important for stabilizing eisosomes	biological_process	molecular_function	cellular_component
YGL057C	YGL057C	GEP7	hom	Verified	1.11073652337858	0.133340888133937	no	694	0.145289367016786	499	NA	FT		MITOCHONDRION		Protein of unknown function; null mutant exhibits a respiratory growth defect and synthetic interactions with prohibitin (phb1) and gem1; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YNL173C	YNL173C	MDG1	hom	Verified	1.11062599157886	0.133364685104825	no	695	0.148249781498468	536	NA	FT	SIGNALING	PLASMA MEMBRANE		Plasma membrane protein involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations	pheromone-dependent signal transduction involved in conjugation with cellular fusion	molecular_function	membrane raft|plasma membrane
YKR043C	YKR043C	SHB17	hom	Verified	1.10410082556168	0.134774701602772	no	696	0.175064864518156	597	NA	FT	CARBOHYDRATE METABOLISM	NUCLEUS		Sedoheptulose bisphosphatase involved in riboneogenesis; dephosphorylates sedoheptulose 1,7-bisphosphate, which is converted via the nonoxidative pentose phosphate pathway to ribose-5-phosphate; facilitates the conversion of glycolytic intermediates to pentose phosphate units; also has fructose 1,6-bisphosphatase activity but this is probably not biologically relevant, since deletion does not affect FBP levels; GFP-fusion protein localizes to the cytoplasm and nucleus	ribose phosphate biosynthetic process	sedoheptulose-bisphosphatase activity	nucleus|cytoplasm
YGR112W	YGR112W	SHY1	hom	Verified	1.10295500870448	0.135023351934879	no	697	0.104674747014096	372	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome	mitochondrial respiratory chain complex IV assembly|aerobic respiration	unfolded protein binding	mitochondrion|integral to membrane|mitochondrial inner membrane
YNL085W	YNL085W	MKT1	hom	Verified	1.10102925266602	0.135441962935301	no	698	0.129795764996524	495	NA	FT	RESPONSE TO DNA DAMAGE|TRANSLATION			Protein that forms a complex with Pbp1p; complex may mediate posttranscriptional regulation of HO; involved in propagation of M2 dsRNA satellite of L-A virus; allelic variation affects mitochondrial genome stability, drug resistance, and more; forms cytoplasmic foci upon DNA replication stress	positive regulation of translation|interspecies interaction between organisms|response to DNA damage stimulus	nuclease activity	polysome|cytoplasm
YLR200W	YLR200W	YKE2	hom	Verified	1.09887645495352	0.135910978945087	no	699	0.178584622771113	635	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS	NUCLEUS		Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin	protein folding|tubulin complex assembly	tubulin binding	prefoldin complex|cytoplasm
YLR038C	YLR038C	COX12	hom	Verified	1.09456482017537	0.136853667498049	no	700	0.138388671658876	497	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Subunit VIb of cytochrome c oxidase; cytochrome c oxidase is also known as respiratory Complex IV and is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated; easily released from the intermembrane space, suggesting a loose association with Complex IV	mitochondrial respiratory chain complex IV assembly	cytochrome-c oxidase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YKR044W	YKR044W	UIP5	hom	Verified	1.09448952302452	0.136870169948778	no	701	0.126163883609636	434	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS		Protein of unknown function that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates	biological_process	molecular_function	nuclear envelope
YCR069W	YCR069W	CPR4	hom	Verified	1.08599813445815	0.138739908802236	no	702	0.126873873624591	463	NA					Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway	biological_process	peptidyl-prolyl cis-trans isomerase activity	membrane
YDR306C_p	YDR306C	YDR306C	hom	Uncharacterized	1.08526793608153	0.138901501373181	no	703	0.156602670298868	525	NA	FT	PROTEOLYSIS			F-box protein of unknown function; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity|protein binding, bridging	SCF ubiquitin ligase complex
YNL125C	YNL125C	ESBP6	hom	Verified	1.08176242047067	0.139679054429216	no	704	0.133940040163747	472	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane	transport	monocarboxylic acid transmembrane transporter activity|transporter activity	mitochondrion|integral to membrane|endoplasmic reticulum|membrane
YKL091C	YKL091C	YKL091C	hom	Verified	1.08088792047316	0.139873486276414	no	705	0.144145915265626	508	NA	FT		NUCLEUS		Putative homolog of Sec14p, which is a phosphatidylinositol/phosphatidylcholine transfer protein involved in lipid metabolism; localizes to the nucleus; contains a CRAL/TRIO domain and binds several lipids in a large-scale study	biological_process	phosphatidylcholine binding|phosphatidylinositol transporter activity|phosphatidylinositol binding|phosphatidylcholine transporter activity	nucleus
YER085C_p	YER085C	YER085C	hom	Uncharacterized	1.07994775383697	0.140082723207959	no	706	0.11600537374556	423	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YOR385W_p	YOR385W	YOR385W	hom	Uncharacterized	1.07968631307054	0.140140945412171	no	707	0.14237830557208	550	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YOR385W is not an essential gene	biological_process	molecular_function	cytoplasm
YJR149W_p	YJR149W	YJR149W	hom	Uncharacterized	1.07606793837979	0.140948436670576	no	708	0.107214700586111	360	NA	FT	OXIDATION-REDUCTION PROCESS			Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YOR166C	YOR166C	SWT1	hom	Verified	1.07546808122712	0.141082607604279	no	709	0.12069177284594	426	NA	FT		NUCLEUS		RNA endoribonuclease involved in perinuclear mRNP quality control via the turnover of aberrant, unprocessed pre-mRNAs; interacts with subunits of THO/TREX, TREX-2, and RNA polymerase II; contains a PIN (PilT N terminus) domain	nuclear mRNA surveillance of mRNP export|transcription, DNA-dependent	endoribonuclease activity	nucleus|cytoplasm
YDL129W	YDL129W	YDL129W	hom	Verified	1.07275203044926	0.141691194370345	no	710	0.102367383156747	343	NA	FT		NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YDL129W is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YCL012C	YCL012C	YCL012C	hom	Verified	1.06972782966891	0.142370917912507	no	711	0.125583551079945	434	NA					Putative protein of unknown function; orthologs are present in S. bayanus, S. paradoxus and Ashbya gossypii; YCL012C is not an essential gene	biological_process	molecular_function	cellular_component
YOR303W	YOR303W	CPA1	hom	Verified	1.06891323076847	0.142554384784663	no	712	0.124460085758055	397	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Small subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader	arginine biosynthetic process	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	carbamoyl-phosphate synthase complex
YBR043C	YBR043C	QDR3	hom	Verified	1.06799047028433	0.14276240525648	no	713	0.120916469000633	454	NA	FT		PLASMA MEMBRANE		Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; has a role in polyamine homeostasis; expression is upregulated under polyamine stress; required for resistance to quinidine, barban, cisplatin, and bleomycin	drug transmembrane transport|polyamine homeostasis	drug transmembrane transporter activity|polyamine transmembrane transporter activity	integral to membrane|plasma membrane
YHR082C	YHR082C	KSP1	hom	Verified	1.06760954915532	0.142848337178684	no	714	0.147051899615025	526	NA	FT	PROTEIN LOCALIZATION|SIGNALING|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Serine/threonine protein kinase; associates with TORC1 and likely involved in TOR signaling cascades; negative regulator of autophagy; nuclear translocation required for haploid filamentous growth; regulates filamentous growth induced nuclear translocation of Bcy1p, Fus3p, and Sks1p; overproduction causes allele-specific suppression of prp20-10; protein abundance increases in response to DNA replication stress	TOR signaling cascade|protein phosphorylation|Unknown|cellular protein localization|regulation of filamentous growth|negative regulation of macroautophagy	protein serine/threonine kinase activity|protein kinase activity	nucleus|cytoplasm
YDR209C_d	YDR209C	YDR209C	hom	Dubious	1.06648716856618	0.143101738025215	no	715	0.128922877360466	460	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YDR210W.	Unknown	Unknown	Unknown
YCR048W	YCR048W	ARE1	hom	Verified	1.06543497675055	0.143339567917494	no	716	0.109319779770646	399	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the absence of oxygen; ARE1 has a paralog, ARE2, that arose from the whole genome duplication	sterol metabolic process	ergosterol O-acyltransferase activity|lanosterol O-acyltransferase activity	integral to membrane|endoplasmic reticulum
YOL060C	YOL060C	MAM3	hom	Verified	1.06382956419319	0.143702957901279	no	717	0.130726026507811	512	NA	FT	ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS			Protein required for normal mitochondrial morphology, has similarity to hemolysins	cellular manganese ion homeostasis|mitochondrion organization	molecular_function	fungal-type vacuole membrane|integral to membrane
YJL124C	YJL124C	LSM1	hom	Verified	1.06252209593471	0.143999366224007	no	718	0.177037565878711	614	NA	FF|FT	RNA PROCESSING	NUCLEUS		Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; forms cytoplasmic foci upon DNA replication stress	deadenylation-dependent decapping of nuclear-transcribed mRNA|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	RNA binding|RNA cap binding	mRNA cap binding complex|cytoplasmic mRNA processing body|cytoplasm
YOR285W	YOR285W	RDL1	hom	Verified	1.06177669422941	0.144168536215438	no	719	0.131658443241098	472	NA	FT		ENDOPLASMIC RETICULUM|MITOCHONDRION		Protein of unknown function containing a rhodanese-like domain; localized to the mitochondrial outer membrane; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion|endoplasmic reticulum
YOR040W	YOR040W	GLO4	hom	Verified	1.05942423202924	0.144703309359825	no	720	0.122383986713971	422	NA	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM	MITOCHONDRION		Mitochondrial glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate	cellular carbohydrate metabolic process|methylglyoxal catabolic process to D-lactate	hydroxyacylglutathione hydrolase activity	mitochondrion|mitochondrial matrix
YLR080W	YLR080W	EMP46	hom	Verified	1.05571823842995	0.145548481020552	no	721	0.121654844568921	398	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport	ER to Golgi vesicle-mediated transport	glycoprotein binding	ER to Golgi transport vesicle|Golgi membrane
YPL107W_p	YPL107W	YPL107W	hom	Uncharacterized	1.05564315029701	0.145565639511191	no	722	0.139931858186825	504	NA	FT		MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YPL107W is not an essential gene	biological_process	molecular_function	mitochondrion
YDR312W	YDR312W	SSF2	hom	Verified	1.05522656076159	0.145660859654614	no	723	0.111149790654475	407	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS	NUCLEUS		Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication	conjugation with cellular fusion|ribosomal large subunit assembly	rRNA binding	nucleolus
YPL099C	YPL099C	AIM43	hom	Verified	1.0509854886012	0.146632627353686	no	724	0.130815063785946	438	NA	FT		MITOCHONDRION		Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	mitochondrion
YMR276W	YMR276W	DSK2	hom	Verified	1.05069565578686	0.146699195938552	no	725	0.132929145396012	487	NA	FT	CELL CYCLE|PROTEOLYSIS|CYTOSKELETON ORGANIZATION	NUCLEUS		Nuclear-enriched ubiquitin-like polyubiquitin-binding protein; required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle; involved in proteolysis; interacts with the proteasome; protein abundance increases in response to DNA replication stress	ER-associated protein catabolic process|spindle pole body duplication associated with nuclear envelope	protein binding, bridging	nucleus
YOR197W	YOR197W	MCA1	hom	Verified	1.05054572527662	0.146733639823304	no	726	0.127357527085628	460	NA	FT	PROTEOLYSIS	NUCLEUS		Ca2+-dependent cysteine protease; may cleave specific substrates during the stress response; regulates apoptosis upon H2O2 treatment; required for clearance of insoluble protein aggregates during normal growth; implicated in cell cycle dynamics; undergoes autocatalytic processing; similar to mammalian metacaspases, but exists as a monomer due to an extra pair of anti-parallel beta-strands that form a continuous beta-sheet, blocking potential dimerization	misfolded or incompletely synthesized protein catabolic process|apoptotic process	cysteine-type peptidase activity	nucleus
YPL105C	YPL105C	SYH1	hom	Verified	1.0503840454313	0.146770788990206	no	727	0.142258180764888	551	NA	FT	PROTEIN LOCALIZATION	MITOCHONDRION		Protein of unknown function that influences nuclear pore distribution; co-purifies with ribosomes; contains a GYF domain, which bind proline-rich sequences; deletion extends chronological lifespan; SYH1 has a paralog, SMY2, that arose from the whole genome duplication	nuclear pore distribution	molecular_function	mitochondrion|ribosome|cytoplasmic mRNA processing body|extrinsic to membrane|cytoplasm
YBR208C	YBR208C	DUR1,2	hom	Verified	1.05032380912869	0.14678463109452	no	728	0.132024366922166	491	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Urea amidolyase; contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; protein abundance increases in response to DNA replication stress	allantoin catabolic process|urea catabolic process	urea carboxylase activity|allophanate hydrolase activity	cytoplasm
YMR174C	YMR174C	PAI3	hom	Verified	1.0487377078131	0.147149427116071	no	729	0.135705051599197	482	NA					Cytoplasmic proteinase A (Pep4p) inhibitor, dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact	vacuolar protein catabolic process	endopeptidase inhibitor activity	cytoplasm
YPL123C	YPL123C	RNY1	hom	Verified	1.04756063281524	0.147420541538733	no	730	0.122482430263589	438	NA					Vacuolar RNase of the T(2) family, relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; promotes apoptosis under stress conditions and this function is independent of its catalytic activity	cell morphogenesis|RNA catabolic process|apoptotic process	endoribonuclease activity	cytosol|extracellular region|vacuole
YDL041W_d	YDL041W	YDL041W	hom	Dubious	1.04732082539218	0.147475817141074	no	731	0.184551456673018	674	NA	FF				Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIR2/YDL042C	Unknown	Unknown	Unknown
YDR070C	YDR070C	FMP16	hom	Verified	1.04716393438292	0.147511988026365	no	732	0.130766316704943	491	NA	FT		MITOCHONDRION		Protein of unknown function; may be involved in responding to conditions of stress; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	mitochondrion
YNR049C	YNR049C	MSO1	hom	Verified	1.04595380875387	0.147791179601564	no	733	0.146036601907581	502	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Probable component of the secretory vesicle docking complex; acts at a late step in secretion; shows genetic and physical interactions with Sec1p; required for prospore membrane formation during sporulation; relocalizes from bud neck to nucleus upon DNA replication stress	cellular membrane fusion|ascospore-type prospore membrane assembly|vesicle docking involved in exocytosis	molecular_function	SNARE complex|cellular bud membrane|plasma membrane|prospore membrane|cellular bud neck|cellular bud tip
YJL093C	YJL093C	TOK1	hom	Verified	1.04518683656123	0.147968313044829	no	734	0.149241911640252	517	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Outward-rectifier potassium channel of the plasma membrane with two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin	cellular potassium ion homeostasis	potassium channel activity	integral to membrane|plasma membrane
YNL076W	YNL076W	MKS1	hom	Verified	1.04500004058336	0.148011475382985	no	735	0.135546652903565	480	NA	FT	TRANSCRIPTION FROM RNA POL II|SIGNALING	NUCLEUS		Pleiotropic negative transcriptional regulator involved in Ras-CAMP and lysine biosynthetic pathways and nitrogen regulation; involved in retrograde (RTG) mitochondria-to-nucleus signaling	regulation of nitrogen utilization|negative regulation of transcription from RNA polymerase II promoter|Unknown|mitochondria-nucleus signaling pathway	molecular_function	cytoplasm
YNL012W	YNL012W	SPO1	hom	Verified	1.04380585378899	0.148287611366991	no	736	0.126091323878556	466	NA	FT	CELL CYCLE|LIPID METABOLISM|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Meiosis-specific prospore protein; required for meiotic spindle pole body duplication and separation; required to produce bending force necessary for proper prospore membrane assembly during sporulation; has similarity to phospholipase B	meiosis|spore membrane bending pathway	phospholipase activity	endoplasmic reticulum|nucleus|prospore membrane
YDR423C	YDR423C	CAD1	hom	Verified	1.04270436977143	0.148542616713992	no	737	0.154719307742483	544	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		AP-1-like basic leucine zipper (bZIP) transcriptional activator; involved in stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins; binds consensus sequence TTACTAA; CAD1 has a paralog, YAP1, that arose from the whole genome duplication	cellular response to cadmium ion|positive regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|cytoplasm
YDL094C_d	YDL094C	YDL094C	hom	Dubious	1.04203462326555	0.148697813465439	no	738	0.127785508938934	513	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verfied gene PMT5/YDL093W; YDL094C is not essential	Unknown	Unknown	Unknown
YDR307W_p	YDR307W	PMT7	hom	Uncharacterized	1.04089994171439	0.148960994394795	no	739	0.14125944000706	490	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative protein mannosyltransferase similar to Pmt1p; has a potential role in protein O-glycosylation	biological_process	molecular_function	integral to membrane|endoplasmic reticulum
YPR028W	YPR028W	YOP1	hom	Verified	1.03860251733608	0.149494817282986	no	740	0.150477882497878	565	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Membrane protein that interacts with Yip1p to mediate membrane traffic; interacts with Sey1p to maintain ER morphology; overexpression leads to cell death and accumulation of internal cell membranes; mutants have reduced phosphatidylserine transfer between the ER and mitochondria; forms ER foci upon DNA replication stress	vesicle-mediated transport|endoplasmic reticulum organization|endoplasmic reticulum inheritance|nuclear pore complex assembly	protein binding	integral to membrane|endoplasmic reticulum|endoplasmic reticulum tubular network
YGR109C	YGR109C	CLB6	hom	Verified	1.03821697488599	0.149584525769162	no	741	0.139656531241597	496	NA	FT	CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION	NUCLEUS		B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1	regulation of cyclin-dependent protein kinase activity|G1/S transition of mitotic cell cycle|regulation of S phase of mitotic cell cycle|premeiotic DNA replication	cyclin-dependent protein kinase regulator activity	cellular_component
YMR012W	YMR012W	CLU1	hom	Verified	1.03547631336156	0.150223261378011	no	742	0.138047950708851	486	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION			eIF3 component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation, can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant	translational initiation|mitochondrion organization	molecular_function	eukaryotic translation initiation factor 3 complex|cytoplasm
YDR104C	YDR104C	SPO71	hom	Verified	1.03496424606656	0.150342804481592	no	743	0.114323101462145	417	NA	FT	CELL WALL ORG/BIOGENESIS			Meiosis-specific protein of unknown function, required for spore wall formation during sporulation, in particular for the proper size of the prospore membrane (PSM); interacts with SPO1; dispensable for both nuclear divisions during meiosis; contains two PH domains	ascospore wall assembly	molecular_function	ascospore wall
YBL103C	YBL103C	RTG3	hom	Verified	1.03476612299401	0.150389073699868	no	744	0.141902988332728	489	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|SIGNALING	NUCLEUS		Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways	mitochondrion degradation|cellular response to oleic acid|mitochondria-nucleus signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription factor import into nucleus	RNA polymerase II transcription factor binding|sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity	nucleus|cytoplasm
YLR344W	YLR344W	RPL26A	hom	Verified	1.03471409240025	0.150401226380927	no	745	0.136345836005874	472	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L26A; binds to 5.8S rRNA; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26A has a paralog, RPL26B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YPR111W	YPR111W	DBF20	hom	Verified	1.03467039570185	0.150411433036295	no	746	0.121630956387402	439	NA	FT	CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Ser/Thr kinase involved in late nuclear division, one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs	cytokinesis after mitosis|protein phosphorylation|barrier septum assembly involved in cell cycle cytokinesis|regulation of mRNA catabolic process|exit from mitosis	protein serine/threonine kinase activity	spindle pole body|cellular bud neck|cytoplasm
YPL068C_p	YPL068C	YPL068C	hom	Uncharacterized	1.03455441924982	0.150438525002142	no	747	0.154994934704379	529	NA	FT		NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	nucleus
YOL035C_d	YOL035C	YOL035C	hom	Dubious	1.03374429880244	0.150627858870786	no	748	0.142349065751234	488	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR055W	YDR055W	PST1	hom	Verified	1.031408265437	0.151174703226158	no	749	0.150522495489177	485	NA	FT	CELL WALL ORG/BIOGENESIS	PLASMA MEMBRANE		Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1	fungal-type cell wall organization	molecular_function	fungal-type cell wall|plasma membrane
YJR124C_p	YJR124C	YJR124C	hom	Uncharacterized	1.03089560630992	0.151294888615851	no	750	0.123204261619031	468	NA					Putative protein of unknown function; expression induced under calcium shortage	biological_process	molecular_function	integral to membrane
YDR476C_p	YDR476C	YDR476C	hom	Uncharacterized	1.02932173230874	0.151664257161208	no	751	0.137606499262204	482	NA	FT		ENDOPLASMIC RETICULUM		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR476C is not an essential gene	biological_process	molecular_function	endoplasmic reticulum
YDR085C	YDR085C	AFR1	hom	Verified	1.02861172316653	0.151831083444454	no	752	0.14564730414758	519	NA	FT	SIGNALING			Protein required for pheromone-induced projection (shmoo) formation; regulates septin architecture during mating; has an RVXF motif that mediates targeting of Glc7p to mating projections; interacts with Cdc12p; AFR1 has a paralog, YER158C, that arose from the whole genome duplication	regulation of G-protein coupled receptor protein signaling pathway|pheromone-dependent signal transduction involved in conjugation with cellular fusion|cell morphogenesis involved in conjugation with cellular fusion|cell morphogenesis involved in conjugation	receptor signaling protein activity	mating projection base
YGL081W_p	YGL081W	YGL081W	hom	Uncharacterized	1.02775452469002	0.152032656260627	no	753	0.11688560726207	382	NA					Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis	biological_process	molecular_function	cellular_component
YDR400W	YDR400W	URH1	hom	Verified	1.02559303753718	0.152541725333975	no	754	0.138302857310803	461	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	NUCLEUS		Uridine nucleosidase (uridine-cytidine N-ribohydrolase), cleaves N-glycosidic bonds in nucleosides; involved in the pyrimidine salvage and nicotinamide riboside salvage pathways	pyrimidine-containing compound salvage|NAD biosynthesis via nicotinamide riboside salvage pathway|pyrimidine nucleoside catabolic process|nicotinate nucleotide salvage	ribosylpyrimidine nucleosidase activity|nicotinic acid riboside hydrolase activity|nicotinamide riboside hydrolase activity|uridine nucleosidase activity	nucleus|cytoplasm
YHR180W_d	YHR180W	YHR180W	hom	Dubious	1.02462455579572	0.152770186690176	no	755	0.138793913879841	500	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPL121C	YPL121C	MEI5	hom	Verified	1.02308368674984	0.15313413967346	no	756	0.123485677855033	417	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Sae3p; proposed to be an assembly factor for Dmc1p	meiotic DNA recombinase assembly|reciprocal meiotic recombination	molecular_function	condensed nuclear chromosome
YPL130W	YPL130W	SPO19	hom	Verified	1.02193299361361	0.153406307689979	no	757	0.125697210167044	432	NA	FT	CELL CYCLE|MEMBRANE ORGANIZATION			Meiosis-specific prospore protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation; identified as a weak high-copy suppressor of the spo1-1 ts mutation	meiosis|spore membrane bending pathway	molecular_function	fungal-type cell wall|prospore membrane
YMR052W	YMR052W	FAR3	hom	Verified	1.02182984360156	0.153430720915288	no	758	0.171510851536137	634	NA	FT	CELL CYCLE|SIGNALING	ENDOPLASMIC RETICULUM		Protein of unknown function; involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress	re-entry into mitotic cell cycle after pheromone arrest	molecular_function	endoplasmic reticulum
YDR428C	YDR428C	BNA7	hom	Verified	1.02181047090163	0.153435306272929	no	759	0.13014266793415	463	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			Formylkynurenine formamidase, involved in the de novo biosynthesis of NAD from tryptophan via kynurenine	NAD biosynthetic process	arylformamidase activity	cellular_component
YKL087C	YKL087C	CYT2	hom	Verified	1.02090132890642	0.153650594737272	no	760	0.153950280973136	527	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS	MITOCHONDRION		Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1	cytochrome c-heme linkage	holocytochrome-c synthase activity	mitochondrion|mitochondrial intermembrane space
YOR008C-A_p	YOR008C-A	YOR008C-A	hom	Uncharacterized	1.01641325065676	0.1547163191469	no	761	0.137818693144564	453	NA					Putative protein of unknown function, includes a potential transmembrane domain; deletion results in slightly lengthened telomeres	biological_process	molecular_function	cellular_component
YGL226C-A	YGL226C-A	OST5	hom	Verified	1.01607777931485	0.154796174788714	no	762	0.151373789526943	546	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Zeta subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins	protein N-linked glycosylation	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	oligosaccharyltransferase complex
YHL035C	YHL035C	VMR1	hom	Verified	1.01593512757235	0.154830139877711	no	763	0.161762674961756	569	NA	FT	NUCLEOTIDE METABOLISM	MITOCHONDRION		Vacuolar membrane protein involved in multiple drug resistance and metal sensitivity; ATP-binding cassette (ABC) family member involved in drug transport; potential Cdc28p substrate; induced under respiratory conditions	transport|response to drug|response to metal ion|drug transport	ATPase activity, coupled to transmembrane movement of substances	fungal-type vacuole membrane|mitochondrion|integral to membrane|ribosome
YNL043C_d	YNL043C	YNL043C	hom	Dubious	1.01545847354755	0.154943665934363	no	764	0.159092842631547	565	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W	Unknown	Unknown	Unknown
YBR101C	YBR101C	FES1	hom	Verified	1.01438714167213	0.155199028717305	no	765	0.15378547051819	551	NA	FT	TRANSLATION		RIBOSOME	Hsp70 (Ssa1p) nucleotide exchange factor; cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum; protein abundance increases in response to DNA replication stress	cytoplasmic translation	adenyl-nucleotide exchange factor activity	cytosol|cytosolic ribosome
YGR184C	YGR184C	UBR1	hom	Verified	1.01359880999792	0.155387112872683	no	766	0.170319366364969	570	NA	FT	PROTEOLYSIS			E3 ubiquitin ligase (N-recognin); forms heterodimer with Rad6p to ubiquitinate substrates in the N-end rule pathway; regulates peptide transport via Cup9p ubiquitination; plays a major role in targeting cytosolic misfolded proteins for degradation; mutation in human UBR1 causes Johansson-Blizzard Syndrome (JBS)	regulation of dipeptide transport|ubiquitin-dependent protein catabolic process via the N-end rule pathway|cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process|protein polyubiquitination	ubiquitin-protein ligase activity	proteasome regulatory particle, base subcomplex|cytoplasm
YDR116C	YDR116C	MRPL1	hom	Verified	1.01208882791944	0.155747791823468	no	767	0.147243171347572	521	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YNL071W	YNL071W	LAT1	hom	Verified	1.01139064635935	0.155914748107034	no	768	0.17486898834281	599	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA	acetyl-CoA biosynthetic process from pyruvate	dihydrolipoyllysine-residue acetyltransferase activity	mitochondrion|mitochondrial pyruvate dehydrogenase complex
YDR142C	YDR142C	PEX7	hom	Verified	1.01112394584217	0.155978555379846	no	769	0.175184746226515	568	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PEROXISOME ORGANIZATION			Peroxisomal signal receptor for the N-terminal nonapeptide signal (PTS2) of peroxisomal matrix proteins; WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodysplasia punctata (RCDP)	protein import into peroxisome matrix, docking	peroxisome matrix targeting signal-2 binding	cytosol|peroxisome
YGR228W_d	YGR228W	YGR228W	hom	Dubious	1.00973282440993	0.156311655862571	no	770	0.187429054931439	688	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SMI1/YGR229C	Unknown	Unknown	Unknown
YGL186C	YGL186C	TPN1	hom	Verified	1.0085957523559	0.156584272636668	no	771	0.282911278865582	992	NA	FF|FT		PLASMA MEMBRANE		Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p	vitamin transport	vitamin transporter activity	integral to membrane|plasma membrane
YCR026C	YCR026C	NPP1	hom	Verified	1.00798120031261	0.156731743741746	no	772	0.181000621389512	673	NA	FT	NUCLEOTIDE METABOLISM|RESPONSE TO NUTRIENT LEVELS			Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; NPP1 has a paralog, NPP2, that arose from the whole genome duplication	cellular response to phosphate starvation|phosphate-containing compound metabolic process|nucleoside triphosphate metabolic process	nucleotide diphosphatase activity|nucleoside-triphosphate diphosphatase activity|nucleoside-triphosphatase activity|phosphodiesterase I activity	cellular_component
YMR068W	YMR068W	AVO2	hom	Verified	1.00750268690784	0.156846633584379	no	773	0.166050990745037	576	NA	FT	SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	PLASMA MEMBRANE		Component of a complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth	fungal-type cell wall organization|TOR signaling cascade|regulation of cell growth|establishment or maintenance of actin cytoskeleton polarity	molecular_function	TORC2 complex|cytoplasm
YPR185W	YPR185W	ATG13	hom	Verified	1.00555472801024	0.157314905354886	no	774	0.143375785825327	515	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Regulatory subunit of the Atg1p signaling complex; stimulates Atg1p kinase activity; required for vesicle formation during autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; involved in Atg9p, Atg23p, and Atg27p cycling	piecemeal microautophagy of nucleus|mitochondrion degradation|macroautophagy|activation of protein kinase activity|CVT pathway	protein kinase regulator activity	Atg1p signaling complex|extrinsic to membrane
YKR050W	YKR050W	TRK2	hom	Verified	1.00533212728952	0.157368475016879	no	775	0.171128388551434	561	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Component of the Trk1p-Trk2p potassium transport system; TRK2 has a paralog, TRK1, that arose from the whole genome duplication	cellular potassium ion homeostasis	potassium ion transmembrane transporter activity	integral to membrane|plasma membrane
YGR151C_d	YGR151C	YGR151C	hom	Dubious	1.00480030407397	0.157496508721997	no	776	0.15642497823277	563	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF RSR1/BUD1/YGR152C; relative distribution to the nucleus increases upon DNA replication stress	Unknown	Unknown	Unknown
YNL022C_p	YNL022C	YNL022C	hom	Uncharacterized	1.00405798718744	0.157675332123576	no	777	0.142563705382378	532	NA	FT		NUCLEUS		Putative cytosine 5-methyltransferase, contains seven beta-strand methyltransferase motif similar to NOP2/YNL061W; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; predicted to be involved in ribosome biogenesis	biological_process	tRNA (cytosine-5-)-methyltransferase activity	nucleus
YGL208W	YGL208W	SIP2	hom	Verified	1.00398157451806	0.157693747428692	no	778	0.144401953009358	538	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|SIGNALING|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS	PLASMA MEMBRANE		One of three beta subunits of the Snf1 serine/threonine protein kinase complex involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and the plasma membrane	cellular response to glucose starvation|signal transduction|protein phosphorylation|replicative cell aging|invasive growth in response to glucose limitation|regulation of protein complex assembly	AMP-activated protein kinase activity	AMP-activated protein kinase complex|plasma membrane|cytoplasm
YER038W-A_d	YER038W-A	YER038W-A	hom	Dubious	1.00215559201142	0.158134225938043	no	779	0.164342058007116	537	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 99% of ORF overlaps the verified gene HVG1; protein product detected in mitochondria	Unknown	Unknown	Unknown
YDL037C	YDL037C	BSC1	hom	Verified	1.00142306260773	0.158311159449472	no	780	0.16105601391301	566	NA					Protein of unconfirmed function, similar to cell surface flocculin Flo11p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression	biological_process	molecular_function	cellular_component
YDR225W	YDR225W	HTA1	hom	Verified	0.999579845342148	0.158756940415965	no	781	0.166292734857229	615	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME	RSC COMPLEX	Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p	DNA repair|chromatin assembly or disassembly|negative regulation of transcription from RNA polymerase II promoter	DNA binding	replication fork protection complex|nuclear nucleosome
YPR039W_d	YPR039W	YPR039W	hom	Dubious	0.998371522062901	0.159049618763588	no	782	0.182363689883266	650	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified non essential genes ERV2/YPR037C and TIP41/YPR040W	Unknown	Unknown	Unknown
YER103W	YER103W	SSA4	hom	Verified	0.991915481696305	0.160619378131579	no	783	0.144008300499962	524	NA	FT	PROTEIN LOCALIZATION	NUCLEUS		Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation; SSA4 has a paralog, SSA3, that arose from the whole genome duplication	protein folding|SRP-dependent cotranslational protein targeting to membrane, translocation|response to stress	unfolded protein binding|ATPase activity	nucleus|cytoplasm
YOL004W	YOL004W	SIN3	hom	Verified	0.991914233311736	0.160619682646344	no	784	0.161335979313392	603	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CELL DIVISION|GENE SILENCING	NUCLEUS|CHROMOSOME		Component of the Sin3p-Rpd3p histone deacetylase complex, involved in transcriptional repression and activation of diverse processes, including mating-type switching and meiosis; involved in the maintenance of chromosomal integrity	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of chromatin silencing at rDNA|histone deacetylation|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of transcription from RNA polymerase I promoter|negative regulation of transcription during meiosis|regulation of DNA-dependent DNA replication initiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of chromatin silencing at telomere|double-strand break repair via nonhomologous end joining|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription involved in G2/M-phase of mitotic cell cycle	transcription coactivator activity|transcription corepressor activity	Sin3-type complex|Rpd3S complex|Rpd3L-Expanded complex|Rpd3L complex
YGL035C	YGL035C	MIG1	hom	Verified	0.98786613819073	0.161609105574278	no	785	0.181069265648718	621	NA	FT	TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS	ENDOMEMBRANE SYSTEM|NUCLEUS		Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion	negative regulation of transcription from RNA polymerase II promoter by glucose|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding	nucleus|nuclear envelope lumen|cytoplasm
YIR002C	YIR002C	MPH1	hom	Verified	0.985687022022035	0.162143359957414	no	786	0.165853747694633	590	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		3'-5' DNA helicase involved in error-free bypass of DNA lesions; binds to flap DNA in an error-free bypass pathway and stimulates the activity of Rad27p and Dna2p; also involved in interstrand cross-link repair mutations confer a mutator phenotype; similarity to FANCM, a human Fanconi anemia complementation group protein that along with the MHF complex is involved in stabilizing and remodeling blocked replication forks; member of the SF2 DExD/H superfamily of helicases	negative regulation of strand invasion|recombinational repair|DNA replication, Okazaki fragment processing	flap-structured DNA binding|3'-5' DNA helicase activity	nucleus
YDL239C	YDL239C	ADY3	hom	Verified	0.98452039661003	0.162429853902861	no	787	0.153453985492798	471	NA	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|MITOCHONDRION ORGANIZATION	NUCLEUS|CYTOSKELETON		Protein required for spore wall formation; thought to mediate assembly of a Don1p-containing structure at the leading edge of the prospore membrane via interaction with spindle pole body components; potentially phosphorylated by Cdc28p; ADY3 has a paralog, CNM67, that arose from the whole genome duplication	mitochondrion inheritance|ascospore wall assembly|sporulation resulting in formation of a cellular spore	molecular_function	spindle pole body|prospore membrane
YGL110C	YGL110C	CUE3	hom	Verified	0.98348061525586	0.162685475624335	no	788	0.135786149840188	492	NA					Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination	biological_process	ubiquitin binding	cytoplasm
YBL029C-A	YBL029C-A	YBL029C-A	hom	Verified	0.9788831872995	0.16381885013979	no	789	0.166058514007697	545	NA	FT		PLASMA MEMBRANE		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; protein abundance increases in response to DNA replication stress; has potential orthologs in Saccharomyces species and in Yarrowia lipolytica	biological_process	molecular_function	plasma membrane
YKL185W	YKL185W	ASH1	hom	Verified	0.977510209279502	0.164158312974395	no	790	0.121219988888393	447	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate	Unknown	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|core promoter proximal region sequence-specific DNA binding	Rpd3L-Expanded complex|nucleus|cellular bud|Rpd3L complex
YOL136C	YOL136C	PFK27	hom	Verified	0.975516060115547	0.164652169609191	no	791	0.150806590339214	542	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			6-phosphofructo-2-kinase, catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A	regulation of glycolysis|fructose 2,6-bisphosphate metabolic process	6-phosphofructo-2-kinase activity	cytoplasm
YOR288C	YOR288C	MPD1	hom	Verified	0.975238112971452	0.164721080360125	no	792	0.144128703286135	501	NA	FT		ENDOPLASMIC RETICULUM		Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation	protein folding	protein disulfide oxidoreductase activity|protein disulfide isomerase activity	fungal-type vacuole
YGL079W_p	YGL079W	KXD1	hom	Uncharacterized	0.974997935773588	0.164780641947628	no	793	0.15009337897716	508	NA					Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; GFP-fusion protein localizes to the endosome	biological_process	molecular_function	endosome
YMR141C_d	YMR141C	YMR141C	hom	Dubious	0.974976314347282	0.16478600453352	no	794	0.168396914562101	564	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPL100W	YPL100W	ATG21	hom	Verified	0.973759098934785	0.165088082856087	no	795	0.171076289866929	593	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Phosphoinositide binding protein required for vesicle formation in the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein	piecemeal microautophagy of nucleus|vesicle organization|mitochondrion degradation|macroautophagy|protein localization to pre-autophagosomal structure|CVT pathway|protein lipidation	phosphatidylinositol binding	endosome|cytosol|fungal-type vacuole membrane
YBR084W	YBR084W	MIS1	hom	Verified	0.973332384572247	0.165194066063396	no	796	0.140845227225144	501	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase	nucleobase-containing compound metabolic process|folic acid biosynthetic process	formate-tetrahydrofolate ligase activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|methenyltetrahydrofolate cyclohydrolase activity	mitochondrion
YPR009W	YPR009W	SUT2	hom	Verified	0.972060347740783	0.165510263573981	no	797	0.179955232933512	573	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1p	positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II repressing transcription factor binding|sequence-specific DNA binding	nucleus
YNL084C	YNL084C	END3	hom	Verified	0.97147608823648	0.165655627433047	no	798	0.204246097761852	725	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON		EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p	bipolar cellular bud site selection|ascospore wall assembly|endocytosis|actin filament organization|cytokinesis|actin cortical patch assembly	protein binding, bridging	mating projection tip|actin cortical patch
YER097W_d	YER097W	YER097W	hom	Dubious	0.969978330499299	0.166028646759079	no	799	0.205387353323168	693	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOL062C	YOL062C	APM4	hom	Verified	0.969283962989977	0.166201764259633	no	800	0.144190567159654	550	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|PLASMA MEMBRANE		Mu2-like subunit of the clathrin associated protein complex (AP-2); involved in vesicle transport	intracellular protein transport|vesicle-mediated transport	molecular_function	AP-2 adaptor complex
YPL133C	YPL133C	RDS2	hom	Verified	0.968627025835414	0.16636565704223	no	801	0.13501165499039	463	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|SIGNALING|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Transcription factor involved in regulating gluconeogenesis and glyoxylate cycle genes; member of the zinc cluster family of proteins; confers resistance to ketoconazole	positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source|positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter|cellular response to xenobiotic stimulus|positive regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|cytoplasm
YKR077W	YKR077W	MSA2	hom	Verified	0.967597463072316	0.166622722382363	no	802	0.163488523828812	606	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE	NUCLEUS		Putative transcriptional activator, that interacts with G1-specific transcription factor, MBF and G1-specific promoters; ortholog of Msa2p, an MBF and SBF activator that regulates G1-specific transcription and cell cycle initiation	regulation of transcription involved in G1 phase of mitotic cell cycle	molecular_function	nucleus|cytoplasm
YML006C	YML006C	GIS4	hom	Verified	0.967565964190346	0.166630591188341	no	803	0.175533328368839	588	NA	FT	SIGNALING|ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		CAAX box containing protein of unknown function, proposed to be involved in the RAS/cAMP signaling pathway	cellular ion homeostasis|intracellular signal transduction	molecular_function	plasma membrane
YDR304C	YDR304C	CPR5	hom	Verified	0.966596862338101	0.1668728018745	no	804	0.156995459143172	590	NA	FT		ENDOPLASMIC RETICULUM		Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum, catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfolded proteins in the ER	biological_process	peptidyl-prolyl cis-trans isomerase activity	endoplasmic reticulum|cytoplasm
YJL150W_d	YJL150W	YJL150W	hom	Dubious	0.963346305327001	0.167686881357631	no	805	0.144529034233457	520	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YBR273C	YBR273C	UBX7	hom	Verified	0.963049971700408	0.167761223060863	no	806	0.143699119934709	529	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p; UBX7 has a paralog, UBX6, that arose from the whole genome duplication	sporulation resulting in formation of a cellular spore|ubiquitin-dependent protein catabolic process	molecular_function	nuclear envelope|endoplasmic reticulum
YBR086C	YBR086C	IST2	hom	Verified	0.962822969714311	0.167818185774672	no	807	0.181410481085515	606	NA	FT		PLASMA MEMBRANE		Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localizes to the mother cell in small-budded cells and to the bud in medium- and large-budded cells; mRNA is transported to the bud tip by an actomyosin-driven process	response to osmotic stress	lipid binding	integral to membrane|cellular bud membrane|plasma membrane
YOR035C	YOR035C	SHE4	hom	Verified	0.962758334009356	0.167834407404294	no	808	0.27067218510473	960	NA	FF|FT	CYTOSKELETON ORGANIZATION|RNA LOCALIZATION			Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization	mating type switching|intracellular mRNA localization|actin cytoskeleton organization	myosin binding	cytoplasm
YGL231C	YGL231C	EMC4	hom	Verified	0.962059746484213	0.168009796403596	no	809	0.191722317105314	652	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm ZK616.6/EMC-4, fly CG11137, human TMM85	protein folding in endoplasmic reticulum	molecular_function	ER membrane protein complex|endoplasmic reticulum
YIL132C	YIL132C	CSM2	hom	Verified	0.960903074610422	0.168300452362889	no	810	0.135311973593986	471	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS		Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function; structural analysis reveals a similar DNA-binding region in both Psy3p and Csm2p and that both regions work together to form a single DNA binding site; required for accurate chromosome segregation during meiosis	meiotic chromosome segregation|recombinational repair|maintenance of rDNA|error-free translesion synthesis	molecular_function	nucleus|Shu complex|cytoplasm
YNL004W	YNL004W	HRB1	hom	Verified	0.958809726134257	0.168827304272366	no	811	0.174266433302433	594	NA	FT	RNA LOCALIZATION	NUCLEUS		Poly(A+) RNA-binding protein; involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Npl3p; HRB1 has a paralog, GBP2, that arose from the whole genome duplication	poly(A)+ mRNA export from nucleus	RNA binding	integral to membrane|nucleus|cytoplasm
YKL140W	YKL140W	TGL1	hom	Verified	0.957908741537667	0.169054389049442	no	812	0.122513900221475	426	NA	FT	LIPID METABOLISM			Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes	cellular lipid metabolic process|sterol metabolic process	lipase activity|sterol esterase activity	integral to membrane|lipid particle
YOR219C	YOR219C	STE13	hom	Verified	0.957461417918457	0.169167205641746	no	813	0.176908863954827	579	NA	FT	PROTEOLYSIS	GOLGI APPARATUS		Dipeptidyl aminopeptidase, Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences, required for maturation of alpha factor, transcription is induced by a-factor	peptide pheromone maturation	aminopeptidase activity	trans-Golgi network
YPR097W	YPR097W	YPR097W	hom	Verified	0.957330011749641	0.169200355924335	no	814	0.187249049822835	651	NA	FT		MITOCHONDRION		Protein that contains a Phox homology (PX) domain and binds phosphoinositides; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	phosphatidylinositol binding	mitochondrion
YDL161W	YDL161W	ENT1	hom	Verified	0.955511786280767	0.169659473932009	no	815	0.142554977552799	503	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Epsin-like protein involved in endocytosis and actin patch assembly; functionally redundant with Ent2p; binds clathrin via a clathrin-binding domain motif at C-terminus; relocalizes from bud neck to cytoplasm upon DNA replication stress	actin filament organization|endocytosis|actin cortical patch assembly	clathrin binding	mating projection tip|actin cortical patch
YOL050C_d	YOL050C	YOL050C	hom	Dubious	0.955397998710717	0.169688232844831	no	816	0.188605061765643	649	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)	Unknown	Unknown	Unknown
YCR101C_p	YCR101C	YCR101C	hom	Uncharacterized	0.952201413386711	0.170497422176602	no	817	0.171578908183438	646	NA					Putative protein of unknown function; localizes to the membrane fraction; YCR101C is not an essential gene	biological_process	molecular_function	integral to membrane|membrane
YMR316C-B_d	YMR316C-B	YMR316C-B	hom	Dubious	0.950939031086906	0.170817663371367	no	818	0.127625638126809	498	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOR386W	YOR386W	PHR1	hom	Verified	0.949563065857564	0.171167156422924	no	819	0.187244324785984	652	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION		DNA photolyase involved in photoreactivation, repairs pyrimidine dimers in the presence of visible light; induced by DNA damage; regulated by transcriptional repressor Rph1p	photoreactive repair	mRNA binding|deoxyribodipyrimidine photo-lyase activity	mitochondrion|nucleus
YGR137W_d	YGR137W	YGR137W	hom	Dubious	0.94802726662391	0.171557786696657	no	820	0.163791463105118	561	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGL090W	YGL090W	LIF1	hom	Verified	0.947923699897057	0.171584149361987	no	821	0.173963858760758	636	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein	double-strand break repair via nonhomologous end joining	chromatin binding	DNA ligase IV complex|nuclear chromatin|nucleus
YCR015C_p	YCR015C	YCR015C	hom	Uncharacterized	0.947215165228842	0.171764574607495	no	822	0.156563351059057	547	NA					Putative protein of unknown function; YCR015C is not an essential gene	biological_process	molecular_function	cellular_component
YPR049C	YPR049C	ATG11	hom	Verified	0.946396360896422	0.171973230413332	no	823	0.186760520476614	641	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|PEROXISOME ORGANIZATION			Adapter protein for pexophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; directs receptor-bound cargo to the phagophore assembly site (PAS) for packaging into vesicles; required for recruiting other proteins to the (PAS)	piecemeal microautophagy of nucleus|mitochondrion degradation|peroxisome degradation|protein localization to pre-autophagosomal structure|CVT pathway	protein complex scaffold	pre-autophagosomal structure|extrinsic to membrane
YOR356W	YOR356W	CIR2	hom	Verified	0.946302963381078	0.171997041168295	no	824	0.167435815882481	599	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Putative ortholog of human electron transfer flavoprotein dehydrogenase (ETF-dH); found in a large supramolecular complex with other mitochondrial dehydrogenases; may have a role in oxidative stress response	biological_process	molecular_function	mitochondrion
YDL174C	YDL174C	DLD1	hom	Verified	0.944000419920775	0.172584716845489	no	825	0.144066544112568	512	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane	cellular carbohydrate metabolic process|aerobic respiration	D-lactate dehydrogenase (cytochrome) activity	mitochondrion|mitochondrial inner membrane
YBR068C	YBR068C	BAP2	hom	Verified	0.943964000235422	0.172594022476437	no	826	0.15887361176044	575	NA	FT		PLASMA MEMBRANE		High-affinity leucine permease; functions as a branched-chain amino acid permease involved in uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains; BAP2 has a paralog, BAP3, that arose from the whole genome duplication	amino acid transport|transmembrane transport	amino acid transmembrane transporter activity	integral to membrane|plasma membrane
YJL078C	YJL078C	PRY3	hom	Verified	0.943500192567426	0.172712558426259	no	827	0.136502447780645	497	NA					Cell wall-associated protein involved in export of acetylated sterols; member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); role in mating efficiency; expression of full-length transcript is daughter cell-specific; in response to alpha factor, a short transcript starting at +452 is expressed and the long form is repressed by Ste12p	biological_process	molecular_function	fungal-type cell wall
YDR223W	YDR223W	CRF1	hom	Verified	0.941781794328447	0.173152183962838	no	828	0.17345567366011	573	NA	FT	TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS	NUCLEUS|CHROMOSOME		Transcriptional corepressor involved in repression of ribosomal protein (RP) gene transcription via the TOR signaling pathway which promotes accumulation of Crf1p in the nucleus; role in repression of RP genes varies by strain	negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter	transcription corepressor activity	nuclear chromatin|nucleus|cytoplasm
YGR039W_d	YGR039W	YGR039W	hom	Dubious	0.940897355864886	0.173378731387732	no	829	0.174106273641244	626	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the Autonomously Replicating Sequence ARS722	Unknown	Unknown	Unknown
YOR379C_d	YOR379C	YOR379C	hom	Dubious	0.940413751472544	0.173502685598777	no	830	0.163361168435507	591	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR378W	Unknown	Unknown	Unknown
YBR274W	YBR274W	CHK1	hom	Verified	0.939710331318818	0.173683082154511	no	831	0.158627527685976	516	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION	NUCLEUS		Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase	protein phosphorylation|replication fork protection|DNA damage checkpoint	protein serine/threonine kinase activity	nucleus
YBR281C	YBR281C	DUG2	hom	Verified	0.936876447824355	0.174411057727315	no	832	0.167743308990667	617	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|PROTEOLYSIS	NUCLEUS		Component of glutamine amidotransferase (GATase II); forms a complex with Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)	glutathione catabolic process	peptidase activity|gamma-glutamyltransferase activity|omega peptidase activity	nucleus|cytoplasm
YHR025W	YHR025W	THR1	hom	Verified	0.934575481484814	0.175003559793474	no	833	0.198024574976706	667	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM			Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway	threonine biosynthetic process|methionine metabolic process|isoleucine metabolic process|homoserine metabolic process	homoserine kinase activity	cellular_component
YBL100W-C_p	YBL100W-C	YBL100W-C	hom	Uncharacterized	0.932144951950366	0.175630809812771	no	834	0.172357241571377	597	NA					Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YPR059C_d	YPR059C	YPR059C	hom	Dubious	0.932057944543177	0.175653290310528	no	835	0.189394009785673	699	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YMC1/YPR058W	Unknown	Unknown	Unknown
YKR009C	YKR009C	FOX2	hom	Verified	0.930885695188131	0.175956347427135	no	836	0.137013808633342	487	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS			Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities	fatty acid beta-oxidation	enoyl-CoA hydratase activity|3-hydroxyacyl-CoA dehydrogenase activity	peroxisome
YLR176C	YLR176C	RFX1	hom	Verified	0.930582805289287	0.176034706182808	no	837	0.168831500401305	593	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Major transcriptional repressor of DNA-damage-regulated genes, recruits repressors Tup1p and Cyc8p to their promoters; involved in DNA damage and replication checkpoint pathway; similar to a family of mammalian DNA binding RFX1-4 proteins	negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding	nucleus|cytoplasm
YDR281C	YDR281C	PHM6	hom	Verified	0.930474016773742	0.17606285557262	no	838	0.19802264248566	669	NA					Protein of unknown function, expression is regulated by phosphate levels	biological_process	molecular_function	fungal-type vacuole
YMR145C	YMR145C	NDE1	hom	Verified	0.927449044872242	0.176846718159645	no	839	0.174316555984022	572	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial external NADH dehydrogenase, a type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain	glucose catabolic process to ethanol|NADH oxidation|chronological cell aging	NADH dehydrogenase activity	mitochondrion
YDR415C_p	YDR415C	YDR415C	hom	Uncharacterized	0.927384017808981	0.176863592840033	no	840	0.147869787846208	510	NA	FT	PROTEOLYSIS			Putative aminopeptidase	biological_process	molecular_function	cellular_component
YGL149W_d	YGL149W	YGL149W	hom	Dubious	0.926531988751526	0.177084790463076	no	841	0.166809253020789	565	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF INO80/YGL150C.	Unknown	Unknown	Unknown
YGL101W_p	YGL101W	YGL101W	hom	Uncharacterized	0.925281633958386	0.177409714807999	no	842	0.179648248255124	541	NA	FT		NUCLEUS		Putative protein of unknown function; non-essential gene with similarity to YBR242W; interacts with the DNA helicase Hpr5p	biological_process	molecular_function	nucleus|cytoplasm
YER179W	YER179W	DMC1	hom	Verified	0.924344221386356	0.177653562906157	no	843	0.156611620741265	554	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Meiosis-specific protein required for repair of double-strand breaks and pairing between homologous chromosomes; homolog of Rad51p and the bacterial RecA protein; binds ssDNA and dsDNA, forms helical filaments; stimulated by Rdh54p	meiosis|reciprocal meiotic recombination|meiotic joint molecule formation	double-stranded DNA binding|single-stranded DNA binding	condensed nuclear chromosome|nucleus
YIR034C	YIR034C	LYS1	hom	Verified	0.923791990680246	0.177797313015088	no	844	0.196789350534399	633	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS			Saccharopine dehydrogenase (NAD+, L-lysine-forming), catalyzes the conversion of saccharopine to L-lysine, which is the final step in the lysine biosynthesis pathway; also has mRNA binding activity	lysine biosynthetic process|lysine biosynthetic process via aminoadipic acid	saccharopine dehydrogenase (NAD+, L-lysine-forming) activity|mRNA binding	cytoplasm
YKL137W	YKL137W	CMC1	hom	Verified	0.923644395148502	0.177835745745679	no	845	0.175291917886307	639	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Evolutionarily conserved copper-binding protein of the mitochondrial intermembrane space, may be involved in delivering copper from the matrix to the cytochrome c oxidase complex; contains a twin CX9C motif	mitochondrial respiratory chain complex IV assembly	copper ion binding	extrinsic to mitochondrial inner membrane|mitochondrial intermembrane space
YDR490C	YDR490C	PKH1	hom	Verified	0.923630339205875	0.177839406077273	no	846	0.161501223460171	582	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION			Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh2p	regulation of nuclear-transcribed mRNA poly(A) tail shortening|endocytosis|protein phosphorylation|MAPK cascade involved in cell wall biogenesis|cytoplasmic mRNA processing body assembly	protein kinase activity	cytosol|cell cortex|eisosome
YKR011C	YKR011C	YKR011C	hom	Verified	0.922760463609589	0.178066024307433	no	847	0.166309867245799	582	NA	FT		NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus
YLR294C_d	YLR294C	YLR294C	hom	Dubious	0.920954087050288	0.178537199152075	no	848	0.182797587508366	619	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ATP14	Unknown	Unknown	Unknown
YLR443W	YLR443W	ECM7	hom	Verified	0.918488195475889	0.179181668107952	no	849	0.179184400857432	669	NA	FT	ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS			Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency	fungal-type cell wall organization|calcium ion transport	molecular_function	integral to membrane
YNL143C_p	YNL143C	YNL143C	hom	Uncharacterized	0.918381635292387	0.179209550908994	no	850	0.198027047199622	632	NA					Protein of unknown function; expressed at both mRNA and protein levels	biological_process	molecular_function	cellular_component
YDR399W	YDR399W	HPT1	hom	Verified	0.915538753147539	0.179954433843088	no	851	0.16643056646218	594	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the transfer of the phosphoribosyl portion of 5-phosphoribosyl-alpha-1-pyrophosphate to a purine base (either guanine or hypoxanthine) to form pyrophosphate and a purine nucleotide (either guanosine monophosphate or inosine monophosphate); mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome	GMP salvage|IMP salvage	hypoxanthine phosphoribosyltransferase activity	nucleus|cytoplasm
YMR258C	YMR258C	ROY1	hom	Verified	0.913392744100776	0.180518010167575	no	852	0.186254672572238	674	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|NUCLEUS		GTPase inhibitor with similarity to F-box proteins; inhibits Ypt52p GTPase activity by preventing Ypt52p from binding GTP; involved in regulating intracellular trafficking; physically interacts with Skp1p	endocytosis|protein targeting to vacuole|negative regulation of GTPase activity	GTPase inhibitor activity	nucleus|cytoplasm
YMR306C-A_d	YMR306C-A	YMR306C-A	hom	Dubious	0.913220147306024	0.180563384897605	no	853	0.162627394413603	578	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPL015C	YPL015C	HST2	hom	Verified	0.91265816760821	0.180711175767961	no	854	0.201301598049785	629	NA	FT	GENE SILENCING	NUCLEUS		Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro; contains a nuclear export signal (NES); function regulated by its nuclear export	negative regulation of chromatin silencing at telomere|chronological cell aging|chromatin silencing at rDNA|negative regulation of mitotic recombination	NAD-dependent histone deacetylase activity	cytoplasm
YPR158W	YPR158W	CUR1	hom	Verified	0.912546109095979	0.1807406542714	no	855	0.199257463101012	708	NA	FT		NUCLEUS		Sorting factor, central regulator of spatial protein quality control; physically and functionally interacts with chaperones to promote sorting and deposition of misfolded proteins into cytosolic compartments; involved in destabilization of [URE3] prions; CUR1 has a paralog, BTN2, that arose from the whole genome duplication	cellular response to stress|protein localization to nucleus	chaperone binding	nucleus
YGR025W_d	YGR025W	YGR025W	hom	Dubious	0.911377413601779	0.181048275046188	no	856	0.148355293034206	476	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGR153W_p	YGR153W	YGR153W	hom	Uncharacterized	0.911323295754372	0.181062527737606	no	857	0.174735178256496	606	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YCL001W	YCL001W	RER1	hom	Verified	0.910594153025289	0.181254626199817	no	858	0.170721580946298	575	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Protein involved in retention of membrane proteins, including Sec12p, in the ER; localized to Golgi; functions as a retrieval receptor in returning membrane proteins to the ER	protein retention in ER lumen|retrograde vesicle-mediated transport, Golgi to ER|ER to Golgi vesicle-mediated transport	molecular_function	COPI-coated vesicle|integral to membrane|ER to Golgi transport vesicle
YMR322C_p	YMR322C	SNO4	hom	Uncharacterized	0.909382899348727	0.18157402264177	no	859	0.143785058540209	452	NA	FT	PROTEOLYSIS			Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation	biological_process	cysteine-type peptidase activity	cellular_component
YNL009W	YNL009W	IDP3	hom	Verified	0.909344422960413	0.181584174280009	no	860	0.175564123840423	587	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Peroxisomal NADP-dependent isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acids; IDP3 has a paralog, IDP2, that arose from the whole genome duplication	NADPH regeneration|fatty acid beta-oxidation|isocitrate metabolic process	isocitrate dehydrogenase (NADP+) activity	mitochondrion|peroxisome|cytoplasm
YOR325W_d	YOR325W	YOR325W	hom	Dubious	0.90834801945421	0.181847189798196	no	861	0.18453668202861	651	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF FRT1	Unknown	Unknown	Unknown
YDR477W	YDR477W	SNF1	hom	Verified	0.907148488284833	0.18216413981232	no	862	0.177538790715414	555	NA	FT	KETONE METABOLISM|SIGNALING|TRANSLATION|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS	ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION		AMP-activated serine/threonine protein kinase; found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; regulates filamentous growth in response to starvation	negative regulation of translation|protein phosphorylation|replicative cell aging|signal transduction|biofilm formation|positive regulation of gluconeogenesis|pseudohyphal growth|cell adhesion|regulation of carbohydrate metabolic process|invasive growth in response to glucose limitation|cellular response to nitrogen starvation	AMP-activated protein kinase activity|protein kinase activity	mitochondrion|AMP-activated protein kinase complex|nucleus|nuclear envelope lumen|fungal-type vacuole|cytoplasm
YNL231C	YNL231C	PDR16	hom	Verified	0.90583090229641	0.182512680932346	no	863	0.202826074696469	693	NA	FF|FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Phosphatidylinositol transfer protein (PITP); controlled by the multiple drug resistance regulator Pdr1p; localizes to lipid particles and microsomes; controls levels of various lipids, may regulate lipid synthesis; homologous to Pdr17p; protein abundance increases in response to DNA replication stress	response to drug|sterol biosynthetic process|phospholipid biosynthetic process|phospholipid transport	phosphatidylinositol transporter activity|phosphatidylcholine transporter activity	cell periphery|lipid particle|plasma membrane|cytoplasm
YMR022W	YMR022W	UBC7	hom	Verified	0.904258061959585	0.182929289496721	no	864	0.206303339184295	680	NA	FT	CHROMATIN ORGANIZATION|CELL WALL ORG/BIOGENESIS|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly	fungal-type cell wall organization|chromatin assembly or disassembly|ER-associated protein catabolic process	ubiquitin-protein ligase activity	endoplasmic reticulum membrane
YBL096C_d	YBL096C	YBL096C	hom	Dubious	0.902466954865325	0.183404433882292	no	865	0.165013422283613	598	NA					Non-essential protein of unknown function	Unknown	Unknown	Unknown
YOR121C_d	YOR121C	YOR121C	hom	Dubious	0.900390042327977	0.183956359053106	no	866	0.178162500052595	622	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GCY1/YOR120W	Unknown	Unknown	Unknown
YKL103C	YKL103C	APE1	hom	Verified	0.899757446898677	0.184124672193667	no	867	0.152674404793057	544	NA					Vacuolar aminopeptidase yscI; zinc metalloproteinase that belongs to the peptidase family M18; often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway; protein increases in abundance and relative distribution to cytoplasmic foci increases upon DNA replication stress	vacuolar protein catabolic process	metalloaminopeptidase activity	fungal-type vacuole
YGR209C	YGR209C	TRX2	hom	Verified	0.895412945254994	0.185283191555366	no	868	0.160735692291855	507	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS	ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS		Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p; required for ER-Golgi transport and vacuole inheritance; protein abundance increases in response to DNA replication stress	vacuole inheritance|regulation of DNA replication|cell redox homeostasis|protein deglutathionylation|sulfate assimilation|retrograde vesicle-mediated transport, Golgi to ER|cellular response to oxidative stress|ER to Golgi vesicle-mediated transport|vacuole fusion, non-autophagic	disulfide oxidoreductase activity	cytosol|fungal-type vacuole
YER019C-A	YER019C-A	SBH2	hom	Verified	0.892857857552699	0.185966648855628	no	869	0.18201845637209	617	NA	FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p	SRP-dependent cotranslational protein targeting to membrane	ARF guanyl-nucleotide exchange factor activity	Ssh1 translocon complex
YPR127W	YPR127W	YPR127W	hom	Verified	0.890142657147476	0.186694645248288	no	870	0.176846039705375	622	NA	FT	OXIDATION-REDUCTION PROCESS	NUCLEUS		Putative pyridoxine 4-dehydrogenase; differentially expressed during alcoholic fermentation; expression activated by transcription factor YRM1/YOR172W; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	biological_process	molecular_function	nucleus|cytoplasm
YKL067W	YKL067W	YNK1	hom	Verified	0.89004355185701	0.186721250574371	no	871	0.153416892323486	525	NA	FT	RESPONSE TO DNA DAMAGE|NUCLEOTIDE METABOLISM	MITOCHONDRION		Nucleoside diphosphate kinase; catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate; protein abundance increases in response to DNA replication stress	nucleoside diphosphate phosphorylation|nucleoside triphosphate biosynthetic process|response to DNA damage stimulus	nucleoside diphosphate kinase activity	cytosol|mitochondrion|mitochondrial intermembrane space
YNR073C_p	YNR073C	YNR073C	hom	Uncharacterized	0.888957779801736	0.187012885371255	no	872	0.219395476938224	684	NA					Putative mannitol dehydrogenase; identical in amino acid sequence to Dsf1p	biological_process	mannitol dehydrogenase activity	cellular_component
YDR465C	YDR465C	RMT2	hom	Verified	0.888286954335101	0.187193207634417	no	873	0.213474021226773	657	NA	FT		NUCLEUS		Arginine N5 methyltransferase; methylates ribosomal protein Rpl12 (L12) on Arg67; relative distribution to the nucleus increases upon DNA replication stress	peptidyl-arginine methylation	protein-arginine N5-methyltransferase activity	nucleus|cytoplasm
YKR064W	YKR064W	OAF3	hom	Verified	0.887294312846653	0.187460233335788	no	874	0.201652082094419	674	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS|MITOCHONDRION		Putative transcriptional repressor with Zn(2)-Cys(6) finger; negatively regulates transcription in response to oleate levels, based on mutant phenotype and localization to oleate-responsive promoters; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress	negative regulation of transcription from RNA polymerase II promoter|cellular response to oleic acid	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity	mitochondrion|nucleus|cytoplasm
YOL098C_p	YOL098C	YOL098C	hom	Uncharacterized	0.886930767416246	0.18755808780881	no	875	0.18965698803384	691	NA	FT	PROTEOLYSIS			Putative metalloprotease	biological_process	molecular_function	cytoplasm
YDR258C	YDR258C	HSP78	hom	Verified	0.885644446318122	0.18790457649004	no	876	0.165800740745844	562	NA	FT	PROTEIN LOCALIZATION|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; able to prevent the aggregation of misfolded proteins as well as resolubilize protein aggregates	positive regulation of mitochondrial translation in response to stress|protein refolding|protein stabilization|protein import into mitochondrial matrix|mitochondrial genome maintenance|protein unfolding|cellular response to heat	misfolded protein binding|ATPase activity	mitochondrion|mitochondrial matrix
YGR062C	YGR062C	COX18	hom	Verified	0.885072593003924	0.188058740051232	no	877	0.187608377574889	656	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial integral inner membrane protein required for membrane insertion of C-terminus of Cox2p; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC	protein insertion into mitochondrial membrane from inner side	membrane insertase activity	integral to membrane|integral to mitochondrial inner membrane
YBR094W	YBR094W	PBY1	hom	Verified	0.884806116902969	0.188130604895882	no	878	0.167954681735157	566	NA					Putative tubulin tyrosine ligase associated with P-bodies; forms cytoplasmic foci upon DNA replication stress	nuclear-transcribed mRNA catabolic process|biological_process	molecular_function	cytoplasmic mRNA processing body|cytoplasm
YNR072W	YNR072W	HXT17	hom	Verified	0.884048798219977	0.18833493557225	no	879	0.179427428829207	638	NA	FT		PLASMA MEMBRANE		Hexose transporter, up-regulated in media containing raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose	hexose transport	mannose transmembrane transporter activity|glucose transmembrane transporter activity|fructose transmembrane transporter activity	integral to membrane|plasma membrane
YDR282C_p	YDR282C	YDR282C	hom	Uncharacterized	0.883056046175034	0.188602995333741	no	880	0.159074583521994	553	NA					Putative protein of unknown function; localizes to the inner mitochondrial membrane with the C terminus facing the intermembrane space; ortholog of human RMND1, mutation in which is implicated in infantile encephaloneuromyopathy and defective mitochondrial translation	biological_process	molecular_function	cellular_component
YNL053W	YNL053W	MSG5	hom	Verified	0.881509939266944	0.189020938385435	no	881	0.199431983924141	688	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION	NUCLEUS		Dual-specificity protein phosphatase; exists in 2 isoforms; required for maintenance of a low level of signaling through the cell integrity pathway, adaptive response to pheromone; regulates and is regulated by Slt2p; dephosphorylates Fus3p	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|regulation of fungal-type cell wall organization|inactivation of MAPK activity involved in cell wall biogenesis|regulation of MAPK export from nucleus|protein dephosphorylation|inactivation of MAPK activity involved in conjugation with cellular fusion	protein tyrosine/serine/threonine phosphatase activity	nucleus|cytoplasm
YEL053C	YEL053C	MAK10	hom	Verified	0.880718840891068	0.189235008265867	no	882	0.182695870716251	643	NA					Non-catalytic subunit of N-terminal acetyltransferase of the NatC type, required for replication of dsRNA virus; expression is glucose-repressible	N-terminal protein amino acid acetylation	peptide alpha-N-acetyltransferase activity	NatC complex|cytoplasm
YJL089W	YJL089W	SIP4	hom	Verified	0.880552070534024	0.189280155084814	no	883	0.198681539289408	704	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus	positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source|positive regulation of gluconeogenesis|positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter|Unknown	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YBL070C_d	YBL070C	YBL070C	hom	Dubious	0.87986749241688	0.189465548399542	no	884	0.198633513033466	646	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKL102C_d	YKL102C	YKL102C	hom	Dubious	0.879767813272675	0.189492552220829	no	885	0.177678624879391	614	NA					Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site	Unknown	Unknown	Unknown
YOR005C	YOR005C	DNL4	hom	Verified	0.879306342179023	0.189617599030626	no	886	0.169956627959392	581	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION	NUCLEUS|CHROMOSOME		DNA ligase required for nonhomologous end-joining (NHEJ), forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth	double-strand break repair via nonhomologous end joining|replicative cell aging	DNA ligase (ATP) activity	DNA ligase IV complex|nuclear chromatin
YOR023C	YOR023C	AHC1	hom	Verified	0.877380849634394	0.190139905633141	no	887	0.172670635356573	607	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS	HISTONE ACETYLTRANSFERASE	Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex	histone acetylation	histone acetyltransferase activity	Ada2/Gcn5/Ada3 transcription activator complex
YDR471W	YDR471W	RPL27B	hom	Verified	0.876390849857706	0.19040879547292	no	888	0.18602282859208	609	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L27B; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27B has a paralog, RPL27A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YFR055W_p	YFR055W	IRC7	hom	Uncharacterized	0.872718736979631	0.191408201153428	no	889	0.195410630701341	664	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Beta-lyase involved in the production of thiols; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner and by copper levels in a Mac1-dependent manner	sulfur compound metabolic process|L-cysteine catabolic process to pyruvate	cysteine-S-conjugate beta-lyase activity	cellular_component
YOR346W	YOR346W	REV1	hom	Verified	0.87229482700157	0.191523779490083	no	890	0.167906437330474	542	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION|CHROMOSOME		Deoxycytidyl transferase; involved in repair of abasic sites and adducted guanines in damaged DNA by translesion synthesis (TLS); forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; relocalizes from nucleus to cytoplasm upon DNA replication stress	error-prone translesion synthesis|error-free translesion synthesis	deoxycytidyl transferase activity|DNA-directed DNA polymerase activity	nuclear chromatin|mitochondrion|replication fork
YNR051C	YNR051C	BRE5	hom	Verified	0.871792092764331	0.191660904534346	no	891	0.191255590263996	679	NA	FT	VESICLE-MEDIATED TRANSPORT			Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A	protein deubiquitination|ribophagy|regulation of ER to Golgi vesicle-mediated transport|Unknown	molecular_function	cytoplasm
YJL073W	YJL073W	JEM1	hom	Verified	0.869118724896878	0.192391097923251	no	892	0.199625787258696	720	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		DnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane; exhibits genetic interactions with KAR2	karyogamy involved in conjugation with cellular fusion|ER-associated protein catabolic process|protein folding in endoplasmic reticulum	unfolded protein binding|chaperone binding	endoplasmic reticulum|nuclear outer membrane-endoplasmic reticulum membrane network
YDR018C_p	YDR018C	YDR018C	hom	Uncharacterized	0.86865126184761	0.192518953485305	no	893	0.185437436169669	639	NA	FT	LIPID METABOLISM			Probable membrane protein with three predicted transmembrane domains; similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase; YDR018C has a paralog, CST26, that arose from the whole genome duplication	phospholipid biosynthetic process	transferase activity, transferring acyl groups	integral to membrane
YER176W	YER176W	ECM32	hom	Verified	0.86832975379443	0.192606919115901	no	894	0.17523787746375	613	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION			DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes	regulation of translational termination	RNA helicase activity|DNA helicase activity	polysome
YBR149W	YBR149W	ARA1	hom	Verified	0.867974717394744	0.192704086745965	no	895	0.180254181244578	612	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM			NADP+ dependent arabinose dehydrogenase, involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product	cellular carbohydrate metabolic process	alditol:NADP+ 1-oxidoreductase activity|D-arabinose 1-dehydrogenase [NAD(P)+] activity	cytosol
YHR060W	YHR060W	VMA22	hom	Verified	0.867734438352605	0.192769864165125	no	896	0.196488003157969	649	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Peripheral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)	vacuolar proton-transporting V-type ATPase complex assembly|vacuolar acidification	unfolded protein binding	extrinsic to endoplasmic reticulum membrane
YDR284C	YDR284C	DPP1	hom	Verified	0.865890376663567	0.193275140468043	no	897	0.188749591462012	657	NA	FT	LIPID METABOLISM|SIGNALING			Diacylglycerol pyrophosphate (DGPP) phosphatase, zinc-regulated vacuolar membrane-associated lipid phosphatase, dephosphorylates DGPP to phosphatidate (PA) and Pi, then PA to diacylglycerol; involved in lipid signaling and cell metabolism	phospholipid metabolic process|signal transduction	diacylglycerol diphosphate phosphatase activity|phosphatidate phosphatase activity	fungal-type vacuole membrane|integral to membrane
YIR001C	YIR001C	SGN1	hom	Verified	0.86407362896337	0.193773722285474	no	898	0.191662180729455	657	NA					Cytoplasmic RNA-binding protein, contains an RNA recognition motif (RRM); may have a role in mRNA translation, as suggested by genetic interactions with genes encoding proteins involved in translational initiation	mRNA metabolic process	poly(A) RNA binding	cytoplasm
YGR014W	YGR014W	MSB2	hom	Verified	0.863459738896189	0.193942373183977	no	899	0.228068636739357	774	NA	FT	SIGNALING	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Mucin family member involved in signaling; functions in the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; is processed into secreted and cell-associated forms by the aspartyl protease, Yps1p; also functions as an osmosensor in parallel to the Sho1p-mediated pathway; potential Cdc28p substrate	signal transduction involved in filamentous growth|osmosensory signaling pathway via Sho1 osmosensor|establishment of cell polarity|hyperosmotic response|response to osmotic stress	osmosensor activity	site of polarized growth|integral to plasma membrane
YOR304W	YOR304W	ISW2	hom	Verified	0.862735633657357	0.194141417877986	no	900	0.183902976588951	593	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS		ATP-dependent DNA translocase involved in chromatin remodeling; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth	negative regulation of transcription from RNA polymerase II promoter by pheromones|nucleosome positioning|termination of RNA polymerase II transcription|negative regulation of antisense RNA transcription|chromatin silencing at rDNA|chromatin remodeling|chromatin silencing at telomere	single-stranded DNA binding|DNA translocase activity	chromatin accessibility complex|nucleus
YGL203C	YGL203C	KEX1	hom	Verified	0.862374759722843	0.194240662667264	no	901	0.192425393976821	641	NA	FT	PROTEOLYSIS	GOLGI APPARATUS		Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins	protein processing	serine-type carboxypeptidase activity	trans-Golgi network
YKR020W	YKR020W	VPS51	hom	Verified	0.862125688619212	0.194309178315052	no	902	0.234053786064304	791	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL DIVISION|VACUOLAR TRANSPORT	GOLGI APPARATUS		Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; links the (VFT/GARP) complex to the SNARE Tlg1p	vesicle organization|retrograde transport, endosome to Golgi|budding cell apical bud growth|regulation of cell size|protein targeting to vacuole	protein binding	Golgi apparatus|GARP complex
YLR177W_p	YLR177W	YLR177W	hom	Uncharacterized	0.861464961504694	0.194491005515547	no	903	0.190885577129964	620	NA					Putative protein of unknown function; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; not an essential gene; YLR177W has a paralog, PSP1, that arose from the whole genome duplication	biological_process	molecular_function	cytoplasm
YGR157W	YGR157W	CHO2	hom	Verified	0.860919038553662	0.194641317568111	no	904	0.202416831158698	650	NA	FT	LIPID METABOLISM			Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis	phosphatidylcholine biosynthetic process	phosphatidylethanolamine N-methyltransferase activity	integral to membrane|endoplasmic reticulum
YGR132C	YGR132C	PHB1	hom	Verified	0.860286746824916	0.194815498339646	no	905	0.172540052375448	562	NA	FT	MEMBRANE ORGANIZATION|PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation	mitochondrion inheritance|protein folding|negative regulation of proteolysis|replicative cell aging|mitochondrion morphogenesis|inner mitochondrial membrane organization	molecular_function	mitochondrion|mitochondrial inner membrane
YGL170C	YGL170C	SPO74	hom	Verified	0.859789353417064	0.194952584552437	no	906	0.19827000487999	679	NA	FT		NUCLEUS|CYTOSKELETON		Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation	ascospore formation	structural molecule activity	spindle pole body
YNL054W	YNL054W	VAC7	hom	Verified	0.859349474855044	0.195073868002581	no	907	0.152191799747528	545	NA	FT	LIPID METABOLISM			Integral vacuolar membrane protein involved in vacuole inheritance and morphology; activates Fab1p kinase activity under basal conditions and also after hyperosmotic shock	positive regulation of phosphatidylinositol biosynthetic process|positive regulation of kinase activity	molecular_function	fungal-type vacuole membrane|integral to membrane|PAS complex|vacuolar membrane|cytoplasm
YGL162W	YGL162W	SUT1	hom	Verified	0.858905062485121	0.195196448081912	no	908	0.187362211249597	608	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Transcription factor of the Zn2Cys6 family involved in sterol uptake; involved in induction of hypoxic gene expression; relocalizes from nucleus to cytoplasm upon DNA replication stress	positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II repressing transcription factor binding	nucleus
YGL010W_p	YGL010W	YGL010W	hom	Uncharacterized	0.858299896214783	0.195363443370721	no	909	0.194604883685278	645	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative protein of unknown function; YGL010W is not an essential gene	biological_process	molecular_function	integral to membrane|endoplasmic reticulum
YDL237W	YDL237W	AIM6	hom	Verified	0.858169597458681	0.195399410590571	no	910	0.199910685514299	669	NA					Putative protein of unknown function, required for respiratory growth; YDL237W is not an essential gene	biological_process	molecular_function	cellular_component
YJL108C	YJL108C	PRM10	hom	Verified	0.857667618649141	0.195538012685523	no	911	0.211218320723553	720	NA					Pheromone-regulated protein, proposed to be involved in mating; predicted to have 5 transmembrane segments; induced by treatment with 8-methoxypsoralen and UVA irradiation	biological_process	molecular_function	integral to membrane
YGR108W	YGR108W	CLB1	hom	Verified	0.855026870879245	0.196268136033506	no	912	0.178921588963537	650	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	NUCLEUS		B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome	G2/M transition of mitotic cell cycle|meiotic G2/MI transition|regulation of cyclin-dependent protein kinase activity|mitotic spindle organization in nucleus|positive regulation of spindle pole body separation	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex|nucleus|cytoplasm
YBR052C	YBR052C	RFS1	hom	Verified	0.854027641596907	0.196544836979024	no	913	0.150752456101862	549	NA	FT	OXIDATION-REDUCTION PROCESS			Protein of unknown function; member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; RFS1 has a paralog, PST2, that arose from the whole genome duplication	biological_process	molecular_function	membrane raft|cytoplasm
YMR297W	YMR297W	PRC1	hom	Verified	0.853405780909308	0.19671715839726	no	914	0.158911850914979	536	NA	FT	PROTEOLYSIS	ENDOPLASMIC RETICULUM		Vacuolar carboxypeptidase Y (proteinase C; CPY), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family	vacuolar protein catabolic process|phytochelatin biosynthetic process	serine-type carboxypeptidase activity	fungal-type vacuole lumen|endoplasmic reticulum|fungal-type vacuole|cytoplasm
YGR236C	YGR236C	SPG1	hom	Verified	0.853250229714801	0.196760276892405	no	915	0.193630390215106	667	NA	FT		MITOCHONDRION		Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YMR225C	YMR225C	MRPL44	hom	Verified	0.85282086625624	0.19687932532711	no	916	0.194545917398981	691	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YPR013C_p	YPR013C	CMR3	hom	Uncharacterized	0.852742783471457	0.196900979813436	no	917	0.188387570968659	640	NA					Putative zinc finger protein; YPR013C is not an essential gene	biological_process	sequence-specific DNA binding	cellular_component
YJL068C	YJL068C	YJL068C	hom	Verified	0.851217804880292	0.197324187007566	no	918	0.178485666855049	617	NA					Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D	formaldehyde catabolic process	S-formylglutathione hydrolase activity	cytosol
YFL013W-A_d	YFL013W-A	YFL013W-A	hom	Dubious	0.850269142103596	0.197587734243944	no	919	0.216148938254777	743	NA					Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps IES1/YFL013C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching	Unknown	Unknown	Unknown
YDR272W	YDR272W	GLO2	hom	Verified	0.849658012747417	0.197757624227161	no	920	0.200545836037392	671	NA	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM			Cytoplasmic glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate	cellular carbohydrate metabolic process|methylglyoxal catabolic process to D-lactate	hydroxyacylglutathione hydrolase activity	cytoplasm
YJL130C	YJL130C	URA2	hom	Verified	0.849625046163723	0.197766791231346	no	921	0.171012703294205	548	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM	MITOCHONDRION		Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP	glutamine metabolic process|'de novo' pyrimidine nucleobase biosynthetic process|negative regulation of pyrimidine nucleobase metabolic process	aspartate carbamoyltransferase activity|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	mitochondrion|integral to membrane|cytoplasm
YDR348C	YDR348C	PAL1	hom	Verified	0.848856819624747	0.197980484367165	no	922	0.19898529825913	693	NA	FT		SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Protein of unknown function thought to be involved in endocytosis; Pal1p physically interacts with Ede1p and is found at endocytic sites at the cell periphery during the early stages of endocytosis; green fluorescent protein (GFP)-fusion protein also localizes to the bud neck; potential Cdc28p substrate; similar to the S. pombe Pal1 protein; relocalizes from bud neck to cytoplasm upon DNA replication stress	biological_process	molecular_function	cell cortex|cellular bud neck|mating projection tip
YDR425W	YDR425W	SNX41	hom	Verified	0.848739744088803	0.198013062833812	no	923	0.175189939747042	611	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT			Sorting nexin, involved in the retrieval of late-Golgi SNAREs from the post-Golgi endosome to the trans-Golgi network; interacts with Snx4p	retrograde transport, endosome to Golgi	phosphatidylinositol binding|phosphatidylinositol-3-phosphate binding	endosome
YBL005W	YBL005W	PDR3	hom	Verified	0.848613866637826	0.19804809421023	no	924	0.193018651926407	672	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Transcriptional activator of the pleiotropic drug resistance network; regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements); post-translationally up-regulated in cells lacking a functional mitochondrial genome; PDR3 has a paralog, PDR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress	Unknown|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|cytoplasm
YDR136C_d	YDR136C	VPS61	hom	Dubious	0.847277222919631	0.198420309597768	no	925	0.298305788428383	992	NA	FF				Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 4% of ORF overlaps the verified gene RGP1; deletion causes a vacuolar protein sorting defect	Unknown	Unknown	Unknown
YLR121C	YLR121C	YPS3	hom	Verified	0.846943405470166	0.198513333624184	no	926	0.202237265069861	706	NA	FT	CELL WALL ORG/BIOGENESIS|PROTEOLYSIS	PLASMA MEMBRANE		Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor	fungal-type cell wall organization|cellular protein metabolic process	aspartic-type endopeptidase activity	anchored to plasma membrane|plasma membrane
YMR088C	YMR088C	VBA1	hom	Verified	0.846737256367388	0.198570793787749	no	927	0.19563162800229	652	NA					Permease of basic amino acids in the vacuolar membrane	basic amino acid transport	basic amino acid transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane
YNL296W_d	YNL296W	YNL296W	hom	Dubious	0.846645525819719	0.198596365167836	no	928	0.232520952867903	809	NA					Dubious open reading frame unlikely to encode a functional protein; deletion adversely affects sporulation; deletion mutant exhibits synthetic phenotype under expression of mutant huntingtin fragment, but gene does not have human ortholog	Unknown	Unknown	Unknown
YER063W	YER063W	THO1	hom	Verified	0.845870299262364	0.198812551471117	no	929	0.162229864532583	533	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA LOCALIZATION	NUCLEUS		Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation	poly(A)+ mRNA export from nucleus|transcription, DNA-dependent|ribonucleoprotein complex assembly	chromatin binding|double-stranded DNA binding|RNA binding	nucleus
YLR376C	YLR376C	PSY3	hom	Verified	0.845807053124754	0.198830195086689	no	930	0.194006697225089	684	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function; structural analysis reveals a similar DNA-binding region in both Psy3p and Csm2p and that both regions work together to form a single DNA binding site; deletion of PSY3 results in a mutator phenotype; deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C	recombinational repair|error-free translesion synthesis	molecular_function	nucleus|Shu complex|cytoplasm
YGL087C	YGL087C	MMS2	hom	Verified	0.845798681997918	0.198832530429571	no	931	0.19092778415576	626	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE	NUCLEUS		Ubiquitin-conjugating enzyme variant; involved in error-free postreplication repair; forms a heteromeric complex with Ubc13p, an active ubiquitin-conjugating enzyme; cooperates with chromatin-associated RING finger proteins, Rad18p and Rad5p; protein abundance increases in response to DNA replication stress	postreplication repair|response to DNA damage stimulus|protein polyubiquitination|free ubiquitin chain polymerization	ubiquitin-protein ligase activity	ubiquitin conjugating enzyme complex|nucleus|cytoplasm
YGL039W	YGL039W	YGL039W	hom	Verified	0.844509535132301	0.199192368687689	no	932	0.170917313846197	565	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS			Oxidoreductase shown to reduce carbonyl compounds to chiral alcohols	cellular ketone metabolic process|cellular aromatic compound metabolic process	oxidoreductase activity, acting on CH-OH group of donors|carbonyl reductase (NADPH) activity	cytoplasm
YJL207C	YJL207C	LAA1	hom	Verified	0.843066607400782	0.19959559652794	no	933	0.201734422733768	665	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene	protein localization|retrograde transport, endosome to Golgi	molecular_function	AP-1 adaptor complex|ribosome|clathrin-coated vesicle
YLR356W	YLR356W	ATG33	hom	Verified	0.842797932624615	0.199670732219347	no	934	0.190661141425212	650	NA	FT		MITOCHONDRION		Mitochondrial mitophagy-specific protein; required primarily for mitophagy induced at the post-log phase; not required for other types of selective autophagy or macroautophagy; conserved within fungi, but not in higher eukaryotes	mitochondrion degradation	molecular_function	mitochondrion|integral to membrane
YPL119C	YPL119C	DBP1	hom	Verified	0.842276087067247	0.199816716483193	no	935	0.18144145481335	623	NA	FT	TRANSLATION			Putative ATP-dependent RNA helicase of the DEAD-box protein family; mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs; protein abundance increases in response to DNA replication stress	translational initiation	RNA helicase activity	cytoplasm
YJR126C	YJR126C	VPS70	hom	Verified	0.840160955020503	0.200409073567033	no	936	0.186941303270775	619	NA	FT	PROTEIN LOCALIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT			Protein of unknown function involved in vacuolar protein sorting	protein targeting to vacuole	molecular_function	cellular_component
YDR541C_p	YDR541C	YDR541C	hom	Uncharacterized	0.840157414943452	0.200410065873016	no	937	0.205841951081285	703	NA	FT	OXIDATION-REDUCTION PROCESS			Putative dihydrokaempferol 4-reductase	biological_process	carbonyl reductase (NADPH) activity	cellular_component
YOR052C	YOR052C	YOR052C	hom	Verified	0.839966722410689	0.200463522557042	no	938	0.198637662840143	689	NA	FT		NUCLEUS		Nuclear protein of unknown function; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner and by weak acid; transcriptionally regulated by Rpn4p along with proteasome subunit genes; putative ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus
YDR005C	YDR005C	MAF1	hom	Verified	0.839934137123437	0.20047265802102	no	939	0.218034832623623	755	NA	FT		NUCLEUS		Highly conserved negative regulator of RNA polymerase III; binds to the N-terminal domain of the Rpc160p subunit of Pol III to prevent closed-complex formation; localization and activity are regulated by phosphorylation, mediated by TORC1, protein kinase A, and Sch9p; localizes to cytoplasm during vegetative growth and translocates to the nucleus and nucleolus under stress conditions	negative regulation of transcription from RNA polymerase III promoter	RNA polymerase III core binding	nucleolus|nucleus|cytoplasm
YOR099W	YOR099W	KTR1	hom	Verified	0.839094421528901	0.200708163128751	no	940	0.183097562232727	661	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family; relocalizes from vacuole to cytoplasm upon DNA replication stress	N-glycan processing|cell wall mannoprotein biosynthetic process|protein O-linked glycosylation	alpha-1,2-mannosyltransferase activity	Golgi apparatus
YMR008C	YMR008C	PLB1	hom	Verified	0.838934795729285	0.200752950268248	no	941	0.193000694196506	617	NA	FT	LIPID METABOLISM	PLASMA MEMBRANE		Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol	glycerophospholipid metabolic process	lysophospholipase activity	periplasmic space|plasma membrane
YDR198C	YDR198C	RKM2	hom	Verified	0.838128211630026	0.200979349982993	no	942	0.219558897877722	708	NA					Ribosomal protein lysine methyltransferase, responsible for trimethylation of the lysine residue at position 3 of Rpl12Ap and Rpl12Bp	peptidyl-lysine trimethylation|peptidyl-lysine monomethylation	protein-lysine N-methyltransferase activity	cellular_component
YIR029W	YIR029W	DAL2	hom	Verified	0.837984437114124	0.201019722063749	no	943	0.189199871041802	654	NA					Allantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation	allantoin catabolic process	allantoicase activity	cellular_component
YPL073C_d	YPL073C	YPL073C	hom	Dubious	0.836565271924518	0.201418486530532	no	944	0.182582069214296	607	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps with verified gene UBP16/YPL072W; may interact with ribosome based on co-purification experiments	Unknown	Unknown	Unknown
YNR033W	YNR033W	ABZ1	hom	Verified	0.836196464745879	0.201522193460801	no	945	0.174481344847102	586	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM			Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress	para-aminobenzoic acid biosynthetic process	4-amino-4-deoxychorismate synthase activity	cytoplasm
YGR037C	YGR037C	ACB1	hom	Verified	0.835397235632486	0.201747042879116	no	946	0.283626165247741	988	NA	FF|FT	KETONE METABOLISM|LIPID METABOLISM	NUCLEUS		Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion; protein abundance increases in response to DNA replication stress	long-chain fatty acid transport|chronological cell aging|fatty acid metabolic process	long-chain fatty acid transporter activity|fatty-acyl-CoA binding	extracellular region|nucleus|cytoplasm
YNL011C_p	YNL011C	YNL011C	hom	Uncharacterized	0.833521756105557	0.202275266516967	no	947	0.160076036943429	537	NA					Putative protein of unknown function; YNL011C is not an essential gene	biological_process	molecular_function	cellular_component
YDR051C	YDR051C	DET1	hom	Verified	0.833340461650226	0.202326371412428	no	948	0.187565849725324	599	NA	FT		NUCLEUS		Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel	intracellular sterol transport|dephosphorylation	acid phosphatase activity	nucleus|cytoplasm
YOR126C	YOR126C	IAH1	hom	Verified	0.832898872825325	0.202450882710961	no	949	0.168921208270754	590	NA	FT	KETONE METABOLISM|LIPID METABOLISM			Isoamyl acetate-hydrolyzing esterase, required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate, which is particularly important in sake brewing	acetate metabolic process	hydrolase activity, acting on ester bonds	cellular_component
YKL167C	YKL167C	MRP49	hom	Verified	0.832890985898628	0.202453106941488	no	950	0.207859729149572	694	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YMR252C_p	YMR252C	YMR252C	hom	Uncharacterized	0.832830593755775	0.202470138907472	no	951	0.184614569303409	651	NA	FT		MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YMR252C is not an essential gene	biological_process	molecular_function	mitochondrion
YPR196W_p	YPR196W	YPR196W	hom	Uncharacterized	0.832236106191794	0.202637843720782	no	952	0.192612931736212	700	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Putative maltose-responsive transcription factor	regulation of transcription, DNA-dependent	sequence-specific DNA binding	cellular_component
YDR158W	YDR158W	HOM2	hom	Verified	0.832216141052256	0.202643477322847	no	953	0.231738067939788	804	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	NUCLEUS		Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis	methionine biosynthetic process|threonine biosynthetic process|homoserine biosynthetic process	aspartate-semialdehyde dehydrogenase activity	nucleus|plasma membrane|cytoplasm
YMR313C	YMR313C	TGL3	hom	Verified	0.831890941305677	0.202735252743798	no	954	0.196626069457714	681	NA	FT	LIPID METABOLISM|CELL DIVISION			Bifunctional enzyme with triacylglycerol lipase and lysophosphatidylethanolamine acyltransferase activity; responsible for all the triacylglycerol lipase activity of the lipid particle; required with Tgl4p for timely bud formation	triglyceride catabolic process|cell budding|cellular lipid metabolic process	triglyceride lipase activity|lysophosphatidylethanolamine acyltransferase activity	lipid particle
YHL003C	YHL003C	LAG1	hom	Verified	0.829437541561979	0.203428432837001	no	955	0.173851960149237	589	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress	replicative cell aging|ceramide biosynthetic process	sphingosine N-acyltransferase activity	integral to membrane|endoplasmic reticulum
YGL165C_d	YGL165C	YGL165C	hom	Dubious	0.828483315951028	0.203698419859132	no	956	0.189808860429426	608	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CUP2/YGL166W	Unknown	Unknown	Unknown
YPL182C_d	YPL182C	YPL182C	hom	Dubious	0.826676828470368	0.204210129141749	no	957	0.204447056450536	711	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CTI6/YPL181W	Unknown	Unknown	Unknown
YPL102C_d	YPL102C	YPL102C	hom	Dubious	0.826456688416103	0.204272538742216	no	958	0.202105453134818	681	NA					Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation enhances replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene ELP4	Unknown	Unknown	Unknown
YCL036W	YCL036W	GFD2	hom	Verified	0.826361269568629	0.204299593467795	no	959	0.204654454637507	689	NA					Protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; GFD2 has a paralog, YDR514C, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YGR053C_p	YGR053C	YGR053C	hom	Uncharacterized	0.826261636605099	0.204327845325838	no	960	0.202687284687368	686	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YJL098W	YJL098W	SAP185	hom	Verified	0.826213576368283	0.20434147408676	no	961	0.202402019725337	706	NA	FT	CELL CYCLE|RNA PROCESSING	MITOCHONDRION		Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap190p; SAP185 has a paralog, SAP190, that arose from the whole genome duplication	tRNA wobble uridine modification|G1/S transition of mitotic cell cycle	protein serine/threonine phosphatase activity	mitochondrion|cytoplasm
YHR006W	YHR006W	STP2	hom	Verified	0.825569943076819	0.204524045609678	no	962	0.179967930283743	614	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS|PLASMA MEMBRANE		Transcription factor; activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes; STP2 has a paralog, STP1, that arose from the whole genome duplication	positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|cytoplasm
YDL130W-A	YDL130W-A	STF1	hom	Verified	0.822611403691156	0.205364505815201	no	963	0.221434904405557	787	NA	FT	NUCLEOTIDE METABOLISM	MITOCHONDRION		Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p act as stabilizing factors that enhance inhibitory action of the Inh1p protein; protein abundance increases in response to DNA replication stress	negative regulation of ATPase activity	molecular_function	mitochondrion|mitochondrial proton-transporting ATP synthase complex
YOR007C	YOR007C	SGT2	hom	Verified	0.821883473645851	0.205571609795289	no	964	0.187590385494269	631	NA	FT	PROTEIN LOCALIZATION			Glutamine-rich cytoplasmic cochaperone; serves as a scaffold bringing together Get4, Get5p, and other TRC complex members that are required to mediate posttranslational insertion of tail-anchored proteins into the ER membrane; interacts with the prion domain of Sup35p; amyloid sensor; plays a role in targeting chaperones to prion aggregates; has similarity to human cochaperone SGT; forms cytoplasmic foci upon DNA replication stress	response to heat|posttranslational protein targeting to membrane	molecular_function	TRC complex|cytoplasm
YEL011W	YEL011W	GLC3	hom	Verified	0.821583748314528	0.20565692092258	no	965	0.182189423849315	615	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress	glycogen biosynthetic process	1,4-alpha-glucan branching enzyme activity	cytoplasm
YNL271C	YNL271C	BNI1	hom	Verified	0.820458966979956	0.205977255928356	no	966	0.256845284611839	900	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON		Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1	barbed-end actin filament capping|actin nucleation|actin filament bundle assembly involved in cytokinetic actomyosin contractile ring assembly|establishment of mitotic spindle orientation|formin-nucleated actin cable assembly	profilin binding	incipient cellular bud site|actin filament|polarisome|plasma membrane|cellular bud neck|mating projection tip|cellular bud tip
YGR192C	YGR192C	TDH3	hom	Verified	0.820136124243476	0.206069255392674	no	967	0.212064693614046	714	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Glyceraldehyde-3-phosphate dehydrogenase, isozyme 3; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; TDH3 has a paralog, TDH2, that arose from the whole genome duplication	gluconeogenesis|reactive oxygen species metabolic process|glycolysis|apoptotic process	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity	mitochondrion|fungal-type cell wall|lipid particle|plasma membrane|cytoplasm
YAL022C	YAL022C	FUN26	hom	Verified	0.819869644736991	0.206145211561083	no	968	0.207161081769019	707	NA					Vacuolar membrane transporter with broad nucleoside selectivity; may regulate balance of nicotinamide riboside (NmR) levels between cytosol and vacuole, contributing to salvage of NmR for use in cytosolic NAD+ synthesis	nucleoside transport|nicotinamide riboside transport|transmembrane transport	nicotinamide riboside transporter activity|nucleoside transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|intracellular|membrane
YDR419W	YDR419W	RAD30	hom	Verified	0.819462879665756	0.206261186122864	no	969	0.17211370393599	551	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		DNA polymerase eta, involved in translesion synthesis during post-replication repair; catalyzes the synthesis of DNA opposite cyclobutane pyrimidine dimers and other lesions; may also have a role in protection against mitochondrial mutagenesis; mutations in human pol eta are responsible for XPV	error-prone translesion synthesis|error-free translesion synthesis	DNA-directed DNA polymerase activity	replication fork
YGR019W	YGR019W	UGA1	hom	Verified	0.818011471953644	0.206675318368504	no	970	0.192924197625176	660	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Gamma-aminobutyrate (GABA) transaminase; also known as 4-aminobutyrate aminotransferase; involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization; protein abundance increases in response to DNA replication stress	nitrogen utilization|gamma-aminobutyric acid catabolic process	4-aminobutyrate transaminase activity	intracellular
YLR020C	YLR020C	YEH2	hom	Verified	0.817578553380684	0.206798938916848	no	971	0.197225896867436	654	NA	FT	LIPID METABOLISM|CELL WALL ORG/BIOGENESIS	PLASMA MEMBRANE		Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism	cell wall mannoprotein biosynthetic process|sterol metabolic process	sterol esterase activity	integral to membrane|plasma membrane
YLR171W_d	YLR171W	YLR171W	hom	Dubious	0.816568518279487	0.207087526099755	no	972	0.218364269976892	774	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR380W	YLR380W	CSR1	hom	Verified	0.816164046312373	0.207203158586345	no	973	0.18547449932686	616	NA	FT	KETONE METABOLISM|LIPID METABOLISM|CELL WALL ORG/BIOGENESIS	MITOCHONDRION		Phosphatidylinositol transfer protein; has a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance; protein abundance increases in response to DNA replication stress	phosphatidylinositol metabolic process|Golgi to plasma membrane protein transport|Golgi to plasma membrane transport|Unknown|negative regulation of fatty acid biosynthetic process|phospholipid transport	phosphatidylinositol transporter activity|phosphatidylcholine transporter activity	cytosol|endosome|mitochondrion|lipid particle
YPL060W	YPL060W	MFM1	hom	Verified	0.816052703618434	0.207234996499107	no	974	0.238558521353214	810	NA	FT	RNA PROCESSING|ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial inner membrane magnesium transporter, involved in maintenance of mitochondrial magnesium concentrations and membrane potential; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p	mitochondrial magnesium ion transport	magnesium ion transmembrane transporter activity	integral to membrane|mitochondrial inner membrane
YDR109C_p	YDR109C	YDR109C	hom	Uncharacterized	0.815243731818985	0.207466404990091	no	975	0.189542307387204	637	NA	FT	CARBOHYDRATE METABOLISM			Putative kinase	biological_process	molecular_function	cellular_component
YJR060W	YJR060W	CBF1	hom	Verified	0.81483284249631	0.207583999417693	no	976	0.233048802339196	802	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|CHROMOSOME SEGREGATION	NUCLEUS|MITOCHONDRION|CHROMOSOME	KINETOCHORE	Dual function helix-loop-helix protein; binds the motif CACRTG present at several sites including MET gene promoters and centromere DNA element I (CDEI); affects nucleosome positioning at this motif; associates with other transcription factors such as Met4p and Isw1p to mediate transcriptional activation or repression; associates with kinetochore proteins and required for efficient chromosome segregation; protein abundance increases in response to DNA replication stress	regulation of transcription from RNA polymerase II promoter in response to methionine|negative regulation of transcription from RNA polymerase II promoter|methionine biosynthetic process|chromosome segregation|Unknown|chromatin remodeling|negative regulation of ceramide biosynthetic process by negative regulation of transcription from RNA Polymerase II promoter	RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor binding transcription factor activity|RNA polymerase II repressing transcription factor binding|centromeric DNA binding	chromosome, centromeric region|mitochondrion|nucleus|kinetochore
YDL013W	YDL013W	SLX5	hom	Verified	0.814671497228166	0.207630186377763	no	977	0.260590485939807	906	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Subunit of the Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex, stimulated by SUMO-modified substrates; contains a RING domain and two SIMs (SUMO-interacting motifs); forms SUMO-dependent nuclear foci, including DNA repair centers	protein sumoylation|telomere maintenance|response to DNA damage stimulus|protein ubiquitination	SUMO binding|ubiquitin-protein ligase activity	ubiquitin ligase complex|nucleus
YAL042C-A_d	YAL042C-A	YAL042C-A	hom	Dubious	0.812915656355777	0.208133208717102	no	978	0.20892123240975	721	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF ERV46/YAL042W; YAL042C-A is a non-essential gene	Unknown	Unknown	Unknown
YKL071W_p	YKL071W	YKL071W	hom	Uncharacterized	0.812320555546716	0.20830385931635	no	979	0.213630862122857	728	NA	FT	OXIDATION-REDUCTION PROCESS			Putative protein of unknown function; expression induced in cells treated with the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	integral to membrane|cytoplasm
YCR059C	YCR059C	YIH1	hom	Verified	0.811886615894435	0.208428347502563	no	980	0.203893056825824	691	NA	FT	TRANSLATION|PROTEIN PHOSPHORYLATION	NUCLEUS		Negative regulator of eIF2 kinase Gcn2p; competes with Gcn2p for binding to Gcn1p; may contribute to regulation of translation in response to starvation via regulation of Gcn2p; binds to monomeric actin and to ribosomes and polyribosomes; ortholog of mammalian IMPACT	negative regulation of protein phosphorylation	protein kinase inhibitor activity|ribosome binding|actin monomer binding	ribosome|nucleus|polysome|cytoplasm
YMR119W	YMR119W	ASI1	hom	Verified	0.811837917247086	0.208442320861048	no	981	0.257070302260686	875	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Putative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals; ASI1 has a paralog, ASI3, that arose from the whole genome duplication	ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity	integral to membrane|nuclear inner membrane|endoplasmic reticulum membrane
YHR021W-A_p	YHR021W-A	ECM12	hom	Uncharacterized	0.811158132704392	0.208637432682379	no	982	0.199157306805325	670	NA	FT	CELL WALL ORG/BIOGENESIS			Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity	fungal-type cell wall organization	molecular_function	cellular_component
YNL205C_d	YNL205C	YNL205C	hom	Dubious	0.811042620246493	0.208670597776502	no	983	0.212897206399067	746	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YAR020C	YAR020C	PAU7	hom	Verified	0.809658111712333	0.209068349534959	no	984	0.209969076524952	691	NA					Member of the seripauperin multigene family, active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme	biological_process	molecular_function	cellular_component
YLR416C_d	YLR416C	YLR416C	hom	Dubious	0.809609757498981	0.209082249151789	no	985	0.200813321880031	679	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOR080W	YOR080W	DIA2	hom	Verified	0.809417158260608	0.209137617992414	no	986	0.218352074258792	776	NA	FT	CELL CYCLE|PROTEOLYSIS	NUCLEUS|CHROMOSOME	UBIQUITIN LIGASE COMPLEX	Origin-binding F-box protein; forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays a role in DNA replication; plays a role in transcription; required for correct assembly of RSC complex, correct RSC-mediated transcription regulation, and correct nucleosome positioning; involved in invasive and pseudohyphal growth; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|regulation of DNA replication|invasive growth in response to glucose limitation|protein ubiquitination	ubiquitin-protein ligase activity|DNA replication origin binding	SCF ubiquitin ligase complex|nucleus|nuclear replication fork
YDL133W	YDL133W	SRF1	hom	Verified	0.808784987579125	0.209319416434308	no	987	0.26901324906701	875	NA					Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients	positive regulation of catalytic activity	molecular_function	integral to membrane
YGR026W_p	YGR026W	YGR026W	hom	Uncharacterized	0.808596869305597	0.209373533080793	no	988	0.216829929822951	710	NA	FT		PLASMA MEMBRANE		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery	biological_process	molecular_function	integral to membrane
YDR206W	YDR206W	EBS1	hom	Verified	0.808513867722421	0.209397413056154	no	989	0.216510038652032	658	NA	FT	TRANSLATION	NUCLEUS|CHROMOSOME		Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors	negative regulation of translation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	molecular_function	cytoplasmic mRNA processing body|cytoplasm
YGL213C	YGL213C	SKI8	hom	Verified	0.8080652637257	0.209526506431734	no	990	0.196122284777093	656	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE	NUCLEUS|CHROMOSOME		Ski complex component and WD-repeat protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; also required for meiotic double-strand break recombination; null mutants have superkiller phenotype	nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|protein complex assembly|nuclear-transcribed mRNA catabolic process, non-stop decay|protein-DNA complex assembly|reciprocal meiotic recombination	molecular_function	Ski complex|nuclear chromosome
YGR256W	YGR256W	GND2	hom	Verified	0.807994816760269	0.209546782988044	no	991	0.194331148057686	688	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS			6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone; GND2 has a paralog, GND1, that arose from the whole genome duplication	pentose-phosphate shunt, oxidative branch	phosphogluconate dehydrogenase (decarboxylating) activity	cytosol|plasma membrane
YNL209W	YNL209W	SSB2	hom	Verified	0.807813924301929	0.20959885405367	no	992	0.147645637711929	491	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RESPONSE TO NUTRIENT LEVELS			Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; SSB2 has a paralog, SSB1, that arose from the whole genome duplication	cellular response to glucose starvation|cytoplasmic translation|ribosomal subunit export from nucleus|rRNA processing|regulation of translational fidelity|'de novo' cotranslational protein folding	unfolded protein binding|ATPase activity	plasma membrane|polysome|cytoplasm
YDL229W	YDL229W	SSB1	hom	Verified	0.807088124429631	0.209807856759747	no	993	0.18180724145354	598	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RESPONSE TO NUTRIENT LEVELS			Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in folding of newly-made polypeptide chains; member of the HSP70 family; interacts with phosphatase subunit Reg1p; SSB1 has a paralog, SSB2, that arose from the whole genome duplication	cytoplasmic translation|cellular response to glucose starvation|translational termination|ribosomal subunit export from nucleus|regulation of translational fidelity|rRNA processing|'de novo' cotranslational protein folding	unfolded protein binding|ATPase activity|calmodulin binding	plasma membrane|polysome|cytoplasm
YEL064C	YEL064C	AVT2	hom	Verified	0.806247881964427	0.210049967523298	no	994	0.180810247176675	634	NA	FT		ENDOPLASMIC RETICULUM		Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters	transport	transporter activity	integral to membrane|endoplasmic reticulum
YLR096W	YLR096W	KIN2	hom	Verified	0.804770377910239	0.210476099221361	no	995	0.215303649072962	718	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN PHOSPHORYLATION	PLASMA MEMBRANE		Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin1p	protein autophosphorylation|exocytosis|protein phosphorylation	protein serine/threonine kinase activity|protein kinase activity	plasma membrane
YDL096C_d	YDL096C	OPI6	hom	Dubious	0.799391218744415	0.212031800312264	no	996	0.196952973871801	668	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PMT1/YDL095W; YDL096C is not essential	Unknown	Unknown	Unknown
YNL086W_p	YNL086W	SNN1	hom	Uncharacterized	0.798615678824046	0.212256646747782	no	997	0.188556400676063	645	NA					Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to endosomes	biological_process	molecular_function	endosome|BLOC-1 complex
YKR059W	YKR059W	TIF1	hom	Verified	0.798566231073713	0.212270987485425	no	998	0.211026460629538	705	NA	FT	TRANSLATION		RIBOSOME	Translation initiation factor eIF4A; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; protein abundance increases in response to DNA replication stress; TIF1 has a paralog, TIF2, that arose from the whole genome duplication	translational initiation	ATP-dependent RNA helicase activity|translation initiation factor activity	ribosome|eukaryotic translation initiation factor 4F complex
YMR019W	YMR019W	STB4	hom	Verified	0.798320392724742	0.212342293437743	no	999	0.198054051093099	615	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Putative transcription factor; contains a Zn(II)2Cys6 zinc finger domain characteristic of DNA-binding proteins; computational analysis suggests a role in regulation of expression of genes encoding transporters; binds Sin3p in a two-hybrid assay;	biological_process	sequence-specific DNA binding|DNA binding	nucleus
YNR009W	YNR009W	NRM1	hom	Verified	0.798223330853195	0.212370450300299	no	1000	0.200151372500151	669	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE	NUCLEUS		Transcriptional co-repressor of MBF (MCB binding factor)-regulated gene expression; Nrm1p associates stably with promoters via MBF to repress transcription upon exit from G1 phase	negative regulation of transcription involved in G1 phase of mitotic cell cycle	repressing transcription factor binding|transcription factor binding transcription factor activity	MBF transcription complex|nucleus|cytoplasm
YMR027W_p	YMR027W	YMR027W	hom	Uncharacterized	0.798151505645069	0.21239128761576	no	1001	0.22268877967956	779	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR027W is not an essential gene	biological_process	molecular_function	nucleus|cytoplasm
YDR374C_p	YDR374C	YDR374C	hom	Uncharacterized	0.798103257728805	0.212405285559578	no	1002	0.186348622640075	622	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YKL205W	YKL205W	LOS1	hom	Verified	0.797972687166402	0.212443170093486	no	1003	0.219963476094766	728	NA	FT	RNA PROCESSING|RNA LOCALIZATION	NUCLEUS|MITOCHONDRION		Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm	tRNA re-export from nucleus|tRNA splicing, via endonucleolytic cleavage and ligation|tRNA export from nucleus	tRNA binding|Ran GTPase binding	mitochondrion|integral to membrane|nuclear matrix|cytoplasm
YPL037C	YPL037C	EGD1	hom	Verified	0.796502848975256	0.212869910125815	no	1004	0.225183796397523	747	NA	FT	PROTEIN LOCALIZATION	NUCLEUS		Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b	'de novo' cotranslational protein folding	unfolded protein binding	nascent polypeptide-associated complex
YJR135W-A	YJR135W-A	TIM8	hom	Verified	0.796011075475689	0.213012798986763	no	1005	0.196923054431988	645	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial intermembrane space protein, forms a complex with Tim13p that delivers a subset of hydrophobic proteins to the TIM22 complex for inner membrane insertion; homolog of human TIMM8A, implicated in Mohr-Tranebjaerg syndrome	protein import into mitochondrial inner membrane	protein transporter activity	mitochondrion|integral to membrane|mitochondrial intermembrane space protein transporter complex
YJL208C	YJL208C	NUC1	hom	Verified	0.794865801299904	0.21334578471611	no	1006	0.21394612511538	719	NA	FT		NUCLEUS|MITOCHONDRION		Major mitochondrial nuclease, has RNAse and DNA endo- and exonucleolytic activities; has roles in mitochondrial recombination, apoptosis and maintenance of polyploidy	DNA catabolic process|RNA catabolic process|apoptotic process|DNA recombination	ribonuclease activity|endodeoxyribonuclease activity|exodeoxyribonuclease activity	mitochondrion|mitochondrial inner membrane|nucleus
YCL063W	YCL063W	VAC17	hom	Verified	0.793684593303092	0.213689535806402	no	1007	0.216392024765716	772	NA					Phosphoprotein involved in vacuole inheritance; degraded in late M phase of the cell cycle; acts as a vacuole-specific receptor for myosin Myo2p	vacuole inheritance	protein anchor	fungal-type vacuole membrane
YOL110W	YOL110W	SHR5	hom	Verified	0.79303960388659	0.213877374514466	no	1008	0.213450636111666	715	NA	FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Subunit of a palmitoyltransferase, composed of Shr5p and Erf2p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; palmitoylation is required for Ras2p membrane localization	protein targeting to membrane|protein palmitoylation	palmitoyltransferase activity	endoplasmic reticulum palmitoyltransferase complex|extrinsic to endoplasmic reticulum membrane
YNL211C_p	YNL211C	YNL211C	hom	Uncharacterized	0.792953720665847	0.213902393328136	no	1009	0.208522754729202	713	NA	FT		MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL211C is not an essential gene	biological_process	molecular_function	mitochondrion
YPR192W	YPR192W	AQY1	hom	Verified	0.791572570675812	0.214304972890764	no	1010	0.189328744844598	644	NA	FT		PLASMA MEMBRANE		Spore-specific water channel that mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance	ascospore formation|water transport	water channel activity	integral to membrane|plasma membrane
YKL051W	YKL051W	SFK1	hom	Verified	0.790465597160987	0.214627953038548	no	1011	0.165508282138907	547	NA	FT	LIPID METABOLISM|SIGNALING|CYTOSKELETON ORGANIZATION	PLASMA MEMBRANE		Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane	vacuole organization|inositol lipid-mediated signaling|actin cytoskeleton organization	molecular_function	integral to membrane|plasma membrane
YER134C	YER134C	YER134C	hom	Verified	0.787332796802931	0.215543537765933	no	1012	0.213923723328974	730	NA	FT		NUCLEUS		Magnesium-dependent acid phosphatase, member of the haloacid dehalogenase superfamily; non-essential gene	biological_process	acid phosphatase activity	nucleus|cytoplasm
YGR182C_d	YGR182C	YGR182C	hom	Dubious	0.786771135110415	0.215707926797307	no	1013	0.178850871025829	595	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TIM13/YGR181W	Unknown	Unknown	Unknown
YNL264C	YNL264C	PDR17	hom	Verified	0.786389049440352	0.215819798443092	no	1014	0.219366112654084	750	NA	FT	LIPID METABOLISM			Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition	Golgi to plasma membrane protein transport|phosphatidylserine metabolic process|response to drug|sterol biosynthetic process|Unknown|phospholipid transport|phospholipid biosynthetic process	phosphatidylinositol transporter activity|phosphatidylcholine transporter activity	endosome|cell periphery|cytosol|cytoplasm
YOL101C	YOL101C	IZH4	hom	Verified	0.785496842045728	0.216081160570723	no	1015	0.227922938768738	789	NA	FT	LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family; expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism; protein increases in abundance and relocalizes from nucleus to ER upon DNA replication stress	cellular zinc ion homeostasis|cellular lipid metabolic process	metal ion binding	integral to membrane|membrane
YGR248W	YGR248W	SOL4	hom	Verified	0.785236107949014	0.216157574294999	no	1016	0.204242526821638	679	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		6-phosphogluconolactonase; protein abundance increases in response to DNA replication stress; SOL4 has a paralog, SOL3, that arose from the whole genome duplication	pentose-phosphate shunt, oxidative branch	6-phosphogluconolactonase activity	cytosol|nucleus|cytoplasm
YNL279W	YNL279W	PRM1	hom	Verified	0.784983026410628	0.216231760237083	no	1017	0.219551048505493	766	NA	FT	MEMBRANE ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p	plasma membrane fusion involved in cytogamy|response to pheromone	molecular_function	integral to membrane|mating projection tip
YGL015C_p	YGL015C	YGL015C	hom	Uncharacterized	0.78355349434877	0.216651076534734	no	1018	0.198298015027997	665	NA					Putative protein of unknown function; null mutants accumulate cargo in the Golgi	biological_process	molecular_function	cellular_component
YER060W-A	YER060W-A	FCY22	hom	Verified	0.783245828704288	0.216741383769269	no	1019	0.188791966289279	610	NA					Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function	transmembrane transport	nucleobase transmembrane transporter activity	integral to membrane
YMR209C_p	YMR209C	YMR209C	hom	Uncharacterized	0.781901008933554	0.217136376018801	no	1020	0.218545724797511	753	NA					Putative S-adenosylmethionine-dependent methyltransferase; YMR209C is not an essential gene	biological_process	S-adenosylmethionine-dependent methyltransferase activity	cellular_component
YLR299W	YLR299W	ECM38	hom	Verified	0.781574626515684	0.217232301745525	no	1021	0.196828812450622	647	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Gamma-glutamyltranspeptidase, major glutathione-degrading enzyme; involved in detoxification of electrophilic xenobiotics; expression induced mainly by nitrogen starvation	xenobiotic metabolic process|glutathione catabolic process	gamma-glutamyltransferase activity	fungal-type vacuole
YOR376W_d	YOR376W	YOR376W	hom	Dubious	0.781190841136321	0.217345129850372	no	1022	0.198226230699174	639	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YOR376W is not an essential gene.	Unknown	Unknown	Unknown
YGR244C	YGR244C	LSC2	hom	Verified	0.781070093836012	0.217380635044439	no	1023	0.219447229201265	749	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Beta subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate	tricarboxylic acid cycle|succinyl-CoA metabolic process	succinate-CoA ligase (ADP-forming) activity	mitochondrion
YNR032C-A	YNR032C-A	HUB1	hom	Verified	0.780845877815133	0.217446573627179	no	1024	0.192093468304679	687	NA	FT	RNA PROCESSING			Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear	cellular protein modification process|cell morphogenesis involved in conjugation with cellular fusion|mRNA splicing, via spliceosome	protein tag	mating projection
YBR119W	YBR119W	MUD1	hom	Verified	0.780236072498788	0.217625966658855	no	1025	0.242939616361668	836	NA	FT	RNA PROCESSING	NUCLEUS		U1 snRNP A protein, homolog of human U1-A; involved in nuclear mRNA splicing	mRNA splicing, via spliceosome	U1 snRNA binding|RNA binding	U1 snRNP|U2-type prespliceosome
YMR171C	YMR171C	EAR1	hom	Verified	0.780179607112077	0.217642582011996	no	1026	0.216519579654171	738	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT			Specificity factor required for Rsp5p-dependent ubiquitination and sorting of specific cargo proteins at the multivesicular body; mRNA is targeted to the bud via the mRNA transport system involving She2p	protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	molecular_function	endosome
YDR179C	YDR179C	CSN9	hom	Verified	0.779913691818379	0.217720839372684	no	1027	0.21396293109976	673	NA	FT	SIGNALING	NUCLEUS		Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|cullin deneddylation	molecular_function	signalosome
YPR174C	YPR174C	YPR174C	hom	Verified	0.77952539414297	0.217835142328613	no	1028	0.207706642226747	671	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery; potential Cdc28p substrate; binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study; relative distribution to foci at the nuclear periphery increases upon DNA replication stress; YPR174C has a paralog, NBP1, that arose from the whole genome duplication	biological_process	molecular_function	nuclear envelope|spindle pole body
YMR054W	YMR054W	STV1	hom	Verified	0.778452953703515	0.218151015727337	no	1029	0.221341122103285	778	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Subunit a of the vacuolar-ATPase V0 domain, one of two isoforms (Stv1p and Vph1p); Stv1p is located in V-ATPase complexes of the Golgi and endosomes while Vph1p is located in V-ATPase complexes of the vacuole	vacuolar acidification	proton-transporting ATPase activity, rotational mechanism	vacuolar proton-transporting V-type ATPase, V0 domain|late endosome|integral to membrane|Golgi apparatus
YNR028W	YNR028W	CPR8	hom	Verified	0.778002774441955	0.218283688802635	no	1030	0.197882595435145	648	NA					Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; similarity to Cpr4p suggests a potential role in the secretory pathway	biological_process	peptidyl-prolyl cis-trans isomerase activity	fungal-type vacuole
YJL189W	YJL189W	RPL39	hom	Verified	0.777975670082215	0.218291678256801	no	1031	0.21716815101128	729	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YOR141C	YOR141C	ARP8	hom	Verified	0.776782620177044	0.218643516146388	no	1032	0.2222093782782	810	NA	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME|CYTOSKELETON		Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes; has mRNA binding activity	mitotic recombination|response to DNA damage stimulus|chromatin remodeling	mRNA binding|ATP-dependent 3'-5' DNA helicase activity	nucleus|Ino80 complex
YIL013C	YIL013C	PDR11	hom	Verified	0.776780218670523	0.21864422469475	no	1033	0.223134438057696	777	NA	FT	NUCLEOTIDE METABOLISM			ATP-binding cassette (ABC) transporter, multidrug transporter involved in multiple drug resistance; mediates sterol uptake when sterol biosynthesis is compromised; regulated by Pdr1p; required for anaerobic growth	sterol transport	ATPase activity, coupled to transmembrane movement of substances	integral to membrane|membrane
YDR077W	YDR077W	SED1	hom	Verified	0.776300038334735	0.218785925228053	no	1034	0.210206582089129	705	NA	FT	CELL WALL ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Major stress-induced structural GPI-cell wall glycoprotein in stationary-phase cells, associates with translating ribosomes, possible role in mitochondrial genome maintenance; ORF contains two distinct variable minisatellites	fungal-type cell wall organization|mitochondrial genome maintenance	structural constituent of cell wall	mitochondrion|ribosome|fungal-type cell wall
YDR289C	YDR289C	RTT103	hom	Verified	0.776030020418277	0.218865630338376	no	1035	0.238955760113388	823	NA	FT	RNA PROCESSING	NUCLEUS|CHROMOSOME		Protein that interacts with exonuclease Rat1p and Rai1p and plays a role in transcription termination by RNA polymerase II, has an RPR domain (carboxy-terminal domain interacting domain); also involved in regulation of Ty1 transposition	negative regulation of transposition, RNA-mediated|mRNA 3'-end processing	RNA polymerase II core binding	nuclear chromatin|site of double-strand break
YJL083W	YJL083W	TAX4	hom	Verified	0.775540942553168	0.219010041080674	no	1036	0.187587114594558	623	NA	FT	LIPID METABOLISM|SIGNALING|CELL WALL ORG/BIOGENESIS|RESPONSE TO NUTRIENT LEVELS			EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; TAX4 has a paralog, IRS4, that arose from the whole genome duplication	autophagy|fungal-type cell wall organization|inositol lipid-mediated signaling|CVT pathway|cellular response to starvation	molecular_function	pre-autophagosomal structure
YNL135C	YNL135C	FPR1	hom	Verified	0.774724195277028	0.219251325384342	no	1037	0.23584916558797	816	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|CHROMATIN ORGANIZATION	NUCLEUS|MITOCHONDRION		Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function	protein folding|chromatin organization|homoserine metabolic process	peptidyl-prolyl cis-trans isomerase activity|macrolide binding	mitochondrion|nucleus|cytoplasm
YPL116W	YPL116W	HOS3	hom	Verified	0.774413236468593	0.219343229294096	no	1038	0.195667570644059	654	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION	NUCLEUS|SITE OF POLARIZED GROWTH		Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) with specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats	regulation of transcription involved in G1/S phase of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|histone deacetylation	histone deacetylase activity	nucleus|cellular bud neck|cytoplasm
YBL059W_p	YBL059W	YBL059W	hom	Uncharacterized	0.774047877710172	0.219451239395842	no	1039	0.237052703942704	800	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YBL059W has a paralog, YER093C-A, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrion
YGR194C	YGR194C	XKS1	hom	Verified	0.77362379367671	0.219576648614713	no	1040	0.189655533158374	638	NA	FT	CARBOHYDRATE METABOLISM			Xylulokinase, converts D-xylulose and ATP to xylulose 5-phosphate and ADP; rate limiting step in fermentation of xylulose; required for xylose fermentation by recombinant S. cerevisiae strains	xylulose catabolic process	xylulokinase activity	cytoplasm
YDR358W	YDR358W	GGA1	hom	Verified	0.770944715957245	0.220369850474043	no	1041	0.20310278021655	678	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT	GOLGI APPARATUS		Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi	Golgi to vacuole transport|protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|Golgi to endosome transport	ubiquitin binding	trans-Golgi network
YOR337W	YOR337W	TEA1	hom	Verified	0.768581442886697	0.221070912667551	no	1042	0.21600830540165	767	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Ty1 enhancer activator required for full levels of Ty enhancer-mediated transcription; C6 zinc cluster DNA-binding protein	transcription, DNA-dependent	sequence-specific DNA binding|DNA binding	nucleus
YER078C	YER078C	ICP55	hom	Verified	0.768023183236021	0.221236705898836	no	1043	0.220135157518341	770	NA	FT	PROTEOLYSIS	NUCLEUS|MITOCHONDRION		Mitochondrial aminopeptidase; cleaves the N termini of at least 38 imported proteins after cleavage by the mitochondrial processing peptidase (MPP), thereby increasing their stability; member of the aminopeptidase P family	protein stabilization|protein processing	aminopeptidase activity	extrinsic to mitochondrial inner membrane|mitochondrion|nucleus
YOR193W	YOR193W	PEX27	hom	Verified	0.767695577973457	0.221334031966801	no	1044	0.216894639576212	711	NA	FT	PEROXISOME ORGANIZATION			Peripheral peroxisomal membrane protein involved in controlling peroxisome size and number, interacts with homologous protein Pex25p	peroxisome organization	molecular_function	peroxisomal membrane
YER044C-A	YER044C-A	MEI4	hom	Verified	0.767268076995468	0.221461072203664	no	1045	0.204724285236001	698	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Meiosis-specific protein involved in double-strand break formation during meiotic recombination; required for chromosome synapsis and production of viable spores	meiotic DNA double-strand break formation	molecular_function	condensed nuclear chromosome
YDL234C	YDL234C	GYP7	hom	Verified	0.76473885041624	0.222213533482439	no	1046	0.188493097715218	645	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|NUCLEOTIDE METABOLISM			GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking	regulation of vacuole fusion, non-autophagic|vesicle-mediated transport	Rab GTPase activator activity	cytoplasm
YKL101W	YKL101W	HSL1	hom	Verified	0.764646826109938	0.222240938788302	no	1047	0.231159221722023	791	NA	FT	CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p	G2/M transition of mitotic cell cycle|regulation of cell cycle|cell shape checkpoint|protein autophosphorylation|protein phosphorylation|septin checkpoint	protein kinase activity	cellular bud neck|septin ring
YLR168C	YLR168C	UPS2	hom	Verified	0.763525869972061	0.222574920009022	no	1048	0.223349195664199	783	NA	FT	LIPID METABOLISM|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial protein involved in phospholipid metabolism; localizes to the intermembrane space; has a role in regulation of phospholipid metabolism by inhibiting conversion of phosphatidylethanolamine to phosphatidylcholine; null mutant has defects in mitochondrial morphology; similar to Ups1p, Ups3p and to human PRELI	cristae formation|Unknown|phosphatidylethanolamine metabolic process|cardiolipin metabolic process	molecular_function	extrinsic to mitochondrial inner membrane|mitochondrion|mitochondrial intermembrane space
YNL243W	YNL243W	SLA2	hom	Verified	0.760876738246435	0.223365346881828	no	1049	0.224043330289992	758	NA	FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON		Adaptor protein that links actin to clathrin and endocytosis; involved in membrane cytoskeleton assembly and cell polarization; present in the actin cortical patch of the emerging bud tip; dimer in vivo	bipolar cellular bud site selection|fungal-type cell wall organization|actin filament organization|endocytosis|exocytosis	protein binding, bridging	incipient cellular bud site|mating projection tip|actin cortical patch
YJR134C	YJR134C	SGM1	hom	Verified	0.760813914513828	0.223384111096316	no	1050	0.219263506464625	734	NA	FT		GOLGI APPARATUS		Protein of unknown function, required for wild-type growth rate on galactose and mannose; localizes to COPI coated vesicles and the Golgi apparatus	biological_process	molecular_function	COPI-coated vesicle|Golgi apparatus
YNL042W	YNL042W	BOP3	hom	Verified	0.760553749709191	0.223461826758812	no	1051	0.19675902333204	644	NA	FT		NUCLEUS		Protein of unknown function, potential Cdc28p substrate; overproduction confers resistance to methylmercury	cellular response to methylmercury	molecular_function	nucleus|cytoplasm
YPR017C	YPR017C	DSS4	hom	Verified	0.759529802543566	0.223767846589437	no	1052	0.23470535700138	827	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING			Guanine nucleotide dissociation stimulator for Sec4p, functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol	post-Golgi vesicle-mediated transport	zinc ion binding|guanyl-nucleotide exchange factor activity	cytosol|membrane
YHR127W	YHR127W	YHR127W	hom	Verified	0.758760997410297	0.223997770429018	no	1053	0.214363352262483	711	NA	FT	CELL CYCLE|CYTOSKELETON ORGANIZATION	NUCLEUS		Protein of unknown function; localizes to the nucleus; required for asymmetric localization of Kar9p during mitosis	mitotic spindle elongation	molecular_function	nucleus
YCR082W	YCR082W	AHC2	hom	Verified	0.758306200207961	0.224133848185789	no	1054	0.23422402510956	813	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS	HISTONE ACETYLTRANSFERASE	Component of the ADA histone acetyltransferase complex; Ach2p and Ach1p are unique to the ADA complex and not shared with the related SAGA and SLIK complexes; may tether Ach1p to the complex	histone acetylation	histone acetyltransferase activity	Ada2/Gcn5/Ada3 transcription activator complex|nucleus|cytoplasm
YDR139C	YDR139C	RUB1	hom	Verified	0.758286958911222	0.224139606319747	no	1055	0.195868637522483	653	NA					Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme)	protein neddylation	protein tag	cytoplasm
YLR119W	YLR119W	SRN2	hom	Verified	0.757072761190372	0.22450313597678	no	1056	0.232552596417267	809	NA	FT	PROTEIN LOCALIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT			Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus	protein targeting to membrane|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein targeting to vacuole	protein binding	endosome|ESCRT I complex
YGR051C_d	YGR051C	YGR051C	hom	Dubious	0.757013723919801	0.224520820204981	no	1057	0.211490773179712	728	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene	Unknown	Unknown	Unknown
YLR265C	YLR265C	NEJ1	hom	Verified	0.756787754444507	0.224588515184979	no	1058	0.211257752370077	663	NA	FT	RESPONSE TO DNA DAMAGE	ENDOMEMBRANE SYSTEM|NUCLEUS		Protein involved in regulation of nonhomologous end joining; interacts with DNA ligase IV components Dnl4p and Lif1p; repressed by MAT heterozygosity; regulates cellular distribution of Lif1p	double-strand break repair via nonhomologous end joining|double-strand break repair via single-strand annealing	DNA end binding	DNA ligase IV complex|nucleus
YPR051W	YPR051W	MAK3	hom	Verified	0.755227333066509	0.225056295558346	no	1059	0.26253214169536	930	NA	FT		NUCLEUS		Catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus	N-terminal protein amino acid acetylation	peptide alpha-N-acetyltransferase activity	NatC complex
YBR085W	YBR085W	AAC3	hom	Verified	0.754751487299838	0.225199053537093	no	1060	0.208698559082815	724	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Aac1p; has roles in maintenance of viability and in respiration; AAC3 has a paralog, PET9, that arose from the whole genome duplication	heme biosynthetic process|heme transport|anaerobic respiration|transmembrane transport	ATP:ADP antiporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YDL117W	YDL117W	CYK3	hom	Verified	0.754078117142211	0.225401158221243	no	1061	0.221916024559789	737	NA	FT	CELL CYCLE|CELL DIVISION	SITE OF POLARIZED GROWTH|CYTOSKELETON		SH3-domain protein located in the bud neck and cytokinetic actin ring; relocalizes from bud neck to nucleus upon DNA replication stress; activates the chitin synthase activity of Chs2p during cytokinesis; suppressor of growth and cytokinesis defects of chs2 phospho-mutants	barrier septum assembly involved in cell cycle cytokinesis|cytokinesis	molecular_function	cellular bud neck contractile ring|cellular bud neck|cytoplasm
YPR030W	YPR030W	CSR2	hom	Verified	0.753807054655942	0.2254825436399	no	1062	0.23790929987302	826	NA	FT	VESICLE-MEDIATED TRANSPORT|TRANSCRIPTION FROM RNA POL II|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS	NUCLEUS		Nuclear ubiquitin protein ligase binding protein; may regulate utilization of nonfermentable carbon sources and endocytosis of plasma membrane proteins; overproduction suppresses chs5 spa2 lethality at high temp; ubiquitinated by Rsp5p, deubiquitinated by Ubp2p; CSR2 has a paralog, ECM21, that arose from the whole genome duplication	fungal-type cell wall organization|regulation of transcription from RNA polymerase II promoter|ubiquitin-dependent endocytosis	ubiquitin protein ligase binding	nucleus
YDR096W	YDR096W	GIS1	hom	Verified	0.753214855849124	0.225660406798278	no	1063	0.217757458711836	707	NA	FT	TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS	NUCLEUS|MITOCHONDRION		Histone demethylase and transcription factor; regulates genes during nutrient limitation; negatively regulates DPP1, PHR1; activity modulated by limited proteasome-mediated proteolysis; has JmjC and JmjN domain in N-terminal region that interact, promoting stability and proper transcriptional activity; contains two transactivating domains downstream of Jmj domains and a C-terminal DNA binding domain; GIS1 has a paralog, RPH1, that arose from the whole genome duplication	negative regulation of transcription from RNA polymerase II promoter|chronological cell aging|regulation of phospholipid biosynthetic process|histone demethylation|positive regulation of transcription from RNA polymerase II promoter|maintenance of stationary phase in response to starvation	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|histone demethylase activity (H3-K36 specific)	mitochondrion|nucleus
YDR505C	YDR505C	PSP1	hom	Verified	0.75111035403419	0.22629312246981	no	1064	0.213310880020063	703	NA	FT		MITOCHONDRION		Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrion|cytoplasm
YJL059W	YJL059W	YHC3	hom	Verified	0.749905633790167	0.22665577058057	no	1065	0.21400730993236	725	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT			Vacuolar membrane protein involved in the ATP-dependent transport of arginine into the vacuole and possibly in balancing ion homeostasis; homolog of human CLN3 involved in Batten disease (juvenile onset neuronal ceroid lipofuscinosis)	basic amino acid transport|regulation of intracellular pH|arginine transport	molecular_function	integral to membrane|fungal-type vacuole
YOR321W	YOR321W	PMT3	hom	Verified	0.74930112023647	0.22683786638378	no	1066	0.215134776738573	758	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt5p, can instead interact with Pmt1p in some conditions; antifungal drug target; PMT3 has a paralog, PMT2, that arose from the whole genome duplication	protein O-linked glycosylation|protein O-linked mannosylation	dolichyl-phosphate-mannose-protein mannosyltransferase activity	integral to membrane|dolichyl-phosphate-mannose-protein mannosyltransferase complex
YOL081W	YOL081W	IRA2	hom	Verified	0.749100547494384	0.226898302538002	no	1067	0.234091146736791	815	NA	FT	SIGNALING|NUCLEOTIDE METABOLISM	MITOCHONDRION|PLASMA MEMBRANE		GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions; similar to human neurofibromin; IRA2 has a paralog, IRA1, that arose from the whole genome duplication	negative regulation of cAMP biosynthetic process|negative regulation of Ras protein signal transduction|positive regulation of Ras GTPase activity|response to stress	Ras GTPase activator activity	mitochondrion|integral to membrane|cytoplasm
YGL133W	YGL133W	ITC1	hom	Verified	0.747956080721513	0.227243324554612	no	1068	0.230520374452396	796	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS		Subunit of the ATP-dependent Isw2p-Itc1p chromatin remodeling complex, required for repression of a-specific genes, repression of early meiotic genes during mitotic growth, and repression of INO1; similar to mammalian Acf1p, the regulatory subunit of the mammalian ATP-utilizing chromatin assembly and modifying factor (ACF) complex	negative regulation of transcription from RNA polymerase II promoter by pheromones|chromatin remodeling|chromatin silencing at telomere	molecular_function	chromatin accessibility complex
YGL161C	YGL161C	YIP5	hom	Verified	0.747520175384493	0.227374814503197	no	1069	0.23194304717929	802	NA	FT		GOLGI APPARATUS		Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport	biological_process	Rab GTPase binding	integral to membrane|Golgi apparatus
YNL242W	YNL242W	ATG2	hom	Verified	0.747510589104109	0.227377706666567	no	1070	0.218073873503261	737	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION			Peripheral membrane protein required for autophagic vesicle formation; also required for vesicle formation during pexophagy and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria; forms cytoplasmic foci upon DNA replication stress	mitochondrion degradation|piecemeal microautophagy of nucleus|peroxisome degradation|CVT pathway|autophagic vacuole assembly	molecular_function	pre-autophagosomal structure|cytoplasm|extrinsic to membrane
YDR503C	YDR503C	LPP1	hom	Verified	0.747193949021098	0.227473248051331	no	1071	0.207125638305248	693	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Lipid phosphate phosphatase, catalyzes Mg(2+)-independent dephosphorylation of phosphatidic acid (PA), lysophosphatidic acid, and diacylglycerol pyrophosphate; involved in control of the cellular levels of phosphatidylinositol and PA	phospholipid metabolic process	phosphatidate phosphatase activity	integral to membrane|membrane
YCR079W	YCR079W	PTC6	hom	Verified	0.746893711734755	0.227563861019504	no	1072	0.243145744859449	861	NA	FT	RESPONSE TO NUTRIENT LEVELS	MITOCHONDRION		Mitochondrial type 2C protein phosphatase (PP2C) with similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase	mitochondrion degradation|positive regulation of catalytic activity|macroautophagy|protein dephosphorylation	protein serine/threonine phosphatase activity	mitochondrion|mitochondrial matrix|mitochondrial intermembrane space
YAL042W	YAL042W	ERV46	hom	Verified	0.745834156142148	0.227883802060545	no	1073	0.242245949392034	799	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Protein localized to COPII-coated vesicles, forms a complex with Erv41p; involved in the membrane fusion stage of transport	ER to Golgi vesicle-mediated transport	molecular_function	integral to endoplasmic reticulum membrane|integral to Golgi membrane|ER to Golgi transport vesicle
YAR028W_p	YAR028W	YAR028W	hom	Uncharacterized	0.7456655540209	0.22793473611113	no	1074	0.243392815122766	832	NA					Putative integral membrane protein, member of DUP240 gene family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	cellular_component
YDL223C	YDL223C	HBT1	hom	Verified	0.745517037952914	0.227979607547459	no	1075	0.259124638662733	914	NA					Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis	cell morphogenesis involved in conjugation with cellular fusion	molecular_function	plasma membrane|mating projection
YJL106W	YJL106W	IME2	hom	Verified	0.745115676005245	0.228100896636373	no	1076	0.218898594480486	722	NA	FT	CELL CYCLE|PROTEIN PHOSPHORYLATION	NUCLEUS		Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p	protein phosphorylation|regulation of meiosis	protein kinase activity	nucleus
YER140W	YER140W	EMP65	hom	Verified	0.743167238828574	0.228690217634923	no	1077	0.220706108645838	759	NA	FT		MITOCHONDRION		ER membrane protein of unknown function; forms an ER-membrane associated protein complex with Slp1p; identified along with SLP1 in a screen for mutants defective in the unfolded protein response (UPR); proposed to function in the folding of integral membrane proteins; interacts genetically with MPS1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	protein folding in endoplasmic reticulum	molecular_function	mitochondrion|integral to membrane
YBR197C	YBR197C	YBR197C	hom	Verified	0.742140359828962	0.229001149404593	no	1078	0.229957809972166	783	NA	FT		NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR197C is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress; YBR197C has a paralog, YPL077C, that arose from the whole genome duplication	biological_process	molecular_function	nucleus|cytoplasm
YDR395W	YDR395W	SXM1	hom	Verified	0.741399881513593	0.229225508158373	no	1079	0.229093894107581	787	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS		Nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucleoplasm; similar to Nmd5p, Cse1p, Lph2p, and the human cellular apoptosis susceptibility protein, CAS1	mRNA export from nucleus|nucleocytoplasmic transport	protein transporter activity	integral to membrane|nucleus|cytoplasm
YLR174W	YLR174W	IDP2	hom	Verified	0.740601256894167	0.229467622852225	no	1080	0.203402325349269	688	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM			Cytosolic NADP-specific isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose; IDP2 has a paralog, IDP3, that arose from the whole genome duplication	glutamate biosynthetic process|isocitrate metabolic process	isocitrate dehydrogenase (NADP+) activity	cytosol
YCR092C	YCR092C	MSH3	hom	Verified	0.740272562911383	0.229567312838204	no	1081	0.236385435796139	843	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Mismatch repair protein, forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability	mismatch repair|mitotic recombination|meiotic mismatch repair|removal of nonhomologous ends|DNA recombination	DNA insertion or deletion binding|mismatched DNA binding|double-strand/single-strand DNA junction binding|loop DNA binding|Y-form DNA binding	MutSbeta complex|nucleus|cytoplasm
YER180C	YER180C	ISC10	hom	Verified	0.73714153088715	0.230518142736158	no	1082	0.225543348857338	801	NA	FT	CELL CYCLE			Protein required for sporulation, transcript is induced 7.5 hours after induction of meiosis, expected to play significant role in the formation of reproductive cells	sporulation resulting in formation of a cellular spore	molecular_function	cellular_component
YNL323W	YNL323W	LEM3	hom	Verified	0.73684909768663	0.230607060921829	no	1083	0.322140364701461	1103	NA	FF|FT	MEMBRANE ORGANIZATION|SIGNALING	ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Membrane protein of the plasma membrane and ER, interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane	phospholipid translocation|cell surface receptor signaling pathway	phospholipid-translocating ATPase activity	integral to membrane|endoplasmic reticulum|plasma membrane|cytoplasm
YMR086W	YMR086W	SEG1	hom	Verified	0.736535092299509	0.230702559750835	no	1084	0.226210274854737	780	NA					Component of eisosome required for proper eisosome assembly; precedes Pil1p/Lsp1p during eisosome formation and controls eisosome length and shape; Seg1p-GFP diffusely distributed and forms heterogeneous patches at the plasma membrane in small buds, also found in medium and large buds; may interact with ribosomes, based on co-purification experiments; expression is repressed by cAMP; similar to A. gossypii SEG gene and to S. pombe Sle1p, important for generating eisosomes	biological_process	molecular_function	eisosome|ribosome|cytoplasm
YGR072W	YGR072W	UPF3	hom	Verified	0.735678141418009	0.230963297622511	no	1085	0.219349074071194	728	NA	FT		NUCLEUS		Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance	nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|translational frameshifting|protein ubiquitination	molecular_function	nucleolus|nucleus|polysome|cytoplasm
YPR001W	YPR001W	CIT3	hom	Verified	0.735477367810095	0.231024409246535	no	1086	0.24937514769522	846	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate	propionate catabolic process, 2-methylcitrate cycle|propionate metabolic process|tricarboxylic acid cycle	2-methylcitrate synthase activity|citrate (Si)-synthase activity	mitochondrion
YIL002C	YIL002C	INP51	hom	Verified	0.735351296097518	0.231062787663338	no	1087	0.268008912249917	919	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION	CYTOSKELETON		Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in phosphatidylinositol 4,5-bisphosphate homeostasis and in endocytosis; null mutation confers cold-tolerant growth	phosphatidylinositol dephosphorylation	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	membrane|cytoplasm
YMR251W-A	YMR251W-A	HOR7	hom	Verified	0.73399851428912	0.231474821788369	no	1088	0.21416462215702	752	NA	FT		ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Protein of unknown function; overexpression suppresses Ca2+ sensitivity of mutants lacking inositol phosphorylceramide mannosyltransferases Csg1p and Csh1p; transcription is induced under hyperosmotic stress and repressed by alpha factor; HOR7 has a paralog, DDR2, that arose from the whole genome duplication	plasma membrane organization	molecular_function	endoplasmic reticulum|plasma membrane
YMR201C	YMR201C	RAD14	hom	Verified	0.733226150036133	0.231710254276418	no	1089	0.239384193134389	827	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein	nucleotide-excision repair, DNA damage recognition	damaged DNA binding|zinc ion binding	nucleotide-excision repair factor 1 complex|nucleus
YDR094W_d	YDR094W	YDR094W	hom	Dubious	0.732934445852416	0.231799206403125	no	1090	0.201135362105824	661	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2	Unknown	Unknown	Unknown
YDR263C	YDR263C	DIN7	hom	Verified	0.731972463883677	0.232092687468541	no	1091	0.241901523148853	818	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION		Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination	DNA repair	nuclease activity	mitochondrion
YOR273C	YOR273C	TPO4	hom	Verified	0.731410322812254	0.232264280941214	no	1092	0.314076107590866	1062	NA	FF|FT		PLASMA MEMBRANE		Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane	spermidine transport|spermine transport	spermidine transmembrane transporter activity|spermine transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|plasma membrane
YIL141W_d	YIL141W	YIL141W	hom	Dubious	0.730412725968015	0.232568970936326	no	1093	0.224696770757267	800	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YHL039W	YHL039W	EFM1	hom	Verified	0.729429404777073	0.232869518156265	no	1094	0.235473483699543	834	NA					Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	peptidyl-lysine monomethylation	protein-lysine N-methyltransferase activity	cytoplasm
YKL123W_d	YKL123W	YKL123W	hom	Dubious	0.727679072223955	0.233405032056424	no	1095	0.244176013133564	826	NA					Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene SSH4	Unknown	Unknown	Unknown
YER092W	YER092W	IES5	hom	Verified	0.727641760285645	0.233416455068952	no	1096	0.241601706747061	852	NA	FT		NUCLEUS		Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions	biological_process	molecular_function	nucleus
YLR154C	YLR154C	RNH203	hom	Verified	0.727279521194898	0.233527370323568	no	1097	0.21356799053985	721	NA	FT		NUCLEUS		Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS3 that causes Aicardi-Goutieres syndrome	RNA catabolic process|DNA replication, removal of RNA primer	ribonuclease H activity	ribonuclease H2 complex|nucleus|cytoplasm
YGR133W	YGR133W	PEX4	hom	Verified	0.727114204510323	0.23357799893007	no	1098	0.214063839572161	706	NA	FT	PROTEIN LOCALIZATION|SIGNALING|PEROXISOME ORGANIZATION			Peroxisomal ubiquitin conjugating enzyme required for peroxisomal matrix protein import and peroxisome biogenesis	peroxisome organization|protein import into peroxisome matrix, receptor recycling|protein autoubiquitination|protein monoubiquitination|protein polyubiquitination	ubiquitin-protein ligase activity	peroxisome
YER162C	YER162C	RAD4	hom	Verified	0.727058018325815	0.233595207461246	no	1099	0.233600556719365	836	NA	FT	RESPONSE TO DNA DAMAGE|PROTEOLYSIS	NUCLEUS		Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair; subunit of Nuclear Excision Repair Factor 2 (NEF2); also involved, with Rad23p, in turnover of ubiquitylated proteins	proteasomal ubiquitin-dependent protein catabolic process|nucleotide-excision repair	damaged DNA binding	cytosol|nucleotide-excision repair factor 2 complex|nucleus
YDL027C_p	YDL027C	YDL027C	hom	Uncharacterized	0.727040744830186	0.233600498075459	no	1100	0.230953248319782	778	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL027C is not an essential gene	biological_process	molecular_function	mitochondrion
YML081C-A	YML081C-A	ATP18	hom	Verified	0.725786040110062	0.233984973075927	no	1101	0.218053081665827	728	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms	mitochondrial proton-transporting ATP synthase complex assembly|ATP synthesis coupled proton transport	hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism	mitochondrion|mitochondrial proton-transporting ATP synthase complex|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
YDR496C	YDR496C	PUF6	hom	Verified	0.725165523023498	0.234175245536012	no	1102	0.210409455152898	696	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION	NUCLEUS|SITE OF POLARIZED GROWTH	RIBOSOME	Pumilio-homology domain protein that binds the 3' UTR of ASH1 mRNA and represses its translation, resulting in proper asymmetric localization of ASH1 mRNA; also co-sediments with the 60S ribosomal subunit and is required for its biogenesis	ribosomal large subunit biogenesis|negative regulation of translation	mRNA 3'-UTR binding|translation repressor activity, nucleic acid binding	nucleolus|nucleus|large ribosomal subunit
YNL229C	YNL229C	URE2	hom	Verified	0.723279074412167	0.234754223099358	no	1103	0.292576439310877	990	NA	FF|FT	PROTEIN LOCALIZATION			Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion	regulation of nitrogen utilization|response to aluminum ion|protein urmylation|cytoplasmic sequestering of transcription factor	glutathione peroxidase activity|phosphoprotein binding|transcription corepressor activity	cytosol
YIL127C_p	YIL127C	RRT14	hom	Uncharacterized	0.722884013829941	0.234875572880645	no	1104	0.222977144052552	786	NA	FT		NUCLEUS		Putative protein of unknown function; identified in a screen for mutants with decreased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis	biological_process	molecular_function	nucleolus
YOR347C	YOR347C	PYK2	hom	Verified	0.722880217844216	0.234876739052319	no	1105	0.205485774116935	711	NA	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Pyruvate kinase; appears to be modulated by phosphorylation; transcription repressed by glucose, and Pyk2p may be active under low glycolytic flux; PYK2 has a paralog, CDC19, that arose from the whole genome duplication	pyruvate metabolic process	pyruvate kinase activity	cytosol|mitochondrion
YGL033W	YGL033W	HOP2	hom	Verified	0.721580340434479	0.235276264868306	no	1106	0.27354597647157	953	NA	FF|FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair	synapsis|reciprocal meiotic recombination	protein binding|double-stranded DNA binding	condensed nuclear chromosome
YOL121C	YOL121C	RPS19A	hom	Verified	0.721314663966842	0.235357968421984	no	1107	0.239500961034386	802	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; required for assembly and maturation of pre-40 S particles; homologous to mammalian ribosomal protein S19, no bacterial homolog; mutations in human RPS19 are associated with Diamond Blackfan anemia; RPS19A has a paralog, RPS19B, that arose from the whole genome duplication	cytoplasmic translation|ribosomal small subunit biogenesis|rRNA export from nucleus	structural constituent of ribosome	cytosolic small ribosomal subunit
YBL043W	YBL043W	ECM13	hom	Verified	0.72054471256555	0.235594840216859	no	1108	0.195581993672255	630	NA	FT	CELL WALL ORG/BIOGENESIS			Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; ECM13 has a paralog, YJR115W, that arose from the whole genome duplication	fungal-type cell wall organization	molecular_function	cellular_component
YIL097W	YIL097W	FYV10	hom	Verified	0.718332568897743	0.236276126564818	no	1109	0.243303852870849	842	NA	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS	NUCLEUS		Subunit of GID complex; involved in proteasome-dependent catabolite inactivation of gluconeogenic enzymes FBPase, PEPCK, and c-MDH; forms dimer with Rmd5p that is then recruited to GID Complex by Gid8p; contains a degenerate RING finger motif needed for GID complex ubiquitin ligase activity in vivo, as well as CTLH and CRA domains; plays role in anti-apoptosis; required for survival upon exposure to K1 killer toxin	negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis	ubiquitin-protein ligase activity	nucleus|GID complex|cytoplasm
YJR127C	YJR127C	RSF2	hom	Verified	0.718294632176404	0.236287819604855	no	1110	0.190922543687502	656	NA	FT		NUCLEUS		Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress	regulation of transcription, DNA-dependent	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YBL036C	YBL036C	YBL036C	hom	Verified	0.715849062141962	0.237042277028253	no	1111	0.198478378325536	628	NA					Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS	biological_process	pyridoxal phosphate binding	cellular_component
YPL179W	YPL179W	PPQ1	hom	Verified	0.715751178546566	0.237072501609173	no	1112	0.239537666596385	816	NA	FT	TRANSLATION			Putative protein serine/threonine phosphatase; null mutation enhances efficiency of translational suppressors	protein dephosphorylation|regulation of translation	protein serine/threonine phosphatase activity	cytoplasm
YJR005C-A_p	YJR005C-A	YJR005C-A	hom	Uncharacterized	0.71485816441814	0.237348345051299	no	1113	0.22541268677446	748	NA					Putative protein of unknown function; originally identified as a syntenic homolog of an <i>Ashbya gossypii</i> gene; YJR005C-A has a paralog, YGR169C-A, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YMR285C	YMR285C	NGL2	hom	Verified	0.714830647841743	0.237356847454095	no	1114	0.212162566888954	703	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p; NGL2 has a paralog, NGL3, that arose from the whole genome duplication	rRNA processing	endoribonuclease activity	intracellular
YLR366W_d	YLR366W	YLR366W	hom	Dubious	0.71159687234209	0.238357222183172	no	1115	0.235605549235604	779	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR364C-A	Unknown	Unknown	Unknown
YGL006W	YGL006W	PMC1	hom	Verified	0.711194801010104	0.238481764924506	no	1116	0.226070511629724	776	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS			Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions; prevents growth inhibition by activation of calcineurin in the presence of elevated concentrations of calcium; similar to mammalian PMCA1a	cellular calcium ion homeostasis|calcium ion transport|transmembrane transport	calcium-transporting ATPase activity	fungal-type vacuole membrane|integral to membrane
YDR242W	YDR242W	AMD2	hom	Verified	0.711107305227946	0.238508871711653	no	1117	0.185931048608381	613	NA					Putative amidase	biological_process	amidase activity	cellular_component
YFL031W	YFL031W	HAC1	hom	Verified	0.710899253407447	0.238573334350932	no	1118	0.218864763291278	738	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|SIGNALING	NUCLEUS		Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog); regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway facilitates efficient Hac1p synthesis; protein abundance increases in response to DNA replication stress	endoplasmic reticulum unfolded protein response|positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response|negative regulation of transcription from RNA polymerase II promoter during meiosis|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity	nucleus
YHL002W	YHL002W	HSE1	hom	Verified	0.710414737717969	0.238723493329942	no	1119	0.250231468581836	828	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT			Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes	late endosome to vacuole transport|protein targeting to vacuole	ubiquitin binding	endosome|ESCRT-0 complex
YGL041C_d	YGL041C	YGL041C	hom	Dubious	0.709765517028279	0.238924777998632	no	1120	0.251458130650838	864	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPL026C	YPL026C	SKS1	hom	Verified	0.707162987017013	0.239732598482302	no	1121	0.178253892738456	614	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN PHOSPHORYLATION	NUCLEUS		Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway	glucose transport|protein phosphorylation|response to glucose stimulus|positive regulation of transcription from RNA polymerase II promoter	protein serine/threonine kinase activity|protein kinase activity	nucleus|cytoplasm
YLR262C	YLR262C	YPT6	hom	Verified	0.703920900453656	0.240741017376759	no	1122	0.334370361796245	1132	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING	GOLGI APPARATUS|PLASMA MEMBRANE		Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6	intracellular protein transport|retrograde transport, endosome to Golgi	GTPase activity	Golgi apparatus
YDR132C	YDR132C	YDR132C	hom	Verified	0.703407622718752	0.24090087872355	no	1123	0.235909485019004	763	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	NUCLEUS|PLASMA MEMBRANE		Protein of unknown function; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; YDR132C has a paralog, YLR108C, that arose from the whole genome duplication	biological_process	molecular_function	nucleus|cytoplasm
YPR044C_d	YPR044C	OPI11	hom	Dubious	0.702900140661156	0.241058991748726	no	1124	0.240940040415988	825	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RPL43A/YPR043W; deletion confers sensitivity to GSAO	Unknown	Unknown	Unknown
YBR275C	YBR275C	RIF1	hom	Verified	0.702402762737148	0.241214011428928	no	1125	0.225745525246608	756	NA	FT	CELL CYCLE|GENE SILENCING	NUCLEUS|CHROMOSOME		Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation	telomere capping|telomere maintenance|chromatin silencing at silent mating-type cassette	telomeric DNA binding	nuclear telomere cap complex
YPL154C	YPL154C	PEP4	hom	Verified	0.702302119089953	0.241245386009315	no	1126	0.25208340300491	885	NA	FT	MEMBRANE ORGANIZATION|PROTEOLYSIS|RESPONSE TO NUTRIENT LEVELS	MITOCHONDRION		Vacuolar aspartyl protease (proteinase A), required for the posttranslational precursor maturation of vacuolar proteinases; important for protein turnover after oxidative damage; synthesized as a zymogen, self-activates	microautophagy|proteolysis involved in cellular protein catabolic process|cellular response to starvation	peptidase activity	fungal-type vacuole lumen|mitochondrion|fungal-type vacuole
YDR363W	YDR363W	ESC2	hom	Verified	0.701998661608804	0.241339999056414	no	1127	0.265649441227175	905	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|GENE SILENCING	NUCLEUS		Sumo-like domain protein; prevents accumulation of toxic intermediates during replication-associated recombinational repair; roles in silencing, lifespan, chromatid cohesion and the intra-S-phase DNA damage checkpoint; RENi family member	intra-S DNA damage checkpoint|double-strand break repair via homologous recombination|chromatin silencing at silent mating-type cassette|mitotic sister chromatid cohesion	molecular_function	nucleus
YOR010C	YOR010C	TIR2	hom	Verified	0.70178064496823	0.241407985499294	no	1128	0.212574837665467	693	NA					Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis	response to stress	molecular_function	fungal-type cell wall
YPR073C	YPR073C	LTP1	hom	Verified	0.701626467503622	0.241456070574029	no	1129	0.224387989924377	785	NA	FT		NUCLEUS		Protein phosphotyrosine phosphatase of unknown cellular role; activated by adenine	protein dephosphorylation	protein tyrosine phosphatase activity	nucleus|cytoplasm
YDR317W	YDR317W	HIM1	hom	Verified	0.701464717849339	0.241506522864822	no	1130	0.220095857596852	743	NA	FT	RESPONSE TO DNA DAMAGE			Protein of unknown function involved in DNA repair	DNA repair	molecular_function	cellular_component
YJL157C	YJL157C	FAR1	hom	Verified	0.70114430774402	0.241606480776001	no	1131	0.19412633972916	654	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|SIGNALING|CELL DIVISION	NUCLEUS|SITE OF POLARIZED GROWTH		Cyclin-dependent kinase inhibitor; mediates cell cycle arrest in response to pheromone; also forms a complex with Cdc24p, Ste4p, and Ste18p that may specify the direction of polarized growth during mating; potential Cdc28p substrate; relocalizes from nucleus to cytoplasm upon DNA replication stress	maintenance of protein location in nucleus|pheromone-dependent signal transduction involved in conjugation with cellular fusion|cell cycle arrest in response to pheromone	cyclin-dependent protein kinase inhibitor activity	nucleus|mating projection tip|membrane|cytoplasm
YNL120C_d	YNL120C	YNL120C	hom	Dubious	0.700779723905231	0.241720246823587	no	1132	0.229158222232587	819	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; deletion enhances replication of Brome mosaic virus in S. cerevisiae, but likely due to effects on the overlapping gene	Unknown	Unknown	Unknown
YMR312W	YMR312W	ELP6	hom	Verified	0.70053608276026	0.241796289684613	no	1133	0.247843401201575	844	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity	protein urmylation|regulation of transcription from RNA polymerase II promoter|tRNA wobble uridine modification	ATPase activity|tRNA binding	Elongator holoenzyme complex
YPR189W	YPR189W	SKI3	hom	Verified	0.700084036254996	0.241937412343729	no	1134	0.219620029243147	765	NA	FT		NUCLEUS		Ski complex component and TPR protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay	nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, non-stop decay	molecular_function	Ski complex
YLR050C_p	YLR050C	YLR050C	hom	Uncharacterized	0.699765906646377	0.242036754782174	no	1135	0.235967898776338	808	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLR050C is not an essential gene	biological_process	molecular_function	integral to membrane|endoplasmic reticulum
YER039C-A_p	YER039C-A	YER039C-A	hom	Uncharacterized	0.699662086159261	0.242069179627192	no	1136	0.23824492321682	814	NA					Putative protein of unknown function; YER039C-A is not an essential gene	biological_process	molecular_function	integral to membrane
YPL038W-A_p	YPL038W-A	YPL038W-A	hom	Uncharacterized	0.69957156402836	0.242097453099106	no	1137	0.218731322533664	728	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YMR139W	YMR139W	RIM11	hom	Verified	0.69908955049611	0.242248034233298	no	1138	0.200695495944561	687	NA	FT	PROTEOLYSIS|PROTEIN PHOSPHORYLATION			Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress	proteolysis|ascospore formation|protein phosphorylation|response to stress	protein serine/threonine kinase activity|protein kinase activity	cytoplasm
YNL220W	YNL220W	ADE12	hom	Verified	0.69893410092001	0.242296607538757	no	1139	0.228531948947546	736	NA	FT	NUCLEOTIDE METABOLISM			Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence	purine nucleotide biosynthetic process	DNA replication origin binding|adenylosuccinate synthase activity	cytoplasm
YFL055W	YFL055W	AGP3	hom	Verified	0.698510654414609	0.24242894857161	no	1140	0.232516052707695	792	NA	FT		PLASMA MEMBRANE		Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition	amino acid transport|transmembrane transport	amino acid transmembrane transporter activity	integral to membrane|plasma membrane
YGR281W	YGR281W	YOR1	hom	Verified	0.696444110543634	0.243075373382215	no	1141	0.256234821565088	883	NA	FT	NUCLEOTIDE METABOLISM	PLASMA MEMBRANE		Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter mediates export of many different organic anions including oligomycin; similar to human cystic fibrosis transmembrane receptor (CFTR)	transport|response to drug	xenobiotic-transporting ATPase activity	integral to membrane|plasma membrane
YNL104C	YNL104C	LEU4	hom	Verified	0.695870040599422	0.243255110507023	no	1142	0.213593289646759	713	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway; LEU4 has a paralog, LEU9, that arose from the whole genome duplication	leucine biosynthetic process	2-isopropylmalate synthase activity	mitochondrion|cytoplasm
YBL087C	YBL087C	RPL23A	hom	Verified	0.692435276939296	0.244332009248934	no	1143	0.261150053782998	871	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L23A; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23A has a paralog, RPL23B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YIL045W	YIL045W	PIG2	hom	Verified	0.69221636035611	0.244400732989263	no	1144	0.228484662095875	781	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Putative type-1 protein phosphatase targeting subunit that tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase	regulation of glycogen biosynthetic process	protein phosphatase type 1 regulator activity	cytoplasm
YMR173W	YMR173W	DDR48	hom	Verified	0.691830910778892	0.244521761179246	no	1145	0.224786161955925	740	NA	FT	RESPONSE TO DNA DAMAGE			DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress	DNA repair	ATPase activity|GTPase activity	cytoplasm
YGR004W	YGR004W	PEX31	hom	Verified	0.691466105169718	0.24463633705441	no	1146	0.211394687755532	726	NA	FT	PEROXISOME ORGANIZATION			Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex30p and Pex32p; probably acts at a step downstream of steps mediated by Pex28p and Pex29p	peroxisome organization	molecular_function	integral to membrane|integral to peroxisomal membrane
YHR028C	YHR028C	DAP2	hom	Verified	0.690763373924601	0.244857127973451	no	1147	0.267128710942151	905	NA	FT	PROTEOLYSIS			Dipeptidyl aminopeptidase, synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p	protein processing	dipeptidyl-peptidase activity	fungal-type vacuole membrane
YIL007C	YIL007C	NAS2	hom	Verified	0.688491682158008	0.245571603250373	no	1148	0.216831768658282	757	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS	NUCLEUS		Proteasome-interacting protein; involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); similar to mammalian proteasomal modulator subunit; non-essential gene; interacts with Rpn4p; protein abundance increases in response to DNA replication stress	proteasome regulatory particle assembly|ubiquitin-dependent protein catabolic process	molecular_function	cytosol|nucleus|cytoplasm
YOR267C	YOR267C	HRK1	hom	Verified	0.688467306913016	0.245579275635438	no	1149	0.205977980168421	678	NA	FT	ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS			Protein kinase; implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis; protein abundance increases in response to DNA replication stress	protein phosphorylation|cellular ion homeostasis	protein serine/threonine kinase activity|protein kinase activity	cytoplasm
YGR058W	YGR058W	PEF1	hom	Verified	0.688088504222441	0.245698524629022	no	1150	0.231883817380186	798	NA	FT	CELL CYCLE|CELL DIVISION	NUCLEUS|SITE OF POLARIZED GROWTH		Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly	bipolar cellular bud site selection|regulation of COPII vesicle coating|axial cellular bud site selection	zinc ion binding|calcium ion binding	cytosol|site of polarized growth|nucleus|cellular bud neck|cytoplasm
YOR374W	YOR374W	ALD4	hom	Verified	0.687423197777941	0.245908041686311	no	1151	0.234515434513537	798	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed	NADPH regeneration|ethanol metabolic process|pyruvate metabolic process|acetate biosynthetic process	aldehyde dehydrogenase [NAD(P)+] activity|aldehyde dehydrogenase (NAD) activity	mitochondrial nucleoid|mitochondrion
YOR308C	YOR308C	SNU66	hom	Verified	0.68651246594615	0.246195003035423	no	1152	0.246685712827081	867	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Component of the U4/U6.U5 snRNP complex involved in pre-mRNA splicing via spliceosome; also required for pre-5S rRNA processing and may act in concert with Rnh70p; has homology to human SART-1	maturation of 5S rRNA|mRNA splicing, via spliceosome	molecular_function	U4/U6 x U5 tri-snRNP complex
YFL003C	YFL003C	MSH4	hom	Verified	0.686316077924018	0.246256906218208	no	1153	0.210361085176913	673	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Protein involved in meiotic recombination, required for normal levels of crossing over, colocalizes with Zip2p to discrete foci on meiotic chromosomes, has homology to bacterial MutS protein	reciprocal meiotic recombination	DNA binding	nuclear chromosome
YJR039W_p	YJR039W	YJR039W	hom	Uncharacterized	0.686303421162413	0.246260896023845	no	1154	0.208281034184556	738	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YGR168C_p	YGR168C	YGR168C	hom	Uncharacterized	0.686272361636337	0.246270687101143	no	1155	0.28176450014019	998	NA					Putative protein of unknown function; YGR168C is not an essential gene	biological_process	molecular_function	integral to membrane
YNR048W	YNR048W	YNR048W	hom	Verified	0.685844486511712	0.246405589935022	no	1156	0.247952277184086	857	NA					Protein that interacts with phospholipid translocase (flippase) Dnf3p; YNR048W has a paralog, CDC50, that arose from the whole genome duplication	response to drug	phospholipid-translocating ATPase activity	integral to membrane
YIL148W	YIL148W	RPL40A	hom	Verified	0.685701988487025	0.24645052628922	no	1157	0.253879013938758	853	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RESPONSE TO DNA DAMAGE|TRANSLATION	NUCLEUS	RIBOSOME	Ubiquitin-ribosomal 60S subunit protein L40A fusion protein; cleaved to yield ubiquitin and ribosomal protein L40A; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40A has a paralog, RPL40B, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress	cytoplasmic translation|protein ubiquitination|ribosome biogenesis	structural constituent of ribosome|protein tag	cytosolic large ribosomal subunit
YHR131C_p	YHR131C	YHR131C	hom	Uncharacterized	0.68491966309054	0.246697308633607	no	1158	0.220785061866278	731	NA					Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; overexpression causes cell cycle delay or arrest; contains a PH domain and binds phosphatidylinositols and other lipids in a large-scale study	biological_process	molecular_function	cytoplasm
YMR292W	YMR292W	GOT1	hom	Verified	0.68483072969033	0.246725370798575	no	1159	0.226808143065467	788	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Homodimeric protein that is packaged into COPII vesicles and cycles between the ER and Golgi; involved in secretory transport but not directly required for aspects of transport assayed in vitro; may influence membrane composition	ER to Golgi vesicle-mediated transport|Golgi to endosome transport	molecular_function	integral to membrane|endoplasmic reticulum|Golgi apparatus|ER to Golgi transport vesicle|Golgi membrane
YKR056W	YKR056W	TRM2	hom	Verified	0.68469514082178	0.246768157982188	no	1160	0.239304281437894	846	NA	FT	RNA PROCESSING|RESPONSE TO DNA DAMAGE			tRNA methyltransferase, 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation; endo-exonuclease with a role in DNA repair	double-strand break repair|DNA repair|tRNA modification	tRNA (m5U54) methyltransferase activity|double-stranded DNA specific 5'-3' exodeoxyribonuclease activity|single-stranded DNA specific endodeoxyribonuclease activity	cellular_component
YDL054C	YDL054C	MCH1	hom	Verified	0.683845274899478	0.247036436903557	no	1161	0.252669942085317	878	NA					Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport	transport	monocarboxylic acid transmembrane transporter activity|transporter activity	integral to membrane|membrane
YPL030W	YPL030W	TRM44	hom	Verified	0.681822553832781	0.247675580561002	no	1162	0.229545577226935	786	NA	FT	RNA PROCESSING			tRNA(Ser) Um(44) 2'-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS(CGA) and tS(UGA); conserved among metazoans and fungi but there does not appear to be a homolog in plants; TRM44 is a non-essential gene	tRNA methylation	tRNA (uracil) methyltransferase activity	cytoplasm
YJR129C_p	YJR129C	YJR129C	hom	Uncharacterized	0.681200683673173	0.247872257747852	no	1163	0.232395350509784	827	NA					Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	S-adenosylmethionine-dependent methyltransferase activity	cytoplasm
YPL109C_p	YPL109C	YPL109C	hom	Uncharacterized	0.680890418766142	0.247970415550487	no	1164	0.232725072397169	816	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YJR078W	YJR078W	BNA2	hom	Verified	0.679690774839177	0.248350139238244	no	1165	0.224858025400866	763	NA	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for de novo biosynthesis of NAD from tryptophan via kynurenine; interacts genetically with telomere capping gene CDC13; regulated by Hst1p and Aftp	de novo NAD biosynthetic process from tryptophan	tryptophan 2,3-dioxygenase activity|indoleamine 2,3-dioxygenase activity	cytoplasm
YMR244C-A	YMR244C-A	COA6	hom	Verified	0.67960851902718	0.248376187048231	no	1166	0.234306759136474	810	NA	FT		NUCLEUS|MITOCHONDRION		Protein involved in cytochrome c oxidase assembly; also required for efficient formation of respiratory supercomplexes comprised of Complexes III and IV; localizes to the mitochondrial intermembrane space; has a human homolog; transcription is induced in response to the DNA-damaging agent MMS; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YDR277C	YDR277C	MTH1	hom	Verified	0.679412158661915	0.248438374042654	no	1167	0.242039783464729	786	NA	FT	SIGNALING			Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation	glucose transport|signal transduction	molecular_function	cellular_component
YDR441C	YDR441C	APT2	hom	Verified	0.679133395383896	0.24852667214956	no	1168	0.24171587863344	814	NA					Potential adenine phosphoribosyltransferase; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity; APT2 has a paralog, APT1, that arose from the whole genome duplication	biological_process	adenine phosphoribosyltransferase activity|molecular_function	cytoplasm
YLR390W	YLR390W	ECM19	hom	Verified	0.679115331002322	0.248532394608783	no	1169	0.275219615819926	982	NA	FT	CELL WALL ORG/BIOGENESIS	MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	fungal-type cell wall organization	molecular_function	mitochondrion
YDR539W	YDR539W	FDC1	hom	Verified	0.679093455952317	0.248539324310683	no	1170	0.241133827618829	842	NA	FT	KETONE METABOLISM|COFACTOR METABOLISM	PLASMA MEMBRANE		Putative phenylacrylic acid decarboxylase; essential for the decarboxylation of aromatic carboxylic acids to the corresponding vinyl derivatives; homolog of E. coli UbiD; GFP-fusion protein localizes to the cytoplasm	cinnamic acid catabolic process	molecular_function	cytoplasm
YBR042C	YBR042C	CST26	hom	Verified	0.679077232029689	0.248544463883019	no	1171	0.235384347983647	838	NA	FT	LIPID METABOLISM			Putative transferase involved in phospholipid biosynthesis; required for incorporation of stearic acid into phosphatidylinositol; affects chromosome stability when overexpressed; CST26 has a paralog, YDR018C, that arose from the whole genome duplication	phospholipid biosynthetic process	transferase activity, transferring acyl groups	lipid particle
YER091C	YER091C	MET6	hom	Verified	0.678981257526404	0.248574868779819	no	1172	0.171542736428199	582	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Cobalamin-independent methionine synthase, involved in methionine biosynthesis and regeneration; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs	methionine biosynthetic process	5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity	plasma membrane|cytoplasm
YBL015W	YBL015W	ACH1	hom	Verified	0.677780661716914	0.248955387087769	no	1173	0.231324867412567	763	NA	FT	KETONE METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth	acetate metabolic process	acetate CoA-transferase activity|acetyl-CoA hydrolase activity	cytosol|mitochondrion
YER109C	YER109C	FLO8	hom	Verified	0.676614364495064	0.249325331383382	no	1174	0.22843534542882	749	NA	FT	TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM	NUCLEUS		Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this gene	biofilm formation|Unknown|positive regulation of starch catabolic process by positive regulation of transcription from RNA polymerase II promoter|positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|cytoplasm
YGL037C	YGL037C	PNC1	hom	Verified	0.676369902797931	0.249402910579556	no	1175	0.225017248649398	755	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|GENE SILENCING	NUCLEUS		Nicotinamidase that converts nicotinamide to nicotinic acid; part of the NAD(+) salvage pathway; required for life span extension by calorie restriction; PNC1 expression responds to all known stimuli that extend replicative life span; protein increases in abundance and relative distribution to cytoplasmic foci decreases upon DNA replication stress	replicative cell aging|chromatin silencing at rDNA|nicotinate nucleotide salvage|chromatin silencing at telomere	nicotinamidase activity	nucleus|peroxisome|cytoplasm
YBR098W	YBR098W	MMS4	hom	Verified	0.676074839338136	0.249496565181585	no	1176	0.238430689231578	846	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS		Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p	DNA repair|DNA topological change|regulation of reciprocal meiotic recombination|reciprocal meiotic recombination|resolution of meiotic recombination intermediates|response to DNA damage stimulus	transcription coactivator activity|endonuclease activity|crossover junction endodeoxyribonuclease activity	Holliday junction resolvase complex|nucleus
YAL046C	YAL046C	AIM1	hom	Verified	0.674490759476595	0.249999679274407	no	1177	0.258794135756274	898	NA					Protein involved in mitochondrial function or organization; null mutant displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	cellular_component
YOR242C	YOR242C	SSP2	hom	Verified	0.674220069697293	0.250085705938165	no	1178	0.231198346304168	772	NA	FT	CELL WALL ORG/BIOGENESIS			Sporulation specific protein that localizes to the spore wall; required for sporulation at a point after meiosis II and during spore wall formation; SSP2 expression is induced midway in meiosis	ascospore wall assembly|ascospore formation	molecular_function	ascospore wall
YER169W	YER169W	RPH1	hom	Verified	0.673500788887126	0.250314373522912	no	1179	0.263075606430366	936	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS		JmjC domain-containing histone demethylase; specifically demethylates H3K36 tri- and dimethyl modification states; associates with actively transcribed (RNA polymerase II) regions in vivo and specifically targets H3K36 in its trimethylation state as its substrate; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway; RPH1 has a paralog, GIS1, that arose from the whole genome duplication	negative regulation of transcription from RNA polymerase II promoter|histone demethylation	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|sequence-specific DNA binding|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)	nucleus
YDL241W_p	YDL241W	YDL241W	hom	Uncharacterized	0.672644900179689	0.250586614678817	no	1180	0.235021252248882	785	NA					Putative protein of unknown function; YDL241W is not an essential gene	biological_process	molecular_function	cellular_component
YOL055C	YOL055C	THI20	hom	Verified	0.672450872969737	0.250648352673763	no	1181	0.231656165864008	790	NA					Trifunctional enzyme of thiamine biosynthesis, degradation and salvage; has hydroxymethylpyrimidine (HMP) kinase, HMP-phosphate (HMP-P) kinase and thiaminase activities; member of a gene family with THI21 and THI22; HMP and HMP-P kinase activity redundant with Thi21p	thiamine biosynthetic process|thiamine catabolic process	phosphomethylpyrimidine kinase activity|thiaminase activity|hydroxymethylpyrimidine kinase activity	cytosol
YMR090W_p	YMR090W	YMR090W	hom	Uncharacterized	0.672366179793234	0.250675303929494	no	1182	0.263316370887415	909	NA					Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; GFP-fusion protein localizes to the cytoplasm; up-regulated in response to the fungicide mancozeb; not essential for viability	biological_process	molecular_function	cytoplasm
YGR279C	YGR279C	SCW4	hom	Verified	0.672256843776413	0.250710099355641	no	1183	0.257335560607444	868	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating	conjugation with cellular fusion	glucosidase activity	extracellular region|fungal-type cell wall
YMR080C	YMR080C	NAM7	hom	Verified	0.670496384116888	0.251270705355426	no	1184	0.268959484368919	906	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|RNA LOCALIZATION|GENE SILENCING	NUCLEUS		ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance; forms cytoplasmic foci upon DNA replication stress	nuclear-transcribed mRNA catabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|intracellular mRNA localization|translational frameshifting|regulation of translational termination|chromatin silencing at silent mating-type cassette|protein ubiquitination	RNA-dependent ATPase activity|ATP-dependent RNA helicase activity|nucleic acid binding	mitochondrion|polysome|cytoplasm
YML103C	YML103C	NUP188	hom	Verified	0.670004885499071	0.251427337907865	no	1185	0.232928600411105	810	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188	nuclear pore organization|protein import into nucleus|mRNA export from nucleus in response to heat stress	structural constituent of nuclear pore	integral to membrane|nuclear pore|nuclear pore inner ring
YHR134W	YHR134W	WSS1	hom	Verified	0.669665170723599	0.25153562959048	no	1186	0.198470248685495	714	NA	FT	RESPONSE TO DNA DAMAGE	ENDOMEMBRANE SYSTEM|NUCLEUS		Sumoylated protein that localizes to a single spot on the nuclear periphery of mother cells but not daughters; interacts genetically with SMT3; UV-sensitive mutant phenotype and genetic interactions suggest a role in the DNA damage response	protein sumoylation|response to UV-B|response to UV-C|response to DNA damage stimulus	molecular_function	nuclear envelope
YPL194W	YPL194W	DDC1	hom	Verified	0.669361669299816	0.251632398296451	no	1187	0.239185133279272	813	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		DNA damage checkpoint protein; part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate; forms nuclear foci upon DNA replication stress	meiosis|mitotic cell cycle G1/S transition checkpoint|intra-S DNA damage checkpoint|recombinational repair|G2/M transition checkpoint|cell cycle checkpoint	molecular_function	condensed nuclear chromosome|checkpoint clamp complex
YKL171W	YKL171W	NNK1	hom	Verified	0.669328502599463	0.25164297439304	no	1188	0.220526522494076	738	NA	FT	PROTEOLYSIS|PROTEIN PHOSPHORYLATION			Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm	proteolysis|protein phosphorylation	protein kinase activity	cytoplasm
YIL120W	YIL120W	QDR1	hom	Verified	0.669006437054965	0.251745685883277	no	1189	0.235236674458405	803	NA	FT		PLASMA MEMBRANE		Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for resistance to quinidine, ketoconazole, fluconazole, and barban; QDR1 has a paralog, AQR1, that arose from the whole genome duplication	drug transmembrane transport	drug transmembrane transporter activity	integral to membrane|plasma membrane
YGR080W	YGR080W	TWF1	hom	Verified	0.668913511341072	0.251775325389516	no	1190	0.240715127274697	861	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Twinfilin, highly conserved actin monomer-sequestering protein involved in regulation of the cortical actin cytoskeleton, composed of two cofilin-like regions, localizes actin monomers to sites of rapid filament assembly	bipolar cellular bud site selection|actin polymerization or depolymerization|sequestering of actin monomers	actin monomer binding	mating projection tip|actin cortical patch
YGL197W	YGL197W	MDS3	hom	Verified	0.667165237553345	0.252333296543935	no	1191	0.276532131432841	945	NA	FT	CELL CYCLE|SIGNALING	MITOCHONDRION		Putative component of the TOR regulatory pathway; negative regulator of early meiotic gene expression; required, with Pmd1p, for growth under alkaline conditions; has an N-terminal kelch-like domain	TOR signaling cascade|negative regulation of sporulation resulting in formation of a cellular spore	molecular_function	mitochondrion|cytoplasm
YMR150C	YMR150C	IMP1	hom	Verified	0.665651325045855	0.252816996146594	no	1192	0.238989140910472	777	NA	FT	PROTEIN LOCALIZATION|PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p	protein processing involved in protein targeting to mitochondrion	endopeptidase activity	mitochondrion|mitochondrial inner membrane peptidase complex
YDR534C	YDR534C	FIT1	hom	Verified	0.664766161453684	0.253100034550245	no	1193	0.202354948798285	677	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall	siderophore transport	molecular_function	fungal-type cell wall
YBR147W	YBR147W	RTC2	hom	Verified	0.663024428796461	0.253657454325128	no	1194	0.232300191904479	791	NA	FT		MITOCHONDRION		Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; positive regulation by Lys14p suggests that lysine may be the primary substrate; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter	biological_process	molecular_function	mitochondrion|integral to membrane
YDL036C	YDL036C	PUS9	hom	Verified	0.662626877564764	0.253784775948213	no	1195	0.23458517920133	767	NA	FT	RNA PROCESSING	NUCLEUS|MITOCHONDRION		Mitochondrial tRNA:pseudouridine synthase, catalyzes the formation of pseudouridine at position 32 in mitochondrial tRNAs; contains an N-terminal mitochondrial targeting sequence	tRNA pseudouridine synthesis	pseudouridine synthase activity	mitochondrion|nucleus|cytoplasm
YKL197C	YKL197C	PEX1	hom	Verified	0.661435605769499	0.254166499057904	no	1196	0.249902646321613	867	NA	FT	PROTEIN LOCALIZATION|SIGNALING|PEROXISOME ORGANIZATION			AAA-peroxin that heterodimerizes with AAA-peroxin Pex6p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; induced by oleic acid and upregulated during anaerobiosis	protein import into peroxisome matrix, receptor recycling	ATPase activity|protein heterodimerization activity	peroxisomal membrane|peroxisome
YGR210C_p	YGR210C	YGR210C	hom	Uncharacterized	0.660856721784258	0.254352101396521	no	1197	0.238787693261481	811	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YMR118C_p	YMR118C	SHH3	hom	Uncharacterized	0.660826489423483	0.254361796476638	no	1198	0.23467424187295	782	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Putative mitochondrial inner membrane protein of unknown function; although similar to Sdh3p, Shh3p is not a stoichiometric subunit of either succinate dehydrogenase or of the TIM22 translocase	biological_process	molecular_function	integral to membrane
YBL011W	YBL011W	SCT1	hom	Verified	0.660658132995848	0.254415789486452	no	1199	0.250592255288245	878	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase of the glycerolipid biosynthesis pathway, prefers 16-carbon fatty acids, similar to Gpt2p, gene is constitutively transcribed	phospholipid biosynthetic process	glycerol-3-phosphate O-acyltransferase activity|glycerone-phosphate O-acyltransferase activity	integral to membrane|endoplasmic reticulum
YPR150W_d	YPR150W	YPR150W	hom	Dubious	0.66061918132498	0.254428282398137	no	1200	0.225740247800499	769	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SUE1/YPR151C	Unknown	Unknown	Unknown
YIL086C_d	YIL086C	YIL086C	hom	Dubious	0.660443854523294	0.254484518683389	no	1201	0.239541642806805	824	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR289W	YLR289W	GUF1	hom	Verified	0.659541909614976	0.254773921511484	no	1202	0.264900808606264	891	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM	MITOCHONDRION	RIBOSOME	Mitochondrial matrix GTPase that associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in translational fidelity; similar to bacterial LepA elongation factor	positive regulation of translation	ribosome binding|GTPase activity	mitochondrion|mitochondrial ribosome|mitochondrial matrix
YAL020C	YAL020C	ATS1	hom	Verified	0.658613842053828	0.25507188595323	no	1203	0.262651231317878	913	NA	FT	RNA PROCESSING|CELL DIVISION|CYTOSKELETON ORGANIZATION			Protein required, with Elongator complex, Kti11p, and Kti12p, for modification of wobble nucleosides in tRNA; has a potential role in regulatory interactions between microtubules and the cell cycle	microtubule-based process|budding cell bud growth|microtubule cytoskeleton organization|tRNA wobble uridine modification	molecular_function	cytoplasm
YNL140C_p	YNL140C	YNL140C	hom	Uncharacterized	0.658303609380865	0.255171529580321	no	1204	0.299305125571096	1014	NA					Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps THO2/YNL139C	biological_process	molecular_function	cellular_component
YBR065C	YBR065C	ECM2	hom	Verified	0.657991552366672	0.255271779699429	no	1205	0.241438277293826	818	NA	FT	RNA PROCESSING	NUCLEUS		Pre-mRNA splicing factor, facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p	mRNA splicing, via spliceosome	molecular_function	nucleus
YFR013W	YFR013W	IOC3	hom	Verified	0.657261893721348	0.255506267090357	no	1206	0.300226494640242	1019	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS		Subunit of the Isw1a complex; Isw1a has nucleosome-stimulated ATPase activity and represses transcription initiation by specific positioning of a promoter proximal dinucleosome; IOC3 has a paralog, ESC8, that arose from the whole genome duplication	chromatin remodeling	nucleosome binding|ATPase activity|DNA binding	ISW1 complex
YDR108W	YDR108W	TRS85	hom	Verified	0.656378951673523	0.255790164937965	no	1207	0.295196401366025	1015	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION	GOLGI APPARATUS		Subunit of TRAPPIII (transport protein particle), a multimeric guanine nucleotide-exchange factor for Ypt1p, required for membrane expansion during autophagy and the CVT pathway; directs Ypt1p to the PAS; late post-replication meiotic role	meiosis|vesicle organization|piecemeal microautophagy of nucleus|ER to Golgi vesicle-mediated transport|peroxisome degradation|macroautophagy|protein localization to pre-autophagosomal structure|CVT pathway	molecular_function	TRAPP complex|pre-autophagosomal structure
YJR137C	YJR137C	MET5	hom	Verified	0.655552879102695	0.256055926211348	no	1208	0.204693640035546	679	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS			Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine	fungal-type cell wall organization|sulfate assimilation	sulfite reductase (NADPH) activity	sulfite reductase complex (NADPH)|cytoplasm
YBL017C	YBL017C	PEP1	hom	Verified	0.655075402130616	0.25620960414655	no	1209	0.22412320916381	752	NA	FT	PROTEIN LOCALIZATION|VACUOLAR TRANSPORT	GOLGI APPARATUS		Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments	vacuolar transport|protein targeting to vacuole	signal sequence binding	integral to membrane|Golgi apparatus
YGL034C_d	YGL034C	YGL034C	hom	Dubious	0.654444666635033	0.256412682665631	no	1210	0.273189221288579	910	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKL064W	YKL064W	MNR2	hom	Verified	0.652023332681703	0.257193060250146	no	1211	0.250920203055567	862	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Vacuolar membrane protein required for magnesium homeostasis; putative magnesium transporter; has similarity to Alr1p and Alr2p, which mediate influx of Mg2+ and other divalent cations	cellular magnesium ion homeostasis	magnesium ion transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane
YDR191W	YDR191W	HST4	hom	Verified	0.651310959027073	0.257422887741455	no	1212	0.257588620796535	885	NA	FT	KETONE METABOLISM|LIPID METABOLISM|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS		Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism	short-chain fatty acid metabolic process|chromatin silencing at telomere|histone deacetylation	histone deacetylase activity|DNA binding	nucleus|cytoplasm
YGL249W	YGL249W	ZIP2	hom	Verified	0.650940517067204	0.257542442665243	no	1213	0.221722368769547	726	NA	FT	CELL CYCLE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Meiosis-specific protein; involved in normal synaptonemal complex formation and pairing between homologous chromosomes during meiosis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress	synaptonemal complex assembly|synapsis|reciprocal meiotic recombination	molecular_function	synaptonemal complex
YPL261C_d	YPL261C	YPL261C	hom	Dubious	0.650814156621923	0.257583230314139	no	1214	0.255503185878769	891	NA					Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YPL260W	Unknown	Unknown	Unknown
YKR084C	YKR084C	HBS1	hom	Verified	0.650610121191399	0.257649097605428	no	1215	0.26504401763698	906	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM			GTPase with similarity to translation release factors; together with binding partner Dom34p, facilitates ribosomal subunit dissociation and peptidyl-tRNA release when translation is stalled; genetically implicated in mRNA no-go decay	nuclear-transcribed mRNA catabolic process, no-go decay|ribosome disassembly|nonfunctional rRNA decay	ribosome binding|GTPase activity	cytoplasm
YIL020C	YIL020C	HIS6	hom	Verified	0.650139888756101	0.257800932658367	no	1216	0.254693825029066	881	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Phosphoribosyl-5-amino-1-phosphoribosyl-4-imidazolecarboxiamide isomerase, catalyzes the fourth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts	histidine biosynthetic process	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity	intracellular
YGR049W	YGR049W	SCM4	hom	Verified	0.650041454823016	0.257832722224242	no	1217	0.266221152965016	882	NA	FT		MITOCHONDRION		Mitochondrial outer membrane protein of unknown function; predicted to have 4 transmembrane segments; import is mediated by Tom70p and Mim1p; interacts genetically with a cdc4 mutation	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion|integral to membrane
YKL079W	YKL079W	SMY1	hom	Verified	0.646853007441721	0.258863540984689	no	1218	0.234350978592138	770	NA	FT	VESICLE-MEDIATED TRANSPORT	SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein that interacts with Myo2p, proposed to be involved in exocytosis; N-terminal domain is related to the motor domain of kinesins	exocytosis	motor activity	incipient cellular bud site|cellular bud neck|mating projection tip|cellular bud tip
YAL005C	YAL005C	SSA1	hom	Verified	0.646176603855134	0.259082494769265	no	1219	0.222897525431897	765	NA	FT	PROTEIN LOCALIZATION|TRANSLATION|MITOCHONDRION ORGANIZATION	NUCLEUS		ATPase involved in protein folding and NLS-directed nuclear transport; member of HSP70 family; forms chaperone complex with Ydj1p; localized to nucleus, cytoplasm, and cell wall; 98% identical with paralog Ssa2p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes; general targeting factor of Hsp104p to prion fibrils	cytoplasmic translation|protein folding|protein refolding|protein targeting to mitochondrion|SRP-dependent cotranslational protein targeting to membrane, translocation|protein import into nucleus, translocation|response to stress	unfolded protein binding|ATPase activity	fungal-type vacuole membrane|fungal-type cell wall|plasma membrane|nucleus|polysome|chaperonin-containing T-complex|cytoplasm
YOL031C	YOL031C	SIL1	hom	Verified	0.645931941931068	0.25916171611342	no	1220	0.246918100109237	860	NA	FT	PROTEIN LOCALIZATION	ENDOPLASMIC RETICULUM		Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, required for protein translocation into the ER; homolog of Yarrowia lipolytica SLS1; GrpE-like protein	SRP-dependent cotranslational protein targeting to membrane, translocation	adenyl-nucleotide exchange factor activity	endoplasmic reticulum
YLR405W	YLR405W	DUS4	hom	Verified	0.644646138905442	0.259578263895773	no	1221	0.248356995613572	824	NA	FT	RNA PROCESSING|OXIDATION-REDUCTION PROCESS			Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p	tRNA modification	tRNA dihydrouridine synthase activity	cellular_component
YAL036C	YAL036C	RBG1	hom	Verified	0.643905895907015	0.25981822915717	no	1222	0.262611263030511	908	NA	FT	TRANSLATION		RIBOSOME	Member of the DRG family of GTP-binding proteins; associates with translating ribosomes; interacts with Tma46p, Ygr250cp, Gir2p and Yap1p via two-hybrid	cytoplasmic translation	GTP binding	polysomal ribosome|polysome|cytoplasm
YGL180W	YGL180W	ATG1	hom	Verified	0.642903750059765	0.26014327797714	no	1223	0.253622488286015	870	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Protein ser/thr kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for phagophore assembly site formation; during autophagy forms a complex with Atg13p and Atg17p	piecemeal microautophagy of nucleus|mitochondrion degradation|protein phosphorylation|CVT pathway|autophagic vacuole assembly	protein serine/threonine kinase activity|protein kinase activity	cytosol|pre-autophagosomal structure|Atg1p signaling complex
YDR122W	YDR122W	KIN1	hom	Verified	0.642893264508861	0.260146680102788	no	1224	0.23369358623957	780	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN PHOSPHORYLATION	PLASMA MEMBRANE		Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p	protein autophosphorylation|exocytosis|protein phosphorylation	protein serine/threonine kinase activity|protein kinase activity	internal side of plasma membrane|plasma membrane
YER111C	YER111C	SWI4	hom	Verified	0.642302888833238	0.260338269473358	no	1225	0.255744270415133	901	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE	NUCLEUS|CHROMOSOME		DNA binding component of the SBF complex (Swi4p-Swi6p); a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair; acetylation at two sites, K1016 and K1066, regulates interaction with Swi6p	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription involved in G1/S phase of mitotic cell cycle	sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	SBF transcription complex|nuclear chromatin
YPR018W	YPR018W	RLF2	hom	Verified	0.641799111958671	0.260501813164358	no	1226	0.25168032122678	845	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1); chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription	DNA replication-dependent nucleosome assembly	histone binding	chromosome, centromeric region|nucleus|CAF-1 complex
YNL239W	YNL239W	LAP3	hom	Verified	0.641669628205043	0.260543856689062	no	1227	0.249992813803049	852	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|PROTEOLYSIS	MITOCHONDRION		Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH	response to antibiotic|negative regulation of transcription from RNA polymerase II promoter|homocysteine catabolic process	double-stranded DNA binding|cysteine-type peptidase activity|mRNA binding|single-stranded DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding	mitochondrion|cytoplasm
YER115C	YER115C	SPR6	hom	Verified	0.6410817470453	0.260734786311298	no	1228	0.268925661216463	935	NA	FT	CELL CYCLE			Protein of unknown function, expressed during sporulation; not required for sporulation, but gene exhibits genetic interactions with other genes required for sporulation	ascospore formation	molecular_function	cellular_component
YPL004C	YPL004C	LSP1	hom	Verified	0.640647435772958	0.260875886365684	no	1229	0.248268822133246	852	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION	MITOCHONDRION		Primary component of eisosomes, which are large immobile patch structures at the cell cortex associated with endocytosis, along with Pil1p and Sur7p; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; member of the BAR domain family	negative regulation of protein kinase activity|endocytosis|response to heat	lipid binding	mitochondrial outer membrane|eisosome|mitochondrion|plasma membrane|cytoplasm
YKL184W	YKL184W	SPE1	hom	Verified	0.640512393135914	0.260919767334392	no	1230	0.261901389173882	896	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM			Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation	pantothenate biosynthetic process|putrescine biosynthetic process	ornithine decarboxylase activity	cytoplasm
YGL096W	YGL096W	TOS8	hom	Verified	0.639628804175859	0.261206975778764	no	1231	0.244823859076835	813	NA	FT		NUCLEUS|CHROMOSOME		Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication	biological_process	chromatin binding|sequence-specific DNA binding	nuclear chromatin
YPR117W_p	YPR117W	YPR117W	hom	Uncharacterized	0.639533395333996	0.261237997905984	no	1232	0.259670843118312	873	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YKR021W	YKR021W	ALY1	hom	Verified	0.638348638840139	0.261623378407775	no	1233	0.258125858993296	869	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION			Alpha arrestin that controls nutrient-mediated intracellular sorting of permease Gap1p; interacts with AP-1 subunit Apl4p; may regulate endocytosis of plasma membrane proteins by recruiting ubiquitin ligase Rsp5p to plasma membrane targets; ALY1 has a paralog, ALY2, that arose from the whole genome duplication	Unknown|regulation of intracellular transport|ubiquitin-dependent endocytosis	ubiquitin protein ligase binding	late endosome|cytoplasm|early endosome
YDR219C	YDR219C	MFB1	hom	Verified	0.63833293343328	0.261628489059964	no	1234	0.242022498956505	823	NA	FT	PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION	UBIQUITIN LIGASE COMPLEX	Mitochondria-associated F-box protein involved in maintenance of normal mitochondrial morphology; interacts with Skp1p through the F-box motif; preferentially localizes to the mother cell during budding	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|mitochondrion organization	molecular_function	extrinsic to mitochondrial outer membrane|SCF ubiquitin ligase complex
YFL020C	YFL020C	PAU5	hom	Verified	0.636353212054641	0.262273114651212	no	1235	0.244189617875283	831	NA					Member of the seripauperin multigene family encoded mainly in subtelomeric regions; induced during alcoholic fermentation; induced by low temperature and also by anaerobic conditions; negatively regulated by oxygen and repressed by heme	biological_process	molecular_function	integral to membrane|cytoplasm
YKL075C_p	YKL075C	YKL075C	hom	Uncharacterized	0.63605454025164	0.262370437043597	no	1236	0.272110428088106	928	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; proposed to be involved in resistance to streptozotocin and camptothecin	response to drug	molecular_function	cytoplasm
YMR039C	YMR039C	SUB1	hom	Verified	0.635163750087816	0.262660811363148	no	1237	0.247209221368008	838	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Transcriptional coactivator; facilitates elongation through factors that modify RNAP II; role in peroxide resistance involving Rad2p; role in the hyperosmotic stress response through polymerase recruitment at RNAP II and RNAP III genes; protein abundance increases in response to DNA replication stress	termination of RNA polymerase II transcription|hyperosmotic response|RNA polymerase III transcriptional preinitiation complex assembly|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase III promoter	transcription coactivator activity	nucleus
YER071C_p	YER071C	TDA2	hom	Uncharacterized	0.634815115146091	0.262774501998718	no	1238	0.254037031208795	831	NA	FT		SITE OF POLARIZED GROWTH		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele	biological_process	molecular_function	mating projection tip|cytoplasm
YPR171W	YPR171W	BSP1	hom	Verified	0.634570510727553	0.262854283069601	no	1239	0.266003062242426	899	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON		Adapter that links synaptojanins Inp52p and Inp53p to the cortical actin cytoskeleton	actin cortical patch localization	protein binding, bridging	mating projection tip|membrane|cellular bud neck|actin cortical patch|cellular bud tip
YDL018C	YDL018C	ERP3	hom	Verified	0.634565208334847	0.262856012654532	no	1240	0.277450673741666	915	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport	vesicle-mediated transport	molecular_function	integral to membrane
YGR111W_p	YGR111W	YGR111W	hom	Uncharacterized	0.634506319696869	0.262875221902292	no	1241	0.294448202462826	1004	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	regulation of cell size	molecular_function	nucleus|cytoplasm
YDR095C_d	YDR095C	YDR095C	hom	Dubious	0.634387287486547	0.262914051944262	no	1242	0.267419333365393	878	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR152W	YDR152W	GIR2	hom	Verified	0.63246443338355	0.263541721025857	no	1243	0.268298367880067	910	NA	FT	TRANSLATION			Highly-acidic cytoplasmic RWD domain-containing protein of unknown function; forms a complex with Rbg2p; interacts with Rbg1p and Gcn1p; associates with translating ribosomes; putative intrinsically unstructured protein	cytoplasmic translation	molecular_function	polysome|cytoplasm
YBR280C	YBR280C	SAF1	hom	Verified	0.632366852096716	0.263573594445925	no	1244	0.265154725661071	909	NA	FT	PROTEOLYSIS		UBIQUITIN LIGASE COMPLEX	F-Box protein involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence; interacts with Skp1	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity	SCF ubiquitin ligase complex
YDR483W	YDR483W	KRE2	hom	Verified	0.631752882352044	0.263774183291894	no	1245	0.307041864422562	1017	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Alpha1,2-mannosyltransferase of the Golgi; involved in protein mannosylation; KRE2 has a paralog, KTR6, that arose from the whole genome duplication	N-glycan processing|cell wall mannoprotein biosynthetic process|protein O-linked glycosylation	alpha-1,2-mannosyltransferase activity	Golgi apparatus
YDR436W	YDR436W	PPZ2	hom	Verified	0.631483155579082	0.263862329800327	no	1246	0.258147598159548	891	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance	cellular sodium ion homeostasis	protein serine/threonine phosphatase activity	cellular_component
YLL026W	YLL026W	HSP104	hom	Verified	0.631256420137361	0.263936438389869	no	1247	0.267252670198247	915	NA	FT	PROTEIN LOCALIZATION|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Disaggregase; heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress	trehalose metabolism in response to heat stress|protein folding in endoplasmic reticulum|protein unfolding|chaperone cofactor-dependent protein refolding|inheritance of oxidatively modified proteins involved in replicative cell aging|cellular heat acclimation	ADP binding|unfolded protein binding|ATPase activity, coupled|chaperone binding|ATP binding	TRC complex|nucleus|cytoplasm
YMR158C-A_p	YMR158C-A	YMR158C-A	hom	Uncharacterized	0.629342286696348	0.264562496394087	no	1248	0.242062709501142	813	NA					Putative protein of unknown function, may contain a lipid attachment site; YMR158C-A is not an essential gene	biological_process	molecular_function	cellular_component
YMR069W	YMR069W	NAT4	hom	Verified	0.62861608441221	0.264800213812317	no	1249	0.286220654840815	984	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS		N alpha-acetyl-transferase, involved in acetylation of the N-terminal residues of histones H4 and H2A	histone acetylation	histone acetyltransferase activity	nucleus|cytoplasm
YDR511W	YDR511W	ACN9	hom	Verified	0.628155932436027	0.264950897640959	no	1250	0.225674371185066	762	NA	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM	MITOCHONDRION		Protein of the mitochondrial intermembrane space, required for acetate utilization and gluconeogenesis; has orthologs in higher eukaryotes	carbon utilization|regulation of gluconeogenesis	molecular_function	mitochondrion|mitochondrial intermembrane space
YDR411C	YDR411C	DFM1	hom	Verified	0.627346410170588	0.265216093849505	no	1251	0.242496013479291	815	NA	FT	SIGNALING|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	UBIQUITIN LIGASE COMPLEX	Endoplasmic reticulum (ER) localized protein involved in ER-associated protein degradation (ERAD), ER stress and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p	endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process	molecular_function	Doa10p ubiquitin ligase complex|integral to membrane|endoplasmic reticulum|Hrd1p ubiquitin ligase ERAD-L complex
YBR287W_p	YBR287W	YBR287W	hom	Uncharacterized	0.627091803008792	0.265299529975139	no	1252	0.238394576305513	784	NA	FT		ENDOPLASMIC RETICULUM		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene	biological_process	molecular_function	integral to membrane|endoplasmic reticulum
YFL053W	YFL053W	DAK2	hom	Verified	0.627036140619841	0.265317772611835	no	1253	0.251773580059428	871	NA	FT	CARBOHYDRATE METABOLISM			Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation	response to stress|glycerol catabolic process	glycerone kinase activity	cellular_component
YGR214W	YGR214W	RPS0A	hom	Verified	0.624524681683744	0.266141533133086	no	1254	0.265822247913729	898	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION		RIBOSOME	Ribosomal 40S subunit protein S0A; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2; RPS0A has a paralog, RPS0B, that arose from the whole genome duplication;	cytoplasmic translation|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA export from nucleus|ribosomal small subunit assembly|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit|90S preribosome
YJR117W	YJR117W	STE24	hom	Verified	0.624521239364424	0.26614266310465	no	1255	0.248149010937977	829	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION		Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans	CAAX-box protein processing|peptide pheromone maturation	metalloendopeptidase activity	mitochondrial outer membrane|integral to endoplasmic reticulum membrane|integral to membrane|nuclear inner membrane
YDL089W	YDL089W	NUR1	hom	Verified	0.623431016206578	0.266500660610246	no	1256	0.276571227902277	945	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS		Protein of unknown function; interacts with Csm1p, Lrs4p; required for rDNA repeat stability; null mutant causes increase in unequal sister-chromatid exchange; GFP-fusion protein localizes to the nuclear periphery, possible Cdc28p substrate	maintenance of rDNA	molecular_function	nuclear periphery
YGR054W	YGR054W	YGR054W	hom	Verified	0.621989883809611	0.266974259970074	no	1257	0.261098763393348	897	NA	FT	TRANSLATION			Eukaryotic initiation factor (eIF) 2A; associates specifically with both 40S subunits and 80 S ribosomes, and interacts genetically with both eIF5b and eIF4E; homologous to mammalian eIF2A	translational initiation	translation initiation factor activity	cytosolic ribosome|cytosolic small ribosomal subunit|ribosome
YDL131W	YDL131W	LYS21	hom	Verified	0.621442368134436	0.267154301416125	no	1258	0.23689679969036	834	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS|MITOCHONDRION		Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS21 has a paralog, LYS20, that arose from the whole genome duplication	lysine biosynthetic process via aminoadipic acid	homocitrate synthase activity	nucleus
YER167W	YER167W	BCK2	hom	Verified	0.621314042772258	0.267196507946616	no	1259	0.297703244764485	1021	NA	FT	CELL CYCLE	NUCLEUS		Protein rich in serine and threonine residues involved in protein kinase C signaling pathway, which controls cell integrity; overproduction suppresses pkc1 mutations	regulation of cell cycle|positive regulation of gene expression|G1/S transition of mitotic cell cycle	molecular_function	nucleus|cytoplasm
YKL050C	YKL050C	YKL050C	hom	Verified	0.620880688993445	0.267339063949983	no	1260	0.217379919169164	728	NA					Protein of unknown function; the YKL050W protein is a target of the SCFCdc4 ubiquitin ligase complex and YKL050W transcription is regulated by Azf1p	biological_process	molecular_function	cellular_component
YNR021W_p	YNR021W	YNR021W	hom	Uncharacterized	0.617480613915794	0.268458882141638	no	1261	0.257936200483188	860	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNR021W is not an essential gene	biological_process	molecular_function	endoplasmic reticulum
YBR108W	YBR108W	AIM3	hom	Verified	0.616552936211643	0.268764822741539	no	1262	0.26489553948578	901	NA	FT	CYTOSKELETON ORGANIZATION	CYTOSKELETON		Protein interacting with Rvs167p; null mutant is viable and displays elevated frequency of mitochondrial genome loss	actin cortical patch assembly	molecular_function	membrane raft|actin cortical patch
YGR067C_p	YGR067C	YGR067C	hom	Uncharacterized	0.616549653015927	0.268765905823851	no	1263	0.251989740294625	849	NA	FT		NUCLEUS		Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p	biological_process	sequence-specific DNA binding	cellular_component
YNL338W_d	YNL338W	YNL338W	hom	Dubious	0.614865399972239	0.269321807235473	no	1264	0.254598774885703	892	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps TEL14L-XC, which is Telomeric X element Core sequence on the left arm of Chromosome XIV	Unknown	Unknown	Unknown
YGL259W_p	YGL259W	YPS5	hom	Uncharacterized	0.614814851011412	0.269338500238726	no	1265	0.257651343890267	884	NA	FT	PROTEOLYSIS			Protein with similarity to GPI-anchored aspartic proteases such as Yap1p and Yap3p	biological_process	aspartic-type endopeptidase activity	cellular_component
YIL139C	YIL139C	REV7	hom	Verified	0.614791318196084	0.269346271759697	no	1266	0.253949518960502	865	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION|CHROMOSOME		Accessory subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair	error-prone translesion synthesis|error-free translesion synthesis	DNA-directed DNA polymerase activity	nuclear chromatin|mitochondrion|zeta DNA polymerase complex
YDL154W	YDL154W	MSH5	hom	Verified	0.614041899615568	0.269593819944092	no	1267	0.253082700486742	868	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Protein of the MutS family, forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis; msh5-Y823H mutation confers tolerance to DNA alkylating agents; homologs present in C. elegans and humans	reciprocal meiotic recombination	molecular_function	nucleus
YNR039C	YNR039C	ZRG17	hom	Verified	0.614011032833864	0.269604018312996	no	1268	0.242414952952788	825	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Msc2p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; zinc-regulated directly through Zap1p; transcription induced under conditions of zinc deficiency	zinc ion transport	zinc ion transmembrane transporter activity|metal ion transmembrane transporter activity	integral to membrane|endoplasmic reticulum
YAL013W	YAL013W	DEP1	hom	Verified	0.613985570022679	0.269612431358291	no	1269	0.276780622833886	958	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Transcriptional modulator involved in regulation of structural phospholipid biosynthesis genes and metabolically unrelated genes, as well as maintenance of telomeres, mating efficiency, and sporulation	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of chromatin silencing at rDNA|regulation of transcription from RNA polymerase II promoter|histone deacetylation|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of chromatin silencing at telomere|negative regulation of transcription from RNA polymerase II promoter|regulation of DNA-dependent DNA replication initiation|Unknown	molecular_function	Rpd3L-Expanded complex|Rpd3L complex
YHR129C	YHR129C	ARP1	hom	Verified	0.613509597195275	0.269769719462137	no	1270	0.261768457655129	906	NA	FT	CELL CYCLE|CYTOSKELETON ORGANIZATION	CYTOSKELETON		Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; putative ortholog of mammalian centractin	nuclear migration|establishment of mitotic spindle orientation	structural constituent of cytoskeleton	cell cortex|dynactin complex|spindle pole body|astral microtubule
YDL121C_p	YDL121C	YDL121C	hom	Uncharacterized	0.613455138549738	0.269787718580467	no	1271	0.252408715829097	841	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDL121C is not an essential protein	biological_process	molecular_function	endoplasmic reticulum
YDL214C	YDL214C	PRR2	hom	Verified	0.612207115974277	0.270200367050792	no	1272	0.265019884016163	898	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN PHOSPHORYLATION	NUCLEUS		Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor; mutant has increased aneuploidy tolerance	negative regulation of transcription from RNA polymerase II promoter by pheromones|negative regulation of conjugation with cellular fusion|protein phosphorylation	protein kinase activity|receptor signaling protein serine/threonine kinase activity	nucleus
YGR290W_d	YGR290W	YGR290W	hom	Dubious	0.612128263743707	0.27022644949437	no	1273	0.282994177885365	980	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; putative HLH protein; partially overlaps the verified ORF MAL11/YGR289C (a high-affinity maltose transporter)	Unknown	Unknown	Unknown
YLR319C	YLR319C	BUD6	hom	Verified	0.611955889677244	0.270283471122376	no	1274	0.28302801641543	943	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Actin- and formin-interacting protein; stimulates actin cable nucleation by recruiting actin monomers to Bni1p; involved in polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate	bipolar cellular bud site selection|positive regulation of formin-nucleated actin cable assembly|cellular bud site selection|Rho protein signal transduction|extrachromosomal circular DNA localization involved in cell aging|establishment of cell polarity|response to osmotic stress|cytokinesis	cytoskeletal regulatory protein binding	polarisome|actin cap|spindle pole body|mating projection tip
YPL203W	YPL203W	TPK2	hom	Verified	0.611905322483058	0.270300199975543	no	1275	0.267366481581308	932	NA	FT	SIGNALING|PROTEIN PHOSPHORYLATION	NUCLEUS		cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk3p; localizes to P-bodies during stationary phase	protein phosphorylation|Ras protein signal transduction|invasive growth in response to glucose limitation	cAMP-dependent protein kinase activity|protein kinase activity	nucleus|cAMP-dependent protein kinase complex
YER184C_p	YER184C	YER184C	hom	Uncharacterized	0.611886210923936	0.270306522677198	no	1276	0.280834902652717	987	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Putative zinc cluster protein; deletion confers sensitivity to Calcufluor white, and prevents growth on glycerol or lactate as sole carbon source	biological_process	sequence-specific DNA binding	cellular_component
YBL085W	YBL085W	BOI1	hom	Verified	0.610307182436522	0.270829169983936	no	1277	0.267309298799395	876	NA	FT	SIGNALING|CELL DIVISION	SITE OF POLARIZED GROWTH		Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication	cytokinesis, completion of separation|establishment of cell polarity|budding cell apical bud growth|Rho protein signal transduction	phospholipid binding	site of polarized growth|cellular bud|mating projection tip|cellular bud neck
YER185W	YER185W	PUG1	hom	Verified	0.60837755372638	0.27146854757789	no	1278	0.259617371673009	878	NA	FT		PLASMA MEMBRANE		Plasma membrane protein with roles in the uptake of protoprophyrin IX and the efflux of heme; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of proteins	heme transport	molecular_function	integral to membrane|plasma membrane
YOR155C	YOR155C	ISN1	hom	Verified	0.607259517039491	0.271839349944421	no	1279	0.270356713906473	908	NA	FT	NUCLEOTIDE METABOLISM			Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms	nicotinamide riboside biosynthetic process|inosine salvage|nicotinic acid riboside biosynthetic process	IMP 5'-nucleotidase activity	cellular_component
YOR377W	YOR377W	ATF1	hom	Verified	0.606072480126979	0.272233312199026	no	1280	0.247453304151683	837	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	ENDOMEMBRANE SYSTEM		Alcohol acetyltransferase; responsible for the major part of volatile acetate ester production during fermentation; main enzyme involved in terpenyl acetate synthesis; potential roles in lipid and sterol metabolism	Unknown|fermentation	alcohol O-acetyltransferase activity	lipid particle
YLR351C	YLR351C	NIT3	hom	Verified	0.605820199979753	0.272317077273396	no	1281	0.25571354288799	866	NA	FT		MITOCHONDRION		Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member	biological_process	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	mitochondrion|cytoplasm
YGL256W	YGL256W	ADH4	hom	Verified	0.602340452966068	0.273473769288225	no	1282	0.258689866615403	898	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Alcohol dehydrogenase isoenzyme type IV, dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency	fermentation|amino acid catabolic process to alcohol via Ehrlich pathway	alcohol dehydrogenase (NAD) activity	mitochondrion
YMR251W	YMR251W	GTO3	hom	Verified	0.601946982211579	0.273604714588121	no	1283	0.285446167060377	998	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Omega class glutathione transferase; putative cytosolic localization	glutathione metabolic process	glutathione transferase activity	cytoplasm
YHR154W	YHR154W	RTT107	hom	Verified	0.601638417763652	0.273707425151294	no	1284	0.299932354881378	1008	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Protein implicated in Mms22-dependent DNA repair during S phase; involved in recruiting the SMC5/6 complex to double-strand breaks; DNA damage induces phosphorylation by Mec1p at one or more SQ/TQ motifs; interacts with Mms22p and Slx4p; has four BRCT domains; has a role in regulation of Ty1 transposition; relative distribution to nuclear foci increases upon DNA replication stress	negative regulation of transposition, RNA-mediated|double-strand break repair	molecular_function	Cul8-RING ubiquitin ligase complex|nucleus
YDR402C	YDR402C	DIT2	hom	Verified	0.601462153803018	0.273766105960342	no	1285	0.289102527825745	994	NA	FT	CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS			N-formyltyrosine oxidase, sporulation-specific microsomal enzyme involved in the production of N,N-bisformyl dityrosine required for spore wall maturation, homologous to cytochrome P-450s	ascospore wall assembly	oxidoreductase activity	cellular_component
YDR371W_p	YDR371W	CTS2	hom	Uncharacterized	0.601261228937192	0.273833004327532	no	1286	0.261125378583918	873	NA	FT	CARBOHYDRATE METABOLISM			Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect	sporulation resulting in formation of a cellular spore	molecular_function	cytoplasm
YIL163C_p	YIL163C	YIL163C	hom	Uncharacterized	0.600546950041561	0.274070890451163	no	1287	0.263346860666557	892	NA					Protein of unknown function; mRNA identified as translated by ribosome profiling data	biological_process	molecular_function	cellular_component
YOL013C	YOL013C	HRD1	hom	Verified	0.598908404447557	0.274616983317507	no	1288	0.25493346949002	876	NA	FT	CELL WALL ORG/BIOGENESIS|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	UBIQUITIN LIGASE COMPLEX	Ubiquitin-protein ligase; required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; likely plays a general role in targeting proteins that persistently associate with and potentially obstruct the ER-localized translocon	fungal-type cell wall organization|ER-associated protein catabolic process	ubiquitin-protein ligase activity	Hrd1p ubiquitin ligase ERAD-M complex|integral to membrane|Hrd1p ubiquitin ligase ERAD-L complex|endoplasmic reticulum membrane
YER090W	YER090W	TRP2	hom	Verified	0.59883426957593	0.274641703599781	no	1289	0.442661908413702	1454	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM			Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p	tryptophan biosynthetic process	anthranilate synthase activity	anthranilate synthase complex|cytoplasm
YJR075W	YJR075W	HOC1	hom	Verified	0.59813749257768	0.274874097596584	no	1290	0.264049031557217	920	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	GOLGI APPARATUS		Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele	cell wall mannoprotein biosynthetic process|substituted mannan metabolic process	alpha-1,6-mannosyltransferase activity|transferase activity, transferring glycosyl groups	alpha-1,6-mannosyltransferase complex
YBR034C	YBR034C	HMT1	hom	Verified	0.597778497883103	0.274993869866774	no	1291	0.292745925718301	1000	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA LOCALIZATION	NUCLEUS		Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs, including Npl3p and Hrp1p, affecting their activity and nuclear export; methylates U1 snRNP protein Snp1p and ribosomal protein Rps2p; interacts genetically with genes encoding components of Rpd3(L) and this interaction is important for Rpd3 recruitment to the subtelomeric region.	mRNA export from nucleus|negative regulation of DNA-dependent transcription, termination|positive regulation of transcription elongation from RNA polymerase II promoter|peptidyl-arginine methylation	protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity	nucleus
YER014W	YER014W	HEM14	hom	Verified	0.597713748005782	0.275015475261922	no	1292	0.296967564598944	1000	NA	FT	OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM	MITOCHONDRION		Protoporphyrinogen oxidase, a mitochondrial enzyme that catalyzes the seventh step in the heme biosynthetic pathway, converting protoporphyrinogen IX to protoporphyrin IX; inhibited by diphenyl ether-type herbicides	heme biosynthetic process	oxygen-dependent protoporphyrinogen oxidase activity	mitochondrion|mitochondrial inner membrane
YJR003C_p	YJR003C	YJR003C	hom	Uncharacterized	0.595869138604204	0.275631325731401	no	1293	0.277266508027557	959	NA	FT		MITOCHONDRION		Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; predicted to be involved in ribosome biogenesis	biological_process	molecular_function	mitochondrion
YKR066C	YKR066C	CCP1	hom	Verified	0.59554470448587	0.275739712994839	no	1294	0.279975772474617	943	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress	cellular response to oxidative stress	cytochrome-c peroxidase activity	mitochondrion|mitochondrial intermembrane space
YIL111W	YIL111W	COX5B	hom	Verified	0.594229948599188	0.276179162247548	no	1295	0.261007694010957	907	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Subunit Vb of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Bp is predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth; COX5B has a paralog, COX5A, that arose from the whole genome duplication	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity|nitrite reductase (NO-forming) activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YDL123W	YDL123W	SNA4	hom	Verified	0.593519257366548	0.276416849559531	no	1296	0.29394335370583	1016	NA					Protein of unknown function, localized to the vacuolar outer membrane; predicted to be palmitoylated	biological_process	molecular_function	fungal-type vacuole lumen|fungal-type vacuole membrane
YDR068W	YDR068W	DOS2	hom	Verified	0.59256837267153	0.276735025266639	no	1297	0.250873032604392	867	NA					Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YOR339C	YOR339C	UBC11	hom	Verified	0.592504393440199	0.276756439810359	no	1298	0.266229685414665	892	NA					Ubiquitin-conjugating enzyme most similar in sequence to Xenopus ubiquitin-conjugating enzyme E2-C, but not a true functional homolog of this E2; unlike E2-C, not required for the degradation of mitotic cyclin Clb2	protein polyubiquitination|protein monoubiquitination	ubiquitin-protein ligase activity	cytoplasm
YOR198C	YOR198C	BFR1	hom	Verified	0.592391271643114	0.276794304891212	no	1299	0.311325121574575	1058	NA	FT	CELL CYCLE	ENDOMEMBRANE SYSTEM		Component of mRNP complexes associated with polyribosomes; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity	meiosis|mRNA metabolic process|regulation of mitosis	RNA binding	ribonucleoprotein complex|polysome|nuclear outer membrane-endoplasmic reticulum membrane network
YLR003C	YLR003C	CMS1	hom	Verified	0.591995614808292	0.276926762436649	no	1300	0.250390877374512	861	NA	FT		NUCLEUS		Putative subunit of the 90S preribosome processome complex; overexpression rescues supressor mutant of mcm10; null mutant is viable; relocalizes from nucleus to cytoplasm upon DNA replication stress	biological_process	molecular_function	nucleus|90S preribosome
YHR071W	YHR071W	PCL5	hom	Verified	0.591861771684107	0.276971577309897	no	1301	0.239229647507042	856	NA	FT	CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Cyclin, interacts with and phosphorylated by Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity	negative regulation of sequence-specific DNA binding transcription factor activity|regulation of protein stability|negative regulation of macroautophagy	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex|nucleus
YGR166W	YGR166W	TRS65	hom	Verified	0.591330353312465	0.277149547864574	no	1302	0.313753163561838	1031	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|CELL WALL ORG/BIOGENESIS	GOLGI APPARATUS		Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p; involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi; role in cell wall beta-glucan biosynthesis and the stress response	intra-Golgi vesicle-mediated transport|protein complex assembly	Rab guanyl-nucleotide exchange factor activity	TRAPP complex|trans-Golgi network
YBL081W_p	YBL081W	YBL081W	hom	Uncharacterized	0.591309430793818	0.277156555903342	no	1303	0.257171949201989	877	NA					Non-essential protein of unknown function; null mutation results in a decrease in plasma membrane electron transport	biological_process	molecular_function	cellular_component
YDR200C	YDR200C	VPS64	hom	Verified	0.591211648278912	0.277189309498458	no	1304	0.326946511391731	1105	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|SIGNALING|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein required for cytoplasm to vacuole targeting of proteins; forms a complex with Far3p and Far7p to Far11p involved in recovery from pheromone-induced cell cycle arrest; mutant has increased aneuploidy tolerance	re-entry into mitotic cell cycle after pheromone arrest|protein targeting to vacuole	molecular_function	endoplasmic reticulum membrane|cytoplasm
YAR047C_d	YAR047C	YAR047C	hom	Dubious	0.59110109983914	0.277226341495766	no	1305	0.266769317759444	916	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YER181C_d	YER181C	YER181C	hom	Dubious	0.59084912594355	0.277310757851088	no	1306	0.270064901114703	930	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative data; extensively overlaps a Ty1 LTR; protein product is detected in highly purified mitochondria in high-throughput studies	Unknown	Unknown	Unknown
YLR255C_d	YLR255C	YLR255C	hom	Dubious	0.590280331245435	0.277501361791734	no	1307	0.29226217467025	996	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOL118C_d	YOL118C	YOL118C	hom	Dubious	0.589287983168028	0.277834052313641	no	1308	0.296580677637639	989	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOL090W	YOL090W	MSH2	hom	Verified	0.588347624823979	0.278149492556435	no	1309	0.28741034963578	991	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS|CHROMOSOME		Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity and involved in interstrand cross-link repair; Msh2p-Msh6p binds to and hydrolyzes ATP	mismatch repair|mitotic recombination|meiotic gene conversion|meiotic mismatch repair|removal of nonhomologous ends|DNA recombination|chromatin silencing at silent mating-type cassette	loop DNA binding|single base insertion or deletion binding|ATP binding|Y-form DNA binding|double-strand/single-strand DNA junction binding|DNA insertion or deletion binding|guanine/thymine mispair binding|four-way junction DNA binding|ATPase activity	MutSbeta complex|nuclear chromosome|MutSalpha complex|nucleus
YHR032W	YHR032W	ERC1	hom	Verified	0.588009369063456	0.278263002085375	no	1310	0.27169790254388	930	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM			Member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily; overproduction confers ethionine resistance and accumulation of S-adenosylmethionine	S-adenosylmethionine biosynthetic process|transmembrane transport	antiporter activity	integral to membrane
YPR121W	YPR121W	THI22	hom	Verified	0.587770924385057	0.27834303127032	no	1311	0.247095454912484	843	NA					Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis	thiamine biosynthetic process	phosphomethylpyrimidine kinase activity|hydroxymethylpyrimidine kinase activity	cellular_component
YHR003C	YHR003C	YHR003C	hom	Verified	0.585329141624193	0.279163211841216	no	1312	0.238409400111405	811	NA	FT		MITOCHONDRION		Protein of unknown function, localized to the mitochondrial outer membrane	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion
YPL134C	YPL134C	ODC1	hom	Verified	0.585275602506253	0.279181208472626	no	1313	0.270161414385747	937	NA	FT		MITOCHONDRION		Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation	mitochondrial transport	dicarboxylic acid transmembrane transporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YDR003W	YDR003W	RCR2	hom	Verified	0.584441496830189	0.279461657444624	no	1314	0.263276894934623	903	NA	FT	VESICLE-MEDIATED TRANSPORT			Vacuolar protein; presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR2 has a paralog, RCR1, that arose from the whole genome duplication	vesicle-mediated transport	molecular_function	vesicle|integral to membrane|fungal-type vacuole|cytoplasm
YOR350C	YOR350C	MNE1	hom	Verified	0.583631175914137	0.279734240290518	no	1315	0.283769454153958	974	NA	FT	RNA PROCESSING	MITOCHONDRION		Mitochondrial matrix protein involved in splicing Group I aI5-beta intron from COX1 mRNA	Group I intron splicing	molecular_function	mitochondrion|ribonucleoprotein complex|mitochondrial matrix
YFL063W_d	YFL063W	YFL063W	hom	Dubious	0.583215220108819	0.27987421323713	no	1316	0.237862720913852	822	NA					Dubious open reading frame, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKR003W	YKR003W	OSH6	hom	Verified	0.581519528367104	0.280445180315615	no	1317	0.25621027385333	916	NA	FT	VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION	ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Member of an oxysterol-binding protein family; overlapping, redundant functions in sterol metabolism and which collectively perform a function essential for viability; GFP-fusion protein localizes to the cell periphery; overexpression extends lifespan by promoting vacuolar fusion	sterol homeostasis|maintenance of cell polarity|endocytosis|sterol transport|exocytosis|sterol metabolic process	phosphatidic acid binding|lipid binding|phosphatidylinositol-3,4-bisphosphate binding|oxysterol binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-5-phosphate binding|phosphatidylinositol-4-phosphate binding	cortical endoplasmic reticulum|extrinsic to membrane|cytoplasm
YDR135C	YDR135C	YCF1	hom	Verified	0.581307365009607	0.280516658850965	no	1318	0.256497864728788	885	NA	FT	NUCLEOTIDE METABOLISM			Vacuolar glutathione S-conjugate transporter; member of the ATP-binding cassette family; has a role in detoxifying metals such as cadmium, mercury, and arsenite; also transports unconjugated bilirubin, selenodigluthatione, and oxidized glutathione; similar to human cystic fibrosis protein CFTR	bilirubin transport|response to metal ion|transmembrane transport	bilirubin transmembrane transporter activity|glutathione S-conjugate-exporting ATPase activity	fungal-type vacuole membrane|integral to membrane
YKL202W_d	YKL202W	YKL202W	hom	Dubious	0.580978751605534	0.280627387193042	no	1319	0.246470343031262	858	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YEL028W_d	YEL028W	YEL028W	hom	Dubious	0.580555665937712	0.280769979686979	no	1320	0.29930288666841	1042	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKL116C	YKL116C	PRR1	hom	Verified	0.580525411855929	0.280780177557423	no	1321	0.236822708803715	809	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN PHOSPHORYLATION			Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor	negative regulation of transcription from RNA polymerase II promoter by pheromones|negative regulation of conjugation with cellular fusion|protein phosphorylation	protein kinase activity|receptor signaling protein serine/threonine kinase activity	cytoplasm
YBR067C	YBR067C	TIP1	hom	Verified	0.579484789304448	0.28113105356235	no	1322	0.28142005982758	960	NA	FT	CELL WALL ORG/BIOGENESIS			Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins	fungal-type cell wall organization	structural constituent of cell wall|lipase activity	fungal-type cell wall
YKL149C	YKL149C	DBR1	hom	Verified	0.578235035712695	0.281552723853739	no	1323	0.266224602742928	926	NA	FT	RNA PROCESSING	NUCLEUS		RNA lariat debranching enzyme, involved in intron turnover; required for efficient Ty1 transposition	snoRNA metabolic process|pseudohyphal growth|RNA catabolic process|transposition, RNA-mediated	RNA lariat debranching enzyme activity	nucleus
YKL166C	YKL166C	TPK3	hom	Verified	0.577908931723338	0.281662802400333	no	1324	0.256517794191357	884	NA	FT	SIGNALING|MITOCHONDRION ORGANIZATION|PROTEIN PHOSPHORYLATION	NUCLEUS		cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication	protein phosphorylation|mitochondrion organization|Ras protein signal transduction	cAMP-dependent protein kinase activity|protein kinase activity	cAMP-dependent protein kinase complex|nucleus|cytoplasm
YDL233W_p	YDL233W	MFG1	hom	Uncharacterized	0.577736615231292	0.281720977344136	no	1325	0.273458470714132	924	NA	FT		NUCLEUS		Regulator of filamentous growth; interacts with FLO11 promoter and regulates FLO11 expression; binds to transcription factors Flo8p and Mss11p; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YDL233W is not an essential gene	biological_process	molecular_function	nucleus|cytoplasm
YGL080W	YGL080W	FMP37	hom	Verified	0.577318913987898	0.281862019489749	no	1326	0.27828524632438	953	NA	FT		MITOCHONDRION		Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; null mutant displays slow growth that is complemented by expression of human or mouse ortholog; mutation in human ortholog is associated with lactic acidosis and hyperpyruvatemia	mitochondrial pyruvate transport	pyruvate transmembrane transporter activity	mitochondrion|integral to mitochondrial inner membrane
YPL149W	YPL149W	ATG5	hom	Verified	0.577000948309045	0.281969407454929	no	1327	0.265001820167239	903	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Conserved protein involved in autophagy and the Cvt pathway; undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation; conjugated Atg12p also forms a complex with Atg16p that is essential for autophagosome formation	C-terminal protein lipidation|mitochondrion degradation|piecemeal microautophagy of nucleus|macroautophagy|CVT pathway	Atg8 ligase activity	cytosol|Atg12-Atg5-Atg16 complex|pre-autophagosomal structure|autophagic vacuole
YAL053W	YAL053W	FLC2	hom	Verified	0.576546490453625	0.282122927735815	no	1328	0.301351919168521	1022	NA	FT	CELL WALL ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication	protein folding|fungal-type cell wall biogenesis|FAD transport|transmembrane transport	FAD transmembrane transporter activity	integral to membrane|endoplasmic reticulum|cytoplasm
YDR017C	YDR017C	KCS1	hom	Verified	0.575219855366557	0.282571308014619	no	1329	0.25453036587208	870	NA					Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response and telomere maintenance	inositol phosphate biosynthetic process	inositol heptakisphosphate kinase activity|inositol hexakisphosphate kinase activity|inositol-1,3,4,5,6-pentakisphosphate kinase activity|inositol heptakisphosphate 5-kinase activity	cytoplasm
YKR065C	YKR065C	PAM17	hom	Verified	0.573656302800989	0.283100201807433	no	1330	0.264366446842886	897	NA	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Constituent of the TIM23 complex; proposed alternatively to be a component of the import motor (PAM complex) or to interact with and modulate the core TIM23 (Translocase of the Inner mitochondrial Membrane) complex; protein abundance increases in response to DNA replication stress	protein import into mitochondrial matrix	molecular_function	mitochondrion|presequence translocase-associated import motor
YBR205W	YBR205W	KTR3	hom	Verified	0.573427750413455	0.283177552666899	no	1331	0.245264862872404	818	NA	FT	CARBOHYDRATE METABOLISM			Putative alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; Svp26p mediates uptake of Ktr3p into COPII vesicles; relocalizes from nucleus to vacuole upon DNA replication stress	N-glycan processing|protein O-linked glycosylation	mannosyltransferase activity	fungal-type vacuole
YOR286W	YOR286W	RDL2	hom	Verified	0.572986112896009	0.283327048394938	no	1332	0.27435252302242	902	NA	FT		MITOCHONDRION		Protein with rhodanese activity; contains a rhodanese-like domain similar to Rdl1p, Uba4p, Tum1p, and Ych1p; overexpression causes a cell cycle delay; null mutant displays elevated frequency of mitochondrial genome loss	biological_process	thiosulfate sulfurtransferase activity	mitochondrion
YDL023C_d	YDL023C	YDL023C	hom	Dubious	0.572756986169432	0.283404623440747	no	1333	0.294811450583141	1006	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance	Unknown	Unknown	Unknown
YHR160C	YHR160C	PEX18	hom	Verified	0.572451785069443	0.283507970670013	no	1334	0.29423361631984	994	NA	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION			Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex21p	protein import into peroxisome matrix	protein binding	cytosol|peroxisome
YDL001W	YDL001W	RMD1	hom	Verified	0.571958559293841	0.283675025003936	no	1335	0.276518568507686	969	NA	FT	CELL CYCLE			Cytoplasmic protein required for sporulation	biological_process	molecular_function	cytoplasm
YDR143C	YDR143C	SAN1	hom	Verified	0.571681603867439	0.28376884977824	no	1336	0.286428034345507	959	NA	FT	PROTEOLYSIS	NUCLEUS		Ubiquitin-protein ligase; involved in the proteasome-dependent degradation of aberrant nuclear proteins; targets substrates with regions of exposed hydrophobicity containing 5 or more contiguous hydrophobic residues; contains intrinsically disordered regions that contribute to substrate recognition	nucleus-associated proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to misfolded protein|response to stress	ubiquitin-protein ligase activity	nucleus|cytoplasm
YGL185C_p	YGL185C	YGL185C	hom	Uncharacterized	0.571469433790484	0.283840737133348	no	1337	0.323225081638678	1097	NA	FT	OXIDATION-REDUCTION PROCESS			Putative protein with sequence similarity to hydroxyacid dehydrogenases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	metabolic process	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	cytoplasm
YDL127W	YDL127W	PCL2	hom	Verified	0.570314389070846	0.284232241622756	no	1338	0.234926246998005	822	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	NUCLEUS|SITE OF POLARIZED GROWTH		Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; localizes to sites of polarized cell growth	G1 phase of mitotic cell cycle|regulation of establishment or maintenance of cell polarity|regulation of cyclin-dependent protein kinase activity|septin ring organization	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex|incipient cellular bud site|nucleus|cellular bud neck|cellular bud tip
YLR263W	YLR263W	RED1	hom	Verified	0.569189426107117	0.284613797842954	no	1339	0.257713734705951	852	NA	FT	CELL CYCLE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Protein component of the synaptonemal complex axial elements, involved in chromosome segregation during the first meiotic division; critical for coupling checkpoint signaling to SC formation; interacts with Hop1p, Mec3p and Ddc1p	synaptonemal complex assembly|meiotic recombination checkpoint|positive regulation of catalytic activity	chromatin DNA binding|structural molecule activity	lateral element
YMR099C	YMR099C	YMR099C	hom	Verified	0.569158235278438	0.28462438039002	no	1340	0.301734769066577	1047	NA	FT	CARBOHYDRATE METABOLISM	NUCLEUS		Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS	cellular carbohydrate metabolic process	glucose-6-phosphate 1-epimerase activity	nucleus|cytoplasm
YGL117W_p	YGL117W	YGL117W	hom	Uncharacterized	0.569000872444641	0.284677773936119	no	1341	0.332940025958005	1119	NA	FF				Putative protein of unknown function	biological_process	molecular_function	cellular_component
YNL023C	YNL023C	FAP1	hom	Verified	0.56806038161943	0.284996984129234	no	1342	0.262584993163016	916	NA	FT		NUCLEUS		Protein that binds to Fpr1p, conferring rapamycin resistance by competing with rapamycin for Fpr1p binding; accumulates in the nucleus upon treatment of cells with rapamycin; has similarity to D. melanogaster shuttle craft and human NFX1	biological_process	sequence-specific DNA binding transcription factor activity	cytoplasm
YKL124W	YKL124W	SSH4	hom	Verified	0.566435450366853	0.285548900802603	no	1343	0.238914347043243	840	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT			Specificity factor required for Rsp5p-dependent ubiquitination and sorting of cargo proteins at the multivesicular body; identified as a high-copy suppressor of a SHR3 deletion, increasing steady-state levels of amino acid permeases	protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|vesicle-mediated transport	molecular_function	fungal-type vacuole
YIL089W	YIL089W	YIL089W	hom	Verified	0.565633569678512	0.285821451255297	no	1344	0.257796237730965	859	NA	FT		ENDOPLASMIC RETICULUM		Protein of unknown function found in the ER and vacuole lumen; overexpression of YIL089W affects endocytic protein trafficking	biological_process	molecular_function	fungal-type vacuole lumen|integral to membrane|endoplasmic reticulum
YBR297W	YBR297W	MAL33	hom	Verified	0.565322755474936	0.285927126853306	no	1345	0.286928926893295	989	NA	FT	TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM	NUCLEUS		MAL-activator protein, part of complex locus MAL3; nonfunctional in genomic reference strain S288C	cellular carbohydrate metabolic process|regulation of transcription, DNA-dependent	sequence-specific DNA binding transcription factor activity	nucleus
YBR022W	YBR022W	POA1	hom	Verified	0.564654879967558	0.286154264694253	no	1346	0.271065687045136	966	NA	FT	RNA PROCESSING			Phosphatase that is highly specific for ADP-ribose 1''-phosphate, a tRNA splicing metabolite; may have a role in regulation of tRNA splicing	tRNA splicing, via endonucleolytic cleavage and ligation	phosphatase activity	cellular_component
YKR049C	YKR049C	FMP46	hom	Verified	0.564649117336868	0.286156224880739	no	1347	0.268088613621629	910	NA	FT	OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Putative redox protein containing a thioredoxin fold; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	oxidoreductase activity	mitochondrion
YGR291C_d	YGR291C	YGR291C	hom	Dubious	0.564366708262885	0.286252295497229	no	1348	0.295025606190984	976	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGR196C	YGR196C	FYV8	hom	Verified	0.563502268940778	0.286546457753176	no	1349	0.287237022228264	955	NA					Protein of unknown function, required for survival upon exposure to K1 killer toxin	biological_process	molecular_function	cytoplasm
YPL196W	YPL196W	OXR1	hom	Verified	0.561496084172224	0.287229699511707	no	1350	0.275539283209081	978	NA	FT	RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		Protein of unknown function required for normal levels of resistance to oxidative damage, null mutants are sensitive to hydrogen peroxide; member of a conserved family of proteins found in eukaryotes	cellular response to oxidative stress	molecular_function	mitochondrion
YJL042W	YJL042W	MHP1	hom	Verified	0.561291068408918	0.287299564662173	no	1351	0.273381427244152	917	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	CYTOSKELETON		Microtubule-associated protein involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; similar to Drosophila protein MAP and to mammalian MAP4 proteins	fungal-type cell wall organization|negative regulation of microtubule depolymerization	structural constituent of cytoskeleton	microtubule
YOR127W	YOR127W	RGA1	hom	Verified	0.561090131644927	0.287368047575414	no	1352	0.29644775992983	1000	NA	FT	SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		GTPase-activating protein for polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; relocalizes from bud neck to cytoplasm upon DNA replication stress	budding cell isotropic bud growth|pheromone-dependent signal transduction involved in conjugation with cellular fusion|pseudohyphal growth|actin filament organization|establishment of cell polarity|small GTPase mediated signal transduction|invasive growth in response to glucose limitation|budding cell apical bud growth	Rho GTPase activator activity	cellular bud neck split septin rings
YDR257C	YDR257C	RKM4	hom	Verified	0.559322585327651	0.287970792078817	no	1353	0.263347763850347	893	NA	FT		NUCLEUS		Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 55); nuclear SET-domain containing protein	peptidyl-lysine monomethylation	protein-lysine N-methyltransferase activity	nucleus
YMR265C_p	YMR265C	YMR265C	hom	Uncharacterized	0.557310963672894	0.288657493104717	no	1354	0.284565218772508	985	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YBL049W	YBL049W	MOH1	hom	Verified	0.556572886264767	0.288909641555734	no	1355	0.310701003940803	1067	NA					Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for survival in stationary phase	biological_process	molecular_function	cellular_component
YBL055C	YBL055C	YBL055C	hom	Verified	0.556361206960516	0.288981976410052	no	1356	0.27121463470001	899	NA	FT	RESPONSE TO OXIDATIVE STRESS			3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases	cellular response to oxidative stress|apoptotic DNA fragmentation	3'-5'-exodeoxyribonuclease activity|endonuclease activity	cytoplasm
YKR054C	YKR054C	DYN1	hom	Verified	0.55563770797861	0.28922927411456	no	1357	0.255529507254245	864	NA	FT	CELL CYCLE|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	CYTOSKELETON		Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p	nuclear migration along microtubule|establishment of mitotic spindle orientation|mitotic spindle elongation|mitotic sister chromatid segregation	microtubule motor activity	cytoplasmic dynein complex|cell cortex|cytoplasmic microtubule|spindle pole body|astral microtubule
YPR027C_p	YPR027C	YPR027C	hom	Uncharacterized	0.554784748811176	0.28952095004793	no	1358	0.303121317222716	1072	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YML058W	YML058W	SML1	hom	Verified	0.553676679249066	0.289900069084409	no	1359	0.238491069852419	815	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION	NUCLEUS		Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase	mitochondrion organization|response to DNA damage stimulus	enzyme inhibitor activity	nucleus|cytoplasm
YLR190W	YLR190W	MMR1	hom	Verified	0.552999115669141	0.290132007858579	no	1360	0.257545540315106	863	NA	FT	CELL CYCLE|CELL DIVISION|MITOCHONDRION ORGANIZATION	MITOCHONDRION|SITE OF POLARIZED GROWTH		Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p	mitochondrion inheritance	molecular_function	mitochondrial outer membrane|incipient cellular bud site|mitochondrion|cellular bud|cellular bud neck
YKL132C	YKL132C	RMA1	hom	Verified	0.552668276477637	0.290245289978858	no	1361	0.269267357095188	912	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Putative dihydrofolate synthetase; has similarity to Fol3p and to E. coli folylpolyglutamate synthetase/dihydrofolate synthetase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	tetrahydrofolylpolyglutamate synthase activity	mitochondrion
YDL146W	YDL146W	LDB17	hom	Verified	0.551389692334391	0.290683282583663	no	1362	0.272301129803507	939	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein involved in the regulation of endocytosis; transiently recruited to actin cortical patches in a SLA1-dependent manner after late coat component assembly; GFP-fusion protein localizes to the periphery, cytoplasm, bud, and bud neck	endocytosis	molecular_function	cellular bud|cellular bud neck|cytoplasm|actin cortical patch
YER183C	YER183C	FAU1	hom	Verified	0.551067438413423	0.290793722850962	no	1363	0.296820149478544	1032	NA	FT	COFACTOR METABOLISM	MITOCHONDRION		5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis	folic acid-containing compound biosynthetic process	5-formyltetrahydrofolate cyclo-ligase activity	mitochondrion
YKL129C	YKL129C	MYO3	hom	Verified	0.549898647033306	0.291194446134208	no	1364	0.250972281983571	834	NA	FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION	CYTOSKELETON		One of two type I myosins; localizes to actin cortical patches; deletion of MYO3 has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization	bipolar cellular bud site selection|fungal-type cell wall organization|endocytosis|exocytosis|actin cortical patch localization|response to osmotic stress	microfilament motor activity	actin cortical patch
YML083C	YML083C	YML083C	hom	Verified	0.549643924961573	0.291281812490356	no	1365	0.272069132369963	939	NA					Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions	biological_process	molecular_function	cellular_component
YDR033W	YDR033W	MRH1	hom	Verified	0.545661744067961	0.29264923668889	no	1366	0.292959857595933	995	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION|PLASMA MEMBRANE		Protein that localizes primarily to the plasma membrane; also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; MRH1 has a paralog, YRO2, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrion|integral to membrane|plasma membrane
YER182W_p	YER182W	FMP10	hom	Uncharacterized	0.545652804401566	0.292652309794989	no	1367	0.289128901555334	990	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YOL001W	YOL001W	PHO80	hom	Verified	0.545515143702133	0.292699634027885	no	1368	0.31892435428573	1097	NA	FF|FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CELL CYCLE|SIGNALING|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Cyclin, interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling	negative regulation of phosphate metabolic process|regulation of cyclin-dependent protein kinase activity|negative regulation of calcium-mediated signaling|negative regulation of transcription from RNA polymerase II promoter|cellular metal ion homeostasis|regulation of protein localization|negative regulation of macroautophagy	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex|nucleus
YNL276C_d	YNL276C	YNL276C	hom	Dubious	0.544604888800341	0.293012645832426	no	1369	0.297081396340363	1028	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene MET2/YNL277W	Unknown	Unknown	Unknown
YJR014W	YJR014W	TMA22	hom	Verified	0.544530227779763	0.293038326608439	no	1370	0.237484572888108	788	NA	FT	TRANSLATION		RIBOSOME	Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1; protein abundance increases in response to DNA replication stress	biological_process	RNA binding	ribosome|cytoplasm
YKL096W-A	YKL096W-A	CWP2	hom	Verified	0.544315100731888	0.293112328615902	no	1371	0.294475954597364	1018	NA	FT	ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS			Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored	fungal-type cell wall organization|regulation of pH	structural constituent of cell wall	fungal-type cell wall
YKL135C	YKL135C	APL2	hom	Verified	0.544106250843731	0.293184179620271	no	1372	0.323301978431426	1096	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS|PLASMA MEMBRANE		Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress	Golgi to vacuole transport|vesicle-mediated transport	clathrin binding	AP-1 adaptor complex
YER151C	YER151C	UBP3	hom	Verified	0.543971242160924	0.293230631246775	no	1373	0.317167203932625	1067	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS			Ubiquitin-specific protease involved in transport and osmotic response; interacts with Bre5p to co-regulate anterograde and retrograde transport between the ER and Golgi; involved in transcription elongation in response to osmostress through phosphorylation at Ser695 by Hog1p; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin; also has mRNA binding activity; protein abundance increases in response to DNA replication stress	protein deubiquitination|ribophagy|regulation of ER to Golgi vesicle-mediated transport|regulation of response to osmotic stress	ubiquitin-specific protease activity|mRNA binding	cytoplasm
YNL176C_p	YNL176C	TDA7	hom	Uncharacterized	0.543091207383396	0.293533503095492	no	1374	0.29492327708708	986	NA					Cell cycle-regulated gene of unknown function, promoter bound by Fkh2p; null mutant is sensitive to expression of the top1-T722A allele	biological_process	molecular_function	fungal-type vacuole
YAL027W	YAL027W	SAW1	hom	Verified	0.542945551995896	0.293583645671008	no	1375	0.249202264147631	837	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		5'- and 3'-flap DNA binding protein; stimulates the endonuclease activity of Rad1/Rad10p; involved in Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during double-strand break repair via single-strand annealing; green fluorescent protein (GFP)-fusion protein localizes to the nucleus	double-strand break repair via single-strand annealing, removal of nonhomologous ends	molecular_function	nucleus
YLR273C	YLR273C	PIG1	hom	Verified	0.541851371159357	0.2939604494809	no	1376	0.260205734825708	891	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Putative targeting subunit for the type-1 protein phosphatase Glc7p that tethers it to the Gsy2p glycogen synthase	regulation of glycogen biosynthetic process	protein phosphatase type 1 regulator activity	protein phosphatase type 1 complex
YPL156C	YPL156C	PRM4	hom	Verified	0.541225342832378	0.294176135811702	no	1377	0.27251127460653	952	NA					Pheromone-regulated protein proposed to be involved in mating; predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift	biological_process	molecular_function	integral to membrane
YHL024W	YHL024W	RIM4	hom	Verified	0.541006416905355	0.29425157989079	no	1378	0.312838128632787	1082	NA	FT	CELL CYCLE			Putative RNA-binding protein required for the expression of early and middle sporulation genes	meiosis|reciprocal meiotic recombination|sporulation resulting in formation of a cellular spore|premeiotic DNA replication	RNA binding	cytoplasm
YNL194C	YNL194C	YNL194C	hom	Verified	0.540659232028533	0.294371241617205	no	1379	0.284647149628299	967	NA	FT		ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Integral membrane protein required for sporulation and plasma membrane sphingolipid content; has sequence similarity to SUR7 and FMP45; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; GFP-fusion protein is more abundant at MCCs (membrane compartment occupied by Can1) in the presence of glycerol and oleate	ascospore formation	molecular_function	cell cortex|integral to membrane|endoplasmic reticulum|plasma membrane|cytoplasm
YIR024C	YIR024C	YIR024C	hom	Verified	0.540426447131218	0.294451486502406	no	1380	0.306687167880291	1041	NA	FT		MITOCHONDRION		Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; interacts with Arh1p, a mitochondrial oxidoreductase; deletion mutant has a respiratory growth defect	biological_process	molecular_function	mitochondrion
YPL074W	YPL074W	YTA6	hom	Verified	0.540150169451762	0.294546737185107	no	1381	0.247591678778065	865	NA					Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family; localized to the cortex of mother cells but not to daughter cells; relocalizes from cytoplasm to plasma membrane foci upon DNA replication stress	biological_process	ATPase activity	cell cortex
YPL101W	YPL101W	ELP4	hom	Verified	0.539990759104312	0.294601702650831	no	1382	0.321210968939441	1101	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity	regulation of transcription from RNA polymerase II promoter|tRNA wobble uridine modification	ATPase activity|tRNA binding	Elongator holoenzyme complex|cytoplasm
YER087C-B	YER087C-B	SBH1	hom	Verified	0.539686878085703	0.294706495415248	no	1383	0.329205856388441	1146	NA	FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Beta subunit of the Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p); involved in protein translocation into the endoplasmic reticulum; interacts with the exocyst complex and also with Rtn1p; homologous to Sbh2p	posttranslational protein targeting to membrane, translocation|SRP-dependent cotranslational protein targeting to membrane, translocation	ARF guanyl-nucleotide exchange factor activity|P-P-bond-hydrolysis-driven protein transmembrane transporter activity	Sec61 translocon complex
YDL168W	YDL168W	SFA1	hom	Verified	0.539482637229648	0.294776937126321	no	1384	0.329089307232767	1089	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Bifunctional alcohol dehydrogenase and formaldehyde dehydrogenase; formaldehyde dehydrogenase activity is glutathione-dependent; functions in formaldehyde detoxification and formation of long chain and complex alcohols, regulated by Hog1p-Sko1p; protein abundance increases in response to DNA replication stress	furaldehyde metabolic process|formaldehyde catabolic process|amino acid catabolic process to alcohol via Ehrlich pathway	S-(hydroxymethyl)glutathione dehydrogenase activity|hydroxymethylfurfural reductase (NADH) activity|alcohol dehydrogenase (NAD) activity	mitochondrion|cytoplasm
YER096W	YER096W	SHC1	hom	Verified	0.539153810587983	0.294890364196527	no	1385	0.30361931652369	1029	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Sporulation-specific activator of Chs3p (chitin synthase III); required for the synthesis of the chitosan layer of ascospores; transcriptionally induced at alkaline pH; SHC1 has a paralog, SKT5, that arose from the whole genome duplication	ascospore formation|chitin biosynthetic process	enzyme activator activity	prospore membrane
YGL078C	YGL078C	DBP3	hom	Verified	0.538637847624121	0.295068383517475	no	1386	0.302412123387907	1058	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		RNA-Dependent ATPase, member of DExD/H-box family; involved in cleavage of site A3 within the ITS1 spacer during rRNA processing; not essential for growth, but deletion causes severe slow-growth phenotype	endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	RNA-dependent ATPase activity	nucleolus|preribosome, large subunit precursor
YOL048C	YOL048C	RRT8	hom	Verified	0.538208559410377	0.295216535730044	no	1387	0.288647026601056	956	NA					Protein of unknown function; identified in a screen for mutants with increased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to lipid particles; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	integral to membrane|lipid particle
YGR015C_p	YGR015C	YGR015C	hom	Uncharacterized	0.538170999895918	0.295229499571744	no	1388	0.309587130693312	1031	NA	FT		MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion	biological_process	molecular_function	mitochondrion
YER084W_p	YER084W	YER084W	hom	Uncharacterized	0.537898869319632	0.295323434536653	no	1389	0.301793798753723	1033	NA					Protein of unknown function; expressed at both mRNA and protein levels	biological_process	molecular_function	cellular_component
YDL231C	YDL231C	BRE4	hom	Verified	0.537225893332799	0.295555793735378	no	1390	0.301775006083468	1008	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION			Zinc finger protein containing five transmembrane domains; null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect intracellular transport	endocytosis	molecular_function	integral to membrane
YPL172C	YPL172C	COX10	hom	Verified	0.537112628843339	0.295594908959593	no	1391	0.322332910364046	1104	NA	FT	COFACTOR METABOLISM	MITOCHONDRION		Heme A:farnesyltransferase, catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; human ortholog is associated with mitochondrial disorders	heme a biosynthetic process	protoheme IX farnesyltransferase activity	mitochondrion|integral to membrane
YBR292C_d	YBR292C	YBR292C	hom	Dubious	0.536832150478155	0.295691780752664	no	1392	0.291331422973602	1019	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene	Unknown	Unknown	Unknown
YLR375W	YLR375W	STP3	hom	Verified	0.536816619448394	0.295697145295712	no	1393	0.309020071620308	1038	NA	FT		NUCLEUS		Zinc-finger protein of unknown function, possibly involved in pre-tRNA splicing and in uptake of branched-chain amino acids	biological_process	sequence-specific DNA binding	nucleus
YGL077C	YGL077C	HNM1	hom	Verified	0.536383989263408	0.295846597226023	no	1394	0.281231335410414	975	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Choline/ethanolamine transporter; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol	choline transport|ethanolamine transport|glycine betaine transport	choline transmembrane transporter activity|ethanolamine transmembrane transporter activity	integral to membrane|plasma membrane
YGR045C_d	YGR045C	YGR045C	hom	Dubious	0.535544724213218	0.29613661990365	no	1395	0.282401426633544	965	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKL164C	YKL164C	PIR1	hom	Verified	0.533824213408185	0.296731579884085	no	1396	0.285228416783568	967	NA	FT	PROTEIN LOCALIZATION|CELL WALL ORG/BIOGENESIS			O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle; PIR1 has a paralog, YJL160C, that arose from the whole genome duplication	intracellular protein transport|fungal-type cell wall organization	structural constituent of cell wall	fungal-type cell wall
YGR202C	YGR202C	PCT1	hom	Verified	0.533382185544224	0.296884523326319	no	1397	0.267293176701572	933	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS		Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; contains an element within the regulatory domain involved in both silencing and activation of enzymatic activity	phosphatidylcholine biosynthetic process|CDP-choline pathway	choline-phosphate cytidylyltransferase activity	nuclear envelope|Golgi apparatus|nucleus
YBL002W	YBL002W	HTB2	hom	Verified	0.533062189498833	0.296995265766976	no	1398	0.27745781882211	951	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB1; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation	chromatin assembly or disassembly	DNA binding	replication fork protection complex|nuclear nucleosome
YPL260W	YPL260W	YPL260W	hom	Verified	0.532344346410324	0.297243761598553	no	1399	0.318353018640647	1094	NA	FT		NUCLEUS		Putative substrate of cAMP-dependent protein kinase (PKA); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YPL260W is not an essential gene; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YLR401C	YLR401C	DUS3	hom	Verified	0.532126664546133	0.297319135328648	no	1400	0.242459179337668	823	NA	FT	RNA PROCESSING|OXIDATION-REDUCTION PROCESS	NUCLEUS		Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress	tRNA modification	tRNA dihydrouridine synthase activity	nucleus|cytoplasm
YAR015W	YAR015W	ADE1	hom	Verified	0.530887210679881	0.297748470431544	no	1401	0.294897894545345	993	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase, required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine; protein abundance increases in response to DNA replication stress	purine nucleotide biosynthetic process|'de novo' IMP biosynthetic process	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity	nucleus|cytoplasm
YJR116W_p	YJR116W	TDA4	hom	Uncharacterized	0.530501754108525	0.297882046574814	no	1402	0.248523879728422	841	NA					Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele	biological_process	molecular_function	integral to membrane
YDR459C	YDR459C	PFA5	hom	Verified	0.53042017023716	0.297910322157737	no	1403	0.277471524684749	952	NA	FT		PLASMA MEMBRANE		Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain	protein palmitoylation	palmitoyltransferase activity	integral to membrane|plasma membrane
YDR291W	YDR291W	HRQ1	hom	Verified	0.530380384862925	0.297924111535973	no	1404	0.289257131110608	949	NA	FT		NUCLEUS		3'-5'DNA helicase that has DNA strand annealing activity; helicase activity is stimulated by fork structure and 3'-tail length of substrates; belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity; similar to the human RecQ4p implicated in Rothmund-Thomson syndrome(RTS)	biological_process	molecular_function	nucleus
YDR215C_d	YDR215C	YDR215C	hom	Dubious	0.529746616046241	0.298143811330246	no	1405	0.300680982245665	979	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein	Unknown	Unknown	Unknown
YDR124W_p	YDR124W	YDR124W	hom	Uncharacterized	0.529468924278513	0.29824009810916	no	1406	0.285666008853942	955	NA					Putative protein of unknown function; non-essential gene; expression is strongly induced by alpha factor	biological_process	molecular_function	cellular_component
YGL159W_p	YGL159W	YGL159W	hom	Uncharacterized	0.529422319940893	0.298256259073925	no	1407	0.31150171279004	1079	NA					Putative protein of unknown function; deletion mutant has no detectable phenotype	biological_process	molecular_function	cellular_component
YPR115W	YPR115W	RGC1	hom	Verified	0.528893384702985	0.298439705641977	no	1408	0.305507135690117	1026	NA	FT	CELL CYCLE			Pleckstrin homology domain containing protein; proposed to function as a glycerol channel activator; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; RGC1 has a paralog, ASK10, that arose from the whole genome duplication	positive regulation of glycerol transport	molecular_function	cytoplasm
YKR067W	YKR067W	GPT2	hom	Verified	0.52880406379138	0.298470689198003	no	1409	0.312603453791045	1093	NA	FT	LIPID METABOLISM	ENDOPLASMIC RETICULUM		Glycerol-3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis; the most conserved motifs and functionally relevant residues are oriented towards the ER lumen	phospholipid biosynthetic process	glycerol-3-phosphate O-acyltransferase activity|glycerone-phosphate O-acyltransferase activity	integral to membrane|lipid particle|endoplasmic reticulum|cytoplasm
YLR460C_p	YLR460C	YLR460C	hom	Uncharacterized	0.528526232102449	0.298567072554859	no	1410	0.276121596457621	943	NA	FT	OXIDATION-REDUCTION PROCESS			Member of the quinone oxidoreductase family, up-regulated in response to the fungicide mancozeb; possibly up-regulated by iodine	biological_process	molecular_function	cellular_component
YLR444C_d	YLR444C	YLR444C	hom	Dubious	0.527843747315918	0.298803895311042	no	1411	0.288669937005808	987	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR151C	YLR151C	PCD1	hom	Verified	0.527403718425872	0.298956630929563	no	1412	0.298375430749217	989	NA	FT	NUCLEOTIDE METABOLISM			Peroxisomal pyrophosphatase with specificity for coenzyme A and CoA derivatives, may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids; nudix hydrolase family member	biological_process	pyrophosphatase activity	peroxisome
YGR178C	YGR178C	PBP1	hom	Verified	0.526887110038301	0.299135992807867	no	1413	0.306015833700281	1062	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION	NUCLEUS|MITOCHONDRION		Component of glucose deprivation induced stress granules; involved in P-body-dependent granule assembly; similar to human ataxin-2; interacts with Pab1p to regulate mRNA polyadenylation; interacts with Mkt1p to regulate HO translation; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress	positive regulation of translation|mRNA polyadenylation|stress granule assembly	molecular_function	mitochondrion|nucleus|polysome|cytoplasmic stress granule|cytoplasm
YKR061W	YKR061W	KTR2	hom	Verified	0.526414999331783	0.29929994818484	no	1414	0.285381028156058	974	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Mannosyltransferase involved in N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR2 has a paralog, YUR1, that arose from the whole genome duplication	cell wall mannoprotein biosynthetic process|protein N-linked glycosylation	mannosyltransferase activity	Golgi apparatus
YOR354C	YOR354C	MSC6	hom	Verified	0.525858351005483	0.299493314273846	no	1415	0.307917879348972	1046	NA	FT	CELL CYCLE	MITOCHONDRION		Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	reciprocal meiotic recombination	molecular_function	mitochondrion
YBR056W-A_p	YBR056W-A	YBR056W-A	hom	Uncharacterized	0.524597146938369	0.299931635255635	no	1416	0.332221193809109	1089	NA					Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the dubious ORF YBR056C-B	biological_process	molecular_function	cellular_component
YJL077C	YJL077C	ICS3	hom	Verified	0.524126216870581	0.300095377495021	no	1417	0.304508695236006	1056	NA					Protein of unknown function; may play a role in vacuolar sorting, null mutants are hypersensitive to sortin2	biological_process	molecular_function	cellular_component
YIL065C	YIL065C	FIS1	hom	Verified	0.524050102416595	0.300121846262389	no	1418	0.293407225954709	1022	NA	FT	MITOCHONDRION ORGANIZATION|PEROXISOME ORGANIZATION	MITOCHONDRION		Protein involved in mitochondrial membrane fission and peroxisome abundance; required for localization of Dnm1p and Mdv1p during mitochondrial division; mediates ethanol-induced apoptosis and ethanol-induced mitochondrial fragmentation	peroxisome fission|mitochondrial fission|chronological cell aging|peroxisome organization	molecular_function	mitochondrial outer membrane|mitochondrion|peroxisome
YDR134C	YDR134C	YDR134C	hom	pseudogene	0.523455965777231	0.300328493290848	no	1419	0.288276575303137	1001	NA					Hypothetical protein; YDR134C has a paralog, CCW12, that arose from the whole genome duplication	biological_process	molecular_function	fungal-type cell wall
YLR170C	YLR170C	APS1	hom	Verified	0.522434724396786	0.300683842048872	no	1420	0.317050134548379	1085	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex	Golgi to vacuole transport|vesicle-mediated transport	clathrin binding	AP-1 adaptor complex
YER007W	YER007W	PAC2	hom	Verified	0.522321700087451	0.300723181383149	no	1421	0.301896281720446	1040	NA	FT		CYTOSKELETON		Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl	protein folding|tubulin complex assembly|tubulin complex biogenesis	alpha-tubulin binding	cellular_component
YOL025W	YOL025W	LAG2	hom	Verified	0.522204971378945	0.300763812511546	no	1422	0.308860834982177	1032	NA	FT		MITOCHONDRION		Protein that negatively regulates the SCF E3-ubiquitin ligase by interacting with and preventing neddyation of the cullin subunit, Cdc53p; longevity determinant that is preferentially expressed in young cells; similar to mammalian Cand1	replicative cell aging|negative regulation of ubiquitin-protein ligase activity	molecular_function	mitochondrion
YKL070W_p	YKL070W	YKL070W	hom	Uncharacterized	0.521821500522495	0.300897309133978	no	1423	0.269885100700005	910	NA	FT	OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Putative protein of unknown function; expression induced in cells treated with mycotoxins patulin or citrinin; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YHR135C	YHR135C	YCK1	hom	Verified	0.521545258224146	0.300993493137808	no	1424	0.296593690206401	1023	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL DIVISION|PROTEIN PHOSPHORYLATION	ENDOPLASMIC RETICULUM|MITOCHONDRION|PLASMA MEMBRANE		Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; YCK1 has a paralog, YCK2, that arose from the whole genome duplication	cell morphogenesis|endocytosis|protein phosphorylation|cytokinesis|response to glucose stimulus	protein serine/threonine kinase activity|protein kinase activity	mitochondrion|endoplasmic reticulum|plasma membrane
YNL154C	YNL154C	YCK2	hom	Verified	0.521485635382495	0.301014254860494	no	1425	0.308215220518055	1077	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL DIVISION|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; YCK2 has a paralog, YCK1, that arose from the whole genome duplication	endocytosis|cell morphogenesis|protein phosphorylation|cytokinesis|response to glucose stimulus	protein serine/threonine kinase activity|protein kinase activity	plasma membrane|cellular bud neck|mating projection
YLR350W	YLR350W	ORM2	hom	Verified	0.521182445332873	0.301119840957826	no	1426	0.306511291883683	1048	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Evolutionarily conserved protein, similar to Orm1p; required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control; protein abundance increases in response to DNA replication stress	cellular sphingolipid homeostasis|negative regulation of sphingolipid biosynthetic process|response to unfolded protein	molecular_function	integral to membrane|endoplasmic reticulum|SPOTS complex
YNL191W	YNL191W	DUG3	hom	Verified	0.520506136005444	0.301355426155521	no	1427	0.292262178771321	992	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Component of glutamine amidotransferase (GATase II); forms a complex with Dug2p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)	glutathione catabolic process	peptidase activity|omega peptidase activity|gamma-glutamyltransferase activity|carbon-nitrogen ligase activity, with glutamine as amido-N-donor	cytoplasm
YML074C	YML074C	FPR3	hom	Verified	0.520294122403537	0.301429295930897	no	1428	0.279548691137838	940	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION	NUCLEUS		Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p	meiotic recombination checkpoint	peptidyl-prolyl cis-trans isomerase activity|macrolide binding	nucleolus
YFL012W_p	YFL012W	YFL012W	hom	Uncharacterized	0.519977159584988	0.301539747307854	no	1429	0.321086312427094	1086	NA					Putative protein of unknown function; transcribed during sporulation; null mutant exhibits increased resistance to rapamycin	biological_process	molecular_function	cellular_component
YER024W	YER024W	YAT2	hom	Verified	0.518384856793563	0.302094889050856	no	1430	0.303221549715569	1006	NA	FT	KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM			Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane	carnitine metabolic process|alcohol metabolic process	carnitine O-acetyltransferase activity	cytosol|cytoplasm
YLL015W	YLL015W	BPT1	hom	Verified	0.517893826616604	0.302266174739598	no	1431	0.266702740833258	902	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS			ABC type transmembrane transporter of MRP/CFTR family, found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p	cadmium ion transport|bilirubin transport	bilirubin transmembrane transporter activity|cadmium ion transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane
YER166W	YER166W	DNF1	hom	Verified	0.517854376547346	0.302279937968686	no	1432	0.315413338252103	1048	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION|GOLGI APPARATUS|PLASMA MEMBRANE		Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase	intracellular protein transport|phospholipid translocation|endocytosis|establishment or maintenance of cell polarity	phospholipid-translocating ATPase activity|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	mitochondrion|integral to membrane|plasma membrane
YBL028C	YBL028C	YBL028C	hom	Verified	0.516992112272952	0.302580832510423	no	1433	0.323413606495603	1082	NA	FT		NUCLEUS		Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis	biological_process	molecular_function	ribosome|nucleolus|nucleus|preribosome, large subunit precursor
YGR187C	YGR187C	HGH1	hom	Verified	0.516843823550343	0.30263259266182	no	1434	0.305909953497037	1022	NA					Nonessential protein of unknown function; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16); relative distribution to the nucleus increases upon DNA replication stress	biological_process	molecular_function	cytoplasm
YPR126C_d	YPR126C	YPR126C	hom	Dubious	0.516700923109279	0.302682475788092	no	1435	0.304077140001915	1003	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGR100W	YGR100W	MDR1	hom	Verified	0.515797465041671	0.302997936618855	no	1436	0.309516634124004	1063	NA	FT	PROTEIN LOCALIZATION|SIGNALING|NUCLEOTIDE METABOLISM			Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function	intracellular protein transport	Rab GTPase activator activity	cytoplasm
YDR401W_d	YDR401W	YDR401W	hom	Dubious	0.51556571763819	0.303078879660176	no	1437	0.318341436749341	1079	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPR188C	YPR188C	MLC2	hom	Verified	0.515459021985128	0.303116148790636	no	1438	0.298668069716114	1017	NA	FT	CELL CYCLE|CELL DIVISION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Regulatory light chain for the type II myosin, Myo1p; binds to an IQ motif of Myo1p, localization to the bud neck depends on Myo1p; involved in the disassembly of the Myo1p ring	actomyosin contractile ring contraction	myosin II binding	cellular bud neck contractile ring
YDL012C	YDL012C	YDL012C	hom	Verified	0.515293222021969	0.303174067311657	no	1439	0.268986580917383	939	NA	FT		PLASMA MEMBRANE		Tail-anchored plasma membrane protein with a conserved CYSTM module; possibly involved in response to stress; may contribute to non-homologous end-joining (NHEJ) based on ydl012c htz1 double null phenotype; YDL012C has a paralog, YBR016W, that arose from the whole genome duplication	biological_process	molecular_function	plasma membrane
YLR183C	YLR183C	TOS4	hom	Verified	0.51471235515879	0.303377019230861	no	1440	0.304143036245769	1042	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION|CHROMOSOME		Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; expression is periodic and peaks in G1; relative distribution to the nucleus increases upon DNA replication stress; TOS4 has a paralog, PLM2, that arose from the whole genome duplication	response to DNA damage stimulus	chromatin binding	nuclear chromatin|Rpd3L-Expanded complex|mitochondrion|nucleus|cytoplasm
YGR266W	YGR266W	YGR266W	hom	Verified	0.514529126902482	0.303441050842293	no	1441	0.292657107842529	1005	NA	FT		MITOCHONDRION|PLASMA MEMBRANE		Protein of unknown function; predicted to contain a single transmembrane domain; mutant has increased aneuploidy tolerance; localized to both the mitochondrial outer membrane and the plasma membrane; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion|plasma membrane
YOL056W	YOL056W	GPM3	hom	Verified	0.514310303639514	0.303517529523824	no	1442	0.303927283011387	1049	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event	biological_process	phosphoglycerate mutase activity|molecular_function	cytosol
YLR421C	YLR421C	RPN13	hom	Verified	0.514182325931448	0.303562261693538	no	1443	0.312095049815821	1080	NA	FT	PROTEOLYSIS	NUCLEUS		Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; protein abundance increases in response to DNA replication stress	ubiquitin-dependent protein catabolic process	ubiquitin binding	proteasome storage granule|proteasome regulatory particle, lid subcomplex
YOR301W	YOR301W	RAX1	hom	Verified	0.514083041200068	0.303596966807587	no	1444	0.263399527938506	879	NA	FT	CELL CYCLE|SIGNALING|CELL DIVISION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily	cellular bud site selection	molecular_function	integral to membrane|cellular bud neck
YGL243W	YGL243W	TAD1	hom	Verified	0.513905449274079	0.303659048726859	no	1445	0.288987614254951	963	NA	FT	RNA PROCESSING	NUCLEUS		tRNA-specific adenosine deaminase, deaminates adenosine-37 to inosine in tRNA-Ala	tRNA modification	tRNA-specific adenosine-37 deaminase activity	nucleus
YGR007W	YGR007W	ECT1	hom	Verified	0.513735318076835	0.303718527866717	no	1446	0.308337503455843	1022	NA	FT	LIPID METABOLISM	NUCLEUS		Ethanolamine-phosphate cytidylyltransferase, catalyzes the second step of phosphatidylethanolamine biosynthesis; involved in the maintenance of plasma membrane; similar to mammalian CTP: phosphocholine cytidylyl-transferases	phosphatidylethanolamine biosynthetic process	ethanolamine-phosphate cytidylyltransferase activity	nucleus|cytoplasm
YKR030W	YKR030W	GMH1	hom	Verified	0.513622253398096	0.30375805900025	no	1447	0.288223973691967	1012	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Golgi membrane protein of unknown function, interacts with Gea1p and Gea2p; required for localization of Gea2p; computational analysis suggests a possible role in either cell wall synthesis or protein-vacuolar targeting	transport	molecular_function	integral to membrane|integral to Golgi membrane
YOL080C	YOL080C	REX4	hom	Verified	0.512890758033176	0.304013869315576	no	1448	0.284772513232208	964	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Putative RNA exonuclease possibly involved in pre-rRNA processing and ribosome assembly	ribosomal large subunit assembly|rRNA processing	3'-5' exonuclease activity	nucleolus|nucleus
YKL033W-A_p	YKL033W-A	YKL033W-A	hom	Uncharacterized	0.512838398101806	0.304032183723335	no	1449	0.350329716164989	1172	NA					Putative protein of unknown function; similar to uncharacterized proteins from other fungi	biological_process	molecular_function	cellular_component
YDL138W	YDL138W	RGT2	hom	Verified	0.512131738450874	0.30427940656673	no	1450	0.280764803443911	920	NA	FT	SIGNALING	PLASMA MEMBRANE		Plasma membrane high glucose sensor that regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; RGT2 has a paralog, SNF3, that arose from the whole genome duplication	glucose transport|signal transduction|detection of glucose	glucose transmembrane transporter activity|receptor activity|glucose binding	integral to membrane|plasma membrane
YDR010C_d	YDR010C	YDR010C	hom	Dubious	0.51188867404696	0.304364462636573	no	1451	0.322896229191955	1081	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YJR110W	YJR110W	YMR1	hom	Verified	0.511791764796423	0.304398377258292	no	1452	0.30403845854389	1057	NA	FT	LIPID METABOLISM			Phosphatidylinositol 3-phosphate (PI3P) phosphatase; involved in various protein sorting pathways, including CVT targeting and endosome to vacuole transport; has similarity to the conserved myotubularin dual specificity phosphatase family	phosphatidylinositol dephosphorylation	mRNA binding|phosphatidylinositol-3-phosphatase activity	cytoplasm
YDL114W_p	YDL114W	YDL114W	hom	Uncharacterized	0.510171471629547	0.304965668404862	no	1453	0.309361669171543	1050	NA	FT	OXIDATION-REDUCTION PROCESS			Putative short-chain dehydrogenase/reductase; YDL114W is not an essential gene	biological_process	molecular_function	integral to membrane
YGL160W	YGL160W	AIM14	hom	Verified	0.509669826548102	0.305141397712349	no	1454	0.312871861808268	1069	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY			NADPH oxidase localized to the perinuclear ER; produces superoxide from NADPH; overexpression causes MCA1 dependent apoptosis; likely involved in superoxide-mediated regulation of the actin cytoskeleton; member of a conserved superfamily of NADPH oxidases (NOX enzymes); has similarity to iron/copper reductases (FRE1-8), particularly Fre8p	biological_process	oxidoreductase activity, oxidizing metal ions	integral to membrane|ribosome
YNL087W	YNL087W	TCB2	hom	Verified	0.509286118045353	0.305275843454964	no	1455	0.305807257491053	1033	NA	FT		ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains 3 calcium and lipid binding domains; mRNA is targeted to the bud	biological_process	lipid binding	cellular bud|cortical endoplasmic reticulum
YKL120W	YKL120W	OAC1	hom	Verified	0.50908387107289	0.305346718356496	no	1456	0.299235958579792	1022	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial inner membrane transporter, transports oxaloacetate, sulfate, thiosulfate, and isopropylmalate; member of the mitochondrial carrier family	sulfate transport|oxaloacetate transport|isopropylmalate transport	secondary active sulfate transmembrane transporter activity|oxaloacetate secondary active transmembrane transporter activity|isopropylmalate transmembrane transporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YFR045W_p	YFR045W	YFR045W	hom	Uncharacterized	0.508561079219547	0.30552995797767	no	1457	0.280684378061335	983	NA	FT		MITOCHONDRION		Putative mitochondrial transport protein; null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white	transport	transporter activity	integral to membrane|mitochondrial inner membrane
YDL222C	YDL222C	FMP45	hom	Verified	0.508445465978143	0.305570487237247	no	1458	0.280120913563313	955	NA	FT	CELL WALL ORG/BIOGENESIS	MITOCHONDRION|PLASMA MEMBRANE		Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C	fungal-type cell wall organization|ascospore formation	molecular_function	cell cortex|mitochondrion|integral to membrane|plasma membrane
YJL175W_d	YJL175W	YJL175W	hom	Dubious	0.508307093387351	0.305618998123204	no	1459	0.29803933448549	990	NA					Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor	Unknown	Unknown	Unknown
YDL144C	YDL144C	YDL144C	hom	Verified	0.508107994601456	0.305688804483321	no	1460	0.306379760201461	1051	NA	FT	OXIDATION-REDUCTION PROCESS	NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDL144C is not an essential gene; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YGR031W	YGR031W	IMO32	hom	Verified	0.507913965467908	0.305756840158897	no	1461	0.301246152025524	1025	NA	FT		MITOCHONDRION		Conserved mitochondrial protein of unknown function; processed by both mitochondrial processing peptidase and mitochondrial octapeptidyl aminopeptidase; gene contains the nested antisense gene NAG1	biological_process	molecular_function	mitochondrion
YCL064C	YCL064C	CHA1	hom	Verified	0.507769745704111	0.305807414687624	no	1462	0.307201975048499	1014	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine	threonine catabolic process|L-serine catabolic process	L-threonine ammonia-lyase activity|L-serine ammonia-lyase activity	mitochondrial nucleoid|mitochondrion
YMR316W	YMR316W	DIA1	hom	Verified	0.507324124277298	0.305963707193278	no	1463	0.323186661775348	1079	NA					Protein of unknown function, involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	pseudohyphal growth|invasive growth in response to glucose limitation	molecular_function	cytoplasm
YLR423C	YLR423C	ATG17	hom	Verified	0.507137825212726	0.306029058216098	no	1464	0.319604280310433	1070	NA	FT	MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION			Scaffold protein responsible for phagophore assembly site organization; regulatory subunit of an autophagy-specific complex that includes Atg1p and Atg13p; stimulates Atg1p kinase activity; human ortholog RB1CC1/FIP200 interacts with p53, which inhibits autophagy in human cells	piecemeal microautophagy of nucleus|mitochondrion degradation|peroxisome degradation|activation of protein kinase activity|autophagic vacuole assembly	protein kinase activator activity|protein complex scaffold	pre-autophagosomal structure|Atg1p signaling complex
YIL015W	YIL015W	BAR1	hom	Verified	0.507028758199507	0.306067320215753	no	1465	0.306205555417203	1026	NA	FT	SIGNALING|PROTEOLYSIS			Aspartyl protease secreted into the periplasmic space of mating type a cells, helps cells find mating partners, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|peptide catabolic process	aspartic-type endopeptidase activity	cell wall-bounded periplasmic space
YGR012W	YGR012W	YGR012W	hom	Verified	0.506406726401359	0.306285576771813	no	1466	0.294476711470253	985	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Putative cysteine synthase, localized to the mitochondrial outer membrane	cysteine biosynthetic process	cysteine synthase activity	mitochondrial outer membrane|mitochondrion
YIR017C	YIR017C	MET28	hom	Verified	0.505709971886803	0.306530133444251	no	1467	0.33086450734412	1121	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Basic leucine zipper (bZIP) transcriptional activator in the Cbf1p-Met4p-Met28p complex, participates in the regulation of sulfur metabolism	regulation of transcription from RNA polymerase II promoter|regulation of sulfur amino acid metabolic process|Unknown	RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YOR012W_p	YOR012W	YOR012W	hom	Uncharacterized	0.505674066767393	0.306542738262541	no	1468	0.259675288226105	869	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YBL012C_d	YBL012C	YBL012C	hom	Dubious	0.504992175528895	0.306782165806704	no	1469	0.306349436505033	1047	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YIL077C_p	YIL077C	YIL077C	hom	Uncharacterized	0.504931681385077	0.306803410661866	no	1470	0.323773089440339	1106	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)	biological_process	molecular_function	mitochondrion
YOL126C	YOL126C	MDH2	hom	Verified	0.504290974260481	0.307028459538155	no	1471	0.300756365313408	1003	NA	FT	PROTEIN LOCALIZATION|KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|PEROXISOME ORGANIZATION			Cytoplasmic malate dehydrogenase, one of three isozymes that catalyze interconversion of malate and oxaloacetate; involved in the glyoxylate cycle and gluconeogenesis during growth on two-carbon compounds; interacts with Pck1p and Fbp1	protein import into peroxisome matrix|gluconeogenesis|malate metabolic process	L-malate dehydrogenase activity	cytosol|cytoplasm
YGL181W	YGL181W	GTS1	hom	Verified	0.504021474795169	0.30712314316796	no	1472	0.312877445226884	1042	NA	FT	VESICLE-MEDIATED TRANSPORT|TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM|MEMBRANE ORGANIZATION|SIGNALING|NUCLEOTIDE METABOLISM	NUCLEUS|CYTOSKELETON		Protein involved in Arf3p regulation and in transcription regulation; localizes to the nucleus and to endocytic patches; contains an N-terminal Zn-finger and ArfGAP homology domain, a C-terminal glutamine-rich region, and a UBA (ubiquitin associated) domain; gts1 mutations affect budding, cell size, heat tolerance, sporulation, life span, ultradian rhythms, endocytosis; expression oscillates in a pattern similar to metabolic oscillations	endocytosis|ultradian rhythm|regulation of transcription from RNA polymerase II promoter|negative regulation of phosphatidylinositol biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	ARF GTPase activator activity|repressing transcription factor binding|transcription factor binding transcription factor activity	nucleus|cytoplasm|actin cortical patch
YFR039C_p	YFR039C	YFR039C	hom	Uncharacterized	0.503183570961243	0.30741760724957	no	1473	0.284267546853523	955	NA					Putative protein of unknown function; may be involved in response to high salt and changes in carbon source; deletion mutant has decreased spore survival in Drosophila feces	biological_process	molecular_function	cellular_component
YBR047W_p	YBR047W	FMP23	hom	Uncharacterized	0.502760556961392	0.307566314005799	no	1474	0.302869229256047	1039	NA	FT		MITOCHONDRION		Putative protein of unknown function; proposed to be involved in iron or copper homeostasis; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YMR129W	YMR129W	POM152	hom	Verified	0.502279091999499	0.307735607156631	no	1475	0.254676291941977	862	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CYTOSKELETON ORGANIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION	NUCLEAR PORE	Glycoprotein subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NUP210	nucleocytoplasmic transport|nuclear pore organization|protein import into nucleus|spindle pole body duplication associated with nuclear envelope	protein anchor|structural constituent of nuclear pore	mitochondrion|integral to membrane|nuclear pore transmembrane ring|nuclear envelope lumen|nuclear pore
YGR238C	YGR238C	KEL2	hom	Verified	0.501984432034912	0.307839235962487	no	1476	0.29618537819944	1020	NA	FT	CELL CYCLE	SITE OF POLARIZED GROWTH		Protein that functions in a complex with Kel1p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate	conjugation with cellular fusion|negative regulation of exit from mitosis	molecular_function	mating projection tip|cellular bud neck|cellular bud tip
YOR009W	YOR009W	TIR4	hom	Verified	0.501976891251931	0.307841888177632	no	1477	0.302377239230811	1014	NA	FT	CELL WALL ORG/BIOGENESIS			Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth; transcription is also induced by cold shock	biological_process	molecular_function	fungal-type cell wall
YBR194W	YBR194W	AIM4	hom	Verified	0.501951251622638	0.30785090612439	no	1478	0.34486288595386	1168	NA					Protein proposed to be associated with the nuclear pore complex; null mutant is viable, displays elevated frequency of mitochondrial genome loss and is sensitive to freeze-thaw stress	biological_process	molecular_function	cytoplasm
YLR036C_p	YLR036C	YLR036C	hom	Uncharacterized	0.501893235452588	0.307871311946611	no	1479	0.294887249247681	1029	NA					Putative protein of unknown function predicted to have transmembrane domains; interacts with HSP90 by yeast two-hybrid analysis; YLR036C is not an essential protein	biological_process	molecular_function	integral to membrane
YER011W	YER011W	TIR1	hom	Verified	0.501798149646448	0.307904757425708	no	1480	0.27964278953671	952	NA					Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking	response to stress	structural constituent of cell wall	fungal-type cell wall
YGR130C	YGR130C	YGR130C	hom	Verified	0.500965129803676	0.308197832010891	no	1481	0.327163548187091	1110	NA					Component of the eisosome with unknown function; GFP-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7)	biological_process	molecular_function	eisosome|membrane raft|cytoplasm
YML009C	YML009C	MRPL39	hom	Verified	0.500776839082088	0.308264093757336	no	1482	0.276145081974851	959	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YDL243C	YDL243C	AAD4	hom	Verified	0.500734837039843	0.308278875628433	no	1483	0.30352587255812	1029	NA	FT	OXIDATION-REDUCTION PROCESS			Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin	cellular aldehyde metabolic process	aryl-alcohol dehydrogenase (NAD+) activity	cellular_component
YNL101W	YNL101W	AVT4	hom	Verified	0.500351453327539	0.308413815069023	no	1484	0.29868610899593	1007	NA	FT	VACUOLAR TRANSPORT			Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters	amino acid export from vacuole	transporter activity|L-glutamine transmembrane transporter activity|L-isoleucine transmembrane transporter activity|L-tyrosine transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YCR067C	YCR067C	SED4	hom	Verified	0.500207334818292	0.308464547109449	no	1485	0.306744053439707	1010	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Integral endoplasmic reticulum membrane protein that stimulates Sar1p GTPase activity; involved in COPII vesicle budding through disassociation of coat proteins from membranes onto liposomes; binds Sec16p; similar to Sec12p	positive regulation of GTPase activity|regulation of COPII vesicle coating	Sar GTPase activator activity	integral to endoplasmic reticulum membrane
YCL056C	YCL056C	PEX34	hom	Verified	0.499360085467562	0.308762866475277	no	1486	0.301376976506273	1011	NA	FT	PEROXISOME ORGANIZATION			Peroxisomal integral membrane protein that regulates peroxisome populations; interacts with Pex11p, Pex25p, and Pex27p to control both constitutive peroxisome division and peroxisome morphology and abundance during peroxisome proliferation	peroxisome organization	molecular_function	integral to peroxisomal membrane|cytoplasm
YAL007C	YAL007C	ERP2	hom	Verified	0.499196625091909	0.308820435959421	no	1487	0.311910072389665	1074	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein that forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles	ER to Golgi vesicle-mediated transport	molecular_function	ER to Golgi transport vesicle
YMR261C	YMR261C	TPS3	hom	Verified	0.499092259384323	0.308857195214375	no	1488	0.301378349544536	1017	NA	FT	CARBOHYDRATE METABOLISM			Regulatory subunit of trehalose-6-phosphate synthase/phosphatase; involved in synthesis of storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; TPS3 has a paralog, TSL1, that arose from the whole genome duplication	trehalose biosynthetic process|response to stress	enzyme regulator activity|alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity|trehalose-phosphatase activity	alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
YDR058C	YDR058C	TGL2	hom	Verified	0.498834286789434	0.308948065462903	no	1489	0.31542227227932	1093	NA	FT	PROTEIN LOCALIZATION|LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		Triacylglycerol lipase that is localized to the mitochondria; has lipolytic activity towards triacylglycerols and diacylglycerols when expressed in E. coli	triglyceride catabolic process	triglyceride lipase activity	mitochondrion
YGL041C-B_p	YGL041C-B	YGL041C-B	hom	Uncharacterized	0.498427673523568	0.309091317784408	no	1490	0.297152084580317	1011	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YGR043C	YGR043C	NQM1	hom	Verified	0.497575241454561	0.309391728995496	no	1491	0.303191533556079	1045	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Transaldolase of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift	biological_process	sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity	nucleus
YLR348C	YLR348C	DIC1	hom	Verified	0.497388246685417	0.309457646107026	no	1492	0.301809545472046	985	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix	dicarboxylic acid transport	dicarboxylic acid transmembrane transporter activity	mitochondrial envelope|mitochondrion|integral to membrane
YGR213C	YGR213C	RTA1	hom	Verified	0.496080286799157	0.309918883476062	no	1493	0.280387426488083	953	NA	FT		PLASMA MEMBRANE		Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of protein	biological_process	molecular_function	integral to membrane|plasma membrane
YBR008C	YBR008C	FLR1	hom	Verified	0.496029066551499	0.309936951816533	no	1494	0.292493916355815	1001	NA	FT		PLASMA MEMBRANE		Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; expression induced in cells treated with the mycotoxin patulin; relocalizes from nucleus to plasma membrane upon DNA replication stress	drug transmembrane transport|transmembrane transport	fluconazole transporter activity|drug transmembrane transporter activity	integral to membrane|plasma membrane
YOR313C	YOR313C	SPS4	hom	Verified	0.495639052915763	0.310074547211284	no	1495	0.312878056668104	1054	NA	FT	CELL CYCLE			Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage	ascospore formation	molecular_function	cellular_component
YGR207C	YGR207C	CIR1	hom	Verified	0.495326692774317	0.310184765919321	no	1496	0.276541585732282	913	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Mitochondrial protein that interacts with frataxin (Yfh1p); putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-beta; may have a role in oxidative stress response	biological_process	molecular_function	mitochondrion
YCL076W_d	YCL076W	YCL076W	hom	Dubious	0.494773706386528	0.310379933288348	no	1497	0.281654511562402	957	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGR121C	YGR121C	MEP1	hom	Verified	0.494768006567686	0.310381945222972	no	1498	0.294067076313855	985	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation	nitrogen utilization|ammonium transport	ammonium transmembrane transporter activity	integral to membrane|plasma membrane
YDL113C	YDL113C	ATG20	hom	Verified	0.494539272562728	0.310462688938405	no	1499	0.296928757949369	1000	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Sorting nexin family member required for the cytoplasm-to-vacuole targeting (Cvt) pathway and for endosomal sorting; has a Phox homology domain that binds phosphatidylinositol-3-phosphate; interacts with Snx4p; potential Cdc28p substrate	mitochondrion degradation|early endosome to Golgi transport|macroautophagy|CVT pathway	phosphatidylinositol-3-phosphate binding	endosome|pre-autophagosomal structure|extrinsic to membrane
YOR300W_d	YOR300W	YOR300W	hom	Dubious	0.494169227049434	0.310593335334519	no	1500	0.296581288487895	1009	NA					Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7	Unknown	Unknown	Unknown
YNL051W	YNL051W	COG5	hom	Verified	0.493860625448759	0.310702306925703	no	1501	0.366762725657845	1224	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments	intra-Golgi vesicle-mediated transport|CVT pathway	molecular_function	Golgi transport complex
YGL148W	YGL148W	ARO2	hom	Verified	0.49379666676035	0.310724893721577	no	1502	0.38505855046241	1273	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM			Bifunctional chorismate synthase and flavin reductase; catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids; protein abundance increases in response to DNA replication stress	aromatic amino acid family biosynthetic process	chorismate synthase activity|riboflavin reductase (NADPH) activity	cytoplasm
YGR217W	YGR217W	CCH1	hom	Verified	0.493272012682845	0.310910200466252	no	1503	0.314968134151256	1070	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together	calcium ion transport	voltage-gated calcium channel activity|calcium channel activity	integral to membrane|plasma membrane
YMR030W	YMR030W	RSF1	hom	Verified	0.492993235017595	0.311008683682218	no	1504	0.291637048668135	993	NA	FT	TRANSCRIPTION FROM RNA POL II|SIGNALING|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS|MITOCHONDRION		Protein required for respiratory growth; localized to both the nucleus and mitochondrion; may interact with transcription factors to mediate the transition to respiratory growth and activate transcription of nuclear and mitochondrial genes	transcription from mitochondrial promoter|calcium-mediated signaling|transcription from RNA polymerase II promoter|aerobic respiration	molecular_function	mitochondrion|nucleus
YKR032W_d	YKR032W	YKR032W	hom	Dubious	0.492674411058926	0.311121330562408	no	1505	0.296694597076908	1023	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGL196W	YGL196W	DSD1	hom	Verified	0.492378122251761	0.311226031186736	no	1506	0.314026586463993	1085	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			D-serine dehydratase (aka D-serine ammonia-lyase); converts D-serine to pyruvate and ammonia by a reaction dependent on pyridoxal 5'-phosphate and zinc; may play a role in D-serine detoxification; L-serine is not a substrate	D-serine metabolic process	D-serine ammonia-lyase activity	cellular_component
YDR514C	YDR514C	YDR514C	hom	Verified	0.490780160965386	0.311790971598462	no	1507	0.304506321125794	1025	NA	FT		NUCLEUS|MITOCHONDRION		Protein of unknown function that localizes to mitochondria; overexpression affects endocytic protein trafficking; YDR514C has a paralog, GFD2, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrion|nucleus
YPL114W_d	YPL114W	YPL114W	hom	Dubious	0.490758660374544	0.311798575903774	no	1508	0.302111380093349	1044	NA					Dubious open reading frame, unlikely to encode a functional protein; largely overlaps ORF YPL113C; diploid deletion in BY4743 strain background exhibits high budding index	Unknown	Unknown	Unknown
YGL021W	YGL021W	ALK1	hom	Verified	0.49070536345013	0.311817426247323	no	1509	0.317575437494037	1052	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION			Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; ALK1 has a paralog, ALK2, that arose from the whole genome duplication; similar to mammalian haspins	mitosis|protein phosphorylation	protein serine/threonine kinase activity|protein kinase activity	cellular_component
YLR427W	YLR427W	MAG2	hom	Verified	0.490607867184968	0.311851910527759	no	1510	0.32853814006678	1130	NA					Cytoplasmic protein of unknown function; induced in response to mycotoxin patulin; ubiquitinated protein similar to the human ring finger motif protein RNF10; predicted to be involved in repair of alkylated DNA due to interaction with MAG1	biological_process	molecular_function	cytoplasm
YDL227C	YDL227C	HO	hom	Verified	0.490372018890156	0.311935336531202	no	1511	0.282647981571225	959	NA	FT		NUCLEUS		Site-specific endonuclease required for gene conversion at the MAT locus (homothallic switching) through the generation of a ds DNA break; expression restricted to mother cells in late G1 as controlled by Swi4p-Swi6p, Swi5p and Ash1p	mating type switching|gene conversion at mating-type locus, DNA double-strand break formation	endonuclease activity	nucleus
YDL080C	YDL080C	THI3	hom	Verified	0.490201377605509	0.311995703045079	no	1512	0.302976570047888	1018	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Probable alpha-ketoisocaproate decarboxylase, may have a role in catabolism of amino acids to long-chain and complex alcohols; required for expression of enzymes involved in thiamine biosynthesis	regulation of thiamine biosynthetic process|branched-chain amino acid catabolic process to alcohol via Ehrlich pathway|positive regulation of transcription from RNA polymerase II promoter|leucine catabolic process	carboxy-lyase activity	cytosol|nucleus
YFL004W	YFL004W	VTC2	hom	Verified	0.490052352113062	0.312048426829753	no	1513	0.306539413691473	1053	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	ENDOPLASMIC RETICULUM		Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion	polyphosphate metabolic process|vacuolar transport|microautophagy|protein localization|vacuole fusion, non-autophagic	molecular_function	fungal-type vacuole membrane|integral to membrane|endoplasmic reticulum|vacuolar transporter chaperone complex
YFL015C_d	YFL015C	YFL015C	hom	Dubious	0.489906845227628	0.312099909480418	no	1514	0.305171398936521	1003	NA					Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene	Unknown	Unknown	Unknown
YDL049C	YDL049C	KNH1	hom	Verified	0.489262472285259	0.312327942979998	no	1515	0.300230482429646	1041	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance	(1->6)-beta-D-glucan biosynthetic process	molecular_function	fungal-type cell wall|extracellular region
YDR452W	YDR452W	PPN1	hom	Verified	0.488957740621447	0.312435807793294	no	1516	0.359778932982228	1173	NA	FT		NUCLEUS		Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress	polyphosphate catabolic process|polyphosphate metabolic process	endopolyphosphatase activity|exopolyphosphatase activity	fungal-type vacuole membrane|nucleus
YPL035C_d	YPL035C	YPL035C	hom	Dubious	0.488681123284114	0.312533734993078	no	1517	0.31692460517715	1072	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene	Unknown	Unknown	Unknown
YDR444W_p	YDR444W	YDR444W	hom	Uncharacterized	0.487314476167976	0.313017745270046	no	1518	0.315538859180209	1060	NA	FT	LIPID METABOLISM			Putative hydrolase acting on ester bonds	biological_process	molecular_function	cytoplasm
YPL113C_p	YPL113C	YPL113C	hom	Uncharacterized	0.487077753622444	0.313101615456087	no	1519	0.282736239266416	976	NA	FT	OXIDATION-REDUCTION PROCESS			Glyoxylate reductase; acts on glyoxylate and hydroxypyruvate substrates; YPL113C is not an essential gene	metabolic process	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	cellular_component
YER119C	YER119C	AVT6	hom	Verified	0.486948305905345	0.313147482538056	no	1520	0.304912876649965	1048	NA	FT	VACUOLAR TRANSPORT			Vacuolar aspartate and glutamate exporter; member of a family of seven genes (AVT1-7) related to vesicular GABA-glycine transporters; involved in compartmentalizing acidic amino acids in response to nitrogen starvation; AVT6 has a paralog, AVT5, that arose from the whole genome duplication	amino acid export from vacuole|transmembrane transport	L-aspartate transmembrane transporter activity|transporter activity|L-glutamate transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YBR203W	YBR203W	COS111	hom	Verified	0.486746070198217	0.313219146303564	no	1521	0.354821226948059	1185	NA	FT	SIGNALING	MITOCHONDRION		Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	signal transduction	molecular_function	mitochondrion
YIR030C	YIR030C	DCG1	hom	Verified	0.486261235601248	0.313390979866807	no	1522	0.306922179372129	1071	NA					Protein of unknown function, expression is sensitive to nitrogen catabolite repression and regulated by Dal80p; contains transmembrane domain	nitrogen compound metabolic process	molecular_function	cellular_component
YPL021W	YPL021W	ECM23	hom	Verified	0.486033484244751	0.313471712779288	no	1523	0.287408021119935	977	NA	FT	CELL WALL ORG/BIOGENESIS			Non-essential protein of unconfirmed function; affects pre-rRNA processing, may act as a negative regulator of the transcription of genes involved in pseudohyphal growth; homologous to Srd1p	pseudohyphal growth	sequence-specific DNA binding	cellular_component
YMR300C	YMR300C	ADE4	hom	Verified	0.485661100068299	0.31360373413834	no	1524	0.322620820678937	1099	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM			Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway	'de novo' IMP biosynthetic process	amidophosphoribosyltransferase activity	cytoplasm
YDR504C	YDR504C	SPG3	hom	Verified	0.485105793021737	0.313800651490732	no	1525	0.295692392627913	1004	NA					Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources	biological_process	molecular_function	cellular_component
YJR128W_d	YJR128W	YJR128W	hom	Dubious	0.484311681845401	0.314082343311341	no	1526	0.304788380080674	1035	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSF2	Unknown	Unknown	Unknown
YOL105C	YOL105C	WSC3	hom	Verified	0.484309452201677	0.314083134376382	no	1527	0.296866434306	1041	NA	FT	SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|PEROXISOME ORGANIZATION	SITE OF POLARIZED GROWTH		Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity; involved in the response to heat shock and other stressors; regulates 1,3-beta-glucan synthesis	response to heat|peroxisome degradation|Rho protein signal transduction	transmembrane signaling receptor activity	mating projection tip
YBR244W	YBR244W	GPX2	hom	Verified	0.484220229406347	0.314114790822874	no	1528	0.276881926401625	946	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS|MITOCHONDRION		Phospholipid hydroperoxide glutathione peroxidase; protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; induced by glucose starvation; protein abundance increases in response to DNA replication stress	cellular response to oxidative stress	phospholipid-hydroperoxide glutathione peroxidase activity|glutathione peroxidase activity	extrinsic to mitochondrial inner membrane|extrinsic to mitochondrial outer membrane|nucleus|cytoplasm
YCL033C	YCL033C	MXR2	hom	Verified	0.483469586837264	0.314381174615881	no	1529	0.30718885635237	1027	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		Methionine-R-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR1; involved in the regulation of lifespan	cellular response to oxidative stress	peptide-methionine (R)-S-oxide reductase activity	mitochondrion
YER149C	YER149C	PEA2	hom	Verified	0.48317060547672	0.314487302363893	no	1530	0.28979503038532	976	NA	FT	CELL CYCLE|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Coiled-coil polarisome protein required for polarized morphogenesis, cell fusion, and low affinity Ca2+ influx; forms polarisome complex with Bni1p, Bud6p, and Spa2p; localizes to sites of polarized growth	bipolar cellular bud site selection|regulation of initiation of mating projection growth|regulation of termination of mating projection growth|actin filament organization|pseudohyphal growth|establishment of cell polarity|filamentous growth|Rho protein signal transduction	cytoskeletal regulatory protein binding	polarisome|actin cap|mating projection tip
YML016C	YML016C	PPZ1	hom	Verified	0.482388750681671	0.314764905458891	no	1531	0.330891038467904	1112	NA	FT	PROTEIN LOCALIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS	NUCLEUS|PLASMA MEMBRANE		Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance	cellular sodium ion homeostasis|cellular protein localization|protein dephosphorylation	protein serine/threonine phosphatase activity	extrinsic to plasma membrane|nucleus|cytoplasm
YGL051W	YGL051W	MST27	hom	Verified	0.481962494974671	0.314916294690453	no	1532	0.294566329056239	1025	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS|PLASMA MEMBRANE		Putative integral membrane protein, involved in vesicle formation; forms complex with Mst28p; member of DUP240 gene family; binds COPI and COPII vesicles	vesicle organization	molecular_function	integral to membrane|Golgi apparatus|endoplasmic reticulum|plasma membrane
YIL165C_p	YIL165C	YIL165C	hom	Uncharacterized	0.4814206481697	0.315108782223102	no	1533	0.298140792492906	972	NA					Putative protein of unknown function; mutant exhibits mitophagy defects; in closely related species and other S. cerevisiae strain backgrounds YIL165C and adjacent ORF, YIL164C, likely constitute a single ORF encoding a nitrilase gene	mitochondrion degradation	molecular_function	cellular_component
YML071C	YML071C	COG8	hom	Verified	0.479639203462286	0.315741982526884	no	1534	0.404468747869647	1327	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments	intra-Golgi vesicle-mediated transport|CVT pathway	molecular_function	Golgi transport complex
YDR426C_d	YDR426C	YDR426C	hom	Dubious	0.479591941531527	0.315758788780277	no	1535	0.289023686090052	926	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SNX41	Unknown	Unknown	Unknown
YDR528W	YDR528W	HLR1	hom	Verified	0.479440690746339	0.315812575834241	no	1536	0.296666443529307	985	NA	FT	CELL WALL ORG/BIOGENESIS			Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A; <br>HLR1 has a paralog, LRE1, that arose from the whole genome duplication	fungal-type cell wall organization	molecular_function	cytoplasm
YPR195C_d	YPR195C	YPR195C	hom	Dubious	0.4791599161076	0.315912433858925	no	1537	0.300200925056459	1017	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOR233W	YOR233W	KIN4	hom	Verified	0.479039770722644	0.315955167894428	no	1538	0.290749024630148	1007	NA	FT	CELL CYCLE|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Serine/threonine protein kinase; inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck; KIN4 has a paralog, FRK1, that arose from the whole genome duplication	mitotic cell cycle spindle orientation checkpoint|protein phosphorylation	protein serine/threonine kinase activity|protein kinase activity	cell cortex|spindle pole body|cellular bud neck
YGR197C	YGR197C	SNG1	hom	Verified	0.478493158574118	0.316149621245148	no	1539	0.303758054762325	1033	NA	FT		PLASMA MEMBRANE		Protein involved in resistance to nitrosoguanidine (MNNG) and 6-azauracil (6-AU); expression is regulated by transcription factors involved in multidrug resistance	nucleobase-containing compound transport	molecular_function	integral to membrane|plasma membrane
YPL264C_p	YPL264C	YPL264C	hom	Uncharacterized	0.478322989013134	0.316210168230489	no	1540	0.303359378756732	1015	NA					Putative membrane protein of unknown function; physically interacts with Hsp82p; YPL264C is not an essential gene	biological_process	molecular_function	integral to membrane
YGL210W	YGL210W	YPT32	hom	Verified	0.478214782831866	0.316248670970033	no	1541	0.287976125048764	970	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING	ENDOMEMBRANE SYSTEM|MITOCHONDRION|GOLGI APPARATUS		Rab family GTPase involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; protein abundance increases in response to DNA replication stress; YPT32 has a paralog, YPT31, that arose from the whole genome duplication	early endosome to Golgi transport|vesicle-mediated transport|exocytosis	GTPase activity	endosome|mitochondrial outer membrane|Golgi apparatus
YBR045C	YBR045C	GIP1	hom	Verified	0.478042776342066	0.316309879717294	no	1542	0.327528416752847	1091	NA	FT	CELL WALL ORG/BIOGENESIS			Meiosis-specific regulatory subunit of the Glc7p protein phosphatase, regulates spore wall formation and septin organization, required for expression of some late meiotic genes and for normal localization of Glc7p	ascospore wall assembly|regulation of phosphoprotein phosphatase activity	protein phosphatase type 1 regulator activity|protein phosphatase 1 binding	protein phosphatase type 1 complex|prospore membrane
YMR184W	YMR184W	ADD37	hom	Verified	0.477182303528863	0.316616155698484	no	1543	0.313425840944252	1049	NA	FT	PROTEOLYSIS			Protein of unknown function; involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene; protein abundance increases in response to DNA replication stress	ER-associated protein catabolic process	molecular_function	cytoplasm
YEL022W	YEL022W	GEA2	hom	Verified	0.476909176790762	0.316713398511233	no	1544	0.336786281083552	1135	NA	FT	VESICLE-MEDIATED TRANSPORT|SIGNALING|CYTOSKELETON ORGANIZATION|RESPONSE TO NUTRIENT LEVELS	GOLGI APPARATUS		Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA2 has a paralog, GEA1, that arose from the whole genome duplication	retrograde vesicle-mediated transport, Golgi to ER|secretory granule organization|ER to Golgi vesicle-mediated transport|macroautophagy|intra-Golgi vesicle-mediated transport|actin cytoskeleton organization	ARF guanyl-nucleotide exchange factor activity	integral to membrane|Golgi cis cisterna|extrinsic to membrane
YNL297C	YNL297C	MON2	hom	Verified	0.473937802141721	0.317772130680388	no	1545	0.36068282271177	1190	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Peripheral membrane protein with a role in endocytosis and vacuole integrity, interacts with Arl1p and localizes to the endosome; member of the Sec7p family of proteins	transport|endocytosis|protein targeting to vacuole|Golgi to endosome transport	guanyl-nucleotide exchange factor activity	cytosol|endosome|trans-Golgi network|extrinsic to membrane
YER158C_p	YER158C	YER158C	hom	Uncharacterized	0.473929829813846	0.317774973315179	no	1546	0.293340614617263	1008	NA					Protein of unknown function; potentially phosphorylated by Cdc28p; YER158C has a paralog, AFR1, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YLR385C	YLR385C	SWC7	hom	Verified	0.472634068099194	0.318237136253272	no	1547	0.309905782640387	1060	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin	chromatin remodeling	molecular_function	Swr1 complex|nucleus
YBL029W_p	YBL029W	YBL029W	hom	Uncharacterized	0.472117058907125	0.318421618415226	no	1548	0.329554812492069	1120	NA	FT		NUCLEUS		Non-essential protein of unknown function	biological_process	molecular_function	nucleus|cytoplasm
YOR118W	YOR118W	RTC5	hom	Verified	0.47208119200694	0.318434418317607	no	1549	0.338347978836266	1146	NA					Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity	biological_process	molecular_function	cytoplasm
YLR261C_d	YLR261C	VPS63	hom	Dubious	0.471412525250603	0.31867308661644	no	1550	0.394752840069421	1302	NA	FF				Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect	Unknown	Unknown	Unknown
YKL010C	YKL010C	UFD4	hom	Verified	0.470446614755809	0.319017983429949	no	1551	0.321188885742667	1064	NA	FT	PROTEOLYSIS	MITOCHONDRION		Ubiquitin-protein ligase (E3); interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins; relative distribution to the nucleus increases upon DNA replication stress	protein monoubiquitination|protein polyubiquitination	ubiquitin-protein ligase activity	mitochondrion|cytoplasm
YJR135C	YJR135C	MCM22	hom	Verified	0.469864127328433	0.319226047491525	no	1552	0.31002081341104	1037	NA	FT	CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME	KINETOCHORE	Outer kinetochore protein and component of the Ctf3 subcomplex; binds to centromeric DNA in a Ctf19p-dependent manner; involved in chromosome segregation and minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-K and fission yeast sim4	chromosome segregation|establishment of mitotic sister chromatid cohesion	molecular_function	condensed nuclear chromosome kinetochore
YDR031W	YDR031W	MIC14	hom	Verified	0.469731161426853	0.319273550795649	no	1553	0.303118237553585	959	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS|MITOCHONDRION		Mitochondrial intermembrane space protein of unknown function; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress	aerobic respiration	molecular_function	nucleus|mitochondrial intermembrane space|cytoplasm
YML066C	YML066C	SMA2	hom	Verified	0.469279520091382	0.319434926011528	no	1554	0.28997237769533	982	NA	FT	MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS	ENDOPLASMIC RETICULUM		Meiosis-specific prospore membrane protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation	ascospore wall assembly|spore membrane bending pathway	molecular_function	integral to membrane|prospore membrane|cytoplasm
YCR065W	YCR065W	HCM1	hom	Verified	0.46912412104931	0.319490459296236	no	1555	0.31896328672578	1119	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|RESPONSE TO OXIDATIVE STRESS	NUCLEUS|CHROMOSOME		Forkhead transcription factor that drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere maintenance role	positive regulation of transcription involved in S-phase of mitotic cell cycle|cellular response to oxidative stress|mitochondrion organization|spindle pole body organization|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding	nuclear chromatin|nucleus|cytoplasm
YCL047C	YCL047C	POF1	hom	Verified	0.468731492877994	0.319630786638549	no	1556	0.329730714501104	1109	NA	FT	PROTEOLYSIS			ATPase involved in the protein quality control and filamentation pathways; interacts physically with Kss1p and suppresses the filamentation defect of a kss1 deletion; also interacts with Ubc7p	pseudohyphal growth|ER-associated protein catabolic process|invasive growth in response to glucose limitation	ATPase activity	cellular_component
YOL084W	YOL084W	PHM7	hom	Verified	0.468380385685547	0.319756296043687	no	1557	0.280707778616199	949	NA	FT		PLASMA MEMBRANE		Protein of unknown function; expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YLR034C	YLR034C	SMF3	hom	Verified	0.467831555028953	0.319952526505339	no	1558	0.316846556604541	1053	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteins; protein abundance increases in response to DNA replication stress	cellular iron ion homeostasis|iron ion transport	metal ion transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane
YGR276C	YGR276C	RNH70	hom	Verified	0.467661363471619	0.320013387512996	no	1559	0.317296723321666	1055	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		3'-5' exoribonuclease; required for maturation of 3' ends of 5S rRNA and tRNA-Arg3 from dicistronic transcripts	U5 snRNA 3'-end processing|generation of mature 3'-end of 5S rRNA generated by RNA polymerase III|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|tRNA 3'-trailer cleavage, exonucleolytic	3'-5'-exoribonuclease activity|3'-5' exonuclease activity	nucleus
YPR194C	YPR194C	OPT2	hom	Verified	0.466869167911903	0.320296742735085	no	1560	0.310850741998516	1065	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION	PLASMA MEMBRANE		Oligopeptide transporter; member of the OPT family, with potential orthologs in S. pombe and C. albicans; also plays a role in formation of mature vacuoles	oligopeptide transport|vacuole fusion, non-autophagic	oligopeptide transporter activity	integral to membrane|integral to plasma membrane
YHR149C	YHR149C	SKG6	hom	Verified	0.463802804274975	0.321394517013058	no	1561	0.32459169813067	1080	NA	FT		SITE OF POLARIZED GROWTH		Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p	biological_process	molecular_function	cell cortex|incipient cellular bud site|integral to membrane|cellular bud neck|cellular bud tip
YML029W	YML029W	USA1	hom	Verified	0.463727316016183	0.321421561943748	no	1562	0.308455769277539	1035	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM	UBIQUITIN LIGASE COMPLEX	Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p	ER-associated protein catabolic process|mRNA splicing, via spliceosome|positive regulation of protein oligomerization	protein complex scaffold	Hrd1p ubiquitin ligase ERAD-L complex|endoplasmic reticulum membrane
YGR017W_p	YGR017W	YGR017W	hom	Uncharacterized	0.463174289489098	0.321619721808624	no	1563	0.295808375444366	969	NA	FT	OXIDATION-REDUCTION PROCESS	NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm	biological_process	molecular_function	nucleus|cytoplasm
YGL125W	YGL125W	MET13	hom	Verified	0.463054441239936	0.321662672397576	no	1564	0.333323950757301	1100	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Major isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway	methionine biosynthetic process	methylenetetrahydrofolate reductase (NADPH) activity	mitochondrion
YGR084C	YGR084C	MRP13	hom	Verified	0.462234457740997	0.321956597716635	no	1565	0.307807281916794	1032	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YKL026C	YKL026C	GPX1	hom	Verified	0.461703671150342	0.322146919034212	no	1566	0.3272025611234	1087	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS			Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress	cellular response to oxidative stress|peroxisome organization	phospholipid-hydroperoxide glutathione peroxidase activity|glutathione peroxidase activity	extrinsic to mitochondrial outer membrane|peroxisomal matrix
YBR006W	YBR006W	UGA2	hom	Verified	0.461319298265689	0.322284770693168	no	1567	0.39014471098786	1274	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS			Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm	cellular response to oxidative stress|gamma-aminobutyric acid catabolic process|glutamate decarboxylation to succinate	succinate-semialdehyde dehydrogenase [NAD(P)+] activity	cytoplasm
YGR205W	YGR205W	TDA10	hom	Verified	0.461164900758899	0.322340150765207	no	1568	0.298204390684044	999	NA	FT		NUCLEUS		ATP-binding protein of unknown function; crystal structure resembles that of E.coli pantothenate kinase and other small kinases; null mutant is sensitive to expression of the top1-T722A allele	biological_process	ATP binding	nucleus|cytoplasm
YPL198W	YPL198W	RPL7B	hom	Verified	0.460994730278684	0.322401192934612	no	1569	0.3268073624971	1119	NA	FT	TRANSLATION	NUCLEUS	RIBOSOME	Ribosomal 60S subunit protein L7B; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7B has a paralog, RPL7A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit|nucleolus|cytoplasm
YDL186W_p	YDL186W	YDL186W	hom	Uncharacterized	0.458771015798899	0.32319930533617	no	1570	0.318278774607308	1053	NA					Putative protein of unknown function; YDL186W is not an essential gene	biological_process	molecular_function	cellular_component
YPR154W	YPR154W	PIN3	hom	Verified	0.458529800769802	0.323285928749341	no	1571	0.326326917704848	1107	NA	FT	CYTOSKELETON ORGANIZATION	NUCLEUS		Protein that induces appearance of [PIN+] prion when overproduced	actin cytoskeleton organization	molecular_function	nucleus|cytoplasm
YKR024C	YKR024C	DBP7	hom	Verified	0.458503445698274	0.323295393774514	no	1572	0.326751085607191	1099	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis; essential for growth under anaerobic conditions	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	ATP-dependent RNA helicase activity	nucleolus
YOL159C	YOL159C	YOL159C	hom	Verified	0.458235140832098	0.323391757915819	no	1573	0.30479574523937	1018	NA					Soluble protein of unknown function; deletion mutants are viable and have elevated levels of Ty1 retrotransposition and Ty1 cDNA	biological_process	molecular_function	cellular_component
YJL145W	YJL145W	SFH5	hom	Verified	0.457945818912088	0.323495683800564	no	1574	0.302003122555158	1034	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Non-classical phosphatidylinositol transfer protein (PITP); exhibits PI- but not PC-transfer activity; localizes to the peripheral endoplasmic reticulum, cytosol and microsomes; similar to Sec14p; partially relocalizes to the plasma membrane upon DNA replication stress	Golgi to plasma membrane protein transport|phosphatidylinositol metabolic process|Unknown|regulation of exocytosis|phospholipid transport	phosphatidylinositol transporter activity|phosphatidylcholine transporter activity	cell periphery|cytosol|plasma membrane|cortical endoplasmic reticulum
YLR363C	YLR363C	NMD4	hom	Verified	0.45670669206664	0.323940940076727	no	1575	0.323361928719944	1104	NA					Protein that may be involved in nonsense-mediated mRNA decay; interacts with Nam7p, relocalizes from nucleus to cytoplasmic foci upon DNA replication stress	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	molecular_function	cytoplasm
YIL087C	YIL087C	AIM19	hom	Verified	0.456185785279736	0.32412819314108	no	1576	0.31447521686644	1083	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth	biological_process	molecular_function	mitochondrion
YEL014C_d	YEL014C	YEL014C	hom	Dubious	0.456082288011869	0.324165403141427	no	1577	0.305479886763513	1019	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKL043W	YKL043W	PHD1	hom	Verified	0.455295278310473	0.324448411345873	no	1578	0.2989630034478	977	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Transcriptional activator that enhances pseudohyphal growth; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate; PHD1 has a paralog, SOK2, that arose from the whole genome duplication	pseudohyphal growth|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YLL023C	YLL023C	POM33	hom	Verified	0.455059928545025	0.324533062683548	no	1579	0.315632463253698	1065	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	NUCLEAR PORE	Transmembrane nucleoporin; involved in nuclear pore complex (NPC) distribution, assembly or stabilization; highly conserved across species, orthologous to human TMEM33 and paralogous to Per33p; protein abundance increases in response to DNA replication stress	nuclear pore organization|nuclear pore complex assembly	structural constituent of nuclear pore	ribosome|integral to membrane|endoplasmic reticulum|nuclear pore
YER007C-A	YER007C-A	TMA20	hom	Verified	0.454002765454302	0.324913418177945	no	1580	0.312087410068816	1066	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION			Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; interacts with Tma22p; null mutant exhibits translation defects; has homology to human oncogene MCT-1; protein abundance increases in response to DNA replication stress	ribosome biogenesis	RNA binding	ribosome|cytoplasm
YJL142C_d	YJL142C	IRC9	hom	Dubious	0.453728655338271	0.325012069766152	no	1581	0.302012793095918	1039	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene YJL141C; null mutant displays increased levels of spontaneous Rad52p foci	Unknown	Unknown	Unknown
YKL062W	YKL062W	MSN4	hom	Verified	0.453526367810151	0.325084880442506	no	1582	0.326333277414079	1086	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Transcriptional activator; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression; MSN4 has a paralog, MSN2, that arose from the whole genome duplication	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription from RNA polymerase II promoter in response to a hypotonic environment|positive regulation of transcription from RNA polymerase II promoter in response to alkalinity|positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation|positive regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation|positive regulation of transcription from RNA polymerase II promoter in response to acidity|chromatin remodeling|regulation of replicative cell aging by regulation of transcription from RNA polymerase II promoter in response to caloric restriction|positive regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide|positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance|positive regulation of transcription from RNA polymerase II promoter in response to increased salt|cellular response to acidity|positive regulation of transcription from RNA polymerase II promoter in response to freezing|positive regulation of transcription from RNA polymerase II promoter in response to ethanol|replicative cell aging|age-dependent response to oxidative stress involved in chronological cell aging|positive regulation of transcription from RNA polymerase II promoter in response to hydrostatic pressure|positive regulation of transcription from RNA polymerase II promoter in response to nitrosative stress|positive regulation of transcription from RNA polymerase II promoter in response to cold|positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding	cytosol|nucleus
YIL042C	YIL042C	PKP1	hom	Verified	0.453265980630302	0.325178613140749	no	1583	0.311271050071686	1030	NA	FT	SIGNALING|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION	MITOCHONDRION		Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p	peptidyl-serine phosphorylation|protein phosphorylation|carbon utilization	protein kinase activity|pyruvate dehydrogenase (acetyl-transferring) kinase activity	mitochondrion
YER064C	YER064C	VHR2	hom	Verified	0.453162928136031	0.325215712448377	no	1584	0.308284590129782	1037	NA	FT		NUCLEUS		Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress	regulation of transcription, DNA-dependent	molecular_function	nucleus
YNL016W	YNL016W	PUB1	hom	Verified	0.453025913394868	0.325265040982984	no	1585	0.304628609673288	1040	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS	NUCLEUS		Poly (A)+ RNA-binding protein; abundant mRNP-component protein that binds mRNA and is required for stability of many mRNAs; component of glucose deprivation induced stress granules, involved in P-body-dependent granule assembly; protein abundance increases in response to DNA replication stress	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|stress granule assembly|regulation of mRNA stability	mRNA binding|poly(U) RNA binding	nucleus|cytoplasmic stress granule|cytoplasm
YJR154W_p	YJR154W	YJR154W	hom	Uncharacterized	0.452745063101755	0.325366163274763	no	1586	0.334682920762167	1092	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YDR102C_d	YDR102C	YDR102C	hom	Dubious	0.452498654482968	0.325454895169195	no	1587	0.313160167736276	1033	NA					Dubious open reading frame; homozygous diploid deletion strain exhibits high budding index	Unknown	Unknown	Unknown
YOL065C	YOL065C	INP54	hom	Verified	0.450884436147116	0.326036420696607	no	1588	0.301060429241701	995	NA	FT	PROTEIN LOCALIZATION|LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins	phosphatidylinositol dephosphorylation	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	endoplasmic reticulum
YLR021W	YLR021W	IRC25	hom	Verified	0.450062328220521	0.326332749599042	no	1589	0.331326762681081	1095	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS			Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions	proteasome assembly|chaperone-mediated protein complex assembly|nuclear-transcribed mRNA catabolic process, non-stop decay	molecular_function	intracellular
YOR382W	YOR382W	FIT2	hom	Verified	0.449909826606433	0.326387730887157	no	1590	0.292873161288363	968	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall	siderophore transport	molecular_function	fungal-type cell wall
YCR027C	YCR027C	RHB1	hom	Verified	0.449564417059064	0.326512275069383	no	1591	0.329484347676534	1117	NA	FT	VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM	PLASMA MEMBRANE		Putative Rheb-related GTPase involved in regulating canavanine resistance and arginine uptake; member of the Ras superfamily of G-proteins	lysine transport|retrograde transport, endosome to Golgi|arginine transport	GTPase activity	extrinsic to plasma membrane
YJR056C	YJR056C	YJR056C	hom	Verified	0.449360934499589	0.326585653748292	no	1592	0.281135951976106	987	NA	FT		NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YFL041W	YFL041W	FET5	hom	Verified	0.447667124047266	0.327196725832398	no	1593	0.307991524028798	1067	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS	PLASMA MEMBRANE		Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport	iron ion transport	ferroxidase activity	fungal-type vacuole membrane|integral to membrane
YFR054C_d	YFR054C	YFR054C	hom	Dubious	0.447431328591596	0.327281830001577	no	1594	0.300124915429115	1036	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YML052W	YML052W	SUR7	hom	Verified	0.447374681656782	0.327302276560914	no	1595	0.302638919433597	1047	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	MITOCHONDRION|PLASMA MEMBRANE		Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants	endocytosis|ascospore formation	molecular_function	cell cortex|eisosome|mitochondrion|membrane raft|integral to membrane|plasma membrane|actin cortical patch
YER067C-A_d	YER067C-A	YER067C-A	hom	Dubious	0.447202930274544	0.327364272929174	no	1596	0.308502039207151	1018	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W	Unknown	Unknown	Unknown
YDR330W	YDR330W	UBX5	hom	Verified	0.445647033428223	0.32792611520484	no	1597	0.310273285331159	1044	NA	FT	PROTEOLYSIS	NUCLEUS		UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p	proteasomal ubiquitin-dependent protein catabolic process	molecular_function	nucleus|cytoplasm
YFL021W	YFL021W	GAT1	hom	Verified	0.445097489758832	0.328124651409123	no	1598	0.303299608896737	1028	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Transcriptional activator of genes involved in nitrogen catabolite repression; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p	nitrogen catabolite activation of transcription from RNA polymerase II promoter|nitrogen catabolite activation of transcription	sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor binding transcription factor activity	cytosol|nucleus
YER188W_d	YER188W	YER188W	hom	Dubious	0.444885550661554	0.328201232615201	no	1599	0.382080224118524	1261	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; large-scale analyses show mRNA expression increases under anaerobic conditions and two-hybrid interactions with Sst2p	Unknown	Unknown	Unknown
YDR491C_d	YDR491C	YDR491C	hom	Dubious	0.444744699879706	0.328252131054629	no	1600	0.300353349453901	1014	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR098C	YDR098C	GRX3	hom	Verified	0.444064987921366	0.328497799473627	no	1601	0.320656714973582	1101	NA	FT	ION HOMEOSTASIS|CYTOSKELETON ORGANIZATION|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage; evidence exists indicating that the translation start site is not Met1 as currently annotated, but rather Met36	cellular iron ion homeostasis|cellular response to oxidative stress|actin cytoskeleton organization	disulfide oxidoreductase activity	cytosol|nucleus
YNL295W_p	YNL295W	YNL295W	hom	Uncharacterized	0.444028970507779	0.328510819323929	no	1602	0.300769706529156	1013	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YIL038C	YIL038C	NOT3	hom	Verified	0.443715183860861	0.328624258130185	no	1603	0.318743698716338	1086	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation	regulation of transcription from RNA polymerase II promoter|nuclear-transcribed mRNA poly(A) tail shortening|positive regulation of transcription elongation from RNA polymerase II promoter|protein ubiquitination	ubiquitin-protein ligase activity	CCR4-NOT core complex|cytoplasm
YOR230W	YOR230W	WTM1	hom	Verified	0.443702420076724	0.328628872773205	no	1604	0.310647965102453	1050	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CELL CYCLE|GENE SILENCING	NUCLEUS		Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; required for nuclear localization of the ribonucleotide reductase small subunit Rnr2p and Rnr4p; contains WD repeats	negative regulation of chromatin silencing at silent mating-type cassette|maintenance of protein location in nucleus|negative regulation of transcription from RNA polymerase II promoter during meiosis|negative regulation of chromatin silencing at telomere|protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter	protein binding|transcription corepressor activity	nucleus
YLR285C-A_p	YLR285C-A	YLR285C-A	hom	Uncharacterized	0.443655174632716	0.328645954209128	no	1605	0.316971597348037	1051	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YKR074W	YKR074W	AIM29	hom	Verified	0.443525731157135	0.328692755909039	no	1606	0.31104112689999	1077	NA					Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YKR074W is not an essential gene; null mutant displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	cytoplasm
YGL017W	YGL017W	ATE1	hom	Verified	0.442854381525489	0.328935532781338	no	1607	0.313173418400586	1053	NA	FT	PROTEOLYSIS			Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway	cellular protein modification process|protein arginylation	arginyltransferase activity	cytoplasm
YDR100W	YDR100W	TVP15	hom	Verified	0.442765711342832	0.328967603543252	no	1608	0.333636684252	1128	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p	vesicle-mediated transport	molecular_function	COPI-coated vesicle|integral to membrane|integral to Golgi membrane
YMR175W-A_p	YMR175W-A	YMR175W-A	hom	Uncharacterized	0.439979126304228	0.32997611278867	no	1609	0.309481355828895	1064	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YIL009W	YIL009W	FAA3	hom	Verified	0.439963738363813	0.329981685368706	no	1610	0.323796724473693	1105	NA	FT	KETONE METABOLISM|LIPID METABOLISM			Long chain fatty acyl-CoA synthetase, activates imported fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery	long-chain fatty acid metabolic process	long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity	cellular_component
YLR030W_p	YLR030W	YLR030W	hom	Uncharacterized	0.438464552907994	0.330524780265464	no	1611	0.307439167052475	1066	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YPR069C	YPR069C	SPE3	hom	Verified	0.438462895965347	0.330525380707225	no	1612	0.363352883033488	1203	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM	NUCLEUS		Spermidine synthase, involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells	spermidine biosynthetic process|pantothenate biosynthetic process	spermidine synthase activity	nucleus|cytoplasm
YMR243C	YMR243C	ZRC1	hom	Verified	0.437705928327709	0.330799735730518	no	1613	0.334238551964113	1123	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Vacuolar membrane zinc transporter; transports zinc from cytosol to vacuole for storage; also has role in resistance to zinc shock resulting from sudden influx of zinc into cytoplasm; human ortholog SLC30A10 functions as a Mn transporter and mutations in SLC30A10 cause neurotoxic accumulation of Mn in liver and brain; ZRC1 has a paralog, COT1, that arose from the whole genome duplication	cobalt ion transport|cellular zinc ion homeostasis|zinc ion transport|glutathione metabolic process	zinc ion transmembrane transporter activity|inorganic cation transmembrane transporter activity	integral to membrane|fungal-type vacuole
YDR171W	YDR171W	HSP42	hom	Verified	0.4374715991069	0.330884684346427	no	1614	0.311467566754854	1053	NA	FT	CYTOSKELETON ORGANIZATION	CYTOSKELETON		Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress	cytoskeleton organization	unfolded protein binding	cytoskeleton|chaperonin-containing T-complex|cytoplasm
YDL104C	YDL104C	QRI7	hom	Verified	0.437414464123957	0.330905398140399	no	1615	0.341559402530985	1117	NA	FT	RNA PROCESSING|PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Highly conserved mitochondrial protein, essential for t6A modification of mitochondrial tRNAs that decode ANN codons; similar to Kae1p and E. coli YgjD, both of which are also required for tRNA t6A modification	mitochondrial tRNA threonylcarbamoyladenosine modification	molecular_function	mitochondrion
YJL163C_p	YJL163C	YJL163C	hom	Uncharacterized	0.436893628076812	0.331094246607307	no	1616	0.319608419958117	1047	NA					Putative protein of unknown function	biological_process	molecular_function	integral to membrane
YIL084C	YIL084C	SDS3	hom	Verified	0.435490682256922	0.3316031504397	no	1617	0.342721137800355	1174	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Component of the Rpd3p/Sin3p deacetylase complex required for its structural integrity and catalytic activity, involved in transcriptional silencing and required for sporulation; cells defective in SDS3 display pleiotropic phenotypes	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of chromatin silencing at telomere|chromatin silencing|negative regulation of chromatin silencing at rDNA|positive regulation of transcription from RNA polymerase II promoter|histone deacetylation	histone deacetylase activity	Rpd3L-Expanded complex|Rpd3L complex
YOL104C	YOL104C	NDJ1	hom	Verified	0.435184756926641	0.331714162966841	no	1618	0.295361198078662	1003	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Meiosis-specific telomere protein, required for bouquet formation, effective homolog pairing, ordered cross-over distribution, sister chromatid cohesion at meiotic telomeres, chromosomal segregation and telomere-led rapid prophase movement	meiotic telomere clustering|synapsis|attachment of telomeric heterochromatin to nuclear envelope|regulation of reciprocal meiotic recombination|reciprocal meiotic recombination	telomeric DNA binding	nuclear chromosome, telomeric region
YAL062W	YAL062W	GDH3	hom	Verified	0.434712854416461	0.331885433375641	no	1619	0.318345364484367	1086	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	NUCLEUS|MITOCHONDRION		NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources; GDH3 has a paralog, GDH1, that arose from the whole genome duplication	glutamate biosynthetic process|ammonia assimilation cycle	glutamate dehydrogenase (NADP+) activity	mitochondrion|nucleus
YOR238W_p	YOR238W	YOR238W	hom	Uncharacterized	0.434620796206758	0.331918848710867	no	1620	0.32119016789172	1070	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YFR046C	YFR046C	CNN1	hom	Verified	0.433504196203526	0.332324259130219	no	1621	0.319823554002841	1093	NA	FT	CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME	KINETOCHORE	Kinetochore protein; associated with the essential kinetochore proteins Nnf1p and Spc24p; phosphorylated by Clb5-Cdk1, Mps1p, Ipl1p and to a lesser extent by Clb2-Cdk1; localizes to the lower region of the Ndc80 complex during anaphase and regulates KMN activity by inhibiting the Mtw1 and Spc105 complexes from binding to the Ndc80 complex; similar to metazoan CENP-T	chromosome segregation	molecular_function	nucleus|kinetochore
YKL127W	YKL127W	PGM1	hom	Verified	0.433039496947783	0.332493038042561	no	1622	0.307357560491688	1012	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism	glucose 6-phosphate metabolic process|galactose catabolic process|glucose 1-phosphate metabolic process|UDP-glucose metabolic process|trehalose biosynthetic process|glycogen biosynthetic process	phosphoglucomutase activity	cytoplasm
YML055W	YML055W	SPC2	hom	Verified	0.432418924939395	0.332718482949877	no	1623	0.348867341116983	1172	NA	FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC25	signal peptide processing|protein targeting to ER	peptidase activity	signal peptidase complex
YHR009C_p	YHR009C	TDA3	hom	Uncharacterized	0.432336501153396	0.332748430882168	no	1624	0.33737109564118	1132	NA	FT	VESICLE-MEDIATED TRANSPORT|OXIDATION-REDUCTION PROCESS			Putative oxidoreductase involved in late endosome to Golgi transport; physical and genetical interactions with Btn2p; null mutant is viable, has extended S phase, and sensitive to expression of top1-T722A allele; similar to human FOXRED1	retrograde transport, endosome to Golgi	molecular_function	late endosome|cytoplasm
YOR360C	YOR360C	PDE2	hom	Verified	0.431436512885565	0.333075502836122	no	1625	0.357175242438795	1179	NA	FT	SIGNALING	NUCLEUS		High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon	cAMP-mediated signaling	3',5'-cyclic-AMP phosphodiesterase activity	nucleus|cytoplasm
YLR241W_p	YLR241W	YLR241W	hom	Uncharacterized	0.430409126584398	0.33344902878503	no	1626	0.319797466705335	1079	NA					Putative protein of unknown function, may be involved in detoxification	biological_process	molecular_function	integral to membrane
YGR199W	YGR199W	PMT6	hom	Verified	0.429980364657558	0.333604962266701	no	1627	0.335785409323742	1139	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein O-mannosyltransferase, transfers mannose from dolichyl phosphate-D-mannose to protein serine/threonine residues of secretory proteins; reaction is essential for cell wall rigidity; member of a family of mannosyltransferases	protein O-linked glycosylation|protein O-linked mannosylation	dolichyl-phosphate-mannose-protein mannosyltransferase activity	integral to membrane
YMR230W	YMR230W	RPS10B	hom	Verified	0.429800911234338	0.33367023498632	no	1628	0.345645783190034	1167	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10B has a paralog, RPS10A, that arose from the whole genome duplication	cytoplasmic translation|rRNA export from nucleus	structural constituent of ribosome	cytosolic small ribosomal subunit
YDR320C	YDR320C	SWA2	hom	Verified	0.428688686858009	0.334074897373568	no	1629	0.371605891231108	1197	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|NUCLEOTIDE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles	positive regulation of ATPase activity|endoplasmic reticulum inheritance|clathrin coat disassembly	ubiquitin binding|clathrin binding	endoplasmic reticulum membrane
YDL151C_d	YDL151C	BUD30	hom	Dubious	0.428425342584029	0.334170738617131	no	1630	0.347733189444563	1160	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 96% of ORF overlaps the verified gene RPC53; diploid mutant displays a weak budding pattern phenotype in a systematic assay	Unknown	Unknown	Unknown
YOL109W	YOL109W	ZEO1	hom	Verified	0.428388002451105	0.334184329022091	no	1631	0.340027046565303	1119	NA	FT	CELL WALL ORG/BIOGENESIS	MITOCHONDRION|PLASMA MEMBRANE		Peripheral membrane protein of the plasma membrane that interacts with Mid2p; regulates the cell integrity pathway mediated by Pkc1p and Slt2p; the authentic protein is detected in a phosphorylated state in highly purified mitochondria	fungal-type cell wall organization|response to stress	molecular_function	mitochondrial outer membrane|mitochondrion|extrinsic to plasma membrane|plasma membrane
YNR075W	YNR075W	COS10	hom	Verified	0.428177378848136	0.334260992168442	no	1632	0.307228357633533	1035	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins	endocytosis	molecular_function	nuclear envelope|integral to membrane|endoplasmic reticulum|cytoplasm
YJR108W	YJR108W	ABM1	hom	Verified	0.428129541867931	0.334278404919526	no	1633	0.320951809046705	1083	NA	FT	CYTOSKELETON ORGANIZATION			Protein of unknown function, required for normal microtubule organization	microtubule cytoskeleton organization	molecular_function	cellular_component
YLR187W	YLR187W	SKG3	hom	Verified	0.427863097287386	0.334375397773813	no	1634	0.33494613806563	1100	NA	FT		SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate; similar to Skg4p; relocalizes from bud neck to cytoplasm upon DNA replication stress; SKG3 has a paralog, CAF120, that arose from the whole genome duplication	biological_process	molecular_function	cellular bud|cellular bud neck|cytoplasm
YMR104C	YMR104C	YPK2	hom	Verified	0.42647684947142	0.334880206840201	no	1635	0.296801006842869	1003	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION	NUCLEUS		Protein kinase with similarity to serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK; YPK2 has a paralog, YPK1, that arose from the whole genome duplication	eisosome assembly|protein phosphorylation	protein kinase activity	nucleus|cytoplasm
YDR351W	YDR351W	SBE2	hom	Verified	0.426399967430446	0.33490821256427	no	1636	0.33637657718751	1142	NA	FT	PROTEIN LOCALIZATION|CELL WALL ORG/BIOGENESIS	GOLGI APPARATUS		Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth	fungal-type cell wall organization	molecular_function	Golgi apparatus
YCR031C	YCR031C	RPS14A	hom	Verified	0.425193318268857	0.335347877327898	no	1637	0.334498173196721	1083	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION	NUCLEUS	RIBOSOME	Protein component of the small (40S) ribosomal subunit; required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; homologous to mammalian ribosomal protein S14 and bacterial S11; RPS14A has a paralog, RPS14B, that arose from the whole genome duplication	cytoplasmic translation|ribosomal small subunit assembly|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome|mRNA binding	small-subunit processome|cytosolic small ribosomal subunit|90S preribosome
YNR040W_p	YNR040W	YNR040W	hom	Uncharacterized	0.424738535953422	0.335513644183527	no	1638	0.340562874390001	1129	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YLR240W	YLR240W	VPS34	hom	Verified	0.424619478177733	0.335557045693048	no	1639	0.355203130777952	1196	NA	FT	PROTEIN LOCALIZATION|LIPID METABOLISM|SIGNALING|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION	GOLGI APPARATUS		Phosphatidylinositol (PI) 3-kinase that synthesizes PI-3-phosphate; forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting; activated by the GTP-bound form of Gpa1p; a fraction is localized, with Vps15p, to nuclear pores at nucleus-vacuole junctions and may facilitate transcription elongation for genes positioned at the nuclear periphery	peroxisome degradation|phosphatidylinositol phosphorylation|protein phosphorylation	1-phosphatidylinositol-3-kinase activity|protein kinase activity	endosome|fungal-type vacuole membrane|phosphatidylinositol 3-kinase complex I|phosphatidylinositol 3-kinase complex II|peroxisome|pre-autophagosomal structure
YAL064C-A_p	YAL064C-A	TDA8	hom	Uncharacterized	0.424382569899695	0.335643415137311	no	1640	0.316737596329271	1048	NA					Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene	biological_process	molecular_function	cellular_component
YOL160W_d	YOL160W	YOL160W	hom	Dubious	0.423801169490814	0.335855412575305	no	1641	0.315035647066927	1061	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YML011C	YML011C	RAD33	hom	Verified	0.42364716773864	0.335911575360958	no	1642	0.321311666417925	1053	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Protein involved in nucleotide excision repair; green fluorescent protein (GFP)-fusion protein localizes to the nucleus	nucleotide-excision repair	molecular_function	nucleus
YLR114C	YLR114C	AVL9	hom	Verified	0.423480463953196	0.335972374571867	no	1643	0.349031048367072	1160	NA	FT	VESICLE-MEDIATED TRANSPORT			Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress	post-Golgi vesicle-mediated transport	molecular_function	cytoplasm
YNL078W	YNL078W	NIS1	hom	Verified	0.421567888997592	0.336670224278204	no	1644	0.304399899564065	1060	NA	FT	CELL CYCLE	NUCLEUS|SITE OF POLARIZED GROWTH		Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network	regulation of mitosis	molecular_function	nucleus|cellular bud neck
YCR022C_d	YCR022C	YCR022C	hom	Dubious	0.421392749326549	0.336734156431216	no	1645	0.327544968449165	1065	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR022C is not an essential gene	Unknown	Unknown	Unknown
YMR092C	YMR092C	AIP1	hom	Verified	0.419962426629203	0.337256451106373	no	1646	0.33206763912258	1087	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON		Actin cortical patch component; interacts with the actin depolymerizing factor cofilin; required to restrict cofilin localization to cortical patches; contains WD repeats; protein increases in abundance and relocalizes from cytoplasm to plasma membrane upon DNA replication stress	actin filament depolymerization|response to osmotic stress	actin binding	nucleus|mating projection tip|cytoplasm|actin cortical patch
YPR012W_d	YPR012W	YPR012W	hom	Dubious	0.418660872341722	0.337731997627753	no	1647	0.336199376089625	1138	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR012W is not an essential gene	Unknown	Unknown	Unknown
YLR288C	YLR288C	MEC3	hom	Verified	0.41794445237014	0.337993865333929	no	1648	0.325717513874824	1062	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS|CHROMOSOME		DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1	telomere maintenance via recombination|DNA damage checkpoint|DNA metabolic process|chromatin silencing at telomere	DNA binding	nucleus|checkpoint clamp complex
YNL050C_p	YNL050C	YNL050C	hom	Uncharacterized	0.417778116594504	0.338054676044214	no	1649	0.346471111041999	1170	NA					Putative protein of unknown function; YNL050c is not an essential gene	biological_process	molecular_function	cellular_component
YDL135C	YDL135C	RDI1	hom	Verified	0.41732035980376	0.338222049201578	no	1650	0.317475398260391	1070	NA	FT	MEMBRANE ORGANIZATION|SIGNALING|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH		Rho GDP dissociation inhibitor; involved in the localization and regulation of Cdc42p and Rho1p; protein abundance increases in response to DNA replication stress	regulation of vacuole fusion, non-autophagic|actin filament organization|small GTPase mediated signal transduction	Rho GDP-dissociation inhibitor activity	cytosol|plasma membrane|cellular bud neck|cellular bud tip
YHL015W-A_p	YHL015W-A	YHL015W-A	hom	Uncharacterized	0.415833276080573	0.338766003654071	no	1651	0.32513547679568	1121	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YFL054C_p	YFL054C	YFL054C	hom	Uncharacterized	0.415344583130437	0.338944834212715	no	1652	0.331137224750823	1116	NA					Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol	water transport|transmembrane transport	water channel activity|glycerol transmembrane transporter activity|transporter activity	integral to membrane
YBR066C	YBR066C	NRG2	hom	Verified	0.415155204699678	0.339014144443154	no	1653	0.289457661693355	977	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Transcriptional repressor; mediates glucose repression and negatively regulates filamentous growth; NRG2 has a paralog, NRG1, that arose from the whole genome duplication	negative regulation of transcription from RNA polymerase II promoter by glucose|biofilm formation|pseudohyphal growth|Unknown	sequence-specific DNA binding	nucleus
YAR042W	YAR042W	SWH1	hom	Verified	0.414834979429859	0.339131355441625	no	1654	0.332119318156675	1125	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats; localizes to the Golgi and the nucleus-vacuole junction	endocytosis|maintenance of cell polarity|exocytosis|sterol transport	lipid binding|oxysterol binding|1-phosphatidylinositol binding|sterol transporter activity	nuclear envelope|endoplasmic reticulum|Golgi trans cisterna|early endosome
YJL151C	YJL151C	SNA3	hom	Verified	0.414565443845937	0.339230024731312	no	1655	0.335529346507128	1124	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM		Protein involved in efficient MVB sorting of proteins to the vacuole; may function as an RSP5 adapter protein for MVB cargos; integral membrane protein localized to vacuolar intralumenal vesicles	cellular protein catabolic process|endosome transport via multivesicular body sorting pathway	ubiquitin protein ligase binding	fungal-type vacuole lumen|integral to membrane
YOR252W	YOR252W	TMA16	hom	Verified	0.414116215456839	0.33939449893121	no	1656	0.332063887026424	1129	NA	FT		NUCLEUS		Protein of unknown function that associates with ribosomes	biological_process	molecular_function	ribosome|nucleus
YGR138C	YGR138C	TPO2	hom	Verified	0.413998910470152	0.339437452378179	no	1657	0.295466266595136	1012	NA	FT		PLASMA MEMBRANE		Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; TPO2 has a paralog, TPO3, that arose from the whole genome duplication	spermine transport	spermine transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|plasma membrane
YML079W_p	YML079W	YML079W	hom	Uncharacterized	0.413360399795128	0.339671291746255	no	1658	0.342905081592251	1123	NA	FT		NUCLEUS		Non-essential protein of unknown function with structural resemblance to plant storage and ligand binding proteins (canavalin, glycinin, auxin binding protein) and to some enzymes (epimerase, germin); localizes to the nucleus and cytoplasm	biological_process	molecular_function	nucleus|cytoplasm
YPL220W	YPL220W	RPL1A	hom	Verified	0.413101760899958	0.339766029668234	no	1659	0.328603696884368	1129	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L1A; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1A has a paralog, RPL1B, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YHR031C	YHR031C	RRM3	hom	Verified	0.413015818327297	0.339797512173342	no	1660	0.35484984338499	1193	NA	FT	RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION	NUCLEUS|CHROMOSOME		DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p	mitochondrial genome maintenance|replication fork progression beyond termination site|DNA replication	ATP-dependent DNA helicase activity|DNA helicase activity	nuclear telomeric heterochromatin|replication fork
YKR103W	YKR103W	NFT1	hom	Verified	0.412310480584017	0.340055933879029	no	1661	0.344678706641344	1159	NA	FT	NUCLEOTIDE METABOLISM			Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds.	transport	ATPase activity, coupled to transmembrane movement of substances	integral to membrane|membrane
YER056C-A	YER056C-A	RPL34A	hom	Verified	0.412031084514286	0.340158319826044	no	1662	0.299568563846368	1034	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L34A; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34A has a paralog, RPL34B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YPR007C	YPR007C	REC8	hom	Verified	0.411911186242832	0.340202260702063	no	1663	0.345453198854567	1129	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p	synaptonemal complex assembly|protein localization to chromosome, centromeric region|reciprocal meiotic recombination|meiotic sister chromatid cohesion	molecular_function	condensed nuclear chromosome|condensed nuclear chromosome, centromeric region
YMR306W	YMR306W	FKS3	hom	Verified	0.410706995864357	0.340643698255151	no	1664	0.348972202009218	1166	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	MITOCHONDRION|PLASMA MEMBRANE		Protein involved in spore wall assembly, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	ascospore wall assembly	1,3-beta-D-glucan synthase activity	mitochondrion|integral to membrane
YML101C	YML101C	CUE4	hom	Verified	0.410103991635246	0.340864832360652	no	1665	0.279010297739844	932	NA	FT		ENDOPLASMIC RETICULUM		Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; CUE4 has a paralog, CUE1, that arose from the whole genome duplication	biological_process	molecular_function	endoplasmic reticulum|cytoplasm
YKL162C_p	YKL162C	YKL162C	hom	Uncharacterized	0.410048819398724	0.340885067891309	no	1666	0.32178096460846	1073	NA	FT		MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion	biological_process	molecular_function	mitochondrion
YOR228C	YOR228C	YOR228C	hom	Verified	0.409821181287002	0.340968563601153	no	1667	0.3489452248386	1170	NA	FT		MITOCHONDRION		Protein of unknown function, localized to the mitochondrial outer membrane	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion|integral to membrane
YOL075C_p	YOL075C	YOL075C	hom	Uncharacterized	0.409524785537415	0.341077290697586	no	1668	0.312553445190437	1046	NA	FT	NUCLEOTIDE METABOLISM			Putative ABC transporter	transport	ATPase activity, coupled to transmembrane movement of substances	integral to membrane|membrane
YKR005C_p	YKR005C	YKR005C	hom	Uncharacterized	0.40941967894283	0.341115850206486	no	1669	0.333056197865413	1144	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YPL036W	YPL036W	PMA2	hom	Verified	0.409276110563983	0.341168522524673	no	1670	0.322283277874534	1088	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	MITOCHONDRION|PLASMA MEMBRANE		Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential	proton transport|regulation of pH	hydrogen-exporting ATPase activity, phosphorylative mechanism	mitochondrion|integral to membrane|plasma membrane
YDR389W	YDR389W	SAC7	hom	Verified	0.409206685041413	0.341193994447147	no	1671	0.402161500772307	1316	NA	FF|FT	CELL CYCLE|SIGNALING|CYTOSKELETON ORGANIZATION	CYTOSKELETON		GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate	actin filament reorganization involved in cell cycle|small GTPase mediated signal transduction	Rho GTPase activator activity	intracellular
YGL082W_p	YGL082W	YGL082W	hom	Uncharacterized	0.408684685830181	0.34138553685736	no	1672	0.310937155698295	1048	NA	FT		NUCLEUS		Putative protein of unknown function; predicted prenylation/proteolysis target of Afc1p and Rce1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YGL082W is not an essential gene	biological_process	molecular_function	nucleus|plasma membrane|cytoplasm
YLR367W	YLR367W	RPS22B	hom	Verified	0.408621495040248	0.341408726862064	no	1673	0.332585977275969	1122	NA	FT	TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic small ribosomal subunit
YOL155C	YOL155C	HPF1	hom	Verified	0.408065952979873	0.341612627637393	no	1674	0.346652415250365	1172	NA	FT	CELL WALL ORG/BIOGENESIS			Haze-protective mannoprotein that reduces the particle size of aggregated proteins in white wines	fungal-type cell wall organization	glucosidase activity	fungal-type cell wall|extracellular region
YMR289W	YMR289W	ABZ2	hom	Verified	0.407519952013567	0.341813071587269	no	1675	0.351322772860614	1175	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM			Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis	folic acid biosynthetic process	4-amino-4-deoxychorismate lyase activity	cytoplasm
YCL005W	YCL005W	LDB16	hom	Verified	0.405672206505039	0.342491733234605	no	1676	0.369923926735245	1265	NA	FT		MITOCHONDRION		Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria	biological_process	molecular_function	mitochondrion|lipid particle
YFL046W_p	YFL046W	FMP32	hom	Uncharacterized	0.404649570783357	0.342867557769434	no	1677	0.345225090782213	1129	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YJL153C	YJL153C	INO1	hom	Verified	0.403825237927466	0.343170618102051	no	1678	0.356125705401557	1171	NA	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM			Inositol-3-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element	inositol biosynthetic process	inositol-3-phosphate synthase activity	cytoplasm
YOL116W	YOL116W	MSN1	hom	Verified	0.403069383979633	0.343448591313492	no	1679	0.347169180550327	1169	NA	FT	TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM	NUCLEUS		Transcriptional activator; involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress; localizes to the nucleus; relative distribution to the nucleus increases upon DNA replication stress	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription from RNA polymerase II promoter in response to methylglyoxal|positive regulation of transcription from RNA polymerase II promoter in response to increased salt|Unknown|positive regulation of starch catabolic process by positive regulation of transcription from RNA polymerase II promoter|positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding	nucleus
YOR345C_d	YOR345C	YOR345C	hom	Dubious	0.402674271871255	0.34359393165135	no	1680	0.335748179184522	1115	NA					Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2	Unknown	Unknown	Unknown
YBR200W	YBR200W	BEM1	hom	Verified	0.401562997682275	0.344002833144666	no	1681	0.321297801007389	1113	NA	FT		SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein containing SH3-domains, involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p	establishment of cell polarity|cell morphogenesis involved in conjugation with cellular fusion	protein complex scaffold|phosphatidylinositol-3-phosphate binding	incipient cellular bud site|mating projection tip|cellular bud neck|cellular bud tip
YNL092W_p	YNL092W	YNL092W	hom	Uncharacterized	0.401130237267942	0.344162119915174	no	1682	0.33078388823391	1094	NA					Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; YNL092W is not an essential gene	biological_process	S-adenosylmethionine-dependent methyltransferase activity	cellular_component
YJR152W	YJR152W	DAL5	hom	Verified	0.399838690954884	0.344637665610659	no	1683	0.339004371461197	1147	NA	FT		PLASMA MEMBRANE		Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression	dipeptide transport|allantoate transport	dipeptide transporter activity|allantoate transmembrane transporter activity	integral to membrane|plasma membrane
YGR041W	YGR041W	BUD9	hom	Verified	0.399781114602038	0.344658870874178	no	1684	0.32613897936643	1108	NA	FT	CELL CYCLE|CELL DIVISION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Protein involved in bud-site selection; mutant has increased aneuploidy tolerance; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the distal pole	cellular bud site selection	molecular_function	plasma membrane|cellular bud neck
YGL178W	YGL178W	MPT5	hom	Verified	0.399776048582973	0.344660736702928	no	1685	0.328791501866512	1081	NA	FT	TRANSLATION			mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity	negative regulation of translation|negative regulation of translational initiation|Unknown	mRNA binding|protein binding, bridging	cytoplasm
YOR220W	YOR220W	RCN2	hom	Verified	0.399701792906924	0.344688085706182	no	1686	0.338897405540528	1165	NA					Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; phosphorylated in response to alpha factor; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	cytoplasm
YPR093C	YPR093C	ASR1	hom	Verified	0.398864663706013	0.344996463709668	no	1687	0.347509825975107	1168	NA	FT		NUCLEUS		Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain similar to the mammalian rA9 protein	response to ethanol|protein ubiquitination	ubiquitin-protein ligase activity	nucleus|cytoplasm
YOR226C	YOR226C	ISU2	hom	Verified	0.398110837469385	0.345274243058485	no	1688	0.338975660927101	1137	NA	FT	RNA PROCESSING|ION HOMEOSTASIS|ION HOMEOSTASIS|COFACTOR METABOLISM	MITOCHONDRION		Protein required for synthesis of iron-sulfur proteins; localized to the mitochondrial matrix; performs a scaffolding function in mitochondria during Fe/S cluster assembly; involved in Fe-S cluster assembly for both mitochondrial and cytosolic proteins; isu1 isu2 double mutant is inviable; protein abundance increases in response to DNA replication stress; evolutionarily conserved	cellular iron ion homeostasis|iron-sulfur cluster assembly|tRNA wobble uridine modification	molecular_function	mitochondrial matrix
YKR090W	YKR090W	PXL1	hom	Verified	0.397717465545099	0.345419230794836	no	1689	0.349045150572007	1182	NA	FT	SIGNALING	SITE OF POLARIZED GROWTH		Protein that localizes to sites of polarized growth; required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; contains LIM domains and has similarity to metazoan paxillin; relocalizes from bud neck to cytoplasm upon DNA replication stress	maintenance of cell polarity|regulation of Rho protein signal transduction	Rho GDP-dissociation inhibitor activity	incipient cellular bud site|cellular bud|mating projection tip|cellular bud neck|cytoplasm|cellular bud tip
YHR018C	YHR018C	ARG4	hom	Verified	0.397461986746059	0.345513406486426	no	1690	0.342020018060756	1151	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway	arginine biosynthetic process via ornithine	argininosuccinate lyase activity	cytosol
YIL090W	YIL090W	ICE2	hom	Verified	0.396992264254458	0.345686582559672	no	1691	0.353984735782059	1218	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Integral ER membrane protein with type-III transmembrane domains; required for maintenance of ER zinc homeostasis; necessary for efficient targeting of Trm1p tRNA methyltransferase to inner nuclear membrane; mutations cause defects in cortical ER morphology in both the mother and daughter cells	endoplasmic reticulum inheritance	molecular_function	integral to endoplasmic reticulum membrane|integral to membrane|endoplasmic reticulum
YJL110C	YJL110C	GZF3	hom	Verified	0.395757056416877	0.346142129836318	no	1692	0.34158138024945	1122	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		GATA zinc finger protein; negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p; GZF3 has a paralog, DAL80, that arose from the whole genome duplication	maintenance of protein location in nucleus|nitrogen catabolite repression of transcription|negative regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding RNA polymerase II transcription factor activity|sequence-specific DNA binding	nucleus
YNL020C	YNL020C	ARK1	hom	Verified	0.395438054039538	0.346259814805968	no	1693	0.347494251837386	1150	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Serine/threonine protein kinase; involved in regulation of the cortical actin cytoskeleton; involved in control of endocytosis; ARK1 has a paralog, PRK1, that arose from the whole genome duplication	regulation of endocytosis|actin filament organization|protein phosphorylation|cytokinesis|actin cortical patch assembly	protein serine/threonine kinase activity|protein kinase activity	mating projection tip|actin cortical patch
YIR025W	YIR025W	MND2	hom	Verified	0.39499668681003	0.346422666563484	no	1694	0.35454149430125	1165	NA	FT	CELL CYCLE|CELL DIVISION|PROTEOLYSIS|CHROMOSOME SEGREGATION	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Subunit of the anaphase-promoting complex (APC); necessary for maintaining sister chromatid cohesion in prophase I of meiosis by inhibiting premature ubiquitination and subsequent degradation of substrates by the APC(Ama1) ubiquitin ligase	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|reciprocal meiotic recombination|regulation of mitotic metaphase/anaphase transition|protein ubiquitination|mitotic sister chromatid segregation	molecular_function	nucleus|anaphase-promoting complex
YOL073C	YOL073C	YOL073C	hom	Verified	0.394675335628586	0.346541253730121	no	1695	0.34637368512401	1165	NA					Subunit of the DSC ubiquitin ligase complex; ortholog of fission yeast dsc2	biological_process	molecular_function	integral to membrane
YNL253W	YNL253W	TEX1	hom	Verified	0.394571583169442	0.346579544370526	no	1696	0.333503000661737	1123	NA	FT	RNA LOCALIZATION	NUCLEUS		Protein involved in mRNA export, component of the transcription export (TREX) complex	mRNA export from nucleus	molecular_function	transcription export complex
YER143W	YER143W	DDI1	hom	Verified	0.394548446164319	0.346588083473408	no	1697	0.316564838318402	1065	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS	PLASMA MEMBRANE		DNA damage-inducible v-SNARE binding protein with a role in suppression of protein secretion; may play a role in S-phase checkpoint control; has ubiquitin-associated (UBA), ubiquitin-like (UBL), and retroviral-like proteinase (RVP) domains	vesicle-mediated transport|protein secretion|ubiquitin-dependent protein catabolic process	ubiquitin binding|SNARE binding|aspartic-type endopeptidase activity	plasma membrane
YML100W	YML100W	TSL1	hom	Verified	0.393221276573038	0.347078028203721	no	1698	0.318366647972281	1081	NA	FT	CARBOHYDRATE METABOLISM			Large subunit of trehalose 6-phosphate synthase/phosphatase complex; Tps1p-Tps2p complex converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress; TSL1 has a paralog, TPS3, that arose from the whole genome duplication	trehalose biosynthetic process|response to stress	enzyme regulator activity|alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity|trehalose-phosphatase activity	alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
YDR110W	YDR110W	FOB1	hom	Verified	0.39287791491999	0.347204827024745	no	1699	0.343272623953758	1140	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CHROMATIN ORGANIZATION|CHROMOSOME SEGREGATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Nucleolar protein that binds the rDNA replication fork barrier (RFB) site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to RFB and rDNA repeat segregation; related to retroviral integrases	extrachromosomal circular DNA accumulation involved in cell aging|negative regulation of DNA replication|rDNA condensation|chromatin silencing at rDNA|replicative cell aging|protein localization to nucleolar rDNA repeats|DNA recombination	rDNA spacer replication fork barrier binding	nucleolus|rDNA heterochromatin
YOL103W	YOL103W	ITR2	hom	Verified	0.392857733392297	0.347212280322742	no	1700	0.351131678808333	1171	NA	FT		PLASMA MEMBRANE		Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively	myo-inositol transport	myo-inositol transmembrane transporter activity	integral to membrane|plasma membrane|membrane
YNL212W	YNL212W	VID27	hom	Verified	0.392702233534746	0.347269710403656	no	1701	0.345658485425655	1136	NA					Cytoplasmic protein of unknown function; possibly involved in vacuolar protein degradation; not essential for proteasome-dependent degradation of fructose-1,6-bisphosphatase (FBPase); null mutants exhibit normal growth	biological_process	molecular_function	cytoplasm
YMR274C	YMR274C	RCE1	hom	Verified	0.390670568572733	0.348020378133585	no	1702	0.349095536529885	1154	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Type II CAAX prenyl protease involved in the proteolysis and maturation of Ras and the a-factor mating pheromone	CAAX-box protein processing|peptide pheromone maturation|protein processing	metalloendopeptidase activity	integral to endoplasmic reticulum membrane|integral to membrane
YGL251C	YGL251C	HFM1	hom	Verified	0.390457619396605	0.348099094007522	no	1703	0.362096256364263	1222	NA	FT	CELL CYCLE	NUCLEUS		Meiosis specific DNA helicase involved in the conversion of double-stranded breaks to later recombination intermediates and in crossover control; catalyzes the unwinding of Holliday junctions; has ssDNA and dsDNA stimulated ATPase activity	meiosis|synapsis|DNA unwinding involved in replication|reciprocal meiotic recombination	DNA helicase activity	nucleus
YGL009C	YGL009C	LEU1	hom	Verified	0.390089149684264	0.348235312930754	no	1704	0.347676133111544	1161	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway	leucine biosynthetic process	3-isopropylmalate dehydratase activity	cytosol
YPR092W_d	YPR092W	YPR092W	hom	Dubious	0.389921968727344	0.348297124224709	no	1705	0.35349861244523	1180	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YIL010W	YIL010W	DOT5	hom	Verified	0.389602983321749	0.348415072881826	no	1706	0.317716314824316	1060	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS|CHROMOSOME		Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth	cellular response to oxidative stress|cell redox homeostasis	thioredoxin peroxidase activity	nucleus
YPL247C_p	YPL247C	YPL247C	hom	Uncharacterized	0.388670797016897	0.348759843861319	no	1707	0.335424361993176	1118	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; overexpression causes a cell cycle delay or arrest	biological_process	molecular_function	nucleus|cytoplasm
YJR107W_p	YJR107W	YJR107W	hom	Uncharacterized	0.387869168817942	0.34905642758809	no	1708	0.338183441660257	1122	NA	FT	LIPID METABOLISM			Putative lipase	biological_process	lipase activity	cellular_component
YOL024W_p	YOL024W	YOL024W	hom	Uncharacterized	0.387604318041331	0.349154436472662	no	1709	0.343752984344728	1176	NA					Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site; YOL024W has a paralog, IGD1, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YDR253C	YDR253C	MET32	hom	Verified	0.38736096171394	0.349244500137175	no	1710	0.37066731104701	1237	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CELL CYCLE|AMINO ACID METABOLISM	NUCLEUS		Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; MET32 has a paralog, MET31, that arose from the whole genome duplication	regulation of mitotic cell cycle|regulation of sulfur amino acid metabolic process|regulation of transcription from RNA polymerase II promoter	core promoter proximal region sequence-specific DNA binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity	nucleus|cytoplasm
YIL058W_d	YIL058W	YIL058W	hom	Dubious	0.386805511811015	0.349450098210189	no	1711	0.351262891119686	1175	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR267W_p	YLR267W	BOP2	hom	Uncharacterized	0.386026053842355	0.349738686662511	no	1712	0.306582683405702	1019	NA					Protein of unknown function	biological_process	molecular_function	cellular_component
YEL025C_p	YEL025C	YEL025C	hom	Uncharacterized	0.38496705973657	0.350130910389508	no	1713	0.321129671838972	1097	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	biological_process	molecular_function	nucleus|cytoplasm
YGR021W_p	YGR021W	YGR021W	hom	Uncharacterized	0.38282377411351	0.350925216349053	no	1714	0.358808729517317	1205	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YGR249W	YGR249W	MGA1	hom	Verified	0.382079418842175	0.351201228605282	no	1715	0.352286869707716	1205	NA	FT		NUCLEUS		Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants	filamentous growth	sequence-specific DNA binding|DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YBL086C_p	YBL086C	YBL086C	hom	Uncharacterized	0.381143880263241	0.351548244329546	no	1716	0.337812898216993	1137	NA					Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery	biological_process	molecular_function	cellular_component
YPL127C	YPL127C	HHO1	hom	Verified	0.381100671546839	0.351564274564371	no	1717	0.345793779956866	1156	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Histone H1, linker histone with roles in meiosis and sporulation; decreasing levels early in sporulation may promote meiosis, and increasing levels during sporulation facilitate compaction of spore chromatin; binds to promoters and within genes in mature spores; may be recruited by Ume6p to promoter regions, contributing to transcriptional repression outside of meiosis; suppresses DNA repair involving homologous recombination	negative regulation of DNA recombination|negative regulation of chromatin silencing|regulation of transcription, DNA-dependent	DNA binding	nucleus|nuclear nucleosome
YIR027C	YIR027C	DAL1	hom	Verified	0.380772490768846	0.351686036736392	no	1718	0.362510043578662	1217	NA					Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression	allantoin assimilation pathway	allantoinase activity	cellular_component
YPR011C_p	YPR011C	YPR011C	hom	Uncharacterized	0.379383784023993	0.352201445291183	no	1719	0.327405536504134	1103	NA	FT		MITOCHONDRION		Putative transporter, member of the mitochondrial carrier family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	transport	transporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YAL060W	YAL060W	BDH1	hom	Verified	0.378770779259731	0.35242904407725	no	1720	0.357394823198619	1178	NA	FT	OXIDATION-REDUCTION PROCESS			NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source	alcohol metabolic process|butanediol biosynthetic process	(R,R)-butanediol dehydrogenase activity	cytoplasm
YNR071C_p	YNR071C	YNR071C	hom	Uncharacterized	0.377538674528066	0.352886664497526	no	1721	0.351269065021416	1166	NA	FT	CARBOHYDRATE METABOLISM			Putative aldose 1-epimerase	biological_process	molecular_function	cellular_component
YPR091C	YPR091C	NVJ2	hom	Verified	0.375035812645102	0.353816916302195	no	1722	0.33848031238722	1136	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments	biological_process	lipid binding	ribosome|nucleus-vacuole junction|endoplasmic reticulum
YDL224C	YDL224C	WHI4	hom	Verified	0.373515058614892	0.354382569913342	no	1723	0.315159359487248	1047	NA					Putative RNA binding protein; regulates the cell size requirement for passage through Start and commitment to cell division; WHI4 has a paralog, WHI3, that arose from the whole genome duplication	regulation of cell size	RNA binding	cytoplasm
YLR451W	YLR451W	LEU3	hom	Verified	0.373372288209403	0.354435690745008	no	1724	0.353799952265267	1155	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Zinc-knuckle transcription factor, repressor and activator; regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; acts as a repressor in leucine-replete conditions and as an activator in the presence of alpha-isopropylmalate, an intermediate in leucine biosynthesis that accumulates during leucine starvation	negative regulation of transcription from RNA polymerase II promoter|Unknown|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YGL026C	YGL026C	TRP5	hom	Verified	0.373181623944558	0.354506635943599	no	1725	0.422030380078904	1391	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis	tryptophan biosynthetic process	tryptophan synthase activity	nucleus|cytoplasm
YEL066W	YEL066W	HPA3	hom	Verified	0.372610424547408	0.354719206526546	no	1726	0.306424418423064	1073	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro	D-amino acid metabolic process	D-amino-acid N-acetyltransferase activity	nucleus|cytoplasm
YGL219C	YGL219C	MDM34	hom	Verified	0.372374562991968	0.354806995081561	no	1727	0.391395278473661	1280	NA	FT	MITOCHONDRION ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		Mitochondrial component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth	mitochondrion organization|phospholipid transport	molecular_function	mitochondrial outer membrane|ERMES complex|mitochondrion|cytoplasm
YBR178W_d	YBR178W	YBR178W	hom	Dubious	0.369493906121487	0.355879807269296	no	1728	0.361728555971695	1231	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR177C	Unknown	Unknown	Unknown
YGL250W	YGL250W	RMR1	hom	Verified	0.369272716836926	0.355962229754287	no	1729	0.349132009082971	1197	NA	FT	CELL CYCLE	NUCLEUS		Protein required for meiotic recombination and gene conversion; null mutant displays reduced PIS1 expression and growth defects on non-fermentable carbon sources and minimal media; GFP-fusion protein localizes to both cytoplasm and nucleus	meiotic gene conversion|reciprocal meiotic recombination	molecular_function	nucleus|cytoplasm
YLR233C	YLR233C	EST1	hom	Verified	0.369172437325793	0.355999599454038	no	1730	0.288937951679209	953	NA	FT		NUCLEUS|CHROMOSOME		TLC1 RNA-associated factor involved in telomere length regulation as recruitment subunit of telomerase; has G-quadruplex promoting activity that is required for telomere elongation; possible role in activating telomere-bound Est2p-TLC1-RNA	telomere maintenance via telomerase|telomere maintenance|G-quadruplex DNA formation	single-stranded DNA binding|RNA binding|telomeric DNA binding	nucleolus|nucleus|telomerase holoenzyme complex
YLR138W	YLR138W	NHA1	hom	Verified	0.369133286002567	0.356014189780964	no	1731	0.348239354238546	1174	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Na+/H+ antiporter involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH	cellular potassium ion homeostasis|cellular monovalent inorganic cation homeostasis|response to osmotic stress	cation:cation antiporter activity|sodium:hydrogen antiporter activity	membrane raft|integral to membrane|plasma membrane
YCR089W	YCR089W	FIG2	hom	Verified	0.36786077964731	0.356488523024263	no	1732	0.345500419652553	1126	NA	FT	CELL WALL ORG/BIOGENESIS			Cell wall adhesin, expressed specifically during mating; may be involved in maintenance of cell wall integrity during mating	filamentous growth of a population of unicellular organisms|cell morphogenesis involved in conjugation with cellular fusion|invasive growth in response to glucose limitation|cytogamy	molecular_function	fungal-type cell wall|mating projection
YGR122C-A_d	YGR122C-A	YGR122C-A	hom	Dubious	0.367616499461661	0.35657960514083	no	1733	0.35030993419235	1156	NA					Dubious open reading frame unlikely to encode a functional protein, similar to YLR334C and YOL106W	Unknown	Unknown	Unknown
YOL119C	YOL119C	MCH4	hom	Verified	0.367439644333284	0.35664555230889	no	1734	0.334314694641583	1085	NA					Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport	transport	monocarboxylic acid transmembrane transporter activity|transporter activity	fungal-type vacuole membrane|integral to membrane
YOR208W	YOR208W	PTP2	hom	Verified	0.366693522004916	0.356923819584337	no	1735	0.350384035435559	1151	NA	FT	PROTEIN LOCALIZATION|SIGNALING|PROTEIN PHOSPHORYLATION	NUCLEUS		Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the nucleus	inactivation of MAPK activity involved in osmosensory signaling pathway|inactivation of MAPK activity involved in cell wall biogenesis|regulation of sporulation|regulation of protein localization|protein dephosphorylation	protein tyrosine phosphatase activity	nucleus
YDR247W	YDR247W	VHS1	hom	Verified	0.366504498347128	0.356994328292983	no	1736	0.35086971255467	1171	NA	FT	CELL CYCLE|PROTEIN PHOSPHORYLATION			Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p	protein phosphorylation|G1/S transition of mitotic cell cycle	protein serine/threonine kinase activity|protein kinase activity	cytoplasm
YMR178W	YMR178W	YMR178W	hom	Verified	0.366473831003828	0.357005768140594	no	1737	0.340070552981886	1134	NA	FT	COFACTOR METABOLISM	NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; YMR178W is not an essential gene; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YOL151W	YOL151W	GRE2	hom	Verified	0.366331894329575	0.357058716492143	no	1738	0.332259088384439	1118	NA	FT	LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	NUCLEUS		3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase (D-lactaldehyde dehydrogenase); stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress	ergosterol metabolic process|filamentous growth	methylglyoxal reductase (NADPH-dependent) activity|3-methylbutanol:NAD(P) oxidoreductase activity	nucleus|cytoplasm
YDR137W	YDR137W	RGP1	hom	Verified	0.366032598616517	0.357170375408644	no	1739	0.400834767885146	1340	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|CELL DIVISION	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p	retrograde transport, endosome to Golgi	guanyl-nucleotide exchange factor activity	Golgi apparatus|Ric1p-Rgp1p complex|Golgi membrane|guanyl-nucleotide exchange factor complex
YPL145C	YPL145C	KES1	hom	Verified	0.365697914227331	0.357295251345056	no	1740	0.358232280569918	1181	NA	FT	VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication	post-Golgi vesicle-mediated transport|positive regulation of phosphatase activity|maintenance of cell polarity|endocytosis|exocytosis|sterol transport	phosphatidic acid binding|lipid binding|phosphatidylinositol-4,5-bisphosphate binding|oxysterol binding|sterol transporter activity|phosphatidylinositol-4-phosphate binding	Golgi membrane|extrinsic to membrane|cytoplasm
YKL221W	YKL221W	MCH2	hom	Verified	0.36553387452523	0.357356462684613	no	1741	0.370131092353516	1230	NA					Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport	transport	monocarboxylic acid transmembrane transporter activity|transporter activity	integral to membrane|membrane
YOL011W	YOL011W	PLB3	hom	Verified	0.365529479937567	0.357358102573472	no	1742	0.335351083803284	1103	NA	FT	LIPID METABOLISM	PLASMA MEMBRANE		Phospholipase B (lysophospholipase) involved in phospholipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro	phosphatidylinositol metabolic process|phosphatidylserine catabolic process	lysophospholipase activity	extracellular region|plasma membrane
YLR131C	YLR131C	ACE2	hom	Verified	0.364610284123307	0.357701168488139	no	1743	0.489330882144983	1625	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CELL DIVISION	NUCLEUS		Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication	Unknown|regulation of transcription involved in G1 phase of mitotic cell cycle	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding	cytosol|nucleus
YML094C-A_d	YML094C-A	YML094C-A	hom	Dubious	0.364061368388574	0.35790609185721	no	1744	0.346612596563671	1191	NA	FF				Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene GIM5/YML094W; deletion confers sensitivity to GSAO	Unknown	Unknown	Unknown
YBR184W_p	YBR184W	YBR184W	hom	Uncharacterized	0.364000198943666	0.357928930410908	no	1745	0.351929704869178	1200	NA					Putative protein of unknown function; YBR184W is not an essential gene	biological_process	molecular_function	cellular_component
YLR453C	YLR453C	RIF2	hom	Verified	0.363099294643585	0.358265355755193	no	1746	0.354354468363974	1212	NA	FT		NUCLEUS|CHROMOSOME		Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation	telomere capping|telomere maintenance via telomerase	telomeric DNA binding	nuclear telomere cap complex
YAR027W	YAR027W	UIP3	hom	Verified	0.362897015771482	0.358340908040353	no	1747	0.355799593133484	1210	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS|PLASMA MEMBRANE		Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family	biological_process	molecular_function	nuclear envelope
YER130C_p	YER130C	YER130C	hom	Uncharacterized	0.362470800963668	0.358500119796273	no	1748	0.405050744584377	1332	NA	FT		NUCLEUS		Protein of unknown function; transcription is regulated by Haa1p, Sok2p and Zap1p transcriptional activators; computational analysis suggests a role as a transcription factor; C. albicans homolog (MNL1) plays a role in adaptation to stress	biological_process	sequence-specific DNA binding	cellular_component
YER057C	YER057C	HMF1	hom	Verified	0.361490881694813	0.358866260082929	no	1749	0.338476588535873	1124	NA	FT		NUCLEUS		Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro	biological_process	molecular_function	cytosol|nucleus|cytoplasm
YEL060C	YEL060C	PRB1	hom	Verified	0.361442078098717	0.358884498614205	no	1750	0.34459864654973	1128	NA	FT	PROTEOLYSIS|RESPONSE TO NUTRIENT LEVELS			Vacuolar proteinase B (yscB); serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; activity inhibited by Pbi2p; protein abundance increases in response to DNA replication stress	vacuolar protein catabolic process|sporulation resulting in formation of a cellular spore|cellular response to starvation	serine-type endopeptidase activity	fungal-type vacuole lumen|fungal-type vacuole
YKR070W_p	YKR070W	YKR070W	hom	Uncharacterized	0.361231249727339	0.358963291583405	no	1751	0.349094962084799	1139	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YDR453C	YDR453C	TSA2	hom	Verified	0.361192262759269	0.358977862855689	no	1752	0.349668103558304	1147	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS			Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants; protein abundance increases in response to DNA replication stress	cellular response to oxidative stress|cell redox homeostasis	peroxiredoxin activity|thioredoxin peroxidase activity	cytoplasm
YGL157W	YGL157W	ARI1	hom	Verified	0.361097589579423	0.359013247550828	no	1753	0.3562831924892	1219	NA	FT	OXIDATION-REDUCTION PROCESS	NUCLEUS		NADPH-dependent aldehyde reductase, utilizes aromatic and alophatic aldehyde substrates; member of the short-chain dehydrogenase/reductase superfamily	biological_process	oxidoreductase activity|carbonyl reductase (NADPH) activity	nucleus|cytoplasm
YPL152W	YPL152W	RRD2	hom	Verified	0.360588999610279	0.359203356941355	no	1754	0.339498597955007	1130	NA	FT	CELL CYCLE|CYTOSKELETON ORGANIZATION			Peptidyl-prolyl cis/trans-isomerase; also activates the phosphotyrosyl phosphatase activity of protein phosphatase 2A (PP2A); regulates G1 phase progression, the osmoresponse, microtubule dynamics; subunit of the Tap42p-Pph21p-Rrd2p complex; protein abundance increases in response to DNA replication stress	mitotic spindle organization in nucleus|response to osmotic stress	peptidyl-prolyl cis-trans isomerase activity|protein phosphatase type 2A regulator activity	protein phosphatase type 2A complex
YPL181W	YPL181W	CTI6	hom	Verified	0.35939813602762	0.35964863447263	no	1755	0.362482803050963	1209	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain	negative regulation of chromatin silencing at silent mating-type cassette|positive regulation of transcription, DNA-dependent|regulation of DNA-dependent DNA replication initiation|negative regulation of chromatin silencing at telomere|negative regulation of chromatin silencing at rDNA	methylated histone residue binding|transcription factor binding	Rpd3L-Expanded complex|nucleus|Rpd3L complex
YKL011C	YKL011C	CCE1	hom	Verified	0.359313482719311	0.359680294577211	no	1756	0.366550982611863	1213	NA	FT	MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial cruciform cutting endonuclease, cleaves Holliday junctions formed during recombination of mitochondrial DNA	mitochondrial genome maintenance	endodeoxyribonuclease activity	mitochondrial inner membrane
YNL097C-B_p	YNL097C-B	YNL097C-B	hom	Uncharacterized	0.358845593222499	0.359855301328446	no	1757	0.34013293228228	1118	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YPR149W	YPR149W	NCE102	hom	Verified	0.356584281727875	0.360701523148648	no	1758	0.351112025170104	1198	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION	ENDOPLASMIC RETICULUM|MITOCHONDRION|PLASMA MEMBRANE		Protein of unknown function; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs)	eisosome assembly|protein secretion|negative regulation of protein phosphorylation|plasma membrane organization|establishment of protein localization to plasma membrane	molecular_function	mitochondrion|integral to membrane|membrane raft|endoplasmic reticulum|cellular bud membrane|plasma membrane|mating projection membrane|cytoplasm
YML022W	YML022W	APT1	hom	Verified	0.353876408882921	0.36171575375254	no	1759	0.320226915352253	1090	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		Adenine phosphoribosyltransferase; catalyzes the formation of AMP from adenine and 5-phosphoribosylpyrophosphate; involved in the salvage pathway of purine nucleotide biosynthesis; APT1 has a paralog, APT2, that arose from the whole genome duplication	AMP biosynthetic process|adenine salvage	adenine phosphoribosyltransferase activity	nucleus|cytoplasm
YMR010W_p	YMR010W	YMR010W	hom	Uncharacterized	0.353783856666183	0.361750436298966	no	1760	0.361225872604025	1170	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR010W is not an essential gene; YMR010W mRNA is transcribed with ADI1	biological_process	molecular_function	integral to membrane|cytoplasm
YER142C	YER142C	MAG1	hom	Verified	0.353716221476082	0.361775782283914	no	1761	0.343691204249279	1150	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		3-methyl-adenine DNA glycosylase; involved in protecting DNA against alkylating agents; initiates base excision repair by removing damaged bases to create abasic sites that are subsequently repaired; protein abundance increases in response to DNA replication stress	base-excision repair, AP site formation|DNA dealkylation involved in DNA repair	alkylbase DNA N-glycosylase activity	nucleus
YJR121W	YJR121W	ATP2	hom	Verified	0.353601437990718	0.361818798269319	no	1762	0.358616991440643	1195	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	MITOCHONDRION		Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated	ATP synthesis coupled proton transport	hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism	proton-transporting ATP synthase complex, catalytic core F(1)|mitochondrion|mitochondrial proton-transporting ATP synthase, catalytic core|integral to membrane
YOL076W	YOL076W	MDM20	hom	Verified	0.353191876805325	0.361972298668716	no	1763	0.402122143985888	1350	NA	FF|FT	MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION			Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly	mitochondrion inheritance|N-terminal peptidyl-methionine acetylation|cytoskeleton organization	peptide alpha-N-acetyltransferase activity	NatB complex
YDR169C	YDR169C	STB3	hom	Verified	0.352944898890275	0.362064874836502	no	1764	0.351044271949106	1169	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress	positive regulation of transcription from RNA polymerase II promoter by glucose	sequence-specific DNA binding	nucleus|cytoplasm
YGL131C	YGL131C	SNT2	hom	Verified	0.352503196013854	0.362230461013062	no	1765	0.357231737609327	1181	NA	FT		NUCLEUS|CHROMOSOME		DNA binding protein with similarity to the S. pombe Snt2 protein; RING finger ubiquitin ligase (E3) involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p; null mutant sensitive to hydroxyurea (HU); computational analysis suggests that Snt2p is a transcription factor with a role in regulation of expression of genes encoding amine transporters; relocalizes from nucleus to cytoplasm upon DNA replication stress	biological_process	DNA binding	nucleus|Snt2C complex|cytoplasm
YMR055C	YMR055C	BUB2	hom	Verified	0.352442636718352	0.362253165574854	no	1766	0.356774449372573	1218	NA	FT	CELL CYCLE|SIGNALING|CELL DIVISION|NUCLEOTIDE METABOLISM	CYTOSKELETON		Mitotic exit network regulator, forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anaphase in response to spindle and kinetochore damage	regulation of exit from mitosis|mitotic cell cycle spindle orientation checkpoint	GTPase activator activity	spindle pole body
YLR231C	YLR231C	BNA5	hom	Verified	0.352261065077757	0.362321242331447	no	1767	0.330055079696733	1095	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	NUCLEUS		Kynureninase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p	de novo NAD biosynthetic process from tryptophan	kynureninase activity	nucleus|cytoplasm
YOL019W_p	YOL019W	YOL019W	hom	Uncharacterized	0.351888599235474	0.36246090478329	no	1768	0.364867035987347	1195	NA	FT		PLASMA MEMBRANE		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole; YOL019W has a paralog, DCV1, that arose from the whole genome duplication	biological_process	molecular_function	integral to membrane|plasma membrane|fungal-type vacuole
YPR058W	YPR058W	YMC1	hom	Verified	0.351721634097594	0.362523517166984	no	1769	0.358727730332564	1151	NA	FT		MITOCHONDRION		Putative mitochondrial inner membrane transporter; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; YMC1 has a paralog, YMC2, that arose from the whole genome duplication	mitochondrial transport	organic acid transmembrane transporter activity	mitochondrion|integral to membrane
YNL094W	YNL094W	APP1	hom	Verified	0.349405343773479	0.3633925110425	no	1770	0.391927468002096	1291	NA	FT	CYTOSKELETON ORGANIZATION	CYTOSKELETON		Phosphatidate phosphatase, converts phosphatidate to diacylglycerol; App1p, Pah1p, Dpp1p, and Lpp1p are responsible for all the phosphatidate phosphatase activity; component of cortical actin patches; interacts with components of endocytic pathway	actin cytoskeleton organization	molecular_function	actin cytoskeleton|actin cortical patch
YLR035C	YLR035C	MLH2	hom	Verified	0.348765053982974	0.363632850441124	no	1771	0.376841710532461	1246	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS		Protein involved in the mismatch repair of certain frameshift intermediates and involved in meiotic recombination; forms a complex with Mlh1p	mismatch repair|reciprocal meiotic recombination	molecular_function	nucleus
YNL303W_d	YNL303W	YNL303W	hom	Dubious	0.348747969163341	0.363639264140583	no	1772	0.355690844319868	1207	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YIL119C	YIL119C	RPI1	hom	Verified	0.348370765363199	0.363780877464268	no	1773	0.345194956654934	1156	NA	FT	SIGNALING	NUCLEUS		Transcription factor with allelic differences between S288C and Sigma1278b; mediates fermentation stress tolerance by modulating cell wall integrity; overexpression suppresses heat shock sensitivity of wild-type RAS2 overexpression and also suppresses cell lysis defect of mpk1 mutation; allele from S288c can confer fMAPK pathway independent transcription of FLO11; S288C and Sigma1278b alleles differ in number of tandem repeats within ORF	fungal-type cell wall biogenesis|Ras protein signal transduction|positive regulation of transcription from RNA polymerase II promoter	small GTPase regulator activity	nucleus
YCL014W	YCL014W	BUD3	hom	Verified	0.34833468454417	0.363794424233035	no	1774	0.364138381410726	1228	NA	FT	CELL CYCLE|SIGNALING|CELL DIVISION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding	cellular bud site selection|axial cellular bud site selection|cytokinesis	molecular_function	cellular bud neck contractile ring|cellular bud neck
YKR102W	YKR102W	FLO10	hom	Verified	0.347333177511824	0.364170514198705	no	1775	0.354366961782229	1180	NA					Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth	filamentous growth of a population of unicellular organisms|flocculation via cell wall protein-carbohydrate interaction|flocculation|invasive growth in response to glucose limitation	mannose binding	fungal-type cell wall
YBL078C	YBL078C	ATG8	hom	Verified	0.346078333912884	0.364641922778022	no	1776	0.406970772119327	1360	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS	ENDOMEMBRANE SYSTEM		Component of autophagosomes and Cvt vesicles; unique ubiquitin-like protein whose &#65532;conjugation target is the lipid phosphatidylethanolamine (PE); Atg8p-PE is anchored to membranes, is involved in phagophore expansion, and may mediate membrane fusion during autophagosome formation; deconjugation of Atg8p-PE is required for efficient autophagosome biogenesis	piecemeal microautophagy of nucleus|mitochondrion degradation|cellular membrane fusion|ER to Golgi vesicle-mediated transport|CVT pathway|autophagic vacuole assembly	molecular_function	cytosol|fungal-type vacuole membrane|pre-autophagosomal structure|extrinsic to membrane|autophagic vacuole
YGR001C_p	YGR001C	YGR001C	hom	Uncharacterized	0.345972426001862	0.364681718707681	no	1777	0.340652017211302	1143	NA					Putative protein of unknown function with similarity to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiae	biological_process	methyltransferase activity	cytoplasm
YGR203W	YGR203W	YCH1	hom	Verified	0.345884455709409	0.364714775511024	no	1778	0.367421632281003	1201	NA	FT		NUCLEUS		Phosphatase with sequence similarity to Cdc25p, Arr2p and Mih1p; member of the single-domain rhodanese homology superfamily; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	dephosphorylation	phosphatase activity|protein tyrosine phosphatase activity|thiosulfate sulfurtransferase activity	nucleus|cytoplasm
YCR088W	YCR088W	ABP1	hom	Verified	0.345478595977255	0.364867299397239	no	1779	0.357678148561953	1164	NA	FT	PROTEIN LOCALIZATION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization; phosphorylation within its PRR (Proline-Rich Region), mediated by Cdc28p and Pho85p, protects Abp1p from proteolysis mediated by its own PEST sequences	protein localization|actin cortical patch assembly	actin filament binding	cell cortex|mating projection tip|cytoplasm|actin cortical patch
YKR058W	YKR058W	GLG1	hom	Verified	0.344621060676728	0.3651896352725	no	1780	0.359491119214238	1222	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG1 has a paralog, GLG2, that arose from the whole genome duplication	glycogen biosynthetic process	glycogenin glucosyltransferase activity	cellular_component
YJR077C	YJR077C	MIR1	hom	Verified	0.344617044862497	0.365191144986826	no	1781	0.356428720187451	1192	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated	phosphate ion transmembrane transport	inorganic phosphate transmembrane transporter activity	mitochondrion|integral to membrane|integral to mitochondrial inner membrane
YPR184W	YPR184W	GDB1	hom	Verified	0.343814757997069	0.36549280040944	no	1782	0.372217825688279	1253	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS|MITOCHONDRION		Glycogen debranching enzyme; contains glucanotranferase and alpha-1,6-amyloglucosidase activities; required for glycogen degradation; phosphorylated in mitochondria; activity is inhibited by Igd1p; protein abundance increases in response to DNA replication stress	glycogen catabolic process	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity	mitochondrion|cytoplasm
YGL067W	YGL067W	NPY1	hom	Verified	0.343626890314944	0.365563449649988	no	1783	0.327915572653401	1078	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes; nudix hydrolase family member	NADH metabolic process	NAD+ diphosphatase activity	peroxisome|cytoplasm
YGR032W	YGR032W	GSC2	hom	Verified	0.343593349957081	0.365576063266872	no	1784	0.354306223312955	1214	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	PLASMA MEMBRANE|CYTOSKELETON		Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)	ascospore wall assembly|(1->3)-beta-D-glucan biosynthetic process	1,3-beta-D-glucan synthase activity	1,3-beta-D-glucan synthase complex|integral to membrane|actin cap|prospore membrane
YLR013W	YLR013W	GAT3	hom	Verified	0.343063855223379	0.365775211096424	no	1785	0.363211111314271	1194	NA	FT		NUCLEUS		Protein containing GATA family zinc finger motifs	transcription, DNA-dependent	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YOL099C_d	YOL099C	YOL099C	hom	Dubious	0.343017421988436	0.365792676788431	no	1786	0.329324235690672	1109	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PKH2/YOL100W; may interact with ribosomes	Unknown	Unknown	Unknown
YKL131W_d	YKL131W	YKL131W	hom	Dubious	0.341075638997498	0.366523320038795	no	1787	0.341270270034038	1189	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR204C	YMR204C	INP1	hom	Verified	0.341071553110487	0.366524857964727	no	1788	0.353099234048331	1157	NA	FT	PEROXISOME ORGANIZATION			Peripheral membrane protein of peroxisomes involved in peroxisomal inheritance; recruitment to peroxisomes is mediated by interaction with Pex3p at the peroxisomal membrane	peroxisome inheritance	molecular_function	peroxisome|extrinsic to intraperoxisomal membrane
YDL128W	YDL128W	VCX1	hom	Verified	0.34052807280491	0.366729442787195	no	1789	0.346624036938754	1144	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Vacuolar membrane antiporter with Ca2+/H+ and K+/H+ exchange activity, involved in control of cytosolic Ca2+ and K+ concentrations; has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter	manganese ion transport|cellular calcium ion homeostasis|calcium ion transport|transmembrane transport	potassium:hydrogen antiporter activity|calcium:hydrogen antiporter activity	fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YLR271W_p	YLR271W	YLR271W	hom	Uncharacterized	0.340476039892534	0.366749031765764	no	1790	0.347924179835322	1139	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	nucleus|cytoplasm
YDL187C_d	YDL187C	YDL187C	hom	Dubious	0.340281331155144	0.366822337396832	no	1791	0.384070356018729	1251	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YNR032W	YNR032W	PPG1	hom	Verified	0.340096118378274	0.36689207241405	no	1792	0.372757411210755	1249	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Putative serine/threonine protein phosphatase of the type 2A-like phosphatase family, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases	glycogen metabolic process|protein dephosphorylation	protein serine/threonine phosphatase activity	nucleus|cytoplasm
YJL020C	YJL020C	BBC1	hom	Verified	0.338907828517709	0.367339583396987	no	1793	0.347049363414822	1155	NA	FT	CYTOSKELETON ORGANIZATION	CYTOSKELETON		Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches	actin cytoskeleton organization	myosin I binding	actin cortical patch
YLL046C	YLL046C	RNP1	hom	Verified	0.338876041824427	0.367351556770936	no	1794	0.346248048472259	1145	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS			Ribonucleoprotein that contains two RNA recognition motifs (RRM)	ribosome biogenesis	RNA binding	cytoplasm
YNR025C_d	YNR025C	YNR025C	hom	Dubious	0.33873498001705	0.367404693321365	no	1795	0.372396064278015	1245	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion reduces expression of PIS1 gene encoding phosphatidylinositol synthase	Unknown	Unknown	Unknown
YKL077W_p	YKL077W	YKL077W	hom	Uncharacterized	0.337338789338594	0.367930760957511	no	1796	0.3737649826964	1233	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole	biological_process	molecular_function	fungal-type vacuole
YDL173W	YDL173W	PAR32	hom	Verified	0.335340513642828	0.368684117848409	no	1797	0.385196344731353	1294	NA					Putative protein of unknown function; hyperphosphorylated upon rapamycin treatment in a Tap42p-dependent manner; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; PAR32 is not an essential gene	biological_process	molecular_function	cytoplasm
YJL122W	YJL122W	ALB1	hom	Verified	0.335045237158388	0.368795480998597	no	1798	0.345156572577742	1169	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS	NUCLEUS		Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p	ribosomal large subunit biogenesis	molecular_function	ribosome|nucleus|cytoplasm
YGR033C	YGR033C	TIM21	hom	Verified	0.334422283129769	0.369030463449201	no	1799	0.363599612317963	1198	NA	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Nonessential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); interacts with the Translocase of the Outer Mitochondrial membrane (TOM complex) and with respiratory enzymes; may regulate TIM23 complex activity	protein import into mitochondrial matrix	molecular_function	mitochondrion|mitochondrial inner membrane presequence translocase complex
YLL063C	YLL063C	AYT1	hom	Verified	0.334118367572591	0.369145120215957	no	1800	0.337770251720161	1151	NA					Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis	secondary metabolic process	trichothecene 3-O-acetyltransferase activity	cellular_component
YER177W	YER177W	BMH1	hom	Verified	0.334017051651835	0.369183345776364	no	1801	0.359655605611765	1222	NA	FT	CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress	glycogen metabolic process|pseudohyphal growth|signal transduction involved in filamentous growth|ascospore formation|fungal-type cell wall chitin biosynthetic process|Ras protein signal transduction|DNA damage checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	DNA replication origin binding|phosphoserine binding	plasma membrane|nucleus
YLR404W	YLR404W	FLD1	hom	Verified	0.333018764129979	0.369560059545234	no	1802	0.370508488165183	1218	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Seipin protein involved in lipid droplet morphology, number, and size; proposed to be involved in lipid metabolism; related to the human BSCL2 which is associated with lipodystrophy	lipid particle organization	molecular_function	integral to membrane|endoplasmic reticulum|cortical endoplasmic reticulum
YPL166W	YPL166W	ATG29	hom	Verified	0.332013095374329	0.369939685346958	no	1803	0.366821742511892	1226	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|RESPONSE TO NUTRIENT LEVELS			Autophagy-specific protein; required for recruiting other ATG proteins to the pre-autophagosomal structure (PAS); interacts with Atg17p and localizas to the PAS in a manner interdependent with Atg17p and Cis1p; not conserved; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress	mitochondrion degradation|piecemeal microautophagy of nucleus|macroautophagy	molecular_function	pre-autophagosomal structure|cytoplasm
YNL270C	YNL270C	ALP1	hom	Verified	0.331153227598525	0.370264373882697	no	1804	0.363369393759049	1215	NA	FT		PLASMA MEMBRANE		Arginine transporter; expression is normally very low and it is unclear what conditions would induce significant expression; ALP1 has a paralog, CAN1, that arose from the whole genome duplication	basic amino acid transport	basic amino acid transmembrane transporter activity	integral to membrane|plasma membrane
YHR161C	YHR161C	YAP1801	hom	Verified	0.330879310983178	0.370367825011454	no	1805	0.371088778260849	1225	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON		Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1801 has a paralog, YAP1802, that arose from the whole genome duplication	endocytosis	clathrin binding	actin cortical patch
YOL112W	YOL112W	MSB4	hom	Verified	0.330170977299383	0.370635387542564	no	1806	0.372295284810254	1270	NA	FT	SIGNALING|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH		GTPase-activating protein of the Ras superfamily that acts primarily on Sec4p, localizes to the bud site and bud tip, has similarity to Msb3p; msb3 msb4 double mutation causes defects in secretion and actin organization	actin filament organization	Rab GTPase activator activity	incipient cellular bud site|polarisome|cellular bud tip
YEL005C	YEL005C	VAB2	hom	Verified	0.329790779805396	0.370779027318586	no	1807	0.370333787741337	1227	NA					Protein with a potential role in vacuolar function, as suggested by its ability to bind Vac8p; likely member of BLOC complex involved in endosomal cargo sorting; Vab2p-GFP-fusion localizes to cytoplasm in punctate patter	biological_process	molecular_function	cytoplasm
YHR050W-A_p	YHR050W-A	YHR050W-A	hom	Uncharacterized	0.329590037163605	0.370854875769391	no	1808	0.374207454750217	1251	NA					Protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YPL216W_p	YPL216W	YPL216W	hom	Uncharacterized	0.329398438304963	0.370927274020824	no	1809	0.373116773052962	1255	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS		Putative protein of unknown function; YPL216W is not an essential gene	biological_process	molecular_function	cellular_component
YNL058C_p	YNL058C	YNL058C	hom	Uncharacterized	0.327725915765552	0.371559453335163	no	1810	0.351345104827484	1185	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL058C is not an essential gene	biological_process	molecular_function	fungal-type vacuole
YOL159C-A	YOL159C-A	YOL159C-A	hom	Verified	0.327450270509733	0.371663674916099	no	1811	0.352503062496602	1154	NA	FT		NUCLEUS		Protein of unknown function; overexpression affects endocytic protein trafficking; identified by sequence comparison with hemiascomycetous yeast species	biological_process	molecular_function	nucleus|cytoplasm
YPL230W	YPL230W	USV1	hom	Verified	0.326893092128716	0.371874373003317	no	1812	0.344650293444042	1150	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in growth on non-fermentable carbon sources, response to salt stress and cell wall biosynthesis; USV1 has a paralog, RGM1, that arose from the whole genome duplication	carbon catabolite activation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter in response to salt stress	sequence-specific DNA binding	nucleus
YLR329W	YLR329W	REC102	hom	Verified	0.325604164266835	0.372361930564753	no	1813	0.3852965776347	1257	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Protein involved in early stages of meiotic recombination; required for chromosome synapsis; forms a complex with Rec104p and Spo11p necessary during the initiation of recombination	meiotic DNA double-strand break formation|reciprocal meiotic recombination	molecular_function	condensed nuclear chromosome|nucleus
YGL234W	YGL234W	ADE5,7	hom	Verified	0.323657330452981	0.373098739352072	no	1814	0.37180181900743	1226	NA	FT	NUCLEOTIDE METABOLISM			Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities	purine nucleobase metabolic process|purine nucleotide biosynthetic process|'de novo' IMP biosynthetic process	phosphoribosylamine-glycine ligase activity|phosphoribosylformylglycinamidine cyclo-ligase activity	cytoplasm
YDL034W_d	YDL034W	YDL034W	hom	Dubious	0.322720335543084	0.373453524990979	no	1815	0.368867987008995	1225	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps with verified gene GPR1/YDL035C; YDL034W is not an essential gene	Unknown	Unknown	Unknown
YOL085C_d	YOL085C	YOL085C	hom	Dubious	0.321396115070952	0.373955113406218	no	1816	0.375518760566248	1250	NA					Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A	Unknown	Unknown	Unknown
YJR092W	YJR092W	BUD4	hom	Verified	0.320796982620745	0.374182123083799	no	1817	0.370095211626517	1217	NA	FT	CELL CYCLE|CELL DIVISION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Anillin-like protein involved in bud-site selection; required for the axial budding pattern; localizes with septins to the bud neck in mitosis and may constitute an axial landmark for the next round of budding; required for the formation and disassembly of the double septin ring structure, and generally for septin organization; in vivo substrate of Cdc28p/Clb2p	cellular bud site selection|axial cellular bud site selection	GTP binding	cellular bud neck contractile ring
YLR353W	YLR353W	BUD8	hom	Verified	0.320404384617248	0.374330901083257	no	1818	0.341508197242769	1122	NA	FT	CELL CYCLE|CELL DIVISION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole	pseudohyphal growth|cellular bud site selection	molecular_function	incipient cellular bud site|plasma membrane|cellular bud tip
YMR165C	YMR165C	PAH1	hom	Verified	0.320402386959922	0.37433165815857	no	1819	0.369872193515231	1223	NA	FT	LIPID METABOLISM|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Mg2+-dependent phosphatidate (PA) phosphatase; dephosphorylates PA to yield diacylglycerol; responsible for de novo lipid synthesis and formation of lipid droplets; phosphorylation by Pho80p-Pho85p decreases catalytic activity and alters Pah1p localization and abundance; phosphorylation by protein kinase A decreases catalytic efficiency; dephosphorylation by Nem1p-Spo7p anchors Pah1p to the membrane increasing substrate catalysis; homologous to mammalian lipins 1 and 2	plasmid maintenance|vacuole fusion, non-autophagic|lipid particle organization|aerobic respiration|phospholipid biosynthetic process	phosphatidate phosphatase activity	cytosol|nuclear membrane|vacuole|cytoplasm|extrinsic to membrane
YOR037W	YOR037W	CYC2	hom	Verified	0.31958242198068	0.374642450663657	no	1820	0.345194105035836	1146	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)	cytochrome c-heme linkage|mitochondrial membrane organization	oxidoreductase activity	extrinsic to mitochondrial inner membrane|mitochondrion
YDR121W	YDR121W	DPB4	hom	Verified	0.319202445857028	0.374786501190116	no	1821	0.373365446609127	1256	NA	FT	GENE SILENCING	NUCLEUS|CHROMOSOME		Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization	DNA-dependent DNA replication|chromatin silencing at telomere	double-stranded DNA binding|single-stranded DNA binding|DNA-directed DNA polymerase activity	chromatin accessibility complex|epsilon DNA polymerase complex
YGR169C	YGR169C	PUS6	hom	Verified	0.318841138694684	0.374923490442323	no	1822	0.339601032928227	1113	NA	FT	RNA PROCESSING	MITOCHONDRION		tRNA:pseudouridine synthase, catalyzes the conversion of uridine to pseudouridine at position 31 in cytoplasmic and mitochondrial tRNAs; mutation of Asp168 to Ala abolishes enzyme activity; not essential for viability	tRNA pseudouridine synthesis	pseudouridine synthase activity	mitochondrion|cytoplasm
YER089C	YER089C	PTC2	hom	Verified	0.31824227983773	0.375150581933774	no	1823	0.349854952902535	1176	NA	FT	CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION	NUCLEUS		Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; inactivates the DNA damage checkpoint; PTC2 has a paralog, PTC3, that arose from the whole genome duplication	endoplasmic reticulum unfolded protein response|inactivation of MAPK activity involved in osmosensory signaling pathway|regulation of cyclin-dependent protein kinase activity|protein dephosphorylation|DNA damage checkpoint	protein serine/threonine phosphatase activity	nucleus|cytoplasm
YPR138C	YPR138C	MEP3	hom	Verified	0.317985838030568	0.375247839711245	no	1824	0.371598062886471	1211	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Ammonium permease of high capacity and low affinity; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation ammonia permease	nitrogen utilization|ammonium transport	ammonium transmembrane transporter activity	integral to membrane|plasma membrane
YIL008W	YIL008W	URM1	hom	Verified	0.316465177426105	0.375824726186056	no	1825	0.380369948740026	1258	NA	FT	RNA PROCESSING|CELL DIVISION|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs; receives sulfur from the E1-like enzyme Uba4p and transfers it to tRNA; also functions as a protein tag with roles in nutrient sensing and oxidative stress response	cellular response to oxidative stress|tRNA wobble position uridine thiolation|cell budding|protein urmylation|invasive growth in response to glucose limitation|tRNA wobble uridine modification	protein tag	cytosol|nucleus|cytoplasm
YKL031W_d	YKL031W	YKL031W	hom	Dubious	0.315989171969362	0.376005363451693	no	1826	0.379467463347817	1222	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species	Unknown	Unknown	Unknown
YBL102W	YBL102W	SFT2	hom	Verified	0.315540974739933	0.37617547273071	no	1827	0.39189668301729	1310	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Non-essential tetra-spanning membrane protein found mostly in the late Golgi, can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to mammalian syntaxin 5	Golgi to endosome transport	molecular_function	integral to membrane|Golgi membrane
YHR045W_p	YHR045W	YHR045W	hom	Uncharacterized	0.315103448270588	0.376341555224657	no	1828	0.373785521619436	1234	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOPLASMIC RETICULUM		Putative protein of unknown function; possible role in iron metabolism and/or amino acid and carbohydrate metabolism; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum	biological_process	molecular_function	endoplasmic reticulum
YLR041W_d	YLR041W	YLR041W	hom	Dubious	0.31482443101612	0.376447480505317	no	1829	0.364664319544112	1214	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YLR040C	Unknown	Unknown	Unknown
YKR015C_p	YKR015C	YKR015C	hom	Uncharacterized	0.314367689116898	0.37662089672132	no	1830	0.364138611084699	1203	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YPR145W	YPR145W	ASN1	hom	Verified	0.312557206573581	0.377308547195949	no	1831	0.386160580126116	1271	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN1 has a paralog, ASN2, that arose from the whole genome duplication	asparagine biosynthetic process	asparagine synthase (glutamine-hydrolyzing) activity	cytoplasm
YML086C	YML086C	ALO1	hom	Verified	0.312254960982281	0.377423382916015	no	1832	0.36388499931809	1216	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		D-Arabinono-1,4-lactone oxidase, catalyzes the final step in biosynthesis of dehydro-D-arabinono-1,4-lactone, which is protective against oxidative stress	cellular response to oxidative stress|dehydro-D-arabinono-1,4-lactone biosynthetic process	D-arabinono-1,4-lactone oxidase activity	mitochondrial outer membrane|mitochondrion|integral to mitochondrial outer membrane
YDR216W	YDR216W	ADR1	hom	Verified	0.311790699863257	0.377599796206883	no	1833	0.393248293992241	1283	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|CHROMATIN ORGANIZATION|OXIDATION-REDUCTION PROCESS|RESPONSE TO NUTRIENT LEVELS|GENE SILENCING|PEROXISOME ORGANIZATION	NUCLEUS		Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization	negative regulation of chromatin silencing|positive regulation of transcription from RNA polymerase II promoter in response to ethanol|chromatin organization|regulation of transcription by chromatin organization|positive regulation of fatty acid beta-oxidation by positive regulation of transcription from RNA polymerase II promoter|positive regulation of peroxisome organization by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter by oleic acid|cellular response to oleic acid|peroxisome organization|positive regulation of ethanol catabolic process by positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|TFIIB-class transcription factor binding|sequence-specific DNA binding|TFIID-class transcription factor binding|RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription	nucleus
YDL211C_p	YDL211C	YDL211C	hom	Uncharacterized	0.311024907543397	0.377890843287955	no	1834	0.37688767882378	1259	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole	biological_process	molecular_function	fungal-type vacuole
YDL050C_d	YDL050C	YDL050C	hom	Dubious	0.310151590800505	0.378222840715005	no	1835	0.368142631999767	1234	NA					Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YER030W	YER030W	CHZ1	hom	Verified	0.308968043004036	0.378672918123899	no	1836	0.357575243520321	1208	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS		Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif; protein abundance increases in response to DNA replication stress	chromatin remodeling	histone binding	chromatin assembly complex|nucleus
YPR040W	YPR040W	TIP41	hom	Verified	0.308769852768377	0.378748301653242	no	1837	0.388969287860244	1287	NA	FT	SIGNALING	NUCLEUS		Protein that interacts with Tap42p, which regulates PP2A; component of the TOR (target of rapamycin) signaling pathway; protein abundance increases in response to DNA replication stress	signal transduction	molecular_function	nucleus|cytoplasm
YOL006C	YOL006C	TOP1	hom	Verified	0.307936071797355	0.379065488622725	no	1838	0.367524686810661	1198	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|CHROMOSOME SEGREGATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination	nuclear migration|chromatin assembly or disassembly|DNA topological change|DNA strand elongation involved in DNA replication|regulation of mitotic recombination|chromatin silencing at rDNA|regulation of transcription from RNA polymerase II promoter|mitotic chromosome condensation|transcription elongation from RNA polymerase II promoter	DNA topoisomerase type I activity	replication fork protection complex|nucleolus|nucleus
YOR311C	YOR311C	DGK1	hom	Verified	0.307211007363717	0.379341383863354	no	1839	0.363816327168854	1211	NA	FT	VESICLE-MEDIATED TRANSPORT|KETONE METABOLISM|LIPID METABOLISM	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Diacylglycerol kinase, localized to the endoplasmic reticulum (ER); overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation; contains a CTP transferase domain	phosphatidic acid biosynthetic process	diacylglycerol kinase activity	integral to endoplasmic reticulum membrane|integral to membrane
YJL171C	YJL171C	YJL171C	hom	Verified	0.3051660809765	0.380119832232365	no	1840	0.34673711101911	1178	NA	FT		MITOCHONDRION|PLASMA MEMBRANE		GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	mitochondrion|fungal-type cell wall|plasma membrane
YDR524C	YDR524C	AGE1	hom	Verified	0.304982711808423	0.380189659717671	no	1841	0.322309187269041	1091	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM	GOLGI APPARATUS		ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif	ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport	phospholipid binding|ARF GTPase activator activity	endosome|trans-Golgi network|cytoplasm
YIL066C	YIL066C	RNR3	hom	Verified	0.304735402408166	0.380283842004641	no	1842	0.382379548198542	1268	NA	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM	MITOCHONDRION		Minor isoform of the large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits	deoxyribonucleotide biosynthetic process	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	mitochondrion|ribonucleoside-diphosphate reductase complex|cytoplasm
YKL096W	YKL096W	CWP1	hom	Verified	0.304196848508914	0.380488962836276	no	1843	0.371495834347274	1241	NA	FT	MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS			Cell wall mannoprotein that localizes specifically to birth scars of daughter cells, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; required for propionic acid resistance	fungal-type cell wall organization|ascospore-type prospore membrane assembly	structural constituent of cell wall	fungal-type cell wall|cellular birth scar|prospore membrane
YMR036C	YMR036C	MIH1	hom	Verified	0.304014729137611	0.380558334859211	no	1844	0.36355732651493	1210	NA	FT	CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION	NUCLEUS		Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25	G2/M transition of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity	protein tyrosine phosphatase activity	nucleus|cytoplasm
YBR071W	YBR071W	YBR071W	hom	Verified	0.30268471909682	0.381065072118477	no	1845	0.382848047143233	1253	NA	FT		SITE OF POLARIZED GROWTH		Protein of unknown function found in the cytoplasm and bud neck; mRNA expression may be regulated by the cell cycle and/or cell wall stress; overexpression of YBR071W affects endocytic protein trafficking	biological_process	molecular_function	cellular bud neck|cytoplasm
YOR113W	YOR113W	AZF1	hom	Verified	0.302609764949401	0.381093635923248	no	1846	0.401715414398409	1342	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL WALL ORG/BIOGENESIS	NUCLEUS		Zinc-finger transcription factor; in the presence of glucose, activates transcription of genes involved in growth and carbon metabolism; in nonfermentable carbon sources, activates transcription of genes involved in maintenance of cell wall integrity	regulation of fungal-type cell wall organization|regulation of transcription from RNA polymerase II promoter|cellular response to carbohydrate stimulus	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YMR062C	YMR062C	ARG7	hom	Verified	0.301156149140014	0.381647713174626	no	1847	0.427385513135682	1414	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS	MITOCHONDRION		Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine	fungal-type cell wall organization|ornithine biosynthetic process|arginine biosynthetic process	acetyl-CoA:L-glutamate N-acetyltransferase activity|glutamate N-acetyltransferase activity	mitochondrion|mitochondrial matrix
YER034W	YER034W	YER034W	hom	Verified	0.30084381287451	0.381766798630299	no	1848	0.390829160123939	1284	NA	FT		NUCLEUS		Protein of unknown function; non-essential gene; expression induced upon calcium shortage; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YKL094W	YKL094W	YJU3	hom	Verified	0.300297868487221	0.381974979476772	no	1849	0.379842158921181	1276	NA	FT	LIPID METABOLISM	ENDOPLASMIC RETICULUM|MITOCHONDRION		Monoglyceride lipase (MGL), functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family	triglyceride metabolic process	serine hydrolase activity|acylglycerol lipase activity	mitochondrial outer membrane|lipid particle|plasma membrane|membrane|cytoplasm
YDR508C	YDR508C	GNP1	hom	Verified	0.299711560462538	0.382198589894313	no	1850	0.352622242188678	1169	NA	FT		MITOCHONDRION|PLASMA MEMBRANE		High-affinity glutamine permease; also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids; GNP1 has a paralog, AGP1, that arose from the whole genome duplication	amino acid transport|transmembrane transport	amino acid transmembrane transporter activity|L-proline transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YAR031W	YAR031W	PRM9	hom	Verified	0.298367646676477	0.382711289663075	no	1851	0.380636526592728	1272	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Pheromone-regulated protein with 3 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; member of DUP240 gene family	vesicle organization	molecular_function	integral to membrane|endoplasmic reticulum|plasma membrane
YOR229W	YOR229W	WTM2	hom	Verified	0.298147864626814	0.382795155554512	no	1852	0.380679647325207	1259	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS		Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; involved in response to replication stress; contains WD repeats	negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of transcription from RNA polymerase II promoter during meiosis|cellular protein complex localization|negative regulation of chromatin silencing at telomere|response to DNA damage stimulus|positive regulation of transcription from RNA polymerase II promoter	protein binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|transcription corepressor activity	nucleus
YEL071W	YEL071W	DLD3	hom	Verified	0.297138005364027	0.38318057492908	no	1853	0.379234601013855	1253	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS			D-lactate dehydrogenase, part of the retrograde regulon which consists of genes whose expression is stimulated by damage to mitochondria and reduced in cells grown with glutamate as the sole nitrogen source, located in the cytoplasm	lactate metabolic process|filamentous growth	D-lactate dehydrogenase (cytochrome) activity	cytoplasm
YLR169W_d	YLR169W	YLR169W	hom	Dubious	0.296742146540069	0.383331688608744	no	1854	0.366103008187676	1204	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOL138C	YOL138C	RTC1	hom	Verified	0.294937323191399	0.384020879829865	no	1855	0.385737754981076	1294	NA					Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; null mutation suppresses cdc13-1 temperature sensitivity; has N-terminal WD-40 repeats and a C-terminal RING motif	biological_process	molecular_function	ribosome|fungal-type vacuole|Seh1-associated complex|extrinsic to fungal-type vacuolar membrane
YER144C	YER144C	UBP5	hom	Verified	0.293065608435142	0.384736001841747	no	1856	0.389158992122493	1293	NA	FT	PROTEOLYSIS	SITE OF POLARIZED GROWTH		Putative ubiquitin-specific protease, closest paralog of Doa4p but has no functional overlap; concentrates at the bud neck	protein deubiquitination	ubiquitin-specific protease activity	incipient cellular bud site|cellular bud neck
YJL037W	YJL037W	IRC18	hom	Verified	0.291920521373431	0.385173696381761	no	1857	0.390702922170357	1302	NA					Putative protein of unknown function; expression induced in respiratory-deficient cells and in carbon-limited chemostat cultures; similar to adjacent ORF, YJL038C; null mutant displays increased levels of spontaneous Rad52p foci	biological_process	molecular_function	cellular_component
YDL062W_d	YDL062W	YDL062W	hom	Dubious	0.291843319692176	0.385203210985224	no	1858	0.391272863152659	1300	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YDL063C; YDL062W is not essential	Unknown	Unknown	Unknown
YOR352W	YOR352W	TFB6	hom	Verified	0.290954114260163	0.385543206736562	no	1859	0.384567483549554	1262	NA	FT		NUCLEUS		Subunit of TFIIH complex; facilities dissociation of the Ssl2p helices from TFIIH; expression levels regulated by Arg5,6p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus	biological_process	molecular_function	nucleus|holo TFIIH complex|cytoplasm
YGL230C_p	YGL230C	YGL230C	hom	Uncharacterized	0.28959330990154	0.386063692859272	no	1860	0.378546048538961	1263	NA					Putative protein of unknown function; non-essential gene	biological_process	molecular_function	cellular_component
YOR231W	YOR231W	MKK1	hom	Verified	0.288695042802611	0.386407378264845	no	1861	0.389456261150927	1298	NA	FT	SIGNALING|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION	SITE OF POLARIZED GROWTH		MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication	signal transduction|peroxisome degradation|protein phosphorylation	protein kinase activity|MAP kinase kinase activity	cellular bud tip
YOL082W	YOL082W	ATG19	hom	Verified	0.288580580473823	0.386451179032157	no	1862	0.366421741738904	1209	NA	FT	PROTEIN LOCALIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT			Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; delivers cargo proteins aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p) to the phagophore assembly site for packaging into Cvt vesicles	vesicle organization|ER-associated protein catabolic process|protein processing|protein complex localization|CVT pathway	protein binding, bridging	pre-autophagosomal structure|cytoplasm|CVT complex|extrinsic to membrane
YPR077C_d	YPR077C	YPR077C	hom	Dubious	0.287822733810331	0.386741217169245	no	1863	0.392497476497985	1300	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression increased by deletion of NAP1	Unknown	Unknown	Unknown
YOL124C	YOL124C	TRM11	hom	Verified	0.28777136096663	0.386760880540868	no	1864	0.392956042891363	1283	NA	FT	RNA PROCESSING			Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain	tRNA methylation	S-adenosylmethionine-dependent methyltransferase activity|RNA binding|tRNA (guanine-N2-)-methyltransferase activity	cytoplasm|tRNA (m2G10) methyltransferase complex
YDR482C	YDR482C	CWC21	hom	Verified	0.28692397687543	0.387085265566924	no	1865	0.396997900858492	1322	NA	FT	RNA PROCESSING	NUCLEUS		Protein involved in RNA splicing by the spliceosome; component of a complex containing Cef1p; interacts genetically with ISY1 and BUD13; may bind RNA; has similarity to S. pombe Cwf21p	mRNA splicing, via spliceosome	molecular_function	U2-type spliceosomal complex
YJL209W	YJL209W	CBP1	hom	Verified	0.286872963391286	0.38710479643307	no	1866	0.376366603869493	1222	NA	FT	RNA PROCESSING|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Mitochondrial protein, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex at the inner membrane along with Pet309p; localizes to mitochondrial foci upon DNA replication stress	mitochondrial mRNA catabolic process|aerobic respiration	mRNA binding	mitochondrion|extrinsic to mitochondrial inner membrane
YMR272W-B_p	YMR272W-B	YMR272W-B	hom	Uncharacterized	0.286550258099582	0.387228353012733	no	1867	0.350453352958295	1187	NA					Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YDL051W	YDL051W	LHP1	hom	Verified	0.286296729220289	0.387325431519015	no	1868	0.388771581453263	1272	NA	FT	RNA PROCESSING	NUCLEUS		RNA binding protein required for maturation of tRNA and U6 snRNA precursors; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen	tRNA processing	RNA binding|tRNA binding	nucleoplasm|nucleolus|nucleus
YBR299W	YBR299W	MAL32	hom	Verified	0.285709723160339	0.387550228496884	no	1869	0.387592828755069	1301	NA	FT	CARBOHYDRATE METABOLISM			Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose	sucrose catabolic process|maltose catabolic process	sucrose alpha-glucosidase activity|alpha-glucosidase activity|maltose alpha-glucosidase activity	plasma membrane
YJL055W_p	YJL055W	YJL055W	hom	Uncharacterized	0.284864243245676	0.387874075606503	no	1870	0.390443800065632	1293	NA	FT		NUCLEUS		Putative protein of unknown function, proposed to be involved in the metabolism of purine and pyrimidine base analogues; deletion mutants are sensitive to HAP and AHA; overexpression confers resistance to 5-FOA and 5-FU	response to chemical stimulus|response to purine-containing compound	molecular_function	nucleus|cytoplasm
YHL032C	YHL032C	GUT1	hom	Verified	0.284504848052216	0.388011759635787	no	1871	0.367811829440526	1247	NA	FT	CARBOHYDRATE METABOLISM	MITOCHONDRION		Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p	glycerol metabolic process	glycerol kinase activity	mitochondrion|cytoplasm
YBR090C_p	YBR090C	YBR090C	hom	Uncharacterized	0.284324511737004	0.388080851648643	no	1872	0.38057144781047	1267	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus	biological_process	molecular_function	nucleus|cytoplasm
YDR107C	YDR107C	TMN2	hom	Verified	0.284211594183636	0.388124115404596	no	1873	0.366424596268299	1204	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT			Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments	cellular copper ion homeostasis|pseudohyphal growth|vacuolar transport|invasive growth in response to glucose limitation	molecular_function	fungal-type vacuole membrane|integral to membrane
YMR157C	YMR157C	AIM36	hom	Verified	0.28419495237302	0.388130491742633	no	1874	0.369004084540197	1216	NA	FT		MITOCHONDRION		Protein of unknown function; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YDR488C	YDR488C	PAC11	hom	Verified	0.283446842143648	0.388417162573594	no	1875	0.354871415975962	1201	NA	FT		CYTOSKELETON		Dynein intermediate chain, acts in the cytoplasmic dynein pathway, forms cortical cytoplasmic microtubule capture site with Num1p; null mutant is defective in nuclear migration, essential in the absence of CIN8	nuclear migration along microtubule|microtubule-based process	plus-end-directed microtubule motor activity|microtubule motor activity	cytoplasmic dynein complex|cytoplasmic microtubule
YDR059C	YDR059C	UBC5	hom	Verified	0.282420803640868	0.388810432497142	no	1876	0.390998724268996	1284	NA					Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived, abnormal, or excess proteins, including histone H3; central component of the cellular stress response; expression is heat inducible; protein abundance increases in response to DNA replication stress; UBC5 has a paralog, UBC4, that arose from the whole genome duplication	protein polyubiquitination|response to stress	ubiquitin-protein ligase activity	proteasome complex
YDR034C	YDR034C	LYS14	hom	Verified	0.281880738831033	0.389017479550289	no	1877	0.398212595795498	1315	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer	Unknown|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YHR184W	YHR184W	SSP1	hom	Verified	0.28184417526308	0.389031498228214	no	1878	0.391446626258837	1318	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION			Protein involved in the control of meiotic nuclear division and coordination of meiosis with spore formation; transcription is induced midway through meiosis	ascospore wall assembly|protein complex assembly	molecular_function	prospore membrane
YOR215C	YOR215C	AIM41	hom	Verified	0.281673918860661	0.389096777394269	no	1879	0.389329271807973	1286	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss	biological_process	molecular_function	mitochondrion
YGL004C	YGL004C	RPN14	hom	Verified	0.281114361862917	0.389311342994217	no	1880	0.407611323140994	1350	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS	NUCLEUS		Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p	proteasome regulatory particle assembly|ubiquitin-dependent protein catabolic process	molecular_function	cytosol|nucleus|cytoplasm
YDR532C	YDR532C	KRE28	hom	Verified	0.280895922329003	0.389395114151544	no	1881	0.407390124175148	1327	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME|CYTOSKELETON	KINETOCHORE	Subunit of a kinetochore-microtubule binding complex with Spc105p that bridges centromeric heterochromatin and kinetochore MAPs and motors, and is also required for sister chromatid bi-orientation and kinetochore binding of SAC components	biological_process	molecular_function	chromosome, centromeric region|condensed nuclear chromosome kinetochore|spindle pole body
YJL052W	YJL052W	TDH1	hom	Verified	0.280492313418582	0.38954991094274	no	1882	0.39703050509443	1302	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress	gluconeogenesis|glycolysis	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity	mitochondrion|fungal-type cell wall|lipid particle|plasma membrane|cytoplasm
YGL262W_p	YGL262W	YGL262W	hom	Uncharacterized	0.278955256147971	0.390139581310649	no	1883	0.368575731814963	1230	NA					Putative protein of unknown function; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein; YGL262W is not an essential gene	biological_process	molecular_function	cellular_component
YDR131C_p	YDR131C	YDR131C	hom	Uncharacterized	0.278558937075215	0.390291664600058	no	1884	0.375001904503093	1243	NA	FT	PROTEOLYSIS			F-box protein, substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity|protein binding, bridging	SCF ubiquitin ligase complex
YDR084C	YDR084C	TVP23	hom	Verified	0.278457129922969	0.39033073473893	no	1885	0.358384484045227	1218	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	vesicle-mediated transport	molecular_function	integral to membrane|integral to Golgi membrane|cytoplasm
YER170W	YER170W	ADK2	hom	Verified	0.278453655587591	0.390332068090789	no	1886	0.387121797538425	1294	NA	FT	NUCLEOTIDE METABOLISM	MITOCHONDRION		Mitochondrial adenylate kinase, catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background	nucleotide metabolic process	nucleoside triphosphate adenylate kinase activity|adenylate kinase activity	mitochondrion|mitochondrial inner membrane
YHL016C	YHL016C	DUR3	hom	Verified	0.277502257153045	0.390697236447483	no	1887	0.373883718823	1230	NA	FT		PLASMA MEMBRANE		Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway	urea transport|spermidine transport|putrescine transport|urea catabolic process	urea transmembrane transporter activity|spermidine transmembrane transporter activity|putrescine transmembrane transporter activity	integral to membrane|plasma membrane
YOR162C	YOR162C	YRR1	hom	Verified	0.277476051341731	0.390707296199797	no	1888	0.440549278296079	1466	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication	regulation of transcription from RNA polymerase II promoter in response to oxidative stress|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity	nucleus
YPR045C	YPR045C	THP3	hom	Verified	0.275989502983307	0.391278064324266	no	1889	0.371857434699073	1271	NA	FT	RNA PROCESSING	NUCLEUS|CHROMOSOME		Protein that forms a complex with Csn12p that is recruited to transcribed genes and may have a role in transcription elongation; possibly involved in splicing based on pre-mRNA accumulation defect for many intron-containing genes	mRNA splicing, via spliceosome	molecular_function	nucleus|transcriptionally active chromatin
YNL332W	YNL332W	THI12	hom	Verified	0.275837170359967	0.391336566492808	no	1890	0.374964967069546	1228	NA					Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13	thiamine biosynthetic process	molecular_function	cellular_component
YBR230C	YBR230C	OM14	hom	Verified	0.275623271987432	0.391418716661269	no	1891	0.399938525377795	1329	NA	FT		MITOCHONDRION		Integral mitochondrial outer membrane protein; abundance is decreased in cells grown in glucose relative to other carbon sources; appears to contain 3 alpha-helical transmembrane segments; ORF encodes a 97-basepair intron	biological_process	molecular_function	mitochondrion|integral to mitochondrial outer membrane
YOL039W	YOL039W	RPP2A	hom	Verified	0.275559302492786	0.391443285833885	no	1892	0.398585295933833	1326	NA	FT	TRANSLATION		RIBOSOME	Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm	translational elongation|cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YDR163W	YDR163W	CWC15	hom	Verified	0.274623281042	0.39180283905828	no	1893	0.402268668592805	1303	NA	FT	RNA PROCESSING	NUCLEUS		Non-essential protein involved in pre-mRNA splicing, component of a complex containing Cef1p; has similarity to S. pombe Cwf15p	mRNA splicing, via spliceosome	molecular_function	U2-type spliceosomal complex
YFR030W	YFR030W	MET10	hom	Verified	0.274020844291617	0.392034301549866	no	1894	0.389909341030711	1319	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY			Subunit alpha of assimilatory sulfite reductase, which converts sulfite into sulfide	sulfate assimilation	sulfite reductase (NADPH) activity	sulfite reductase complex (NADPH)
YPL167C	YPL167C	REV3	hom	Verified	0.273748266987919	0.392139041157861	no	1895	0.3903324645141	1275	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION|CHROMOSOME		Catalytic subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair	error-prone translesion synthesis|error-free translesion synthesis	DNA-directed DNA polymerase activity	nuclear chromatin|mitochondrion|zeta DNA polymerase complex
YHR079C-A	YHR079C-A	SAE3	hom	Verified	0.273200134317295	0.392349688367799	no	1896	0.388006569341341	1287	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Mei5p; proposed to be an assembly factor for Dmc1p	double-strand break repair|reciprocal meiotic recombination|meiotic DNA recombinase assembly	molecular_function	condensed nuclear chromosome
YDR315C	YDR315C	IPK1	hom	Verified	0.272195036784368	0.392736028944971	no	1897	0.430692211901749	1426	NA	FT		NUCLEUS		Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable	nuclear-transcribed mRNA catabolic process, non-stop decay|inositol phosphate biosynthetic process	inositol pentakisphosphate 2-kinase activity	nucleus
YJR147W	YJR147W	HMS2	hom	Verified	0.272110988585439	0.39276834028543	no	1898	0.386714821258033	1263	NA	FT		NUCLEUS		Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant; HMS2 has a paralog, SKN7, that arose from the whole genome duplication	pseudohyphal growth	molecular_function	nucleus|cytoplasm
YML053C_p	YML053C	YML053C	hom	Uncharacterized	0.271443341210696	0.39302503569056	no	1899	0.389542746309537	1281	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene	biological_process	molecular_function	nucleus|cytoplasm
YNL277W-A_p	YNL277W-A	YNL277W-A	hom	Uncharacterized	0.271347589122483	0.393061854032895	no	1900	0.376049822855955	1270	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YFL019C_d	YFL019C	YFL019C	hom	Dubious	0.271167400774154	0.393131142178653	no	1901	0.383637192509014	1264	NA					Dubious open reading frame unlikely to encode a protein; YFL019C is not an essential gene	Unknown	Unknown	Unknown
YBR276C	YBR276C	PPS1	hom	Verified	0.271127073171425	0.393146649887115	no	1902	0.353160046047361	1187	NA	FT	CELL CYCLE|SIGNALING|PROTEIN PHOSPHORYLATION	NUCLEUS		Protein phosphatase with specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle	inactivation of MAPK activity|protein dephosphorylation|regulation of S phase of mitotic cell cycle	protein tyrosine/serine/threonine phosphatase activity	cellular_component
YDR521W_d	YDR521W	YDR521W	hom	Dubious	0.270823212747925	0.393263502820197	no	1903	0.377116314486592	1247	NA					Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol	Unknown	Unknown	Unknown
YBR214W	YBR214W	SDS24	hom	Verified	0.269577340153941	0.39374271753543	no	1904	0.392805492836169	1297	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL DIVISION			Protein involved in cell separation during budding; one of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; may play an indirect role in fluid-phase endocytosis; protein abundance increases in response to DNA replication stress; SDS24 has a paralog, SDS23, that arose from the whole genome duplication	endocytosis|cytokinetic cell separation	molecular_function	cytoplasm
YBR261C	YBR261C	TAE1	hom	Verified	0.269293211931033	0.393852027701884	no	1905	0.378135813973774	1264	NA	FT	TRANSLATION			AdoMet-dependent proline methyltransferase; catalyzes the dimethylation of ribosomal proteins Rpl12 and Rps25 at N-terminal proline residues; has a role in protein synthesis; fusion protein localizes to the cytoplasm	cytoplasmic translation|N-terminal peptidyl-proline dimethylation	N-terminal protein N-methyltransferase activity	cytosol|cytoplasm
YMR147W_p	YMR147W	YMR147W	hom	Uncharacterized	0.268187497218888	0.39427749918822	no	1906	0.378835340830505	1231	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YNL146C-A_p	YNL146C-A	YNL146C-A	hom	Uncharacterized	0.267999700173269	0.394349774760917	no	1907	0.382089603015591	1267	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YGL002W	YGL002W	ERP6	hom	Verified	0.266800936153679	0.39481121671409	no	1908	0.415366553713739	1366	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication	ER to Golgi vesicle-mediated transport	molecular_function	mitochondrion|integral to membrane
YGL140C_p	YGL140C	YGL140C	hom	Uncharacterized	0.266773552536971	0.394821759255706	no	1909	0.360974158518755	1211	NA					Putative protein of unknown function; non-essential gene; contains multiple predicted transmembrane domains	biological_process	molecular_function	integral to membrane
YDR261C	YDR261C	EXG2	hom	Verified	0.265825222579859	0.395186908532612	no	1910	0.390012836555056	1300	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	PLASMA MEMBRANE		Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor	fungal-type cell wall organization	glucan exo-1,3-beta-glucosidase activity	fungal-type cell wall
YJL201W	YJL201W	ECM25	hom	Verified	0.26575353363043	0.395214515718117	no	1911	0.422658253721234	1402	NA	FT	SIGNALING|CELL WALL ORG/BIOGENESIS			Non-essential protein of unknown function; promoter contains a consensus binding sequence for factor Abf1p	fungal-type cell wall organization|filamentous growth	molecular_function	cytoplasm
YDL204W	YDL204W	RTN2	hom	Verified	0.265112420486806	0.395461429711405	no	1912	0.398438062848111	1311	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Reticulon protein; stabilizes membrane curvature; involved in nuclear pore assembly and maintenance of tubular ER morphology; interacts with exocyst subunit Sec6p, Yip3p, and Sbh1p; much less abundant than Rtn1p; rtn1 rtn2 yop1 triple mutant lacks tubular ER; member of RTNLA (reticulon-like A) subfamily; protein increases in abundance and relocalizes to plasma membrane upon DNA replication stress; RTN2 has a paralog, RTN1, that arose from the whole genome duplication	endoplasmic reticulum tubular network organization|endoplasmic reticulum tubular network maintenance	molecular_function	endoplasmic reticulum|cortical endoplasmic reticulum|endoplasmic reticulum tubular network
YGR250C	YGR250C	YGR250C	hom	Verified	0.264868869965287	0.395555240122754	no	1913	0.397526471931018	1318	NA					Putative RNA binding protein; localizes to stress granules induced by glucose deprivation; interacts with Rbg1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress	biological_process	RNA binding	cytoplasmic stress granule|cytoplasm
YNL063W	YNL063W	MTQ1	hom	Verified	0.264502125897377	0.395696513448909	no	1914	0.405987681598834	1335	NA	FT	TRANSLATION	MITOCHONDRION		S-adenosylmethionine-dependent methyltransferase; methylates translational release factor Mrf1p; similar to E.coli PrmC; is not an essential gene	translational readthrough	S-adenosylmethionine-dependent methyltransferase activity	mitochondrion
YIR019C	YIR019C	FLO11	hom	Verified	0.263827549098917	0.395956402664798	no	1915	0.385901009443607	1247	NA	FT		SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		GPI-anchored cell surface glycoprotein (flocculin); required for pseudohyphal formation, invasive growth, flocculation, and biofilms; transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p); required for the formation of fibrous interconnections between cells in a colony of a wild S. cerevisiae strain	cell-cell adhesion|biofilm formation|pseudohyphal growth|filamentous growth|flocculation|invasive growth in response to glucose limitation	molecular_function	extracellular region|plasma membrane|cellular bud neck
YFL028C	YFL028C	CAF16	hom	Verified	0.263169939000587	0.396209799773026	no	1916	0.388676455649994	1260	NA	FT	TRANSCRIPTION FROM RNA POL II|NUCLEOTIDE METABOLISM	NUCLEUS		Part of evolutionarily-conserved CCR4-NOT regulatory complex; contains single ABC-type ATPase domain but no transmembrane domain; interacts with several subunits of Mediator	regulation of transcription from RNA polymerase II promoter	ATPase activity	CCR4-NOT complex|cytoplasm
YJR148W	YJR148W	BAT2	hom	Verified	0.262025672389891	0.396650824881137	no	1917	0.389917893471965	1297	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Cytosolic branched-chain amino acid (BCAA) aminotransferase, preferentially involved in BCAA catabolism; homolog of murine ECA39; highly expressed during stationary phase and repressed during logarithmic phase	branched-chain amino acid catabolic process|branched-chain amino acid biosynthetic process	branched-chain-amino-acid transaminase activity	nucleus|cytoplasm
YGL224C	YGL224C	SDT1	hom	Verified	0.26193755818813	0.396684791491826	no	1918	0.397667615272092	1300	NA					Pyrimidine nucleotidase; overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II, as well as resistance to other pyrimidine derivatives	pyrimidine nucleobase metabolic process	nucleotidase activity	cellular_component
YAL051W	YAL051W	OAF1	hom	Verified	0.260968604133624	0.39705835938698	no	1919	0.394912462538154	1283	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GENE SILENCING	NUCLEUS		Oleate-activated transcription factor; acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis; OAF1 has a paralog, PIP2, that arose from the whole genome duplication	cellular response to oleic acid|positive regulation of fatty acid beta-oxidation|positive regulation of chromatin silencing at telomere|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YMR082C_d	YMR082C	YMR082C	hom	Dubious	0.260210457976314	0.397350718878198	no	1920	0.411080255044654	1351	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGL248W	YGL248W	PDE1	hom	Verified	0.258059517107996	0.39818048713626	no	1921	0.390639890044065	1286	NA	FT	SIGNALING|NUCLEOTIDE METABOLISM			Low-affinity cyclic AMP phosphodiesterase, controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation	cAMP-mediated signaling	3',5'-cyclic-AMP phosphodiesterase activity	cellular_component
YLR290C_p	YLR290C	YLR290C	hom	Uncharacterized	0.257863886996431	0.398255978256438	no	1922	0.377365058942507	1275	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR290C is not an essential gene	biological_process	molecular_function	mitochondrion
YNL089C_d	YNL089C	YNL089C	hom	Dubious	0.25706929728644	0.398562639228724	no	1923	0.407652678572252	1324	NA					Dubious open reading frame unlikely to encode a functional protein; almost completely overlaps YNL090W/RHO2 which encodes a small GTPase of the Rho/Rac subfamily of Ras-like proteins	Unknown	Unknown	Unknown
YDR516C	YDR516C	EMI2	hom	Verified	0.256923842922678	0.398618782129149	no	1924	0.381541237253521	1226	NA	FT	TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression regulated by glucose-repression transcription factors Mig1/2p; EMI2 has a paralog, GLK1, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	ascospore formation|positive regulation of transcription from RNA polymerase II promoter	molecular_function	cytoplasm
YIL044C	YIL044C	AGE2	hom	Verified	0.256729228495741	0.398693903255888	no	1925	0.400478000002119	1315	NA	FT	VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM	GOLGI APPARATUS		ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in Trans-Golgi-Network (TGN) transport; contains C2C2H2 cysteine/histidine motif	ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport	ARF GTPase activator activity	clathrin-coated vesicle
YIL092W_p	YIL092W	YIL092W	hom	Uncharacterized	0.2563037917506	0.398858134814818	no	1926	0.400271137980383	1321	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus	biological_process	molecular_function	nucleus|cytoplasm
YCR009C	YCR009C	RVS161	hom	Verified	0.255941565553647	0.398997979290702	no	1927	0.403828531215095	1309	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION|RESPONSE TO NUTRIENT LEVELS	SITE OF POLARIZED GROWTH|CYTOSKELETON		Amphiphysin-like lipid raft protein; interacts with Rvs167p and regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress	conjugation with cellular fusion|actin cytoskeleton reorganization|endocytosis|actin cortical patch localization|response to starvation|response to osmotic stress|lipid tube assembly|actin cytoskeleton organization	cytoskeletal protein binding|lipid binding	membrane raft|mating projection tip|mating projection|actin cortical patch
YIL074C	YIL074C	SER33	hom	Verified	0.253858570387137	0.39980241125686	no	1928	0.380531468027595	1294	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS			3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER33 has a paralog, SER3, that arose from the whole genome duplication	serine family amino acid biosynthetic process	phosphoglycerate dehydrogenase activity	cytoplasm
YJL051W	YJL051W	IRC8	hom	Verified	0.253825145000092	0.399815323285438	no	1929	0.391397369765379	1283	NA					Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52p foc	mitotic recombination	molecular_function	integral to membrane|cellular bud
YBR137W	YBR137W	YBR137W	hom	Verified	0.25356083106776	0.399917430045409	no	1930	0.388005568810864	1279	NA					Protein of unknown function; localized to the cytoplasm; binds to Replication Protein A (RPA); also interacts with Sgt2p; YBR137W is not an essential gene	biological_process	molecular_function	TRC complex|cytoplasm
YNL042W-B_p	YNL042W-B	YNL042W-B	hom	Uncharacterized	0.252630500381383	0.400276879232802	no	1931	0.390963226669644	1306	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YGR003W	YGR003W	CUL3	hom	Verified	0.250516632295936	0.401093921989104	no	1932	0.396490423252514	1287	NA	FT	PROTEOLYSIS	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Ubiquitin-protein ligase, forms a complex with Elc1p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; cullin family member with similarity to Cdc53p and human CUL3	protein ubiquitination involved in ubiquitin-dependent protein catabolic process|ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity	nucleus|Cul3-RING ubiquitin ligase complex|cytoplasm
YER004W	YER004W	FMP52	hom	Verified	0.249542957662833	0.401470408107396	no	1933	0.411619609743744	1352	NA	FT		ENDOPLASMIC RETICULUM|MITOCHONDRION		Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion|endoplasmic reticulum
YLR134W	YLR134W	PDC5	hom	Verified	0.249451972435875	0.401505593609515	no	1934	0.400894098890148	1309	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Minor isoform of pyruvate decarboxylase, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde, regulation is glucose- and ethanol-dependent, repressed by thiamine, involved in amino acid catabolism	L-phenylalanine catabolic process|glucose catabolic process to ethanol|pyruvate metabolic process|tryptophan catabolic process|aromatic amino acid family catabolic process to alcohol via Ehrlich pathway	pyruvate decarboxylase activity	nucleus|cytoplasm
YGR176W_d	YGR176W	YGR176W	hom	Dubious	0.249268977241183	0.401576363316116	no	1935	0.394217855051661	1313	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGR241C	YGR241C	YAP1802	hom	Verified	0.248949446611701	0.401699943091149	no	1936	0.409543003702452	1371	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON		Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1802 has a paralog, YAP1801, that arose from the whole genome duplication	endocytosis	clathrin binding	actin cortical patch
YBR173C	YBR173C	UMP1	hom	Verified	0.248457920780451	0.40189006190074	no	1937	0.396974249271674	1318	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE|PROTEOLYSIS	NUCLEUS		Short-lived chaperone required for correct maturation of the 20S proteasome; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its assembly	proteasome assembly|response to DNA damage stimulus|ubiquitin-dependent protein catabolic process	molecular_function	nucleus|cytoplasm
YKR076W	YKR076W	ECM4	hom	Verified	0.24826051234163	0.401966424664421	no	1938	0.406461570587461	1338	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS			Omega class glutathione transferase; not essential; similar to Ygr154cp; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	fungal-type cell wall organization|glutathione metabolic process	glutathione transferase activity	cytoplasm
YLR016C	YLR016C	PML1	hom	Verified	0.248081823860784	0.402035549284276	no	1939	0.376932305251555	1234	NA	FT	RNA PROCESSING|RNA LOCALIZATION	NUCLEUS		Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p	mRNA export from nucleus|mRNA splicing, via spliceosome|maintenance of RNA location	molecular_function	RES complex|nucleus|cytoplasm
YFL042C_p	YFL042C	YFL042C	hom	Uncharacterized	0.247910554828082	0.402101806609059	no	1940	0.406427703513302	1339	NA					Putative protein of unknown function; YFL042C is not an essential gene	biological_process	molecular_function	cellular_component
YBL104C	YBL104C	SEA4	hom	Verified	0.247775360851382	0.402154109885271	no	1941	0.48927881431854	1720	NA					Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; has an N-terminal beta-propeller fold and a C-terminal RING motif; promoter contains multiple GCN4 binding sites	biological_process	molecular_function	Seh1-associated complex|extrinsic to fungal-type vacuolar membrane|cytoplasm
YDL079C	YDL079C	MRK1	hom	Verified	0.247726390290105	0.402173055842043	no	1942	0.400545783282211	1315	NA	FT	PROTEIN PHOSPHORYLATION			Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation	regulation of protein catabolic process|protein phosphorylation|response to stress	protein serine/threonine kinase activity	cellular_component
YPL150W_p	YPL150W	YPL150W	hom	Uncharacterized	0.245778637774949	0.402926797248768	no	1943	0.389238733147769	1279	NA	FT	PROTEIN PHOSPHORYLATION			Protein kinase of unknown cellular role; binds phosphatidylinositols and cardiolipin in a large-scale study	protein phosphorylation	protein kinase activity	cellular_component
YOL093W	YOL093W	TRM10	hom	Verified	0.245407257616945	0.403070555019581	no	1944	0.421167086194427	1402	NA	FT	RNA PROCESSING	NUCLEUS		tRNA methyltransferase; methylates the N-1 position of guanosine in tRNAs; protein abundance increases in response to DNA replication stress	tRNA methylation	tRNA (guanine) methyltransferase activity	nucleus|cytoplasm
YNR008W	YNR008W	LRO1	hom	Verified	0.24517822574852	0.403159217637586	no	1945	0.409380426640371	1354	NA	FT	LIPID METABOLISM	ENDOPLASMIC RETICULUM		Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase	lipid storage|triglyceride biosynthetic process	phospholipid:diacylglycerol acyltransferase activity	lipid particle|perinuclear endoplasmic reticulum
YGL241W	YGL241W	KAP114	hom	Verified	0.243648178437642	0.403751655743198	no	1946	0.395594845736853	1294	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS		Karyopherin, responsible for nuclear import of specific proteins; cargoes include Spt15p, Sua7p, histones H2A and H2B, and Nap1p; amino terminus shows similarity to those of other importins, particularly Cse1p; localization is primarily nuclear; function is regulated by sumoylation; protein abundance increases in response to DNA replication stress	protein import into nucleus|transcription factor import into nucleus	protein transporter activity	integral to membrane|nucleus|cytoplasm
YIR004W	YIR004W	DJP1	hom	Verified	0.243358130634683	0.403863987916793	no	1947	0.384081620937693	1280	NA	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION			Cytosolic J-domain-containing protein, required for peroxisomal protein import and involved in peroxisome assembly, homologous to E. coli DnaJ	protein import into peroxisome matrix	chaperone binding	cytosol
YDL188C	YDL188C	PPH22	hom	Verified	0.243279233229437	0.403894545345353	no	1948	0.402508285544152	1328	NA	FT	CELL CYCLE|TRANSLATION|CELL DIVISION|CYTOSKELETON ORGANIZATION	NUCLEUS|CHROMOSOME		Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; PPH22 has a paralog, PPH21, that arose from the whole genome duplication	actin filament organization|budding cell bud growth|G1/S transition of mitotic cell cycle|protein dephosphorylation|mitotic cell cycle spindle assembly checkpoint|regulation of translation	protein serine/threonine phosphatase activity	condensed nuclear chromosome, centromeric region
YKL214C	YKL214C	YRA2	hom	Verified	0.242737660127574	0.404104315611018	no	1949	0.395378820720416	1329	NA	FT	RNA LOCALIZATION	NUCLEUS		Member of the REF (RNA and export factor binding proteins) family; when overexpressed, can substitute for the function of Yra1p in export of poly(A)+ mRNA from the nucleus	poly(A)+ mRNA export from nucleus	RNA binding	nucleus
YPL138C	YPL138C	SPP1	hom	Verified	0.241551120905817	0.404564000205739	no	1950	0.405860342495293	1362	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS		Subunit of COMPASS (Set1C), a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; interacts with Orc2p; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein	histone H3-K4 methylation|regulation of transcription, DNA-dependent|chromatin silencing at telomere	histone methyltransferase activity (H3-K4 specific)|chromatin binding|methylated histone residue binding	Set1C/COMPASS complex
YGL255W	YGL255W	ZRT1	hom	Verified	0.241245775468776	0.404682317337168	no	1951	0.389907566334794	1283	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor	high-affinity zinc ion transport	high affinity zinc uptake transmembrane transporter activity	integral to membrane|integral to plasma membrane
YDR501W	YDR501W	PLM2	hom	Verified	0.24093075059425	0.404804394251334	no	1952	0.388077219055221	1289	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; induced in response to DNA damaging agents and deletion of telomerase; PLM2 has a paralog, TOS4, that arose from the whole genome duplication	response to DNA damage stimulus	chromatin binding	nuclear chromatin
YNL273W	YNL273W	TOF1	hom	Verified	0.239674616876714	0.405291257129604	no	1953	0.406032132336329	1327	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Subunit of a replication-pausing checkpoint complex (Tof1p-Mrc1p-Csm3p) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase	DNA repair|DNA replication checkpoint|maintenance of DNA repeat elements|replication fork arrest|replication fork protection|DNA replication|mitotic sister chromatid cohesion	molecular_function	nuclear chromosome|replication fork protection complex|nuclear replication fork
YKR093W	YKR093W	PTR2	hom	Verified	0.238714290642411	0.405663567371892	no	1954	0.418069140820644	1418	NA	FF|FT	PROTEIN LOCALIZATION	PLASMA MEMBRANE		Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p	dipeptide transport|tripeptide transport|peptide transport	dipeptide transporter activity|tripeptide transporter activity|peptide transporter activity	integral to membrane|plasma membrane
YML084W_d	YML084W	YML084W	hom	Dubious	0.238040288944868	0.405924923045119	no	1955	0.385877264029807	1290	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDL219W	YDL219W	DTD1	hom	Verified	0.237915797134959	0.405973201462785	no	1956	0.38447566550688	1271	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION			D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes	Unknown	D-leucyl-tRNA(Leu) deacylase activity|D-tyrosyl-tRNA(Tyr) deacylase activity	cytoplasm
YDR153C	YDR153C	ENT5	hom	Verified	0.237541863441683	0.406118223027555	no	1957	0.395988494992217	1303	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM		Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin	late endosome to vacuole transport via multivesicular body sorting pathway|early endosome to Golgi transport|Golgi to endosome transport	clathrin binding|phosphatidylinositol-3,5-bisphosphate binding	endosome|clathrin vesicle coat|cytoplasm
YER053C	YER053C	PIC2	hom	Verified	0.236413949823118	0.406555736282558	no	1958	0.380881475519732	1236	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature	phosphate ion transport|transmembrane transport	inorganic phosphate transmembrane transporter activity	mitochondrion|integral to membrane
YKL023W_p	YKL023W	YKL023W	hom	Uncharacterized	0.23637375821329	0.406571328605947	no	1959	0.40453273442601	1323	NA					Putative protein of unknown function, predicted by computational methods to be involved in mRNA degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YDL155W	YDL155W	CLB3	hom	Verified	0.236198152422416	0.406639456558859	no	1960	0.409399208720196	1353	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	NUCLEUS		B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress	G2/M transition of mitotic cell cycle|S phase of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|positive regulation of spindle pole body separation	cyclin-dependent protein kinase regulator activity	nucleus|cytoplasm
YDL057W_p	YDL057W	YDL057W	hom	Uncharacterized	0.236046033584596	0.40669847480706	no	1961	0.385155666530306	1292	NA					Putative protein of unknown function; YDL057W is not an essential gene	biological_process	molecular_function	cellular_component
YDL133C-A	YDL133C-A	RPL41B	hom	Verified	0.236006627602852	0.406713763673473	no	1962	0.400892515915579	1304	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YLR184W_d	YLR184W	YLR184W	hom	Dubious	0.235773049707852	0.406804390935718	no	1963	0.377862031054004	1260	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YBR095C	YBR095C	RXT2	hom	Verified	0.234913043707857	0.407138112708041	no	1964	0.426435219989525	1381	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Subunit of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth	conjugation with cellular fusion|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of transcription from RNA polymerase II promoter|negative regulation of chromatin silencing at telomere|negative regulation of chromatin silencing at rDNA|invasive growth in response to glucose limitation	histone deacetylase activity	Rpd3L-Expanded complex|nucleus|Rpd3L complex
YLR053C_p	YLR053C	YLR053C	hom	Uncharacterized	0.234669964347774	0.407232450881274	no	1965	0.393292977833911	1290	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YOR359W	YOR359W	VTS1	hom	Verified	0.234069703545798	0.407465432852489	no	1966	0.426989892293024	1413	NA	FT	PROTEIN LOCALIZATION|RNA PROCESSING	NUCLEUS		Flap-structured DNA-binding and RNA-binding protein; stimulates deadenylation-dependent mRNA degradation mediated by the CCR4-NOT deadenylase complex; member of the Smaug (Smg) family of post-transcriptional regulators which bind RNA through a conserved sterile alpha motif (SAM) domain that interacts with Smg recognition element (SREs) containing transcripts; stimulates Dna2p endonuclease activity	nuclear-transcribed mRNA catabolic process|positive regulation of endodeoxyribonuclease activity|nuclear-transcribed mRNA poly(A) tail shortening	flap-structured DNA binding|RNA binding	cytosol|nucleus|cytoplasmic mRNA processing body
YPL092W	YPL092W	SSU1	hom	Verified	0.233261646138011	0.407779119554185	no	1967	0.414999368414538	1356	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein	sulfite transport	sulfite transmembrane transporter activity	integral to membrane|plasma membrane
YOL046C_d	YOL046C	YOL046C	hom	Dubious	0.233184043734799	0.407809247808554	no	1968	0.380713301471196	1259	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data;almost completely overlaps the verified gene PSK2/YOL045W	Unknown	Unknown	Unknown
YMR136W	YMR136W	GAT2	hom	Verified	0.232892717893949	0.407922356631333	no	1969	0.407514592304021	1303	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine	regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding RNA polymerase II transcription factor activity	nucleus
YGL260W_p	YGL260W	YGL260W	hom	Uncharacterized	0.232481608526203	0.408081985106166	no	1970	0.405103244108382	1365	NA					Putative protein of unknown function; transcription is significantly increased in a NAP1 deletion background; deletion mutant has increased accumulation of nickel and selenium	biological_process	molecular_function	cellular_component
YDR185C	YDR185C	UPS3	hom	Verified	0.232323010527891	0.408143570746826	no	1971	0.410286604234669	1365	NA	FT	MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial protein of unknown function; similar to Ups1p and Ups2p which are involved in regulation of mitochondrial cardiolipin and phosphatidylethanolamine levels; null is viable but interacts synthetically with ups1 and ups2 mutations	mitochondrion morphogenesis	molecular_function	extrinsic to mitochondrial inner membrane|mitochondrion|mitochondrial intermembrane space
YML054C-A_p	YML054C-A	YML054C-A	hom	Uncharacterized	0.231650553968052	0.408404719460632	no	1972	0.390622498490196	1265	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YDL210W	YDL210W	UGA4	hom	Verified	0.231357784146102	0.408518429430533	no	1973	0.396340441515337	1288	NA					Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane	gamma-aminobutyric acid transport|putrescine transport|transmembrane transport	putrescine transmembrane transporter activity|gamma-aminobutyric acid:hydrogen symporter activity	fungal-type vacuole membrane|integral to membrane
YOR318C_d	YOR318C	YOR318C	hom	Dubious	0.230783013381314	0.408741689200343	no	1974	0.409982789856706	1363	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo	Unknown	Unknown	Unknown
YML054C	YML054C	CYB2	hom	Verified	0.230677956127513	0.408782500078359	no	1975	0.360828992650865	1210	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions	lactate metabolic process	L-lactate dehydrogenase (cytochrome) activity	mitochondrion|mitochondrial intermembrane space
YIL041W	YIL041W	GVP36	hom	Verified	0.230638421137352	0.408797858223684	no	1976	0.419432152819387	1382	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		BAR domain-containing protein that localizes to both early and late Golgi vesicles; required for adaptation to varying nutrient concentrations, fluid-phase endocytosis, polarization of the actin cytoskeleton, and vacuole biogenesis	vacuole organization|endocytosis|establishment or maintenance of actin cytoskeleton polarity	molecular_function	integral to Golgi membrane|cytoplasm
YGR200C	YGR200C	ELP2	hom	Verified	0.230095270325873	0.409008870018655	no	1977	0.416180743418776	1379	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin	regulation of transcription from RNA polymerase II promoter|protein urmylation|tRNA wobble uridine modification	molecular_function	Elongator holoenzyme complex|nucleus|cytoplasm
YBR165W	YBR165W	UBS1	hom	Verified	0.229797960598256	0.409124384764292	no	1978	0.399081747748169	1321	NA	FT	PROTEIN LOCALIZATION	NUCLEUS		Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity	protein export from nucleus|protein ubiquitination	molecular_function	nucleus
YBL089W	YBL089W	AVT5	hom	Verified	0.228461332137955	0.409643806863944	no	1979	0.434712017029308	1419	NA					Putative transporter; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; AVT5 has a paralog, AVT6, that arose from the whole genome duplication	transport	transporter activity	integral to membrane
YPL272C_p	YPL272C	YPL272C	hom	Uncharacterized	0.227609933456829	0.409974748428471	no	1980	0.43361062479224	1432	NA					Putative protein of unknown function; gene expression induced in response to ketoconazole; YPL272C is not an essential gene	biological_process	molecular_function	cellular_component
YIR042C_p	YIR042C	YIR042C	hom	Uncharacterized	0.227449612066102	0.410037073081333	no	1981	0.402827280008162	1322	NA					Putative protein of unknown function; YIR042C is a non-essential gene	biological_process	molecular_function	cellular_component
YHR113W	YHR113W	APE4	hom	Verified	0.227083508437722	0.410179403727895	no	1982	0.405359761502825	1368	NA	FT	PROTEOLYSIS			Cytoplasmic aspartyl aminopeptidase that may also function in the vacuole; CVT pathway cargo protein; cleaves unblocked N-terminal acidic amino acids from peptide substrates; forms a 12-subunit homo-oligomer; M18 metalloprotease family	proteolysis	aminopeptidase activity	fungal-type vacuole lumen|ribosome|cytoplasm
YOL037C_d	YOL037C	YOL037C	hom	Dubious	0.226567253032051	0.410380129206178	no	1983	0.424300746431801	1397	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOL036W	Unknown	Unknown	Unknown
YEL016C	YEL016C	NPP2	hom	Verified	0.226086308742873	0.410567146481177	no	1984	0.415105964053891	1377	NA	FT	NUCLEOTIDE METABOLISM			Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp1p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; NPP2 has a paralog, NPP1, that arose from the whole genome duplication	nucleoside triphosphate metabolic process	nucleotide diphosphatase activity|nucleoside-triphosphate diphosphatase activity|nucleoside-triphosphatase activity|phosphodiesterase I activity	cellular_component
YOR351C	YOR351C	MEK1	hom	Verified	0.22595865723978	0.410616787739226	no	1985	0.41231162472446	1366	NA	FT	CELL CYCLE|PROTEIN PHOSPHORYLATION	NUCLEUS		Meiosis-specific serine/threonine protein kinase, functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids	meiosis|meiotic recombination checkpoint|protein phosphorylation	protein serine/threonine kinase activity|protein kinase activity	nucleus
YOL079W_d	YOL079W	YOL079W	hom	Dubious	0.225221209983249	0.410903595051738	no	1986	0.428874469910677	1405	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKR080W	YKR080W	MTD1	hom	Verified	0.224983343532403	0.410996116022738	no	1987	0.418325826170116	1376	NA	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	NUCLEUS		NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline	folic acid-containing compound biosynthetic process|one-carbon metabolic process|purine nucleobase biosynthetic process	methylenetetrahydrofolate dehydrogenase (NAD+) activity	cytosol
YCR043C_p	YCR043C	YCR043C	hom	Uncharacterized	0.224959023100257	0.411005576021727	no	1988	0.417075867288871	1370	NA	FT		GOLGI APPARATUS|SITE OF POLARIZED GROWTH		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene	biological_process	molecular_function	Golgi apparatus|mating projection tip
YDR078C	YDR078C	SHU2	hom	Verified	0.224149093027015	0.411320646732713	no	1989	0.416225567811093	1376	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function	recombinational repair|maintenance of rDNA|error-free translesion synthesis	molecular_function	Shu complex
YKR023W_p	YKR023W	YKR023W	hom	Uncharacterized	0.21982799584037	0.41300255768504	no	1990	0.354957914589997	1205	NA	FT		NUCLEUS|MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion|cytoplasm
YMR083W	YMR083W	ADH3	hom	Verified	0.219521119210788	0.413122065147434	no	1991	0.413135168889282	1359	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production	NADH oxidation|fermentation|amino acid catabolic process to alcohol via Ehrlich pathway	alcohol dehydrogenase (NAD) activity	mitochondrion|mitochondrial matrix
YOR225W_d	YOR225W	YOR225W	hom	Dubious	0.219394963394988	0.413171196546692	no	1992	0.42061362833319	1408	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YHR202W_p	YHR202W	YHR202W	hom	Uncharacterized	0.219181622278789	0.413254285366725	no	1993	0.414191078605262	1384	NA	FT	NUCLEOTIDE METABOLISM			Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization	biological_process	molecular_function	cytosol|fungal-type vacuole
YDR127W	YDR127W	ARO1	hom	Verified	0.219101410621688	0.413285525975728	no	1994	0.46241500767197	1513	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS			Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids	aromatic amino acid family biosynthetic process	shikimate kinase activity|shikimate 3-dehydrogenase (NADP+) activity|3-phosphoshikimate 1-carboxyvinyltransferase activity|3-dehydroquinate dehydratase activity|3-dehydroquinate synthase activity	cytoplasm
YOR111W_p	YOR111W	YOR111W	hom	Uncharacterized	0.218712049162632	0.413437181171542	no	1995	0.400764781968801	1323	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YBR284W_p	YBR284W	YBR284W	hom	Uncharacterized	0.218544813235643	0.41350232306208	no	1996	0.416713182644338	1382	NA	FT	NUCLEOTIDE METABOLISM			Putative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic defect of quadruple aah1 ade8 amd1 his1 mutant; null mutant exhibits longer telomeres, altered Ty mobility, decreased resistance to rapamycin and wortmannin; induced in response to hydrostatic pressure; not an essential gene; YBR284W has a paralog, YJL070C, that arose from the whole genome duplication	biological_process	AMP deaminase activity|molecular_function	cellular_component
YDR165W	YDR165W	TRM82	hom	Verified	0.21527347310604	0.414777055087268	no	1997	0.441807742259059	1470	NA	FT	RNA PROCESSING	NUCLEUS		Catalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p	tRNA methylation	tRNA (guanine-N7-)-methyltransferase activity	tRNA methyltransferase complex|nucleus
YKL130C	YKL130C	SHE2	hom	Verified	0.215055885823148	0.414861873581888	no	1998	0.398870599189087	1308	NA	FT	RNA LOCALIZATION	NUCLEUS|SITE OF POLARIZED GROWTH		RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud	mating type switching|intracellular mRNA localization	mRNA binding	cellular bud tip|cytoplasm
YMR096W	YMR096W	SNZ1	hom	Verified	0.214951391752857	0.414902608208612	no	1999	0.400151066507249	1316	NA	FT	COFACTOR METABOLISM			Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins	pyridoxine metabolic process|thiamine biosynthetic process	protein binding	cellular_component
YPL262W	YPL262W	FUM1	hom	Verified	0.214368469871969	0.415129863767126	no	2000	0.399084611101955	1321	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria	fumarate metabolic process|tricarboxylic acid cycle	fumarate hydratase activity	cytosol|mitochondrion|mitochondrial matrix
YLR414C	YLR414C	PUN1	hom	Verified	0.212787266978719	0.415746447896158	no	2001	0.384427466517908	1251	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL WALL ORG/BIOGENESIS	PLASMA MEMBRANE		Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress	fungal-type cell wall organization|protein oligomerization	molecular_function	integral to membrane|membrane raft|plasma membrane|cellular bud|cytoplasm
YDR382W	YDR382W	RPP2B	hom	Verified	0.211754593212944	0.416149247250254	no	2002	0.407161228187615	1323	NA	FT	TRANSLATION		RIBOSOME	Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm	translational elongation|cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YDR046C	YDR046C	BAP3	hom	Verified	0.210973033436265	0.416454156974982	no	2003	0.395731469803885	1308	NA	FT		MITOCHONDRION|PLASMA MEMBRANE		Amino acid permease; involved in uptake of cysteine, leucine, isoleucine and valine; BAP3 has a paralog, BAP2, that arose from the whole genome duplication	amino acid transport|transmembrane transport	amino acid transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YOR003W	YOR003W	YSP3	hom	Verified	0.210083489019445	0.416801255891505	no	2004	0.412175642754827	1384	NA	FT	PROTEOLYSIS			Putative precursor to the subtilisin-like protease III	protein catabolic process	peptidase activity	cellular_component
YDR126W	YDR126W	SWF1	hom	Verified	0.209317440224794	0.417100218995955	no	2005	0.410745097197327	1342	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|CYTOSKELETON		Palmitoyltransferase that acts on transmembrane proteins, including the SNAREs Snc1p, Syn8p, Tlg1p and likely all SNAREs; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; may have a role in vacuole fusion	ascospore wall assembly|cortical actin cytoskeleton organization|establishment of cell polarity|vacuole fusion, non-autophagic|regulation of exocytosis|protein palmitoylation	palmitoyltransferase activity	integral to membrane|actin filament bundle|nuclear outer membrane-endoplasmic reticulum membrane network|actin cortical patch
YCR010C	YCR010C	ADY2	hom	Verified	0.20919919123086	0.417146371880573	no	2006	0.424239009727802	1395	NA	FT	CELL CYCLE|ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION|PLASMA MEMBRANE		Acetate transporter required for normal sporulation; phosphorylated in mitochondria; ADY2 has a paralog, ATO2, that arose from the whole genome duplication	nitrogen utilization|ammonium transport|acetate transport|transmembrane transport	acetate transmembrane transporter activity|ammonium transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YGL023C	YGL023C	PIB2	hom	Verified	0.20826096251347	0.417512605364295	no	2007	0.431615433693584	1442	NA	FT	VESICLE-MEDIATED TRANSPORT	MITOCHONDRION		Protein of unknown function; contains FYVE domain; similar to Fab1 and Vps27	biological_process	molecular_function	mitochondrion
YPL221W	YPL221W	FLC1	hom	Verified	0.207507821382424	0.4178066425141	no	2008	0.415783230171704	1373	NA	FT	CELL WALL ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH		Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance	protein folding|fungal-type cell wall biogenesis|FAD transport	FAD transmembrane transporter activity	integral to membrane|endoplasmic reticulum|fungal-type vacuole|cellular bud neck
YCR030C	YCR030C	SYP1	hom	Verified	0.207376201660816	0.417858033471964	no	2009	0.401372656720998	1288	NA	FT	CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH		Protein of unknown function that is involved in endocytic site formation; may regulate assembly and disassembly of the septin ring; colocalizes and interacts with septin subunits; potential role in actin cytoskeletal organization	septin cytoskeleton organization|actin cortical patch assembly	molecular_function	mating projection base|mating projection tip|cellular bud neck|cellular bud tip
YKL084W	YKL084W	HOT13	hom	Verified	0.206476234640868	0.418209463393898	no	2010	0.413023949575309	1381	NA	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Zinc-binding mitochondrial intermembrane space (IMS) protein involved in a disulfide relay system for IMS import of cysteine-containing proteins; binds Mia40p and stimulates its Erv1p-dependent oxidation, probably by sequestering zinc	protein import into mitochondrial intermembrane space	zinc ion binding	mitochondrial intermembrane space
YLR210W	YLR210W	CLB4	hom	Verified	0.206003978968072	0.418393901600839	no	2011	0.415483605020126	1351	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	NUCLEUS|CYTOSKELETON		B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation	G2/M transition of mitotic cell cycle|S phase of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|positive regulation of spindle pole body separation	cyclin-dependent protein kinase regulator activity	nucleus|spindle pole body|cytoplasm
YBR073W	YBR073W	RDH54	hom	Verified	0.205973218308531	0.418405915718155	no	2012	0.452104847634398	1499	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS		DNA-dependent ATPase; stimulates strand exchange by modifying the topology of double-stranded DNA; involved in recombinational repair of DNA double-strand breaks during mitosis and meiosis; proposed to be involved in crossover interference; interacts with Dmc1p; stimulates Dmc1p and Rad51p	DNA geometric change|heteroduplex formation|meiotic sister chromatid segregation|reciprocal meiotic recombination|double-strand break repair via break-induced replication	DNA-dependent ATPase activity|DNA translocase activity	nucleus
YGR254W	YGR254W	ENO1	hom	Verified	0.205804493214208	0.418471815628752	no	2013	0.407026758420783	1358	NA	FT	MEMBRANE ORGANIZATION|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Enolase I, a phosphopyruvate hydratase; catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is repressed in response to glucose; protein abundance increases in response to DNA replication stress	regulation of vacuole fusion, non-autophagic|gluconeogenesis|glycolysis	phosphopyruvate hydratase activity	mitochondrion|phosphopyruvate hydratase complex|plasma membrane|fungal-type vacuole|cytoplasm
YCL026C-A	YCL026C-A	FRM2	hom	Verified	0.203376991945674	0.419420190889215	no	2014	0.400342177504775	1325	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	NUCLEUS		Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin	cellular response to oxidative stress|negative regulation of fatty acid metabolic process	oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor	nucleus|cytoplasm
YMR244W_p	YMR244W	YMR244W	hom	Uncharacterized	0.203292301902558	0.419453286048192	no	2015	0.369107600666421	1210	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YOR214C_p	YOR214C	YOR214C	hom	Uncharacterized	0.203233509481576	0.419476261274399	no	2016	0.424702873066235	1417	NA					Putative protein of unknown function; YOR214C is not an essential gene	biological_process	molecular_function	fungal-type cell wall
YBR272C	YBR272C	HSM3	hom	Verified	0.201321076020439	0.42022376182555	no	2017	0.416464005549872	1393	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE	NUCLEUS		Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); involved in DNA mismatch repair during slow growth; weak similarity to Msh1p; related to human 19S subunit S5b; structural study suggests Hsm3p is a scaffold protein for Rpt1p-Rpt2p complex formation	mismatch repair|proteasome regulatory particle assembly	molecular_function	cytosol|proteasome regulatory particle, base subcomplex|nucleus|cytoplasm
YDL019C	YDL019C	OSH2	hom	Verified	0.200742342682827	0.420450024453237	no	2018	0.437401861116686	1423	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability	endocytosis|maintenance of cell polarity|sterol transport|exocytosis	lipid binding|oxysterol binding|sterol transporter activity|1-phosphatidylinositol binding	endoplasmic reticulum|plasma membrane|cortical endoplasmic reticulum|cellular bud neck
YAL061W_p	YAL061W	BDH2	hom	Uncharacterized	0.200728349161153	0.420455495711459	no	2019	0.389418745065971	1302	NA	FT	OXIDATION-REDUCTION PROCESS	NUCLEUS		Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3	biological_process	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	nucleus|cytoplasm
YNL203C_d	YNL203C	YNL203C	hom	Dubious	0.200323836738043	0.420613660673443	no	2020	0.423606577577517	1413	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YBR182C	YBR182C	SMP1	hom	Verified	0.199875303046317	0.420789053001519	no	2021	0.406847085190166	1322	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Putative transcription factor of the MADS-box family; involved in regulating the response to osmotic stress; SMP1 has a paralog, RLM1, that arose from the whole genome duplication	positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress	DNA binding, bending|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus|cytoplasm
YIR021W-A_p	YIR021W-A	YIR021W-A	hom	Uncharacterized	0.199857711847223	0.420795932095001	no	2022	0.422229297120431	1397	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YGR235C	YGR235C	MOS2	hom	Verified	0.198727743337129	0.421237860400522	no	2023	0.444272275545607	1477	NA	FT	MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial inner membrane protein; non-essential component of the mitochondrial inner membrane organizing system (MINOS, MitOS, or MICOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture	cristae formation	molecular_function	mitochondrion|mitochondrial crista junction|integral to mitochondrial inner membrane
YNL044W	YNL044W	YIP3	hom	Verified	0.197876593735283	0.421570808783285	no	2024	0.423761864912573	1404	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Protein localized to COPII vesicles, proposed to be involved in ER to Golgi transport; interacts with members of the Rab GTPase family and Yip1p; also interacts with Rtn1p	ER to Golgi vesicle-mediated transport	molecular_function	Golgi apparatus|endoplasmic reticulum|ER to Golgi transport vesicle
YBR016W	YBR016W	YBR016W	hom	Verified	0.19662011004616	0.422062416130509	no	2025	0.428339087052478	1413	NA	FT		PLASMA MEMBRANE		Tail-anchored plasma membrane protein with a conserved CYSTM module; predicted to be palmitoylated; has similarity to hydrophilins, which are involved in the adaptive response to hyperosmotic conditions; YBR016W has a paralog, YDL012C, that arose from the whole genome duplication	biological_process	molecular_function	cellular bud membrane|plasma membrane|mating projection membrane
YOR138C	YOR138C	RUP1	hom	Verified	0.195781552867933	0.422390574664029	no	2026	0.433079706925228	1414	NA	FT		NUCLEUS		Protein that regulates Rsp5p, which is a HECT ubiquitin ligase; has a WW domain consensus motif of PPPSY (residues 131-135) that mediates binding of Rsp5p to Ubp2p; contains an UBA domain; relative distribution to the nucleus increases upon DNA replication stress	protein deubiquitination	protein binding	nucleus|cytoplasm
YDL159W-A_p	YDL159W-A	YDL159W-A	hom	Uncharacterized	0.19567111932955	0.422433795424418	no	2027	0.425903810550924	1376	NA					Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species	biological_process	molecular_function	cellular_component
YAL045C_d	YAL045C	YAL045C	hom	Dubious	0.195178543280963	0.422626588002651	no	2028	0.405878318419951	1345	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps YAL044W-A	Unknown	Unknown	Unknown
YLR252W_d	YLR252W	YLR252W	hom	Dubious	0.194440655822448	0.422915429294082	no	2029	0.433502705191714	1448	NA					Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SYM1, a mitochondrial protein involved in ethanol metabolism	Unknown	Unknown	Unknown
YMR177W	YMR177W	MMT1	hom	Verified	0.194313022280977	0.42296539483014	no	2030	0.421247707182113	1402	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt2p	cellular iron ion homeostasis	molecular_function	mitochondrion|integral to membrane
YLR326W_p	YLR326W	YLR326W	hom	Uncharacterized	0.194010006938884	0.423084023186979	no	2031	0.412640791422403	1323	NA					Putative protein of unknown function, predicted to be palmitoylated	biological_process	molecular_function	cellular_component
YJR091C	YJR091C	JSN1	hom	Verified	0.193773413917927	0.42317665252537	no	2032	0.408825648063939	1318	NA	FT	PROTEIN LOCALIZATION	MITOCHONDRION		Member of the Puf family of RNA-binding proteins, interacts with mRNAs encoding membrane-associated proteins; involved in localizing the Arp2/3 complex to mitochondria; overexpression causes increased sensitivity to benomyl	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|cellular protein complex localization|establishment of mitochondrion localization	mRNA binding	external side of mitochondrial outer membrane
YBL003C	YBL003C	HTA2	hom	Verified	0.193200232919576	0.423401078164498	no	2033	0.424356701276361	1412	NA	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical (see also HTA1) subtypes; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p	DNA repair|chromatin assembly or disassembly	DNA binding	replication fork protection complex|nuclear nucleosome
YKL066W_d	YKL066W	YKL066W	hom	Dubious	0.193123871967515	0.423430978722549	no	2034	0.390155214187169	1293	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species; partially overlaps the verified gene YNK1	Unknown	Unknown	Unknown
YGR040W	YGR040W	KSS1	hom	Verified	0.192670801517782	0.423608395989552	no	2035	0.440281669058818	1467	NA	FT	CELL CYCLE|SIGNALING|PROTEIN PHOSPHORYLATION	NUCLEUS		Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains	pheromone-dependent signal transduction involved in conjugation with cellular fusion|signal transduction involved in filamentous growth|negative regulation of sequence-specific DNA binding transcription factor activity|protein phosphorylation|invasive growth in response to glucose limitation	MAP kinase activity|protein kinase activity|transcription factor binding	nucleus
YDR497C	YDR497C	ITR1	hom	Verified	0.192461146676631	0.423690499699432	no	2036	0.416944325805653	1361	NA	FT		PLASMA MEMBRANE		Myo-inositol transporter; has strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p; relative distribution to the vacuole increases upon DNA replication stress	myo-inositol transport|transmembrane transport	myo-inositol transmembrane transporter activity	integral to membrane|plasma membrane|membrane
YGL211W	YGL211W	NCS6	hom	Verified	0.192158505424125	0.423809024004718	no	2037	0.421749461919452	1400	NA	FT	RNA PROCESSING	MITOCHONDRION		Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae	tRNA wobble position uridine thiolation|protein urmylation|tRNA wobble uridine modification	tRNA binding	cytosol|mitochondrion
YOL053W	YOL053W	AIM39	hom	Verified	0.191961277179262	0.423886268806739	no	2038	0.400308622617709	1311	NA	FT		MITOCHONDRION		Putative protein of unknown function; null mutant displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	cellular_component
YLR113W	YLR113W	HOG1	hom	Verified	0.191412405058162	0.424101250959861	no	2039	0.450540419620485	1488	NA	FT	TRANSCRIPTION FROM RNA POL II|SIGNALING|PROTEIN PHOSPHORYLATION	NUCLEUS		Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNA Pol II in response to osmotic shock; acts via three independent osmosensors; mitophagy-specific regulator; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p; protein abundance increases in response to DNA replication stress	negative regulation of transcription from RNA polymerase II promoter by pheromones|protein phosphorylation|hyperosmotic response|response to arsenic-containing substance|osmosensory signaling pathway|positive regulation of transcription from RNA polymerase II promoter|cellular response to heat	MAP kinase activity	nucleus|cytoplasm
YBR263W	YBR263W	SHM1	hom	Verified	0.190725072862451	0.424370496980664	no	2040	0.389493563573721	1273	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Mitochondrial serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine	serine family amino acid biosynthetic process|one-carbon metabolic process	glycine hydroxymethyltransferase activity	mitochondrion
YBL071W-A	YBL071W-A	KTI11	hom	Verified	0.19027677085134	0.424546127645585	no	2041	0.467944042821441	1566	NA	FT	RNA PROCESSING	NUCLEUS		Zn-ribbon protein that co-purifies with Dph1 and Dph2 in a complex required for synthesis of diphthamide on translation factor eEF2 and with Elongator subunits Iki3p, Elp2p, and Elp3p involved in modification of wobble nucleosides in tRNAs	peptidyl-diphthamide biosynthetic process from peptidyl-histidine|tRNA wobble uridine modification	electron carrier activity|iron ion binding|zinc ion binding	nucleus|cytoplasm
YOR152C_p	YOR152C	YOR152C	hom	Uncharacterized	0.190241370582147	0.424559996999256	no	2042	0.399623165086323	1322	NA					Putative protein of unknown function; YOR152C is not an essential gene	biological_process	molecular_function	membrane
YOR133W	YOR133W	EFT1	hom	Verified	0.189746819959158	0.424753765101876	no	2043	0.429943751022405	1429	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM		RIBOSOME	Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication	translational elongation	translation elongation factor activity	ribosome
YIL114C	YIL114C	POR2	hom	Verified	0.189426568281528	0.42487925146404	no	2044	0.421819369271167	1382	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Putative mitochondrial porin (voltage-dependent anion channel); not required for mitochondrial membrane permeability or mitochondrial osmotic stability; POR2 has a paralog, POR1, that arose from the whole genome duplication	DNA transport|ion transport|cell redox homeostasis	voltage-gated anion channel activity	mitochondrial outer membrane|mitochondrion|integral to membrane
YKR036C	YKR036C	CAF4	hom	Verified	0.189220629097755	0.424959950017756	no	2045	0.409419632016232	1357	NA	FT	TRANSCRIPTION FROM RNA POL II|MITOCHONDRION ORGANIZATION|PEROXISOME ORGANIZATION	NUCLEUS|MITOCHONDRION		WD40 repeat-containing protein associated with the CCR4-NOT complex; interacts in a Ccr4p-dependent manner with Ssn2p; also interacts with Fis1p, Mdv1p and Dnm1p and plays a role in mitochondrial fission; CAF4 has a paralog, MDV1, that arose from the whole genome duplication	peroxisome fission|mitochondrial fission|regulation of transcription from RNA polymerase II promoter	molecular_function	mitochondrion|CCR4-NOT complex
YIR021W	YIR021W	MRS1	hom	Verified	0.189178325931287	0.424976527166846	no	2046	0.407410154544918	1347	NA	FT	RNA PROCESSING	MITOCHONDRION		Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA	Group I intron splicing	endodeoxyribonuclease activity|RNA binding	mitochondrion
YGL205W	YGL205W	POX1	hom	Verified	0.188939162144661	0.42507024968452	no	2047	0.414970776278213	1356	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS			Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix	fatty acid beta-oxidation using acyl-CoA oxidase|fatty acid beta-oxidation	acyl-CoA oxidase activity	peroxisomal matrix
YCR019W	YCR019W	MAK32	hom	Verified	0.188403160538052	0.425280311156199	no	2048	0.425767299126497	1436	NA					Protein necessary for structural stability of L-A double-stranded RNA-containing particles	interspecies interaction between organisms	molecular_function	cellular_component
YDR192C	YDR192C	NUP42	hom	Verified	0.188262943001949	0.425335266550461	no	2049	0.43838433192497	1428	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; interacts with Gle1p	poly(A)+ mRNA export from nucleus|NLS-bearing substrate import into nucleus|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|mRNA export from nucleus in response to heat stress|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	nucleocytoplasmic transporter activity|structural constituent of nuclear pore	nuclear pore central transport channel|integral to membrane|nuclear pore cytoplasmic filaments|nuclear pore
YPR155C	YPR155C	NCA2	hom	Verified	0.188200295026638	0.425359820611479	no	2050	0.418098342394822	1396	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Protein involved in regulation of mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; functions with Nca3p	mRNA metabolic process|aerobic respiration	molecular_function	mitochondrial outer membrane|mitochondrion
YNL121C	YNL121C	TOM70	hom	Verified	0.187884169734412	0.425483726232077	no	2051	0.440086244667812	1440	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Component of the TOM (translocase of outer membrane) complex; involved in the recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins; TOM70 has a paralog, TOM71, that arose from the whole genome duplication	protein import into mitochondrial matrix|protein import into mitochondrial inner membrane	mitochondrion targeting sequence binding|protein channel activity	mitochondrial outer membrane|mitochondrion|integral to membrane|integral to mitochondrial outer membrane|mitochondrial outer membrane translocase complex
YKR078W	YKR078W	YKR078W	hom	Verified	0.187305425267638	0.425710584759052	no	2052	0.432896283243055	1409	NA					Cytoplasmic protein of unknown function, has similarity to Vps5p; potential Cdc28p substrate; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P)	biological_process	phosphatidylinositol-3-phosphate binding	cytoplasm
YBR199W	YBR199W	KTR4	hom	Verified	0.186667016815605	0.425960859133145	no	2053	0.405929357741702	1349	NA	FT	CARBOHYDRATE METABOLISM	GOLGI APPARATUS		Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family	protein N-linked glycosylation	mannosyltransferase activity	Golgi apparatus
YOR097C_p	YOR097C	YOR097C	hom	Uncharacterized	0.186637553883321	0.425972410166137	no	2054	0.433003070995366	1451	NA					Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; YOR097C is not an essential gene	biological_process	molecular_function	cellular_component
YDR184C	YDR184C	ATC1	hom	Verified	0.186240725843268	0.426127994001794	no	2055	0.437602241969583	1451	NA	FT	CELL CYCLE|CELL DIVISION	NUCLEUS		Nuclear protein; possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding pattern; relative distribution to the nucleus decreases upon DNA replication stress	bipolar cellular bud site selection|response to stress	molecular_function	nucleus
YOR161C-C_p	YOR161C-C	YOR161C-C	hom	Uncharacterized	0.184685948925632	0.426737683859434	no	2056	0.423969792701001	1413	NA					Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YDL086W_p	YDL086W	YDL086W	hom	Uncharacterized	0.184279651462304	0.426897038166266	no	2057	0.409555177093936	1341	NA	FT		MITOCHONDRION		Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene	biological_process	carboxymethylenebutenolidase activity	mitochondrion|cytoplasm
YGL227W	YGL227W	VID30	hom	Verified	0.183113771701631	0.427354375108849	no	2058	0.429198747829167	1406	NA	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS	NUCLEUS		Central component of GID Complex, involved in FBPase degradation; interacts strongly with Gid8p to serve as a scaffold for other GID Complex subunits; contains SPRY domain and 3 domains that are also found in Gid8p - LisH, CTLH, and CRA; required for association of Vid vesicles and actin patches in vacuole import and degradation pathway; shifts the balance of nitrogen metabolism toward glutamate production; localizes to the nucleus and the cytoplasm	regulation of nitrogen utilization|negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|vacuolar protein catabolic process	molecular_function	nucleus|GID complex|cytoplasm
YKL220C	YKL220C	FRE2	hom	Verified	0.182982661812082	0.427405811399358	no	2059	0.4131314681354	1369	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY	PLASMA MEMBRANE		Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels	iron ion transport|copper ion import	ferric-chelate reductase activity	integral to membrane|plasma membrane
YOR323C	YOR323C	PRO2	hom	Verified	0.18292844184682	0.427427083030274	no	2060	0.468683033392686	1544	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	NUCLEUS		Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis	proline biosynthetic process	glutamate-5-semialdehyde dehydrogenase activity	nucleus|cytoplasm
YGL115W	YGL115W	SNF4	hom	Verified	0.18268514736642	0.427522535160293	no	2061	0.417972332859101	1364	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|PLASMA MEMBRANE		Activating gamma subunit of the AMP-activated Snf1p kinase complex; additional subunits of the complex are Snf1p and a Sip1p/Sip2p/Gal83p family member; activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis; protein abundance increases in response to DNA replication stress	positive regulation of gluconeogenesis|peroxisome organization|protein phosphorylation|replicative cell aging|regulation of transcription from RNA polymerase II promoter	AMP-activated protein kinase activity|protein serine/threonine kinase activator activity	AMP-activated protein kinase complex|plasma membrane|nucleus|nuclear envelope lumen|cytoplasm
YJL196C	YJL196C	ELO1	hom	Verified	0.182253977264035	0.427691707265387	no	2062	0.420459292982766	1377	NA	FT	KETONE METABOLISM|LIPID METABOLISM			Elongase I, medium-chain acyl elongase; catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids; ELO1 has a paralog, FEN1, that arose from the whole genome duplication	fatty acid elongation, unsaturated fatty acid	fatty acid elongase activity	integral to membrane|membrane
YIR035C_p	YIR035C	YIR035C	hom	Uncharacterized	0.182195710975517	0.427714569403947	no	2063	0.408091202218027	1334	NA	FT	OXIDATION-REDUCTION PROCESS			Putative cytoplasmic short-chain dehydrogenase/reductase	biological_process	molecular_function	integral to membrane|cytoplasm
YER045C	YER045C	ACA1	hom	Verified	0.181072548312142	0.42815531583723	no	2064	0.42530818149192	1407	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		ATF/CREB family basic leucine zipper (bZIP) transcription factor; binds as a homodimer to the ATF/CREB consensus sequence TGACGTCA; important for carbon source utilization; target genes include GRE2 and COS8; ACA1 has a paralog, CST6, that arose from the whole genome duplication	positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YOR018W	YOR018W	ROD1	hom	Verified	0.179862707013216	0.428630176584567	no	2065	0.428200843394268	1402	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	PLASMA MEMBRANE		Membrane protein, binds the ubiquitin ligase Rsp5p via its 2 PY motifs; overexpression confers resistance to the GST substrate o-dinitrobenzene, zinc, and calcium; proposed to regulate the endocytosis of plasma membrane proteins; protein abundance increases in response to DNA replication stress; ROD1 has a paralog, ROG3, that arose from the whole genome duplication	response to drug|ubiquitin-dependent endocytosis	ubiquitin protein ligase binding	plasma membrane
YOR082C_d	YOR082C	YOR082C	hom	Dubious	0.179336852616972	0.42883660584235	no	2066	0.431382949405973	1403	NA					Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene YOR083W	Unknown	Unknown	Unknown
YPL056C_p	YPL056C	LCL1	hom	Uncharacterized	0.178443737514644	0.429187251444301	no	2067	0.409976466574063	1358	NA	FT		PLASMA MEMBRANE		Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan	biological_process	molecular_function	cellular_component
YGL257C	YGL257C	MNT2	hom	Verified	0.177884686299485	0.429406768800122	no	2068	0.43602314662971	1420	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans	protein O-linked glycosylation	alpha-1,3-mannosyltransferase activity	cellular_component
YGR260W	YGR260W	TNA1	hom	Verified	0.176069429545878	0.430119698696135	no	2069	0.437150400554492	1448	NA	FT		MITOCHONDRION|PLASMA MEMBRANE		High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA)	nicotinamide mononucleotide transport	nicotinamide mononucleotide transmembrane transporter activity	mitochondrion|integral to membrane|integral to plasma membrane
YMR170C	YMR170C	ALD2	hom	Verified	0.174968312891478	0.430552266058337	no	2070	0.424725893324546	1394	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS			Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p	cellular aldehyde metabolic process|beta-alanine biosynthetic process|polyamine catabolic process	aldehyde dehydrogenase (NAD) activity	cytoplasm
YDR151C	YDR151C	CTH1	hom	Verified	0.174187890468639	0.430858901031063	no	2071	0.436655974486856	1426	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	NUCLEUS		Member of the CCCH zinc finger family; has similarity to mammalian Tis11 protein, which activates transcription and also has a role in mRNA degradation; may function with Tis11p in iron homeostasis	nuclear-transcribed mRNA catabolic process|cellular iron ion homeostasis	mRNA binding	nucleus
YGR123C	YGR123C	PPT1	hom	Verified	0.173940122818753	0.430956259890771	no	2072	0.436319437182238	1416	NA	FT		NUCLEUS		Protein serine/threonine phosphatase, regulates Hsp90 chaperone by affecting its ATPase and cochaperone binding activities; has similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth	protein dephosphorylation	protein serine/threonine phosphatase activity	nucleus|cytoplasm
YPL274W	YPL274W	SAM3	hom	Verified	0.173807357348844	0.431008431038409	no	2073	0.475436470544708	1584	NA	FT		ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p	spermidine transport|putrescine transport|S-adenosylmethionine transport	S-adenosylmethionine transmembrane transporter activity|spermidine transmembrane transporter activity|putrescine transmembrane transporter activity	integral to membrane|plasma membrane
YMR133W	YMR133W	REC114	hom	Verified	0.173471473483188	0.431140424396157	no	2074	0.407228404184135	1330	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division	meiotic DNA double-strand break formation|reciprocal meiotic recombination	molecular_function	condensed nuclear chromosome
YDL176W	YDL176W	YDL176W	hom	Verified	0.172853889929405	0.431383138242733	no	2075	0.421364657922112	1380	NA					Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene	biological_process	molecular_function	cellular_component
YBR089C-A	YBR089C-A	NHP6B	hom	Verified	0.172673286667173	0.431454121251898	no	2076	0.414352237945299	1365	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		High-mobility group (HMG) protein, binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Ap; homologous to mammalian HMGB1 and HMGB2; NHP6B has a paralog, NHP6A, that arose from the whole genome duplication	RNA polymerase III transcriptional preinitiation complex assembly|chromatin remodeling|transcription from RNA polymerase II promoter	nucleosome binding|DNA binding, bending|sequence-specific DNA binding	nucleus
YBR158W	YBR158W	AMN1	hom	Verified	0.172616442786787	0.431476463220537	no	2077	0.451343807577515	1502	NA	FT	CELL CYCLE|CELL DIVISION	NUCLEUS		Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)	mitotic cell cycle checkpoint|negative regulation of exit from mitosis	protein binding	nucleus|cellular bud|cytoplasm
YPL079W	YPL079W	RPL21B	hom	Verified	0.172058378954554	0.431695816748924	no	2078	0.420318877042357	1402	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L21B; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21B has a paralog, RPL21A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YDR316W	YDR316W	OMS1	hom	Verified	0.171837034039428	0.431782824799067	no	2079	0.443396622692457	1454	NA	FT		MITOCHONDRION		Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif; multicopy suppressor of respiratory defects caused by OXA1 mutations	biological_process	S-adenosylmethionine-dependent methyltransferase activity	mitochondrial envelope|mitochondrion
YKL179C	YKL179C	COY1	hom	Verified	0.17151618781946	0.431908951501439	no	2080	0.372249830780108	1239	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function	Golgi vesicle transport	molecular_function	Golgi membrane
YDR438W	YDR438W	THI74	hom	Verified	0.16823832310507	0.433197896560023	no	2081	0.437126372340547	1432	NA	FT		MITOCHONDRION		Mitochondrial transporter repressible by thiamine; THI74 has a paralog, YML018C, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrion|integral to membrane
YIL039W	YIL039W	TED1	hom	Verified	0.167335912058787	0.433552874375916	no	2082	0.447974868347093	1453	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)	ER to Golgi vesicle-mediated transport	molecular_function	endoplasmic reticulum
YEL023C_p	YEL023C	YEL023C	hom	Uncharacterized	0.166562048751851	0.433857328590574	no	2083	0.440028108006264	1454	NA					Putative protein of unknown function; expression is increased greatly during sporulation; YEL023C is not an essential gene	biological_process	molecular_function	cellular_component
YGL006W-A_p	YGL006W-A	YGL006W-A	hom	Uncharacterized	0.166279997587183	0.433968303260297	no	2084	0.42696902395887	1408	NA					Putative protein of unknown function; identified by SAGE	biological_process	molecular_function	cellular_component
YER027C	YER027C	GAL83	hom	Verified	0.165216885973369	0.434386637412241	no	2085	0.424666879299326	1383	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|SIGNALING|PROTEIN PHOSPHORYLATION	ENDOMEMBRANE SYSTEM|NUCLEUS		One of three possible beta-subunits of the Snf1 kinase complex, allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source; contains glycogen-binding domain	signal transduction|cell adhesion|protein phosphorylation|invasive growth in response to glucose limitation|regulation of protein complex assembly	AMP-activated protein kinase activity	AMP-activated protein kinase complex|nucleus|nuclear envelope lumen|cytoplasm
YBL046W	YBL046W	PSY4	hom	Verified	0.164870099853294	0.434523113580231	no	2086	0.432638178081609	1433	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS		Regulatory subunit of protein phosphatase PP4; presence of Psy4p in the PP4 complex (along with catalytic subunit Pph3p and Psy2p) is required for dephosphorylation of the histone variant H2AX, but not for dephosphorylation of Rad53p, during recovery from the DNA damage checkpoint; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; required for cisplatin resistance; homolog of mammalian R2	Unknown|protein dephosphorylation	protein phosphatase regulator activity	nucleus|cytoplasm
YPR095C	YPR095C	SYT1	hom	Verified	0.16358772644968	0.435027853705657	no	2087	0.444244860513896	1460	NA	FT	VESICLE-MEDIATED TRANSPORT|SIGNALING	MITOCHONDRION|GOLGI APPARATUS		Guanine nucleotide exchange factor (GEF) for Arf proteins; promotes activation of Arl1p, which recruits Imh1p to the Golgi; involved in vesicular transport; member of the Sec7-domain family; contains a PH domain	vesicle-mediated transport|exocytosis|positive regulation of ARF protein signal transduction	ARF guanyl-nucleotide exchange factor activity	mitochondrion|Golgi apparatus part
YAL068C	YAL068C	PAU8	hom	Verified	0.163204282606868	0.43517879719295	no	2088	0.429292683688443	1419	NA	FT	TRANSCRIPTION FROM RNA POL II			Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions	ascospore formation|positive regulation of transcription from RNA polymerase II promoter	molecular_function	cellular_component
YOL070C	YOL070C	NBA1	hom	Verified	0.162791471920885	0.435341311559322	no	2089	0.443284474015299	1454	NA	FT		SITE OF POLARIZED GROWTH		Protein of unknown function, localizes to the bud neck and cytoplasm; interacts with Nap1p; may interact with ribosomes, based on co-purification experiments; potential Cdc28p substrate	biological_process	molecular_function	ribosome|cellular bud neck|cytoplasm
YNR055C	YNR055C	HOL1	hom	Verified	0.162654726464593	0.435395147607157	no	2090	0.427020928446376	1416	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION|PLASMA MEMBRANE		Putative transporter in the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; mutations in membrane-spanning domains permit cation and histidinol uptake	organic alcohol transport|cation transport	alcohol transmembrane transporter activity|inorganic cation transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YNL324W_d	YNL324W	YNL324W	hom	Dubious	0.162552724017285	0.435435306274328	no	2091	0.443240916727459	1445	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKL204W	YKL204W	EAP1	hom	Verified	0.161795669837589	0.435733381542072	no	2092	0.449547157113554	1480	NA	FT	TRANSLATION			eIF4E-associated protein, competes with eIF4G for binding to eIF4E; accelerates mRNA degradation by promoting decapping, facilitated by interaction with eIF4E; essential for Puf5p mediated repression; associates with Puf5p and Dhh1p; inhibits cap-dependent translation; functions independently of eIF4E to maintain genetic stability; plays a role in cell growth, implicated in the TOR signaling cascade	negative regulation of translation	eukaryotic initiation factor 4E binding	mRNA cap binding complex|cytoplasmic stress granule
YNL219C	YNL219C	ALG9	hom	Verified	0.161585663837772	0.435816073770951	no	2093	0.442699436825892	1454	NA	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Mannosyltransferase, involved in N-linked glycosylation; catalyzes both the transfer of seventh mannose residue on B-arm and ninth mannose residue on the C-arm from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation	dolichol-linked oligosaccharide biosynthetic process|protein glycosylation	mannosyltransferase activity	integral to membrane|endoplasmic reticulum
YJR146W_p	YJR146W	YJR146W	hom	Uncharacterized	0.160594306909321	0.436206469562516	no	2094	0.437085118124207	1437	NA					Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps HMS2	biological_process	molecular_function	cellular_component
YGR069W_d	YGR069W	YGR069W	hom	Dubious	0.160235365530185	0.436347835819185	no	2095	0.442304170957308	1453	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGL139W	YGL139W	FLC3	hom	Verified	0.158908791176617	0.436870367176321	no	2096	0.435503798239981	1425	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER	FAD transport|transmembrane transport	FAD transmembrane transporter activity	mitochondrion|integral to membrane|endoplasmic reticulum
YMR183C	YMR183C	SSO2	hom	Verified	0.158210822003228	0.437145338215065	no	2097	0.427116024747732	1422	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p	Golgi to plasma membrane transport|ascospore-type prospore assembly|vesicle fusion	phosphatidic acid binding|SNAP receptor activity	endoplasmic reticulum|plasma membrane|prospore membrane|cytoplasm
YLL056C_p	YLL056C	YLL056C	hom	Uncharacterized	0.15749191434311	0.437428589897557	no	2098	0.404744919792262	1305	NA					Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p and genes involved in pleiotropic drug resistance (PDR); expression is induced in cells treated with the mycotoxin patulin	biological_process	molecular_function	cellular_component
YKR099W	YKR099W	BAS1	hom	Verified	0.157187974942045	0.437548352548686	no	2099	0.441369890070769	1389	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes	positive regulation of transcription from RNA polymerase II promoter	core promoter sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|RNA polymerase II transcription factor recruiting transcription factor activity	nucleus
YIL072W	YIL072W	HOP1	hom	Verified	0.156708060066199	0.437737467277854	no	2100	0.444580849189109	1461	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Meiosis-specific protein required for chromosome synapsis; displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex; required for chiasma formation; in vitro, displays the ability to promote intra- and intermolecular synapsis between double-stranded DNA molecules and to fold DNA into rigid protein?DNA filaments	synaptonemal complex assembly|meiotic recombination checkpoint|synapsis	four-way junction DNA binding	condensed nuclear chromosome|lateral element
YCR083W	YCR083W	TRX3	hom	Verified	0.155145771872172	0.438353199141578	no	2101	0.411954608899303	1375	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		Mitochondrial thioredoxin, highly conserved oxidoreductase required to maintain the redox homeostasis of the cell, forms the mitochondrial thioredoxin system with Trr2p, redox state is maintained by both Trr2p and Glr1p	cellular response to oxidative stress	disulfide oxidoreductase activity	mitochondrion
YMR105C	YMR105C	PGM2	hom	Verified	0.154730203339661	0.438517008959865	no	2102	0.437864997736573	1434	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY			Phosphoglucomutase; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase; protein abundance increases in response to DNA replication stress	glucose 6-phosphate metabolic process|cellular calcium ion homeostasis|galactose catabolic process|cellular cation homeostasis|glucose 1-phosphate metabolic process|trehalose biosynthetic process|UDP-glucose metabolic process|glycogen biosynthetic process	phosphoglucomutase activity	cytoplasm
YCR106W	YCR106W	RDS1	hom	Verified	0.154247169597026	0.438707425614799	no	2103	0.427243670148092	1377	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Putative zinc cluster transcription factor; involved in conferring resistance to cycloheximide	response to xenobiotic stimulus	sequence-specific DNA binding|DNA binding	nucleus
YBR196C-B_p	YBR196C-B	YBR196C-B	hom	Uncharacterized	0.153019491569082	0.439191452129398	no	2104	0.437684698431567	1434	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YGR288W	YGR288W	MAL13	hom	Verified	0.152637656603559	0.439342013632946	no	2105	0.447107094883837	1476	NA	FT	TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM	NUCLEUS		MAL-activator protein, part of complex locus MAL1; nonfunctional in genomic reference strain S288C	cellular carbohydrate metabolic process|regulation of transcription, DNA-dependent	sequence-specific DNA binding transcription factor activity	nucleus
YJL192C	YJL192C	SOP4	hom	Verified	0.151487611552867	0.439795541304624	no	2106	0.493298259225484	1710	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		ER-membrane protein; suppressor of pma1-7, deletion of SOP4 slows down the export of wild-type Pma1p and Pma1-7 from the ER	ER to Golgi vesicle-mediated transport	molecular_function	integral to membrane|endoplasmic reticulum
YBR239C_p	YBR239C	ERT1	hom	Uncharacterized	0.150000943766931	0.440381935333236	no	2107	0.452293737094717	1504	NA	FT	TRANSCRIPTION FROM RNA POL II|SIGNALING|CARBOHYDRATE METABOLISM	NUCLEUS		Transcriptional regulator of nonfermentable carbon utilization; GFP-fusion protein localizes to cytoplasm, nucleus; null mutation affects periodicity of transcriptional and metabolic oscillation; plays role in restricting Ty1 transposition	biological_process	sequence-specific DNA binding	nucleus|cytoplasm
YJL170C	YJL170C	ASG7	hom	Verified	0.149561020249217	0.440555481763999	no	2108	0.444507355486494	1474	NA	FT		ENDOMEMBRANE SYSTEM|PLASMA MEMBRANE		Protein that regulates signaling from a G protein beta subunit Ste4p and its relocalization within the cell; specific to a-cells and induced by alpha-factor	conjugation with cellular fusion	molecular_function	plasma membrane
YKL040C	YKL040C	NFU1	hom	Verified	0.149347663106835	0.440639653623164	no	2109	0.432574519708518	1421	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS|COFACTOR METABOLISM	MITOCHONDRION		Protein involved in iron metabolism in mitochondria; similar to NifU, which is a protein required for the maturation of the Fe/S clusters of nitrogenase in nitrogen-fixing bacteria	cellular iron ion homeostasis|iron-sulfur cluster assembly|intracellular sequestering of iron ion	molecular_function	mitochondrion|mitochondrial matrix
YPL032C	YPL032C	SVL3	hom	Verified	0.148748407084762	0.440876081385451	no	2110	0.464207942642519	1545	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS	SITE OF POLARIZED GROWTH		Protein of unknown function; mutant phenotype suggests a potential role in vacuolar function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; relocalizes from bud neck to cytoplasm upon DNA replication stress	endocytosis	molecular_function	cellular bud|cellular bud neck|cytoplasm
YBR057C	YBR057C	MUM2	hom	Verified	0.148690588290944	0.440898894067181	no	2111	0.453375423759596	1521	NA	FT	CELL CYCLE			Cytoplasmic protein essential for meiotic DNA replication and sporulation; interacts with Orc2p, which is a component of the origin recognition complex	premeiotic DNA replication	molecular_function	cytoplasm
YMR085W_p	YMR085W	YMR085W	hom	Uncharacterized	0.148683458189825	0.440901707296276	no	2112	0.45541164233939	1521	NA	FT	CARBOHYDRATE METABOLISM			Putative protein of unknown function; YMR085W and adjacent ORF YMR084W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1	biological_process	molecular_function	cellular_component
YLR205C	YLR205C	HMX1	hom	Verified	0.147549228138333	0.441349263229255	no	2113	0.428630692831029	1410	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants	response to oxidative stress|cellular iron ion homeostasis|heme catabolic process	heme oxygenase (decyclizing) activity	endoplasmic reticulum|membrane|nuclear outer membrane
YLR199C	YLR199C	PBA1	hom	Verified	0.147168803543702	0.441499391805869	no	2114	0.430750889446053	1430	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS			Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly	proteasome assembly	molecular_function	cytoplasm
YDL078C	YDL078C	MDH3	hom	Verified	0.14683787562469	0.441629994135649	no	2115	0.416980852298687	1377	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM			Peroxisomal malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle	glyoxylate cycle|fatty acid beta-oxidation|malate metabolic process|NADH regeneration	L-malate dehydrogenase activity|mRNA binding	peroxisomal matrix|peroxisome
YBR085C-A	YBR085C-A	YBR085C-A	hom	Verified	0.14660065249783	0.441723619314775	no	2116	0.442257855632613	1473	NA	FT		NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YPR135W	YPR135W	CTF4	hom	Verified	0.146297379125561	0.441843317376947	no	2117	0.48599454990349	1740	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Chromatin-associated protein, required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion	DNA repair|replicative cell aging|double-strand break repair via break-induced replication|DNA replication initiation|DNA-dependent DNA replication|mitotic sister chromatid cohesion	chromatin binding|DNA binding	nuclear chromosome|replication fork protection complex|nuclear replication fork|nucleus
YBR144C_d	YBR144C	YBR144C	hom	Dubious	0.144520982010296	0.442544544562748	no	2118	0.433297164857855	1434	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR144C is not an essential gene	Unknown	Unknown	Unknown
YGR110W	YGR110W	CLD1	hom	Verified	0.144333318750323	0.442618634598345	no	2119	0.452178561192921	1507	NA	FT	LIPID METABOLISM	MITOCHONDRION		Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58	cardiolipin acyl-chain remodeling|cardiolipin metabolic process	phospholipase A2 activity	mitochondrion
YGL062W	YGL062W	PYC1	hom	Verified	0.143783590506218	0.442835680549973	no	2120	0.444761685912851	1472	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc2p; mutations in the human homolog are associated with lactic acidosis; PYC1 has a paralog, PYC2, that arose from the whole genome duplication	NADPH regeneration|gluconeogenesis	pyruvate carboxylase activity	cytosol
YGL126W	YGL126W	SCS3	hom	Verified	0.142469952657609	0.443354405774868	no	2121	0.447372679467058	1478	NA	FT	LIPID METABOLISM	ENDOPLASMIC RETICULUM		Protein required for inositol prototrophy; required for normal ER membrane biosynthesis; ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; disputed role in the synthesis of inositol phospholipids from inositol	phospholipid metabolic process	molecular_function	integral to membrane|endoplasmic reticulum
YPL144W	YPL144W	POC4	hom	Verified	0.142197421287303	0.443462034303913	no	2122	0.432454173563196	1430	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS			Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions	proteasome assembly|chaperone-mediated protein complex assembly	molecular_function	intracellular|cytoplasm
YDL066W	YDL066W	IDP1	hom	Verified	0.141842353409185	0.443602264539902	no	2123	0.482438988687268	1761	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes	isocitrate metabolic process|glutamate biosynthetic process	isocitrate dehydrogenase (NADP+) activity	mitochondrial nucleoid|mitochondrion
YDR430C	YDR430C	CYM1	hom	Verified	0.14160129248785	0.443697472981874	no	2124	0.43760325671493	1441	NA	FT	PROTEOLYSIS	MITOCHONDRION		Lysine-specific metalloprotease of the mitochondrial intermembrane space, member of the pitrilysin family; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology	proteolysis|proteolysis involved in cellular protein catabolic process	metalloendopeptidase activity	mitochondrion|mitochondrial intermembrane space
YNL098C	YNL098C	RAS2	hom	Verified	0.141066258276169	0.443908799523745	no	2125	0.484358892576481	1625	NA	FT	PROTEIN LOCALIZATION|SIGNALING|NUCLEOTIDE METABOLISM|RESPONSE TO NUTRIENT LEVELS	PLASMA MEMBRANE		GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes	pseudohyphal growth|ascospore formation|activation of adenylate cyclase activity|regulation of protein localization|replicative cell aging|positive regulation of transcription by galactose|Ras protein signal transduction	GTP binding|GTPase activity	plasma membrane
YGL038C	YGL038C	OCH1	hom	Verified	0.140819634368312	0.444006215823302	no	2126	0.457592204838374	1846	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Mannosyltransferase of the cis-Golgi apparatus, initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins	protein N-linked glycosylation	alpha-1,6-mannosyltransferase activity|transferase activity, transferring glycosyl groups	Golgi cis cisterna
YOR280C	YOR280C	FSH3	hom	Verified	0.140765057584449	0.44402777407845	no	2127	0.443874801485955	1462	NA					Putative serine hydrolase; likely target of Cyc8p-Tup1p-Rfx1p transcriptional regulation; sequence is similar to S. cerevisiae Fsh1p and Fsh2p and the human candidate tumor suppressor OVCA2	biological_process	molecular_function	cellular_component
YIL001W_p	YIL001W	YIL001W	hom	Uncharacterized	0.140627874886365	0.444081963044987	no	2128	0.448507672600959	1477	NA					Putative protein of unknown function; contains a BTB/POZ domain which generally function in protein interactions; deletion slightly improved competitive fitness in rich media; GFP-tagged protein is localized to the cytoplasm	biological_process	molecular_function	cytoplasm
YDR318W	YDR318W	MCM21	hom	Verified	0.139068939838786	0.444697836051677	no	2129	0.451697414360808	1503	NA	FT	CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME	KINETOCHORE	Component of the kinetochore sub-complex COMA; COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) bridges kinetochore subunits in contact with centromeric DNA with subunits bound to microtubules during kinetochore assembly; involved in minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-O and fission yeast mal2	chromosome segregation|establishment of mitotic sister chromatid cohesion	molecular_function	COMA complex|condensed nuclear chromosome kinetochore
YLR406C-A_p	YLR406C-A	YLR406C-A	hom	Uncharacterized	0.138821690148855	0.444795526841091	no	2130	0.442927541425953	1472	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YHR157W	YHR157W	REC104	hom	Verified	0.138524929381504	0.444912784372246	no	2131	0.434347107488977	1426	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Protein involved in early stages of meiotic recombination; required for meiotic crossing over; forms a complex with Rec102p and Spo11p necessary during the initiation of recombination	meiotic DNA double-strand break formation|reciprocal meiotic recombination	molecular_function	condensed nuclear chromosome
YML021C	YML021C	UNG1	hom	Verified	0.138233998002398	0.445027743247058	no	2132	0.451294565040703	1487	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION		Uracil-DNA glycosylase, required for repair of uracil in DNA formed by spontaneous cytosine deamination, not required for strand-specific mismatch repair, cell-cycle regulated, expressed in late G1, localizes to mitochondria and nucleus	DNA repair	uracil DNA N-glycosylase activity	mitochondrion|nucleus
YDR252W	YDR252W	BTT1	hom	Verified	0.13779876527326	0.445199730110024	no	2133	0.449002723866993	1490	NA	FT	PROTEIN LOCALIZATION	NUCLEUS		Beta3 subunit of the heterotrimeric nascent polypeptide-associated complex which binds ribosomes via its beta-subunits in close proximity to nascent polypeptides; interacts with Caf130p of the CCR4-NOT complex; similar to human BTF3	'de novo' cotranslational protein folding	unfolded protein binding	nascent polypeptide-associated complex|CCR4-NOT complex
YNL217W_p	YNL217W	YNL217W	hom	Uncharacterized	0.135857863654102	0.445966823240078	no	2134	0.447472389421624	1479	NA					Putative protein of unknown function; weak sequence similarity to bis (5'-nucleotidyl)-tetraphosphatases; (GFP)-fusion protein localizes to the vacuole; null mutant is highly sensitive to azaserine and resistant to sodium-O-vandate	biological_process	phosphatase activity	fungal-type vacuole
YGL063W	YGL063W	PUS2	hom	Verified	0.135087928229426	0.446271177282517	no	2135	0.436684498173211	1418	NA	FT	RNA PROCESSING	MITOCHONDRION		Mitochondrial tRNA:pseudouridine synthase; acts at positions 27 and 28, but not at position 72; efficiently and rapidly targeted to mitochondria, specifically dedicated to mitochondrial tRNA modification	tRNA pseudouridine synthesis	pseudouridine synthase activity	mitochondrion
YJR096W	YJR096W	YJR096W	hom	Verified	0.1343152269342	0.446576656496218	no	2136	0.45608150197008	1517	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Putative xylose and arabinose reductase; member of the aldo-keto reductase (AKR) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS	cellular response to oxidative stress|D-xylose catabolic process|arabinose catabolic process	alditol:NADP+ 1-oxidoreductase activity|aldo-keto reductase (NADP) activity	nucleus|cytoplasm
YKL093W	YKL093W	MBR1	hom	Verified	0.133986559232722	0.446706601387292	no	2137	0.441091179872523	1460	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants	aerobic respiration	molecular_function	cellular_component
YDL160C-A	YDL160C-A	MHF2	hom	Verified	0.133859964405017	0.446756654535227	no	2138	0.453719464595031	1495	NA	FT	RESPONSE TO DNA DAMAGE			Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM to stabilize and remodel blocked replication forks and repair damaged DNA; mhf2 srs2 double mutants are MMS hypersensitive; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-X, also known as MHF2	response to DNA damage stimulus	molecular_function	cellular_component
YBR271W	YBR271W	EFM2	hom	Verified	0.132960518643006	0.44711230237995	no	2139	0.482206346428129	1586	NA					S-adenosylmethionine-dependent methyltransferase; methylates translation elongation factors EF2 (Eft1p and Eft2p) and EF3A (Yef3p); belongs to the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; predicted to be involved in ribosome biogenesis	peptidyl-lysine methylation	S-adenosylmethionine-dependent methyltransferase activity|protein-lysine N-methyltransferase activity	cytoplasm
YKL072W	YKL072W	STB6	hom	Verified	0.13250903347385	0.447290839176381	no	2140	0.414981632739361	1352	NA					Protein that binds Sin3p in a two-hybrid assay	biological_process	molecular_function	cellular_component
YCL026C-B	YCL026C-B	HBN1	hom	Verified	0.13177619659934	0.447580657350796	no	2141	0.452199122484126	1536	NA	FT	OXIDATION-REDUCTION PROCESS	NUCLEUS		Protein of unknown function; similar to bacterial nitroreductases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein becomes insoluble upon intracellular iron depletion; protein abundance increases in response to DNA replication stress	biological_process	NAD(P)H nitroreductase activity	nucleus|cytoplasm
YOR154W_p	YOR154W	SLP1	hom	Uncharacterized	0.131269486633292	0.447781064513012	no	2142	0.432313567167387	1428	NA					Glycosylated integral ER membrane protein of unknown function; forms an ER-membrane associated protein complex with Emp65p; member of the SUN-like family of proteins; genetic interactions suggest a role in folding of ER membrane proteins; required for nuclear envelope localization of Mps3p	protein folding in endoplasmic reticulum	molecular_function	cellular_component
YPR089W_p	YPR089W	YPR089W	hom	Uncharacterized	0.131266604721396	0.44778220436651	no	2143	0.449137395979285	1474	NA	FT		GOLGI APPARATUS		Protein of unknown function; exhibits genetic interaction with ERG11 and protein-protein interaction with Hsp82p	biological_process	molecular_function	cellular_component
YDR089W	YDR089W	YDR089W	hom	Verified	0.131175209657827	0.447818353156319	no	2144	0.439774905190464	1462	NA	FT	MEMBRANE ORGANIZATION			Protein of unknown function; deletion confers resistance to nickel; contains an SPX domain, which is found in proteins involved in phosphate homeostasis; relocalizes from vacuole to cytoplasm upon DNA replication stress	cellular membrane organization	molecular_function	integral to membrane|membrane
YCL030C	YCL030C	HIS4	hom	Verified	0.129833620629365	0.448349031310283	no	2145	0.456247767903527	1506	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS			Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase, phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis	histidine biosynthetic process	phosphoribosyl-ATP diphosphatase activity|phosphoribosyl-AMP cyclohydrolase activity|histidinol dehydrogenase activity	intracellular
YGR055W	YGR055W	MUP1	hom	Verified	0.128521177343962	0.448868270050818	no	2146	0.448546126320297	1485	NA	FT		PLASMA MEMBRANE		High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake	cysteine transport|sulfur amino acid transport|methionine transport	L-methionine secondary active transmembrane transporter activity	integral to membrane|integral to plasma membrane
YOR290C	YOR290C	SNF2	hom	Verified	0.127273139927425	0.449362109316457	no	2147	0.480556804715497	1606	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS	NUCLEUS	RSC COMPLEX	Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p	cellular alcohol catabolic process|ATP-dependent chromatin remodeling|double-strand break repair|strand invasion|positive regulation of mating type switching|sucrose catabolic process|positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation|nucleosome mobilization|chromatin remodeling|DNA-dependent DNA replication|positive regulation of transcription from RNA polymerase II promoter	histone acetyl-lysine binding|RNA polymerase II activating transcription factor binding|DNA-dependent ATPase activity|nucleosom