strainid	orf	gene	zyg	qualifier	SGTC_182|3448-4371.score	SGTC_182|3448-4371.expt.zyg.pval	SGTC_182|3448-4371.expt.zyg.significant	SGTC_182|3448-4371.expt.zyg.rank	strain.pval	strain.rank	clearance	Fclass	Fterms.BP	Fterms.CC	Fterms.complex	description	GO_process	GO_function	GO_component
YGR119C	YGR119C	NUP57	het	Verified	5.71181153590495	5.58899200865622e-09	yes	1	1.36765235760071e-06	9	1.280	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup49p)	NLS-bearing substrate import into nucleus|protein import into nucleus|nuclear pore organization|protein targeting to nuclear inner membrane	nucleocytoplasmic transporter activity|structural constituent of nuclear pore	nuclear pore central transport channel|integral to membrane|nuclear pore
YNL256W	YNL256W	FOL1	het	Verified	4.43226654688349	4.66238209269712e-06	yes	2	2.03850985675727e-07	8	0.604	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Multifunctional enzyme of the folic acid biosynthesis pathway, has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities	tetrahydrofolate biosynthetic process	dihydroneopterin aldolase activity|2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity|dihydropteroate synthase activity	mitochondrial envelope|mitochondrion|cytoplasm
YLR141W	YLR141W	RRN5	het	Verified	3.8286637969691	6.44204347166059e-05	yes	3	1.38893463046564e-05	9	0.441	FT	CHROMATIN ORGANIZATION	NUCLEUS		Protein involved in transcription of rDNA by RNA polymerase I; transcription factor, member of UAF (upstream activation factor) family along with Rrn9p and Rrn10p	transcription of nuclear large rRNA transcript from RNA polymerase I promoter|chromatin organization	RNA polymerase I upstream control element sequence-specific DNA binding transcription factor activity	nucleolus|RNA polymerase I upstream activating factor complex
YDR167W	YDR167W	TAF10	het	Verified	3.38731793063413	0.000352897729581735	yes	4	0.00138403326878467	37	0.007	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS	RNA POL II, HOLOENZYME|HISTONE ACETYLTRANSFERASE	Subunit (145 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification	histone acetylation|RNA polymerase II transcriptional preinitiation complex assembly|chromatin modification|transcription from RNA polymerase II promoter	chromatin binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly|protein complex scaffold	SLIK (SAGA-like) complex|SAGA complex|transcription factor TFIID complex
YML077W	YML077W	BET5	het	Verified	3.37999012340353	0.000362442173131938	yes	5	0.000123076999721226	8	0.055	FT	VESICLE-MEDIATED TRANSPORT	ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Component of the TRAPP (transport protein particle) complex, which plays an essential role in the vesicular transport from endoplasmic reticulum to Golgi	ER to Golgi vesicle-mediated transport	Rab guanyl-nucleotide exchange factor activity	TRAPP complex
YKL186C	YKL186C	MTR2	het	Verified	3.32450273191086	0.000442881828236844	yes	6	0.000578188328045478	33	0.044	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	mRNA transport regulator, essential nuclear protein; Mex67p and Mtr2p form a mRNA export complex which binds to RNA	poly(A)+ mRNA export from nucleus|ribosomal large subunit export from nucleus	protein binding	integral to membrane|nuclear RNA export factor complex|nuclear pore
YDR280W	YDR280W	RRP45	het	Verified	3.2805187147528	0.000518081951488104	yes	7	0.00502293349747297	91	0.170	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress	U5 snRNA 3'-end processing|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nonfunctional rRNA decay|nuclear polyadenylation-dependent mRNA catabolic process|U4 snRNA 3'-end processing|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|polyadenylation-dependent snoRNA 3'-end processing|U1 snRNA 3'-end processing|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|nuclear-transcribed mRNA catabolic process, non-stop decay	molecular_function	nucleolus|nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)
YBR243C	YBR243C	ALG7	het	Verified	3.11040701352998	0.000934148546394868	yes	8	0.000143311788693004	20	0.052	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin	protein N-linked glycosylation|aerobic respiration	UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity	UDP-N-acetylglucosamine transferase complex|integral to membrane
YER023W	YER023W	PRO3	het	Verified	3.05824253549742	0.00111319651378892	no	9	0.000168716558030408	20	0.179	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS			Delta 1-pyrroline-5-carboxylate reductase, catalyzes the last step in proline biosynthesis	proline biosynthetic process	pyrroline-5-carboxylate reductase activity	cytoplasm
YOL022C	YOL022C	TSR4	het	Verified	2.87954261672876	0.00199126234666189	no	10	0.000425620379512165	25	0.055	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS			Cytoplasmic protein required for correct processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; essential gene in S288C background but not in CEN.PK2	maturation of SSU-rRNA	molecular_function	cytoplasm
YML130C	YML130C	ERO1	het	Verified	2.824922583257	0.00236460204583674	no	11	0.000691840182156078	22	0.113	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds	protein folding|protein thiol-disulfide exchange	thiol oxidase activity	endoplasmic reticulum
YEL058W	YEL058W	PCM1	het	Verified	2.71233315889418	0.00334057025852482	no	12	0.000281969124943803	27	0.003	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	NUCLEUS		Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors	fungal-type cell wall chitin biosynthetic process	phosphoacetylglucosamine mutase activity	nucleus|cytoplasm
YER172C	YER172C	BRR2	het	Verified	2.70943289399252	0.00336991688673678	no	13	0.000632428237974591	18	0.016	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING	NUCLEUS		RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)	ATP-dependent RNA helicase activity	U4/U6 x U5 tri-snRNP complex|U5 snRNP
YDR021W	YDR021W	FAL1	het	Verified	2.69305877435451	0.00353998934575628	no	14	0.000939817560884924	25	0.045	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Nucleolar protein required for maturation of 18S rRNA, member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	ATP-dependent RNA helicase activity	nucleolus|FAl1-SGD1 complex
YDR037W	YDR037W	KRS1	het	Verified	2.64775490758774	0.00405141232284343	no	15	0.000379752023710966	24	0.028	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION			Lysyl-tRNA synthetase	lysyl-tRNA aminoacylation	lysine-tRNA ligase activity	cytoplasm
YGL172W	YGL172W	NUP49	het	Verified	2.61971641390359	0.00440014573433233	no	16	0.0131587252019244	138	0.034	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup57p)	poly(A)+ mRNA export from nucleus|ribosomal large subunit export from nucleus|protein import into nucleus|tRNA export from nucleus	nucleocytoplasmic transporter activity|structural constituent of nuclear pore	nuclear pore central transport channel|nuclear envelope|integral to membrane|nuclear pore
YGR091W	YGR091W	PRP31	het	Verified	2.58543974483439	0.0048627435061037	no	17	0.0027493635863695	53	0.039	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING	NUCLEUS|MITOCHONDRION		Splicing factor, component of the U4/U6-U5 snRNP complex	mRNA splicing, via spliceosome|spliceosomal snRNP assembly	molecular_function	mitochondrion|U4/U6 x U5 tri-snRNP complex
YDR361C	YDR361C	BCP1	het	Verified	2.54667629190745	0.00543771319867917	no	18	0.00545201787311415	75	0.016	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS	NUCLEUS		Essential protein involved in nuclear export of Mss4p, which is a lipid kinase that generates phosphatidylinositol 4,5-biphosphate and plays a role in actin cytoskeleton organization and vesicular transport	protein export from nucleus|ribosomal large subunit export from nucleus	molecular_function	nucleus|cytoplasm
YER168C	YER168C	CCA1	het	Verified	2.53105636069697	0.00568597869805207	no	19	0.00472989004114007	66	0.015	FT	RNA PROCESSING	NUCLEUS|MITOCHONDRION		ATP (CTP):tRNA-specific tRNA nucleotidyltransferase; different forms targeted to the nucleus, cytosol, and mitochondrion are generated via the use of multiple transcriptional and translational start sites	tRNA 3'-terminal CCA addition	tRNA adenylyltransferase activity	mitochondrion|nucleus|mitochondrial matrix|cytoplasm
YDR353W	YDR353W	TRR1	het	Verified	2.51599509477539	0.0059348417396488	no	20	0.00620532804405977	100	0.029	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS			Cytoplasmic thioredoxin reductase; key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress; protein abundance increases in response to DNA replication stress; TRR1 has a paralog, TRR2, that arose from the whole genome duplication	cellular response to oxidative stress|cell redox homeostasis	ferrous iron binding|thioredoxin-disulfide reductase activity	cytosol
YLR196W	YLR196W	PWP1	het	Verified	2.48661462751854	0.00644825077243764	no	21	0.00220924206277952	40	0.004	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily	rRNA processing	molecular_function	nucleolus|nucleus|cytoplasm
YKL122C	YKL122C	SRP21	het	Verified	2.48293229859854	0.00651529251833042	no	22	0.0031041419912282	39	0.004	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION	NUCLEUS		Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm	SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition|protein targeting to ER	signal sequence binding	nucleus|signal recognition particle, endoplasmic reticulum targeting
YER127W	YER127W	LCP5	het	Verified	2.47927870337721	0.00658241969872511	no	23	0.00620926883806687	83	0.021	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus	rRNA modification|rRNA processing	RNA binding	small nuclear ribonucleoprotein complex|small nucleolar ribonucleoprotein complex
YBR256C	YBR256C	RIB5	het	Verified	2.45781807474417	0.00698919825323027	no	24	0.00600763802789372	73	0.107	FT	OXIDATION-REDUCTION PROCESS			Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway	riboflavin biosynthetic process	riboflavin synthase activity	cellular_component
YBL040C	YBL040C	ERD2	het	Verified	2.35114756361852	0.00935780501609378	no	25	0.00517497917445993	50	0.046	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		HDEL receptor, an integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteins	protein retention in ER lumen|ER to Golgi vesicle-mediated transport	HDEL sequence binding	integral to endoplasmic reticulum membrane|integral to membrane
YMR128W	YMR128W	ECM16	het	Verified	2.30512921035119	0.0105796689955441	no	26	0.00781490925846194	86	0.048	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS|MITOCHONDRION		Essential DEAH-box ATP-dependent RNA helicase specific to the U3 snoRNP, predominantly nucleolar in distribution, required for 18S rRNA synthesis	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosome biogenesis	RNA helicase activity	small-subunit processome|mitochondrion|nucleolus|90S preribosome
YGR251W	YGR251W	NOP19	het	Verified	2.25673973512636	0.0120121712028878	no	27	0.00611930474649748	78	0.044	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Ribosome biogenesis factor; nucleolar protein associated with pre-rRNA components of the 90S preribosome, required for cleavage of pre-rRNA at A0, A1 and A2 sites; interacts with RNA helicase Dhr2p and RNA helicase-like protein Utp25p; required for incorporation of Utp25p into preribosomes	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	nucleoplasm|nucleolus|nucleus|90S preribosome
YNL006W	YNL006W	LST8	het	Verified	2.2126571008644	0.0134606475499495	no	28	0.00703667768844775	83	0.071	FT	SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS|PLASMA MEMBRANE		Protein required for the transport of amino acid permease Gap1p from the Golgi to the cell surface; component of the TOR signaling pathway; associates with both Tor1p and Tor2p; contains a WD-repeat	transport|TOR signaling cascade|fungal-type cell wall organization|signal transduction|regulation of cell growth|establishment or maintenance of actin cytoskeleton polarity|mitochondria-nucleus signaling pathway	protein kinase activator activity|protein binding	TORC1 complex|TORC2 complex|endosome membrane|extrinsic to internal side of plasma membrane|Golgi membrane
YOR169C_d	YOR169C	YOR169C	het	Dubious	2.14127056628166	0.016126112644876	no	29	0.00388410249298835	45	0.033					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GLN4/YOR168W	Unknown	Unknown	Unknown
YJL203W	YJL203W	PRP21	het	Verified	2.10817426247974	0.0175079593422904	no	30	0.0105030615157821	67	0.008	FT	RNA PROCESSING	NUCLEUS		Subunit of the SF3a splicing factor complex, required for spliceosome assembly	mRNA splicing, via spliceosome	RNA binding	U2 snRNP|U2-type prespliceosome
YJR141W_p	YJR141W	YJR141W	het	Uncharacterized	2.10009049014957	0.0178604408587852	no	31	0.00767914188341928	91	0.039					Essential protein of unknown function	biological_process	molecular_function	cellular_component
YDR412W	YDR412W	RRP17	het	Verified	2.06149463626643	0.0196279373296886	no	32	0.00631734928826109	95	0.040	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Component of the pre-60S pre-ribosomal particle; required for cell viability under standard (aerobic) conditions but not under anaerobic conditions; exonuclease required for 5′ end processing of pre-60S ribosomal RNA	rRNA processing	molecular_function	cytoplasm
YJR112W	YJR112W	NNF1	het	Verified	2.02164311563424	0.0216066172188816	no	33	0.0135223338199923	104	0.001	FT	CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME	KINETOCHORE	Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation	chromosome segregation	molecular_function	nuclear MIS12/MIND type complex|kinetochore
YPL169C	YPL169C	MEX67	het	Verified	2.02055318675914	0.0216630195490106	no	34	0.0556523707277817	293	0.007	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Poly(A)RNA binding protein involved in nuclear mRNA export, component of the nuclear pore; ortholog of human TAP	mRNA export from nucleus|ribosomal large subunit export from nucleus	protein binding|RNA binding|structural constituent of nuclear pore	integral to membrane|nuclear RNA export factor complex|nuclear pore|cytoplasm
YAL038W	YAL038W	CDC19	het	Verified	2.01323178301747	0.0220451255377077	no	35	0.0273999156578269	208	0.007	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Pyruvate kinase; functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration; regulated via allosteric activation by fructose bisphosphate; CDC19 has a paralog, PYK2, that arose from the whole genome duplication	pyruvate metabolic process|glycolysis	pyruvate kinase activity	cytosol|plasma membrane
YOR060C	YOR060C	SLD7	het	Verified	2.00654062270358	0.0223992995813714	no	36	0.0113147561323364	66	0.003	FT	CELL CYCLE	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|CYTOSKELETON		Protein with a role in chromosomal DNA replication; interacts with Sld3p and reduces its affinity for Cdc45p; deletion mutant has aberrant mitochondria	regulation of DNA-dependent DNA replication initiation	molecular_function	nuclear envelope|endoplasmic reticulum|DNA replication preinitiation complex|nucleus|spindle pole body|cytoplasm
YBL041W	YBL041W	PRE7	het	Verified	2.00345068495674	0.0225644679063548	no	37	0.0262118768989683	156	0.030	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Beta 6 subunit of the 20S proteasome	proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process	molecular_function	nucleus|proteasome storage granule|endoplasmic reticulum membrane|proteasome core complex, beta-subunit complex
YGR264C	YGR264C	MES1	het	Verified	1.97394198875682	0.0241941698066348	no	38	0.0239172855734334	128	0.014	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION			Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs	methionyl-tRNA aminoacylation	methionine-tRNA ligase activity	methionyl glutamyl tRNA synthetase complex|cytoplasm
YML125C	YML125C	PGA3	het	Verified	1.9600111150411	0.0249972455817976	no	39	0.0144864099538494	117	0.013	FT	PROTEIN LOCALIZATION|OXIDATION-REDUCTION PROCESS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Putative cytochrome b5 reductase, localized to the plasma membrane; may be involved in regulation of lifespan; required for maturation of Gas1p and Pho8p, proposed to be involved in protein trafficking; PGA3 has a paralog, AIM33, that arose from the whole genome duplication	protein transport|chronological cell aging|replicative cell aging	molecular_function	endoplasmic reticulum|plasma membrane
YHR166C	YHR166C	CDC23	het	Verified	1.94687574360645	0.0257748166723872	no	40	0.018701467089051	131	0.024	FT	CELL CYCLE|CELL DIVISION|PROTEOLYSIS	NUCLEUS|CHROMOSOME	UBIQUITIN LIGASE COMPLEX	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination	ubiquitin-protein ligase activity|cyclin binding	anaphase-promoting complex
YOR250C	YOR250C	CLP1	het	Verified	1.92313000974143	0.0272318621772049	no	41	0.0478458147508348	255	0.007	FT	RNA PROCESSING	NUCLEUS		Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation	mRNA 3'-end processing|mRNA cleavage|mRNA polyadenylation	RNA binding	mRNA cleavage factor complex
YHR122W	YHR122W	CIA2	het	Verified	1.91568844598988	0.0277023819839875	no	42	0.0184297779979979	140	0.003	FT	CELL CYCLE|CHROMOSOME SEGREGATION	NUCLEUS		Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human FAM96B	establishment of mitotic sister chromatid cohesion	molecular_function	nucleus|cytoplasm
YGR216C	YGR216C	GPI1	het	Verified	1.91219145027016	0.0279258211690368	no	43	0.00733165487337671	56	0.025	FT	LIPID METABOLISM	ENDOPLASMIC RETICULUM		Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs	GPI anchor biosynthetic process	phosphatidylinositol N-acetylglucosaminyltransferase activity	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|integral to membrane
YJR041C	YJR041C	URB2	het	Verified	1.88695387425422	0.0295832649638318	no	44	0.0161999996621113	96	0.000	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Nucleolar protein required for normal metabolism of the rRNA primary transcript, proposed to be involved in ribosome biogenesis	rRNA metabolic process|ribosome biogenesis	molecular_function	nucleolus
YPL044C_d	YPL044C	YPL044C	het	Dubious	1.88673896407988	0.0295977220822022	no	45	0.021436058143953	120	0.009					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP4/YPL043W	Unknown	Unknown	Unknown
YDR454C	YDR454C	GUK1	het	Verified	1.87783205121038	0.030202072074601	no	46	0.00917788198381609	79	0.008	FT	NUCLEOTIDE METABOLISM	NUCLEUS		Guanylate kinase, converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins	GMP metabolic process	guanylate kinase activity	nucleus|cytoplasm
YMR314W	YMR314W	PRE5	het	Verified	1.87005268919976	0.0307382507240677	no	47	0.0347434651390303	214	0.009	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION		Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress	proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process	molecular_function	mitochondrion|proteasome core complex, alpha-subunit complex|proteasome storage granule|nucleus|nuclear outer membrane-endoplasmic reticulum membrane network
YBL074C	YBL074C	AAR2	het	Verified	1.86120292212947	0.0313577629430235	no	48	0.0305041823562631	174	0.001	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING	NUCLEUS		Component of the U5 snRNP, required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron	assembly of spliceosomal tri-snRNP	molecular_function	U5 snRNP
YOL139C	YOL139C	CDC33	het	Verified	1.86042892946411	0.03141243244322	no	49	0.0234021073800763	139	0.001	FT	CELL CYCLE|TRANSLATION	NUCLEUS	RIBOSOME	mRNA cap binding protein and translation initiation factor eIF4E; the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with translation initiation factor eIF4G (Tif4631p or Tif4632p); protein abundance increases in response to DNA replication stress; mutants are defective for adhesion and pseudohyphal growth	regulation of cell cycle|translational initiation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	phosphatidylinositol-3-phosphate binding|translation initiation factor activity	ribosome|nucleus|eukaryotic translation initiation factor 4F complex|cytoplasmic stress granule|cytoplasm
YJR016C	YJR016C	ILV3	het	Verified	1.85987166908326	0.0314518422438172	no	50	0.0215717864465506	112	0.001	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids	branched-chain amino acid biosynthetic process	dihydroxy-acid dehydratase activity	mitochondrion
YFR042W	YFR042W	KEG1	het	Verified	1.85860673354235	0.0315414509847966	no	51	0.0238048278707852	114	0.001	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Integral membrane protein of the ER; physically interacts with Kre6p; has a role in the synthesis of beta-1,6-glucan in the cell wall; required for cell viability	chromosome organization|(1->6)-beta-D-glucan biosynthetic process	molecular_function	integral to endoplasmic reticulum membrane|integral to membrane
YGL097W	YGL097W	SRM1	het	Verified	1.8573633525249	0.0316297383483944	no	52	0.0270261987481011	134	0.005	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RIBOSOME BIOGENESIS|CELL DIVISION|RNA LOCALIZATION	NUCLEUS|CHROMOSOME		Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p	ribosomal subunit export from nucleus|rRNA export from nucleus	signal transducer activity	nuclear chromatin|integral to membrane|nucleus
YLR305C	YLR305C	STT4	het	Verified	1.8528603175276	0.0319511910649764	no	53	0.0201457507068234	112	0.005	FT	LIPID METABOLISM|SIGNALING	MITOCHONDRION|PLASMA MEMBRANE		Phosphatidylinositol-4-kinase that functions in the Pkc1p protein kinase pathway; required for normal vacuole morphology, cell wall integrity, and actin cytoskeleton organization	phosphatidylinositol phosphorylation	1-phosphatidylinositol 4-kinase activity	mitochondrion|plasma membrane
YOL135C	YOL135C	MED7	het	Verified	1.84761604789227	0.0323289532429726	no	54	0.0311222683369874	190	0.016	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RNA POL II, HOLOENZYME	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation	negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	molecular_function	core mediator complex
YDL060W	YDL060W	TSR1	het	Verified	1.83192253095266	0.0334814816140979	no	55	0.0245351813870342	139	0.017	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress	rRNA processing|ribosome biogenesis	ribonucleoprotein complex binding	nucleolus|cytoplasm|90S preribosome
YOR218C_d	YOR218C	YOR218C	het	Dubious	1.81489569590791	0.0347699700592153	no	56	0.019643966676411	130	0.007					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene RFC1/YOR217W	Unknown	Unknown	Unknown
YNL287W	YNL287W	SEC21	het	Verified	1.8078389401012	0.035315785624846	no	57	0.0491665924938395	246	0.004	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo	retrograde vesicle-mediated transport, Golgi to ER|ER to Golgi vesicle-mediated transport	molecular_function	endosome|COPI vesicle coat
YGL122C	YGL122C	NAB2	het	Verified	1.80415364778172	0.0356036117506867	no	58	0.0177672326997281	149	0.006	FT	RNA PROCESSING|RNA LOCALIZATION	NUCLEUS		Nuclear polyadenylated RNA-binding protein; required for nuclear mRNA export and poly(A) tail length control; binds nuclear pore protein Mlp1p; autoregulates mRNA levels; related to human hnRNPs; nuclear localization sequence binds Kap104p; protein abundance increases in response to DNA replication stress	poly(A)+ mRNA export from nucleus|mRNA polyadenylation|regulation of mRNA stability	poly(A) RNA binding	nucleus|cytoplasm
YJR072C	YJR072C	NPA3	het	Verified	1.79792241614437	0.0360946516507514	no	59	0.0170595494345868	132	0.000	FT	PROTEIN LOCALIZATION|CELL CYCLE|CHROMOSOME SEGREGATION			Member of the conserved GPN-loop GTPase family; has a role in transport of RNA polymerase II to the nucleus; exhibits GTP-dependent binding to PolII; has ATPase activity; involved in sister chromatid cohesion; phosphorylated by the Pcl1p-Pho85p kinase complex; human homolog XAB1 interacts with human RNA polymerase II; protein abundance increases in response to DNA replication stress	cellular protein complex localization|nucleocytoplasmic transport|mitotic sister chromatid cohesion	ATPase activity|GTPase activity	cytoplasm
YBL050W	YBL050W	SEC17	het	Verified	1.79789397405714	0.0360969056239404	no	60	0.0236856243865944	141	0.026	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION			Peripheral membrane protein required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, and autophagy; stimulates the ATPase activity of Sec18p; has similarity to mammalian alpha-SNAP	autophagy|SNARE complex disassembly|vesicle fusion with Golgi apparatus|vacuole fusion, non-autophagic	ATPase activator activity|soluble NSF attachment protein activity	SNARE complex|cytosol|extrinsic to membrane
YFR004W	YFR004W	RPN11	het	Verified	1.77170955132743	0.0382213916735374	no	61	0.0490824282677304	220	0.001	FT	PROTEOLYSIS|MITOCHONDRION ORGANIZATION|PEROXISOME ORGANIZATION	NUCLEUS|MITOCHONDRION		Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid; couples the deubiquitination and degradation of proteasome substrates; involved, independent of catalytic activity, in fission of mitochondria and peroxisomes; protein abundance increases in response to DNA replication stress	protein deubiquitination|proteasomal ubiquitin-dependent protein catabolic process|peroxisome fission|mitochondrial fission	metallopeptidase activity|ubiquitin-specific protease activity	cytosol|mitochondrion|proteasome storage granule|nucleus|proteasome regulatory particle, lid subcomplex
YPR143W	YPR143W	RRP15	het	Verified	1.77073646515042	0.0383022678035687	no	62	0.041894500679676	232	0.012	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Nucleolar protein, constituent of pre-60S ribosomal particles; required for proper processing of the 27S pre-rRNA at the A3 and B1 sites to yield mature 5.8S and 25S rRNAs	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	nucleolus|nucleus|preribosome, large subunit precursor
YBL077W_d	YBL077W	YBL077W	het	Dubious	1.75875590307514	0.0393094888240839	no	63	0.0294576041038949	224	0.017					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ILS1/YBL076C	Unknown	Unknown	Unknown
YHR107C	YHR107C	CDC12	het	Verified	1.74169811810345	0.0407806409938123	no	64	0.0473891285748951	300	0.009	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells	maintenance of cell polarity|cell cycle cytokinesis|positive regulation of protein kinase activity|septin ring assembly	protein complex scaffold|structural molecule activity|GTP binding|GTPase activity|1-phosphatidylinositol binding	septin filament array|cellular bud neck septin ring|septin complex|cytoplasm|mating projection
YHR074W	YHR074W	QNS1	het	Verified	1.73288248518895	0.041558278976321	no	65	0.042299497103652	211	0.016	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	NUCLEUS		Glutamine-dependent NAD(+) synthetase, essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide	NAD biosynthetic process	NAD+ synthase (glutamine-hydrolyzing) activity|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	nucleus|cytoplasm
YGL061C	YGL061C	DUO1	het	Verified	1.71647296638472	0.043037755865684	no	66	0.0227130539468674	128	0.007	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME|CYTOSKELETON	KINETOCHORE	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis	mitotic spindle organization in nucleus|regulation of microtubule polymerization or depolymerization	microtubule binding|structural constituent of cytoskeleton	spindle microtubule|DASH complex|condensed nuclear chromosome kinetochore|spindle pole body|spindle
YLR223C	YLR223C	IFH1	het	Verified	1.70946739819003	0.0436822028547266	no	67	0.0228925559543501	100	0.003	FT	TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|GENE SILENCING	NUCLEUS|CHROMOSOME		Coactivator that regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing	positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter|chromatin silencing at telomere	transcription coactivator activity	nuclear chromatin|nucleolus|nucleus|CURI complex
YOL134C_d	YOL134C	YOL134C	het	Dubious	1.70629207020423	0.0439768568844374	no	68	0.0413441901358185	196	0.012					Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps HRT1, a verified gene that encodes an SCF ubiquitin ligase subunit	Unknown	Unknown	Unknown
YNL240C	YNL240C	NAR1	het	Verified	1.69434451577849	0.0450999180857548	no	69	0.0422622465563162	225	0.011	FT	COFACTOR METABOLISM	NUCLEUS		Component of the cytosolic iron-sulfur (FeS) protein assembly machinery, required for maturation of cytosolic and nuclear FeS proteins and for normal resistance to oxidative stress; homologous to human Narf	iron-sulfur cluster assembly	iron-sulfur cluster binding|ferredoxin hydrogenase activity	cytosol|membrane
YLR215C	YLR215C	CDC123	het	Verified	1.68375121438828	0.0461148795465404	no	70	0.0320318658659888	184	0.030	FT	CELL CYCLE|TRANSLATION|CELL DIVISION			Protein involved in nutritional control of the cell cycle; regulates abundance of the translation initiation factor eIF2; ortholog of human D123 protein	regulation of mitotic cell cycle|regulation of translation	molecular_function	cytoplasm
YFR028C	YFR028C	CDC14	het	Verified	1.65350412504122	0.0491141536396455	no	71	0.0414990070922778	168	0.017	FT	CELL CYCLE	NUCLEUS|CYTOSKELETON		Protein phosphatase required for mitotic exit; located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit; required for meiosis I spindle disassembly; released from nucleolus upon entry into anaphase I of meiosis, resequestered in metaphase II, then released again upon entry into anaphase II; maintained in nucleolus by Cdc55p in early meiosis	regulation of exit from mitosis|mitotic cell cycle|protein dephosphorylation	phosphoprotein phosphatase activity	nucleolus|RENT complex|nucleus|spindle pole body
YDL120W	YDL120W	YFH1	het	Verified	1.63621770577298	0.050897016046345	no	72	0.032961119879495	199	0.002	FT	KETONE METABOLISM|AMINO ACID METABOLISM|ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial matrix iron chaperone; oxidizes and stores iron; interacts with Isu1p to promote Fe-S cluster assembly; mutation results in multiple Fe/S-dependent enzyme deficiencies; human frataxin homolog is mutated in Friedrich's ataxia	cellular iron ion homeostasis|iron-sulfur cluster assembly|glutathione metabolic process	ferrous iron binding|ferroxidase activity|iron chaperone activity	mitochondrion|mitochondrial matrix
YGL155W	YGL155W	CDC43	het	Verified	1.63424176535986	0.0511040480353594	no	73	0.0318498999530036	165	0.023	FT	SIGNALING|ION HOMEOSTASIS|ION HOMEOSTASIS|PROTEIN PRENYLATION			Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis	cellular calcium ion homeostasis|protein geranylgeranylation|establishment of cell polarity|small GTPase mediated signal transduction	protein geranylgeranyltransferase activity|CAAX-protein geranylgeranyltransferase activity	CAAX-protein geranylgeranyltransferase complex|intracellular
YKL014C	YKL014C	URB1	het	Verified	1.61171506710356	0.0535119787182391	no	74	0.0316215298608139	143	0.012	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs, associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	nucleolus
YBR102C	YBR102C	EXO84	het	Verified	1.59947372823303	0.0548576907841045	no	75	0.0380227452394595	209	0.024	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING	SITE OF POLARIZED GROWTH		Exocyst subunit with dual roles in exocytosis and spliceosome assembly; subunit of the the exocyst complex which mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane (PM) prior to SNARE-mediated fusion; required for exocyst assembly and targeting the complex to specific sites on the bud tip PM; associates the U1 snRNP; role in pre-mRNA splicing and prespliceosome formation; possible Cdc28 substrate	spliceosomal complex assembly|Golgi to plasma membrane transport|exocyst localization|exocytosis|exocyst assembly	molecular_function	incipient cellular bud site|mating projection tip|cellular bud neck|cellular bud tip|exocyst
YPL094C	YPL094C	SEC62	het	Verified	1.57568451815392	0.0575492635671553	no	76	0.0522393014668905	283	0.017	FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER	posttranslational protein targeting to membrane, translocation	protein transporter activity	integral to membrane|Sec62/Sec63 complex|endoplasmic reticulum membrane
YMR308C	YMR308C	PSE1	het	Verified	1.55911411265054	0.0594846869963051	no	77	0.0341621898650209	164	0.009	FT	PROTEIN LOCALIZATION|CELL CYCLE|RNA LOCALIZATION	NUCLEUS		Karyopherin/importin that interacts with the nuclear pore complex; acts as the nuclear import receptor for specific proteins, including Pdr1p, Yap1p, Ste12p, and Aft1p	mRNA export from nucleus|regulation of protein desumoylation|protein import into nucleus|regulation of mitosis	protein transporter activity|nuclear localization sequence binding	integral to membrane|nucleus|cytoplasm
YAR008W	YAR008W	SEN34	het	Verified	1.55043976559906	0.0605180001565603	no	78	0.0318062338852861	196	0.017	FT	RNA PROCESSING	ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION		Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease	tRNA-type intron splice site recognition and cleavage	tRNA-intron endonuclease activity	mitochondrial outer membrane|mitochondrion|tRNA-intron endonuclease complex
YFL009W	YFL009W	CDC4	het	Verified	1.53386143339024	0.0625318728225648	no	79	0.0477058456392405	211	0.014	FT	CELL CYCLE|CELL DIVISION|PROTEOLYSIS	NUCLEUS	UBIQUITIN LIGASE COMPLEX	F-box protein required for G1/S and G2/M transition, associates with Skp1p and Cdc53p to form a complex, SCFCdc4, which acts as ubiquitin-protein ligase directing ubiquitination of the phosphorylated CDK inhibitor Sic1p	meiosis|G2/M transition of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|G1/S transition of mitotic cell cycle	ubiquitin-protein ligase activity|ubiquitin binding	nuclear SCF ubiquitin ligase complex|SCF ubiquitin ligase complex|nucleus|nuclear matrix
YDR397C	YDR397C	NCB2	het	Verified	1.52007956713975	0.064245489647841	no	80	0.0336574630635528	191	0.025	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Subunit of a heterodimeric NC2 transcription regulator complex with Bur6p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2beta	negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	transcription coactivator activity|transcription corepressor activity	nucleus|negative cofactor 2 complex
YPR162C	YPR162C	ORC4	het	Verified	1.49522596102728	0.067427740171151	no	81	0.0756373899241657	332	0.018	FT	GENE SILENCING	NUCLEUS|CHROMOSOME		Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing	pre-replicative complex assembly|DNA replication initiation|chromatin silencing at silent mating-type cassette	DNA replication origin binding	DNA replication preinitiation complex|pre-replicative complex|nuclear origin of replication recognition complex
YOR256C	YOR256C	TRE2	het	Verified	1.4771571905182	0.0698167530793622	no	82	0.0765331920958765	365	0.003	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT			Transferrin receptor-like protein; functions with Tre1p to regulate ubiquitylation and vacuolar degradation of the metal transporter Smf1p; inviability of null mutant in systematic studies is due to proximity to CDC31; TRE2 has a paralog, TRE1, that arose from the whole genome duplication	protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	molecular_function	cellular_component
YPR168W	YPR168W	NUT2	het	Verified	1.47405194735341	0.0702338025390615	no	83	0.0519864386340079	253	0.001	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RNA POL II, HOLOENZYME	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for transcriptional activation and has a role in basal transcription; protein abundance increases in response to DNA replication stress	negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	molecular_function	core mediator complex
YKR063C	YKR063C	LAS1	het	Verified	1.47329253729932	0.0703360860465949	no	84	0.0622252870219141	266	0.000	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS|MITOCHONDRION		Protein required for pre-rRNA processing at both ends of ITS2; may coordinate the action of the Rat1p-Rai1p exoRNAse; required for the G1/S transition of the cell cycle; human ortholog is Las1L; mutants require the SSD1-v allele for viability	maturation of LSU-rRNA|maturation of 5.8S rRNA	molecular_function	mitochondrion|nucleus|preribosome|cytoplasm
YDL207W	YDL207W	GLE1	het	Verified	1.47310059346222	0.070361956725081	no	85	0.0549021359719959	257	0.009	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION	NUCLEAR PORE	Cytoplasmic nucleoporin required for polyadenylated RNA export; not essential for protein import; contains a nuclear export signal; when bound to inositol hexakisphosphate (IP6), functions as an activator for the Dbp5p ATPase activity at the nuclear pore complex during mRNA export	poly(A)+ mRNA export from nucleus|mRNA export from nucleus|regulation of translational initiation|regulation of translational termination	translation initiation factor binding|inositol hexakisphosphate binding|phospholipid binding|enzyme activator activity	mitochondrion|integral to membrane|nuclear pore cytoplasmic filaments|nuclear pore|cytoplasm
YIL083C	YIL083C	CAB2	het	Verified	1.46448335539147	0.0715309638057344	no	86	0.0654966900567717	287	0.011	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	NUCLEUS		Probable phosphopantothenoylcysteine synthetase (PPCS), which catalyzes the second step of coenzyme A biosynthesis from pantothenate; null mutant lethality is complemented by E. coli coaBC (encoding a bifunctional enzyme with PPCS activity)	coenzyme A biosynthetic process	phosphopantothenate--cysteine ligase activity	nucleus|cytoplasm
YPR176C	YPR176C	BET2	het	Verified	1.45336036101653	0.0730618630753821	no	87	0.0410325127549521	212	0.008	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN PRENYLATION			Beta subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p	protein targeting to membrane|protein geranylgeranylation|ER to Golgi vesicle-mediated transport	Rab geranylgeranyltransferase activity	Rab-protein geranylgeranyltransferase complex
YOR004W	YOR004W	UTP23	het	Verified	1.4452133546927	0.0741989831883834	no	88	0.0480042017333117	247	0.001	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS|MITOCHONDRION		Component of the small subunit processome, involved in 40S ribosomal subunit biogenesis; interacts with snR30 and is required for dissociation of snR30 from large pre-ribosomal particles; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function; essential protein	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	small-subunit processome|mitochondrion|nucleolus
YDR238C	YDR238C	SEC26	het	Verified	1.44391088768287	0.0743820218008361	no	89	0.124611510167054	475	0.017	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP)	ER to Golgi vesicle-mediated transport	molecular_function	coated vesicle|COPI vesicle coat
YLR127C	YLR127C	APC2	het	Verified	1.42670166405099	0.0768329529004672	no	90	0.0481086647787235	215	0.011	FT	CELL CYCLE|CELL DIVISION|PROTEOLYSIS	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the catalytic core of the APC/C; has similarity to cullin Cdc53p	mitotic metaphase/anaphase transition|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|exit from mitosis|cyclin catabolic process|protein ubiquitination	ubiquitin-protein ligase activity	anaphase-promoting complex
YIL106W	YIL106W	MOB1	het	Verified	1.41586374867774	0.0784077002747058	no	91	0.0800360009436135	327	0.004	FT	CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION	NUCLEUS|SITE OF POLARIZED GROWTH|CHROMOSOME|CYTOSKELETON		Component of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required for cytokinesis and cell separation; component of the CCR4 transcriptional complex; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress	regulation of exit from mitosis|protein phosphorylation	kinase regulator activity	spindle pole body|cellular bud neck
YGL047W	YGL047W	ALG13	het	Verified	1.41231236684554	0.0789290033180828	no	92	0.0793109242143046	354	0.002	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Catalytic component of UDP-GlcNAc transferase; required for the second step of dolichyl-linked oligosaccharide synthesis; anchored to the ER membrane via interaction with Alg14p; similar to bacterial and human glycosyltransferases; protein abundance increases in response to DNA replication stress	dolichol-linked oligosaccharide biosynthetic process	N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity	cytosol|UDP-N-acetylglucosamine transferase complex|extrinsic to endoplasmic reticulum membrane|endoplasmic reticulum|nucleus|cytoplasm
YPL010W	YPL010W	RET3	het	Verified	1.40991973168547	0.0792816928179071	no	93	0.0594096073633578	249	0.006	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Zeta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER	retrograde vesicle-mediated transport, Golgi to ER	molecular_function	COPI vesicle coat
YBR079C	YBR079C	RPG1	het	Verified	1.40345094783686	0.0802412047516504	no	94	0.0604438634613831	261	0.007	FT	TRANSLATION			eIF3a subunit of the core complex of translation initiation factor 3 (eIF3), essential for translation; part of a Prt1p-Rpg1p-Nip1p subcomplex that stimulates binding of mRNA and tRNA(i)Met to ribosomes; involved in translation reinitiation	translation reinitiation|translational initiation	translation initiation factor activity	incipient cellular bud site|eukaryotic translation initiation factor 3 complex|cytoplasmic stress granule|cytoplasm
YDL140C	YDL140C	RPO21	het	Verified	1.39689477916729	0.0812226074078476	no	95	0.0560800281767814	264	0.005	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS|MITOCHONDRION	RNA POL II, HOLOENZYME	RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime	transcription from RNA polymerase II promoter	RNA-directed RNA polymerase activity|DNA-directed RNA polymerase activity	mitochondrion|DNA-directed RNA polymerase II, core complex
YGR211W	YGR211W	ZPR1	het	Verified	1.39182807554623	0.0819872330011631	no	96	0.0662460926742645	205	0.001	FT	CELL CYCLE|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Essential protein with two zinc fingers; present in the nucleus of growing cells but relocates to the cytoplasm in starved cells via a process mediated by Cpr1p; binds to translation elongation factor eEF-1 (Tef1p); relative distribution to the nucleus increases upon DNA replication stress	regulation of mitotic cell cycle|cellular response to starvation	protein binding	nucleus|cytoplasm
YKL022C	YKL022C	CDC16	het	Verified	1.39103403149864	0.0821075536482578	no	97	0.0435484239759906	214	0.003	FT	CELL CYCLE|CELL DIVISION|PROTEOLYSIS	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulation	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|negative regulation of DNA-dependent DNA replication initiation|protein ubiquitination	ubiquitin-protein ligase activity	anaphase-promoting complex
YPL266W	YPL266W	DIM1	het	Verified	1.38800908076079	0.082567139990775	no	98	0.0683784409205543	327	0.005	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing	rRNA modification|rRNA processing	rRNA (adenine-N6,N6-)-dimethyltransferase activity	nucleolus|90S preribosome
YJL109C	YJL109C	UTP10	het	Verified	1.38325438181469	0.0832934401311274	no	99	0.0804234439248524	323	0.002	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS|MITOCHONDRION|CHROMOSOME		Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; mutant has increased aneuploidy tolerance	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|positive regulation of transcription from RNA polymerase I promoter|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	snoRNA binding	mitochondrion|90S preribosome|small-subunit processome|preribosome, small subunit precursor|integral to membrane|t-UTP complex|rDNA heterochromatin|nucleolus
YMR288W	YMR288W	HSH155	het	Verified	1.38085278079678	0.0836621155080206	no	100	0.061163140607187	272	0.023	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING	NUCLEUS		U2-snRNP associated splicing factor that forms extensive associations with the branch site-3' splice site-3' exon region upon prespliceosome formation; similarity to the mammalian U2 snRNP-associated splicing factor SAP155	spliceosomal complex assembly|mRNA splicing, via spliceosome	mRNA binding	U2 snRNP|U2-type prespliceosome
YLR026C	YLR026C	SED5	het	Verified	1.35746116002225	0.0873173632487507	no	101	0.0806109478460571	271	0.001	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins	ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|vesicle fusion with Golgi apparatus|vesicle fusion	SNAP receptor activity	SNARE complex|integral to membrane|cis-Golgi network
YDR499W	YDR499W	LCD1	het	Verified	1.35637989174369	0.0874891639023778	no	102	0.0559912106542033	225	0.025	FT	PROTEIN LOCALIZATION|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p; putative homolog of S. pombe Rad26 and human ATRIP; forms nuclear foci upon DNA replication stress	establishment of protein localization|telomere maintenance via telomerase|DNA damage checkpoint	damaged DNA binding	nuclear chromosome
YBR124W_d	YBR124W	YBR124W	het	Dubious	1.33126700538679	0.091550585364489	no	103	0.073963917665031	330	0.006					Putative protein of unknown function	Unknown	Unknown	Unknown
YHR190W	YHR190W	ERG9	het	Verified	1.32556413184804	0.0924920567902672	no	104	0.0813550275497001	346	0.008	FT	LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		Farnesyl-diphosphate farnesyl transferase (squalene synthase), joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway	ergosterol biosynthetic process	squalene synthase activity|farnesyl-diphosphate farnesyltransferase activity	mitochondrial outer membrane|integral to membrane|endoplasmic reticulum
YKL006C-A	YKL006C-A	SFT1	het	Verified	1.3177988315248	0.0937854995974136	no	105	0.077948561741366	330	0.000	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Intra-Golgi v-SNARE, required for transport of proteins between an early and a later Golgi compartment	intra-Golgi vesicle-mediated transport|vesicle fusion	SNAP receptor activity	SNARE complex|Golgi membrane
YKL060C	YKL060C	FBA1	het	Verified	1.31773802558421	0.0937956802808348	no	106	0.0717865097820144	310	0.017	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Fructose 1,6-bisphosphate aldolase, required for glycolysis and gluconeogenesis; catalyzes conversion of fructose 1,6 bisphosphate to glyceraldehyde-3-P and dihydroxyacetone-P; locates to mitochondrial outer surface upon oxidative stress	gluconeogenesis|glycolysis	fructose-bisphosphate aldolase activity	cytosol|mitochondrion|cytoplasm
YPR178W	YPR178W	PRP4	het	Verified	1.30055202140418	0.0967059193949639	no	107	0.0717487545251934	305	0.009	FT	RNA PROCESSING	NUCLEUS		Splicing factor, component of the U4/U6-U5 snRNP complex	mRNA splicing, via spliceosome	molecular_function	U4/U6 x U5 tri-snRNP complex
YDR299W	YDR299W	BFR2	het	Verified	1.29163123229539	0.0982424413266286	no	108	0.063037513924582	272	0.010	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Essential protein that is a component of 90S preribosomes; may be involved in rRNA processing; multicopy suppressor of sensitivity to Brefeldin A; expression is induced during lag phase and also by cold shock	rRNA processing	molecular_function	nucleolus|90S preribosome
YNL312W	YNL312W	RFA2	het	Verified	1.28164680620793	0.0999832864424926	no	109	0.0641615975232014	254	0.020	FT	PROTEIN LOCALIZATION|CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; protein abundance increases in response to DNA replication stress	establishment of protein localization|telomere maintenance via telomerase|telomere maintenance via recombination|nucleotide-excision repair|DNA repair|mitotic recombination|heteroduplex formation|DNA unwinding involved in replication|reciprocal meiotic recombination|double-strand break repair via homologous recombination|DNA replication|protein ubiquitination	double-stranded DNA binding|single-stranded DNA binding|sequence-specific DNA binding	condensed nuclear chromosome|chromosome, telomeric region|DNA replication factor A complex
YDR367W	YDR367W	KEI1	het	Verified	1.26119387752973	0.103619501979678	no	110	0.130095092343202	479	0.004	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene	inositolphosphoceramide metabolic process	inositol phosphoceramide synthase regulator activity	integral to membrane|Golgi apparatus|integral to Golgi membrane|inositol phosphoceramide synthase complex|cytoplasm
YMR149W	YMR149W	SWP1	het	Verified	1.25733454124273	0.104316260682647	no	111	0.0748897224309972	296	0.012	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Delta subunit of the oligosaccharyl transferase glycoprotein complex, which is required for N-linked glycosylation of proteins in the endoplasmic reticulum	protein N-linked glycosylation	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	oligosaccharyltransferase complex|integral to membrane
YNL313C	YNL313C	EMW1	het	Verified	1.24582756706287	0.106413853324985	no	112	0.0901518542921995	346	0.018	FT	CELL WALL ORG/BIOGENESIS	NUCLEUS		Essential conserved protein with a role in cell wall integrity; contains six TPR (tetratricopeptide repeat) domains clustered in the C-terminal region; conditional mutant is suppressed by overexpression of GFA1; protein abundance increases in response to DNA replication stress	fungal-type cell wall organization	molecular_function	nucleus|cytoplasm
YKL104C	YKL104C	GFA1	het	Verified	1.22751466128873	0.109814607373429	no	113	0.136049811377854	505	0.000	FT	KETONE METABOLISM|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Glutamine-fructose-6-phosphate amidotransferase; catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis; GFA1 has a paralogous region, comprising ORFs YMR084W-YMR085W, that arose from the whole genome duplication	fungal-type cell wall chitin biosynthetic process	glutamine-fructose-6-phosphate transaminase (isomerizing) activity	cellular_component
YKL141W	YKL141W	SDH3	het	Verified	1.22729310723309	0.109856222674901	no	114	0.0853437423940333	296	0.004	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Subunit of both succinate dehydrogenase and of TIM22 translocase; functions as the cytochrome b subunit of succinate dehydrogenase, which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; also required for mitochondrial inner membrane protein import as part of the TIM22 complex	mitochondrial electron transport, succinate to ubiquinone|cellular respiration|tricarboxylic acid cycle|protein import into mitochondrial inner membrane	succinate dehydrogenase (ubiquinone) activity	mitochondrial respiratory chain complex II|mitochondrion|integral to membrane|mitochondrial inner membrane protein insertion complex
YDR182W	YDR182W	CDC1	het	Verified	1.22284875326235	0.110693413712964	no	115	0.0792995825548309	329	0.007	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|ION HOMEOSTASIS|CELL DIVISION|CYTOSKELETON ORGANIZATION|ION HOMEOSTASIS	ENDOPLASMIC RETICULUM		Putative lipid phosphatase of the endoplasmic reticulum; shows Mn2+ dependence and may affect Ca2+ signaling; mutants display actin and general growth defects and pleiotropic defects in cell cycle progression and organelle distribution	DNA repair|cellular manganese ion homeostasis|dephosphorylation|actin cytoskeleton organization	molecular_function	integral to membrane|endoplasmic reticulum
YFR029W	YFR029W	PTR3	het	Verified	1.21613596549552	0.111966565952254	no	116	0.0857653377967024	341	0.000	FT		PLASMA MEMBRANE		Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes	response to amino acid stimulus	molecular_function	extrinsic to plasma membrane
YER006W	YER006W	NUG1	het	Verified	1.21611781165932	0.111970023159336	no	117	0.103519139039128	441	0.010	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		GTPase that associates with nuclear 60S pre-ribosomes, required for export of 60S ribosomal subunits from the nucleus	ribosomal large subunit export from nucleus|rRNA processing	RNA binding|GTPase activity	nucleolus|nucleus|preribosome, large subunit precursor
YBR091C	YBR091C	TIM12	het	Verified	1.20604529352618	0.113900013338852	no	118	0.119212100376393	462	0.001	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins	protein import into mitochondrial inner membrane	phospholipid binding|protein channel activity	mitochondrion|integral to membrane|mitochondrial inner membrane protein insertion complex
YGR179C	YGR179C	OKP1	het	Verified	1.20510809408234	0.114080787769449	no	119	0.0737368535203948	285	0.013	FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME	KINETOCHORE	Outer kinetochore protein required for accurate chromosome segregation; component of COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) a kinetochore sub-complex which functions as a platform for kinetochore assembly; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-Q and fission yeast fta7	attachment of spindle microtubules to kinetochore|chromosome segregation	molecular_function	COMA complex|condensed nuclear chromosome kinetochore
YPR142C_d	YPR142C	YPR142C	het	Dubious	1.19227630794218	0.116576460569912	no	120	0.095016122223152	354	0.011					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RRP15, which is required for ribosomal RNA processing	Unknown	Unknown	Unknown
YFR052W	YFR052W	RPN12	het	Verified	1.18142282012714	0.118717398492187	no	121	0.0972038200184489	372	0.001	FT	PROTEOLYSIS			Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p; protein abundance increases in response to DNA replication stress	ubiquitin-dependent protein catabolic process	molecular_function	proteasome storage granule|proteasome regulatory particle, lid subcomplex
YOR335C	YOR335C	ALA1	het	Verified	1.18038433543377	0.118923694642351	no	122	0.0873775003483859	329	0.001	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Cytoplasmic and mitochondrial alanyl-tRNA synthetase, required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog	alanyl-tRNA aminoacylation|mitochondrial alanyl-tRNA aminoacylation	alanine-tRNA ligase activity	mitochondrion|cytoplasm
YPL153C	YPL153C	RAD53	het	Verified	1.17970321722344	0.119059136938629	no	123	0.110132151695351	414	0.013	FT	PROTEIN LOCALIZATION|CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEOTIDE METABOLISM|PROTEIN PHOSPHORYLATION	NUCLEUS		Protein kinase, required for cell-cycle arrest in response to DNA damage; activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p; also interacts with ARS1 and plays a role in initiation of DNA replication	DNA repair|protein localization|protein phosphorylation|nucleobase-containing compound metabolic process|DNA damage checkpoint|DNA replication initiation|deoxyribonucleoside triphosphate biosynthetic process	protein serine/threonine/tyrosine kinase activity|DNA replication origin binding|protein kinase activity	nucleus
YDR339C	YDR339C	FCF1	het	Verified	1.16624768377765	0.121757159253239	no	124	0.0765060634656412	312	0.005	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Putative PINc domain nuclease required for early cleavages of 35S pre-rRNA and maturation of 18S rRNA; component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; copurifies with Faf1p	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	small-subunit processome|nucleolus
YBR089W_d	YBR089W	YBR089W	het	Dubious	1.161238246957	0.122772512410595	no	125	0.095969004854392	359	0.004					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene POL30	Unknown	Unknown	Unknown
YMR281W	YMR281W	GPI12	het	Verified	1.15750159860017	0.123533743277883	no	126	0.112907127496405	406	0.001	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		ER membrane protein involved in the second step of glycosylphosphatidylinositol (GPI) anchor assembly, the de-N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate; functional homolog of human PIG-Lp	GPI anchor biosynthetic process	N-acetylglucosaminylphosphatidylinositol deacetylase activity	integral to membrane|endoplasmic reticulum membrane
YDR088C	YDR088C	SLU7	het	Verified	1.15697442373267	0.123641404974697	no	127	0.0805063182815278	330	0.006	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING	NUCLEUS		RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain	generation of catalytic spliceosome for second transesterification step	second spliceosomal transesterification activity	spliceosomal complex
YLR272C	YLR272C	YCS4	het	Verified	1.15056739799205	0.124955125931817	no	128	0.101158449442537	392	0.005	FT	CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation, chromatin binding of condensin, tRNA gene clustering at the nucleolus, and silencing at the mating type locus; required for replication slow zone (RSZ) breakage following Mec1p inactivation	maintenance of rDNA|meiotic chromosome condensation|mitotic chromosome condensation|tRNA gene clustering|mitotic sister chromatid segregation|chromatin silencing at silent mating-type cassette	molecular_function	nucleolus|nuclear condensin complex
YGR245C	YGR245C	SDA1	het	Verified	1.14588493387244	0.125921382951996	no	129	0.14847435175801	492	0.004	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RIBOSOME BIOGENESIS|CYTOSKELETON ORGANIZATION	NUCLEUS		Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis	ribosomal large subunit biogenesis|ribosomal large subunit export from nucleus|traversing start control point of mitotic cell cycle|actin cytoskeleton organization	molecular_function	nucleus
YGR246C	YGR246C	BRF1	het	Verified	1.14174988186477	0.126779000061007	no	130	0.0965937195596518	397	0.003	FT	TRANSLATION	NUCLEUS		TFIIIB B-related factor, one of three subunits of RNA polymerase III transcription initiation factor TFIIIB, binds TFIIIC and TBP and recruits RNA pol III to promoters, amino-terminal half is homologous to TFIIB	DNA-dependent transcriptional open complex formation|transposon integration|RNA polymerase III transcriptional preinitiation complex assembly|negative regulation of protein homodimerization activity	TFIIIC-class transcription factor binding|RNA polymerase III core binding|DNA binding|TFIIIB-type transcription factor activity	transcription factor TFIIIB complex
YPR186C	YPR186C	PZF1	het	Verified	1.1386577795653	0.127422959468913	no	131	0.116613212948653	446	0.002	FT		NUCLEUS		Transcription factor IIIA (TFIIIA); essential DNA binding protein required for transcription of 5S rRNA by RNA polymerase III; not involved in transcription of other RNAP III genes; nine conserved zinc fingers; may also bind 5S rRNA	5S class rRNA transcription from RNA polymerase III type 1 promoter	RNA polymerase III type 1 promoter sequence-specific DNA binding|TFIIIC-class transcription factor binding|RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIC recruiting transcription factor activity	nucleus
YPL151C	YPL151C	PRP46	het	Verified	1.13675502468979	0.127820354820098	no	132	0.0867984083146181	336	0.000	FT	CELL CYCLE|RNA PROCESSING	NUCLEUS		Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs	mRNA splicing, via spliceosome	molecular_function	Prp19 complex|spliceosomal complex
YNL149C	YNL149C	PGA2	het	Verified	1.13634455633343	0.127906195034499	no	133	0.0790497222784731	341	0.011	FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect	protein transport	molecular_function	nuclear envelope|endoplasmic reticulum
YHR042W	YHR042W	NCP1	het	Verified	1.12545031565363	0.130199129933664	no	134	0.100561759329024	356	0.003	FT	LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|PLASMA MEMBRANE		NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p	ergosterol biosynthetic process	electron carrier activity	mitochondrial outer membrane|mitochondrion
YOL097C	YOL097C	WRS1	het	Verified	1.12249862778441	0.130825245334577	no	135	0.164188805880454	556	0.001	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION			Cytoplasmic tryptophanyl-tRNA synthetase, aminoacylates tryptophanyl-tRNA	tryptophanyl-tRNA aminoacylation	tryptophan-tRNA ligase activity	cytoplasm
YOR261C	YOR261C	RPN8	het	Verified	1.12112615355245	0.131117083775849	no	136	0.109589037302027	424	0.007	FT	PROTEOLYSIS			Essential, non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11p	ubiquitin-dependent protein catabolic process	molecular_function	proteasome storage granule|proteasome regulatory particle, lid subcomplex
YDR013W	YDR013W	PSF1	het	Verified	1.11376781656896	0.132689403561823	no	137	0.118780662678955	448	0.004	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery	double-strand break repair via break-induced replication|DNA-dependent DNA replication	molecular_function	GINS complex|replication fork protection complex|DNA replication preinitiation complex
YGR082W	YGR082W	TOM20	het	Verified	1.10934532522617	0.133640619519975	no	138	0.0989923703987696	326	0.007	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|RNA LOCALIZATION	MITOCHONDRION		Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins	tRNA import into mitochondrion|protein import into mitochondrial matrix|mitochondrial outer membrane translocase complex assembly	protein channel activity|mitochondrion targeting sequence binding	mitochondrial outer membrane|mitochondrion|integral to membrane|integral to mitochondrial outer membrane|mitochondrial outer membrane translocase complex
YAL034C-B_d	YAL034C-B	YAL034C-B	het	Dubious	1.10231611248691	0.135162133456279	no	139	0.14180652315092	475	0.006					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR060W	YLR060W	FRS1	het	Verified	1.09613644094465	0.136509534677743	no	140	0.121729902977315	451	0.008	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION			Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs2p to generate active enzyme; able to hydrolyze mis-aminoacylated tRNA-Phe, which could contribute to translational quality control	phenylalanyl-tRNA aminoacylation	phenylalanine-tRNA ligase activity	phenylalanine-tRNA ligase complex|cytoplasm
YPL075W	YPL075W	GCR1	het	Verified	1.08859056248748	0.138167240198555	no	141	0.129579176234264	504	0.003	FT	TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY	ENDOMEMBRANE SYSTEM|NUCLEUS		Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p	negative regulation of transcription from RNA polymerase II promoter by glucose|nucleosome organization|positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter|regulation of glycolysis by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from a mobile element promoter|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II distal enhancer sequence-specific DNA binding|RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nuclear envelope
YCR012W	YCR012W	PGK1	het	Verified	1.08587303721721	0.138767583672232	no	142	0.0875955951316348	373	0.001	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis	gluconeogenesis|glycolysis	phosphoglycerate kinase activity	mitochondrion|plasma membrane|cytoplasm
YNL262W	YNL262W	POL2	het	Verified	1.08501944637705	0.138956521247211	no	143	0.0991687603951537	419	0.000	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Catalytic subunit of DNA polymerase (II) epsilon, a chromosomal DNA replication polymerase that exhibits processivity and proofreading exonuclease activity; also involved in DNA synthesis during DNA repair; interacts extensively with Mrc1p	DNA replication involved in S phase|double-strand break repair via nonhomologous end joining|DNA synthesis involved in DNA repair|DNA-dependent DNA replication|mitotic cell cycle DNA replication checkpoint|mitotic sister chromatid cohesion|chromatin silencing at telomere	double-stranded DNA binding|single-stranded DNA binding|DNA-directed DNA polymerase activity	replication fork|epsilon DNA polymerase complex
YKL024C	YKL024C	URA6	het	Verified	1.08453243543455	0.139064396839466	no	144	0.114310938616119	402	0.004	FT	NUCLEOTIDE METABOLISM	NUCLEUS		Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP)	'de novo' pyrimidine nucleobase biosynthetic process|nucleobase-containing compound metabolic process	uridylate kinase activity|adenylate kinase activity	nucleus|cytoplasm
YPL126W	YPL126W	NAN1	het	Verified	1.08023171077158	0.140019505329991	no	145	0.124147536095081	461	0.004	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS|CHROMOSOME		U3 snoRNP protein, component of the small (ribosomal) subunit (SSU) processosome containing U3 snoRNA; required for the biogenesis of18S rRNA	positive regulation of transcription from RNA polymerase I promoter|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	snoRNA binding	small-subunit processome|rDNA heterochromatin|nucleolus|t-UTP complex|RENT complex|90S preribosome
YER171W	YER171W	RAD3	het	Verified	1.0764528722087	0.140862383558809	no	146	0.0982477736613582	356	0.010	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION	NUCLEUS	RNA POL II, HOLOENZYME	5' to 3' DNA helicase; involved in nucleotide excision repair and transcription; subunit of RNA polII initiation factor TFIIH and of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress	regulation of transposition, RNA-mediated|phosphorylation of RNA polymerase II C-terminal domain|nucleotide-excision repair, DNA incision|regulation of mitotic recombination|transcription from RNA polymerase II promoter	damaged DNA binding|ATP-dependent 5'-3' DNA helicase activity|core RNA polymerase binding transcription factor activity	core TFIIH complex|holo TFIIH complex|nucleotide-excision repair factor 3 complex
YGL065C	YGL065C	ALG2	het	Verified	1.06616717005555	0.143174039967486	no	147	0.138163302970933	497	0.004	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Mannosyltransferase that catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol	oligosaccharide-lipid intermediate biosynthetic process	GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity|glycolipid 6-alpha-mannosyltransferase activity	integral to membrane|endoplasmic reticulum
YCL041C_d	YCL041C	YCL041C	het	Dubious	1.06197317510739	0.144123931597627	no	148	0.12839859804953	426	0.001					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps both the verified gene PDI1/YCL043C and the uncharacterized gene YCL042W	Unknown	Unknown	Unknown
YHR020W	YHR020W	YHR020W	het	Verified	1.06083829061815	0.144381698722835	no	149	0.122791623284205	450	0.001	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION			Prolyl-tRNA synthetase; N-terminal domain shows weak homology to prokaryotic posttransfer editing domain, but does not possess posttransfer editing activity; may interact with ribosomes, based on co-purification experiments	chromosome organization|tRNA aminoacylation for protein translation	proline-tRNA ligase activity	ribosome
YNL007C	YNL007C	SIS1	het	Verified	1.05988592238088	0.144598250426927	no	150	0.110107109983009	352	0.001	FT	CELL CYCLE|TRANSLATION	NUCLEUS	RIBOSOME	Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p; not functionally redundant with Ydj1p due to due to substrate specificity; has similarity to bacterial DnaJ proteins; protein abundance increases in response to DNA replication stress	protein folding|translational initiation	unfolded protein binding	cytosolic small ribosomal subunit
YMR047C	YMR047C	NUP116	het	Verified	1.05848870108018	0.144916349649294	no	151	0.121061725085784	434	0.005	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup159p)	poly(A)+ mRNA export from nucleus|mRNA export from nucleus|ribosomal large subunit export from nucleus|protein import into nucleus|nuclear pore organization|tRNA export from nucleus	nucleocytoplasmic transporter activity|structural constituent of nuclear pore	nuclear pore central transport channel|integral to membrane|nuclear pore cytoplasmic filaments|nuclear pore
YBR110W	YBR110W	ALG1	het	Verified	1.05371718618553	0.146006209057806	no	152	0.130247199197612	479	0.003	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Mannosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability, mutation is functionally complemented by human ortholog	oligosaccharide-lipid intermediate biosynthetic process|protein N-linked glycosylation	beta-1,4-mannosyltransferase activity	integral to membrane|endoplasmic reticulum
YAR007C	YAR007C	RFA1	het	Verified	1.05093426791012	0.146644390208944	no	153	0.181810595735131	588	0.013	FT	PROTEIN LOCALIZATION|CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination	establishment of protein localization|telomere maintenance via telomerase|telomere maintenance via recombination|nucleotide-excision repair|DNA repair|mitotic recombination|heteroduplex formation|DNA unwinding involved in replication|reciprocal meiotic recombination|DNA replication|double-strand break repair via homologous recombination|protein ubiquitination	double-stranded DNA binding|single-stranded DNA binding|sequence-specific DNA binding	condensed nuclear chromosome|chromosome, telomeric region|DNA replication factor A complex|cytoplasm
YGR005C	YGR005C	TFG2	het	Verified	1.03791464906119	0.149654896433597	no	154	0.124147020209045	474	0.001	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RNA POL II, HOLOENZYME	TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30	transcriptional start site selection at RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|promoter clearance from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter	core RNA polymerase II binding transcription factor activity|core RNA polymerase II recruiting transcription factor activity	transcription factor TFIIF complex
YKL049C	YKL049C	CSE4	het	Verified	1.03641546936132	0.150004178274941	no	155	0.107543131007517	405	0.004	FT	CELL CYCLE|CHROMATIN ORGANIZATION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME	KINETOCHORE	Centromere protein that resembles histone H3; required for proper kinetochore function; homolog of human CENP-A; levels are regulated by E3 ubiquitin ligase Psh1p; Cse4p marks a subset of open chromatin; associated with promoters, accessible chromatin and RNA polymerase II-bound regions	2-micrometer plasmid partitioning|mitotic sister chromatid segregation	sequence-specific DNA binding|centromeric DNA binding	extrachromosomal circular DNA|nuclear nucleosome|condensed nuclear chromosome, centromeric region|centromere-specific nucleosome|kinetochore
YER159C	YER159C	BUR6	het	Verified	1.03257441291124	0.150901553731143	no	156	0.123276703904414	423	0.003	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha	negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	transcription coactivator activity|transcription corepressor activity	nucleus|negative cofactor 2 complex
YDL007W	YDL007W	RPT2	het	Verified	1.02978957120679	0.151554398674946	no	157	0.135717625224228	455	0.001	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS	NUCLEUS		One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle	positive regulation of protein catabolic process|proteasome regulatory particle assembly|peptide catabolic process|ubiquitin-dependent protein catabolic process	ATPase activity	proteasome regulatory particle, base subcomplex|nucleus
YNL163C	YNL163C	RIA1	het	Verified	1.02891365851138	0.151760124743258	no	158	0.140921094144669	491	0.003	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEOTIDE METABOLISM			Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis; with Sdo1p, promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; required for quality control check of newly made large ribosomal subunits before they are released into the pool of translating ribosomes	mature ribosome assembly	GTPase activity	cytoplasm
YPL128C	YPL128C	TBF1	het	Verified	1.02616399384579	0.152407145068221	no	159	0.134460356108038	445	0.011	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|GENE SILENCING	NUCLEUS|CHROMOSOME		Telobox-containing general regulatory factor; binds TTAGGG repeats within subtelomeric anti-silencing regions (STARs), blocking silent chromatin propagation; binds majority of snoRNA gene promoters, required for full snoRNA expression; caps DSB flanked by long T2AG3 repeats and blocks checkpoint activation	telomere maintenance via telomere lengthening|negative regulation of chromatin silencing|snoRNA transcription from an RNA polymerase II promoter|negative regulation of telomere maintenance via telomerase	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|chromatin insulator sequence binding|telomeric DNA binding	nuclear chromosome, telomeric region|nucleus
YGR218W	YGR218W	CRM1	het	Verified	1.01554068421297	0.154924081662016	no	160	0.149351593337246	499	0.006	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION	NUCLEUS|CHROMOSOME|CYTOSKELETON	KINETOCHORE	Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus; exportin	mRNA export from nucleus|protein export from nucleus|protein localization to kinetochore|ribosomal large subunit export from nucleus	protein transporter activity	integral to membrane|nucleus|spindle pole body|kinetochore
YKR083C	YKR083C	DAD2	het	Verified	1.00959211948811	0.15634537337158	no	161	0.185313805749488	633	0.004	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME|CYTOSKELETON	KINETOCHORE	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis	mitotic spindle organization in nucleus|regulation of microtubule polymerization or depolymerization	microtubule binding|structural constituent of cytoskeleton	DASH complex|condensed nuclear chromosome kinetochore|mitotic spindle
YBR143C	YBR143C	SUP45	het	Verified	1.00548712708759	0.157331172491768	no	162	0.166175591483033	599	0.003	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|CELL DIVISION			Polypeptide release factor (eRF1) in translation termination; mutant form acts as a recessive omnipotent suppressor; methylated by Mtq2p-Trm112p in ternary complex eRF1-eRF3-GTP; mutation of methylation site confers resistance to zymocin; has a role in cytokinesis through interaction with Mlc1p	translational termination|cytokinesis	translation release factor activity, codon specific|translation release factor activity	cytosol|translation release factor complex
YHR062C	YHR062C	RPP1	het	Verified	1.00268674902224	0.158006012670288	no	163	0.344924269990998	1156	0.012	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs	tRNA processing|intronic box C/D snoRNA processing|mRNA cleavage|rRNA processing	ribonuclease MRP activity|ribonuclease P activity	nucleolar ribonuclease P complex|ribonuclease MRP complex
YKR038C	YKR038C	KAE1	het	Verified	0.991009588076677	0.160840449231459	no	164	0.132244784125817	452	0.007	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|PROTEOLYSIS	NUCLEUS|CHROMOSOME		Highly conserved ATPase of HSP70/DnaK family; component of the EKC/KEOPS complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription	chromosome organization|threonylcarbamoyladenosine metabolic process|telomere maintenance|positive regulation of transcription from RNA polymerase II promoter	chromatin DNA binding	nuclear chromatin|EKC/KEOPS complex|nucleus|cytoplasm
YOR207C	YOR207C	RET1	het	Verified	0.983525576551163	0.16267441684843	no	165	0.138401489466154	566	0.000	FF|FT		NUCLEUS		Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs	tRNA transcription from RNA polymerase III promoter	DNA-directed RNA polymerase activity	DNA-directed RNA polymerase III complex
YIL051C	YIL051C	MMF1	het	Verified	0.983482573100363	0.16268499405855	no	166	0.1405666240043	460	0.004	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial protein required for transamination of isoleucine but not of valine or leucine; may regulate specificity of branched-chain transaminases Bat1p and Bat2p; interacts genetically with mitochondrial ribosomal protein genes	isoleucine biosynthetic process|mitochondrial translation	molecular_function	mitochondrion|mitochondrial matrix
YDR413C_d	YDR413C	YDR413C	het	Dubious	0.97907273952824	0.163772019993818	no	167	0.178901757583949	609	0.006					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the essential uncharacterized ORF YDR412W that is implicated in rRNA processing	Unknown	Unknown	Unknown
YNL260C	YNL260C	LTO1	het	Verified	0.972783241420425	0.16533052174296	no	168	0.119218958384412	453	0.011	FT		NUCLEUS		Essential protein that forms a complex with Rli1p and Yae1p; ortholog of human ORAOV1, which is overexpressed in solid tumors; inviability of null mutant under standard conditions is complemented by overexpression of ORAOV1; essential for growth under standard (aerobic) conditions but not under anaerobic conditions; may have a role in protection of ribosomal assembly and function from damage due to reactive oxygen species	biological_process	molecular_function	nucleus|cytoplasm
YGR185C	YGR185C	TYS1	het	Verified	0.962224309337391	0.167968470256171	no	169	0.109228823380928	403	0.003	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION	NUCLEUS		Cytoplasmic tyrosyl-tRNA synthetase; required for cytoplasmic protein synthesis; interacts with positions 34 and 35 of the tRNATyr anticodon; mutations in human ortholog YARS are associated with Charcot-Marie-Tooth (CMT) neuropathies; protein abundance increases in response to DNA replication stress	tyrosyl-tRNA aminoacylation	tyrosine-tRNA ligase activity	nucleus|cytoplasm
YLR101C_d	YLR101C	YLR101C	het	Dubious	0.959275360531172	0.168710022313986	no	170	0.138075717737924	472	0.005					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF ERG27/YLR100W	Unknown	Unknown	Unknown
YDR232W	YDR232W	HEM1	het	Verified	0.953927466978747	0.17006017945721	no	171	0.173506070808753	608	0.000	FT	COFACTOR METABOLISM	MITOCHONDRION		5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p	heme biosynthetic process	5-aminolevulinate synthase activity	mitochondrion|mitochondrial matrix
YJL041W	YJL041W	NSP1	het	Verified	0.953642025044428	0.170132437773275	no	172	0.168493997269798	587	0.017	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RIBOSOME BIOGENESIS|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nup82p, Gle2p and two other FG-nucleoporins (Nup159p and Nup116p); also found in stable complex with Nic96p and two other FG-nucleoproteins (Nup49p and Nup57p); forms foci at the nuclear periphery upon DNA replication stress	poly(A)+ mRNA export from nucleus|NLS-bearing substrate import into nucleus|ncRNA export from nucleus|ribosomal large subunit export from nucleus|tRNA export from nucleus|protein import into nucleus|ribosomal small subunit export from nucleus	nucleocytoplasmic transporter activity|phospholipid binding|structural constituent of nuclear pore	nuclear pore central transport channel|integral to membrane|nuclear pore nuclear basket|nuclear pore
YOR168W	YOR168W	GLN4	het	Verified	0.936960241412172	0.1743895048363	no	173	0.166848669886314	575	0.001	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION	MITOCHONDRION		Glutamine tRNA synthetase, monomeric class I tRNA synthetase that catalyzes the specific glutaminylation of tRNA(Glu); N-terminal domain proposed to be involved in enzyme-tRNA interactions	glutaminyl-tRNA aminoacylation	glutamine-tRNA ligase activity	cytosol|mitochondrion
YPR175W	YPR175W	DPB2	het	Verified	0.936367906050536	0.174541898129625	no	174	0.132871615595015	511	0.003	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Second largest subunit of DNA polymerase II (DNA polymerase epsilon), required for maintenance of fidelity of chromosomal replication; expression peaks at the G1/S phase boundary; Cdc28p substrate	DNA-dependent DNA replication	double-stranded DNA binding|single-stranded DNA binding|DNA-directed DNA polymerase activity	nucleus|epsilon DNA polymerase complex|cytoplasm
YER048W-A	YER048W-A	ISD11	het	Verified	0.933291394995534	0.175334768419097	no	175	0.152902027863815	549	0.006	FT	COFACTOR METABOLISM	MITOCHONDRION		Cysteine desulfurase (Nfs1p) activator; essential for the formation of the persulfide intermediate at the desulfurase active site during pyridoxal phosphate-dependent desulfuration of cysteine; required for mitochondrial iron-sulfur cluster biosynthesis	iron-sulfur cluster assembly	enzyme activator activity	extrinsic to mitochondrial inner membrane|mitochondrion|mitochondrial matrix
YHR085W	YHR085W	IPI1	het	Verified	0.927013269841944	0.176959822276289	no	176	0.1325093929631	455	0.008	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and possibly pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; IPI1 is an essential gene	ribosomal large subunit assembly|rRNA processing	molecular_function	nucleoplasm|nucleus
YLR066W	YLR066W	SPC3	het	Verified	0.918736623545818	0.179116674402009	no	177	0.13317527053522	480	0.007	FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23	signal peptide processing|protein targeting to ER	peptidase activity	signal peptidase complex
YOR326W	YOR326W	MYO2	het	Verified	0.912074861556895	0.180864655288882	no	178	0.143187593466326	505	0.000	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|PEROXISOME ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Type V myosin motor involved in actin-based transport of cargos; required for the polarized delivery of secretory vesicles, the vacuole, late Golgi elements, peroxisomes, and the mitotic spindle; MYO2 has a paralog, MYO4, that arose from the whole genome duplication	vacuole inheritance|establishment of mitotic spindle orientation|peroxisome inheritance|budding cell apical bud growth|unidimensional cell growth|mitochondrion inheritance|membrane addition at site of cytokinesis|vesicle transport along actin filament|vesicle-mediated transport|Golgi inheritance	microfilament motor activity|actin filament binding|calmodulin binding	fungal-type vacuole membrane|incipient cellular bud site|filamentous actin|myosin V complex|actin filament bundle|cellular bud neck|cellular bud tip|vesicle|mating projection tip
YGR128C	YGR128C	UTP8	het	Verified	0.911692726286657	0.180965247023704	no	179	0.20729995037619	708	0.001	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|RNA LOCALIZATION	NUCLEUS|CHROMOSOME		Nucleolar protein required for export of tRNAs from the nucleus; also copurifies with the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA	positive regulation of transcription from RNA polymerase I promoter|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|tRNA export from nucleus	snoRNA binding|tRNA binding	small-subunit processome|t-UTP complex|nucleolus|rDNA heterochromatin|90S preribosome
YOR122C	YOR122C	PFY1	het	Verified	0.910662883255208	0.181236513226342	no	180	0.185537157796799	617	0.005	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	PLASMA MEMBRANE|CYTOSKELETON		Profilin; binds actin, phosphatidylinositol 4,5-bisphosphate, and polyproline regions; involved in cytoskeleton organization; required for normal timing of actin polymerization in response to thermal stress; protein abundance increases in response to DNA replication stress	positive regulation of formin-nucleated actin cable assembly|sequestering of actin monomers|intracellular transport	actin monomer binding|phosphatidylinositol-4,5-bisphosphate binding|proline-rich region binding	cytosol|extrinsic to plasma membrane
YPL233W	YPL233W	NSL1	het	Verified	0.905809106070696	0.182518450189614	no	181	0.185556449529857	605	0.002	FT	CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME|CYTOSKELETON	KINETOCHORE	Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation	chromosome segregation	molecular_function	nuclear MIS12/MIND type complex|kinetochore|spindle pole
YKL203C	YKL203C	TOR2	het	Verified	0.903342338181995	0.183172116392373	no	182	0.123565985998368	436	0.003	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|MEMBRANE ORGANIZATION|RIBOSOME BIOGENESIS|SIGNALING|CYTOSKELETON ORGANIZATION	MITOCHONDRION|PLASMA MEMBRANE		PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication	G1 phase of mitotic cell cycle|regulation of cell cycle|actin filament reorganization involved in cell cycle|positive regulation of endocytosis|regulation of cell growth|establishment or maintenance of actin cytoskeleton polarity|Rho protein signal transduction|ribosome biogenesis|signal transduction|TOR signaling cascade|cytoskeleton organization|negative regulation of autophagy	protein binding|protein serine/threonine kinase activity	TORC1 complex|TORC2 complex|mitochondrion|fungal-type vacuole membrane|extrinsic to internal side of plasma membrane|plasma membrane|cytoplasm
YBR167C	YBR167C	POP7	het	Verified	0.900276011919781	0.183986691768264	no	183	0.144404177092392	518	0.005	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs	tRNA processing|intronic box C/D snoRNA processing|mRNA cleavage|rRNA processing	ribonuclease MRP activity|ribonuclease P activity	nucleolar ribonuclease P complex|ribonuclease MRP complex
YCR072C	YCR072C	RSA4	het	Verified	0.895723081614619	0.185200339835439	no	184	0.145130604578748	498	0.001	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS	NUCLEUS		WD-repeat protein involved in ribosome biogenesis; may interact with ribosomes; required for maturation and efficient intra-nuclear transport or pre-60S ribosomal subunits, localizes to the nucleolus	ribosomal large subunit assembly	molecular_function	ribosome|nucleolus
YOL130W	YOL130W	ALR1	het	Verified	0.894948840474424	0.185407218321281	no	185	0.193875822973387	663	0.001	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions	magnesium ion transport|cation transport	inorganic cation transmembrane transporter activity	integral to membrane|plasma membrane
YEL055C	YEL055C	POL5	het	Verified	0.893938432743358	0.185677416577341	no	186	0.155635721513842	540	0.001	FT		NUCLEUS		DNA Polymerase phi; has sequence similarity to the human MybBP1A and weak sequence similarity to B-type DNA polymerases, not required for chromosomal DNA replication; required for the synthesis of rRNA	rRNA transcription|DNA replication	DNA-directed DNA polymerase activity	nucleolus
YPL085W	YPL085W	SEC16	het	Verified	0.893168539474642	0.185883461545857	no	187	0.165908428497212	570	0.000	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		COPII vesicle coat protein required for ER transport vesicle budding; Sec16p is bound to the periphery of ER membranes and may act to stabilize initial COPII complexes; interacts with Sec23p, Sec24p and Sec31p	COPII vesicle coating	protein anchor	ER to Golgi transport vesicle membrane
YDR201W	YDR201W	SPC19	het	Verified	0.892933622766913	0.185946360048981	no	188	0.148048609587891	495	0.000	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME|CYTOSKELETON	KINETOCHORE	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body	microtubule nucleation|mitotic spindle organization in nucleus|regulation of microtubule polymerization or depolymerization	microtubule binding|structural constituent of cytoskeleton	spindle microtubule|condensed nuclear chromosome kinetochore|DASH complex|spindle pole body|spindle
YFL017W-A	YFL017W-A	SMX2	het	Verified	0.89272063964551	0.186003397280755	no	189	0.170351701362528	587	0.000	FT	RNA PROCESSING	NUCLEUS		Core Sm protein Sm G; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx3p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm G	mRNA splicing, via spliceosome	molecular_function	U1 snRNP|U2-type prespliceosome|U4/U6 x U5 tri-snRNP complex|U5 snRNP
YJL054W	YJL054W	TIM54	het	Verified	0.892357007286736	0.18610080369312	no	190	0.178192004781591	618	0.001	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane	protein import into mitochondrial inner membrane	protein channel activity	mitochondrion|integral to membrane|mitochondrial inner membrane protein insertion complex
YDL045C	YDL045C	FAD1	het	Verified	0.891408023639424	0.186355157392445	no	191	0.168740682319022	572	0.000	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			Flavin adenine dinucleotide (FAD) synthetase, performs the second step in synthesis of FAD from riboflavin	FAD biosynthetic process	FMN adenylyltransferase activity	cytoplasm
YBR135W	YBR135W	CKS1	het	Verified	0.891202269415011	0.186410333576144	no	192	0.170532949319181	556	0.001	FT	CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION	NUCLEUS		Cyclin-dependent protein kinase regulatory subunit and adaptor; modulates proteolysis of M-phase targets through interactions with the proteasome; role in transcriptional regulation, recruiting proteasomal subunits to target gene promoters	positive regulation of transcription, DNA-dependent|regulation of cell cycle|transcription, DNA-dependent|chromatin remodeling	ubiquitin binding|protein kinase activator activity|histone binding	cyclin-dependent protein kinase holoenzyme complex|nucleus|cytoplasm
YNL290W	YNL290W	RFC3	het	Verified	0.890179538138825	0.186684744955259	no	193	0.166426561319757	555	0.003	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon	mismatch repair|sister chromatid cohesion|leading strand elongation	DNA clamp loader activity|ATPase activity	Elg1 RFC-like complex|DNA replication factor C complex|Rad17 RFC-like complex|nucleus|Ctf18 RFC-like complex
YGL091C	YGL091C	NBP35	het	Verified	0.886706053540108	0.187618589175283	no	194	0.147254828510493	493	0.004	FT	RNA PROCESSING|COFACTOR METABOLISM	NUCLEUS		Essential iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Cfd1p that is involved in iron-sulfur protein assembly in the cytosol; similar to P-loop NTPases	iron-sulfur cluster assembly|tRNA wobble uridine modification	4 iron, 4 sulfur cluster binding|ATPase activity|iron ion binding	mitochondrion|nucleus|cytoplasm
YDR376W	YDR376W	ARH1	het	Verified	0.882305342719941	0.188805854010804	no	195	0.168098598846669	591	0.002	FT	KETONE METABOLISM|ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability	ubiquinone biosynthetic process|cellular iron ion homeostasis	NADPH-adrenodoxin reductase activity	mitochondrion|mitochondrial inner membrane
YLR259C	YLR259C	HSP60	het	Verified	0.880239400589275	0.189364816612919	no	196	0.152064120875147	546	0.006	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated	protein refolding|protein stabilization|chaperone-mediated protein complex assembly|'de novo' protein folding|protein maturation|protein import into mitochondrial intermembrane space	unfolded protein binding|DNA replication origin binding|single-stranded DNA binding|ATPase activity|chaperone binding	mitochondrial nucleoid|mitochondrion
YDR325W	YDR325W	YCG1	het	Verified	0.873864557454737	0.191096009106092	no	197	0.198448714993888	667	0.002	FT	CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation and chromatin binding of the condensin complex; required for clustering of tRNA genes at the nucleolus; required for replication slow zone (RSZ) breakage following Mec1p inactivation	rDNA condensation|meiotic chromosome condensation|mitotic chromosome condensation|tRNA gene clustering|mitotic sister chromatid segregation	molecular_function	nuclear condensin complex
YPL028W	YPL028W	ERG10	het	Verified	0.871513402159352	0.191736945668573	no	198	0.167738774314955	597	0.012	FT	LIPID METABOLISM			Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis	ergosterol biosynthetic process	acetyl-CoA C-acetyltransferase activity	cytosol
YFL005W	YFL005W	SEC4	het	Verified	0.859772042652482	0.194957356614838	no	199	0.184386642403402	663	0.002	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|SIGNALING|CELL DIVISION	ENDOMEMBRANE SYSTEM|MITOCHONDRION|PLASMA MEMBRANE|CYTOSKELETON		Rab family GTPase essential for vesicle-mediated exocytic secretion and autophagy; associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane	bipolar cellular bud site selection|autophagy|exocytosis|Golgi to plasma membrane transport|small GTPase mediated signal transduction|ascospore-type prospore assembly|membrane addition at site of cytokinesis|vesicle fusion|cytokinesis	GTP binding|GTPase activity	mitochondrial outer membrane|vesicle|incipient cellular bud site|mitochondrion|transport vesicle|actin cap|plasma membrane
YMR059W	YMR059W	SEN15	het	Verified	0.858130765162898	0.195410130501705	no	200	0.167805393054846	607	0.006	FT	RNA PROCESSING	ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION		Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p	tRNA-type intron splice site recognition and cleavage	tRNA-intron endonuclease activity	tRNA-intron endonuclease complex
YMR220W	YMR220W	ERG8	het	Verified	0.852117784340535	0.197074361080789	no	201	0.190764331823395	647	0.015	FT	LIPID METABOLISM|COFACTOR METABOLISM	NUCLEUS		Phosphomevalonate kinase, an essential cytosolic enzyme that acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate	organic acid phosphorylation|ergosterol biosynthetic process|isopentenyl diphosphate biosynthetic process, mevalonate pathway|farnesyl diphosphate biosynthetic process, mevalonate pathway	phosphomevalonate kinase activity	nucleus|cytoplasm
YLR147C	YLR147C	SMD3	het	Verified	0.836722855718181	0.201374184426909	no	202	0.1963513065106	714	0.009	FT	RNA PROCESSING	NUCLEUS		Core Sm protein Sm D3; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D3	mRNA splicing, via spliceosome	mRNA binding	commitment complex|U1 snRNP|U2-type prespliceosome|U4/U6 x U5 tri-snRNP complex|U5 snRNP
YML064C	YML064C	TEM1	het	Verified	0.827695486660795	0.20392148790426	no	203	0.190115621427204	616	0.009	FT	CELL CYCLE|SIGNALING|CELL DIVISION	CYTOSKELETON		GTP-binding protein of the ras superfamily involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis	regulation of exit from mitosis	protein binding|GTPase activity	spindle pole body
YKL108W	YKL108W	SLD2	het	Verified	0.818236361822801	0.206611118002841	no	204	0.159526127156005	573	0.010	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS		Single-stranded DNA origin-binding and annealing protein; required for the initiation of DNA replication; phosphorylated in S phase by cyclin-dependent kinases (Cdks), promoting origin binding, DNA replication and Dpb11p complex formation; component of the preloading complex; unphosphorylated or CDK-phosphorylated Sld2p binds to the MCM2-7 complex;required for the S phase checkpoint; relative distribution to the nucleus increases upon DNA replication stress	DNA replication preinitiation complex assembly|DNA strand renaturation|DNA replication initiation|double-strand break repair via break-induced replication|mitotic cell cycle DNA replication checkpoint	DNA replication origin binding|single-stranded DNA binding	DNA replication preinitiation complex
YJL035C	YJL035C	TAD2	het	Verified	0.808620322913753	0.209366785649488	no	205	0.17263563642507	580	0.002	FT	RNA PROCESSING	NUCLEUS		Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNAs	tRNA modification	tRNA-specific adenosine deaminase activity	nucleus|cytoplasm
YDR365C	YDR365C	ESF1	het	Verified	0.806177803385948	0.210070167653601	no	206	0.154850446379648	510	0.002	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels	rRNA processing	RNA binding	nucleolus|nucleus
YPR033C	YPR033C	HTS1	het	Verified	0.804627133418866	0.210517439790566	no	207	0.166453052674917	582	0.004	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Cytoplasmic and mitochondrial histidine tRNA synthetase; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence; mutations in human ortholog HARS2 are associated with Perrault syndrome	histidyl-tRNA aminoacylation|mitochondrial translation	aminoacyl-tRNA ligase activity	mitochondrion|cytoplasm
YDR308C	YDR308C	SRB7	het	Verified	0.800515240124832	0.211706168636008	no	208	0.191661121332646	649	0.002	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RNA POL II, HOLOENZYME	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; target of the global repressor Tup1p	negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II transcription coactivator activity|RNA polymerase II repressing transcription factor binding|RNA polymerase II transcription corepressor activity	core mediator complex
YKL210W	YKL210W	UBA1	het	Verified	0.798721945812789	0.212225829324538	no	209	0.211453330732445	738	0.000	FT		NUCLEUS		Ubiquitin activating enzyme (E1); involved in ubiquitin-mediated protein degradation and essential for viability; protein abundance increases in response to DNA replication stress	protein ubiquitination	ubiquitin activating enzyme activity	nucleus|cytoplasm
YOL034W	YOL034W	SMC5	het	Verified	0.798403323304093	0.212318237676924	no	210	0.195806532620909	613	0.005	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; binds single-stranded DNA and has ATPase activity; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair	DNA repair|resolution of recombination intermediates|recombinational repair|rDNA separation	damaged DNA binding|single-stranded DNA binding|ATPase activity	Smc5-Smc6 complex|nucleus
YDR208W	YDR208W	MSS4	het	Verified	0.793561769134327	0.213725298182725	no	211	0.18429979876885	642	0.003	FT	LIPID METABOLISM	NUCLEUS|PLASMA MEMBRANE		Phosphatidylinositol-4-phosphate 5-kinase, involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation	phosphatidylinositol phosphorylation|ascospore-type prospore assembly	1-phosphatidylinositol-4-phosphate 5-kinase activity	nucleus|plasma membrane
YBR252W	YBR252W	DUT1	het	Verified	0.790417953065528	0.214641860438574	no	212	0.227793672974619	789	0.005	FT	NUCLEOTIDE METABOLISM	NUCLEUS		deoxyuridine triphosphate diphosphatase (dUTPase); catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability; also has diphosphatase activity on deoxyinosine triphosphate	pyrimidine deoxyribonucleoside triphosphate catabolic process|dUTP catabolic process|dITP catabolic process	dITP diphosphatase activity|dUTP diphosphatase activity	nucleus|cytoplasm
YLR317W_d	YLR317W	YLR317W	het	Dubious	0.785160952114538	0.216179603230778	no	213	0.19168894837053	673	0.011					Dubious open reading frame; may be part of a bicistronic transcript with NKP2/YLR315W; overlaps the verified ORF TAD3/YLR316C	Unknown	Unknown	Unknown
YPL235W	YPL235W	RVB2	het	Verified	0.773856826510793	0.219507731551817	no	214	0.290485023945651	968	0.000	FF|FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		ATP-dependent DNA helicase, also known as reptin; member of the AAA+ and RuvB protein families, similar to Rvb1p; conserved component of multiple complexes including the INO80 complex, the Swr1 complex, and the R2TP complex (Rvb1-Rvb2-Tah1-Pih1); involved in multiple processes such as chromatin remodeling, box C/D snoRNP assembly, and RNA polymerase II assembly	regulation of transcription from RNA polymerase II promoter|rRNA processing|chromatin remodeling|box C/D snoRNP assembly|histone exchange	ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 3'-5' DNA helicase activity	nuclear telomeric heterochromatin|ASTRA complex|R2TP complex|Swr1 complex|nucleus|Ino80 complex
YBR211C	YBR211C	AME1	het	Verified	0.77382650163361	0.2195166991189	no	215	0.193616551505766	674	0.001	FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME|CYTOSKELETON	KINETOCHORE	Essential kinetochore protein associated with microtubules and SPBs; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p); involved in spindle checkpoint maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-U and fission yeast Mis17; relative distribution to the nucleus increases upon DNA replication stress	attachment of spindle microtubules to kinetochore|protein localization to kinetochore	molecular_function	COMA complex|spindle pole body|kinetochore
YML065W	YML065W	ORC1	het	Verified	0.773092414626179	0.219733844969731	no	216	0.174521300191201	557	0.001	FT	GENE SILENCING	NUCLEUS|CHROMOSOME		Largest subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; exhibits ATPase activity	pre-replicative complex assembly|DNA replication initiation|chromatin silencing at silent mating-type cassette	chromatin binding|DNA replication origin binding|ATPase activity|ATP binding	DNA replication preinitiation complex|nucleus|pre-replicative complex|nuclear origin of replication recognition complex
YNL126W	YNL126W	SPC98	het	Verified	0.772166780499356	0.220007826925686	no	217	0.248083754984979	893	0.007	FF|FT	CELL CYCLE|CYTOSKELETON ORGANIZATION	NUCLEUS|CYTOSKELETON		Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque	microtubule nucleation|mitotic spindle organization in nucleus	structural constituent of cytoskeleton	outer plaque of spindle pole body|gamma-tubulin small complex, spindle pole body|inner plaque of spindle pole body
YKL089W	YKL089W	MIF2	het	Verified	0.765193974228331	0.222078023656527	no	218	0.198942381874635	720	0.000	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME	KINETOCHORE	Protein required for structural integrity of elongating spindles; localizes to the kinetochore; interacts with histones H2A, H2B, and H4; phosphorylated by Ipl1p; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-C and fission yeast cnp3	chromosome segregation|mitotic spindle organization in nucleus	centromeric DNA binding	condensed nuclear chromosome, centromeric region|condensed nuclear chromosome inner kinetochore
YLR243W	YLR243W	GPN3	het	Verified	0.765022944178878	0.222128941084332	no	219	0.18066342830104	614	0.004	FT	PROTEIN LOCALIZATION			Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn2p	biological_process	signal sequence binding	cellular_component
YMR235C	YMR235C	RNA1	het	Verified	0.760800969310841	0.223387977685532	no	220	0.204411011326497	676	0.000	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION|GENE SILENCING	NUCLEUS		GTPase activating protein (GAP) for Gsp1p, involved in nuclear transport	rRNA metabolic process|ribosomal subunit export from nucleus|tRNA metabolic process|rRNA export from nucleus|RNA import into nucleus|protein import into nucleus|chromatin silencing at telomere	Ran GTPase activator activity	cytosol|integral to membrane|nucleus
YNL308C	YNL308C	KRI1	het	Verified	0.760483933214623	0.22348268475336	no	221	0.228913347198695	794	0.010	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Essential nucleolar protein required for 40S ribosome biogenesis; associate with snR30; physically and functionally interacts with Krr1p	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	nucleolus
YLL035W	YLL035W	GRC3	het	Verified	0.750326733803076	0.226528972654647	no	222	0.203720737559707	707	0.012	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS|CHROMOSOME		Polynucleotide kinase present on rDNA that is required for efficient transcription termination by RNA polymerase I; required for cell growth; mRNA is cell-cycle regulated	termination of RNA polymerase I transcription|rRNA processing	polynucleotide 5'-hydroxyl-kinase activity	nucleolar chromatin
YMR117C	YMR117C	SPC24	het	Verified	0.738066646422726	0.230236975345639	no	223	0.181119654647508	639	0.003	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME	KINETOCHORE	Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering	microtubule nucleation|chromosome segregation	structural constituent of cytoskeleton	Ndc80 complex|condensed nuclear chromosome kinetochore|condensed nuclear chromosome, centromeric region
YDR396W_d	YDR396W	YDR396W	het	Dubious	0.735403003183202	0.231047046698862	no	224	0.252014912659379	855	0.000					Dubious open reading frame unlikely to encode a functional protein; extensively overlaps essential NCB2 gene encoding the beta subunit of the NC2 dimeric histone-fold complex	Unknown	Unknown	Unknown
YJR045C	YJR045C	SSC1	het	Verified	0.735087296364851	0.231143165288963	no	225	0.217692774084019	737	0.007	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION	NUCLEUS|MITOCHONDRION		Hsp70 family ATPase; constituent of the import motor component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein translocation and folding; subunit of SceI endonuclease; SSC1 has a paralog, ECM10, that arose from the whole genome duplication	protein refolding|positive regulation of endodeoxyribonuclease activity|protein import into mitochondrial matrix|protein unfolding	enzyme regulator activity|ATPase activity	mitochondrial nucleoid|mitochondrion|TRC complex|mitochondrial inner membrane|presequence translocase-associated import motor
YLR008C	YLR008C	PAM18	het	Verified	0.727704676034762	0.233397193654832	no	226	0.203790378303607	680	0.002	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Constituent of the import motor (PAM complex) component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); essential J-protein cochaperone that stimulates Ssc1p ATPase activity to drive import; inhibited by Pam16p	protein import into mitochondrial matrix	unfolded protein binding|ATPase activator activity	mitochondrion|presequence translocase-associated import motor|mitochondrial inner membrane presequence translocase complex
YNL132W	YNL132W	KRE33	het	Verified	0.725662189581776	0.234022943181039	no	227	0.229700226086462	784	0.006	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS	NUCLEUS		Essential protein, required for biogenesis of the small ribosomal subunit; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance	ribosomal small subunit biogenesis	molecular_function	nucleolus|90S preribosome
YOR262W	YOR262W	GPN2	het	Verified	0.71986386477383	0.235804409234084	no	228	0.237966537004376	819	0.005	FT	PROTEIN LOCALIZATION|CELL CYCLE|CHROMOSOME SEGREGATION			Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn3p; highly conserved across species and homologous to human gene GPN2/ATPBD1B; required for establishment of sister chromatid cohesion	establishment of mitotic sister chromatid cohesion	molecular_function	cytoplasm
YMR112C	YMR112C	MED11	het	Verified	0.714658312057621	0.237410101641453	no	229	0.184681648225153	640	0.002	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RNA POL II, HOLOENZYME	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential protein	negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter	TFIIH-class transcription factor binding|TFIIH-class transcription factor recruiting transcription factor activity	core mediator complex
YDR355C_d	YDR355C	YDR355C	het	Dubious	0.71303647471947	0.237911593467083	no	230	0.202438886981405	664	0.005					Dubious: Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified essential ORF SPC110/YDR356W	Unknown	Unknown	Unknown
YIR006C	YIR006C	PAN1	het	Verified	0.707687819414296	0.239569571604965	no	231	0.20773657438603	713	0.002	FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION|CYTOSKELETON ORGANIZATION	NUCLEUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON		Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p, associates with actin patches on the cell cortex; promotes protein-protein interactions essential for endocytosis; binds to and activates the Arp2/3 complex in vitro; previously thought to be a subunit of poly(A) ribonuclease	bipolar cellular bud site selection|endocytosis|axial cellular bud site selection|cytokinesis|actin cortical patch assembly	protein binding, bridging	nucleus|plasma membrane|mating projection tip|cytoplasm|actin cortical patch
YGR195W	YGR195W	SKI6	het	Verified	0.705370781487582	0.240289761140923	no	232	0.217212347302533	733	0.000	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4)	nuclear mRNA surveillance|U5 snRNA 3'-end processing|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent CUT catabolic process|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear polyadenylation-dependent mRNA catabolic process|nonfunctional rRNA decay|U4 snRNA 3'-end processing|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|rRNA catabolic process|polyadenylation-dependent snoRNA 3'-end processing|U1 snRNA 3'-end processing|nuclear-transcribed mRNA catabolic process, non-stop decay|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)
YNL088W	YNL088W	TOP2	het	Verified	0.704872518127599	0.24044478700432	no	233	0.232845032065286	785	0.000	FT	CELL CYCLE|CHROMATIN ORGANIZATION|CHROMOSOME SEGREGATION	NUCLEUS|MITOCHONDRION|CHROMOSOME		Topoisomerase II, relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis; required for replication slow zone (RSZ) breakage following Mec1p inactivation	chromatin assembly or disassembly|chromatin remodeling at centromere|replication fork progression beyond termination site|mitotic cell cycle G2/M transition decatenation checkpoint|DNA topological change|DNA strand elongation involved in DNA replication|regulation of mitotic recombination|reciprocal meiotic recombination	DNA topoisomerase (ATP-hydrolyzing) activity	DNA replication termination region|synaptonemal complex|mitochondrion|nucleus
YDR416W	YDR416W	SYF1	het	Verified	0.704376708720814	0.240599103418348	no	234	0.189057332285762	637	0.001	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING	NUCLEUS		Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; null mutant has splicing defect and arrests in G2/M; homologs in human and C. elegans	generation of catalytic spliceosome for first transesterification step	first spliceosomal transesterification activity|second spliceosomal transesterification activity	U2-type post-mRNA release spliceosomal complex|Prp19 complex|U2-type prespliceosome|U2-type catalytic step 1 spliceosome|U2-type catalytic step 2 spliceosome
YMR213W	YMR213W	CEF1	het	Verified	0.703713236343212	0.240805687812528	no	235	0.213078254646751	719	0.002	FT	CELL CYCLE|RNA PROCESSING	NUCLEUS		Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p	mRNA splicing, via spliceosome	first spliceosomal transesterification activity	Prp19 complex|U2-type catalytic step 1 spliceosome
YLR298C	YLR298C	YHC1	het	Verified	0.701728815620032	0.241424149525562	no	236	0.229742640102447	779	0.001	FT	RNA PROCESSING	NUCLEUS		Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice site	mRNA splicing, via spliceosome	mRNA binding	commitment complex|U1 snRNP|U2-type prespliceosome
YMR094W	YMR094W	CTF13	het	Verified	0.700277225378401	0.241877095908081	no	237	0.200357783121005	668	0.000	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	NUCLEUS|CHROMOSOME	KINETOCHORE	Subunit of the CBF3 complex, which binds to the CDE III element of centromeres, bending the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis	kinetochore assembly|septin ring assembly	DNA binding, bending|centromeric DNA binding	condensed nuclear chromosome kinetochore|CBF3 complex
YMR028W	YMR028W	TAP42	het	Verified	0.70009117332913	0.241935183900926	no	238	0.223274169469784	739	0.002	FT	SIGNALING			Essential protein involved in the TOR signaling pathway; physically associates with the protein phosphatase 2A and the SIT4 protein phosphatase catalytic subunits	TOR signaling cascade|positive regulation of transcription from RNA polymerase I promoter	molecular_function	cytosol|extrinsic to membrane
YGL150C	YGL150C	INO80	het	Verified	0.698196749076204	0.242527079637162	no	239	0.269788122846443	895	0.000	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS|CHROMOSOME		ATPase and nucleosome spacing factor, subunit of complex containing actin and actin-related proteins that has chromatin remodeling activity and 3' to 5' DNA helicase activity in vitro; has a role in modulating stress gene transcription	nucleosome positioning|histone exchange|transcription from RNA polymerase II promoter|DNA repair|nucleosome mobilization|chromatin remodeling|chromatin silencing at telomere|regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter	ATPase activity|ATP-dependent 3'-5' DNA helicase activity	Ino80 complex
YDR434W	YDR434W	GPI17	het	Verified	0.697919145049001	0.242613880342892	no	240	0.20380539762124	681	0.004	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-S homolog	attachment of GPI anchor to protein	GPI-anchor transamidase activity	integral to membrane|endoplasmic reticulum|GPI-anchor transamidase complex
YER157W	YER157W	COG3	het	Verified	0.693626811975974	0.243958137387064	no	241	0.22414683823652	761	0.010	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments	peroxisome degradation|ER to Golgi vesicle-mediated transport|macroautophagy|retrograde transport, vesicle recycling within Golgi|intra-Golgi vesicle-mediated transport|CVT pathway	protein transporter activity	Golgi transport complex
YPR048W	YPR048W	TAH18	het	Verified	0.683480923540673	0.247151500216102	no	242	0.234172636628779	805	0.006	FT	OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM	MITOCHONDRION		Conserved NAPDH-dependent diflavin reductase; component of an early step in the cytosolic Fe-S protein assembly (CIA) machinery; transfers electrons from NADPH to the Fe-S cluster of Dre2p; plays a pro-death role under oxidative stress; Tah18p-dependent nitric oxide synthesis confers high-temperature stress tolerance	oxidation-reduction process|iron-sulfur cluster assembly	oxidoreductase activity, acting on NADH or NADPH	mitochondrion
YNL062C	YNL062C	GCD10	het	Verified	0.677032806950676	0.249192569687781	no	243	0.282486159087348	960	0.003	FT	RNA PROCESSING|TRANSLATION	NUCLEUS		Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression	tRNA methylation	tRNA (adenine-N1-)-methyltransferase activity	tRNA (m1A) methyltransferase complex|nucleus
YJL173C	YJL173C	RFA3	het	Verified	0.674490295112401	0.249999826838392	no	244	0.244982242973543	822	0.004	FT	PROTEIN LOCALIZATION|CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein complex involved in DNA replication, repair, and recombination; protein abundance increases in response to DNA replication stress	establishment of protein localization|telomere maintenance via telomerase|telomere maintenance via recombination|nucleotide-excision repair|DNA repair|mitotic recombination|heteroduplex formation|DNA unwinding involved in replication|reciprocal meiotic recombination|double-strand break repair via homologous recombination|DNA replication|protein ubiquitination	double-stranded DNA binding|sequence-specific DNA binding	condensed nuclear chromosome|chromosome, telomeric region|DNA replication factor A complex
YJR017C	YJR017C	ESS1	het	Verified	0.670969228224191	0.251120066397854	no	245	0.238115404160618	779	0.005	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CHROMATIN ORGANIZATION|PROTEOLYSIS|GENE SILENCING	NUCLEUS		Peptidylprolyl-cis/trans-isomerase (PPIase); specific for phosphorylated serine and threonine residues N-terminal to proline; regulates phosphorylation of the RNAP II large subunit (Rpo21p) C-terminal domain (CTD); associates with phospho-Ser5 form of RNAP II in vivo; regulates phosphorylation of Ser7 within CTD; present along entire coding length of genes; represses initiation of CUTs; required for efficient termination of mRNA transcription and trimethylation of histone H3	termination of RNA polymerase II transcription|positive regulation of protein dephosphorylation|negative regulation of histone deacetylation|negative regulation of transcription from RNA polymerase II promoter|protein peptidyl-prolyl isomerization|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|Unknown|regulation of transcription involved in G1 phase of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription involved in G2/M-phase of mitotic cell cycle	peptidyl-prolyl cis-trans isomerase activity|RNA polymerase II core binding	nucleus
YLL003W	YLL003W	SFI1	het	Verified	0.665639368235357	0.252820818325428	no	246	0.235369539294896	781	0.000	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION	CYTOSKELETON		Centrin (Cdc31p)-binding protein required for spindle pole body (SPB) duplication, localizes to the half-bridge of the SPB, required for progression through G(2)-M transition, has similarity to Xenopus laevis XCAP-C	G2/M transition of mitotic cell cycle|spindle assembly|spindle pole body duplication associated with nuclear envelope	molecular_function	half bridge of spindle pole body
YGL073W	YGL073W	HSF1	het	Verified	0.665545044127819	0.252850971547284	no	247	0.220997156910087	745	0.000	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|SIGNALING|CYTOSKELETON ORGANIZATION	NUCLEUS|MITOCHONDRION		Trimeric heat shock transcription factor, activates multiple genes in response to stresses that include hyperthermia; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; posttranslationally regulated	spindle pole body duplication|negative regulation of TOR signaling cascade|response to heat|regulation of transcription from RNA polymerase II promoter|response to stress	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	mitochondrion|nucleus
YPL190C	YPL190C	NAB3	het	Verified	0.665466751447796	0.252876001332616	no	248	0.240762204889135	838	0.000	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3′ end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; required for termination of non-poly(A) transcripts and efficient splicing	nuclear mRNA surveillance|mRNA 3'-end processing|antisense RNA transcript catabolic process|CUT catabolic process|termination of RNA polymerase II transcription, exosome-dependent|tRNA 3'-end processing|snRNA 3'-end processing|snoRNA 3'-end processing	RNA binding|transcription regulatory region RNA binding	Nrd1 complex|nucleus
YJL050W	YJL050W	MTR4	het	Verified	0.66527052548687	0.252938739538759	no	249	0.240224122087666	839	0.005	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|OXIDATION-REDUCTION PROCESS|RNA LOCALIZATION	NUCLEUS		ATP-dependent 3'-5' RNA helicase of the DExD/H family; involved in nuclear RNA processing and degradation both as a component of TRAMP complex and in TRAMP-independent processes; TRAMP unwinds RNA duplexes, with Mtr4p unwinding activity stimulated by Pap2p/Air2p but not dependent on ongoing polyadenylation; contains an arch domain, with two coiled-coil arms/stalks and a globular fist/KOW domain, which has RNA binding activity and is required for 5.8S rRNA processing	U5 snRNA 3'-end processing|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|ncRNA polyadenylation|nuclear polyadenylation-dependent mRNA catabolic process|U4 snRNA 3'-end processing|nuclear mRNA surveillance of mRNA 3'-end processing|nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription|rRNA catabolic process|polyadenylation-dependent snoRNA 3'-end processing|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	ATP-dependent 3'-5' RNA helicase activity|poly(A) RNA binding	nucleolus|nucleus|TRAMP complex
YML046W	YML046W	PRP39	het	Verified	0.660106410207432	0.254592772686406	no	250	0.217076025427402	745	0.002	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING	NUCLEUS		U1 snRNP protein involved in splicing, contains multiple tetriatricopeptide repeats	mRNA 5'-splice site recognition	pre-mRNA 5'-splice site binding	commitment complex|U1 snRNP|U2-type prespliceosome
YOL123W	YOL123W	HRP1	het	Verified	0.658418855587707	0.255134511276833	no	251	0.235026231287001	771	0.003	FT	RNA PROCESSING	NUCLEUS		Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences	mRNA cleavage|mRNA polyadenylation	mRNA binding|RNA binding	mRNA cleavage factor complex|nucleus|cytoplasmic stress granule|cytoplasm
YKL193C	YKL193C	SDS22	het	Verified	0.65548196331044	0.256078747711266	no	252	0.239638466989118	776	0.004	FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS		Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p; whether it functions as a positive or negative regulator of Glc7p is controversial; involved in the regulation of Glc7p nuclear localization and function	maintenance of protein location in nucleus|chromosome segregation	protein serine/threonine phosphatase inhibitor activity|protein phosphatase type 1 activator activity	protein phosphatase type 1 complex|nucleus|cytoplasm
YHR170W	YHR170W	NMD3	het	Verified	0.651452288565512	0.257377283224305	no	253	0.326742205951022	1129	0.001	FF|FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS	NUCLEUS	RIBOSOME	Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex	ribosomal large subunit export from nucleus	ribosomal large subunit binding	cytosol|cytosolic large ribosomal subunit
YDR087C	YDR087C	RRP1	het	Verified	0.650489774068684	0.257687952501954	no	254	0.259451837470449	877	0.002	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Essential evolutionarily conserved nucleolar protein necessary for biogenesis of 60S ribosomal subunits and processing of pre-rRNAs to mature rRNAs, associated with several distinct 66S pre-ribosomal particles	rRNA processing	molecular_function	nucleolus|nucleus|preribosome, large subunit precursor
YBL035C	YBL035C	POL12	het	Verified	0.648275936719079	0.258403247432797	no	255	0.220464930631335	772	0.009	FT		ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME		B subunit of DNA polymerase alpha-primase complex, required for initiation of DNA replication during mitotic and premeiotic DNA synthesis; also functions in telomere capping and length regulation	telomere capping|lagging strand elongation|DNA replication initiation	DNA-directed DNA polymerase activity	nuclear envelope|alpha DNA polymerase:primase complex|nucleus
YDL008W	YDL008W	APC11	het	Verified	0.638829468815522	0.261466937680725	no	256	0.23539377727067	774	0.003	FT	CELL CYCLE|CELL DIVISION|PROTEOLYSIS	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; contains a RING-H2 domain that is required for activity	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination	ubiquitin-protein ligase activity	anaphase-promoting complex
YOR095C	YOR095C	RKI1	het	Verified	0.635705215454493	0.2624842882051	no	257	0.245589617702305	815	0.002	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Ribose-5-phosphate ketol-isomerase, catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway; participates in pyridoxine biosynthesis	pyridoxine biosynthetic process|pentose-phosphate shunt	ribose-5-phosphate isomerase activity	nucleus|cytoplasm
YNL181W_p	YNL181W	YNL181W	het	Uncharacterized	0.634031362951132	0.263030177206893	no	258	0.225051527810064	781	0.002	FT	OXIDATION-REDUCTION PROCESS	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Putative oxidoreductase; required for cell viability	biological_process	oxidoreductase activity|oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor	nuclear envelope|endoplasmic reticulum
YBR060C	YBR060C	ORC2	het	Verified	0.631670643809708	0.263801057194917	no	259	0.261970403790227	916	0.000	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; interacts with Spp1p and with trimethylated histone H3; phosphorylated by Cdc28p	histone H3-K4 methylation|DNA replication initiation|pre-replicative complex assembly|chromatin silencing at silent mating-type cassette|chromatin silencing at telomere	chromatin binding|DNA replication origin binding	DNA replication preinitiation complex|pre-replicative complex|nuclear origin of replication recognition complex
YGL171W	YGL171W	ROK1	het	Verified	0.631274539661853	0.263930515624447	no	260	0.261231346432274	901	0.002	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|RNA LOCALIZATION	NUCLEUS		RNA-dependent ATPase; involved in pre-rRNA processing at sites A0, A1, and A2, and in control of cell cycle progression; contains two upstream open reading frames (uORFs) in 5' untranslated region which regulate translation	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|snoRNA localization	RNA-dependent ATPase activity	nucleolus|90S preribosome
YMR113W	YMR113W	FOL3	het	Verified	0.629440788488977	0.264530260860875	no	261	0.26008037269067	893	0.000	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM			Dihydrofolate synthetase, involved in folic acid biosynthesis; catalyzes the conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis	folic acid-containing compound biosynthetic process	dihydrofolate synthase activity	cytoplasm
YJL039C	YJL039C	NUP192	het	Verified	0.628990855774499	0.264677521376661	no	262	0.278583067882881	945	0.005	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Essential subunit of the inner ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport; homologous to human NUP205	nucleocytoplasmic transport|nuclear pore organization	structural constituent of nuclear pore	integral to membrane|nuclear pore nuclear basket|nuclear pore|nuclear pore inner ring
YNL263C	YNL263C	YIF1	het	Verified	0.624465908019395	0.26616082643818	no	263	0.255793102178184	825	0.001	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Integral membrane protein required for the fusion of ER-derived COPII transport vesicles with the Golgi; interacts with Yip1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; homolog of human YIPF3	ER to Golgi vesicle-mediated transport	molecular_function	integral to membrane|integral to Golgi membrane|endoplasmic reticulum membrane|ER to Golgi transport vesicle
YFR051C	YFR051C	RET2	het	Verified	0.62373121515608	0.266402059730845	no	264	0.264582275280285	922	0.005	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER	retrograde vesicle-mediated transport, Golgi to ER|Golgi inheritance|ER to Golgi vesicle-mediated transport|Golgi localization	molecular_function	COPI vesicle coat
YKL192C	YKL192C	ACP1	het	Verified	0.618346398247157	0.268173511527907	no	265	0.255874512252955	870	0.005	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial matrix acyl carrier protein, involved in biosynthesis of octanoate, which is a precursor to lipoic acid; activated by phosphopantetheinylation catalyzed by Ppt2p	lipoate biosynthetic process	ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process	mitochondrion
YIL104C	YIL104C	SHQ1	het	Verified	0.613839430789288	0.269660719064952	no	266	0.251286436936481	838	0.005	FT	PROTEIN COMPLEX ORG/BIOGENESIS	NUCLEUS		Chaperone protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Naf1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; homology with known Hsp90p cochaperones	box H/ACA snoRNP assembly	unfolded protein binding	nucleoplasm
YMR208W	YMR208W	ERG12	het	Verified	0.609246037986854	0.271180684481174	no	267	0.302655928104234	1043	0.002	FF|FT	LIPID METABOLISM|COFACTOR METABOLISM			Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate	ergosterol biosynthetic process|isopentenyl diphosphate biosynthetic process, mevalonate pathway|farnesyl diphosphate biosynthetic process, mevalonate pathway	mevalonate kinase activity	cytosol
YPR010C	YPR010C	RPA135	het	Verified	0.607270608701001	0.271835670103036	no	268	0.25440463707585	887	0.002	FT		NUCLEUS		RNA polymerase I second largest subunit A135	transcription of nuclear large rRNA transcript from RNA polymerase I promoter	DNA-directed RNA polymerase activity	DNA-directed RNA polymerase I complex
YNL306W	YNL306W	MRPS18	het	Verified	0.605007855249896	0.272586888666593	no	269	0.250104394528993	861	0.002	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit; essential for viability, unlike most other mitoribosomal proteins	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YEL026W	YEL026W	SNU13	het	Verified	0.602561746515453	0.273400137421811	no	270	0.253238716352027	876	0.003	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		RNA binding protein, part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|mRNA splicing, via spliceosome	RNA binding	box C/D snoRNP complex|small-subunit processome|nucleolus|U4/U6 x U5 tri-snRNP complex
YGR013W	YGR013W	SNU71	het	Verified	0.599415000040848	0.274448088333367	no	271	0.269798116997304	929	0.000	FT	RNA PROCESSING	NUCLEUS		Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart	mRNA splicing, via spliceosome	RNA binding	U1 snRNP|U2-type prespliceosome
YDR166C	YDR166C	SEC5	het	Verified	0.599339241736271	0.274473342295761	no	272	0.269259384089811	922	0.003	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION	SITE OF POLARIZED GROWTH		Essential 107kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in assembly of the exocyst complex; required with Sec3p for ER inheritance where it promotes anchoring of the cortical ER at the bud tip	Golgi to plasma membrane transport|endoplasmic reticulum inheritance|exocytosis|exocyst assembly|vesicle fusion|vesicle docking involved in exocytosis	molecular_function	incipient cellular bud site|mating projection tip|cellular bud neck|exocyst|cellular bud tip
YDR460W	YDR460W	TFB3	het	Verified	0.596387853062878	0.275458076634806	no	273	0.266295698726202	886	0.001	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION	NUCLEUS	RNA POL II, HOLOENZYME	Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair; ring finger protein similar to mammalian CAK and TFIIH subunit	phosphorylation of RNA polymerase II C-terminal domain|nucleotide-excision repair|transcription from RNA polymerase II promoter	core RNA polymerase binding transcription factor activity	holo TFIIH complex|TFIIK complex
YLR397C	YLR397C	AFG2	het	Verified	0.595450201176505	0.275771288690879	no	274	0.25446266064871	874	0.003	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS			ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex; is essential for pre-60S maturation and release of several preribosome maturation factors; releases Rlp24p from purified pre-60S particles in vitro; may be involved in degradation of aberrant mRNAs	ribosomal large subunit biogenesis|response to drug	ATPase activity	intracellular|preribosome, large subunit precursor
YJL074C	YJL074C	SMC3	het	Verified	0.592622083998464	0.276717048128926	no	275	0.233223227582202	828	0.003	FT	CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Subunit of the multiprotein cohesin complex required for sister chromatid cohesion in mitotic cells; also required, with Rec8p, for cohesion and recombination during meiosis; phylogenetically conserved SMC chromosomal ATPase family member	synaptonemal complex assembly|ascospore formation|reciprocal meiotic recombination|mitotic sister chromatid cohesion|meiotic sister chromatid cohesion	ATPase activity	nucleus|nuclear mitotic cohesin complex
YER038C	YER038C	KRE29	het	Verified	0.589211902561253	0.27785956681861	no	276	0.26801610855608	901	0.004	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Subunit of the SMC5-SMC6 complex; this complex is involved in removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance	DNA repair	molecular_function	Smc5-Smc6 complex|nucleus|cytoplasm
YIL109C	YIL109C	SEC24	het	Verified	0.585436581263911	0.279127098797635	no	277	0.244418957853989	843	0.001	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sfb2p and Sfb3p	cargo loading into COPII-coated vesicle	signal sequence binding	COPII vesicle coat
YLR430W	YLR430W	SEN1	het	Verified	0.584306374753425	0.279507102029098	no	278	0.301242381137923	1030	0.001	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Presumed helicase and subunit of the Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3' end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; has a separate role in coordinating DNA replication with transcription, by associating with moving replication forks and preventing errors that occur when forks encounter transcribed regions; homolog of Senataxin, which is implicated in Ataxia-Oculomotor Apraxia 2 and a dominant form of ALS	tRNA processing|mRNA 3'-end processing|termination of RNA polymerase II transcription|mRNA polyadenylation|snoRNA 3'-end processing|rRNA processing|snRNA processing	ATP-dependent 5'-3' DNA helicase activity|DNA-dependent ATPase activity|RNA-dependent ATPase activity|ATP-dependent 5'-3' RNA helicase activity|protein domain specific binding	Nrd1 complex|nucleus
YKR086W	YKR086W	PRP16	het	Verified	0.583550655389653	0.279761333534647	no	279	0.258425135616491	878	0.001	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING	NUCLEUS		DEAH-box RNA helicase involved in second catalytic step of splicing; exhibits ATP-dependent RNA unwinding activity; mediates the release of Yju2p and Cwc25p in the second step; in the absence of ATP, stabilizes the binding of Cwc25p to the spliceosome in the first catalytic step	generation of catalytic spliceosome for second transesterification step	second spliceosomal transesterification activity|RNA-dependent ATPase activity	U2-type catalytic step 2 spliceosome
YDR487C	YDR487C	RIB3	het	Verified	0.58280243587761	0.28001315249296	no	280	0.273418733143568	897	0.001	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase), required for riboflavin biosynthesis from ribulose-5-phosphate, also has an unrelated function in mitochondrial respiration	riboflavin biosynthetic process|aerobic respiration	3,4-dihydroxy-2-butanone-4-phosphate synthase activity	cytosol|mitochondrial intermembrane space
YBR055C	YBR055C	PRP6	het	Verified	0.581394445013416	0.280487320243508	no	281	0.2824009648978	934	0.000	FT	RNA PROCESSING	NUCLEUS		Splicing factor, component of the U4/U6-U5 snRNP complex	mRNA splicing, via spliceosome	molecular_function	U4/U6 x U5 tri-snRNP complex
YDL064W	YDL064W	UBC9	het	Verified	0.58090707704445	0.280651541193574	no	282	0.261744962215862	865	0.002	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION	NUCLEUS|CHROMOSOME		SUMO-conjugating enzyme involved in the Smt3p conjugation pathway; nuclear protein required for S- and M-phase cyclin degradation and mitotic control; involved in proteolysis mediated by the anaphase-promoting complex cyclosome (APCC)	G2/M transition of mitotic cell cycle|protein sumoylation|mitotic spindle elongation	SUMO ligase activity	condensed nuclear chromosome|nucleus
YIL003W	YIL003W	CFD1	het	Verified	0.579308554089851	0.281190497328784	no	283	0.212166739137176	743	0.000	FT	RNA PROCESSING|COFACTOR METABOLISM			Highly conserved, iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Nbp35p that is involved in iron-sulfur protein assembly in the cytosol	iron-sulfur cluster assembly|tRNA wobble uridine modification	4 iron, 4 sulfur cluster binding|ATPase activity	cytoplasm
YFR050C	YFR050C	PRE4	het	Verified	0.579181256932461	0.281233438166935	no	284	0.303399492639807	1069	0.001	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Beta 7 subunit of the 20S proteasome	proteasome assembly|proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process	molecular_function	nucleus|proteasome storage granule|endoplasmic reticulum membrane|proteasome core complex, beta-subunit complex
YLR276C	YLR276C	DBP9	het	Verified	0.577817391409297	0.281693706165165	no	285	0.255860469557198	862	0.003	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		DEAD-box protein required for 27S rRNA processing; exhibits DNA, RNA and DNA/RNA helicase activities; ATPase activity shows preference for DNA over RNA; DNA helicase activity abolished by mutation in RNA-binding domain	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	ATP-dependent DNA helicase activity|ATP-dependent DNA/RNA helicase activity|ATP-dependent RNA helicase activity	nucleolus
YJL033W	YJL033W	HCA4	het	Verified	0.575296944684865	0.282545243753222	no	286	0.245877088039121	822	0.002	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis	rRNA processing	RNA-dependent ATPase activity|ATP-dependent RNA helicase activity	nucleolus
YNL247W	YNL247W	YNL247W	het	Verified	0.573015809554566	0.283316994793232	no	287	0.286027150019929	974	0.002	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION			Cysteinyl-tRNA synthetase; may interact with ribosomes, based on co-purification experiments	cysteinyl-tRNA aminoacylation	cysteine-tRNA ligase activity	ribosome|cytoplasm
YFL017C	YFL017C	GNA1	het	Verified	0.571290851778833	0.283901250953841	no	288	0.279846389657295	949	0.003	FT	CARBOHYDRATE METABOLISM	NUCLEUS		Evolutionarily conserved glucosamine-6-phosphate acetyltransferase required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA	UDP-N-acetylglucosamine biosynthetic process	glucosamine 6-phosphate N-acetyltransferase activity	nucleus|cytoplasm
YLR153C	YLR153C	ACS2	het	Verified	0.567797839621246	0.285086123471588	no	289	0.312175894978144	1035	0.003	FT	CHROMATIN ORGANIZATION|COFACTOR METABOLISM	NUCLEUS		Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions	histone acetylation|acetyl-CoA biosynthetic process|replicative cell aging	acetate-CoA ligase activity|acid-ammonia (or amide) ligase activity	cytosol|nucleolus|nucleus
YDR086C	YDR086C	SSS1	het	Verified	0.564894665138561	0.286072706272484	no	290	0.24783721879435	857	0.003	FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p	posttranslational protein targeting to membrane, translocation|SRP-dependent cotranslational protein targeting to membrane, translocation	structural molecule activity|P-P-bond-hydrolysis-driven protein transmembrane transporter activity	Sec61 translocon complex|Ssh1 translocon complex
YOR370C	YOR370C	MRS6	het	Verified	0.561953270412155	0.287073928821794	no	291	0.243811297010263	845	0.001	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM|PROTEIN PRENYLATION			Rab escort protein; forms a complex with the Ras-like small GTPase Ypt1p that is required for the prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p); sequence similarity to mammalian choroideraemia gene; relative distribution to the nucleus increases upon DNA replication stress	protein targeting to membrane|protein geranylgeranylation|ER to Golgi vesicle-mediated transport|activation of Rab GTPase activity	Rab geranylgeranyltransferase activity|Rab GTPase binding	Rab-protein geranylgeranyltransferase complex|membrane|cytoplasm
YAL034W-A	YAL034W-A	MTW1	het	Verified	0.561203460843646	0.287329421968451	no	292	0.268187385206778	916	0.007	FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME|CYTOSKELETON	KINETOCHORE	Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly	chromosome segregation|protein localization to kinetochore	molecular_function	nuclear MIS12/MIND type complex|spindle pole
YPL218W	YPL218W	SAR1	het	Verified	0.55468756207995	0.289554192560556	no	293	0.281553713668701	944	0.004	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		GTPase, GTP-binding protein of the ARF family, component of COPII coat of vesicles; required for transport vesicle formation during ER to Golgi protein transport	regulation of COPII vesicle coating	GTPase activity	COPII vesicle coat
YJL019W	YJL019W	MPS3	het	Verified	0.551179315268549	0.29075537909349	no	294	0.263496327962787	917	0.002	FT	CELL CYCLE|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME|CYTOSKELETON		Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p	meiotic telomere clustering|synapsis|nuclear migration involved in conjugation with cellular fusion|spindle pole body duplication associated with nuclear envelope|telomere tethering at nuclear periphery|mitotic sister chromatid cohesion	molecular_function	nuclear envelope|nuclear periphery|integral to membrane|nuclear chromosome, telomeric region|half bridge of spindle pole body
YKR004C	YKR004C	ECM9	het	Verified	0.54961771771345	0.291290801929549	no	295	0.312980542082057	1044	0.010	FT	CELL WALL ORG/BIOGENESIS			Non-essential protein of unknown function	fungal-type cell wall organization	molecular_function	cellular_component
YLR379W_d	YLR379W	YLR379W	het	Dubious	0.539988537173854	0.294602468816733	no	296	0.307469923044748	1026	0.000					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential ORF SEC61/YLR378C	Unknown	Unknown	Unknown
YMR079W	YMR079W	SEC14	het	Verified	0.539553315568082	0.29475255962129	no	297	0.307158622288578	1033	0.006	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; has a role in localization of lipid raft proteins; functionally homologous to mammalian PITPs	Golgi vesicle budding|phosphatidylinositol metabolic process|Golgi to plasma membrane protein transport|Golgi to vacuole transport|ascospore formation|Unknown|phospholipid transport	phosphatidylinositol transporter activity|phosphatidylcholine transporter activity	cytosol|Golgi apparatus|Golgi membrane|cytoplasm
YMR277W	YMR277W	FCP1	het	Verified	0.533279086582634	0.296920201174673	no	298	0.32584093150514	1100	0.004	FF|FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Carboxy-terminal domain (CTD) phosphatase, essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p)	dephosphorylation of RNA polymerase II C-terminal domain|regulation of transcription from RNA polymerase II promoter	protein serine/threonine phosphatase activity	nucleus
YDR228C	YDR228C	PCF11	het	Verified	0.529066315989838	0.298379723555758	no	299	0.305340660507472	1049	0.003	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		mRNA 3' end processing factor, essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II (Rpo21p); required for gene looping	mRNA cleavage|termination of RNA polymerase II transcription|mRNA polyadenylation	mRNA binding|RNA polymerase II core binding	mRNA cleavage factor complex
YBL073W_d	YBL073W	YBL073W	het	Dubious	0.526470111556177	0.299280806620111	no	300	0.285251926685767	978	0.005					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene AAR2/YBL074C	Unknown	Unknown	Unknown
YKL189W	YKL189W	HYM1	het	Verified	0.521643893890625	0.300959147880455	no	301	0.243682057385165	800	0.002	FT	CELL DIVISION	SITE OF POLARIZED GROWTH		Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response	cytokinesis, completion of separation|regulation of cell shape|regulation of transcription, DNA-dependent|budding cell apical bud growth	molecular_function	incipient cellular bud site|intracellular|cellular bud|mating projection tip
YPR056W	YPR056W	TFB4	het	Verified	0.519253741173314	0.301791903602856	no	302	0.284877785383707	957	0.002	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION	NUCLEUS	RNA POL II, HOLOENZYME	Subunit of TFIIH complex, involved in transcription initiation, similar to 34 kDa subunit of human TFIIH; interacts with Ssl1p	phosphorylation of RNA polymerase II C-terminal domain|nucleotide-excision repair|transcription from RNA polymerase II promoter	core RNA polymerase binding transcription factor activity	core TFIIH complex|holo TFIIH complex|nucleotide-excision repair factor 3 complex
YCL052C	YCL052C	PBN1	het	Verified	0.517269125533454	0.3024841517131	no	303	0.305319205393379	1012	0.006	FT	LIPID METABOLISM|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Essential component of glycosylphosphatidylinositol-mannosyltransferase I, required for the autocatalytic post-translational processing of the protease B precursor Prb1p, localizes to ER in lumenal orientation; homolog of mammalian PIG-X	GPI anchor biosynthetic process|ER-associated protein catabolic process|protein processing	mannosyltransferase activity	endoplasmic reticulum
YOR103C	YOR103C	OST2	het	Verified	0.51113890737667	0.304626896820397	no	304	0.313114747031853	1077	0.003	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins	protein N-linked glycosylation	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	oligosaccharyltransferase complex|integral to membrane
YDR288W	YDR288W	NSE3	het	Verified	0.508620363538457	0.305509176251725	no	305	0.331873691457806	1116	0.004	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; protein abundance increases in response to DNA replication stress	DNA repair	DNA binding	Smc5-Smc6 complex|nucleus|cytoplasm
YCL043C	YCL043C	PDI1	het	Verified	0.50428053824571	0.30703212579859	no	306	0.296958315136022	1011	0.004	FT		ENDOPLASMIC RETICULUM		Protein disulfide isomerase; multifunctional protein of ER lumen, essential for formation of disulfide bonds in secretory and cell-surface proteins, unscrambles non-native disulfide bonds; key regulator of Ero1p; forms complex with Mnl1p that has exomannosidase activity, processing unfolded protein-bound Man8GlcNAc2 oligosaccharides to Man7GlcNAc2, promoting degradation in unfolded protein response; PDI1 has a paralog, EUG1, that arose from the whole genome duplication	protein folding	protein disulfide oxidoreductase activity|protein disulfide isomerase activity	endoplasmic reticulum lumen
YGL225W	YGL225W	VRG4	het	Verified	0.500726983920817	0.308281639428381	no	307	0.329347317687128	1128	0.004	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS		Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi	GDP-mannose transport	GDP-mannose transmembrane transporter activity	mitochondrion|integral to membrane|Golgi apparatus
YLR438C-A	YLR438C-A	LSM3	het	Verified	0.496541808992435	0.309756098644955	no	308	0.309885743988266	1052	0.010	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress	nuclear-transcribed mRNA catabolic process|mRNA splicing, via spliceosome	RNA binding	U6 snRNP|nucleolus|small nucleolar ribonucleoprotein complex|U4/U6 x U5 tri-snRNP complex
YKL112W	YKL112W	ABF1	het	Verified	0.486204696891571	0.313411020778093	no	309	0.333240328757899	1116	0.004	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS		DNA binding protein with possible chromatin-reorganizing activity involved in transcriptional activation, gene silencing, and DNA replication and repair	negative regulation of transcription from RNA polymerase II promoter|global genome nucleotide-excision repair|chromatin remodeling|DNA-dependent DNA replication|positive regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette	DNA replication origin binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding, bending	nucleotide-excision repair factor 4 complex|nucleus
YAL003W	YAL003W	EFB1	het	Verified	0.482473106934536	0.314734949130456	no	310	0.292053848907531	990	0.005	FT	TRANSLATION		RIBOSOME	Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site	translational elongation	translation elongation factor activity|guanyl-nucleotide exchange factor activity	ribosome|eukaryotic translation elongation factor 1 complex
YDL098C	YDL098C	SNU23	het	Verified	0.477622669773809	0.316459396376367	no	311	0.3198193563204	1087	0.003	FT	RNA PROCESSING	NUCLEUS		Component of U4/U6.U5 snRNP involved in mRNA splicing via spliceosome	mRNA splicing, via spliceosome	molecular_function	U4/U6 x U5 tri-snRNP complex
YPL117C	YPL117C	IDI1	het	Verified	0.474571956915214	0.317546049157425	no	312	0.309465877140018	1072	0.000	FT	LIPID METABOLISM	NUCLEUS		Isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IPP isomerase), catalyzes an essential activation step in the isoprenoid biosynthetic pathway; required for viability	farnesyl diphosphate biosynthetic process	isopentenyl-diphosphate delta-isomerase activity	nucleus|cytoplasm
YJL069C	YJL069C	UTP18	het	Verified	0.474568388007025	0.317547321312997	no	313	0.293841021681185	979	0.001	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	small-subunit processome|nucleolus|Pwp2p-containing subcomplex of 90S preribosome|90S preribosome
YOR159C	YOR159C	SME1	het	Verified	0.473180418952997	0.318042233216923	no	314	0.298052545305543	1010	0.006	FT	RNA PROCESSING	NUCLEUS		Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E	mRNA splicing, via spliceosome	molecular_function	U1 snRNP|U2-type prespliceosome|U4/U6 x U5 tri-snRNP complex|U5 snRNP
YGR172C	YGR172C	YIP1	het	Verified	0.466976662463367	0.320258287565968	no	315	0.29117215298575	971	0.004	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Integral membrane protein required for the biogenesis of ER-derived COPII transport vesicles; interacts with Yif1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; homolog of human YIPF4	vesicle-mediated transport|ER to Golgi vesicle-mediated transport|vesicle fusion with Golgi apparatus	molecular_function	integral to membrane|ER to Golgi transport vesicle|integral to Golgi membrane|endoplasmic reticulum membrane
YOR340C	YOR340C	RPA43	het	Verified	0.462596196902115	0.32182691758432	no	316	0.382457081787082	1245	0.002	FF|FT		NUCLEUS		RNA polymerase I subunit A43	transcription of nuclear large rRNA transcript from RNA polymerase I promoter	DNA-directed RNA polymerase activity	DNA-directed RNA polymerase I complex
YOR329C	YOR329C	SCD5	het	Verified	0.460490110127437	0.322582234317532	no	317	0.292094663972287	962	0.000	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION	NUCLEUS|CYTOSKELETON		Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency	protein secretion|endocytosis|actin filament organization|cortical actin cytoskeleton organization	protein phosphatase 1 binding	nucleus|actin cortical patch
YKL059C	YKL059C	MPE1	het	Verified	0.460049795151611	0.322740239458574	no	318	0.325162888738861	1092	0.005	FT	RNA PROCESSING	NUCLEUS		Essential conserved subunit of CPF (cleavage and polyadenylation factor), plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA, contains a putative RNA-binding zinc knuckle motif	mRNA cleavage|mRNA polyadenylation	RNA binding	mRNA cleavage and polyadenylation specificity factor complex
YLR323C	YLR323C	CWC24	het	Verified	0.45480735047017	0.324623920839512	no	319	0.318119496419687	1065	0.002	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING	NUCLEUS		Spliceosome assembly factor, essential for the first step of splicing; component of the pre-catalytic spliceosome complex containing Cef1p; has similarity to S. pombe Cwf24p	generation of catalytic spliceosome for first transesterification step|snoRNA splicing	molecular_function	nucleus|U2-type spliceosomal complex
YKL052C	YKL052C	ASK1	het	Verified	0.452414177608512	0.325485317621065	no	320	0.289806781346978	989	0.001	FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME|CYTOSKELETON	KINETOCHORE	Essential subunit of the Dam1 complex (aka DASH complex); couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; phosphorylated during the cell cycle by cyclin-dependent kinases; protein abundance increases in response to DNA replication stress	attachment of spindle microtubules to kinetochore|attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|mitotic spindle organization in nucleus|regulation of microtubule polymerization or depolymerization|mitotic sister chromatid segregation	microtubule binding|structural constituent of cytoskeleton	condensed nuclear chromosome kinetochore|DASH complex|condensed nuclear chromosome, centromeric region|mitotic spindle
YER036C	YER036C	ARB1	het	Verified	0.450919006969727	0.326023962044441	no	321	0.321830910174123	1058	0.005	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEOTIDE METABOLISM	NUCLEUS		ATPase of the ATP-binding cassette (ABC) family involved in 40S and 60S ribosome biogenesis, has similarity to Gcn20p; shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p	ribosomal small subunit export from nucleus|ribosome biogenesis	ATPase activity, uncoupled	ribosome|nucleus|cytoplasm
YFR027W	YFR027W	ECO1	het	Verified	0.445730030206758	0.327896134796077	no	322	0.301963953994618	1041	0.001	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Acetyltransferase; required for establishment of sister chromatid cohesion; acetylates Mps3p to regulate nuclear organization; modifies Smc3p at replication forks and Mcd1p in response to ds DNA breaks; has a C2H2-type zinc finger; mutations in human homolog ESCO2 cause Roberts syndrome; relative distribution to the nucleus increases upon DNA replication stress	double-strand break repair|regulation of DNA replication|mitotic chromosome condensation|internal peptidyl-lysine acetylation|establishment of mitotic sister chromatid cohesion|DNA repair|chromosome organization|DNA replication|regulation of mitosis|telomere organization|tRNA gene clustering	acetyltransferase activity|chromatin binding	nuclear chromatin|nuclear replication fork
YER133W	YER133W	GLC7	het	Verified	0.444569511302708	0.328315442395361	no	323	0.400796379362855	1334	0.005	FF|FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|CELL DIVISION|CARBOHYDRATE METABOLISM	NUCLEUS|SITE OF POLARIZED GROWTH|CHROMOSOME|CYTOSKELETON	KINETOCHORE	Type 1 serine/threonine protein phosphatase catalytic subunit; involved in various processes including glycogen metabolism, sporulation, mitosis; accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; import into nucleus is inhibited during spindle assembly checkpoint arrest	replication fork processing|glycogen metabolic process|chromosome segregation|regulation of cell shape during vegetative growth phase|termination of RNA polymerase II transcription, poly(A)-coupled|protein dephosphorylation|mitotic cell cycle spindle assembly checkpoint|rRNA processing|regulation of cell cycle|ascospore formation|protein localization to kinetochore|cell budding|DNA damage checkpoint|meiosis|termination of RNA polymerase II transcription, exosome-dependent|DNA replication checkpoint|response to heat|cellular ion homeostasis|histone dephosphorylation|regulation of carbohydrate metabolic process	protein serine/threonine phosphatase activity	protein phosphatase type 1 complex|mating projection base|condensed nuclear chromosome kinetochore|mRNA cleavage and polyadenylation specificity factor complex|nucleolus|spindle pole body|cellular bud neck
YAL032C	YAL032C	PRP45	het	Verified	0.43967995268382	0.330084462116797	no	324	0.332075778590125	1130	0.005	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING	NUCLEUS		Protein required for pre-mRNA splicing; associates with the spliceosome and interacts with splicing factors Prp22p and Prp46p; orthologous to human transcriptional coactivator SKIP and can activate transcription of a reporter gene	generation of catalytic spliceosome for second transesterification step	first spliceosomal transesterification activity|second spliceosomal transesterification activity	nucleus|post-mRNA release spliceosomal complex|U2-type catalytic step 2 spliceosome|U2-type catalytic step 1 spliceosome
YOR020C	YOR020C	HSP10	het	Verified	0.434541363166288	0.331947682430352	no	325	0.327538185761102	1103	0.004	FT		MITOCHONDRION		Mitochondrial matrix co-chaperonin that inhibits the ATPase activity of Hsp60p, a mitochondrial chaperonin; involved in protein folding and sorting in the mitochondria; 10 kD heat shock protein with similarity to E. coli groES	protein folding|protein refolding	unfolded protein binding|chaperone binding	mitochondrion|mitochondrial matrix
YCL059C	YCL059C	KRR1	het	Verified	0.430625613089031	0.333370307224718	no	326	0.304487529375533	1042	0.000	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Essential nucleolar protein required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunit	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal small subunit biogenesis|rRNA processing	molecular_function	small-subunit processome|nucleolus|90S preribosome
YHR065C	YHR065C	RRP3	het	Verified	0.430447220069943	0.333435176218216	no	327	0.307951537390213	1024	0.001	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	RNA-dependent ATPase activity|ATP-dependent RNA helicase activity	nucleolus
YBR160W	YBR160W	CDC28	het	Verified	0.429293384268063	0.33385486537489	no	328	0.320209472435729	1093	0.004	FT	CELL CYCLE|LIPID METABOLISM|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	NUCLEUS|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH|CYTOSKELETON		Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK); alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates; involved in modulating membrane trafficking dynamics; protein abundance increases in response to DNA replication stress	regulation of budding cell apical bud growth|negative regulation of meiotic cell cycle|positive regulation of triglyceride catabolic process|protein phosphorylation|regulation of filamentous growth|negative regulation of transcription, DNA-dependent|positive regulation of meiotic cell cycle|positive regulation of transcription, DNA-dependent|regulation of double-strand break repair via homologous recombination|vesicle-mediated transport|positive regulation of DNA replication involved in S phase|positive regulation of mitotic cell cycle|positive regulation of spindle pole body separation|chromatin remodeling|negative regulation of mitotic cell cycle	histone binding|protein kinase activity|cyclin-dependent protein kinase activity	cyclin-dependent protein kinase holoenzyme complex|ribosome|endoplasmic reticulum|nucleus|spindle pole body|cellular bud neck|astral microtubule|cytoplasm
YKL082C	YKL082C	RRP14	het	Verified	0.425551775623152	0.335217243231527	no	329	0.309969096945138	1047	0.000	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS	RIBOSOME	Essential protein, constituent of 66S pre-ribosomal particles; interacts with proteins involved in ribosomal biogenesis and cell polarity; member of the SURF-6 family	ribosomal small subunit biogenesis|ribosomal large subunit biogenesis	molecular_function	cytosolic large ribosomal subunit|nucleolus
YNL075W	YNL075W	IMP4	het	Verified	0.425059244458016	0.335396743518768	no	330	0.312875698776526	1038	0.002	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs	rRNA processing	snoRNA binding|single-stranded telomeric DNA binding|rRNA primary transcript binding	small-subunit processome|Mpp10 complex|90S preribosome
YDR243C	YDR243C	PRP28	het	Verified	0.422644257696146	0.336277415471238	no	331	0.336270888671095	1094	0.002	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING	NUCLEUS		RNA helicase in the DEAD-box family, involved in RNA isomerization at the 5' splice site	cis assembly of pre-catalytic spliceosome	ATP-dependent RNA helicase activity	spliceosomal complex|U5 snRNP
YDR301W	YDR301W	CFT1	het	Verified	0.420306532406635	0.33713076921098	no	332	0.336112486874403	1124	0.001	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS|MITOCHONDRION		RNA-binding subunit of the mRNA cleavage and polyadenylation factor; involved in poly(A) site recognition and required for both pre-mRNA cleavage and polyadenylation, 51% sequence similarity with mammalian AAUAA-binding subunit of CPSF	mRNA cleavage|termination of RNA polymerase II transcription|mRNA polyadenylation	RNA binding	mRNA cleavage factor complex|mitochondrion|mRNA cleavage and polyadenylation specificity factor complex
YPR019W	YPR019W	MCM4	het	Verified	0.41947557668985	0.337434300196306	no	333	0.31054476194578	1073	0.001	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Essential helicase component of heterohexameric MCM2-7 complexes which bind pre-replication complexes on DNA and melt DNA prior to replication; forms an Mcm4p-6p-7p subcomplex; shows nuclear accumulation in G1; homolog of S. pombe Cdc21p	S phase of mitotic cell cycle|DNA strand elongation involved in DNA replication|DNA unwinding involved in replication|double-strand break repair via break-induced replication|DNA replication initiation|pre-replicative complex assembly	four-way junction helicase activity|DNA helicase activity|DNA replication origin binding|single-stranded DNA-dependent ATPase activity|single-stranded DNA binding|ATP-dependent 3'-5' DNA helicase activity	replication fork protection complex|nuclear replication fork|DNA replication preinitiation complex|nucleus|pre-replicative complex|cytoplasm|MCM complex
YKL019W	YKL019W	RAM2	het	Verified	0.418590081177636	0.337757869904863	no	334	0.31048177817722	1012	0.003	FT	PROTEIN PRENYLATION			Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor	protein farnesylation|protein geranylgeranylation|peptide pheromone maturation	protein geranylgeranyltransferase activity|protein farnesyltransferase activity|CAAX-protein geranylgeranyltransferase activity	CAAX-protein geranylgeranyltransferase complex|protein farnesyltransferase complex
YJL002C	YJL002C	OST1	het	Verified	0.415655455350429	0.338831070535481	no	335	0.315189776335428	1039	0.000	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Alpha subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins	protein N-linked glycosylation via asparagine|protein N-linked glycosylation	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	oligosaccharyltransferase complex
YNR043W	YNR043W	MVD1	het	Verified	0.415289699646293	0.338964920347608	no	336	0.357139863582212	1191	0.001	FT	LIPID METABOLISM			Mevalonate pyrophosphate decarboxylase, essential enzyme involved in the biosynthesis of isoprenoids and sterols, including ergosterol; acts as a homodimer	sterol biosynthetic process	diphosphomevalonate decarboxylase activity	cytoplasm
YDR050C	YDR050C	TPI1	het	Verified	0.41475571941403	0.339160369128014	no	337	0.336039184702244	1151	0.002	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region; inhibition of Tpi1p activity by PEP (phosphoenolpyruvate) stimulates redox metabolism in respiring cells; E104D mutation in human TPI causes a rare autosomal disease	glycolysis	triose-phosphate isomerase activity	mitochondrion|plasma membrane|cytoplasm
YJL125C	YJL125C	GCD14	het	Verified	0.413185778382412	0.33973525344309	no	338	0.303427149140028	1021	0.002	FT	RNA PROCESSING	NUCLEUS		Subunit of tRNA (1-methyladenosine) methyltransferase, with Gcd10p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression	tRNA methylation	tRNA (adenine-N1-)-methyltransferase activity	tRNA (m1A) methyltransferase complex|nucleus
YDR016C	YDR016C	DAD1	het	Verified	0.41140519111238	0.340387724048912	no	339	0.33920235127593	1135	0.000	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME|CYTOSKELETON	KINETOCHORE	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis	mitotic spindle organization in nucleus|regulation of microtubule polymerization or depolymerization	microtubule binding|structural constituent of cytoskeleton	condensed nuclear chromosome kinetochore|DASH complex|spindle
YDR224C	YDR224C	HTB1	het	Verified	0.411180639747972	0.340470041654923	no	340	0.333006431238011	1142	0.003	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB2; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation	chromatin assembly or disassembly|negative regulation of transcription from RNA polymerase II promoter|postreplication repair	DNA binding	replication fork protection complex|nuclear nucleosome
YGR140W	YGR140W	CBF2	het	Verified	0.408018718706303	0.341629966180643	no	341	0.330958987420102	1099	0.004	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME|CYTOSKELETON	KINETOCHORE	Essential kinetochore protein; component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo; relative distribution to the spindle pole body decreases upon DNA replication stress	chromosome segregation|septin ring assembly|mitotic spindle elongation	DNA binding, bending|centromeric DNA binding	spindle midzone|condensed nuclear chromosome kinetochore|CBF3 complex|condensed nuclear chromosome, centromeric region|spindle
YDR041W	YDR041W	RSM10	het	Verified	0.40429180180307	0.342999076682377	no	342	0.332425654262661	1105	0.004	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YFL045C	YFL045C	SEC53	het	Verified	0.400448891825242	0.344412959780448	no	343	0.343502361771453	1143	0.002	FT	PROTEIN LOCALIZATION|CARBOHYDRATE METABOLISM			Phosphomannomutase, involved in synthesis of GDP-mannose and dolichol-phosphate-mannose; required for folding and glycosylation of secretory proteins in the ER lumen	protein targeting to ER	phosphomannomutase activity	cytosol
YIR010W	YIR010W	DSN1	het	Verified	0.397995419788712	0.345316780976814	no	344	0.345912791594991	1180	0.002	FT	CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME|CYTOSKELETON	KINETOCHORE	Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; important for chromosome segregation	chromosome segregation	molecular_function	nuclear MIS12/MIND type complex|kinetochore|spindle pole
YNL261W	YNL261W	ORC5	het	Verified	0.395523281235927	0.346228371705546	no	345	0.324137983212997	1105	0.002	FT	GENE SILENCING	NUCLEUS|CHROMOSOME		Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing	regulation of chromatin silencing at telomere|DNA replication initiation|pre-replicative complex assembly|chromatin silencing at silent mating-type cassette	DNA replication origin binding|ATP binding	DNA replication preinitiation complex|pre-replicative complex|nuclear origin of replication recognition complex
YNL251C	YNL251C	NRD1	het	Verified	0.3938650613569	0.34684033332643	no	346	0.3436700800407	1141	0.003	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3′ end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; interacts with the C-terminal domain of the RNA polymerase II large subunit (Rpo21p), preferentially at phosphorylated Ser5, to direct transcription termination of non-polyadenylated transcripts; H3K4 trimethylation of transcribed regions by Set1p enhances recruitment of Nrd1p to those sites	mRNA 3'-end processing|nuclear mRNA surveillance|termination of RNA polymerase II transcription, exosome-dependent|antisense RNA transcript catabolic process|tRNA 3'-end processing|snRNA 3'-end processing|snoRNA 3'-end processing|CUT catabolic process	RNA binding|transcription regulatory region RNA binding|protein domain specific binding	Nrd1 complex|nucleus
YLL034C	YLL034C	RIX7	het	Verified	0.391031611069274	0.347886935076876	no	347	0.328664207058139	1101	0.003	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS	NUCLEUS		Putative ATPase of the AAA family, required for export of pre-ribosomal large subunits from the nucleus; distributed between the nucleolus, nucleoplasm, and nuclear periphery depending on growth conditions	ribosomal large subunit biogenesis|ribosomal large subunit export from nucleus	ATPase activity	nucleolus|nucleus|preribosome, large subunit precursor
YHR019C	YHR019C	DED81	het	Verified	0.387600701612937	0.349155774813306	no	348	0.3376638168109	1143	0.004	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION			Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA	asparaginyl-tRNA aminoacylation	asparagine-tRNA ligase activity	cytosol
YPR165W	YPR165W	RHO1	het	Verified	0.383694645181643	0.350602390965954	no	349	0.404559567209635	1353	0.001	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM|CYTOSKELETON ORGANIZATION	MITOCHONDRION|GOLGI APPARATUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p)	regulation of fungal-type cell wall (1->3)-alpha-glucan biosynthetic process|regulation of fungal-type cell wall organization|positive regulation of endocytosis|budding cell bud growth|small GTPase mediated signal transduction|regulation of protein localization|positive regulation of protein kinase C signaling cascade|actin cytoskeleton organization|regulation of vacuole fusion, non-autophagic|actin cytoskeleton reorganization|regulation of exocyst localization|regulation of cell size	GTPase activity|signal transducer activity	incipient cellular bud site|mitochondrion|Golgi apparatus|peroxisome|cellular bud neck|cellular bud tip|mitochondrial outer membrane|1,3-beta-D-glucan synthase complex|plasma membrane|mating projection tip
YDR292C	YDR292C	SRP101	het	Verified	0.382979979321876	0.350867304319726	no	350	0.326528533967028	1100	0.004	FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Signal recognition particle (SRP) receptor alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with the beta subunit, Srp102p	SRP-dependent cotranslational protein targeting to membrane|protein targeting to ER	GTP binding|signal recognition particle binding	endoplasmic reticulum membrane|signal recognition particle receptor complex
YBR237W	YBR237W	PRP5	het	Verified	0.378825195636746	0.352408838015103	no	351	0.342815084778519	1163	0.001	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING	NUCLEUS		RNA helicase in the DEAD-box family, necessary for prespliceosome formation, bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA	mRNA branch site recognition	RNA-dependent ATPase activity	spliceosomal complex
YDR510W	YDR510W	SMT3	het	Verified	0.377378631082176	0.352946122442993	no	352	0.33963344669732	1135	0.000	FT		NUCLEUS|CHROMOSOME|CYTOSKELETON		Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics; phosphorylated at Ser2	protein sumoylation	protein tag	condensed nuclear chromosome|nucleus|septin ring
YMR218C	YMR218C	TRS130	het	Verified	0.377093008521547	0.353052243368776	no	353	0.34399345851625	1092	0.002	FT	VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM	GOLGI APPARATUS		One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in ER to Golgi membrane traffic; mutation activates transcription of OCH1; mutants are defective in cytoplasm-to-vacuole targeting (Cvt) pathway and starvation-induced autophagy	regulation of Rab GTPase activity|early endosome to Golgi transport|intra-Golgi vesicle-mediated transport	Rab guanyl-nucleotide exchange factor activity	TRAPP complex|trans-Golgi network|early endosome
YFL038C	YFL038C	YPT1	het	Verified	0.375309738720758	0.35371506209685	no	354	0.374127699812597	1244	0.003	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|SIGNALING|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS		Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)	Golgi vesicle budding|Golgi vesicle docking|early endosome to Golgi transport|macroautophagy|endocytic recycling|protein complex assembly|CVT pathway|retrograde vesicle-mediated transport, Golgi to ER|SNARE complex disassembly|ER to Golgi vesicle-mediated transport|COPII-coated vesicle budding	SNARE binding|GTPase activity	trans-Golgi network|mitochondrion|Golgi stack|endoplasmic reticulum membrane|Golgi membrane|pre-autophagosomal structure
YGL008C	YGL008C	PMA1	het	Verified	0.372258635482663	0.35485014656162	no	355	0.338617318780921	1125	0.008	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	MITOCHONDRION|PLASMA MEMBRANE		Plasma membrane H+-ATPase, pumps protons out of the cell; major regulator of cytoplasmic pH and plasma membrane potential; P2-type ATPase; Hsp30p plays a role in Pma1p regulation; interactions with Std1p appear to propagate [GAR+]	proton transport|regulation of pH|transmembrane transport	hydrogen-exporting ATPase activity, phosphorylative mechanism	mitochondrion|integral to membrane|membrane raft|plasma membrane
YJL076W	YJL076W	NET1	het	Verified	0.364163514165708	0.357867955293017	no	356	0.366824997814574	1205	0.002	FT	CELL CYCLE|CELL DIVISION|GENE SILENCING	NUCLEUS		Core subunit of the RENT complex; involved in nucleolar silencing and telophase exit; stimulates transcription by RNA polymerase I and regulates nucleolar structure; NET1 has a paralog, TOF2, that arose from the whole genome duplication	regulation of exit from mitosis|nucleolus organization|chromatin silencing at rDNA	rDNA binding	nucleolus|RENT complex
YGL245W	YGL245W	GUS1	het	Verified	0.362160452961322	0.358616065198819	no	357	0.365208769577428	1183	0.000	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION	MITOCHONDRION		Glutamyl-tRNA synthetase (GluRS); forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm; protein abundance increases in response to DNA replication stress	glutamyl-tRNA aminoacylation	glutamate-tRNA ligase activity	methionyl glutamyl tRNA synthetase complex|mitochondrion|cytoplasm
YDR526C_d	YDR526C	YDR526C	het	Dubious	0.361834091684684	0.358738007187454	no	358	0.397833365490851	1310	0.001	FF				Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKL173W	YKL173W	SNU114	het	Verified	0.360861961722516	0.359101320192587	no	359	0.352166523222893	1165	0.001	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEOTIDE METABOLISM	NUCLEUS		GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2	assembly of spliceosomal tri-snRNP|spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)|mRNA splicing, via spliceosome|generation of catalytic spliceosome for first transesterification step	GTP binding|GTPase activity|U5 snRNA binding	U4/U6 x U5 tri-snRNP complex|U5 snRNP
YNR038W	YNR038W	DBP6	het	Verified	0.360223351431655	0.359340056671106	no	360	0.364342109293391	1222	0.006	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Essential protein involved in ribosome biogenesis; putative ATP-dependent RNA helicase of the DEAD-box protein family	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	ATP-dependent RNA helicase activity	nucleolus|preribosome, large subunit precursor
YBL026W	YBL026W	LSM2	het	Verified	0.354541271655177	0.361466639867566	no	361	0.389682024199781	1282	0.001	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress	nuclear-transcribed mRNA catabolic process|mRNA splicing, via spliceosome	RNA binding	U6 snRNP|nucleolus|small nucleolar ribonucleoprotein complex|cytoplasmic mRNA processing body|U4/U6 x U5 tri-snRNP complex
YML105C	YML105C	SEC65	het	Verified	0.353187253957688	0.361974031403428	no	362	0.358669251878496	1199	0.002	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS			Subunit of the signal recognition particle (SRP), involved in protein targeting to the ER; interacts with Srp54p; homolog of mammalian SRP19	SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition|protein targeting to ER	7S RNA binding	signal recognition particle, endoplasmic reticulum targeting
YDL103C	YDL103C	QRI1	het	Verified	0.351039541888865	0.362779341789934	no	363	0.375049186651087	1256	0.005	FT	CARBOHYDRATE METABOLISM	NUCLEUS		UDP-N-acetylglucosamine pyrophosphorylase; catalyzes the formation of UDP-N-acetylglucosamine (UDP-GlcNAc), which is important in cell wall biosynthesis, protein N-glycosylation, and GPI anchor biosynthesis; protein abundance increases in response to DNA replication stress	UDP-N-acetylglucosamine biosynthetic process	UDP-N-acetylglucosamine diphosphorylase activity	nucleus|cytoplasm
YER008C	YER008C	SEC3	het	Verified	0.346098343222866	0.364634404248609	no	364	0.34933691137968	1156	0.003	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION	SITE OF POLARIZED GROWTH		Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in a Rho1p-dependent, actin-independent manner, targeting and anchoring the exocyst to the plasma membrane with Exo70p; direct GTP Rho1p effector; required for ER inheritance; relocalizes away from bud neck upon DNA replication stress	exocytosis|Golgi to plasma membrane transport|endoplasmic reticulum inheritance|exocyst localization|exocyst assembly|vesicle fusion|vesicle docking involved in exocytosis	Rho GTPase binding|phosphatidylinositol-4,5-bisphosphate binding	incipient cellular bud site|cellular bud neck|mating projection tip|exocyst|cellular bud tip
YBL076C	YBL076C	ILS1	het	Verified	0.343089548350275	0.365765546839995	no	365	0.364075423573566	1208	0.003	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION			Cytoplasmic isoleucine-tRNA synthetase, target of the G1-specific inhibitor reveromycin A	cytoplasmic translation|isoleucyl-tRNA aminoacylation	isoleucine-tRNA ligase activity	cytosol
YKL021C	YKL021C	MAK11	het	Verified	0.339797048277463	0.367004685465689	no	366	0.368825976700555	1244	0.003	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	ENDOMEMBRANE SYSTEM|NUCLEUS		Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats	ribosomal large subunit assembly|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal large subunit biogenesis|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	membrane
YNL137C	YNL137C	NAM9	het	Verified	0.337012876591569	0.368053596620661	no	367	0.378877727572977	1269	0.002	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal component of the small subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YLL004W	YLL004W	ORC3	het	Verified	0.33550396821918	0.368622475903836	no	368	0.356753021001281	1222	0.000	FT	GENE SILENCING	NUCLEUS|CHROMOSOME		Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing	pre-replicative complex assembly|DNA replication initiation|chromatin silencing at silent mating-type cassette	chromatin binding|DNA replication origin binding	DNA replication preinitiation complex|pre-replicative complex|nuclear origin of replication recognition complex
YMR290C	YMR290C	HAS1	het	Verified	0.335219737708669	0.36872966700603	no	369	0.364626996702135	1209	0.005	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	ENDOMEMBRANE SYSTEM|NUCLEUS		ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles	rRNA processing	RNA binding|RNA-dependent ATPase activity|ATP-dependent RNA helicase activity	nuclear envelope|nucleolus|preribosome, large subunit precursor|90S preribosome
YLR022C	YLR022C	SDO1	het	Verified	0.330588889139351	0.370477519973468	no	370	0.372268312970384	1219	0.001	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS	NUCLEUS		Essential protein involved in ribosome maturation; with Ria1p, promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; ortholog of the human protein (SBDS) responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome; highly conserved across archaea and eukaryotes	mature ribosome assembly	molecular_function	nucleus|preribosome, large subunit precursor|polysome|cytoplasm
YJL015C_d	YJL015C	YJL015C	het	Dubious	0.329612486158088	0.370846393408696	no	371	0.366791970454557	1237	0.002					Dubious open reading frame unlikely to encode a functional protein; expression if heat-inducible; located in promoter region of essential CCT3 gene encoding a subunit of the cytosolic chaperonin Cct ring complex, overlaps ORF YJL016W	Unknown	Unknown	Unknown
YLL050C	YLL050C	COF1	het	Verified	0.327241793935788	0.371742506240253	no	372	0.362150053159806	1201	0.000	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	NUCLEUS|CYTOSKELETON		Cofilin, involved in pH-dependent actin filament depolarization; binds both actin monomers and filaments and severs filaments; involved in the selective sorting, export of the secretory cargo from the late golgi; genetically interacts with pmr1; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes	actin filament depolymerization|actin filament severing	actin filament binding	plasma membrane|actin cortical patch
YNL172W	YNL172W	APC1	het	Verified	0.327220489800406	0.371750562283792	no	373	0.35604359404751	1206	0.003	FT	CELL CYCLE|CELL DIVISION|PROTEOLYSIS	NUCLEUS|CYTOSKELETON	UBIQUITIN LIGASE COMPLEX	Largest subunit of the Anaphase-Promoting Complex/Cyclosome; APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; localizes to nuclear foci that become diffuse upon DNA replication stress	mitotic metaphase/anaphase transition|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|exit from mitosis|cyclin catabolic process|protein ubiquitination	ubiquitin-protein ligase activity	anaphase-promoting complex
YMR001C	YMR001C	CDC5	het	Verified	0.324414013292685	0.37281230594223	no	374	0.353088086405597	1204	0.000	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|CHROMOSOME SEGREGATION	NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON		Polo-like kinase with multiple functions in mitosis and cytokinesis through substrate phosphorylation, also functions in adaptation to DNA damage during meiosis; has similarity to Xenopus Plx1 and S. pombe Plo1p; possible Cdc28p substrate	synaptonemal complex disassembly|spindle assembly involved in meiosis|protein phosphorylation|resolution of meiotic recombination intermediates|positive regulation of spindle pole body separation	protein kinase activity	nucleus|cellular bud neck|spindle pole
YPL082C	YPL082C	MOT1	het	Verified	0.324066761073896	0.37294374547502	no	375	0.361383936775999	1185	0.002	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS|MITOCHONDRION|CHROMOSOME		Essential protein involved in regulation of transcription; removes Spt15p (TBP) from DNA via its C-terminal ATPase activity, forms a complex with TBP that binds TATA DNA with high affinity but with altered specificity; the Mot1p-Spt15p-DNA ternary complex contains unbent DNA	regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription of nuclear large rRNA transcript from RNA polymerase I promoter|regulation of transcription from RNA polymerase II promoter|rRNA processing	TBP-class protein binding|ATPase activity	nuclear chromosome|mitochondrion
YLR339C_d	YLR339C	YLR339C	het	Dubious	0.321918999035149	0.373757029791473	no	376	0.383053208369929	1263	0.001					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPP0	Unknown	Unknown	Unknown
YJR022W	YJR022W	LSM8	het	Verified	0.320854261252421	0.374160418476394	no	377	0.339408578072509	1128	0.003	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNA	mRNA splicing, via spliceosome	RNA binding	U6 snRNP|nucleolus|nucleus|U4/U6 x U5 tri-snRNP complex
YDR082W	YDR082W	STN1	het	Verified	0.318031220472264	0.375230627449227	no	378	0.364126685163531	1230	0.006	FT		NUCLEUS|CHROMOSOME		Telomere end-binding and capping protein, plays a key role with Pol12p in linking telomerase action with completion of lagging strand synthesis, and in a regulatory step required for telomere capping	telomere capping|negative regulation of telomere maintenance via telomerase	single-stranded telomeric DNA binding	nuclear telomere cap complex
YDR246W	YDR246W	TRS23	het	Verified	0.311534222965774	0.377697265102877	no	379	0.357006182575328	1204	0.001	FT	VESICLE-MEDIATED TRANSPORT	ENDOPLASMIC RETICULUM|GOLGI APPARATUS		One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic; human homolog is TRAPPC4	chromosome organization|ER to Golgi vesicle-mediated transport	Rab guanyl-nucleotide exchange factor activity	TRAPP complex
YER009W	YER009W	NTF2	het	Verified	0.310725430210485	0.378004681529814	no	380	0.370423390409539	1227	0.004	FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS		Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport	nucleocytoplasmic transport|protein import into nucleus	Ran GTPase binding	nuclear envelope|integral to membrane
YDR531W	YDR531W	CAB1	het	Verified	0.306550220770438	0.379592874190475	no	381	0.384563676313978	1283	0.001	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	NUCLEUS		Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway for synthesis of coenzyme A (CoA); transcriptionally regulated by Upc2p via a sterol response element	coenzyme A biosynthetic process	pantothenate kinase activity	nucleus|cytoplasm
YHR118C	YHR118C	ORC6	het	Verified	0.305929845226083	0.379829030752793	no	382	0.357997109728208	1176	0.001	FT	GENE SILENCING	NUCLEUS|CHROMOSOME		Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; phosphorylated by Cdc28p	DNA replication initiation|pre-replicative complex assembly|chromatin silencing at silent mating-type cassette	DNA replication origin binding	pre-replicative complex|DNA replication preinitiation complex|nuclear origin of replication recognition complex
YOR143C	YOR143C	THI80	het	Verified	0.304632747983276	0.380322937745151	no	383	0.357529004628514	1188	0.003	FT	COFACTOR METABOLISM			Thiamine pyrophosphokinase, phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate)	thiamine diphosphate biosynthetic process	thiamine diphosphokinase activity	cytoplasm
YDR327W_d	YDR327W	YDR327W	het	Dubious	0.301145089908688	0.381651929572217	no	384	0.354931578289612	1170	0.001					Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SKP1	Unknown	Unknown	Unknown
YDL212W	YDL212W	SHR3	het	Verified	0.29976299390638	0.382178972260065	no	385	0.391163195291144	1306	0.001	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH		Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface	protein folding|ER to Golgi vesicle-mediated transport	unfolded protein binding	integral to endoplasmic reticulum membrane|integral to membrane|mating projection tip
YPL255W	YPL255W	BBP1	het	Verified	0.299001340254059	0.382469511467243	no	386	0.422532853029162	1376	0.002	FT	CELL CYCLE|CYTOSKELETON ORGANIZATION	NUCLEUS|CYTOSKELETON		Protein required for the spindle pole body (SPB) duplication, localized at the central plaque periphery; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p	microtubule nucleation|spindle pole body duplication associated with nuclear envelope	structural constituent of cytoskeleton	spindle pole body
YLR103C	YLR103C	CDC45	het	Verified	0.29657204278552	0.383396628839598	no	387	0.375555827839611	1254	0.001	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS|CHROMOSOME		DNA replication initiation factor; recruited to MCM pre-RC complexes at replication origins; promotes release of MCM from Mcm10p, recruits elongation machinery; mutants in human homolog may cause velocardiofacial and DiGeorge syndromes	S phase of mitotic cell cycle|regulation of chromatin silencing at telomere|DNA replication initiation|pre-replicative complex assembly|double-strand break repair via break-induced replication	DNA replication origin binding|chromatin binding	replication fork protection complex|nucleus|DNA replication preinitiation complex|nuclear replication fork|pre-replicative complex
YER136W	YER136W	GDI1	het	Verified	0.296032713240289	0.383602549446554	no	388	0.35212293776671	1180	0.000	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT			GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins	vesicle-mediated transport	Rab GDP-dissociation inhibitor activity	cellular_component
YPR041W	YPR041W	TIF5	het	Verified	0.295793391702806	0.383693934980151	no	389	0.378838630048521	1248	0.000	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Translation initiation factor eIF5; functions both as a GTPase-activating protein to mediate hydrolysis of ribosome-bound GTP and as a GDP dissociation inhibitor to prevent recycling of eIF2	mature ribosome assembly|negative regulation of translational initiation|regulation of translational initiation	translation initiation factor binding|GDP-dissociation inhibitor activity|GTPase activator activity|translation initiation factor activity	cytosolic small ribosomal subunit|multi-eIF complex
YFR031C	YFR031C	SMC2	het	Verified	0.29540277350288	0.383843107421302	no	390	0.37727606495245	1254	0.009	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS|MITOCHONDRION|CHROMOSOME		Subunit of the condensin complex; essential SMC chromosomal ATPase family member that forms a complex with Smc4p to form the active ATPase; Smc2p/Smc4p complex binds DNA; required for clustering of tRNA genes at the nucleolus	mitotic chromosome condensation|mitotic sister chromatid segregation|tRNA gene clustering	double-stranded DNA binding|ATPase activity|AT DNA binding|DNA secondary structure binding	mitochondrion|nuclear condensin complex
YDR168W	YDR168W	CDC37	het	Verified	0.286397616577563	0.387286799990861	no	391	0.393647044670212	1299	0.002	FT	CELL CYCLE|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION			Essential Hsp90p co-chaperone; necessary for passage through the START phase of the cell cycle; stabilizes protein kinase nascent chains and participates along with Hsp90p in their folding	regulation of stress-activated MAPK cascade|regulation of cell cycle|MAPK cascade involved in osmosensory signaling pathway|protein stabilization|spindle pole body duplication associated with nuclear envelope	unfolded protein binding	cytoplasm
YGR113W	YGR113W	DAM1	het	Verified	0.284501572187927	0.388013014681715	no	392	0.347275009104264	1153	0.001	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME|CYTOSKELETON	KINETOCHORE	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; Ipl1p target for regulating kinetochore-MT attachments	mitotic spindle organization in nucleus|regulation of microtubule polymerization or depolymerization	microtubule binding|structural constituent of cytoskeleton	spindle midzone|DASH complex|condensed nuclear chromosome kinetochore|kinetochore microtubule|spindle
YNL110C	YNL110C	NOP15	het	Verified	0.283609401285671	0.38835486582379	no	393	0.415862689647071	1373	0.002	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|CELL DIVISION|CYTOSKELETON ORGANIZATION	NUCLEUS		Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm	cytokinesis, actomyosin contractile ring assembly|ribosomal large subunit biogenesis	molecular_function	nucleolus|nucleus|preribosome, large subunit precursor
YNL244C	YNL244C	SUI1	het	Verified	0.281631553419986	0.389113021502722	no	394	0.386730765087204	1290	0.002	FT	TRANSLATION			Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase	translational initiation	translation initiation factor binding|translation initiation factor activity	multi-eIF complex
YBR080C	YBR080C	SEC18	het	Verified	0.279950809377952	0.389757622406279	no	395	0.372847977806358	1240	0.000	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RESPONSE TO NUTRIENT LEVELS	SITE OF POLARIZED GROWTH		ATPase required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, autophagy, and protein secretion; releases Sec17p from SNAP complexes; has similarity to mammalian NSF	Golgi vesicle docking|SNARE complex disassembly|Golgi to plasma membrane protein transport|vesicle fusion with Golgi apparatus|vacuole fusion, non-autophagic|inter-Golgi cisterna vesicle-mediated transport|autophagic vacuole assembly	ATPase activity	mating projection tip|cytoplasm
YBR109C	YBR109C	CMD1	het	Verified	0.279627358212792	0.389881707633008	no	396	0.401409929796407	1328	0.006	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|LIPID METABOLISM|MEMBRANE ORGANIZATION|CELL DIVISION|CYTOSKELETON ORGANIZATION	NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON		Calmodulin; Ca++ binding protein that regulates Ca++ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca++ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin	karyogamy involved in conjugation with cellular fusion|phosphatidylinositol biosynthetic process|NLS-bearing substrate import into nucleus|microautophagy|cell budding|vacuole fusion, non-autophagic|receptor-mediated endocytosis|cytoskeleton organization|spindle pole body organization|transcription factor import into nucleus	calcium-dependent protein binding|protein binding|calcium ion binding	incipient cellular bud site|central plaque of spindle pole body|mating projection tip|cellular bud neck|cellular bud tip
YPR094W	YPR094W	RDS3	het	Verified	0.273657349935306	0.392173978367286	no	397	0.4046264703722	1324	0.001	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING	NUCLEUS		Component of the SF3b subcomplex of the U2 snRNP, zinc cluster protein involved in pre-mRNA splicing and cycloheximide resistance	spliceosomal complex assembly|response to xenobiotic stimulus|mRNA splicing, via spliceosome	molecular_function	U2 snRNP
YBL020W	YBL020W	RFT1	het	Verified	0.272419754178693	0.392649642619475	no	398	0.394643529336465	1299	0.000	FT	MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Essential integral membrane protein that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane but is not the flippase; mutation is suppressed by expression of human p53 protein	glycolipid translocation	molecular_function|glycolipid-translocating activity	integral to membrane|endoplasmic reticulum membrane
YNL232W	YNL232W	CSL4	het	Verified	0.27205599906936	0.392789480757338	no	399	0.408606332305873	1339	0.001	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain an S1 RNA binding domain; has similarity to human hCsl4p (EXOSC1)	nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear polyadenylation-dependent mRNA catabolic process|nonfunctional rRNA decay|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|polyadenylation-dependent snoRNA 3'-end processing|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|nuclear-transcribed mRNA catabolic process, non-stop decay|ncRNA 3'-end processing	molecular_function	nucleus|nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)|cytoplasm
YPL007C	YPL007C	TFC8	het	Verified	0.270713482647399	0.393305703124686	no	400	0.376992449926965	1266	0.000	FT		NUCLEUS		One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; linker between TauB and TauA domains; human homolog is TFIIIC-90	transcription from a RNA polymerase III hybrid type promoter|transcription from RNA polymerase III type 2 promoter|5S class rRNA transcription from RNA polymerase III type 1 promoter|transcription from RNA polymerase III promoter	RNA polymerase III type 1 promoter sequence-specific DNA binding|RNA polymerase III type 2 promoter sequence-specific DNA binding|RNA polymerase III type 2 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity|RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity|DNA binding, bending	transcription factor TFIIIC complex
YDL164C	YDL164C	CDC9	het	Verified	0.270614204704073	0.393343884789934	no	401	0.387097101783995	1298	0.002	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION	NUCLEUS|MITOCHONDRION|CHROMOSOME		DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication; also acts in nucleotide excision repair, base excision repair, and recombination	lagging strand elongation|base-excision repair|mitotic cell cycle|DNA ligation|DNA recombination|nucleotide-excision repair	DNA ligase (ATP) activity	mitochondrion|nucleus|replication fork
YBL034C	YBL034C	STU1	het	Verified	0.268259994865164	0.394249598717126	no	402	0.376376582905758	1231	0.000	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION	NUCLEUS|CHROMOSOME|CYTOSKELETON		Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles	microtubule nucleation	structural constituent of cytoskeleton	spindle pole body
YHR024C	YHR024C	MAS2	het	Verified	0.267954489514285	0.394367175078923	no	403	0.412580911964014	1335	0.002	FT	PROTEIN LOCALIZATION|PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Larger subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins	protein processing involved in protein targeting to mitochondrion	metalloendopeptidase activity	mitochondrion|mitochondrial processing peptidase complex
YIR015W	YIR015W	RPR2	het	Verified	0.265623415462955	0.395264625152507	no	404	0.399882011654641	1313	0.003	FT	RNA PROCESSING	NUCLEUS		Subunit of nuclear RNase P; nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; not shared between RNase MRP and RNase P, in contrast to all other RNase P protein subunits; protein abundance increases in response to DNA replication stress	tRNA processing|intronic box C/D snoRNA processing	ribonuclease P activity	nucleolar ribonuclease P complex
YGL074C_d	YGL074C	YGL074C	het	Dubious	0.262523322819193	0.396459003356126	no	405	0.407481242620992	1356	0.001					Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential HSF1 gene encoding heat shock transcription factor	Unknown	Unknown	Unknown
YNL310C	YNL310C	ZIM17	het	Verified	0.261186922209435	0.39697418137654	no	406	0.376952121545868	1241	0.002	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Heat shock protein with a zinc finger motif; essential for protein import into mitochondria; may act with Pam18p to facilitate recognition and folding of imported proteins by Ssc1p (mtHSP70) in the mitochondrial matrix	protein folding|protein stabilization|protein import into mitochondrial matrix|response to unfolded protein|mitochondrion organization	chaperone binding	mitochondrion|mitochondrial matrix
YJL156C	YJL156C	SSY5	het	Verified	0.259015792405255	0.39781152780993	no	407	0.390071515625964	1264	0.003	FT	PROTEOLYSIS	PLASMA MEMBRANE		Serine protease of SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p); contains an inhibitory domain that dissociates in response to extracellular amino acids, freeing a catalytic domain to activate transcription factor Stp1p	protein processing|response to amino acid stimulus	serine-type endopeptidase activity	extrinsic to plasma membrane
YOR149C	YOR149C	SMP3	het	Verified	0.25651474935933	0.398776696503699	no	408	0.375527004733171	1267	0.000	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Alpha 1,2-mannosyltransferase involved in glycosyl phosphatidyl inositol (GPI) biosynthesis; required for addition of the fourth, side branching mannose to the GPI core structure	GPI anchor biosynthetic process|plasmid maintenance	dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity	integral to membrane|endoplasmic reticulum
YMR134W	YMR134W	ERG29	het	Verified	0.256496110972657	0.398783891509903	no	409	0.401904299377335	1323	0.001	FT	LIPID METABOLISM|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Protein of unknown function that may be involved in iron metabolism; mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p; shows localization to the ER; highly conserved in ascomycetes	cellular iron ion homeostasis|mitochondrion organization	molecular_function	nuclear envelope|endoplasmic reticulum|cytoplasm
YPL043W	YPL043W	NOP4	het	Verified	0.255752156288979	0.399071109588592	no	410	0.393488829662754	1305	0.001	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs)	rRNA processing	RNA binding	nucleolus
YCL004W	YCL004W	PGS1	het	Verified	0.255229369033831	0.399272974414482	no	411	0.403386877397875	1350	0.003	FT	LIPID METABOLISM	MITOCHONDRION		Phosphatidylglycerolphosphate synthase, catalyzes the synthesis of phosphatidylglycerolphosphate from CDP-diacylglycerol and sn-glycerol 3-phosphate in the first committed and rate-limiting step of cardiolipin biosynthesis	cardiolipin biosynthetic process	CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity	mitochondrion
YDL205C	YDL205C	HEM3	het	Verified	0.252150488210972	0.400462373214084	no	412	0.392427585017086	1283	0.001	FT	COFACTOR METABOLISM	NUCLEUS		Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme	heme biosynthetic process	hydroxymethylbilane synthase activity	nucleus|cytoplasm
YBR198C	YBR198C	TAF5	het	Verified	0.251530039117316	0.400702170338998	no	413	0.418590454804273	1369	0.004	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS	RNA POL II, HOLOENZYME|HISTONE ACETYLTRANSFERASE	Subunit (90 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification	histone acetylation|RNA polymerase II transcriptional preinitiation complex assembly|chromatin modification|transcription from RNA polymerase II promoter	ubiquitin binding|chromatin binding|protein complex scaffold|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly	SLIK (SAGA-like) complex|SAGA complex|transcription factor TFIID complex
YLR167W	YLR167W	RPS31	het	Verified	0.247528651386991	0.402249560318896	no	414	0.418364998997905	1377	0.003	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|RESPONSE TO DNA DAMAGE|TRANSLATION	NUCLEUS	RIBOSOME	Fusion protein cleaved to yield ribosomal protein S31 and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B; homologous to mammalian ribosomal protein S27A, no bacterial homolog	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S)|ribosomal small subunit assembly|ribosome biogenesis	structural constituent of ribosome|protein tag	cytosolic small ribosomal subunit|cytoplasm
YJL032W_d	YJL032W	YJL032W	het	Dubious	0.244291504143164	0.403502531449025	no	415	0.411681819421725	1355	0.003					Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential BET4 gene encoding the alpha subunit of Type II geranylgeranyltransferase	Unknown	Unknown	Unknown
YBR140C	YBR140C	IRA1	het	Verified	0.241006547634072	0.404775020902498	no	416	0.434392559615914	1424	0.001	FF|FT	SIGNALING|NUCLEOTIDE METABOLISM	MITOCHONDRION|PLASMA MEMBRANE		GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase; IRA1 has a paralog, IRA2, that arose from the whole genome duplication	negative regulation of cAMP biosynthetic process|negative regulation of Ras protein signal transduction|regulation of adenylate cyclase activity|positive regulation of Ras GTPase activity	Ras GTPase activator activity	mitochondrion|integral to membrane|membrane
YCL031C	YCL031C	RRP7	het	Verified	0.239520302730009	0.405351077630872	no	417	0.416102526983115	1368	0.001	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Essential protein involved in rRNA processing and ribosome biogenesis; protein abundance increases in response to DNA replication stress	ribosomal small subunit assembly|rRNA processing	molecular_function	nucleolus|nucleus|UTP-C complex|CURI complex
YNR017W	YNR017W	TIM23	het	Verified	0.238745145950956	0.405651603704507	no	418	0.406284503696985	1335	0.001	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein import into mitochondrial matrix and inner membrane; with Tim17p, contributes to architecture and function of the import channel	protein import into mitochondrial matrix	mitochondrion targeting sequence binding|protein channel activity	mitochondrion|integral to membrane|mitochondrial inner membrane presequence translocase complex
YPR025C	YPR025C	CCL1	het	Verified	0.23785667879542	0.40599612829015	no	419	0.409774004923102	1352	0.001	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|PROTEIN PHOSPHORYLATION	NUCLEUS|MITOCHONDRION	RNA POL II, HOLOENZYME	Cyclin associated with protein kinase Kin28p, which is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters	phosphorylation of RNA polymerase II C-terminal domain|transcription from RNA polymerase II promoter	core RNA polymerase binding transcription factor activity|cyclin-dependent protein kinase regulator activity	mitochondrion|holo TFIIH complex|TFIIK complex
YHR088W	YHR088W	RPF1	het	Verified	0.237157601587001	0.406267263552231	no	420	0.408756980238065	1349	0.001	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Nucleolar protein involved in the assembly and export of the large ribosomal subunit; constituent of 66S pre-ribosomal particles; contains a sigma(70)-like motif, which is thought to bind RNA	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal large subunit assembly|ribosomal large subunit export from nucleus|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	rRNA primary transcript binding	nucleolus|preribosome, large subunit precursor
YBR253W	YBR253W	SRB6	het	Verified	0.236313410391618	0.406594740804067	no	421	0.404786176820177	1370	0.001	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RNA POL II, HOLOENZYME	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation	positive regulation of transcription from RNA polymerase II promoter	molecular_function	core mediator complex
YHR188C	YHR188C	GPI16	het	Verified	0.234962778369644	0.407118811539004	no	422	0.399125988004046	1322	0.000	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Tp homolog	attachment of GPI anchor to protein	GPI-anchor transamidase activity	GPI-anchor transamidase complex
YLR359W	YLR359W	ADE13	het	Verified	0.234499035748879	0.407298790841953	no	423	0.406430035007269	1359	0.002	FT	NUCLEOTIDE METABOLISM			Adenylosuccinate lyase, catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human ortholog ADSL cause adenylosuccinase deficiency	purine nucleotide biosynthetic process|'de novo' IMP biosynthetic process	N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity	cellular_component
YMR013C	YMR013C	SEC59	het	Verified	0.232096508302603	0.408231528405578	no	424	0.401076214501264	1305	0.001	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Dolichol kinase, catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis; required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylation	protein glycosylation	dolichol kinase activity	integral to membrane|endoplasmic reticulum membrane
YML069W	YML069W	POB3	het	Verified	0.231383618954413	0.408508395042391	no	425	0.402022203463868	1333	0.000	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Subunit of the heterodimeric FACT complex (Spt16p-Pob3p); FACT associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; protein abundance increases in response to DNA replication stress	DNA replication-independent nucleosome organization|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|regulation of transcription by chromatin organization|DNA-dependent DNA replication	chromatin binding|nucleosome binding|histone binding	nuclear chromatin|FACT complex|replication fork protection complex|alpha DNA polymerase:primase complex
YKL042W	YKL042W	SPC42	het	Verified	0.23114262029098	0.408602002638651	no	426	0.419020325528646	1398	0.000	FT	CELL CYCLE|CYTOSKELETON ORGANIZATION	NUCLEUS|CYTOSKELETON		Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane	microtubule nucleation|spindle pole body duplication associated with nuclear envelope	structural constituent of cytoskeleton	central plaque of spindle pole body|intermediate layer of spindle pole body
YER018C	YER018C	SPC25	het	Verified	0.231088067391998	0.408623192549605	no	427	0.386885086363197	1282	0.001	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME	KINETOCHORE	Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering	microtubule nucleation|chromosome segregation	structural constituent of cytoskeleton	Ndc80 complex|condensed nuclear chromosome kinetochore|condensed nuclear chromosome, centromeric region
YOR174W	YOR174W	MED4	het	Verified	0.229623058162796	0.409192343881941	no	428	0.424430837930515	1405	0.004	FF|FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RNA POL II, HOLOENZYME	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation	transcription from RNA polymerase II promoter	molecular_function	core mediator complex
YGR074W	YGR074W	SMD1	het	Verified	0.226068118522801	0.410574220226614	no	429	0.395438886527352	1310	0.000	FT	RNA PROCESSING	NUCLEUS		Core Sm protein Sm D1; part of heteroheptameric complex (with Smb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D1; protein abundance increases in response to DNA replication stress	mRNA splicing, via spliceosome	mRNA binding	commitment complex|U1 snRNP|U4/U6 x U5 tri-snRNP complex|U2-type prespliceosome|U5 snRNP
YBR153W	YBR153W	RIB7	het	Verified	0.225831033443474	0.410666419654034	no	430	0.401702582770968	1325	0.002	FT	OXIDATION-REDUCTION PROCESS			Diaminohydroxyphoshoribosylaminopyrimidine deaminase; catalyzes the second step of the riboflavin biosynthesis pathway	riboflavin biosynthetic process	5-amino-6-(5-phosphoribosylamino)uracil reductase activity	cellular_component
YDL148C	YDL148C	NOP14	het	Verified	0.224227124966579	0.411290289052602	no	431	0.422578718180189	1401	0.001	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS|MITOCHONDRION		Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal small subunit biogenesis|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA processing	snoRNA binding	small-subunit processome|mitochondrion|nucleolus|90S preribosome|Noc4p-Nop14p complex
YFL037W	YFL037W	TUB2	het	Verified	0.223500846454065	0.41157286220714	no	432	0.405171730031518	1344	0.001	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|NUCLEOTIDE METABOLISM|CHROMOSOME SEGREGATION	NUCLEUS|CYTOSKELETON		Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria	nuclear migration along microtubule|nuclear migration involved in conjugation with cellular fusion|homologous chromosome segregation|mitotic sister chromatid segregation	structural constituent of cytoskeleton	tubulin complex|kinetochore microtubule|cytoplasmic microtubule|nuclear microtubule|spindle pole body|polar microtubule
YOL149W	YOL149W	DCP1	het	Verified	0.222093111467792	0.412120700107228	no	433	0.413458947156529	1378	0.000	FT	RNA PROCESSING			Subunit of the Dcp1p-Dcp2p decapping enzyme complex; decapping complex removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p; forms cytoplasmic foci upon DNA replication stress	deadenylation-dependent decapping of nuclear-transcribed mRNA	mRNA binding|enzyme activator activity|m7G(5')pppN diphosphatase activity	cytoplasmic mRNA processing body
YLR140W_d	YLR140W	YLR140W	het	Dubious	0.221692687596664	0.412276561467341	no	434	0.416755558168482	1393	0.002					Dubious open reading frame unlikely to encode a functional protein; overlaps essential RRN5 gene which encodes a member of the UAF transcription factor involved in transcription of rDNA by RNA polymerase I	Unknown	Unknown	Unknown
YMR200W	YMR200W	ROT1	het	Verified	0.220092929706735	0.41289939054464	no	435	0.392938301463897	1317	0.001	FT	CELL CYCLE|SIGNALING|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM|CYTOSKELETON ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Molecular chaperone involved in protein folding in the ER; mutation causes defects in cell wall synthesis and in lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations; involved in N-linked glycosylation and O-mannosylation	budding cell apical bud growth|cell cycle cytokinesis|establishment or maintenance of actin cytoskeleton polarity|protein O-linked mannosylation|endoplasmic reticulum unfolded protein response|protein folding|fungal-type cell wall biogenesis|'de novo' protein folding|protein N-linked glycosylation	unfolded protein binding	endoplasmic reticulum|endoplasmic reticulum membrane
YER012W	YER012W	PRE1	het	Verified	0.219342615970146	0.413191583657514	no	436	0.428906497225272	1432	0.000	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle	proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process	endopeptidase activator activity	proteasome storage granule|nucleus|endoplasmic reticulum membrane|proteasome core complex, beta-subunit complex
YGL247W	YGL247W	BRR6	het	Verified	0.219333601492218	0.413195094439523	no	437	0.420499326904258	1386	0.001	FT	PROTEIN LOCALIZATION|LIPID METABOLISM|MEMBRANE ORGANIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS		Essential nuclear envelope integral membrane protein required for nuclear envelope morphology, nuclear pore complex localization, nuclear export; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism	mRNA export from nucleus|protein export from nucleus|cellular lipid metabolic process	molecular_function	nuclear envelope
YLL037W_d	YLL037W	YLL037W	het	Dubious	0.218176891127445	0.413645644795025	no	438	0.4051003298425	1367	0.000					Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential PRP19 gene encoding an RNA splicing factor	Unknown	Unknown	Unknown
YGL102C_d	YGL102C	YGL102C	het	Dubious	0.21777991527105	0.41380029713536	no	439	0.429674869905715	1409	0.002					Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential RPL28 gene encoding a large subunit ribosomal protein	Unknown	Unknown	Unknown
YGR075C	YGR075C	PRP38	het	Verified	0.215477780460432	0.414697416906638	no	440	0.419943184911491	1378	0.000	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING	NUCLEUS		Unique component of the U4/U6.U5 tri-snRNP particle, required for conformational changes which result in the catalytic activation of the spliceosome; dispensible for spliceosome assembly	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)	molecular_function	U4/U6 x U5 tri-snRNP complex
YNL161W	YNL161W	CBK1	het	Verified	0.215200741063841	0.414805406588815	no	441	0.402420753292708	1331	0.000	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	NUCLEUS|SITE OF POLARIZED GROWTH		Serine/threonine protein kinase of the the RAM signaling network; Ndr/LATS family member; binds regulatory subunit Mob2p; involved in regulation of cellular morphogenesis, polarized growth, and septum destruction; phosphorylation by Cbk1p regulates localization and activity of Ace2p transcription factor and Ssd1p translational repressor; Cbk1p activity is regulated by both phosphorylation and specific localization; relocalizes to cytoplasm upon DNA replication stress	regulation of fungal-type cell wall organization|establishment or maintenance of cell polarity|protein phosphorylation|establishment or maintenance of actin cytoskeleton polarity|budding cell apical bud growth|Unknown	protein serine/threonine kinase activity	incipient cellular bud site|cellular bud|cellular bud neck|cellular bud tip|cytoplasm|cell cortex|nucleus|mating projection tip
YIL019W	YIL019W	FAF1	het	Verified	0.215127057818006	0.414834129329256	no	442	0.398319170490092	1307	0.003	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Protein required for pre-rRNA processing and 40S ribosomal subunit assembly	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	nucleolus|nucleus|cytoplasm
YPL243W	YPL243W	SRP68	het	Verified	0.211904190693746	0.416090890569533	no	443	0.412295939593118	1359	0.001	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS	NUCLEUS		Core component of the signal recognition particle (SRP) complex; SRP complex functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress	SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition|protein targeting to ER	signal sequence binding	signal recognition particle, endoplasmic reticulum targeting
YML043C	YML043C	RRN11	het	Verified	0.210998029605105	0.416444404446467	no	444	0.382445523697027	1254	0.001	FT		NUCLEUS		Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p	transcription initiation from RNA polymerase I promoter|transcription of nuclear large rRNA transcript from RNA polymerase I promoter	TBP-class protein binding|RNA polymerase I CORE element sequence-specific DNA binding|RNA polymerase I CORE element sequence-specific DNA binding transcription factor recruiting transcription factor activity	RNA polymerase I core factor complex
YGL113W	YGL113W	SLD3	het	Verified	0.210096379425472	0.416796225610278	no	445	0.412065840920206	1375	0.003	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Protein involved in the initiation of DNA replication; required for proper assembly of replication proteins at the origins of replication; interacts with Cdc45p; localizes to nuclear foci that become diffuse upon DNA replication stress	DNA unwinding involved in replication|double-strand break repair via break-induced replication|DNA replication initiation	chromatin binding	nuclear chromatin|DNA replication preinitiation complex
YDR190C	YDR190C	RVB1	het	Verified	0.207095814988141	0.417967515204199	no	446	0.424884125142537	1430	0.002	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		ATP-dependent DNA helicase, also known as pontin; member of the AAA+ and RuvB-like protein families; similar to Rvb2p; conserved component of multiple complexes including the INO80 complex, the Swr1 complex, and the R2TP complex (Rvb1-Rvb2-Tah1-Pih1); involved in multiple processes such as chromatin remodeling, box C/D snoRNP assembly, and RNA polymerase II assembly	regulation of transcription from RNA polymerase II promoter|box C/D snoRNP assembly|chromatin remodeling|histone exchange	ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 3'-5' DNA helicase activity	ASTRA complex|R2TP complex|Swr1 complex|nucleus|Ino80 complex
YLR175W	YLR175W	CBF5	het	Verified	0.205463519440151	0.418604998659776	no	447	0.411493550743338	1358	0.001	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|CELL DIVISION	NUCLEUS|CHROMOSOME|CYTOSKELETON		Pseudouridine synthase catalytic subunit of box H/ACA small nucleolar ribonucleoprotein particles (snoRNPs), acts on both large and small rRNAs and on snRNA U2; mutations in human ortholog dyskerin cause the disorder dyskeratosis congenita	box H/ACA snoRNA 3'-end processing|rRNA pseudouridine synthesis|rRNA processing|snRNA pseudouridine synthesis	pseudouridine synthase activity	box H/ACA snoRNP complex|nucleolus|90S preribosome
YFL029C	YFL029C	CAK1	het	Verified	0.20489703981138	0.418826284022012	no	448	0.432876955338216	1420	0.007	FT	CELL CYCLE|PROTEIN PHOSPHORYLATION			Cyclin-dependent kinase-activating kinase required for passage through the cell cycle, phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases	G2/M transition of mitotic cell cycle|meiosis|G1 phase of mitotic cell cycle|protein phosphorylation	cyclin-dependent protein kinase activating kinase activity	cytoplasm
YLR129W	YLR129W	DIP2	het	Verified	0.197623960381142	0.42166964342053	no	449	0.408127449748644	1360	0.002	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Nucleolar protein, specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	snoRNA binding	small-subunit processome|nucleolus|Pwp2p-containing subcomplex of 90S preribosome|90S preribosome
YDR062W	YDR062W	LCB2	het	Verified	0.195340389721348	0.42256323981341	no	450	0.422255140819684	1428	0.001	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Component of serine palmitoyltransferase, responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine	sphingolipid biosynthetic process	serine C-palmitoyltransferase activity	SPOTS complex|serine C-palmitoyltransferase complex
YOL078W	YOL078W	AVO1	het	Verified	0.193886861536299	0.423132235732159	no	451	0.396856724852381	1307	0.004	FT	SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	PLASMA MEMBRANE		Component of a membrane-bound complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth	TOR signaling cascade|fungal-type cell wall organization|regulation of cell growth|negative regulation of Ras protein signal transduction|establishment or maintenance of actin cytoskeleton polarity	phosphatidylinositol-4,5-bisphosphate binding|Ras GTPase binding	TORC2 complex|plasma membrane|cytoplasm
YDR341C	YDR341C	YDR341C	het	Verified	0.190214804700677	0.424570405218908	no	452	0.43916405808589	1450	0.001	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION	MITOCHONDRION		Arginyl-tRNA synthetase, proposed to be cytoplasmic but the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	cytoplasmic translation|arginyl-tRNA aminoacylation	arginine-tRNA ligase activity	mitochondrion|cytoplasm
YIR011C	YIR011C	STS1	het	Verified	0.189075097536974	0.425016979364159	no	453	0.436172673998519	1450	0.000	FT	PROTEIN LOCALIZATION|PROTEOLYSIS|CHROMOSOME SEGREGATION	NUCLEUS		Protein required for localizing proteasomes to the nucleus; interacts with the karyopherin Srp1p; involved in ubiquitin-mediated protein degradation	proteasome localization|chromosome segregation|nucleus-associated proteasomal ubiquitin-dependent protein catabolic process	molecular_function	nucleus
YAR019C	YAR019C	CDC15	het	Verified	0.189026197956666	0.425036141959254	no	454	0.430851671410979	1410	0.002	FT	CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein kinase of the Mitotic Exit Network; localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II; relocalizes to the cytoplasm upon DNA replication stress	regulation of exit from mitosis|protein phosphorylation|meiotic anaphase II|cytokinesis	protein kinase activity	spindle pole body|cellular bud neck
YBR192W	YBR192W	RIM2	het	Verified	0.187445978581855	0.425655487855562	no	455	0.420277774458646	1355	0.005	FF|FT	ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family	pyrimidine nucleotide transport|mitochondrial genome maintenance|transmembrane transport	pyrimidine nucleotide transmembrane transporter activity|transporter activity	mitochondrion|integral to membrane
YKL078W	YKL078W	DHR2	het	Verified	0.182733082078958	0.427503728518656	no	456	0.425582101361677	1446	0.000	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Predominantly nucleolar DEAH-box ATP-dependent RNA helicase, required for 18S rRNA synthesis	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosome biogenesis	RNA helicase activity	nucleolus
YDL217C	YDL217C	TIM22	het	Verified	0.182308991544776	0.427670121350827	no	457	0.424514414963306	1417	0.004	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Essential core component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; forms the channel through which proteins are imported	protein import into mitochondrial inner membrane	mitochondrion targeting sequence binding|protein channel activity	mitochondrion|integral to membrane|mitochondrial inner membrane protein insertion complex
YJR093C	YJR093C	FIP1	het	Verified	0.178267257771917	0.429256545714486	no	458	0.451315738568834	1514	0.000	FT	RNA PROCESSING	NUCLEUS		Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; bridging factor that links Pap1p and the CPF complex via Yth1p	mRNA cleavage|mRNA polyadenylation	RNA binding|protein binding, bridging	mRNA cleavage and polyadenylation specificity factor complex
YHR101C	YHR101C	BIG1	het	Verified	0.177871987418206	0.429411755403622	no	459	0.421852307496287	1381	0.000	FT	CELL WALL ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Integral membrane protein of the endoplasmic reticulum, required for normal content of cell wall beta-1,6-glucan	fungal-type cell wall biogenesis	molecular_function	integral to endoplasmic reticulum membrane
YPL251W_d	YPL251W	YPL251W	het	Dubious	0.177576370393398	0.429527841636623	no	460	0.413757139368385	1371	0.000					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C	Unknown	Unknown	Unknown
YGR175C	YGR175C	ERG1	het	Verified	0.177404762478353	0.429595233367694	no	461	0.410950128275186	1374	0.000	FT	LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine	ergosterol biosynthetic process	drug binding|squalene monooxygenase activity	endoplasmic reticulum|lipid particle
YMR270C	YMR270C	RRN9	het	Verified	0.177253050970721	0.429654813337267	no	462	0.408317164076901	1372	0.003	FT		NUCLEUS		Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I	transcription of nuclear large rRNA transcript from RNA polymerase I promoter	TBP-class protein binding|RNA polymerase I upstream control element sequence-specific DNA binding transcription factor activity	nucleolus|RNA polymerase I upstream activating factor complex
YGL130W	YGL130W	CEG1	het	Verified	0.173987430431498	0.430937670314698	no	463	0.420957285795373	1361	0.002	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		Alpha (guanylyltransferase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CET1, an RNA 5'-triphosphatase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide	7-methylguanosine mRNA capping|positive regulation of transcription from RNA polymerase II promoter	mRNA guanylyltransferase activity	mRNA cap methyltransferase complex|nucleus
YML010W	YML010W	SPT5	het	Verified	0.171934579084587	0.431744480595373	no	464	0.442763492782638	1476	0.001	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION	NUCLEUS|MITOCHONDRION|CHROMOSOME		Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair	7-methylguanosine mRNA capping|intracellular mRNA localization|mRNA splicing, via spliceosome|positive regulation of transcription elongation from RNA polymerase II promoter|Unknown|regulation of transcription-coupled nucleotide-excision repair	core RNA polymerase I binding transcription factor activity|core RNA polymerase II binding transcription factor activity|rRNA binding|RNA polymerase II core binding|RNA polymerase I transcription factor binding|RNA polymerase I core binding	DSIF complex|mitochondrion|rDNA heterochromatin|nucleus
YDR390C	YDR390C	UBA2	het	Verified	0.171169093716549	0.432045404230142	no	465	0.435230766488715	1458	0.001	FT		NUCLEUS		Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Aos1p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability	protein sumoylation	SUMO activating enzyme activity	SUMO activating enzyme complex|nucleus
YMR296C	YMR296C	LCB1	het	Verified	0.170283500478387	0.432393593233993	no	466	0.422490174265654	1377	0.001	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine	sphingolipid biosynthetic process	serine C-palmitoyltransferase activity	SPOTS complex|serine C-palmitoyltransferase complex
YNL245C	YNL245C	CWC25	het	Verified	0.168967042668573	0.432911282381854	no	467	0.428643611098815	1423	0.000	FT	RNA PROCESSING	NUCLEUS		Splicing factor required for the first step of pre-mRNA splicing; binding to the spliceosome requires Prp2p and Yju2p; heat-stable protein; has similarity to S. pombe Cwf25p	mRNA splicing, via spliceosome	molecular_function	U2-type spliceosomal complex
YFL008W	YFL008W	SMC1	het	Verified	0.168905502111457	0.432935485661761	no	468	0.427895169067766	1391	0.001	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Subunit of the multiprotein cohesin complex, essential protein involved in chromosome segregation and in double-strand DNA break repair; SMC chromosomal ATPase family member, binds DNA with a preference for DNA with secondary structure	double-strand break repair|mitotic sister chromatid cohesion|mitotic sister chromatid segregation	double-stranded DNA binding|ATPase activity|AT DNA binding|DNA secondary structure binding	nuclear mitotic cohesin complex
YDR328C	YDR328C	SKP1	het	Verified	0.167588031255565	0.43345369384967	no	469	0.433082952092419	1416	0.002	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|ION HOMEOSTASIS|CELL DIVISION|PROTEOLYSIS|CYTOSKELETON ORGANIZATION|ION HOMEOSTASIS	NUCLEUS|CHROMOSOME	UBIQUITIN LIGASE COMPLEX|KINETOCHORE	Evolutionarily conserved kinetochore protein; part of multiple protein complexes, including the SCF ubiquitin ligase complex, the CBF3 complex that binds centromeric DNA, and the RAVE complex that regulates assembly of the V-ATPase; protein abundance increases in response to DNA replication stress	kinetochore assembly|protein complex assembly|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of protein complex assembly|G1/S transition of mitotic cell cycle|septin ring assembly|regulation of exit from mitosis|G2/M transition of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|protein neddylation|vacuolar acidification|cytokinesis	ubiquitin-protein ligase activity|DNA replication origin binding|protein binding	RAVE complex|SCF ubiquitin ligase complex|nucleus|CBF3 complex|kinetochore|cytoplasm
YOL094C	YOL094C	RFC4	het	Verified	0.165904028110681	0.434116238727059	no	470	0.427823261985884	1420	0.001	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon	mismatch repair|sister chromatid cohesion|leading strand elongation	DNA clamp loader activity	Elg1 RFC-like complex|Rad17 RFC-like complex|DNA replication factor C complex|Ctf18 RFC-like complex
YGR029W	YGR029W	ERV1	het	Verified	0.164755295316019	0.434568296126149	no	471	0.442339430955114	1457	0.003	FT	PROTEIN LOCALIZATION|ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		Flavin-linked sulfhydryl oxidase of the mitochondrial intermembrane space (IMS), oxidizes Mia40p as part of a disulfide relay system that promotes IMS retention of imported proteins; ortholog of human hepatopoietin (ALR)	cellular response to oxidative stress|cellular iron ion homeostasis|protein import into mitochondrial intermembrane space	thiol oxidase activity|flavin-linked sulfhydryl oxidase activity	mitochondrion|mitochondrial intermembrane space
YML126C	YML126C	ERG13	het	Verified	0.161297052120055	0.435929722464498	no	472	0.423270043250228	1408	0.002	FT	LIPID METABOLISM	ENDOPLASMIC RETICULUM		3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis	ergosterol biosynthetic process	hydroxymethylglutaryl-CoA synthase activity	endoplasmic reticulum
YPL122C	YPL122C	TFB2	het	Verified	0.159282526994858	0.436723143221997	no	473	0.443143123142741	1476	0.000	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION	NUCLEUS	RNA POL II, HOLOENZYME	Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair, similar to 52 kDa subunit of human TFIIH	phosphorylation of RNA polymerase II C-terminal domain|nucleotide-excision repair|transcription from RNA polymerase II promoter	double-stranded DNA binding|core RNA polymerase binding transcription factor activity	core TFIIH complex|holo TFIIH complex|nucleotide-excision repair factor 3 complex
YMR131C	YMR131C	RRB1	het	Verified	0.159114074797171	0.436789499702828	no	474	0.442623575671513	1454	0.001	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Essential nuclear protein involved in early steps of ribosome biogenesis; physically interacts with the ribosomal protein Rpl3p	ribosome biogenesis	molecular_function	nucleolus
YGR090W	YGR090W	UTP22	het	Verified	0.158153569826298	0.437167894558456	no	475	0.436140837437316	1441	0.008	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Component of the small-subunit processome; required for nuclear export of tRNAs; may facilitate binding of Utp8p to aminoacylated tRNAs and their delivery to Los1p for export; conserved from yeast to mammals	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA processing	molecular_function	small-subunit processome|nucleolus|nucleus|UTP-C complex|90S preribosome|CURI complex
YMR301C	YMR301C	ATM1	het	Verified	0.15023927231014	0.440287921343661	no	476	0.442343883040822	1464	0.003	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial inner membrane ATP-binding cassette (ABC) transporter, exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol	cellular iron ion homeostasis	ATPase activity, coupled to transmembrane movement of substances|ATPase activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YLR340W	YLR340W	RPP0	het	Verified	0.14674924648311	0.441664973140041	no	477	0.453058277024814	1493	0.001	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Conserved ribosomal protein P0 of the ribosomal stalk; involved in interaction between translational elongation factors and the ribosome; phosphorylated on serine 302; homologous to mammalian ribosomal protein LP0 and bacterial L10	translational elongation|cytoplasmic translation|ribosomal large subunit assembly	structural constituent of ribosome|LSU rRNA binding	cytosolic large ribosomal subunit|preribosome, large subunit precursor|90S preribosome|cytoplasm
YKL145W	YKL145W	RPT1	het	Verified	0.145412725459519	0.442192508993937	no	478	0.452435437134501	1511	0.001	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS	NUCLEUS		One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and Ubr1p; mutant has aneuploidy tolerance	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of protein catabolic process|proteasome regulatory particle assembly|ubiquitin-dependent protein catabolic process	ATPase activity	proteasome regulatory particle, base subcomplex
YNL038W	YNL038W	GPI15	het	Verified	0.143918990222505	0.442782219885805	no	479	0.439271807293598	1460	0.000	FT	LIPID METABOLISM	ENDOPLASMIC RETICULUM		Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-H protein	GPI anchor biosynthetic process	phosphatidylinositol N-acetylglucosaminyltransferase activity	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|integral to membrane
YOR310C	YOR310C	NOP58	het	Verified	0.143590606386234	0.442911879400665	no	480	0.450162650447428	1505	0.002	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	box C/D snoRNP complex|small-subunit processome|nucleolus|90S preribosome
YPR103W	YPR103W	PRE2	het	Verified	0.141185670468492	0.443861632994904	no	481	0.439834164500946	1453	0.001	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Beta 5 subunit of the 20S proteasome, responsible for the chymotryptic activity of the proteasome	proteasomal ubiquitin-dependent protein catabolic process|proteasome core complex assembly|proteasomal ubiquitin-independent protein catabolic process	endopeptidase activity	nucleus|proteasome storage granule|endoplasmic reticulum membrane|proteasome core complex, beta-subunit complex
YNR035C	YNR035C	ARC35	het	Verified	0.140417248799772	0.444165165148472	no	482	0.456550531490148	1520	0.004	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION	CYTOSKELETON		Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin	mitochondrion inheritance|receptor-mediated endocytosis|microtubule cytoskeleton organization|actin cytoskeleton organization	structural molecule activity	cytosol|Arp2/3 protein complex
YDR468C	YDR468C	TLG1	het	Verified	0.136669873131185	0.44564587189769	no	483	0.432536998105847	1443	0.001	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	GOLGI APPARATUS		Essential t-SNARE that forms a complex with Tlg2p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds the docking complex VFT (Vps fifty-three) through interaction with Vps51p	endocytosis|vesicle fusion	SNAP receptor activity	trans-Golgi network|SNARE complex|endosome
YOR232W	YOR232W	MGE1	het	Verified	0.13535804552595	0.446164396803194	no	484	0.453522359243203	1502	0.004	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial matrix cochaperone, acts as a nucleotide release factor for Ssc1p in protein translocation and folding; also acts as cochaperone for Ssq1p in folding of Fe-S cluster proteins; homolog of E. coli GrpE	protein refolding|protein import into mitochondrial matrix	adenyl-nucleotide exchange factor activity	mitochondrion|presequence translocase-associated import motor|mitochondrial matrix
YPR169W	YPR169W	JIP5	het	Verified	0.130988832334852	0.447892070894731	no	485	0.439128032453389	1446	0.006	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS	NUCLEUS		Essential protein required for biogenesis of the large ribosomal subunit; interacts with proteins involved in RNA processing, ribosome biogenesis, ubiquitination and demethylation; similar to WDR55, a human WD repeat protein	ribosomal large subunit biogenesis	molecular_function	nucleolus|nucleus
YEL019C	YEL019C	MMS21	het	Verified	0.125417367954368	0.450096569518531	no	486	0.448583051621591	1495	0.000	FT	RESPONSE TO DNA DAMAGE	ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME		SUMO ligase and component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; mutants are sensitive to methyl methanesulfonate and show increased spontaneous mutation and mitotic recombination	DNA repair	SUMO ligase activity	nuclear envelope|Smc5-Smc6 complex|nucleus|cytoplasm
YDR118W	YDR118W	APC4	het	Verified	0.125203328335793	0.450181291175108	no	487	0.450914610243936	1520	0.003	FT	CELL CYCLE|CELL DIVISION|PROTEOLYSIS	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to the nucleus increases upon DNA replication stress	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination	ubiquitin-protein ligase activity	anaphase-promoting complex
YER022W	YER022W	SRB4	het	Verified	0.122354834945446	0.451309003086673	no	488	0.44520902420693	1450	0.004	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RNA POL II, HOLOENZYME	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; homozygosity of the human MED17 L371P mutation is associated with infantile cerebral and cerebellar atrophy with poor myelination	transcription initiation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	activating transcription factor binding|structural molecule activity|core RNA polymerase II recruiting transcription factor activity	core mediator complex
YDL165W	YDL165W	CDC36	het	Verified	0.118635038129798	0.452782252477295	no	489	0.467077287143374	1545	0.000	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RNA PROCESSING	NUCLEUS		Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor	response to pheromone involved in conjugation with cellular fusion|regulation of cell cycle|deadenylation-independent decapping of nuclear-transcribed mRNA|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|negative regulation of transcription from RNA polymerase II promoter|nuclear-transcribed mRNA poly(A) tail shortening|transcription elongation from RNA polymerase II promoter|protein ubiquitination	ubiquitin-protein ligase activity	CCR4-NOT core complex|nucleus|cytoplasm
YDR429C	YDR429C	TIF35	het	Verified	0.11833339545702	0.452901748766995	no	490	0.469761841225421	1566	0.000	FF|FT	TRANSLATION			eIF3g subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation	translation reinitiation|translational initiation	translation initiation factor activity	eukaryotic translation initiation factor 3 complex
YLR029C	YLR029C	RPL15A	het	Verified	0.118076766106751	0.453003416306234	no	491	0.472654373659994	1583	0.000	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L15A; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15A has a paralog, RPL15B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YML098W	YML098W	TAF13	het	Verified	0.118033953589011	0.453020377422794	no	492	0.451940446727184	1468	0.000	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RNA POL II, HOLOENZYME	TFIID subunit (19 kDa), involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors	RNA polymerase II transcriptional preinitiation complex assembly|transcription from RNA polymerase II promoter	RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly	nucleus|transcription factor TFIID complex
YGL098W	YGL098W	USE1	het	Verified	0.117919424436972	0.453065751075977	no	493	0.449111632934456	1480	0.001	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Essential SNARE protein localized to the ER, involved in retrograde traffic from the Golgi to the ER; forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p	retrograde vesicle-mediated transport, Golgi to ER|vesicle fusion with endoplasmic reticulum	SNAP receptor activity	SNARE complex|integral to cytosolic side of endoplasmic reticulum membrane
YLL031C	YLL031C	GPI13	het	Verified	0.117326371756493	0.453300713854315	no	494	0.452450107476067	1490	0.000	FT	LIPID METABOLISM|CELL WALL ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		ER membrane localized phosphoryltransferase that adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein	GPI anchor biosynthetic process	mannose-ethanolamine phosphotransferase activity|transferase activity, transferring phosphorus-containing groups	integral to membrane|endoplasmic reticulum
YBR070C	YBR070C	ALG14	het	Verified	0.117297921807005	0.453311985910759	no	495	0.457106166709393	1504	0.002	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Component of UDP-GlcNAc transferase required for the second step of dolichyl-linked oligosaccharide synthesis; anchors the catalytic subunit Alg13p to the ER membrane; similar to bacterial and human glycosyltransferases	dolichol-linked oligosaccharide biosynthetic process	protein anchor|N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity	UDP-N-acetylglucosamine transferase complex|integral to endoplasmic reticulum membrane|nuclear outer membrane-endoplasmic reticulum membrane network|intrinsic to endoplasmic reticulum membrane
YLR459W	YLR459W	GAB1	het	Verified	0.115774414108158	0.453915664357956	no	496	0.435260052151203	1434	0.000	FT	CELL CYCLE|LIPID METABOLISM|CELL DIVISION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		GPI transamidase subunit, involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins; may have a role in recognition of the attachment signal or of the lipid portion of GPI	attachment of GPI anchor to protein	GPI-anchor transamidase activity	integral to membrane|GPI-anchor transamidase complex
YGL120C	YGL120C	PRP43	het	Verified	0.115689766004028	0.453949208666899	no	497	0.455563999152337	1503	0.002	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS|MITOCHONDRION		RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|spliceosomal complex disassembly|ribosomal large subunit biogenesis|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of SSU-rRNA|rRNA processing	ATP-dependent RNA helicase activity	mitochondrion|post-mRNA release spliceosomal complex|90S preribosome
YBR049C	YBR049C	REB1	het	Verified	0.114033962831108	0.454605435296389	no	498	0.461228762626245	1541	0.004	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		RNA polymerase I enhancer binding protein; DNA binding protein that binds to genes transcribed by both RNA polymerase I and RNA polymerase II; required for termination of RNA polymerase I transcription; REB1 has a paralog, NSI1, that arose from the whole genome duplication	termination of RNA polymerase I transcription|regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding	nucleoplasm
YGR047C	YGR047C	TFC4	het	Verified	0.110302891533865	0.456084582073382	no	499	0.459441516229036	1512	0.001	FT		NUCLEUS		One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TFIIIC-102	transcription from a RNA polymerase III hybrid type promoter|transcription from RNA polymerase III type 2 promoter|5S class rRNA transcription from RNA polymerase III type 1 promoter	RNA polymerase III type 1 promoter sequence-specific DNA binding|RNA polymerase III type 2 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity|RNA polymerase III type 2 promoter sequence-specific DNA binding|RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity|DNA binding, bending	transcription factor TFIIIC complex
YDR060W	YDR060W	MAK21	het	Verified	0.109349134897865	0.456462788100769	no	500	0.462582631401534	1546	0.001	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS	NUCLEUS		Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein	ribosomal large subunit assembly	molecular_function	Noc1p-Noc2p complex
YBL018C	YBL018C	POP8	het	Verified	0.107918119830796	0.457030321759724	no	501	0.448360730901224	1496	0.000	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs	tRNA processing|intronic box C/D snoRNA processing|mRNA cleavage|rRNA processing	ribonuclease MRP activity|ribonuclease P activity	nucleolar ribonuclease P complex|ribonuclease MRP complex
YLR314C	YLR314C	CDC3	het	Verified	0.107781363961936	0.457084563082983	no	502	0.443255061996688	1454	0.001	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble with other septins into rod-like complexes that can associate with other rods to form filament polymers; septin rings at the mother-bud neck act as scaffolds for recruiting factors needed for cell division and as barriers to prevent diffusion of specific proteins between mother and daughter cells	septin ring disassembly|maintenance of cell polarity|cell cycle cytokinesis|septin ring assembly	structural molecule activity|GTP binding|1-phosphatidylinositol binding	mating projection base|septin filament array|cellular bud neck septin ring|septin complex|prospore membrane|ascospore wall
YOL077C	YOL077C	BRX1	het	Verified	0.107272775084522	0.457286291113075	no	503	0.441750307269566	1469	0.002	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS	NUCLEUS		Nucleolar protein, constituent of 66S pre-ribosomal particles; depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits; possesses a sigma(70)-like RNA-binding motif	ribosomal large subunit assembly	5S rRNA binding|rRNA primary transcript binding	nucleolus|preribosome, large subunit precursor
YDL196W_d	YDL196W	YDL196W	het	Dubious	0.10575937251706	0.457886635990745	no	504	0.477393589701377	1586	0.001	FF				Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31	Unknown	Unknown	Unknown
YLR005W	YLR005W	SSL1	het	Verified	0.104758053326994	0.458283897718304	no	505	0.476417256252158	1584	0.001	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|TRANSLATION|PROTEIN PHOSPHORYLATION	NUCLEUS	RNA POL II, HOLOENZYME	Component of the core form of RNA polymerase transcription factor TFIIH, which has both protein kinase and DNA-dependent ATPase/helicase activities and is essential for transcription and nucleotide excision repair; interacts with Tfb4p	phosphorylation of RNA polymerase II C-terminal domain|translational initiation|nucleotide-excision repair|transcription from RNA polymerase II promoter	core RNA polymerase binding transcription factor activity	core TFIIH complex|holo TFIIH complex|nucleotide-excision repair factor 3 complex
YDR164C	YDR164C	SEC1	het	Verified	0.10353223707612	0.458770282735908	no	506	0.462721951957239	1546	0.007	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Sm-like protein involved in docking and fusion of exocytic vesicles; binds to assembled SNARE complexes at the membrane and stimulates membrane fusion; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function	positive regulation of vesicle fusion|exocytosis|vesicle docking involved in exocytosis	SNARE binding	plasma membrane|cellular bud neck|cellular bud tip
YFR003C	YFR003C	YPI1	het	Verified	0.0962511392847924	0.461660558019929	no	507	0.454469552001191	1494	0.003	FT	CELL CYCLE|LIPID METABOLISM|ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Regulatory subunit of the type I protein phosphatase (PP1) Glc7p; Glc7p participates in the regulation of a variety of metabolic processes including mitosis and glycogen metabolism; in vitro evidence suggests Ypi1p is an inhibitor of Glc7p while in vivo evidence suggests it is an activator; overproduction causes decreased cellular content of glycogen; partial depletion causes lithium sensitivity, while overproduction confers lithium-tolerance	negative regulation of phosphoprotein phosphatase activity|glycogen metabolic process|cellular ion homeostasis|Unknown|positive regulation of phosphoprotein phosphatase activity|negative regulation of protein dephosphorylation|mitotic cell cycle spindle assembly checkpoint	protein serine/threonine phosphatase inhibitor activity|protein phosphatase type 1 activator activity	nucleus
YJR013W	YJR013W	GPI14	het	Verified	0.0932261251411556	0.462861959952192	no	508	0.462005328706828	1522	0.000	FT	LIPID METABOLISM|CELL WALL ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M	fungal-type cell wall organization|GPI anchor biosynthetic process	mannosyltransferase activity	integral to membrane|endoplasmic reticulum membrane
YIL147C	YIL147C	SLN1	het	Verified	0.0932211679327995	0.462863929017355	no	509	0.454251352781492	1494	0.000	FT	SIGNALING|PROTEIN PHOSPHORYLATION	PLASMA MEMBRANE		Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators	negative regulation of protein kinase activity|protein autophosphorylation|peptidyl-histidine phosphorylation|osmosensory signaling pathway via two-component system	osmosensor activity|protein histidine kinase activity|histidine phosphotransfer kinase activity	plasma membrane|integral to plasma membrane
YIL022W	YIL022W	TIM44	het	Verified	0.0927368596230038	0.463056306715255	no	510	0.45677419174978	1522	0.001	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex)	protein import into mitochondrial matrix	protein binding, bridging|chaperone binding	mitochondrion|integral to membrane|presequence translocase-associated import motor
YDR211W	YDR211W	GCD6	het	Verified	0.0919412277155383	0.463372367591771	no	511	0.463816988260898	1546	0.003	FT	TRANSLATION			Catalytic epsilon subunit of the translation initiation factor eIF2B; eIF2B is the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression; forms cytoplasmic foci upon DNA replication stress	regulation of translational initiation	guanyl-nucleotide exchange factor activity|translation initiation factor activity	eukaryotic translation initiation factor 2B complex|guanyl-nucleotide exchange factor complex
YDL092W	YDL092W	SRP14	het	Verified	0.0890987450447533	0.464501717369407	no	512	0.453910265868107	1495	0.001	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION	NUCLEUS		Signal recognition particle (SRP) subunit, interacts with the RNA component of SRP to form the Alu domain, which is the region of SRP responsible for arrest of nascent chain elongation during membrane targeting; homolog of mammalian SRP14	SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition|protein targeting to ER	signal sequence binding	signal recognition particle, endoplasmic reticulum targeting
YAL043C	YAL043C	PTA1	het	Verified	0.0883392716087997	0.46480351335885	no	513	0.46922767525514	1536	0.002	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII	tRNA processing|termination of RNA polymerase II transcription, exosome-dependent|mRNA cleavage|termination of RNA polymerase II transcription, poly(A)-coupled|mRNA polyadenylation	RNA binding	mRNA cleavage factor complex|mRNA cleavage and polyadenylation specificity factor complex
YLR010C	YLR010C	TEN1	het	Verified	0.0861625609776588	0.465668595999899	no	514	0.470953332507695	1581	0.007	FT		NUCLEUS|CHROMOSOME		Protein that regulates telomeric length; protects telomeric ends in a complex with Cdc13p and Stn1p	negative regulation of telomere maintenance|telomere capping|telomere maintenance via telomerase	single-stranded telomeric DNA binding	nuclear telomere cap complex
YNL158W	YNL158W	PGA1	het	Verified	0.0789089893282946	0.468552506544816	no	515	0.463014945093944	1543	0.000	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Essential component of GPI-mannosyltransferase II, responsible for second mannose addition to GPI precursors as a partner of Gpi18p; required for maturation of Gas1p and Pho8p; has synthetic genetic interations with secretory pathway genes	GPI anchor biosynthetic process	mannosyltransferase activity	integral to endoplasmic reticulum membrane|nuclear envelope|mannosyltransferase complex
YLR078C	YLR078C	BOS1	het	Verified	0.0788346380607349	0.468582076292659	no	516	0.467921220255903	1541	0.000	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi	ER to Golgi vesicle-mediated transport|vesicle fusion with Golgi apparatus|vesicle fusion	SNAP receptor activity	SNARE complex|integral to membrane|ER to Golgi transport vesicle membrane|endoplasmic reticulum membrane
YKL088W	YKL088W	CAB3	het	Verified	0.0784444258654059	0.468737267826186	no	517	0.450369299983576	1469	0.005	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			Subunit of a phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaBC	response to salt stress|coenzyme A biosynthetic process	phosphopantothenoylcysteine decarboxylase activity|purine nucleotide binding	phosphopantothenoylcysteine decarboxylase complex|cytoplasm
YKL035W	YKL035W	UGP1	het	Verified	0.0738622112314044	0.4705600123746	no	518	0.463817023290298	1541	0.002	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			UDP-glucose pyrophosphorylase (UGPase); catalyses the reversible formation of UDP-Glc from glucose 1-phosphate and UTP, involved in a wide variety of metabolic pathways, expression modulated by Pho85p through Pho4p; UGP1 has a paralog, YHL012W, that arose from the whole genome duplication	(1->6)-beta-D-glucan biosynthetic process|UDP-glucose metabolic process|trehalose biosynthetic process|glycogen biosynthetic process	UTP:glucose-1-phosphate uridylyltransferase activity	plasma membrane|cytoplasm
YMR236W	YMR236W	TAF9	het	Verified	0.0720051928562765	0.471298887639593	no	519	0.471326981845072	1569	0.004	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS	RNA POL II, HOLOENZYME|HISTONE ACETYLTRANSFERASE	Subunit (17 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H3	histone acetylation|RNA polymerase II transcriptional preinitiation complex assembly|chromatin modification|transcription from RNA polymerase II promoter	chromatin binding|protein complex scaffold|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly	SLIK (SAGA-like) complex|SAGA complex|transcription factor TFIID complex
YNL282W	YNL282W	POP3	het	Verified	0.068012785768484	0.472887728140944	no	520	0.473479969260891	1588	0.000	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs	tRNA processing|intronic box C/D snoRNA processing|mRNA cleavage|rRNA processing	ribonuclease MRP activity|ribonuclease P activity	nucleolar ribonuclease P complex|ribonuclease MRP complex
YGL069C_d	YGL069C	YGL069C	het	Dubious	0.0677300905937082	0.473000247736997	no	521	0.480079456460606	1604	0.001					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 92% of ORF overlaps the uncharacterized ORF YGL068W; deletion in cyr1 mutant results in loss of stress resistance	Unknown	Unknown	Unknown
YPR105C	YPR105C	COG4	het	Verified	0.066365093984546	0.473543579939137	no	522	0.475516222525743	1567	0.000	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments	peroxisome degradation|intra-Golgi vesicle-mediated transport|retrograde transport, vesicle recycling within Golgi|macroautophagy|CVT pathway	molecular_function	Golgi transport complex
YLR106C	YLR106C	MDN1	het	Verified	0.065967156844223	0.473701986759464	no	523	0.467742788739321	1546	0.003	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEOTIDE METABOLISM	NUCLEUS|MITOCHONDRION		Huge dynein-related AAA-type ATPase (midasin), forms extended pre-60S particle with the Rix1 complex (Rix1p-Ipi1p-Ipi3p); acts in removal of ribosomal biogenesis factors at successive steps of pre-60S assembly and export from nucleus	ribosomal large subunit assembly|rRNA processing	ATPase activity	nucleoplasm|mitochondrion|nucleus
YBR193C	YBR193C	MED8	het	Verified	0.0627980297397414	0.474963667407095	no	524	0.473919587069988	1576	0.002	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RNA POL II, HOLOENZYME	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation	negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	TBP-class protein binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II transcription corepressor activity|structural molecule activity	core mediator complex
YKL196C	YKL196C	YKT6	het	Verified	0.0605061286528896	0.475876267417965	no	525	0.463132573697966	1543	0.005	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	MITOCHONDRION|GOLGI APPARATUS|PLASMA MEMBRANE		Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminus	intra-Golgi vesicle-mediated transport|vacuole fusion, non-autophagic|vesicle fusion	palmitoyltransferase activity|SNAP receptor activity	SNARE complex|endosome|mitochondrion|Golgi apparatus|fungal-type vacuole|membrane
YPR182W	YPR182W	SMX3	het	Verified	0.0556263449405912	0.477819738382986	no	526	0.454821784476076	1493	0.000	FT	RNA PROCESSING	NUCLEUS		Core Sm protein Sm F; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm F	mRNA splicing, via spliceosome	molecular_function	U1 snRNP|U4/U6 x U5 tri-snRNP complex|U5 snRNP
YLR291C	YLR291C	GCD7	het	Verified	0.0554416490479973	0.477893307850909	no	527	0.46324066790298	1536	0.001	FT	TRANSLATION	MITOCHONDRION		Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression	regulation of translational initiation	enzyme regulator activity|translation initiation factor activity|guanyl-nucleotide exchange factor activity	mitochondrion|eukaryotic translation initiation factor 2B complex|guanyl-nucleotide exchange factor complex
YGR277C	YGR277C	CAB4	het	Verified	0.0542492713590376	0.478368282791538	no	528	0.478341163164635	1602	0.001	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	NUCLEUS		Probable pantetheine-phosphate adenylyltransferase (PPAT), which catalyzes the fourth step in the biosynthesis of coenzyme A from pantothenate; null mutant lethality is complemented by E. coli coaD (encoding PPAT); widely conserved	coenzyme A biosynthetic process	pantetheine-phosphate adenylyltransferase activity	nucleus|cytoplasm
YPR055W	YPR055W	SEC8	het	Verified	0.0534915905480251	0.478670115414336	no	529	0.4792516837476	1596	0.003	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Essential 121 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in ER and Golgi inheritance in small buds; relocalizes away from bud neck upon DNA replication stress	Golgi inheritance|endoplasmic reticulum inheritance|Golgi to plasma membrane transport|exocytosis|vesicle fusion|vesicle docking involved in exocytosis	molecular_function	incipient cellular bud site|cellular bud neck|mating projection tip|exocyst|cellular bud tip
YML091C	YML091C	RPM2	het	Verified	0.050445149598806	0.479883828992837	no	530	0.493283493205121	1649	0.006	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|TRANSLATION|MITOCHONDRION ORGANIZATION	NUCLEUS|MITOCHONDRION		Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus	cytoplasmic translation|tRNA 5'-leader removal|mRNA processing|mitochondrion organization|RNA processing|positive regulation of transcription from RNA polymerase II promoter	ribonuclease P activity	mitochondrion|nucleus|mitochondrial matrix|cytoplasmic mRNA processing body|mitochondrial ribonuclease P complex
YGR009C	YGR009C	SEC9	het	Verified	0.0447783083674637	0.482142007580903	no	531	0.481243264213929	1604	0.001	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	PLASMA MEMBRANE		t-SNARE protein important for fusion of secretory vesicles with the plasma membrane; similar to but not functionally redundant with Spo20p; SNAP-25 homolog	Golgi to plasma membrane transport|vesicle fusion	SNAP receptor activity	SNARE complex|extrinsic to plasma membrane
YKL153W_d	YKL153W	YKL153W	het	Dubious	0.0441504467807055	0.482392240622209	no	532	0.482691567910311	1614	0.003					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLK153W and the overlapping essential gene GPM1 is reduced in the gcr1 null mutant	Unknown	Unknown	Unknown
YOL038W	YOL038W	PRE6	het	Verified	0.0415405279010555	0.483432492065017	no	533	0.493838339870004	1650	0.000	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION		Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress	proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process	molecular_function	mitochondrion|proteasome core complex, alpha-subunit complex|proteasome storage granule|nucleus|nuclear outer membrane-endoplasmic reticulum membrane network
YPL011C	YPL011C	TAF3	het	Verified	0.0414878827765301	0.483453476340794	no	534	0.46405929820282	1561	0.007	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RNA POL II, HOLOENZYME	TFIID subunit (47 kDa), involved in promoter binding and RNA polymerase II transcription initiation	RNA polymerase II transcriptional preinitiation complex assembly|transcription from RNA polymerase II promoter	chromatin binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly	transcription factor TFIID complex
YOL066C	YOL066C	RIB2	het	Verified	0.0348980862436602	0.486080503320778	no	535	0.498354852360776	1682	0.010	FT	RNA PROCESSING			Bifunctional enzyme with DRAP deaminase and tRNA:pseudouridine synthase activity; the deaminase catalyzes the third step in riboflavin biosynthesis and the synthase catalyzes formation of pseudouridine at position 32 in cytoplasmic tRNAs	riboflavin biosynthetic process|tRNA pseudouridine synthesis	pseudouridine synthase activity|2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase activity	cytoplasm
YGR002C	YGR002C	SWC4	het	Verified	0.0246011653691001	0.490186544875965	no	536	0.499940099830783	1678	0.001	FT	CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME	HISTONE ACETYLTRANSFERASE	Component of the Swr1p complex that incorporates Htz1p into chromatin; component of the NuA4 histone acetyltransferase complex	DNA repair|histone acetylation|chromosome organization|chromatin modification|chromatin remodeling|histone exchange|establishment of mitotic sister chromatid cohesion	DNA binding	Swr1 complex|histone acetyltransferase complex|nucleus|NuA4 histone acetyltransferase complex
YGL048C	YGL048C	RPT6	het	Verified	0.0235362373911119	0.490611266612928	no	537	0.477951952320842	1594	0.000	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEOLYSIS	NUCLEUS		ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; bound by ubiquitin-protein ligases Ubr1p and Ufd4p; localized mainly to the nucleus throughout the cell cycle; protein abundance increases in response to DNA replication stress	proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|nucleotide-excision repair|proteasome regulatory particle assembly|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|negative regulation of sequence-specific DNA binding transcription factor activity|chromatin remodeling	ATPase activity|protein domain specific binding	proteasome regulatory particle, base subcomplex|proteasome storage granule|nucleus
YLR045C	YLR045C	STU2	het	Verified	0.0234198719157046	0.490657676928133	no	538	0.487893862990456	1628	0.001	FT	CELL CYCLE|CYTOSKELETON ORGANIZATION	NUCLEUS|CHROMOSOME|CYTOSKELETON	KINETOCHORE	Microtubule-associated protein (MAP) of the XMAP215/Dis1 family; regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment; interacts with spindle pole body component Spc72p	microtubule nucleation|mitotic spindle organization in nucleus	microtubule binding|structural constituent of cytoskeleton	cell cortex|spindle microtubule|condensed nuclear chromosome kinetochore|spindle pole body|kinetochore
YJL034W	YJL034W	KAR2	het	Verified	0.0228670214439435	0.490878173294307	no	539	0.49770891784926	1665	0.000	FT	PROTEIN LOCALIZATION|PROTEOLYSIS	ENDOPLASMIC RETICULUM		ATPase involved in protein import into the ER, also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins; regulates the unfolded protein response via interaction with Ire1p	karyogamy involved in conjugation with cellular fusion|posttranslational protein targeting to membrane, translocation|ER-associated protein catabolic process|SRP-dependent cotranslational protein targeting to membrane, translocation|response to unfolded protein	unfolded protein binding|ATPase activity	endoplasmic reticulum|luminal surveillance complex
YKL058W	YKL058W	TOA2	het	Verified	0.0224029573462563	0.491063260661872	no	540	0.499071458709325	1674	0.005	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RNA POL II, HOLOENZYME	TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA; protein abundance increases in response to DNA replication stress	transcription initiation from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly	TBP-class protein binding|TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly|TBP-class protein binding RNA polymerase II transcription factor activity	transcription factor TFIIA complex
YHR164C	YHR164C	DNA2	het	Verified	0.0172142819855696	0.493132834250471	no	541	0.488544873607032	1620	0.000	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Tripartite DNA replication factor; has single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; required for Okazaki fragment processing; involved in DNA repair; cell-cycle dependent localization; forms nuclear foci upon DNA replication stress	DNA repair|lagging strand elongation|meiotic DNA double-strand break processing|DNA strand renaturation|replicative cell aging|telomere maintenance|DNA-dependent DNA replication	ATP-dependent DNA helicase activity|single-stranded DNA specific endodeoxyribonuclease activity|5'-flap endonuclease activity	nuclear chromosome, telomeric region|nucleus|cytoplasm
YPR088C	YPR088C	SRP54	het	Verified	0.0169237284429741	0.493248731458315	no	542	0.484724407292755	1732	0.004	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS			Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain	SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition|SRP-dependent cotranslational protein targeting to membrane|protein targeting to ER	7S RNA binding|GTP binding|signal sequence binding	signal recognition particle, endoplasmic reticulum targeting
YDR381W	YDR381W	YRA1	het	Verified	0.0130710473938447	0.494785555029189	no	543	0.498664417252523	1674	0.008	FT	RESPONSE TO DNA DAMAGE|RNA LOCALIZATION	NUCLEUS		RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member	mRNA export from nucleus|transcription-coupled nucleotide-excision repair	RNA binding	transcription export complex
YOR260W	YOR260W	GCD1	het	Verified	0.0048269608952863	0.498074328690909	no	544	0.494840353600588	1651	0.002	FT	TRANSLATION			Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression	regulation of translational initiation	translation initiation factor activity|guanyl-nucleotide exchange factor activity	eukaryotic translation initiation factor 2B complex|guanyl-nucleotide exchange factor complex
YKL018W	YKL018W	SWD2	het	Verified	0.00306113204488751	0.498778786908639	no	545	0.47157076038181	1547	0.002	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination	mRNA 3'-end processing|termination of RNA polymerase II transcription, exosome-dependent|histone H3-K4 methylation|termination of RNA polymerase II transcription, poly(A)-coupled|telomere maintenance|snoRNA 3'-end processing|histone H3-K79 methylation	histone methyltransferase activity (H3-K4 specific)	mRNA cleavage and polyadenylation specificity factor complex|Set1C/COMPASS complex
YLR440C	YLR440C	SEC39	het	Verified	0.000870760869270738	0.499652616717028	no	546	0.495783062885451	1698	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PEROXISOME ORGANIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Component of the Dsl1p tethering complex that interacts with ER SNAREs Sec20p and Use1p; proposed to be involved in protein secretion; localizes to the ER and nuclear envelope	retrograde vesicle-mediated transport, Golgi to ER|vesicle-mediated transport|ER-dependent peroxisome organization	molecular_function	Dsl1p complex|nuclear envelope|endoplasmic reticulum|peroxisome|endoplasmic reticulum membrane
YLR116W	YLR116W	MSL5	het	Verified	-0.000870760869270738	0.499652616717028	no	547	0.487260660690015	1738	NA	FT	RNA PROCESSING	NUCLEUS		Component of the commitment complex, which defines the first step in the splicing pathway; essential protein that interacts with Mud2p and Prp40p, forming a bridge between the intron ends; also involved in nuclear retention of pre-mRNA	mRNA splicing, via spliceosome	pre-mRNA branch point binding	commitment complex
YLR132C	YLR132C	USB1	het	Verified	-0.00354681702343554	0.498585027695209	no	548	0.491692580476451	1723	NA	FT	RNA PROCESSING	NUCLEUS|MITOCHONDRION		Putative phosphodiesterase specific for U6 snRNA 3' end modification; trims the 3' poly(u) tract to leave a terminal 3' phosphate; human homolog, hUSB1 (aka C16orf57) produces a 2',3' cyclic phosphate; mutations in hUSB1 are associated with a rare skin condition (OMIM 604173); essential protein that localizes to the nucleus and mitochondria; overexpression suppresses the respiratory defects of oxa1 and mtf2 mutants	U6 snRNA 3'-end processing	phosphoric diester hydrolase activity	mitochondrion|nucleus|cytoplasm
YGL238W	YGL238W	CSE1	het	Verified	-0.00926550270091856	0.4963036521118	no	549	0.492927102479349	1711	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION	ENDOMEMBRANE SYSTEM|NUCLEUS		Nuclear envelope protein that mediates the nuclear export of importin alpha (Srp1p), homolog of metazoan CAS protein, required for accurate chromosome segregation	protein export from nucleus	importin-alpha export receptor activity	nuclear envelope|integral to membrane
YDL221W_d	YDL221W	YDL221W	het	Dubious	-0.0117463214573621	0.495314003490948	no	550	0.489383717688872	1714	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 3' end of essential gene CDC13	Unknown	Unknown	Unknown
YJL143W	YJL143W	TIM17	het	Verified	-0.0118215412243292	0.495283997229013	no	551	0.487269385782894	1731	NA	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Essential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); with Tim23p, contributes to the architecture and function of the import channel; may link the import motor to the core TIM23 complex	protein import into mitochondrial matrix|mitochondrial genome maintenance	protein channel activity	mitochondrion|integral to membrane|mitochondrial inner membrane presequence translocase complex
YKL099C	YKL099C	UTP11	het	Verified	-0.0131097859087155	0.4947701019218	no	552	0.493641182974042	1660	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	small-subunit processome|nucleolus
YNL272C	YNL272C	SEC2	het	Verified	-0.0194218586615128	0.492252286503023	no	553	0.490032066985374	1728	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	SITE OF POLARIZED GROWTH		Guanyl-nucleotide exchange factor for the small G-protein Sec4p; essential for post-Golgi vesicle transport and for autophagy; associates with the exocyst, via exocyst subunit Sec15p, on secretory vesicles	autophagy|exocytosis	guanyl-nucleotide exchange factor activity|phosphatidylinositol-4-phosphate binding	cytosol|transport vesicle|mating projection tip|cellular bud neck|cellular bud tip
YJR023C_d	YJR023C	YJR023C	het	Dubious	-0.0198513862552135	0.492080962820741	no	554	0.494685291433	1657	NA					Putative protein of unknown function; open reading frame overlaps LSM8/YJR022W encoding an essential snRNP protein required for RNA processing and splicing	Unknown	Unknown	Unknown
YGL233W	YGL233W	SEC15	het	Verified	-0.0240683132485129	0.490399059180928	no	555	0.493003647734741	1709	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Essential 113 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; interacts with and functions as a downstream effector of active, GTP-bound Sec4p, a Rab family GTPase	Golgi to plasma membrane transport|exocytosis|vesicle fusion|vesicle docking involved in exocytosis	Rab GTPase binding	incipient cellular bud site|cellular bud neck|mating projection tip|cellular bud tip|exocyst
YPR113W	YPR113W	PIS1	het	Verified	-0.0287590594704946	0.488528376586178	no	556	0.492861885913643	1702	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS		Phosphatidylinositol synthase, required for biosynthesis of phosphatidylinositol, which is a precursor for polyphosphoinositides, sphingolipids, and glycolipid anchors for some of the plasma membrane proteins	phosphatidylinositol biosynthetic process	CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity	mitochondrial outer membrane|mitochondrion|integral to membrane|Golgi apparatus
YKL036C_d	YKL036C	YKL036C	het	Dubious	-0.0339269170317848	0.486467714426101	no	557	0.489912582360857	1730	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species; partially overlaps the essential gene UGP1 gene and uncharacterized ORF YKL037W	Unknown	Unknown	Unknown
YLR002C	YLR002C	NOC3	het	Verified	-0.0355815229048316	0.485808020788873	no	558	0.49226776915216	1707	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|CELL DIVISION	NUCLEUS		Component of a nuclear complex with Noc2p and pre-replicative complexes; the Noc2p-Noc3p complex binds to 66S ribosomal precursors to mediate their maturation and intranuclear transport; binds to chromatin at active replication origins, and is required for pre-RC formation and maintenance during DNA replication licensing	rRNA processing|DNA replication initiation	chromatin binding	nucleoplasm|nucleolus|Noc2p-Noc3p complex|nucleus
YOL146W	YOL146W	PSF3	het	Verified	-0.0364587432947047	0.485458287451693	no	559	0.484017859701831	1749	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery	double-strand break repair via break-induced replication|DNA-dependent DNA replication	molecular_function	replication fork protection complex|GINS complex|DNA replication preinitiation complex
YML023C	YML023C	NSE5	het	Verified	-0.0366861508299499	0.485367625623563	no	560	0.476116518109979	1792	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair	DNA repair	molecular_function	Smc5-Smc6 complex|nucleus
YKL083W_d	YKL083W	YKL083W	het	Dubious	-0.0376572856422083	0.484980466470597	no	561	0.498817494834649	1675	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species; partially overlaps the verified essential gene RRP14	Unknown	Unknown	Unknown
YML092C	YML092C	PRE8	het	Verified	-0.0400442008855651	0.484028943661908	no	562	0.454385014525104	1854	NA	FF|FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION		Alpha 2 subunit of the 20S proteasome	proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process	molecular_function	mitochondrion|proteasome core complex, alpha-subunit complex|proteasome storage granule|nucleus|nuclear outer membrane-endoplasmic reticulum membrane network
YPL012W	YPL012W	RRP12	het	Verified	-0.0440761516580642	0.482421851262926	no	563	0.478907538040877	1772	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS	RIBOSOME	Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; has a role in nuclear import in association with Pse1p; contains HEAT-repeats	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosome biogenesis	molecular_function	ribosome|nucleus|90S preribosome
YNR003C	YNR003C	RPC34	het	Verified	-0.044211928316141	0.482367736965229	no	564	0.478148819307009	1781	NA	FT		NUCLEUS|MITOCHONDRION		RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex	tRNA transcription from RNA polymerase III promoter	DNA-directed RNA polymerase activity	mitochondrion|DNA-directed RNA polymerase III complex|nucleus|cytoplasm
YLR195C	YLR195C	NMT1	het	Verified	-0.0467394827936916	0.481360430999075	no	565	0.476459729899686	1761	NA					N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction	N-terminal peptidyl-glycine N-myristoylation|replicative cell aging	glycylpeptide N-tetradecanoyltransferase activity	cytosol
YJR065C	YJR065C	ARP3	het	Verified	-0.0471299427234402	0.481204831502219	no	566	0.462689761303839	1813	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION	CYTOSKELETON		Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity	mitochondrion inheritance|Arp2/3 complex-mediated actin nucleation|actin filament organization	ATP binding	Arp2/3 protein complex|plasma membrane
YGR198W	YGR198W	YPP1	het	Verified	-0.0490545837117894	0.480437898375322	no	567	0.471416293005906	1773	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	PLASMA MEMBRANE|CYTOSKELETON		Cargo-transport protein involved in endocytosis; interacts with phosphatidylinositol-4-kinase Stt4; GFP-fusion protein localizes to the cytoplasm; YGR198W is an essential gene	receptor-mediated endocytosis|response to pheromone|protein targeting to vacuole	molecular_function	endosome|cytosol|ribosome|plasma membrane|actin cortical patch|cytoplasm
YNL113W	YNL113W	RPC19	het	Verified	-0.0572173483282785	0.477186029415713	no	568	0.47247045927054	1797	NA	FT		NUCLEUS		RNA polymerase subunit AC19, common to RNA polymerases I and III	tRNA transcription from RNA polymerase III promoter|transcription from RNA polymerase I promoter	DNA-directed RNA polymerase activity	DNA-directed RNA polymerase I complex|DNA-directed RNA polymerase III complex
YIL063C	YIL063C	YRB2	het	Verified	-0.0630231096092111	0.474874051045585	no	569	0.468377880073621	1796	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|GENE SILENCING	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Protein of unknown function involved in nuclear processes of the Ran-GTPase cycle; involved in nuclear protein export; contains Ran Binding Domain and FxFG repeats; interacts with Srm1p, GTP-Gsp1p, Rna1p and Crm1p; is not essential	protein export from nucleus|regulation of chromatin silencing at telomere|ribosomal small subunit export from nucleus	molecular_function	integral to membrane|nucleus|nuclear pore
YJR068W	YJR068W	RFC2	het	Verified	-0.0631740292898318	0.47481396254231	no	570	0.478169048679678	1756	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon	mismatch repair|sister chromatid cohesion|cell cycle checkpoint|leading strand elongation	DNA clamp loader activity|purine nucleotide binding	Elg1 RFC-like complex|DNA replication factor C complex|Rad17 RFC-like complex|Ctf18 RFC-like complex
YPL231W	YPL231W	FAS2	het	Verified	-0.0646547038732251	0.474224464195727	no	571	0.473743464975288	1786	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Alpha subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains the acyl-carrier protein domain and beta-ketoacyl reductase, beta-ketoacyl synthase and self-pantetheinylation activities	fatty acid biosynthetic process	holo-[acyl-carrier-protein] synthase activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|fatty acid synthase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	cytosol|fatty acid synthase complex|mitochondrion|cytoplasm
YDL030W	YDL030W	PRP9	het	Verified	-0.0652623615069588	0.473982554797892	no	572	0.474960936354891	1764	NA	FT	RNA PROCESSING	NUCLEUS		Subunit of the SF3a splicing factor complex, required for spliceosome assembly; acts after the formation of the U1 snRNP-pre-mRNA complex	mRNA splicing, via spliceosome	RNA binding	U2 snRNP|U2-type prespliceosome
YDR044W	YDR044W	HEM13	het	Verified	-0.0681738992338357	0.472823602007134	no	573	0.474573844779852	1782	NA	FT	OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM			Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)	heme biosynthetic process	coproporphyrinogen oxidase activity	cytosol
YDR398W	YDR398W	UTP5	het	Verified	-0.0700523184479519	0.472076008890591	no	574	0.490587419460972	1725	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS|CHROMOSOME		Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit	positive regulation of transcription from RNA polymerase I promoter|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	small-subunit processome|t-UTP complex|rDNA heterochromatin|nucleolus
YPL124W	YPL124W	SPC29	het	Verified	-0.0773524221336269	0.469171594479699	no	575	0.484018365208329	1745	NA	FT	CELL CYCLE|CYTOSKELETON ORGANIZATION	NUCLEUS|CYTOSKELETON		Inner plaque spindle pole body (SPB) component, links the central plaque component Spc42p to the inner plaque component Spc110p; required for SPB duplication	microtubule nucleation|spindle pole body duplication associated with nuclear envelope	structural constituent of cytoskeleton	central plaque of spindle pole body
YNL216W	YNL216W	RAP1	het	Verified	-0.0790315046837307	0.46850378215663	no	576	0.466685095125146	1809	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|GENE SILENCING	NUCLEUS|CHROMOSOME		Essential DNA-binding transcription regulator that binds at many loci; involved in either transcription activation or repression, chromatin silencing, and telomere length maintenance; conserved protein with an N-terminal BRCT domain, a central region with homology to the Myb DNA binding domain, and a C-terminal Rap1-specific protein-interaction domain (RCT domain)	negative regulation of chromatin silencing|establishment of protein localization to chromatin|establishment of chromatin silencing at telomere|regulation of transcription by chromatin organization|protection from non-homologous end joining at telomere|negative regulation of transcription from RNA polymerase II promoter|telomere maintenance via telomere lengthening|telomere maintenance|regulation of glycolysis by positive regulation of transcription from RNA polymerase II promoter|establishment of protein localization to telomere|positive regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette|chromatin silencing at telomere	core promoter proximal region sequence-specific DNA binding|DNA binding, bending|sequence-specific DNA binding|TFIID-class transcription factor binding|TBP-class protein binding RNA polymerase II transcription factor activity|telomeric DNA binding|RNA polymerase II transcription factor binding transcription factor activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|G-quadruplex DNA binding|nucleosomal DNA binding	nuclear chromosome|nuclear nucleosome|nuclear chromosome, telomeric region|nuclear telomere cap complex
YOR272W	YOR272W	YTM1	het	Verified	-0.0845724057314576	0.466300668743505	no	577	0.473434974332213	1775	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Erb1p that is required for maturation of the large ribosomal subunit; has seven C-terminal WD repeats	chromosome organization|ribosomal large subunit biogenesis	molecular_function	PeBoW complex|nucleolus|nucleus|preribosome, large subunit precursor
YLR208W	YLR208W	SEC13	het	Verified	-0.0909466307399985	0.463767498860355	no	578	0.473147504174125	1805	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	NUCLEAR PORE	Structural component of 3 distinct complexes; subunit of Nup84 nuclear pore sub-complex (NPC), COPII vesicle coat, and Seh1-associated (SEA) complex; COPII vesicle coat is required for ER to Golgi transport; the Nup84 subcomplex contributes to nucleocytoplasmic transport, NPC biogenesis and processes that may require localization of chromosomes at the nuclear periphery, including transcription; homologous to human SEC13; abundance increases under DNA replication stress	positive regulation of transcription, DNA-dependent|ER-associated protein catabolic process|positive regulation of GTPase activity|nuclear pore distribution|COPII-coated vesicle budding	structural molecule activity	COPII vesicle coat|nuclear pore outer ring|Seh1-associated complex
YPR177C_d	YPR177C	YPR177C	het	Dubious	-0.100742705145114	0.459877354998594	no	579	0.468609701190208	1812	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 5' end of the essential PRP4 gene encoding a component of the U4/U6-U5 snRNP complex	Unknown	Unknown	Unknown
YBR155W	YBR155W	CNS1	het	Verified	-0.100834321368114	0.459840990584297	no	580	0.453865348165292	1862	NA					TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion	protein folding	Hsp70 protein binding|Hsp90 protein binding	cytoplasm
YLR117C	YLR117C	CLF1	het	Verified	-0.101698255066537	0.459498093610752	no	581	0.45648046315685	1849	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING	NUCLEUS|CHROMOSOME		Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins	cis assembly of pre-catalytic spliceosome|DNA replication initiation	DNA replication origin binding|chromatin binding|first spliceosomal transesterification activity|second spliceosomal transesterification activity	chromatin|U2-type post-mRNA release spliceosomal complex|Prp19 complex|U2-type prespliceosome|U2-type catalytic step 2 spliceosome|U2-type catalytic step 1 spliceosome
YIL150C	YIL150C	MCM10	het	Verified	-0.102817351133512	0.459053967017657	no	582	0.451767448475465	1859	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS|CHROMOSOME		Essential chromatin-associated protein involved in the initiation of DNA replication; required for the association of the MCM2-7 complex with replication origins	S phase of mitotic cell cycle|DNA strand elongation involved in DNA replication|double-strand break repair via break-induced replication|DNA replication initiation|chromatin silencing at telomere|chromatin silencing at silent mating-type cassette	double-stranded DNA binding|protein binding|DNA replication origin binding|single-stranded DNA binding	replication fork protection complex|replication fork|nucleus
YHR072W	YHR072W	ERG7	het	Verified	-0.104527913553566	0.458375208897296	no	583	0.447974830595257	1866	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis	ergosterol biosynthetic process	lanosterol synthase activity	endoplasmic reticulum|lipid particle|plasma membrane
YMR185W	YMR185W	RTP1	het	Verified	-0.104661409754513	0.458322242141663	no	584	0.455263776924516	1846	NA					Protein required for the nuclear import and biogenesis of RNA pol II; conflicting evidence on whether null mutant is viable with elongated buds, or inviable; interacts with Rpb2, Rpb3, Nup116p, Nup100p and components of the R2TP complex (Rvb1p, Rvb2p, Pih1p); similar to human TMCO7 gene	biological_process	molecular_function	cellular_component
YLR100W	YLR100W	ERG27	het	Verified	-0.109778621328347	0.456292473131251	no	585	0.451826895398515	1859	NA	FT	LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		3-keto sterol reductase, catalyzes the last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants are sterol auxotrophs	ergosterol biosynthetic process	3-keto sterol reductase activity	mitochondrial outer membrane|endoplasmic reticulum|endoplasmic reticulum membrane
YFR002W	YFR002W	NIC96	het	Verified	-0.12085892854113	0.451901386954842	no	586	0.464638489954285	1809	NA	FF|FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup57p, and Nup49p)	ribosomal large subunit export from nucleus|protein import into nucleus|nuclear pore organization	structural constituent of nuclear pore	integral to membrane|nuclear pore nuclear basket|nuclear pore linkers|nuclear pore
YDR196C	YDR196C	CAB5	het	Verified	-0.123345188340434	0.450916879442866	no	587	0.441980364802258	1902	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION		Probable dephospho-CoA kinase (DPCK) that catalyzes the last step in coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaE (encoding DPCK); detected in purified mitochondria in high-throughput studies	coenzyme A biosynthetic process	dephospho-CoA kinase activity	nuclear envelope|mitochondrion|endoplasmic reticulum
YGR274C	YGR274C	TAF1	het	Verified	-0.136458234042199	0.445729520022332	no	588	0.452682000024965	1878	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS	RNA POL II, HOLOENZYME	TFIID subunit (145 kDa), involved in RNA polymerase II transcription initiation; possesses in vitro histone acetyltransferase activity but its role in vivo appears to be minor; involved in promoter binding and G1/S progression	RNA polymerase II transcriptional preinitiation complex assembly|transcription from RNA polymerase II promoter	TBP-class protein binding|chromatin binding|protein complex scaffold|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly|histone acetyltransferase activity	transcription factor TFIID complex
YGL103W	YGL103W	RPL28	het	Verified	-0.143294594494977	0.443028762373271	no	589	0.442343755200841	1879	NA	FT	TRANSLATION	NUCLEUS	RIBOSOME	Ribosomal 60S subunit protein L28; homologous to mammalian ribosomal protein L27A and bacterial L15; may have peptidyl transferase activity; can mutate to cycloheximide resistance	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit|nucleus
YHR007C	YHR007C	ERG11	het	Verified	-0.144199107755441	0.442671622745299	no	590	0.467499762562569	1821	NA	FF|FT	LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	ENDOPLASMIC RETICULUM		Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p	ergosterol biosynthetic process	sterol 14-demethylase activity	endoplasmic reticulum
YIL129C	YIL129C	TAO3	het	Verified	-0.144734465170486	0.442460263193915	no	591	0.458527310323652	1840	NA	FT	CELL DIVISION	MITOCHONDRION|SITE OF POLARIZED GROWTH		Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p	cell morphogenesis|cell budding|budding cell apical bud growth	molecular_function	incipient cellular bud site|mitochondrion|cellular bud|mating projection tip
YDL055C	YDL055C	PSA1	het	Verified	-0.14676663872533	0.441658108958725	no	592	0.433252647655056	1929	NA	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure	protein glycosylation|cell wall mannoprotein biosynthetic process|GDP-mannose biosynthetic process	mannose-1-phosphate guanylyltransferase activity	cytoplasm
YDL139C	YDL139C	SCM3	het	Verified	-0.147975425739725	0.441181081065755	no	593	0.427145824743628	1942	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|PROTEOLYSIS|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Nonhistone component of centromeric chromatin; binds stoichiometrically to CenH3-H4 histones, required for kinetochore assembly; required for G2/M progression and localization of Cse4p; may protect Cse4p from ubiquitylation; homolog of mammalian HJURP	G2/M transition of mitotic cell cycle|chromosome segregation|protein localization to chromosome, centromeric region|Unknown	centromere-specific nucleosome binding	nucleus|condensed nuclear chromosome, centromeric region|cytoplasm
YPR161C	YPR161C	SGV1	het	Verified	-0.152676654580043	0.439326635921953	no	594	0.43832779406354	1931	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|PROTEIN PHOSPHORYLATION	NUCLEUS		Cyclin (Bur2p)-dependent protein kinase that functions in transcriptional regulation; phosphorylates the carboxy-terminal domain of Rpo21p and the C-terminal repeat domain of Spt5p; regulated by Cak1p; similar to metazoan CDK9 proteins	phosphorylation of RNA polymerase II C-terminal domain|protein phosphorylation|transcription, DNA-dependent|positive regulation of histone H3-K4 methylation	RNA polymerase II carboxy-terminal domain kinase activity|cyclin-dependent protein kinase activity	cyclin-dependent protein kinase holoenzyme complex|nucleus
YDL126C	YDL126C	CDC48	het	Verified	-0.156613395394905	0.43777477241514	no	595	0.439326502493536	1898	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|CHROMOSOME SEGREGATION	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION|SITE OF POLARIZED GROWTH	UBIQUITIN LIGASE COMPLEX	AAA ATPase involved in multiple processes; subunit of polyubiquitin-selective segregase complex involved in ERAD, cell wall integrity during heat stress, mitotic spindle disassembly; subunit of complex involved in mitochondria-associated degradation; role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing; roles in macroautophagy, PMN, RAD, ribophagy, and homotypic ER membrane fusion; functional ortholog of human p97/VCP	proteasomal ubiquitin-dependent protein catabolic process|mitotic spindle disassembly|ER-associated protein catabolic process|mitochondria-associated protein catabolic process|macroautophagy|sister chromatid biorientation|ER-associated misfolded protein catabolic process|nucleus-associated proteasomal ubiquitin-dependent protein catabolic process|retrograde protein transport, ER to cytosol|piecemeal microautophagy of nucleus|endoplasmic reticulum membrane fusion|ribophagy|Unknown|cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process	ubiquitin binding|ATPase activity	mitochondrion|Cdc48p-Npl4p-Ufd1p AAA ATPase complex|Cdc48p-Npl4p-Vms1p AAA ATPase complex|cytosol|Doa10p ubiquitin ligase complex|nucleus|endoplasmic reticulum membrane|mating projection tip
YOR194C	YOR194C	TOA1	het	Verified	-0.156770642634808	0.437712805252214	no	596	0.438103629537512	1895	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RNA POL II, HOLOENZYME	TFIIA large subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to largest and second largest subunits of human and Drosophila TFIIA	transcription initiation from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly	TBP-class protein binding|TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly	transcription factor TFIIA complex
YPL063W	YPL063W	TIM50	het	Verified	-0.164495691886361	0.43467046896559	no	597	0.475977110828177	1773	NA	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); acts as receptor for the TIM23 complex guiding incoming precursors from the TOM complex; may control the gating of the Tim23p-Tim17p channel	protein import into mitochondrial matrix	mitochondrion targeting sequence binding|protein channel activity	mitochondrion|mitochondrial inner membrane presequence translocase complex
YPL237W	YPL237W	SUI3	het	Verified	-0.16681476926544	0.433757898664043	no	598	0.443316921789024	1886	NA	FT	TRANSLATION		RIBOSOME	Beta subunit of the translation initiation factor eIF2, involved in the identification of the start codon; proposed to be involved in mRNA binding	translational initiation	translation initiation factor activity	multi-eIF complex|ribosome|eukaryotic translation initiation factor 2 complex
YKR025W	YKR025W	RPC37	het	Verified	-0.177506176991779	0.429555406870243	no	599	0.430445160101726	1923	NA	FT		NUCLEUS		RNA polymerase III subunit C37	tRNA transcription from RNA polymerase III promoter	DNA-directed RNA polymerase activity	DNA-directed RNA polymerase III complex
YBR123C	YBR123C	TFC1	het	Verified	-0.179004808791378	0.428966962906688	no	600	0.450460136097237	1856	NA	FT		NUCLEUS		One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes; human homolog is TFIIIC-63	transcription from a RNA polymerase III hybrid type promoter|transcription from RNA polymerase III type 2 promoter|5S class rRNA transcription from RNA polymerase III type 1 promoter	RNA polymerase III type 1 promoter sequence-specific DNA binding|RNA polymerase III type 2 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity|RNA polymerase III type 2 promoter sequence-specific DNA binding|RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity|DNA binding, bending	transcription factor TFIIIC complex
YLR115W	YLR115W	CFT2	het	Verified	-0.183093126936303	0.427362474264555	no	601	0.412858934312804	1974	NA	FT	RNA PROCESSING	NUCLEUS		Subunit of the mRNA cleavage and polyadenlylation factor (CPF); required for pre-mRNA cleavage, polyadenylation and poly(A) site recognition, 43% similarity with the mammalian CPSF-100 protein.	mRNA cleavage|mRNA polyadenylation	RNA binding	mRNA cleavage factor complex|mRNA cleavage and polyadenylation specificity factor complex
YLR229C	YLR229C	CDC42	het	Verified	-0.188240681293971	0.425343991704876	no	602	0.438104026090585	1905	NA	FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|SIGNALING|CELL DIVISION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins	budding cell apical bud growth|Rho protein signal transduction|budding cell isotropic bud growth|regulation of initiation of mating projection growth|regulation of vacuole fusion, non-autophagic|regulation of exit from mitosis|pheromone-dependent signal transduction involved in conjugation with cellular fusion|pseudohyphal growth|establishment of cell polarity|invasive growth in response to glucose limitation|positive regulation of exocytosis	GTPase activity|signal transducer activity	nuclear membrane|fungal-type vacuole membrane|incipient cellular bud site|plasma membrane|cellular bud neck|mating projection tip|cellular bud tip
YIL115C	YIL115C	NUP159	het	Verified	-0.188683263767405	0.425170534774424	no	603	0.43743953688196	1886	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes directly to nucleocytoplasmic transport; regulates ADP release from the ATP-dependent RNA helicase Dbp5p; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup116p)	poly(A)+ mRNA export from nucleus|NLS-bearing substrate import into nucleus|protein export from nucleus|ribosomal large subunit export from nucleus|ncRNA export from nucleus|nuclear pore distribution|ribosomal small subunit export from nucleus	nucleocytoplasmic transporter activity|adenyl-nucleotide exchange factor activity	nuclear pore central transport channel|integral to membrane|nuclear pore cytoplasmic filaments|nuclear pore
YBR257W	YBR257W	POP4	het	Verified	-0.191570405241972	0.424039363152752	no	604	0.415505089017756	1988	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P	tRNA processing|intronic box C/D snoRNA processing|mRNA cleavage|rRNA processing	ribonuclease MRP activity|ribonuclease P activity	nucleolar ribonuclease P complex|ribonuclease MRP complex
YDL102W	YDL102W	POL3	het	Verified	-0.194814008348961	0.422769277663761	no	605	0.42051747662423	1955	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER)	lagging strand elongation|RNA-dependent DNA replication|base-excision repair|postreplication repair|DNA replication, removal of RNA primer|nucleotide-excision repair|mismatch repair|maintenance of fidelity involved in DNA-dependent DNA replication|DNA replication|leading strand elongation	single-stranded DNA specific 3'-5' exodeoxyribonuclease activity|DNA-directed DNA polymerase activity	delta DNA polymerase complex|replication fork
YOR319W	YOR319W	HSH49	het	Verified	-0.200095906314804	0.420702787456924	no	606	0.41396785340748	2025	NA	FF|FT	RNA PROCESSING	NUCLEUS		U2-snRNP associated splicing factor with similarity to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM)	mRNA splicing, via spliceosome	RNA binding	U2 snRNP|U2-type prespliceosome
YLR071C	YLR071C	RGR1	het	Verified	-0.203505891606968	0.419369820598149	no	607	0.416020575040703	1968	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RNA POL II, HOLOENZYME	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for glucose repression, HO repression, RME1 repression and sporulation	negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II repressing transcription factor binding	core mediator complex
YBR142W	YBR142W	MAK5	het	Verified	-0.207388087692635	0.417853392509818	no	608	0.415031599148226	1988	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Essential nucleolar protein, putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunits	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal large subunit biogenesis|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	ATP-dependent RNA helicase activity	nucleolus
YPR104C	YPR104C	FHL1	het	Verified	-0.209329625141437	0.41709546325675	no	609	0.441668697286963	1921	NA	FT	TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS	NUCLEUS|CHROMOSOME		Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants	negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter|positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter	RNA polymerase II transcription corepressor binding|RNA polymerase II transcription coactivator binding|sequence-specific DNA binding|DNA binding	nuclear chromatin|nucleolus|nucleus|CURI complex
YIL091C	YIL091C	UTP25	het	Verified	-0.212600041078293	0.415819469700168	no	610	0.412216925001452	1976	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Nucleolar protein required for 35S pre-RNA processing and 40S ribosomal subunit biogenesis	ribosomal small subunit biogenesis|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	U3 snoRNA binding|rRNA binding	small-subunit processome|nucleolus|nucleus
YKR002W	YKR002W	PAP1	het	Verified	-0.215759750645847	0.414587511827375	no	611	0.419975140227154	1965	NA	FT	RNA PROCESSING	NUCLEUS		Poly(A) polymerase, one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs; required for gene looping	mRNA polyadenylation|snoRNA polyadenylation	polynucleotide adenylyltransferase activity	nucleoplasm|mRNA cleavage and polyadenylation specificity factor complex
YJR012C_p	YJR012C	YJR012C	het	Uncharacterized	-0.221346106594331	0.412411476150852	no	612	0.399951139801281	2087	NA					Essential protein of unknown function; proposed involvement in transport based on mass spectrometry analysis of copurifying proteins; partially overlaps neighboring ORF, GPI14/YJR013W	biological_process	molecular_function	cellular_component
YLL011W	YLL011W	SOF1	het	Verified	-0.221706372201942	0.412271234630362	no	613	0.415179686812054	1991	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Essential protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	small-subunit processome|nucleolus|90S preribosome
YOR075W	YOR075W	UFE1	het	Verified	-0.224029992289103	0.411366982912496	no	614	0.423647038337386	1959	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		t-SNARE required for retrograde vesicular traffic and homotypic ER membrane fusion; forms a complex with the SNAREs Sec22p, Sec20p and Use1p to mediate fusion of Golgi-derived vesicles at the ER	retrograde vesicle-mediated transport, Golgi to ER|endoplasmic reticulum membrane fusion|vesicle fusion with endoplasmic reticulum	SNAP receptor activity	SNARE complex|integral to membrane|endoplasmic reticulum
YDR498C	YDR498C	SEC20	het	Verified	-0.224187101366796	0.411305859836428	no	615	0.416898935643306	1974	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Membrane glycoprotein v-SNARE involved in retrograde transport from the Golgi to the ER; required for N- and O-glycosylation in the Golgi but not in the ER; interacts with the Dsl1p complex through Tip20p	retrograde vesicle-mediated transport, Golgi to ER|vesicle fusion with endoplasmic reticulum	SNAP receptor activity	SNARE complex|integral to membrane|endoplasmic reticulum|peroxisome
YGL011C	YGL011C	SCL1	het	Verified	-0.232647774478403	0.408017463167594	no	616	0.416445695964955	1973	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION		Alpha 1 subunit of the 20S proteasome involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria	proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process	molecular_function	mitochondrion|proteasome core complex, alpha-subunit complex|nucleus|proteasome storage granule|nuclear outer membrane-endoplasmic reticulum membrane network
YDR023W	YDR023W	SES1	het	Verified	-0.234482340702971	0.407305270583005	no	617	0.382905145758019	2091	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION			Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p	seryl-tRNA aminoacylation	serine-tRNA ligase activity	cytoplasm
YEL034W	YEL034W	HYP2	het	Verified	-0.237003928277732	0.406326871373931	no	618	0.425719871987126	1912	NA	FF|FT	KETONE METABOLISM|PROTEIN COMPLEX ORG/BIOGENESIS|AMINO ACID METABOLISM|TRANSLATION	MITOCHONDRION	RIBOSOME	Translation elongation factor eIF-5A; may function in translation initiation; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has a paralog, ANB1, that arose from the whole genome duplication	positive regulation of translational initiation|translational frameshifting|positive regulation of translational termination|positive regulation of translational elongation	ribosome binding|RNA binding|translation elongation factor activity|translation initiation factor activity	mitochondrion|cytosolic ribosome|cytoplasm
YOR057W	YOR057W	SGT1	het	Verified	-0.244441841311887	0.403444319857988	no	619	0.398079806013836	2046	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|SIGNALING		UBIQUITIN LIGASE COMPLEX	Cochaperone protein; regulates activity of adenylyl cyclase Cyr1p; involved in kinetochore complex assembly; associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex; acts as a linker between Skp1p and HSP90 complexes; protein abundance increases in response to DNA replication stress	regulation of cell cycle|kinetochore assembly|cAMP-mediated signaling|protein complex assembly|protein ubiquitination	protein binding, bridging|chaperone binding	ubiquitin ligase complex
YGR267C	YGR267C	FOL2	het	Verified	-0.254801777986387	0.399438100977834	no	620	0.390693929703594	2056	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM	NUCLEUS		GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway	folic acid-containing compound biosynthetic process	GTP cyclohydrolase I activity	nucleus|cytoplasm
YER021W	YER021W	RPN3	het	Verified	-0.255375891496304	0.39921639470147	no	621	0.424258832740579	1943	NA	FT	PROTEOLYSIS			Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control	ubiquitin-dependent protein catabolic process	molecular_function	proteasome regulatory particle, lid subcomplex
YMR260C	YMR260C	TIF11	het	Verified	-0.25917584662518	0.397749783070756	no	622	0.400115858741531	2026	NA	FT	TRANSLATION		RIBOSOME	Translation initiation factor eIF1A, essential protein that forms a complex with Sui1p (eIF1) and the 40S ribosomal subunit and scans for the start codon; C-terminus associates with Fun12p (eIF5B); N terminus interacts with eIF2 and eIF3	translational initiation	double-stranded RNA binding|translation initiation factor activity	ribosome
YPL210C	YPL210C	SRP72	het	Verified	-0.260372140657864	0.397288365282251	no	623	0.398672202616404	2070	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane	SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition|protein targeting to ER	signal sequence binding	signal recognition particle, endoplasmic reticulum targeting
YDR473C	YDR473C	PRP3	het	Verified	-0.261648307833723	0.39679629837093	no	624	0.407610115149444	1997	NA	FT	RNA PROCESSING	NUCLEUS		Splicing factor, component of the U4/U6-U5 snRNP complex	mRNA splicing, via spliceosome	molecular_function	U4/U6 x U5 tri-snRNP complex
YCL054W	YCL054W	SPB1	het	Verified	-0.264521587626069	0.3956890162602	no	625	0.400034131894234	2039	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA methylation	rRNA (uridine-2'-O-)-methyltransferase activity|rRNA (guanine) methyltransferase activity	nucleolus|nucleus|preribosome, large subunit precursor
YOR046C	YOR046C	DBP5	het	Verified	-0.266308517047339	0.395000807111565	no	626	0.398232807431087	2019	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|SITE OF POLARIZED GROWTH	NUCLEAR PORE	Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family; involved in mRNA export from the nucleus; involved in translation termination; ATP/ADP cycling is regulated by Gle1p and Nup159p	translational termination|mRNA export from nucleus	RNA helicase activity|inositol hexakisphosphate binding|RNA-dependent ATPase activity	nuclear pore cytoplasmic filaments|nucleus|polysome|nuclear pore|cellular bud tip|cytoplasm
YPL146C	YPL146C	NOP53	het	Verified	-0.267239218969046	0.394642490730925	no	627	0.380527330890423	2122	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Nucleolar protein; involved in biogenesis of the 60S subunit of the ribosome; interacts with rRNA processing factors Cbf5p and Nop2p; null mutant is viable but growth is severely impaired	ribosomal large subunit export from nucleus|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	rRNA binding	nucleolus|nucleus
YLR378C	YLR378C	SEC61	het	Verified	-0.268273381322183	0.39424444704429	no	628	0.38384203185085	2089	NA	FT	PROTEIN LOCALIZATION|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER	posttranslational protein targeting to membrane, translocation|retrograde protein transport, ER to cytosol|ER-associated protein catabolic process|SRP-dependent cotranslational protein targeting to membrane, translocation|peptide transport	peptide transporter activity|P-P-bond-hydrolysis-driven protein transmembrane transporter activity|signal sequence binding	integral to membrane|Sec61 translocon complex
YDR054C	YDR054C	CDC34	het	Verified	-0.268724335896023	0.394070911533491	no	629	0.369600862242735	2111	NA	FT	CELL CYCLE|CELL DIVISION|PROTEOLYSIS	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Ubiquitin-conjugating enzyme (E2); catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation; protein abundance increases in response to DNA replication stress	G2/M transition of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|protein autoubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|G1/S transition of mitotic cell cycle|protein polyubiquitination	ubiquitin-protein ligase activity|protein homodimerization activity	SCF ubiquitin ligase complex|nucleus|cytoplasm
YNL317W	YNL317W	PFS2	het	Verified	-0.269200835130976	0.393887568822455	no	630	0.39033376253662	2086	NA	FT	RNA PROCESSING	NUCLEUS		Integral subunit of the pre-mRNA cleavage and polyadenylation factor (CPF) complex; plays an essential role in mRNA 3'-end formation by bridging different processing factors and thereby promoting the assembly of the processing complex	mRNA cleavage|mRNA polyadenylation	RNA binding	mRNA cleavage and polyadenylation specificity factor complex
YIR008C	YIR008C	PRI1	het	Verified	-0.271339399486787	0.393065003134591	no	631	0.389459983132648	2080	NA	FT		NUCLEUS|CHROMOSOME		Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair	lagging strand elongation|DNA replication, synthesis of RNA primer|DNA replication initiation|DNA replication	single-stranded DNA binding|DNA primase activity	alpha DNA polymerase:primase complex|nuclear replication fork
YER093C	YER093C	TSC11	het	Verified	-0.274901160948483	0.391696087595586	no	632	0.391724668480122	2095	NA	FT	LIPID METABOLISM|SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	PLASMA MEMBRANE		Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p), a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; involved in sphingolipid metabolism; contains a RasGEFN domain	fungal-type cell wall organization|TOR signaling cascade|regulation of cell growth|establishment or maintenance of actin cytoskeleton polarity|sphingolipid biosynthetic process	protein binding	TORC2 complex
YBL023C	YBL023C	MCM2	het	Verified	-0.276672222659413	0.391015901331268	no	633	0.427282129662172	1945	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex; relative distribution to the nucleus increases upon DNA replication stress	S phase of mitotic cell cycle|DNA strand elongation involved in DNA replication|pre-replicative complex assembly|double-strand break repair via break-induced replication	chromatin binding|DNA replication origin binding|DNA helicase activity|single-stranded DNA binding	replication fork protection complex|nucleus|DNA replication preinitiation complex|pre-replicative complex|cytoplasm|MCM complex
YBL014C	YBL014C	RRN6	het	Verified	-0.278328970734039	0.390379919472185	no	634	0.38334009039918	2101	NA	FT		NUCLEUS		Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p	transcription initiation from RNA polymerase I promoter|transcription of nuclear large rRNA transcript from RNA polymerase I promoter	RNA polymerase I regulatory region DNA binding|RNA polymerase I transcription factor binding|RNA polymerase I CORE element sequence-specific DNA binding transcription factor recruiting transcription factor activity	RNA polymerase I core factor complex
YLR186W	YLR186W	EMG1	het	Verified	-0.280634909466955	0.389495218841786	no	635	0.383594920418213	2088	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS|CYTOSKELETON		Methyltransferase for rRNA; catalyzes methylation of the pseudouridine residue 1191 of 18S rRNA; member of the SPOUT methyltransferase family; required for maturation of 18S rRNA and for 40S ribosomal subunit production independently of methyltransferase activity; forms homodimers; human ortholog is mutated in Bowen-Conradi syndrome, and the equivalent mutation in yeast affects Emg1p dimerization and localization but not its methyltransferase activity	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal small subunit biogenesis|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA base methylation|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA processing	rRNA (pseudouridine) methyltransferase activity	small-subunit processome|nucleolus|nucleus|nuclear microtubule|cytoplasm|90S preribosome
YPL242C	YPL242C	IQG1	het	Verified	-0.282577595332102	0.38875032847978	no	636	0.392902204787038	2054	NA	FT	CELL CYCLE|SIGNALING|CELL DIVISION|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Essential protein required for determination of budding pattern; promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family; relocalizes from bud neck to cytoplasm upon DNA replication stress	actin filament organization|response to osmotic stress|cytokinesis	cytoskeletal protein binding	cellular bud neck contractile ring
YAL001C	YAL001C	TFC3	het	Verified	-0.294280747277493	0.384271691547804	no	637	0.426906784910426	1957	NA	FF|FT	PROTEIN LOCALIZATION	NUCLEUS|MITOCHONDRION|CHROMOSOME		Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding	protein localization to chromatin|transcription from a RNA polymerase III hybrid type promoter|transcription from RNA polymerase III type 2 promoter|5S class rRNA transcription from RNA polymerase III type 1 promoter	RNA polymerase III type 1 promoter sequence-specific DNA binding|RNA polymerase III type 2 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity|RNA polymerase III type 2 promoter sequence-specific DNA binding|RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity|DNA binding, bending	transcription factor TFIIIC complex|mitochondrion|nuclear condensin complex
YDR160W	YDR160W	SSY1	het	Verified	-0.294827377990537	0.384062875466938	no	638	0.385875565296555	2091	NA	FT		PLASMA MEMBRANE		Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes	response to amino acid stimulus	molecular_function	integral to membrane|plasma membrane
YLR316C	YLR316C	TAD3	het	Verified	-0.297090591597527	0.383198673547999	no	639	0.370015428036395	2128	NA	FT	RNA PROCESSING	NUCLEUS		Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad2p that converts adenosine to inosine at the wobble position of several tRNAs	tRNA modification	tRNA-specific adenosine deaminase activity	nucleus|cytoplasm
YLR007W	YLR007W	NSE1	het	Verified	-0.297286227834356	0.383123997605138	no	640	0.374928228605466	2130	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair	DNA repair|postreplication repair	molecular_function	Smc5-Smc6 complex|nucleus
YJL025W	YJL025W	RRN7	het	Verified	-0.297595850971271	0.383005820812283	no	641	0.396474474274999	2032	NA	FT		NUCLEUS		Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p	transcription initiation from RNA polymerase I promoter|transcription of nuclear large rRNA transcript from RNA polymerase I promoter	TBP-class protein binding|RNA polymerase I CORE element sequence-specific DNA binding|RNA polymerase I CORE element sequence-specific DNA binding transcription factor recruiting transcription factor activity	nucleolus|RNA polymerase I core factor complex
YGR158C	YGR158C	MTR3	het	Verified	-0.299039185087608	0.382455073672827	no	642	0.384637662588994	2083	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6)	nuclear mRNA surveillance|nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear polyadenylation-dependent mRNA catabolic process|nonfunctional rRNA decay|U4 snRNA 3'-end processing|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|polyadenylation-dependent snoRNA 3'-end processing|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|nuclear-transcribed mRNA catabolic process, non-stop decay	molecular_function	nucleolus|nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)
YLR145W	YLR145W	RMP1	het	Verified	-0.300229094980056	0.382001206780309	no	643	0.381736592105715	2090	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Subunit of RNase MRP, which processes pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; unlike most subunits, not shared between RNase MRP and nuclear RNase P	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|mRNA cleavage	ribonuclease MRP activity	nucleolus|nucleus|ribonuclease MRP complex|cytoplasm
YDR527W	YDR527W	RBA50	het	Verified	-0.301496805709552	0.381517842715974	no	644	0.379244606704879	2110	NA	FF|FT	TRANSCRIPTION FROM RNA POL II			Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1	transcription from RNA polymerase II promoter	molecular_function	cytoplasm
YOL127W	YOL127W	RPL25	het	Verified	-0.302098192435671	0.381288605169547	no	645	0.400538222066077	2077	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L25; primary rRNA-binding ribosomal protein component of large ribosomal subunit; binds to 25S rRNA via a conserved C-terminal motif; homologous to mammalian ribosomal protein L23A and bacterial L23	cytoplasmic translation|ribosomal large subunit assembly	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YCR054C	YCR054C	CTR86	het	Verified	-0.303112480235918	0.380902071722093	no	646	0.372086704487421	2134	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Essential protein of unknown function; with orthologs in Ashbya gossypii and Candida albicans; similar to human ATXN10, mutations in which cause spinocerebellar ataxia type 10; codon usage corresponds to that observed for yeast genes expressed at low levels; relative distribution to the nucleus increases upon DNA replication stress	biological_process	molecular_function	cytoplasm
YGR083C	YGR083C	GCD2	het	Verified	-0.304632538276298	0.380323017612902	no	647	0.39855736125838	2019	NA	FT	TRANSLATION			Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression	regulation of translational initiation	enzyme regulator activity|guanyl-nucleotide exchange factor activity|translation initiation factor activity	eukaryotic translation initiation factor 2B complex|guanyl-nucleotide exchange factor complex
YAL041W	YAL041W	CDC24	het	Verified	-0.305791276550019	0.379881785416687	no	648	0.382653122775544	2086	NA	FT	CELL CYCLE|SIGNALING	NUCLEUS|SITE OF POLARIZED GROWTH		Guanine nucleotide exchange factor for Cdc42p; also known as a GEF or GDP-release factor; required for polarity establishment and maintenance, and mutants have morphological defects in bud formation and shmooing; relocalizes from nucleus to cytoplasm upon DNA replication stress	regulation of exit from mitosis|establishment of cell polarity|small GTPase mediated signal transduction	Rho guanyl-nucleotide exchange factor activity	incipient cellular bud site|nucleus|cellular bud neck|mating projection tip|cellular bud tip|cytoplasm
YDL084W	YDL084W	SUB2	het	Verified	-0.307348806943148	0.379288944825982	no	649	0.386799214509879	2105	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Component of the TREX complex required for nuclear mRNA export; member of the DEAD-box RNA helicase superfamily and is involved in early and late steps of spliceosome assembly; homolog of the human splicing factor hUAP56; relocalizes from nucleus to cytoplasm upon DNA replication stress	mRNA 3'-end processing|mRNA export from nucleus|transcription-coupled nucleotide-excision repair|mRNA splicing, via spliceosome|transcription elongation from RNA polymerase II promoter|chromatin silencing at telomere	ATP-dependent RNA helicase activity	chromosome, telomeric region|nucleus|transcription export complex|spliceosomal complex
YHR196W	YHR196W	UTP9	het	Verified	-0.312125085078517	0.377472731524521	no	650	0.362999740574757	2122	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS|CHROMOSOME		Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA	positive regulation of transcription from RNA polymerase I promoter|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	snoRNA binding	small-subunit processome|rDNA heterochromatin|nucleolus|t-UTP complex|nucleus|90S preribosome
YNR016C	YNR016C	ACC1	het	Verified	-0.313543939165753	0.376933721850344	no	651	0.401323206587928	2025	NA	FF|FT	PROTEIN LOCALIZATION|KETONE METABOLISM|LIPID METABOLISM|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids;	nuclear envelope organization|protein import into nucleus|fatty acid biosynthetic process	biotin carboxylase activity|acetyl-CoA carboxylase activity	mitochondrion|endoplasmic reticulum membrane
YCR093W	YCR093W	CDC39	het	Verified	-0.318870892886978	0.374912208573289	no	652	0.390685367779123	2074	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RNA PROCESSING	NUCLEUS		Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor	response to pheromone involved in conjugation with cellular fusion|regulation of cell cycle|regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|pseudohyphal growth|negative regulation of transcription from RNA polymerase II promoter|nuclear-transcribed mRNA poly(A) tail shortening|transcription elongation from RNA polymerase II promoter	molecular_function	CCR4-NOT core complex|nucleus|cytoplasm
YPL175W	YPL175W	SPT14	het	Verified	-0.32196397809585	0.373739991975043	no	653	0.385469480467139	2060	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis, mutations cause defects in transcription and in biogenesis of cell wall proteins	GPI anchor biosynthetic process	UDP-glycosyltransferase activity	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|endoplasmic reticulum
YLR105C	YLR105C	SEN2	het	Verified	-0.326346654854178	0.372081046597519	no	654	0.35884395179074	2157	NA	FT	RNA PROCESSING	ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION		Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease	tRNA-type intron splice site recognition and cleavage	tRNA-intron endonuclease activity	mitochondrial outer membrane|mitochondrion|tRNA-intron endonuclease complex
YKL012W	YKL012W	PRP40	het	Verified	-0.329532855138979	0.370876482301631	no	655	0.357375394655316	2204	NA	FT	RNA PROCESSING	NUCLEUS		U1 snRNP protein involved in splicing, interacts with the branchpoint-binding protein during the formation of the second commitment complex	mRNA splicing, via spliceosome	RNA binding	U1 snRNP|nucleus|U2-type prespliceosome
YDL145C	YDL145C	COP1	het	Verified	-0.329851296547122	0.370756162702705	no	656	0.370067672984044	2136	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway	retrograde vesicle-mediated transport, Golgi to ER|ER to Golgi vesicle-mediated transport	ubiquitin binding	COPI vesicle coat
YKL111C_d	YKL111C	YKL111C	het	Dubious	-0.333966189935188	0.369202535919658	no	657	0.360388250624855	2151	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species; partially overlaps the verified essential gene ABF1	Unknown	Unknown	Unknown
YDL150W	YDL150W	RPC53	het	Verified	-0.336191733573104	0.368363143076529	no	658	0.423905835756154	1954	NA	FF|FT		NUCLEUS		RNA polymerase III subunit C53	tRNA transcription from RNA polymerase III promoter	DNA-directed RNA polymerase activity	DNA-directed RNA polymerase III complex
YPL209C	YPL209C	IPL1	het	Verified	-0.336540817957183	0.368231538208709	no	659	0.365838071987417	2165	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME|CYTOSKELETON	KINETOCHORE	Aurora kinase subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), involved in regulating kinetochore-microtubule attachments; helps maintain condensed chromosomes during anaphase and early telophase; required for SPB cohesion and prevention of multipolar spindle formation; localizes to nuclear foci that become diffuse upon DNA replication stress; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon SAC arrest	spindle checkpoint|attachment of spindle microtubules to kinetochore|chromosome segregation|mitotic spindle disassembly|protein phosphorylation|meiotic sister chromatid segregation|homologous chromosome segregation|regulation of cytokinesis|mitotic cell cycle G2/M transition decatenation checkpoint	protein kinase activity	spindle microtubule|spindle midzone|chromosome passenger complex|condensed nuclear chromosome kinetochore|kinetochore microtubule|spindle
YJR057W	YJR057W	CDC8	het	Verified	-0.336641994748274	0.3681933974317	no	660	0.353229590673332	2187	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		Thymidylate and uridylate kinase, functions in de novo biosynthesis of pyrimidine deoxyribonucleotides; converts dTMP to dTDP and dUMP to dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe Tmp1p	dTDP biosynthetic process|dTTP biosynthetic process|dUDP biosynthetic process	uridylate kinase activity|thymidylate kinase activity	nucleus|cytoplasm
YNL103W	YNL103W	MET4	het	Verified	-0.340227867381986	0.366842466751036	no	661	0.368323228012475	2155	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p	response to cadmium ion|sulfur amino acid metabolic process|response to arsenic-containing substance|positive regulation of transcription from RNA polymerase II promoter	transcription coactivator activity	nucleus
YNR046W	YNR046W	TRM112	het	Verified	-0.342970731727896	0.365810239440179	no	662	0.337064685923274	2237	NA	FT	RNA PROCESSING	NUCLEUS		Protein involved in methylation of tRNA, rRNA, and translation factors; subunit of tRNA methyltransferase (MTase) complexes in combination with Trm9p and Trm11p; interacts with and stabilizes 18S rRNA methyltransferase Bud23p; subunit of complex with Mtq2p that methylates Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; deletion confers resistance to zymocin; relative distribution to the nucleus increases upon DNA replication stress	rRNA (guanine-N7)-methylation|peptidyl-glutamine methylation|tRNA methylation	protein methyltransferase activity|zinc ion binding|tRNA (guanine-N2-)-methyltransferase activity|rRNA (guanine) methyltransferase activity	eRF1 methyltransferase complex|nucleolus|nucleus|tRNA (m2G10) methyltransferase complex|cytoplasm
YGL137W	YGL137W	SEC27	het	Verified	-0.345650613180861	0.364802651956985	no	663	0.394363261446274	2058	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Essential beta'-coat protein of the COPI coatomer, involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP	retrograde vesicle-mediated transport, Golgi to ER|late endosome to vacuole transport via multivesicular body sorting pathway|ER to Golgi vesicle-mediated transport	ubiquitin binding	COPI vesicle coat
YPR112C	YPR112C	MRD1	het	Verified	-0.346030378196455	0.364659942425131	no	664	0.364614106565701	2156	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Essential conserved small ribosomal subunit (40s) synthesis factor; component of the 90S preribosome; required for production of 18S rRNA and small ribosomal subunit; contains five consensus RNA-binding domains and binds to the pre-rRNA at two sites within the 18S region	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|small-subunit processome assembly|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	nucleolus|90S preribosome
YCR013C_d	YCR013C	YCR013C	het	Dubious	-0.349849107435448	0.363225971297607	no	665	0.335994279294902	2230	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YCR013C and the overlapping essential gene PGK1 is reduced in a gcr1 null mutant	Unknown	Unknown	Unknown
YDR177W	YDR177W	UBC1	het	Verified	-0.354000815363747	0.36166913609105	no	666	0.36857510387161	2135	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEOLYSIS			Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived and abnormal proteins; plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD); component of the cellular stress response; protein abundance increases in response to DNA replication stress	spore germination|vesicle organization|endocytosis|ER-associated protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein polyubiquitination|protein monoubiquitination	ubiquitin-protein ligase activity	proteasome complex
YJL031C	YJL031C	BET4	het	Verified	-0.354110059895424	0.361628201615976	no	667	0.398976999013357	2029	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN PRENYLATION			Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p	protein targeting to membrane|protein geranylgeranylation|ER to Golgi vesicle-mediated transport	Rab geranylgeranyltransferase activity	Rab-protein geranylgeranyltransferase complex
YJL087C	YJL087C	TRL1	het	Verified	-0.358137924835596	0.360120049448032	no	668	0.333903507188177	2270	NA	FT	RNA PROCESSING|SIGNALING|TRANSLATION	ENDOMEMBRANE SYSTEM|NUCLEUS		tRNA ligase, required for tRNA splicing and for both splicing and translation of HAC1 mRNA in the UPR; has phosphodiesterase, polynucleotide kinase, and ligase activities; localized at the inner nuclear envelope and partially to polysomes	UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response|tRNA splicing, via endonucleolytic cleavage and ligation|positive regulation of translation in response to stress	GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity|RNA ligase (ATP) activity|2',3'-cyclic-nucleotide 3'-phosphodiesterase activity	nuclear inner membrane|polysome
YBR087W	YBR087W	RFC5	het	Verified	-0.358920228615393	0.359827383155832	no	669	0.338784971539685	2230	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon	mismatch repair|sister chromatid cohesion|leading strand elongation	DNA clamp loader activity	Elg1 RFC-like complex|Rad17 RFC-like complex|DNA replication factor C complex|Ctf18 RFC-like complex
YHR197W	YHR197W	RIX1	het	Verified	-0.371344840331918	0.355190351975306	no	670	0.353843358784757	2183	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and possibly pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; RIX1 is an essential gene	ribosomal large subunit assembly|ribosomal subunit export from nucleus|rRNA processing	molecular_function	nucleoplasm|nucleus
YDR180W	YDR180W	SCC2	het	Verified	-0.375588330242634	0.353611483873855	no	671	0.342579478772617	2218	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during DSB repair via histone H2AX; evolutionarily-conserved adherin	double-strand break repair|establishment of protein localization to chromatin|protein localization to chromatin|2-micrometer plasmid partitioning|mitotic chromosome condensation|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery|establishment of mitotic sister chromatid cohesion|rDNA condensation|tRNA gene clustering	molecular_function	nuclear chromatin|2-micrometer circle DNA|SMC loading complex
YBR236C	YBR236C	ABD1	het	Verified	-0.38168356933031	0.351348044420275	no	672	0.33946443590067	2212	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS	RNA POL II, HOLOENZYME	Methyltransferase, catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA	7-methylguanosine mRNA capping|transcription from RNA polymerase II promoter	mRNA (guanine-N7-)-methyltransferase activity	nucleus|DNA-directed RNA polymerase II, holoenzyme
YBR196C	YBR196C	PGI1	het	Verified	-0.385917635983022	0.349778834443197	no	673	0.388398452960475	2052	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		Glycolytic enzyme phosphoglucose isomerase, catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate; required for cell cycle progression and completion of the gluconeogenic events of sporulation	gluconeogenesis|pentose-phosphate shunt|glycolysis	glucose-6-phosphate isomerase activity	cytosol|mitochondrion|plasma membrane
YDR047W	YDR047W	HEM12	het	Verified	-0.387196933968374	0.349305209902761	no	674	0.365137054551073	2164	NA	FF|FT	COFACTOR METABOLISM	NUCLEUS		Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda	heme biosynthetic process	uroporphyrinogen decarboxylase activity	nucleus|cytoplasm
YIL046W	YIL046W	MET30	het	Verified	-0.388750090318785	0.348730512208859	no	675	0.348622902676182	2211	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CELL CYCLE|AMINO ACID METABOLISM|PROTEOLYSIS	NUCLEUS	UBIQUITIN LIGASE COMPLEX	F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus	response to cadmium ion|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|regulation of DNA-dependent DNA replication initiation|M phase of mitotic cell cycle|response to arsenic-containing substance|G1/S transition of mitotic cell cycle|protein polyubiquitination|regulation of transcription involved in G1 phase of mitotic cell cycle|protein ubiquitination	ubiquitin binding	nuclear SCF ubiquitin ligase complex|SCF ubiquitin ligase complex|nucleus
YGR103W	YGR103W	NOP7	het	Verified	-0.389377495787892	0.34849845843048	no	676	0.31726905229851	2306	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Component of several different pre-ribosomal particles; forms a complex with Ytm1p and Erb1p that is required for maturation of the large ribosomal subunit; required for exit from G<sub>0</sub> and the initiation of cell proliferation	ribosomal large subunit biogenesis|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|cell cycle	molecular_function	PeBoW complex|nucleolus|nucleus|preribosome, large subunit precursor
YDL111C	YDL111C	RRP42	het	Verified	-0.391159116753787	0.34783981285827	no	677	0.356857412585352	2180	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7)	nuclear polyadenylation-dependent tRNA catabolic process|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nonfunctional rRNA decay|nuclear polyadenylation-dependent mRNA catabolic process|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|rRNA catabolic process|polyadenylation-dependent snoRNA 3'-end processing|nuclear-transcribed mRNA catabolic process, non-stop decay|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ncRNA 3'-end processing	molecular_function	nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)
YER094C	YER094C	PUP3	het	Verified	-0.392550065979921	0.347325913174971	no	678	0.379442981878196	2087	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10	proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process	endopeptidase activator activity	proteasome storage granule|nucleus|endoplasmic reticulum membrane|proteasome core complex, beta-subunit complex
YML031W	YML031W	NDC1	het	Verified	-0.393711990796445	0.346896843786718	no	679	0.356387733501935	2184	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CYTOSKELETON ORGANIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON	NUCLEAR PORE	Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NDC1	nucleocytoplasmic transport|nuclear pore organization|spindle pole body duplication associated with nuclear envelope	structural constituent of nuclear pore	integral to membrane|nuclear pore transmembrane ring|spindle pole body|nuclear pore
YOR341W	YOR341W	RPA190	het	Verified	-0.397263706270243	0.345586504078232	no	680	0.343337549177378	2227	NA	FT		NUCLEUS		RNA polymerase I largest subunit A190	transcription of nuclear large rRNA transcript from RNA polymerase I promoter	DNA-directed RNA polymerase activity	DNA-directed RNA polymerase I complex|nucleolus
YFL039C	YFL039C	ACT1	het	Verified	-0.400059565900422	0.344556322308512	no	681	0.357617342586317	2154	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|TRANSCRIPTION FROM RNA POL II|CELL CYCLE|MEMBRANE ORGANIZATION|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|RESPON	NUCLEUS|SITE OF POLARIZED GROWTH|CHROMOSOME|CYTOSKELETON	HISTONE ACETYLTRANSFERASE	Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions	ascospore wall assembly|vacuole inheritance|protein secretion|DNA repair|budding cell isotropic bud growth|mitochondrion inheritance|fungal-type cell wall organization|vesicle transport along actin filament|establishment of cell polarity|chronological cell aging|cytokinesis|actin filament reorganization involved in cell cycle|histone acetylation|endocytosis|exocytosis|establishment of mitotic spindle orientation|regulation of transcription from RNA polymerase II promoter|actomyosin contractile ring contraction|cellular response to oxidative stress	structural constituent of cytoskeleton	cellular bud neck contractile ring|actin filament|histone acetyltransferase complex|Swr1 complex|actin filament bundle|NuA4 histone acetyltransferase complex|Ino80 complex|actin cortical patch
YPL204W	YPL204W	HRR25	het	Verified	-0.401287997391485	0.344104049707132	no	682	0.355210728314402	2171	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|RESPONSE TO DNA DAMAGE|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|CHROMOSOME SEGREGATION	NUCLEUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CHROMOSOME|CYTOSKELETON	KINETOCHORE	Protein kinase involved in regulating diverse events including vesicular trafficking, DNA repair, and chromosome segregation; binds the CTD of RNA pol II; homolog of mammalian casein kinase 1delta (CK1delta)	ribosomal small subunit biogenesis|DNA repair|mitosis|ER to Golgi vesicle-mediated transport|protein phosphorylation|attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation|tRNA wobble uridine modification	protein serine/threonine kinase activity|protein kinase activity	chromosome, centromeric region|plasma membrane|nucleus|spindle pole body|monopolin complex|cellular bud neck|cellular bud tip
YIL062C	YIL062C	ARC15	het	Verified	-0.409652138036712	0.341030572257992	no	683	0.333265976633718	2274	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION	MITOCHONDRION|CYTOSKELETON		Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; has mRNA binding activity	mitochondrion inheritance|actin cortical patch assembly	mRNA binding|structural molecule activity	Arp2/3 protein complex|extrinsic to mitochondrial outer membrane
YMR033W	YMR033W	ARP9	het	Verified	-0.414001502957163	0.339436503067319	no	684	0.399039785205421	2050	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS	RSC COMPLEX	Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation	nucleosome positioning|ATP-dependent chromatin remodeling|nucleosome mobilization|chromatin organization|nucleosome disassembly|transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	DNA translocase activity	RSC complex|SWI/SNF complex|nucleus
YDL031W	YDL031W	DBP10	het	Verified	-0.420671374810358	0.336997533280258	no	685	0.331580298659296	2255	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Putative ATP-dependent RNA helicase of the DEAD-box protein family, constituent of 66S pre-ribosomal particles; essential protein involved in ribosome biogenesis	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	ATP-dependent RNA helicase activity	nucleolus|preribosome, large subunit precursor
YNL112W	YNL112W	DBP2	het	Verified	-0.423390155810629	0.336005313011855	no	686	0.356244930109113	2174	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS|MITOCHONDRION		ATP-dependent RNA helicase of the DEAD-box protein family; has a strong preference for dsRNA; involved mRNA decay and rRNA processing; may be involved in suppression of transcription from cryptic initiation sites	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|rRNA processing	RNA helicase activity	mitochondrion|nucleus|cytoplasm
YMR211W	YMR211W	DML1	het	Verified	-0.426968573704164	0.334701108797754	no	687	0.369410203913786	2123	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family	plasmid maintenance|mitochondrial genome maintenance	molecular_function	mitochondrion|cytoplasm
YDR141C	YDR141C	DOP1	het	Verified	-0.430094798026111	0.333563341966858	no	688	0.335083870791145	2274	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|MITOCHONDRION|GOLGI APPARATUS		Golgi-localized, leucine-zipper domain containing protein; involved in endosome to Golgi transport, organization of the ER, establishing cell polarity, and morphogenesis; detected in highly purified mitochondria in high-throughput studies	endoplasmic reticulum organization|cell morphogenesis|Golgi to endosome transport	molecular_function	trans-Golgi network|endosome|mitochondrion|cytoplasm
YGL123W	YGL123W	RPS2	het	Verified	-0.433337581725285	0.332384769651932	no	689	0.330566464606234	2265	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION	NUCLEUS	RIBOSOME	Protein component of the small (40S) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p; homologous to mammalian ribosomal protein S2 and bacterial S5	positive regulation of translational fidelity|rRNA export from nucleus	structural constituent of ribosome|SSU rRNA binding	small-subunit processome|cytosolic small ribosomal subunit
YBL105C	YBL105C	PKC1	het	Verified	-0.433742354852132	0.332237773010558	no	690	0.377997190852744	2124	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION	NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC)	intracellular protein kinase cascade|regulation of nuclear-transcribed mRNA poly(A) tail shortening|fungal-type cell wall organization|signal transduction|actin filament organization|peroxisome degradation|protein phosphorylation|cytoplasmic mRNA processing body assembly	protein kinase C activity	site of polarized growth|cytoskeleton|nucleus|plasma membrane|cytoplasm
YOR336W	YOR336W	KRE5	het	Verified	-0.43453242320075	0.331950927646785	no	691	0.33037834980042	2288	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOPLASMIC RETICULUM		Protein required for beta-1,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defects	(1->6)-beta-D-glucan biosynthetic process	UDP-glucose:glycoprotein glucosyltransferase activity	endoplasmic reticulum
YMR168C	YMR168C	CEP3	het	Verified	-0.43591768145815	0.3314482280103	no	692	0.325635524990214	2268	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CYTOSKELETON ORGANIZATION	NUCLEUS|CHROMOSOME	KINETOCHORE	Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain	septin ring assembly|mitotic cell cycle spindle assembly checkpoint	sequence-specific DNA binding|DNA binding, bending|centromeric DNA binding	condensed nuclear chromosome kinetochore|CBF3 complex
YDL017W	YDL017W	CDC7	het	Verified	-0.439807427851915	0.330038293706922	no	693	0.308102030180119	2329	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION|PROTEIN PHOSPHORYLATION|GENE SILENCING	NUCLEUS		DDK (Dbf4-dependent kinase) catalytic subunit required for origin firing and replication fork progression in mitotic S phase through phosphorylation of Mcm2-7p complexes and Cdc45p; kinase activity correlates with cyclical DBF4 expression; required for pre-meiotic DNA replication, meiotic DSB formation, recruitment of the monopolin complex to kinetochores during meiosis I and as a gene-specific regulator of the meiosis-specific transcription factor Ndt80p	negative regulation of exit from mitosis|regulation of chromatin silencing at telomere|protein phosphorylation|double-strand break repair via break-induced replication|DNA replication initiation	protein serine/threonine kinase activity	nucleus|Dbf4-dependent protein kinase complex
YOR287C	YOR287C	RRP36	het	Verified	-0.442689590331336	0.328995136450341	no	694	0.307699566791427	2345	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Component of 90S preribosomes; involved in early cleavages of the 35S pre-rRNA and in production of the 40S ribosomal subunit	ribosomal small subunit biogenesis|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|cleavage involved in rRNA processing	molecular_function	nucleolus|90S preribosome
YLR033W	YLR033W	RSC58	het	Verified	-0.445325608184279	0.328042232102978	no	695	0.405078616122662	2009	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION	NUCLEUS	RSC COMPLEX	Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance	nucleosome disassembly|transcription elongation from RNA polymerase II promoter|G1/S transition of mitotic cell cycle|chromatin remodeling	molecular_function	RSC complex
YMR240C	YMR240C	CUS1	het	Verified	-0.446607355945727	0.3275792917472	no	696	0.319196040866131	2311	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING	NUCLEUS		Protein required for assembly of U2 snRNP into the spliceosome, forms a complex with Hsh49p and Hsh155p	spliceosomal complex assembly|mRNA splicing, via spliceosome	molecular_function	U2 snRNP|U2-type prespliceosome
YNL189W	YNL189W	SRP1	het	Verified	-0.448139231249929	0.327026358154079	no	697	0.330843658400199	2273	NA	FT	PROTEIN LOCALIZATION	NUCLEUS		Karyopherin alpha homolog, forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during import; may also play a role in regulation of protein degradation	protein targeting to membrane|protein import into nucleus	protein transporter activity	integral to membrane|nuclear exosome (RNase complex)|nucleus|cytoplasm
YKL172W	YKL172W	EBP2	het	Verified	-0.448706768592496	0.326821600641872	no	698	0.345977888790792	2215	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering	nuclear division|rRNA processing	molecular_function	nuclear periphery|nucleolus|preribosome, large subunit precursor
YJL061W	YJL061W	NUP82	het	Verified	-0.453822623517325	0.324978249456298	no	699	0.324604793231789	2269	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup159p, and Nup116p)	mRNA export from nucleus|protein export from nucleus|ribosomal large subunit export from nucleus|protein import into nucleus|ribosomal small subunit export from nucleus	structural constituent of nuclear pore	integral to membrane|nuclear pore cytoplasmic filaments|nuclear pore linkers|nuclear pore
YLR277C	YLR277C	YSH1	het	Verified	-0.458732221857032	0.323213236091921	no	700	0.317101474779142	2338	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		Putative endoribonuclease; subunit of the mRNA cleavage and polyadenylation specificity complex; required for 3' processing, splicing, and transcriptional termination of mRNAs and snoRNAs; protein abundance increases in response to DNA replication stress; YSH1 has a paralog, SYC1, that arose from the whole genome duplication	termination of RNA polymerase II transcription|mRNA cleavage|mRNA polyadenylation|RNA splicing|snoRNA splicing|snoRNA 3'-end processing	endoribonuclease activity|RNA binding	mRNA cleavage factor complex|mRNA cleavage and polyadenylation specificity factor complex
YER112W	YER112W	LSM4	het	Verified	-0.460103001617637	0.322721144845614	no	701	0.339949251214636	2244	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; forms cytoplasmic foci upon DNA replication stress	nuclear-transcribed mRNA catabolic process|mRNA splicing, via spliceosome|cytoplasmic mRNA processing body assembly	U6 snRNA binding	U6 snRNP|nucleolus|small nucleolar ribonucleoprotein complex|cytoplasmic mRNA processing body|U4/U6 x U5 tri-snRNP complex
YOR244W	YOR244W	ESA1	het	Verified	-0.46356133014989	0.321481032484627	no	702	0.317488249791771	2298	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS	HISTONE ACETYLTRANSFERASE	Catalytic subunit of the histone acetyltransferase complex (NuA4); acetylates four conserved internal lysines of histone H4 N-terminal tail and can acetylate histone H2A; required for cell cycle progression and transcriptional silencing at the rDNA locus and regulation of autophagy	DNA repair|histone acetylation|regulation of cell cycle|regulation of transcription by chromatin organization|DNA-dependent transcription, elongation|chromatin silencing at rDNA|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter	H4 histone acetyltransferase activity|histone acetyltransferase activity	Piccolo NuA4 histone acetyltransferase complex|NuA4 histone acetyltransferase complex
YDR145W	YDR145W	TAF12	het	Verified	-0.463712880448069	0.32142673383519	no	703	0.353719227287519	2204	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS	RNA POL II, HOLOENZYME|HISTONE ACETYLTRANSFERASE	Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A	histone acetylation|RNA polymerase II transcriptional preinitiation complex assembly|chromatin modification|transcription from RNA polymerase II promoter	TBP-class protein binding|chromatin binding|RNA polymerase II activating transcription factor binding|protein complex scaffold|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly	SLIK (SAGA-like) complex|SAGA complex|transcription factor TFIID complex
YLR336C	YLR336C	SGD1	het	Verified	-0.468290324412623	0.319788493347389	no	704	0.307914124994021	2353	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS	NUCLEUS		Essential nuclear protein, required for biogenesis of the small ribosomal subunit; has a possible role in the osmoregulatory glycerol response; putative homolog of human NOM1 which is implicated in acute myeloid leukemia	ribosomal small subunit biogenesis|hyperosmotic response	molecular_function	nucleolus|nucleus|FAl1-SGD1 complex
YOR294W	YOR294W	RRS1	het	Verified	-0.474953055148627	0.317410217145485	no	705	0.317595483297731	2290	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Essential protein that binds ribosomal protein L11; required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; localizes to the nucleolus and in foci along nuclear periphery; cooperates with Ebp2p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering; mouse homolog shows altered expression in Huntington's disease model mice	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal large subunit biogenesis|ribosomal large subunit export from nucleus	molecular_function	nucleoplasm|nuclear periphery|nucleolus|preribosome, large subunit precursor
YOR063W	YOR063W	RPL3	het	Verified	-0.475052283413852	0.317374853985355	no	706	0.317237544714453	2325	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L3; homologous to mammalian ribosomal protein L3 and bacterial L3; involved in the replication and maintenance of killer double stranded RNA virus	cytoplasmic translation|ribosomal large subunit assembly	structural constituent of ribosome	cytosolic large ribosomal subunit
YJR002W	YJR002W	MPP10	het	Verified	-0.475396878444163	0.317252059493	no	707	0.344181629563893	2236	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Component of the SSU processome and 90S preribosome, required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and Imp4p, essential for viability; similar to human Mpp10p	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	small-subunit processome|Mpp10 complex|nucleolus|nucleus|90S preribosome
YIL118W	YIL118W	RHO3	het	Verified	-0.481633333830813	0.315033221043794	no	708	0.328540671335117	2275	NA	FT	VESICLE-MEDIATED TRANSPORT|SIGNALING|CYTOSKELETON ORGANIZATION	PLASMA MEMBRANE		Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p	positive regulation of formin-nucleated actin cable assembly|establishment or maintenance of actin cytoskeleton polarity|positive regulation of exocytosis	GTP binding|GTPase activity	cytosol|plasma membrane|cellular bud
YMR290W-A_d	YMR290W-A	YMR290W-A	het	Dubious	-0.486403747602261	0.313340467002946	no	709	0.365314946371385	2166	NA	FF				Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase	Unknown	Unknown	Unknown
YOL005C	YOL005C	RPB11	het	Verified	-0.486771697832289	0.313210064565541	no	710	0.32669975934331	2271	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RNA POL II, HOLOENZYME	RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit	termination of RNA polymerase II transcription|transcription from RNA polymerase II promoter	RNA-directed RNA polymerase activity|DNA-directed RNA polymerase activity	DNA-directed RNA polymerase II, core complex
YHR058C	YHR058C	MED6	het	Verified	-0.487373319164269	0.312996898849719	no	711	0.325070616780354	2300	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RNA POL II, HOLOENZYME	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; protein abundance increases in response to DNA replication stress	RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly	core mediator complex
YBR121C	YBR121C	GRS1	het	Verified	-0.489620084379137	0.312201380772955	no	712	0.288184696581228	2394	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Cytoplasmic and mitochondrial glycyl-tRNA synthase; ligates glycine to the cognate anticodon-bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation; GRS1 has a paralog, GRS2, that arose from the whole genome duplication	mitochondrial glycyl-tRNA aminoacylation|glycyl-tRNA aminoacylation|DNA-dependent transcription, termination	glycine-tRNA ligase activity	mitochondrion|cytoplasm
YLR166C	YLR166C	SEC10	het	Verified	-0.49485283099608	0.310352004295287	no	713	0.296908708476537	2366	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION	SITE OF POLARIZED GROWTH		Essential 100kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion	exocytosis|establishment of cell polarity|Golgi to plasma membrane transport|vesicle fusion|vesicle docking involved in exocytosis	molecular_function	mating projection tip|exocyst
YOR236W	YOR236W	DFR1	het	Verified	-0.495019634727633	0.310293130364602	no	714	0.331323011996352	2276	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism	tetrahydrofolate biosynthetic process|dihydrofolate metabolic process	dihydrofolate reductase activity|mRNA binding	cytosol
YGL044C	YGL044C	RNA15	het	Verified	-0.498149526842167	0.309189327273878	no	715	0.312110114011556	2322	NA	FT	RNA PROCESSING	NUCLEUS		Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; interacts with the A-rich polyadenylation signal in complex with Rna14p and Hrp1p; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping	mRNA cleavage|mRNA polyadenylation	mRNA binding|protein heterodimerization activity	mRNA cleavage factor complex
YJL085W	YJL085W	EXO70	het	Verified	-0.500686364236422	0.308295935155167	no	716	0.293601991312895	2377	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION	SITE OF POLARIZED GROWTH		Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in an actin-independent manner, targeting and anchoring the exocyst with Sec3p; involved in exocyst assembly; direct downstream effector of Rho3p and Cdc42p; relocalizes from bud neck to cytoplasm upon DNA replication stress	Golgi to plasma membrane transport|exocytosis|exocyst localization|exocyst assembly|vesicle fusion|vesicle docking involved in exocytosis	Rho GTPase binding|phosphatidylinositol-4,5-bisphosphate binding	incipient cellular bud site|cellular bud neck|mating projection tip|cellular bud tip|exocyst
YOL026C	YOL026C	MIM1	het	Verified	-0.500797717103555	0.308256746225009	no	717	0.308549151755801	2351	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial protein required for outer membrane protein import; cooperates with Tom70p to import the subset of proteins with multiple alpha-helical transmembrane segments, including Ugo1p, Tom20p, and others; present in a complex with Mim2p in the outer membrane that may create a local environment to facilitate membrane insertion of substrate proteins; also has a role in assembly of Tom20p into the TOM complex	mitochondrial outer membrane translocase complex assembly|protein import into mitochondrial outer membrane	molecular_function	mitochondrial outer membrane|integral to mitochondrial outer membrane
YHR005C-A	YHR005C-A	TIM10	het	Verified	-0.510217734359127	0.304949464554988	no	718	0.301012786435698	2386	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner membrane	protein import into mitochondrial inner membrane	protein transporter activity|unfolded protein binding	mitochondrion|integral to membrane|mitochondrial inner membrane protein insertion complex|mitochondrial intermembrane space protein transporter complex
YDL163W_d	YDL163W	YDL163W	het	Dubious	-0.51050161782815	0.304850040727466	no	719	0.301048065604546	2358	NA					Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene CDC9/YDL164C encoding DNA ligase	Unknown	Unknown	Unknown
YML114C	YML114C	TAF8	het	Verified	-0.510876826247559	0.304718654487962	no	720	0.304720932767358	2360	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RNA POL II, HOLOENZYME	TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation	RNA polymerase II transcriptional preinitiation complex assembly|transcription from RNA polymerase II promoter	RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly	nucleus|transcription factor TFIID complex
YNL124W	YNL124W	NAF1	het	Verified	-0.514490154362738	0.303454671106114	no	721	0.291858460431411	2402	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		RNA-binding protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p	box H/ACA snoRNP assembly	RNA binding	nucleoplasm|nucleus
YLL008W	YLL008W	DRS1	het	Verified	-0.517745863741393	0.302317797061256	no	722	0.301644064772851	2366	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Nucleolar DEAD-box protein required for ribosome assembly and function, including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles	ribosomal large subunit assembly|rRNA processing	ATP-dependent RNA helicase activity	nucleolus|preribosome, large subunit precursor
YKL013C	YKL013C	ARC19	het	Verified	-0.520144568267583	0.301481408481966	no	723	0.310434609038405	2338	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION	CYTOSKELETON		Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches	mitochondrion inheritance|actin cortical patch assembly	structural molecule activity	Arp2/3 protein complex
YOR098C	YOR098C	NUP1	het	Verified	-0.522036679342726	0.300822396250681	no	724	0.272949018716003	2461	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC; both NUP1 and NUP60 are homologous to human NUP153	poly(A)+ mRNA export from nucleus|NLS-bearing substrate import into nucleus|ribosomal large subunit export from nucleus|protein import into nucleus|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	nucleocytoplasmic transporter activity|structural constituent of nuclear pore	nuclear pore central transport channel|nuclear pore nuclear basket|integral to membrane|nuclear pore
YDR356W	YDR356W	SPC110	het	Verified	-0.524149532212157	0.300087269806662	no	725	0.292752849156863	2383	NA	FT	CYTOSKELETON ORGANIZATION	NUCLEUS|CYTOSKELETON		Inner plaque spindle pole body (SPB) component, ortholog of human kendrin; involved in connecting nuclear microtubules to SPB; interacts with Tub4p-complex and calmodulin; phosphorylated by Mps1p in cell cycle-dependent manner	karyogamy involved in conjugation with cellular fusion|microtubule nucleation	structural constituent of cytoskeleton	central plaque of spindle pole body|inner plaque of spindle pole body
YCR035C	YCR035C	RRP43	het	Verified	-0.524189392109048	0.300073409135982	no	726	0.323827706839899	2305	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp43p (OIP2, EXOSC8); protein abundance increases in response to DNA replication stress	nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear polyadenylation-dependent mRNA catabolic process|nonfunctional rRNA decay|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|polyadenylation-dependent snoRNA 3'-end processing|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|nuclear-transcribed mRNA catabolic process, non-stop decay|ncRNA 3'-end processing	molecular_function	nucleoplasm|nucleolus|nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)|cytoplasm
YBR154C	YBR154C	RPB5	het	Verified	-0.525004023353543	0.299790197019815	no	727	0.345114922513888	2222	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RNA POL II, HOLOENZYME	RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III; contacts DNA and affects transactivation	tRNA transcription from RNA polymerase III promoter|transcription from RNA polymerase I promoter|transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter	RNA-directed RNA polymerase activity|DNA-directed RNA polymerase activity	DNA-directed RNA polymerase III complex|DNA-directed RNA polymerase I complex|DNA-directed RNA polymerase II, core complex
YDL058W	YDL058W	USO1	het	Verified	-0.526027446170758	0.299434568738019	no	728	0.286714711525145	2387	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS|CYTOSKELETON		Essential protein involved in the vesicle-mediated ER to Golgi transport step of secretion; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex	Golgi vesicle docking|ER to Golgi vesicle-mediated transport|SNARE complex assembly	molecular_function	integral to membrane|ER to Golgi transport vesicle membrane|Golgi membrane
YNL222W	YNL222W	SSU72	het	Verified	-0.531044493340356	0.29769397353969	no	729	0.282504561290065	2436	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Phosphatase and transcription/RNA-processing factor; associates with TFIIB and cleavage/polyadenylation factor Pta1p; exhibits phosphatase activity on serine-5 and serine-7 of the RNA polymerase II C-terminal domain; affects start site selection and transcriptional read through in vivo	transcription initiation from RNA polymerase II promoter|mRNA 3'-end processing|mRNA cleavage|termination of RNA polymerase II transcription|termination of RNA polymerase II transcription, poly(A)-coupled|transcription antitermination|transcriptional start site selection at RNA polymerase II promoter|dephosphorylation of RNA polymerase II C-terminal domain|termination of RNA polymerase II transcription, exosome-dependent|snoRNA transcription|transcription elongation from RNA polymerase II promoter	protein tyrosine phosphatase activity|phosphoprotein phosphatase activity|CTD phosphatase activity	mRNA cleavage and polyadenylation specificity factor complex|nucleus
YGR046W	YGR046W	TAM41	het	Verified	-0.535030835638196	0.296314267433381	no	730	0.309010090690626	2314	NA	FT	PROTEIN LOCALIZATION|LIPID METABOLISM|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial protein required for cardiolipin biosynthesis; viability of null mutant is strain-dependent; mRNA is targeted to the bud; mutant displays defect in mitochondrial protein import, likely due to altered membrane lipid composition	cardiolipin biosynthetic process|protein import into mitochondrial matrix	molecular_function	extrinsic to mitochondrial inner membrane|mitochondrion|mitochondrial matrix
YHR040W	YHR040W	BCD1	het	Verified	-0.536728867920625	0.295727456221968	no	731	0.277660506614647	2439	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS	NUCLEUS		Essential protein required for the accumulation of box C/D snoRNA	snoRNA metabolic process	nucleic acid binding	nucleus|cytoplasm
YML085C	YML085C	TUB1	het	Verified	-0.543775680038391	0.293297923181316	no	732	0.343226087225818	2224	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|NUCLEOTIDE METABOLISM|CHROMOSOME SEGREGATION	NUCLEUS|CYTOSKELETON		Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; relative distribution to nuclear foci increases upon DNA replication stress; TUB1 has a paralog, TUB3, that arose from the whole genome duplication	nuclear migration along microtubule|nuclear migration involved in conjugation with cellular fusion|homologous chromosome segregation|mitotic sister chromatid segregation	structural constituent of cytoskeleton	tubulin complex|cytoplasmic microtubule|kinetochore microtubule|nuclear microtubule|spindle pole body|polar microtubule
YDR362C	YDR362C	TFC6	het	Verified	-0.550253598786941	0.291072722708644	no	733	0.315629541924517	2315	NA	FT		NUCLEUS		One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; cooperates with Tfc3p in DNA binding; human homolog is TFIIIC-110	transcription from a RNA polymerase III hybrid type promoter|transcription from RNA polymerase III type 2 promoter|5S class rRNA transcription from RNA polymerase III type 1 promoter	RNA polymerase III type 1 promoter sequence-specific DNA binding|RNA polymerase III type 2 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity|RNA polymerase III type 2 promoter sequence-specific DNA binding|RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity	transcription factor TFIIIC complex
YJL010C	YJL010C	NOP9	het	Verified	-0.551608467525643	0.290608316894845	no	734	0.273977651260162	2424	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Essential subunit of U3-containing 90S preribosome involved in production of 18S rRNA and assembly of small ribosomal subunit; also part of pre-40S ribosome and required for its export into cytoplasm; binds RNA and contains pumilio domain	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal small subunit export from nucleus	RNA binding	preribosome, small subunit precursor|nucleolus|nucleus|90S preribosome
YGR060W	YGR060W	ERG25	het	Verified	-0.551879681152056	0.290515395167012	no	735	0.311694779295738	2321	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol	ergosterol biosynthetic process	C-4 methylsterol oxidase activity	plasma membrane|endoplasmic reticulum membrane
YGR190C_d	YGR190C	YGR190C	het	Dubious	-0.552357581400625	0.290351693446514	no	736	0.267619574706642	2464	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W	Unknown	Unknown	Unknown
YDR189W	YDR189W	SLY1	het	Verified	-0.553383367596017	0.29000046278146	no	737	0.299501138111039	2361	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Hydrophilic protein involved in vesicle trafficking between the ER and Golgi; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex	retrograde vesicle-mediated transport, Golgi to ER|ER to Golgi vesicle-mediated transport|vesicle fusion with Golgi apparatus|positive regulation of SNARE complex assembly	SNARE binding|syntaxin binding	SNARE complex|endoplasmic reticulum|ER to Golgi transport vesicle|Golgi membrane
YMR049C	YMR049C	ERB1	het	Verified	-0.554657471855638	0.289564485220471	no	738	0.28972720415295	2387	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Ytm1p that is required for maturation of the large ribosomal subunit; required for maturation of the 25S and 5.8S ribosomal RNAs; homologous to mammalian Bop1	ribosomal large subunit biogenesis|rRNA processing	molecular_function	PeBoW complex|nucleolus|nucleus|preribosome, large subunit precursor
YMR239C	YMR239C	RNT1	het	Verified	-0.556259755531596	0.2890166473178	no	739	0.280264527247851	2388	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION	NUCLEUS		Nuclear dsRNA-specific ribonuclease (RNase III); involved in rDNA transcription, rRNA processing and U2 snRNA 3' end formation by cleavage of a stem-loop structure at the 3' end of U2 snRNA; involved in polyadenylation-independent transcription termination; involved in the cell wall stress response, regulating the degradation of cell wall integrity and morphogenesis checkpoint genes	U5 snRNA 3'-end processing|mRNA cleavage|chromatin organization|termination of RNA polymerase II transcription, exosome-dependent|U4 snRNA 3'-end processing|U1 snRNA 3'-end processing|rRNA transcription|rRNA processing	ribonuclease III activity	nucleoplasm|nucleolus
YOL102C	YOL102C	TPT1	het	Verified	-0.562305676137219	0.286953885843543	no	740	0.265467881914799	2451	NA	FT	RNA PROCESSING	NUCLEUS		tRNA 2'-phosphotransferase, catalyzes the final step in yeast tRNA splicing: the transfer of the 2'-PO(4) from the splice junction to NAD(+) to form ADP-ribose 1''-2''cyclic phosphate and nicotinamide	tRNA splicing, via endonucleolytic cleavage and ligation	tRNA 2'-phosphotransferase activity	nucleus|cytoplasm
YLR230W_d	YLR230W	YLR230W	het	Dubious	-0.563946043457966	0.286395426681502	no	741	0.295636513662395	2374	NA					Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential CDC42 gene which encodes a small Rho-like GTPase essential for establishment and maintenance of cell polarity	Unknown	Unknown	Unknown
YOR074C	YOR074C	CDC21	het	Verified	-0.564673258364186	0.286148013237045	no	742	0.283839799082617	2397	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S	dTMP biosynthetic process	thymidylate synthase activity	nucleus
YDR091C	YDR091C	RLI1	het	Verified	-0.564738966739113	0.286125662900933	no	743	0.311772676981746	2320	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|NUCLEOTIDE METABOLISM	NUCLEUS	RIBOSOME	Essential iron-sulfur protein required for ribosome biogenesis and translation initiation and termination; facilitates binding of a multifactor complex (MFC) of initiation factors to the small ribosomal subunit; predicted ABC family ATPase; forms a complex with Lto1p and Yae1p that may be involved in protection of the ribosome from damage due to reactive oxygen species	translational termination|ribosomal subunit export from nucleus|ribosomal large subunit biogenesis|translational initiation	ATPase activity|iron ion binding	cytosolic ribosome|nucleus|cytoplasm
YGL099W	YGL099W	LSG1	het	Verified	-0.570622614876391	0.284127742679653	no	744	0.313255119394258	2394	NA	FF|FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS	SITE OF POLARIZED GROWTH		Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm	conjugation with cellular fusion|ribosomal large subunit assembly|ribosomal subunit export from nucleus|ascospore formation	GTPase activity	mating projection tip|cytoplasm
YMR043W	YMR043W	MCM1	het	Verified	-0.571318848753569	0.283891763566103	no	745	0.290583088308954	2414	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CELL CYCLE|AMINO ACID METABOLISM	NUCLEUS|CHROMOSOME		Transcription factor involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexes	regulation of mating type switching|positive regulation of transcription involved in G2/M-phase of mitotic cell cycle|DNA replication initiation|negative regulation of mating-type specific transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|Unknown|positive regulation of mating-type specific transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	DNA replication origin binding|RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding, bending|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity|RNA polymerase II repressing transcription factor binding	nuclear chromatin
YDL016C_d	YDL016C	YDL016C	het	Dubious	-0.572512379148801	0.28348745085947	no	746	0.288221051387207	2410	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CDC7/YDL153C, the catalytic subunit of a complex that regulates DNA replication	Unknown	Unknown	Unknown
YGL116W	YGL116W	CDC20	het	Verified	-0.573273551273227	0.283229745274455	no	747	0.306868088984966	2342	NA	FF|FT	CELL CYCLE|CELL DIVISION|PROTEOLYSIS	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Activator of anaphase-promoting complex/cyclosome (APC/C); APC/C is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; cell-cycle regulated; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress	spindle checkpoint|activation of mitotic anaphase-promoting complex activity|meiotic anaphase I|positive regulation of protein catabolic process|activation of anaphase-promoting complex activity involved in meiotic cell cycle|positive regulation of mitotic metaphase/anaphase transition|cyclin catabolic process	anaphase-promoting complex binding|ubiquitin-protein ligase activator activity	mitotic checkpoint complex|anaphase-promoting complex
YDL015C	YDL015C	TSC13	het	Verified	-0.574931172309885	0.282668923382396	no	748	0.278025940091984	2430	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		Enoyl reductase; catalyzes the last step in each cycle of very long chain fatty acid elongation; localizes to the ER, highly enriched in a structure marking nuclear-vacuolar junctions; coimmunoprecipitates with elongases Fen1p and Sur4p; protein increases in abundance and relative distribution to ER foci increases upon DNA replication stress	very long-chain fatty acid metabolic process	oxidoreductase activity	mitochondrion|integral to membrane|endoplasmic reticulum membrane
YHR148W	YHR148W	IMP3	het	Verified	-0.582827815303439	0.280004609054383	no	749	0.288323363488111	2368	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA	rRNA processing|ribosome biogenesis	snoRNA binding	small-subunit processome|Mpp10 complex|90S preribosome
YCL017C	YCL017C	NFS1	het	Verified	-0.585202722219165	0.279205707348167	no	750	0.281784391790075	2432	NA	FT	KETONE METABOLISM|RNA PROCESSING|AMINO ACID METABOLISM|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS|COFACTOR METABOLISM	NUCLEUS|MITOCHONDRION		Cysteine desulfurase involved in iron-sulfur cluster (Fe/S) biogenesis and in thio-modification of mitochondrial and cytoplasmic tRNAs; essential protein located predominantly in mitochondria	cellular iron ion homeostasis|iron-sulfur cluster assembly|mitochondrial tRNA thio-modification|tRNA thio-modification|tRNA wobble uridine modification	cysteine desulfurase activity	mitochondrion|nucleus
YGL055W	YGL055W	OLE1	het	Verified	-0.585657041549598	0.279053003912775	no	751	0.275107103861069	2445	NA	FF|FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria	unsaturated fatty acid biosynthetic process	electron carrier activity|stearoyl-CoA 9-desaturase activity	integral to endoplasmic reticulum membrane|integral to membrane
YOR361C	YOR361C	PRT1	het	Verified	-0.586043105937161	0.278923273899361	no	752	0.267628703611878	2494	NA	FT	TRANSLATION			eIF3b subunit of the core complex of translation initiation factor 3 (eIF3), essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes	translational initiation	translation initiation factor activity	eukaryotic translation initiation factor 3 complex|multi-eIF complex|cytoplasmic stress granule|cytoplasm
YGL093W	YGL093W	SPC105	het	Verified	-0.590341140689797	0.277480981401082	no	753	0.32604106664412	2325	NA	FF|FT	PROTEIN LOCALIZATION|CELL CYCLE|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION|CHROMOSOME|CYTOSKELETON	KINETOCHORE	Subunit of a kinetochore-microtubule binding complex with Kre28p that bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components	microtubule nucleation|protein localization to kinetochore|sister chromatid biorientation|mitotic cell cycle spindle assembly checkpoint	microtubule binding|structural constituent of cytoskeleton	mitochondrion|condensed nuclear chromosome kinetochore|spindle pole body
YOR160W	YOR160W	MTR10	het	Verified	-0.591132012379815	0.277215986034657	no	754	0.272894197019171	2472	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	NUCLEUS		Nuclear import receptor; mediates the nuclear localization of proteins involved in mRNA-nucleus export; promotes dissociation of mRNAs from the nucleus-cytoplasm mRNA shuttling protein Npl3p; required for retrograde import of mature tRNAs; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress	RNA localization|tRNA transport|RNA import into nucleus|protein import into nucleus|mRNA-binding (hnRNP) protein import into nucleus	nuclear localization sequence binding	integral to membrane|nucleus|cytoplasm
YHR023W	YHR023W	MYO1	het	Verified	-0.59162676668881	0.277050272937472	no	755	0.272082160495586	2463	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Type II myosin heavy chain, required for wild-type cytokinesis and cell separation; localizes to the actomyosin ring; binds to myosin light chains Mlc1p and Mlc2p through its IQ1 and IQ2 motifs respectively	cytokinesis, actomyosin contractile ring assembly|cytokinesis, completion of separation|actomyosin contractile ring contraction|cytokinesis	microfilament motor activity	cellular bud neck contractile ring|incipient cellular bud site|cellular bud neck|myosin II complex
YNL102W	YNL102W	POL1	het	Verified	-0.592135929982651	0.276879784330592	no	756	0.257267497587807	2501	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION|CHROMOSOME		Catalytic subunit of the DNA polymerase I alpha-primase complex, required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis	RNA-dependent DNA replication|lagging strand elongation|DNA synthesis involved in DNA repair|DNA replication|DNA replication initiation|premeiotic DNA replication	DNA-directed DNA polymerase activity	mitochondrion|alpha DNA polymerase:primase complex|replication fork
YPL142C_d	YPL142C	YPL142C	het	Dubious	-0.592460018826356	0.276771292952429	no	757	0.280831480480744	2421	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPL33A/YPL143W, a component of the large (60S) ribosomal subunit	Unknown	Unknown	Unknown
YIL021W	YIL021W	RPB3	het	Verified	-0.598201046382677	0.274852896665514	no	758	0.306940758136191	2350	NA	FF|FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RNA POL II, HOLOENZYME	RNA polymerase II third largest subunit B44, part of central core; similar to prokaryotic alpha subunit	termination of RNA polymerase II transcription|transcription from RNA polymerase II promoter	RNA-directed RNA polymerase activity|DNA-directed RNA polymerase activity	nucleoplasm|DNA-directed RNA polymerase II, core complex
YDR045C	YDR045C	RPC11	het	Verified	-0.59881676839585	0.274647539530606	no	759	0.273040730343962	2437	NA	FT		NUCLEUS		RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS	termination of RNA polymerase III transcription|tRNA transcription from RNA polymerase III promoter	DNA-directed RNA polymerase activity	DNA-directed RNA polymerase III complex
YHR068W	YHR068W	DYS1	het	Verified	-0.599214145343141	0.274515045575387	no	760	0.273513608321472	2427	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Deoxyhypusine synthase, catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels; tetrameric	peptidyl-lysine modification to hypusine	transferase activity, transferring alkyl or aryl (other than methyl) groups	cytoplasm
YER003C	YER003C	PMI40	het	Verified	-0.603626947058149	0.273045846494362	no	761	0.277902337165588	2458	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	NUCLEUS		Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation	protein glycosylation|cell wall mannoprotein biosynthetic process|GDP-mannose biosynthetic process	mannose-6-phosphate isomerase activity	nucleus|cytoplasm
YBR265W	YBR265W	TSC10	het	Verified	-0.606197214532524	0.272191901119726	no	762	0.283166112687496	2397	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis, essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine, member of short chain dehydrogenase/reductase protein family	3-keto-sphinganine metabolic process|sphingolipid biosynthetic process	oxidoreductase activity, acting on NADH or NADPH	mitochondrial outer membrane|endoplasmic reticulum|cytoplasm
YEL002C	YEL002C	WBP1	het	Verified	-0.611468639571146	0.270444686798117	no	763	0.273708794117819	2401	NA	FT	CELL CYCLE|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Beta subunit of the oligosaccharyl transferase (OST) glycoprotein complex; required for N-linked glycosylation of proteins in the endoplasmic reticulum	cell cycle|protein N-linked glycosylation	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	nuclear envelope|oligosaccharyltransferase complex|endoplasmic reticulum
YCR057C	YCR057C	PWP2	het	Verified	-0.611640231010109	0.270387907127574	no	764	0.265961780917672	2464	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|CELL DIVISION	NUCLEUS		Conserved 90S pre-ribosomal component essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesis	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|establishment of cell polarity|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|cytokinesis	snoRNA binding	small-subunit processome|nucleolus|Pwp2p-containing subcomplex of 90S preribosome|cytoplasm|90S preribosome
YJL008C	YJL008C	CCT8	het	Verified	-0.613026633422813	0.269929364720048	no	765	0.252641966468347	2536	NA					Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo	protein folding	unfolded protein binding	chaperonin-containing T-complex|cytoplasm
YDR331W	YDR331W	GPI8	het	Verified	-0.613861060188391	0.269653571949345	no	766	0.270052771628623	2454	NA	FT	LIPID METABOLISM|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog	attachment of GPI anchor to protein	GPI-anchor transamidase activity	endoplasmic reticulum membrane|GPI-anchor transamidase complex
YNL182C	YNL182C	IPI3	het	Verified	-0.616350023076015	0.268831765187619	no	767	0.252640710295363	2509	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; highly conserved protein which contains several WD40 motifs; IPI3 is an essential gene	ribosomal large subunit assembly|rRNA processing	molecular_function	nucleoplasm|nucleus
YPR016C	YPR016C	TIF6	het	Verified	-0.619513092583259	0.267789199770245	no	768	0.312034326608209	2317	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION	NUCLEUS		Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits	ribosomal subunit export from nucleus|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal large subunit biogenesis|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA processing	ribosomal large subunit binding	nucleolus|nucleus|preribosome, large subunit precursor|cytoplasm
YDR170C	YDR170C	SEC7	het	Verified	-0.620005974866387	0.267626926642444	no	769	0.262237074778554	2470	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|RESPONSE TO NUTRIENT LEVELS	GOLGI APPARATUS		Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles	ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|autophagic vacuole assembly	ARF guanyl-nucleotide exchange factor activity	trans-Golgi network|cytosol|late endosome|integral to membrane|Golgi-associated vesicle
YGL128C	YGL128C	CWC23	het	Verified	-0.623035930593642	0.266630455309373	no	770	0.230823672270715	2583	NA	FT	RNA PROCESSING	NUCLEUS		Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; has similarity to E. coli DnaJ and other DnaJ-like proteins and to S. pombe Cwf23p	spliceosomal complex disassembly	molecular_function	U2-type spliceosomal complex
YLR347C	YLR347C	KAP95	het	Verified	-0.623108013013362	0.266606772195289	no	771	0.272035716030026	2443	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|LIPID METABOLISM	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Karyopherin beta, forms a complex with Srp1p/Kap60p; interacts with nucleoporins to mediate nuclear import of NLS-containing cargo proteins via the nuclear pore complex; regulates PC biosynthesis; GDP-to-GTP exchange factor for Gsp1p	protein targeting to membrane|regulation of protein desumoylation|protein import into nucleus|phosphatidylcholine biosynthetic process|nuclear pore complex assembly	protein transporter activity|Ran guanyl-nucleotide exchange factor activity	integral to membrane|nuclear exosome (RNase complex)|nuclear pore|cytoplasm
YJR006W	YJR006W	POL31	het	Verified	-0.62693808306759	0.265349911270378	no	772	0.254818387584616	2498	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Subunit of DNA polymerase delta (polymerase III); essential for cell viability; involved in DNA replication and DNA repair	mismatch repair|RNA-dependent DNA replication|lagging strand elongation|base-excision repair|postreplication repair|DNA replication, removal of RNA primer|leading strand elongation|nucleotide-excision repair	single-stranded DNA specific 3'-5' exodeoxyribonuclease activity|DNA-directed DNA polymerase activity	delta DNA polymerase complex
YGL112C	YGL112C	TAF6	het	Verified	-0.631163130910937	0.26396693309923	no	773	0.289303394072783	2413	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS	RNA POL II, HOLOENZYME|HISTONE ACETYLTRANSFERASE	Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4	histone acetylation|RNA polymerase II transcriptional preinitiation complex assembly|chromatin modification|transcription from RNA polymerase II promoter	chromatin binding|RNA polymerase II activating transcription factor binding|protein complex scaffold|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly	SLIK (SAGA-like) complex|SAGA complex|transcription factor TFIID complex
YMR076C	YMR076C	PDS5	het	Verified	-0.632678632356092	0.26347176313829	no	774	0.265005945230193	2456	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Protein required for establishment and maintenance of sister chromatid condensation and cohesion, colocalizes with cohesin on chromosomes, may function as a protein-protein interaction scaffold; also required during meiosis	double-strand break repair|meiosis|synapsis|mitotic chromosome condensation|mitotic sister chromatid cohesion	structural molecule activity	condensed nuclear chromosome
YJL174W	YJL174W	KRE9	het	Verified	-0.647368653315517	0.258696689269372	no	775	0.252364096836795	2537	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects	(1->6)-beta-D-glucan metabolic process|fungal-type cell wall organization	molecular_function	extracellular region
YHR070W	YHR070W	TRM5	het	Verified	-0.64997056203345	0.257855618546347	no	776	0.263788928833018	2475	NA	FT	RNA PROCESSING	NUCLEUS|MITOCHONDRION		tRNA(m(1)G37)methyltransferase, methylates a tRNA base adjacent to the anticodon that has a role in prevention of frameshifting; highly conserved across Archaea, Bacteria, and Eukarya	tRNA methylation	tRNA (guanine) methyltransferase activity	nucleus|mitochondrial matrix|cytoplasm
YLR310C	YLR310C	CDC25	het	Verified	-0.650465769140378	0.257695703022098	no	777	0.286999117343666	2411	NA	FT	CELL CYCLE|SIGNALING|CELL DIVISION	NUCLEUS|PLASMA MEMBRANE		Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor); indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1	regulation of cell cycle|replicative cell aging|Ras protein signal transduction|traversing start control point of mitotic cell cycle	Ras guanyl-nucleotide exchange factor activity	cytosol|nucleus|plasma membrane|cytoplasm
YLL036C	YLL036C	PRP19	het	Verified	-0.650562344799216	0.25766452217822	no	778	0.241559263616908	2581	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION		Splicing factor associated with the spliceosome; contains a U-box, a motif found in a class of ubiquitin ligases, and a WD40 domain	generation of catalytic spliceosome for first transesterification step	ubiquitin-protein ligase activity|first spliceosomal transesterification activity	mitochondrion|nucleus|Prp19 complex|cytoplasm|U2-type catalytic step 1 spliceosome
YNL131W	YNL131W	TOM22	het	Verified	-0.653214953209357	0.256808855732971	no	779	0.308142771325875	2328	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Component of the TOM (translocase of outer mitochondrial membrane) complex responsible for initial import of mitochondrially directed proteins; acts as a receptor for precursor proteins and mediates interaction between TOM and TIM complexes	protein import into mitochondrial matrix|protein import into mitochondrial outer membrane	protein channel activity	mitochondrial outer membrane|mitochondrion|integral to membrane|integral to mitochondrial outer membrane|mitochondrial outer membrane translocase complex
YBR038W	YBR038W	CHS2	het	Verified	-0.654814405391173	0.256293627347827	no	780	0.28289827135417	2395	NA	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM	SITE OF POLARIZED GROWTH		Chitin synthase II; catalyzes transfer of N-acetylglucosamine (GlcNAc) to chitin upon activation of zymogenic form; required for chitin synthesis in the primary septum during cytokinesis; localization regulated by Cdk1p during mitosis; phosphorylation by Dbf2p kinase regulates its dynamics and chitin synthesis during cytokinesis	actomyosin contractile ring contraction|cytokinesis	chitin synthase activity	integral to membrane|cellular bud neck
YER146W	YER146W	LSM5	het	Verified	-0.657945048641461	0.25528672105255	no	781	0.252711205356267	2550	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA	nuclear-transcribed mRNA catabolic process|mRNA splicing, via spliceosome	RNA binding	U6 snRNP|nucleolus|small nucleolar ribonucleoprotein complex|U4/U6 x U5 tri-snRNP complex
YAL025C	YAL025C	MAK16	het	Verified	-0.660494551148841	0.254468257009665	no	782	0.245721285315204	2563	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Essential nuclear protein, constituent of 66S pre-ribosomal particles; required for maturation of 25S and 5.8S rRNAs; required for maintenance of M1 satellite double-stranded RNA of the L-A virus	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal large subunit biogenesis|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	nucleolus|preribosome, large subunit precursor
YDL195W	YDL195W	SEC31	het	Verified	-0.661830777719872	0.254039839453156	no	783	0.309400453371982	2347	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH		Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance	COPII-coated vesicle budding	structural molecule activity	COPII vesicle coat|mating projection tip
YER165W	YER165W	PAB1	het	Verified	-0.662083003009594	0.253959014099603	no	784	0.269819400239936	2462	NA	FF|FT	RNA PROCESSING|TRANSLATION|RNA LOCALIZATION	NUCLEUS	RIBOSOME	Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G	regulation of nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	poly(A) RNA binding	ribosome|nucleus|cytoplasmic stress granule|cytoplasm
YPR183W	YPR183W	DPM1	het	Verified	-0.666304118695899	0.252608366767873	no	785	0.226252059809624	2604	NA	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		Dolichol phosphate mannose (Dol-P-Man) synthase of the ER membrane, catalyzes the formation of Dol-P-Man from Dol-P and GDP-Man; required for glycosyl phosphatidylinositol membrane anchoring, O mannosylation, and protein glycosylation	GPI anchor biosynthetic process|protein O-linked glycosylation|protein N-linked glycosylation	dolichyl-phosphate beta-D-mannosyltransferase activity	mitochondrial outer membrane|mitochondrion|endoplasmic reticulum|nuclear outer membrane-endoplasmic reticulum membrane network
YOR203W_d	YOR203W	YOR203W	het	Dubious	-0.666939620955531	0.252405350777737	no	786	0.256653414720186	2495	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps 5' end of essential DED1 gene required for translation initiation	Unknown	Unknown	Unknown
YJR076C	YJR076C	CDC11	het	Verified	-0.667149957566205	0.252338176107483	no	787	0.257555239364412	2480	NA	FT	CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells	maintenance of cell polarity|cell cycle cytokinesis|positive regulation of protein kinase activity	structural molecule activity|GTP binding|1-phosphatidylinositol binding	spindle microtubule|septin complex|prospore membrane|ascospore wall|mating projection base|meiotic spindle|cellular bud neck septin ring|septin filament array|cytoplasmic microtubule|mating projection tip
YJL097W	YJL097W	PHS1	het	Verified	-0.667731915444595	0.25215236681689	no	788	0.248627016921135	2530	NA	FT	KETONE METABOLISM|LIPID METABOLISM|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Essential 3-hydroxyacyl-CoA dehydratase of the ER membrane, involved in elongation of very long-chain fatty acids; evolutionarily conserved, similar to mammalian PTPLA and PTPLB; involved in sphingolipid biosynthesis and protein trafficking	vacuolar transport|sphingolipid biosynthetic process	enoyl-CoA hydratase activity	fungal-type vacuole membrane|integral to endoplasmic reticulum membrane|integral to membrane|endoplasmic reticulum|fungal-type vacuole|nuclear outer membrane-endoplasmic reticulum membrane network
YGL001C	YGL001C	ERG26	het	Verified	-0.668946799633544	0.251764707572421	no	789	0.250571515418474	2546	NA	FT	LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis	ergosterol biosynthetic process	C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity	endoplasmic reticulum|endoplasmic reticulum membrane
YGR253C	YGR253C	PUP2	het	Verified	-0.670229272198293	0.251355823144056	no	790	0.278741232472256	2405	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION		Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta	proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process	molecular_function	mitochondrion|proteasome core complex, alpha-subunit complex|proteasome storage granule|nucleus|nuclear outer membrane-endoplasmic reticulum membrane network
YJR067C	YJR067C	YAE1	het	Verified	-0.67449122384079	0.249999531710468	no	791	0.250475630665716	2530	NA	FT		NUCLEUS		Protein that forms a complex with Lto1p and Rli1p; essential for growth under standard (aerobic) conditions but not under anaerobic conditions; may have a role in protection of ribosomal assembly and function from damage due to reactive oxygen species	biological_process	molecular_function	nucleus|cytoplasm
YDR427W	YDR427W	RPN9	het	Verified	-0.675697179513416	0.249616463539986	no	792	0.27302672702473	2448	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS			Non-ATPase regulatory subunit of the 26S proteasome; has similarity to putative proteasomal subunits in other species; null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defects; protein abundance increases in response to DNA replication stress	proteasome assembly|ubiquitin-dependent protein catabolic process	structural molecule activity	proteasome storage granule|proteasome regulatory particle, lid subcomplex
YER148W	YER148W	SPT15	het	Verified	-0.676966615470402	0.249213568143968	no	793	0.254173993492666	2518	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RNA POL II, HOLOENZYME	TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability	transposon integration|transcription of nuclear large rRNA transcript from RNA polymerase I promoter|RNA polymerase II transcriptional preinitiation complex assembly|RNA polymerase III transcriptional preinitiation complex assembly	RNA polymerase III regulatory region DNA binding|RNA polymerase I transcription factor recruiting transcription factor activity|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly|RNA polymerase II activating transcription factor binding|DNA binding, bending|sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding|TFIIIB-type transcription factor activity|chromatin binding|RNA polymerase I transcription factor binding	transcription factor TFIIIB complex|RNA polymerase I upstream activating factor complex|nucleus|RNA polymerase I core factor complex|transcription factor TFIID complex
YKR008W	YKR008W	RSC4	het	Verified	-0.677100393893685	0.249171129508683	no	794	0.269372780935986	2479	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION	NUCLEUS	RSC COMPLEX	Component of the RSC chromatin remodeling complex; found in close proximity to nucleosomal DNA; displaced from the surface of nucleosomal DNA after chromatin remodeling; acetylated (K25) by Gcn5p, altering replication stress tolerance; contains tandem bromodomains that recognize histone H3 acetylated on K14 (H3K14ac) by Gcn5p	G2/M transition of mitotic cell cycle|ATP-dependent chromatin remodeling|nucleosome disassembly|transcription elongation from RNA polymerase II promoter	histone acetyl-lysine binding|DNA translocase activity	RSC complex
YPR107C	YPR107C	YTH1	het	Verified	-0.679620604388265	0.248372359905954	no	795	0.32684927057705	2278	NA	FF|FT	RNA PROCESSING	NUCLEUS		Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation	mRNA cleavage|mRNA polyadenylation	RNA binding	mRNA cleavage and polyadenylation specificity factor complex
YGL018C	YGL018C	JAC1	het	Verified	-0.685816926933014	0.246414280428694	no	796	0.23235524775508	2585	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Specialized J-protein that functions with Hsp70 in Fe-S cluster biogenesis in mitochondria, involved in iron metabolism; contains a J domain typical to J-type chaperones; localizes to the mitochondrial matrix	iron-sulfur cluster assembly|aerobic respiration	chaperone binding	mitochondrion
YBR002C	YBR002C	RER2	het	Verified	-0.687560945662839	0.245864654511538	no	797	0.25038639023524	2548	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting	dolichol biosynthetic process|protein glycosylation|ER to Golgi vesicle-mediated transport	dehydrodolichyl diphosphate synthase activity|prenyltransferase activity	endoplasmic reticulum
YML049C	YML049C	RSE1	het	Verified	-0.688872210548616	0.245451844316189	no	798	0.265135339582759	2497	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING	NUCLEUS		Protein involved in pre-mRNA splicing; component of the pre-spliceosome; associates with U2 snRNA; involved in ER to Golgi transport	spliceosomal complex assembly|mRNA splicing, via spliceosome	U2 snRNA binding	U2 snRNP|U2-type prespliceosome
YLR458W_d	YLR458W	YLR458W	het	Dubious	-0.691246014321785	0.244705475798621	no	799	0.234246275125349	2595	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential NBP1 gene required for mitosis	Unknown	Unknown	Unknown
YOR117W	YOR117W	RPT5	het	Verified	-0.691900342369847	0.244499957812209	no	800	0.287867343195888	2420	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS	NUCLEUS		One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription; similar to human TBP1	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|proteasome regulatory particle assembly|ubiquitin-dependent protein catabolic process	ATPase activity	proteasome regulatory particle, base subcomplex
YJL195C_d	YJL195C	YJL195C	het	Dubious	-0.693522421739604	0.243990879913699	no	801	0.268975633356931	2432	NA	FF				Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL194W/CDC6	Unknown	Unknown	Unknown
YIL143C	YIL143C	SSL2	het	Verified	-0.70145201886394	0.2415104841228	no	802	0.222008357592959	2640	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|RNA LOCALIZATION	NUCLEUS	RNA POL II, HOLOENZYME	Component of RNA polymerase transcription factor TFIIH holoenzyme; has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; interacts functionally with TFIIB and has roles in transcription start site selection and in gene looping to juxtapose initiation and termination regions; involved in DNA repair; homolog of human ERCC3	poly(A)+ mRNA export from nucleus|promoter clearance from RNA polymerase II promoter|transcriptional open complex formation at RNA polymerase II promoter|nucleotide-excision repair, DNA incision|transcription from RNA polymerase II promoter|phosphorylation of RNA polymerase II C-terminal domain|regulation of transposition, RNA-mediated|regulation of mitotic recombination	ATP-dependent DNA helicase activity|core RNA polymerase binding transcription factor activity	core TFIIH complex|holo TFIIH complex|nucleotide-excision repair factor 3 complex
YGL142C	YGL142C	GPI10	het	Verified	-0.70331025636882	0.240931210176807	no	803	0.228378592511642	2613	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Integral membrane protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; putative alpha 1,2 mannosyltransferase required for addition of the third mannose onto the GPI core structure; human PIG-Bp is a functional homolog	GPI anchor biosynthetic process	dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity	integral to membrane
YJL111W	YJL111W	CCT7	het	Verified	-0.7079285645612	0.239494810023257	no	804	0.280051735168189	2365	NA	FF				Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance	protein folding	unfolded protein binding	chaperonin-containing T-complex|cytoplasm
YNL267W	YNL267W	PIK1	het	Verified	-0.708076180144343	0.239448975422994	no	805	0.269651667606636	2454	NA	FF|FT	LIPID METABOLISM|SIGNALING	NUCLEUS|GOLGI APPARATUS		Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton	phosphatidylinositol phosphorylation	1-phosphatidylinositol 4-kinase activity	trans-Golgi network|nucleus
YJL202C_d	YJL202C	YJL202C	het	Dubious	-0.708880398934071	0.23919934985461	no	806	0.244234874489657	2555	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 3' end of essential PRP21 gene encoding a subunit of the SF3a splicing factor complex	Unknown	Unknown	Unknown
YKL152C	YKL152C	GPM1	het	Verified	-0.710515818300263	0.238692162610935	no	807	0.211900100842357	2690	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis	gluconeogenesis|glycolysis	phosphoglycerate mutase activity	cytosol|mitochondrion
YBR088C	YBR088C	POL30	het	Verified	-0.714071185492193	0.237591581263689	no	808	0.234461395230082	2577	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Proliferating cell nuclear antigen (PCNA), functions as the sliding clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair	lagging strand elongation|postreplication repair|base-excision repair|nucleotide-excision repair|mismatch repair|meiotic mismatch repair|leading strand elongation|chromatin silencing at telomere|mitotic sister chromatid cohesion|chromatin silencing at silent mating-type cassette	DNA polymerase processivity factor activity	PCNA complex|nucleus|replication fork
YOR146W_d	YOR146W	YOR146W	het	Dubious	-0.715545916850296	0.237135889368751	no	809	0.28164548795846	2442	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene PNO1/YOR145C	Unknown	Unknown	Unknown
YGR116W	YGR116W	SPT6	het	Verified	-0.718108766867095	0.236345112515546	no	810	0.243602280583641	2548	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|RNA LOCALIZATION	NUCLEUS|MITOCHONDRION|CHROMOSOME		Nucleosome remodeling protein; functions in various aspects of transcription, chromatin maintenance, and RNA processing; required for the maintenance of chromatin structure during transcription in order to inhibit transcription from promoters within the coding region	poly(A)+ mRNA export from nucleus|regulation of transcription by chromatin organization|regulation of mRNA 3'-end processing|transcription antitermination|positive regulation of transcription involved in G1/S phase of mitotic cell cycle|regulation of transcriptional start site selection at RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter by glucose|negative regulation of transcription from RNA polymerase II promoter|nucleosome organization|chromatin maintenance|regulation of nucleosome density|nucleosome assembly|chromatin remodeling|regulation of histone H3-K36 methylation|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter in response to stress	core RNA polymerase II binding transcription factor activity|nucleosome binding|histone binding|DNA binding transcription antitermination factor activity	mitochondrion|nucleus|transcriptionally active chromatin
YNR026C	YNR026C	SEC12	het	Verified	-0.719093721035464	0.236041587908785	no	811	0.221922749985301	2672	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Guanine nucleotide exchange factor (GEF), activates Sar1p by catalyzing the exchange of GDP for GTP; required for the initiation of COPII vesicle formation in ER to Golgi transport; glycosylated integral membrane protein of the ER	regulation of COPII vesicle coating	Sar guanyl-nucleotide exchange factor activity	Golgi apparatus|endoplasmic reticulum
YDL029W	YDL029W	ARP2	het	Verified	-0.720818471450467	0.235510604567249	no	812	0.246558225102477	2540	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL WALL ORG/BIOGENESIS|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|VACUOLAR TRANSPORT	MITOCHONDRION|CYTOSKELETON		Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity	mitochondrion inheritance|Arp2/3 complex-mediated actin nucleation|ascospore wall assembly|actin filament organization|establishment of mitochondrion localization|ATP catabolic process|CVT pathway	ATPase activity|ATP binding	Arp2/3 protein complex|mitochondrion
YNL118C	YNL118C	DCP2	het	Verified	-0.721380361587841	0.235337762957954	no	813	0.22437211826053	2656	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING	NUCLEUS		Catalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex; removes the 5' cap structure from mRNAs prior to their degradation; nudix hydrolase family member; forms cytoplasmic foci upon DNA replication stress	deadenylation-dependent decapping of nuclear-transcribed mRNA|deadenylation-independent decapping of nuclear-transcribed mRNA|stress granule assembly	hydrolase activity|mRNA binding|m7G(5')pppN diphosphatase activity	nucleus|cytoplasmic mRNA processing body|cytoplasm
YBR029C	YBR029C	CDS1	het	Verified	-0.724552523170699	0.234363297034508	no	814	0.263222661412394	2426	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase); an enzyme that catalyzes that conversion of CTP + phosphate into diphosphate + CDP-diaclglyerol, a critical step in the synthesis of all major yeast phospholipids	phosphatidylserine metabolic process|phosphatidylglycerol biosynthetic process	phosphatidate cytidylyltransferase activity	mitochondrion|integral to membrane|endoplasmic reticulum
YBL004W	YBL004W	UTP20	het	Verified	-0.725267381575564	0.234144006229636	no	815	0.225342555859205	2634	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	nucleoplasm|small-subunit processome|preribosome, small subunit precursor|nucleolus|90S preribosome|cytoplasm
YLR198C_d	YLR198C	YLR198C	het	Dubious	-0.727872449460921	0.23334583477826	no	816	0.258222923816769	2525	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIK1/YLR197W	Unknown	Unknown	Unknown
YLL018C	YLL018C	DPS1	het	Verified	-0.729458186962617	0.232860717960393	no	817	0.225510326239749	2613	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION	NUCLEUS		Aspartyl-tRNA synthetase, primarily cytoplasmic; homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulation	cytoplasmic translation|aspartyl-tRNA aminoacylation	RNA binding|aspartate-tRNA ligase activity	nucleus|cytoplasm
YER125W	YER125W	RSP5	het	Verified	-0.729676886599916	0.2327938562582	no	818	0.267414508831628	2507	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|PROTEIN COMPLEX ORG/BIOGENESIS|LIPID METABOLISM|MEMBRANE ORGANIZATION|RNA PROCESSING|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION|PROTEOLYSIS|MITOCHONDRION ORGAN	NUCLEUS|MITOCHONDRION|GOLGI APPARATUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE	UBIQUITIN LIGASE COMPLEX	E3 ubiquitin ligase of the NEDD4 family; involved in regulating many cellular processes including MVB sorting, heat shock response, transcription, endocytosis, and ribosome stability; human homolog is involved in Liddle syndrome; mutant tolerates aneuploidy; ubiquitylates Sec23p	cellular response to UV|late endosome to vacuole transport via multivesicular body sorting pathway|chromatin assembly or disassembly|response to drug|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|ubiquitin-dependent endocytosis|protein monoubiquitination|positive regulation of fatty acid biosynthetic process|positive regulation of receptor-mediated endocytosis|regulation of phosphate metabolic process|regulation of ubiquinone biosynthetic process|regulation of dolichol biosynthetic process|regulation of multivesicular body size|positive regulation of transcription from RNA polymerase II promoter|regulation of nitrogen utilization|proteasomal ubiquitin-dependent protein catabolic process|positive regulation of endocytosis|regulation of actin cytoskeleton organization|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|regulation of protein localization|mitochondrion organization|regulation of mRNA export from nucleus|regulation of ergosterol biosynthetic process|ribophagy|Unknown|protein polyubiquitination	ubiquitin binding|ubiquitin-protein ligase activity|phosphatidylinositol binding	mitochondrion|ubiquitin ligase complex|Golgi apparatus|cytoplasm|cellular bud tip|endosome membrane|extrinsic to internal side of plasma membrane|plasma membrane|nucleus
YLR457C	YLR457C	NBP1	het	Verified	-0.730184303919702	0.232638767760668	no	819	0.225092516536957	2613	NA	FT	CELL CYCLE|CYTOSKELETON ORGANIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON		Spindle pole body (SPB) component; required for the insertion of the duplication plaque into the nuclear membrane during SPB duplication; essential for bipolar spindle formation; component of the Mps2p-Bbp1p complex; NBP1 has a paralog, YPR174C, that arose from the whole genome duplication	establishment of spindle pole body localization to nuclear envelope|spindle pole body duplication associated with nuclear envelope	lipid binding	integral to nuclear inner membrane|central plaque of spindle pole body|spindle pole body
YAL033W	YAL033W	POP5	het	Verified	-0.735128850623579	0.231130512602776	no	820	0.222540507892808	2641	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs	tRNA processing|intronic box C/D snoRNA processing|mRNA cleavage|rRNA processing	ribonuclease MRP activity|ribonuclease P activity	nucleolar ribonuclease P complex|ribonuclease MRP complex
YOR148C	YOR148C	SPP2	het	Verified	-0.737296829866335	0.230470929817131	no	821	0.230365478240964	2600	NA	FT	RNA PROCESSING	NUCLEUS		Essential protein that promotes the first step of splicing and is required for the final stages of spliceosome maturation; interacts with Prp2p, which may release Spp2p from the spliceosome following the first cleavage reaction	mRNA splicing, via spliceosome	molecular_function	spliceosomal complex
YGL111W	YGL111W	NSA1	het	Verified	-0.739032374842015	0.22994366935095	no	822	0.219781637236331	2616	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis	ribosomal large subunit biogenesis	molecular_function	nucleolus|nucleus|preribosome, large subunit precursor
YDL153C	YDL153C	SAS10	het	Verified	-0.739416212563259	0.229827150269583	no	823	0.223198947869275	2612	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|GENE SILENCING	NUCLEUS		Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	small-subunit processome|nucleolus|nucleus
YPL131W	YPL131W	RPL5	het	Verified	-0.742285427220953	0.228957209632352	no	824	0.2616668522937	2488	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L5; homologous to mammalian ribosomal protein L5 and bacterial L18; binds 5S rRNA and is required for 60S subunit assembly	cytoplasmic translation|ribosomal large subunit assembly	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YGR278W	YGR278W	CWC22	het	Verified	-0.742862245776355	0.228782542639301	no	825	0.207020564696516	2692	NA	FT	RNA PROCESSING	NUCLEUS		Spliceosome-associated protein that is required for pre-mRNA splicing; necessary for Prp2p function at the first catalytic step of splicing; has similarity to S. pombe Cwf22p; CWC22 is an essential protein	mRNA splicing, via spliceosome	molecular_function	U2-type spliceosomal complex|U2-type catalytic step 1 spliceosome
YML025C	YML025C	YML6	het	Verified	-0.750435886819668	0.22649611199684	no	826	0.209450869705878	2650	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YKL182W	YKL182W	FAS1	het	Verified	-0.752543954103948	0.225862003757985	no	827	0.298043777049551	2396	NA	FF|FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities	fatty acid biosynthetic process	palmitoyltransferase activity|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|fatty acid synthase activity|3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity	cytosol|fatty acid synthase complex|mitochondrion|lipid particle|cytoplasm
YNL002C	YNL002C	RLP7	het	Verified	-0.754368865903954	0.225313880567409	no	828	0.242571661421406	2554	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION	NUCLEUS		Nucleolar protein with similarity to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs	ribosomal large subunit biogenesis|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	rRNA binding	nucleolus|preribosome, large subunit precursor
YGR030C	YGR030C	POP6	het	Verified	-0.761001184243232	0.223328179955958	no	829	0.230424650597422	2628	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs	tRNA processing|intronic box C/D snoRNA processing|mRNA cleavage|rRNA processing	ribonuclease MRP activity|ribonuclease P activity	nucleolar ribonuclease P complex|ribonuclease MRP complex
YLR163C	YLR163C	MAS1	het	Verified	-0.770917919086835	0.220377792584365	no	830	0.288080590533672	2398	NA	FF|FT	PROTEIN LOCALIZATION|PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Smaller subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins	protein processing involved in protein targeting to mitochondrion	metalloendopeptidase activity	mitochondrion|mitochondrial processing peptidase complex
YDL087C	YDL087C	LUC7	het	Verified	-0.771834668212683	0.22010617785859	no	831	0.226319394329619	2634	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING	NUCLEUS		Essential protein associated with the U1 snRNP complex; splicing factor involved in recognition of 5' splice site; contains two zinc finger motifs; N-terminal zinc finger binds pre-mRNA	mRNA splice site selection	mRNA binding	U1 snRNP|U2-type prespliceosome
YIL004C	YIL004C	BET1	het	Verified	-0.777068030292248	0.218559317223272	no	832	0.216376932646817	2680	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Type II membrane protein required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins	retrograde vesicle-mediated transport, Golgi to ER|ER to Golgi vesicle-mediated transport|vesicle fusion	SNAP receptor activity	SNARE complex|integral to membrane|endoplasmic reticulum membrane|ER to Golgi transport vesicle
YMR005W	YMR005W	TAF4	het	Verified	-0.779027139211698	0.217981864024787	no	833	0.220697967796642	2611	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RNA POL II, HOLOENZYME	TFIID subunit (48 kDa), involved in RNA polymerase II transcription initiation; potential Cdc28p substrate	RNA polymerase II transcriptional preinitiation complex assembly|transcription from RNA polymerase II promoter	chromatin binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly|RNA polymerase II activating transcription factor binding	transcription factor TFIID complex
YHR069C	YHR069C	RRP4	het	Verified	-0.781997467864408	0.217108030853156	no	834	0.243020151244405	2546	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|RNA LOCALIZATION	NUCLEUS		Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; has similarity to human hRrp4p (EXOSC2)	nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear polyadenylation-dependent mRNA catabolic process|nonfunctional rRNA decay|U4 snRNA 3'-end processing|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription|polyadenylation-dependent snoRNA 3'-end processing|nuclear-transcribed mRNA catabolic process, non-stop decay|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)
YKL144C	YKL144C	RPC25	het	Verified	-0.783217016685759	0.216749841901275	no	835	0.269519370856905	2473	NA	FT		NUCLEUS		RNA polymerase III subunit C25, required for transcription initiation; forms a heterodimer with Rpc17p; paralog of Rpb7p	transcription initiation from RNA polymerase III promoter|tRNA transcription from RNA polymerase III promoter	DNA-directed RNA polymerase activity	DNA-directed RNA polymerase III complex
YIR012W	YIR012W	SQT1	het	Verified	-0.7854183830147	0.216104153028214	no	836	0.202568128701811	2713	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS		RIBOSOME	Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress	ribosomal large subunit assembly	molecular_function	cytosol|cytosolic ribosome|cytoplasm
YKR079C	YKR079C	TRZ1	het	Verified	-0.786002628147669	0.215932973717965	no	837	0.188461544408112	2741	NA	FT	RNA PROCESSING	NUCLEUS|MITOCHONDRION		tRNA 3'-end processing endonuclease tRNase Z; also localized to mitochondria and interacts genetically with Rex2 exonuclease; homolog of the human candidate prostate cancer susceptibility gene ELAC2	tRNA 3'-trailer cleavage, endonucleolytic	3'-tRNA processing endoribonuclease activity	mitochondrion|nucleus|cytoplasm
YPR035W	YPR035W	GLN1	het	Verified	-0.789733682453258	0.214841658074094	no	838	0.189296033751646	2706	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Glutamine synthetase (GS); synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress	nitrogen compound metabolic process|glutamine biosynthetic process	glutamate-ammonia ligase activity	cytoplasm
YJL011C	YJL011C	RPC17	het	Verified	-0.791538462655523	0.21431492031806	no	839	0.250739935582776	2543	NA	FT		NUCLEUS		RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex; protein abundance increases in response to DNA replication stress	transcription initiation from RNA polymerase III promoter|tRNA transcription from RNA polymerase III promoter	DNA-directed RNA polymerase activity	DNA-directed RNA polymerase III complex
YDL147W	YDL147W	RPN5	het	Verified	-0.794109882044819	0.213565732584799	no	840	0.255856224401272	2568	NA	FT	PROTEOLYSIS	NUCLEUS		Subunit of the COP9 signalosome (CSN) and non-ATPase regulatory subunit of the 26S proteasome lid, similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p; Rpn5p is an essential protein	cullin deneddylation|ubiquitin-dependent protein catabolic process	molecular_function	proteasome complex|signalosome|proteasome storage granule|proteasome regulatory particle, lid subcomplex
YGR186W	YGR186W	TFG1	het	Verified	-0.799892165183015	0.211886638766403	no	841	0.207941284184879	2646	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RNA POL II, HOLOENZYME	TFIIF (Transcription Factor II) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74	transcription initiation from RNA polymerase II promoter|transcriptional start site selection at RNA polymerase II promoter|dephosphorylation of RNA polymerase II C-terminal domain|promoter clearance from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|regulation of protein serine/threonine phosphatase activity	core RNA polymerase II binding transcription factor activity|protein phosphatase activator activity|core RNA polymerase II recruiting transcription factor activity	transcription factor TFIIF complex
YOL010W	YOL010W	RCL1	het	Verified	-0.8000698431941	0.211835166165308	no	842	0.226579945192878	2605	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Endonuclease that cleaves pre-rRNA at site A2 for 18S rRNA biogenesis; subunit of U3-containing 90S preribosome processome complex involved in small ribosomal subunit assembly; stimulates Bms1p GTPase and U3 binding activity; similar to RNA cyclase-like proteins but no cyclase activity detected	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	RNA-3'-phosphate cyclase activity|endoribonuclease activity|enzyme activator activity	nucleolus|90S preribosome
YBL084C	YBL084C	CDC27	het	Verified	-0.800516048607424	0.211705934522057	no	843	0.22848994798458	2581	NA	FT	CELL CYCLE|CELL DIVISION|PROTEOLYSIS	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination	ubiquitin-protein ligase activity	anaphase-promoting complex
YKL165C	YKL165C	MCD4	het	Verified	-0.802341714220163	0.211177659401339	no	844	0.246161688869783	2555	NA	FF|FT	LIPID METABOLISM|CELL WALL ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes	GPI anchor biosynthetic process|ATP transport	mannose-ethanolamine phosphotransferase activity	integral to membrane|fungal-type cell wall|endoplasmic reticulum|fungal-type vacuole
YJL026W	YJL026W	RNR2	het	Verified	-0.802610457753488	0.21109996097155	no	845	0.200523875294412	2711	NA	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM	NUCLEUS		Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits	deoxyribonucleotide biosynthetic process	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	ribonucleoside-diphosphate reductase complex|nucleus|cytoplasm
YDR236C	YDR236C	FMN1	het	Verified	-0.806036407273119	0.210110928517233	no	846	0.185782989210724	2725	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	ENDOPLASMIC RETICULUM|MITOCHONDRION		Riboflavin kinase, produces riboflavin monophosphate (FMN); FMN is a necessary cofactor for many enzymes; predominantly localizes to the microsomal fraction and also found in the mitochondrial inner membrane	FMN biosynthetic process	riboflavin kinase activity|FMN adenylyltransferase activity	intracellular membrane-bounded organelle|mitochondrial inner membrane
YNL114C_d	YNL114C	YNL114C	het	Dubious	-0.808281618929012	0.209464240724579	no	847	0.235207964514587	2579	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPC19/YNL113W, an RNA polymerase subunit	Unknown	Unknown	Unknown
YER013W	YER013W	PRP22	het	Verified	-0.808621163252653	0.209366543892516	no	848	0.174953106741527	2761	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING	NUCLEUS		DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes	spliceosomal complex disassembly|generation of catalytic spliceosome for second transesterification step	second spliceosomal transesterification activity|ATP-dependent RNA helicase activity	U2-type post-spliceosomal complex|U2-type catalytic step 2 spliceosome
YMR229C	YMR229C	RRP5	het	Verified	-0.81509448258258	0.207509114805627	no	849	0.190855407858489	2750	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		RNA binding protein involved in synthesis of both 18S and 5.8S rRNAs; component of both the ribosomal small subunit (SSU) processosome and the 90S preribosome; has binding preference for single stranded tracts of U's; relocalizes from nucleolus to nucleus upon DNA replication stress	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	poly(U) RNA binding	small-subunit processome|nucleolus|90S preribosome
YPR190C	YPR190C	RPC82	het	Verified	-0.816176540080808	0.207199586233326	no	850	0.22928335434847	2671	NA	FT		NUCLEUS		RNA polymerase III subunit C82	tRNA transcription from RNA polymerase III promoter	DNA-directed RNA polymerase activity	DNA-directed RNA polymerase III complex
YGL169W	YGL169W	SUA5	het	Verified	-0.817626318948464	0.206785297239255	no	851	0.215175879751163	2638	NA	FT	RNA PROCESSING|TRANSLATION	NUCLEUS|CHROMOSOME		Single-stranded telomeric DNA-binding protein, required for normal telomere length; null mutant lacks N6-threonylcarbamoyl adenosine (t6A) modification in the anticodon loop of ANN-decoding tRNA; member of conserved YrdC/Sua5 family	threonylcarbamoyladenosine metabolic process|telomere maintenance|regulation of translational fidelity	single-stranded telomeric DNA binding	cytoplasm
YGR099W	YGR099W	TEL2	het	Verified	-0.819290066328962	0.206310469389193	no	852	0.225994116907758	2603	NA	FT	PROTEIN LOCALIZATION	NUCLEUS|CHROMOSOME		Subunit of the ASTRA complex, involved in chromatin remodeling; subunit of the telomere cap complex DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect; involved in the stability or biogenesis of PIKKs such as TORC1	protein localization to chromosome|telomere maintenance via telomerase|telomere maintenance	telomeric DNA binding	ASTRA complex|nuclear telomere cap complex
YKL028W	YKL028W	TFA1	het	Verified	-0.820110188335747	0.206076647322776	no	853	0.214245851538981	2649	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS|MITOCHONDRION	RNA POL II, HOLOENZYME	TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening	transcriptional open complex formation at RNA polymerase II promoter|transcription from RNA polymerase II promoter	single-stranded DNA binding|TFIIH-class transcription factor binding|RNA polymerase II core binding	mitochondrion|transcription factor TFIIE complex
YOR102W_d	YOR102W	YOR102W	het	Dubious	-0.824612405595514	0.204795838025246	no	854	0.207687384342319	2658	NA					Dubious open reading frame, unlikely to encode a functional protein; extensively overlaps essential OST2 gene encoding a subunit of the ER lumen oligosaccharyltransferase complex	Unknown	Unknown	Unknown
YLR076C_d	YLR076C	YLR076C	het	Dubious	-0.82874526366432	0.203624283539068	no	855	0.252565847688081	2477	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPL10 which encodes the ribosomal protein L10	Unknown	Unknown	Unknown
YDL208W	YDL208W	NHP2	het	Verified	-0.831060798940566	0.202969641855994	no	856	0.171569545348247	2775	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing	cleavage involved in rRNA processing|rRNA pseudouridine synthesis|snRNA pseudouridine synthesis	snoRNA binding	box H/ACA snoRNP complex
YBR202W	YBR202W	MCM7	het	Verified	-0.834558119478234	0.201983275437682	no	857	0.249392569237912	2527	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS|CHROMOSOME		Component of the heterohexameric MCM2-7 complex, which primes origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation in S-phase; forms an Mcm4p-6p-7p subcomplex	S phase of mitotic cell cycle|regulation of transcription from RNA polymerase II promoter|DNA replication initiation|DNA strand elongation involved in DNA replication|DNA unwinding involved in replication|pre-replicative complex assembly|double-strand break repair via break-induced replication|chromatin silencing at silent mating-type cassette|chromatin silencing at telomere	DNA replication origin binding|single-stranded DNA-dependent ATPase activity|transcription cofactor activity|single-stranded DNA binding|ATP-dependent 3'-5' DNA helicase activity|ATP binding|four-way junction helicase activity|DNA helicase activity|chromatin binding	replication fork protection complex|DNA replication preinitiation complex|nucleus|pre-replicative complex|cytoplasm|MCM complex
YOR116C	YOR116C	RPO31	het	Verified	-0.83543536088225	0.201736313581902	no	858	0.261929673675721	2505	NA	FF|FT		NUCLEUS		RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21	tRNA transcription from RNA polymerase III promoter	DNA-directed RNA polymerase activity	DNA-directed RNA polymerase III complex
YGR098C	YGR098C	ESP1	het	Verified	-0.83559454485373	0.201691519347492	no	859	0.230181884647323	2612	NA	FT	CELL CYCLE|LIPID METABOLISM|PROTEOLYSIS|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	NUCLEUS|MITOCHONDRION|CYTOSKELETON		Separase, a caspase-like cysteine protease; promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin; inhibits protein phosphatase 2A-Cdc55p to promote mitotic exit; inhibited by Pds1p; relative distribution to the nucleus increases upon DNA replication stress	regulation of exit from mitosis|regulation of mitotic spindle elongation|negative regulation of protein phosphatase type 2A activity|apoptotic process|mitotic sister chromatid segregation	cysteine-type endopeptidase activity	mitochondrion|nucleus|cytoplasm|spindle
YER126C	YER126C	NSA2	het	Verified	-0.838261063803114	0.20094204923534	no	860	0.184999761424789	2707	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Protein constituent of 66S pre-ribosomal particles, contributes to processing of the 27S pre-rRNA	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal large subunit biogenesis|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	nucleus|preribosome, large subunit precursor
YKR068C	YKR068C	BET3	het	Verified	-0.839101272386387	0.200706241078042	no	861	0.190978428799133	2711	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Hydrophilic protein that acts in conjunction with SNARE proteins in targeting and fusion of ER to Golgi transport vesicles; component of the TRAPP (transport protein particle) complex	ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport	Rab guanyl-nucleotide exchange factor activity	TRAPP complex|cis-Golgi network membrane
YDR311W	YDR311W	TFB1	het	Verified	-0.839766208744579	0.200519741627474	no	862	0.208653543233088	2681	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION	NUCLEUS	RNA POL II, HOLOENZYME	Subunit of TFIIH and nucleotide excision repair factor 3 complexes, required for nucleotide excision repair, target for transcriptional activators	phosphorylation of RNA polymerase II C-terminal domain|transcription from RNA polymerase I promoter|nucleotide-excision repair|transcription from RNA polymerase II promoter	core RNA polymerase binding transcription factor activity|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-5-phosphate binding	core TFIIH complex|holo TFIIH complex|nucleotide-excision repair factor 3 complex
YBL097W	YBL097W	BRN1	het	Verified	-0.842757392031328	0.199682070992992	no	863	0.203723799115309	2693	NA	FT	CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Subunit of the condensin complex; required for chromosome condensation and for clustering of tRNA genes at the nucleolus; may influence multiple aspects of chromosome transmission	mitotic chromosome condensation|tRNA gene clustering|mitotic sister chromatid segregation	molecular_function	nucleus|SMC loading complex|nuclear condensin complex
YDL043C	YDL043C	PRP11	het	Verified	-0.847131781971086	0.198460836008741	no	864	0.198258049349794	2717	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING	NUCLEUS		Subunit of the SF3a splicing factor complex, required for spliceosome assembly	spliceosomal complex assembly	RNA binding	U2 snRNP|U2-type prespliceosome
YPR144C	YPR144C	NOC4	het	Verified	-0.847546830127308	0.198345198072848	no	865	0.208189365307007	2691	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits	ribosomal small subunit biogenesis|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA processing	molecular_function	small-subunit processome|nucleolus|nucleus|90S preribosome|Noc4p-Nop14p complex
YNL151C	YNL151C	RPC31	het	Verified	-0.849930914083028	0.197681748527334	no	866	0.188711344842168	2746	NA	FT		NUCLEUS		RNA polymerase III subunit C31	transcription initiation from RNA polymerase III promoter|tRNA transcription from RNA polymerase III promoter	DNA-directed RNA polymerase activity	DNA-directed RNA polymerase III complex
YMR298W	YMR298W	LIP1	het	Verified	-0.855100817321168	0.196247668591039	no	867	0.175934796215874	2780	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Ceramide synthase subunit; single-span ER membrane protein associated with Lag1p and Lac1p and required for ceramide synthase activity, null mutant grows extremely slowly and is defective in ceramide synthesis	ceramide biosynthetic process	sphingosine N-acyltransferase activity	nuclear envelope|endoplasmic reticulum|endoplasmic reticulum membrane
YLR088W	YLR088W	GAA1	het	Verified	-0.856431753749644	0.195879503470615	no	868	0.191865713879621	2751	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Subunit of the GPI (glycosylphosphatidylinositol):protein transamidase complex, removes the GPI-anchoring signal and attaches GPI to proteins in the ER	attachment of GPI anchor to protein	GPI-anchor transamidase activity	integral to membrane|GPI-anchor transamidase complex
YDR437W	YDR437W	GPI19	het	Verified	-0.869152926945224	0.192381745378612	no	869	0.181396834672746	2765	NA	FT	LIPID METABOLISM|CELL WALL ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Subunit of GPI-GlcNAc transferase involved in synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), which is the first intermediate in glycosylphosphatidylinositol (GPI) anchor synthesis, shares similarity with mammalian PIG-P	GPI anchor biosynthetic process	UDP-glycosyltransferase activity	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|nuclear envelope|integral to endoplasmic reticulum membrane|endoplasmic reticulum
YJR064W	YJR064W	CCT5	het	Verified	-0.873130198611816	0.191296057723234	no	870	0.23729633127785	2580	NA					Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo	protein folding	unfolded protein binding	chaperonin-containing T-complex
YBR254C	YBR254C	TRS20	het	Verified	-0.874713191303791	0.190864990382469	no	871	0.182057993009041	2802	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOPLASMIC RETICULUM|GOLGI APPARATUS		One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; mutations in the human homolog cause the spondyloepiphyseal dysplasia tarda (SEDL) disorder	ER to Golgi vesicle-mediated transport	molecular_function	TRAPP complex
YKL095W	YKL095W	YJU2	het	Verified	-0.876532359774663	0.190370346238166	no	872	0.177257610207283	2790	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING	NUCLEUS		Essential protein required for pre-mRNA splicing; associates transiently with the spliceosomal NTC (nineteen complex) and acts after Prp2p to promote the first catalytic reaction of splicing	generation of catalytic spliceosome for first transesterification step	first spliceosomal transesterification activity	nucleus|U2-type catalytic step 1 spliceosome
YPL160W	YPL160W	CDC60	het	Verified	-0.879271040747299	0.189627166901363	no	873	0.171785810460236	2815	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION			Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA	leucyl-tRNA aminoacylation|DNA replication initiation	leucine-tRNA ligase activity	cytoplasm
YNR011C	YNR011C	PRP2	het	Verified	-0.88088370490051	0.189190384036349	no	874	0.178263137251794	2793	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING	NUCLEUS		RNA-dependent ATPase in the DEAH-box family, required for activation of the spliceosome before the first transesterification step in RNA splicing; orthologous to human protein DHX16	generation of catalytic spliceosome for first transesterification step	RNA-dependent ATPase activity	U2-type catalytic step 1 spliceosome
YER082C	YER082C	UTP7	het	Verified	-0.88524959281087	0.188011015067527	no	875	0.201312138499822	2660	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	small-subunit processome|nucleolus|90S preribosome
YDR240C	YDR240C	SNU56	het	Verified	-0.887815371191474	0.187320036600629	no	876	0.210181351094338	2682	NA	FT	RNA PROCESSING	NUCLEUS		Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart; interacts with mRNA in commitment complex	mRNA splicing, via spliceosome	mRNA binding	commitment complex|U1 snRNP|U2-type prespliceosome
YKL154W	YKL154W	SRP102	het	Verified	-0.887854782518005	0.187309435167898	no	877	0.182781463196139	2748	NA	FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors the alpha subunit, Srp101p to the ER membrane	protein targeting to ER|SRP-dependent cotranslational protein targeting to membrane	signal recognition particle binding|GTP binding|GTPase activity	integral to endoplasmic reticulum membrane|signal recognition particle receptor complex
YKL195W	YKL195W	MIA40	het	Verified	-0.891673643429664	0.186283942293232	no	878	0.218747913278088	2639	NA	FF|FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Oxidoreductase that mediates mitochondrial intermembrane space import; substrates include small proteins containing twin cysteine motifs; acts in concert with Erv1p, which oxidizes the cysteine residues of Mia40p to comprise a disulfide relay system that catalyzes import; also mediates folding of Atp23p	protein import into mitochondrial intermembrane space	molecular_function	mitochondrion|mitochondrial inner membrane|mitochondrial outer membrane translocase complex|mitochondrial intermembrane space
YGR115C_d	YGR115C	YGR115C	het	Dubious	-0.898642079351151	0.184421668772151	no	879	0.229162349340899	2606	NA	FF				Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified and essential ORF SPT6/YGR115C	Unknown	Unknown	Unknown
YJL167W	YJL167W	ERG20	het	Verified	-0.905852531269376	0.182506956057915	no	880	0.16073577662054	2831	NA	FT	LIPID METABOLISM	ENDOPLASMIC RETICULUM		Farnesyl pyrophosphate synthetase, has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis	farnesyl diphosphate biosynthetic process|ergosterol biosynthetic process|isoprenoid biosynthetic process	dimethylallyltranstransferase activity|geranyltranstransferase activity	endoplasmic reticulum|cytoplasm
YLR051C	YLR051C	FCF2	het	Verified	-0.906301037028289	0.182388268388294	no	881	0.176408819016902	2767	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Essential nucleolar protein involved in the early steps of 35S rRNA processing; interacts with Faf1p; member of a transcriptionally co-regulated set of genes called the RRB regulon	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	nucleolus|nucleus
YDR212W	YDR212W	TCP1	het	Verified	-0.908550882565155	0.181793621754786	no	882	0.215921431886338	2683	NA					Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein	protein folding	unfolded protein binding	plasma membrane|chaperonin-containing T-complex
YJL091C	YJL091C	GWT1	het	Verified	-0.909917996350626	0.181432879080347	no	883	0.167704488606239	2819	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein involved in the inositol acylation of glucosaminyl phosphatidylinositol (GlcN-PI) to form glucosaminyl(acyl)phosphatidylinositol (GlcN(acyl)PI), an intermediate in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors	GPI anchor biosynthetic process	glucosaminyl-phosphotidylinositol O-acyltransferase activity	integral to membrane|nuclear outer membrane-endoplasmic reticulum membrane network
YNR053C	YNR053C	NOG2	het	Verified	-0.92552980627722	0.177345193409278	no	884	0.195427761602996	2748	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS	NUCLEUS		Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation	ribosomal large subunit export from nucleus	GTPase activity	nucleoplasm|nucleolus|nucleus|preribosome, large subunit precursor
YPL211W	YPL211W	NIP7	het	Verified	-0.925740467142116	0.17729043610187	no	885	0.160530485928402	2835	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS	RIBOSOME	Nucleolar protein required for 60S ribosome subunit biogenesis, constituent of 66S pre-ribosomal particles; physically interacts with Nop8p and the exosome subunit Rrp43p	ribosomal large subunit assembly|ribosomal large subunit biogenesis|rRNA processing	molecular_function	cytosolic large ribosomal subunit|nucleolus|preribosome, large subunit precursor
YOR204W	YOR204W	DED1	het	Verified	-0.928158042798919	0.176662797520028	no	886	0.199571224880414	2721	NA	FT	TRANSLATION			ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, required for translation initiation of all yeast mRNAs; mutations in human DEAD-box DBY are a frequent cause of male infertility	translational initiation	RNA strand annealing activity|ATP-dependent RNA helicase activity	cytoplasm
YOR224C	YOR224C	RPB8	het	Verified	-0.929782054800086	0.176241969735746	no	887	0.258738249625387	2479	NA	FF|FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RNA POL II, HOLOENZYME	RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III	tRNA transcription from RNA polymerase III promoter|transcription from RNA polymerase I promoter|transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter	RNA-directed RNA polymerase activity|DNA-directed RNA polymerase activity	DNA-directed RNA polymerase III complex|DNA-directed RNA polymerase I complex|DNA-directed RNA polymerase II, core complex
YOR259C	YOR259C	RPT4	het	Verified	-0.934214872888505	0.175096532636675	no	888	0.230108616138562	2597	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE|PROTEOLYSIS	NUCLEUS		One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in degradation of ubiquitinated substrates; contributes preferentially to ERAD; required for spindle pole body duplication; mainly nuclear localization	ER-associated protein catabolic process|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription elongation from RNA polymerase II promoter|nucleotide-excision repair|proteasome regulatory particle assembly	ATPase activity|protein domain specific binding	proteasome regulatory particle, base subcomplex|nucleus
YOR181W	YOR181W	LAS17	het	Verified	-0.937487742592739	0.174253862958226	no	889	0.15109946816747	2855	NA	FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Actin assembly factor, activates the Arp2/3 protein complex that nucleates branched actin filaments; localizes with the Arp2/3 complex to actin patches; homolog of the human Wiskott-Aldrich syndrome protein (WASP)	bipolar cellular bud site selection|endocytosis|actin polymerization or depolymerization|actin filament organization|actin cortical patch localization|positive regulation of actin filament bundle assembly|response to osmotic stress|cytokinesis	cytoskeletal protein binding	mating projection tip|cytoplasm|actin cortical patch
YOR206W	YOR206W	NOC2	het	Verified	-0.938914907847269	0.173887217249803	no	890	0.168914529167593	2796	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS	NUCLEUS|MITOCHONDRION		Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes, as well as a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors	ribosomal subunit export from nucleus|ribosome assembly	molecular_function	mitochondrion|nucleus|Noc2p-Noc3p complex|Noc1p-Noc2p complex
YHR036W	YHR036W	BRL1	het	Verified	-0.939097764011838	0.173840276091095	no	891	0.21912580724125	2658	NA	FF|FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export	mRNA export from nucleus|protein export from nucleus|nuclear envelope organization	molecular_function	nuclear envelope|endoplasmic reticulum
YKL045W	YKL045W	PRI2	het	Verified	-0.943016284387927	0.172836286795286	no	892	0.171578794566153	2768	NA	FT	RESPONSE TO DNA DAMAGE	ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME		Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair	lagging strand elongation|DNA replication, synthesis of RNA primer|DNA synthesis involved in DNA repair|DNA replication|DNA replication initiation	single-stranded DNA binding|DNA primase activity	nuclear envelope|alpha DNA polymerase:primase complex|nucleus
YBL092W	YBL092W	RPL32	het	Verified	-0.943126112891397	0.172808200270574	no	893	0.242946016624454	2554	NA	FF|FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L32; overexpression disrupts telomeric silencing; homologous to mammalian ribosomal protein L32, no bacterial homolog	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YJL001W	YJL001W	PRE3	het	Verified	-0.948861189811686	0.171345607850285	no	894	0.192199010262125	2644	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Beta 1 subunit of the 20S proteasome, responsible for cleavage after acidic residues in peptides	proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process	endopeptidase activity	nucleus|proteasome storage granule|endoplasmic reticulum membrane|proteasome core complex, beta-subunit complex
YJL072C	YJL072C	PSF2	het	Verified	-0.952515207160836	0.170417878656807	no	895	0.184059102410273	2752	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery	double-strand break repair via break-induced replication|DNA-dependent DNA replication	molecular_function	GINS complex|replication fork protection complex|nuclear replication fork|nucleus|DNA replication preinitiation complex
YPL076W	YPL076W	GPI2	het	Verified	-0.964642149025756	0.167362040207615	no	896	0.163993036173172	2835	NA	FT	LIPID METABOLISM	ENDOPLASMIC RETICULUM		Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-C protein	GPI anchor biosynthetic process	phosphatidylinositol N-acetylglucosaminyltransferase activity	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|integral to membrane|endoplasmic reticulum
YIL068C	YIL068C	SEC6	het	Verified	-0.966511793019692	0.166894074355539	no	897	0.154405890303978	2823	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION	SITE OF POLARIZED GROWTH		Essential 88kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; anchors the assembled complex to sites of secretion; interacts with SM-like protein and SNARE regulator Sec1p and may recruit it to sites of secretion; interacts with Sec9p and inhibits formation of the t-SNARE complex between Sec9p and Sso1p	exocyst localization|Golgi to plasma membrane transport|exocytosis|vesicle fusion|negative regulation of SNARE complex assembly|vesicle docking involved in exocytosis	protein homodimerization activity	mating projection tip|cellular bud neck|cellular bud tip|exocyst
YIL048W	YIL048W	NEO1	het	Verified	-0.973559416736864	0.165137672518051	no	898	0.187843730293214	2765	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus	retrograde vesicle-mediated transport, Golgi to ER|vacuole organization|endocytosis	phospholipid-translocating ATPase activity|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	endosome|COPI-coated vesicle|integral to membrane|Golgi apparatus|Golgi membrane
YFR005C	YFR005C	SAD1	het	Verified	-0.976819480247971	0.164329265092503	no	899	0.168947106406465	2791	NA	FT	RNA PROCESSING|PROTEOLYSIS	NUCLEUS		Conserved zinc-finger domain protein involved in pre-mRNA splicing, required for assembly of U4 snRNA into the U4/U6 particle	mRNA splicing, via spliceosome	molecular_function	nucleus
YDL235C	YDL235C	YPD1	het	Verified	-0.978691618470332	0.163866187329672	no	900	0.154262192986076	2787	NA	FT	SIGNALING	NUCLEUS		Phosphorelay intermediate protein, phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus	osmosensory signaling pathway via two-component system	protein histidine kinase binding|transferase activity, transferring phosphorus-containing groups	nucleus|cytoplasm
YOR362C	YOR362C	PRE10	het	Verified	-0.980347600854337	0.163457282750315	no	901	0.205728994710903	2726	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION		Alpha 7 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress	proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process	mRNA binding	mitochondrion|proteasome core complex, alpha-subunit complex|nucleus|proteasome storage granule|nuclear outer membrane-endoplasmic reticulum membrane network
YGR073C_d	YGR073C	YGR073C	het	Dubious	-0.983991447038767	0.162559859136122	no	902	0.164776504068172	2829	NA					Dubious open reading frame unlikely to encode a functional protein, extensively overlaps essential SMD1 gene encoding a U6 snRNP protein	Unknown	Unknown	Unknown
YHR186C	YHR186C	KOG1	het	Verified	-0.986699210180284	0.161895058690665	no	903	0.154082955803221	2851	NA	FT	SIGNALING|RESPONSE TO NUTRIENT LEVELS	MITOCHONDRION|PLASMA MEMBRANE		Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors	TOR signaling cascade|regulation of cell growth|cellular response to starvation	ubiquitin binding	TORC1 complex|fungal-type vacuole membrane|mitochondrion|plasma membrane
YKR081C	YKR081C	RPF2	het	Verified	-0.989308367906094	0.161256145588827	no	904	0.185838675008579	2767	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Essential protein involved in the processing of pre-rRNA and the assembly of the 60S ribosomal subunit; interacts with ribosomal protein L11; localizes predominantly to the nucleolus; constituent of 66S pre-ribosomal particles	ribosomal large subunit assembly|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	7S RNA binding|5S rRNA binding|rRNA binding	nucleolus|preribosome, large subunit precursor
YKL004W	YKL004W	AUR1	het	Verified	-0.998782200233691	0.158950105248866	no	905	0.155661587907482	2868	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance	inositolphosphoceramide metabolic process|sphingolipid biosynthetic process	inositol phosphoceramide synthase activity	integral to membrane|Golgi apparatus|inositol phosphoceramide synthase complex
YDR235W	YDR235W	PRP42	het	Verified	-0.999988426315079	0.158658054440589	no	906	0.155638784987372	2845	NA	FT	RNA PROCESSING	NUCLEUS		U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats	mRNA splicing, via spliceosome	RNA binding	U1 snRNP|U2-type prespliceosome
YDR052C	YDR052C	DBF4	het	Verified	-1.00317850232806	0.157887371718433	no	907	0.179765353435738	2774	NA	FT	CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION|CHROMOSOME SEGREGATION			Regulatory subunit of Cdc7p-Dbf4p kinase complex; required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated; relative distribution to the nucleus increases upon DNA replication stress	negative regulation of exit from mitosis|DNA replication initiation|positive regulation of protein kinase activity	DNA replication origin binding|protein serine/threonine kinase activator activity	Dbf4-dependent protein kinase complex
YOR077W	YOR077W	RTS2	het	Verified	-1.0176076489532	0.15443222543328	no	908	0.122272235286371	2949	NA	FT		NUCLEUS		Basic zinc-finger protein, similar to human and mouse Kin17 proteins which are chromatin-associated proteins involved in UV response and DNA replication	biological_process	molecular_function	nucleus|cytoplasm
YJL005W	YJL005W	CYR1	het	Verified	-1.01821431763355	0.154288058354969	no	909	0.130975981562021	2902	NA	FT	SIGNALING|NUCLEOTIDE METABOLISM	MITOCHONDRION|PLASMA MEMBRANE		Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation	adenylate cyclase-modulating G-protein coupled receptor signaling pathway|Ras protein signal transduction	adenylate cyclase activity	mitochondrion|plasma membrane
YMR197C	YMR197C	VTI1	het	Verified	-1.03293031053156	0.150818256454694	no	910	0.139832996620748	2927	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Protein involved in cis-Golgi membrane traffic; v-SNARE that interacts with two t-SNARES, Sed5p and Pep12p; required for multiple vacuolar sorting pathways	Golgi to vacuole transport|vacuole fusion, non-autophagic|intra-Golgi vesicle-mediated transport|vesicle fusion	SNAP receptor activity	SNARE complex|integral to Golgi membrane
YGL040C	YGL040C	HEM2	het	Verified	-1.04075226812634	0.148995269055579	no	911	0.148078243471273	2879	NA	FT	COFACTOR METABOLISM	NUCLEUS		Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus	heme biosynthetic process	porphobilinogen synthase activity	nucleus|cytoplasm
YGR147C	YGR147C	NAT2	het	Verified	-1.04771495722764	0.147384977109737	no	912	0.152519282276185	2834	NA	FT		MITOCHONDRION		Protein with an apparent role in acetylation of N-terminal methionine residues	N-terminal peptidyl-methionine acetylation	molecular_function	mitochondrion
YDL105W	YDL105W	NSE4	het	Verified	-1.04885151823041	0.14712323101843	no	913	0.14641795051068	2882	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair	DNA repair	molecular_function	Smc5-Smc6 complex|nucleus
YNL188W	YNL188W	KAR1	het	Verified	-1.05672763599652	0.145317954251988	no	914	0.147465340245398	2856	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION	NUCLEUS|CYTOSKELETON		Essential protein involved in karyogamy during mating and in spindle pole body duplication during mitosis, localizes to the half-bridge of the spindle pole body, interacts with Spc72p during karyogamy, also interacts with Cdc31p	karyogamy involved in conjugation with cellular fusion|spindle pole body duplication associated with nuclear envelope	protein binding	half bridge of spindle pole body
YNL061W	YNL061W	NOP2	het	Verified	-1.06655178488385	0.143087141309621	no	915	0.157891870039986	2820	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles	rRNA processing	S-adenosylmethionine-dependent methyltransferase activity|RNA methyltransferase activity	nucleolus|preribosome, large subunit precursor
YGR265W_d	YGR265W	YGR265W	het	Dubious	-1.06738221817176	0.142899637384755	no	916	0.15003559070072	2836	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MES1/YGR264C, which encodes methionyl-tRNA synthetase	Unknown	Unknown	Unknown
YPL143W	YPL143W	RPL33A	het	Verified	-1.06951802862527	0.142418154773082	no	917	0.134085980400171	2904	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L33A; N-terminally acetylated; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33A has a paralog, RPL33B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YBR247C	YBR247C	ENP1	het	Verified	-1.07710812690676	0.140715981398213	no	918	0.138144637007024	2901	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Protein associated with U3 and U14 snoRNAs, required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA processing	snoRNA binding	preribosome, small subunit precursor|nucleolus|nucleus|cytoplasm|90S preribosome
YGL207W	YGL207W	SPT16	het	Verified	-1.07912314475186	0.140266417425897	no	919	0.14454035860894	2902	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; some mutations cause reduced nucleosome occupancy over highly transcribed regions of the yeast genome	DNA replication-independent nucleosome organization|regulation of transcription by chromatin organization|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription initiation from RNA polymerase II promoter|nucleosome assembly|transcription elongation from RNA polymerase II promoter|DNA-dependent DNA replication	chromatin binding|nucleosome binding|histone binding	nuclear chromatin|FACT complex|replication fork protection complex|alpha DNA polymerase:primase complex|transcription elongation factor complex
YBR234C	YBR234C	ARC40	het	Verified	-1.08083893202843	0.139884383554512	no	920	0.128288205779332	2944	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION	CYTOSKELETON		Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches	mitochondrion inheritance|actin nucleation|actin filament organization	ubiquitin binding	Arp2/3 protein complex
YGR048W	YGR048W	UFD1	het	Verified	-1.08381252317762	0.139223965743211	no	921	0.162937094555441	2863	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; polyubiquitin binding protein that assists in the dislocation of misfolded, ERAD substrates that are subsequently delivered to the proteasome for degradation; involved in regulated destruction of ER membrane proteins such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); involved in mobilizing membrane bound transaction factors by regulated Ub/proteasome-dependent processing (RUP)	retrograde protein transport, ER to cytosol|proteasomal ubiquitin-dependent protein catabolic process|ER-associated protein catabolic process|ER-associated misfolded protein catabolic process|Unknown|cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process	ubiquitin binding|polyubiquitin binding	nucleus|Cdc48p-Npl4p-Ufd1p AAA ATPase complex
YLR321C	YLR321C	SFH1	het	Verified	-1.08563090597878	0.138821160287044	no	922	0.195184392888284	2726	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME	RSC COMPLEX	Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog	ATP-dependent chromatin remodeling|double-strand break repair|chromosome segregation|regulation of DNA replication involved in S phase|chromatin remodeling at centromere|nucleosome disassembly|G2/M transition of mitotic cell cycle|transcription elongation from RNA polymerase II promoter	DNA translocase activity	RSC complex
YPL093W	YPL093W	NOG1	het	Verified	-1.08613448458748	0.138709748773064	no	923	0.169418866283008	2801	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Putative GTPase that associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN family of nucleolar G-proteins	ribosomal subunit export from nucleus|ribosomal large subunit biogenesis|rRNA processing	GTP binding	nucleolus|preribosome, large subunit precursor
YIL078W	YIL078W	THS1	het	Verified	-1.08648597071925	0.138632022233124	no	924	0.120764262651501	2963	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION	MITOCHONDRION		Threonyl-tRNA synthetase, essential cytoplasmic protein	cytoplasmic translation|threonyl-tRNA aminoacylation	threonine-tRNA ligase activity	mitochondrion|cytoplasm
YOR157C	YOR157C	PUP1	het	Verified	-1.08930235150098	0.138010288074619	no	925	0.169114743679628	2823	NA	FF|FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Beta 2 subunit of the 20S proteasome; endopeptidase with trypsin-like activity that cleaves after basic residues; synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z	proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process	endopeptidase activity	proteasome storage granule|nucleus|endoplasmic reticulum membrane|proteasome core complex, beta-subunit complex
YGL030W	YGL030W	RPL30	het	Verified	-1.09431081830726	0.136909341095381	no	926	0.137003064991583	2910	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L30; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript; homologous to mammalian ribosomal protein L30, no bacterial homolog	cytoplasmic translation|negative regulation of mRNA splicing, via spliceosome|negative regulation of translation|rRNA processing	structural constituent of ribosome|RNA binding|pre-mRNA 5'-splice site binding	cytosolic large ribosomal subunit|cytoplasm
YML015C	YML015C	TAF11	het	Verified	-1.09707979144777	0.136303256693531	no	927	0.140504443829566	2920	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RNA POL II, HOLOENZYME	TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors	RNA polymerase II transcriptional preinitiation complex assembly|transcription from RNA polymerase II promoter	chromatin binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly	transcription factor TFIID complex
YML093W	YML093W	UTP14	het	Verified	-1.10022527521314	0.135616990331352	no	928	0.179840017998094	2787	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	small-subunit processome|nucleolus
YPR136C_d	YPR136C	YPR136C	het	Dubious	-1.10936039331424	0.133637370645186	no	929	0.140598611947288	2872	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF RRP9	Unknown	Unknown	Unknown
YGR094W	YGR094W	VAS1	het	Verified	-1.11141073953139	0.133195795858119	no	930	0.106678347708249	3000	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION	MITOCHONDRION		Mitochondrial and cytoplasmic valyl-tRNA synthetase	valyl-tRNA aminoacylation	valine-tRNA ligase activity	mitochondrion|cytoplasm
YPL217C	YPL217C	BMS1	het	Verified	-1.11294561367419	0.132865894067231	no	931	0.152086788055515	2868	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEOTIDE METABOLISM	NUCLEUS|MITOCHONDRION		GTPase required for synthesis of 40S ribosomal subunits and for processing the 35S pre-rRNA at sites A0, A1, and A2; interacts with Rcl1p, which stimulates its GTPase and U3 snoRNA binding activities; has similarity to Tsr1p	ribosome assembly|rRNA processing	U3 snoRNA binding|GTP binding|GTPase activity	mitochondrion|nucleolus|nucleus|90S preribosome|cytoplasm
YDL193W	YDL193W	NUS1	het	Verified	-1.11363438221279	0.132718035019736	no	932	0.183407420400006	2759	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Putative prenyltransferase, required for cell viability; proposed to be involved in protein trafficking because tet-repressible mutant shows accumulation of hypoglycosylated forms of CPY	protein glycosylation	prenyltransferase activity	nuclear envelope|lipid particle|endoplasmic reticulum
YBR004C	YBR004C	GPI18	het	Verified	-1.11741859280345	0.13190769452598	no	933	0.111409317712221	3041	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		Functional ortholog of human PIG-V, which is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis; the authentic, non-tagged protein was localized to mitochondria	GPI anchor biosynthetic process	mannosyltransferase activity|dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity	integral to endoplasmic reticulum membrane|mitochondrion|mannosyltransferase complex|integral to membrane|endoplasmic reticulum
YBR136W	YBR136W	MEC1	het	Verified	-1.12191358343924	0.130949592309998	no	934	0.110163041496167	3045	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION	NUCLEUS|MITOCHONDRION		Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; regulates P-body formation induced by replication stress; monitors and participates in meiotic recombination; associates with shortened, dysfunctional telomeres	histone phosphorylation|telomere maintenance via recombination|telomere maintenance|nucleobase-containing compound metabolic process|reciprocal meiotic recombination|DNA recombination|DNA damage checkpoint|DNA replication|DNA damage induced protein phosphorylation	protein kinase activity	mitochondrion|nucleus
YFL024C	YFL024C	EPL1	het	Verified	-1.12675921891483	0.129922148528978	no	935	0.128836372851677	2946	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS	HISTONE ACETYLTRANSFERASE	Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC (nucleosome core particle); required for autophagy; homologous to Drosophila Enhancer of Polycomb	DNA repair|histone acetylation|regulation of transcription from RNA polymerase II promoter	histone acetyltransferase activity	Piccolo NuA4 histone acetyltransferase complex|NuA4 histone acetyltransferase complex
YMR227C	YMR227C	TAF7	het	Verified	-1.12919785755878	0.12940718866032	no	936	0.135629896121045	2934	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RNA POL II, HOLOENZYME	TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation	RNA polymerase II transcriptional preinitiation complex assembly|transcription from RNA polymerase II promoter	RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly	nucleus|transcription factor TFIID complex
YDR407C	YDR407C	TRS120	het	Verified	-1.13661056688759	0.127850560349987	no	937	0.121341687002089	2976	NA	FT	VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM	GOLGI APPARATUS		One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic	regulation of Rab GTPase activity|early endosome to Golgi transport|intra-Golgi vesicle-mediated transport	Rab guanyl-nucleotide exchange factor activity	trans-Golgi network|TRAPP complex|early endosome
YPR108W	YPR108W	RPN7	het	Verified	-1.14481413477149	0.126143079417954	no	938	0.165128285915333	2808	NA	FT	PROTEOLYSIS	NUCLEUS		Essential, non-ATPase regulatory subunit of the 26S proteasome, similar to another S. cerevisiae regulatory subunit, Rpn5p, as well as to mammalian proteasome subunits	ubiquitin-dependent protein catabolic process	structural molecule activity	nucleus|proteasome regulatory particle, lid subcomplex
YKL180W	YKL180W	RPL17A	het	Verified	-1.14495519386901	0.126113859226638	no	939	0.182968491388201	2768	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L17A; copurifies with the Dam1 complex (aka DASH complex); homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17A has a paralog, RPL17B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit|cytoplasm
YDL028C	YDL028C	MPS1	het	Verified	-1.15680186403905	0.123676660053734	no	940	0.129495949258611	2893	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME|CYTOSKELETON	KINETOCHORE	Dual-specificity kinase; required for spindle pole body (SPB) duplication and spindle checkpoint function; substrates include SPB proteins Spc42p, Spc110p, and Spc98p, mitotic exit network protein Mob1p, kinetochore protein Cnn1p, and checkpoint protein Mad1p	protein phosphorylation|sister chromatid biorientation|spindle assembly|spindle pole body duplication associated with nuclear envelope|mitotic cell cycle spindle assembly checkpoint	protein serine/threonine/tyrosine kinase activity|protein kinase activity	condensed nuclear chromosome kinetochore|spindle pole body
YJL086C_d	YJL086C	YJL086C	het	Dubious	-1.15950803351208	0.12312458193062	no	941	0.184461794038807	2765	NA	FF				Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL085W/EXO70 and YJL087C/TRL1	Unknown	Unknown	Unknown
YNL026W	YNL026W	SAM50	het	Verified	-1.17187507098285	0.120623608519202	no	942	0.105293431309863	2985	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Essential component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; homologous to bacterial Omp85	protein complex assembly|protein import into mitochondrial outer membrane	protein channel activity	mitochondrial outer membrane|mitochondrial sorting and assembly machinery complex|mitochondrion|integral to mitochondrial outer membrane
YIL075C	YIL075C	RPN2	het	Verified	-1.17559632192562	0.119878113011866	no	943	0.147951984410532	2914	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS	NUCLEUS		Subunit of the 26S proteasome; substrate of the N-acetyltransferase Nat1p; protein abundance increases in response to DNA replication stress	proteasome assembly|ubiquitin-dependent protein catabolic process	endopeptidase activity|protein binding, bridging	proteasome regulatory particle, base subcomplex|nucleus|proteasome storage granule
YGR120C	YGR120C	COG2	het	Verified	-1.17827032541632	0.119344427028186	no	944	0.13430170528167	2916	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments	peroxisome degradation|ER to Golgi vesicle-mediated transport|macroautophagy|intra-Golgi vesicle-mediated transport|retrograde transport, vesicle recycling within Golgi|CVT pathway	molecular_function	Golgi transport complex|extrinsic to membrane
YDR172W	YDR172W	SUP35	het	Verified	-1.17896358925879	0.119206337371503	no	945	0.141239064756752	2943	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|NUCLEOTIDE METABOLISM			Translation termination factor eRF3, has a role in mRNA deadenylation and decay; altered protein conformation creates the [PSI(+)] prion that alters translational fidelity and results in a nonsense suppressor phenotype	translational termination|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	translation release factor activity	cytosol|translation release factor complex
YFL002C	YFL002C	SPB4	het	Verified	-1.18803721732588	0.117409373629719	no	946	0.154896808729402	2900	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients	ribosomal large subunit assembly|rRNA processing	ATP-dependent RNA helicase activity	nucleolus|90S preribosome
YLR009W	YLR009W	RLP24	het	Verified	-1.19096262128852	0.116834129546808	no	947	0.17650611546531	2754	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS	NUCLEUS		Essential protein required for ribosomal large subunit biogenesis; associated with pre-60S ribosomal subunits; stimulates the ATPase activity of Afg2p, which is required for release of Rlp24p from the pre-60S particle; has similarity to Rpl24Ap and Rpl24Bp	ribosomal large subunit biogenesis	molecular_function	nucleolus|preribosome, large subunit precursor
YPL016W	YPL016W	SWI1	het	Verified	-1.19974874794824	0.115118467221771	no	948	0.141543453993455	2913	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS	NUCLEUS	RSC COMPLEX	Subunit of the SWI/SNF chromatin remodeling complex; regulates transcription by remodeling chromatin; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; can form the prion [SWI+]; human homolog ARID1A is a candidate tumor suppressor gene in breast cancer	cellular alcohol catabolic process|ATP-dependent chromatin remodeling|positive regulation of mating type switching|sucrose catabolic process|carbon catabolite activation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation|positive regulation of transcription from RNA polymerase II promoter|DNA-dependent DNA replication	RNA polymerase II activating transcription factor binding	SWI/SNF complex|nucleus
YIL144W	YIL144W	TID3	het	Verified	-1.20500087126127	0.114101482775612	no	949	0.119145620799901	2940	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME	KINETOCHORE	Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint activity, kinetochore assembly and clustering	microtubule nucleation|chromosome segregation|protein localization to kinetochore	structural constituent of cytoskeleton	Ndc80 complex|condensed nuclear chromosome kinetochore|condensed nuclear chromosome, centromeric region
YLR274W	YLR274W	MCM5	het	Verified	-1.20649881390074	0.113812608072829	no	950	0.129250870796695	2948	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS|CHROMOSOME		Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase	S phase of mitotic cell cycle|establishment of chromatin silencing|DNA replication initiation|regulation of DNA-dependent DNA replication initiation|negative regulation of chromatin silencing at telomere|pre-replicative complex assembly|double-strand break repair via break-induced replication|chromatin silencing at telomere	DNA helicase activity|chromatin binding|DNA replication origin binding|single-stranded DNA binding	replication fork protection complex|nuclear chromosome, telomeric region|DNA replication preinitiation complex|nucleus|pre-replicative complex|cytoplasm|MCM complex
YDR064W	YDR064W	RPS13	het	Verified	-1.2076591087078	0.113589206466083	no	951	0.106912758555618	2944	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S13 and bacterial S15	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome|SSU rRNA binding	cytosolic small ribosomal subunit|90S preribosome
YIL031W	YIL031W	ULP2	het	Verified	-1.21458989423498	0.112261272559649	no	952	0.129790035778239	2943	NA	FT	CELL CYCLE|PROTEOLYSIS	NUCLEUS		Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins, plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate	plasmid maintenance|protein desumoylation|chromosome condensation|mitotic cell cycle spindle assembly checkpoint	cysteine-type peptidase activity|SUMO-specific protease activity	nucleus
YIL126W	YIL126W	STH1	het	Verified	-1.21546193531748	0.112094979104314	no	953	0.158750918979558	2863	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	NUCLEUS	RSC COMPLEX	ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p	double-strand break repair|ATP-dependent chromatin remodeling|nucleosome positioning|chromosome segregation|chromatin remodeling at centromere|nucleosome disassembly|regulation of transcription, DNA-dependent|G2/M transition of mitotic cell cycle|meiosis|cytoskeleton organization|transcription elongation from RNA polymerase II promoter	histone acetyl-lysine binding|DNA translocase activity|helicase activity|DNA-dependent ATPase activity	RSC complex|nucleus
YNL207W	YNL207W	RIO2	het	Verified	-1.21607052017464	0.111979029683376	no	954	0.119665552903109	2956	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|PROTEIN PHOSPHORYLATION	NUCLEUS		Essential serine kinase involved in the processing of the 20S pre-rRNA into mature 18S rRNA; has similarity to Rio1p	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	nucleocytoplasmic transporter activity|protein kinase activity	cytosol|nucleus|cytoplasm
YPL083C	YPL083C	SEN54	het	Verified	-1.22640982116364	0.110022246009479	no	955	0.0904517372670294	3072	NA	FT	RNA PROCESSING	ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION		Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p	tRNA-type intron splice site recognition and cleavage	tRNA-intron endonuclease activity	mitochondrial outer membrane|mitochondrion|tRNA-intron endonuclease complex
YOL144W	YOL144W	NOP8	het	Verified	-1.22662818840747	0.109981184741861	no	956	0.157985563415881	2830	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS	NUCLEUS		Nucleolar protein required for 60S ribosomal subunit biogenesis	ribosomal large subunit biogenesis	molecular_function	nucleolus
YER043C	YER043C	SAH1	het	Verified	-1.23365544816935	0.108665660940853	no	957	0.0897569605249061	3080	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor	methionine metabolic process|selenocysteine metabolic process	adenosylhomocysteinase activity	cytoplasm
YFL034C-B	YFL034C-B	MOB2	het	Verified	-1.23874762555574	0.107719487670849	no	958	0.0708058126636819	3092	NA	FT	CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION	NUCLEUS|SITE OF POLARIZED GROWTH		Activator of Cbk1p kinase; component of the RAM signaling network that regulates cellular polarity and morphogenesis; activation of Cbk1p facilitates the Ace2p-dependent daughter cell-specific transcription of genes involved in cell separation; similar to Mob1p	positive regulation of protein phosphorylation|establishment or maintenance of cell polarity|Unknown|budding cell apical bud growth	protein kinase activator activity	nucleus|cellular bud|cellular bud neck|mating projection tip|cellular bud tip
YPL228W	YPL228W	CET1	het	Verified	-1.24006218606835	0.107476196995594	no	959	0.110945861412806	2961	NA	FT	RNA PROCESSING	NUCLEUS		Beta (RNA 5'-triphosphatase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CEG1, a guanylyltransferase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide	7-methylguanosine mRNA capping	polynucleotide 5'-phosphatase activity	mRNA cap methyltransferase complex|nucleus
YIL026C	YIL026C	IRR1	het	Verified	-1.24082399776721	0.107335387010444	no	960	0.12502465451006	2980	NA	FF|FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Subunit of the cohesin complex, which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms, essential for viability	spore germination|fungal-type cell wall organization|cytogamy|mitotic sister chromatid cohesion	chromatin binding	nucleus|nuclear mitotic cohesin complex
YGR024C	YGR024C	THG1	het	Verified	-1.245986505112	0.106384674776619	no	961	0.100165619753344	3012	NA	FT	RNA PROCESSING	NUCLEUS		tRNAHis guanylyltransferase, adds a guanosine residue to the 5' end of tRNAHis after transcription and RNase P cleavage; couples nuclear division and migration to cell budding and cytokinesis; essential enzyme conserved among eukaryotes	tRNA modification	tRNA guanylyltransferase activity	nucleus|cytoplasm
YDL166C	YDL166C	FAP7	het	Verified	-1.25241234898835	0.105209824410355	no	962	0.118665571956383	2942	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Essential NTPase required for small ribosome subunit synthesis, mediates processing of the 20S pre-rRNA at site D in the cytoplasm but associates only transiently with 43S preribosomes via Rps14p, may be the endonuclease for site D	cellular response to oxidative stress|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal small subunit export from nucleus	nucleoside-triphosphatase activity	nucleus|preribosome|cytoplasm
YDR113C	YDR113C	PDS1	het	Verified	-1.2554695286737	0.104654181495117	no	963	0.111127731807054	2985	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS|CYTOSKELETON		Securin, inhibits anaphase by binding separin Esp1p; blocks cyclin destruction and mitotic exit, essential for meiotic progression and mitotic cell cycle arrest; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation	protein localization|recombinational repair|meiosis I|mitotic sister chromatid segregation	enzyme binding	nucleus|cytoplasm|spindle
YJL090C	YJL090C	DPB11	het	Verified	-1.26025024758179	0.103789550789789	no	964	0.101567564287656	3030	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION	NUCLEUS|CHROMOSOME		DNA replication initiation protein; loads DNA pol epsilon onto pre-replication complexes at origins; checkpoint sensor recruited to stalled replication forks by the checkpoint clamp complex where it activates Mec1p; ortholog of human TopBP1; forms nuclear foci upon DNA replication stress	lagging strand elongation|recombinational repair|nucleotide-excision repair|DNA replication initiation|mismatch repair|positive regulation of protein phosphorylation|mating type switching|DNA replication checkpoint|double-strand break repair via break-induced replication|mitotic cell cycle G2/M transition DNA damage checkpoint|leading strand elongation	protein kinase activator activity|protein binding	DNA replication preinitiation complex|replication fork|epsilon DNA polymerase complex
YNL150W_d	YNL150W	YNL150W	het	Dubious	-1.26906956470977	0.102208127094928	no	965	0.118560889351539	2937	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; extensive overlap with PGA2/YNL149C, an uncharacterized gene with a proposed role in protein trafficking	Unknown	Unknown	Unknown
YEL035C_p	YEL035C	UTR5	het	Uncharacterized	-1.27870449625716	0.100500567882413	no	966	0.123544470503665	3010	NA					Protein of unknown function; transcription may be regulated by Gcr1p; essential for growth under standard (aerobic) conditions but not under anaerobic conditions	biological_process	molecular_function	cellular_component
YLR275W	YLR275W	SMD2	het	Verified	-1.27954927043578	0.100351850455565	no	967	0.127785023859983	2960	NA	FT	RNA PROCESSING	NUCLEUS		Core Sm protein Sm D2; part of heteroheptameric complex (with Smb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D2	mRNA splicing, via spliceosome	molecular_function	U1 snRNP|U4/U6 x U5 tri-snRNP complex|U2-type prespliceosome|U5 snRNP
YIR022W	YIR022W	SEC11	het	Verified	-1.28486699627146	0.0994193828668659	no	968	0.0899983642608375	3060	NA	FT	PROTEIN LOCALIZATION|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		18kDa catalytic subunit of the Signal Peptidase Complex (SPC; Spc1p, Spc2p, Spc3p, and Sec11p) which cleaves the signal sequence of proteins targeted to the endoplasmic reticulum	signal peptide processing|protein targeting to ER	peptidase activity	signal peptidase complex|endoplasmic reticulum
YDL220C	YDL220C	CDC13	het	Verified	-1.29660484742525	0.0973835918663245	no	969	0.0918878869291534	3024	NA	FT	CELL CYCLE|CELL DIVISION	NUCLEUS|CHROMOSOME		Single stranded DNA-binding protein found at TG1-3 telomere G-tails; regulates telomere replication through recruitment of specific sub-complexes, but the essential function is telomere capping; autophagy and proteasome are involved in Cdc13p degradation	telomere capping|telomere maintenance via telomerase|negative regulation of telomerase activity|telomere maintenance|regulation of telomere maintenance via telomerase	single-stranded telomeric DNA binding|telomerase inhibitor activity	nuclear telomere cap complex
YDR302W	YDR302W	GPI11	het	Verified	-1.30095853329088	0.0966363244109536	no	970	0.127873862235514	2900	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog	GPI anchor biosynthetic process	mannose-ethanolamine phosphotransferase activity	integral to membrane|endoplasmic reticulum|endoplasmic reticulum membrane
YOR210W	YOR210W	RPB10	het	Verified	-1.30874848217341	0.0953097815531583	no	971	0.138851077330606	2877	NA	FF|FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RNA POL II, HOLOENZYME	RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III	transcription from RNA polymerase I promoter|transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter	RNA-directed RNA polymerase activity|DNA-directed RNA polymerase activity	DNA-directed RNA polymerase I complex|DNA-directed RNA polymerase III complex|DNA-directed RNA polymerase II, core complex
YMR093W	YMR093W	UTP15	het	Verified	-1.31092864527453	0.0949409359831297	no	972	0.113497306860289	2928	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS|CHROMOSOME		Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA	positive regulation of transcription from RNA polymerase I promoter|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	snoRNA binding	small-subunit processome|rDNA heterochromatin|nucleolus|t-UTP complex|90S preribosome
YPL252C	YPL252C	YAH1	het	Verified	-1.31268217174552	0.094645033778548	no	973	0.119149944678751	2987	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin	ubiquinone biosynthetic process|iron-sulfur cluster assembly|heme a biosynthetic process	oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor	mitochondrial matrix
YOR056C	YOR056C	NOB1	het	Verified	-1.31320205013602	0.0945574366777566	no	974	0.0829563693227138	3042	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS|ENDOPLASMIC RETICULUM		Protein involved in proteasomal and 40S ribosomal subunit biogenesis; required for cleavage of the 20S pre-rRNA to generate the mature 18S rRNA; cleavage is activated by Fun12p, a GTPase and translation initiation factor; relocalizes from nucleus to nucleolus upon DNA replication stress	proteasome assembly|ribosomal small subunit biogenesis|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of SSU-rRNA	endoribonuclease activity|SSU rRNA binding	preribosome, small subunit precursor|nucleus|cytoplasm
YLR212C	YLR212C	TUB4	het	Verified	-1.31546494158202	0.0941768461647044	no	975	0.0520538403614198	3179	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION	NUCLEUS|CYTOSKELETON		Gamma-tubulin; involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body; protein abundance increases in response to DNA replication stress	microtubule nucleation|mitotic spindle organization in nucleus	structural constituent of cytoskeleton	outer plaque of spindle pole body|gamma-tubulin small complex, spindle pole body|inner plaque of spindle pole body
YDR478W	YDR478W	SNM1	het	Verified	-1.33095559578353	0.0916018110932434	no	976	0.104350109518552	3015	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP	mRNA cleavage|rRNA processing	ribonuclease MRP activity|RNA binding	ribonuclease MRP complex
YOL040C	YOL040C	RPS15	het	Verified	-1.35132657689365	0.0882954210842821	no	977	0.129684645267267	2919	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19	cytoplasmic translation|rRNA export from nucleus	structural constituent of ribosome	cytosolic small ribosomal subunit
YDL003W	YDL003W	MCD1	het	Verified	-1.35886378683399	0.0870948779702051	no	978	0.0900870898775494	3073	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS|MITOCHONDRION|CHROMOSOME		Essential alpha-kleisin subunit of the cohesin complex; required for sister chromatid cohesion in mitosis and meiosis; apoptosis induces cleavage and translocation of a C-terminal fragment to mitochondria; expression peaks in S phase	double-strand break repair|apoptotic process|response to DNA damage stimulus|mitotic chromosome condensation|establishment of mitotic sister chromatid cohesion	chromatin binding	condensed nuclear chromosome|mitochondrion|nucleus|nuclear mitotic cohesin complex
YGL145W	YGL145W	TIP20	het	Verified	-1.36112017186286	0.0867378579633016	no	979	0.0681873009399377	3077	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Peripheral membrane protein required for fusion of COPI vesicles with the ER; prohibits back-fusion of COPII vesicles with the ER; forms a tethering complex with Sec39p and Dsl1p that interacts with ER SNAREs Sec20p and Use1p	retrograde vesicle-mediated transport, Golgi to ER	molecular_function	Dsl1p complex|endoplasmic reticulum
YGL092W	YGL092W	NUP145	het	Verified	-1.37323829150298	0.08483913965759	no	980	0.107883040570854	3067	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Essential protein with distinct roles in two nuclear pore subcomplexes; catalyzes its own proteolytic cleavage in vivo to generate a C-terminal fragment that is a structural component of the Nup84p subcomplex (with roles in NPC biogenesis and localization of genes to the nuclear periphery), and an N-terminal fragment that is one of several FG-nucleoporins within the NPC central core directly responsible for nucleocytoplasmic transport; homologous to human NUP98	double-strand break repair|poly(A)+ mRNA export from nucleus|maintenance of chromatin silencing at telomere|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|tRNA export from nucleus|protein targeting to nuclear inner membrane|telomere tethering at nuclear periphery|nuclear pore distribution|positive regulation of transcription, DNA-dependent|NLS-bearing substrate import into nucleus|protein import into nucleus	nucleocytoplasmic transporter activity|RNA binding|structural constituent of nuclear pore	nuclear pore central transport channel|integral to membrane|nuclear pore|nuclear pore outer ring
YLR249W	YLR249W	YEF3	het	Verified	-1.37327829389435	0.0848329239377927	no	981	0.0728520210716625	3109	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|NUCLEOTIDE METABOLISM		RIBOSOME	Gamma subunit of translational elongation factor eEF1B; stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex; contains two ABC cassettes; binds and hydrolyzes ATP; YEF3 has a paralog, HEF3, that arose from the whole genome duplication	translational elongation|translational termination	ATPase activity|translation elongation factor activity	cytosolic ribosome|ribosome
YLR355C	YLR355C	ILV5	het	Verified	-1.37426849410236	0.0846791717729277	no	982	0.124432080631488	2966	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Bifunctional acetohydroxyacid reductoisomerase and mtDNA binding protein; involved in branched-chain amino acid biosynthesis and maintenance of wild-type mitochondrial DNA; found in mitochondrial nucleoids	mitochondrial genome maintenance|branched-chain amino acid biosynthetic process	double-stranded DNA binding|ketol-acid reductoisomerase activity	mitochondrial nucleoid|mitochondrion
YJL194W	YJL194W	CDC6	het	Verified	-1.37625773337368	0.0843709267897718	no	983	0.095035927049643	3062	NA	FT	CELL CYCLE|CELL DIVISION|GENE SILENCING	NUCLEUS|PLASMA MEMBRANE		Essential ATP-binding protein required for DNA replication; component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p; relocalizes from nucleus to cytoplasm upon DNA replication stress	regulation of DNA-dependent DNA replication initiation|regulation of chromatin silencing at telomere|pre-replicative complex assembly|G1/S transition of mitotic cell cycle	DNA replication origin binding|protein binding|chromatin binding|ATPase activity|GTP binding|GTPase activity|ATP binding	DNA replication preinitiation complex|pre-replicative complex
YHL015W	YHL015W	RPS20	het	Verified	-1.37783727878866	0.0841267667244696	no	984	0.109113513871788	2943	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit
YDL141W	YDL141W	BPL1	het	Verified	-1.38194263721804	0.0834946574467486	no	985	0.0583487490138887	3149	NA	FT		NUCLEUS		Biotin:apoprotein ligase, covalently modifies proteins with the addition of biotin, required for acetyl-CoA carboxylase (Acc1p) holoenzyme formation	protein biotinylation	biotin-[pyruvate-carboxylase] ligase activity|biotin-[acetyl-CoA-carboxylase] ligase activity	nucleus|cytoplasm
YNR054C	YNR054C	ESF2	het	Verified	-1.3841903554237	0.0831500878673655	no	986	0.064977978063483	3133	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|small-subunit processome assembly|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	ATPase activator activity|RNA binding	nucleolus|90S preribosome|cytoplasm
YGR145W	YGR145W	ENP2	het	Verified	-1.38522530297693	0.0829917929825984	no	987	0.0944810529206793	3086	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Essential nucleolar protein, required for biogenesis of the small ribosomal subunit; contains WD repeats, interacts with Mpp10p and Bfr2p, and has homology to Spb1p	ribosomal small subunit biogenesis|rRNA processing	molecular_function	nucleolus|90S preribosome
YNL258C	YNL258C	DSL1	het	Verified	-1.38788008787082	0.0825867810781977	no	988	0.0858020460644535	3064	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PEROXISOME ORGANIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Peripheral membrane protein needed for Golgi-to-ER retrograde traffic; forms a complex with Sec39p and Tip20p that interacts with ER SNAREs Sec20p and Use1p; component of the ER target site that interacts with coatomer; interacts with Cin5p; similar to the fly and human ZW10 gene	retrograde vesicle-mediated transport, Golgi to ER|ER-dependent peroxisome organization	molecular_function	Dsl1p complex|endoplasmic reticulum|peroxisome|nucleus
YER147C	YER147C	SCC4	het	Verified	-1.3904014074397	0.0822035096658807	no	989	0.102091759574677	3013	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX	double-strand break repair|establishment of protein localization to chromatin|rDNA condensation|mitotic chromosome condensation|mitotic sister chromatid cohesion	molecular_function	nuclear chromatin|SMC loading complex
YBL030C	YBL030C	PET9	het	Verified	-1.39144254153463	0.0820456359552918	no	990	0.10068041951638	3003	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Major ADP/ATP carrier of the mitochondrial inner membrane; exchanges cytosolic ADP for mitochondrially synthesized ATP; also imports heme and ATP; phosphorylated; required for viability in many lab strains that carry a sal1 mutation; PET9 has a paralog, AAC3, that arose from the whole genome duplication	heme transport|transmembrane transport|aerobic respiration|anaerobic respiration|ATP transport|ADP transport|apoptotic process|mitochondrial transport	ATP:ADP antiporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YGL201C	YGL201C	MCM6	het	Verified	-1.39373496686236	0.0816988264737933	no	991	0.0838890942531608	3098	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex; forms a subcomplex with Mcm4p and Mcm7p	S phase of mitotic cell cycle|DNA strand elongation involved in DNA replication|DNA unwinding involved in replication|double-strand break repair via break-induced replication|pre-replicative complex assembly|DNA replication initiation	four-way junction helicase activity|DNA helicase activity|DNA replication origin binding|single-stranded DNA-dependent ATPase activity|ATP-dependent 3'-5' DNA helicase activity	replication fork protection complex|DNA replication preinitiation complex|nucleus|pre-replicative complex|cytoplasm|MCM complex
YPL020C	YPL020C	ULP1	het	Verified	-1.39996359641435	0.0807621099892872	no	992	0.108527712124626	3003	NA	FT	CELL CYCLE|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Protease that specifically cleaves Smt3p protein conjugates; required for cell cycle progression; associates with nucleoporins and may interact with septin rings during telophase; sequestered to the nucleolus under stress conditions	G2/M transition of mitotic cell cycle|protein desumoylation	cysteine-type peptidase activity|SUMO-specific protease activity	nuclear envelope|nucleolus|nuclear pore
YGL068W	YGL068W	MNP1	het	Verified	-1.40694670258941	0.0797215967536521	no	993	0.0749542484434617	3099	NA	FT	TRANSLATION|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Protein associated with the mitochondrial nucleoid; putative mitochondrial ribosomal protein with similarity to E. coli L7/L12 ribosomal protein; required for normal respiratory growth	aerobic respiration	structural constituent of ribosome	mitochondrial nucleoid|mitochondrion
YGR156W	YGR156W	PTI1	het	Verified	-1.41484422999321	0.078557086335885	no	994	0.0764656893002264	3102	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64	termination of RNA polymerase II transcription, exosome-dependent|mRNA cleavage|termination of RNA polymerase II transcription, poly(A)-coupled|mRNA polyadenylation|snoRNA 3'-end processing	RNA binding	mRNA cleavage and polyadenylation specificity factor complex|nucleus
YJL081C	YJL081C	ARP4	het	Verified	-1.4186440771618	0.0780014043290463	no	995	0.134520957059668	2960	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME	HISTONE ACETYLTRANSFERASE	Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes	DNA repair|histone acetylation|kinetochore assembly|chromatin organization|regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|chromatin remodeling	chromatin binding|histone acetyltransferase activity|ATP-dependent 3'-5' DNA helicase activity	nuclear chromatin|Swr1 complex|nucleus|Ino80 complex|NuA4 histone acetyltransferase complex
YLR086W	YLR086W	SMC4	het	Verified	-1.41999878790071	0.0778040169648773	no	996	0.0934020259014282	3014	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Subunit of the condensin complex; reorganizes chromosomes during cell division; forms a complex with Smc2p that has ATP-hydrolyzing and DNA-binding activity; required for tRNA gene clustering at the nucleolus; potential Cdc28p substrate	mitotic chromosome condensation|mitotic sister chromatid segregation|tRNA gene clustering	chromatin binding|ATPase activity	SMC loading complex|nuclear condensin complex
YGL075C	YGL075C	MPS2	het	Verified	-1.42393870014943	0.0772321088709823	no	997	0.0831159569996473	3106	NA	FT	CELL CYCLE|CYTOSKELETON ORGANIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON		Essential membrane protein localized at the nuclear envelope and spindle pole body (SPB), required for insertion of the newly duplicated SPB into the nuclear envelope; potentially phosphorylated by Cdc28p	mitotic anaphase|spindle pole body duplication associated with nuclear envelope	structural constituent of cytoskeleton	nuclear envelope|spindle pole body
YBR011C	YBR011C	IPP1	het	Verified	-1.42773803916278	0.0766836364779751	no	998	0.101984348168781	3002	NA					Cytoplasmic inorganic pyrophosphatase (PPase), homodimer that catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase	phosphate-containing compound metabolic process	inorganic diphosphatase activity|protein homodimerization activity	cytosol
YMR268C	YMR268C	PRP24	het	Verified	-1.43884140343864	0.0750977313224745	no	999	0.108325992962227	3040	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING	NUCLEUS		Splicing factor that reanneals U4 and U6 snRNPs during spliceosome recycling	assembly of spliceosomal tri-snRNP|spliceosomal complex assembly	U6 snRNA binding|snRNA binding	U6 snRNP
YOR048C	YOR048C	RAT1	het	Verified	-1.44351963042488	0.0744370733438202	no	1000	0.103096887215331	2996	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS|MITOCHONDRION		Nuclear 5' to 3' single-stranded RNA exonuclease, involved in RNA metabolism, including rRNA and snRNA processing as well as poly (A+) dependent and independent mRNA transcription termination	termination of RNA polymerase II transcription, exosome-dependent|nuclear mRNA surveillance|termination of RNA polymerase II transcription, poly(A)-coupled|rRNA processing|RNA processing	5'-3' exoribonuclease activity	mitochondrion|nucleus
YMR061W	YMR061W	RNA14	het	Verified	-1.45133115775296	0.0733438345941933	no	1001	0.0870854701028784	3062	NA	FT	RNA PROCESSING	NUCLEUS|MITOCHONDRION		Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; bridges interaction between Rna15p and Hrp1p in the CF I complex; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping	mRNA cleavage|mRNA polyadenylation	RNA binding|protein heterodimerization activity	mRNA cleavage factor complex|mitochondrion|nucleus
YIL142W	YIL142W	CCT2	het	Verified	-1.45660120919627	0.0726132468584637	no	1002	0.085744792607907	3053	NA					Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo	protein folding	unfolded protein binding	chaperonin-containing T-complex|cytoplasm
YOR176W	YOR176W	HEM15	het	Verified	-1.46101107595963	0.0720062009283042	no	1003	0.0693452056957207	3089	NA	FT	COFACTOR METABOLISM	MITOCHONDRION		Ferrochelatase, a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway	heme biosynthetic process	ferrochelatase activity	mitochondrion|mitochondrial inner membrane
YJR007W	YJR007W	SUI2	het	Verified	-1.4888121250153	0.0682684242742039	no	1004	0.132017723916801	2911	NA	FF|FT	TRANSLATION		RIBOSOME	Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress	translational initiation	translation initiation factor activity	ribosome|multi-eIF complex|eukaryotic translation initiation factor 2 complex|cytoplasm
YOR217W	YOR217W	RFC1	het	Verified	-1.50485361969377	0.0661808573724086	no	1005	0.0793600311774052	3116	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION	NUCLEUS|CHROMOSOME		Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon	DNA repair|mismatch repair|mitotic cell cycle|leading strand elongation	DNA clamp loader activity	DNA replication factor C complex
YPR086W	YPR086W	SUA7	het	Verified	-1.50705334619722	0.0658984919401717	no	1006	0.0640030518621212	3098	NA	FT	TRANSCRIPTION FROM RNA POL II|TRANSLATION	NUCLEUS		Transcription factor TFIIB, a general transcription factor required for transcription initiation and start site selection by RNA polymerase II	transcriptional start site selection at RNA polymerase II promoter|transcriptional open complex formation at RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|Unknown	TBP-class protein binding|RNA polymerase II core binding|TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly|core RNA polymerase II recruiting transcription factor activity	nucleus
YGR065C	YGR065C	VHT1	het	Verified	-1.51203003387964	0.0652631111084441	no	1007	0.0576571063882071	3167	NA	FT		PLASMA MEMBRANE		High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin	biotin transport	biotin transporter activity	integral to membrane|plasma membrane
YDL108W	YDL108W	KIN28	het	Verified	-1.51410258742288	0.0649999112690826	no	1008	0.0581278689356357	3169	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION	NUCLEUS	RNA POL II, HOLOENZYME	Serine/threonine protein kinase, subunit of the transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promoters	phosphorylation of RNA polymerase II C-terminal domain|transcription from RNA polymerase I promoter|protein phosphorylation|transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	core RNA polymerase binding transcription factor activity|RNA polymerase II carboxy-terminal domain kinase activity|cyclin-dependent protein kinase activating kinase activity|protein kinase activity	TFIIK complex|holo TFIIH complex
YPR137W	YPR137W	RRP9	het	Verified	-1.51679997465565	0.0646585967282771	no	1009	0.0956483467027854	2987	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein	rRNA modification|rRNA processing	snoRNA binding	box C/D snoRNP complex|small-subunit processome|nucleolus|90S preribosome
YPL238C_d	YPL238C	YPL238C	het	Dubious	-1.52273642737939	0.0639123302492266	no	1010	0.125891552941878	2934	NA	FF				Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified essential gene SUI3/YPL237W	Unknown	Unknown	Unknown
YOR257W	YOR257W	CDC31	het	Verified	-1.52525294232102	0.0635980100592312	no	1011	0.106258066693232	3058	NA	FF|FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|PROTEOLYSIS|CYTOSKELETON ORGANIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON	NUCLEAR PORE	Calcium-binding component of the spindle pole body (SPB) half-bridge, required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation	microtubule nucleation|proteasomal ubiquitin-dependent protein catabolic process|spindle pole body duplication associated with nuclear envelope	structural constituent of cytoskeleton	integral to membrane|transcription export complex 2|nucleotide-excision repair factor 2 complex|half bridge of spindle pole body|nuclear pore
YOR353C	YOR353C	SOG2	het	Verified	-1.52613031764421	0.0634887065066273	no	1012	0.0559491172265082	3139	NA	FT	CELL CYCLE|SIGNALING|CELL DIVISION	SITE OF POLARIZED GROWTH		Key component of the RAM signaling network, required for proper cell morphogenesis and cell separation after mitosis	signal transduction|cytokinetic cell separation|budding cell apical bud growth	molecular_function	incipient cellular bud site|cellular bud|mating projection tip|cytoplasm
YLR424W	YLR424W	SPP382	het	Verified	-1.5327498359762	0.0626687524384285	no	1013	0.0784369987413792	3093	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING	NUCLEUS|MITOCHONDRION		Essential protein that forms a dimer with Ntr2p; also forms a trimer, with Ntr2p and Prp43p, that is involved in spliceosome disassembly; found also in a multisubunit complex with the splicing factor Clf1p; suppressor of prp38-1 mutation	spliceosomal complex disassembly|mRNA splicing, via spliceosome|generation of catalytic spliceosome for first transesterification step	RNA binding|ATP-dependent RNA helicase activity	mitochondrion|U2-type post-mRNA release spliceosomal complex|nucleus|spliceosomal complex|cytoplasm
YDL143W	YDL143W	CCT4	het	Verified	-1.53663242856143	0.0621916733486229	no	1014	0.123132583628131	2959	NA	FF				Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo	protein folding	unfolded protein binding	chaperonin-containing T-complex
YPR082C	YPR082C	DIB1	het	Verified	-1.53895936421684	0.0619071084970576	no	1015	0.0622055857355675	3113	NA	FT	CELL CYCLE|RNA PROCESSING|CELL DIVISION	NUCLEUS		17-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing, orthologue of hDIM1, the human U5-specific 15-kDa protein	mRNA splicing, via spliceosome	molecular_function	U4/U6 x U5 tri-snRNP complex|U5 snRNP
YPR085C	YPR085C	ASA1	het	Verified	-1.5392995502298	0.0618655918576991	no	1016	0.0853838877979129	3087	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1	biological_process	molecular_function	ASTRA complex
YDR187C_d	YDR187C	YDR187C	het	Dubious	-1.54173982572417	0.0615684149612497	no	1017	0.0833288304136515	3073	NA	FF				Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF CCT6/YDR188W	Unknown	Unknown	Unknown
YPR181C	YPR181C	SEC23	het	Verified	-1.54337679790691	0.061369689926853	no	1018	0.12533984445996	2982	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		GTPase-activating protein, stimulates the GTPase activity of Sar1p; component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, involved in ER to Golgi transport; substrate of Ubp3/Bre5 complex; ubiquitylated by Ub-ligase Rsp5p; proteasome-mediated degradation of Sec23p is regulated by Cdc48p	regulation of COPII vesicle coating	GTPase activator activity	COPII vesicle coat
YDL209C	YDL209C	CWC2	het	Verified	-1.55216084053669	0.0603118716765841	no	1019	0.0864062425046421	3057	NA	FT	CELL CYCLE|RNA PROCESSING	NUCLEUS		Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; binds directly to U6 snRNA; similar to S. pombe Cwf2	mRNA cis splicing, via spliceosome|mRNA splicing, via spliceosome|spliceosomal snRNP assembly	pre-mRNA binding|first spliceosomal transesterification activity|U6 snRNA binding|second spliceosomal transesterification activity	Prp19 complex|U2-type catalytic step 1 spliceosome|U2-type catalytic step 2 spliceosome
YPR034W	YPR034W	ARP7	het	Verified	-1.55257651687518	0.0602621697277344	no	1020	0.14501112421994	2914	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS	RSC COMPLEX	Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation	nucleosome mobilization|ATP-dependent chromatin remodeling|chromatin organization|nucleosome disassembly|transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	DNA translocase activity	RSC complex|SWI/SNF complex|nucleus
YIL061C	YIL061C	SNP1	het	Verified	-1.55612263267571	0.0598394670462841	no	1021	0.0659586446291581	3124	NA	FT	RNA PROCESSING	NUCLEUS		Component of U1 snRNP required for mRNA splicing via spliceosome; substrate of the arginine methyltransferase Hmt1p; may interact with poly(A) polymerase to regulate polyadenylation; homolog of human U1 70K protein; protein abundance increases in response to DNA replication stress	mRNA splicing, via spliceosome	mRNA binding|U1 snRNA binding	commitment complex|U1 snRNP|U2-type prespliceosome
YOL069W	YOL069W	NUF2	het	Verified	-1.55856219365252	0.0595500185142667	no	1022	0.0627924014685447	3128	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME|CYTOSKELETON	KINETOCHORE	Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering	microtubule nucleation|chromosome segregation	structural constituent of cytoskeleton	spindle microtubule|Ndc80 complex|condensed nuclear chromosome kinetochore|condensed nuclear chromosome, centromeric region|spindle pole body
YDR081C	YDR081C	PDC2	het	Verified	-1.57619240913999	0.0574907336930508	no	1023	0.110095033213459	3018	NA	FT	TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Transcription factor for thiamine-regulated genes; required for expression of the two isoforms of pyruvate decarboxylase (PDC1 and PDC5) along with thiamine biosynthetic genes; binds a DNA sequence in the PDC5 promoter; mutant fails to grow on 2% glucose and thus is scored as inviable under standard conditions	positive regulation of thiamine biosynthetic process|Unknown|positive regulation of transcription from RNA polymerase II promoter	transcription regulatory region sequence-specific DNA binding	nucleus
YGR114C_d	YGR114C	YGR114C	het	Dubious	-1.5831893390278	0.056689157818865	no	1024	0.122642509241527	2939	NA	FF				Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps 5' end of the essential gene SPT6	Unknown	Unknown	Unknown
YHR083W	YHR083W	SAM35	het	Verified	-1.58430632562694	0.0565620135078182	no	1025	0.0642953048327923	3113	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Essential component of the sorting and assembly machinery (SAM complex or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their insertion into the outer membrane	mitochondrial outer membrane translocase complex assembly|protein import into mitochondrial outer membrane	molecular_function	mitochondrial outer membrane|mitochondrial sorting and assembly machinery complex|mitochondrion
YNL221C	YNL221C	POP1	het	Verified	-1.59829182901189	0.0549890225151673	no	1026	0.0524483960058487	3165	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P	tRNA processing|intronic box C/D snoRNA processing|mRNA cleavage|rRNA processing	ribonuclease MRP activity|ribonuclease P activity	nucleolar ribonuclease P complex|ribonuclease MRP complex
YDR002W	YDR002W	YRB1	het	Verified	-1.61181485290092	0.0535011175466861	no	1027	0.0655522653073834	3122	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|PROTEOLYSIS|RNA LOCALIZATION	NUCLEUS		Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1	RNA export from nucleus|protein import into nucleus|G1/S transition of mitotic cell cycle|ubiquitin-dependent protein catabolic process	Ran GTPase binding	nucleus|cytoplasm
YDR489W	YDR489W	SLD5	het	Verified	-1.61230883337915	0.0534473760319775	no	1028	0.0582803201736996	3160	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery	double-strand break repair via break-induced replication|DNA-dependent DNA replication	molecular_function	GINS complex|replication fork protection complex|DNA replication preinitiation complex
YOR254C	YOR254C	SEC63	het	Verified	-1.61453175995905	0.053206066818168	no	1029	0.0456715543576249	3184	NA	FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION		Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER	posttranslational protein targeting to membrane, translocation|cytosol to ER transport|SRP-dependent cotranslational protein targeting to membrane|posttranslational protein targeting to membrane	protein transporter activity	mitochondrion|integral to membrane|Sec62/Sec63 complex|endoplasmic reticulum membrane
YEL032W	YEL032W	MCM3	het	Verified	-1.61547974307239	0.0531034218187438	no	1030	0.0702503278360512	3166	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS|CHROMOSOME		Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex	S phase of mitotic cell cycle|DNA strand elongation involved in DNA replication|double-strand break repair via break-induced replication|DNA replication initiation|pre-replicative complex assembly|chromatin silencing at telomere|chromatin silencing at silent mating-type cassette	DNA helicase activity|chromatin binding|DNA replication origin binding|ATPase activity	replication fork protection complex|DNA replication preinitiation complex|pre-replicative complex|nucleus|cytoplasm|MCM complex
YGR191W	YGR191W	HIP1	het	Verified	-1.61767136599389	0.0528667200151291	no	1031	0.073589552209467	3096	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		High-affinity histidine permease, also involved in the transport of manganese ions	manganese ion transport|histidine transport	high affinity L-histidine transmembrane transporter activity	integral to membrane|plasma membrane
YDR303C	YDR303C	RSC3	het	Verified	-1.6261282406527	0.0519611887557452	no	1032	0.0612010051837777	3112	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION	NUCLEUS	RSC COMPLEX	Component of the RSC chromatin remodeling complex; essential gene required for maintenance of proper ploidy and regulation of ribosomal protein genes and the cell wall/stress response; highly similar to Rsc30p	nucleosome positioning|ATP-dependent chromatin remodeling|regulation of cell cycle|nucleosome disassembly|regulation of DNA replication involved in S phase|regulation of transcription, DNA-dependent|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|transcription elongation from RNA polymerase II promoter	sequence-specific DNA binding|DNA translocase activity|DNA binding	RSC complex|nucleus
YMR309C	YMR309C	NIP1	het	Verified	-1.6280330918226	0.0517589345951836	no	1033	0.0834267506282852	3073	NA	FT	TRANSLATION			eIF3c subunit of the eukaryotic translation initiation factor 3 (eIF3), involved in the assembly of preinitiation complex and start codon selection	translational initiation	translation initiation factor activity	multi-eIF complex|eukaryotic translation initiation factor 3 complex|cytoplasmic stress granule|cytoplasm
YJR042W	YJR042W	NUP85	het	Verified	-1.63568147033899	0.0509531347562435	no	1034	0.0785969191698469	3111	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RIBOSOME BIOGENESIS|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP85 aka NUP75	positive regulation of transcription, DNA-dependent|mRNA export from nucleus|ribosomal large subunit export from nucleus|protein import into nucleus|nuclear pore distribution	structural constituent of nuclear pore	integral to membrane|nuclear pore|nuclear pore outer ring
YPR187W	YPR187W	RPO26	het	Verified	-1.65425937536893	0.0490374117015092	no	1035	0.0942708865829738	3002	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RNA POL II, HOLOENZYME	RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit	tRNA transcription from RNA polymerase III promoter|transcription from RNA polymerase I promoter|transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter	RNA-directed RNA polymerase activity|DNA-directed RNA polymerase activity	DNA-directed RNA polymerase III complex|DNA-directed RNA polymerase I complex|DNA-directed RNA polymerase II, core complex
YMR146C	YMR146C	TIF34	het	Verified	-1.6596887293841	0.0484885439374362	no	1036	0.104352610318676	2999	NA	FT	TRANSLATION			eIF3i subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates rate of ribosomal scanning during translation reinitiation	translation reinitiation|translational initiation	translation initiation factor activity	multi-eIF complex|eukaryotic translation initiation factor 3 complex
YDR394W	YDR394W	RPT3	het	Verified	-1.66046028064351	0.048410945992809	no	1037	0.0831712433340001	3112	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS	NUCLEUS		One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|proteasome regulatory particle assembly|ubiquitin-dependent protein catabolic process	ATPase activity	proteasome regulatory particle, base subcomplex
YKR037C	YKR037C	SPC34	het	Verified	-1.66909433461105	0.0475493429530395	no	1038	0.0564596696269423	3131	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME|CYTOSKELETON	KINETOCHORE	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body	microtubule nucleation|mitotic spindle organization in nucleus|regulation of microtubule polymerization or depolymerization	microtubule binding|structural constituent of cytoskeleton	spindle microtubule|DASH complex|condensed nuclear chromosome kinetochore|spindle pole body|spindle
YDR449C	YDR449C	UTP6	het	Verified	-1.71371258591751	0.0432907621347804	no	1039	0.0834288342896864	3039	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	snoRNA binding	small-subunit processome|nucleolus|Pwp2p-containing subcomplex of 90S preribosome|90S preribosome
YDL132W	YDL132W	CDC53	het	Verified	-1.71864323002049	0.0428396774740996	no	1040	0.0615469333118643	3138	NA	FT	CELL CYCLE|CELL DIVISION|PROTEOLYSIS	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Cullin, structural protein of SCF complexes (which also contain Skp1p, Cdc34p, Hrt1p and an F-box protein) involved in ubiquitination; SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|G2/M transition of mitotic cell cycle|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|G1/S transition of mitotic cell cycle	ubiquitin-protein ligase activity|DNA replication origin binding|protein binding, bridging	SCF ubiquitin ligase complex
YKR022C	YKR022C	NTR2	het	Verified	-1.74794777788506	0.0402365352879152	no	1041	0.0377648100830791	3243	NA	FT	RNA PROCESSING	NUCLEUS|ENDOPLASMIC RETICULUM		Essential protein that forms a dimer with Ntr1p; also forms a trimer, with Ntr2p and the DExD/H-box RNA helicase Prp43p, that is involved in spliceosome disassembly	spliceosomal complex disassembly|mRNA splicing, via spliceosome	molecular_function	endoplasmic reticulum|U2-type post-mRNA release spliceosomal complex|nucleus|spliceosomal complex|cytoplasm
YJR046W	YJR046W	TAH11	het	Verified	-1.75611129887401	0.0395347031114372	no	1042	0.0440074187891691	3209	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION	NUCLEUS		DNA replication licensing factor, required for pre-replication complex assembly	regulation of DNA-dependent DNA replication initiation|double-strand break repair via break-induced replication|pre-replicative complex assembly	DNA replication origin binding|ATP binding	pre-replicative complex|nucleus|cytoplasm
YOR249C	YOR249C	APC5	het	Verified	-1.75888061019471	0.0392988946039411	no	1043	0.0414723068734803	3172	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION|PROTEOLYSIS	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to nuclear foci decreases upon DNA replication stress	chromatin assembly|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination	ubiquitin-protein ligase activity	anaphase-promoting complex
YLR075W	YLR075W	RPL10	het	Verified	-1.78287656704658	0.0373031991755192	no	1044	0.0841655247360236	3087	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L10; responsible for joining the 40S and 60S subunits; regulates translation initiation; similar to members of the QM gene family; homologous to mammalian ribosomal protein L10 and bacterial L16; protein abundance increases in response to DNA replication stress; mutations in the human ortholog are associated with development of T-cell acute lymphoblastic leukemia and similar changes in the yeast gene result in ribosome biogenesis defects	cytoplasmic translation|translational termination|ribosomal large subunit assembly	structural constituent of ribosome	cytosolic large ribosomal subunit
YKR062W	YKR062W	TFA2	het	Verified	-1.78971496021707	0.0367498730732215	no	1045	0.0446587827415816	3197	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RNA POL II, HOLOENZYME	TFIIE small subunit, involved in RNA polymerase II transcription initiation	transcription from RNA polymerase II promoter	single-stranded DNA binding|RNA polymerase II core binding|TFIIH-class transcription factor binding	transcription factor TFIIE complex
YLR197W	YLR197W	NOP56	het	Verified	-1.80975224950729	0.0351671079425967	no	1046	0.106850854164589	2990	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects	rRNA modification|rRNA processing	molecular_function	box C/D snoRNP complex|small-subunit processome|nucleolus|nucleus|90S preribosome
YOL120C	YOL120C	RPL18A	het	Verified	-1.81358392980221	0.034870903193653	no	1047	0.0680203367472003	3096	NA	FF|FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YFR037C	YFR037C	RSC8	het	Verified	-1.81485879493285	0.0347728061021111	no	1048	0.137501053393296	3005	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS	RSC COMPLEX	Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters	ATP-dependent chromatin remodeling|double-strand break repair via nonhomologous end joining|nucleosome disassembly|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|G1/S transition of mitotic cell cycle	DNA translocase activity|DNA binding	RSC complex|nucleus
YOR372C	YOR372C	NDD1	het	Verified	-1.82940734505779	0.0336693040493598	no	1049	0.0335039497129655	3207	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE	NUCLEUS		Transcriptional activator essential for nuclear division; localized to the nucleus; essential component of the mechanism that activates the expression of a set of late-S-phase-specific genes	positive regulation of transcription involved in G2/M-phase of mitotic cell cycle	transcription coactivator activity	nucleus
YPR133C	YPR133C	SPN1	het	Verified	-1.84716978120944	0.0323612687727692	no	1050	0.0699047721044743	3065	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RNA LOCALIZATION	NUCLEUS		Protein involved in RNA polymerase II transcription; interacts genetically or physically with RNAP II, TBP, TFIIS, and chromatin remodelling factors; central domain highly conserved throughout eukaryotes; mutations confer an Spt- phenotype	poly(A)+ mRNA export from nucleus|regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription by chromatin organization|regulation of transcription from RNA polymerase II promoter	core RNA polymerase II binding transcription factor activity|RNA polymerase II transcription factor binding transcription factor activity	nucleus
YOR151C	YOR151C	RPB2	het	Verified	-1.87464209558242	0.0304209889390869	no	1051	0.0440991565385357	3222	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS|MITOCHONDRION	RNA POL II, HOLOENZYME	RNA polymerase II second largest subunit B150, part of central core; similar to bacterial beta subunit	transcription from RNA polymerase II promoter	RNA-directed RNA polymerase activity|DNA-directed RNA polymerase activity	mitochondrion|DNA-directed RNA polymerase II, core complex
YER025W	YER025W	GCD11	het	Verified	-1.87901954676938	0.0301209121431524	no	1052	0.0560502955752048	3139	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM		RIBOSOME	Gamma subunit of the translation initiation factor eIF2, involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met	positive regulation of translational fidelity	GTP binding|tRNA binding|translation initiation factor activity	multi-eIF complex|ribosome|eukaryotic translation initiation factor 2 complex
YKL125W	YKL125W	RRN3	het	Verified	-1.89602030316333	0.0289786799276513	no	1053	0.0343282679206581	3251	NA	FT		NUCLEUS		Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNA; structure reveals unique HEAT repeat fold and a surface serine patch; phosphorylation of serine patch impairs cell growth and reduces RNA polymerase I binding in vitro and RNA polymerase I recruitment to the rDNA gene in vivo	transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript	core RNA polymerase I binding transcription factor activity|RNA polymerase I transcription factor binding transcription factor activity|RNA polymerase I transcription factor binding|RNA polymerase I core binding	nucleolus
YDL152W_d	YDL152W	YDL152W	het	Dubious	-1.95045002810068	0.0255612519944187	no	1054	0.0787354061150209	3076	NA	FF				Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SAS10/YDL153C, a component of the small ribosomal subunit processosome	Unknown	Unknown	Unknown
YOL133W	YOL133W	HRT1	het	Verified	-1.9751891319258	0.0241233443970721	no	1055	0.0226674962796546	3272	NA	FT	CELL CYCLE|PROTEOLYSIS	NUCLEUS	UBIQUITIN LIGASE COMPLEX	RING finger containing subunit of Skp1-Cullin-F-box ubiquitin protein ligases (SCF); required for Gic2p, Far1p, Sic1p and Cln2p degradation; may tether Cdc34p (a ubiquitin conjugating enzyme or E2) and Cdc53p (a cullin) subunits of SCF	G2/M transition of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|G1/S transition of mitotic cell cycle	ubiquitin-protein ligase activity	SCF ubiquitin ligase complex|nucleus|cytoplasm
YJL009W_d	YJL009W	YJL009W	het	Dubious	-1.97810905209442	0.0239582028052036	no	1056	0.0506458179021928	3162	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex	Unknown	Unknown	Unknown
YNL039W	YNL039W	BDP1	het	Verified	-1.98698167030147	0.0234622140617475	no	1057	0.0254346867237014	3274	NA	FT		NUCLEUS		Essential subunit of RNA polymerase III transcription factor (TFIIIB), which is involved in transcription of genes encoding tRNAs, 5S rRNA, U6 snRNA, and other small RNAs	DNA-dependent transcriptional open complex formation|positive regulation of transposon integration|RNA polymerase III transcriptional preinitiation complex assembly	TFIIIC-class transcription factor binding|TFIIIB-type transcription factor activity	transcription factor TFIIIB complex
YGR095C	YGR095C	RRP46	het	Verified	-1.98941034962236	0.0233279641058653	no	1058	0.040840415273564	3179	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5)	nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear polyadenylation-dependent mRNA catabolic process|nonfunctional rRNA decay|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|polyadenylation-dependent snoRNA 3'-end processing|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|nuclear-transcribed mRNA catabolic process, non-stop decay|ncRNA 3'-end processing	molecular_function	nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)
YOR282W_d	YOR282W	YOR282W	het	Dubious	-1.99373755001073	0.0230903717457323	no	1059	0.0171531221288171	3272	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C	Unknown	Unknown	Unknown
YNL178W	YNL178W	RPS3	het	Verified	-2.01309788095352	0.022052166563125	no	1060	0.0468451303856872	3118	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; homologous to mammalian ribosomal protein S3 and bacterial S3	cytoplasmic translation|rRNA export from nucleus	structural constituent of ribosome|DNA-(apurinic or apyrimidinic site) lyase activity	preribosome, small subunit precursor|cytosolic small ribosomal subunit|90S preribosome
YDR188W	YDR188W	CCT6	het	Verified	-2.01935454299312	0.0217251913069815	no	1061	0.073967340122217	3058	NA					Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif	protein folding	unfolded protein binding	chaperonin-containing T-complex
YBR190W_d	YBR190W	YBR190W	het	Dubious	-2.01986060782226	0.0216989241624141	no	1062	0.0377344712630376	3184	NA					Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified ribosomal protein gene RPL21A/YBR191W	Unknown	Unknown	Unknown
YPR180W	YPR180W	AOS1	het	Verified	-2.02960557302415	0.0211983239874723	no	1063	0.0203192957067916	3238	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability	protein sumoylation	SUMO activating enzyme activity	nucleus|SUMO activating enzyme complex
YOR373W	YOR373W	NUD1	het	Verified	-2.08267387048049	0.0186404803741951	no	1064	0.0208755252430966	3257	NA	FT	CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION	ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON		Component of the spindle pole body outer plaque; acts through the mitotic exit network to specify asymmetric spindle pole body inheritance	meiotic chromosome segregation|spindle pole body separation|exit from mitosis|establishment of spindle localization	structural constituent of cytoskeleton	spindle pole body
YJR123W	YJR123W	RPS5	het	Verified	-2.12305438591371	0.0168746473670898	no	1065	0.0275661883450793	3251	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; least basic of non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; homologous to mammalian ribosomal protein S5 and bacterial S7	cytoplasmic translation|rRNA export from nucleus|regulation of translational fidelity	structural constituent of ribosome	cytosolic small ribosomal subunit|90S preribosome
YML127W	YML127W	RSC9	het	Verified	-2.1263094797221	0.0167387496212006	no	1066	0.125810687738727	3043	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION	NUCLEUS	RSC COMPLEX	Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway	G2/M transition of mitotic cell cycle|ATP-dependent chromatin remodeling|nucleosome disassembly|rRNA transcription|regulation of transcription from RNA polymerase II promoter|chromatin remodeling|transcription elongation from RNA polymerase II promoter|response to stress	chromatin binding|DNA translocase activity	RSC complex
YLR222C	YLR222C	UTP13	het	Verified	-2.14775933865846	0.0158664393648443	no	1067	0.023491050270866	3239	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	snoRNA binding	small-subunit processome|nucleolus|Pwp2p-containing subcomplex of 90S preribosome|90S preribosome
YPR110C	YPR110C	RPC40	het	Verified	-2.21996908556776	0.0132104331026858	no	1068	0.023002361597258	3263	NA	FT		NUCLEUS		RNA polymerase subunit AC40, common to RNA polymerase I and III	tRNA transcription from RNA polymerase III promoter|transcription from RNA polymerase I promoter	DNA-directed RNA polymerase activity	DNA-directed RNA polymerase III complex|DNA-directed RNA polymerase I complex
YDR464W	YDR464W	SPP41	het	Verified	-2.22953305898716	0.0128892291134632	no	1069	0.0132524151955748	3298	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Protein involved in negative regulation of expression of spliceosome components PRP4 and PRP3	negative regulation of transcription from RNA polymerase II promoter	molecular_function	nucleus
YER104W	YER104W	RTT105	het	Verified	-2.24218367964712	0.0124747517479529	no	1070	0.0191036770877482	3267	NA	FT		NUCLEUS		Protein with a role in regulation of Ty1 transposition	negative regulation of transposition, RNA-mediated	molecular_function	nucleus|cytoplasm
YOL021C	YOL021C	DIS3	het	Verified	-2.26867792317055	0.0116439595453539	no	1071	0.0349253600621824	3216	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS|MITOCHONDRION		Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3; protein abundance increases in response to DNA replication stress	nuclear mRNA surveillance|nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nonfunctional rRNA decay|nuclear polyadenylation-dependent mRNA catabolic process|rRNA catabolic process|polyadenylation-dependent snoRNA 3'-end processing|nuclear-transcribed mRNA catabolic process, non-stop decay|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ncRNA 3'-end processing	3'-5'-exoribonuclease activity|endoribonuclease activity|tRNA binding	mitochondrion|nucleolus|nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)
YFL022C	YFL022C	FRS2	het	Verified	-2.27971466543858	0.0113123084693578	no	1072	0.0107603768936032	3306	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION			Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar	phenylalanyl-tRNA aminoacylation	phenylalanine-tRNA ligase activity	phenylalanine-tRNA ligase complex|cytoplasm
YDR053W_d	YDR053W	YDR053W	het	Dubious	-2.28473139783586	0.011164291195697	no	1073	0.0093521601708135	3298	NA					Putative protein of unknown function; open reading frame overlaps 5' end of essential DBF4 gene encoding the regulatory subunit of the Cdc7p-Dbf4p kinase complex	Unknown	Unknown	Unknown
YBR152W	YBR152W	SPP381	het	Verified	-2.29102242376591	0.0109810583891431	no	1074	0.0140586434147358	3283	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING	NUCLEUS		mRNA splicing factor, component of U4/U6.U5 tri-snRNP; interacts genetically and physically with Prp38p	mRNA splicing, via spliceosome|generation of catalytic spliceosome for first transesterification step	molecular_function	U4/U6 x U5 tri-snRNP complex
YDL014W	YDL014W	NOP1	het	Verified	-2.2991864277099	0.0107471776876645	no	1075	0.0153024427817511	3288	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Nucleolar protein, component of the small subunit processome complex, which is required for processing of pre-18S rRNA; has similarity to mammalian fibrillarin	box C/D snoRNA 3'-end processing|rRNA processing|snoRNA processing|rRNA methylation	rRNA methyltransferase activity	small-subunit processome|box C/D snoRNP complex|ribosome|nucleolus|90S preribosome
YKR071C	YKR071C	DRE2	het	Verified	-2.33025517280843	0.00989633424294841	no	1076	0.0216348974453244	3267	NA	FT	COFACTOR METABOLISM	MITOCHONDRION		Component of the cytosolic Fe-S protein assembly (CIA) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18pin an early step in the CIA pathway; ortholog of human Ciapin1; protein abundance increases in response to DNA replication stress	iron-sulfur cluster assembly	electron carrier activity	cytosol|cytoplasm|mitochondrial intermembrane space
YGR280C	YGR280C	PXR1	het	Verified	-2.35802783794118	0.00918615757503428	no	1077	0.00692830941294183	3321	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain	box C/D snoRNA 3'-end processing|negative regulation of telomere maintenance via telomerase	telomerase inhibitor activity	nucleoplasm|nucleolus
YDL097C	YDL097C	RPN6	het	Verified	-2.37500457927965	0.00877436623814871	no	1078	0.029479100980172	3235	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS			Essential, non-ATPase regulatory subunit of the 26S proteasome lid; required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion; protein abundance increases in response to DNA replication stress	proteasome assembly|ubiquitin-dependent protein catabolic process	structural molecule activity	proteasome storage granule|proteasome regulatory particle, lid subcomplex
YJL104W	YJL104W	PAM16	het	Verified	-2.43564674550447	0.00743259683982231	no	1079	0.00439659898310707	3307	NA	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Constituent of the import motor (PAM complex) component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); forms a 1:1 subcomplex with Pam18p and inhibits its cochaperone activity; contains a J-like domain	protein import into mitochondrial matrix	protein domain specific binding	mitochondrion|presequence translocase-associated import motor|mitochondrial inner membrane presequence translocase complex
YDR324C	YDR324C	UTP4	het	Verified	-2.54064907506045	0.00553234565006375	no	1080	0.0171522025665865	3231	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcript	positive regulation of transcription from RNA polymerase I promoter|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	molecular_function	small-subunit processome|nucleolus|t-UTP complex|90S preribosome
YDR373W	YDR373W	FRQ1	het	Verified	-2.60181686175322	0.00463656785663853	no	1081	0.0040963379036456	3314	NA	FT	SIGNALING	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS|PLASMA MEMBRANE		N-myristoylated calcium-binding protein that may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p; member of the recoverin/frequenin branch of the EF-hand superfamily	regulation of signal transduction	enzyme activator activity|calcium ion binding	Golgi membrane
YHR143W-A	YHR143W-A	RPC10	het	Verified	-2.66336481838699	0.00386817445800267	no	1082	0.00470931535778652	3303	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RNA POL II, HOLOENZYME	RNA polymerase subunit ABC10-alpha, found in RNA pol I, II, and III; relocalizes from nucleolus to cytoplasm upon DNA replication stress	transcription from RNA polymerase I promoter|transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter	RNA-directed RNA polymerase activity|DNA-directed RNA polymerase activity	DNA-directed RNA polymerase III complex|DNA-directed RNA polymerase I complex|DNA-directed RNA polymerase II, core complex
YOR119C	YOR119C	RIO1	het	Verified	-2.7174286037459	0.00328956740860434	no	1083	0.00355750857476757	3330	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|CELL DIVISION|PROTEIN PHOSPHORYLATION	NUCLEUS		Essential serine kinase involved in cell cycle progression and processing of the 20S pre-rRNA into mature 18S rRNA	regulation of exit from mitosis|S phase of mitotic cell cycle|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	protein kinase activity	nucleus|cytoplasm
YHR172W	YHR172W	SPC97	het	Verified	-2.73298448632838	0.00313816442388643	no	1084	0.00486808702759999	3333	NA	FT	CYTOSKELETON ORGANIZATION	NUCLEUS|CYTOSKELETON		Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque	microtubule nucleation	structural constituent of cytoskeleton	outer plaque of spindle pole body|gamma-tubulin small complex, spindle pole body|inner plaque of spindle pole body
YOR278W	YOR278W	HEM4	het	Verified	-2.79110537156032	0.00262641842593875	no	1085	0.00440635826275947	3319	NA	FT	COFACTOR METABOLISM			Uroporphyrinogen III synthase, catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in heme biosynthesis; deficiency in the human homolog can result in the disease congenital erythropoietic porphyria	heme biosynthetic process	uroporphyrinogen-III synthase activity	cellular_component
YDR404C	YDR404C	RPB7	het	Verified	-2.8422103317045	0.00224009617022665	no	1086	0.0206981101137877	3291	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|TRANSLATION	NUCLEUS	RNA POL II, HOLOENZYME	RNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4p; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions; also involved in translation initiation	transcription initiation from RNA polymerase II promoter|positive regulation of translational initiation|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|nuclear-transcribed mRNA catabolic process, exonucleolytic|transcription from RNA polymerase II promoter	RNA-directed RNA polymerase activity|translation initiation factor binding|single-stranded RNA binding|single-stranded DNA binding	nucleus|DNA-directed RNA polymerase II, core complex|cytoplasmic mRNA processing body|cytoplasm
YDR472W	YDR472W	TRS31	het	Verified	-2.86464394461361	0.00208739182067224	no	1087	0.0037060557070306	3332	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOPLASMIC RETICULUM|GOLGI APPARATUS		One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic	ER to Golgi vesicle-mediated transport	Rab guanyl-nucleotide exchange factor activity	TRAPP complex
YKL033W	YKL033W	TTI1	het	Verified	-2.90229552060801	0.00185219453195597	no	1088	0.00224002215977896	3315	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS|MITOCHONDRION|CHROMOSOME		Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1; similar to S. pombe Tti1p; detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	ASTRA complex|mitochondrion|cytoplasm
YDL004W	YDL004W	ATP16	het	Verified	-3.00396690275684	0.00133242156335513	no	1089	0.00178749679684209	3329	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	MITOCHONDRION		Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated	ATP synthesis coupled proton transport	hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism	proton-transporting ATP synthase complex, catalytic core F(1)|mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase, central stalk
YMR203W	YMR203W	TOM40	het	Verified	-3.06469849594604	0.00108944766086782	no	1090	0.023843085154743	3285	NA	FF|FT	PROTEIN LOCALIZATION|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore	protein import into mitochondrial matrix	protein channel activity	mitochondrial outer membrane|mitochondrion|integral to membrane|mitochondrial outer membrane translocase complex
YLR409C	YLR409C	UTP21	het	Verified	-3.22414188138958	0.000631753908021596	yes	1091	0.00093099270543581	3348	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; synthetic defect with STI1 Hsp90 cochaperone; human homolog linked to glaucoma	ribosomal small subunit biogenesis|rRNA processing	molecular_function	small-subunit processome|nucleolus|nucleus|Pwp2p-containing subcomplex of 90S preribosome|90S preribosome
YNL152W	YNL152W	INN1	het	Verified	-3.22613984663844	0.000627360168023177	yes	1092	0.00112229188064656	3349	NA	FT	CELL CYCLE|CELL DIVISION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Essential protein that associates with contractile actomyosin ring; required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function; activates chitin synthase activity of Chs2p during cytokinesis	cytokinesis after mitosis|chromosome organization|barrier septum assembly involved in cell cycle cytokinesis|cytokinesis	phospholipid binding	cellular bud neck contractile ring|cytoplasm
YCR052W	YCR052W	RSC6	het	Verified	-4.55673319431267	2.59776757299686e-06	yes	1093	0.00244921782261605	3336	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION	NUCLEUS	RSC COMPLEX	Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p	nucleosome positioning|ATP-dependent chromatin remodeling|G2/M transition of mitotic cell cycle|G1 phase of mitotic cell cycle|nucleosome disassembly|positive regulation of transcription elongation from RNA polymerase II promoter	DNA translocase activity	RSC complex