strainid orf gene zyg qualifier SGTC_2031|5180455.score SGTC_2031|5180455.expt.zyg.pval SGTC_2031|5180455.expt.zyg.significant SGTC_2031|5180455.expt.zyg.rank strain.pval strain.rank clearance Fclass Fterms.BP Fterms.CC Fterms.complex description GO_process GO_function GO_component
YPL069C YPL069C BTS1 hom Verified 8.83651578624611 4.93750177240922e-19 yes 1 3.32219962068038e-07 29 NA FF|FT PROTEIN LOCALIZATION|LIPID METABOLISM MITOCHONDRION Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic terpenoid biosynthetic process farnesyltranstransferase activity mitochondrion
YPR197C_d YPR197C YPR197C hom Dubious 7.04771397938644 9.09405039707592e-13 yes 2 3.56313726881489e-08 15 NA FF Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YJL095W YJL095W BCK1 hom Verified 6.68854814417787 1.12697748795386e-11 yes 3 4.43236828966297e-06 115 NA FF|FT SIGNALING|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION SITE OF POLARIZED GROWTH Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p intracellular protein kinase cascade|endoplasmic reticulum unfolded protein response|peroxisome degradation|establishment of cell polarity|protein phosphorylation|response to acid|response to nutrient protein kinase activity|MAP kinase kinase kinase activity intracellular|mating projection tip
YBR058C-A YBR058C-A TSC3 hom Verified 6.29496816608683 1.53731475889841e-10 yes 4 0.000219928104393964 288 NA FF|FT KETONE METABOLISM|LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis 3-keto-sphinganine metabolic process|sphingolipid biosynthetic process enzyme activator activity SPOTS complex
YNL195C_p YNL195C YNL195C hom Uncharacterized 5.37862312494664 3.75288214875286e-08 yes 5 3.07470871688094e-07 3 NA FT MITOCHONDRION Putative protein of unknown function; shares a promoter with YNL194C; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YOL090W YOL090W MSH2 hom Verified 4.93175293258884 4.0747477151424e-07 yes 6 1.01835389253414e-06 4 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|GENE SILENCING NUCLEUS|CHROMOSOME Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity and involved in interstrand cross-link repair; Msh2p-Msh6p binds to and hydrolyzes ATP mismatch repair|mitotic recombination|meiotic gene conversion|meiotic mismatch repair|removal of nonhomologous ends|DNA recombination|chromatin silencing at silent mating-type cassette loop DNA binding|single base insertion or deletion binding|ATP binding|Y-form DNA binding|double-strand/single-strand DNA junction binding|DNA insertion or deletion binding|guanine/thymine mispair binding|four-way junction DNA binding|ATPase activity MutSbeta complex|nuclear chromosome|MutSalpha complex|nucleus
YGL253W YGL253W HXK2 hom Verified 4.73941816545784 1.07166387264169e-06 yes 7 1.47234400473467e-06 11 NA FT CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS|MITOCHONDRION Hexokinase isoenzyme 2; catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene; phosphorylation/dephosphorylation at serine-14 by protein kinase Snf1p and protein phosphatase Glc7p-Reg1p regulates nucleocytoplasmic shuttling of Hxk2p; HXK2 has a paralog, HXK1, that arose from the whole genome duplication replicative cell aging|fructose import|regulation of transcription by glucose|glucose import|mannose metabolic process|glycolysis|glucose metabolic process|regulation of cell size|fructose metabolic process hexokinase activity cytosol|mitochondrion|nucleus
YAL031C YAL031C GIP4 hom Verified 4.17633757386202 1.48120048432299e-05 yes 8 6.56356724540583e-06 11 NA FT CHROMOSOME SEGREGATION Cytoplasmic Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; potential Cdc28p substrate chromosome segregation|regulation of phosphoprotein phosphatase activity protein phosphatase 1 binding|protein phosphatase type 1 regulator activity cytoplasm
YPL141C YPL141C FRK1 hom Verified 4.15471748786956 1.62844850127422e-05 yes 9 1.24738335679628e-05 11 NA FT PROTEIN PHOSPHORYLATION Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; interacts with rRNA transcription and ribosome biogenesis factors and the long chain fatty acyl-CoA synthetase Faa3p; FRK1 has a paralog, KIN4, that arose from the whole genome duplication protein phosphorylation protein kinase activity cytoplasm
YDL053C YDL053C PBP4 hom Verified 4.13571890198718 1.76922561744565e-05 yes 10 2.84609450523174e-05 11 NA FT NUCLEUS Pbp1p binding protein; interacts strongly with Pab1p-binding protein 1 (Pbp1p) in the yeast two-hybrid system; also interacts with Lsm12p in a copurification assay; relative distribution to the nucleus increases upon DNA replication stress biological_process molecular_function nucleus|cytoplasmic stress granule|cytoplasm
YBR069C YBR069C TAT1 hom Verified 4.12948885736791 1.81785310777584e-05 yes 11 0.0141257669192982 157 NA FF|FT PLASMA MEMBRANE Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress amino acid transport|tyrosine transport|tryptophan transport|transmembrane transport amino acid transmembrane transporter activity|low-affinity tryptophan transmembrane transporter activity integral to membrane|plasma membrane
YOR188W YOR188W MSB1 hom Verified 3.91968699212211 4.43320230628152e-05 yes 12 0.000154932668914219 27 NA FT MITOCHONDRION|SITE OF POLARIZED GROWTH Protein of unknown function; may be involved in positive regulation of 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4; potential Cdc28p substrate; relocalizes from bud neck to cytoplasm upon DNA replication stress establishment of cell polarity molecular_function mitochondrion|cellular bud neck|cellular bud tip
YPR046W YPR046W MCM16 hom Verified 3.81587139988531 6.78515856762708e-05 yes 13 0.00048358528849998 31 NA FT CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME KINETOCHORE Component of the Ctf19 complex and the COMA subcomplex; involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-H and fission yeast fta3 chromosome segregation|establishment of mitotic sister chromatid cohesion molecular_function condensed nuclear chromosome kinetochore
YDL168W YDL168W SFA1 hom Verified 3.78943020885613 7.54966120933741e-05 yes 14 0.000388371637780336 14 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION Bifunctional alcohol dehydrogenase and formaldehyde dehydrogenase; formaldehyde dehydrogenase activity is glutathione-dependent; functions in formaldehyde detoxification and formation of long chain and complex alcohols, regulated by Hog1p-Sko1p; protein abundance increases in response to DNA replication stress furaldehyde metabolic process|formaldehyde catabolic process|amino acid catabolic process to alcohol via Ehrlich pathway S-(hydroxymethyl)glutathione dehydrogenase activity|hydroxymethylfurfural reductase (NADH) activity|alcohol dehydrogenase (NAD) activity mitochondrion|cytoplasm
YER119C YER119C AVT6 hom Verified 3.73115039200124 9.53036944326392e-05 yes 15 3.04755046414658e-05 10 NA FT VACUOLAR TRANSPORT Vacuolar aspartate and glutamate exporter; member of a family of seven genes (AVT1-7) related to vesicular GABA-glycine transporters; involved in compartmentalizing acidic amino acids in response to nitrogen starvation; AVT6 has a paralog, AVT5, that arose from the whole genome duplication amino acid export from vacuole|transmembrane transport L-aspartate transmembrane transporter activity|transporter activity|L-glutamate transmembrane transporter activity fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YCR066W YCR066W RAD18 hom Verified 3.65998992533073 0.000126112582421244 yes 16 0.000448970414793071 58 NA FF|FT RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME E3 ubiquitin ligase; forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; required for postreplication repair; SUMO-targeted ubiquitin ligase (STUbl) that contains a SUMO-interacting motif (SIM) which stimulates its ubiquitin ligase activity towards the sumoylated form of PCNA protein monoubiquitination|error-free translesion synthesis|error-free postreplication DNA repair|error-prone translesion synthesis ubiquitin-protein ligase activity|single-stranded DNA-dependent ATPase activity|single-stranded DNA binding nuclear chromatin|nucleus
YIL158W YIL158W AIM20 hom Verified 3.55057661557382 0.000192194118040834 yes 17 0.000296377362713992 13 NA FT CELL CYCLE Putative protein of unknown function; overexpression causes a cell cycle delay or arrest; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; null mutant displays elevated frequency of mitochondrial genome loss; relocalizes from nucleus to cytoplasm upon DNA replication stress biological_process molecular_function fungal-type vacuole
YMR017W YMR017W SPO20 hom Verified 3.51010354392174 0.000223966114146583 yes 18 5.31184250401935e-05 12 NA FT PLASMA MEMBRANE Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog ascospore-type prospore assembly SNAP receptor activity SNARE complex|prospore membrane
YGL042C_d YGL042C YGL042C hom Dubious 3.46392627033781 0.000266176200038935 yes 19 0.000262356466396354 21 NA Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene DST1 Unknown Unknown Unknown
YER134C YER134C YER134C hom Verified 3.41878000565278 0.000314512805020364 yes 20 0.000284633417054652 28 NA FT NUCLEUS Magnesium-dependent acid phosphatase, member of the haloacid dehalogenase superfamily; non-essential gene biological_process acid phosphatase activity nucleus|cytoplasm
YML036W YML036W CGI121 hom Verified 3.41198216995641 0.00032246165748552 yes 21 0.000822899206286779 35 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS|CHROMOSOME Component of the EKC/KEOPS complex with Bud32p, Kae1p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription; Cgi121p is dispensable for tRNA modification telomere maintenance|positive regulation of transcription from RNA polymerase II promoter molecular_function EKC/KEOPS complex
YDR281C YDR281C PHM6 hom Verified 3.40703085456684 0.000328368512519706 yes 22 0.000935774498215673 30 NA Protein of unknown function, expression is regulated by phosphate levels biological_process molecular_function fungal-type vacuole
YGR180C YGR180C RNR4 hom Verified 3.40272690618975 0.000333584652471548 yes 23 0.00121552032374696 30 NA FT OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM NUCLEUS Ribonucleotide-diphosphate reductase (RNR) small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits; relocalizes from nucleus to cytoplasm upon DNA replication stress cofactor biosynthetic process|deoxyribonucleotide biosynthetic process ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor ribonucleoside-diphosphate reductase complex|nucleus|cytoplasm
YJR073C YJR073C OPI3 hom Verified 3.36708640763254 0.000379834408490743 yes 24 0.00308755263824899 124 NA FF|FT LIPID METABOLISM MITOCHONDRION Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis phosphatidylcholine biosynthetic process phosphatidyl-N-dimethylethanolamine N-methyltransferase activity|phosphatidyl-N-methylethanolamine N-methyltransferase activity mitochondrion|integral to membrane
YKL183W YKL183W LOT5 hom Verified 3.33827693643193 0.000421498425136756 yes 25 0.000171915338812928 20 NA FT NUCLEUS Protein of unknown function; gene expression increases in cultures shifted to a lower temperature; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus|cytoplasm
YOR185C YOR185C GSP2 hom Verified 3.32899113098634 0.000435805899478837 yes 26 0.000746994862868122 44 NA FT PROTEIN LOCALIZATION|SIGNALING|NUCLEOTIDE METABOLISM NUCLEUS GTP binding protein (mammalian Ranp homolog); involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas); Gsp1p homolog that is not required for viability; protein abundance increases in response to DNA replication stress nucleus organization GTPase activity integral to membrane|nucleus
YNL334C YNL334C SNO2 hom Verified 3.3128026484155 0.000461830654650784 yes 27 0.000544675088786867 30 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Protein of unknown function, nearly identical to Sno3p; expression is induced before the diauxic shift and also in the absence of thiamin pyridoxine metabolic process|thiamine biosynthetic process molecular_function cellular_component
YMR241W YMR241W YHM2 hom Verified 3.29365729785429 0.000494464954529657 yes 28 0.000584301341274401 29 NA FT ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS MITOCHONDRION Carrier protein that exports citrate from and imports oxoglutarate into the mitochondrion, causing net export of NADPH reducing equivalents; also associates with mt nucleoids and has a role in replication and segregation of the mt genome tricarboxylic acid transport|mitochondrial citrate transport|alpha-ketoglutarate transport|mitochondrial genome maintenance tricarboxylate secondary active transmembrane transporter activity|DNA binding mitochondrial nucleoid|mitochondrion|integral to membrane|mitochondrial inner membrane
YDL216C YDL216C RRI1 hom Verified 3.25881026003961 0.000559402333541249 yes 29 0.00103876579960577 34 NA FT SIGNALING|PROTEOLYSIS NUCLEUS Catalytic subunit of the COP9 signalosome (CSN) complex that acts as an isopeptidase in cleaving the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; metalloendopeptidase involved in the adaptation to pheromone signaling adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|cullin deneddylation metalloendopeptidase activity signalosome
YPR022C_p YPR022C YPR022C hom Uncharacterized 3.2482903109309 0.000580503737699319 yes 30 0.000801578186748464 16 NA FT NUCLEUS Putative transcription factor, as suggested by computational analysis; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS biological_process sequence-specific DNA binding nucleus|cytoplasm
YDR137W YDR137W RGP1 hom Verified 3.22266867635121 0.00063501182205861 yes 31 0.0132383155695643 120 NA FF|FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|CELL DIVISION ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p retrograde transport, endosome to Golgi guanyl-nucleotide exchange factor activity Golgi apparatus|Ric1p-Rgp1p complex|Golgi membrane|guanyl-nucleotide exchange factor complex
YGR233C YGR233C PHO81 hom Verified 3.21405094421428 0.000654382252998223 yes 32 0.000850232361938146 46 NA FT LIPID METABOLISM NUCLEUS Cyclin-dependent kinase (CDK) inhibitor; regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; inhibitory activity for Pho80p-Pho85p requires myo-D-inositol heptakisphosphate (IP7) generated by Vip1p; relative distribution to the nucleus increases upon DNA replication stress phosphate-containing compound metabolic process cyclin-dependent protein kinase inhibitor activity nucleus|cytoplasm
YOR133W YOR133W EFT1 hom Verified 3.21201596289171 0.000659035256886303 yes 33 0.000842447535329099 58 NA FT TRANSLATION|NUCLEOTIDE METABOLISM RIBOSOME Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication translational elongation translation elongation factor activity ribosome
YOR290C YOR290C SNF2 hom Verified 3.18920391723456 0.000713326008234613 yes 34 0.0108926513112642 120 NA FF|FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS NUCLEUS RSC COMPLEX Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p cellular alcohol catabolic process|ATP-dependent chromatin remodeling|double-strand break repair|strand invasion|positive regulation of mating type switching|sucrose catabolic process|positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation|nucleosome mobilization|chromatin remodeling|DNA-dependent DNA replication|positive regulation of transcription from RNA polymerase II promoter histone acetyl-lysine binding|RNA polymerase II activating transcription factor binding|DNA-dependent ATPase activity|nucleosomal DNA binding SWI/SNF complex|nucleus
YDR503C YDR503C LPP1 hom Verified 3.18762893294175 0.00071722244833952 yes 35 0.000216065478265551 17 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Lipid phosphate phosphatase, catalyzes Mg(2+)-independent dephosphorylation of phosphatidic acid (PA), lysophosphatidic acid, and diacylglycerol pyrophosphate; involved in control of the cellular levels of phosphatidylinositol and PA phospholipid metabolic process phosphatidate phosphatase activity integral to membrane|membrane
YBL091C-A YBL091C-A SCS22 hom Verified 3.18611372602474 0.000720989509614536 yes 36 0.000638454654002845 43 NA FT LIPID METABOLISM Protein involved in regulation of phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; similar to D. melanogaster inturned protein; SCS22 has a paralog, SCS2, that arose from the whole genome duplication phospholipid biosynthetic process|chromatin silencing at telomere molecular_function cellular_component
YGL066W YGL066W SGF73 hom Verified 3.16912804024333 0.00076448511214402 yes 37 0.00210925174585401 46 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|RNA LOCALIZATION NUCLEUS HISTONE ACETYLTRANSFERASE SAGA complex subunit; has a role in anchoring the deubiquitination module into SAGA and SLIK complexes; involved in preinitiation complex assembly at promoters; human ortholog ataxin-7 is associated with spinocerebellar ataxia diseases; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay histone deubiquitination|mRNA export from nucleus|histone acetylation|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|protein complex assembly|chromatin modification histone acetyltransferase activity|enzyme activator activity|structural molecule activity DUBm complex|SLIK (SAGA-like) complex|SAGA complex
YAL005C YAL005C SSA1 hom Verified 3.1409989709457 0.000841863120018667 yes 38 0.000219352466939423 17 NA FT PROTEIN LOCALIZATION|TRANSLATION|MITOCHONDRION ORGANIZATION NUCLEUS ATPase involved in protein folding and NLS-directed nuclear transport; member of HSP70 family; forms chaperone complex with Ydj1p; localized to nucleus, cytoplasm, and cell wall; 98% identical with paralog Ssa2p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes; general targeting factor of Hsp104p to prion fibrils cytoplasmic translation|protein folding|protein refolding|protein targeting to mitochondrion|SRP-dependent cotranslational protein targeting to membrane, translocation|protein import into nucleus, translocation|response to stress unfolded protein binding|ATPase activity fungal-type vacuole membrane|fungal-type cell wall|plasma membrane|nucleus|polysome|chaperonin-containing T-complex|cytoplasm
YGL243W YGL243W TAD1 hom Verified 3.13773876306316 0.000851282725315254 yes 39 0.000308120048601384 14 NA FT RNA PROCESSING NUCLEUS tRNA-specific adenosine deaminase, deaminates adenosine-37 to inosine in tRNA-Ala tRNA modification tRNA-specific adenosine-37 deaminase activity nucleus
YDR519W YDR519W FPR2 hom Verified 3.09012441370645 0.00100036334420378 no 40 0.00286536966472166 49 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase); binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking; relocalizes from nucleus to vacuole upon DNA replication stress biological_process FK506 binding|peptidyl-prolyl cis-trans isomerase activity endoplasmic reticulum membrane
YLR303W YLR303W MET17 hom Verified 3.07099765279608 0.00106672414021349 no 41 0.001802875682048 66 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Methionine and cysteine synthase (O-acetyl homoserine-O-acetyl serine sulfhydrylase), required for sulfur amino acid synthesis methionine metabolic process|cysteine biosynthetic process O-acetylhomoserine aminocarboxypropyltransferase activity|cysteine synthase activity plasma membrane|cytoplasm
YOR196C YOR196C LIP5 hom Verified 3.03782517712804 0.00119146076880308 no 42 0.00248841241376645 86 NA FT KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM MITOCHONDRION Protein involved in biosynthesis of the coenzyme lipoic acid, has similarity to E. coli lipoic acid synthase protein lipoylation lipoate synthase activity mitochondrion
YDL223C YDL223C HBT1 hom Verified 3.02993423890626 0.0012230349593123 no 43 0.00312331533964191 82 NA Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis cell morphogenesis involved in conjugation with cellular fusion molecular_function plasma membrane|mating projection
YLR264W YLR264W RPS28B hom Verified 2.97077685445956 0.0014852376470673 no 44 0.00208711578933508 32 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S28, no bacterial homolog; RPS28B has a paralog, RPS28A, that arose from the whole genome duplication cytoplasmic translation|rRNA export from nucleus structural constituent of ribosome cytosolic small ribosomal subunit
YBR010W YBR010W HHT1 hom Verified 2.96953171655621 0.00149127010955856 no 45 0.00202113970514001 48 NA FT CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT2); regulated by acetylation, methylation, and phosphorylation chromatin assembly or disassembly|global genome nucleotide-excision repair|rRNA transcription|sexual sporulation resulting in formation of a cellular spore|mitotic cell cycle spindle assembly checkpoint DNA binding replication fork protection complex|nucleus|nuclear nucleosome
YGR067C_p YGR067C YGR067C hom Uncharacterized 2.96754021777291 0.00150096503555292 no 46 0.00069990617816688 21 NA FT NUCLEUS Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p biological_process sequence-specific DNA binding cellular_component
YHR159W_p YHR159W TDA11 hom Uncharacterized 2.9589724703582 0.00154333337264087 no 47 0.00330747563438475 52 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; potential Cdc28p substrate; null mutant is sensitive to expression of the top1-T722A allele biological_process molecular_function cytoplasm
YIR023W YIR023W DAL81 hom Verified 2.95778153720366 0.00154930821144429 no 48 0.0536637082048914 429 NA FF|FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|RESPONSE TO NUTRIENT LEVELS NUCLEUS Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism nitrogen utilization|nitrogen catabolite activation of transcription from RNA polymerase II promoter|gamma-aminobutyric acid catabolic process|urea catabolic process RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor recruiting transcription factor activity nucleus
YBR014C YBR014C GRX7 hom Verified 2.95392271735229 0.00156881284480731 no 49 0.000883938833846158 35 NA FT RESPONSE TO OXIDATIVE STRESS GOLGI APPARATUS Cis-golgi localized monothiol glutaredoxin; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; does not bind metal ions; GRX7 has a paralog, GRX6, that arose from the whole genome duplication cellular response to oxidative stress glutathione-disulfide reductase activity|protein homodimerization activity integral to membrane|Golgi apparatus|Golgi lumen|fungal-type vacuole|cis-Golgi network
YGR106C YGR106C VOA1 hom Verified 2.94547664204573 0.00161228746862152 no 50 0.00976575398790576 112 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Endoplasmic reticulum protein that functions, together with other assembly factors, in assembly of the V0 sector of the vacuolar ATPase (V-ATPase); null mutation enhances the V-ATPase deficiency of a vma21 mutant impaired in ER retrieval protein complex assembly molecular_function fungal-type vacuole membrane|endoplasmic reticulum membrane
YGR159C YGR159C NSR1 hom Verified 2.94427578602089 0.00161855701438051 no 51 0.0033041084932584 26 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS|MITOCHONDRION Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis ribosomal small subunit assembly|rRNA processing single-stranded DNA binding|RNA binding mitochondrion|nucleolus|nucleus
YNL121C YNL121C TOM70 hom Verified 2.93128870801222 0.00168779453825556 no 52 0.00888319900741783 96 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Component of the TOM (translocase of outer membrane) complex; involved in the recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins; TOM70 has a paralog, TOM71, that arose from the whole genome duplication protein import into mitochondrial matrix|protein import into mitochondrial inner membrane mitochondrion targeting sequence binding|protein channel activity mitochondrial outer membrane|mitochondrion|integral to membrane|integral to mitochondrial outer membrane|mitochondrial outer membrane translocase complex
YNR008W YNR008W LRO1 hom Verified 2.92359465292898 0.00173007503817288 no 53 0.00166829743347961 78 NA FT LIPID METABOLISM ENDOPLASMIC RETICULUM Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase lipid storage|triglyceride biosynthetic process phospholipid:diacylglycerol acyltransferase activity lipid particle|perinuclear endoplasmic reticulum
YKR047W_d YKR047W YKR047W hom Dubious 2.83102082923685 0.00231998496392103 no 54 0.00403189213297178 79 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NAP1 Unknown Unknown Unknown
YGL004C YGL004C RPN14 hom Verified 2.80953590397435 0.00248064924762564 no 55 0.00323538338080321 17 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS NUCLEUS Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p proteasome regulatory particle assembly|ubiquitin-dependent protein catabolic process molecular_function cytosol|nucleus|cytoplasm
YNR073C_p YNR073C YNR073C hom Uncharacterized 2.80648328980048 0.00250427550751404 no 56 0.0042324823697703 27 NA Putative mannitol dehydrogenase; identical in amino acid sequence to Dsf1p biological_process mannitol dehydrogenase activity cellular_component
YIR017C YIR017C MET28 hom Verified 2.77240730762247 0.00278216820185655 no 57 0.00662599169670937 51 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Basic leucine zipper (bZIP) transcriptional activator in the Cbf1p-Met4p-Met28p complex, participates in the regulation of sulfur metabolism regulation of transcription from RNA polymerase II promoter|regulation of sulfur amino acid metabolic process|Unknown RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YCR044C YCR044C PER1 hom Verified 2.76788144764804 0.00282109878395008 no 58 0.0262960939508141 163 NA FF|FT LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein of the endoplasmic reticulum, required for GPI-phospholipase A2 activity that remodels the GPI anchor as a prerequisite for association of GPI-anchored proteins with lipid rafts; functionally complemented by human ortholog PERLD1 GPI anchor biosynthetic process|cellular manganese ion homeostasis molecular_function fungal-type vacuole membrane|integral to membrane|endoplasmic reticulum
YDR463W YDR463W STP1 hom Verified 2.75308291832076 0.0029518470731073 no 59 0.0178278105666176 105 NA FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS|PLASMA MEMBRANE Transcription factor; undergoes proteolytic processing by SPS (Ssy1p-Ptr3p-Ssy5p)-sensor component Ssy5p in response to extracellular amino acids; activates transcription of amino acid permease genes and may have a role in tRNA processing; STP1 has a paralog, STP2, that arose from the whole genome duplication positive regulation of transcription, DNA-dependent|tRNA splicing, via endonucleolytic cleavage and ligation|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription plasma membrane|nucleus|cytoplasm
YPL157W YPL157W TGS1 hom Verified 2.75223081089468 0.00295953933107622 no 60 0.00406915881295176 98 NA FT CELL CYCLE|RNA PROCESSING NUCLEUS Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs meiosis|RNA methylation|nucleologenesis|7-methylguanosine cap hypermethylation|regulation of telomere maintenance via telomerase RNA methyltransferase activity nucleolus
YER042W YER042W MXR1 hom Verified 2.73717472114234 0.00309846851858199 no 61 0.00539388216012244 71 NA FT OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS NUCLEUS Methionine-S-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR2; involved in the regulation of lifespan cellular response to oxidative stress peptide-methionine-(S)-S-oxide reductase activity nucleus|cytoplasm
YJL052W YJL052W TDH1 hom Verified 2.73165184719415 0.00315088469955249 no 62 0.011413382690451 90 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress gluconeogenesis|glycolysis glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity mitochondrion|fungal-type cell wall|lipid particle|plasma membrane|cytoplasm
YPL201C YPL201C YIG1 hom Verified 2.72932037318198 0.00317325069398635 no 63 0.00360217700792549 72 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol glycerol biosynthetic process molecular_function cytosol|nucleus
YBR007C YBR007C DSF2 hom Verified 2.72414381946983 0.00322342130897188 no 64 0.00461855577194717 146 NA FF Deletion suppressor of mpt5 mutation; relocalizes from bud neck to cytoplasm upon DNA replication stress biological_process molecular_function cellular_component
YCR092C YCR092C MSH3 hom Verified 2.70771850811149 0.00338737284934821 no 65 0.00506053113880445 93 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Mismatch repair protein, forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability mismatch repair|mitotic recombination|meiotic mismatch repair|removal of nonhomologous ends|DNA recombination DNA insertion or deletion binding|mismatched DNA binding|double-strand/single-strand DNA junction binding|loop DNA binding|Y-form DNA binding MutSbeta complex|nucleus|cytoplasm
YFR013W YFR013W IOC3 hom Verified 2.70580009215663 0.00340700256619182 no 66 0.00659719661385193 106 NA FT CHROMATIN ORGANIZATION NUCLEUS Subunit of the Isw1a complex; Isw1a has nucleosome-stimulated ATPase activity and represses transcription initiation by specific positioning of a promoter proximal dinucleosome; IOC3 has a paralog, ESC8, that arose from the whole genome duplication chromatin remodeling nucleosome binding|ATPase activity|DNA binding ISW1 complex
YML099C YML099C ARG81 hom Verified 2.69703638806604 0.00349798125605356 no 67 0.00426281786379286 62 NA FT VESICLE-MEDIATED TRANSPORT|TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type, involved in the regulation of arginine-responsive genes; acts with Arg80p and Arg82p arginine metabolic process|negative regulation of calcium ion-dependent exocytosis transcription cofactor activity nucleus
YPR017C YPR017C DSS4 hom Verified 2.6968800975495 0.00349962337287166 no 68 0.00412827502124842 93 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING Guanine nucleotide dissociation stimulator for Sec4p, functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol post-Golgi vesicle-mediated transport zinc ion binding|guanyl-nucleotide exchange factor activity cytosol|membrane
YGR260W YGR260W TNA1 hom Verified 2.68947658835022 0.00357820833325689 no 69 0.00596007382408309 56 NA FT MITOCHONDRION|PLASMA MEMBRANE High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA) nicotinamide mononucleotide transport nicotinamide mononucleotide transmembrane transporter activity mitochondrion|integral to membrane|integral to plasma membrane
YAR003W YAR003W SWD1 hom Verified 2.67487747388301 0.00373782830483395 no 70 0.00714487519062445 89 NA FT CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member with similarity to mammalian Rbbp7 histone H3-K4 methylation|telomere maintenance|regulation of transcription, DNA-dependent|chromatin silencing at telomere histone methyltransferase activity (H3-K4 specific) Set1C/COMPASS complex
YOR096W YOR096W RPS7A hom Verified 2.6746567938008 0.00374028934952291 no 71 0.00893054532580855 84 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION NUCLEUS RIBOSOME Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7A has a paralog, RPS7B, that arose from the whole genome duplication cytoplasmic translation|ribosome biogenesis structural constituent of ribosome small-subunit processome|cytosolic small ribosomal subunit|90S preribosome
YBR101C YBR101C FES1 hom Verified 2.65088458926554 0.00401406344239554 no 72 0.00384894952154567 61 NA FT TRANSLATION RIBOSOME Hsp70 (Ssa1p) nucleotide exchange factor; cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum; protein abundance increases in response to DNA replication stress cytoplasmic translation adenyl-nucleotide exchange factor activity cytosol|cytosolic ribosome
YDR028C YDR028C REG1 hom Verified 2.64565419106526 0.00407665595297701 no 73 0.0367042233616716 300 NA FF|FT TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Regulatory subunit of type 1 protein phosphatase Glc7p; involved in negative regulation of glucose-repressible genes; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p cellular response to glucose starvation|vacuolar protein catabolic process|glycogen metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of carbohydrate metabolic process protein phosphatase type 1 regulator activity protein phosphatase type 1 complex|cytoplasm
YOR134W YOR134W BAG7 hom Verified 2.64378375488537 0.00409925075885713 no 74 0.00613922891919575 85 NA FT SIGNALING Rho GTPase activating protein (RhoGAP), stimulates the intrinsic GTPase activity of Rho1p, which plays a role in actin cytoskeleton organization and control of cell wall synthesis; structurally and functionally related to Sac7p small GTPase mediated signal transduction Rho GTPase activator activity intracellular
YDR287W YDR287W INM2 hom Verified 2.64000550167587 0.00414523406763138 no 75 0.00356635647430229 55 NA FT LIPID METABOLISM|CARBOHYDRATE METABOLISM Inositol monophosphatase, involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy inositol phosphate dephosphorylation inositol monophosphate 1-phosphatase activity cellular_component
YPR132W YPR132W RPS23B hom Verified 2.62239633735778 0.00436569127362907 no 76 0.00422077249149052 42 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23B has a paralog, RPS23A, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|regulation of translational fidelity structural constituent of ribosome cytosolic small ribosomal subunit
YJR152W YJR152W DAL5 hom Verified 2.59960020984089 0.00466662118427738 no 77 0.0043698120088746 33 NA FT PLASMA MEMBRANE Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression dipeptide transport|allantoate transport dipeptide transporter activity|allantoate transmembrane transporter activity integral to membrane|plasma membrane
YPR196W_p YPR196W YPR196W hom Uncharacterized 2.59803265805275 0.00468797881182091 no 78 0.00363344292671936 65 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Putative maltose-responsive transcription factor regulation of transcription, DNA-dependent sequence-specific DNA binding cellular_component
YOR227W YOR227W HER1 hom Verified 2.58836886115201 0.0048215828593641 no 79 0.00609054016348001 47 NA FT MITOCHONDRION Protein of unknown function required for proliferation or remodeling of the ER that is caused by overexpression of Hmg2p; may interact with ribosomes, based on co-purification experiments; HER1 has a paralog, GIP3, that arose from the whole genome duplication endoplasmic reticulum organization molecular_function mitochondrion|ribosome|cytoplasm
YMR053C YMR053C STB2 hom Verified 2.5864464436304 0.00484856194507929 no 80 0.00373606916919514 93 NA FT NUCLEUS|CHROMOSOME Protein that interacts with Sin3p in a two-hybrid assay and is part of a large protein complex with Sin3p and Stb1p biological_process molecular_function Sin3-type complex
YLR168C YLR168C UPS2 hom Verified 2.58412783077445 0.00488128017223451 no 81 0.00448476865660071 77 NA FT LIPID METABOLISM|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial protein involved in phospholipid metabolism; localizes to the intermembrane space; has a role in regulation of phospholipid metabolism by inhibiting conversion of phosphatidylethanolamine to phosphatidylcholine; null mutant has defects in mitochondrial morphology; similar to Ups1p, Ups3p and to human PRELI cristae formation|Unknown|phosphatidylethanolamine metabolic process|cardiolipin metabolic process molecular_function extrinsic to mitochondrial inner membrane|mitochondrion|mitochondrial intermembrane space
YOL132W YOL132W GAS4 hom Verified 2.54081024668634 0.00552979620002607 no 82 0.00384910398676479 61 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM PLASMA MEMBRANE 1,3-beta-glucanosyltransferase, involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall ascospore wall assembly 1,3-beta-glucanosyltransferase activity fungal-type cell wall|integral to membrane
YLR261C_d YLR261C VPS63 hom Dubious 2.53224483470179 0.00566674123025827 no 83 0.0455141372968129 232 NA FF Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect Unknown Unknown Unknown
YGR249W YGR249W MGA1 hom Verified 2.52517827377236 0.0057819805304418 no 84 0.00676343752244584 80 NA FT NUCLEUS Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants filamentous growth sequence-specific DNA binding|DNA binding|sequence-specific DNA binding transcription factor activity nucleus
YHR030C YHR030C SLT2 hom Verified 2.52367596659665 0.00580674606997745 no 85 0.0415919286054499 406 NA FF|FT PROTEIN LOCALIZATION|RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|CELL DIVISION|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION NUCLEUS|SITE OF POLARIZED GROWTH Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, progression through the cell cycle, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to the phagophore assembly site (PAS); regulated by the PKC1-mediated signaling pathway protein phosphorylation|endoplasmic reticulum unfolded protein response|signal transduction|UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response|fungal-type cell wall organization|peroxisome degradation|regulation of transcription factor import into nucleus|barrier septum assembly|response to acid|regulation of cell size MAP kinase activity|protein serine/threonine kinase activity|protein kinase activity nucleus|cytoplasm|cellular bud tip
YBR268W YBR268W MRPL37 hom Verified 2.51841416287736 0.00589423066275029 no 86 0.017823857674342 134 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YBL083C_d YBL083C YBL083C hom Dubious 2.49146547746505 0.00636086647665893 no 87 0.00665073541763294 125 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified ORF ALG3 Unknown Unknown Unknown
YGL107C YGL107C RMD9 hom Verified 2.48839769201162 0.00641600756190709 no 88 0.0089840055661641 77 NA FT TRANSLATION|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes translational initiation|regulation of mRNA stability|aerobic respiration molecular_function extrinsic to mitochondrial inner membrane|mitochondrion
YGL258W YGL258W VEL1 hom Verified 2.48631292644079 0.00645372060030659 no 89 0.0140284023796862 103 NA Protein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants; VEL1 has paralog YOR387C biological_process molecular_function cytosol
YLR049C_p YLR049C YLR049C hom Uncharacterized 2.48344488465681 0.00650592341544807 no 90 0.0011132587424126 29 NA Putative protein of unknown function biological_process molecular_function cellular_component
YHL020C YHL020C OPI1 hom Verified 2.48283026603912 0.00651715890390049 no 91 0.00965217579249203 99 NA FT TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM|SIGNALING ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Transcriptional regulator of a variety of genes; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; involved in telomere maintenance endoplasmic reticulum unfolded protein response|negative regulation of transcription from RNA polymerase II promoter|phospholipid biosynthetic process|positive regulation of transcription from RNA polymerase II promoter transcription corepressor activity nuclear membrane|nucleoplasm|nuclear envelope|endoplasmic reticulum|nucleus
YBL057C YBL057C PTH2 hom Verified 2.47050691661764 0.0067460854894811 no 92 0.00932315049929227 79 NA FT PROTEOLYSIS MITOCHONDRION One of two (see also PTH1) mitochondrially-localized peptidyl-tRNA hydrolases; negatively regulates the ubiquitin-proteasome pathway via interactions with ubiquitin-like ubiquitin-associated proteins; dispensable for cell growth negative regulation of proteasomal ubiquitin-dependent protein catabolic process aminoacyl-tRNA hydrolase activity mitochondrial outer membrane|mitochondrion|cytoplasm
YDL076C YDL076C RXT3 hom Verified 2.46215660985793 0.0069052174193071 no 93 0.0098642523264405 100 NA FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Subunit of the RPD3L complex; involved in histone deacetylation; protein abundance increases in response to DNA replication stress negative regulation of transcription from RNA polymerase I promoter molecular_function Rpd3L-Expanded complex|nucleus|Rpd3L complex
YLR313C YLR313C SPH1 hom Verified 2.45736594990172 0.00699800167604446 no 94 0.00933436328480488 118 NA FT CELL CYCLE|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Protein involved in shmoo formation and bipolar bud site selection; homologous to Spa2p, localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p bipolar cellular bud site selection|pseudohyphal growth|invasive filamentous growth|mating projection assembly molecular_function incipient cellular bud site|cellular bud neck|cellular bud tip|mating projection
YIL138C YIL138C TPM2 hom Verified 2.44518565112792 0.00723887977076085 no 95 0.0107434111801652 109 NA FT VESICLE-MEDIATED TRANSPORT|CELL DIVISION|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|RNA LOCALIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Minor isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p; TPM2 has a paralog, TPM1, that arose from the whole genome duplication vacuole inheritance|exocytosis|intracellular mRNA localization|budding cell apical bud growth|budding cell isotropic bud growth|mitochondrion inheritance|actin polymerization or depolymerization|vesicle-mediated transport|actin filament organization|establishment of cell polarity|actin filament bundle assembly actin lateral binding cellular bud neck contractile ring|actin filament bundle
YLR325C YLR325C RPL38 hom Verified 2.43384811759447 0.00746963112034519 no 96 0.0134463033018712 86 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L38; homologous to mammalian ribosomal protein L38, no bacterial homolog cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YBR146W YBR146W MRPS9 hom Verified 2.41211640846392 0.00793010839705391 no 97 0.00910951053130376 93 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YBR086C YBR086C IST2 hom Verified 2.40068804268195 0.00818214024808379 no 98 0.0106698449356024 60 NA FT PLASMA MEMBRANE Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localizes to the mother cell in small-budded cells and to the bud in medium- and large-budded cells; mRNA is transported to the bud tip by an actomyosin-driven process response to osmotic stress lipid binding integral to membrane|cellular bud membrane|plasma membrane
YPL062W_d YPL062W YPL062W hom Dubious 2.39780666359952 0.00824678413136895 no 99 0.0151228332595798 145 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPL062W is not an essential gene; homozygous diploid mutant shows a decrease in glycogen accumulation Unknown Unknown Unknown
YKR011C YKR011C YKR011C hom Verified 2.39567641157011 0.00829486445110315 no 100 0.00566995896200948 79 NA FT NUCLEUS Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus
YLR374C_d YLR374C YLR374C hom Dubious 2.39077284791622 0.00840647567696201 no 101 0.0234243765226848 139 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF STP3/YLR375W Unknown Unknown Unknown
YDR484W YDR484W VPS52 hom Verified 2.37744239073371 0.00871658295223927 no 102 0.0355509814385295 161 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT GOLGI APPARATUS|CYTOSKELETON Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin actin filament-based process|Golgi to vacuole transport|retrograde transport, endosome to Golgi protein binding Golgi apparatus|GARP complex
YDL073W_p YDL073W YDL073W hom Uncharacterized 2.37335743572231 0.00881359821507077 no 103 0.0167228114135779 111 NA Putative protein of unknown function; YDL073W is not an essential gene biological_process molecular_function cellular_component
YDR198C YDR198C RKM2 hom Verified 2.36991678980834 0.00889604449666118 no 104 0.0121157558239869 65 NA Ribosomal protein lysine methyltransferase, responsible for trimethylation of the lysine residue at position 3 of Rpl12Ap and Rpl12Bp peptidyl-lysine trimethylation|peptidyl-lysine monomethylation protein-lysine N-methyltransferase activity cellular_component
YGL085W_p YGL085W LCL3 hom Uncharacterized 2.36610090928862 0.00898827196690841 no 105 0.00620105818867756 70 NA FT MITOCHONDRION Putative protein of unknown function; mutant has long chronological lifespan; has homology to Staphylococcus aureus nuclease; GFP-fusion protein localizes to mitochondria; is induced in response to the DNA-damaging agent MMS biological_process molecular_function mitochondrion
YDR169C-A_p YDR169C-A YDR169C-A hom Uncharacterized 2.36118338500088 0.00910835992733171 no 106 0.0115929122618261 96 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YNR025C_d YNR025C YNR025C hom Dubious 2.3551257320066 0.00925821965215251 no 107 0.0067562288726027 86 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion reduces expression of PIS1 gene encoding phosphatidylinositol synthase Unknown Unknown Unknown
YCR032W YCR032W BPH1 hom Verified 2.33150761435404 0.00986330451896736 no 108 0.0100805076850951 115 NA FT PROTEIN LOCALIZATION|CELL WALL ORG/BIOGENESIS MITOCHONDRION Protein homologous to Chediak-Higashi syndrome and Beige proteins; both of which are implicated in disease syndromes in human and mouse, respectively, due to defective lysosomal trafficking; mutant phenotype and genetic interactions suggest a role in protein sorting intracellular protein transport|fungal-type cell wall organization|response to pH molecular_function cytosol|mitochondrion|extrinsic to membrane
YPL148C YPL148C PPT2 hom Verified 2.32642664812779 0.00999790069419584 no 109 0.0329452223455974 194 NA FF|FT KETONE METABOLISM|LIPID METABOLISM MITOCHONDRION Phosphopantetheine:protein transferase (PPTase), activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation protein-cofactor linkage holo-[acyl-carrier-protein] synthase activity mitochondrion
YHR179W YHR179W OYE2 hom Verified 2.31557177052816 0.0102908308329331 no 110 0.00974565082312653 162 NA FT OXIDATION-REDUCTION PROCESS NUCLEUS|MITOCHONDRION Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress apoptotic process NADPH dehydrogenase activity mitochondrion|nucleus|cytoplasm
YDR089W YDR089W YDR089W hom Verified 2.3058776498317 0.0105587349065907 no 111 0.00408712053602021 52 NA FT MEMBRANE ORGANIZATION Protein of unknown function; deletion confers resistance to nickel; contains an SPX domain, which is found in proteins involved in phosphate homeostasis; relocalizes from vacuole to cytoplasm upon DNA replication stress cellular membrane organization molecular_function integral to membrane|membrane
YLR338W_d YLR338W OPI9 hom Dubious 2.30496779679686 0.0105841885205522 no 112 0.0357914973747355 254 NA FF Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF VRP1/YLR337C Unknown Unknown Unknown
YJR063W YJR063W RPA12 hom Verified 2.30038256946317 0.010713277728737 no 113 0.0194792150458043 186 NA FF|FT NUCLEUS RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex termination of RNA polymerase I transcription|transcription of nuclear large rRNA transcript from RNA polymerase I promoter molecular_function DNA-directed RNA polymerase I complex
YKR005C_p YKR005C YKR005C hom Uncharacterized 2.29858508845805 0.0107642555482358 no 114 0.00890162867521548 93 NA Putative protein of unknown function biological_process molecular_function cellular_component
YGR270W YGR270W YTA7 hom Verified 2.29120983286535 0.0109756402694175 no 115 0.029331020407763 153 NA FT TRANSCRIPTION FROM RNA POL II|GENE SILENCING ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Protein that localizes to chromatin and has a role in regulation of histone gene expression; has a bromodomain-like region that interacts with the N-terminal tail of histone H3, and an ATPase domain; potentially phosphorylated by Cdc28p negative regulation of transcription from RNA polymerase II promoter|negative regulation of chromatin silencing|positive regulation of transcription from RNA polymerase II promoter chromatin binding|histone binding extrinsic to endoplasmic reticulum membrane|nucleus
YJL211C_d YJL211C YJL211C hom Dubious 2.28992080703204 0.011012953913857 no 116 0.0104549274834052 77 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL210W/PEX2 Unknown Unknown Unknown
YOL108C YOL108C INO4 hom Verified 2.28374579252755 0.0111932375607393 no 117 0.0134967894153581 139 NA FT TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM NUCLEUS Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain phospholipid biosynthetic process|positive regulation of transcription from RNA polymerase II promoter DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YAL007C YAL007C ERP2 hom Verified 2.28289754228448 0.0112182021493437 no 118 0.010640952679771 85 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein that forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles ER to Golgi vesicle-mediated transport molecular_function ER to Golgi transport vesicle
YKL040C YKL040C NFU1 hom Verified 2.2816112407942 0.0112561512391967 no 119 0.0061838915813816 50 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS|COFACTOR METABOLISM MITOCHONDRION Protein involved in iron metabolism in mitochondria; similar to NifU, which is a protein required for the maturation of the Fe/S clusters of nitrogenase in nitrogen-fixing bacteria cellular iron ion homeostasis|iron-sulfur cluster assembly|intracellular sequestering of iron ion molecular_function mitochondrion|mitochondrial matrix
YKL071W_p YKL071W YKL071W hom Uncharacterized 2.28075782930844 0.0112813905310906 no 120 0.0127756163592346 80 NA FT OXIDATION-REDUCTION PROCESS Putative protein of unknown function; expression induced in cells treated with the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm biological_process molecular_function integral to membrane|cytoplasm
YGR248W YGR248W SOL4 hom Verified 2.27987560318123 0.0113075336977466 no 121 0.00900986047431394 81 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS NUCLEUS 6-phosphogluconolactonase; protein abundance increases in response to DNA replication stress; SOL4 has a paralog, SOL3, that arose from the whole genome duplication pentose-phosphate shunt, oxidative branch 6-phosphogluconolactonase activity cytosol|nucleus|cytoplasm
YCR073W-A YCR073W-A SOL2 hom Verified 2.27030046708963 0.0115946793720635 no 122 0.0150052451729421 154 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|RNA LOCALIZATION|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL2 has a paralog, SOL1, that arose from the whole genome duplication tRNA export from nucleus molecular_function|6-phosphogluconolactonase activity cytosol|cytoplasm
YNL069C YNL069C RPL16B hom Verified 2.2600172682542 0.0119100895617095 no 123 0.0210697644484968 131 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L16B; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16B has a paralog, RPL16A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YMR172C-A_d YMR172C-A YMR172C-A hom Dubious 2.25081693351751 0.0121985672881352 no 124 0.0119090824466806 126 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YAR035C-A_p YAR035C-A YAR035C-A hom Uncharacterized 2.25068713246982 0.012202680161865 no 125 0.00735424189301106 115 NA Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; predicted to have a role in cell budding based on computational guilt by association analysis biological_process molecular_function cellular_component
YML038C YML038C YMD8 hom Verified 2.21650135322821 0.0133285926540967 no 126 0.0138309573076666 96 NA FT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Putative nucleotide sugar transporter, has similarity to Vrg4p UDP-glucose transport|nucleotide-sugar transport nucleotide-sugar transmembrane transporter activity COPI-coated vesicle|integral to membrane
YOL101C YOL101C IZH4 hom Verified 2.21572009526114 0.0133553388858412 no 127 0.0145259530228143 108 NA FT LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family; expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism; protein increases in abundance and relocalizes from nucleus to ER upon DNA replication stress cellular zinc ion homeostasis|cellular lipid metabolic process metal ion binding integral to membrane|membrane
YNL190W_p YNL190W YNL190W hom Uncharacterized 2.21424075738785 0.0134061107609773 no 128 0.0165405507960522 131 NA Hydrophilin essential in dessication-rehydration process; cell wall protein; contains a putative GPI-attachment site cellular response to water deprivation molecular_function fungal-type cell wall
YIL017C YIL017C VID28 hom Verified 2.21304337904005 0.0134473275565308 no 129 0.0172121952300566 92 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS NUCLEUS GID Complex subunit, serves as adaptor for regulatory subunit Vid24p; protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); localized to the nucleus and the cytoplasm negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|vacuolar protein catabolic process|ascospore formation|positive regulation of transcription from RNA polymerase II promoter molecular_function nucleus|GID complex|cytoplasm
YOR008C YOR008C SLG1 hom Verified 2.21019275902098 0.0135458936519704 no 130 0.0524967806959393 267 NA FF|FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|PEROXISOME ORGANIZATION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway; involved in maintenance of cell wall integrity; required for mitophagy; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response positive regulation of endocytosis|Rho protein signal transduction|actin cytoskeleton organization|fungal-type cell wall organization|response to heat|peroxisome degradation|establishment of cell polarity|response to osmotic stress transmembrane signaling receptor activity plasma membrane|mating projection tip|cellular bud neck
YGR086C YGR086C PIL1 hom Verified 2.20720958713426 0.0136497101474283 no 131 0.00993564203910298 99 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION MITOCHONDRION Primary protein component of eisosomes; eisosomes are large immobile cell cortex structures associated with endocytosis; null mutant shows activation of Pkc1p/Ypk1p stress resistance pathways; detected in phosphorylated state in mitochondria; member of the BAR domain family; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress eisosome assembly|endocytosis|negative regulation of protein kinase activity|response to heat|protein localization lipid binding mitochondrial outer membrane|eisosome|mitochondrion|plasma membrane|cytoplasm
YBR158W YBR158W AMN1 hom Verified 2.20714268014485 0.0136520464081342 no 132 0.0149205751226654 116 NA FT CELL CYCLE|CELL DIVISION NUCLEUS Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN) mitotic cell cycle checkpoint|negative regulation of exit from mitosis protein binding nucleus|cellular bud|cytoplasm
YJL146W YJL146W IDS2 hom Verified 2.19973530317113 0.0139128402602085 no 133 0.0106378321001609 76 NA FT CELL CYCLE NUCLEUS Protein involved in modulation of Ime2p activity during meiosis, appears to act indirectly to promote Ime2p-mediated late meiotic functions; found in growing cells and degraded during sporulation meiosis molecular_function nucleus|cytoplasm
YOR045W YOR045W TOM6 hom Verified 2.1890768249925 0.0142956283199796 no 134 0.0125145177720269 115 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex mitochondrial outer membrane translocase complex assembly|protein import into mitochondrial matrix protein channel activity mitochondrion|integral to membrane|mitochondrial outer membrane translocase complex
YGL028C YGL028C SCW11 hom Verified 2.18389891093598 0.0144848385366138 no 135 0.0177442506421341 108 NA FT CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p cytokinesis, completion of separation glucan endo-1,3-beta-D-glucosidase activity fungal-type cell wall
YDL039C YDL039C PRM7 hom Verified 2.17818693699948 0.0146960611035433 no 136 0.012400926336564 56 NA Pheromone-regulated protein, predicted to have one transmembrane segment; promoter contains Gcn4p binding elements conjugation with cellular fusion molecular_function integral to membrane
YNL160W YNL160W YGP1 hom Verified 2.17769867910273 0.0147142386625125 no 137 0.0130482034518369 101 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p cell wall assembly molecular_function extracellular region
YJL188C_d YJL188C BUD19 hom Dubious 2.17591969794956 0.014780632811285 no 138 0.0130613226642443 140 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay Unknown Unknown Unknown
YOR191W YOR191W ULS1 hom Verified 2.17422357269152 0.0148441744407502 no 139 0.0131150790530381 150 NA FT CHROMATIN ORGANIZATION NUCLEUS|MITOCHONDRION Protein involved in proteolytic control of sumoylated substrates; contains RING finger domain; interacts with SUMO (Smt3p); member of the SWI/SNF family of DNA-dependent ATPases; plays a role in antagonizing silencing during mating-type switching; relocalizes from nucleus to cytoplasm upon DNA replication stress chromatin assembly or disassembly|mating type switching SUMO binding|DNA-dependent ATPase activity mitochondrion|nucleolus|nucleus
YLR372W YLR372W SUR4 hom Verified 2.16201510334996 0.0153085060236756 no 140 0.118597194012328 503 NA FF|FT VESICLE-MEDIATED TRANSPORT|KETONE METABOLISM|LIPID METABOLISM ENDOPLASMIC RETICULUM Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis post-Golgi vesicle-mediated transport|fatty acid elongation|fatty acid biosynthetic process|sphingolipid biosynthetic process fatty acid elongase activity integral to membrane|endoplasmic reticulum
YML051W YML051W GAL80 hom Verified 2.16057339132467 0.0153641543479713 no 141 0.0189381990179161 83 NA FT TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM NUCLEUS Transcriptional regulator involved in the repression of GAL genes in the absence of galactose; inhibits transcriptional activation by Gal4p; inhibition relieved by Gal3p or Gal1p binding negative regulation of kinase activity|galactose metabolic process|negative regulation of transcription from RNA polymerase II promoter|negative regulation of sequence-specific DNA binding transcription factor activity RNA polymerase II activating transcription factor binding|kinase inhibitor activity nucleus|cytoplasm
YDR014W YDR014W RAD61 hom Verified 2.15774170278874 0.0154739598351658 no 142 0.0243049041791248 129 NA FT CELL CYCLE|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Subunit of a complex (Scc3p, Pds5p, Rad61p) that inhibits sister chromatid cohesion; inhibited by Eco1p-acetylated cohesin subunits Smc3p and Mcd1p; related to the human Wapl protein that controls the association of cohesin with chromatin mitotic sister chromatid cohesion molecular_function nuclear cohesin complex
YNL259C YNL259C ATX1 hom Verified 2.15736238398685 0.0154887198687742 no 143 0.0180827545286165 150 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake copper ion transport|cellular response to oxidative stress|cellular iron ion homeostasis copper chaperone activity cytosol
YNL107W YNL107W YAF9 hom Verified 2.15547714625945 0.0155622575623771 no 144 0.0294678574853092 249 NA FF|FT CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING NUCLEUS|CHROMOSOME HISTONE ACETYLTRANSFERASE Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex, may function to antagonize silencing near telomeres; interacts directly with Swc4p, has homology to human leukemogenic protein AF9, contains a YEATS domain DNA repair|chromatin remodeling|histone exchange|chromatin silencing at telomere molecular_function Swr1 complex|nucleus|NuA4 histone acetyltransferase complex|cytoplasm
YOR246C YOR246C ENV9 hom Verified 2.14231960755284 0.0160838860393498 no 145 0.020648115867058 228 NA FF|FT OXIDATION-REDUCTION PROCESS|VACUOLAR PROTEIN PROCESSING Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts vacuole organization|vacuolar protein processing oxidoreductase activity lipid particle
YPL111W YPL111W CAR1 hom Verified 2.13205437978529 0.0165011881834007 no 146 0.0197632459606843 143 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS|SITE OF POLARIZED GROWTH Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance regulation of ornithine metabolic process|arginine catabolic process to ornithine manganese ion binding|arginase activity|ornithine carbamoyltransferase inhibitor activity|zinc ion binding cytosol|nucleus|mating projection tip|cytoplasm
YPR066W YPR066W UBA3 hom Verified 2.12783471231843 0.0166753951073262 no 147 0.0212218739118251 128 NA Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern protein neddylation NEDD8 activating enzyme activity cytoplasm
YMR265C_p YMR265C YMR265C hom Uncharacterized 2.1171975763918 0.0171215415061816 no 148 0.0169545058150986 144 NA Putative protein of unknown function biological_process molecular_function cellular_component
YJR120W YJR120W YJR120W hom Verified 2.11385851463135 0.0172636767125527 no 149 0.0164218887885116 101 NA FT OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p cellular respiration|sterol transport|mitochondrion organization molecular_function cellular_component
YPR159W YPR159W KRE6 hom Verified 2.1118549592596 0.0173494458139437 no 150 0.0323741410061034 158 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Type II integral membrane protein required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; localizes to the ER, plasma membrane, sites of polarized growth and secretory vesicles; functionally redundant with Skn1p fungal-type cell wall organization|(1->6)-beta-D-glucan biosynthetic process glucosidase activity integral to endoplasmic reticulum membrane|integral to membrane|site of polarized growth|transport vesicle|plasma membrane
YDR181C YDR181C SAS4 hom Verified 2.11073530696247 0.0173975347218158 no 151 0.0308220304820424 180 NA FT CHROMATIN ORGANIZATION|PROTEOLYSIS|GENE SILENCING NUCLEUS|CHROMOSOME HISTONE ACETYLTRANSFERASE Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p chromatin silencing at telomere acetyltransferase activity|histone acetyltransferase activity nuclear chromatin|SAS acetyltransferase complex|nuclear chromosome, telomeric region
YGR212W YGR212W SLI1 hom Verified 2.10418331746713 0.0176812295944001 no 152 0.0196523477880853 124 NA FT ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin response to drug N-acetyltransferase activity nuclear envelope|plasma membrane
YDR469W YDR469W SDC1 hom Verified 2.09582571779876 0.0180488270423676 no 153 0.0303207486683155 191 NA FT CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS Subunit of the COMPASS (Set1C) complex, which methylates lysine 4 of histone H3 and is required in chromatin silencing at telomeres; contains a Dpy-30 domain that mediates interaction with Bre2p; similar to C. elegans and human DPY-30 histone H3-K4 methylation|chromatin silencing at telomere histone methyltransferase activity (H3-K4 specific) Set1C/COMPASS complex
YCL032W YCL032W STE50 hom Verified 2.09180267965128 0.0182280852834456 no 154 0.0235807191083938 159 NA FT CELL CYCLE|SIGNALING Protein involved in mating response, invasive/filamentous growth, and osmotolerance, acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction pheromone-dependent signal transduction involved in conjugation with cellular fusion|MAPK cascade involved in osmosensory signaling pathway|osmosensory signaling pathway via Sho1 osmosensor|signal transduction involved in filamentous growth|cellular response to heat SAM domain binding|protein kinase regulator activity cytoplasm
YPL269W YPL269W KAR9 hom Verified 2.08046594338184 0.0187414081222449 no 155 0.0334251795633208 224 NA FT NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase nuclear migration along microtubule|establishment of spindle localization molecular_function cell cortex|spindle pole body|mating projection tip
YJL103C YJL103C GSM1 hom Verified 2.06494208625819 0.0194642401623258 no 156 0.0219646852643521 133 NA FT TRANSCRIPTION FROM RNA POL II|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis oxidative phosphorylation sequence-specific DNA binding|DNA binding cellular_component
YPR009W YPR009W SUT2 hom Verified 2.05603084769544 0.0198897714531715 no 157 0.0253388618244563 126 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1p positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter RNA polymerase II repressing transcription factor binding|sequence-specific DNA binding nucleus
YOR337W YOR337W TEA1 hom Verified 2.05050695399575 0.0201574929466875 no 158 0.020988846932873 171 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Ty1 enhancer activator required for full levels of Ty enhancer-mediated transcription; C6 zinc cluster DNA-binding protein transcription, DNA-dependent sequence-specific DNA binding|DNA binding nucleus
YDR123C YDR123C INO2 hom Verified 2.04649013960742 0.0203540858075943 no 159 0.0249560710598499 164 NA FT TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM NUCLEUS Component of the heteromeric Ino2p/Ino4p basic helix-loop-helix transcription activator that binds inositol/choline-responsive elements (ICREs), required for derepression of phospholipid biosynthetic genes in response to inositol depletion phospholipid biosynthetic process|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YDR514C YDR514C YDR514C hom Verified 2.04256431558895 0.0205477933030651 no 160 0.017769924879456 147 NA FT NUCLEUS|MITOCHONDRION Protein of unknown function that localizes to mitochondria; overexpression affects endocytic protein trafficking; YDR514C has a paralog, GFD2, that arose from the whole genome duplication biological_process molecular_function mitochondrion|nucleus
YBR028C YBR028C YPK3 hom Verified 2.04054634180319 0.0206479701541515 no 161 0.0316335732265059 171 NA FT PROTEIN PHOSPHORYLATION An AGC kinase phosphorylated by cAMP-dependent protein kinase (PKA) in a TORC1-dependent manner biological_process protein kinase activity cytoplasm
YGR068C YGR068C ART5 hom Verified 2.02690893940446 0.0213358630720416 no 162 0.0219201410001642 137 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION Protein proposed to regulate the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membrane ubiquitin-dependent endocytosis ubiquitin protein ligase binding cellular_component
YPL223C YPL223C GRE1 hom Verified 2.02135581690232 0.0216214724784697 no 163 0.0271636716347287 122 NA Hydrophilin essential in dessication-rehydration process; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway biological_process molecular_function cytoplasm
YDR408C YDR408C ADE8 hom Verified 2.01938754252276 0.0217234776578863 no 164 0.0262459589509677 142 NA FT NUCLEOTIDE METABOLISM NUCLEUS Phosphoribosyl-glycinamide transformylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway purine nucleotide biosynthetic process|'de novo' IMP biosynthetic process|adenine biosynthetic process phosphoribosylglycinamide formyltransferase activity nucleus|cytoplasm
YLR001C_p YLR001C YLR001C hom Uncharacterized 2.01703882230217 0.0218457310432562 no 165 0.0175103970907831 134 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; predicted to be palmitoylated biological_process molecular_function mitochondrion|fungal-type vacuole membrane
YDR171W YDR171W HSP42 hom Verified 2.01665991830065 0.0218655077273495 no 166 0.0129911774706735 84 NA FT CYTOSKELETON ORGANIZATION CYTOSKELETON Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress cytoskeleton organization unfolded protein binding cytoskeleton|chaperonin-containing T-complex|cytoplasm
YBL054W YBL054W TOD6 hom Verified 2.00995325534188 0.0222180682368521 no 167 0.0230251441069782 121 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS|CHROMOSOME PAC motif binding protein involved in rRNA and ribosome biogenesis; subunit of the RPD3L histone deacetylase complex; Myb-like HTH transcription factor; hypophosphorylated by rapamycin treatment in a Sch9p-dependent manner; TOD6 has a paralog, DOT6, that arose from the whole genome duplication regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding Rpd3L-Expanded complex|nucleus|Rpd3L complex|cytoplasm
YLR454W_p YLR454W FMP27 hom Uncharacterized 2.00751881179937 0.0223472248178836 no 168 0.0180979966544385 161 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YGR025W_d YGR025W YGR025W hom Dubious 2.00028283400334 0.0227348657853768 no 169 0.0110550676693759 75 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YBR300C_d YBR300C YBR300C hom Dubious 1.99544406266943 0.0229972346298124 no 170 0.0345147773714209 196 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR301W; YBR300C is not an essential gene Unknown Unknown Unknown
YPL104W YPL104W MSD1 hom Verified 1.99377014759726 0.0230885896812481 no 171 0.0380293255022645 224 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial aspartyl-tRNA synthetase, required for acylation of aspartyl-tRNA; yeast and bacterial aspartyl-, asparaginyl-, and lysyl-tRNA synthetases contain regions with high sequence similarity, suggesting a common ancestral gene mitochondrial aspartyl-tRNA aminoacylation aspartate-tRNA ligase activity mitochondrion
YOR193W YOR193W PEX27 hom Verified 1.99369249615799 0.0230928349675432 no 172 0.02075601534038 134 NA FT PEROXISOME ORGANIZATION Peripheral peroxisomal membrane protein involved in controlling peroxisome size and number, interacts with homologous protein Pex25p peroxisome organization molecular_function peroxisomal membrane
YAL024C YAL024C LTE1 hom Verified 1.98491913235523 0.0235767346946266 no 173 0.0584652301637401 292 NA FF|FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|SIGNALING|CELL DIVISION Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures regulation of exit from mitosis|mitotic cell cycle spindle orientation checkpoint|vesicle-mediated transport guanyl-nucleotide exchange factor activity cellular bud
YHL013C YHL013C OTU2 hom Verified 1.98251369053041 0.0237108883266056 no 174 0.0176073476367772 140 NA Protein of unknown function; may interact with ribosomes, based on co-purification experiments; member of the ovarian tumor-like (OTU) superfamily of predicted cysteine proteases; shows cytoplasmic localization; protein abundance increases in response to DNA replication stress biological_process molecular_function ribosome|cytoplasm
YLR173W_p YLR173W YLR173W hom Uncharacterized 1.97338526249095 0.0242258426971457 no 175 0.0243645631662566 131 NA Putative protein of unknown function biological_process molecular_function cellular_component
YMR171C YMR171C EAR1 hom Verified 1.96309758212528 0.024817418228327 no 176 0.022298260273948 140 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT Specificity factor required for Rsp5p-dependent ubiquitination and sorting of specific cargo proteins at the multivesicular body; mRNA is targeted to the bud via the mRNA transport system involving She2p protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway molecular_function endosome
YLR094C YLR094C GIS3 hom Verified 1.95691464597485 0.0251787521611418 no 177 0.0376100902159903 157 NA FT SIGNALING NUCLEUS Protein of unknown function intracellular signal transduction molecular_function nucleus|cytoplasm
YOR355W YOR355W GDS1 hom Verified 1.9548712451813 0.0252991346529711 no 178 0.0324595023607407 229 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS|MITOCHONDRION Protein of unknown function, required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies aerobic respiration molecular_function mitochondrion|nucleus|cytoplasm
YIL043C YIL043C CBR1 hom Verified 1.94596758284841 0.0258293168699304 no 179 0.0311468148673839 205 NA FT OXIDATION-REDUCTION PROCESS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION Microsomal cytochrome b reductase, not essential for viability; also detected in mitochondria; mutation in conserved NADH binding domain of the human ortholog results in type I methemoglobinemia biological_process cytochrome-b5 reductase activity mitochondrial outer membrane|mitochondrion
YMR022W YMR022W UBC7 hom Verified 1.93572866464925 0.0264504708967848 no 180 0.0376047059562452 186 NA FT CHROMATIN ORGANIZATION|CELL WALL ORG/BIOGENESIS|PROTEOLYSIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly fungal-type cell wall organization|chromatin assembly or disassembly|ER-associated protein catabolic process ubiquitin-protein ligase activity endoplasmic reticulum membrane
YKR088C YKR088C TVP38 hom Verified 1.92825779269635 0.0269115344543661 no 181 0.0276733527171878 202 NA FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|CYTOSKELETON ORGANIZATION ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; required for asymmetric localization of Kar9p during mitosis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern vesicle-mediated transport|mitotic spindle elongation molecular_function integral to membrane|integral to Golgi membrane|cytoplasm
YLR421C YLR421C RPN13 hom Verified 1.92313089527098 0.0272318065856156 no 182 0.0315357215751985 145 NA FT PROTEOLYSIS NUCLEUS Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; protein abundance increases in response to DNA replication stress ubiquitin-dependent protein catabolic process ubiquitin binding proteasome storage granule|proteasome regulatory particle, lid subcomplex
YDR442W_d YDR442W YDR442W hom Dubious 1.92309841059108 0.0272338459640514 no 183 0.0460136308494619 203 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOR178C YOR178C GAC1 hom Verified 1.92265534406854 0.0272616742690656 no 184 0.0282031579953585 166 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock meiosis|glycogen metabolic process|negative regulation of transcription from RNA polymerase II promoter|response to heat|mitotic cell cycle spindle assembly checkpoint protein phosphatase type 1 regulator activity|structural molecule activity|heat shock protein binding protein phosphatase type 1 complex
YOR011W YOR011W AUS1 hom Verified 1.91842019747589 0.0275288760301666 no 185 0.0344469605380452 193 NA FT NUCLEOTIDE METABOLISM MITOCHONDRION|PLASMA MEMBRANE Plasma membrane sterol transporter of the ATP-binding cassette family; required, along with Pdr11p, for uptake of exogenous sterols and their incorporation into the plasma membrane; activity is stimulated by phosphatidylserine; sterol uptake is required for anaerobic growth because sterol biosynthesis requires oxygen sterol import sterol-transporting ATPase activity mitochondrion|integral to membrane|plasma membrane
YPR077C_d YPR077C YPR077C hom Dubious 1.90376817165071 0.0284701917387282 no 186 0.0283484389106015 189 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression increased by deletion of NAP1 Unknown Unknown Unknown
YLR404W YLR404W FLD1 hom Verified 1.90227133879975 0.0285678453207907 no 187 0.0303327149320475 149 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Seipin protein involved in lipid droplet morphology, number, and size; proposed to be involved in lipid metabolism; related to the human BSCL2 which is associated with lipodystrophy lipid particle organization molecular_function integral to membrane|endoplasmic reticulum|cortical endoplasmic reticulum
YKL011C YKL011C CCE1 hom Verified 1.89963321186032 0.0287406353061968 no 188 0.0338855871061967 209 NA FT MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial cruciform cutting endonuclease, cleaves Holliday junctions formed during recombination of mitochondrial DNA mitochondrial genome maintenance endodeoxyribonuclease activity mitochondrial inner membrane
YER068C-A_d YER068C-A YER068C-A hom Dubious 1.89809566625228 0.0288417404807772 no 189 0.0244309115713797 96 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOR265W YOR265W RBL2 hom Verified 1.88449928372793 0.0297487358024645 no 190 0.0389710158668044 197 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION CYTOSKELETON Protein involved in microtubule morphogenesis; required for protection from excess free beta-tubulin; proposed to be involved the folding of beta-tubulin; similar to mouse beta-tubulin cofactor A; protein abundance increases in response to DNA replication stress tubulin complex assembly|tubulin complex biogenesis tubulin binding|beta-tubulin binding cytoplasm
YOR141C YOR141C ARP8 hom Verified 1.88439415872648 0.0297558396878904 no 191 0.0341586001423866 246 NA FT CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME|CYTOSKELETON Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes; has mRNA binding activity mitotic recombination|response to DNA damage stimulus|chromatin remodeling mRNA binding|ATP-dependent 3'-5' DNA helicase activity nucleus|Ino80 complex
YIL001W_p YIL001W YIL001W hom Uncharacterized 1.88385688715808 0.0297921681198775 no 192 0.0391023546162377 181 NA Putative protein of unknown function; contains a BTB/POZ domain which generally function in protein interactions; deletion slightly improved competitive fitness in rich media; GFP-tagged protein is localized to the cytoplasm biological_process molecular_function cytoplasm
YKL150W YKL150W MCR1 hom Verified 1.88295282215236 0.0298533808941119 no 193 0.045662714299197 174 NA FT LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS MITOCHONDRION Mitochondrial NADH-cytochrome b5 reductase, involved in ergosterol biosynthesis ergosterol biosynthetic process|cellular response to oxidative stress cytochrome-b5 reductase activity mitochondrial outer membrane|mitochondrion|integral to mitochondrial outer membrane|mitochondrial intermembrane space
YPL198W YPL198W RPL7B hom Verified 1.88285377848208 0.0298600933166208 no 194 0.033871683438185 155 NA FT TRANSLATION NUCLEUS RIBOSOME Ribosomal 60S subunit protein L7B; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7B has a paralog, RPL7A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit|nucleolus|cytoplasm
YPR097W YPR097W YPR097W hom Verified 1.88283087320247 0.0298616458395273 no 195 0.0378868138615469 225 NA FT MITOCHONDRION Protein that contains a Phox homology (PX) domain and binds phosphoinositides; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process phosphatidylinositol binding mitochondrion
YMR121C YMR121C RPL15B hom Verified 1.88018895786185 0.0300411649855429 no 196 0.0230856940002281 136 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress cytoplasmic translation structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YBR170C YBR170C NPL4 hom Verified 1.8799951729862 0.030054367892626 no 197 0.0312545997720116 159 NA FT PROTEIN LOCALIZATION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM UBIQUITIN LIGASE COMPLEX Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; assists Cdc48p in the dislocation of misfolded, polyubiquitinated ERAD substrates that are subsequently delivered to the proteasome for degradation; also involved in the regulated destruction of resident ER membrane proteins, such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing (RUP) retrograde protein transport, ER to cytosol|proteasomal ubiquitin-dependent protein catabolic process|mitochondria-associated protein catabolic process|mitotic spindle disassembly|ER-associated protein catabolic process|ER-associated misfolded protein catabolic process|Unknown|cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process molecular_function Doa10p ubiquitin ligase complex|integral to membrane|Cdc48p-Npl4p-Ufd1p AAA ATPase complex|Cdc48p-Npl4p-Vms1p AAA ATPase complex|nuclear outer membrane-endoplasmic reticulum membrane network
YLR422W_p YLR422W YLR422W hom Uncharacterized 1.8796188632322 0.0300800202862814 no 198 0.0368465015645387 197 NA Protein of unknown function with similarity to human DOCK proteins (guanine nucleotide exchange factors); interacts with Ino4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, YLR422W is not an essential protein biological_process molecular_function cytoplasm
YGR100W YGR100W MDR1 hom Verified 1.8743882119568 0.030438468529494 no 199 0.0365276737805688 150 NA FT PROTEIN LOCALIZATION|SIGNALING|NUCLEOTIDE METABOLISM Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function intracellular protein transport Rab GTPase activator activity cytoplasm
YGR150C YGR150C CCM1 hom Verified 1.86383685312704 0.0311723093460392 no 200 0.0449006273083958 230 NA FT RNA PROCESSING|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial 15s rRNA-binding protein; required for intron removal of COB and COX1 pre-mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport rRNA metabolic process|mitochondrial RNA processing|mitochondrial genome maintenance rRNA binding mitochondrion
YPR092W_d YPR092W YPR092W hom Dubious 1.85781861901434 0.0315973880808464 no 201 0.037860687181469 176 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YJL096W YJL096W MRPL49 hom Verified 1.85683563986115 0.0316672707335322 no 202 0.0469568852968967 209 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YER083C YER083C GET2 hom Verified 1.85211874815351 0.032004386442515 no 203 0.0899389259970231 440 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for meiotic nuclear division retrograde vesicle-mediated transport, Golgi to ER|protein insertion into ER membrane protein anchor integral to membrane|endoplasmic reticulum|GET complex
YNL243W YNL243W SLA2 hom Verified 1.85203365284683 0.0320104953028097 no 204 0.0305690710484041 146 NA FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON Adaptor protein that links actin to clathrin and endocytosis; involved in membrane cytoskeleton assembly and cell polarization; present in the actin cortical patch of the emerging bud tip; dimer in vivo bipolar cellular bud site selection|fungal-type cell wall organization|actin filament organization|endocytosis|exocytosis protein binding, bridging incipient cellular bud site|mating projection tip|actin cortical patch
YLL014W YLL014W EMC6 hom Verified 1.85072705582372 0.0321044148350186 no 205 0.0457451805771255 248 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93 protein folding in endoplasmic reticulum molecular_function ER membrane protein complex|integral to membrane|endoplasmic reticulum
YER111C YER111C SWI4 hom Verified 1.85034743922882 0.0321317446768267 no 206 0.0352947639340607 243 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE NUCLEUS|CHROMOSOME DNA binding component of the SBF complex (Swi4p-Swi6p); a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair; acetylation at two sites, K1016 and K1066, regulates interaction with Swi6p positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription involved in G1/S phase of mitotic cell cycle sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription SBF transcription complex|nuclear chromatin
YDR483W YDR483W KRE2 hom Verified 1.8458592621356 0.0324563215490495 no 207 0.0608846944552322 245 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Alpha1,2-mannosyltransferase of the Golgi; involved in protein mannosylation; KRE2 has a paralog, KTR6, that arose from the whole genome duplication N-glycan processing|cell wall mannoprotein biosynthetic process|protein O-linked glycosylation alpha-1,2-mannosyltransferase activity Golgi apparatus
YKL176C YKL176C LST4 hom Verified 1.84564906462105 0.0324715887208546 no 208 0.0465138368948548 228 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface intracellular protein transport|vesicle-mediated transport|protein transport|Golgi to plasma membrane transport protein transporter activity vesicle coat
YDR115W YDR115W YDR115W hom Verified 1.84469717365157 0.0325408011278341 no 209 0.0305800508765835 167 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Putative mitochondrial ribosomal protein of the large subunit; similar to E. coli L34 ribosomal protein; required for respiratory growth, as are most mitochondrial ribosomal proteins; protein increases in abundance and relocalizes to the plasma membrane upon DNA replication stress mitochondrial translation structural constituent of ribosome mitochondrial large ribosomal subunit
YML081W YML081W TDA9 hom Verified 1.84134601201293 0.032785434491527 no 210 0.0300263959541179 174 NA FT NUCLEUS DNA-binding protein, putative transcription factor; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; TDA9 has a paralog, RSF2, that arose from the whole genome duplication biological_process sequence-specific DNA binding nucleus
YIL076W YIL076W SEC28 hom Verified 1.84132801684498 0.0327867522125427 no 211 0.0306236091328555 186 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth; protein abundance increases in response to DNA replication stress late endosome to vacuole transport via multivesicular body sorting pathway|ER to Golgi vesicle-mediated transport|vesicle coating molecular_function endosome|COPI vesicle coat
YMR304W YMR304W UBP15 hom Verified 1.83894501338432 0.0329616370636319 no 212 0.0544526601867773 177 NA FT PROTEOLYSIS Ubiquitin-specific protease involved in protein deubiquitination; catalytic activity regulated by an N-terminal TRAF-like domain and and C-terminal sequences; physically interacts with anaphase-promoting complex/cyclosome (APC/C) activator, Cdh1p; forms a complex with AAA peroxins Pex1p and Pex6p protein deubiquitination ubiquitin-specific protease activity peroxisome|cytoplasm
YGL200C YGL200C EMP24 hom Verified 1.83741713249278 0.0330741697681085 no 213 0.0340890272952816 217 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles protein retention in ER lumen|vesicle organization|ER to Golgi vesicle-mediated transport molecular_function integral to membrane|endoplasmic reticulum|ER to Golgi transport vesicle
YLR136C YLR136C TIS11 hom Verified 1.83550772173432 0.0332152480143211 no 214 0.0253225641415008 149 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS NUCLEUS mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress cellular iron ion homeostasis|nuclear-transcribed mRNA catabolic process mRNA binding nucleus|cytoplasm
YCR075W-A_p YCR075W-A YCR075W-A hom Uncharacterized 1.82927420538191 0.0336792704191498 no 215 0.0351279362269828 203 NA Putative protein of unknown function; identified by homology to Ashbya gossypii; YCR075W-A has a paralog, YNR034W-A, that arose from the whole genome duplication biological_process molecular_function cellular_component
YER186C_p YER186C YER186C hom Uncharacterized 1.8280903451159 0.0337679968621098 no 216 0.0349897381630837 204 NA Putative protein of unknown function biological_process molecular_function cellular_component
YPR015C_p YPR015C YPR015C hom Uncharacterized 1.82486138744141 0.034010974666523 no 217 0.0396944647877756 154 NA Putative protein of unknown function; overexpression causes a cell cycle delay or arrest biological_process sequence-specific DNA binding cellular_component
YOR127W YOR127W RGA1 hom Verified 1.82476343363948 0.03401836806319 no 218 0.0338777560540787 186 NA FT SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON GTPase-activating protein for polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; relocalizes from bud neck to cytoplasm upon DNA replication stress budding cell isotropic bud growth|pheromone-dependent signal transduction involved in conjugation with cellular fusion|pseudohyphal growth|actin filament organization|establishment of cell polarity|small GTPase mediated signal transduction|invasive growth in response to glucose limitation|budding cell apical bud growth Rho GTPase activator activity cellular bud neck split septin rings
YLR416C_d YLR416C YLR416C hom Dubious 1.82384101242321 0.0340880557901657 no 219 0.0304563407457742 156 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YEL072W YEL072W RMD6 hom Verified 1.82034856527345 0.0343529699622548 no 220 0.0357159006219026 179 NA FT CELL CYCLE Protein required for sporulation biological_process molecular_function cellular_component
YLR040C_p YLR040C YLR040C hom Uncharacterized 1.81937992720958 0.0344267434665555 no 221 0.0384065170509074 204 NA Protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; mRNA identified as translated by ribosome profiling data; YLR040C is not essential biological_process molecular_function fungal-type cell wall
YDR244W YDR244W PEX5 hom Verified 1.81791264699999 0.034538742504723 no 222 0.0490063450495204 171 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PEROXISOME ORGANIZATION Peroxisomal membrane signal receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions protein import into peroxisome matrix, docking peroxisome matrix targeting signal-1 binding|protein binding, bridging cytosol|peroxisomal membrane|peroxisome
YFL046W_p YFL046W FMP32 hom Uncharacterized 1.8123263140287 0.0349678954791711 no 223 0.0278737286494445 140 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YBL008W YBL008W HIR1 hom Verified 1.81029512875485 0.0351250160337978 no 224 0.0397757567578467 196 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores DNA replication-independent nucleosome assembly|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter nucleosome binding|transcription corepressor activity|DNA binding chromosome, centromeric region|HIR complex|nucleus
YGR049W YGR049W SCM4 hom Verified 1.80980302210514 0.0351631695576856 no 225 0.0396926052271277 134 NA FT MITOCHONDRION Mitochondrial outer membrane protein of unknown function; predicted to have 4 transmembrane segments; import is mediated by Tom70p and Mim1p; interacts genetically with a cdc4 mutation biological_process molecular_function mitochondrial outer membrane|mitochondrion|integral to membrane
YIL035C YIL035C CKA1 hom Verified 1.80788454223295 0.0353122360284928 no 226 0.0428369572634688 241 NA FT RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION NUCLEUS Alpha catalytic subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; regulates Fkh1p-mediated donor preference during mating-type switching regulation of transcription from RNA polymerase I promoter|protein phosphorylation|regulation of transcription from RNA polymerase III promoter|response to DNA damage stimulus protein serine/threonine kinase activity|protein kinase activity protein kinase CK2 complex|UTP-C complex
YKR059W YKR059W TIF1 hom Verified 1.80491987128786 0.0355436108859505 no 227 0.0344342386998301 187 NA FT TRANSLATION RIBOSOME Translation initiation factor eIF4A; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; protein abundance increases in response to DNA replication stress; TIF1 has a paralog, TIF2, that arose from the whole genome duplication translational initiation ATP-dependent RNA helicase activity|translation initiation factor activity ribosome|eukaryotic translation initiation factor 4F complex
YHR021W-A_p YHR021W-A ECM12 hom Uncharacterized 1.80457244259788 0.0355708067952309 no 228 0.0297790032444492 157 NA FT CELL WALL ORG/BIOGENESIS Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity fungal-type cell wall organization molecular_function cellular_component
YLR412C-A_p YLR412C-A YLR412C-A hom Uncharacterized 1.80403625688698 0.0356128116405846 no 229 0.0342802995540546 175 NA Putative protein of unknown function biological_process molecular_function cellular_component
YGL231C YGL231C EMC4 hom Verified 1.79820392909576 0.0360723485806248 no 230 0.0501954918832635 213 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm ZK616.6/EMC-4, fly CG11137, human TMM85 protein folding in endoplasmic reticulum molecular_function ER membrane protein complex|endoplasmic reticulum
YNR023W YNR023W SNF12 hom Verified 1.79652564587408 0.0362054788738486 no 231 0.119817306911581 436 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS NUCLEUS RSC COMPLEX 73 kDa subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; homolog of Rsc6p subunit of the RSC chromatin remodeling complex; relocates to the cytosol under hypoxic conditions; deletion mutants are temperature-sensitive positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation|positive regulation of transcription from RNA polymerase II promoter molecular_function SWI/SNF complex
YKL169C_d YKL169C YKL169C hom Dubious 1.79287489724867 0.0364964650310201 no 232 0.0734949710622246 312 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL38 Unknown Unknown Unknown
YJL210W YJL210W PEX2 hom Verified 1.7927929506888 0.0365030185493429 no 233 0.0310075970993478 164 NA FT PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION RING-finger peroxin and E3 ubiquitin ligase, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import protein import into peroxisome matrix ubiquitin-protein ligase activity|protein binding peroxisomal membrane
YPL006W YPL006W NCR1 hom Verified 1.79101737166475 0.0366452536836204 no 234 0.0365319187200608 195 NA FT LIPID METABOLISM Vacuolar membrane protein that transits through the biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism; glycoprotein and functional orthologue of human Niemann Pick C1 (NPC1) protein sphingolipid metabolic process sphingolipid transporter activity fungal-type vacuole membrane|integral to membrane
YMR062C YMR062C ARG7 hom Verified 1.78969078734759 0.0367518171247013 no 235 0.0555336197932941 287 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS MITOCHONDRION Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine fungal-type cell wall organization|ornithine biosynthetic process|arginine biosynthetic process acetyl-CoA:L-glutamate N-acetyltransferase activity|glutamate N-acetyltransferase activity mitochondrion|mitochondrial matrix
YLR036C_p YLR036C YLR036C hom Uncharacterized 1.78817596060796 0.0368738117168407 no 236 0.0303799748980925 198 NA Putative protein of unknown function predicted to have transmembrane domains; interacts with HSP90 by yeast two-hybrid analysis; YLR036C is not an essential protein biological_process molecular_function integral to membrane
YKL198C YKL198C PTK1 hom Verified 1.7875682551535 0.0369228454492711 no 237 0.0428769621443086 197 NA FT PROTEIN PHOSPHORYLATION Putative serine/threonine protein kinase that regulates spermine uptake; involved in polyamine transport; possible mitochondrial protein polyamine transport protein kinase activity cellular_component
YML017W YML017W PSP2 hom Verified 1.78489220316048 0.0371394017915605 no 238 0.0514735882512536 272 NA Asn rich cytoplasmic protein that contains RGG motifs; high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha); possible role in mitochondrial mRNA splicing biological_process molecular_function cytoplasm
YDL037C YDL037C BSC1 hom Verified 1.78188921449297 0.0373836498569302 no 239 0.0413113109114221 211 NA Protein of unconfirmed function, similar to cell surface flocculin Flo11p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression biological_process molecular_function cellular_component
YGR177C YGR177C ATF2 hom Verified 1.78140508716636 0.0374231488881929 no 240 0.0265421539311253 142 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Alcohol acetyltransferase, may play a role in steroid detoxification; forms volatile esters during fermentation, which is important for brewing and winemaking steroid metabolic process|response to toxin|Unknown|sterol acetylation alcohol O-acetyltransferase activity integral to endoplasmic reticulum membrane|endoplasmic reticulum|cytoplasm
YGR187C YGR187C HGH1 hom Verified 1.78012845010195 0.0375274707638847 no 241 0.0351578488098968 204 NA Nonessential protein of unknown function; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16); relative distribution to the nucleus increases upon DNA replication stress biological_process molecular_function cytoplasm
YOR192C YOR192C THI72 hom Verified 1.77938192286664 0.0375885840539297 no 242 0.0418167274807197 235 NA Transporter of thiamine or related compound; shares sequence similarity with Thi7p thiamine transport transporter activity integral to membrane|membrane
YJL132W_p YJL132W YJL132W hom Uncharacterized 1.77289118761842 0.0381233695958608 no 243 0.0331172522728548 178 NA Putative protein of unknown function; localizes to the membrane fraction; possible Zap1p-regulated target gene induced by zinc deficiency; YJL132W is a non-essential gene biological_process molecular_function membrane
YLR095C YLR095C IOC2 hom Verified 1.77269202643918 0.0381398765354256 no 244 0.0364011269924814 193 NA FT CHROMATIN ORGANIZATION NUCLEUS Member of a complex (Isw1b) with Isw1p and Ioc4p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PHD finger motif chromatin remodeling protein binding|nucleosome binding|ATPase activity|DNA binding ISW1 complex
YCL021W-A_p YCL021W-A YCL021W-A hom Uncharacterized 1.77261269242435 0.038146453545519 no 245 0.024627251356693 129 NA Putative protein of unknown function biological_process molecular_function cellular_component
YKR030W YKR030W GMH1 hom Verified 1.76657748581157 0.0386495071231547 no 246 0.0265725342524021 176 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Golgi membrane protein of unknown function, interacts with Gea1p and Gea2p; required for localization of Gea2p; computational analysis suggests a possible role in either cell wall synthesis or protein-vacuolar targeting transport molecular_function integral to membrane|integral to Golgi membrane
YOR113W YOR113W AZF1 hom Verified 1.76537246362768 0.0387505940738993 no 247 0.0488743375661837 212 NA FT TRANSCRIPTION FROM RNA POL II|CELL WALL ORG/BIOGENESIS NUCLEUS Zinc-finger transcription factor; in the presence of glucose, activates transcription of genes involved in growth and carbon metabolism; in nonfermentable carbon sources, activates transcription of genes involved in maintenance of cell wall integrity regulation of fungal-type cell wall organization|regulation of transcription from RNA polymerase II promoter|cellular response to carbohydrate stimulus RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YHL026C_p YHL026C YHL026C hom Uncharacterized 1.76183238234541 0.0390488108869425 no 248 0.0435956711106907 207 NA Putative protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History) biological_process molecular_function cellular_component
YLR262C YLR262C YPT6 hom Verified 1.76028764302546 0.0391795241302804 no 249 0.134113211198376 471 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING GOLGI APPARATUS|PLASMA MEMBRANE Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6 intracellular protein transport|retrograde transport, endosome to Golgi GTPase activity Golgi apparatus
YHR094C YHR094C HXT1 hom Verified 1.75614965942241 0.0395314288449098 no 250 0.0385586523028705 211 NA FT PLASMA MEMBRANE Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting; HXT1 has a paralog, HXT6, what arose from the whole genome duplication mannose transport|glucose transport galactose transmembrane transporter activity|pentose transmembrane transporter activity|mannose transmembrane transporter activity|glucose transmembrane transporter activity|fructose transmembrane transporter activity integral to membrane|plasma membrane
YLR124W_d YLR124W YLR124W hom Dubious 1.75435835803438 0.0396845609674129 no 251 0.0416406707291281 194 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YMR102C_p YMR102C YMR102C hom Uncharacterized 1.75311840639453 0.0397908423469317 no 252 0.0341271017236584 219 NA Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene biological_process molecular_function cellular_component
YPR020W YPR020W ATP20 hom Verified 1.75280672295006 0.0398175943852786 no 253 0.03787706682319 212 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS MITOCHONDRION Subunit g of the mitochondrial F1F0 ATP synthase; reversibly phosphorylated on two residues; unphosphorylated form is required for dimerization of the ATP synthase complex protein oligomerization|cristae formation|protein complex assembly|ATP synthesis coupled proton transport structural molecule activity|proton-transporting ATPase activity, rotational mechanism mitochondrion|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
YMR319C YMR319C FET4 hom Verified 1.74756148898014 0.0402699943912834 no 254 0.0930769724332147 415 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Low-affinity Fe(II) transporter of the plasma membrane intracellular copper ion transport|zinc ion transport|low-affinity iron ion transport|copper ion import copper ion transmembrane transporter activity|iron ion transmembrane transporter activity integral to membrane|plasma membrane|integral to plasma membrane
YMR279C YMR279C YMR279C hom Verified 1.7473612058996 0.0402873511617403 no 255 0.054786822091945 256 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Putative boron transporter involved in boron efflux and resistance; overexpression mutant but not null mutant displays boron tolerance phenotype; identified as a heat-induced gene in a high-throughout screen; YMR279C is not an essential gene; YMR279C has a paralog, ATR1, that arose from the whole genome duplication borate transmembrane transport borate efflux transmembrane transporter activity integral to membrane
YAL042C-A_d YAL042C-A YAL042C-A hom Dubious 1.74656735941903 0.0403562066208115 no 256 0.0405706703918288 196 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF ERV46/YAL042W; YAL042C-A is a non-essential gene Unknown Unknown Unknown
YMR085W_p YMR085W YMR085W hom Uncharacterized 1.74580181030347 0.0404226981520053 no 257 0.0433811663436448 220 NA FT CARBOHYDRATE METABOLISM Putative protein of unknown function; YMR085W and adjacent ORF YMR084W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1 biological_process molecular_function cellular_component
YLR443W YLR443W ECM7 hom Verified 1.7441911476931 0.0405628822107604 no 258 0.0405532691656072 228 NA FT ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency fungal-type cell wall organization|calcium ion transport molecular_function integral to membrane
YMR020W YMR020W FMS1 hom Verified 1.74383038991065 0.0405943348049978 no 259 0.0215765890683064 132 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis pantothenate biosynthetic process|polyamine catabolic process polyamine oxidase activity cytoplasm
YNR027W YNR027W BUD17 hom Verified 1.74337391300524 0.0406341610199026 no 260 0.0479431225341386 221 NA FT CELL CYCLE|CELL DIVISION|COFACTOR METABOLISM NUCLEUS Putative pyridoxal kinase, a key enzyme in vitamin B6 metabolism; involved in bud-site selection; diploid mutants display a random rather than a bipolar budding pattern; similarity to yeast BUD16 and human pyridoxal kinase (PDXK) pyridoxal phosphate biosynthetic process|cellular bud site selection pyridoxal kinase activity nucleus|cytoplasm
YHR204W YHR204W MNL1 hom Verified 1.74057372120421 0.0408791636476356 no 261 0.0366936403893977 239 NA FT PROTEOLYSIS ENDOPLASMIC RETICULUM Alpha-1,2-specific exomannosidase of the endoplasmic reticulum; in complex with Pdi1p, generates a Man7GlcNac2 oligosaccharide signal on glycoproteins destined for ubiquitin-proteasome degradation ER-associated protein catabolic process carbohydrate binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity endoplasmic reticulum lumen
YNL179C_d YNL179C YNL179C hom Dubious 1.73689443262699 0.0412029031553633 no 262 0.0411465902589521 226 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance Unknown Unknown Unknown
YPL254W YPL254W HFI1 hom Verified 1.73513375566796 0.0413585582938237 no 263 0.0522513754682111 269 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS HISTONE ACETYLTRANSFERASE Adaptor protein required for structural integrity of the SAGA complex, a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions histone acetylation|chromatin modification|transcription from RNA polymerase II promoter transcription coactivator activity|transcription cofactor activity SLIK (SAGA-like) complex|Ada2/Gcn5/Ada3 transcription activator complex|SAGA complex
YJR005W YJR005W APL1 hom Verified 1.73467344398453 0.0413993312925698 no 264 0.0432631846912571 221 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|PLASMA MEMBRANE Beta-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport; similar to mammalian beta-chain of the clathrin associated protein complex vesicle-mediated transport molecular_function AP-2 adaptor complex
YBL070C_d YBL070C YBL070C hom Dubious 1.73461712174643 0.0414043223799031 no 265 0.0470221861360052 182 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR025W YLR025W SNF7 hom Verified 1.73383239559116 0.041473912915246 no 266 0.108584925481052 494 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes cellular response to anoxia|intralumenal vesicle formation|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|late endosome to vacuole transport protein binding ESCRT III complex|cytoplasm
YMR219W YMR219W ESC1 hom Verified 1.73095575022434 0.0417298284981729 no 267 0.0492756065612587 227 NA FT GENE SILENCING NUCLEUS Protein localized to the nuclear periphery, involved in telomeric silencing; interacts with PAD4-domain of Sir4p chromatin silencing at telomere molecular_function nuclear periphery
YLL052C YLL052C AQY2 hom Verified 1.7274081158172 0.0420471970516513 no 268 0.0502086326170045 220 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains water transport water channel activity plasma membrane|endoplasmic reticulum membrane
YKL029C YKL029C MAE1 hom Verified 1.71408958366666 0.0432561372640508 no 269 0.037663701683986 252 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION Mitochondrial malic enzyme, catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids pyruvate metabolic process|cellular amino acid metabolic process malic enzyme activity mitochondrion
YLR114C YLR114C AVL9 hom Verified 1.71406387168863 0.0432584980365773 no 270 0.0497974034994008 198 NA FT VESICLE-MEDIATED TRANSPORT Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress post-Golgi vesicle-mediated transport molecular_function cytoplasm
YHR117W YHR117W TOM71 hom Verified 1.71066473705521 0.0435715104346389 no 271 0.0337019140839086 210 NA FT MITOCHONDRION Mitochondrial outer membrane protein; probable minor component of the TOM (translocase of outer membrane) complex responsible for recognition and import of mitochondrially directed proteins; TOM71 has a paralog, TOM70, that arose from the whole genome duplication biological_process protein transporter activity mitochondrial outer membrane|mitochondrion|integral to membrane|integral to mitochondrial outer membrane
YMR234W YMR234W RNH1 hom Verified 1.7097030709136 0.0436603973006346 no 272 0.0413300146838382 243 NA FT CELL WALL ORG/BIOGENESIS NUCLEUS Ribonuclease H1; able to bind double-stranded RNAs and RNA-DNA hybrids; associates with RNAse polymerase I; the homolog of mammalian RNAse HII (the S. cerevisiae homolog of mammalian RNAse HI is RNH201) fungal-type cell wall organization|RNA catabolic process ribonuclease H activity intracellular|nucleus
YER175W-A_p YER175W-A YER175W-A hom Uncharacterized 1.70964520293712 0.0436657507055335 no 273 0.0389335900397887 206 NA Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YOR118W YOR118W RTC5 hom Verified 1.70752179102262 0.0438625555325618 no 274 0.0615172279084514 228 NA Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity biological_process molecular_function cytoplasm
YLR386W YLR386W VAC14 hom Verified 1.70515070558089 0.0440831604372618 no 275 0.071908115433936 334 NA FT PROTEIN LOCALIZATION|LIPID METABOLISM Protein involved in regulated synthesis of PtdIns(3,5)P(2), in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; interacts with Fig4p; activator of Fab1p phosphatidylinositol biosynthetic process|positive regulation of kinase activity protein binding, bridging fungal-type vacuole membrane|PAS complex|extrinsic to vacuolar membrane
YDL183C YDL183C YDL183C hom Verified 1.70193763317092 0.0443835300659579 no 276 0.0597400064699623 228 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene potassium ion transport|proton transport molecular_function integral to mitochondrial inner membrane
YOR173W YOR173W DCS2 hom Verified 1.7017357644183 0.0444024564161667 no 277 0.0437211068400567 221 NA Non-essential, stress induced regulatory protein; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway; mutant has increased aneuploidy tolerance deadenylation-dependent decapping of nuclear-transcribed mRNA m7G(5')pppN diphosphatase activity cytoplasmic mRNA processing body|cytoplasm
YDR482C YDR482C CWC21 hom Verified 1.69947599262793 0.0446147671233815 no 278 0.0567755403740015 234 NA FT RNA PROCESSING NUCLEUS Protein involved in RNA splicing by the spliceosome; component of a complex containing Cef1p; interacts genetically with ISY1 and BUD13; may bind RNA; has similarity to S. pombe Cwf21p mRNA splicing, via spliceosome molecular_function U2-type spliceosomal complex
YDR165W YDR165W TRM82 hom Verified 1.69787212322281 0.0447659498564907 no 279 0.0540840265825173 198 NA FT RNA PROCESSING NUCLEUS Catalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p tRNA methylation tRNA (guanine-N7-)-methyltransferase activity tRNA methyltransferase complex|nucleus
YPR089W_p YPR089W YPR089W hom Uncharacterized 1.69713554923506 0.0448355183344434 no 280 0.0488760428700617 265 NA FT GOLGI APPARATUS Protein of unknown function; exhibits genetic interaction with ERG11 and protein-protein interaction with Hsp82p biological_process molecular_function cellular_component
YLR209C YLR209C PNP1 hom Verified 1.68343101006644 0.0461458421846646 no 281 0.0525128154847447 173 NA FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM Purine nucleoside phosphorylase, specifically metabolizes inosine and guanosine nucleosides; involved in the nicotinamide riboside salvage pathway guanosine catabolic process|inosine catabolic process|NAD biosynthesis via nicotinamide riboside salvage pathway|nicotinate nucleotide salvage nicotinamide riboside hydrolase activity|inosine nucleosidase activity|purine-nucleoside phosphorylase activity intracellular
YER188W_d YER188W YER188W hom Dubious 1.68246059356976 0.046239780055024 no 282 0.061767089792679 262 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; large-scale analyses show mRNA expression increases under anaerobic conditions and two-hybrid interactions with Sst2p Unknown Unknown Unknown
YKL056C YKL056C TMA19 hom Verified 1.68126778986989 0.0463554556711107 no 283 0.0489062305555989 263 NA FT TRANSLATION|RESPONSE TO OXIDATIVE STRESS MITOCHONDRION|CYTOSKELETON Protein that associates with ribosomes; homolog of translationally controlled tumor protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and relocates to the mitochondrial outer surface upon oxidative stress cytoplasmic translation|cellular response to oxidative stress molecular_function cytosol|mitochondrion|ribosome|cytoplasm
YIL094C YIL094C LYS12 hom Verified 1.68017730448458 0.0464614118498633 no 284 0.0457254719270376 255 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate lysine biosynthetic process homoisocitrate dehydrogenase activity mitochondrion
YHR202W_p YHR202W YHR202W hom Uncharacterized 1.67249472967496 0.0472134031303686 no 285 0.0474963163507866 239 NA FT NUCLEOTIDE METABOLISM Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization biological_process molecular_function cytosol|fungal-type vacuole
YLR413W_p YLR413W YLR413W hom Uncharacterized 1.67128215223426 0.0473329800193226 no 286 0.0431912619143375 216 NA FT PLASMA MEMBRANE Putative protein of unknown function; YLR413W is not an essential gene biological_process molecular_function integral to membrane
YPL155C YPL155C KIP2 hom Verified 1.67040543912922 0.0474195871225849 no 287 0.0272603629863752 177 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION MITOCHONDRION|CYTOSKELETON Kinesin-related motor protein involved in mitotic spindle positioning, stabilizes microtubules by targeting Bik1p to the plus end; Kip2p levels are controlled during the cell cycle nuclear migration along microtubule|mitotic anaphase B|negative regulation of microtubule depolymerization microtubule motor activity mitochondrion|kinesin complex|cytoplasmic microtubule
YBR212W YBR212W NGR1 hom Verified 1.66500374408577 0.0479560044264542 no 288 0.0577434134668681 225 NA FT MITOCHONDRION ORGANIZATION RNA binding protein that negatively regulates growth rate; interacts with the 3' UTR of the mitochondrial porin (POR1) mRNA and enhances its degradation; overexpression impairs mitochondrial function; interacts with Dhh1p to mediate POR1 mRNA decay; expressed in stationary phase 3'-UTR-mediated mRNA destabilization|mitochondrion organization mRNA binding cytoplasmic mRNA processing body|cytoplasmic stress granule|perinuclear region of cytoplasm|cytoplasm
YGR104C YGR104C SRB5 hom Verified 1.66254664530131 0.0482016094227702 no 289 0.0541865808879507 274 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; required for proper termination of transcription for some genes; involved in telomere maintenance transcriptional open complex formation at RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter core RNA polymerase II binding transcription factor activity|RNA polymerase II transcription factor recruiting transcription factor activity|TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly core mediator complex
YOL033W YOL033W MSE1 hom Verified 1.66177327376916 0.0482791214577978 no 290 0.0721656318215895 295 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial glutamyl-tRNA synthetase, predicted to be palmitoylated mitochondrial glutamyl-tRNA aminoacylation|glutamyl-tRNA aminoacylation|mitochondrial translation glutamate-tRNA(Gln) ligase activity|glutamate-tRNA ligase activity mitochondrion
YKL136W_d YKL136W YKL136W hom Dubious 1.65542372816417 0.0489192880517267 no 291 0.067402508711038 253 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF APL2/YKL135C Unknown Unknown Unknown
YDR077W YDR077W SED1 hom Verified 1.65487335115178 0.0489750954622167 no 292 0.0420752574748103 227 NA FT CELL WALL ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Major stress-induced structural GPI-cell wall glycoprotein in stationary-phase cells, associates with translating ribosomes, possible role in mitochondrial genome maintenance; ORF contains two distinct variable minisatellites fungal-type cell wall organization|mitochondrial genome maintenance structural constituent of cell wall mitochondrion|ribosome|fungal-type cell wall
YGR050C_p YGR050C YGR050C hom Uncharacterized 1.65407902487745 0.0490557286308045 no 293 0.0414692034252391 216 NA Protein of unknown function; mRNA identified as translated by ribosome profiling data biological_process molecular_function cellular_component
YER185W YER185W PUG1 hom Verified 1.65292862153836 0.0491726956496966 no 294 0.0481859938346709 222 NA FT PLASMA MEMBRANE Plasma membrane protein with roles in the uptake of protoprophyrin IX and the efflux of heme; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of proteins heme transport molecular_function integral to membrane|plasma membrane
YPL108W_p YPL108W YPL108W hom Uncharacterized 1.65269699283657 0.0491962733661798 no 295 0.0583761000064366 253 NA Cytoplasmic protein of unknown function; non-essential gene that is induced in a GDH1 deleted strain with altered redox metabolism; GFP-fusion protein is induced in response to the DNA-damaging agent MMS biological_process molecular_function cytoplasm
YGR214W YGR214W RPS0A hom Verified 1.64602511451838 0.0498792942400744 no 296 0.0472676766430112 240 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION RIBOSOME Ribosomal 40S subunit protein S0A; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2; RPS0A has a paralog, RPS0B, that arose from the whole genome duplication; cytoplasmic translation|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA export from nucleus|ribosomal small subunit assembly|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit|90S preribosome
YFL012W_p YFL012W YFL012W hom Uncharacterized 1.64529263143731 0.0499547393359668 no 297 0.0664606528493791 298 NA Putative protein of unknown function; transcribed during sporulation; null mutant exhibits increased resistance to rapamycin biological_process molecular_function cellular_component
YGR070W YGR070W ROM1 hom Verified 1.64490337037977 0.0499948698895474 no 298 0.0572612537361008 282 NA FT SIGNALING|NUCLEOTIDE METABOLISM GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP small GTPase mediated signal transduction|activation of Rho GTPase activity Rho guanyl-nucleotide exchange factor activity intracellular
YPL139C YPL139C UME1 hom Verified 1.6438966634938 0.0500987747424816 no 299 0.05095576274216 279 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Negative regulator of meiosis, required for repression of a subset of meiotic genes during vegetative growth, binding of histone deacetylase Rpd3p required for activity, contains a NEE box and a WD repeat motif; homologous with Wtm1p, Wtm2p positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of transcription from RNA polymerase I promoter|negative regulation of chromatin silencing at telomere|positive regulation of transcription from RNA polymerase II promoter|regulation of meiosis transcription corepressor activity Rpd3S complex|Rpd3L-Expanded complex|nucleus|Rpd3L complex
YMR207C YMR207C HFA1 hom Verified 1.64190035453869 0.0503053281943026 no 300 0.0437596037364657 216 NA FT KETONE METABOLISM|LIPID METABOLISM MITOCHONDRION Mitochondrial acetyl-coenzyme A carboxylase; catalyzes the production of malonyl-CoA in mitochondrial fatty acid biosynthesis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress fatty acid biosynthetic process acetyl-CoA carboxylase activity mitochondrion
YLL044W_d YLL044W YLL044W hom Dubious 1.6404481865439 0.0504560066313381 no 301 0.049413848113402 246 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLL044W and the overlapping gene RPL8B is reduced in the gcr1 null mutant Unknown Unknown Unknown
YDL078C YDL078C MDH3 hom Verified 1.63938634590721 0.0505664117344986 no 302 0.0332507244883569 163 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM Peroxisomal malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle glyoxylate cycle|fatty acid beta-oxidation|malate metabolic process|NADH regeneration L-malate dehydrogenase activity|mRNA binding peroxisomal matrix|peroxisome
YBR223C YBR223C TDP1 hom Verified 1.63497217334357 0.0510274405500322 no 303 0.0571439719577143 242 NA FT RESPONSE TO DNA DAMAGE NUCLEUS Tyrosyl-DNA phosphodiesterase I; hydrolyzes 3' and 5'-phosphotyrosyl bonds; involved in the repair of DNA lesions created by topoisomerase I and topoisomerase II; mutations in human homolog result in the neurodegenerative disease SCANI DNA repair 3'-tyrosyl-DNA phosphodiesterase activity|5'-tyrosyl-DNA phosphodiesterase activity nucleus
YDR345C YDR345C HXT3 hom Verified 1.6290718227547 0.0516489076846129 no 304 0.0668779367025758 308 NA FT PLASMA MEMBRANE Low affinity glucose transporter of the major facilitator superfamily; expression is induced in low or high glucose conditions; HXT3 has a paralog, HXT5, that arose from the whole genome duplication hexose transport|transmembrane transport mannose transmembrane transporter activity|fructose transmembrane transporter activity|glucose transmembrane transporter activity integral to membrane|plasma membrane
YAR014C YAR014C BUD14 hom Verified 1.62875160417965 0.0516828067891226 no 305 0.0472079831799057 294 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH Protein involved in bud-site selection; Bud14p-Glc7p complex is a cortical regulator of dynein; inhibitor of the actin assembly factor Bnr1p (formin); diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; relative distribution to the nucleus increases upon DNA replication stress regulation of cell shape during vegetative growth phase|regulation of protein localization|regulation of transcription, DNA-dependent|cytoskeleton organization|negative regulation of actin filament polymerization protein phosphatase type 1 regulator activity incipient cellular bud site|cellular bud neck|cellular bud tip
YLR220W YLR220W CCC1 hom Verified 1.62457558287406 0.0521265116754751 no 306 0.0454765546749593 231 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Putative vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack the ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation; relative distribution to the vacuole decreases upon DNA replication stress manganese ion transport|cellular calcium ion homeostasis|cellular iron ion homeostasis|cellular manganese ion homeostasis|ferrous iron transport manganese ion transmembrane transporter activity|ferrous iron transmembrane transporter activity fungal-type vacuole membrane|integral to membrane|Golgi apparatus
YJR035W YJR035W RAD26 hom Verified 1.6218943103017 0.0524129900099315 no 307 0.0379535651321927 207 NA FT RESPONSE TO DNA DAMAGE NUCLEUS Protein involved in transcription-coupled nucleotide excision repair of UV-induced DNA lesions; recruitment to DNA lesions is dependent on an elongating RNA polymerase II; homolog of human CSB protein transcription-coupled nucleotide-excision repair|nucleotide-excision repair DNA-dependent ATPase activity nucleus|cytoplasm
YJL158C YJL158C CIS3 hom Verified 1.62104851655452 0.0525036170183961 no 308 0.0413863542488533 202 NA FT CELL WALL ORG/BIOGENESIS ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family fungal-type cell wall organization structural constituent of cell wall extracellular region|fungal-type cell wall|endoplasmic reticulum|plasma membrane|cellular bud tip
YPL188W YPL188W POS5 hom Verified 1.62053573097831 0.0525586226574426 no 309 0.0523899410854061 291 NA FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS MITOCHONDRION Mitochondrial NADH kinase, phosphorylates NADH; also phosphorylates NAD(+) with lower specificity; required for the response to oxidative stress cellular response to oxidative stress|NADP biosynthetic process NADH kinase activity mitochondrion|mitochondrial matrix
YLR280C_d YLR280C YLR280C hom Dubious 1.61254429131467 0.0534217749647097 no 310 0.0399189904814665 165 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YMR251W YMR251W GTO3 hom Verified 1.61239640600096 0.0534378532274862 no 311 0.0604872163416732 221 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Omega class glutathione transferase; putative cytosolic localization glutathione metabolic process glutathione transferase activity cytoplasm
YDR518W YDR518W EUG1 hom Verified 1.61232053938238 0.0534461030222652 no 312 0.0472171912270661 251 NA FT ENDOPLASMIC RETICULUM Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER protein folding protein disulfide isomerase activity|protein disulfide oxidoreductase activity endoplasmic reticulum
YLR225C_p YLR225C YLR225C hom Uncharacterized 1.61227822434582 0.0534507048304765 no 313 0.0582480142122105 283 NA FT RESPONSE TO OXIDATIVE STRESS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR225C is not an essential gene biological_process molecular_function cytoplasm
YDR068W YDR068W DOS2 hom Verified 1.60895735582181 0.0538128332857622 no 314 0.0341521442446705 155 NA Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm biological_process molecular_function cytoplasm
YNL068C YNL068C FKH2 hom Verified 1.60882823246085 0.0538269528545194 no 315 0.0429040637567618 240 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|MITOCHONDRION ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Forkhead family transcription factor; plays a major role in the expression of G2/M phase genes; positively regulates transcriptional elongation; negative role in chromatin silencing at HML and HMR; substrate of the Cdc28p/Clb5p kinase; FKH2 has a paralog, FKH1, that arose from the whole genome duplication negative regulation of chromatin silencing at silent mating-type cassette|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription involved in G2/M-phase of mitotic cell cycle|negative regulation of transcription involved in G1 phase of mitotic cell cycle|Unknown|chromatin remodeling|negative regulation of transcription involved in G2/M-phase of mitotic cell cycle RNA polymerase II transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II transcription factor binding transcription factor activity nucleus
YOR067C YOR067C ALG8 hom Verified 1.60817561985958 0.0538983605729689 no 316 0.0920110783704396 393 NA FF|FT LIPID METABOLISM|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Glucosyl transferase, involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p oligosaccharide-lipid intermediate biosynthetic process|protein N-linked glycosylation dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity integral to membrane|endoplasmic reticulum membrane
YJL092W YJL092W SRS2 hom Verified 1.60712492857109 0.0540134829181616 no 317 0.0556699437164921 297 NA FT RESPONSE TO DNA DAMAGE NUCLEUS DNA helicase and DNA-dependent ATPase involved in DNA repair and checkpoint recovery, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability DNA repair|double-strand break repair via nonhomologous end joining|DNA duplex unwinding DNA helicase activity nucleus
YPL022W YPL022W RAD1 hom Verified 1.60677313784698 0.0540520714582044 no 318 0.0530182553466518 252 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein mitotic recombination|meiotic mismatch repair|nucleotide-excision repair, DNA incision, 5'-to lesion|double-strand break repair via single-strand annealing, removal of nonhomologous ends|removal of nonhomologous ends single-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity nucleotide-excision repair factor 1 complex|nucleus
YDL071C_d YDL071C YDL071C hom Dubious 1.60641247168043 0.0540916562120132 no 319 0.0722545601272642 296 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF BDF2/YDL070W Unknown Unknown Unknown
YNR009W YNR009W NRM1 hom Verified 1.606139207827 0.0541216634392196 no 320 0.0453781516061115 219 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE NUCLEUS Transcriptional co-repressor of MBF (MCB binding factor)-regulated gene expression; Nrm1p associates stably with promoters via MBF to repress transcription upon exit from G1 phase negative regulation of transcription involved in G1 phase of mitotic cell cycle repressing transcription factor binding|transcription factor binding transcription factor activity MBF transcription complex|nucleus|cytoplasm
YJL122W YJL122W ALB1 hom Verified 1.605801867908 0.0541587250570315 no 321 0.0373037980410543 181 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS NUCLEUS Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p ribosomal large subunit biogenesis molecular_function ribosome|nucleus|cytoplasm
YMR142C YMR142C RPL13B hom Verified 1.60411293743911 0.0543445803304301 no 322 0.0636110542129404 301 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L13B; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13B has a paralog, RPL13A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YPL174C YPL174C NIP100 hom Verified 1.60161435976551 0.0546204567072652 no 323 0.0679851832054027 335 NA FT CELL CYCLE|CYTOSKELETON ORGANIZATION CYTOSKELETON Large subunit of the dynactin complex, which is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued) establishment of mitotic spindle orientation microtubule binding dynactin complex|cell cortex|spindle pole body|astral microtubule
YJL065C YJL065C DLS1 hom Verified 1.60127914212164 0.0546575533187255 no 324 0.0775245884659312 280 NA FT GENE SILENCING NUCLEUS Subunit of ISW2/yCHRAC chromatin accessibility complex; ISW2/yCHRAC also includes Itc1p, Isw2p, and Dpb4p; involved in inheritance of telomeric silencing; DLS1 has a paralog, DPB3, that arose from the whole genome duplication chromatin silencing at telomere molecular_function chromatin accessibility complex|nucleus
YBR108W YBR108W AIM3 hom Verified 1.59142376285884 0.0557571200011593 no 325 0.0481792711809847 233 NA FT CYTOSKELETON ORGANIZATION CYTOSKELETON Protein interacting with Rvs167p; null mutant is viable and displays elevated frequency of mitochondrial genome loss actin cortical patch assembly molecular_function membrane raft|actin cortical patch
YLR312C_p YLR312C YLR312C hom Uncharacterized 1.59000408433059 0.0559169421997256 no 326 0.0570663372323964 242 NA Putative protein of unknown function biological_process molecular_function cellular_component
YCR106W YCR106W RDS1 hom Verified 1.58931671563047 0.0559944533835133 no 327 0.0455143661243927 315 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Putative zinc cluster transcription factor; involved in conferring resistance to cycloheximide response to xenobiotic stimulus sequence-specific DNA binding|DNA binding nucleus
YKR077W YKR077W MSA2 hom Verified 1.58799102072749 0.0561441847918514 no 328 0.0531813205780303 261 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE NUCLEUS Putative transcriptional activator, that interacts with G1-specific transcription factor, MBF and G1-specific promoters; ortholog of Msa2p, an MBF and SBF activator that regulates G1-specific transcription and cell cycle initiation regulation of transcription involved in G1 phase of mitotic cell cycle molecular_function nucleus|cytoplasm
YPR118W YPR118W MRI1 hom Verified 1.58518594734928 0.0564620461899703 no 329 0.0655837042664283 218 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS 5'-methylthioribose-1-phosphate isomerase; catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway L-methionine salvage from methylthioadenosine S-methyl-5-thioribose-1-phosphate isomerase activity nucleus|cytoplasm
YDL159W-A_p YDL159W-A YDL159W-A hom Uncharacterized 1.58463177493365 0.0565250105778591 no 330 0.0462063803914615 285 NA Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species biological_process molecular_function cellular_component
YEL051W YEL051W VMA8 hom Verified 1.57563552770057 0.0575549117544598 no 331 0.0743104142694475 285 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Subunit D of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis vacuolar acidification proton-transporting ATPase activity, rotational mechanism fungal-type vacuole membrane|vacuolar proton-transporting V-type ATPase, V1 domain|integral to membrane
YIL079C YIL079C AIR1 hom Verified 1.57506869431046 0.0576202945896891 no 332 0.0620179062731848 268 NA FT RNA PROCESSING NUCLEUS Zinc knuckle protein; involved in nuclear RNA processing and degradation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; AIR1 has a paralog, AIR2, that arose from the whole genome duplication nuclear mRNA surveillance of mRNA 3'-end processing|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|ncRNA polyadenylation|nuclear polyadenylation-dependent snRNA catabolic process polynucleotide adenylyltransferase activity nucleolus|TRAMP complex
YDR481C YDR481C PHO8 hom Verified 1.57178313451983 0.058000427099119 no 333 0.0638318870804864 259 NA FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM Repressible vacuolar alkaline phosphatase; regulated by levels of Pi and by Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides; contributes to NAD+ metabolism by producing nicotinamide riboside from NMN nicotinamide nucleotide metabolic process|protein dephosphorylation nucleotide phosphatase activity|alkaline phosphatase activity fungal-type vacuole membrane
YKL160W YKL160W ELF1 hom Verified 1.5707041686086 0.0581256902339757 no 334 0.0538353185815649 270 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS Transcription elongation factor that contains a conserved zinc finger domain; implicated in the maintenance of proper chromatin structure in actively transcribed regions; deletion inhibits Brome mosaic virus (BMV) gene expression regulation of transcription by chromatin organization|transcription elongation from RNA polymerase II promoter RNA polymerase II core binding transcription elongation factor complex|nucleus
YFR043C YFR043C IRC6 hom Verified 1.56450983539244 0.0588489425138458 no 335 0.0613966218819383 292 NA Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci biological_process molecular_function cellular_component
YNL198C_d YNL198C YNL198C hom Dubious 1.56030353893433 0.0593440837460682 no 336 0.0522124578352991 243 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YCR003W YCR003W MRPL32 hom Verified 1.55648049759741 0.0597969383185153 no 337 0.0912902919911601 379 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit
YER173W YER173W RAD24 hom Verified 1.55594912820038 0.0598600948741482 no 338 0.065950285854978 239 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein reciprocal meiotic recombination|DNA damage checkpoint|nucleotide-excision repair DNA clamp loader activity Rad17 RFC-like complex|nucleus
YER130C_p YER130C YER130C hom Uncharacterized 1.55537483069679 0.0599284124420452 no 339 0.103048951164675 402 NA FT NUCLEUS Protein of unknown function; transcription is regulated by Haa1p, Sok2p and Zap1p transcriptional activators; computational analysis suggests a role as a transcription factor; C. albicans homolog (MNL1) plays a role in adaptation to stress biological_process sequence-specific DNA binding cellular_component
YMR175W YMR175W SIP18 hom Verified 1.55288005990243 0.0602258956899062 no 340 0.043897423706097 194 NA Phospholipid-binding hydrophilin; essential to overcome desiccation-rehydration process; expression is induced by osmotic stress cellular response to water deprivation phospholipid binding cytoplasm
YKL033W-A_p YKL033W-A YKL033W-A hom Uncharacterized 1.55168904639557 0.0603683224343143 no 341 0.0873130295642419 365 NA Putative protein of unknown function; similar to uncharacterized proteins from other fungi biological_process molecular_function cellular_component
YBR105C YBR105C VID24 hom Verified 1.55115659963575 0.0604320800096996 no 342 0.0698865195535775 296 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|KETONE METABOLISM|MEMBRANE ORGANIZATION|CARBOHYDRATE METABOLISM|PROTEOLYSIS|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM GID Complex regulatory subunit; binds GID Complex in response to glucose through interactions with complex member Vid28p; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; promotes proteasome-dependent catabolite degradation of FBPase; peripheral membrane protein located at Vid (vacuole import and degradation) vesicles negative regulation of gluconeogenesis|vesicle fusion with vacuole|vacuolar protein catabolic process|proteasomal ubiquitin-dependent protein catabolic process|vesicle-mediated transport|protein targeting to vacuole molecular_function cytoplasmic membrane-bounded vesicle|GID complex|extrinsic to membrane
YJL162C YJL162C JJJ2 hom Verified 1.55058213487878 0.0605009280897502 no 343 0.0517941063527834 229 NA FT NUCLEUS Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein biological_process molecular_function nucleus|cytoplasm
YML090W_d YML090W YML090W hom Dubious 1.55011618802899 0.0605568156483249 no 344 0.0564104643862378 234 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source Unknown Unknown Unknown
YOR190W YOR190W SPR1 hom Verified 1.54962828650069 0.0606153798199576 no 345 0.0621865999750711 272 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance ascospore formation glucan exo-1,3-beta-glucosidase activity fungal-type cell wall|ascospore wall
YMR159C YMR159C ATG16 hom Verified 1.54829469984283 0.060775679977691 no 346 0.0594905227237609 271 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Conserved protein involved in autophagy; interacts with Atg12p-Atg5p conjugates to form Atg12p-Atg5p-Atg16p multimers, which localize to the pre-autophagosomal structure and are required for autophagy; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress C-terminal protein lipidation|piecemeal microautophagy of nucleus|mitochondrion degradation|macroautophagy|CVT pathway protein binding, bridging|Atg8 ligase activity Atg12-Atg5-Atg16 complex|pre-autophagosomal structure
YML062C YML062C MFT1 hom Verified 1.54743147242674 0.0608796185026131 no 347 0.0723426543243654 343 NA FT TRANSCRIPTION FROM RNA POL II|RNA LOCALIZATION NUCLEUS Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance mRNA export from nucleus|DNA recombination|transcription elongation from RNA polymerase II promoter protein complex scaffold|nucleic acid binding THO complex part of transcription export complex|nucleoplasmic THO complex
YFR032C-A YFR032C-A RPL29 hom Verified 1.54684118728616 0.0609507728756396 no 348 0.0619201131783907 288 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L29; not essential for translation, but required for proper joining of large and small ribosomal subunits and for normal translation rate; homologous to mammalian ribosomal protein L29, no bacterial homolog cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit|cytoplasm
YER015W YER015W FAA2 hom Verified 1.54601928864882 0.061049954756077 no 349 0.061849219544862 314 NA FT KETONE METABOLISM|LIPID METABOLISM MITOCHONDRION Medium chain fatty acyl-CoA synthetase, activates imported fatty acids; accepts a wide range of fatty acid chain lengths with a preference for medium chains, C9:0-C13:0; localized to the peroxisome long-chain fatty acid metabolic process long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity|medium-chain fatty acid-CoA ligase activity mitochondrion|peroxisome
YCR105W YCR105W ADH7 hom Verified 1.53957058363912 0.0618325302274424 no 350 0.0815231247625666 272 NA FT OXIDATION-REDUCTION PROCESS NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance alcohol metabolic process alcohol dehydrogenase (NADP+) activity cellular_component
YLR329W YLR329W REC102 hom Verified 1.53956033676506 0.0618337799271057 no 351 0.0738849241325425 251 NA FT CELL CYCLE NUCLEUS|CHROMOSOME Protein involved in early stages of meiotic recombination; required for chromosome synapsis; forms a complex with Rec104p and Spo11p necessary during the initiation of recombination meiotic DNA double-strand break formation|reciprocal meiotic recombination molecular_function condensed nuclear chromosome|nucleus
YPL100W YPL100W ATG21 hom Verified 1.53710270113376 0.0621340808117489 no 352 0.0659620807846113 297 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Phosphoinositide binding protein required for vesicle formation in the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein piecemeal microautophagy of nucleus|vesicle organization|mitochondrion degradation|macroautophagy|protein localization to pre-autophagosomal structure|CVT pathway|protein lipidation phosphatidylinositol binding endosome|cytosol|fungal-type vacuole membrane
YMR021C YMR021C MAC1 hom Verified 1.53277432365201 0.0626657345673767 no 353 0.173232735082707 671 NA FF|FT TRANSCRIPTION FROM RNA POL II|ION HOMEOSTASIS|ION HOMEOSTASIS NUCLEUS Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport cellular copper ion homeostasis|positive regulation of protein catabolic process|positive regulation of transcription from RNA polymerase II promoter core promoter proximal region DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YIR032C YIR032C DAL3 hom Verified 1.53210194407858 0.0627486400501873 no 354 0.0645329107512772 288 NA FT PLASMA MEMBRANE Ureidoglycolate hydrolase, converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation; expression sensitive to nitrogen catabolite repression allantoin catabolic process ureidoglycolate hydrolase activity membrane
YNL097C-B_p YNL097C-B YNL097C-B hom Uncharacterized 1.5303376215912 0.0629665902652334 no 355 0.0463988501263204 196 NA Putative protein of unknown function biological_process molecular_function cellular_component
YFR057W_p YFR057W YFR057W hom Uncharacterized 1.52931866364222 0.0630927325125637 no 356 0.0728448484905308 258 NA Putative protein of unknown function biological_process molecular_function cellular_component
YMR289W YMR289W ABZ2 hom Verified 1.52734101127999 0.0633381182431509 no 357 0.0717005870410672 338 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis folic acid biosynthetic process 4-amino-4-deoxychorismate lyase activity cytoplasm
YLR183C YLR183C TOS4 hom Verified 1.52618432315144 0.0634819832718067 no 358 0.0679959151165684 275 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION|CHROMOSOME Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; expression is periodic and peaks in G1; relative distribution to the nucleus increases upon DNA replication stress; TOS4 has a paralog, PLM2, that arose from the whole genome duplication response to DNA damage stimulus chromatin binding nuclear chromatin|Rpd3L-Expanded complex|mitochondrion|nucleus|cytoplasm
YBR288C YBR288C APM3 hom Verified 1.52617316520697 0.0634833722973314 no 359 0.0834826131402933 374 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway Golgi to vacuole transport|vesicle-mediated transport molecular_function AP-3 adaptor complex
YDL133C-A YDL133C-A RPL41B hom Verified 1.52591079328117 0.0635160411619062 no 360 0.0509318494502811 237 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YDL231C YDL231C BRE4 hom Verified 1.52444618632905 0.0636986450143819 no 361 0.0648880815829201 265 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION Zinc finger protein containing five transmembrane domains; null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect intracellular transport endocytosis molecular_function integral to membrane
YBL024W YBL024W NCL1 hom Verified 1.52430384671171 0.0637164133459243 no 362 0.0957254526268076 329 NA FT RNA PROCESSING NUCLEUS S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase, methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; increases proportion of tRNALeu(CAA) with m5C at wobble position in response to hydrogen peroxide, causing selective translation of mRNA from genes enriched in TTG codon; loss of NCL1 confers hypersensitivity to oxidative stress; similar to Nop2p and human proliferation associated nucleolar protein p120 tRNA methylation tRNA (cytosine-5-)-methyltransferase activity nucleus
YCR034W YCR034W FEN1 hom Verified 1.52391406320896 0.0637650899685054 no 363 0.117613190616229 506 NA FF|FT VESICLE-MEDIATED TRANSPORT|KETONE METABOLISM|LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway; FEN1 has a paralog, ELO1, that arose from the whole genome duplication fatty acid elongation|vesicle-mediated transport|sphingolipid biosynthetic process fatty acid elongase activity integral to membrane|endoplasmic reticulum|endoplasmic reticulum membrane
YKL197C YKL197C PEX1 hom Verified 1.52243373965761 0.0639502180983245 no 364 0.0601480585658533 263 NA FT PROTEIN LOCALIZATION|SIGNALING|PEROXISOME ORGANIZATION AAA-peroxin that heterodimerizes with AAA-peroxin Pex6p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; induced by oleic acid and upregulated during anaerobiosis protein import into peroxisome matrix, receptor recycling ATPase activity|protein heterodimerization activity peroxisomal membrane|peroxisome
YJR107W_p YJR107W YJR107W hom Uncharacterized 1.52112641785994 0.0641140580670033 no 365 0.0580584767237851 228 NA FT LIPID METABOLISM Putative lipase biological_process lipase activity cellular_component
YKR018C YKR018C YKR018C hom Verified 1.51736686572759 0.0645870423565388 no 366 0.0595112792202817 257 NA FT NUCLEUS|MITOCHONDRION Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress; YKR018C has a paralog, IML2, that arose from the whole genome duplication biological_process molecular_function nucleus|cytoplasm
YGR226C_d YGR226C YGR226C hom Dubious 1.51726018851642 0.064600502713642 no 367 0.0681290386422134 248 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; overlaps significantly with a verified ORF, AMA1/YGR225W Unknown Unknown Unknown
YDR035W YDR035W ARO3 hom Verified 1.51547414913079 0.0648261860291496 no 368 0.150586714155611 617 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS|MITOCHONDRION 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan aromatic amino acid family biosynthetic process 3-deoxy-7-phosphoheptulonate synthase activity mitochondrion|nucleus|cytoplasm
YOR263C_d YOR263C YOR263C hom Dubious 1.51212499028492 0.0652510342612989 no 369 0.0676921979747786 269 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF DES3/YOR264W Unknown Unknown Unknown
YML012C-A_d YML012C-A YML012C-A hom Dubious 1.50905054401298 0.0656429333423639 no 370 0.0776379125983543 382 NA FF Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SEL1 Unknown Unknown Unknown
YLR113W YLR113W HOG1 hom Verified 1.50661046486738 0.065955266715861 no 371 0.0863854087689007 265 NA FT TRANSCRIPTION FROM RNA POL II|SIGNALING|PROTEIN PHOSPHORYLATION NUCLEUS Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNA Pol II in response to osmotic shock; acts via three independent osmosensors; mitophagy-specific regulator; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p; protein abundance increases in response to DNA replication stress negative regulation of transcription from RNA polymerase II promoter by pheromones|protein phosphorylation|hyperosmotic response|response to arsenic-containing substance|osmosensory signaling pathway|positive regulation of transcription from RNA polymerase II promoter|cellular response to heat MAP kinase activity nucleus|cytoplasm
YMR084W_p YMR084W YMR084W hom Uncharacterized 1.50558898005737 0.0660863595695373 no 372 0.0706647311592878 331 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Putative protein of unknown function; YMR084W and adjacent ORF YMR085W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1 biological_process molecular_function cellular_component
YMR019W YMR019W STB4 hom Verified 1.50530177367395 0.0661232547024551 no 373 0.0536900342075582 195 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Putative transcription factor; contains a Zn(II)2Cys6 zinc finger domain characteristic of DNA-binding proteins; computational analysis suggests a role in regulation of expression of genes encoding transporters; binds Sin3p in a two-hybrid assay; biological_process sequence-specific DNA binding|DNA binding nucleus
YCL001W-B_p YCL001W-B YCL001W-B hom Uncharacterized 1.5023231424174 0.0665068373640237 no 374 0.0746764680272965 253 NA Putative protein of unknown function; present in a region duplicated between chromosomes XIV and III; YCL001W-B has a paralog, DOM34, that arose from the whole genome duplication biological_process molecular_function cellular_component
YBR177C YBR177C EHT1 hom Verified 1.50099873232008 0.0666779447252333 no 375 0.0606151385157154 258 NA FT KETONE METABOLISM|LIPID METABOLISM MITOCHONDRION Acyl-coenzymeA:ethanol O-acyltransferase; plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane; EHT1 has a paralog, EEB1, that arose from the whole genome duplication medium-chain fatty acid catabolic process|medium-chain fatty acid biosynthetic process|cellular lipid metabolic process short-chain carboxylesterase activity|alcohol O-butanoyltransferase activity|serine hydrolase activity mitochondrial outer membrane|mitochondrion|lipid particle
YCR020C-A YCR020C-A MAK31 hom Verified 1.50082540434132 0.0667003630474495 no 376 0.0568470208972127 277 NA Non-catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus; member of the Sm protein family N-terminal protein amino acid acetylation peptide alpha-N-acetyltransferase activity NatC complex
YFR053C YFR053C HXK1 hom Verified 1.49890437560421 0.066949220545826 no 377 0.080111390769666 332 NA FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Hexokinase isoenzyme 1; a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves hexokinase Hxk2p; HXK1 has a paralog, HXK2, that arose from the whole genome duplication mannose metabolic process|glucose import|glycolysis|fructose import|glucose metabolic process|fructose metabolic process hexokinase activity cytosol|mitochondrion|cytoplasm
YMR012W YMR012W CLU1 hom Verified 1.49560748091634 0.0673779862701399 no 378 0.0590220515418952 251 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION eIF3 component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation, can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant translational initiation|mitochondrion organization molecular_function eukaryotic translation initiation factor 3 complex|cytoplasm
YLR287C-A YLR287C-A RPS30A hom Verified 1.49261764755257 0.0677686505930822 no 379 0.0719971883288947 323 NA FT TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S30, no bacterial homolog; RPS30A has a paralog, RPS30B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic small ribosomal subunit|cytoplasmic stress granule
YDR024W_d YDR024W FYV1 hom Dubious 1.49055865017145 0.0680387036685137 no 380 0.0826889880413634 343 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; mutation decreases survival upon exposure to K1 killer toxin Unknown Unknown Unknown
YJL037W YJL037W IRC18 hom Verified 1.48675811128929 0.0685393542713132 no 381 0.0722348767505984 367 NA Putative protein of unknown function; expression induced in respiratory-deficient cells and in carbon-limited chemostat cultures; similar to adjacent ORF, YJL038C; null mutant displays increased levels of spontaneous Rad52p foci biological_process molecular_function cellular_component
YDR100W YDR100W TVP15 hom Verified 1.48034492972006 0.0693906092782005 no 382 0.0674652873734671 221 NA FT VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p vesicle-mediated transport molecular_function COPI-coated vesicle|integral to membrane|integral to Golgi membrane
YER176W YER176W ECM32 hom Verified 1.47927116738588 0.0695339277964921 no 383 0.0591814900146391 262 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes regulation of translational termination RNA helicase activity|DNA helicase activity polysome
YCR037C YCR037C PHO87 hom Verified 1.47718501890174 0.0698130242262076 no 384 0.0706382189925517 310 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Low-affinity inorganic phosphate (Pi) transporter; involved in activation of PHO pathway; expression is independent of Pi concentration and Pho4p activity; contains 12 membrane-spanning segments; PHO87 has a paralog, PHO90, that arose from the whole genome duplication phosphate ion transport|transmembrane transport inorganic phosphate transmembrane transporter activity integral to membrane|membrane
YML102W YML102W CAC2 hom Verified 1.4771295277233 0.0698204598964514 no 385 0.0719847170023248 268 NA FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription DNA replication-dependent nucleosome assembly histone binding chromosome, centromeric region|CAF-1 complex
YLR262C-A YLR262C-A TMA7 hom Verified 1.47693956802285 0.0698459186055207 no 386 0.064044823769973 320 NA FT TRANSLATION NUCLEUS Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin; protein abundance increases in response to DNA replication stress cytoplasmic translation molecular_function nucleus|cytoplasm
YIR005W YIR005W IST3 hom Verified 1.47353228981277 0.0703037818677866 no 387 0.0614193249209143 291 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RNA LOCALIZATION NUCLEUS Component of the U2 snRNP, required for the first catalytic step of splicing and for spliceosomal assembly; interacts with Rds3p and is required for Mer1p-activated splicing mRNA export from nucleus|spliceosomal complex assembly|mRNA splicing, via spliceosome|generation of catalytic spliceosome for first transesterification step first spliceosomal transesterification activity RES complex|U2 snRNP
YPR001W YPR001W CIT3 hom Verified 1.46657570906711 0.0712457559755706 no 388 0.0863716316978876 348 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate propionate catabolic process, 2-methylcitrate cycle|propionate metabolic process|tricarboxylic acid cycle 2-methylcitrate synthase activity|citrate (Si)-synthase activity mitochondrion
YDR147W YDR147W EKI1 hom Verified 1.46644203675601 0.0712639506456038 no 389 0.0648554532745551 262 NA FT LIPID METABOLISM Ethanolamine kinase; primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; exhibits some choline kinase activity, thus contributing to phosphatidylcholine synthesis via the CDP-choline pathway; EKI1 has a paralog, CKI1, that arose from the whole genome duplication phosphatidylethanolamine biosynthetic process|phosphatidylcholine biosynthetic process ethanolamine kinase activity|choline kinase activity cytoplasm
YML094C-A_d YML094C-A YML094C-A hom Dubious 1.46414816127123 0.0715767352761122 no 390 0.0811348011070563 380 NA FF Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene GIM5/YML094W; deletion confers sensitivity to GSAO Unknown Unknown Unknown
YOR155C YOR155C ISN1 hom Verified 1.46389634709822 0.0716111358172925 no 391 0.067735860477675 224 NA FT NUCLEOTIDE METABOLISM Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms nicotinamide riboside biosynthetic process|inosine salvage|nicotinic acid riboside biosynthetic process IMP 5'-nucleotidase activity cellular_component
YLR319C YLR319C BUD6 hom Verified 1.46375292683651 0.0716307342460405 no 392 0.0815734348046005 245 NA FT CELL CYCLE|CHROMATIN ORGANIZATION|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Actin- and formin-interacting protein; stimulates actin cable nucleation by recruiting actin monomers to Bni1p; involved in polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate bipolar cellular bud site selection|positive regulation of formin-nucleated actin cable assembly|cellular bud site selection|Rho protein signal transduction|extrachromosomal circular DNA localization involved in cell aging|establishment of cell polarity|response to osmotic stress|cytokinesis cytoskeletal regulatory protein binding polarisome|actin cap|spindle pole body|mating projection tip
YLR083C YLR083C EMP70 hom Verified 1.46355381506674 0.0716579497605679 no 393 0.0956223982789705 301 NA FT VESICLE-MEDIATED TRANSPORT|ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT Protein with a role in cellular adhesion, filamentous growth, and endosome-to-vacuole sorting; similar to Tmn2p and Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments cellular copper ion homeostasis|vacuolar transport|pseudohyphal growth|endosomal transport|invasive growth in response to glucose limitation molecular_function endosome|fungal-type vacuole membrane|integral to membrane
YNL010W_p YNL010W YNL010W hom Uncharacterized 1.46227636156184 0.0718327467416795 no 394 0.0811581696941647 333 NA FT NUCLEUS Putative protein of unknown function with similarity to phosphoserine phosphatases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; homozygous diploid mutant shows an increase in glycogen accumulation biological_process molecular_function nucleus|cytoplasm
YMR027W_p YMR027W YMR027W hom Uncharacterized 1.46203154042244 0.0718662835060881 no 395 0.0850550231872397 348 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR027W is not an essential gene biological_process molecular_function nucleus|cytoplasm
YBR013C_p YBR013C YBR013C hom Uncharacterized 1.45948650693746 0.0722156258593284 no 396 0.0795168772480674 404 NA Putative protein of unknown function, haploid deletion mutant exhibits synthetic phenotype with alpha-synuclein biological_process molecular_function cellular_component
YER114C YER114C BOI2 hom Verified 1.45806878564364 0.0724107920761793 no 397 0.0960885480530633 376 NA FT SIGNALING|CELL DIVISION SITE OF POLARIZED GROWTH|CYTOSKELETON Protein implicated in polar growth, functionally redundant with Boi1p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; BOI2 has a paralog, BOI1, that arose from the whole genome duplication cytokinesis, completion of separation|establishment of cell polarity|budding cell apical bud growth|Rho protein signal transduction phospholipid binding site of polarized growth|cellular bud|cellular bud neck
YMR056C YMR056C AAC1 hom Verified 1.45315684974585 0.0730901048589797 no 398 0.0646046215646907 322 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator; relocalizes from mitochondrion to cytoplasm upon DNA replication stress heme biosynthetic process|mitochondrial transport|heme transport|aerobic respiration ATP:ADP antiporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YJR074W YJR074W MOG1 hom Verified 1.45284297444399 0.0731336785206754 no 399 0.0780465846134404 366 NA FT PROTEIN LOCALIZATION|RNA LOCALIZATION NUCLEUS Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p protein import into nucleus Ran GTPase binding nucleus
YLR184W_d YLR184W YLR184W hom Dubious 1.4503992132847 0.0734736131839866 no 400 0.0687375177455831 339 NA Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOR231W YOR231W MKK1 hom Verified 1.44804213763845 0.0738026331497426 no 401 0.0707348984938315 306 NA FT SIGNALING|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION SITE OF POLARIZED GROWTH MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication signal transduction|peroxisome degradation|protein phosphorylation protein kinase activity|MAP kinase kinase activity cellular bud tip
YHR039C YHR039C MSC7 hom Verified 1.44435923539789 0.0743189756179909 no 402 0.0931136602118924 358 NA FT CELL CYCLE|OXIDATION-REDUCTION PROCESS ENDOPLASMIC RETICULUM Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids reciprocal meiotic recombination molecular_function integral to membrane|endoplasmic reticulum
YGL027C YGL027C CWH41 hom Verified 1.4438272978655 0.0743937806279156 no 403 0.0956595756228717 351 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Processing alpha glucosidase I, ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress fungal-type cell wall biogenesis|protein N-linked glycosylation mannosyl-oligosaccharide glucosidase activity endoplasmic reticulum membrane
YDR048C_d YDR048C YDR048C hom Dubious 1.44271750044195 0.0745500336593563 no 404 0.0729522875120154 258 NA Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOR219C YOR219C STE13 hom Verified 1.44239931070858 0.0745948791008881 no 405 0.0786191309088317 311 NA FT PROTEOLYSIS GOLGI APPARATUS Dipeptidyl aminopeptidase, Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences, required for maturation of alpha factor, transcription is induced by a-factor peptide pheromone maturation aminopeptidase activity trans-Golgi network
YOR126C YOR126C IAH1 hom Verified 1.44085081642648 0.074813416785534 no 406 0.048330792892 225 NA FT KETONE METABOLISM|LIPID METABOLISM Isoamyl acetate-hydrolyzing esterase, required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate, which is particularly important in sake brewing acetate metabolic process hydrolase activity, acting on ester bonds cellular_component
YMR018W_p YMR018W YMR018W hom Uncharacterized 1.43926514530094 0.0750377070653425 no 407 0.0898979533137921 326 NA FT PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION Putative protein of unknown function with similarity to human PEX5Rp (peroxin protein 5 related protein); transcription increases during colony development similar to genes involved in peroxisome biogenesis; YMR018W is not an essential gene biological_process molecular_function cellular_component
YDR369C YDR369C XRS2 hom Verified 1.4392094243115 0.0750455980142282 no 408 0.0871863787584134 423 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling double-strand break repair via nonhomologous end joining|meiotic DNA double-strand break formation|base-excision repair|telomere maintenance|sporulation resulting in formation of a cellular spore|double-strand break repair via break-induced replication single-stranded telomeric DNA binding|protein binding, bridging|DNA binding|double-stranded telomeric DNA binding|telomeric DNA binding|G-quadruplex DNA binding nucleus|Mre11 complex
YJL214W YJL214W HXT8 hom Verified 1.43803191322132 0.0752124997212698 no 409 0.0740991740944141 294 NA FT PLASMA MEMBRANE Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose hexose transport mannose transmembrane transporter activity|glucose transmembrane transporter activity|fructose transmembrane transporter activity integral to membrane|plasma membrane
YPR098C YPR098C YPR098C hom Verified 1.42778927974426 0.0766762596866938 no 410 0.0953217188450429 388 NA FT MITOCHONDRION Protein of unknown function, localized to the mitochondrial outer membrane biological_process molecular_function mitochondrial outer membrane|mitochondrion
YDR151C YDR151C CTH1 hom Verified 1.42735057597539 0.0767394346406709 no 411 0.0812719361123667 330 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS NUCLEUS Member of the CCCH zinc finger family; has similarity to mammalian Tis11 protein, which activates transcription and also has a role in mRNA degradation; may function with Tis11p in iron homeostasis nuclear-transcribed mRNA catabolic process|cellular iron ion homeostasis mRNA binding nucleus
YAL037W_p YAL037W YAL037W hom Uncharacterized 1.42265169854363 0.0774185745845359 no 412 0.0853715980922928 331 NA Putative protein of unknown function; YAL037W has a paralog, YOR342C, that arose from the whole genome duplication biological_process molecular_function cellular_component
YGR056W YGR056W RSC1 hom Verified 1.42222715201006 0.0774801594490651 no 413 0.14531239330502 523 NA FF|FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS RSC COMPLEX Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook double-strand break repair|ATP-dependent chromatin remodeling|regulation of sporulation resulting in formation of a cellular spore|double-strand break repair via nonhomologous end joining|nucleosome disassembly|transcription elongation from RNA polymerase II promoter DNA-dependent ATPase activity RSC complex
YDR136C_d YDR136C VPS61 hom Dubious 1.42154333306454 0.0775794326692057 no 414 0.188140688510187 615 NA FF Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 4% of ORF overlaps the verified gene RGP1; deletion causes a vacuolar protein sorting defect Unknown Unknown Unknown
YDR114C_p YDR114C YDR114C hom Uncharacterized 1.42153768011014 0.0775802537375495 no 415 0.0937536627438965 382 NA Putative protein of unknown function; deletion mutant exhibits poor growth at elevated pH and calcium biological_process molecular_function cellular_component
YBR141C_p YBR141C YBR141C hom Uncharacterized 1.4202091606291 0.0777733987627044 no 416 0.0681765094357127 287 NA FT NUCLEUS Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YBR141C is not an essential gene biological_process S-adenosylmethionine-dependent methyltransferase activity nucleolus
YKL128C YKL128C PMU1 hom Verified 1.41766945169006 0.078143646419486 no 417 0.0494897350732187 223 NA FT NUCLEUS Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant biological_process molecular_function nucleus|cytoplasm
YCR087C-A_p YCR087C-A YCR087C-A hom Uncharacterized 1.4151185425503 0.0785168711982127 no 418 0.0890256150029136 390 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YCR087C-A is not an essential gene biological_process molecular_function nucleolus
YOL124C YOL124C TRM11 hom Verified 1.41333850411174 0.0787781088871467 no 419 0.0754762483773572 356 NA FT RNA PROCESSING Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain tRNA methylation S-adenosylmethionine-dependent methyltransferase activity|RNA binding|tRNA (guanine-N2-)-methyltransferase activity cytoplasm|tRNA (m2G10) methyltransferase complex
YFR034C YFR034C PHO4 hom Verified 1.41245550721056 0.0789079412648314 no 420 0.112368568786032 466 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS NUCLEUS Basic helix-loop-helix (bHLH) transcription factor of the myc-family; activates transcription cooperatively with Pho2p in response to phosphate limitation; binding to 'CACGTG' motif is regulated by chromatin restriction, competitive binding of Cbf1p to the same DNA binding motif and cooperation with Pho2p,; function is regulated by phosphorylation at multiple sites and by phosphate availability cellular response to phosphate starvation|positive regulation of phosphate metabolic process|phosphate-containing compound metabolic process|chromatin remodeling|positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nucleus|cytoplasm
YOR162C YOR162C YRR1 hom Verified 1.41218659086234 0.0789475138448671 no 421 0.125957021716636 498 NA FF|FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO OXIDATIVE STRESS NUCLEUS Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication regulation of transcription from RNA polymerase II promoter in response to oxidative stress|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity nucleus
YPR145W YPR145W ASN1 hom Verified 1.41137175495672 0.0790675133990837 no 422 0.0901982473174509 371 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN1 has a paralog, ASN2, that arose from the whole genome duplication asparagine biosynthetic process asparagine synthase (glutamine-hydrolyzing) activity cytoplasm
YGR231C YGR231C PHB2 hom Verified 1.40672717167711 0.0797541526805499 no 423 0.0948364790614549 334 NA FT PROTEOLYSIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation mitochondrion inheritance|protein folding|negative regulation of proteolysis|replicative cell aging molecular_function mitochondrion|mitochondrial inner membrane
YFR044C YFR044C DUG1 hom Verified 1.40657529226346 0.0797766819313013 no 424 0.084368937303084 351 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|PROTEOLYSIS MITOCHONDRION Cys-Gly metallo-di-peptidase; forms a complex with Dug2p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p) glutathione catabolic process metallodipeptidase activity|omega peptidase activity mitochondrion|ribosome|cytoplasm
YLR387C YLR387C REH1 hom Verified 1.40555671280378 0.0799278987899139 no 425 0.103212251296711 347 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS RIBOSOME Cytoplasmic 60S subunit biogenesis factor, associates with pre-60S particles; similar to Rei1p and shares partially redundant function in cytoplasmic 60S subunit maturation; contains dispersed C2H2 zinc finger domains ribosomal large subunit biogenesis|budding cell bud growth molecular_function cytosolic large ribosomal subunit|preribosome, large subunit precursor|cytoplasm
YNL072W YNL072W RNH201 hom Verified 1.4046537812535 0.0800621278669183 no 426 0.171160470379624 599 NA FT NUCLEUS Ribonuclease H2 catalytic subunit, removes RNA primers during Okazaki fragment synthesis and errant ribonucleotides misincorporated during DNA replication; homolog of RNAse HI; related to human AGS4 which causes Aicardi-Goutieres syndrome DNA replication, removal of RNA primer ribonuclease H activity ribonuclease H2 complex|nucleus
YDR297W YDR297W SUR2 hom Verified 1.4020817428992 0.0804454191359426 no 427 0.0931083344100676 351 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis sphingolipid metabolic process sphingosine hydroxylase activity integral to membrane|endoplasmic reticulum membrane
YOL003C YOL003C PFA4 hom Verified 1.40149755907383 0.0805326684823901 no 428 0.0821598717221735 310 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases protein palmitoylation palmitoyltransferase activity integral to membrane|endoplasmic reticulum
YCR009C YCR009C RVS161 hom Verified 1.40019255241523 0.0807278327344184 no 429 0.0938914243175085 433 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION|RESPONSE TO NUTRIENT LEVELS SITE OF POLARIZED GROWTH|CYTOSKELETON Amphiphysin-like lipid raft protein; interacts with Rvs167p and regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress conjugation with cellular fusion|actin cytoskeleton reorganization|endocytosis|actin cortical patch localization|response to starvation|response to osmotic stress|lipid tube assembly|actin cytoskeleton organization cytoskeletal protein binding|lipid binding membrane raft|mating projection tip|mating projection|actin cortical patch
YPL095C YPL095C EEB1 hom Verified 1.40013481595934 0.0807364754867369 no 430 0.0954783450636366 382 NA FT KETONE METABOLISM|LIPID METABOLISM Acyl-coenzymeA:ethanol O-acyltransferase; responsible for the major part of medium-chain fatty acid ethyl ester biosynthesis during fermentation; possesses short-chain esterase activity; may be involved in lipid metabolism and detoxification; EEB1 has a paralog, EHT1, that arose from the whole genome duplication medium-chain fatty acid catabolic process|medium-chain fatty acid biosynthetic process short-chain carboxylesterase activity|alcohol O-octanoyltransferase activity cellular_component
YER161C YER161C SPT2 hom Verified 1.39844998443338 0.0809889910346412 no 431 0.104443569870734 414 NA FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|CHROMATIN ORGANIZATION NUCLEUS Protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components, has similarity to mammalian HMG1 proteins negative regulation of transcription from RNA polymerase II promoter|chromatin organization|RNA polyadenylation|transcription elongation from RNA polymerase II promoter DNA binding|DNA secondary structure binding nucleus
YJL180C YJL180C ATP12 hom Verified 1.39834174561358 0.0810052337748061 no 432 0.086782420407071 369 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Conserved protein required for assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase; mutation of human ATP12 reduces active ATP synthase levels and is associated with the disorder ATPAF2 deficiency mitochondrial proton-transporting ATP synthase complex assembly protein domain specific binding mitochondrion
YHR031C YHR031C RRM3 hom Verified 1.39709275705393 0.0811928397941126 no 433 0.0997043355864916 384 NA FT RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION NUCLEUS|CHROMOSOME DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p mitochondrial genome maintenance|replication fork progression beyond termination site|DNA replication ATP-dependent DNA helicase activity|DNA helicase activity nuclear telomeric heterochromatin|replication fork
YDR523C YDR523C SPS1 hom Verified 1.39575015409902 0.0813948727050859 no 434 0.0422030878044057 213 NA FT CELL CYCLE|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION NUCLEUS Putative protein serine/threonine kinase expressed at the end of meiosis and localized to the prospore membrane, required for correct localization of enzymes involved in spore wall synthesis ascospore wall assembly|ascospore formation|protein phosphorylation protein serine/threonine kinase activity|protein kinase activity nucleus|prospore membrane|cytoplasm
YDR213W YDR213W UPC2 hom Verified 1.39421473894958 0.0816263842230181 no 435 0.0879842648730447 363 NA FT TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM NUCLEUS Sterol regulatory element binding protein; induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; relocates from intracellular membranes to perinuclear foci on sterol depletion; UPC2 has a paralog, ECM22, that arose from the whole genome duplication cellular response to hypoxia|positive regulation of ergosterol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus|membrane|cytoplasm|perinuclear region of cytoplasm
YBR009C YBR009C HHF1 hom Verified 1.39412774070203 0.0816395167577619 no 436 0.0772399117979543 348 NA FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Histone H4, core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity chromatin assembly or disassembly|sexual sporulation resulting in formation of a cellular spore|histone H3-K79 methylation DNA binding replication fork protection complex|nuclear nucleosome
YDL155W YDL155W CLB3 hom Verified 1.39055186802625 0.0821806802472713 no 437 0.0795233105074811 293 NA FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION NUCLEUS B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress G2/M transition of mitotic cell cycle|S phase of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|positive regulation of spindle pole body separation cyclin-dependent protein kinase regulator activity nucleus|cytoplasm
YIL163C_p YIL163C YIL163C hom Uncharacterized 1.38977902774748 0.0822979942244225 no 438 0.069667190296084 313 NA Protein of unknown function; mRNA identified as translated by ribosome profiling data biological_process molecular_function cellular_component
YLR039C YLR039C RIC1 hom Verified 1.38907080815576 0.0824056097458311 no 439 0.181876698192418 585 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes intracellular protein transport|retrograde transport, endosome to Golgi guanyl-nucleotide exchange factor activity nucleus|Ric1p-Rgp1p complex|Golgi membrane|guanyl-nucleotide exchange factor complex
YML082W_p YML082W YML082W hom Uncharacterized 1.38371791706742 0.0832224225866433 no 440 0.108881184854451 383 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Putative protein predicted to have carbon-sulfur lyase activity; transcriptionally regulated by Upc2p via an upstream sterol response element; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and the cytoplasm; YML082W is not an essential gene sulfur compound metabolic process carbon-sulfur lyase activity nucleus|cytoplasm
YML016C YML016C PPZ1 hom Verified 1.38319432834781 0.0833026441657942 no 441 0.101010169968614 342 NA FT PROTEIN LOCALIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS NUCLEUS|PLASMA MEMBRANE Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance cellular sodium ion homeostasis|cellular protein localization|protein dephosphorylation protein serine/threonine phosphatase activity extrinsic to plasma membrane|nucleus|cytoplasm
YDL045W-A YDL045W-A MRP10 hom Verified 1.381225583135 0.0836048055030189 no 442 0.118787478285502 390 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit; contains twin cysteine-x9-cysteine motifs mitochondrial translation|mitochondrial respiratory chain complex assembly structural constituent of ribosome mitochondrial small ribosomal subunit
YPR156C YPR156C TPO3 hom Verified 1.38053249496426 0.0837113758440521 no 443 0.0674026982889165 322 NA FT PLASMA MEMBRANE Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; TPO3 has a paralog, TPO2, that arose from the whole genome duplication spermine transport spermine transmembrane transporter activity fungal-type vacuole membrane|integral to membrane|plasma membrane
YBR090C_p YBR090C YBR090C hom Uncharacterized 1.380350779819 0.0837393335323756 no 444 0.0649660735653236 267 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus biological_process molecular_function nucleus|cytoplasm
YLR377C YLR377C FBP1 hom Verified 1.38029363620644 0.0837481267824106 no 445 0.0878115958132533 344 NA FT CARBOHYDRATE METABOLISM Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism; undergoes either proteasome-mediated or autophagy-mediated degradation depending on growth conditions; interacts with Vid30p gluconeogenesis|reactive oxygen species metabolic process fructose 1,6-bisphosphate 1-phosphatase activity cytosol
YLR102C YLR102C APC9 hom Verified 1.37996681299586 0.083798431614438 no 446 0.0725612574358788 301 NA FT CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION NUCLEUS UBIQUITIN LIGASE COMPLEX Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition chromatin assembly|protein ubiquitination ubiquitin-protein ligase activity anaphase-promoting complex
YKR036C YKR036C CAF4 hom Verified 1.37705725984847 0.0842472726831527 no 447 0.0768145207744173 338 NA FT TRANSCRIPTION FROM RNA POL II|MITOCHONDRION ORGANIZATION|PEROXISOME ORGANIZATION NUCLEUS|MITOCHONDRION WD40 repeat-containing protein associated with the CCR4-NOT complex; interacts in a Ccr4p-dependent manner with Ssn2p; also interacts with Fis1p, Mdv1p and Dnm1p and plays a role in mitochondrial fission; CAF4 has a paralog, MDV1, that arose from the whole genome duplication peroxisome fission|mitochondrial fission|regulation of transcription from RNA polymerase II promoter molecular_function mitochondrion|CCR4-NOT complex
YLR408C_p YLR408C BLS1 hom Uncharacterized 1.37575373487436 0.0844489447357299 no 448 0.0681307075180008 265 NA Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene biological_process molecular_function endosome|BLOC-1 complex
YDR099W YDR099W BMH2 hom Verified 1.37566583816923 0.0844625565087079 no 449 0.0937933729519181 307 NA FT CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS 14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress glycogen metabolic process|ascospore formation|Ras protein signal transduction|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|DNA damage checkpoint|DNA replication initiation|signal transduction involved in filamentous growth|pseudohyphal growth|fungal-type cell wall chitin biosynthetic process|pre-replicative complex assembly DNA replication origin binding|phosphoserine binding nucleus|plasma membrane
YLR381W YLR381W CTF3 hom Verified 1.37519935448655 0.0845348241959285 no 450 0.0663191434722133 314 NA FT CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME KINETOCHORE Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p; may bind the kinetochore to spindle microtubules; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-I and fission yeast mis6 chromosome segregation|DNA replication initiation|establishment of mitotic sister chromatid cohesion molecular_function condensed nuclear chromosome kinetochore
YBR045C YBR045C GIP1 hom Verified 1.37489269412167 0.0845823573057775 no 451 0.0975544242637754 411 NA FT CELL WALL ORG/BIOGENESIS Meiosis-specific regulatory subunit of the Glc7p protein phosphatase, regulates spore wall formation and septin organization, required for expression of some late meiotic genes and for normal localization of Glc7p ascospore wall assembly|regulation of phosphoprotein phosphatase activity protein phosphatase type 1 regulator activity|protein phosphatase 1 binding protein phosphatase type 1 complex|prospore membrane
YGR080W YGR080W TWF1 hom Verified 1.37398500166312 0.0847231693587006 no 452 0.0734659333863165 302 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Twinfilin, highly conserved actin monomer-sequestering protein involved in regulation of the cortical actin cytoskeleton, composed of two cofilin-like regions, localizes actin monomers to sites of rapid filament assembly bipolar cellular bud site selection|actin polymerization or depolymerization|sequestering of actin monomers actin monomer binding mating projection tip|actin cortical patch
YNL173C YNL173C MDG1 hom Verified 1.37277531517076 0.0849111034830186 no 453 0.0976082048047429 401 NA FT SIGNALING PLASMA MEMBRANE Plasma membrane protein involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations pheromone-dependent signal transduction involved in conjugation with cellular fusion molecular_function membrane raft|plasma membrane
YBR278W YBR278W DPB3 hom Verified 1.37153360131398 0.0851043381693918 no 454 0.0909130084734645 356 NA FT RESPONSE TO DNA DAMAGE|GENE SILENCING NUCLEUS|CHROMOSOME Third-largest subunit of DNA polymerase II (DNA polymerase epsilon); required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; mRNA abundance peaks at the G1/S boundary of the cell cycle; DPB3 has a paralog, DLS1, that arose from the whole genome duplication DNA-dependent DNA replication|chromatin silencing at telomere double-stranded DNA binding|single-stranded DNA binding|DNA-directed DNA polymerase activity epsilon DNA polymerase complex
YBR233W YBR233W PBP2 hom Verified 1.37147579179467 0.0851133424704334 no 455 0.0891418073180569 322 NA FT NUCLEUS RNA binding protein; has similarity to mammalian heterogeneous nuclear RNP K protein, involved in the regulation of telomere position effect and telomere length; relative distribution to the nucleus increases upon DNA replication stress telomere maintenance via telomere shortening mRNA binding cytoplasm
YLR043C YLR043C TRX1 hom Verified 1.36983322593779 0.0853694838406077 no 456 0.0818186232090228 383 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance; protein abundance increases in response to DNA replication stress vacuole inheritance|regulation of DNA replication|cell redox homeostasis|protein deglutathionylation|retrograde vesicle-mediated transport, Golgi to ER|cellular response to oxidative stress|ER to Golgi vesicle-mediated transport|vacuole fusion, non-autophagic disulfide oxidoreductase activity cytosol|fungal-type vacuole
YPR067W YPR067W ISA2 hom Verified 1.36768101184689 0.0857059730263419 no 457 0.114497340505782 444 NA FT KETONE METABOLISM|COFACTOR METABOLISM MITOCHONDRION Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa1p and possibly Iba57p; localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations iron-sulfur cluster assembly|biotin biosynthetic process iron ion binding mitochondrion|mitochondrial intermembrane space
YDL018C YDL018C ERP3 hom Verified 1.36754256129793 0.0857276531023557 no 458 0.101744578063043 319 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport vesicle-mediated transport molecular_function integral to membrane
YDR465C YDR465C RMT2 hom Verified 1.36608473632861 0.0859561842752948 no 459 0.1074129985773 309 NA FT NUCLEUS Arginine N5 methyltransferase; methylates ribosomal protein Rpl12 (L12) on Arg67; relative distribution to the nucleus increases upon DNA replication stress peptidyl-arginine methylation protein-arginine N5-methyltransferase activity nucleus|cytoplasm
YDR101C YDR101C ARX1 hom Verified 1.36377276691328 0.0863195469398924 no 460 0.095622614596256 307 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|PROTEOLYSIS NUCLEUS RIBOSOME Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex ribosomal large subunit biogenesis molecular_function nucleoplasm|cytosolic large ribosomal subunit|cytoplasm
YPR060C YPR060C ARO7 hom Verified 1.36339163897413 0.0863795573696829 no 461 0.133523663600531 539 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Chorismate mutase, catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis aromatic amino acid family biosynthetic process chorismate mutase activity nucleus|cytoplasm
YNL027W YNL027W CRZ1 hom Verified 1.36309032679092 0.0864270225009137 no 462 0.0764307139372658 276 NA FT TRANSCRIPTION FROM RNA POL II|SIGNALING|ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|ION HOMEOSTASIS NUCLEUS Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress regulation of potassium ion concentration by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter in response to calcium ion|positive regulation of sodium ion transport by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter in response to increased salt|cell wall chitin biosynthetic process|positive regulation of transcription from RNA polymerase II promoter in response to alkalinity|positive regulation of transcription from RNA polymerase II promoter by pheromones|ion homeostasis|Unknown|positive regulation of transcription from RNA polymerase II promoter core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus|cytoplasm
YOL091W YOL091W SPO21 hom Verified 1.36168747954343 0.0866482671223737 no 463 0.0756125067276982 345 NA FT CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION CYTOSKELETON Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation ascospore wall assembly|meiosis structural molecule activity spindle pole body
YEL024W YEL024W RIP1 hom Verified 1.35763162342997 0.0872903016413815 no 464 0.11390365275773 434 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Ubiquinol-cytochrome-c reductase, a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration; during import, Rip1p is first imported into the mitochondrial matrix where it is processed, acquires its Fe-S cluster, and is folded, then is translocated into the inner membrane by the action of a homo-oligomer of Bcs1p, and finally is delivered by Bcs1p to Complex III for assembly mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration ubiquinol-cytochrome-c reductase activity mitochondrion|mitochondrial respiratory chain complex III
YAR031W YAR031W PRM9 hom Verified 1.35676141239471 0.0874285160341968 no 465 0.0926593857866737 328 NA FT VESICLE-MEDIATED TRANSPORT ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Pheromone-regulated protein with 3 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; member of DUP240 gene family vesicle organization molecular_function integral to membrane|endoplasmic reticulum|plasma membrane
YNL096C YNL096C RPS7B hom Verified 1.35329598297778 0.0879805460013846 no 466 0.100444778153039 402 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION NUCLEUS RIBOSOME Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7B has a paralog, RPS7A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress cytoplasmic translation|ribosome biogenesis structural constituent of ribosome small-subunit processome|cytosolic small ribosomal subunit
YGR241C YGR241C YAP1802 hom Verified 1.35126422555738 0.0883054037178494 no 467 0.100052834118832 412 NA FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1802 has a paralog, YAP1801, that arose from the whole genome duplication endocytosis clathrin binding actin cortical patch
YIL161W_p YIL161W YIL161W hom Uncharacterized 1.35041199101501 0.0884419333215132 no 468 0.0687994949555318 309 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; mRNA is enriched in Scp160p-associated mRNPs; YIL161W is a non-essential gene biological_process molecular_function cytoplasm
YJL016W_p YJL016W YJL016W hom Uncharacterized 1.35019237775343 0.0884771412596128 no 469 0.0973054175662584 363 NA Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; conserved in closely related Saccharomyces species biological_process molecular_function cytoplasm
YML020W_p YML020W YML020W hom Uncharacterized 1.34963859384636 0.0885659691000338 no 470 0.0874529823762056 378 NA Putative protein of unknown function biological_process molecular_function cellular_component
YNR020C YNR020C ATP23 hom Verified 1.34947467930427 0.0885922739969726 no 471 0.107629672811795 379 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Putative metalloprotease of the mitochondrial inner membrane, required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex; substrate of the Mia40p-Erv1p disulfide relay system, and folding is assisted by Mia40p protein processing|mitochondrial proton-transporting ATP synthase complex assembly metalloendopeptidase activity mitochondrial inner membrane|mitochondrial intermembrane space
YLR044C YLR044C PDC1 hom Verified 1.34706865880585 0.0889790604862467 no 472 0.102022129491718 426 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde; subject to glucose-, ethanol-, and autoregulation; involved in amino acid catabolism L-phenylalanine catabolic process|pyruvate metabolic process|glucose catabolic process to ethanol|tryptophan catabolic process|aromatic amino acid family catabolic process to alcohol via Ehrlich pathway pyruvate decarboxylase activity cytosol|nucleus|cytoplasm
YDL178W YDL178W DLD2 hom Verified 1.34691211733203 0.0890042692297361 no 473 0.126272227799018 467 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION D-lactate dehydrogenase, located in the mitochondrial matrix lactate metabolic process actin binding|D-lactate dehydrogenase (cytochrome) activity mitochondrion|mitochondrial matrix
YJL189W YJL189W RPL39 hom Verified 1.3422374474701 0.0897595090572257 no 474 0.0946030884816851 356 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YOR200W_d YOR200W YOR200W hom Dubious 1.33968425293385 0.090174009605009 no 475 0.139652865182257 532 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRM1/YOR201c Unknown Unknown Unknown
YBR216C YBR216C YBP1 hom Verified 1.33152750459129 0.0915077505175939 no 476 0.0838178910269491 273 NA FT RESPONSE TO OXIDATIVE STRESS Protein involved in cellular response to oxidative stress; required for oxidation of specific cysteine residues of transcription factor Yap1p, resulting in nuclear localization of Yap1p in response to stress; YBP1 has a paralog, YBP2, that arose from the whole genome duplication cellular response to oxidative stress molecular_function cytoplasm
YGL180W YGL180W ATG1 hom Verified 1.32945465704848 0.0918490078769391 no 477 0.083017769821876 327 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Protein ser/thr kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for phagophore assembly site formation; during autophagy forms a complex with Atg13p and Atg17p piecemeal microautophagy of nucleus|mitochondrion degradation|protein phosphorylation|CVT pathway|autophagic vacuole assembly protein serine/threonine kinase activity|protein kinase activity cytosol|pre-autophagosomal structure|Atg1p signaling complex
YIL100W_d YIL100W YIL100W hom Dubious 1.32910337613803 0.0919069332978533 no 478 0.100726076700525 272 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YIL100C-A Unknown Unknown Unknown
YGL104C YGL104C VPS73 hom Verified 1.32722925281648 0.0922164292354611 no 479 0.106374663250562 390 NA FT PROTEIN LOCALIZATION|VACUOLAR TRANSPORT MITOCHONDRION Mitochondrial protein; mutation affects vacuolar protein sorting; putative transporter; member of the sugar porter family transport|transmembrane transport|protein targeting to vacuole substrate-specific transmembrane transporter activity mitochondrion|integral to membrane
YML005W YML005W TRM12 hom Verified 1.32181970654189 0.0931140972793476 no 480 0.107378688443068 373 NA FT RNA PROCESSING S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; required for wybutosine formation in phenylalanine-accepting tRNA wybutosine biosynthetic process|tRNA methylation S-adenosylmethionine-dependent methyltransferase activity|transferase activity, transferring alkyl or aryl (other than methyl) groups cytoplasm
YKL205W YKL205W LOS1 hom Verified 1.31894825158658 0.0935932066628964 no 481 0.0974396076584351 319 NA FT RNA PROCESSING|RNA LOCALIZATION NUCLEUS|MITOCHONDRION Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm tRNA re-export from nucleus|tRNA splicing, via endonucleolytic cleavage and ligation|tRNA export from nucleus tRNA binding|Ran GTPase binding mitochondrion|integral to membrane|nuclear matrix|cytoplasm
YNL214W YNL214W PEX17 hom Verified 1.31551326103204 0.0941687317680358 no 482 0.107659863888034 406 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PEROXISOME ORGANIZATION Peroxisomal membrane peroxin and subunit of the docking complex that facilitates the import of peroxisomal matrix proteins; required for peroxisome biogenesis protein import into peroxisome matrix, docking protein binding peroxisomal membrane
YHR086W-A_p YHR086W-A YHR086W-A hom Uncharacterized 1.31511344315557 0.0942358896301616 no 483 0.0882618630419411 354 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YPR149W YPR149W NCE102 hom Verified 1.31381006078335 0.094455065542258 no 484 0.0802926849773496 348 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION ENDOPLASMIC RETICULUM|MITOCHONDRION|PLASMA MEMBRANE Protein of unknown function; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs) eisosome assembly|protein secretion|negative regulation of protein phosphorylation|plasma membrane organization|establishment of protein localization to plasma membrane molecular_function mitochondrion|integral to membrane|membrane raft|endoplasmic reticulum|cellular bud membrane|plasma membrane|mating projection membrane|cytoplasm
YMR205C YMR205C PFK2 hom Verified 1.31224086832569 0.0947194382855189 no 485 0.162585063332222 629 NA FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes proton transport|glycolysis mRNA binding|6-phosphofructokinase activity mitochondrion|6-phosphofructokinase complex|cytoplasm
YPL026C YPL026C SKS1 hom Verified 1.31107395753835 0.094916389116062 no 486 0.0506898766877719 234 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN PHOSPHORYLATION NUCLEUS Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway glucose transport|protein phosphorylation|response to glucose stimulus|positive regulation of transcription from RNA polymerase II promoter protein serine/threonine kinase activity|protein kinase activity nucleus|cytoplasm
YCR075C YCR075C ERS1 hom Verified 1.31058211078756 0.094999493178957 no 487 0.0831542203061632 383 NA Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains L-cystine transport|transmembrane transport L-cystine transmembrane transporter activity endosome|integral to membrane|fungal-type vacuole
YDR063W YDR063W AIM7 hom Verified 1.30780697485674 0.0954693939417846 no 488 0.0752563348832536 287 NA FT CYTOSKELETON ORGANIZATION NUCLEUS|CYTOSKELETON Protein that interacts with Arp2/3 complex to stimulate actin filament debranching and inhibit actin nucleation; has similarity to Cof1p and also to human glia maturation factor (GMF); null mutant displays elevated mitochondrial genome loss actin filament debranching|negative regulation of Arp2/3 complex-mediated actin nucleation molecular_function nucleus|actin cortical patch|cytoplasm
YIR027C YIR027C DAL1 hom Verified 1.30776045518297 0.0954772854530566 no 489 0.109083242039195 393 NA Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression allantoin assimilation pathway allantoinase activity cellular_component
YKR064W YKR064W OAF3 hom Verified 1.30515053358052 0.0959207971388799 no 490 0.108193764721586 374 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS|MITOCHONDRION Putative transcriptional repressor with Zn(2)-Cys(6) finger; negatively regulates transcription in response to oleate levels, based on mutant phenotype and localization to oleate-responsive promoters; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress negative regulation of transcription from RNA polymerase II promoter|cellular response to oleic acid RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity mitochondrion|nucleus|cytoplasm
YJL218W_p YJL218W YJL218W hom Uncharacterized 1.30142469118404 0.0965565632987097 no 491 0.0973516943021541 406 NA Putative acetyltransferase; similar to bacterial galactoside O-acetyltransferases; induced by oleate in an OAF1/PIP2-dependent manner; promoter contains an oleate response element consensus sequence; non-essential gene biological_process acetyltransferase activity cellular_component
YKL157W YKL157W APE2 hom Verified 1.29827869197117 0.0970957928557433 no 492 0.103893827717302 354 NA FT PROTEOLYSIS MITOCHONDRION Aminopeptidase yscII; may have a role in obtaining leucine from dipeptide substrates; APE2 has a paralog, AAP1, that arose from the whole genome duplication peptide catabolic process metalloaminopeptidase activity mitochondrion|extracellular region|cell wall-bounded periplasmic space
YHR139C YHR139C SPS100 hom Verified 1.29712580374205 0.0972939522085213 no 493 0.108061631148102 432 NA FT KETONE METABOLISM|CELL CYCLE|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall; expression also induced in cells treated with the mycotoxin patulin ascospore wall assembly molecular_function ascospore wall
YPL185W_d YPL185W YPL185W hom Dubious 1.29463565879049 0.0977229725821236 no 494 0.103784838950701 333 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C Unknown Unknown Unknown
YCR089W YCR089W FIG2 hom Verified 1.29372786318624 0.0978797187171901 no 495 0.0773094068099109 285 NA FT CELL WALL ORG/BIOGENESIS Cell wall adhesin, expressed specifically during mating; may be involved in maintenance of cell wall integrity during mating filamentous growth of a population of unicellular organisms|cell morphogenesis involved in conjugation with cellular fusion|invasive growth in response to glucose limitation|cytogamy molecular_function fungal-type cell wall|mating projection
YOR229W YOR229W WTM2 hom Verified 1.29370440395155 0.0978837717886172 no 496 0.0939214290820723 376 NA FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RESPONSE TO DNA DAMAGE|GENE SILENCING NUCLEUS Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; involved in response to replication stress; contains WD repeats negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of transcription from RNA polymerase II promoter during meiosis|cellular protein complex localization|negative regulation of chromatin silencing at telomere|response to DNA damage stimulus|positive regulation of transcription from RNA polymerase II promoter protein binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|transcription corepressor activity nucleus
YDR069C YDR069C DOA4 hom Verified 1.29150159212477 0.0982649016930392 no 497 0.118436761123363 490 NA FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|PROTEOLYSIS MITOCHONDRION Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole protein deubiquitination|endocytosis|regulation of DNA replication|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|free ubiquitin chain depolymerization|ubiquitin homeostasis|ubiquitin-dependent protein catabolic process endopeptidase activity|ubiquitin-specific protease activity|ubiquitin thiolesterase activity endosome|proteasome complex|mitochondrion
YMR015C YMR015C ERG5 hom Verified 1.28984862334821 0.0985516109425706 no 498 0.150146657286049 579 NA FF|FT LIPID METABOLISM|OXIDATION-REDUCTION PROCESS ENDOPLASMIC RETICULUM C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs ergosterol biosynthetic process C-22 sterol desaturase activity endoplasmic reticulum
YBR036C YBR036C CSG2 hom Verified 1.28934362336741 0.0986393257550377 no 499 0.138886637379432 550 NA FF|FT LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Endoplasmic reticulum membrane protein, required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations; protein abundance increases in response to DNA replication stress cellular calcium ion homeostasis|glycosphingolipid biosynthetic process enzyme regulator activity integral to endoplasmic reticulum membrane|integral to membrane
YPL041C_p YPL041C YPL041C hom Uncharacterized 1.28877028739024 0.0987389792831648 no 500 0.0949577960677819 290 NA Protein of unknown function involved in maintenance of proper telomere length biological_process molecular_function cellular_component
YOR097C_p YOR097C YOR097C hom Uncharacterized 1.28572524408544 0.0992694839298487 no 501 0.120153245255869 489 NA Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; YOR097C is not an essential gene biological_process molecular_function cellular_component
YLR385C YLR385C SWC7 hom Verified 1.28450101331416 0.099483354627245 no 502 0.0942594350193783 343 NA FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin chromatin remodeling molecular_function Swr1 complex|nucleus
YDR306C_p YDR306C YDR306C hom Uncharacterized 1.28282534069731 0.0997766370052989 no 503 0.116306504882637 399 NA FT PROTEOLYSIS F-box protein of unknown function; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity|protein binding, bridging SCF ubiquitin ligase complex
YOR161C YOR161C PNS1 hom Verified 1.28198692759373 0.0999236159997887 no 504 0.104550779661216 415 NA FT PLASMA MEMBRANE Protein of unknown function; has similarity to Torpedo californica tCTL1p, which is postulated to be a choline transporter, neither null mutation nor overexpression affects choline transport biological_process choline transmembrane transporter activity|molecular_function integral to membrane|plasma membrane|integral to plasma membrane
YOR186W_p YOR186W YOR186W hom Uncharacterized 1.27979179748098 0.10030918471108 no 505 0.0919831740851734 366 NA Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent; YOR186W has a paralog, YLR297W, that arose from the whole genome duplication biological_process molecular_function cellular_component
YKR096W YKR096W ESL2 hom Verified 1.27904644886848 0.100440349817024 no 506 0.107674579133228 388 NA FT NUCLEUS Protein of unknown function that interacts with Pex14p; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; predicted to contain a PINc domain biological_process molecular_function ribosome|nucleus|cytoplasm
YKL124W YKL124W SSH4 hom Verified 1.27785783128928 0.100649779445268 no 507 0.060879896213925 297 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT Specificity factor required for Rsp5p-dependent ubiquitination and sorting of cargo proteins at the multivesicular body; identified as a high-copy suppressor of a SHR3 deletion, increasing steady-state levels of amino acid permeases protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|vesicle-mediated transport molecular_function fungal-type vacuole
YNL199C YNL199C GCR2 hom Verified 1.27414805770101 0.101305474743186 no 508 0.117643761394733 458 NA FT TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY ENDOMEMBRANE SYSTEM|NUCLEUS Transcriptional activator of genes involved in glycolysis; interacts and functions with the DNA-binding protein Gcr1p positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter|regulation of glycolysis by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II activating transcription factor binding|RNA polymerase II transcription factor binding transcription factor activity nuclear envelope|nucleus
YDL190C YDL190C UFD2 hom Verified 1.27392411520416 0.101345155517719 no 509 0.109371800137399 400 NA FT PROTEOLYSIS NUCLEUS Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3 ER-associated protein catabolic process|protein ubiquitination|ubiquitin-dependent protein catabolic process|response to stress ubiquitin-ubiquitin ligase activity nucleus|cytoplasm
YPL018W YPL018W CTF19 hom Verified 1.27190012799286 0.101704303190923 no 510 0.113141676320232 434 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME KINETOCHORE Outer kinetochore protein, needed for accurate chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-P and fission yeast fta2 attachment of spindle microtubules to kinetochore|chromosome segregation|establishment of mitotic sister chromatid cohesion molecular_function COMA complex|condensed nuclear chromosome kinetochore|nucleus
YFL042C_p YFL042C YFL042C hom Uncharacterized 1.27133825659834 0.101804168940334 no 511 0.107241093023416 340 NA Putative protein of unknown function; YFL042C is not an essential gene biological_process molecular_function cellular_component
YMR007W_d YMR007W YMR007W hom Dubious 1.26786388557743 0.102423281486284 no 512 0.0682037237370373 297 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDL061C YDL061C RPS29B hom Verified 1.26626339514628 0.102709398760872 no 513 0.0916756021476611 374 NA FT TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29B has a paralog, RPS29A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic small ribosomal subunit
YLR366W_d YLR366W YLR366W hom Dubious 1.26543686632244 0.102857383328929 no 514 0.102754932733821 380 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR364C-A Unknown Unknown Unknown
YLR120C YLR120C YPS1 hom Verified 1.26445130139088 0.103034044698661 no 515 0.122554672248921 411 NA FT CELL WALL ORG/BIOGENESIS|PROTEOLYSIS PLASMA MEMBRANE Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor fungal-type cell wall organization|protein processing aspartic-type endopeptidase activity fungal-type cell wall
YML034W YML034W SRC1 hom Verified 1.26442083284557 0.103039509659922 no 516 0.132764176536202 522 NA FF|FT CELL CYCLE|CHROMOSOME SEGREGATION ENDOMEMBRANE SYSTEM|NUCLEUS Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance maintenance of rDNA|mitotic sister chromatid segregation molecular_function nuclear envelope
YEL044W YEL044W IES6 hom Verified 1.2641789197671 0.103082907638411 no 517 0.124469626024383 508 NA FT NUCLEUS Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions; human ortholog INO80C is a member of the human INO80 complex; implicated in DNA repair based on genetic interactions with RAD52 epistasis genes biological_process molecular_function nucleus
YLR420W YLR420W URA4 hom Verified 1.2636389639727 0.103179820848959 no 518 0.112784032186985 413 NA FT NUCLEOTIDE METABOLISM NUCLEUS Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate 'de novo' pyrimidine nucleobase biosynthetic process|pyrimidine nucleotide biosynthetic process dihydroorotase activity nucleus|cytoplasm
YOL027C YOL027C MDM38 hom Verified 1.26342757029574 0.103217780564194 no 519 0.11280971067038 399 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|TRANSLATION|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS MITOCHONDRION Mitochondrial protein, forms a complex with Mba1p to facilitate recruitment of mRNA-specific translational activators to ribosomes; roles in protein export and K+/H+ exchange; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome potassium ion transport|mitochondrial respiratory chain complex III biogenesis|cellular potassium ion homeostasis|proton transport|positive regulation of mitochondrial translation|mitochondrial respiratory chain complex IV biogenesis|protein insertion into mitochondrial membrane ribosome binding mitochondrion|mitochondrial inner membrane
YMR166C_p YMR166C YMR166C hom Uncharacterized 1.26315282192261 0.103267131961559 no 520 0.112867648736644 464 NA FT MITOCHONDRION Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene transport transporter activity integral to membrane|mitochondrial inner membrane
YLR014C YLR014C PPR1 hom Verified 1.26103728268925 0.103647707481249 no 521 0.13659571412651 443 NA FT TRANSCRIPTION FROM RNA POL II|NUCLEOTIDE METABOLISM NUCLEUS Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of URA1, URA3, URA4, and URA10, which are involved in de novo pyrimidine biosynthesis, in response to pyrimidine starvation; activity may be modulated by interaction with Tup1p positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding RNA polymerase II transcription factor activity|sequence-specific DNA binding|zinc ion binding nucleus
YBR206W_d YBR206W YBR206W hom Dubious 1.26064707050534 0.103718015835287 no 522 0.116994336240753 426 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KTR3 Unknown Unknown Unknown
YDR079C-A YDR079C-A TFB5 hom Verified 1.26061183624405 0.103724366040305 no 523 0.101837880649881 444 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION NUCLEUS RNA POL II, HOLOENZYME Component of the RNA polymerase II general transcription and DNA repair factor TFIIH; involved in transcription initiation and in nucleotide-excision repair; homolog of Chlamydomonas reinhardtii REX1-S protein involved in DNA repair phosphorylation of RNA polymerase II C-terminal domain|nucleotide-excision repair|transcription from RNA polymerase II promoter core RNA polymerase binding transcription factor activity core TFIIH complex|holo TFIIH complex|nucleus
YBR084C-A YBR084C-A RPL19A hom Verified 1.26047330562826 0.103749335888744 no 524 0.103608337617158 389 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L19A; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19A has a paralog, RPL19B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YDL109C_p YDL109C YDL109C hom Uncharacterized 1.25992412364047 0.103848367682752 no 525 0.11280774857734 485 NA FT LIPID METABOLISM Putative lipase; involved in lipid metabolism; not an essential gene; YDL109C has a paralog, ROG1, that arose from the whole genome duplication cellular lipid metabolic process molecular_function cellular_component
YDL175C YDL175C AIR2 hom Verified 1.25930545219271 0.103960012339715 no 526 0.112935849126346 408 NA FT RNA PROCESSING NUCLEUS RNA-binding subunit of the TRAMP nuclear RNA surveillance complex; involved in nuclear RNA processing and degradation; involved in TRAMP complex assembly as a bridge between Mtr4p and Trf4p; stimulates the poly(A) polymerase activity of Pap2p in vitro; has 5 zinc knuckle motifs; AIR2 has a paralog, AIR1, that arose from the whole genome duplication nuclear polyadenylation-dependent CUT catabolic process|nuclear mRNA surveillance of mRNA 3'-end processing|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent snRNA catabolic process|ncRNA polyadenylation|tRNA modification polynucleotide adenylyltransferase activity|RNA binding|protein binding, bridging nucleolus|TRAMP complex
YLR306W YLR306W UBC12 hom Verified 1.25836159977616 0.104130506386679 no 527 0.0877523030096417 330 NA Enzyme that mediates the conjugation of Rub1p, a ubiquitin-like protein, to other proteins; related to E2 ubiquitin-conjugating enzymes protein neddylation NEDD8 ligase activity cellular_component
YLR221C YLR221C RSA3 hom Verified 1.25700605234748 0.104375721997156 no 528 0.0974152147816907 346 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS NUCLEUS Protein with a likely role in ribosomal maturation, required for accumulation of wild-type levels of large (60S) ribosomal subunits; binds to the helicase Dbp6p in pre-60S ribosomal particles in the nucleolus ribosomal large subunit assembly molecular_function nucleolus|preribosome, large subunit precursor
YDR197W YDR197W CBS2 hom Verified 1.25636332867586 0.104492135455988 no 529 0.136840485164653 467 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial translational activator of the COB mRNA; interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader mitochondrial respiratory chain complex III biogenesis|positive regulation of mitochondrial translation translation regulator activity mitochondrion|extrinsic to mitochondrial inner membrane|mitochondrial ribosome
YBR092C YBR092C PHO3 hom Verified 1.25538964525202 0.104668673224307 no 530 0.0870671205065907 353 NA Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin phosphate-containing compound metabolic process|thiamine-containing compound metabolic process acid phosphatase activity cell wall-bounded periplasmic space
YKL026C YKL026C GPX1 hom Verified 1.25533631360182 0.104678348979858 no 531 0.108659206389042 411 NA FT OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress cellular response to oxidative stress|peroxisome organization phospholipid-hydroperoxide glutathione peroxidase activity|glutathione peroxidase activity extrinsic to mitochondrial outer membrane|peroxisomal matrix
YOL159C-A YOL159C-A YOL159C-A hom Verified 1.25468894632163 0.104795849989476 no 532 0.0809442974161974 359 NA FT NUCLEUS Protein of unknown function; overexpression affects endocytic protein trafficking; identified by sequence comparison with hemiascomycetous yeast species biological_process molecular_function nucleus|cytoplasm
YPL250C YPL250C ICY2 hom Verified 1.25443760070929 0.10484149644221 no 533 0.121905509579385 452 NA Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate mitochondrion degradation molecular_function cellular_component
YHR199C YHR199C AIM46 hom Verified 1.25378187255728 0.104960649892652 no 534 0.160221946606765 536 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss biological_process molecular_function mitochondrion
YPR172W_p YPR172W YPR172W hom Uncharacterized 1.25281789851508 0.105135993155455 no 535 0.0987981463059128 455 NA FT OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM NUCLEUS Putative pyridoxal 5'-phosphate synthase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; YPR172W has a paralog, YLR456W, that arose from the whole genome duplication biological_process molecular_function nucleus|cytoplasm
YML009W-B_d YML009W-B YML009W-B hom Dubious 1.2523318039063 0.105224492298306 no 536 0.108344555821114 435 NA Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition Unknown Unknown Unknown
YGL156W YGL156W AMS1 hom Verified 1.25227758779725 0.10523436630799 no 537 0.101911203846731 377 NA FT CARBOHYDRATE METABOLISM Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway oligosaccharide catabolic process|cellular carbohydrate metabolic process alpha-mannosidase activity fungal-type vacuole membrane
YLR019W YLR019W PSR2 hom Verified 1.25090767674309 0.105484081377332 no 538 0.103506408490065 370 NA FT PLASMA MEMBRANE Functionally redundant Psr1p homolog, a plasma membrane phosphatase involved in the general stress response; required with Psr1p and Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p response to stress phosphoprotein phosphatase activity plasma membrane
YGR061C YGR061C ADE6 hom Verified 1.2476804665841 0.106074048721502 no 539 0.113366267705618 396 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM Formylglycinamidine-ribonucleotide (FGAM)-synthetase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway 'de novo' IMP biosynthetic process|purine nucleotide biosynthetic process phosphoribosylformylglycinamidine synthase activity cytoplasm
YKL016C YKL016C ATP7 hom Verified 1.24380747790058 0.106785213776092 no 540 0.11314594667892 434 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS MITOCHONDRION Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis protein complex assembly|ATP synthesis coupled proton transport hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism mitochondrion|mitochondrial proton-transporting ATP synthase, stator stalk|integral to membrane|mitochondrial proton-transporting ATP synthase complex
YBL099W YBL099W ATP1 hom Verified 1.23982654204926 0.10751977936633 no 541 0.120328426270844 493 NA FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS MITOCHONDRION Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated ATP synthesis coupled proton transport hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism mitochondrial nucleoid|proton-transporting ATP synthase complex, catalytic core F(1)|mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase, catalytic core
YBR025C YBR025C OLA1 hom Verified 1.23962449778575 0.1075571576014 no 542 0.109983460949989 438 NA P-loop ATPase with similarity to human OLA1 and bacterial YchF; identified as specifically interacting with the proteasome; protein abundance increases in response to hydrogen peroxide and to DNA replication stress biological_process ATPase activity cytoplasm
YDR417C_d YDR417C YDR417C hom Dubious 1.23683865669061 0.108073493766225 no 543 0.116106219668606 401 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RPL12B/YDR418W Unknown Unknown Unknown
YAR002W YAR002W NUP60 hom Verified 1.23495204184921 0.108424176632713 no 544 0.128099666116513 454 NA FT PROTEIN LOCALIZATION|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; both NUP1 and NUP60 are homologous to human NUP153 double-strand break repair|poly(A)+ mRNA export from nucleus|protein export from nucleus|regulation of protein desumoylation|intracellular mRNA localization|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|telomere tethering at nuclear periphery|mRNA export from nucleus in response to heat stress|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery|NLS-bearing substrate import into nucleus|chromosome organization|nucleocytoplasmic transport|chromatin silencing at silent mating-type cassette nucleocytoplasmic transporter activity|phospholipid binding|structural constituent of nuclear pore nuclear pore central transport channel|nuclear pore nuclear basket|integral to membrane|nuclear pore
YGL186C YGL186C TPN1 hom Verified 1.23490303615287 0.108433296680071 no 545 0.236370802485853 819 NA FF|FT PLASMA MEMBRANE Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p vitamin transport vitamin transporter activity integral to membrane|plasma membrane
YDL066W YDL066W IDP1 hom Verified 1.2338169490762 0.108635561104911 no 546 0.184750216443297 666 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes isocitrate metabolic process|glutamate biosynthetic process isocitrate dehydrogenase (NADP+) activity mitochondrial nucleoid|mitochondrion
YNL191W YNL191W DUG3 hom Verified 1.23316566300059 0.108756981645379 no 547 0.0975561950419458 387 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Component of glutamine amidotransferase (GATase II); forms a complex with Dug2p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p) glutathione catabolic process peptidase activity|omega peptidase activity|gamma-glutamyltransferase activity|carbon-nitrogen ligase activity, with glutamine as amido-N-donor cytoplasm
YBR057C YBR057C MUM2 hom Verified 1.23231251170101 0.108916183919671 no 548 0.115402748055957 423 NA FT CELL CYCLE Cytoplasmic protein essential for meiotic DNA replication and sporulation; interacts with Orc2p, which is a component of the origin recognition complex premeiotic DNA replication molecular_function cytoplasm
YGR036C YGR036C CAX4 hom Verified 1.23193442543131 0.108986790245769 no 549 0.103485434075264 354 NA FT LIPID METABOLISM|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation lipid biosynthetic process|protein N-linked glycosylation dolichyldiphosphatase activity integral to endoplasmic reticulum membrane|integral to membrane
YJR075W YJR075W HOC1 hom Verified 1.2261105918161 0.110078530259758 no 550 0.0965060621106813 397 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM GOLGI APPARATUS Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele cell wall mannoprotein biosynthetic process|substituted mannan metabolic process alpha-1,6-mannosyltransferase activity|transferase activity, transferring glycosyl groups alpha-1,6-mannosyltransferase complex
YGR011W_d YGR011W YGR011W hom Dubious 1.22611058031232 0.110078532423986 no 551 0.0921565591542743 325 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR326C YDR326C YSP2 hom Verified 1.22525380182734 0.11023980443896 no 552 0.116560198937938 474 NA FT MITOCHONDRION Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification; YSP2 has a paralog, YHR080C, that arose from the whole genome duplication apoptotic process molecular_function mitochondrion
YPL220W YPL220W RPL1A hom Verified 1.22437634113401 0.11040514505134 no 553 0.0930832266920953 367 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L1A; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1A has a paralog, RPL1B, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YDR435C YDR435C PPM1 hom Verified 1.22374061986854 0.110525045535347 no 554 0.148822329570125 568 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS Carboxyl methyltransferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits cellular protein complex assembly|C-terminal protein methylation protein C-terminal leucine carboxyl O-methyltransferase activity cellular_component
YLR296W_d YLR296W YLR296W hom Dubious 1.22289742766855 0.110684220131983 no 555 0.109120735572216 417 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YMR063W YMR063W RIM9 hom Verified 1.22281905113524 0.110699024094649 no 556 0.167717274507099 625 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Plasma membrane protein of unknown function; involved in the proteolytic activation of Rim101p in response to alkaline pH; interacts with Rim21p and Dfg16p to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; has similarity to A. nidulans PalI; ascospore formation molecular_function integral to membrane
YDR143C YDR143C SAN1 hom Verified 1.22277001313388 0.110708287240987 no 557 0.107796798759626 346 NA FT PROTEOLYSIS NUCLEUS Ubiquitin-protein ligase; involved in the proteasome-dependent degradation of aberrant nuclear proteins; targets substrates with regions of exposed hydrophobicity containing 5 or more contiguous hydrophobic residues; contains intrinsically disordered regions that contribute to substrate recognition nucleus-associated proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to misfolded protein|response to stress ubiquitin-protein ligase activity nucleus|cytoplasm
YKL164C YKL164C PIR1 hom Verified 1.21969860657131 0.111289575013369 no 558 0.102898193710827 361 NA FT PROTEIN LOCALIZATION|CELL WALL ORG/BIOGENESIS O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle; PIR1 has a paralog, YJL160C, that arose from the whole genome duplication intracellular protein transport|fungal-type cell wall organization structural constituent of cell wall fungal-type cell wall
YLR231C YLR231C BNA5 hom Verified 1.2187433834941 0.111470803115358 no 559 0.0841538768597721 347 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM NUCLEUS Kynureninase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p de novo NAD biosynthetic process from tryptophan kynureninase activity nucleus|cytoplasm
YGR196C YGR196C FYV8 hom Verified 1.21842477795578 0.111531296963036 no 560 0.111369215006472 426 NA Protein of unknown function, required for survival upon exposure to K1 killer toxin biological_process molecular_function cytoplasm
YBR015C YBR015C MNN2 hom Verified 1.21796099151538 0.11161939838802 no 561 0.169772008580155 626 NA FF|FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment protein glycosylation alpha-1,2-mannosyltransferase activity Golgi apparatus
YJR124C_p YJR124C YJR124C hom Uncharacterized 1.21711741752843 0.111779772331675 no 562 0.0864552209443499 357 NA Putative protein of unknown function; expression induced under calcium shortage biological_process molecular_function integral to membrane
YLR281C_p YLR281C YLR281C hom Uncharacterized 1.21621323203924 0.111951852205787 no 563 0.0964411450039765 355 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION MITOCHONDRION Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR281C is not an essential gene biological_process molecular_function mitochondrion
YIL070C YIL070C MAM33 hom Verified 1.21592060998167 0.112007583061762 no 564 0.128781897958833 456 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Acidic protein of the mitochondrial matrix involved in oxidative phosphorylation; related to the human complement receptor gC1q-R aerobic respiration molecular_function mitochondrion|mitochondrial matrix
YJL038C YJL038C LOH1 hom Verified 1.2147723467055 0.112226465297105 no 565 0.114856757323265 442 NA Protein of unknown function with proposed roles in maintenance of genome integrity and also in spore wall assembly; induced during sporulation; repressed during vegetative growth by Sum1p and Hst1p; sequence similar to IRC1 chromosome organization molecular_function cellular_component
YHR018C YHR018C ARG4 hom Verified 1.21256755341639 0.112647600203801 no 566 0.102527848960976 367 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway arginine biosynthetic process via ornithine argininosuccinate lyase activity cytosol
YLR170C YLR170C APS1 hom Verified 1.21207219563852 0.112742372962982 no 567 0.127005509647003 461 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex Golgi to vacuole transport|vesicle-mediated transport clathrin binding AP-1 adaptor complex
YGL170C YGL170C SPO74 hom Verified 1.20989170300187 0.113160225684173 no 568 0.116535290244711 443 NA FT NUCLEUS|CYTOSKELETON Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation ascospore formation structural molecule activity spindle pole body
YGL126W YGL126W SCS3 hom Verified 1.2098714665787 0.113164108803768 no 569 0.121803671945839 447 NA FT LIPID METABOLISM ENDOPLASMIC RETICULUM Protein required for inositol prototrophy; required for normal ER membrane biosynthesis; ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; disputed role in the synthesis of inositol phospholipids from inositol phospholipid metabolic process molecular_function integral to membrane|endoplasmic reticulum
YER055C YER055C HIS1 hom Verified 1.20916465720117 0.113299796448373 no 570 0.114159085314931 420 NA FT KETONE METABOLISM|AMINO ACID METABOLISM ATP phosphoribosyltransferase, a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control histidine biosynthetic process ATP phosphoribosyltransferase activity cellular_component
YNR075W YNR075W COS10 hom Verified 1.20549782658271 0.114005588278332 no 571 0.0964339023242416 400 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins endocytosis molecular_function nuclear envelope|integral to membrane|endoplasmic reticulum|cytoplasm
YEL031W YEL031W SPF1 hom Verified 1.20425442170927 0.114245628624898 no 572 0.177623318546874 676 NA FF|FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS P-type ATPase, ion transporter of the ER membrane; required to maintain normal lipid composition of intracellular compartments and proper targeting of mitochondrial outer membrane tail-anchored proteins; involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1 cellular calcium ion homeostasis|transmembrane transport ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism mitochondrion|integral to membrane|endoplasmic reticulum membrane|cis-Golgi network
YLR423C YLR423C ATG17 hom Verified 1.20353642873977 0.114384401576545 no 573 0.1253169751004 502 NA FT MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION Scaffold protein responsible for phagophore assembly site organization; regulatory subunit of an autophagy-specific complex that includes Atg1p and Atg13p; stimulates Atg1p kinase activity; human ortholog RB1CC1/FIP200 interacts with p53, which inhibits autophagy in human cells piecemeal microautophagy of nucleus|mitochondrion degradation|peroxisome degradation|activation of protein kinase activity|autophagic vacuole assembly protein kinase activator activity|protein complex scaffold pre-autophagosomal structure|Atg1p signaling complex
YBL005W YBL005W PDR3 hom Verified 1.20307116558419 0.114474391223349 no 574 0.11181059496051 413 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Transcriptional activator of the pleiotropic drug resistance network; regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements); post-translationally up-regulated in cells lacking a functional mitochondrial genome; PDR3 has a paralog, PDR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress Unknown|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus|cytoplasm
YBL069W YBL069W AST1 hom Verified 1.20024533626363 0.115022036353141 no 575 0.101423354745551 399 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS GOLGI APPARATUS|PLASMA MEMBRANE Lipid raft associated protein; interacts with the plasma membrane ATPase Pma1p and has a role in its targeting to the plasma membrane by influencing its incorporation into lipid rafts; sometimes classified in the medium-chain dehydrogenase/reductases (MDRs) superfamily; AST1 has a paralog, AST2, that arose from the whole genome duplication protein targeting to membrane|protein transport into membrane raft molecular_function late endosome|membrane raft|Golgi apparatus|plasma membrane
YLR326W_p YLR326W YLR326W hom Uncharacterized 1.19887334609164 0.115288598613774 no 576 0.0934499731282621 299 NA Putative protein of unknown function, predicted to be palmitoylated biological_process molecular_function cellular_component
YKL115C_d YKL115C YKL115C hom Dubious 1.19741036932723 0.115573321981341 no 577 0.107841059068879 420 NA Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1 Unknown Unknown Unknown
YJL007C_d YJL007C YJL007C hom Dubious 1.19728645025571 0.115597461941455 no 578 0.109948264737794 392 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGL090W YGL090W LIF1 hom Verified 1.19642877448812 0.115764639010221 no 579 0.118186317750915 462 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein double-strand break repair via nonhomologous end joining chromatin binding DNA ligase IV complex|nuclear chromatin|nucleus
YDR458C YDR458C HEH2 hom Verified 1.19626443000262 0.115796692421603 no 580 0.122167721368322 461 NA FT ENDOMEMBRANE SYSTEM|NUCLEUS Inner nuclear membrane (INM) protein; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence; targeting to the INM requires the Srp1p-Kap95p karyopherins and the Ran cycle biological_process molecular_function nuclear envelope
YDR401W_d YDR401W YDR401W hom Dubious 1.19385200305823 0.116267932672506 no 581 0.126573358945713 425 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YJR088C YJR088C EMC2 hom Verified 1.19032873382017 0.116958605724408 no 582 0.0893641142952925 380 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-2, fly CG17556, human TTC35 protein folding in endoplasmic reticulum molecular_function ER membrane protein complex|endoplasmic reticulum
YKR017C YKR017C HEL1 hom Verified 1.18812465049901 0.117392151966513 no 583 0.120496190502618 465 NA RING finger ubiquitin ligase (E3); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU) biological_process molecular_function cellular_component
YDR270W YDR270W CCC2 hom Verified 1.18616970543705 0.117777643677819 no 584 0.147391706495049 568 NA FF|FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism cellular iron ion homeostasis|copper ion export|transmembrane transport copper ion binding|cation-transporting ATPase activity integral to membrane|trans-Golgi network transport vesicle membrane
YLR210W YLR210W CLB4 hom Verified 1.18612068341783 0.117787321731593 no 585 0.117092282742853 390 NA FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION NUCLEUS|CYTOSKELETON B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation G2/M transition of mitotic cell cycle|S phase of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|positive regulation of spindle pole body separation cyclin-dependent protein kinase regulator activity nucleus|spindle pole body|cytoplasm
YKR027W YKR027W BCH2 hom Verified 1.18584681272024 0.11784140034713 no 586 0.118728862920797 440 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM MITOCHONDRION|GOLGI APPARATUS Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; BCH2 has a paralog, CHS6, that arose from the whole genome duplication Golgi to plasma membrane transport|fungal-type cell wall chitin biosynthetic process molecular_function trans-Golgi network transport vesicle|mitochondrion|clathrin-coated vesicle|exomer complex
YDL075W YDL075W RPL31A hom Verified 1.18425120028015 0.118156819958602 no 587 0.150998033320216 535 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L31A; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31A has a paralog, RPL31B, that arose from the whole genome duplication cytoplasmic translation|regulation of translational fidelity structural constituent of ribosome cytosolic large ribosomal subunit
YIL039W YIL039W TED1 hom Verified 1.18374079009276 0.118257843432464 no 588 0.154562398523327 578 NA FT VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) ER to Golgi vesicle-mediated transport molecular_function endoplasmic reticulum
YLR090W YLR090W XDJ1 hom Verified 1.1825640336054 0.118490986868217 no 589 0.129689936178963 459 NA FT NUCLEUS|MITOCHONDRION Chaperone with a role in facilitating mitochondrial protein import; ascomycete-specific member of the DnaJ-like family, closely related to Ydj1p; predicted to be C-terminally prenylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies protein folding chaperone binding mitochondrion|integral to mitochondrial outer membrane|nucleus
YMR034C_p YMR034C YMR034C hom Uncharacterized 1.1818470213946 0.118633203204262 no 590 0.127772281231358 372 NA Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene biological_process sterol transporter activity integral to membrane
YKL213C YKL213C DOA1 hom Verified 1.17972930598078 0.119053947109851 no 591 0.110793019520943 438 NA FT RESPONSE TO DNA DAMAGE|PROTEOLYSIS NUCLEUS WD repeat protein required for ubiquitin-mediated protein degradation; forms a complex with Cdc48p; plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon DNA replication stress double-strand break repair via nonhomologous end joining|ubiquitin-dependent protein catabolic process ubiquitin binding nucleus|cytoplasm
YKR029C YKR029C SET3 hom Verified 1.17842210212037 0.119314185322466 no 592 0.124306161856541 467 NA FT CELL CYCLE|CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Defining member of the SET3 histone deacetylase complex which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains; SET3 has a paralog, SET4, that arose from the whole genome duplication negative regulation of meiosis|regulation of transcription, DNA-dependent|histone deacetylation methylated histone residue binding Rpd3L-Expanded complex|Set3 complex
YKL094W YKL094W YJU3 hom Verified 1.1777277807414 0.119452573985617 no 593 0.117072018918964 406 NA FT LIPID METABOLISM ENDOPLASMIC RETICULUM|MITOCHONDRION Monoglyceride lipase (MGL), functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family triglyceride metabolic process serine hydrolase activity|acylglycerol lipase activity mitochondrial outer membrane|lipid particle|plasma membrane|membrane|cytoplasm
YKL168C YKL168C KKQ8 hom Verified 1.17738391502268 0.119521153496152 no 594 0.102674931279035 365 NA FT PROTEIN PHOSPHORYLATION Putative serine/threonine protein kinase with unknown cellular role; KKQ8 has a paralog, HAL5, that arose from the whole genome duplication biological_process protein kinase activity cytoplasm
YLR324W YLR324W PEX30 hom Verified 1.17591205810322 0.119815009937242 no 595 0.152002324466921 536 NA FF|FT PEROXISOME ORGANIZATION Peroxisomal integral membrane protein, involved in negative regulation of peroxisome number; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p peroxisome organization molecular_function integral to membrane|peroxisome|integral to peroxisomal membrane
YIL025C_d YIL025C YIL025C hom Dubious 1.17450781082637 0.120095842602672 no 596 0.154953949995355 547 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGR008C YGR008C STF2 hom Verified 1.17435681841634 0.120126066877604 no 597 0.118235077061975 385 NA FT MITOCHONDRION Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress cellular response to desiccation molecular_function cytoplasm
YNR068C_p YNR068C YNR068C hom Uncharacterized 1.17374138964058 0.120249313208722 no 598 0.113638396423826 464 NA Putative protein of unknown function; exhibits homology to C-terminal end of Bul1p; expressed as a readthrough product of BSC5, the readthrough locus being termed BUL3; the BUL3 readthrough product is involved in ubiquitin-mediated sorting of plasma membrane proteins and interacts with WW domains of Rsp5p in vitro, but in a functionally different way than the non-readthrough form biological_process molecular_function cellular_component
YDR304C YDR304C CPR5 hom Verified 1.1729620836277 0.12040550553739 no 599 0.1107202067445 456 NA FT ENDOPLASMIC RETICULUM Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum, catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfolded proteins in the ER biological_process peptidyl-prolyl cis-trans isomerase activity endoplasmic reticulum|cytoplasm
YNR005C_d YNR005C YNR005C hom Dubious 1.17195901713421 0.120606755290955 no 600 0.143112034281653 533 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR267W_p YLR267W BOP2 hom Uncharacterized 1.16867608011113 0.121267081378514 no 601 0.0707123706409895 276 NA Protein of unknown function biological_process molecular_function cellular_component
YHL024W YHL024W RIM4 hom Verified 1.16833760890937 0.121335305375054 no 602 0.141657796686029 476 NA FT CELL CYCLE Putative RNA-binding protein required for the expression of early and middle sporulation genes meiosis|reciprocal meiotic recombination|sporulation resulting in formation of a cellular spore|premeiotic DNA replication RNA binding cytoplasm
YPR029C YPR029C APL4 hom Verified 1.16827867705838 0.121347186740177 no 603 0.107074435916379 399 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport Golgi to vacuole transport|vesicle-mediated transport clathrin binding AP-1 adaptor complex
YLR087C YLR087C CSF1 hom Verified 1.16682694784024 0.121640131015075 no 604 0.196478689190612 694 NA FF|FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies fermentation molecular_function mitochondrion
YPR028W YPR028W YOP1 hom Verified 1.16610907447501 0.121785174101488 no 605 0.122557131894242 481 NA FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Membrane protein that interacts with Yip1p to mediate membrane traffic; interacts with Sey1p to maintain ER morphology; overexpression leads to cell death and accumulation of internal cell membranes; mutants have reduced phosphatidylserine transfer between the ER and mitochondria; forms ER foci upon DNA replication stress vesicle-mediated transport|endoplasmic reticulum organization|endoplasmic reticulum inheritance|nuclear pore complex assembly protein binding integral to membrane|endoplasmic reticulum|endoplasmic reticulum tubular network
YJR025C YJR025C BNA1 hom Verified 1.16586212413907 0.121835097385439 no 606 0.119948094149858 468 NA FT OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM NUCLEUS 3-hydroxyanthranilic acid dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p de novo NAD biosynthetic process from tryptophan 3-hydroxyanthranilate 3,4-dioxygenase activity cytoplasm
YLR217W_d YLR217W YLR217W hom Dubious 1.16477900874197 0.122054228942694 no 607 0.129697196179234 431 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CPR6 Unknown Unknown Unknown
YGL226W YGL226W MTC3 hom Verified 1.16422829695855 0.122165752816825 no 608 0.109091409826699 442 NA FT MITOCHONDRION Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; mtc3 is synthetically sick with cdc13-1 biological_process molecular_function mitochondrion
YIR029W YIR029W DAL2 hom Verified 1.16338642472261 0.122336377439521 no 609 0.112097836974141 427 NA Allantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation allantoin catabolic process allantoicase activity cellular_component
YKL080W YKL080W VMA5 hom Verified 1.16229072119915 0.122558697183568 no 610 0.176504108851791 596 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane vacuolar acidification proton-transporting ATPase activity, rotational mechanism fungal-type vacuole membrane|vacuolar proton-transporting V-type ATPase, V1 domain|integral to membrane
YPL068C_p YPL068C YPL068C hom Uncharacterized 1.16204948869537 0.122607681638703 no 611 0.128881380021519 451 NA FT NUCLEUS Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and is induced in response to the DNA-damaging agent MMS biological_process molecular_function nucleus
YLR111W_d YLR111W YLR111W hom Dubious 1.1618873730957 0.122640608402257 no 612 0.14430746736647 627 NA FF Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YNL299W YNL299W TRF5 hom Verified 1.1618383603243 0.122650564445335 no 613 0.136792305177696 514 NA FT CELL CYCLE|RNA PROCESSING|CELL DIVISION NUCLEUS Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Pap2p nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent snRNA catabolic process|ncRNA polyadenylation|histone mRNA catabolic process|nuclear polyadenylation-dependent mRNA catabolic process|U4 snRNA 3'-end processing|polyadenylation-dependent snoRNA 3'-end processing|snoRNA polyadenylation polynucleotide adenylyltransferase activity nucleolus|TRAMP complex
YDR446W YDR446W ECM11 hom Verified 1.16067107512759 0.122887844524918 no 614 0.0827616299692329 328 NA FT CELL CYCLE|CELL WALL ORG/BIOGENESIS NUCLEUS Non-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure fungal-type cell wall organization|reciprocal meiotic recombination molecular_function nucleus
YOR369C YOR369C RPS12 hom Verified 1.16046628192085 0.122929507063139 no 615 0.120095433504962 454 NA FT TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S12, no bacterial homolog cytoplasmic translation structural constituent of ribosome cytosolic small ribosomal subunit
YHL044W_p YHL044W YHL044W hom Uncharacterized 1.15925752224137 0.123175615373842 no 616 0.106132040604805 445 NA FT PLASMA MEMBRANE Putative integral membrane protein, member of DUP240 gene family; green fluorescent protein (GFP)-fusion protein localizes to the plasma membrane in a punctate pattern biological_process molecular_function plasma membrane
YLR376C YLR376C PSY3 hom Verified 1.15887645191939 0.123253274359183 no 617 0.120952830553306 487 NA FT RESPONSE TO DNA DAMAGE NUCLEUS Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function; structural analysis reveals a similar DNA-binding region in both Psy3p and Csm2p and that both regions work together to form a single DNA binding site; deletion of PSY3 results in a mutator phenotype; deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C recombinational repair|error-free translesion synthesis molecular_function nucleus|Shu complex|cytoplasm
YBR106W YBR106W PHO88 hom Verified 1.15852139834479 0.123325662215978 no 618 0.200400735792788 730 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations phosphate ion transport molecular_function mitochondrion|membrane
YHR115C YHR115C DMA1 hom Verified 1.15851231625001 0.123327514252175 no 619 0.132480186731923 522 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION Ubiquitin-protein ligase (E3); controls septin dynamics and the spindle position checkpoint (SPOC) along with functionally redundant ligase Dma2p by regulating the recruitment of Elm1p to the bud neck; regulates levels of the translation initiation factor eIF2 subunit Gcd11p, as well as abundance, localization, and ubiquitination of Cdk inhibitory kinase Swe1p; ubiquitinates cyclin Pcl1p; ortholog of human RNF8 protein, similar to human Chfr; contains FHA and RING finger establishment of mitotic spindle orientation|protein autoubiquitination|septin ring assembly|mitotic cell cycle spindle assembly checkpoint ubiquitin-protein ligase activity cytoplasm
YMR209C_p YMR209C YMR209C hom Uncharacterized 1.15791652105207 0.123449052393325 no 620 0.124086279902869 462 NA Putative S-adenosylmethionine-dependent methyltransferase; YMR209C is not an essential gene biological_process S-adenosylmethionine-dependent methyltransferase activity cellular_component
YKL215C YKL215C OXP1 hom Verified 1.15776397171609 0.123480184900107 no 621 0.0994623112323018 323 NA FT KETONE METABOLISM|AMINO ACID METABOLISM 5-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress glutathione metabolic process 5-oxoprolinase (ATP-hydrolyzing) activity cytoplasm
YDR121W YDR121W DPB4 hom Verified 1.1577061917344 0.123491978164865 no 622 0.142210120921023 479 NA FT GENE SILENCING NUCLEUS|CHROMOSOME Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization DNA-dependent DNA replication|chromatin silencing at telomere double-stranded DNA binding|single-stranded DNA binding|DNA-directed DNA polymerase activity chromatin accessibility complex|epsilon DNA polymerase complex
YDR520C_p YDR520C URC2 hom Uncharacterized 1.15744777260308 0.123544732821172 no 623 0.156635629501818 477 NA FT TRANSCRIPTION FROM RNA POL II|NUCLEOTIDE METABOLISM NUCLEUS Putative Zn(II)2Cys6 motif containing transcription factor; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; similar to S. kluyveri Urc2p involved in uracil catabolism uracil catabolic process sequence-specific DNA binding nucleus|cytoplasm
YPL096C-A YPL096C-A ERI1 hom Verified 1.15690719767625 0.123655138862815 no 624 0.159425168228784 593 NA FT LIPID METABOLISM|SIGNALING ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Endoplasmic reticulum membrane protein that binds to and inhibits GTP-bound Ras2p at the ER; component of the GPI-GnT complex which catalyzes the first step in GPI-anchor biosynthesis; probable homolog of mammalian PIG-Y protein GPI anchor biosynthetic process|Ras protein signal transduction GTPase inhibitor activity glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|endoplasmic reticulum membrane
YBR093C YBR093C PHO5 hom Verified 1.1557047702948 0.123900968148231 no 625 0.112006658638852 438 NA FT RESPONSE TO NUTRIENT LEVELS Repressible acid phosphatase (1 of 3) that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2 cellular response to phosphate starvation|phosphate-containing compound metabolic process|regulation of cell size nucleoside-triphosphate diphosphatase activity|nucleoside-triphosphatase activity|acid phosphatase activity fungal-type cell wall|cell wall-bounded periplasmic space
YKR031C YKR031C SPO14 hom Verified 1.15501530559212 0.12404207939565 no 626 0.118538645425353 448 NA FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|LIPID METABOLISM NUCLEUS Phospholipase D; catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions phospholipid metabolic process|exocytosis|cell morphogenesis involved in conjugation with cellular fusion|ascospore-type prospore assembly phospholipase D activity|phosphatidylinositol-3-phosphate binding endosome|nucleus|prospore membrane
YGR040W YGR040W KSS1 hom Verified 1.15442011217531 0.12416398675432 no 627 0.11354527555349 434 NA FT CELL CYCLE|SIGNALING|PROTEIN PHOSPHORYLATION NUCLEUS Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains pheromone-dependent signal transduction involved in conjugation with cellular fusion|signal transduction involved in filamentous growth|negative regulation of sequence-specific DNA binding transcription factor activity|protein phosphorylation|invasive growth in response to glucose limitation MAP kinase activity|protein kinase activity|transcription factor binding nucleus
YGL176C_p YGL176C YGL176C hom Uncharacterized 1.15376631369411 0.124297994160964 no 628 0.134652614293751 465 NA Putative protein of unknown function; deletion mutant is viable and has no detectable phenotype biological_process molecular_function cellular_component
YJR113C YJR113C RSM7 hom Verified 1.15299764198334 0.124455676178172 no 629 0.151997241244608 540 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S7 ribosomal protein mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YOR175C YOR175C ALE1 hom Verified 1.15234749512768 0.124589153650446 no 630 0.12870486337412 478 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Broad-specificity lysophospholipid acyltransferase, part of MBOAT family of membrane-bound O-acyltransferases; key component of Lands cycle; may have role in fatty acid exchange at sn-2 position of mature glycerophospholipids glycerophospholipid biosynthetic process 1-acylglycerophosphocholine O-acyltransferase activity|O-acyltransferase activity|1-acylglycerol-3-phosphate O-acyltransferase activity integral to membrane|ribosome|endoplasmic reticulum
YDR155C YDR155C CPR1 hom Verified 1.15145002664605 0.124773571499526 no 631 0.117143564755697 490 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CHROMATIN ORGANIZATION NUCLEUS|MITOCHONDRION|CHROMOSOME Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A; protein abundance increases in response to DNA replication stress cellular protein metabolic process|ascospore formation|positive regulation of meiosis|histone deacetylation peptidyl-prolyl cis-trans isomerase activity|cyclosporin A binding histone deacetylase complex|mitochondrion|Set3 complex|nucleus
YBR018C YBR018C GAL7 hom Verified 1.15090823812751 0.124884994136518 no 632 0.118911182621135 466 NA FT CARBOHYDRATE METABOLISM Galactose-1-phosphate uridyl transferase, synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism galactose catabolic process via UDP-galactose UDP-glucose:hexose-1-phosphate uridylyltransferase activity cytoplasm
YMR145C YMR145C NDE1 hom Verified 1.15034580142274 0.125000736741682 no 633 0.121707098883861 382 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Mitochondrial external NADH dehydrogenase, a type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain glucose catabolic process to ethanol|NADH oxidation|chronological cell aging NADH dehydrogenase activity mitochondrion
YCL009C YCL009C ILV6 hom Verified 1.14967659806891 0.125138548209222 no 634 0.116794603504815 430 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Regulatory subunit of acetolactate synthase, which catalyzes the first step of branched-chain amino acid biosynthesis; enhances activity of the Ilv2p catalytic subunit, localizes to mitochondria branched-chain amino acid biosynthetic process enzyme regulator activity|acetolactate synthase activity mitochondrial nucleoid|acetolactate synthase complex|mitochondrion
YMR031W-A_d YMR031W-A YMR031W-A hom Dubious 1.14930212668088 0.125215710738808 no 635 0.1232525617117 454 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C Unknown Unknown Unknown
YGR176W_d YGR176W YGR176W hom Dubious 1.14846194229652 0.125388957663039 no 636 0.104249940277519 385 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YHR156C YHR156C LIN1 hom Verified 1.14744247422786 0.125599397670701 no 637 0.127431430343548 477 NA FT NUCLEUS|CHROMOSOME Non-essential component of U5 snRNP; nuclear protein; physically interacts with Irr1p of cohesin complex; may link together proteins involved in chromosome segregation, mRNA splicing and DNA replication biological_process protein binding chromatin|nucleus|U4/U6 x U5 tri-snRNP complex|U5 snRNP
YER181C_d YER181C YER181C hom Dubious 1.14635826089668 0.125823472760569 no 638 0.118431781762733 449 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative data; extensively overlaps a Ty1 LTR; protein product is detected in highly purified mitochondria in high-throughput studies Unknown Unknown Unknown
YMR306W YMR306W FKS3 hom Verified 1.14630318055145 0.125834863689692 no 639 0.139151596655678 529 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM MITOCHONDRION|PLASMA MEMBRANE Protein involved in spore wall assembly, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies ascospore wall assembly 1,3-beta-D-glucan synthase activity mitochondrion|integral to membrane
YKL127W YKL127W PGM1 hom Verified 1.1456789858352 0.125964000973683 no 640 0.0948793418622698 362 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism glucose 6-phosphate metabolic process|galactose catabolic process|glucose 1-phosphate metabolic process|UDP-glucose metabolic process|trehalose biosynthetic process|glycogen biosynthetic process phosphoglucomutase activity cytoplasm
YHR112C YHR112C YHR112C hom Verified 1.14078181793197 0.126980364367958 no 641 0.116450360472782 434 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Protein of unknown function; localizes to the cytoplasm and nucleus; overexpression affects protein trafficking through the endocytic pathway sulfur compound metabolic process cystathionine beta-lyase activity nucleus|cytoplasm
YBR182C-A_p YBR182C-A YBR182C-A hom Uncharacterized 1.13978540754157 0.127187857311435 no 642 0.136803230982442 509 NA Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YDL188C YDL188C PPH22 hom Verified 1.13957314649027 0.127232089108955 no 643 0.126592415166058 432 NA FT CELL CYCLE|TRANSLATION|CELL DIVISION|CYTOSKELETON ORGANIZATION NUCLEUS|CHROMOSOME Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; PPH22 has a paralog, PPH21, that arose from the whole genome duplication actin filament organization|budding cell bud growth|G1/S transition of mitotic cell cycle|protein dephosphorylation|mitotic cell cycle spindle assembly checkpoint|regulation of translation protein serine/threonine phosphatase activity condensed nuclear chromosome, centromeric region
YPL073C_d YPL073C YPL073C hom Dubious 1.13914624689567 0.127321080537264 no 644 0.108134578879314 399 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps with verified gene UBP16/YPL072W; may interact with ribosome based on co-purification experiments Unknown Unknown Unknown
YGL149W_d YGL149W YGL149W hom Dubious 1.13374451094787 0.128450866436751 no 645 0.118943223723742 418 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF INO80/YGL150C. Unknown Unknown Unknown
YGR263C YGR263C SAY1 hom Verified 1.13361160709542 0.128478751033517 no 646 0.136687756123774 458 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Sterol deacetylase; component of the sterol acetylation/deacetylation cycle along with Atf2p; integral membrane protein with active site in the ER lumen; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum response to toxin|sterol metabolic process|sterol deacetylation steryl deacetylase activity integral to membrane|endoplasmic reticulum|endoplasmic reticulum lumen
YFL054C_p YFL054C YFL054C hom Uncharacterized 1.13107540079494 0.129011678483199 no 647 0.119528860189582 419 NA Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol water transport|transmembrane transport water channel activity|glycerol transmembrane transporter activity|transporter activity integral to membrane
YKR013W YKR013W PRY2 hom Verified 1.13046381530049 0.129140418664422 no 648 0.158379916476208 564 NA Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY1; may be involved in detoxification of hydrophobic compounds; PRY2 has a paralog, PRY1, that arose from the whole genome duplication biological_process molecular_function extracellular region|fungal-type vacuole
YLR311C_d YLR311C YLR311C hom Dubious 1.12854599229703 0.129544702346363 no 649 0.135421458585766 489 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YHR079C-A YHR079C-A SAE3 hom Verified 1.12510431411317 0.130272416709248 no 650 0.140939401178316 459 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Mei5p; proposed to be an assembly factor for Dmc1p double-strand break repair|reciprocal meiotic recombination|meiotic DNA recombinase assembly molecular_function condensed nuclear chromosome
YMR096W YMR096W SNZ1 hom Verified 1.12365241974242 0.130580254373318 no 651 0.101199341211207 349 NA FT COFACTOR METABOLISM Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins pyridoxine metabolic process|thiamine biosynthetic process protein binding cellular_component
YJL205C YJL205C NCE101 hom Verified 1.12339321713617 0.130635264633971 no 652 0.113996600812638 441 NA FT PROTEIN LOCALIZATION Protein of unknown function, involved in secretion of proteins that lack classical secretory signal sequences protein secretion molecular_function cellular_component
YPL049C YPL049C DIG1 hom Verified 1.12248795226663 0.130827513608001 no 653 0.155515385272281 573 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p negative regulation of transcription from RNA polymerase II promoter by pheromones|Unknown DNA binding|transcription factor binding nucleus
YLL030C_d YLL030C RRT7 hom Dubious 1.12153087947594 0.131030977460868 no 654 0.115388728808168 445 NA Identified in a screen for mutants with increased levels of rDNA transcription; dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDL241W_p YDL241W YDL241W hom Uncharacterized 1.12115144514553 0.131111701790047 no 655 0.114205525332253 397 NA Putative protein of unknown function; YDL241W is not an essential gene biological_process molecular_function cellular_component
YKL163W YKL163W PIR3 hom Verified 1.118412047205 0.13169552569933 no 656 0.114014147705654 420 NA FT CELL WALL ORG/BIOGENESIS O-glycosylated covalently-bound cell wall protein; required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway; PIR3 has a paralog, HSP150, that arose from the whole genome duplication fungal-type cell wall organization structural constituent of cell wall fungal-type cell wall
YKR050W YKR050W TRK2 hom Verified 1.11688847340075 0.1320210068268 no 657 0.144848839177779 463 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Component of the Trk1p-Trk2p potassium transport system; TRK2 has a paralog, TRK1, that arose from the whole genome duplication cellular potassium ion homeostasis potassium ion transmembrane transporter activity integral to membrane|plasma membrane
YGR034W YGR034W RPL26B hom Verified 1.11592079282693 0.132228020298347 no 658 0.152401503785341 522 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L26B; binds to 5.8S rRNA; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26B has a paralog, RPL26A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YDR206W YDR206W EBS1 hom Verified 1.11107960327603 0.133267043269761 no 659 0.139507557546761 390 NA FT TRANSLATION NUCLEUS|CHROMOSOME Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors negative regulation of translation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay molecular_function cytoplasmic mRNA processing body|cytoplasm
YCR081W YCR081W SRB8 hom Verified 1.10952765435525 0.133601310647344 no 660 0.149918309064021 549 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS NUCLEUS Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in glucose repression negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription by galactose|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription coactivator activity mediator complex
YNL335W_p YNL335W DDI3 hom Uncharacterized 1.10915687834965 0.13368125569209 no 661 0.134372984463689 498 NA Protein of unknown function; expression is induced over 100-fold by DNA damage; induction decreased in rad6 and rad18 mutants biological_process molecular_function cellular_component
YIL002C YIL002C INP51 hom Verified 1.10783873055539 0.133965735033184 no 662 0.16906403154775 595 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION CYTOSKELETON Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in phosphatidylinositol 4,5-bisphosphate homeostasis and in endocytosis; null mutation confers cold-tolerant growth phosphatidylinositol dephosphorylation phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity membrane|cytoplasm
YHR041C YHR041C SRB2 hom Verified 1.10510975293981 0.134556017530204 no 663 0.181234312508508 595 NA FT TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|RESPONSE TO NUTRIENT LEVELS NUCLEUS RNA POL II, HOLOENZYME Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to chemical stimulus|RNA polymerase II transcriptional preinitiation complex assembly|negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to nutrient levels|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly|core RNA polymerase II binding transcription factor activity|RNA polymerase II transcription factor recruiting transcription factor activity|TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly|protein domain specific binding core mediator complex
YJR008W YJR008W MHO1 hom Verified 1.10473706878287 0.134636768089862 no 664 0.126420508173972 456 NA FT NUCLEUS Protein of unknown function; inhibits haploid invasive growth when overexpressed; synthetically lethal with phospholipase C (PLC1); expression induced by mild heat-stress on a non-fermentable carbon source, upon entry into stationary phase and upon nitrogen deprivation; repressed by inosine and choline in an Opi1p-dependent manner; highly conserved from bacteria to human; Memo, the human homolog, is an ErbB2 interacting protein with an essential function in cell motility biological_process molecular_function nucleus|cytoplasm
YJR099W YJR099W YUH1 hom Verified 1.10423335634465 0.13474596177387 no 665 0.11460061807355 389 NA FT PROTEOLYSIS Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p protein deubiquitination ubiquitin-specific protease activity cytoplasm
YIL134C-A_p YIL134C-A YIL134C-A hom Uncharacterized 1.10023642025647 0.135614562975925 no 666 0.126307393111604 479 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YER180C-A YER180C-A SLO1 hom Verified 1.09908908700986 0.135864604751181 no 667 0.15399416287322 595 NA FT PROTEIN LOCALIZATION Protein interacting with Arl3p, which is a GTPase of the Ras superfamily involved in vesicle-tethering at the Golgi; putative ortholog of human SCOCO intracellular protein transport small GTPase regulator activity cytoplasm
YOL150C_d YOL150C YOL150C hom Dubious 1.09843944760516 0.136006322509165 no 668 0.123512308833974 432 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLL047W_d YLL047W YLL047W hom Dubious 1.0973792788299 0.1362378138314 no 669 0.148437473601887 521 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RNP1 Unknown Unknown Unknown
YKL214C YKL214C YRA2 hom Verified 1.09716086292941 0.13628553913393 no 670 0.112013820067048 431 NA FT RNA LOCALIZATION NUCLEUS Member of the REF (RNA and export factor binding proteins) family; when overexpressed, can substitute for the function of Yra1p in export of poly(A)+ mRNA from the nucleus poly(A)+ mRNA export from nucleus RNA binding nucleus
YDR153C YDR153C ENT5 hom Verified 1.09351017533065 0.137084931934382 no 671 0.119111447779195 385 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin late endosome to vacuole transport via multivesicular body sorting pathway|early endosome to Golgi transport|Golgi to endosome transport clathrin binding|phosphatidylinositol-3,5-bisphosphate binding endosome|clathrin vesicle coat|cytoplasm
YGR271W YGR271W SLH1 hom Verified 1.09122959037388 0.137585935279141 no 672 0.137870013575218 495 NA FT TRANSLATION RIBOSOME Putative RNA helicase related to Ski2p, involved in translation inhibition of non-poly(A) mRNAs; required for repressing propagation of dsRNA viruses cytoplasmic translation|regulation of translation RNA helicase activity polysomal ribosome|cytoplasm
YPL170W YPL170W DAP1 hom Verified 1.08923712176319 0.138024666410964 no 673 0.163130624311483 605 NA FT LIPID METABOLISM Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis regulation of ergosterol biosynthetic process heme binding endosome|membrane
YBR035C YBR035C PDX3 hom Verified 1.08897022188012 0.138083508752015 no 674 0.129488464865914 527 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism fatty acid metabolic process pyridoxamine-phosphate oxidase activity cellular_component
YKL064W YKL064W MNR2 hom Verified 1.08324717113013 0.139349363612193 no 675 0.130611588995235 461 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Vacuolar membrane protein required for magnesium homeostasis; putative magnesium transporter; has similarity to Alr1p and Alr2p, which mediate influx of Mg2+ and other divalent cations cellular magnesium ion homeostasis magnesium ion transmembrane transporter activity fungal-type vacuole membrane|integral to membrane
YFR030W YFR030W MET10 hom Verified 1.08294187508132 0.139417111721479 no 676 0.140336675237776 509 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY Subunit alpha of assimilatory sulfite reductase, which converts sulfite into sulfide sulfate assimilation sulfite reductase (NADPH) activity sulfite reductase complex (NADPH)
YOL023W YOL023W IFM1 hom Verified 1.08288030160291 0.139430778179167 no 677 0.166120525267961 608 NA FT TRANSLATION|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial translation initiation factor 2 translational initiation|mitochondrial translational initiation|mitochondrial translation tRNA binding|GTPase activity|translation initiation factor activity mitochondrion
YIR019C YIR019C FLO11 hom Verified 1.08251261550352 0.139512406415895 no 678 0.119892394587039 467 NA FT SITE OF POLARIZED GROWTH|PLASMA MEMBRANE GPI-anchored cell surface glycoprotein (flocculin); required for pseudohyphal formation, invasive growth, flocculation, and biofilms; transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p); required for the formation of fibrous interconnections between cells in a colony of a wild S. cerevisiae strain cell-cell adhesion|biofilm formation|pseudohyphal growth|filamentous growth|flocculation|invasive growth in response to glucose limitation molecular_function extracellular region|plasma membrane|cellular bud neck
YGL221C YGL221C NIF3 hom Verified 1.08191445803446 0.139645269937131 no 679 0.129808328975179 467 NA FT MITOCHONDRION Protein of unknown function, similar to Listeria monocytogenes major sigma factor (rpoD gene product); the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion|cytoplasm
YKL102C_d YKL102C YKL102C hom Dubious 1.08102840981407 0.139842238200298 no 680 0.12888669718101 442 NA Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site Unknown Unknown Unknown
YPL023C YPL023C MET12 hom Verified 1.0802076124087 0.140024869641921 no 681 0.146901911966946 522 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS Protein with methylenetetrahydrofolate reductase (MTHFR) activity in vitro; null mutant has no phenotype and is prototrophic for methionine; MET13 encodes major isozyme of MTHFR biological_process methylenetetrahydrofolate reductase (NADPH) activity cellular_component
YER144C YER144C UBP5 hom Verified 1.07992398543902 0.140088015691462 no 682 0.138347455107843 512 NA FT PROTEOLYSIS SITE OF POLARIZED GROWTH Putative ubiquitin-specific protease, closest paralog of Doa4p but has no functional overlap; concentrates at the bud neck protein deubiquitination ubiquitin-specific protease activity incipient cellular bud site|cellular bud neck
YOR054C YOR054C VHS3 hom Verified 1.07972317415949 0.140132735544587 no 683 0.150301397301945 505 NA FT CELL CYCLE|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|COFACTOR METABOLISM Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis coenzyme A biosynthetic process|cellular monovalent inorganic cation homeostasis phosphopantothenoylcysteine decarboxylase activity|protein phosphatase inhibitor activity phosphopantothenoylcysteine decarboxylase complex
YBR064W_d YBR064W YBR064W hom Dubious 1.07888548659546 0.140319389752312 no 684 0.122449028456851 445 NA Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YBR063C Unknown Unknown Unknown
YOL024W_p YOL024W YOL024W hom Uncharacterized 1.07823178412728 0.14046516549197 no 685 0.128494201793574 456 NA Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site; YOL024W has a paralog, IGD1, that arose from the whole genome duplication biological_process molecular_function cellular_component
YOR163W YOR163W DDP1 hom Verified 1.07806307272672 0.140502804843804 no 686 0.122170196793313 436 NA FT CARBOHYDRATE METABOLISM NUCLEUS Polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; high specificity for diadenosine hexa- and pentaphosphates; contains endopolyphosphatase activity with a high affinity for polyphosphates, an activity also observed for its human DIPP homologs; possesses mRNA decapping activity; nudix hydrolase family member; protein abundance increases in response to DNA replication stress polyphosphate catabolic process|inositol phosphate dephosphorylation|diadenosine polyphosphate catabolic process diphosphoinositol-polyphosphate diphosphatase activity|endopolyphosphatase activity|bis(5'-adenosyl)-pentaphosphatase activity|bis(5'-adenosyl)-hexaphosphatase activity nucleus|cytoplasm
YBR285W_p YBR285W YBR285W hom Uncharacterized 1.07740064046209 0.140650659065967 no 687 0.163129636342816 546 NA Putative protein of unknown function; YBR285W is not an essential gene biological_process molecular_function cellular_component
YJL077W-B_p YJL077W-B YJL077W-B hom Uncharacterized 1.07683826608169 0.140776263316591 no 688 0.183863624121183 581 NA Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YGR081C YGR081C SLX9 hom Verified 1.07680837381373 0.140782941774345 no 689 0.160401293045655 583 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Protein required for pre-rRNA processing; associated with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function preribosome, small subunit precursor|nucleolus|nucleus|90S preribosome
YKL202W_d YKL202W YKL202W hom Dubious 1.07550018325095 0.141075425104485 no 690 0.109235812441575 367 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPR170C_d YPR170C YPR170C hom Dubious 1.07315194973066 0.141601472800063 no 691 0.194801985024469 607 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORFs YPR169W-A and YPR170W-B Unknown Unknown Unknown
YOL103W YOL103W ITR2 hom Verified 1.07250447170048 0.141746753269681 no 692 0.143921072878028 494 NA FT PLASMA MEMBRANE Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively myo-inositol transport myo-inositol transmembrane transporter activity integral to membrane|plasma membrane|membrane
YMR026C YMR026C PEX12 hom Verified 1.07232791553595 0.141786386275808 no 693 0.163522153250905 523 NA FT PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION C3HC4-type RING-finger peroxin and E3 ubiquitin ligase, required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder protein import into peroxisome matrix ubiquitin-protein ligase activity|protein binding integral to peroxisomal membrane
YCL011C YCL011C GBP2 hom Verified 1.07173369862527 0.141919830135872 no 694 0.164888792348647 562 NA FT RNA LOCALIZATION NUCLEUS|CHROMOSOME Poly(A+) RNA-binding protein; involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Npl3p; also binds single-stranded telomeric repeat sequence in vitro; GBP2 has a paralog, HRB1, that arose from the whole genome duplication poly(A)+ mRNA export from nucleus|telomere maintenance RNA binding|telomeric DNA binding nucleus|cytoplasmic stress granule
YPL221W YPL221W FLC1 hom Verified 1.07136034008468 0.142003719107071 no 695 0.133813876032996 495 NA FT CELL WALL ORG/BIOGENESIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance protein folding|fungal-type cell wall biogenesis|FAD transport FAD transmembrane transporter activity integral to membrane|endoplasmic reticulum|fungal-type vacuole|cellular bud neck
YEL059C-A YEL059C-A SOM1 hom Verified 1.07049701220727 0.142197826563156 no 696 0.128255658346596 473 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs proteolysis|mitochondrial respiratory chain complex assembly endopeptidase activity mitochondrial inner membrane peptidase complex|mitochondrial inner membrane
YKR103W YKR103W NFT1 hom Verified 1.06998570743837 0.142312871063531 no 697 0.141661569832795 521 NA FT NUCLEOTIDE METABOLISM Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds. transport ATPase activity, coupled to transmembrane movement of substances integral to membrane|membrane
YOR015W_d YOR015W YOR015W hom Dubious 1.06910366157627 0.142511480965235 no 698 0.130624387898815 485 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR055W YDR055W PST1 hom Verified 1.06877478274464 0.142585582432043 no 699 0.142133418071039 459 NA FT CELL WALL ORG/BIOGENESIS PLASMA MEMBRANE Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1 fungal-type cell wall organization molecular_function fungal-type cell wall|plasma membrane
YER005W YER005W YND1 hom Verified 1.06558948828659 0.143304626528115 no 700 0.142388705073801 525 NA FT LIPID METABOLISM|CARBOHYDRATE METABOLISM GOLGI APPARATUS Apyrase with wide substrate specificity, helps prevent inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates that inhibit glycotransferases; partially redundant with Gda1p; mediates adenovirus E4orf4-induced toxicity protein glycosylation nucleoside-triphosphatase activity|nucleoside-diphosphatase activity COPI-coated vesicle|Golgi apparatus|membrane|Golgi membrane
YLR451W YLR451W LEU3 hom Verified 1.06290922664944 0.143911559192813 no 701 0.140429035945373 468 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Zinc-knuckle transcription factor, repressor and activator; regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; acts as a repressor in leucine-replete conditions and as an activator in the presence of alpha-isopropylmalate, an intermediate in leucine biosynthesis that accumulates during leucine starvation negative regulation of transcription from RNA polymerase II promoter|Unknown|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YCR088W YCR088W ABP1 hom Verified 1.06260018541592 0.143981651454234 no 702 0.129351179589921 450 NA FT PROTEIN LOCALIZATION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization; phosphorylation within its PRR (Proline-Rich Region), mediated by Cdc28p and Pho85p, protects Abp1p from proteolysis mediated by its own PEST sequences protein localization|actin cortical patch assembly actin filament binding cell cortex|mating projection tip|cytoplasm|actin cortical patch
YGR139W_d YGR139W YGR139W hom Dubious 1.06144932226887 0.144242876083954 no 703 0.113304011570555 414 NA Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YJL134W YJL134W LCB3 hom Verified 1.0604112517258 0.144478772774552 no 704 0.141354594379955 479 NA FT LIPID METABOLISM|SIGNALING ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Long-chain base-1-phosphate phosphatase; specific for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids; LCB3 has a paralog, YSR3, that arose from the whole genome duplication calcium-mediated signaling|sphingolipid biosynthetic process sphingosine-1-phosphate phosphatase activity integral to membrane|endoplasmic reticulum
YDR533C YDR533C HSP31 hom Verified 1.05739303911892 0.145166123527372 no 705 0.17326054587642 618 NA FT PROTEOLYSIS Possible chaperone and cysteine protease; has similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site; protein abundance increases in response to DNA replication stress biological_process unfolded protein binding|cysteine-type peptidase activity cellular_component
YLR219W YLR219W MSC3 hom Verified 1.05622833238589 0.145431954765322 no 706 0.111039970361085 416 NA FT CELL CYCLE PLASMA MEMBRANE Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; msc3 mutants are defective in directing meiotic recombination events to homologous chromatids; potential Cdc28p substrate; protein abundance increases in response to DNA replication stress reciprocal meiotic recombination molecular_function cellular_component
YHL031C YHL031C GOS1 hom Verified 1.05358818262504 0.146035750954476 no 707 0.227649381277043 807 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|GOLGI APPARATUS v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28 Golgi vesicle transport|vesicle fusion SNAP receptor activity SNARE complex|integral to membrane|Golgi medial cisterna
YGL181W YGL181W GTS1 hom Verified 1.05144539019398 0.146527039107971 no 708 0.149982708138575 479 NA FT VESICLE-MEDIATED TRANSPORT|TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM|MEMBRANE ORGANIZATION|SIGNALING|NUCLEOTIDE METABOLISM NUCLEUS|CYTOSKELETON Protein involved in Arf3p regulation and in transcription regulation; localizes to the nucleus and to endocytic patches; contains an N-terminal Zn-finger and ArfGAP homology domain, a C-terminal glutamine-rich region, and a UBA (ubiquitin associated) domain; gts1 mutations affect budding, cell size, heat tolerance, sporulation, life span, ultradian rhythms, endocytosis; expression oscillates in a pattern similar to metabolic oscillations endocytosis|ultradian rhythm|regulation of transcription from RNA polymerase II promoter|negative regulation of phosphatidylinositol biosynthetic process|positive regulation of transcription from RNA polymerase II promoter ARF GTPase activator activity|repressing transcription factor binding|transcription factor binding transcription factor activity nucleus|cytoplasm|actin cortical patch
YNL176C_p YNL176C TDA7 hom Uncharacterized 1.05073328591893 0.146690551932562 no 709 0.14609240159439 478 NA Cell cycle-regulated gene of unknown function, promoter bound by Fkh2p; null mutant is sensitive to expression of the top1-T722A allele biological_process molecular_function fungal-type vacuole
YHR111W YHR111W UBA4 hom Verified 1.04757056244047 0.14741825305983 no 710 0.158126407075356 577 NA FT RNA PROCESSING|CELL DIVISION|RESPONSE TO OXIDATIVE STRESS Protein that activates Urm1p before its conjugation to proteins (urmylation); also acts in thiolation of the wobble base of cytoplasmic tRNAs by adenylating and then thiolating Urm1p; receives sulfur from Tum1p cellular response to oxidative stress|tRNA wobble position uridine thiolation|cell budding|protein urmylation|tRNA thio-modification|Unknown|invasive growth in response to glucose limitation URM1 activating enzyme activity|sulfurtransferase activity|thiosulfate sulfurtransferase activity|protein adenylyltransferase activity cytoplasm
YDR095C_d YDR095C YDR095C hom Dubious 1.04712306377921 0.147521411632027 no 711 0.151924426984306 472 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YNL012W YNL012W SPO1 hom Verified 1.04604752780407 0.147769544777385 no 712 0.125610800629721 465 NA FT CELL CYCLE|LIPID METABOLISM|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Meiosis-specific prospore protein; required for meiotic spindle pole body duplication and separation; required to produce bending force necessary for proper prospore membrane assembly during sporulation; has similarity to phospholipase B meiosis|spore membrane bending pathway phospholipase activity endoplasmic reticulum|nucleus|prospore membrane
YML078W YML078W CPR3 hom Verified 1.04484181417797 0.148048042834707 no 713 0.156415295206754 574 NA FT MITOCHONDRION Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; involved in protein refolding after import into mitochondria protein folding|apoptotic process peptidyl-prolyl cis-trans isomerase activity mitochondrion
YGR097W YGR097W ASK10 hom Verified 1.04270292210657 0.148542952056732 no 714 0.14941213388981 494 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO OXIDATIVE STRESS NUCLEUS RNA POL II, HOLOENZYME Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication cellular protein catabolic process|cellular response to oxidative stress|positive regulation of transcription from RNA polymerase II promoter|positive regulation of glycerol transport molecular_function DNA-directed RNA polymerase II, holoenzyme|cytoplasm
YER143W YER143W DDI1 hom Verified 1.04215627984158 0.148669614589228 no 715 0.121390803131722 458 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS PLASMA MEMBRANE DNA damage-inducible v-SNARE binding protein with a role in suppression of protein secretion; may play a role in S-phase checkpoint control; has ubiquitin-associated (UBA), ubiquitin-like (UBL), and retroviral-like proteinase (RVP) domains vesicle-mediated transport|protein secretion|ubiquitin-dependent protein catabolic process ubiquitin binding|SNARE binding|aspartic-type endopeptidase activity plasma membrane
YKR035W-A YKR035W-A DID2 hom Verified 1.03978585963056 0.149219700036591 no 716 0.149778988962329 528 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM Class E protein of the vacuolar protein-sorting (Vps) pathway; binds Vps4p and directs it to dissociate ESCRT-III complexes; forms a functional and physical complex with Ist1p; human ortholog may be altered in breast tumors late endosome to vacuole transport via multivesicular body sorting pathway|late endosome to vacuole transport|protein targeting to vacuole molecular_function late endosome|cytoplasm
YJL135W_d YJL135W YJL135W hom Dubious 1.03893186857624 0.149418211880169 no 717 0.126370710748197 427 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3 Unknown Unknown Unknown
YHR143W YHR143W DSE2 hom Verified 1.03892139082302 0.149420648548004 no 718 0.206864701658518 744 NA FF|FT CELL WALL ORG/BIOGENESIS|CELL DIVISION Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP cytokinesis, completion of separation|pseudohyphal growth glucosidase activity extracellular region|fungal-type cell wall
YML024W YML024W RPS17A hom Verified 1.03789775269155 0.149658829957182 no 719 0.138862799757188 473 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17A has a paralog, RPS17B, that arose from the whole genome duplication cytoplasmic translation|ribosomal small subunit assembly structural constituent of ribosome cytosolic small ribosomal subunit
YJR024C YJR024C MDE1 hom Verified 1.03165150488872 0.151117701538745 no 720 0.137198560758467 462 NA FT KETONE METABOLISM|AMINO ACID METABOLISM 5'-methylthioribulose-1-phosphate dehydratase; acts in the methionine salvage pathway; potential Smt3p sumoylation substrate; expression downregulated by caspofungin and deletion mutant is caspofungin resistant L-methionine salvage from methylthioadenosine methylthioribulose 1-phosphate dehydratase activity cytoplasm
YAL023C YAL023C PMT2 hom Verified 1.03126285437909 0.151208786254647 no 721 0.185934856088957 640 NA FT PROTEIN LOCALIZATION|CARBOHYDRATE METABOLISM|PROTEOLYSIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein O-mannosyltransferase of the ER membrane; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; involved in ER quality control; acts in a complex with Pmt1p, can instead interact with Pmt5p; antifungal drug target; PMT2 has a paralog, PMT3, that arose from the whole genome duplication ER-associated misfolded protein catabolic process|protein O-linked glycosylation|Unknown|protein exit from endoplasmic reticulum|protein O-linked mannosylation dolichyl-phosphate-mannose-protein mannosyltransferase activity integral to membrane|dolichyl-phosphate-mannose-protein mannosyltransferase complex
YOR332W YOR332W VMA4 hom Verified 1.03116614629478 0.151231456579519 no 722 0.166408001145726 580 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Subunit E of the V1 domain of the vacuolar H+-ATPase (V-ATPase); V-ATPase is an electrogenic proton pump found throughout the endomembrane system; V1 domain has eight subunits; required for the V1 domain to assemble onto the vacuolar membrane; protein abundance increases in response to DNA replication stress vacuolar acidification proton-transporting ATPase activity, rotational mechanism vacuolar proton-transporting V-type ATPase, V1 domain|fungal-type vacuole membrane|integral to membrane
YML124C YML124C TUB3 hom Verified 1.03016358829037 0.151466609599793 no 723 0.229351806874936 810 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|NUCLEOTIDE METABOLISM|CHROMOSOME SEGREGATION NUCLEUS|CYTOSKELETON Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication nuclear migration along microtubule|nuclear migration involved in conjugation with cellular fusion|homologous chromosome segregation|mitotic sister chromatid segregation structural constituent of cytoskeleton tubulin complex|cytoplasmic microtubule|kinetochore microtubule|nuclear microtubule|spindle pole body|polar microtubule
YKR094C YKR094C RPL40B hom Verified 1.02960766780799 0.15159710716 no 724 0.146423208221256 530 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RESPONSE TO DNA DAMAGE|TRANSLATION NUCLEUS|MITOCHONDRION RIBOSOME Ubiquitin-ribosomal 60S subunit protein L40B fusion protein; cleaved to yield ubiquitin and ribosomal protein L40B; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40B has a paralog, RPL40A, that arose from the whole genome duplication cytoplasmic translation|protein ubiquitination|ribosome biogenesis structural constituent of ribosome|protein tag mitochondrion|cytosolic large ribosomal subunit
YGR276C YGR276C RNH70 hom Verified 1.02950773162398 0.151620574244052 no 725 0.148418925545231 508 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS 3'-5' exoribonuclease; required for maturation of 3' ends of 5S rRNA and tRNA-Arg3 from dicistronic transcripts U5 snRNA 3'-end processing|generation of mature 3'-end of 5S rRNA generated by RNA polymerase III|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|tRNA 3'-trailer cleavage, exonucleolytic 3'-5'-exoribonuclease activity|3'-5' exonuclease activity nucleus
YGL089C YGL089C MF(ALPHA)2 hom Verified 1.02868618961908 0.151813580819769 no 726 0.142183959103553 483 NA FT SIGNALING Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed than MF(ALPHA)2 pheromone-dependent signal transduction involved in conjugation with cellular fusion mating pheromone activity extracellular region
YDR316W YDR316W OMS1 hom Verified 1.02816237887996 0.151936725958256 no 727 0.178296685402743 644 NA FT MITOCHONDRION Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif; multicopy suppressor of respiratory defects caused by OXA1 mutations biological_process S-adenosylmethionine-dependent methyltransferase activity mitochondrial envelope|mitochondrion
YGL257C YGL257C MNT2 hom Verified 1.02809261835073 0.151953131296035 no 728 0.151074572287752 494 NA FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans protein O-linked glycosylation alpha-1,3-mannosyltransferase activity cellular_component
YOL004W YOL004W SIN3 hom Verified 1.02806474682916 0.151959686072486 no 729 0.152582594783235 586 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CELL DIVISION|GENE SILENCING NUCLEUS|CHROMOSOME Component of the Sin3p-Rpd3p histone deacetylase complex, involved in transcriptional repression and activation of diverse processes, including mating-type switching and meiosis; involved in the maintenance of chromosomal integrity positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of chromatin silencing at rDNA|histone deacetylation|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of transcription from RNA polymerase I promoter|negative regulation of transcription during meiosis|regulation of DNA-dependent DNA replication initiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of chromatin silencing at telomere|double-strand break repair via nonhomologous end joining|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription involved in G2/M-phase of mitotic cell cycle transcription coactivator activity|transcription corepressor activity Sin3-type complex|Rpd3S complex|Rpd3L-Expanded complex|Rpd3L complex
YPR074C YPR074C TKL1 hom Verified 1.02724643364611 0.152152219269328 no 730 0.197544746092398 689 NA FF|FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication pentose-phosphate shunt transketolase activity cytoplasm
YIL028W_d YIL028W YIL028W hom Dubious 1.02684442236159 0.152246864025208 no 731 0.164584638492509 508 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPL051W YPL051W ARL3 hom Verified 1.02646417903487 0.152336419953015 no 732 0.194556705429984 708 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING ENDOMEMBRANE SYSTEM|GOLGI APPARATUS GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor intracellular protein transport|Golgi to plasma membrane protein transport|protein localization to organelle GTPase activity Golgi apparatus|nuclear outer membrane-endoplasmic reticulum membrane network
YDR277C YDR277C MTH1 hom Verified 1.02561548095989 0.152536433700336 no 733 0.143454587050268 447 NA FT SIGNALING Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation glucose transport|signal transduction molecular_function cellular_component
YPL110C YPL110C GDE1 hom Verified 1.02399992420003 0.152917655355413 no 734 0.155880853842678 543 NA FT LIPID METABOLISM|SIGNALING|CARBOHYDRATE METABOLISM Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes glycerophospholipid catabolic process glycerophosphocholine phosphodiesterase activity ribosome|cytoplasm
YMR083W YMR083W ADH3 hom Verified 1.02350121406668 0.153035463085001 no 735 0.164554470532188 572 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production NADH oxidation|fermentation|amino acid catabolic process to alcohol via Ehrlich pathway alcohol dehydrogenase (NAD) activity mitochondrion|mitochondrial matrix
YPL167C YPL167C REV3 hom Verified 1.02334768057206 0.153071743621628 no 736 0.157737813557596 561 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION|CHROMOSOME Catalytic subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair error-prone translesion synthesis|error-free translesion synthesis DNA-directed DNA polymerase activity nuclear chromatin|mitochondrion|zeta DNA polymerase complex
YBR175W YBR175W SWD3 hom Verified 1.02323349707495 0.153098729303661 no 737 0.150106903023197 546 NA FT CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5 histone H3-K4 methylation|telomere maintenance|chromatin silencing at telomere histone methyltransferase activity (H3-K4 specific) Set1C/COMPASS complex
YDR204W YDR204W COQ4 hom Verified 1.02092884784472 0.15364407520855 no 738 0.140399043055717 510 NA FT KETONE METABOLISM|COFACTOR METABOLISM MITOCHONDRION Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex ubiquinone biosynthetic process molecular_function mitochondrial inner membrane
YML047W-A_d YML047W-A YML047W-A hom Dubious 1.02007808372581 0.153845714963774 no 739 0.148205184379588 505 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPL158C YPL158C AIM44 hom Verified 1.01998769584226 0.153867148099986 no 740 0.195299331220624 650 NA FT SITE OF POLARIZED GROWTH Protein of unknown function; GFP-fusion protein localizes to the bud neck; transcription is regulated by Swi5p; null mutant displays elevated frequency of mitochondrial genome loss; relocalizes from bud neck to cytoplasm upon DNA replication stress biological_process molecular_function cellular bud neck
YKR085C YKR085C MRPL20 hom Verified 1.01880356205608 0.154148117157897 no 741 0.165946046095867 594 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YDR379C-A YDR379C-A YDR379C-A hom Verified 1.0174629028979 0.154466635642922 no 742 0.170350203600383 599 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; mutations in human ortholog SDHAF1 are associated with infantile leukoencephalopathy mitochondrial respiratory chain complex II assembly molecular_function mitochondrion
YBL039C YBL039C URA7 hom Verified 1.01557806611247 0.154915177065009 no 743 0.159609750823703 585 NA FT KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM Major CTP synthase isozyme (see also URA8); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA7 has a paralog, URA8, that arose from the whole genome duplication pyrimidine nucleobase biosynthetic process|CTP biosynthetic process|phospholipid biosynthetic process CTP synthase activity cytosol
YKL162C-A_d YKL162C-A YKL162C-A hom Dubious 1.01521101192366 0.155002626253577 no 744 0.143623845011585 522 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOR314W_d YOR314W YOR314W hom Dubious 1.01465154534178 0.15513597962255 no 745 0.149344106015026 555 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPL105C YPL105C SYH1 hom Verified 1.01445389240304 0.155183109894689 no 746 0.150600583156101 573 NA FT PROTEIN LOCALIZATION MITOCHONDRION Protein of unknown function that influences nuclear pore distribution; co-purifies with ribosomes; contains a GYF domain, which bind proline-rich sequences; deletion extends chronological lifespan; SYH1 has a paralog, SMY2, that arose from the whole genome duplication nuclear pore distribution molecular_function mitochondrion|ribosome|cytoplasmic mRNA processing body|extrinsic to membrane|cytoplasm
YPL186C YPL186C UIP4 hom Verified 1.01408682535586 0.155270661973942 no 747 0.184473916944535 607 NA FT ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION Protein that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope biological_process molecular_function mitochondrial outer membrane|nuclear envelope|endoplasmic reticulum
YGR217W YGR217W CCH1 hom Verified 1.01389152992138 0.155317256725221 no 748 0.152303522236119 507 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together calcium ion transport voltage-gated calcium channel activity|calcium channel activity integral to membrane|plasma membrane
YLR402W_d YLR402W YLR402W hom Dubious 1.01386275913008 0.155324121812249 no 749 0.168547839992011 548 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YBR034C YBR034C HMT1 hom Verified 1.01192529115615 0.155786887822668 no 750 0.174439720254939 581 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA LOCALIZATION NUCLEUS Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs, including Npl3p and Hrp1p, affecting their activity and nuclear export; methylates U1 snRNP protein Snp1p and ribosomal protein Rps2p; interacts genetically with genes encoding components of Rpd3(L) and this interaction is important for Rpd3 recruitment to the subtelomeric region. mRNA export from nucleus|negative regulation of DNA-dependent transcription, termination|positive regulation of transcription elongation from RNA polymerase II promoter|peptidyl-arginine methylation protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity nucleus
YBR085W YBR085W AAC3 hom Verified 1.01063952663159 0.156094495191811 no 751 0.138575430712632 501 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Aac1p; has roles in maintenance of viability and in respiration; AAC3 has a paralog, PET9, that arose from the whole genome duplication heme biosynthetic process|heme transport|anaerobic respiration|transmembrane transport ATP:ADP antiporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YNR041C YNR041C COQ2 hom Verified 1.0095775940438 0.156348854416687 no 752 0.154889702611601 527 NA FT KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM MITOCHONDRION Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis ubiquinone biosynthetic process 4-hydroxybenzoate octaprenyltransferase activity mitochondrion|integral to mitochondrial membrane|integral to membrane
YPL147W YPL147W PXA1 hom Verified 1.00883601345212 0.156526643180227 no 753 0.1462957970008 500 NA FT NUCLEOTIDE METABOLISM Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter ABCD1 and ABCD2 and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder fatty acid transport ATPase activity, coupled to transmembrane movement of substances integral to membrane|integral to peroxisomal membrane
YFL028C YFL028C CAF16 hom Verified 1.00835106868406 0.156642977254844 no 754 0.144176089092923 513 NA FT TRANSCRIPTION FROM RNA POL II|NUCLEOTIDE METABOLISM NUCLEUS Part of evolutionarily-conserved CCR4-NOT regulatory complex; contains single ABC-type ATPase domain but no transmembrane domain; interacts with several subunits of Mediator regulation of transcription from RNA polymerase II promoter ATPase activity CCR4-NOT complex|cytoplasm
YDR457W YDR457W TOM1 hom Verified 1.00775406174189 0.156786272223217 no 755 0.132904363375287 525 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|PROTEOLYSIS|RNA LOCALIZATION NUCLEUS E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones; interacts with Dia2p and is required for Dia2p degradation; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|mitosis|nucleocytoplasmic transport|nucleus organization|cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|regulation of cell size|protein ubiquitination ubiquitin-protein ligase activity integral to membrane|nucleolus|nucleus
YJR010C-A YJR010C-A SPC1 hom Verified 1.00761586685071 0.156819454367782 no 756 0.15954008981928 574 NA FT PROTEIN LOCALIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Subunit of the signal peptidase complex (SPC); SPC cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER); homolog of the SPC12 subunit of mammalian signal peptidase complex; protein abundance increases in response to DNA replication stress signal peptide processing|protein targeting to ER molecular_function signal peptidase complex
YGL002W YGL002W ERP6 hom Verified 1.00675091460227 0.157027244081644 no 757 0.168134958566425 532 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication ER to Golgi vesicle-mediated transport molecular_function mitochondrion|integral to membrane
YMR271C YMR271C URA10 hom Verified 1.00460671484258 0.157543131324051 no 758 0.136922252917669 520 NA FT NUCLEOTIDE METABOLISM Minor orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA10 has a paralog, URA5, that arose from the whole genome duplication 'de novo' pyrimidine nucleobase biosynthetic process|pyrimidine ribonucleoside biosynthetic process orotate phosphoribosyltransferase activity cytoplasm
YBL044W_p YBL044W YBL044W hom Uncharacterized 1.00415436938556 0.157652106215666 no 759 0.153660873120497 514 NA Putative protein of unknown function; YBL044W is not an essential protein biological_process molecular_function cellular_component
YBL080C YBL080C PET112 hom Verified 1.00330473534942 0.157856926036712 no 760 0.191333503743453 670 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; mutation is functionally complemented by the bacterial GatB ortholog glutaminyl-tRNAGln biosynthesis via transamidation|mitochondrial translation glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity mitochondrion|glutamyl-tRNA(Gln) amidotransferase complex
YDR494W YDR494W RSM28 hom Verified 1.00287996788517 0.157959389492912 no 761 0.163088055289655 613 NA FT TRANSLATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit; genetic interactions suggest a possible role in promoting translation initiation cytoplasmic translation|translational initiation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YNL089C_d YNL089C YNL089C hom Dubious 1.00286604573706 0.157962748566757 no 762 0.157349337741779 572 NA Dubious open reading frame unlikely to encode a functional protein; almost completely overlaps YNL090W/RHO2 which encodes a small GTPase of the Rho/Rac subfamily of Ras-like proteins Unknown Unknown Unknown
YDR300C YDR300C PRO1 hom Verified 1.00264036522859 0.158017206296026 no 763 0.162384890449809 544 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Gamma-glutamyl kinase; catalyzes the first step in proline biosynthesis; PRO1 has a paralog, YHR033W, that arose from the whole genome duplication proline biosynthetic process glutamate 5-kinase activity cytoplasm
YER122C YER122C GLO3 hom Verified 1.00254426880092 0.158040398540479 no 764 0.161671570015729 556 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|NUCLEOTIDE METABOLISM ENDOMEMBRANE SYSTEM|GOLGI APPARATUS ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Gcs1p retrograde vesicle-mediated transport, Golgi to ER|COPI coating of Golgi vesicle|ER to Golgi vesicle-mediated transport ARF GTPase activator activity COPI-coated vesicle|endoplasmic reticulum-Golgi intermediate compartment|COPI vesicle coat
YLR265C YLR265C NEJ1 hom Verified 1.00204967917816 0.158159799857188 no 765 0.145478139678039 467 NA FT RESPONSE TO DNA DAMAGE ENDOMEMBRANE SYSTEM|NUCLEUS Protein involved in regulation of nonhomologous end joining; interacts with DNA ligase IV components Dnl4p and Lif1p; repressed by MAT heterozygosity; regulates cellular distribution of Lif1p double-strand break repair via nonhomologous end joining|double-strand break repair via single-strand annealing DNA end binding DNA ligase IV complex|nucleus
YMR310C_p YMR310C YMR310C hom Uncharacterized 1.00174150755224 0.158234227017381 no 766 0.164809377209193 571 NA FT NUCLEUS Putative S-adenosylmethionine-dependent methyltransferase; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR310C is not an essential gene biological_process S-adenosylmethionine-dependent methyltransferase activity nucleus
YCR059C YCR059C YIH1 hom Verified 1.00133175278598 0.158333223320353 no 767 0.157075189140202 573 NA FT TRANSLATION|PROTEIN PHOSPHORYLATION NUCLEUS Negative regulator of eIF2 kinase Gcn2p; competes with Gcn2p for binding to Gcn1p; may contribute to regulation of translation in response to starvation via regulation of Gcn2p; binds to monomeric actin and to ribosomes and polyribosomes; ortholog of mammalian IMPACT negative regulation of protein phosphorylation protein kinase inhibitor activity|ribosome binding|actin monomer binding ribosome|nucleus|polysome|cytoplasm
YBR178W_d YBR178W YBR178W hom Dubious 0.999408648288806 0.158798386041657 no 768 0.16664953646976 572 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR177C Unknown Unknown Unknown
YGR014W YGR014W MSB2 hom Verified 0.999000890724062 0.158897129896739 no 769 0.194527731473511 652 NA FT SIGNALING SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Mucin family member involved in signaling; functions in the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; is processed into secreted and cell-associated forms by the aspartyl protease, Yps1p; also functions as an osmosensor in parallel to the Sho1p-mediated pathway; potential Cdc28p substrate signal transduction involved in filamentous growth|osmosensory signaling pathway via Sho1 osmosensor|establishment of cell polarity|hyperosmotic response|response to osmotic stress osmosensor activity site of polarized growth|integral to plasma membrane
YKR080W YKR080W MTD1 hom Verified 0.998981916510295 0.158901725731661 no 770 0.169846421592265 565 NA FT OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM NUCLEUS NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline folic acid-containing compound biosynthetic process|one-carbon metabolic process|purine nucleobase biosynthetic process methylenetetrahydrofolate dehydrogenase (NAD+) activity cytosol
YDR017C YDR017C KCS1 hom Verified 0.99854303272921 0.159008054179597 no 771 0.149297536758739 547 NA Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response and telomere maintenance inositol phosphate biosynthetic process inositol heptakisphosphate kinase activity|inositol hexakisphosphate kinase activity|inositol-1,3,4,5,6-pentakisphosphate kinase activity|inositol heptakisphosphate 5-kinase activity cytoplasm
YMR008C YMR008C PLB1 hom Verified 0.998205041526781 0.15908997113332 no 772 0.151738534985653 489 NA FT LIPID METABOLISM PLASMA MEMBRANE Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol glycerophospholipid metabolic process lysophospholipase activity periplasmic space|plasma membrane
YPR059C_d YPR059C YPR059C hom Dubious 0.997633704284096 0.159228505659672 no 773 0.172174832712477 652 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YMC1/YPR058W Unknown Unknown Unknown
YER068W YER068W MOT2 hom Verified 0.997507161491099 0.159259199703327 no 774 0.17426481618021 575 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications deadenylation-independent decapping of nuclear-transcribed mRNA|positive regulation of transcription elongation from RNA polymerase II promoter|protein polyubiquitination|protein ubiquitination ubiquitin-protein ligase activity|sequence-specific DNA binding CCR4-NOT core complex|cytoplasm
YDR179C YDR179C CSN9 hom Verified 0.992838660943719 0.160394292985656 no 775 0.155914379903249 504 NA FT SIGNALING NUCLEUS Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|cullin deneddylation molecular_function signalosome
YPL031C YPL031C PHO85 hom Verified 0.992482997868135 0.160480984635775 no 776 0.198033071568184 653 NA FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES A NUCLEUS Cyclin-dependent kinase, with ten cyclin partners; involved in regulating the cellular response to nutrient levels and environmental conditions and progression through the cell cycle regulation of transcription involved in G1/S phase of mitotic cell cycle|negative regulation of calcium-mediated signaling|regulation of protein stability|regulation of protein localization|protein phosphorylation|response to DNA damage stimulus|negative regulation of phosphate metabolic process|fungal-type cell wall organization|regulation of establishment or maintenance of cell polarity|negative regulation of glycogen biosynthetic process|negative regulation of transcription from RNA polymerase II promoter|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of macroautophagy|negative regulation of macroautophagy protein kinase activity|cyclin-dependent protein kinase activity cyclin-dependent protein kinase holoenzyme complex|nucleus
YDL233W_p YDL233W MFG1 hom Uncharacterized 0.991894194397753 0.160624570731115 no 777 0.149150606670431 514 NA FT NUCLEUS Regulator of filamentous growth; interacts with FLO11 promoter and regulates FLO11 expression; binds to transcription factors Flo8p and Mss11p; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YDL233W is not an essential gene biological_process molecular_function nucleus|cytoplasm
YJR001W YJR001W AVT1 hom Verified 0.991772141110966 0.160654345241663 no 778 0.199003557815236 685 NA FT VACUOLAR TRANSPORT Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters amino acid transport|vacuolar transport transporter activity|L-glutamine transmembrane transporter activity|L-isoleucine transmembrane transporter activity|L-tyrosine transmembrane transporter activity fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YGR053C_p YGR053C YGR053C hom Uncharacterized 0.990768668541329 0.160899275813835 no 779 0.159187591546966 578 NA Putative protein of unknown function biological_process molecular_function cellular_component
YCR049C_d YCR049C YCR049C hom Dubious 0.99010584716764 0.161061192839728 no 780 0.185727158510449 635 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YNL135C YNL135C FPR1 hom Verified 0.98573681879262 0.16213113844629 no 781 0.17937820459696 640 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|CHROMATIN ORGANIZATION NUCLEUS|MITOCHONDRION Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function protein folding|chromatin organization|homoserine metabolic process peptidyl-prolyl cis-trans isomerase activity|macrolide binding mitochondrion|nucleus|cytoplasm
YKR100C YKR100C SKG1 hom Verified 0.98331397768367 0.162726466421128 no 782 0.172344210500963 618 NA FT CELL WALL ORG/BIOGENESIS SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Transmembrane protein with a role in cell wall polymer composition; localizes on the inner surface of the plasma membrane at the bud and in the daughter cell fungal-type cell wall organization molecular_function incipient cellular bud site|cellular bud|cellular bud tip
YNL087W YNL087W TCB2 hom Verified 0.982710845421245 0.162874885706704 no 783 0.166603219466448 573 NA FT ENDOPLASMIC RETICULUM|PLASMA MEMBRANE ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains 3 calcium and lipid binding domains; mRNA is targeted to the bud biological_process lipid binding cellular bud|cortical endoplasmic reticulum
YDL021W YDL021W GPM2 hom Verified 0.982427282258059 0.162944695575062 no 784 0.169524805541091 574 NA FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event biological_process phosphoglycerate mutase activity|molecular_function cytosol|cytoplasm
YLR028C YLR028C ADE16 hom Verified 0.981951657849055 0.163061832303892 no 785 0.152778098350762 491 NA FT OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE16 has a paralog, ADE17, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine ascospore formation|'de novo' IMP biosynthetic process|purine nucleotide biosynthetic process|aerobic respiration phosphoribosylaminoimidazolecarboxamide formyltransferase activity|IMP cyclohydrolase activity cytosol
YNL063W YNL063W MTQ1 hom Verified 0.981641654743483 0.163138209291761 no 786 0.170171692885094 591 NA FT TRANSLATION MITOCHONDRION S-adenosylmethionine-dependent methyltransferase; methylates translational release factor Mrf1p; similar to E.coli PrmC; is not an essential gene translational readthrough S-adenosylmethionine-dependent methyltransferase activity mitochondrion
YGR183C YGR183C QCR9 hom Verified 0.979758078534964 0.16360277491915 no 787 0.164522572062422 584 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex iron-sulfur cluster assembly|mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration ubiquinol-cytochrome-c reductase activity mitochondrion|integral to membrane|mitochondrial respiratory chain complex III
YDR006C YDR006C SOK1 hom Verified 0.979589413276748 0.163644416415255 no 788 0.148532424926504 481 NA FT SIGNALING NUCLEUS Protein whose overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13 cAMP-mediated signaling molecular_function nucleus
YKL123W_d YKL123W YKL123W hom Dubious 0.978348288058974 0.163951047436532 no 789 0.17561402171163 583 NA Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene SSH4 Unknown Unknown Unknown
YLR031W_p YLR031W YLR031W hom Uncharacterized 0.977840958653017 0.164076494947116 no 790 0.177792367639361 615 NA Putative protein of unknown function biological_process molecular_function cellular_component
YEL056W YEL056W HAT2 hom Verified 0.976554731318837 0.164394819769322 no 791 0.140859221999416 490 NA FT CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING NUCLEUS HISTONE ACETYLTRANSFERASE Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing histone acetylation|chromatin assembly or disassembly|chromatin silencing at telomere histone acetyltransferase activity|histone binding histone acetyltransferase complex|nucleus|cytoplasm
YOL063C YOL063C CRT10 hom Verified 0.974411993166091 0.164926008489479 no 792 0.151510442683779 530 NA FT TRANSCRIPTION FROM RNA POL II Protein involved in transcriptional regulation of RNR2 and RNR3; expression of the gene is induced by DNA damage and null mutations confer increased resistance to hydroxyurea; N-terminal region has a leucine repeat and a WD40 repeat regulation of transcription from RNA polymerase II promoter molecular_function cellular_component
YEL033W_p YEL033W MTC7 hom Uncharacterized 0.973353285658899 0.165188873827152 no 793 0.210408304595286 723 NA Predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant biological_process molecular_function cellular_component
YDR032C YDR032C PST2 hom Verified 0.971002572629078 0.16577349874134 no 794 0.149423206996595 550 NA FT OXIDATION-REDUCTION PROCESS MITOCHONDRION Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication biological_process molecular_function mitochondrion|membrane raft|plasma membrane|cytoplasm
YNL217W_p YNL217W YNL217W hom Uncharacterized 0.97029330070185 0.165950157816542 no 795 0.152106239604375 526 NA Putative protein of unknown function; weak sequence similarity to bis (5'-nucleotidyl)-tetraphosphatases; (GFP)-fusion protein localizes to the vacuole; null mutant is highly sensitive to azaserine and resistant to sodium-O-vandate biological_process phosphatase activity fungal-type vacuole
YDR135C YDR135C YCF1 hom Verified 0.970191047752046 0.165975636092653 no 796 0.142385849965764 506 NA FT NUCLEOTIDE METABOLISM Vacuolar glutathione S-conjugate transporter; member of the ATP-binding cassette family; has a role in detoxifying metals such as cadmium, mercury, and arsenite; also transports unconjugated bilirubin, selenodigluthatione, and oxidized glutathione; similar to human cystic fibrosis protein CFTR bilirubin transport|response to metal ion|transmembrane transport bilirubin transmembrane transporter activity|glutathione S-conjugate-exporting ATPase activity fungal-type vacuole membrane|integral to membrane
YDR148C YDR148C KGD2 hom Verified 0.968428008168439 0.166415328590048 no 797 0.167056046702273 583 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated tricarboxylic acid cycle|mitochondrial genome maintenance|2-oxoglutarate metabolic process dihydrolipoyllysine-residue succinyltransferase activity mitochondrial nucleoid|mitochondrion|mitochondrial oxoglutarate dehydrogenase complex
YAL049C YAL049C AIM2 hom Verified 0.967416759437845 0.166667867618945 no 798 0.155733549329044 571 NA Cytoplasmic protein involved in mitochondrial function or organization; null mutant displays reduced frequency of mitochondrial genome loss; potential Hsp82p interactor biological_process molecular_function cytoplasm
YDL123W YDL123W SNA4 hom Verified 0.965839697614051 0.167062200403448 no 799 0.183119885304569 557 NA Protein of unknown function, localized to the vacuolar outer membrane; predicted to be palmitoylated biological_process molecular_function fungal-type vacuole lumen|fungal-type vacuole membrane
YDR496C YDR496C PUF6 hom Verified 0.965682035835259 0.167101655630588 no 800 0.144131735137795 496 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION NUCLEUS|SITE OF POLARIZED GROWTH RIBOSOME Pumilio-homology domain protein that binds the 3' UTR of ASH1 mRNA and represses its translation, resulting in proper asymmetric localization of ASH1 mRNA; also co-sediments with the 60S ribosomal subunit and is required for its biogenesis ribosomal large subunit biogenesis|negative regulation of translation mRNA 3'-UTR binding|translation repressor activity, nucleic acid binding nucleolus|nucleus|large ribosomal subunit
YBR289W YBR289W SNF5 hom Verified 0.964232412086825 0.167464708894715 no 801 0.1797297749764 530 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS NUCLEUS|CHROMOSOME RSC COMPLEX Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf6p; relocates to the cytosol under hypoxic conditions sucrose catabolic process|double-strand break repair via homologous recombination|chromatin remodeling|carbon catabolite activation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II activating transcription factor binding SWI/SNF complex|nucleus
YHR136C YHR136C SPL2 hom Verified 0.96409580517852 0.167498947806599 no 802 0.179270547112977 626 NA Protein with similarity to cyclin-dependent kinase inhibitors; downregulates low-affinity phosphate transport during phosphate limitation; overproduction suppresses a plc1 null mutation; GFP-fusion protein localizes to the cytoplasm response to temperature stimulus enzyme inhibitor activity cytoplasm
YBL039W-B_p YBL039W-B YBL039W-B hom Uncharacterized 0.963879104891138 0.167553270430937 no 803 0.151151896859219 541 NA Putative protein of unknown function biological_process molecular_function cellular_component
YPR004C YPR004C AIM45 hom Verified 0.963697809092489 0.167598726544153 no 804 0.165219441085713 607 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-alpha; interacts with frataxin, Yfh1p; null mutant displays elevated frequency of mitochondrial genome loss; may have a role in oxidative stress response biological_process molecular_function mitochondrion
YDL068W_d YDL068W YDL068W hom Dubious 0.963589063996262 0.167625995903597 no 805 0.193599943079861 686 NA Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOR089C YOR089C VPS21 hom Verified 0.962947569780697 0.167786917731704 no 806 0.234244994742848 821 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|VACUOLAR TRANSPORT MITOCHONDRION Rab family GTPase; required for endocytic transport and for sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog; protein abundance increases in response to DNA replication stress; VPS21 has a paralog, YPT53, that arose from the whole genome duplication endocytosis|vacuole inheritance|protein targeting to vacuole GTP binding|GTPase activity mitochondrial outer membrane|late endosome|mitochondrion
YER099C YER099C PRS2 hom Verified 0.961255903620196 0.168211756954513 no 807 0.159548312805813 582 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS2 has a paralog, PRS4, that arose from the whole genome duplication fungal-type cell wall organization|5-phosphoribose 1-diphosphate biosynthetic process ribose phosphate diphosphokinase activity cytoplasm
YDR271C_d YDR271C YDR271C hom Dubious 0.961123088856943 0.168245140871038 no 808 0.20376419590399 696 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W Unknown Unknown Unknown
YKL008C YKL008C LAC1 hom Verified 0.961037838774205 0.168266571319252 no 809 0.160659722706855 569 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p replicative cell aging|ceramide biosynthetic process sphingosine N-acyltransferase activity integral to membrane|endoplasmic reticulum
YKL053C-A YKL053C-A MDM35 hom Verified 0.959611534225795 0.16862538090822 no 810 0.181657231812801 625 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION NUCLEUS|MITOCHONDRION Mitochondrial intermembrane space protein; mutation affects mitochondrial distribution and morphology; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress mitochondrion organization|mitochondrial respiratory chain complex assembly molecular_function nucleus|cytoplasm|mitochondrial intermembrane space
YKL090W YKL090W CUE2 hom Verified 0.958847789203254 0.168817715147136 no 811 0.159663461438799 574 NA Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination biological_process ubiquitin binding cellular_component
YPR073C YPR073C LTP1 hom Verified 0.95838371275238 0.168934652540312 no 812 0.152304625389945 551 NA FT NUCLEUS Protein phosphotyrosine phosphatase of unknown cellular role; activated by adenine protein dephosphorylation protein tyrosine phosphatase activity nucleus|cytoplasm
YLR122C_d YLR122C YLR122C hom Dubious 0.957952658409547 0.169043315665063 no 813 0.173703731908305 587 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C Unknown Unknown Unknown
YBR208C YBR208C DUR1,2 hom Verified 0.957576159541677 0.169138262791706 no 814 0.154488122104672 547 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Urea amidolyase; contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; protein abundance increases in response to DNA replication stress allantoin catabolic process|urea catabolic process urea carboxylase activity|allophanate hydrolase activity cytoplasm
YBL002W YBL002W HTB2 hom Verified 0.957061122455941 0.169268202542147 no 815 0.142756722586133 484 NA FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB1; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation chromatin assembly or disassembly DNA binding replication fork protection complex|nuclear nucleosome
YFR026C YFR026C ULI1 hom Verified 0.953909410436741 0.170064749805115 no 816 0.170121216013361 566 NA FT SIGNALING Putative protein of unknown function involved in and induced by the endoplasmic reticulum unfolded protein response endoplasmic reticulum unfolded protein response molecular_function cellular_component
YHR163W YHR163W SOL3 hom Verified 0.953869488953247 0.170074854736273 no 817 0.165007763080884 598 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS NUCLEUS 6-phosphogluconolactonase; catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p; SOL3 has a paralog, SOL4, that arose from the whole genome duplication pentose-phosphate shunt, oxidative branch 6-phosphogluconolactonase activity nucleus|cytoplasm
YNL043C_d YNL043C YNL043C hom Dubious 0.953590215588375 0.170145555208733 no 818 0.174411265073016 611 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W Unknown Unknown Unknown
YBL100W-C_p YBL100W-C YBL100W-C hom Uncharacterized 0.950525194780397 0.170922729105282 no 819 0.167626391425134 581 NA Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YFL013C YFL013C IES1 hom Verified 0.949321085217628 0.171228666379783 no 820 0.203825121940626 665 NA FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Subunit of the INO80 chromatin remodeling complex nucleosome mobilization molecular_function nucleus|Ino80 complex
YGR157W YGR157W CHO2 hom Verified 0.947431480607533 0.171709477999309 no 821 0.17987541175673 583 NA FT LIPID METABOLISM Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis phosphatidylcholine biosynthetic process phosphatidylethanolamine N-methyltransferase activity integral to membrane|endoplasmic reticulum
YDR150W YDR150W NUM1 hom Verified 0.944416298495504 0.172478477971896 no 822 0.219549322098737 771 NA FT PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION MITOCHONDRION|SITE OF POLARIZED GROWTH Protein required for nuclear migration, localizes to the mother cell cortex and the bud tip; may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex mitochondrion inheritance|nuclear migration along microtubule|mitochondrial fission|microtubule cytoskeleton organization tubulin binding cell cortex|mitochondrion|cellular bud tip
YDL142C YDL142C CRD1 hom Verified 0.943581462501996 0.172691784410574 no 823 0.165898919096414 549 NA FT LIPID METABOLISM|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS MITOCHONDRION Cardiolipin synthase; produces cardiolipin, which is a phospholipid of the mitochondrial inner membrane that is required for normal mitochondrial membrane potential and function; also required for normal vacuolar ion homeostasis lipid biosynthetic process|cellular ion homeostasis|mitochondrial membrane organization cardiolipin synthase activity mitochondrion|integral to membrane
YPL107W_p YPL107W YPL107W hom Uncharacterized 0.942596346375565 0.172943704681078 no 824 0.165935181925226 576 NA FT MITOCHONDRION Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YPL107W is not an essential gene biological_process molecular_function mitochondrion
YDR285W YDR285W ZIP1 hom Verified 0.941597495667474 0.173199376198108 no 825 0.179872206979331 619 NA FT CELL CYCLE NUCLEUS|CHROMOSOME Transverse filament protein of the synaptonemal complex; required for normal levels of meiotic recombination and pairing between homologous chromosome during meiosis; potential Cdc28p substrate synapsis|reciprocal meiotic recombination chromatin binding|SUMO polymer binding transverse filament
YCL014W YCL014W BUD3 hom Verified 0.941523976146703 0.173218204179152 no 826 0.168937939988189 559 NA FT CELL CYCLE|SIGNALING|CELL DIVISION SITE OF POLARIZED GROWTH|CYTOSKELETON Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding cellular bud site selection|axial cellular bud site selection|cytokinesis molecular_function cellular bud neck contractile ring|cellular bud neck
YHR158C YHR158C KEL1 hom Verified 0.941021391686133 0.173346948449886 no 827 0.167730050539422 583 NA FT CELL CYCLE|MEMBRANE ORGANIZATION SITE OF POLARIZED GROWTH Protein required for proper cell fusion and cell morphology; functions in a complex with Kel2p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate negative regulation of exit from mitosis|regulation of cell shape|cell morphogenesis|cytogamy|plasma membrane fusion molecular_function mating projection tip|cellular bud neck|cytoplasm|cellular bud tip
YCL042W_p YCL042W YCL042W hom Uncharacterized 0.938661066513739 0.173952394430915 no 828 0.197198569008112 695 NA Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm biological_process molecular_function cytoplasm
YFL041W-A_p YFL041W-A YFL041W-A hom Uncharacterized 0.938402800749845 0.174018723584222 no 829 0.173563585923627 596 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YGR026W_p YGR026W YGR026W hom Uncharacterized 0.938382233840407 0.174024006375741 no 830 0.180365109167903 587 NA FT PLASMA MEMBRANE Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery biological_process molecular_function integral to membrane
YKL221W YKL221W MCH2 hom Verified 0.937851507953117 0.174160363246935 no 831 0.189009604220584 595 NA Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport transport monocarboxylic acid transmembrane transporter activity|transporter activity integral to membrane|membrane
YMR081C YMR081C ISF1 hom Verified 0.937502138382287 0.174250162158803 no 832 0.157868244775782 587 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant aerobic respiration molecular_function cellular_component
YPL114W_d YPL114W YPL114W hom Dubious 0.937258352825867 0.17431284010032 no 833 0.166621525428083 614 NA Dubious open reading frame, unlikely to encode a functional protein; largely overlaps ORF YPL113C; diploid deletion in BY4743 strain background exhibits high budding index Unknown Unknown Unknown
YLR185W YLR185W RPL37A hom Verified 0.937042656564985 0.174368308148737 no 834 0.166002806752482 546 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L37A; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37A has a paralog, RPL37B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YOR214C_p YOR214C YOR214C hom Uncharacterized 0.936781904667571 0.17443537759046 no 835 0.167209383333097 561 NA Putative protein of unknown function; YOR214C is not an essential gene biological_process molecular_function fungal-type cell wall
YOR367W YOR367W SCP1 hom Verified 0.935488722624082 0.174768246236516 no 836 0.194067812963547 683 NA FT CYTOSKELETON ORGANIZATION CYTOSKELETON Component of yeast cortical actin cytoskeleton, binds and cross links actin filaments; originally identified by its homology to calponin (contains a calponin-like repeat) but the Scp1p domain structure is more similar to transgelin actin filament organization|chronological cell aging actin filament binding|protein binding, bridging actin cortical patch
YPL134C YPL134C ODC1 hom Verified 0.932386306505426 0.175568459486816 no 837 0.165067739173505 607 NA FT MITOCHONDRION Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation mitochondrial transport dicarboxylic acid transmembrane transporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YJR018W_d YJR018W YJR018W hom Dubious 0.93162891698363 0.175764166762297 no 838 0.17808027869215 645 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGL115W YGL115W SNF4 hom Verified 0.930381526766476 0.176086789910439 no 839 0.192998783317319 678 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|PLASMA MEMBRANE Activating gamma subunit of the AMP-activated Snf1p kinase complex; additional subunits of the complex are Snf1p and a Sip1p/Sip2p/Gal83p family member; activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis; protein abundance increases in response to DNA replication stress positive regulation of gluconeogenesis|peroxisome organization|protein phosphorylation|replicative cell aging|regulation of transcription from RNA polymerase II promoter AMP-activated protein kinase activity|protein serine/threonine kinase activator activity AMP-activated protein kinase complex|plasma membrane|nucleus|nuclear envelope lumen|cytoplasm
YDR202C YDR202C RAV2 hom Verified 0.930337016063505 0.176098309015381 no 840 0.203387672606806 721 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS Subunit of RAVE (Rav1p, Rav2p, Skp1p), a complex that associates with the V1 domain of the vacuolar membrane (H+)-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme vacuolar acidification|regulation of protein complex assembly molecular_function RAVE complex
YER085C_p YER085C YER085C hom Uncharacterized 0.92987501845304 0.176217899416829 no 841 0.151913768010711 552 NA Putative protein of unknown function biological_process molecular_function cellular_component
YMR191W YMR191W SPG5 hom Verified 0.929816326914705 0.17623309569506 no 842 0.185937345843836 614 NA Protein required for proteasome assembly during quiescence; binds to base of the proteasome regulartory particle; required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources biological_process molecular_function cellular_component
YGR021W_p YGR021W YGR021W hom Uncharacterized 0.929809317196456 0.17623491069064 no 843 0.186745705381403 645 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YFR047C YFR047C BNA6 hom Verified 0.928836332467029 0.176486956131665 no 844 0.171003182442574 600 NA FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM NUCLEUS Quinolinate phosphoribosyl transferase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p de novo NAD biosynthetic process from tryptophan nicotinate-nucleotide diphosphorylase (carboxylating) activity nucleus|cytoplasm
YJR105W YJR105W ADO1 hom Verified 0.928826625379056 0.176489471838586 no 845 0.245231491676763 852 NA FF|FT NUCLEOTIDE METABOLISM NUCLEUS Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle purine nucleobase metabolic process adenosine kinase activity nucleus|cytoplasm
YML074C YML074C FPR3 hom Verified 0.927401121803111 0.176859154213502 no 846 0.155364843205012 511 NA FT CELL CYCLE|CHROMATIN ORGANIZATION NUCLEUS Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p meiotic recombination checkpoint peptidyl-prolyl cis-trans isomerase activity|macrolide binding nucleolus
YPR158W YPR158W CUR1 hom Verified 0.926689601171942 0.177043859096911 no 847 0.195416347469063 699 NA FT NUCLEUS Sorting factor, central regulator of spatial protein quality control; physically and functionally interacts with chaperones to promote sorting and deposition of misfolded proteins into cytosolic compartments; involved in destabilization of [URE3] prions; CUR1 has a paralog, BTN2, that arose from the whole genome duplication cellular response to stress|protein localization to nucleus chaperone binding nucleus
YMR196W_p YMR196W YMR196W hom Uncharacterized 0.926605457274516 0.17706571021394 no 848 0.197799337102521 676 NA FT CARBOHYDRATE METABOLISM Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene biological_process molecular_function cytoplasm
YHR209W YHR209W CRG1 hom Verified 0.926220696134973 0.177165649573391 no 849 0.17781040919057 644 NA S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin lipid homeostasis mRNA binding|S-adenosylmethionine-dependent methyltransferase activity|methyltransferase activity cellular_component
YKR102W YKR102W FLO10 hom Verified 0.923747553034221 0.177808883681811 no 850 0.155539186242648 483 NA Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth filamentous growth of a population of unicellular organisms|flocculation via cell wall protein-carbohydrate interaction|flocculation|invasive growth in response to glucose limitation mannose binding fungal-type cell wall
YLR341W YLR341W SPO77 hom Verified 0.922142936244783 0.178227011735931 no 851 0.182675337898045 599 NA FT CELL WALL ORG/BIOGENESIS Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis ascospore wall assembly|ascospore formation molecular_function intracellular
YPR198W YPR198W SGE1 hom Verified 0.921935540120777 0.178281099819524 no 852 0.224682983506096 796 NA FF|FT PLASMA MEMBRANE Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations response to drug|drug transport drug transmembrane transporter activity integral to membrane|integral to plasma membrane
YLR042C_p YLR042C YLR042C hom Uncharacterized 0.92035422200546 0.178693841337881 no 853 0.158525946885069 535 NA Protein of unknown function; localizes to the cytoplasm; YLL042C is not an essential gene biological_process molecular_function fungal-type cell wall
YMR042W YMR042W ARG80 hom Verified 0.920327073628101 0.178700932613849 no 854 0.174409602050402 572 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Transcription factor involved in regulation of arginine-responsive genes; acts with Arg81p and Arg82p Unknown|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding nucleus
YCL005W YCL005W LDB16 hom Verified 0.920220248800717 0.178728837450393 no 855 0.208662321722882 735 NA FT MITOCHONDRION Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria biological_process molecular_function mitochondrion|lipid particle
YMR242C YMR242C RPL20A hom Verified 0.91853331549368 0.179169862714912 no 856 0.177060692535434 645 NA FF|FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L20A; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20A has a paralog, RPL20B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YIL027C YIL027C EMC5 hom Verified 0.918450296968435 0.179191584412423 no 857 0.204872439441709 712 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response, and also shows K1 killer toxin resistance; homologous to worm B0334.15/EMC-5, fly CG15168, human MMGT protein folding in endoplasmic reticulum molecular_function ER membrane protein complex|endoplasmic reticulum
YMR119W YMR119W ASI1 hom Verified 0.918137069984896 0.17927355479028 no 858 0.226340665931409 757 NA FT PROTEOLYSIS ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Putative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals; ASI1 has a paralog, ASI3, that arose from the whole genome duplication ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity integral to membrane|nuclear inner membrane|endoplasmic reticulum membrane
YHR200W YHR200W RPN10 hom Verified 0.917021844972704 0.179565596576756 no 859 0.18142848688645 643 NA FT PROTEOLYSIS Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein ubiquitin-dependent protein catabolic process structural molecule activity|polyubiquitin binding proteasome complex|proteasome regulatory particle, base subcomplex
YDR537C_d YDR537C YDR537C hom Dubious 0.916551264537681 0.179688916203061 no 860 0.176854972484427 601 NA Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W Unknown Unknown Unknown
YDR225W YDR225W HTA1 hom Verified 0.915605420931861 0.179936943530066 no 861 0.187734883530555 674 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME RSC COMPLEX Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p DNA repair|chromatin assembly or disassembly|negative regulation of transcription from RNA polymerase II promoter DNA binding replication fork protection complex|nuclear nucleosome
YMR184W YMR184W ADD37 hom Verified 0.915347429775787 0.180004633514544 no 862 0.17904572293274 575 NA FT PROTEOLYSIS Protein of unknown function; involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene; protein abundance increases in response to DNA replication stress ER-associated protein catabolic process molecular_function cytoplasm
YEL020C_p YEL020C YEL020C hom Uncharacterized 0.913555702408817 0.180475175906382 no 863 0.188718565601462 644 NA Protein of unknown function with low sequence identity to Pdc1p; mRNA identified as translated by ribosome profiling data biological_process molecular_function cytoplasm
YLR070C YLR070C XYL2 hom Verified 0.913376228911128 0.180522351608915 no 864 0.18554521665565 601 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM Xylitol dehydrogenase, converts xylitol to D-xylulose; expression induced by xylose, even though this pentose sugar is not well utilized by S. cerevisiae; null mutant has cell wall defect xylulose biosynthetic process D-xylulose reductase activity cellular_component
YGR221C YGR221C TOS2 hom Verified 0.913009676902579 0.180618726066 no 865 0.169791059406003 608 NA FT CELL DIVISION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Protein involved in localization of Cdc24p to the site of bud growth; may act as a membrane anchor; localizes to the bud neck and bud tip; potentially phosphorylated by Cdc28p budding cell bud growth molecular_function cellular bud neck|cellular bud tip
YIR028W YIR028W DAL4 hom Verified 0.91191806536103 0.180905925441364 no 866 0.174025759051091 590 NA Allantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation allantoin catabolic process|allantoin transport allantoin uptake transmembrane transporter activity integral to membrane|membrane
YHR155W YHR155W YSP1 hom Verified 0.911670870397669 0.180971001338773 no 867 0.198755210037207 702 NA FF|FT MITOCHONDRION Mitochondrial protein; potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone; YSP1 has a paralog, SIP3, that arose from the whole genome duplication biological_process molecular_function mitochondrion
YDL238C YDL238C GUD1 hom Verified 0.908950576405082 0.181688107466754 no 868 0.18221989743373 608 NA Guanine deaminase, a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine; activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures guanine metabolic process guanine deaminase activity|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides cytoplasm
YBR220C_p YBR220C YBR220C hom Uncharacterized 0.907524993809008 0.182064619257443 no 869 0.179120529987342 604 NA Putative protein of unknown function; YBR220C is not an essential gene biological_process molecular_function integral to membrane
YKR053C YKR053C YSR3 hom Verified 0.90604411131779 0.182456252503509 no 870 0.190023937694645 641 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Dihydrosphingosine 1-phosphate phosphatase; membrane protein involved in sphingolipid metabolism; YSR3 has a paralog, LCB3, that arose from the whole genome duplication phospholipid dephosphorylation|sphingolipid biosynthetic process sphingosine-1-phosphate phosphatase activity integral to membrane|endoplasmic reticulum
YLR241W_p YLR241W YLR241W hom Uncharacterized 0.9057887960392 0.18252382616768 no 871 0.162199988191535 530 NA Putative protein of unknown function, may be involved in detoxification biological_process molecular_function integral to membrane
YML120C YML120C NDI1 hom Verified 0.905406691217046 0.182624986105141 no 872 0.153920725828333 531 NA FT OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION NADH:ubiquinone oxidoreductase; transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; involved in Mn and H2O2 induced apoptosis; upon apoptotic stress, Ndip is activated in the mitochondria by N-terminal cleavage, and the truncated protein translocates to the cytoplasm to induce apoptosis; homolog of human AMID mitochondrial electron transport, NADH to ubiquinone|NADH oxidation|chronological cell aging|positive regulation of apoptotic process NADH dehydrogenase (ubiquinone) activity mitochondrion|mitochondrial matrix
YLR139C YLR139C SLS1 hom Verified 0.905335692776918 0.182643786368456 no 873 0.21293293246425 718 NA FT TRANSLATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Mitochondrial membrane protein that coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translation machinery aerobic respiration|mitochondrial translation molecular_function mitochondrial nucleoid|mitochondrion|integral to membrane|mitochondrial inner membrane
YPR101W YPR101W SNT309 hom Verified 0.904223379921858 0.18293848263838 no 874 0.200412992264733 706 NA FT RNA PROCESSING NUCLEUS Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; interacts physically and genetically with Prp19p mRNA splicing, via spliceosome first spliceosomal transesterification activity Prp19 complex|U2-type catalytic step 1 spliceosome
YGR108W YGR108W CLB1 hom Verified 0.903879185193276 0.18302973370431 no 875 0.166162735347672 603 NA FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION NUCLEUS B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome G2/M transition of mitotic cell cycle|meiotic G2/MI transition|regulation of cyclin-dependent protein kinase activity|mitotic spindle organization in nucleus|positive regulation of spindle pole body separation cyclin-dependent protein kinase regulator activity cyclin-dependent protein kinase holoenzyme complex|nucleus|cytoplasm
YDR402C YDR402C DIT2 hom Verified 0.903132389698291 0.183227817764651 no 876 0.196136439441186 661 NA FT CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS N-formyltyrosine oxidase, sporulation-specific microsomal enzyme involved in the production of N,N-bisformyl dityrosine required for spore wall maturation, homologous to cytochrome P-450s ascospore wall assembly oxidoreductase activity cellular_component
YKL146W YKL146W AVT3 hom Verified 0.902981586915836 0.183267833726121 no 877 0.184378304223191 640 NA FT VACUOLAR TRANSPORT Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters amino acid export from vacuole transporter activity|L-glutamine transmembrane transporter activity|L-isoleucine transmembrane transporter activity|L-tyrosine transmembrane transporter activity fungal-type vacuole membrane|integral to membrane
YOL014W_p YOL014W YOL014W hom Uncharacterized 0.902577938312627 0.183374969883145 no 878 0.208857673564375 711 NA Putative protein of unknown function biological_process molecular_function cellular_component
YDR346C YDR346C SVF1 hom Verified 0.901530277458169 0.183653221514166 no 879 0.21182885812772 692 NA FT RESPONSE TO OXIDATIVE STRESS NUCLEUS Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis; mutant has increased aneuploidy tolerance cellular response to oxidative stress molecular_function nucleus|cytoplasm
YBL061C YBL061C SKT5 hom Verified 0.901143117674512 0.183756115071498 no 880 0.195789041517441 723 NA FT CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON Activator of Chs3p (chitin synthase III) during vegetative growth; recruits Chs3p to the bud neck via interaction with Bni4p; SKT5 has a paralog, SHC1, that arose from the whole genome duplication fungal-type cell wall chitin biosynthetic process|response to osmotic stress|cytokinesis enzyme activator activity incipient cellular bud site|cellular bud neck septin ring|cellular bud neck
YGL152C_d YGL152C YGL152C hom Dubious 0.900502141957748 0.183926542971127 no 881 0.198373186386037 633 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PEX14/YGL153W Unknown Unknown Unknown
YHR045W_p YHR045W YHR045W hom Uncharacterized 0.899326682454994 0.184239339495574 no 882 0.17937035334025 617 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS ENDOPLASMIC RETICULUM Putative protein of unknown function; possible role in iron metabolism and/or amino acid and carbohydrate metabolism; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum biological_process molecular_function endoplasmic reticulum
YNL266W_d YNL266W YNL266W hom Dubious 0.899292078036145 0.184248552943726 no 883 0.163612122845876 575 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF IST1/YNL265C Unknown Unknown Unknown
YFL010W-A YFL010W-A AUA1 hom Verified 0.896844147361023 0.184901043440794 no 884 0.197680505048165 655 NA Protein required for the negative regulation by ammonia of Gap1p, which is a general amino acid permease amino acid transport molecular_function cellular_component
YDR532C YDR532C KRE28 hom Verified 0.896166955728951 0.185081800633623 no 885 0.21446765555411 688 NA FT ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME|CYTOSKELETON KINETOCHORE Subunit of a kinetochore-microtubule binding complex with Spc105p that bridges centromeric heterochromatin and kinetochore MAPs and motors, and is also required for sister chromatid bi-orientation and kinetochore binding of SAC components biological_process molecular_function chromosome, centromeric region|condensed nuclear chromosome kinetochore|spindle pole body
YNL146W_p YNL146W YNL146W hom Uncharacterized 0.895415037080551 0.185282632655238 no 886 0.187742732341385 634 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNL146W is not an essential gene biological_process molecular_function endoplasmic reticulum
YEL040W YEL040W UTR2 hom Verified 0.893892812068689 0.185689621994742 no 887 0.177543349301686 571 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM SITE OF POLARIZED GROWTH|CYTOSKELETON Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck cell wall chitin metabolic process|fungal-type cell wall organization transferase activity, transferring glycosyl groups cellular bud neck septin ring|fungal-type cell wall
YDR382W YDR382W RPP2B hom Verified 0.893889777379406 0.1856904339173 no 888 0.169293040739651 609 NA FT TRANSLATION RIBOSOME Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm translational elongation|cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YCL034W YCL034W LSB5 hom Verified 0.892785222896068 0.185986100633776 no 889 0.208193631680236 685 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION CYTOSKELETON Protein of unknown function; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; may mediate disassembly of the Pan1 complex from the endocytic coat endocytosis|actin filament organization|actin cortical patch localization|actin cytoskeleton organization molecular_function cell cortex|cytoplasm|actin cortical patch
YLR449W YLR449W FPR4 hom Verified 0.892263387914542 0.186125886686259 no 890 0.189324121359258 669 NA FT CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones histone peptidyl-prolyl isomerization|negative regulation of histone H3-K36 methylation|regulation of transcription by chromatin organization|chromatin silencing at rDNA|nucleosome assembly peptidyl-prolyl cis-trans isomerase activity|macrolide binding chromatin|nucleus
YHR006W YHR006W STP2 hom Verified 0.89135135509047 0.186370352932329 no 891 0.162479907216585 562 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS|PLASMA MEMBRANE Transcription factor; activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes; STP2 has a paralog, STP1, that arose from the whole genome duplication positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus|cytoplasm
YGL242C_p YGL242C YGL242C hom Uncharacterized 0.891185907112279 0.186414721815507 no 892 0.209152308418061 676 NA Putative protein of unknown function; deletion mutant is viable biological_process molecular_function cellular_component
YLL054C_p YLL054C YLL054C hom Uncharacterized 0.890991360910559 0.186466902461799 no 893 0.192586647215881 618 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene biological_process sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity cellular_component
YLR279W_d YLR279W YLR279W hom Dubious 0.888145406799816 0.187231270268722 no 894 0.206779865263342 755 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGL241W YGL241W KAP114 hom Verified 0.887198585772467 0.187485996854841 no 895 0.183491710552923 587 NA FT PROTEIN LOCALIZATION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS Karyopherin, responsible for nuclear import of specific proteins; cargoes include Spt15p, Sua7p, histones H2A and H2B, and Nap1p; amino terminus shows similarity to those of other importins, particularly Cse1p; localization is primarily nuclear; function is regulated by sumoylation; protein abundance increases in response to DNA replication stress protein import into nucleus|transcription factor import into nucleus protein transporter activity integral to membrane|nucleus|cytoplasm
YER164W YER164W CHD1 hom Verified 0.886705622305649 0.187618705291293 no 896 0.210112024981293 719 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION NUCLEUS|MITOCHONDRION|CHROMOSOME HISTONE ACETYLTRANSFERASE Chromatin remodeler that regulates various aspects of transcription; acts in in conjunction with Isw1b to regulate chromatin structure and maintain chromatin integrity during transcription elongation by RNAP II by preventing trans-histone exchange over coding regions; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SLIK complexes termination of RNA polymerase I transcription|ATP-dependent chromatin remodeling|nucleosome positioning|negative regulation of histone H3-K14 acetylation|termination of RNA polymerase II transcription|regulation of transcription by chromatin organization|regulation of transcriptional start site selection at RNA polymerase II promoter|nucleosome mobilization|Unknown|transcription elongation from RNA polymerase II promoter chromatin DNA binding|DNA-dependent ATPase activity|methylated histone residue binding|DNA binding|rDNA binding nuclear chromatin|SLIK (SAGA-like) complex|mitochondrion|SAGA complex|nucleolar chromatin
YER120W YER120W SCS2 hom Verified 0.88661406768309 0.187643358680602 no 897 0.183008689522237 654 NA FT PROTEIN LOCALIZATION|LIPID METABOLISM|GENE SILENCING ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH Integral ER membrane protein, regulates phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PI4P levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; interacts with FFAT motif of Opi1p; involved in telomeric silencing; null shows inositol auxotrophy above 34 deg C; VAP homolog; SCS2 has a paralog, SCS22, that arose from the whole genome duplication endoplasmic reticulum inheritance|regulation of intracellular lipid transport|negative regulation of transcription factor import into nucleus|phospholipid biosynthetic process|chromatin silencing at telomere phosphatidylinositol binding|FFAT motif binding nuclear membrane|integral to endoplasmic reticulum membrane|nuclear envelope|endoplasmic reticulum|cellular bud tip
YER050C YER050C RSM18 hom Verified 0.886222967844588 0.187748694701552 no 898 0.221458793585062 741 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YJL068C YJL068C YJL068C hom Verified 0.885210488332035 0.188021558280819 no 899 0.16903658151479 580 NA Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D formaldehyde catabolic process S-formylglutathione hydrolase activity cytosol
YOR199W_d YOR199W YOR199W hom Dubious 0.884310181755782 0.188264396724114 no 900 0.212224636111294 700 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGL021W YGL021W ALK1 hom Verified 0.884274490576583 0.188274027642379 no 901 0.191531510319922 625 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; ALK1 has a paralog, ALK2, that arose from the whole genome duplication; similar to mammalian haspins mitosis|protein phosphorylation protein serine/threonine kinase activity|protein kinase activity cellular_component
YDR445C_d YDR445C YDR445C hom Dubious 0.883315664446503 0.18853287132668 no 902 0.211589171006454 694 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOR354C YOR354C MSC6 hom Verified 0.882674638315981 0.1887060443909 no 903 0.199403762706878 664 NA FT CELL CYCLE MITOCHONDRION Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies reciprocal meiotic recombination molecular_function mitochondrion
YAL054C YAL054C ACS1 hom Verified 0.882522037303647 0.188747283963954 no 904 0.167005440636095 562 NA FT KETONE METABOLISM|CHROMATIN ORGANIZATION|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetylation; expressed during growth on nonfermentable carbon sources and under aerobic conditions acetate fermentation|histone acetylation|acetyl-CoA biosynthetic process acetate-CoA ligase activity|acid-ammonia (or amide) ligase activity cytosol|mitochondrion|integral to membrane
YKR092C YKR092C SRP40 hom Verified 0.882494122458342 0.18875482839626 no 905 0.183097330059705 679 NA FT NUCLEUS Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140 nucleocytoplasmic transport molecular_function nucleolus
YDL237W YDL237W AIM6 hom Verified 0.882203504136944 0.188833383673669 no 906 0.193317535234023 636 NA Putative protein of unknown function, required for respiratory growth; YDL237W is not an essential gene biological_process molecular_function cellular_component
YLR456W_p YLR456W YLR456W hom Uncharacterized 0.882036109092432 0.188878640356444 no 907 0.158937491107385 612 NA FT OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM NUCLEUS Putative pyridoxal 5'-phosphate synthase; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2; YLR456W has a paralog, YPR172W, that arose from the whole genome duplication biological_process molecular_function cellular_component
YPR114W_p YPR114W YPR114W hom Uncharacterized 0.881870574613533 0.188923400590957 no 908 0.198272992372305 696 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Putative protein of unknown function biological_process molecular_function integral to membrane|endoplasmic reticulum
YML094W YML094W GIM5 hom Verified 0.881837090932644 0.188932455314483 no 909 0.18544767786569 665 NA FT PROTEIN COMPLEX ORG/BIOGENESIS Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it tubulin complex assembly tubulin binding prefoldin complex|cytoplasm
YOL037C_d YOL037C YOL037C hom Dubious 0.881394542340474 0.189052155302462 no 910 0.201447835452296 673 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOL036W Unknown Unknown Unknown
YHR109W YHR109W CTM1 hom Verified 0.88127199733327 0.189085309378572 no 911 0.162028840127784 556 NA Cytochrome c lysine methyltransferase, trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol; not required for normal respiratory growth peptidyl-lysine methylation [cytochrome c]-lysine N-methyltransferase activity cytosol
YPR072W YPR072W NOT5 hom Verified 0.880972753398406 0.189166283711111 no 912 0.189867436536874 639 NA FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation deadenylation-independent decapping of nuclear-transcribed mRNA|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|nuclear-transcribed mRNA poly(A) tail shortening|transcription elongation from RNA polymerase II promoter|protein ubiquitination ubiquitin-protein ligase activity CCR4-NOT core complex|cytoplasm
YHL035C YHL035C VMR1 hom Verified 0.880572135709455 0.189274722840289 no 913 0.196683273306469 672 NA FT NUCLEOTIDE METABOLISM MITOCHONDRION Vacuolar membrane protein involved in multiple drug resistance and metal sensitivity; ATP-binding cassette (ABC) family member involved in drug transport; potential Cdc28p substrate; induced under respiratory conditions transport|response to drug|response to metal ion|drug transport ATPase activity, coupled to transmembrane movement of substances fungal-type vacuole membrane|mitochondrion|integral to membrane|ribosome
YDL083C YDL083C RPS16B hom Verified 0.880293249335073 0.189350234346261 no 914 0.217213775520634 717 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16B has a paralog, RPS16A, that arose from the whole genome duplication cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit
YDR266C YDR266C HEL2 hom Verified 0.879809178064136 0.189481345903804 no 915 0.195920778357087 628 NA RING finger ubiquitin ligase (E3); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; computational analysis suggests a role as a transcription factor biological_process molecular_function ribosome|cytoplasm
YDR036C YDR036C EHD3 hom Verified 0.878412877293806 0.18985984930563 no 916 0.168157087413691 563 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION 3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis fatty acid beta-oxidation|biological_process 3-hydroxyisobutyryl-CoA hydrolase activity mitochondrion
YDR049W YDR049W VMS1 hom Verified 0.878377137314507 0.189869543648469 no 917 0.180156094485028 631 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans ER-associated protein catabolic process|mitochondria-associated protein catabolic process|nucleus-associated proteasomal ubiquitin-dependent protein catabolic process molecular_function cytosol|mitochondrion|endoplasmic reticulum membrane|Cdc48p-Npl4p-Vms1p AAA ATPase complex|cytoplasm
YJR096W YJR096W YJR096W hom Verified 0.878042097479106 0.189960436816218 no 918 0.181714306847167 617 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS NUCLEUS Putative xylose and arabinose reductase; member of the aldo-keto reductase (AKR) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS cellular response to oxidative stress|D-xylose catabolic process|arabinose catabolic process alditol:NADP+ 1-oxidoreductase activity|aldo-keto reductase (NADP) activity nucleus|cytoplasm
YPL092W YPL092W SSU1 hom Verified 0.877729543899869 0.190045253784192 no 919 0.193087131385553 601 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein sulfite transport sulfite transmembrane transporter activity integral to membrane|plasma membrane
YOR243C YOR243C PUS7 hom Verified 0.877687694597924 0.190056612102585 no 920 0.212524898972358 693 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Pseudouridine synthase, catalyzes pseudouridylation at positions 35 and 56 in U2 snRNA, position 50 in 5S rRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); conserved in archaea, vertebrates, and some bacteria snRNA pseudouridine synthesis|tRNA pseudouridine synthesis|enzyme-directed rRNA pseudouridine synthesis pseudouridine synthase activity nucleus
YBL072C YBL072C RPS8A hom Verified 0.877560883250812 0.190091032515829 no 921 0.177594651058013 658 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S8, no bacterial homolog; RPS8A has a paralog, RPS8B, that arose from the whole genome duplication cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit|90S preribosome
YMR186W YMR186W HSC82 hom Verified 0.87732652023366 0.190154655768401 no 922 0.192099940402943 627 NA FT PROTEIN COMPLEX ORG/BIOGENESIS MITOCHONDRION Cytoplasmic chaperone of the Hsp90 family; redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock; contains two acid-rich unstructured regions that promote the solubility of chaperone-substrate complexes; HSC82 has a paralog, HSP82, that arose from the whole genome duplication protein folding|proteasome assembly|protein refolding|telomere maintenance|'de novo' protein folding|box C/D snoRNP assembly|response to stress unfolded protein binding|ATPase activity, coupled|ATPase activity mitochondrion|plasma membrane|cytoplasm
YDR195W YDR195W REF2 hom Verified 0.875705377200804 0.190595110684268 no 923 0.215495826938251 723 NA FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS RNA-binding protein involved in the cleavage step of mRNA 3'-end formation prior to polyadenylation, and in snoRNA maturation; part of holo-CPF subcomplex APT, which associates with 3'-ends of snoRNA- and mRNA-encoding genes mRNA 3'-end processing|termination of RNA polymerase II transcription, poly(A)-coupled|snoRNA 3'-end processing|Unknown chromatin binding|RNA binding mRNA cleavage and polyadenylation specificity factor complex|nucleus
YIR018C-A_p YIR018C-A YIR018C-A hom Uncharacterized 0.875053637737015 0.190772360780489 no 924 0.180393811868307 634 NA Putative protein of unknown function; identified by expression profiling and mass spectrometry biological_process molecular_function cellular_component
YER052C YER052C HOM3 hom Verified 0.874512959063815 0.190919483005949 no 925 0.194266994844868 687 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis threonine biosynthetic process|methionine biosynthetic process|homoserine biosynthetic process aspartate kinase activity cytoplasm
YKR032W_d YKR032W YKR032W hom Dubious 0.874112677244905 0.191028447148375 no 926 0.171402857984472 599 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR450W YDR450W RPS18A hom Verified 0.874014666053653 0.191055133425936 no 927 0.204455392996642 683 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION MITOCHONDRION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18A has a paralog, RPS18B, that arose from the whole genome duplication; protein increases in abundance and relocalizes from cytoplasm to nuclear foci upon DNA replication stress endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|cytoplasmic translation|rRNA export from nucleus structural constituent of ribosome cytosolic small ribosomal subunit|mitochondrion
YLR320W YLR320W MMS22 hom Verified 0.87224211915552 0.1915381531829 no 928 0.192456226157396 679 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS UBIQUITIN LIGASE COMPLEX Subunit of an E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of the replication fork, such as the fork-pausing complex and leading strand polymerase, preventing fork collapse and promoting efficient recovery during replication stress; required for accurate meiotic chromosome segregation replication fork processing|double-strand break repair|recombinational repair|meiotic sister chromatid segregation|response to DNA damage stimulus molecular_function Cul8-RING ubiquitin ligase complex|nucleus
YHR125W_d YHR125W YHR125W hom Dubious 0.87122949380648 0.191814429466131 no 929 0.203700367483378 745 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YJL183W YJL183W MNN11 hom Verified 0.869946140371379 0.192164919292064 no 930 0.224903303548683 756 NA FT CARBOHYDRATE METABOLISM GOLGI APPARATUS Subunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p protein glycosylation alpha-1,6-mannosyltransferase activity alpha-1,6-mannosyltransferase complex
YHL042W_p YHL042W YHL042W hom Uncharacterized 0.869711508689505 0.192229040639878 no 931 0.173412789029605 576 NA Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins biological_process molecular_function cellular_component
YDR003W YDR003W RCR2 hom Verified 0.869508170956584 0.192284620401489 no 932 0.17090943415746 577 NA FT VESICLE-MEDIATED TRANSPORT Vacuolar protein; presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR2 has a paralog, RCR1, that arose from the whole genome duplication vesicle-mediated transport molecular_function vesicle|integral to membrane|fungal-type vacuole|cytoplasm
YOR255W YOR255W OSW1 hom Verified 0.867047189913936 0.192958077090719 no 933 0.188861134896569 650 NA FT CELL WALL ORG/BIOGENESIS Protein involved in sporulation; required for the construction of the outer spore wall layers; required for proper localization of Spo14p ascospore wall assembly|ascospore formation molecular_function prospore membrane
YHR203C YHR203C RPS4B hom Verified 0.866679822147198 0.193058732081047 no 934 0.223278235352232 738 NA FT TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4B has a paralog, RPS4A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic small ribosomal subunit|90S preribosome
YNL304W YNL304W YPT11 hom Verified 0.866667482140103 0.193062113672526 no 935 0.200836685321653 654 NA FT SIGNALING|MITOCHONDRION ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH Rab family GTPase that interacts with the C-terminal tail domain of Myo2p; mediates distribution of mitochondria and endoplasmic reticuli to daughter cells mitochondrion inheritance|endoplasmic reticulum inheritance|Golgi inheritance|Golgi localization GTPase activity incipient cellular bud site|endoplasmic reticulum|cellular bud neck|cellular bud tip
YGL177W_d YGL177W YGL177W hom Dubious 0.866507539097037 0.193105946905824 no 936 0.226115668648255 766 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR335W YDR335W MSN5 hom Verified 0.865791528823901 0.193302247763147 no 937 0.212380714610373 731 NA FT PROTEIN LOCALIZATION|RNA LOCALIZATION NUCLEUS Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm tRNA re-export from nucleus|protein export from nucleus protein binding|importin-alpha export receptor activity integral to membrane|nucleus|cytoplasm
YDR251W YDR251W PAM1 hom Verified 0.865700106476324 0.193327320811737 no 938 0.186417634578885 616 NA FT OXIDATION-REDUCTION PROCESS SITE OF POLARIZED GROWTH Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype pseudohyphal growth molecular_function cellular bud|cellular bud neck
YDL204W YDL204W RTN2 hom Verified 0.865558329073015 0.193366207918134 no 939 0.215628930080413 741 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Reticulon protein; stabilizes membrane curvature; involved in nuclear pore assembly and maintenance of tubular ER morphology; interacts with exocyst subunit Sec6p, Yip3p, and Sbh1p; much less abundant than Rtn1p; rtn1 rtn2 yop1 triple mutant lacks tubular ER; member of RTNLA (reticulon-like A) subfamily; protein increases in abundance and relocalizes to plasma membrane upon DNA replication stress; RTN2 has a paralog, RTN1, that arose from the whole genome duplication endoplasmic reticulum tubular network organization|endoplasmic reticulum tubular network maintenance molecular_function endoplasmic reticulum|cortical endoplasmic reticulum|endoplasmic reticulum tubular network
YJR097W YJR097W JJJ3 hom Verified 0.865457702414783 0.19339381097766 no 940 0.203661591252306 693 NA FT NUCLEUS Protein of unknown function, contains a CSL Zn finger and a DnaJ-domain; involved in diphthamide biosynthesis; ortholog human Dph4 peptidyl-diphthamide biosynthetic process from peptidyl-histidine ferrous iron binding nucleus|cytoplasm
YCR065W YCR065W HCM1 hom Verified 0.865041164297982 0.193508097785637 no 941 0.194662950934338 704 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|RESPONSE TO OXIDATIVE STRESS NUCLEUS|CHROMOSOME Forkhead transcription factor that drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere maintenance role positive regulation of transcription involved in S-phase of mitotic cell cycle|cellular response to oxidative stress|mitochondrion organization|spindle pole body organization|positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding nuclear chromatin|nucleus|cytoplasm
YEL023C_p YEL023C YEL023C hom Uncharacterized 0.865036141837344 0.193509476064488 no 942 0.196134996857182 663 NA Putative protein of unknown function; expression is increased greatly during sporulation; YEL023C is not an essential gene biological_process molecular_function cellular_component
YOL075C_p YOL075C YOL075C hom Uncharacterized 0.86247416043093 0.194213323162169 no 943 0.152576468721827 493 NA FT NUCLEOTIDE METABOLISM Putative ABC transporter transport ATPase activity, coupled to transmembrane movement of substances integral to membrane|membrane
YJL196C YJL196C ELO1 hom Verified 0.860572844175049 0.194736673837664 no 944 0.165161388571464 553 NA FT KETONE METABOLISM|LIPID METABOLISM Elongase I, medium-chain acyl elongase; catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids; ELO1 has a paralog, FEN1, that arose from the whole genome duplication fatty acid elongation, unsaturated fatty acid fatty acid elongase activity integral to membrane|membrane
YNL224C YNL224C SQS1 hom Verified 0.86022871028481 0.19483149072352 no 945 0.187169830838054 680 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEOTIDE METABOLISM NUCLEUS Protein that stimulates the ATPase and helicase activities of Prp43p; acts with Prp43p to stimulate 18s rRNA maturation by Nob1p; overexpression antagonizes the suppression of splicing defects by spp382 mutants; component of pre-ribosomal particles; relocalizes from nucleus to nucleolus upon DNA replication stress positive regulation of helicase activity|positive regulation of ATPase activity|mRNA splicing, via spliceosome|maturation of SSU-rRNA|rRNA processing molecular_function preribosome, small subunit precursor|nucleus|preribosome, large subunit precursor|90S preribosome|cytoplasm
YDL214C YDL214C PRR2 hom Verified 0.860037789531932 0.194884105936503 no 946 0.187270597753574 621 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN PHOSPHORYLATION NUCLEUS Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor; mutant has increased aneuploidy tolerance negative regulation of transcription from RNA polymerase II promoter by pheromones|negative regulation of conjugation with cellular fusion|protein phosphorylation protein kinase activity|receptor signaling protein serine/threonine kinase activity nucleus
YIL136W YIL136W OM45 hom Verified 0.859510501137364 0.195029464466387 no 947 0.198886034487759 647 NA FT MITOCHONDRION Mitochondrial outer membrane protein of unknown function; major constituent of the outer membrane, located on the outer (cytosolic) face; protein abundance increases in response to DNA replication stress biological_process molecular_function mitochondrial outer membrane|mitochondrion|integral to mitochondrial outer membrane
YDR071C YDR071C PAA1 hom Verified 0.858792575881228 0.195227482130944 no 948 0.205960137591839 708 NA FT CHROMATIN ORGANIZATION Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication chromatin organization diamine N-acetyltransferase activity|aralkylamine N-acetyltransferase activity cytoplasm
YGR244C YGR244C LSC2 hom Verified 0.857847514133357 0.195488334620696 no 949 0.197212087541685 671 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Beta subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate tricarboxylic acid cycle|succinyl-CoA metabolic process succinate-CoA ligase (ADP-forming) activity mitochondrion
YLR171W_d YLR171W YLR171W hom Dubious 0.857415581788332 0.195607625454853 no 950 0.206754334414884 741 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPL065W YPL065W VPS28 hom Verified 0.855789034444058 0.196057240847304 no 951 0.219039353291796 780 NA FF|FT PROTEIN LOCALIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p protein targeting to membrane|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein targeting to vacuole protein complex binding endosome|ESCRT I complex
YDR452W YDR452W PPN1 hom Verified 0.85471047398484 0.196355725317582 no 952 0.242840098685309 734 NA FT NUCLEUS Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress polyphosphate catabolic process|polyphosphate metabolic process endopolyphosphatase activity|exopolyphosphatase activity fungal-type vacuole membrane|nucleus
YDR065W YDR065W RRG1 hom Verified 0.854536424284303 0.19640391821917 no 953 0.193240703477164 688 NA FT ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS MITOCHONDRION Protein of unknown function, required for vacuolar acidification and mitochondrial genome maintenance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies mitochondrial genome maintenance|vacuolar acidification molecular_function mitochondrion
YAR023C_p YAR023C YAR023C hom Uncharacterized 0.854472925724521 0.196421502222236 no 954 0.195963214121421 682 NA Putative integral membrane protein, member of DUP240 gene family biological_process molecular_function cellular_component
YHR049C-A_d YHR049C-A YHR049C-A hom Dubious 0.853766624522543 0.196617155273538 no 955 0.180270330880823 619 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOR283W YOR283W YOR283W hom Verified 0.853050451801899 0.196815663345144 no 956 0.190645280834085 645 NA FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Phosphatase with a broad substrate specificity and some similarity to GPM1/YKL152C, a phosphoglycerate mutase; YOR283W is not an essential gene dephosphorylation phosphatase activity nucleus|cytoplasm
YNL138W YNL138W SRV2 hom Verified 0.85294318738227 0.196845405240714 no 957 0.260174028562905 891 NA FT SIGNALING|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON CAP (cyclase-associated protein) subunit of adenylyl cyclase complex; N-terminus binds adenylyl cyclase and facilitates activation by RAS; C-terminus binds ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis cytoskeleton organization|Ras protein signal transduction cytoskeletal protein binding|adenylate cyclase binding mating projection tip|actin cortical patch
YJR087W_d YJR087W YJR087W hom Dubious 0.851570254146044 0.19722632755874 no 958 0.189645491545008 682 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified genes STE18 and ECM2 Unknown Unknown Unknown
YOL016C YOL016C CMK2 hom Verified 0.851359560472671 0.197284824268881 no 959 0.20471242903492 662 NA FT SIGNALING|PROTEIN PHOSPHORYLATION Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK2 has a paralog, CMK1, that arose from the whole genome duplication signal transduction|protein phosphorylation protein kinase activity|calmodulin-dependent protein kinase activity cytoplasm
YNL230C YNL230C ELA1 hom Verified 0.850668821821691 0.197476673616885 no 960 0.208046732775332 750 NA FT PROTEOLYSIS NUCLEUS UBIQUITIN LIGASE COMPLEX Elongin A; F-box protein that forms a heterodimer with Elc1p and is required for ubiquitin-dependent degradation of the RNA Polymerase II subunit Rpo21p; subunit of the Elongin-Cullin-Socs (ECS) ligase complex protein ubiquitination involved in ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity elongin complex|Cul3-RING ubiquitin ligase complex
YJR049C YJR049C UTR1 hom Verified 0.850664926260139 0.197477755910214 no 961 0.22445330231089 768 NA FF|FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|COFACTOR METABOLISM NUCLEUS ATP-NADH kinase; phosphorylates both NAD and NADH; active as a hexamer; enhances the activity of ferric reductase (Fre1p); UTR1 has a paralog, YEF1, that arose from the whole genome duplication cellular iron ion homeostasis|NADP biosynthetic process NAD+ kinase activity|NADH kinase activity nucleus|cytoplasm
YOR012W_p YOR012W YOR012W hom Uncharacterized 0.850493101695541 0.197525497032072 no 962 0.147416401052732 497 NA Putative protein of unknown function biological_process molecular_function cellular_component
YPL120W YPL120W VPS30 hom Verified 0.850312443801449 0.197575700001826 no 963 0.205269025497591 728 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy and Complex II is required for vacuolar protein sorting; required for overflow degradation of misfolded proteins when ERAD is saturated; ortholog of the higher eukaryotic gene Beclin 1 phosphatidylinositol biosynthetic process|piecemeal microautophagy of nucleus|ER-associated protein catabolic process|peroxisome degradation|retrograde transport, endosome to Golgi|macroautophagy|CVT pathway|late endosome to vacuole transport 1-phosphatidylinositol-3-kinase activity phosphatidylinositol 3-kinase complex I|phosphatidylinositol 3-kinase complex II|extrinsic to membrane|cytoplasm
YDR105C YDR105C TMS1 hom Verified 0.848914195885668 0.197964519527086 no 964 0.206716656135106 699 NA Vacuolar membrane protein of unknown function that is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p, a protein involved in multidrug resistance biological_process molecular_function fungal-type vacuole membrane|integral to membrane|membrane
YKL184W YKL184W SPE1 hom Verified 0.848875565808954 0.197975268190035 no 965 0.197761383437944 652 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation pantothenate biosynthetic process|putrescine biosynthetic process ornithine decarboxylase activity cytoplasm
YKL103C YKL103C APE1 hom Verified 0.848845839132525 0.197983539757767 no 966 0.166579329719363 584 NA Vacuolar aminopeptidase yscI; zinc metalloproteinase that belongs to the peptidase family M18; often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway; protein increases in abundance and relative distribution to cytoplasmic foci increases upon DNA replication stress vacuolar protein catabolic process metalloaminopeptidase activity fungal-type vacuole
YGR012W YGR012W YGR012W hom Verified 0.847817735656148 0.198269742126218 no 967 0.183030637464894 599 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Putative cysteine synthase, localized to the mitochondrial outer membrane cysteine biosynthetic process cysteine synthase activity mitochondrial outer membrane|mitochondrion
YBR176W YBR176W ECM31 hom Verified 0.84768856312332 0.198305718690705 no 968 0.207071365736907 619 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM MITOCHONDRION Ketopantoate hydroxymethyltransferase, required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate pantothenate biosynthetic process 3-methyl-2-oxobutanoate hydroxymethyltransferase activity mitochondrion
YGR262C YGR262C BUD32 hom Verified 0.846878335794042 0.19853146948233 no 969 0.236424760749022 747 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|LIPID METABOLISM|CELL DIVISION|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION NUCLEUS|CHROMOSOME Protein kinase, component of the EKC/KEOPS complex with Kae1p, Cgi121p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription threonylcarbamoyladenosine metabolic process|protein phosphorylation|telomere maintenance|cellular bud site selection|positive regulation of transcription from RNA polymerase II promoter protein serine/threonine kinase activity EKC/KEOPS complex|nucleus|cytoplasm
YGR240C YGR240C PFK1 hom Verified 0.845350142967811 0.198957686199666 no 970 0.233237414273267 818 NA FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Alpha subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes proton transport|glycolysis 6-phosphofructokinase activity mitochondrion|6-phosphofructokinase complex|cytoplasm
YPR005C YPR005C HAL1 hom Verified 0.845223552014763 0.198993017440625 no 971 0.20222979143832 714 NA FT TRANSCRIPTION FROM RNA POL II Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p response to salt stress|positive regulation of transcription from RNA polymerase II promoter molecular_function cytoplasm
YOR334W YOR334W MRS2 hom Verified 0.84461101139589 0.199164029506145 no 972 0.185632236955231 644 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Mitochondrial inner membrane Mg(2+) channel, required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns mitochondrial magnesium ion transport magnesium ion transmembrane transporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YIR042C_p YIR042C YIR042C hom Uncharacterized 0.844148415612797 0.199293237898822 no 973 0.185396125407707 604 NA Putative protein of unknown function; YIR042C is a non-essential gene biological_process molecular_function cellular_component
YDL200C YDL200C MGT1 hom Verified 0.842723935084127 0.199691428837795 no 974 0.221422195707008 725 NA FT RESPONSE TO DNA DAMAGE NUCLEUS DNA repair methyltransferase (6-O-methylguanine-DNA methylase) involved in protection against DNA alkylation damage DNA dealkylation involved in DNA repair methylated-DNA-[protein]-cysteine S-methyltransferase activity nucleus
YBR249C YBR249C ARO4 hom Verified 0.841163208808578 0.200128254206477 no 975 0.19609941711212 675 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan; relative distribution to the nucleus increases upon DNA replication stress aromatic amino acid family biosynthetic process 3-deoxy-7-phosphoheptulonate synthase activity nucleus|cytoplasm
YDR203W_d YDR203W YDR203W hom Dubious 0.840842179390204 0.200218177001109 no 976 0.240552878626493 846 NA FF Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOR112W YOR112W CEX1 hom Verified 0.840342616914761 0.200358156551046 no 977 0.202583235936078 685 NA FT RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS Cytoplasmic component of the nuclear aminoacylation-dependent tRNA export pathway; interacts with nuclear pore component Nup116p; copurifies with tRNA export receptors Los1p and Msn5p, as well as eIF-1a and the RAN GTPase Gsp1p tRNA export from nucleus tRNA binding nuclear pore|cytoplasm
YHL047C YHL047C ARN2 hom Verified 0.840202183407115 0.200397517206895 no 978 0.194159452814258 660 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS|COFACTOR METABOLISM PLASMA MEMBRANE Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C cellular iron ion homeostasis|siderophore transport|siderophore metabolic process siderophore transmembrane transporter activity endosome|integral to membrane|cytoplasmic membrane-bounded vesicle|plasma membrane
YMR256C YMR256C COX7 hom Verified 0.839992289369381 0.200456354895022 no 979 0.229357449937518 766 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain mitochondrial electron transport, cytochrome c to oxygen cytochrome-c oxidase activity mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YML079W_p YML079W YML079W hom Uncharacterized 0.839649024368766 0.20055260161004 no 980 0.205507970194168 649 NA FT NUCLEUS Non-essential protein of unknown function with structural resemblance to plant storage and ligand binding proteins (canavalin, glycinin, auxin binding protein) and to some enzymes (epimerase, germin); localizes to the nucleus and cytoplasm biological_process molecular_function nucleus|cytoplasm
YER128W YER128W VFA1 hom Verified 0.839638838183773 0.200555458098019 no 981 0.205884527172481 721 NA FT VACUOLAR TRANSPORT Protein that interacts with Vps4p and has a role in vacuolar sorting; localizes to endosomes in a Vps4-dependent manner; overexpression causes canavanine sensitivity and confers a partial class D vacuole morphology vacuolar transport molecular_function endosome|cytoplasm
YDR174W YDR174W HMO1 hom Verified 0.839529155047161 0.200586217830748 no 982 0.20133517191741 733 NA FT TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase regulation of transcription from RNA polymerase I promoter|regulation of transcription by chromatin organization|regulation of ribosomal protein gene transcription from RNA polymerase II promoter double-stranded DNA binding|four-way junction DNA binding|DNA binding, bending nuclear chromatin|nucleolus|cytoplasm
YIL159W YIL159W BNR1 hom Verified 0.839472380247514 0.200602140968506 no 983 0.195485741407666 672 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNI1 barbed-end actin filament capping|actin filament bundle assembly|formin-nucleated actin cable assembly profilin binding cellular bud neck
YLR357W YLR357W RSC2 hom Verified 0.839282199455821 0.200655484861679 no 984 0.207331595660437 686 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS RSC COMPLEX Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenance ATP-dependent chromatin remodeling|chromosome segregation|nucleosome disassembly|plasmid maintenance|sister chromatid cohesion|double-strand break repair via nonhomologous end joining|transcription elongation from RNA polymerase II promoter|double-strand break repair via homologous recombination DNA translocase activity RSC complex
YBL021C YBL021C HAP3 hom Verified 0.837705417868467 0.201098084929566 no 985 0.209644857191075 658 NA FT TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding carbon catabolite activation of transcription from RNA polymerase II promoter|regulation of cellular respiration RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription CCAAT-binding factor complex
YHR171W YHR171W ATG7 hom Verified 0.837519875542776 0.201150204839295 no 986 0.250938164167252 850 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS MITOCHONDRION Autophagy-related protein and dual specificity member of the E1 family of ubiquitin-activating enzymes; mediates the conjugation of Atg12p with Atg5p and Atg8p with phosphatidylethanolamine, required steps in autophagosome formation C-terminal protein lipidation|protein modification by small protein conjugation|piecemeal microautophagy of nucleus|mitochondrion degradation|macroautophagy|CVT pathway APG8 activating enzyme activity|APG12 activating enzyme activity cytosol|mitochondrion|membrane|pre-autophagosomal structure
YOR026W YOR026W BUB3 hom Verified 0.836110269076687 0.201546435909505 no 987 0.199571265668266 714 NA FT CELL CYCLE NUCLEUS|CHROMOSOME KINETOCHORE Kinetochore checkpoint WD40 repeat protein that localizes to kinetochores during prophase and metaphase, delays anaphase in the presence of unattached kinetochores; forms complexes with Mad1p-Bub1p and with Cdc20p, binds Mad2p and Mad3p mitotic cell cycle G2/M transition decatenation checkpoint|mitotic cell cycle spindle assembly checkpoint ubiquitin binding mitotic checkpoint complex|condensed nuclear chromosome kinetochore
YKL084W YKL084W HOT13 hom Verified 0.835823960852687 0.20162697236087 no 988 0.202357629238902 695 NA FT PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Zinc-binding mitochondrial intermembrane space (IMS) protein involved in a disulfide relay system for IMS import of cysteine-containing proteins; binds Mia40p and stimulates its Erv1p-dependent oxidation, probably by sequestering zinc protein import into mitochondrial intermembrane space zinc ion binding mitochondrial intermembrane space
YHR037W YHR037W PUT2 hom Verified 0.835804550574032 0.201632433030827 no 989 0.219742201632475 748 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION Delta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism glutamate biosynthetic process|proline catabolic process to glutamate 1-pyrroline-5-carboxylate dehydrogenase activity mitochondrion|mitochondrial matrix
YHR194W YHR194W MDM31 hom Verified 0.834972504658953 0.201866594774237 no 990 0.227716607275412 768 NA FT ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS NUCLEUS|MITOCHONDRION Mitochondrial protein that may have a role in phospholipid metabolism; inner membrane protein with similarity to Mdm32p; required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MMM2, MDM10, MDM12, and MDM34 mitochondrion inheritance|cellular ion homeostasis|mitochondrion organization|Unknown molecular_function mitochondrial inner membrane|nucleus
YDL202W YDL202W MRPL11 hom Verified 0.834353539289265 0.202040895062677 no 991 0.207084071377342 708 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YLR350W YLR350W ORM2 hom Verified 0.832963843478949 0.202432560577124 no 992 0.210842843307012 759 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Evolutionarily conserved protein, similar to Orm1p; required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control; protein abundance increases in response to DNA replication stress cellular sphingolipid homeostasis|negative regulation of sphingolipid biosynthetic process|response to unfolded protein molecular_function integral to membrane|endoplasmic reticulum|SPOTS complex
YIL015W YIL015W BAR1 hom Verified 0.832682079622973 0.202512026934395 no 993 0.205058869973854 690 NA FT SIGNALING|PROTEOLYSIS Aspartyl protease secreted into the periplasmic space of mating type a cells, helps cells find mating partners, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|peptide catabolic process aspartic-type endopeptidase activity cell wall-bounded periplasmic space
YAL030W YAL030W SNC1 hom Verified 0.831684907536323 0.202793410890947 no 994 0.185047264529947 675 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|GOLGI APPARATUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; proposed to be involved in endocytosis; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC1 has a paralog, SNC2, that arose from the whole genome duplication endocytosis|exocytosis|Golgi to plasma membrane transport|vesicle fusion SNAP receptor activity SNARE complex|trans-Golgi network|endosome|transport vesicle membrane|plasma membrane|cellular bud neck
YBR125C YBR125C PTC4 hom Verified 0.831610393741284 0.202814446713828 no 995 0.174937383182847 592 NA Cytoplasmic type 2C protein phosphatase (PP2C); identified as a high-copy number suppressor of cnb1 mpk1 synthetic lethality; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity protein dephosphorylation protein serine/threonine phosphatase activity cytoplasm
YCL040W YCL040W GLK1 hom Verified 0.831165083840421 0.202940188328516 no 996 0.207687262007766 681 NA FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Glucokinase; catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources; GLK1 has a paralog, EMI2, that arose from the whole genome duplication glucose import|mannose metabolic process|glycolysis|glucose metabolic process glucokinase activity cytosol|plasma membrane
YOL007C YOL007C CSI2 hom Verified 0.830933345905622 0.203005642302551 no 997 0.195295772956113 659 NA FT SITE OF POLARIZED GROWTH Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene biological_process molecular_function fungal-type vacuole|cellular bud neck
YML071C YML071C COG8 hom Verified 0.830605217720636 0.203098343093559 no 998 0.334940504118756 1143 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments intra-Golgi vesicle-mediated transport|CVT pathway molecular_function Golgi transport complex
YOR058C YOR058C ASE1 hom Verified 0.829584174305567 0.203386963741936 no 999 0.169217272792866 604 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION NUCLEUS|CYTOSKELETON Mitotic spindle midzone localized protein; microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate; relative distribution to microtubules decreases upon DNA replication stress cytokinesis, completion of separation|mitotic anaphase B|microtubule bundle formation|spindle pole body separation|spindle midzone assembly|mitotic spindle stabilization|mitotic spindle elongation microtubule binding spindle midzone|nuclear microtubule|spindle
YGL163C YGL163C RAD54 hom Verified 0.828441273759249 0.203710320119267 no 1000 0.272329913722229 903 NA FF|FT CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS DNA-dependent ATPase that stimulates strand exchange; modifies the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family; forms nuclear foci upon DNA replication stress positive regulation of endodeoxyribonuclease activity|DNA geometric change|heteroduplex formation|telomere maintenance via recombination|double-strand break repair via synthesis-dependent strand annealing|chromatin remodeling|double-strand break repair via single-strand annealing DNA-dependent ATPase activity|DNA translocase activity nucleus
YPL213W YPL213W LEA1 hom Verified 0.828082317207616 0.203811941506703 no 1001 0.203012389880845 740 NA FT RNA PROCESSING NUCLEUS Component of U2 snRNP; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; putative homolog of human U2A' snRNP protein mRNA splicing, via spliceosome molecular_function U2 snRNP|U2-type prespliceosome|cytoplasm
YJL110C YJL110C GZF3 hom Verified 0.827911332944671 0.203860358149689 no 1002 0.21022464968182 690 NA FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS NUCLEUS GATA zinc finger protein; negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p; GZF3 has a paralog, DAL80, that arose from the whole genome duplication maintenance of protein location in nucleus|nitrogen catabolite repression of transcription|negative regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding RNA polymerase II transcription factor activity|sequence-specific DNA binding nucleus
YIL166C_p YIL166C YIL166C hom Uncharacterized 0.82764232097349 0.203936546617438 no 1003 0.204971647576668 672 NA Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; YIL166C is a non-essential gene transport transporter activity integral to membrane|membrane
YOL029C_p YOL029C YOL029C hom Uncharacterized 0.827439332035293 0.203994047542885 no 1004 0.191886522501624 667 NA Putative protein of unknown function; identified as interacting with Hsc82p and Hsp82p in high-throughput two-hybrid screens biological_process molecular_function cellular_component
YLL045C YLL045C RPL8B hom Verified 0.827244071433573 0.204049368367115 no 1005 0.18763308689087 639 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal 60S subunit protein L8B; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8B has a paralog, RPL8A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YBL028C YBL028C YBL028C hom Verified 0.82595029821916 0.204416143224461 no 1006 0.227577595644588 733 NA FT NUCLEUS Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis biological_process molecular_function ribosome|nucleolus|nucleus|preribosome, large subunit precursor
YMR141C_d YMR141C YMR141C hom Dubious 0.82489505938902 0.204715585766311 no 1007 0.208337038380018 709 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR085C YLR085C ARP6 hom Verified 0.824837676028699 0.204731876778819 no 1008 0.251315896562145 885 NA FF|FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A chromatin remodeling|histone exchange nucleosome binding Swr1 complex|cytoplasm
YER059W YER059W PCL6 hom Verified 0.824745325065168 0.204758096637722 no 1009 0.188087281352172 645 NA FT CELL CYCLE|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Pho85p cyclin of the Pho80p subfamily; forms the major Glc8p kinase together with Pcl7p and Pho85p; involved in the control of glycogen storage by Pho85p; stabilized by Elongin C binding regulation of glycogen catabolic process|regulation of glycogen biosynthetic process cyclin-dependent protein kinase regulator activity cyclin-dependent protein kinase holoenzyme complex
YGL184C YGL184C STR3 hom Verified 0.824633734004317 0.204789781720757 no 1010 0.217949845594099 753 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Peroxisomal cystathionine beta-lyase, converts cystathionine into homocysteine; may be redox regulated by Gto1p methionine biosynthetic process|transsulfuration cystathionine beta-lyase activity peroxisome
YKL188C YKL188C PXA2 hom Verified 0.824540948652721 0.204816129344835 no 1011 0.191340860623781 641 NA FT NUCLEOTIDE METABOLISM Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter ABCD1 and ABCD2 and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder fatty acid transport ATPase activity, coupled to transmembrane movement of substances integral to membrane|integral to peroxisomal membrane
YJL164C YJL164C TPK1 hom Verified 0.82290654739597 0.205280569557625 no 1012 0.201443509329109 673 NA FT CELL CYCLE|SIGNALING|CELL DIVISION|PROTEIN PHOSPHORYLATION NUCLEUS cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; regulates Whi3p; partially redundant with Tpk2p and Tpk3p; TPK1 has a paralog, TPK3, that arose from the whole genome duplication protein phosphorylation|Ras protein signal transduction cAMP-dependent protein kinase activity|protein kinase activity cAMP-dependent protein kinase complex|nucleus|cytoplasm
YLR322W_d YLR322W VPS65 hom Dubious 0.821467918760053 0.205689895235817 no 1013 0.220057012346792 766 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 75% of ORF overlaps the verified gene SFH1; deletion causes a vacuolar protein sorting defect and blocks anaerobic growth Unknown Unknown Unknown
YDR246W-A_p YDR246W-A YDR246W-A hom Uncharacterized 0.820835155590702 0.205870085398026 no 1014 0.19163049296615 654 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YER170W YER170W ADK2 hom Verified 0.819502919434595 0.206249768494182 no 1015 0.207873157806586 760 NA FT NUCLEOTIDE METABOLISM MITOCHONDRION Mitochondrial adenylate kinase, catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background nucleotide metabolic process nucleoside triphosphate adenylate kinase activity|adenylate kinase activity mitochondrion|mitochondrial inner membrane
YPR194C YPR194C OPT2 hom Verified 0.818768621195137 0.206459218488691 no 1016 0.203912385493868 722 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION PLASMA MEMBRANE Oligopeptide transporter; member of the OPT family, with potential orthologs in S. pombe and C. albicans; also plays a role in formation of mature vacuoles oligopeptide transport|vacuole fusion, non-autophagic oligopeptide transporter activity integral to membrane|integral to plasma membrane
YPL056C_p YPL056C LCL1 hom Uncharacterized 0.818126946240156 0.20664235190693 no 1017 0.210080426750159 740 NA FT PLASMA MEMBRANE Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan biological_process molecular_function cellular_component
YOR107W YOR107W RGS2 hom Verified 0.817998447987458 0.206679036743049 no 1018 0.221368445838916 793 NA FT SIGNALING NUCLEUS|PLASMA MEMBRANE Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p adenylate cyclase-modulating G-protein coupled receptor signaling pathway GTPase activator activity nucleus|cytoplasm
YPL090C YPL090C RPS6A hom Verified 0.81777003170593 0.206744256595731 no 1019 0.210667540593108 728 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; RPS6A has a paralog, RPS6B, that arose from the whole genome duplication cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome small-subunit processome|cytosolic small ribosomal subunit|90S preribosome
YDR315C YDR315C IPK1 hom Verified 0.817740653095655 0.206752645974174 no 1020 0.259029205397987 866 NA FT NUCLEUS Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable nuclear-transcribed mRNA catabolic process, non-stop decay|inositol phosphate biosynthetic process inositol pentakisphosphate 2-kinase activity nucleus
YBR129C YBR129C OPY1 hom Verified 0.816888685450742 0.206996022169005 no 1021 0.169658011055298 559 NA FT MITOCHONDRION Protein of unknown function, overproduction blocks cell cycle arrest in the presence of mating pheromone; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion|cytoplasm
YCR079W YCR079W PTC6 hom Verified 0.815797552797045 0.20730796657116 no 1022 0.22321872524192 799 NA FT RESPONSE TO NUTRIENT LEVELS MITOCHONDRION Mitochondrial type 2C protein phosphatase (PP2C) with similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase mitochondrion degradation|positive regulation of catalytic activity|macroautophagy|protein dephosphorylation protein serine/threonine phosphatase activity mitochondrion|mitochondrial matrix|mitochondrial intermembrane space
YGR076C YGR076C MRPL25 hom Verified 0.815749086433098 0.207321829086271 no 1023 0.224385316089862 778 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit; mutation confers increased replicative lifespan mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YOL119C YOL119C MCH4 hom Verified 0.81517468308821 0.207486163631576 no 1024 0.184305521640796 630 NA Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport transport monocarboxylic acid transmembrane transporter activity|transporter activity fungal-type vacuole membrane|integral to membrane
YMR292W YMR292W GOT1 hom Verified 0.813903492781999 0.207850119809745 no 1025 0.187524812710636 656 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Homodimeric protein that is packaged into COPII vesicles and cycles between the ER and Golgi; involved in secretory transport but not directly required for aspects of transport assayed in vitro; may influence membrane composition ER to Golgi vesicle-mediated transport|Golgi to endosome transport molecular_function integral to membrane|endoplasmic reticulum|Golgi apparatus|ER to Golgi transport vesicle|Golgi membrane
YER056C-A YER056C-A RPL34A hom Verified 0.812965030320868 0.208119053988732 no 1026 0.177323593497307 639 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L34A; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34A has a paralog, RPL34B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YMR221C_p YMR221C YMR221C hom Uncharacterized 0.812173670694522 0.208345992588526 no 1027 0.199990375653077 691 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; physical interaction with Atg27p suggests a possible role in autophagy biological_process molecular_function mitochondrion|integral to membrane|fungal-type vacuole
YOR357C YOR357C SNX3 hom Verified 0.81143797218894 0.208557100094117 no 1028 0.210299960988734 722 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p protein localization|late endosome to Golgi transport phosphatidylinositol-3-phosphate binding cytosol|endosome
YNL090W YNL090W RHO2 hom Verified 0.810252840615789 0.208897436783259 no 1029 0.214097274524521 739 NA FT SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION PLASMA MEMBRANE Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, involved in the establishment of cell polarity and in microtubule assembly microtubule-based process|fungal-type cell wall organization|actin filament organization|establishment of cell polarity|small GTPase mediated signal transduction GTPase activity membrane
YLR260W YLR260W LCB5 hom Verified 0.809111991179496 0.209225365751369 no 1030 0.243368915578029 808 NA FT LIPID METABOLISM|SIGNALING|PROTEIN PHOSPHORYLATION ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules response to heat|calcium-mediated signaling|sphingolipid metabolic process D-erythro-sphingosine kinase activity Golgi apparatus|membrane
YLR263W YLR263W RED1 hom Verified 0.808945544444335 0.209273234987308 no 1031 0.181017567460497 617 NA FT CELL CYCLE|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Protein component of the synaptonemal complex axial elements, involved in chromosome segregation during the first meiotic division; critical for coupling checkpoint signaling to SC formation; interacts with Hop1p, Mec3p and Ddc1p synaptonemal complex assembly|meiotic recombination checkpoint|positive regulation of catalytic activity chromatin DNA binding|structural molecule activity lateral element
YNL083W YNL083W SAL1 hom Verified 0.808868523080173 0.209295388122101 no 1032 0.198641742988799 673 NA FT MITOCHONDRION ADP/ATP transporter; member of the Ca2+-binding subfamily of mitochondrial carriers, with two EF-hand motifs; transport activity of either Sal1p or Pet9p is critical for viability; polymorphic in different S. cerevisiae strains ATP transport|ADP transport|mitochondrial transport ATP:ADP antiporter activity|calcium ion binding mitochondrion|integral to membrane|mitochondrial inner membrane
YNR049C YNR049C MSO1 hom Verified 0.808768690694244 0.209324104290879 no 1033 0.207438180827956 712 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Probable component of the secretory vesicle docking complex; acts at a late step in secretion; shows genetic and physical interactions with Sec1p; required for prospore membrane formation during sporulation; relocalizes from bud neck to nucleus upon DNA replication stress cellular membrane fusion|ascospore-type prospore membrane assembly|vesicle docking involved in exocytosis molecular_function SNARE complex|cellular bud membrane|plasma membrane|prospore membrane|cellular bud neck|cellular bud tip
YML011C YML011C RAD33 hom Verified 0.8077031591871 0.209630742265691 no 1034 0.192741089704154 651 NA FT RESPONSE TO DNA DAMAGE NUCLEUS Protein involved in nucleotide excision repair; green fluorescent protein (GFP)-fusion protein localizes to the nucleus nucleotide-excision repair molecular_function nucleus
YNL242W YNL242W ATG2 hom Verified 0.807653626037096 0.209645003306728 no 1035 0.200177353448696 669 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION Peripheral membrane protein required for autophagic vesicle formation; also required for vesicle formation during pexophagy and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria; forms cytoplasmic foci upon DNA replication stress mitochondrion degradation|piecemeal microautophagy of nucleus|peroxisome degradation|CVT pathway|autophagic vacuole assembly molecular_function pre-autophagosomal structure|cytoplasm|extrinsic to membrane
YIL127C_p YIL127C RRT14 hom Uncharacterized 0.806775412931681 0.209897943506543 no 1036 0.198191077137887 695 NA FT NUCLEUS Putative protein of unknown function; identified in a screen for mutants with decreased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis biological_process molecular_function nucleolus
YJR111C_p YJR111C YJR111C hom Uncharacterized 0.806363031407418 0.210016778207498 no 1037 0.2035074865245 730 NA FT OXIDATION-REDUCTION PROCESS MITOCHONDRION Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria biological_process molecular_function mitochondrion
YGL164C YGL164C YRB30 hom Verified 0.805361612000776 0.210305518629461 no 1038 0.207328633317104 711 NA FT PROTEIN LOCALIZATION NUCLEUS RanGTP-binding protein, inhibits RanGAP1 (Rna1p)-mediated GTP hydrolysis of RanGTP (Gsp1p); shares similarity to proteins in other fungi but not in higher eukaryotes biological_process GTPase regulator activity nucleus|cytoplasm
YOR328W YOR328W PDR10 hom Verified 0.805106758736073 0.21037903795956 no 1039 0.199427737118383 654 NA FT NUCLEOTIDE METABOLISM PLASMA MEMBRANE ATP-binding cassette (ABC) transporter, multidrug transporter involved in the pleiotropic drug resistance network; regulated by Pdr1p and Pdr3p drug transmembrane transport ATPase activity, coupled to transmembrane movement of substances integral to membrane|plasma membrane
YNR004W_p YNR004W SWM2 hom Uncharacterized 0.805075069784722 0.210388180550876 no 1040 0.201205922364005 699 NA FT NUCLEUS Putative protein of unknown function; haploid disruptant exhibits cold-sensitive growth and elongated buds biological_process molecular_function nucleolus
YPR150W_d YPR150W YPR150W hom Dubious 0.803968110778994 0.210707696072727 no 1041 0.182792214187624 632 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SUE1/YPR151C Unknown Unknown Unknown
YDR372C YDR372C VPS74 hom Verified 0.803769669612186 0.210765004720723 no 1042 0.248950739659659 841 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33 retrograde vesicle-mediated transport, Golgi to ER|endoplasmic reticulum unfolded protein response|protein localization to Golgi apparatus enzyme binding|phosphatidylinositol-4-phosphate binding cytosol|Golgi apparatus|nucleus|extrinsic to membrane|cytoplasm
YDL191W YDL191W RPL35A hom Verified 0.803706039118209 0.210783382770727 no 1043 0.212565103131815 763 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal 60S subunit protein L35A; homologous to mammalian ribosomal protein L35 and bacterial L29; RPL35A has a paralog, RPL35B, that arose from the whole genome duplication cytoplasmic translation|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic large ribosomal subunit|preribosome, large subunit precursor
YLR429W YLR429W CRN1 hom Verified 0.803649176341601 0.210799806932929 no 1044 0.192592106026507 664 NA FT CYTOSKELETON ORGANIZATION CYTOSKELETON Coronin, cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity; plays a role in regulation of actin patch assembly microtubule-based process|actin filament organization|actin cortical patch localization|Unknown|negative regulation of Arp2/3 complex-mediated actin nucleation microtubule binding|actin filament binding|protein binding, bridging Arp2/3 protein complex|actin cortical patch
YOL112W YOL112W MSB4 hom Verified 0.801665917790128 0.211373117942498 no 1045 0.21391336727785 741 NA FT SIGNALING|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH GTPase-activating protein of the Ras superfamily that acts primarily on Sec4p, localizes to the bud site and bud tip, has similarity to Msb3p; msb3 msb4 double mutation causes defects in secretion and actin organization actin filament organization Rab GTPase activator activity incipient cellular bud site|polarisome|cellular bud tip
YOR171C YOR171C LCB4 hom Verified 0.801653846689422 0.211376610193128 no 1046 0.187271296383159 636 NA FT LIPID METABOLISM|SIGNALING|PROTEIN PHOSPHORYLATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS|PLASMA MEMBRANE Sphingoid long-chain base kinase, responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomes calcium-mediated signaling|sphingolipid metabolic process D-erythro-sphingosine kinase activity Golgi apparatus|endoplasmic reticulum|plasma membrane|cortical endoplasmic reticulum
YBR131W YBR131W CCZ1 hom Verified 0.80082792238258 0.211615635900938 no 1047 0.209643056940626 723 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Protein involved in vacuolar assembly, essential for autophagy and the cytoplasm-to-vacuole pathway autophagy|autophagic vacuole fusion|vacuolar transport|vesicle docking|protein targeting to vacuole guanyl-nucleotide exchange factor activity Mon1-Ccz1 complex|membrane
YHL005C_d YHL005C YHL005C hom Dubious 0.799935648853945 0.211874041046668 no 1048 0.192339644932798 693 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YHL004W Unknown Unknown Unknown
YKR033C_d YKR033C YKR033C hom Dubious 0.799571596947296 0.211979524594316 no 1049 0.21198428916717 679 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene DAL80 Unknown Unknown Unknown
YBL075C YBL075C SSA3 hom Verified 0.798924170027375 0.212167191533775 no 1050 0.222515407778886 780 NA FT PROTEIN LOCALIZATION ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm; SSA3 has a paralog, SSA4, that arose from the whole genome duplication protein folding|SRP-dependent cotranslational protein targeting to membrane, translocation|response to stress unfolded protein binding|ATPase activity cytosol
YKL096W YKL096W CWP1 hom Verified 0.798798577047059 0.212203607892266 no 1051 0.192492761516428 651 NA FT MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS Cell wall mannoprotein that localizes specifically to birth scars of daughter cells, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; required for propionic acid resistance fungal-type cell wall organization|ascospore-type prospore membrane assembly structural constituent of cell wall fungal-type cell wall|cellular birth scar|prospore membrane
YOR277C_d YOR277C YOR277C hom Dubious 0.79808127439367 0.212411663661231 no 1052 0.233283580023771 796 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene CAF20 Unknown Unknown Unknown
YNL123W YNL123W NMA111 hom Verified 0.797177163863566 0.212674073326248 no 1053 0.252025402951375 877 NA FT LIPID METABOLISM|PROTEOLYSIS NUCLEUS Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases apoptotic process|cellular lipid metabolic process|protein catabolic process|cellular response to heat serine-type peptidase activity nucleus
YKR046C YKR046C PET10 hom Verified 0.797017308742743 0.212720489472326 no 1054 0.204906927583585 681 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY Protein of unknown function that co-purifies with lipid particles; expression pattern suggests a role in respiratory growth; computational analysis of large-scale protein-protein interaction data suggests a role in ATP/ADP exchange aerobic respiration molecular_function lipid particle
YKL097C_d YKL097C YKL097C hom Dubious 0.795703192155277 0.213102285512006 no 1055 0.195316170945583 647 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species Unknown Unknown Unknown
YOL079W_d YOL079W YOL079W hom Dubious 0.795557304047294 0.21314469565965 no 1056 0.234133818440168 774 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR134W YLR134W PDC5 hom Verified 0.795119553247115 0.213271980785432 no 1057 0.207145338159853 693 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Minor isoform of pyruvate decarboxylase, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde, regulation is glucose- and ethanol-dependent, repressed by thiamine, involved in amino acid catabolism L-phenylalanine catabolic process|glucose catabolic process to ethanol|pyruvate metabolic process|tryptophan catabolic process|aromatic amino acid family catabolic process to alcohol via Ehrlich pathway pyruvate decarboxylase activity nucleus|cytoplasm
YNR030W YNR030W ALG12 hom Verified 0.794314084294804 0.213506303363096 no 1058 0.244462802770254 812 NA FT LIPID METABOLISM|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Alpha-1,6-mannosyltransferase localized to the ER; responsible for the addition of the alpha-1,6 mannose to dolichol-linked Man7GlcNAc2, acts in the dolichol pathway for N-glycosylation dolichol-linked oligosaccharide biosynthetic process|protein glycosylation alpha-1,6-mannosyltransferase activity integral to membrane|endoplasmic reticulum
YIL133C YIL133C RPL16A hom Verified 0.793801149757416 0.213655601607073 no 1059 0.214244741021394 750 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L16A; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16A has a paralog, RPL16B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress cytoplasmic translation structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YGR101W YGR101W PCP1 hom Verified 0.791686406728907 0.214271775140003 no 1060 0.228727023343813 761 NA FT PROTEOLYSIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial serine protease required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases signal peptide processing|regulation of mitochondrion organization serine-type endopeptidase activity integral to membrane|mitochondrial inner membrane
YIR018W YIR018W YAP5 hom Verified 0.791648542804764 0.214282816978535 no 1061 0.201028887870917 711 NA FT TRANSCRIPTION FROM RNA POL II|GENE SILENCING NUCLEUS|CHROMOSOME Basic leucine zipper (bZIP) iron-sensing transcription factor; YAP5 has a paralog, YAP7, that arose from the whole genome duplication negative regulation of chromatin silencing at telomere|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter in response to iron|positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding RNA polymerase II transcription factor activity nuclear chromatin|nucleus
YBL059W_p YBL059W YBL059W hom Uncharacterized 0.790838185785696 0.214519211790818 no 1062 0.23219126428755 780 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YBL059W has a paralog, YER093C-A, that arose from the whole genome duplication biological_process molecular_function mitochondrion
YKL081W YKL081W TEF4 hom Verified 0.790664526487305 0.21456989085739 no 1063 0.225130863250825 747 NA FT TRANSLATION MITOCHONDRION RIBOSOME Gamma subunit of translational elongation factor eEF1B, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex translational elongation translation elongation factor activity mitochondrion|ribosome|eukaryotic translation elongation factor 1 complex
YDL210W YDL210W UGA4 hom Verified 0.790058997275066 0.214746657137806 no 1064 0.183786455102909 616 NA Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane gamma-aminobutyric acid transport|putrescine transport|transmembrane transport putrescine transmembrane transporter activity|gamma-aminobutyric acid:hydrogen symporter activity fungal-type vacuole membrane|integral to membrane
YKL030W_d YKL030W YKL030W hom Dubious 0.789804681175424 0.214820922398704 no 1065 0.200303910852127 623 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene MAE1 Unknown Unknown Unknown
YCR048W YCR048W ARE1 hom Verified 0.789635255174348 0.214870406375295 no 1066 0.18186324902021 626 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the absence of oxygen; ARE1 has a paralog, ARE2, that arose from the whole genome duplication sterol metabolic process ergosterol O-acyltransferase activity|lanosterol O-acyltransferase activity integral to membrane|endoplasmic reticulum
YLR312W-A YLR312W-A MRPL15 hom Verified 0.789128365997245 0.215018492204899 no 1067 0.222919203306627 765 NA FT RNA PROCESSING|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YPL061W YPL061W ALD6 hom Verified 0.786994458156561 0.215642555155115 no 1068 0.223729645062651 769 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM MITOCHONDRION Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress response to salt stress|NADPH regeneration|acetate biosynthetic process aldehyde dehydrogenase [NAD(P)+] activity cytosol|mitochondrion
YLR133W YLR133W CKI1 hom Verified 0.786970347996106 0.215649612184265 no 1069 0.260923548301883 896 NA FT LIPID METABOLISM Choline kinase; catalyzes the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; CKI1 has a paralog, EKI1, that arose from the whole genome duplication phosphatidylethanolamine biosynthetic process|phosphatidylcholine biosynthetic process ethanolamine kinase activity|choline kinase activity cytoplasm
YDL009C_p YDL009C YDL009C hom Uncharacterized 0.786898578541284 0.215670619852124 no 1070 0.212583110869989 731 NA Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the verified ORF YDL010W; YDL009C is not an essential gene biological_process molecular_function cellular_component
YLR182W YLR182W SWI6 hom Verified 0.786042710724129 0.215921232713311 no 1071 0.253490926788276 881 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE NUCLEUS Transcription cofactor; forms complexes with Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; also binds Stb1p to regulate transcription at START; cell wall stress induces phosphorylation by Mpk1p, which regulates Swi6p localization; required for the unfolded protein response, independently of its known transcriptional coactivators positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription involved in G1/S phase of mitotic cell cycle|positive regulation of reciprocal meiotic recombination|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription coactivator activity SBF transcription complex|MBF transcription complex|nucleus|cytoplasm
YPR030W YPR030W CSR2 hom Verified 0.785299253904765 0.21613906658122 no 1072 0.228779694629678 788 NA FT VESICLE-MEDIATED TRANSPORT|TRANSCRIPTION FROM RNA POL II|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS NUCLEUS Nuclear ubiquitin protein ligase binding protein; may regulate utilization of nonfermentable carbon sources and endocytosis of plasma membrane proteins; overproduction suppresses chs5 spa2 lethality at high temp; ubiquitinated by Rsp5p, deubiquitinated by Ubp2p; CSR2 has a paralog, ECM21, that arose from the whole genome duplication fungal-type cell wall organization|regulation of transcription from RNA polymerase II promoter|ubiquitin-dependent endocytosis ubiquitin protein ligase binding nucleus
YAL056W YAL056W GPB2 hom Verified 0.785279106947854 0.216144971437871 no 1073 0.210249518515522 697 NA FT TRANSCRIPTION FROM RNA POL II|SIGNALING MITOCHONDRION|PLASMA MEMBRANE Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; GPB2 has a paralog, GPB1, that arose from the whole genome duplication signal transduction|glucose mediated signaling pathway|pseudohyphal growth|ascospore formation|negative regulation of Ras protein signal transduction|invasive growth in response to glucose limitation|positive regulation of transcription from RNA polymerase II promoter cAMP-dependent protein kinase inhibitor activity|signal transducer activity|GTPase activating protein binding mitochondrion|plasma membrane|cytoplasm
YGR079W_p YGR079W YGR079W hom Uncharacterized 0.785261661242013 0.216150084662324 no 1074 0.214366903705683 736 NA Putative protein of unknown function; YGR079W is not an essential gene biological_process molecular_function cellular_component
YLR368W YLR368W MDM30 hom Verified 0.784734682491338 0.216304571766365 no 1075 0.207377154726476 718 NA FT MEMBRANE ORGANIZATION|PROTEOLYSIS|MITOCHONDRION ORGANIZATION|RNA LOCALIZATION MITOCHONDRION UBIQUITIN LIGASE COMPLEX F-box component of an SCF ubiquitin protein ligase complex; associates with and is required for Fzo1p ubiquitination and for mitochondria fusion; stimulates nuclear export of specific mRNAs; promotes ubiquitin-mediated degradation of Gal4p in some strains SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|chronological cell aging|proteolysis involved in cellular protein catabolic process|mitochondrion organization|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of mRNA export from nucleus|mitochondrial fusion ubiquitin-protein ligase activity mitochondrion|SCF ubiquitin ligase complex
YBL063W YBL063W KIP1 hom Verified 0.784468029249283 0.216382767173793 no 1076 0.191689626542789 619 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION CYTOSKELETON Kinesin-related motor protein required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; functionally redundant with Cin8p for chromosomal but not plasmid functions mitotic anaphase B|microtubule depolymerization|spindle pole body separation|plasmid partitioning|mitotic sister chromatid segregation microtubule motor activity|structural constituent of cytoskeleton spindle microtubule|kinesin complex|spindle pole body
YBR189W YBR189W RPS9B hom Verified 0.782306453860878 0.217017247441553 no 1077 0.212878838942618 704 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION NUCLEUS RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog, RPS9A, that arose from the whole genome duplication positive regulation of translational fidelity|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome small-subunit processome|cytosolic small ribosomal subunit|90S preribosome
YGL062W YGL062W PYC1 hom Verified 0.781758575321316 0.217178235091598 no 1078 0.208888443671982 704 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc2p; mutations in the human homolog are associated with lactic acidosis; PYC1 has a paralog, PYC2, that arose from the whole genome duplication NADPH regeneration|gluconeogenesis pyruvate carboxylase activity cytosol
YDL074C YDL074C BRE1 hom Verified 0.781113502906978 0.21736787041915 no 1079 0.283370698943562 966 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING NUCLEUS|CHROMOSOME E3 ubiquitin ligase, forms heterodimer with Rad6p to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR, transcription, silencing, and checkpoint control mitotic cell cycle G1/S transition DNA damage checkpoint|intra-S DNA damage checkpoint|meiotic DNA double-strand break formation|histone monoubiquitination|double-strand break repair via homologous recombination|transcription from RNA polymerase II promoter|chromatin silencing at telomere ubiquitin-protein ligase activity nuclear chromatin
YMR138W YMR138W CIN4 hom Verified 0.77961985665658 0.217807332269275 no 1080 0.2284939323281 784 NA FT SIGNALING GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; regulated by the GTPase-activating protein, Cin2p, the human retinitis pigmentosa 2 (RP2) homolog protein folding|tubulin complex assembly|tubulin complex biogenesis GTP binding cytoplasm
YNL322C YNL322C KRE1 hom Verified 0.776297580716821 0.2187866506035 no 1081 0.234890172627873 849 NA FT CELL WALL ORG/BIOGENESIS PLASMA MEMBRANE Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor fungal-type cell wall organization structural constituent of cell wall fungal-type cell wall|integral to membrane
YCR086W YCR086W CSM1 hom Verified 0.776289814908836 0.218788942720902 no 1082 0.212319951902453 730 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CHROMOSOME SEGREGATION ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME KINETOCHORE Nucleolar protein that forms a complex with Lrs4p and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation meiotic chromosome segregation|rDNA condensation|protein localization to nucleolar rDNA repeats|homologous chromosome segregation molecular_function nuclear envelope|nucleolus|monopolin complex
YHR034C YHR034C PIH1 hom Verified 0.774776844463179 0.219235767102931 no 1083 0.239055482131529 798 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II protein folding|rRNA processing|regulation of cell size|box C/D snoRNP assembly molecular_function R2TP complex|nucleus|small nucleolar ribonucleoprotein complex|cytoplasm
YGL125W YGL125W MET13 hom Verified 0.774397498565798 0.219347881221475 no 1084 0.230611976943783 743 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION Major isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway methionine biosynthetic process methylenetetrahydrofolate reductase (NADPH) activity mitochondrion
YKR040C_d YKR040C YKR040C hom Dubious 0.774114465064439 0.219431552065078 no 1085 0.210970630944994 717 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YKR041W Unknown Unknown Unknown
YOR132W YOR132W VPS17 hom Verified 0.773361457318488 0.219654246760715 no 1086 0.218117878428451 753 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM Subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde protein transport; peripheral membrane protein that assembles onto the membrane with Vps5p to promote vesicle formation; required for recruiting the retromer complex to the endosome membranes retrograde transport, endosome to Golgi protein transporter activity|phosphatidylinositol-3-phosphate binding endosome|retromer complex, outer shell|retromer complex
YPL199C_p YPL199C YPL199C hom Uncharacterized 0.772923399316663 0.219783857828807 no 1087 0.220834815482369 778 NA Putative protein of unknown function, predicted to be palmitoylated biological_process molecular_function cytoplasm
YFR039C_p YFR039C YFR039C hom Uncharacterized 0.772799337390007 0.219820572813304 no 1088 0.194233713423068 634 NA Putative protein of unknown function; may be involved in response to high salt and changes in carbon source; deletion mutant has decreased spore survival in Drosophila feces biological_process molecular_function cellular_component
YNL034W_p YNL034W YNL034W hom Uncharacterized 0.771388921745964 0.22023821977391 no 1089 0.213024303425973 708 NA Putative protein of unknown function; YNL034W is not an essential gene biological_process molecular_function cellular_component
YHR127W YHR127W YHR127W hom Verified 0.771304605258239 0.220263201659397 no 1090 0.210513277107447 698 NA FT CELL CYCLE|CYTOSKELETON ORGANIZATION NUCLEUS Protein of unknown function; localizes to the nucleus; required for asymmetric localization of Kar9p during mitosis mitotic spindle elongation molecular_function nucleus
YKL132C YKL132C RMA1 hom Verified 0.770601939653862 0.220471455577125 no 1091 0.199015629754528 647 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM MITOCHONDRION Putative dihydrofolate synthetase; has similarity to Fol3p and to E. coli folylpolyglutamate synthetase/dihydrofolate synthetase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process tetrahydrofolylpolyglutamate synthase activity mitochondrion
YER163C YER163C GCG1 hom Verified 0.769600668363786 0.220768404219404 no 1092 0.218611816709202 743 NA FT NUCLEUS Gamma-glutamyl cyclotransferase; cleaves the gamma-glutamyl bond of glutathione to yield 5-oxoproline and a Cys-Gly dipeptide; similar to mammalian pro-apoptotic protein ChaC1; expression of mouse ChaC1 in yeast increases apoptosis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; periodically expressed during the metabolic cycle biological_process molecular_function nucleus|cytoplasm
YNL248C YNL248C RPA49 hom Verified 0.769586069703401 0.220772735461071 no 1093 0.207403121630592 705 NA FT NUCLEUS RNA polymerase I subunit A49 transcription elongation from RNA polymerase I promoter|transcription of nuclear large rRNA transcript from RNA polymerase I promoter|regulation of cell size molecular_function DNA-directed RNA polymerase I complex
YMR135W-A_d YMR135W-A YMR135W-A hom Dubious 0.768731752130207 0.221026285635321 no 1094 0.185022023753332 570 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOR140W YOR140W SFL1 hom Verified 0.765613369902495 0.221953193398683 no 1095 0.216255077996865 740 NA FT TRANSCRIPTION FROM RNA POL II|GENE SILENCING NUCLEUS Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p gene silencing|Unknown|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II repressing transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity nucleus
YOR300W_d YOR300W YOR300W hom Dubious 0.765136952400864 0.222094998908314 no 1096 0.20153910981664 686 NA Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7 Unknown Unknown Unknown
YPR126C_d YPR126C YPR126C hom Dubious 0.764635312086787 0.222244367858625 no 1097 0.224007283821256 726 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YKL149C YKL149C DBR1 hom Verified 0.76452795067706 0.222276343350646 no 1098 0.209763923235125 722 NA FT RNA PROCESSING NUCLEUS RNA lariat debranching enzyme, involved in intron turnover; required for efficient Ty1 transposition snoRNA metabolic process|pseudohyphal growth|RNA catabolic process|transposition, RNA-mediated RNA lariat debranching enzyme activity nucleus
YLR406C YLR406C RPL31B hom Verified 0.76386994202766 0.222472375666161 no 1099 0.256644774541182 886 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L31B; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31B has a paralog, RPL31A, that arose from the whole genome duplication cytoplasmic translation|regulation of translational fidelity structural constituent of ribosome cytosolic large ribosomal subunit
YOL013W-A_p YOL013W-A YOL013W-A hom Uncharacterized 0.763799117283974 0.222493481474917 no 1100 0.221122648172129 747 NA Putative protein of unknown function; identified by SAGE biological_process molecular_function integral to membrane
YKR034W YKR034W DAL80 hom Verified 0.763244424458112 0.22265881969718 no 1101 0.219870307283005 752 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS NUCLEUS Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Gzf3p; DAL80 has a paralog, GZF3, that arose from the whole genome duplication nitrogen catabolite repression of transcription|negative regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity nucleus
YKL207W YKL207W EMC3 hom Verified 0.763015958164195 0.222726939387568 no 1102 0.205875666133365 753 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; required for respiratory growth; null mutant displays induction of the unfolded protein response; homologous to worm Y62E10A.10/EMC-3, fly CG6750, human TMEM111 protein folding in endoplasmic reticulum molecular_function ER membrane protein complex|integral to membrane
YOR349W YOR349W CIN1 hom Verified 0.762742119166313 0.22280860308689 no 1103 0.224703714070546 834 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl protein folding|tubulin complex assembly|tubulin complex biogenesis beta-tubulin binding cellular_component
YLR126C YLR126C YLR126C hom Verified 0.762418619976541 0.222905098325309 no 1104 0.211380790723361 740 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS Putative glutamine amidotransferase; has Aft1p-binding motif in the promoter; may be involved in copper and iron homeostasis; YLR126C is not an essential protein; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress cellular copper ion homeostasis|cellular iron ion homeostasis molecular_function cytoplasm
YER119C-A_d YER119C-A YER119C-A hom Dubious 0.761792983969641 0.223091784234858 no 1105 0.259920021920998 919 NA FF Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene SCS2 Unknown Unknown Unknown
YPL219W YPL219W PCL8 hom Verified 0.761267264101474 0.223248724600717 no 1106 0.240847020787119 806 NA FT CELL CYCLE|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylation negative regulation of glycogen biosynthetic process cyclin-dependent protein kinase regulator activity cyclin-dependent protein kinase holoenzyme complex
YPR173C YPR173C VPS4 hom Verified 0.760912682688251 0.223354611386733 no 1107 0.256969426662823 883 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|LIPID METABOLISM|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT ENDOPLASMIC RETICULUM AAA-ATPase involved in multivesicular body (MVB) protein sorting, ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism late endosome to vacuole transport via multivesicular body sorting pathway|protein retention in Golgi apparatus|intralumenal vesicle formation|protein homooligomerization|sterol metabolic process|late endosome to vacuole transport ATPase activity|protein homodimerization activity|ATP binding endosome|endoplasmic reticulum|membrane|cytoplasm
YCL051W YCL051W LRE1 hom Verified 0.76028463056086 0.223542233418549 no 1108 0.238616617948553 820 NA FT CELL WALL ORG/BIOGENESIS Protein involved in control of cell wall structure and stress response; overproduction confers resistance to cell-wall degrading enzymes; exhibits genetic interactions with genes involved in the cell wall integrity pathway;
LRE1 has a paralog, HLR1, that arose from the whole genome duplication fungal-type cell wall organization molecular_function cellular_component
YGL038C YGL038C OCH1 hom Verified 0.759996255085849 0.223628411690694 no 1109 0.283074782912078 986 NA FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Mannosyltransferase of the cis-Golgi apparatus, initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins protein N-linked glycosylation alpha-1,6-mannosyltransferase activity|transferase activity, transferring glycosyl groups Golgi cis cisterna
YPL177C YPL177C CUP9 hom Verified 0.759544268224385 0.223763521675606 no 1110 0.229097873320387 823 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Homeodomain-containing transcriptional repressor; regulates expression of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription; CUP9 has a paralog, TOS8, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter|negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter RNA polymerase II repressing transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity nucleus
YLR052W YLR052W IES3 hom Verified 0.757686113133093 0.224319457180995 no 1111 0.224958441929441 749 NA FT CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Subunit of the INO80 chromatin remodeling complex nucleosome mobilization|telomere maintenance|chromatin silencing at telomere molecular_function nucleus|Ino80 complex
YGL015C_p YGL015C YGL015C hom Uncharacterized 0.756443431299736 0.224691688317748 no 1112 0.206547084241108 701 NA Putative protein of unknown function; null mutants accumulate cargo in the Golgi biological_process molecular_function cellular_component
YBL089W YBL089W AVT5 hom Verified 0.755144820568407 0.225081046368832 no 1113 0.254421126064674 847 NA Putative transporter; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; AVT5 has a paralog, AVT6, that arose from the whole genome duplication transport transporter activity integral to membrane
YDR471W YDR471W RPL27B hom Verified 0.754752640162679 0.225198707605972 no 1114 0.220779816568595 737 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L27B; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27B has a paralog, RPL27A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YGL088W_d YGL088W YGL088W hom Dubious 0.754108111824798 0.225392153460823 no 1115 0.225740728667651 743 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps snR10, a snoRNA required for preRNA processing Unknown Unknown Unknown
YKL204W YKL204W EAP1 hom Verified 0.753894128321155 0.225456398309717 no 1116 0.254373684277084 863 NA FT TRANSLATION eIF4E-associated protein, competes with eIF4G for binding to eIF4E; accelerates mRNA degradation by promoting decapping, facilitated by interaction with eIF4E; essential for Puf5p mediated repression; associates with Puf5p and Dhh1p; inhibits cap-dependent translation; functions independently of eIF4E to maintain genetic stability; plays a role in cell growth, implicated in the TOR signaling cascade negative regulation of translation eukaryotic initiation factor 4E binding mRNA cap binding complex|cytoplasmic stress granule
YMR252C_p YMR252C YMR252C hom Uncharacterized 0.752228707958847 0.225956766149458 no 1117 0.209170565908271 737 NA FT MITOCHONDRION Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YMR252C is not an essential gene biological_process molecular_function mitochondrion
YGR173W YGR173W RBG2 hom Verified 0.751400540712347 0.226205818710374 no 1118 0.221859052086169 705 NA FT TRANSLATION Protein with a role in translation; forms a complex with Gir2p; has similarity to mammalian developmentally regulated GTP-binding protein cytoplasmic translation GTP binding cytoplasm
YML053C_p YML053C YML053C hom Uncharacterized 0.748916787130772 0.22695368079321 no 1119 0.223579080202436 730 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene biological_process molecular_function nucleus|cytoplasm
YPR027C_p YPR027C YPR027C hom Uncharacterized 0.746890926212231 0.227564701797925 no 1120 0.245779369395158 888 NA Putative protein of unknown function biological_process molecular_function cellular_component
YKL142W YKL142W MRP8 hom Verified 0.745815057527996 0.227889571356585 no 1121 0.22317958066198 749 NA Protein of unknown function; undergoes sumoylation; transcription induced under cell wall stress; protein levels are reduced under anaerobic conditions; protein abundance increases in response to DNA replication stress; originally thought to be a mitochondrial ribosomal protein based on sequence analysis biological_process molecular_function cytoplasm
YHR157W YHR157W REC104 hom Verified 0.744608290479973 0.228254277310042 no 1122 0.21343341708222 764 NA FT CELL CYCLE NUCLEUS|CHROMOSOME Protein involved in early stages of meiotic recombination; required for meiotic crossing over; forms a complex with Rec102p and Spo11p necessary during the initiation of recombination meiotic DNA double-strand break formation|reciprocal meiotic recombination molecular_function condensed nuclear chromosome
YGL045W YGL045W RIM8 hom Verified 0.744585429461921 0.228261189471681 no 1123 0.263344023513457 891 NA FF|FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family meiosis|protein processing|invasive growth in response to glucose limitation|ubiquitin-dependent endocytosis molecular_function internal side of plasma membrane
YDR260C YDR260C SWM1 hom Verified 0.744353842182735 0.228331217864034 no 1124 0.232804179094597 803 NA FT CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|PROTEOLYSIS NUCLEUS UBIQUITIN LIGASE COMPLEX Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation ascospore wall assembly|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|regulation of mitotic metaphase/anaphase transition|protein ubiquitination molecular_function anaphase-promoting complex|nucleus
YJL022W_d YJL022W YJL022W hom Dubious 0.743411993578308 0.228616142610246 no 1125 0.23769260442339 766 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130 Unknown Unknown Unknown
YLL062C YLL062C MHT1 hom Verified 0.74250023541269 0.228892154610202 no 1126 0.224615045897446 751 NA FT KETONE METABOLISM|AMINO ACID METABOLISM S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio sulfur amino acid metabolic process homocysteine S-methyltransferase activity cytoplasm
YJR115W_p YJR115W YJR115W hom Uncharacterized 0.741902943226791 0.229073071233036 no 1127 0.208386355955128 683 NA Putative protein of unknown function; YJR115W has a paralog, ECM13, that arose from the whole genome duplication biological_process molecular_function cellular_component
YFR040W YFR040W SAP155 hom Verified 0.741258686367098 0.229268303098061 no 1128 0.239408384120956 845 NA FT CELL CYCLE Protein required for function of the Sit4p protein phosphatase; forms a complex with Sit4p; member of a family of similar proteins including Sap4p, Sap185p, and Sap190p; protein abundance increases in response to DNA replication stress G1/S transition of mitotic cell cycle protein serine/threonine phosphatase activity cytoplasm
YLR390W YLR390W ECM19 hom Verified 0.739568001853234 0.229781081720394 no 1129 0.257374595120154 907 NA FT CELL WALL ORG/BIOGENESIS MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies fungal-type cell wall organization molecular_function mitochondrion
YKL093W YKL093W MBR1 hom Verified 0.739492911266136 0.229803871314463 no 1130 0.220192948330298 795 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants aerobic respiration molecular_function cellular_component
YGL019W YGL019W CKB1 hom Verified 0.737839827614883 0.230305893902439 no 1131 0.267185115464229 904 NA FF|FT RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION NUCLEUS Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases regulation of transcription from RNA polymerase I promoter|protein phosphorylation|regulation of transcription from RNA polymerase III promoter|response to DNA damage stimulus protein kinase regulator activity|protein serine/threonine kinase inhibitor activity protein kinase CK2 complex|UTP-C complex
YGL146C_p YGL146C RRT6 hom Uncharacterized 0.737652052915781 0.230362957692449 no 1132 0.204399140326177 679 NA Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins biological_process molecular_function membrane
YBR182C YBR182C SMP1 hom Verified 0.737170046187628 0.23050947330706 no 1133 0.214692563873684 760 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Putative transcription factor of the MADS-box family; involved in regulating the response to osmotic stress; SMP1 has a paralog, RLM1, that arose from the whole genome duplication positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress DNA binding, bending|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nucleus|cytoplasm
YGR124W YGR124W ASN2 hom Verified 0.736153105025396 0.230818763771191 no 1134 0.224516293495383 781 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN2 has a paralog, ASN1, that arose from the whole genome duplication asparagine biosynthetic process asparagine synthase (glutamine-hydrolyzing) activity cytoplasm
YKR028W YKR028W SAP190 hom Verified 0.734954979522183 0.231183456477547 no 1135 0.230714968985222 771 NA FT CELL CYCLE|RNA PROCESSING|SIGNALING Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication TOR signaling cascade|dephosphorylation|G1/S transition of mitotic cell cycle|tRNA wobble uridine modification molecular_function cytoplasm
YPL098C YPL098C MGR2 hom Verified 0.734533942007277 0.231311690730285 no 1136 0.258082132168374 881 NA FT MITOCHONDRION Subunit of the TIM23 translocase complex; acts to couple Tim21p with the core Tim23 translocase; absolutely required for mitochondrial import of presequence-containing proteins at elevated temperature; required for viability of cells lacking the mitochondrial genome (petite-negative phenotype) protein import into mitochondrial matrix molecular_function mitochondrial inner membrane presequence translocase complex
YBR227C YBR227C MCX1 hom Verified 0.734068231760472 0.231453577035911 no 1137 0.240007142644906 835 NA FT MITOCHONDRION Mitochondrial matrix protein; putative ATP-binding chaperone with non-proteolytic function; similar to bacterial ClpX proteins protein refolding molecular_function mitochondrion|mitochondrial matrix
YGL249W YGL249W ZIP2 hom Verified 0.733172989609663 0.231726463572637 no 1138 0.19554437936063 644 NA FT CELL CYCLE|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Meiosis-specific protein; involved in normal synaptonemal complex formation and pairing between homologous chromosomes during meiosis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress synaptonemal complex assembly|synapsis|reciprocal meiotic recombination molecular_function synaptonemal complex
YOR129C YOR129C AFI1 hom Verified 0.733099686840443 0.23174881556384 no 1139 0.217980663026474 747 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION NUCLEUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Arf3p polarization-specific docking factor, required for the polarized distribution of the ADP-ribosylation factor, Arf3p; participates in polarity development and maintenance of a normal haploid budding pattern; interacts with Cnm7p asymmetric protein localization|actin cortical patch localization|cellular bud site selection molecular_function nucleus|plasma membrane|cellular bud neck|cytoplasm
YOR225W_d YOR225W YOR225W hom Dubious 0.732991703624757 0.231781744746503 no 1140 0.23632613984748 827 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YIL125W YIL125W KGD1 hom Verified 0.730131863640008 0.232654793097882 no 1141 0.246669568672078 825 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA tricarboxylic acid cycle|2-oxoglutarate metabolic process oxoglutarate dehydrogenase (succinyl-transferring) activity mitochondrial nucleoid|mitochondrion|mitochondrial matrix|mitochondrial oxoglutarate dehydrogenase complex
YPR003C_p YPR003C YPR003C hom Uncharacterized 0.729330608310096 0.23289972672794 no 1142 0.23598584914529 785 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Putative sulfate permease; physically interacts with Hsp82p; green fluorescent protein (GFP)-fusion protein localizes to the ER; YPR003C is not an essential gene biological_process molecular_function integral to membrane|endoplasmic reticulum
YIL128W YIL128W MET18 hom Verified 0.729223056913781 0.232932614731434 no 1143 0.373512851089358 1233 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|RESPONSE TO DNA DAMAGE NUCLEUS Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Cia2p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human MMS19 methionine metabolic process|nucleotide-excision repair|transcription from RNA polymerase II promoter molecular_function cytoplasm
YKR072C YKR072C SIS2 hom Verified 0.727370752945486 0.233499433001092 no 1144 0.280973830250528 959 NA FF|FT CELL CYCLE|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM NUCLEUS Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis regulation of mitotic cell cycle|response to salt stress|coenzyme A biosynthetic process phosphopantothenoylcysteine decarboxylase activity|protein phosphatase inhibitor activity phosphopantothenoylcysteine decarboxylase complex|nucleus|cytoplasm
YDR249C_p YDR249C YDR249C hom Uncharacterized 0.726200220732215 0.233858018339763 no 1145 0.227394349913662 761 NA Putative protein of unknown function biological_process molecular_function cellular_component
YLR077W YLR077W FMP25 hom Verified 0.723296958860226 0.234748730397913 no 1146 0.241601531756201 836 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial inner membrane protein required for an early step in assembly of respiratory complex III (cytochrome bc1 complex); mRNA is targeted to mitochondria mitochondrial respiratory chain complex III assembly molecular_function mitochondrion|integral to mitochondrial inner membrane
YOR221C YOR221C MCT1 hom Verified 0.722873974220249 0.234878657174346 no 1147 0.274869045275668 953 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Predicted malonyl-CoA:ACP transferase, putative component of a type-II mitochondrial fatty acid synthase that produces intermediates for phospholipid remodeling fatty acid metabolic process|aerobic respiration [acyl-carrier-protein] S-malonyltransferase activity mitochondrion
YCR050C_p YCR050C YCR050C hom Uncharacterized 0.722621963785856 0.234956085265159 no 1148 0.202203839753992 708 NA Non-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein biological_process molecular_function cellular_component
YIL052C YIL052C RPL34B hom Verified 0.720885441084389 0.235490000531085 no 1149 0.269005475589935 957 NA FF|FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YDR511W YDR511W ACN9 hom Verified 0.719907801263578 0.235790882218545 no 1150 0.197430394227567 671 NA FT KETONE METABOLISM|CARBOHYDRATE METABOLISM MITOCHONDRION Protein of the mitochondrial intermembrane space, required for acetate utilization and gluconeogenesis; has orthologs in higher eukaryotes carbon utilization|regulation of gluconeogenesis molecular_function mitochondrion|mitochondrial intermembrane space
YHR066W YHR066W SSF1 hom Verified 0.719644570888698 0.235871931078753 no 1151 0.218278257565131 747 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS NUCLEUS Constituent of 66S pre-ribosomal particles; required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family; SSF1 has a paralog, SSF2, that arose from the whole genome duplication conjugation with cellular fusion|ribosomal large subunit assembly|regulation of cell size rRNA binding nucleolus
YOR076C YOR076C SKI7 hom Verified 0.718652129039219 0.236177642837532 no 1152 0.246109271724714 827 NA FT TRANSLATION|NUCLEOTIDE METABOLISM Coupling protein that mediates interactions between the Ski complex and the cytoplasmic exosome during 3'-5' RNA degradation; eRF3-like domain targets nonstop mRNA for degradation; null mutants have superkiller phenotype nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, non-stop decay|nonfunctional rRNA decay protein binding, bridging Ski complex|cytoplasmic exosome (RNase complex)|cytoplasm
YNR024W YNR024W MPP6 hom Verified 0.7183133266285 0.236282057470442 no 1153 0.234356878119515 775 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Nuclear exosome-associated RNA binding protein; involved in surveillance of pre-rRNAs and pre-mRNAs, and the degradation of cryptic non-coding RNAs (ncRNA); copurifies with ribosomes nuclear mRNA surveillance of spliceosomal pre-mRNA splicing|nuclear mRNA surveillance of mRNA 3'-end processing|nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) poly(U) RNA binding ribosome|nucleus|nuclear exosome (RNase complex)|TRAMP complex
YGR121W-A_p YGR121W-A YGR121W-A hom Uncharacterized 0.717614266716544 0.236497579234937 no 1154 0.230608196780002 786 NA Putative protein of unknown function biological_process molecular_function cellular_component
YBL058W YBL058W SHP1 hom Verified 0.716987585991453 0.236690878261427 no 1155 0.200917059854443 638 NA FT PROTEIN LOCALIZATION|CELL CYCLE|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEOLYSIS|CYTOSKELETON ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY|CHROMOSOME SEGREGATION NUCLEUS UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p; interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate glycogen metabolic process|proteasomal ubiquitin-dependent protein catabolic process|piecemeal microautophagy of nucleus|ER-associated protein catabolic process|ascospore formation|sister chromatid biorientation|autophagic vacuole assembly protein phosphatase type 1 regulator activity nucleus|cytoplasm
YMR313C YMR313C TGL3 hom Verified 0.716726774140378 0.236771351012197 no 1156 0.231216309883366 809 NA FT LIPID METABOLISM|CELL DIVISION Bifunctional enzyme with triacylglycerol lipase and lysophosphatidylethanolamine acyltransferase activity; responsible for all the triacylglycerol lipase activity of the lipid particle; required with Tgl4p for timely bud formation triglyceride catabolic process|cell budding|cellular lipid metabolic process triglyceride lipase activity|lysophosphatidylethanolamine acyltransferase activity lipid particle
YPL173W YPL173W MRPL40 hom Verified 0.716012126449389 0.236991930593598 no 1157 0.254876903730597 874 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YGL007W_d YGL007W BRP1 hom Dubious 0.714999623788172 0.237304637873389 no 1158 0.292130304359864 1017 NA FF Dubious ORF located in the upstream region of PMA1, deletion leads to polyamine resistance due to downregulation of PMA1 Unknown Unknown Unknown
YOR030W YOR030W DFG16 hom Verified 0.713358372710791 0.237812012517177 no 1159 0.27221452303743 975 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS Probable multiple transmembrane protein; involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; is glycosylated and phosphorylated; interacts with Rim21p and Rim9p in the plasma membrane to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; required for accumulation of processed Rim101p pseudohyphal growth|protein processing molecular_function integral to membrane
YDR067C_p YDR067C OCA6 hom Uncharacterized 0.713349982135329 0.237814607898582 no 1160 0.258672560886042 875 NA Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying positive-strand RNA virus replication; null mutation confers sensitivity to tunicamycin and DTT biological_process molecular_function cytoplasm
YNR050C YNR050C LYS9 hom Verified 0.711797919803705 0.238294960519763 no 1161 0.248083080305299 836 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, the seventh step in lysine biosynthesis pathway; exhibits genetic and physical interactions with TRM112 lysine biosynthetic process via aminoadipic acid saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity cytoplasm
YDL025C YDL025C RTK1 hom Verified 0.711455846660405 0.238400901233938 no 1162 0.280652838560828 974 NA FT PROTEIN PHOSPHORYLATION Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance increases in response to DNA replication stress biological_process protein serine/threonine kinase activity|protein kinase activity cellular_component
YMR243C YMR243C ZRC1 hom Verified 0.709565875320552 0.238986693654175 no 1163 0.240033535969046 824 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Vacuolar membrane zinc transporter; transports zinc from cytosol to vacuole for storage; also has role in resistance to zinc shock resulting from sudden influx of zinc into cytoplasm; human ortholog SLC30A10 functions as a Mn transporter and mutations in SLC30A10 cause neurotoxic accumulation of Mn in liver and brain; ZRC1 has a paralog, COT1, that arose from the whole genome duplication cobalt ion transport|cellular zinc ion homeostasis|zinc ion transport|glutathione metabolic process zinc ion transmembrane transporter activity|inorganic cation transmembrane transporter activity integral to membrane|fungal-type vacuole
YMR167W YMR167W MLH1 hom Verified 0.709282071828731 0.239074725826868 no 1164 0.213011207900435 720 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION|CHROMOSOME Protein required for mismatch repair in mitosis and meiosis as well as crossing over during meiosis; forms a complex with Pms1p and Msh2p-Msh3p during mismatch repair; human homolog is associated with hereditary non-polyposis colon cancer mismatch repair|meiotic mismatch repair|reciprocal meiotic recombination|meiotic heteroduplex formation double-stranded DNA binding|DNA insertion or deletion binding|loop DNA binding|single-stranded DNA binding|dinucleotide insertion or deletion binding|ATPase activity|ATP binding mitochondrion|nucleus|MutLalpha complex|MutLbeta complex|cytoplasm
YGL025C YGL025C PGD1 hom Verified 0.709029070002105 0.239153218663078 no 1165 0.304772431990272 1045 NA FF|FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II repressing transcription factor binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription factor recruiting transcription factor activity core mediator complex
YPL208W YPL208W RKM1 hom Verified 0.708264780446263 0.239390422048515 no 1166 0.237572745997025 805 NA FT NUCLEUS SET-domain lysine-N-methyltransferase, catalyzes the formation of dimethyllysine residues on the large ribsomal subunit proteins L23a (Rpl23Ap and Rpl23Bp) and L18 (Rps18Ap and Rps18Bp) peptidyl-lysine dimethylation protein-lysine N-methyltransferase activity nucleus|cytoplasm
YBR039W YBR039W ATP3 hom Verified 0.707708871211676 0.239563033620478 no 1167 0.264135944512044 936 NA FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS MITOCHONDRION Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis ATP synthesis coupled proton transport proton-transporting ATPase activity, rotational mechanism mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase, central stalk
YDL024C YDL024C DIA3 hom Verified 0.707112516796687 0.239748279062748 no 1168 0.266319078139504 927 NA Protein of unknown function, involved in invasive and pseudohyphal growth pseudohyphal growth|invasive growth in response to glucose limitation acid phosphatase activity fungal-type cell wall
YGL229C YGL229C SAP4 hom Verified 0.705380046106429 0.240286879133857 no 1169 0.245214266103723 799 NA FT CELL CYCLE MITOCHONDRION Protein required for function of the Sit4p protein phosphatase, member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p G1/S transition of mitotic cell cycle protein serine/threonine phosphatase activity mitochondrion|cytoplasm
YER075C YER075C PTP3 hom Verified 0.705163249536998 0.240354324431429 no 1170 0.219983672671242 764 NA FT PROTEIN LOCALIZATION|SIGNALING|PROTEIN PHOSPHORYLATION NUCLEUS Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the cytoplasm inactivation of MAPK activity involved in osmosensory signaling pathway|regulation of sporulation|regulation of protein localization|protein dephosphorylation|inactivation of MAPK activity involved in conjugation with cellular fusion protein tyrosine phosphatase activity nucleus|cytoplasm
YJL172W YJL172W CPS1 hom Verified 0.704597513058955 0.240530373308551 no 1171 0.260824771556723 850 NA FT PROTEOLYSIS Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions nitrogen compound metabolic process|proteolysis involved in cellular protein catabolic process carboxypeptidase activity fungal-type vacuole lumen
YJL029C YJL029C VPS53 hom Verified 0.704296283878952 0.240624140040111 no 1172 0.20737180429164 706 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT GOLGI APPARATUS Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; required for vacuolar protein sorting Golgi to vacuole transport|retrograde transport, endosome to Golgi molecular_function Golgi apparatus|GARP complex|cytoplasm
YJL073W YJL073W JEM1 hom Verified 0.703821250367809 0.240772049072621 no 1173 0.247658990063516 877 NA FT PROTEOLYSIS ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM DnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane; exhibits genetic interactions with KAR2 karyogamy involved in conjugation with cellular fusion|ER-associated protein catabolic process|protein folding in endoplasmic reticulum unfolded protein binding|chaperone binding endoplasmic reticulum|nuclear outer membrane-endoplasmic reticulum membrane network
YKL126W YKL126W YPK1 hom Verified 0.70293616748648 0.241047765234637 no 1174 0.388671910115926 1322 NA FF|FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Serine/threonine protein kinase; phosphorylates and downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p (inhibitors of serine:palmitoyl-coenzyme A transferase) by phosphorylation in response to compromised sphingolipid synthesis; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK; YPK1 has a paralog, YPK2, that arose from the whole genome duplication eisosome assembly|protein autophosphorylation|negative regulation of phospholipid translocation|protein phosphorylation protein serine/threonine kinase activity cytosol|plasma membrane|cellular bud neck
YDR075W YDR075W PPH3 hom Verified 0.701862214161251 0.241382547694089 no 1175 0.216344220128751 742 NA FT CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Catalytic subunit of protein phosphatase PP4 complex; active complex is composed of Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; involved in activation of Gln3p to alleviate nitrogen catabolite repression; Pph3p and Psy2p localize to foci on meiotic chromosomes Unknown|signal transduction involved in meiotic recombination checkpoint|double-strand break repair via homologous recombination|protein dephosphorylation|positive regulation of nitrogen compound metabolic process protein serine/threonine phosphatase activity condensed nuclear chromosome|nucleus|cytoplasm
YML055W YML055W SPC2 hom Verified 0.699875811188737 0.242002432353366 no 1176 0.262151141234926 920 NA FT PROTEIN LOCALIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC25 signal peptide processing|protein targeting to ER peptidase activity signal peptidase complex
YNL101W YNL101W AVT4 hom Verified 0.699496346049473 0.242120947869803 no 1177 0.231426217399178 798 NA FT VACUOLAR TRANSPORT Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters amino acid export from vacuole transporter activity|L-glutamine transmembrane transporter activity|L-isoleucine transmembrane transporter activity|L-tyrosine transmembrane transporter activity fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YOL061W YOL061W PRS5 hom Verified 0.697851016134999 0.242635185334188 no 1178 0.247245308602527 843 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; forms cytoplasmic foci upon DNA replication stress fungal-type cell wall organization|5-phosphoribose 1-diphosphate biosynthetic process ribose phosphate diphosphokinase activity cytoplasm
YPL181W YPL181W CTI6 hom Verified 0.697493604936339 0.242746970075962 no 1179 0.253765396085174 885 NA FT CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain negative regulation of chromatin silencing at silent mating-type cassette|positive regulation of transcription, DNA-dependent|regulation of DNA-dependent DNA replication initiation|negative regulation of chromatin silencing at telomere|negative regulation of chromatin silencing at rDNA methylated histone residue binding|transcription factor binding Rpd3L-Expanded complex|nucleus|Rpd3L complex
YIR044C YIR044C YIR044C hom pseudogene 0.695497953235417 0.24337164671563 no 1180 0.246004003257566 826 NA Possible pseudogene in strain S288C; YIR044C and the adjacent ORF, YIR043C, together may encode a non-functional member of the conserved, often subtelomerically-encoded Cos protein family biological_process molecular_function cellular_component
YPR109W_p YPR109W YPR109W hom Uncharacterized 0.694823700987757 0.24358289654633 no 1181 0.26376987867386 881 NA FT CELL CYCLE Predicted membrane protein; dipoid deletion strain has high budding index biological_process molecular_function cellular_component
YDR085C YDR085C AFR1 hom Verified 0.692135524480984 0.244426112154346 no 1182 0.239077952987496 811 NA FT SIGNALING Protein required for pheromone-induced projection (shmoo) formation; regulates septin architecture during mating; has an RVXF motif that mediates targeting of Glc7p to mating projections; interacts with Cdc12p; AFR1 has a paralog, YER158C, that arose from the whole genome duplication regulation of G-protein coupled receptor protein signaling pathway|pheromone-dependent signal transduction involved in conjugation with cellular fusion|cell morphogenesis involved in conjugation with cellular fusion|cell morphogenesis involved in conjugation receptor signaling protein activity mating projection base
YPR099C_d YPR099C YPR099C hom Dubious 0.691897138986955 0.244500963736628 no 1183 0.238858068097199 830 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL51/YPR100W Unknown Unknown Unknown
YDR350C YDR350C ATP22 hom Verified 0.691109314602957 0.244748423574852 no 1184 0.254337913218466 887 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Specific translational activator for the mitochondrial ATP6 mRNA, encoding a subunit of F1F0 ATP synthase; localized to the mitochondrial inner membrane proton-transporting ATP synthase complex biogenesis|positive regulation of mitochondrial translation translation regulator activity mitochondrial inner membrane
YDL198C YDL198C GGC1 hom Verified 0.691020187255961 0.244776427436979 no 1185 0.253067609265203 860 NA FT ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS MITOCHONDRION Mitochondrial GTP/GDP transporter, essential for mitochondrial genome maintenance; has a role in mitochondrial iron transport; member of the mitochondrial carrier family cellular iron ion homeostasis|mitochondrial genome maintenance|transmembrane transport|guanine nucleotide transport guanine nucleotide transmembrane transporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YDL077C YDL077C VAM6 hom Verified 0.690642025965849 0.244895265107998 no 1186 0.295511894642722 1005 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p regulation of SNARE complex assembly|regulation of vacuole fusion, non-autophagic|piecemeal microautophagy of nucleus|vesicle-mediated transport|vacuole organization|vacuole fusion, non-autophagic Rab guanyl-nucleotide exchange factor activity|phosphatidylinositol binding fungal-type vacuole membrane|HOPS complex|fungal-type vacuole
YGR228W_d YGR228W YGR228W hom Dubious 0.690412108977249 0.244967531991026 no 1187 0.268283208847961 940 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SMI1/YGR229C Unknown Unknown Unknown
YBR031W YBR031W RPL4A hom Verified 0.690215995267623 0.245029182985648 no 1188 0.236348652932726 846 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L4A; N-terminally acetylated; homologous to mammalian ribosomal protein L4 and bacterial L4; RPL4A has a paralog, RPL4B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YGL223C YGL223C COG1 hom Verified 0.68830515045824 0.245630319497611 no 1189 0.302965204929712 1011 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments retrograde transport, vesicle recycling within Golgi|intra-Golgi vesicle-mediated transport|CVT pathway molecular_function Golgi transport complex
YGL094C YGL094C PAN2 hom Verified 0.68810118471235 0.245694532244033 no 1190 0.258205593075144 909 NA FT RNA PROCESSING|RESPONSE TO DNA DAMAGE|PROTEOLYSIS Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes mRNA 3'-end processing|postreplication repair|mRNA processing poly(A)-specific ribonuclease activity PAN complex|cytoplasm
YNR057C YNR057C BIO4 hom Verified 0.686711141029074 0.246132387443284 no 1191 0.265314834790253 915 NA FT KETONE METABOLISM|COFACTOR METABOLISM Dethiobiotin synthetase, catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; expression appears to be repressed at low iron levels biotin biosynthetic process dethiobiotin synthase activity cytoplasm
YOR226C YOR226C ISU2 hom Verified 0.68526209233286 0.246589274011217 no 1192 0.238371047518414 838 NA FT RNA PROCESSING|ION HOMEOSTASIS|ION HOMEOSTASIS|COFACTOR METABOLISM MITOCHONDRION Protein required for synthesis of iron-sulfur proteins; localized to the mitochondrial matrix; performs a scaffolding function in mitochondria during Fe/S cluster assembly; involved in Fe-S cluster assembly for both mitochondrial and cytosolic proteins; isu1 isu2 double mutant is inviable; protein abundance increases in response to DNA replication stress; evolutionarily conserved cellular iron ion homeostasis|iron-sulfur cluster assembly|tRNA wobble uridine modification molecular_function mitochondrial matrix
YMR041C YMR041C ARA2 hom Verified 0.684190119990174 0.246927560136774 no 1193 0.237546184531752 786 NA FT OXIDATION-REDUCTION PROCESS NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase dehydro-D-arabinono-1,4-lactone biosynthetic process D-arabinose 1-dehydrogenase [NAD(P)+] activity cellular_component
YLR204W YLR204W QRI5 hom Verified 0.681756441222489 0.247696485856749 no 1194 0.294961172912615 1026 NA FF|FT RNA PROCESSING MITOCHONDRION Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA mRNA processing molecular_function mitochondrion|integral to mitochondrial inner membrane
YDR443C YDR443C SSN2 hom Verified 0.681157725969243 0.2478858469418 no 1195 0.257257989674886 879 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS NUCLEUS Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter by galactose RNA polymerase II transcription coactivator activity|RNA polymerase II transcription factor recruiting transcription factor activity mediator complex
YOR237W YOR237W HES1 hom Verified 0.680129804058234 0.248211137223067 no 1196 0.266187446213086 887 NA FT VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION Protein implicated in the regulation of ergosterol biosynthesis; one of a seven member gene family with a common essential function and non-essential unique functions; similar to human oxysterol binding protein (OSBP); HES1 has a paralog, KES1, that arose from the whole genome duplication maintenance of cell polarity|endocytosis|exocytosis|sterol transport lipid binding|oxysterol binding|sterol transporter activity cellular_component
YNL046W_p YNL046W YNL046W hom Uncharacterized 0.678154735094165 0.248836794576996 no 1197 0.232788061121589 788 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Putative protein of unknown function; expression depends on Swi5p; GFP-fusion protein localizes to the endoplasmic reticulum; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) biological_process molecular_function endoplasmic reticulum
YDL036C YDL036C PUS9 hom Verified 0.678011095572677 0.248882329068068 no 1198 0.229531301531354 740 NA FT RNA PROCESSING NUCLEUS|MITOCHONDRION Mitochondrial tRNA:pseudouridine synthase, catalyzes the formation of pseudouridine at position 32 in mitochondrial tRNAs; contains an N-terminal mitochondrial targeting sequence tRNA pseudouridine synthesis pseudouridine synthase activity mitochondrion|nucleus|cytoplasm
YDR142C YDR142C PEX7 hom Verified 0.677798479196786 0.248949737728661 no 1199 0.272753533157062 882 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PEROXISOME ORGANIZATION Peroxisomal signal receptor for the N-terminal nonapeptide signal (PTS2) of peroxisomal matrix proteins; WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodysplasia punctata (RCDP) protein import into peroxisome matrix, docking peroxisome matrix targeting signal-2 binding cytosol|peroxisome
YJL178C YJL178C ATG27 hom Verified 0.677512335304443 0.249040473152722 no 1200 0.243525107022089 839 NA FT PROTEIN LOCALIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION ENDOMEMBRANE SYSTEM|MITOCHONDRION|GOLGI APPARATUS Type I membrane protein involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; may be involved in membrane delivery to the phagophore assembly site vesicle organization|peroxisome degradation|protein localization to pre-autophagosomal structure|CVT pathway|autophagic vacuole assembly phosphatidylinositol-3-phosphate binding trans-Golgi network|mitochondrion|pre-autophagosomal structure|membrane
YIR004W YIR004W DJP1 hom Verified 0.677442279779372 0.249062690243743 no 1201 0.226688095702923 761 NA FT PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION Cytosolic J-domain-containing protein, required for peroxisomal protein import and involved in peroxisome assembly, homologous to E. coli DnaJ protein import into peroxisome matrix chaperone binding cytosol
YMR151W_d YMR151W YIM2 hom Dubious 0.676996989343881 0.249203932278722 no 1202 0.241619666414997 808 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1 Unknown Unknown Unknown
YKR082W YKR082W NUP133 hom Verified 0.676791245705835 0.249269206655111 no 1203 0.25213497974281 855 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP133 poly(A)+ mRNA export from nucleus|double-strand break repair|maintenance of chromatin silencing at telomere|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|tRNA export from nucleus|telomere tethering at nuclear periphery|nuclear pore distribution|mRNA export from nucleus in response to heat stress|positive regulation of transcription, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette structural constituent of nuclear pore integral to membrane|nuclear pore|nuclear pore outer ring
YNL194C YNL194C YNL194C hom Verified 0.675647745280966 0.249632160043435 no 1204 0.239326280616244 822 NA FT ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Integral membrane protein required for sporulation and plasma membrane sphingolipid content; has sequence similarity to SUR7 and FMP45; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; GFP-fusion protein is more abundant at MCCs (membrane compartment occupied by Can1) in the presence of glycerol and oleate ascospore formation molecular_function cell cortex|integral to membrane|endoplasmic reticulum|plasma membrane|cytoplasm
YKL131W_d YKL131W YKL131W hom Dubious 0.674347768269993 0.250045120690169 no 1205 0.211608646249916 707 NA Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YMR317W_p YMR317W YMR317W hom Uncharacterized 0.674012451508571 0.250151698752417 no 1206 0.24222228597155 860 NA Putative protein of unknown function with some similarity to sialidase from Trypanosoma; YMR317W is not an essential gene biological_process molecular_function cellular_component
YPL154C YPL154C PEP4 hom Verified 0.672977561102067 0.250480783231558 no 1207 0.261020626194571 903 NA FT MEMBRANE ORGANIZATION|PROTEOLYSIS|RESPONSE TO NUTRIENT LEVELS MITOCHONDRION Vacuolar aspartyl protease (proteinase A), required for the posttranslational precursor maturation of vacuolar proteinases; important for protein turnover after oxidative damage; synthesized as a zymogen, self-activates microautophagy|proteolysis involved in cellular protein catabolic process|cellular response to starvation peptidase activity fungal-type vacuole lumen|mitochondrion|fungal-type vacuole
YCR091W YCR091W KIN82 hom Verified 0.671757427736757 0.250869067552272 no 1208 0.22654659076238 799 NA FT MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION Putative serine/threonine protein kinase implicated in the regulation of phospholipid asymmetry through the activation of phospholipid translocases (flippases) Lem3p-Dnf1p/Dnf2p; similar to Fpk1p phospholipid translocation|protein phosphorylation|response to pheromone protein kinase activity cellular_component
YHR133C YHR133C NSG1 hom Verified 0.669503388181761 0.251587210055283 no 1209 0.24031615171455 836 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; homolog of mammalian INSIG proteins; forms foci at the nuclear periphery upon DNA replication stress sterol biosynthetic process unfolded protein binding integral to membrane|endoplasmic reticulum
YAL021C YAL021C CCR4 hom Verified 0.669333290556077 0.251641447609489 no 1210 0.301979191344336 1040 NA FF|FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RNA PROCESSING NUCLEUS RNA POL II, HOLOENZYME Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|DNA replication checkpoint|nuclear-transcribed mRNA poly(A) tail shortening|traversing start control point of mitotic cell cycle|replication fork protection|transcription elongation from RNA polymerase II promoter|DNA replication 3'-5'-exoribonuclease activity CCR4-NOT core complex|cytoplasmic mRNA processing body|Cdc73/Paf1 complex|cytoplasm
YOL019W-A_p YOL019W-A YOL019W-A hom Uncharacterized 0.667859407084069 0.252111670535029 no 1211 0.238299925814504 778 NA Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YPL180W YPL180W TCO89 hom Verified 0.667655254421761 0.252176839254954 no 1212 0.271281434620298 953 NA FT SIGNALING|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM PLASMA MEMBRANE Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p), a complex that regulates growth in response to nutrient availability; cooperates with Ssd1p in the maintenance of cellular integrity; deletion strains are hypersensitive to rapamycin TOR signaling cascade|fungal-type cell wall organization|response to salt stress|regulation of cell growth|glycerol metabolic process molecular_function TORC1 complex|fungal-type vacuole membrane|extrinsic to internal side of plasma membrane|extrinsic to vacuolar membrane
YGL262W_p YGL262W YGL262W hom Uncharacterized 0.667167010750105 0.252332730288416 no 1213 0.229052217108966 774 NA Putative protein of unknown function; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein; YGL262W is not an essential gene biological_process molecular_function cellular_component
YOL162W_p YOL162W YOL162W hom Uncharacterized 0.666643819497176 0.252499836085231 no 1214 0.233801679251177 787 NA Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family transmembrane transport transmembrane transporter activity integral to membrane|membrane
YOR215C YOR215C AIM41 hom Verified 0.666490232860674 0.252548902288878 no 1215 0.244942694811493 821 NA FT MITOCHONDRION Putative protein of unknown function; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss biological_process molecular_function mitochondrion
YER066W_p YER066W RRT13 hom Uncharacterized 0.665294460301326 0.252931086558564 no 1216 0.220161729455134 788 NA Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription biological_process molecular_function cellular_component
YJL055W_p YJL055W YJL055W hom Uncharacterized 0.664591244638798 0.253155985370455 no 1217 0.255951895609147 891 NA FT NUCLEUS Putative protein of unknown function, proposed to be involved in the metabolism of purine and pyrimidine base analogues; deletion mutants are sensitive to HAP and AHA; overexpression confers resistance to 5-FOA and 5-FU response to chemical stimulus|response to purine-containing compound molecular_function nucleus|cytoplasm
YNL294C YNL294C RIM21 hom Verified 0.660864400440792 0.254349638993459 no 1218 0.276331875455858 981 NA FF|FT ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS PLASMA MEMBRANE pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH fungal-type cell wall biogenesis|ascospore formation|invasive growth in response to glucose limitation molecular_function integral to membrane
YDL095W YDL095W PMT1 hom Verified 0.660830511012317 0.254360506800192 no 1219 0.283212588357801 975 NA FT PROTEIN LOCALIZATION|CARBOHYDRATE METABOLISM|PROTEOLYSIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein O-mannosyltransferase of the ER membrane; transfers mannose from dolichyl phosphate-D-mannose to protein serine and threonine residues; 1 of 7 related proteins involved in O-glycosylation which is essential for cell wall rigidity; involved in ER quality control; amino terminus faces cytoplasm, carboxyl terminus faces ER lumen ER-associated misfolded protein catabolic process|Unknown|protein exit from endoplasmic reticulum|protein O-linked mannosylation dolichyl-phosphate-mannose-protein mannosyltransferase activity integral to membrane|dolichyl-phosphate-mannose-protein mannosyltransferase complex
YGL016W YGL016W KAP122 hom Verified 0.659807286479421 0.254688753396784 no 1220 0.250256985963872 863 NA FT PROTEIN LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE Karyopherin beta, responsible for import of the Toa1p-Toa2p complex into the nucleus; binds to nucleoporins Nup1p and Nup2p; may play a role in regulation of pleiotropic drug resistance protein import into nucleus|regulation of cell size protein transporter activity integral to membrane|nuclear pore|cytoplasm
YDR051C YDR051C DET1 hom Verified 0.658590676997928 0.255079325633925 no 1221 0.242050791011165 794 NA FT NUCLEUS Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel intracellular sterol transport|dephosphorylation acid phosphatase activity nucleus|cytoplasm
YPL144W YPL144W POC4 hom Verified 0.658565163735902 0.255087519594967 no 1222 0.244903648152185 850 NA FT PROTEIN COMPLEX ORG/BIOGENESIS Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions proteasome assembly|chaperone-mediated protein complex assembly molecular_function intracellular|cytoplasm
YBR273C YBR273C UBX7 hom Verified 0.657831244276939 0.255323287604207 no 1223 0.235589452876756 789 NA FT PROTEOLYSIS ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p; UBX7 has a paralog, UBX6, that arose from the whole genome duplication sporulation resulting in formation of a cellular spore|ubiquitin-dependent protein catabolic process molecular_function nuclear envelope|endoplasmic reticulum
YOL052C YOL052C SPE2 hom Verified 0.655844056319449 0.255962233228339 no 1224 0.270420462885022 911 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM NUCLEUS S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically spermidine biosynthetic process|spermine biosynthetic process|pantothenate biosynthetic process adenosylmethionine decarboxylase activity nucleus|cytoplasm
YNL311C YNL311C SKP2 hom Verified 0.655683955092668 0.256013747275617 no 1225 0.248486742414781 829 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|PROTEOLYSIS UBIQUITIN LIGASE COMPLEX F-box protein of unknown function predicted to be part of an SCF ubiquitin protease complex; involved in regulating protein levels of sulfur metabolism enzymes; may interact with ribosomes, based on co-purification experiments SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular protein catabolic process|regulation of sulfur amino acid metabolic process ubiquitin-protein ligase activity|protein binding, bridging ribosome|SCF ubiquitin ligase complex
YPR166C YPR166C MRP2 hom Verified 0.654186410435942 0.256495857860532 no 1226 0.279793859175033 942 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YHR022C_p YHR022C YHR022C hom Uncharacterized 0.653972141288927 0.256564877047453 no 1227 0.243673053978171 856 NA FT SIGNALING Putative protein of unknown function; YHR022C is not an essential gene biological_process molecular_function cellular_component
YMR031C YMR031C EIS1 hom Verified 0.653100224036696 0.256845833926665 no 1228 0.267640280963987 884 NA FT PROTEIN COMPLEX ORG/BIOGENESIS MITOCHONDRION|PLASMA MEMBRANE Component of the eisosome required for proper eisosome assembly; similarity to Ykl050cp and Uso1p; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress eisosome assembly molecular_function eisosome|mitochondrion|membrane raft|cytoplasm
YER184C_p YER184C YER184C hom Uncharacterized 0.651793996802582 0.257267037429754 no 1229 0.267747000610414 942 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Putative zinc cluster protein; deletion confers sensitivity to Calcufluor white, and prevents growth on glycerol or lactate as sole carbon source biological_process sequence-specific DNA binding cellular_component
YDL020C YDL020C RPN4 hom Verified 0.651470264671476 0.257371482957026 no 1230 0.380040138009272 1240 NA FF|FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|PROTEOLYSIS NUCLEUS Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance|regulation of DNA repair|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YKR058W YKR058W GLG1 hom Verified 0.651032698459112 0.25751268972461 no 1231 0.24563568876092 854 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG1 has a paralog, GLG2, that arose from the whole genome duplication glycogen biosynthetic process glycogenin glucosyltransferase activity cellular_component
YJR090C YJR090C GRR1 hom Verified 0.649990490280503 0.257849182191903 no 1232 0.294105262214679 997 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CARBOHYDRATE METABOLISM|PROTEOLYSIS NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON UBIQUITIN LIGASE COMPLEX F-box protein component of the SCF ubiquitin-ligase complex; involved in carbon catabolite repression, glucose-dependent divalent cation transport, high-affinity glucose transport, morphogenesis, and sulfite detoxification SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular response to methylmercury|cell cycle arrest in response to pheromone|G1/S transition of mitotic cell cycle|response to DNA damage stimulus|protein ubiquitination ubiquitin-protein ligase activity|protein binding, bridging cellular bud neck contractile ring|SCF ubiquitin ligase complex|nucleus|cytoplasm
YML123C YML123C PHO84 hom Verified 0.649596953908045 0.257976300602528 no 1233 0.294784844957871 1014 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p; cells overexpressing Pho84p accumulate heavy metals but do not develop symptoms of metal toxicity phosphate ion transport|manganese ion transport|polyphosphate metabolic process manganese ion transmembrane transporter activity|inorganic phosphate transmembrane transporter activity integral to membrane|integral to plasma membrane
YNL024C_p YNL024C YNL024C hom Uncharacterized 0.64930501351493 0.258070622919683 no 1234 0.259744647067811 884 NA Putative methyltransferase; has seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; despite similarity to methyltransferases, null mutant does not display alterations in lysine methylation pattern biological_process S-adenosylmethionine-dependent methyltransferase activity cytoplasm
YOR338W_p YOR338W YOR338W hom Uncharacterized 0.647503909645523 0.258652932500585 no 1235 0.237893869441192 848 NA FT TRANSCRIPTION FROM RNA POL II Putative protein of unknown function; YOR338W transcription is regulated by Azf1p and its transcript is a specific target of the G protein effector Scp160p; identified as being required for sporulation in a high-throughput mutant screen; YOR338W has a paralog, FUN19, that arose from the whole genome duplication ascospore formation|positive regulation of transcription from RNA polymerase II promoter molecular_function cellular_component
YOR242C YOR242C SSP2 hom Verified 0.647503249345864 0.258653146104788 no 1236 0.240242956611435 811 NA FT CELL WALL ORG/BIOGENESIS Sporulation specific protein that localizes to the spore wall; required for sporulation at a point after meiosis II and during spore wall formation; SSP2 expression is induced midway in meiosis ascospore wall assembly|ascospore formation molecular_function ascospore wall
YHR046C YHR046C INM1 hom Verified 0.647276449816461 0.258726520215169 no 1237 0.271558336648368 933 NA FT LIPID METABOLISM|CARBOHYDRATE METABOLISM NUCLEUS Inositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate inositol phosphate dephosphorylation inositol monophosphate 1-phosphatase activity nucleus|cytoplasm
YBR251W YBR251W MRPS5 hom Verified 0.64675001138445 0.258896874924078 no 1238 0.299924819390859 1012 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YHR108W YHR108W GGA2 hom Verified 0.644166187845846 0.259733837031771 no 1239 0.253713989463435 902 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT GOLGI APPARATUS Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|Golgi to vacuole transport|Golgi to endosome transport ubiquitin binding|phosphatidylinositol-4-phosphate binding trans-Golgi network
YDR506C YDR506C GMC1 hom Verified 0.643667894202471 0.259895406699935 no 1240 0.245434864925526 818 NA FT CELL CYCLE|ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS Protein involved in meiotic progression; mutants are delayed in meiotic nuclear division and are defective in synaptonemal complex assembly; possible membrane-localized protein meiosis|synaptonemal complex organization molecular_function cellular_component
YDL130W-A YDL130W-A STF1 hom Verified 0.64353485860943 0.259938551711749 no 1241 0.275303748502907 975 NA FT NUCLEOTIDE METABOLISM MITOCHONDRION Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p act as stabilizing factors that enhance inhibitory action of the Inh1p protein; protein abundance increases in response to DNA replication stress negative regulation of ATPase activity molecular_function mitochondrion|mitochondrial proton-transporting ATP synthase complex
YML012W YML012W ERV25 hom Verified 0.643103354533038 0.260078518992071 no 1242 0.243615878916826 869 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Protein that forms a heterotrimeric complex with Erp1, Erp2p, and Emp24, member of the p24 family involved in endoplasmic reticulum to Golgi transport ER to Golgi vesicle-mediated transport molecular_function ER to Golgi transport vesicle
YKL096C-B_p YKL096C-B YKL096C-B hom Uncharacterized 0.642420655868864 0.260300045781013 no 1243 0.276080680945749 917 NA Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YER028C YER028C MIG3 hom Verified 0.64161064666186 0.2605630092225 no 1244 0.257164622569873 872 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Transcriptional regulator; partially nonfunctional in S288C strains but has a major role in catabolite repression and ethanol response in some other strains; involved in response to toxic agents; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes; MIG3 has a paralog, MIG2, that arose from the whole genome duplication cellular response to UV|negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|response to DNA damage stimulus RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding nuclear chromatin
YNL098C YNL098C RAS2 hom Verified 0.641269387766441 0.260673837308885 no 1245 0.313443511753753 1071 NA FT PROTEIN LOCALIZATION|SIGNALING|NUCLEOTIDE METABOLISM|RESPONSE TO NUTRIENT LEVELS PLASMA MEMBRANE GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes pseudohyphal growth|ascospore formation|activation of adenylate cyclase activity|regulation of protein localization|replicative cell aging|positive regulation of transcription by galactose|Ras protein signal transduction GTP binding|GTPase activity plasma membrane
YPL214C YPL214C THI6 hom Verified 0.641136122985513 0.260717123296146 no 1246 0.229559165853067 804 NA Bifunctional enzyme with thiamine-phosphate pyrophosphorylase and 4-methyl-5-beta-hydroxyethylthiazole kinase activities, required for thiamine biosynthesis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern thiamine biosynthetic process hydroxyethylthiazole kinase activity|thiamine-phosphate diphosphorylase activity cytosol|cytoplasm
YBR098W YBR098W MMS4 hom Verified 0.640654229472915 0.260873678910331 no 1247 0.250012951508538 876 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p DNA repair|DNA topological change|regulation of reciprocal meiotic recombination|reciprocal meiotic recombination|resolution of meiotic recombination intermediates|response to DNA damage stimulus transcription coactivator activity|endonuclease activity|crossover junction endodeoxyribonuclease activity Holliday junction resolvase complex|nucleus
YPR007C YPR007C REC8 hom Verified 0.640322654278588 0.260981427792697 no 1248 0.265583165952188 877 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p synaptonemal complex assembly|protein localization to chromosome, centromeric region|reciprocal meiotic recombination|meiotic sister chromatid cohesion molecular_function condensed nuclear chromosome|condensed nuclear chromosome, centromeric region
YEL046C YEL046C GLY1 hom Verified 0.639485620059296 0.261253532718922 no 1249 0.297708378808246 1003 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Threonine aldolase, catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis threonine catabolic process|glycine biosynthetic process threonine aldolase activity|L-allo-threonine aldolase activity cytosol
YPR130C_d YPR130C YPR130C hom Dubious 0.637268879536607 0.261974859127917 no 1250 0.265855505643766 908 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOR002W YOR002W ALG6 hom Verified 0.636411589017623 0.26225409464223 no 1251 0.310896105346301 1082 NA FT LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Alpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease oligosaccharide-lipid intermediate biosynthetic process|protein glycosylation|aerobic respiration transferase activity, transferring hexosyl groups|dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity integral to membrane|endoplasmic reticulum
YJL182C_d YJL182C YJL182C hom Dubious 0.636191107741751 0.262325934147485 no 1252 0.262365498250617 917 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YJL181W Unknown Unknown Unknown
YNR061C YNR061C YNR061C hom Verified 0.636008116991748 0.262385565752123 no 1253 0.247484520373821 855 NA Protein of unknown function; relocalizes from vacuole to cytoplasm upon DNA replication stress biological_process molecular_function integral to membrane|fungal-type vacuole
YGR125W_p YGR125W YGR125W hom Uncharacterized 0.633718503117734 0.263132273663823 no 1254 0.261080054472955 927 NA Putative protein of unknown function; deletion mutant has decreased rapamycin resistance but normal wormannin resistance; green fluorescent protein (GFP)-fusion protein localizes to the vacuole biological_process molecular_function integral to membrane|fungal-type vacuole
YOL073C YOL073C YOL073C hom Verified 0.632585329229427 0.263502234993398 no 1255 0.261708340403369 879 NA Subunit of the DSC ubiquitin ligase complex; ortholog of fission yeast dsc2 biological_process molecular_function integral to membrane
YPL260W YPL260W YPL260W hom Verified 0.631074408405539 0.263995936688722 no 1256 0.286649934285414 990 NA FT NUCLEUS Putative substrate of cAMP-dependent protein kinase (PKA); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YPL260W is not an essential gene; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus|cytoplasm
YML001W YML001W YPT7 hom Verified 0.630009293697566 0.264344251849626 no 1257 0.24964495464687 867 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|VACUOLAR TRANSPORT MITOCHONDRION Rab family GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion; interacts with the cargo selection/retromer complex for retrograde sorting; similar to mammalian Rab7 regulation of vacuole fusion, non-autophagic|piecemeal microautophagy of nucleus|vacuole inheritance|Golgi to vacuole transport|vesicle-mediated transport|endocytosis GTPase activity mitochondrial outer membrane|fungal-type vacuole
YDR129C YDR129C SAC6 hom Verified 0.629516479844828 0.264505491591279 no 1258 0.36893885080693 1214 NA FF|FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton; relocalizes from plasma membrane to cytoplasm upon DNA replication stress bipolar cellular bud site selection|actin filament organization|endocytosis|response to osmotic stress actin filament binding|protein binding, bridging actin filament bundle|mating projection tip|actin cortical patch
YKL085W YKL085W MDH1 hom Verified 0.629457426235087 0.264524816216982 no 1259 0.270112138855823 913 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated chronological cell aging|replicative cell aging|tricarboxylic acid cycle|aerobic respiration L-malate dehydrogenase activity|mRNA binding mitochondrion|mitochondrial matrix
YOL001W YOL001W PHO80 hom Verified 0.629365137317241 0.26455501815978 no 1260 0.293136056717367 1025 NA FF|FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CELL CYCLE|SIGNALING|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS|RESPONSE TO NUTRIENT LEVELS NUCLEUS Cyclin, interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling negative regulation of phosphate metabolic process|regulation of cyclin-dependent protein kinase activity|negative regulation of calcium-mediated signaling|negative regulation of transcription from RNA polymerase II promoter|cellular metal ion homeostasis|regulation of protein localization|negative regulation of macroautophagy cyclin-dependent protein kinase regulator activity cyclin-dependent protein kinase holoenzyme complex|nucleus
YFR012W-A_p YFR012W-A YFR012W-A hom Uncharacterized 0.629078840328518 0.264648721234504 no 1261 0.231344233584427 801 NA Putative protein of unknown function; identified by homology biological_process molecular_function cellular_component
YER073W YER073W ALD5 hom Verified 0.626487012462274 0.265497776468164 no 1262 0.271570998352344 953 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION Mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed acetate biosynthetic process aldehyde dehydrogenase [NAD(P)+] activity mitochondrion
YML097C YML097C VPS9 hom Verified 0.625398834440951 0.265854663466946 no 1263 0.258932969445126 897 NA FF|FT PROTEIN LOCALIZATION|VACUOLAR TRANSPORT A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin vacuole inheritance|protein targeting to vacuole ubiquitin binding|guanyl-nucleotide exchange factor activity cytosol
YMR025W YMR025W CSI1 hom Verified 0.62498738749195 0.265989667997871 no 1264 0.251638987875528 857 NA FT SIGNALING NUCLEUS Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling; functional equivalent of canonical Csn6 subunit of the COP9 signalosome adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|cullin deneddylation molecular_function signalosome
YNL286W YNL286W CUS2 hom Verified 0.62441988650781 0.266175934159081 no 1265 0.269878506154205 898 NA FT RNA PROCESSING NUCLEUS Protein that binds to U2 snRNA and Prp11p, may be involved in U2 snRNA folding; contains two RNA recognition motifs (RRMs) mRNA splicing, via spliceosome RNA binding U2 snRNP
YIL086C_d YIL086C YIL086C hom Dubious 0.622891442393654 0.266677930982358 no 1266 0.252327274580555 867 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOL011W YOL011W PLB3 hom Verified 0.622113397636345 0.266933652970635 no 1267 0.244079137031694 843 NA FT LIPID METABOLISM PLASMA MEMBRANE Phospholipase B (lysophospholipase) involved in phospholipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro phosphatidylinositol metabolic process|phosphatidylserine catabolic process lysophospholipase activity extracellular region|plasma membrane
YOR018W YOR018W ROD1 hom Verified 0.621844025167953 0.267022217175613 no 1268 0.253091846564295 850 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION PLASMA MEMBRANE Membrane protein, binds the ubiquitin ligase Rsp5p via its 2 PY motifs; overexpression confers resistance to the GST substrate o-dinitrobenzene, zinc, and calcium; proposed to regulate the endocytosis of plasma membrane proteins; protein abundance increases in response to DNA replication stress; ROD1 has a paralog, ROG3, that arose from the whole genome duplication response to drug|ubiquitin-dependent endocytosis ubiquitin protein ligase binding plasma membrane
YMR173W-A_d YMR173W-A YMR173W-A hom Dubious 0.621682831525697 0.26707522147204 no 1269 0.281932159068459 974 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene DDR48/YML173W Unknown Unknown Unknown
YER169W YER169W RPH1 hom Verified 0.620658482183978 0.267412175952671 no 1270 0.279582397847187 996 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS JmjC domain-containing histone demethylase; specifically demethylates H3K36 tri- and dimethyl modification states; associates with actively transcribed (RNA polymerase II) regions in vivo and specifically targets H3K36 in its trimethylation state as its substrate; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway; RPH1 has a paralog, GIS1, that arose from the whole genome duplication negative regulation of transcription from RNA polymerase II promoter|histone demethylation RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|sequence-specific DNA binding|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific) nucleus
YMR182C YMR182C RGM1 hom Verified 0.620442108857253 0.267483378273315 no 1271 0.26400379972093 902 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS|CHROMOSOME Putative zinc finger DNA binding transcription factor; contains two N-terminal C2H2 zinc fingers and C-terminal proline rich domain; overproduction impairs cell growth and induces expression of genes involved in monosaccharide catabolism and aldehyde metabolism; regulates expression of of Y-prime telomeric elements and subtelomeric COS genes; RGM1 has a paralog, USV1, that arose from the whole genome duplication positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity nuclear chromatin
YGR170W YGR170W PSD2 hom Verified 0.620020928347309 0.26762200423742 no 1272 0.270606745383121 878 NA FT LIPID METABOLISM GOLGI APPARATUS Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes, converts phosphatidylserine to phosphatidylethanolamine phosphatidylcholine biosynthetic process phosphatidylserine decarboxylase activity endosome
YGR201C_p YGR201C YGR201C hom Uncharacterized 0.619646446618349 0.267745290325884 no 1273 0.2476363708885 848 NA Putative protein of unknown function biological_process molecular_function cellular_component
YER113C YER113C TMN3 hom Verified 0.618713283224526 0.268052628874659 no 1274 0.26138722051998 926 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn2p; member of Transmembrane Nine family with 9 transmembrane segments; localizes to Golgi; induced by 8-methoxypsoralen plus UVA irradiation cellular copper ion homeostasis|vacuolar transport|pseudohyphal growth|invasive growth in response to glucose limitation molecular_function COPI-coated vesicle|integral to membrane|Golgi apparatus
YBR187W_p YBR187W GDT1 hom Uncharacterized 0.617973534631152 0.268296392146463 no 1275 0.270863303374977 952 NA Putative protein of unknown function; expression is reduced in a gcr1 null mutant; GFP-fusion protein localizes to the vacuole; expression pattern and physical interactions suggest a possible role in ribosome biogenesis biological_process molecular_function integral to membrane|fungal-type vacuole
YGR290W_d YGR290W YGR290W hom Dubious 0.617051055092991 0.268600525394875 no 1276 0.281347913258248 975 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; putative HLH protein; partially overlaps the verified ORF MAL11/YGR289C (a high-affinity maltose transporter) Unknown Unknown Unknown
YEL065W YEL065W SIT1 hom Verified 0.615884354149492 0.268985424238038 no 1277 0.245715442957232 850 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p cellular iron ion homeostasis|siderophore transport|transmembrane transport siderophore uptake transmembrane transporter activity endosome|integral to membrane|cytoplasmic membrane-bounded vesicle
YHL011C YHL011C PRS3 hom Verified 0.615846200730798 0.268998015861804 no 1278 0.286285949380719 989 NA FF|FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes fungal-type cell wall organization|5-phosphoribose 1-diphosphate biosynthetic process|regulation of cell size ribose phosphate diphosphokinase activity cytoplasm
YHR103W YHR103W SBE22 hom Verified 0.61530797982731 0.269175674324711 no 1279 0.272560860600959 930 NA FT PROTEIN LOCALIZATION|CELL WALL ORG/BIOGENESIS GOLGI APPARATUS Protein involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; involved in bud growth fungal-type cell wall organization molecular_function cytoplasm
YBL062W_d YBL062W YBL062W hom Dubious 0.614725151617108 0.269368123337053 no 1280 0.298296782930996 1030 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YJR130C YJR130C STR2 hom Verified 0.611302384318607 0.27049970640537 no 1281 0.262648785590029 897 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Cystathionine gamma-synthase, converts cysteine into cystathionine sulfur compound metabolic process|transsulfuration cystathionine gamma-synthase activity nucleus|cytoplasm
YGL101W_p YGL101W YGL101W hom Uncharacterized 0.609409943074054 0.271126374463918 no 1282 0.271682533446377 890 NA FT NUCLEUS Putative protein of unknown function; non-essential gene with similarity to YBR242W; interacts with the DNA helicase Hpr5p biological_process molecular_function nucleus|cytoplasm
YGR160W_d YGR160W YGR160W hom Dubious 0.609047183799479 0.271246582178461 no 1283 0.250948944921541 866 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPR044C_d YPR044C OPI11 hom Dubious 0.608390720572871 0.271464182230033 no 1284 0.271733565893631 925 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RPL43A/YPR043W; deletion confers sensitivity to GSAO Unknown Unknown Unknown
YDR380W YDR380W ARO10 hom Verified 0.607365740828772 0.271804109470826 no 1285 0.254996243686554 860 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Phenylpyruvate decarboxylase, catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde, which is the first specific step in the Ehrlich pathway L-phenylalanine catabolic process|methionine catabolic process to 3-methylthiopropanol|tryptophan catabolic process|branched-chain amino acid catabolic process to alcohol via Ehrlich pathway|aromatic amino acid family catabolic process to alcohol via Ehrlich pathway|leucine catabolic process pyruvate decarboxylase activity|carboxy-lyase activity|phenylpyruvate decarboxylase activity cytoplasm
YMR237W YMR237W BCH1 hom Verified 0.606073882124059 0.272232846726953 no 1286 0.279585631822537 955 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM GOLGI APPARATUS Member of the ChAPs family (Chs5p-Arf1p-binding proteins); members include Bch1p, Bch2p, Bud7p, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p to mediate export of specific cargo proteins from the Golgi to the plasma membrane; may interact with ribosomes; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress; BCH1 has a paralog, BUD7, that arose from the whole genome duplication Golgi to plasma membrane transport|fungal-type cell wall chitin biosynthetic process molecular_function ribosome|clathrin-coated vesicle|exomer complex
YPL253C YPL253C VIK1 hom Verified 0.605326557107746 0.272481019522558 no 1287 0.275670204796865 951 NA FT CELL CYCLE|CHROMOSOME SEGREGATION NUCLEUS|CYTOSKELETON Protein that forms a complex with Kar3p at the spindle pole body, possible regulator of Kar3p function in microtubule-mediated processes; required for sister chromatid cohesion; has similarity to Cik1p microtubule-based process|mitotic sister chromatid cohesion microtubule motor activity kinesin complex|spindle pole body
YLR099C YLR099C ICT1 hom Verified 0.603929540550466 0.27294524393727 no 1288 0.276783827043447 990 NA FT KETONE METABOLISM|LIPID METABOLISM Lysophosphatidic acid acyltransferase; responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stress; ICT1 has a paralog, ECM18, that arose from the whole genome duplication phosphatidic acid biosynthetic process lysophosphatidic acid acyltransferase activity cellular_component
YDR321W YDR321W ASP1 hom Verified 0.603836560800639 0.272976154743 no 1289 0.265907336412536 914 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Cytosolic L-asparaginase, involved in asparagine catabolism; catalyzes hydrolysis of L-asparagine to aspartic acid and ammonia, has an important role in therapy of acute lymphoblastic leukemia; synthesized constitutively asparagine catabolic process asparaginase activity intracellular
YML088W YML088W UFO1 hom Verified 0.603666146423989 0.2730328129358 no 1290 0.263739697030111 900 NA FT RESPONSE TO DNA DAMAGE|PROTEOLYSIS NUCLEUS UBIQUITIN LIGASE COMPLEX F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular response to methylmercury|response to DNA damage stimulus ubiquitin-protein ligase activity|protein binding, bridging SCF ubiquitin ligase complex|nucleus|cytoplasm
YOR042W YOR042W CUE5 hom Verified 0.603089752941971 0.273224491445294 no 1291 0.278959774006958 948 NA Protein containing a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern biological_process ubiquitin binding cytoplasm
YAL013W YAL013W DEP1 hom Verified 0.602313176351691 0.273482845822117 no 1292 0.280754752394036 972 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Transcriptional modulator involved in regulation of structural phospholipid biosynthesis genes and metabolically unrelated genes, as well as maintenance of telomeres, mating efficiency, and sporulation positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of chromatin silencing at rDNA|regulation of transcription from RNA polymerase II promoter|histone deacetylation|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of chromatin silencing at telomere|negative regulation of transcription from RNA polymerase II promoter|regulation of DNA-dependent DNA replication initiation|Unknown molecular_function Rpd3L-Expanded complex|Rpd3L complex
YLR278C_p YLR278C YLR278C hom Uncharacterized 0.602250211895801 0.273503798369283 no 1293 0.285648889955751 965 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Zinc-cluster protein; GFP-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; has a prion-domain like fragment that increases frequency of [URE3]; YLR278C is not an essential gene biological_process sequence-specific DNA binding nucleus
YLR144C YLR144C ACF2 hom Verified 0.602194352061742 0.273522387391779 no 1294 0.269231855065708 938 NA FT CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION Intracellular beta-1,3-endoglucanase; expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly; protein abundance increases in response to DNA replication stress actin cytoskeleton organization glucan endo-1,3-beta-D-glucosidase activity intracellular
YMR285C YMR285C NGL2 hom Verified 0.599877080716184 0.274294078989967 no 1295 0.250595966355758 835 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p; NGL2 has a paralog, NGL3, that arose from the whole genome duplication rRNA processing endoribonuclease activity intracellular
YCL023C_d YCL023C YCL023C hom Dubious 0.598723312468581 0.274678704311664 no 1296 0.263313013274913 880 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF KCC4 Unknown Unknown Unknown
YPR043W YPR043W RPL43A hom Verified 0.597440788031833 0.275106564288109 no 1297 0.220593574064711 744 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L43A; null mutation confers a dominant lethal phenotype; homologous to mammalian ribosomal protein L37A, no bacterial homolog; RPL43A has a paralog, RPL43B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YGR087C YGR087C PDC6 hom Verified 0.597280281479709 0.275160133603324 no 1298 0.277263837760164 923 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation L-phenylalanine catabolic process|ethanol metabolic process|tryptophan catabolic process|aromatic amino acid family catabolic process to alcohol via Ehrlich pathway pyruvate decarboxylase activity cytoplasm
YGR257C YGR257C MTM1 hom Verified 0.597072646191044 0.275229439827834 no 1299 0.304122423502869 1055 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor manganese ion transport|transport transporter activity|metallochaperone activity mitochondrion|integral to membrane|mitochondrial inner membrane
YLR050C_p YLR050C YLR050C hom Uncharacterized 0.596329467933164 0.275477574419818 no 1300 0.268719852260521 936 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLR050C is not an essential gene biological_process molecular_function integral to membrane|endoplasmic reticulum
YDR223W YDR223W CRF1 hom Verified 0.595968580051176 0.275598108431506 no 1301 0.275490913222263 938 NA FT TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS NUCLEUS|CHROMOSOME Transcriptional corepressor involved in repression of ribosomal protein (RP) gene transcription via the TOR signaling pathway which promotes accumulation of Crf1p in the nucleus; role in repression of RP genes varies by strain negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter transcription corepressor activity nuclear chromatin|nucleus|cytoplasm
YOL038C-A_p YOL038C-A YOL038C-A hom Uncharacterized 0.595818197295098 0.275648342866724 no 1302 0.248482857277133 822 NA Putative protein of unknown function; identified by SAGE analysis biological_process molecular_function cellular_component
YER064C YER064C VHR2 hom Verified 0.592819082574176 0.276651117763243 no 1303 0.256309014022328 873 NA FT NUCLEUS Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress regulation of transcription, DNA-dependent molecular_function nucleus
YDR034C YDR034C LYS14 hom Verified 0.59269817410954 0.276691581809754 no 1304 0.282485621250737 960 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer Unknown|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YFL001W YFL001W DEG1 hom Verified 0.5912054777875 0.277191376452744 no 1305 0.303054332188931 1010 NA FT RNA PROCESSING NUCLEUS tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm; non-essential for viability tRNA pseudouridine synthesis pseudouridine synthase activity nucleus|cytoplasm
YKR019C YKR019C IRS4 hom Verified 0.590554543095839 0.277409465004076 no 1306 0.39543328004516 1308 NA FF|FT LIPID METABOLISM|SIGNALING|CELL WALL ORG/BIOGENESIS|RESPONSE TO NUTRIENT LEVELS|GENE SILENCING MITOCHONDRION EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication autophagy|fungal-type cell wall organization|chromatin silencing at rDNA|inositol lipid-mediated signaling|CVT pathway|cellular response to starvation molecular_function mitochondrion|pre-autophagosomal structure
YOR274W YOR274W MOD5 hom Verified 0.588301979385239 0.278164808618935 no 1307 0.283467764356269 972 NA FT RNA PROCESSING NUCLEUS|MITOCHONDRION Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase; required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms; converts to a prion form, and prion conversion contributes to azole antifungal resistance by upregulating ergosterol biosynthesis tRNA modification tRNA dimethylallyltransferase activity cytosol|mitochondrion|nucleolus|nucleus
YGR044C YGR044C RME1 hom Verified 0.588141166507156 0.278218771725309 no 1308 0.213152533468639 733 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CELL DIVISION NUCLEUS Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-alpha2 regulator; mediates cell type control of sporulation; relocalizes from nucleus to cytoplasm upon DNA replication stress negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription during meiosis|negative regulation of meiosis|positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription involved in G1/S phase of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity nucleus
YMR069W YMR069W NAT4 hom Verified 0.586685332933697 0.278707530060016 no 1309 0.299705560694786 1028 NA FT CHROMATIN ORGANIZATION NUCLEUS N alpha-acetyl-transferase, involved in acetylation of the N-terminal residues of histones H4 and H2A histone acetylation histone acetyltransferase activity nucleus|cytoplasm
YDR094W_d YDR094W YDR094W hom Dubious 0.586575903286646 0.278744285107969 no 1310 0.251081040422644 852 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2 Unknown Unknown Unknown
YDR058C YDR058C TGL2 hom Verified 0.586420500942197 0.278796485443359 no 1311 0.285078008828679 997 NA FT PROTEIN LOCALIZATION|LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION Triacylglycerol lipase that is localized to the mitochondria; has lipolytic activity towards triacylglycerols and diacylglycerols when expressed in E. coli triglyceride catabolic process triglyceride lipase activity mitochondrion
YBR263W YBR263W SHM1 hom Verified 0.586097037232881 0.278905153590653 no 1312 0.236498490192815 786 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Mitochondrial serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine serine family amino acid biosynthetic process|one-carbon metabolic process glycine hydroxymethyltransferase activity mitochondrion
YLR334C_d YLR334C YLR334C hom Dubious 0.585829039910819 0.278995203324112 no 1313 0.252587585617694 841 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps a stand-alone long terminal repeat sequence whose presence indicates a retrotransposition event occurred here Unknown Unknown Unknown
YOR170W_d YOR170W YOR170W hom Dubious 0.585747114677829 0.279022733829299 no 1314 0.280357169091712 959 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene LCB4 Unknown Unknown Unknown
YPR057W YPR057W BRR1 hom Verified 0.585445956052741 0.279123947813669 no 1315 0.223651423445874 784 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING NUCLEUS snRNP protein component of spliceosomal snRNPs, required for pre-mRNA splicing and snRNP biogenesis; in null mutant newly-synthesized snRNAs are destabilized and 3'-end processing is slowed spliceosomal complex assembly RNA binding small nuclear ribonucleoprotein complex
YMR080C YMR080C NAM7 hom Verified 0.584900902111332 0.279307175992031 no 1316 0.295875402649764 1005 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|RNA LOCALIZATION|GENE SILENCING NUCLEUS ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance; forms cytoplasmic foci upon DNA replication stress nuclear-transcribed mRNA catabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|intracellular mRNA localization|translational frameshifting|regulation of translational termination|chromatin silencing at silent mating-type cassette|protein ubiquitination RNA-dependent ATPase activity|ATP-dependent RNA helicase activity|nucleic acid binding mitochondrion|polysome|cytoplasm
YNL202W YNL202W SPS19 hom Verified 0.584652196103681 0.279390801715156 no 1317 0.29977010499344 1050 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate fatty acid catabolic process|ascospore formation 2,4-dienoyl-CoA reductase (NADPH) activity peroxisomal matrix
YFR041C YFR041C ERJ5 hom Verified 0.584412165004228 0.279471522090514 no 1318 0.262588025200373 913 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Type I membrane protein with a J domain is required to preserve the folding capacity of the endoplasmic reticulum; loss of the non-essential ERJ5 gene leads to a constitutively induced unfolded protein response protein folding molecular_function endoplasmic reticulum
YDR057W YDR057W YOS9 hom Verified 0.582749356015157 0.280031021097068 no 1319 0.275215303737393 913 NA FT PROTEOLYSIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM UBIQUITIN LIGASE COMPLEX ER quality-control lectin; integral subunit of the HRD ligase; binds to glycans with terminal alpha-1,6 linked mannose on misfolded N-glycosylated proteins and participates in targeting proteins to ERAD; member of the OS-9 protein family ER-associated protein catabolic process oligosaccharide binding luminal surveillance complex|Hrd1p ubiquitin ligase ERAD-L complex|endoplasmic reticulum lumen
YDR279W YDR279W RNH202 hom Verified 0.580682338427624 0.280727283603702 no 1320 0.260133074606059 906 NA FT NUCLEUS Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS2 that causes Aicardi-Goutieres syndrome RNA catabolic process|DNA replication, removal of RNA primer ribonuclease H activity ribonuclease H2 complex|nucleus
YER121W_p YER121W YER121W hom Uncharacterized 0.580048980688032 0.28094079382752 no 1321 0.304694090815874 1020 NA Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy biological_process molecular_function cellular_component
YDL184C YDL184C RPL41A hom Verified 0.579077547976681 0.281268424395273 no 1322 0.272656951020308 895 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L41A; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41A has a paralog, RPL41B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YCR046C YCR046C IMG1 hom Verified 0.578568810596205 0.281440077439473 no 1323 0.282756611856163 965 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit, required for respiration and for maintenance of the mitochondrial genome mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YKL113C YKL113C RAD27 hom Verified 0.577913560159464 0.281661239896112 no 1324 0.308325135593859 1069 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION 5' to 3' exonuclease, 5' flap endonuclease, required for Okazaki fragment processing and maturation as well as for long-patch base-excision repair; member of the S. pombe RAD2/FEN1 family double-strand break repair via nonhomologous end joining|replicative cell aging|DNA replication, removal of RNA primer|base-excision repair, base-free sugar-phosphate removal|gene conversion at mating-type locus, DNA repair synthesis 5'-3' exonuclease activity|5'-flap endonuclease activity mitochondrion|nucleus
YLL006W YLL006W MMM1 hom Verified 0.577589532260851 0.281770637901576 no 1325 0.318128520604152 1076 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION ER integral membrane protein, component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth mitochondrion organization|mitochondrial genome maintenance|protein import into mitochondrial outer membrane|phospholipid transport molecular_function mitochondrial outer membrane|mitochondrion|integral to endoplasmic reticulum membrane|ERMES complex
YBR196C-A_p YBR196C-A YBR196C-A hom Uncharacterized 0.576451484862633 0.282155026632796 no 1326 0.317896780391017 1068 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YDR273W YDR273W DON1 hom Verified 0.576409098693446 0.282169347928459 no 1327 0.254966375717469 901 NA FT CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION Meiosis-specific component of the spindle pole body, part of the leading edge protein (LEP) coat, forms a ring-like structure at the leading edge of the prospore membrane during meiosis II meiosis|ascospore wall assembly molecular_function prospore membrane
YPR121W YPR121W THI22 hom Verified 0.575706984174375 0.282406626899718 no 1328 0.250928745207396 853 NA Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis thiamine biosynthetic process phosphomethylpyrimidine kinase activity|hydroxymethylpyrimidine kinase activity cellular_component
YGR200C YGR200C ELP2 hom Verified 0.574015244258258 0.282978742775617 no 1329 0.299725530168692 1006 NA FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin regulation of transcription from RNA polymerase II promoter|protein urmylation|tRNA wobble uridine modification molecular_function Elongator holoenzyme complex|nucleus|cytoplasm
YPR031W YPR031W NTO1 hom Verified 0.573763454073345 0.28306394121475 no 1330 0.310052424596405 1044 NA FT CHROMATIN ORGANIZATION NUCLEUS HISTONE ACETYLTRANSFERASE Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3 histone acetylation histone acetyltransferase activity|methylated histone residue binding nucleus|NuA3 histone acetyltransferase complex|cytoplasm
YEL050C YEL050C RML2 hom Verified 0.572689155537596 0.283427590695581 no 1331 0.318179639956643 1066 NA FF|FT KETONE METABOLISM|LIPID METABOLISM|TRANSLATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor cytoplasmic translation|fatty acid metabolic process structural constituent of ribosome mitochondrial large ribosomal subunit
YIR024C YIR024C YIR024C hom Verified 0.571903811906445 0.283693570713555 no 1332 0.296180746211781 1005 NA FT MITOCHONDRION Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; interacts with Arh1p, a mitochondrial oxidoreductase; deletion mutant has a respiratory growth defect biological_process molecular_function mitochondrion
YBR052C YBR052C RFS1 hom Verified 0.571151488592218 0.283948479477861 no 1333 0.243845490449261 835 NA FT OXIDATION-REDUCTION PROCESS Protein of unknown function; member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; RFS1 has a paralog, PST2, that arose from the whole genome duplication biological_process molecular_function membrane raft|cytoplasm
YKR020W YKR020W VPS51 hom Verified 0.570910366484795 0.284030201766878 no 1334 0.315071689748689 1072 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL DIVISION|VACUOLAR TRANSPORT GOLGI APPARATUS Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; links the (VFT/GARP) complex to the SNARE Tlg1p vesicle organization|retrograde transport, endosome to Golgi|budding cell apical bud growth|regulation of cell size|protein targeting to vacuole protein binding Golgi apparatus|GARP complex
YCR028C-A YCR028C-A RIM1 hom Verified 0.570816089266872 0.284062157724262 no 1335 0.322756754670787 1084 NA FT MITOCHONDRION ORGANIZATION MITOCHONDRION Single-stranded DNA-binding protein essential for mitochondrial genome maintenance; involved in mitochondrial DNA replication mitochondrial DNA replication|mitochondrial genome maintenance single-stranded DNA binding mitochondrial nucleoid|mitochondrion
YLR392C YLR392C ART10 hom Verified 0.569765009233653 0.284418545465176 no 1336 0.246802463828232 860 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION Protein of unknown function that contains 2 PY motifs and is ubiquinated by Rsp5p; overexpression confers resistance to arsenite; green fluorescent protein (GFP)-fusion protein localizes it to the cytoplasm; non-essential gene biological_process molecular_function cytoplasm
YKL039W YKL039W PTM1 hom Verified 0.569118430200668 0.28463788588627 no 1337 0.273310303471974 934 NA FT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Protein of unknown function; copurifies with late Golgi vesicles containing the v-SNARE Tlg2p; PTM1 has a paralog, YHL017W, that arose from the whole genome duplication biological_process molecular_function integral to membrane
YMR269W YMR269W TMA23 hom Verified 0.569085787157328 0.284648961598538 no 1338 0.284748678683223 983 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS NUCLEUS Nucleolar protein implicated in ribosome biogenesis; deletion extends chronological lifespan ribosomal small subunit biogenesis molecular_function ribosome|nucleolus
YBR076W YBR076W ECM8 hom Verified 0.567864900068267 0.285063353568103 no 1339 0.294908403724973 971 NA FT CELL WALL ORG/BIOGENESIS Non-essential protein of unknown function fungal-type cell wall organization molecular_function cellular_component
YEL025C_p YEL025C YEL025C hom Uncharacterized 0.566675629770116 0.285467290539053 no 1340 0.249657243014616 843 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus biological_process molecular_function nucleus|cytoplasm
YGR143W YGR143W SKN1 hom Verified 0.565426738229169 0.285891771061347 no 1341 0.30668683772984 1026 NA FT LIPID METABOLISM|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM Protein involved in sphingolipid biosynthesis; type II membrane protein with similarity to Kre6p fungal-type cell wall organization|(1->6)-beta-D-glucan biosynthetic process|sphingolipid biosynthetic process glucosidase activity integral to membrane
YDL065C YDL065C PEX19 hom Verified 0.565340768542446 0.28592100197472 no 1342 0.285991075227478 977 NA FT PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Chaperone and import receptor for newly-synthesized class I PMPs; binds peroxisomal membrane proteins (PMPs) in the cytoplasm and delivers them to the peroxisome for subsequent insertion into the peroxisomal membrane; interacts with Myo2p and contributes to peroxisome partitioning protein stabilization|protein import into peroxisome membrane|peroxisome inheritance|ER-dependent peroxisome organization|protein exit from endoplasmic reticulum peroxisome membrane targeting sequence binding|protein binding cytosol|peroxisomal membrane|endoplasmic reticulum
YOL131W_p YOL131W YOL131W hom Uncharacterized 0.564980993078334 0.286043346149616 no 1343 0.285668174002153 989 NA Putative protein of unknown function biological_process molecular_function cellular_component
YIL160C YIL160C POT1 hom Verified 0.563443047253985 0.2865666156992 no 1344 0.275462995462243 933 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids fatty acid beta-oxidation mRNA binding|acetyl-CoA C-acyltransferase activity peroxisomal matrix|peroxisome
YOR271C_p YOR271C FSF1 hom Uncharacterized 0.562754981256662 0.286800869691311 no 1345 0.272332848234896 928 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis biological_process molecular_function mitochondrion|integral to membrane
YLR436C YLR436C ECM30 hom Verified 0.560190810941463 0.287674647058068 no 1346 0.304775800892432 1048 NA FT CELL WALL ORG/BIOGENESIS Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants have abormal relative levels of mannose and glucose and have Gap1p sorting and transport defects; (GFP)-fusion protein localizes to the cytoplasm fungal-type cell wall organization molecular_function cytoplasm
YCL016C YCL016C DCC1 hom Verified 0.559448987591444 0.287927668296941 no 1347 0.302725260748724 1022 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION CHROMOSOME Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C, required for sister chromatid cohesion and telomere length maintenance maintenance of DNA trinucleotide repeats|response to DNA damage stimulus|mitotic sister chromatid cohesion molecular_function Ctf18 RFC-like complex
YKR097W YKR097W PCK1 hom Verified 0.558643224074602 0.288202617254072 no 1348 0.287592104567567 1018 NA FT CARBOHYDRATE METABOLISM Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol gluconeogenesis phosphoenolpyruvate carboxykinase (ATP) activity cytosol
YMR305C YMR305C SCW10 hom Verified 0.55780245443644 0.288489643248806 no 1349 0.291529068023276 962 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM ENDOPLASMIC RETICULUM Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p conjugation with cellular fusion glucosidase activity fungal-type cell wall|extracellular region|endoplasmic reticulum|cytoplasm
YOR135C_d YOR135C IRC14 hom Dubious 0.557109829938434 0.288726195893007 no 1350 0.266034615253289 913 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YOR136W; null mutant displays increased levels of spontaneous Rad52 foci Unknown Unknown Unknown
YPL165C YPL165C SET6 hom Verified 0.556707208338523 0.288863745561268 no 1351 0.272623337693819 906 NA SET domain protein of unknown function; deletion heterozygote is sensitive to compounds that target ergosterol biosynthesis, may be involved in compound availability biological_process molecular_function cellular_component
YGR069W_d YGR069W YGR069W hom Dubious 0.556118663244951 0.289064868695303 no 1352 0.303371734662355 1028 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YBL086C_p YBL086C YBL086C hom Uncharacterized 0.555196189124932 0.289380237630394 no 1353 0.271937689903687 922 NA Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery biological_process molecular_function cellular_component
YOR297C YOR297C TIM18 hom Verified 0.555168702556991 0.289389637023646 no 1354 0.262180118610379 895 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS MITOCHONDRION Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex cellular response to oxidative stress|protein import into mitochondrial inner membrane|apoptotic process|response to acid|response to osmotic stress|response to arsenic-containing substance protein channel activity mitochondrion|integral to membrane|mitochondrial inner membrane protein insertion complex
YLR172C YLR172C DPH5 hom Verified 0.554034241201366 0.28977770606836 no 1355 0.304474987939686 1026 NA Methyltransferase required for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); not essential for viability; GFP-Dph5p fusion protein localizes to the cytoplasm peptidyl-diphthamide biosynthetic process from peptidyl-histidine diphthine synthase activity cytoplasm
YKL166C YKL166C TPK3 hom Verified 0.553955104972869 0.289804785574111 no 1356 0.265352265715986 914 NA FT SIGNALING|MITOCHONDRION ORGANIZATION|PROTEIN PHOSPHORYLATION NUCLEUS cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication protein phosphorylation|mitochondrion organization|Ras protein signal transduction cAMP-dependent protein kinase activity|protein kinase activity cAMP-dependent protein kinase complex|nucleus|cytoplasm
YEL052W YEL052W AFG1 hom Verified 0.553705235575242 0.289890295794721 no 1357 0.277936096207926 942 NA FT PROTEIN LOCALIZATION|PROTEOLYSIS|RESPONSE TO OXIDATIVE STRESS|PEROXISOME ORGANIZATION MITOCHONDRION Conserved protein that may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain protein import into peroxisome matrix|cellular response to oxidative stress|misfolded or incompletely synthesized protein catabolic process molecular_function mitochondrion|mitochondrial inner membrane
YJL161W_p YJL161W FMP33 hom Uncharacterized 0.553527243726006 0.289951215321124 no 1358 0.270233241249666 919 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YOR198C YOR198C BFR1 hom Verified 0.553433872205124 0.289983175077103 no 1359 0.324506371137731 1097 NA FT CELL CYCLE ENDOMEMBRANE SYSTEM Component of mRNP complexes associated with polyribosomes; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity meiosis|mRNA metabolic process|regulation of mitosis RNA binding ribonucleoprotein complex|polysome|nuclear outer membrane-endoplasmic reticulum membrane network
YNL292W YNL292W PUS4 hom Verified 0.552893414849689 0.290168198455293 no 1360 0.293456395845306 1022 NA FT RNA PROCESSING NUCLEUS|MITOCHONDRION Pseudouridine synthase, catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs; PUS4 overexpression leads to translational derepression of GCN4 (Gcd- phenotype) tRNA modification pseudouridine synthase activity mitochondrion|nucleus
YJL160C_p YJL160C YJL160C hom Uncharacterized 0.55240797086094 0.290334435371797 no 1361 0.320811635199909 1120 NA Putative protein of unknown function; member of the PIR (proteins with internal repeats) family of cell wall proteins; non-essential gene that is required for sporulation; mRNA is weakly cell cycle regulated, peaking in mitosis; YJL160C has a paralog, PIR1, that arose from the whole genome duplication biological_process molecular_function cellular_component
YBR020W YBR020W GAL1 hom Verified 0.551800103653766 0.29054265813238 no 1362 0.279491264035357 985 NA FT CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; GAL1 has a paralog, GAL3, that arose from the whole genome duplication galactose catabolic process via UDP-galactose|carbohydrate phosphorylation|positive regulation of transcription by galactose galactokinase activity cytoplasm
YFR036W YFR036W CDC26 hom Verified 0.551107877825047 0.290779862705234 no 1363 0.33735019274182 1163 NA FF|FT CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION|PROTEOLYSIS NUCLEUS UBIQUITIN LIGASE COMPLEX Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition chromatin assembly|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination ubiquitin-protein ligase activity anaphase-promoting complex
YJL075C_d YJL075C APQ13 hom Dubious 0.548942866774514 0.291522329478664 no 1364 0.293006150894713 994 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene NET1; null mutant is sensitive to sorbate Unknown Unknown Unknown
YML003W_p YML003W YML003W hom Uncharacterized 0.548406619168687 0.29170636623074 no 1365 0.273332310670722 916 NA Putative protein of unknown function biological_process molecular_function cellular_component
YNL257C YNL257C SIP3 hom Verified 0.548368592603031 0.291719418760878 no 1366 0.326080921895213 1095 NA FT TRANSCRIPTION FROM RNA POL II Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog, YSP1, that arose from the whole genome duplication positive regulation of transcription from RNA polymerase II promoter transcription cofactor activity integral to membrane
YGL012W YGL012W ERG4 hom Verified 0.547548796131271 0.292000878154204 no 1367 0.404449118649921 1351 NA FF|FT LIPID METABOLISM|OXIDATION-REDUCTION PROCESS ENDOPLASMIC RETICULUM C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol ergosterol biosynthetic process delta24(24-1) sterol reductase activity integral to membrane|endoplasmic reticulum
YNR018W YNR018W RCF2 hom Verified 0.54724284843552 0.292105951068325 no 1368 0.28590052332014 944 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast mitochondrial respiratory chain complex IV assembly molecular_function mitochondrion|mitochondrial respiratory chain supercomplex|mitochondrial respiratory chain complex IV|integral to mitochondrial inner membrane
YBR006W YBR006W UGA2 hom Verified 0.54692457004017 0.29221527743828 no 1369 0.35593714230816 1181 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm cellular response to oxidative stress|gamma-aminobutyric acid catabolic process|glutamate decarboxylation to succinate succinate-semialdehyde dehydrogenase [NAD(P)+] activity cytoplasm
YKR057W YKR057W RPS21A hom Verified 0.545312261614815 0.292769386186751 no 1370 0.287494951777333 1000 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21A has a paralog, RPS21B, that arose from the whole genome duplication cytoplasmic translation|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit
YJL116C YJL116C NCA3 hom Verified 0.544572045232729 0.29302394274068 no 1371 0.279952687529188 959 NA FT MITOCHONDRION ORGANIZATION MITOCHONDRION Protein involved in mitochondrion organization; functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; member of the SUN family; expression induced in cells treated with the mycotoxin patulin; NCA3 has a paralog, UTH1, that arose from the whole genome duplication mitochondrion organization molecular_function cellular_component
YBL009W YBL009W ALK2 hom Verified 0.544154665293987 0.293167522782364 no 1372 0.284090233868408 974 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; ALK2 has a paralog, ALK1, that arose from the whole genome duplication; similar to mammalian haspins meiosis|mitosis|protein phosphorylation protein serine/threonine kinase activity|protein kinase activity cellular_component
YCR019W YCR019W MAK32 hom Verified 0.544063205459906 0.293198989616415 no 1373 0.290804648613208 1015 NA Protein necessary for structural stability of L-A double-stranded RNA-containing particles interspecies interaction between organisms molecular_function cellular_component
YOR139C_d YOR139C YOR139C hom Dubious 0.543100236962435 0.29353039474955 no 1374 0.321519333582134 1106 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SFL1/YOR140W Unknown Unknown Unknown
YOR184W YOR184W SER1 hom Verified 0.541739138599961 0.29399911172654 no 1375 0.301713572298909 1034 NA FT KETONE METABOLISM|AMINO ACID METABOLISM 3-phosphoserine aminotransferase; catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p; protein abundance increases in response to DNA replication stress serine family amino acid biosynthetic process|L-serine biosynthetic process|purine nucleobase biosynthetic process O-phospho-L-serine:2-oxoglutarate aminotransferase activity cytoplasm
YML101C-A_d YML101C-A YML101C-A hom Dubious 0.540682555195625 0.294363202284189 no 1376 0.289581026289929 955 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YNL252C YNL252C MRPL17 hom Verified 0.539347124179692 0.294823679223859 no 1377 0.292140455465645 998 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YGL056C YGL056C SDS23 hom Verified 0.539069925325505 0.294919303209242 no 1378 0.295385362562921 1011 NA FT CELL DIVISION NUCLEUS One of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; involved in cell separation during budding; SDS23 has a paralog, SDS24, that arose from the whole genome duplication cytokinetic cell separation molecular_function nucleus|cytoplasm
YER060W YER060W FCY21 hom Verified 0.538930455028603 0.294967421025884 no 1379 0.288568522166495 995 NA Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function transmembrane transport nucleobase transmembrane transporter activity integral to membrane
YOL062C YOL062C APM4 hom Verified 0.538574897526435 0.295090106164688 no 1380 0.278657436419981 954 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|PLASMA MEMBRANE Mu2-like subunit of the clathrin associated protein complex (AP-2); involved in vesicle transport intracellular protein transport|vesicle-mediated transport molecular_function AP-2 adaptor complex
YGR284C YGR284C ERV29 hom Verified 0.538030045931329 0.295278152827316 no 1381 0.300861317627111 1008 NA FT VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein localized to COPII-coated vesicles; involved in vesicle formation and incorporation of specific secretory cargo; protein abundance increases in response to DNA replication stress ER to Golgi vesicle-mediated transport molecular_function integral to membrane|ER to Golgi transport vesicle
YLR058C YLR058C SHM2 hom Verified 0.537980767936445 0.295295163044731 no 1382 0.291439853975986 988 NA FT KETONE METABOLISM|AMINO ACID METABOLISM SITE OF POLARIZED GROWTH Cytosolic serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis one-carbon metabolic process glycine hydroxymethyltransferase activity plasma membrane|mating projection tip|cytoplasm
YKR039W YKR039W GAP1 hom Verified 0.537892381351874 0.295325674243448 no 1383 0.292905398939962 958 NA FT KETONE METABOLISM|AMINO ACID METABOLISM PLASMA MEMBRANE General amino acid permease; Gap1p senses the presence of amino acid substrates to regulate localization to the plasma membrane when needed; essential for invasive growth amino acid transport|gamma-aminobutyric acid transport|ammonia assimilation cycle|polyamine transport amino acid transmembrane transporter activity|polyamine transmembrane transporter activity|L-proline transmembrane transporter activity endosome|fungal-type vacuole lumen|integral to membrane|plasma membrane|ER to Golgi transport vesicle|integral to plasma membrane|multivesicular body
YOR208W YOR208W PTP2 hom Verified 0.536626135594832 0.295762943594252 no 1384 0.286598495739412 983 NA FT PROTEIN LOCALIZATION|SIGNALING|PROTEIN PHOSPHORYLATION NUCLEUS Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the nucleus inactivation of MAPK activity involved in osmosensory signaling pathway|inactivation of MAPK activity involved in cell wall biogenesis|regulation of sporulation|regulation of protein localization|protein dephosphorylation protein tyrosine phosphatase activity nucleus
YMR082C_d YMR082C YMR082C hom Dubious 0.536239798912683 0.295896415434487 no 1385 0.312865044365218 1033 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR285W YLR285W NNT1 hom Verified 0.535709604364536 0.296079632395374 no 1386 0.280536370700061 937 NA FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|GENE SILENCING S-adenosylmethionine-dependent methyltransferase; has a role in rDNA silencing and in lifespan determination chromatin silencing at rDNA|nicotinamide metabolic process S-adenosylmethionine-dependent methyltransferase activity|nicotinamide N-methyltransferase activity cytoplasm
YDR252W YDR252W BTT1 hom Verified 0.535548455014246 0.296135330371658 no 1387 0.293700934122916 983 NA FT PROTEIN LOCALIZATION NUCLEUS Beta3 subunit of the heterotrimeric nascent polypeptide-associated complex which binds ribosomes via its beta-subunits in close proximity to nascent polypeptides; interacts with Caf130p of the CCR4-NOT complex; similar to human BTF3 'de novo' cotranslational protein folding unfolded protein binding nascent polypeptide-associated complex|CCR4-NOT complex
YDR178W YDR178W SDH4 hom Verified 0.534397209759738 0.296533374521032 no 1388 0.32491787622408 1105 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain mitochondrial electron transport, succinate to ubiquinone|cellular respiration|tricarboxylic acid cycle succinate dehydrogenase (ubiquinone) activity mitochondrial respiratory chain complex II|mitochondrion
YFR008W YFR008W FAR7 hom Verified 0.53435646848248 0.296547465346723 no 1389 0.301119298265994 1044 NA FT CELL CYCLE|SIGNALING Protein involved in recovery from pheromone-induced cell cycle arrest; acts in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p; protein abundance increases in response to DNA replication stress re-entry into mitotic cell cycle after pheromone arrest molecular_function cellular_component
YBL098W YBL098W BNA4 hom Verified 0.534137288119869 0.2966232765867 no 1390 0.28553564203366 976 NA FT OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM MITOCHONDRION Kynurenine 3-mono oxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; putative therapeutic target for Huntington disease de novo NAD biosynthetic process from tryptophan kynurenine 3-monooxygenase activity mitochondrial outer membrane|mitochondrion
YDR440W YDR440W DOT1 hom Verified 0.533408218973479 0.296875514654052 no 1391 0.300525912004872 1040 NA FT CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING NUCLEUS Nucleosomal histone H3-Lys79 methylase; methylation is required for telomeric silencing, meiotic checkpoint control, and DNA damage response meiotic recombination checkpoint|postreplication repair|recombinational repair|global genome nucleotide-excision repair|nucleotide-excision repair|DNA damage checkpoint|chromatin silencing at telomere|histone H3-K79 methylation nucleosomal histone binding|histone methyltransferase activity (H3-K79 specific) nucleus
YOR298W YOR298W MUM3 hom Verified 0.533088788583855 0.296986059784464 no 1392 0.303115455726296 1026 NA FT LIPID METABOLISM|CELL WALL ORG/BIOGENESIS Protein of unknown function involved in the organization of the outer spore wall layers; has similarity to the tafazzins superfamily of acyltransferases ascospore wall assembly|phospholipid biosynthetic process transferase activity, transferring acyl groups cellular_component
YBL012C_d YBL012C YBL012C hom Dubious 0.533081940130833 0.296988430031666 no 1393 0.296566864165146 1016 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLL009C YLL009C COX17 hom Verified 0.531500288107065 0.297536070855692 no 1394 0.287639379237829 946 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS MITOCHONDRION Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs mitochondrial respiratory chain complex IV assembly|intracellular copper ion transport copper chaperone activity cytosol|mitochondrion|mitochondrial intermembrane space
YJR019C YJR019C TES1 hom Verified 0.530729506346474 0.297803117997875 no 1395 0.295439173917657 996 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM MITOCHONDRION Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids fatty acid beta-oxidation|fatty acid oxidation acyl-CoA hydrolase activity mitochondrion|peroxisome
YMR300C YMR300C ADE4 hom Verified 0.529708897183175 0.298156889128918 no 1396 0.307432327589418 1046 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway 'de novo' IMP biosynthetic process amidophosphoribosyltransferase activity cytoplasm
YGL190C YGL190C CDC55 hom Verified 0.529499723244128 0.298229418184837 no 1397 0.399995129236176 1334 NA FT CELL CYCLE|SIGNALING NUCLEUS|SITE OF POLARIZED GROWTH Non-essential regulatory subunit B of protein phosphatase 2A (PP2A); localization to the cytoplasm requires Zds1p and Zds2p and promotes mitotic entry; localization to the nucleus prevents mitotic exit; required for correct nuclear division and chromosome segregation in meiosis; maintains nucleolar sequestration of Cdc14p during early meiosis; limits formation of PP2A-Rts1p holocomplexes to ensure timely dissolution of sister chromosome cohesion negative regulation of exit from mitosis|positive regulation of G2/M transition of mitotic cell cycle|cell shape checkpoint|protein dephosphorylation protein phosphatase type 2A regulator activity nucleus|cellular bud neck|cytoplasm|cellular bud tip
YIL149C YIL149C MLP2 hom Verified 0.528826725268057 0.298462828267169 no 1398 0.280699456300706 952 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CYTOSKELETON ORGANIZATION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION|CYTOSKELETON Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved in the Tel1p pathway that controls telomere length poly(A)+ mRNA export from nucleus|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|regulation of transcription, DNA-dependent|telomere tethering at nuclear periphery|spindle pole body organization|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery ribonucleoprotein complex binding nucleoplasm|nuclear envelope|mitochondrion|ribonucleoprotein complex|integral to membrane|spindle pole body
YKL065C YKL065C YET1 hom Verified 0.528413533774755 0.298606173077755 no 1399 0.277937536867736 982 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Endoplasmic reticulum transmembrane protein; may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein biological_process molecular_function ribosome|integral to membrane|endoplasmic reticulum|endoplasmic reticulum membrane
YLR292C YLR292C SEC72 hom Verified 0.528367915283764 0.29862200100974 no 1400 0.315372572626925 1059 NA FT PROTEIN LOCALIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER posttranslational protein targeting to membrane, translocation protein transporter activity Sec62/Sec63 complex|endoplasmic reticulum membrane
YDL170W YDL170W UGA3 hom Verified 0.528353643397387 0.298626952905696 no 1401 0.293886002861532 971 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|RESPONSE TO NUTRIENT LEVELS NUCLEUS Transcriptional activator necessary for gamma-aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1, UGA2, UGA4); zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus nitrogen utilization|nitrogen catabolite activation of transcription from RNA polymerase II promoter|gamma-aminobutyric acid catabolic process sequence-specific DNA binding transcription factor recruiting transcription factor activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YFR055W_p YFR055W IRC7 hom Uncharacterized 0.527882870335204 0.298790317286374 no 1402 0.297898557082352 1004 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Beta-lyase involved in the production of thiols; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner and by copper levels in a Mac1-dependent manner sulfur compound metabolic process|L-cysteine catabolic process to pyruvate cysteine-S-conjugate beta-lyase activity cellular_component
YPL195W YPL195W APL5 hom Verified 0.527033103131775 0.299085300341621 no 1403 0.322136198309576 1071 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Delta adaptin-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function vesicle-mediated transport|Golgi to vacuole transport protein binding AP-3 adaptor complex
YCL050C YCL050C APA1 hom Verified 0.526835206379239 0.299154016000652 no 1404 0.302183531928796 1012 NA FT NUCLEOTIDE METABOLISM NUCLEUS AP4A phosphorylase; bifunctional diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase and ADP sulfurylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; catalyzes phosphorolysis of dinucleoside oligophosphates, cleaving substrates' alpha/beta-anhydride bond and introducing Pi into the beta-position of the corresponding NDP formed; protein abundance increases under DNA replication stress; APA1 has a paralog, APA2, that arose from the whole genome duplication nucleotide biosynthetic process|nucleoside catabolic process bis(5'-nucleosyl)-tetraphosphatase activity|sulfate adenylyltransferase (ADP) activity nucleus|cytoplasm
YLL001W YLL001W DNM1 hom Verified 0.525114395264128 0.299751834783433 no 1405 0.287548204514915 986 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|PEROXISOME ORGANIZATION MITOCHONDRION Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance mitochondrion inheritance|peroxisome fission|mitochondrial fission|chronological cell aging|peroxisome organization|mitochondrion organization|protein homooligomerization protein homodimerization activity|GTPase activity|identical protein binding mitochondrial outer membrane|mitochondrion|peroxisome
YMR032W YMR032W HOF1 hom Verified 0.525057765930929 0.299771517302328 no 1406 0.304444566569735 1042 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION SITE OF POLARIZED GROWTH|CYTOSKELETON Bud neck-localized, SH3 domain-containing protein required for cytokinesis; is phosphorylated by Dbf2p; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p cytokinesis after mitosis|barrier septum assembly involved in cell cycle cytokinesis|response to DNA damage stimulus|cytokinesis cytoskeletal protein binding cellular bud neck contractile ring|cellular bud neck septin ring
YCR073C YCR073C SSK22 hom Verified 0.524636548755662 0.299917937089192 no 1407 0.280634176117195 959 NA FT SIGNALING|PROTEIN PHOSPHORYLATION MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; functionally redundant with, and homologous to, Ssk2p; interacts with and is activated by Ssk1p; phosphorylates Pbs2p MAPK cascade involved in osmosensory signaling pathway|protein phosphorylation protein kinase activity|MAP kinase kinase kinase activity cellular_component
YHR141C YHR141C RPL42B hom Verified 0.524066990296581 0.300115973418525 no 1408 0.322117178107908 1074 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L42B; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus; homologous to mammalian ribosomal protein L36A, no bacterial homolog; RPL42B has a paralog, RPL42A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YPL054W YPL054W LEE1 hom Verified 0.522167998450372 0.300776682628242 no 1409 0.270882676004757 934 NA Zinc-finger protein of unknown function biological_process molecular_function cellular_component
YMR163C YMR163C INP2 hom Verified 0.520577778381066 0.301330466362794 no 1410 0.289267912926532 965 NA FT PEROXISOME ORGANIZATION Peroxisome-specific receptor important for peroxisome inheritance; co-fractionates with peroxisome membranes and co-localizes with peroxisomes in vivo; physically interacts with the myosin V motor Myo2p; INP2 is not an essential gene peroxisome inheritance protein anchor peroxisome|integral to peroxisomal membrane|cytoplasm
YCL030C YCL030C HIS4 hom Verified 0.520430344926357 0.301381832345921 no 1411 0.308385908768212 1017 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase, phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis histidine biosynthetic process phosphoribosyl-ATP diphosphatase activity|phosphoribosyl-AMP cyclohydrolase activity|histidinol dehydrogenase activity intracellular
YHR073W YHR073W OSH3 hom Verified 0.520218974256381 0.301455481003207 no 1412 0.294177932373769 1009 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOPLASMIC RETICULUM Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability karyogamy involved in conjugation with cellular fusion|endocytosis|exocytosis|positive regulation of phosphatase activity|maintenance of cell polarity|pseudohyphal growth|sterol transport|invasive growth in response to glucose limitation lipid binding|oxysterol binding|1-phosphatidylinositol binding|sterol transporter activity cortical endoplasmic reticulum|cytoplasm
YOL116W YOL116W MSN1 hom Verified 0.519189451031174 0.301814317299803 no 1413 0.305579777903499 1036 NA FT TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM NUCLEUS Transcriptional activator; involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress; localizes to the nucleus; relative distribution to the nucleus increases upon DNA replication stress positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription from RNA polymerase II promoter in response to methylglyoxal|positive regulation of transcription from RNA polymerase II promoter in response to increased salt|Unknown|positive regulation of starch catabolic process by positive regulation of transcription from RNA polymerase II promoter|positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding nucleus
YIL041W YIL041W GVP36 hom Verified 0.519074858496922 0.301854269950699 no 1414 0.317848725213014 1082 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION ENDOMEMBRANE SYSTEM|GOLGI APPARATUS BAR domain-containing protein that localizes to both early and late Golgi vesicles; required for adaptation to varying nutrient concentrations, fluid-phase endocytosis, polarization of the actin cytoskeleton, and vacuole biogenesis vacuole organization|endocytosis|establishment or maintenance of actin cytoskeleton polarity molecular_function integral to Golgi membrane|cytoplasm
YCR007C_p YCR007C YCR007C hom Uncharacterized 0.51797568972724 0.302237615465239 no 1415 0.313986884013779 1055 NA Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene biological_process molecular_function cellular_component
YLR405W YLR405W DUS4 hom Verified 0.515276899864052 0.303179769361238 no 1416 0.292955556247715 987 NA FT RNA PROCESSING|OXIDATION-REDUCTION PROCESS Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p tRNA modification tRNA dihydrouridine synthase activity cellular_component
YIL054W_p YIL054W YIL054W hom Uncharacterized 0.51419368414192 0.303558291528415 no 1417 0.307434820507342 1081 NA Protein of unknown function; expressed at both mRNA and protein levels biological_process molecular_function cellular_component
YIL018W YIL018W RPL2B hom Verified 0.513678608874726 0.303738354983531 no 1418 0.282054021222349 958 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L2B; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2B has a paralog, RPL2A, that arose from the whole genome duplication; expression is upregulated at low temperatures cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YCL029C YCL029C BIK1 hom Verified 0.513320838223082 0.303863454884151 no 1419 0.311647523800354 1090 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION NUCLEUS|SITE OF POLARIZED GROWTH|CHROMOSOME|CYTOSKELETON KINETOCHORE Microtubule-associated protein, component of the interface between microtubules and kinetochore, involved in sister chromatid separation; essential in polyploid cells but not in haploid or diploid cells; ortholog of mammalian CLIP-170 karyogamy involved in conjugation with cellular fusion|mitotic anaphase B|negative regulation of microtubule polymerization|nuclear migration involved in conjugation with cellular fusion|mitotic spindle organization in nucleus|mitotic spindle elongation microtubule binding|protein homodimerization activity spindle microtubule|microtubule plus end|spindle pole body|cell cortex|condensed nuclear chromosome kinetochore|mating projection tip|kinetochore|spindle
YKL109W YKL109W HAP4 hom Verified 0.51311716121276 0.303934683885021 no 1420 0.302356264028009 1017 NA FT TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex regulation of cellular respiration|carbon catabolite activation of transcription from RNA polymerase II promoter RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor binding transcription factor activity CCAAT-binding factor complex
YDL199C_p YDL199C YDL199C hom Uncharacterized 0.512599597749591 0.304115717322496 no 1421 0.283175807541589 966 NA Putative transporter, member of the sugar porter family transport|transmembrane transport substrate-specific transmembrane transporter activity integral to membrane|membrane
YIL029C_p YIL029C YIL029C hom Uncharacterized 0.511733697360975 0.304418699499972 no 1422 0.317454490760664 1094 NA Putative protein of unknown function; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YIL029C has paralog YPR071W biological_process molecular_function integral to membrane
YOL121C YOL121C RPS19A hom Verified 0.511207546261214 0.304602867575234 no 1423 0.310354329942207 1043 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION RIBOSOME Protein component of the small (40S) ribosomal subunit; required for assembly and maturation of pre-40 S particles; homologous to mammalian ribosomal protein S19, no bacterial homolog; mutations in human RPS19 are associated with Diamond Blackfan anemia; RPS19A has a paralog, RPS19B, that arose from the whole genome duplication cytoplasmic translation|ribosomal small subunit biogenesis|rRNA export from nucleus structural constituent of ribosome cytosolic small ribosomal subunit
YER063W YER063W THO1 hom Verified 0.511178479521761 0.304613043217639 no 1424 0.272880624460373 902 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA LOCALIZATION NUCLEUS Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation poly(A)+ mRNA export from nucleus|transcription, DNA-dependent|ribonucleoprotein complex assembly chromatin binding|double-stranded DNA binding|RNA binding nucleus
YMR075W YMR075W RCO1 hom Verified 0.510484124708052 0.304856166884532 no 1425 0.311616223020453 1080 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p regulation of DNA-dependent DNA replication initiation|negative regulation of antisense RNA transcription|transcription elongation from RNA polymerase II promoter|histone deacetylation molecular_function Rpd3S complex|histone deacetylase complex|nucleus|Rpd3L complex
YPL101W YPL101W ELP4 hom Verified 0.510321705798584 0.304913049215016 no 1426 0.330791825501313 1135 NA FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity regulation of transcription from RNA polymerase II promoter|tRNA wobble uridine modification ATPase activity|tRNA binding Elongator holoenzyme complex|cytoplasm
YLR403W YLR403W SFP1 hom Verified 0.509120133639121 0.305334010060373 no 1427 0.29418644203072 1016 NA FT TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS NUCLEUS Regulates transcription of ribosomal protein and biogenesis genes; regulates response to nutrients and stress, G2/M transitions during mitotic cell cycle and DNA-damage response, and modulates cell size; regulated by TORC1 and Mrs6p; sequence of zinc finger, ChIP localization data, and protein-binding microarray (PBM) data, and computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p at others; can form the [ISP+] prion positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter|regulation of cell size|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription factor binding transcription factor activity nucleus|cytoplasm
YGL161C YGL161C YIP5 hom Verified 0.508846055890234 0.305430067024355 no 1428 0.308231939566156 1041 NA FT GOLGI APPARATUS Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport biological_process Rab GTPase binding integral to membrane|Golgi apparatus
YEL005C YEL005C VAB2 hom Verified 0.508231251466673 0.305645588353702 no 1429 0.304486169920686 1026 NA Protein with a potential role in vacuolar function, as suggested by its ability to bind Vac8p; likely member of BLOC complex involved in endosomal cargo sorting; Vab2p-GFP-fusion localizes to cytoplasm in punctate patter biological_process molecular_function cytoplasm
YJL186W YJL186W MNN5 hom Verified 0.508228674133227 0.305646491986621 no 1430 0.286640926806652 983 NA FT CARBOHYDRATE METABOLISM GOLGI APPARATUS Alpha-1,2-mannosyltransferase, responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment protein glycosylation alpha-1,2-mannosyltransferase activity Golgi apparatus
YLR343W YLR343W GAS2 hom Verified 0.508228529542257 0.305646542681362 no 1431 0.263903082449336 887 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM PLASMA MEMBRANE 1,3-beta-glucanosyltransferase, involved with Gas4p in spore wall assembly; has similarity to Gas1p ascospore wall assembly 1,3-beta-glucanosyltransferase activity integral to membrane|cytoplasm
YOL072W YOL072W THP1 hom Verified 0.508207344054294 0.305653970521698 no 1432 0.35623957027188 1186 NA FF|FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RNA PROCESSING|RESPONSE TO DNA DAMAGE|CELL DIVISION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE Nuclear pore-associated protein; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; contains a PAM domain implicated in protein-protein binding mRNA export from nucleus|mRNA 3'-end processing|transcription-coupled nucleotide-excision repair|cellular bud site selection|nuclear retention of pre-mRNA at the site of transcription|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|transcription elongation from RNA polymerase II promoter double-stranded DNA binding|RNA binding nuclear envelope|nucleus|transcription export complex 2|nuclear pore
YJL066C YJL066C MPM1 hom Verified 0.507233868145474 0.305995366970381 no 1433 0.31776608808572 1050 NA FT MITOCHONDRION Mitochondrial intermembrane space protein of unknown function biological_process molecular_function mitochondrion|extrinsic to membrane
YBR195C YBR195C MSI1 hom Verified 0.506930377254602 0.306101835231259 no 1434 0.296115516319113 988 NA FT CHROMATIN ORGANIZATION NUCLEUS Subunit of chromatin assembly factor I (CAF-1); chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription; Msi1p localizes to both nucleus and cytoplasm and has an independent role as a negative regulator of the RAS/cAMP pathway via sequestration of Npr1p kinase DNA replication-dependent nucleosome assembly histone binding nucleus|CAF-1 complex|cytoplasm
YHR049W YHR049W FSH1 hom Verified 0.50657886240743 0.306225171348685 no 1435 0.277093050979554 963 NA FT NUCLEUS Putative serine hydrolase that localizes to both the nucleus and cytoplasm; sequence is similar to S. cerevisiae Fsh2p and Fsh3p and the human candidate tumor suppressor OVCA2 biological_process hydrolase activity nucleus|cytoplasm
YER154W YER154W OXA1 hom Verified 0.505785843981818 0.306503498608982 no 1436 0.32038655867445 1095 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial inner membrane insertase, mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane, interacts with mitochondrial ribosomes; conserved from bacteria to animals protein insertion into mitochondrial membrane from inner side|mitochondrial genome maintenance|mitochondrial proton-transporting ATP synthase complex assembly mitochondrial ribosome binding|membrane insertase activity mitochondrion|mitochondrial inner boundary membrane|integral to membrane|mitochondrial crista|mitochondrial large ribosomal subunit
YHR009C_p YHR009C TDA3 hom Uncharacterized 0.505522869222351 0.306595820044908 no 1437 0.312168762737829 1065 NA FT VESICLE-MEDIATED TRANSPORT|OXIDATION-REDUCTION PROCESS Putative oxidoreductase involved in late endosome to Golgi transport; physical and genetical interactions with Btn2p; null mutant is viable, has extended S phase, and sensitive to expression of top1-T722A allele; similar to human FOXRED1 retrograde transport, endosome to Golgi molecular_function late endosome|cytoplasm
YHL027W YHL027W RIM101 hom Verified 0.505384486960954 0.306644406248881 no 1438 0.335595767166725 1152 NA FF|FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|CELL DIVISION|ION HOMEOSTASIS NUCLEUS Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression as part of adaptation to a alkaline conditions; involved in cell wall assembly; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by alkaline-dependent proteolytic processing which results in removal of the C-terminal tail; similar to A. nidulans PacC meiosis|negative regulation of transcription from RNA polymerase II promoter|fungal-type cell wall biogenesis|cellular response to anoxia|response to pH|ascospore formation|barrier septum assembly|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|sequence-specific DNA binding nucleus
YJR050W YJR050W ISY1 hom Verified 0.505278975895217 0.306681453613654 no 1439 0.32305075516818 1078 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING NUCLEUS Member of NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of spliceosome containing U2, U5, and U6 snRNAs, interacts with Prp16p to modulate splicing fidelity; isy1 syf2 cells have defective spindles generation of catalytic spliceosome for second transesterification step|mRNA 3'-splice site recognition first spliceosomal transesterification activity|second spliceosomal transesterification activity post-spliceosomal complex|Prp19 complex|post-mRNA release spliceosomal complex|U2-type catalytic step 2 spliceosome|U2-type catalytic step 1 spliceosome
YNR028W YNR028W CPR8 hom Verified 0.504924157920217 0.306806052862515 no 1440 0.287782408714648 976 NA Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; similarity to Cpr4p suggests a potential role in the secretory pathway biological_process peptidyl-prolyl cis-trans isomerase activity fungal-type vacuole
YHL033C YHL033C RPL8A hom Verified 0.504252934784241 0.307041823221553 no 1441 0.28716214120798 976 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal 60S subunit protein L8A; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8A has a paralog, RPL8B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YLL015W YLL015W BPT1 hom Verified 0.504164649310492 0.307072839860399 no 1442 0.271256067500888 913 NA FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS ABC type transmembrane transporter of MRP/CFTR family, found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p cadmium ion transport|bilirubin transport bilirubin transmembrane transporter activity|cadmium ion transmembrane transporter activity fungal-type vacuole membrane|integral to membrane
YCL069W YCL069W VBA3 hom Verified 0.503091319221152 0.307450034818948 no 1443 0.308874332445133 1049 NA Permease of basic amino acids in the vacuolar membrane basic amino acid transport|transmembrane transport basic amino acid transmembrane transporter activity fungal-type vacuole membrane|integral to membrane
YGR192C YGR192C TDH3 hom Verified 0.502592287697565 0.307625476342223 no 1444 0.312906116847294 1034 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Glyceraldehyde-3-phosphate dehydrogenase, isozyme 3; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; TDH3 has a paralog, TDH2, that arose from the whole genome duplication gluconeogenesis|reactive oxygen species metabolic process|glycolysis|apoptotic process glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity mitochondrion|fungal-type cell wall|lipid particle|plasma membrane|cytoplasm
YGR010W YGR010W NMA2 hom Verified 0.499750733979101 0.308625302117171 no 1445 0.315820225451253 1063 NA FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM NUCLEUS Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in de novo and salvage synthesis of NAD(+); NMA2 has a paralog, NMA1, that arose from the whole genome duplication NAD biosynthetic process nicotinamide-nucleotide adenylyltransferase activity nucleus
YEL016C YEL016C NPP2 hom Verified 0.49925669021219 0.308799280941094 no 1446 0.314242263212245 1060 NA FT NUCLEOTIDE METABOLISM Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp1p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; NPP2 has a paralog, NPP1, that arose from the whole genome duplication nucleoside triphosphate metabolic process nucleotide diphosphatase activity|nucleoside-triphosphate diphosphatase activity|nucleoside-triphosphatase activity|phosphodiesterase I activity cellular_component
YHL045W_d YHL045W YHL045W hom Dubious 0.499221596042962 0.308811641078927 no 1447 0.303101631231498 1047 NA Putative protein of unknown function; not an essential gene Unknown Unknown Unknown
YBL029W_p YBL029W YBL029W hom Uncharacterized 0.49908027865198 0.30886141514056 no 1448 0.320260513474334 1081 NA FT NUCLEUS Non-essential protein of unknown function biological_process molecular_function nucleus|cytoplasm
YMR071C YMR071C TVP18 hom Verified 0.498678679689037 0.309002883358045 no 1449 0.332709082890258 1137 NA FF|FT VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments vesicle-mediated transport molecular_function integral to membrane|integral to Golgi membrane|clathrin-coated vesicle
YLL020C_d YLL020C YLL020C hom Dubious 0.498556908802312 0.309045784262793 no 1450 0.287473374034189 961 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KNS1 Unknown Unknown Unknown
YLR006C YLR006C SSK1 hom Verified 0.497888801422257 0.309281210431432 no 1451 0.289252872950321 983 NA FT SIGNALING|PROTEIN PHOSPHORYLATION Cytoplasmic response regulator; part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism; required for mitophagy; dephosphorylated form is degraded by the ubiquitin-proteasome system; potential Cdc28p substrate activation of MAPKKK activity involved in osmosensory signaling pathway|positive regulation of protein autophosphorylation|osmosensory signaling pathway via two-component system protein kinase activator activity|two-component response regulator activity|protein homodimerization activity|mitogen-activated protein kinase kinase kinase binding cytoplasm
YJR021C YJR021C REC107 hom Verified 0.497350639656653 0.309470903617942 no 1452 0.298249980565669 1043 NA FT CELL CYCLE NUCLEUS|CHROMOSOME Protein involved in early stages of meiotic recombination; involved in coordination between the initiation of recombination and the first division of meiosis; part of a complex (Rec107p-Mei4p-Rec114p) required for ds break formation reciprocal meiotic recombination molecular_function condensed nuclear chromosome
YMR165C YMR165C PAH1 hom Verified 0.496951142831194 0.309611752530869 no 1453 0.309355722140292 1056 NA FT LIPID METABOLISM|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Mg2+-dependent phosphatidate (PA) phosphatase; dephosphorylates PA to yield diacylglycerol; responsible for de novo lipid synthesis and formation of lipid droplets; phosphorylation by Pho80p-Pho85p decreases catalytic activity and alters Pah1p localization and abundance; phosphorylation by protein kinase A decreases catalytic efficiency; dephosphorylation by Nem1p-Spo7p anchors Pah1p to the membrane increasing substrate catalysis; homologous to mammalian lipins 1 and 2 plasmid maintenance|vacuole fusion, non-autophagic|lipid particle organization|aerobic respiration|phospholipid biosynthetic process phosphatidate phosphatase activity cytosol|nuclear membrane|vacuole|cytoplasm|extrinsic to membrane
YOR073W YOR073W SGO1 hom Verified 0.496686620364164 0.30970502949285 no 1454 0.319872009818564 1096 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME|CYTOSKELETON KINETOCHORE Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability positive regulation of maintenance of meiotic sister chromatid cohesion|meiotic sister chromatid segregation|meiotic sister chromatid separation|sister chromatid biorientation|maintenance of meiotic sister chromatid cohesion|mitotic cell cycle spindle assembly checkpoint|mitotic sister chromatid segregation molecular_function condensed nuclear chromosome kinetochore|nucleus|spindle pole body|condensed nuclear chromosome, centromeric region
YML084W_d YML084W YML084W hom Dubious 0.495643545947309 0.31007296193458 no 1455 0.283957507774795 994 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR318W YDR318W MCM21 hom Verified 0.494767064836919 0.310382277637721 no 1456 0.329829544342789 1128 NA FT CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME KINETOCHORE Component of the kinetochore sub-complex COMA; COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) bridges kinetochore subunits in contact with centromeric DNA with subunits bound to microtubules during kinetochore assembly; involved in minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-O and fission yeast mal2 chromosome segregation|establishment of mitotic sister chromatid cohesion molecular_function COMA complex|condensed nuclear chromosome kinetochore
YFL050C YFL050C ALR2 hom Verified 0.494445954065203 0.310495633241184 no 1457 0.322337804742421 1087 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Probable Mg(2+) transporter; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; plays a role in regulating Ty1 transposition magnesium ion transport|cation transport|transmembrane transport inorganic cation transmembrane transporter activity integral to membrane|plasma membrane
YOR079C YOR079C ATX2 hom Verified 0.49413469246163 0.310605529160468 no 1458 0.279262435033962 961 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Golgi membrane protein involved in manganese homeostasis; overproduction suppresses the sod1 (copper, zinc superoxide dismutase) null mutation cellular manganese ion homeostasis manganese ion transmembrane transporter activity integral to membrane|Golgi membrane
YDR199W_d YDR199W YDR199W hom Dubious 0.49230083021874 0.311253346658453 no 1459 0.336140201702321 1154 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity Unknown Unknown Unknown
YGL023C YGL023C PIB2 hom Verified 0.490507514305142 0.311887406911156 no 1460 0.326965910217008 1099 NA FT VESICLE-MEDIATED TRANSPORT MITOCHONDRION Protein of unknown function; contains FYVE domain; similar to Fab1 and Vps27 biological_process molecular_function mitochondrion
YCL008C YCL008C STP22 hom Verified 0.490171988678236 0.312006100259796 no 1461 0.330814167246852 1114 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT PLASMA MEMBRANE Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype protein targeting to membrane|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|late endosome to vacuole transport|protein targeting to vacuole ubiquitin binding endosome|ESCRT I complex|internal side of plasma membrane
YDR084C YDR084C TVP23 hom Verified 0.490169946759547 0.312006822655356 no 1462 0.278830038631524 962 NA FT VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern vesicle-mediated transport molecular_function integral to membrane|integral to Golgi membrane|cytoplasm
YHR087W YHR087W RTC3 hom Verified 0.489606458879651 0.312206202556494 no 1463 0.332925582527054 1145 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1); null mutation suppresses cdc13-1 temperature sensitivity; protein abundance increases in response to DNA replication stress RNA metabolic process molecular_function nucleus|cytoplasm
YLR354C YLR354C TAL1 hom Verified 0.489423876750838 0.312270817713295 no 1464 0.340849161002845 1159 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS NUCLEUS Transaldolase, enzyme in the non-oxidative pentose phosphate pathway; converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate pentose-phosphate shunt sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity nucleus|cytoplasm
YNL336W YNL336W COS1 hom Verified 0.488444758838691 0.312617422479858 no 1465 0.312016307673735 1045 NA Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins biological_process molecular_function integral to membrane|fungal-type vacuole
YDL041W_d YDL041W YDL041W hom Dubious 0.487960713560261 0.312788834298329 no 1466 0.340897028372138 1171 NA FF Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIR2/YDL042C Unknown Unknown Unknown
YGR058W YGR058W PEF1 hom Verified 0.487700140317843 0.312881126180255 no 1467 0.302097974131889 1054 NA FT CELL CYCLE|CELL DIVISION NUCLEUS|SITE OF POLARIZED GROWTH Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly bipolar cellular bud site selection|regulation of COPII vesicle coating|axial cellular bud site selection zinc ion binding|calcium ion binding cytosol|site of polarized growth|nucleus|cellular bud neck|cytoplasm
YNL338W_d YNL338W YNL338W hom Dubious 0.487278602838169 0.313030454476203 no 1468 0.30003024061876 1032 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps TEL14L-XC, which is Telomeric X element Core sequence on the left arm of Chromosome XIV Unknown Unknown Unknown
YOL002C YOL002C IZH2 hom Verified 0.486172438778014 0.313422455350115 no 1469 0.312388612243017 1078 NA FT KETONE METABOLISM|LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc response to zinc ion|cellular zinc ion homeostasis|response to toxin|cellular lipid metabolic process protein binding|metal ion binding integral to membrane|plasma membrane|membrane
YOL068C YOL068C HST1 hom Verified 0.485502513831611 0.313659964966248 no 1470 0.321260566765045 1107 NA FT CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME NAD(+)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing and mitotic repression; non-essential subunit of the Set3C deacetylase complex; involved in telomere maintenance chromatin silencing|negative regulation of mitotic recombination|histone deacetylation NAD-independent histone deacetylase activity|NAD-dependent histone deacetylase activity Set3 complex
YML019W YML019W OST6 hom Verified 0.484645131191605 0.313964046978886 no 1471 0.327696533340263 1119 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p protein N-linked glycosylation via asparagine|protein complex assembly dolichyl-diphosphooligosaccharide-protein glycotransferase activity oligosaccharyltransferase complex|integral to membrane
YDR462W YDR462W MRPL28 hom Verified 0.482794756869988 0.314620737000934 no 1472 0.316154988203789 1076 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YIL095W YIL095W PRK1 hom Verified 0.481866585147944 0.314950362369274 no 1473 0.30673764893247 1036 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION SITE OF POLARIZED GROWTH|CYTOSKELETON Protein serine/threonine kinase; regulates the organization and function of the actin cytoskeleton and reduces endocytic ability of cell through the phosphorylation of the Pan1p-Sla1p-End3p protein complex; PRK1 has a paralog, ARK1, that arose from the whole genome duplication regulation of endocytosis|actin filament organization|protein phosphorylation|actin cortical patch assembly|cytokinesis protein serine/threonine kinase activity|protein kinase activity mating projection tip|actin cortical patch
YBL103C YBL103C RTG3 hom Verified 0.481781251208704 0.314980674760454 no 1474 0.309018915295736 1054 NA FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|SIGNALING NUCLEUS Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways mitochondrion degradation|cellular response to oleic acid|mitochondria-nucleus signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription factor import into nucleus RNA polymerase II transcription factor binding|sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity nucleus|cytoplasm
YHR210C_p YHR210C YHR210C hom Uncharacterized 0.481572345643644 0.31505488762445 no 1475 0.316509517428189 1069 NA FT CARBOHYDRATE METABOLISM Putative aldose 1-epimerase superfamily protein; non-essential gene; highly expressed under anaeorbic conditions biological_process molecular_function cellular_component
YBR271W YBR271W EFM2 hom Verified 0.480838545560148 0.315315626318821 no 1476 0.350236362283739 1150 NA S-adenosylmethionine-dependent methyltransferase; methylates translation elongation factors EF2 (Eft1p and Eft2p) and EF3A (Yef3p); belongs to the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; predicted to be involved in ribosome biogenesis peptidyl-lysine methylation S-adenosylmethionine-dependent methyltransferase activity|protein-lysine N-methyltransferase activity cytoplasm
YBR281C YBR281C DUG2 hom Verified 0.480582159825725 0.315406748688836 no 1477 0.306246466347412 1070 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|PROTEOLYSIS NUCLEUS Component of glutamine amidotransferase (GATase II); forms a complex with Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p) glutathione catabolic process peptidase activity|gamma-glutamyltransferase activity|omega peptidase activity nucleus|cytoplasm
YOR023C YOR023C AHC1 hom Verified 0.480364598002924 0.315484081411336 no 1478 0.298573904270124 1011 NA FT CHROMATIN ORGANIZATION NUCLEUS HISTONE ACETYLTRANSFERASE Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex histone acetylation histone acetyltransferase activity Ada2/Gcn5/Ada3 transcription activator complex
YGL151W YGL151W NUT1 hom Verified 0.479404684970075 0.315825380604619 no 1479 0.314167099127099 1066 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS|MITOCHONDRION Component of the RNA polymerase II mediator complex, which is required for transcriptional activation and also has a role in basal transcription regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter molecular_function mitochondrion|mediator complex|nucleus
YEL037C YEL037C RAD23 hom Verified 0.478471742138942 0.316157241024137 no 1480 0.303983385664464 1014 NA FT RESPONSE TO DNA DAMAGE|PROTEOLYSIS NUCLEUS|MITOCHONDRION Protein with ubiquitin-like N terminus, subunit of Nuclear Excision Repair Factor 2 (NEF2) with Rad4p that binds damaged DNA; enhances protein deglycosylation activity of Png1p; also involved, with Rad4p, in ubiquitylated protein turnover proteasomal ubiquitin-dependent protein catabolic process|nucleotide-excision repair, DNA damage recognition|ER-associated protein catabolic process|protein deglycosylation damaged DNA binding|ubiquitin binding|peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity|protein binding, bridging proteasome complex|mitochondrion|nucleotide-excision repair factor 2 complex
YHR134W YHR134W WSS1 hom Verified 0.476659528531642 0.31680229323308 no 1481 0.260847656036814 914 NA FT RESPONSE TO DNA DAMAGE ENDOMEMBRANE SYSTEM|NUCLEUS Sumoylated protein that localizes to a single spot on the nuclear periphery of mother cells but not daughters; interacts genetically with SMT3; UV-sensitive mutant phenotype and genetic interactions suggest a role in the DNA damage response protein sumoylation|response to UV-B|response to UV-C|response to DNA damage stimulus molecular_function nuclear envelope
YCR094W YCR094W CDC50 hom Verified 0.476439066192631 0.316880804232187 no 1482 0.354478443184913 1188 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION GOLGI APPARATUS Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Lem3p; CDC50 has a paralog, YNR048W, that arose from the whole genome duplication intracellular protein transport|phospholipid translocation|endocytosis|actin cortical patch localization phospholipid-translocating ATPase activity trans-Golgi network|late endosome membrane
YER039C YER039C HVG1 hom Verified 0.475939843254681 0.317058617870452 no 1483 0.317556073895598 1100 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Protein of unknown function, has homology to Vrg4p biological_process molecular_function integral to membrane
YOL067C YOL067C RTG1 hom Verified 0.475404407691313 0.317249376712818 no 1484 0.338939963302265 1126 NA FT TRANSCRIPTION FROM RNA POL II|SIGNALING NUCLEUS Transcription factor (bHLH) involved in interorganelle communication between mitochondria, peroxisomes, and nucleus cellular response to oleic acid|positive regulation of transcription from RNA polymerase II promoter|mitochondria-nucleus signaling pathway sequence-specific DNA binding RNA polymerase II transcription factor activity nucleus|cytoplasm
YHR120W YHR120W MSH1 hom Verified 0.475095952367145 0.31735929168794 no 1485 0.297837903660296 1045 NA FT RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION MITOCHONDRION DNA-binding protein of the mitochondria involved in repair of mitochondrial DNA, has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during meiosis DNA repair|mismatch repair|mitochondrial DNA repair|mitochondrion organization|reciprocal meiotic recombination|mitochondrial genome maintenance guanine/thymine mispair binding|dinucleotide insertion or deletion binding|DNA-dependent ATPase activity mitochondrion
YLR348C YLR348C DIC1 hom Verified 0.473797494125102 0.317822160855057 no 1486 0.310431771224069 1012 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix dicarboxylic acid transport dicarboxylic acid transmembrane transporter activity mitochondrial envelope|mitochondrion|integral to membrane
YOR363C YOR363C PIP2 hom Verified 0.473443182930822 0.31794851377671 no 1487 0.307914079670597 1034 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS NUCLEUS Autoregulatory oleate-specific transcriptional activator of peroxisome proliferation, contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes; PIP2 has a paralog, OAF1, that arose from the whole genome duplication cellular response to oleic acid|positive regulation of fatty acid beta-oxidation|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription integral to membrane|nucleus
YOR121C_d YOR121C YOR121C hom Dubious 0.472374500500176 0.318329751009284 no 1488 0.31640291828459 1046 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GCY1/YOR120W Unknown Unknown Unknown
YBR111W-A YBR111W-A SUS1 hom Verified 0.471839525559979 0.31852066802228 no 1489 0.383620911250768 1262 NA FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE|HISTONE ACETYLTRANSFERASE Component of both the SAGA histone acetylase and TREX-2 complexes; interacts with RNA polymerase II; involved in mRNA export coupled transcription activation and elongation; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP poly(A)+ mRNA export from nucleus|regulation of protein localization|nuclear retention of pre-mRNA at the site of transcription|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|histone deubiquitination|histone H3-K4 methylation|transcription elongation from RNA polymerase II promoter|histone H3-K79 methylation|positive regulation of transcription from RNA polymerase II promoter enzyme activator activity DUBm complex|nucleoplasm|transcription export complex 2|SAGA complex|nuclear pore
YEL062W YEL062W NPR2 hom Verified 0.471087282229427 0.318789203335943 no 1490 0.333696784916718 1097 NA FT SIGNALING|RESPONSE TO NUTRIENT LEVELS Subunit of SEA (Seh1-associated), Npr2/3, and Iml1p complexes; Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation; SEA complex is a coatomer-related complex that associates dynamically with the vacuole; Iml1p complex (Iml1p-Npr2p-Npr3p) is required for non-nitrogen-starvation (NNS)-induced autophagy; Iml1p interacts primarily with phosphorylated Npr2p; homolog of human NPRL2; target of Grr1p; required for growth on urea and proline proline transport|urea transport|regulation of TOR signaling cascade|cellular response to amino acid starvation|response to drug|cellular response to nitrogen starvation molecular_function Seh1-associated complex|extrinsic to fungal-type vacuolar membrane
YKL050C YKL050C YKL050C hom Verified 0.470785063882218 0.31889711584359 no 1491 0.272016579912329 925 NA Protein of unknown function; the YKL050W protein is a target of the SCFCdc4 ubiquitin ligase complex and YKL050W transcription is regulated by Azf1p biological_process molecular_function cellular_component
YGL254W YGL254W FZF1 hom Verified 0.470630891758025 0.318952171694092 no 1492 0.327896793645354 1086 NA FT TRANSCRIPTION FROM RNA POL II|ION HOMEOSTASIS|ION HOMEOSTASIS NUCLEUS Transcription factor involved in sulfite metabolism; sole identified regulatory target is SSU1; overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1, contains five zinc fingers; protein abundance increases in response to DNA replication stress positive regulation of sulfite transport by positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YJL047C-A_p YJL047C-A YJL047C-A hom Uncharacterized 0.470247542151104 0.319089085601912 no 1493 0.314704049537971 1034 NA Putative protein of unknown function biological_process molecular_function cellular_component
YJL145W YJL145W SFH5 hom Verified 0.469983051050081 0.319183563400818 no 1494 0.297242775643159 1019 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Non-classical phosphatidylinositol transfer protein (PITP); exhibits PI- but not PC-transfer activity; localizes to the peripheral endoplasmic reticulum, cytosol and microsomes; similar to Sec14p; partially relocalizes to the plasma membrane upon DNA replication stress Golgi to plasma membrane protein transport|phosphatidylinositol metabolic process|Unknown|regulation of exocytosis|phospholipid transport phosphatidylinositol transporter activity|phosphatidylcholine transporter activity cell periphery|cytosol|plasma membrane|cortical endoplasmic reticulum
YDR234W YDR234W LYS4 hom Verified 0.469320456897145 0.319420297539305 no 1495 0.331524406127516 1140 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway lysine biosynthetic process via aminoadipic acid homoaconitate hydratase activity mitochondrion
YDR007W YDR007W TRP1 hom Verified 0.469096641840141 0.319500279667025 no 1496 0.423345011913603 1399 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA) tryptophan biosynthetic process phosphoribosylanthranilate isomerase activity cytoplasm
YNL042W YNL042W BOP3 hom Verified 0.468156148562191 0.319836464326341 no 1497 0.295683502472399 1003 NA FT NUCLEUS Protein of unknown function, potential Cdc28p substrate; overproduction confers resistance to methylmercury cellular response to methylmercury molecular_function nucleus|cytoplasm
YDL085W YDL085W NDE2 hom Verified 0.467016376955937 0.320244080566474 no 1498 0.302685149533842 1011 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain glucose catabolic process to ethanol|NADH oxidation NADH dehydrogenase activity mitochondrion
YMR030W YMR030W RSF1 hom Verified 0.467014208336679 0.32024485633624 no 1499 0.301073014413045 1025 NA FT TRANSCRIPTION FROM RNA POL II|SIGNALING|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS|MITOCHONDRION Protein required for respiratory growth; localized to both the nucleus and mitochondrion; may interact with transcription factors to mediate the transition to respiratory growth and activate transcription of nuclear and mitochondrial genes transcription from mitochondrial promoter|calcium-mediated signaling|transcription from RNA polymerase II promoter|aerobic respiration molecular_function mitochondrion|nucleus
YLR237W YLR237W THI7 hom Verified 0.466381768541809 0.32047112950431 no 1500 0.337888654648951 1129 NA FT PLASMA MEMBRANE Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia thiamine transport thiamine transmembrane transporter activity integral to membrane|plasma membrane
YKR009C YKR009C FOX2 hom Verified 0.464147524284582 0.321271027343218 no 1501 0.28878398267798 986 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities fatty acid beta-oxidation enoyl-CoA hydratase activity|3-hydroxyacyl-CoA dehydrogenase activity peroxisome
YPL162C_p YPL162C YPL162C hom Uncharacterized 0.463657567535279 0.321446551344566 no 1502 0.322190543521152 1090 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of vacuole with cell cycle-correlated morphology biological_process molecular_function fungal-type vacuole membrane|integral to membrane
YHR142W YHR142W CHS7 hom Verified 0.463103582509435 0.321645061117992 no 1503 0.479828529527481 1593 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein of unknown function; may be involved in chitin biosynthesis by regulation of Chs3p export from the ER; relocalizes from bud neck to ER upon DNA replication stress protein folding|ER to Golgi vesicle-mediated transport|fungal-type cell wall chitin biosynthetic process unfolded protein binding integral to membrane|endoplasmic reticulum membrane
YHR012W YHR012W VPS29 hom Verified 0.46280903739701 0.321750626380746 no 1504 0.336869965287799 1138 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval retrograde transport, endosome to Golgi protein transporter activity endosome|retromer complex, inner shell|retromer complex
YDL047W YDL047W SIT4 hom Verified 0.461760689607968 0.322126471992818 no 1505 0.32622013183485 1116 NA FT CELL CYCLE|RNA PROCESSING|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CYTOSKELETON ORGANIZATION|RESPONSE TO OXIDATIVE STRESS NUCLEUS Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization intracellular protein kinase cascade|replicative cell aging|G1/S transition of mitotic cell cycle|actin cytoskeleton organization|DNA repair|cellular response to oxidative stress|fungal-type cell wall organization|TOR signaling cascade|dephosphorylation|tRNA wobble uridine modification protein serine/threonine phosphatase activity nucleus|cytoplasm
YGL033W YGL033W HOP2 hom Verified 0.461600845932953 0.322183793919021 no 1506 0.349157393424094 1182 NA FF|FT CELL CYCLE NUCLEUS|CHROMOSOME Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair synapsis|reciprocal meiotic recombination protein binding|double-stranded DNA binding condensed nuclear chromosome
YHL012W_p YHL012W YHL012W hom Uncharacterized 0.46076552906927 0.322483417695135 no 1507 0.293921106137737 1014 NA Putative UTP glucose-1-phosphate uridylyltransferase; YHL012W has a paralog, UGP1, that arose from the whole genome duplication biological_process molecular_function cellular_component
YBL017C YBL017C PEP1 hom Verified 0.46042583109295 0.322605298577126 no 1508 0.295493046581185 983 NA FT PROTEIN LOCALIZATION|VACUOLAR TRANSPORT GOLGI APPARATUS Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments vacuolar transport|protein targeting to vacuole signal sequence binding integral to membrane|Golgi apparatus
YIR002C YIR002C MPH1 hom Verified 0.460324457120308 0.322641674431311 no 1509 0.317843485555714 1078 NA FT RESPONSE TO DNA DAMAGE NUCLEUS 3'-5' DNA helicase involved in error-free bypass of DNA lesions; binds to flap DNA in an error-free bypass pathway and stimulates the activity of Rad27p and Dna2p; also involved in interstrand cross-link repair mutations confer a mutator phenotype; similarity to FANCM, a human Fanconi anemia complementation group protein that along with the MHF complex is involved in stabilizing and remodeling blocked replication forks; member of the SF2 DExD/H superfamily of helicases negative regulation of strand invasion|recombinational repair|DNA replication, Okazaki fragment processing flap-structured DNA binding|3'-5' DNA helicase activity nucleus
YER044C YER044C ERG28 hom Verified 0.457608815653518 0.323616754422367 no 1510 0.332356213681648 1132 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Endoplasmic reticulum membrane protein, may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER, also interacts with Erg6p ergosterol biosynthetic process protein binding, bridging endoplasmic reticulum membrane
YCR020W-B YCR020W-B HTL1 hom Verified 0.457088541218095 0.323803703073043 no 1511 0.342143963562845 1163 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS RSC COMPLEX Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance regulation of cell cycle|nucleosome disassembly|response to DNA damage stimulus|chromatin remodeling|transcription elongation from RNA polymerase II promoter chromatin binding RSC complex
YIL146C YIL146C ATG32 hom Verified 0.456055616300907 0.324174992610372 no 1512 0.298902194934813 1013 NA FT CELL WALL ORG/BIOGENESIS MITOCHONDRION Mitochondrial outer membrane protein required to initiate mitophagy; recruits the autophagy adaptor protein Atg11p and the ubiquitin-like protein Atg8p to the mitochondrial surface to initiate mitophagy, the selective vacuolar degradation of mitochondria in response to starvation; can promote pexophagy when placed ectopically in the peroxisomal membrane fungal-type cell wall organization|mitochondrion degradation molecular_function integral to mitochondrial outer membrane
YGR189C YGR189C CRH1 hom Verified 0.455919019765716 0.324224105957391 no 1513 0.310982582696909 1058 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress fungal-type cell wall organization|cell wall chitin metabolic process transferase activity, transferring glycosyl groups incipient cellular bud site|fungal-type cell wall
YHR021C YHR021C RPS27B hom Verified 0.455690022775741 0.324306448792173 no 1514 0.336042893257293 1116 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27B has a paralog, RPS27A, that arose from the whole genome duplication cytoplasmic translation|ribosomal small subunit assembly|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit
YDL182W YDL182W LYS20 hom Verified 0.455614978911363 0.324333434966336 no 1515 0.306598760985743 1022 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS|MITOCHONDRION Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS20 has a paralog, LYS21, that arose from the whole genome duplication lysine biosynthetic process via aminoadipic acid homocitrate synthase activity mitochondrion|nucleus
YMR092C YMR092C AIP1 hom Verified 0.455148219824429 0.324501304737949 no 1516 0.318604611062342 1058 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON Actin cortical patch component; interacts with the actin depolymerizing factor cofilin; required to restrict cofilin localization to cortical patches; contains WD repeats; protein increases in abundance and relocalizes from cytoplasm to plasma membrane upon DNA replication stress actin filament depolymerization|response to osmotic stress actin binding nucleus|mating projection tip|cytoplasm|actin cortical patch
YGL013C YGL013C PDR1 hom Verified 0.455090561856271 0.324522043885287 no 1517 0.423452342889637 1395 NA FF|FT TRANSCRIPTION FROM RNA POL II NUCLEUS RSC COMPLEX Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication Unknown|positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YCR102W-A_d YCR102W-A YCR102W-A hom Dubious 0.454099981618232 0.32487843325713 no 1518 0.295232202715211 997 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGL198W YGL198W YIP4 hom Verified 0.452945604518481 0.325293955493781 no 1519 0.335819741773589 1124 NA FT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport biological_process Rab GTPase binding integral to membrane|Golgi apparatus
YKR104W YKR104W YKR104W hom Verified 0.452778862464947 0.325353992875287 no 1520 0.319738104205297 1098 NA FT NUCLEOTIDE METABOLISM Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; contains a stop codon in S288C; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds transport ATPase activity, coupled to transmembrane movement of substances integral to membrane|membrane
YBL011W YBL011W SCT1 hom Verified 0.452325192871711 0.32551736473591 no 1521 0.319848598059968 1092 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase of the glycerolipid biosynthesis pathway, prefers 16-carbon fatty acids, similar to Gpt2p, gene is constitutively transcribed phospholipid biosynthetic process glycerol-3-phosphate O-acyltransferase activity|glycerone-phosphate O-acyltransferase activity integral to membrane|endoplasmic reticulum
YIL090W YIL090W ICE2 hom Verified 0.452163366408675 0.325575648500081 no 1522 0.334378412657314 1156 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Integral ER membrane protein with type-III transmembrane domains; required for maintenance of ER zinc homeostasis; necessary for efficient targeting of Trm1p tRNA methyltransferase to inner nuclear membrane; mutations cause defects in cortical ER morphology in both the mother and daughter cells endoplasmic reticulum inheritance molecular_function integral to endoplasmic reticulum membrane|integral to membrane|endoplasmic reticulum
YPR167C YPR167C MET16 hom Verified 0.452097664397809 0.325599313093842 no 1523 0.323680252079312 1099 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS 3'-phosphoadenylsulfate reductase, reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)|sulfur amino acid metabolic process phosphoadenylyl-sulfate reductase (thioredoxin) activity cytoplasm
YGR015C_p YGR015C YGR015C hom Uncharacterized 0.449386534137281 0.326576421789105 no 1524 0.340351102503138 1131 NA FT MITOCHONDRION Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion biological_process molecular_function mitochondrion
YKL170W YKL170W MRPL38 hom Verified 0.448281521232585 0.326975017531492 no 1525 0.337728163882498 1154 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YLL026W YLL026W HSP104 hom Verified 0.446791147646491 0.327512931750859 no 1526 0.33089778381088 1123 NA FT PROTEIN LOCALIZATION|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS NUCLEUS Disaggregase; heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress trehalose metabolism in response to heat stress|protein folding in endoplasmic reticulum|protein unfolding|chaperone cofactor-dependent protein refolding|inheritance of oxidatively modified proteins involved in replicative cell aging|cellular heat acclimation ADP binding|unfolded protein binding|ATPase activity, coupled|chaperone binding|ATP binding TRC complex|nucleus|cytoplasm
YJR095W YJR095W SFC1 hom Verified 0.445972051658658 0.327808717229248 no 1527 0.318084984380421 1079 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization succinate transport|fumarate transport succinate:fumarate antiporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YBR041W YBR041W FAT1 hom Verified 0.445482578738249 0.32798552342237 no 1528 0.371786342021115 1206 NA FT KETONE METABOLISM|LIPID METABOLISM ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Very long chain fatty acyl-CoA synthetase and long chain fatty acid transporter; activates imported fatty acids with a preference for very long lengths (C20-C26); has a separate function in the transport of long chain fatty acids very long-chain fatty acid metabolic process|long-chain fatty acid transport very long-chain fatty acid-CoA ligase activity|long-chain fatty acid transporter activity intrinsic to internal side of plasma membrane|integral to membrane|endoplasmic reticulum|lipid particle|peroxisome
YOR071C YOR071C NRT1 hom Verified 0.444961418999434 0.328173817830525 no 1529 0.317610074645383 1068 NA FT PLASMA MEMBRANE High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity thiamine transport|nicotinamide riboside transport nicotinamide riboside transporter activity integral to membrane|plasma membrane
YAR020C YAR020C PAU7 hom Verified 0.444915580498604 0.328190381317616 no 1530 0.332021496257911 1098 NA Member of the seripauperin multigene family, active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme biological_process molecular_function cellular_component
YDR149C_d YDR149C YDR149C hom Dubious 0.444677028209797 0.328276586311984 no 1531 0.326991330375678 1124 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene NUM1; null mutation blocks anaerobic growth Unknown Unknown Unknown
YER149C YER149C PEA2 hom Verified 0.443574104163482 0.328675265806705 no 1532 0.303291716632422 1013 NA FT CELL CYCLE|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Coiled-coil polarisome protein required for polarized morphogenesis, cell fusion, and low affinity Ca2+ influx; forms polarisome complex with Bni1p, Bud6p, and Spa2p; localizes to sites of polarized growth bipolar cellular bud site selection|regulation of initiation of mating projection growth|regulation of termination of mating projection growth|actin filament organization|pseudohyphal growth|establishment of cell polarity|filamentous growth|Rho protein signal transduction cytoskeletal regulatory protein binding polarisome|actin cap|mating projection tip
YMR004W YMR004W MVP1 hom Verified 0.443244618730434 0.328794404425136 no 1533 0.344720129022334 1174 NA FT PROTEIN LOCALIZATION|VACUOLAR TRANSPORT NUCLEUS Protein required for sorting proteins to the vacuole; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions; protein abundance increases in response to DNA replication stress protein targeting to vacuole phosphatidylinositol-3-phosphate binding nucleus|cytoplasm
YPR195C_d YPR195C YPR195C hom Dubious 0.442990374575456 0.328886348448677 no 1534 0.312633571997492 1048 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR368W YDR368W YPR1 hom Verified 0.442894079488858 0.328921174992652 no 1535 0.327877379888237 1112 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS NUCLEUS NADPH-dependent aldo-keto reductase; reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases; protein abundance increases in response to DNA replication stress; YPR1 has a paralog, GCY1, that arose from the whole genome duplication cellular response to oxidative stress|D-xylose catabolic process|arabinose catabolic process glucose 1-dehydrogenase (NADP+) activity|alditol:NADP+ 1-oxidoreductase activity|carbonyl reductase (NADPH) activity nucleus|cytoplasm
YDR264C YDR264C AKR1 hom Verified 0.441963853213191 0.329257681540097 no 1536 0.459267893513035 1528 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats; AKR1 has a paralog, AKR2, that arose from the whole genome duplication protein targeting to membrane|regulation of endocytosis|regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion|protein palmitoylation palmitoyltransferase activity integral to membrane|Golgi apparatus|membrane
YIL108W YIL108W YIL108W hom Verified 0.441571724744254 0.32939957430349 no 1537 0.299068463010351 987 NA FT PROTEOLYSIS Putative metalloendopeptidase; forms cytoplasmic foci upon DNA replication stress biological_process molecular_function cytoplasm
YDR092W YDR092W UBC13 hom Verified 0.440737303493621 0.329701593675876 no 1538 0.327423784542578 1099 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE NUCLEUS Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus postreplication repair|protein monoubiquitination|protein polyubiquitination|free ubiquitin chain polymerization ubiquitin-protein ligase activity ubiquitin conjugating enzyme complex|nucleus|cytoplasm
YNL277W-A_p YNL277W-A YNL277W-A hom Uncharacterized 0.439534846442042 0.330137019222664 no 1539 0.305516666998756 1055 NA Putative protein of unknown function biological_process molecular_function cellular_component
YDR386W YDR386W MUS81 hom Verified 0.439128376280147 0.330284259508925 no 1540 0.379951151312813 1273 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p DNA repair|DNA topological change|reciprocal meiotic recombination|resolution of meiotic recombination intermediates|response to DNA damage stimulus crossover junction endodeoxyribonuclease activity|endonuclease activity Holliday junction resolvase complex|nucleus
YBL013W YBL013W FMT1 hom Verified 0.435705466375235 0.331525219577866 no 1541 0.364281434420601 1233 NA FT KETONE METABOLISM|RNA PROCESSING|AMINO ACID METABOLISM|TRANSLATION MITOCHONDRION Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate translational initiation|methionyl-tRNA aminoacylation methionyl-tRNA formyltransferase activity mitochondrion
YKR021W YKR021W ALY1 hom Verified 0.434138811533106 0.33209382156945 no 1542 0.330285672561086 1089 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION Alpha arrestin that controls nutrient-mediated intracellular sorting of permease Gap1p; interacts with AP-1 subunit Apl4p; may regulate endocytosis of plasma membrane proteins by recruiting ubiquitin ligase Rsp5p to plasma membrane targets; ALY1 has a paralog, ALY2, that arose from the whole genome duplication Unknown|regulation of intracellular transport|ubiquitin-dependent endocytosis ubiquitin protein ligase binding late endosome|cytoplasm|early endosome
YGR085C YGR085C RPL11B hom Verified 0.433344931751348 0.332382100200477 no 1543 0.359412640448843 1222 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal 60S subunit protein L11B; expressed at half the level of Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of 60S proteins and RNA; homologous to mammalian ribosomal protein L11 and bacterial L5; RPL11B has a paralog, RPL11A, that arose from the whole genome duplication cytoplasmic translation|ribosomal large subunit assembly structural constituent of ribosome cytosolic large ribosomal subunit
YGR239C YGR239C PEX21 hom Verified 0.432850555357425 0.332561671400874 no 1544 0.350381805680287 1185 NA FT PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION Peroxin required for peroxisomal matrix protein targeting; acts on proteins containing the PTS2 targeting sequence; interacts with Pex7p; partially redundant with Pex18p; relative distribution to cytoplasmic foci increases upon DNA replication stress protein import into peroxisome matrix|positive regulation of protein binding protein binding cytosol|peroxisome
YBR218C YBR218C PYC2 hom Verified 0.431761755045772 0.332957289305559 no 1545 0.343915702907867 1171 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc1p; mutations in the human homolog are associated with lactic acidosis; PYC2 has a paralog, PYC1, that arose from the whole genome duplication NADPH regeneration|gluconeogenesis pyruvate carboxylase activity cytosol
YGR219W_d YGR219W YGR219W hom Dubious 0.431374401727042 0.333098079838438 no 1546 0.350591652566905 1156 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRPL9/YGR220C Unknown Unknown Unknown
YHL037C_d YHL037C YHL037C hom Dubious 0.431089826206871 0.333201528923829 no 1547 0.32029541308985 1035 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR127W YDR127W ARO1 hom Verified 0.430651665231494 0.333360834309878 no 1548 0.411131256087379 1347 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids aromatic amino acid family biosynthetic process shikimate kinase activity|shikimate 3-dehydrogenase (NADP+) activity|3-phosphoshikimate 1-carboxyvinyltransferase activity|3-dehydroquinate dehydratase activity|3-dehydroquinate synthase activity cytoplasm
YBR077C YBR077C SLM4 hom Verified 0.430496563438919 0.333417233007119 no 1549 0.360966689938252 1182 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|SIGNALING Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4 signal transduction|microautophagy phosphatidylinositol-3,4-bisphosphate binding fungal-type vacuole membrane|EGO complex|late endosome membrane|cytoplasm
YOR248W_d YOR248W YOR248W hom Dubious 0.430387400924793 0.333456929349164 no 1550 0.329489039402966 1096 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGR112W YGR112W SHY1 hom Verified 0.429917673650881 0.333627764338274 no 1551 0.315932030103009 1076 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome mitochondrial respiratory chain complex IV assembly|aerobic respiration unfolded protein binding mitochondrion|integral to membrane|mitochondrial inner membrane
YPR069C YPR069C SPE3 hom Verified 0.429399894955639 0.333816115112355 no 1552 0.366552223086582 1217 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM NUCLEUS Spermidine synthase, involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells spermidine biosynthetic process|pantothenate biosynthetic process spermidine synthase activity nucleus|cytoplasm
YOR228C YOR228C YOR228C hom Verified 0.428381964904792 0.334186526482447 no 1553 0.342045333809648 1151 NA FT MITOCHONDRION Protein of unknown function, localized to the mitochondrial outer membrane biological_process molecular_function mitochondrial outer membrane|mitochondrion|integral to membrane
YLR200W YLR200W YKE2 hom Verified 0.428288134613843 0.334220678229542 no 1554 0.366715336302096 1224 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS NUCLEUS Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin protein folding|tubulin complex assembly tubulin binding prefoldin complex|cytoplasm
YNL228W_d YNL228W YNL228W hom Dubious 0.426849343879479 0.334744531776587 no 1555 0.352702625463362 1170 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF YNL227C/JJJ1 Unknown Unknown Unknown
YLR428C_d YLR428C YLR428C hom Dubious 0.426788895846866 0.334766547529023 no 1556 0.343831579755011 1142 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CRN1 Unknown Unknown Unknown
YNR007C YNR007C ATG3 hom Verified 0.426374534128928 0.33491747732303 no 1557 0.34403574578848 1164 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS E2-like enzyme involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; plays a role in formation of Atg8p-phosphatidylethanolamine conjugates, which are involved in membrane dynamics during autophagy and Cvt; interaction with Atg8p is regulated by its acetylation by Esa1p (catalytic subunit of NuA4 histone acetyltransferase complex) while attenuation of Atg3 acetylation is mediated by histone deacetylase Rpd3p C-terminal protein lipidation|piecemeal microautophagy of nucleus|mitochondrion degradation|CVT pathway|autophagic vacuole assembly Atg8 ligase activity cytosol|cytoplasm
YER074W YER074W RPS24A hom Verified 0.426137560439478 0.335003806141501 no 1558 0.318462215846982 1088 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION NUCLEUS|MITOCHONDRION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24A has a paralog, RPS24B, that arose from the whole genome duplication cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit|mitochondrion
YMR267W YMR267W PPA2 hom Verified 0.426065491620957 0.335030062329293 no 1559 0.349320112516707 1175 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate aerobic respiration inorganic diphosphatase activity mitochondrion
YNL166C YNL166C BNI5 hom Verified 0.425134253443337 0.335369404477757 no 1560 0.314948740163506 1039 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner septin ring assembly|cytokinesis molecular_function cellular bud neck septin ring|cellular bud neck
YGR205W YGR205W TDA10 hom Verified 0.424157466448251 0.335725488952013 no 1561 0.312504307417842 1043 NA FT NUCLEUS ATP-binding protein of unknown function; crystal structure resembles that of E.coli pantothenate kinase and other small kinases; null mutant is sensitive to expression of the top1-T722A allele biological_process ATP binding nucleus|cytoplasm
YGL230C_p YGL230C YGL230C hom Uncharacterized 0.423218919715399 0.336067772076598 no 1562 0.323466498287901 1085 NA Putative protein of unknown function; non-essential gene biological_process molecular_function cellular_component
YDL033C YDL033C SLM3 hom Verified 0.42223821397011 0.336425575655665 no 1563 0.345460562074026 1181 NA FT RNA PROCESSING|MITOCHONDRION ORGANIZATION MITOCHONDRION tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF) mitochondrial tRNA thio-modification tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity mitochondrion
YGL218W_d YGL218W YGL218W hom Dubious 0.42174250993004 0.336606486182256 no 1564 0.367522222478615 1208 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 93% of ORF overlaps the verified gene MDM34; deletion in cyr1 mutant results in loss of stress resistance Unknown Unknown Unknown
YKL005C YKL005C BYE1 hom Verified 0.420972288677107 0.336887658646419 no 1565 0.331213996761856 1082 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Negative regulator of transcription elongation, contains a TFIIS-like domain and a PHD finger, multicopy suppressor of temperature-sensitive ess1 mutations, probably binds RNA polymerase II large subunit negative regulation of transcription from RNA polymerase II promoter methylated histone residue binding nucleus
YGL037C YGL037C PNC1 hom Verified 0.420962416624087 0.336891263072469 no 1566 0.318284442717808 1051 NA FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|GENE SILENCING NUCLEUS Nicotinamidase that converts nicotinamide to nicotinic acid; part of the NAD(+) salvage pathway; required for life span extension by calorie restriction; PNC1 expression responds to all known stimuli that extend replicative life span; protein increases in abundance and relative distribution to cytoplasmic foci decreases upon DNA replication stress replicative cell aging|chromatin silencing at rDNA|nicotinate nucleotide salvage|chromatin silencing at telomere nicotinamidase activity nucleus|peroxisome|cytoplasm
YER115C YER115C SPR6 hom Verified 0.420900639451246 0.336913819131336 no 1567 0.344375874365701 1139 NA FT CELL CYCLE Protein of unknown function, expressed during sporulation; not required for sporulation, but gene exhibits genetic interactions with other genes required for sporulation ascospore formation molecular_function cellular_component
YKL134C YKL134C OCT1 hom Verified 0.420810526545081 0.336946722174559 no 1568 0.331773380139244 1106 NA FT PROTEIN LOCALIZATION|ION HOMEOSTASIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS MITOCHONDRION Mitochondrial intermediate peptidase, cleaves destabilizing N-terminal residues of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may contribute to mitochondrial iron homeostasis cellular iron ion homeostasis|protein processing involved in protein targeting to mitochondrion metalloendopeptidase activity mitochondrion
YPL039W_p YPL039W YPL039W hom Uncharacterized 0.420150487461714 0.33718776113306 no 1569 0.347182496016836 1174 NA Putative protein of unknown function; YPL039W is not an essential gene biological_process molecular_function cellular_component
YPL070W YPL070W MUK1 hom Verified 0.418641981942556 0.337738901488408 no 1570 0.330449453439039 1091 NA Cytoplasmic protein of unknown function containing a Vps9 domain; computational analysis of large-scale protein-protein interaction data suggests a possible role in transcriptional regulation biological_process molecular_function cytoplasm
YKL003C YKL003C MRP17 hom Verified 0.418483707517213 0.337796748074229 no 1571 0.343985557796832 1177 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YJL063C YJL063C MRPL8 hom Verified 0.41791094223043 0.338006115968748 no 1572 0.352344675543396 1214 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial genome maintenance|mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YOL136C YOL136C PFK27 hom Verified 0.417668100823303 0.338094899041292 no 1573 0.318233246743141 1067 NA FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY 6-phosphofructo-2-kinase, catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A regulation of glycolysis|fructose 2,6-bisphosphate metabolic process 6-phosphofructo-2-kinase activity cytoplasm
YLR435W YLR435W TSR2 hom Verified 0.41705646814554 0.338318552482929 no 1574 0.35116086752446 1188 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Protein with a potential role in pre-rRNA processing maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function nucleus|cytoplasm
YNL154C YNL154C YCK2 hom Verified 0.41680095082444 0.338412003450754 no 1575 0.345164817053876 1182 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL DIVISION|PROTEIN PHOSPHORYLATION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; YCK2 has a paralog, YCK1, that arose from the whole genome duplication endocytosis|cell morphogenesis|protein phosphorylation|cytokinesis|response to glucose stimulus protein serine/threonine kinase activity|protein kinase activity plasma membrane|cellular bud neck|mating projection
YGL070C YGL070C RPB9 hom Verified 0.416733103524603 0.338436819080307 no 1576 0.367666624930731 1221 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE NUCLEUS RNA POL II, HOLOENZYME RNA polymerase II subunit B12.6; contacts DNA; mutations affect transcription start site selection and fidelity of transcription transcription initiation from RNA polymerase II promoter|maintenance of transcriptional fidelity during DNA-dependent transcription elongation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|response to DNA damage stimulus|transcription from RNA polymerase II promoter RNA-directed RNA polymerase activity DNA-directed RNA polymerase II, core complex
YHR063C YHR063C PAN5 hom Verified 0.41658994229291 0.338489183614994 no 1577 0.354802912700489 1185 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM 2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panE pantothenate biosynthetic process 2-dehydropantoate 2-reductase activity cytoplasm
YPL234C YPL234C VMA11 hom Verified 0.416355308198278 0.338575013220344 no 1578 0.350015976204128 1156 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Vacuolar ATPase V0 domain subunit c', involved in proton transport activity; hydrophobic integral membrane protein (proteolipid) containing four transmembrane segments; N and C termini are in the vacuolar lumen vacuolar acidification proton-transporting ATPase activity, rotational mechanism vacuolar proton-transporting V-type ATPase, V0 domain|integral to membrane|fungal-type vacuole
YCL061C YCL061C MRC1 hom Verified 0.415998092215783 0.338705699616581 no 1579 0.355433433461582 1212 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|GENE SILENCING NUCLEUS|CHROMOSOME S-phase checkpoint protein required for DNA replication; interacts with and stabilizes Pol2p at stalled replication forks during stress, where it forms a pausing complex with Tof1p and is phosphorylated by Mec1p; protects uncapped telomeres maintenance of DNA repeat elements|intra-S DNA damage checkpoint|DNA repair|DNA replication checkpoint|telomere maintenance|replication fork protection|DNA replication|mitotic sister chromatid cohesion|chromatin silencing at silent mating-type cassette|chromatin silencing at telomere molecular_function nuclear chromosome|replication fork protection complex|nucleus|nuclear replication fork
YDR126W YDR126W SWF1 hom Verified 0.415801144119653 0.338777760793802 no 1580 0.34354666988577 1134 NA FF|FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|CYTOSKELETON Palmitoyltransferase that acts on transmembrane proteins, including the SNAREs Snc1p, Syn8p, Tlg1p and likely all SNAREs; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; may have a role in vacuole fusion ascospore wall assembly|cortical actin cytoskeleton organization|establishment of cell polarity|vacuole fusion, non-autophagic|regulation of exocytosis|protein palmitoylation palmitoyltransferase activity integral to membrane|actin filament bundle|nuclear outer membrane-endoplasmic reticulum membrane network|actin cortical patch
YOR356W YOR356W CIR2 hom Verified 0.415478439766087 0.338895847580534 no 1581 0.335173395990904 1135 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Putative ortholog of human electron transfer flavoprotein dehydrogenase (ETF-dH); found in a large supramolecular complex with other mitochondrial dehydrogenases; may have a role in oxidative stress response biological_process molecular_function mitochondrion
YDR056C_p YDR056C YDR056C hom Uncharacterized 0.414744031634341 0.33916464760269 no 1582 0.33195935913066 1109 NA FT ENDOPLASMIC RETICULUM Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR056C is not an essential protein biological_process molecular_function endoplasmic reticulum
YKL133C_p YKL133C YKL133C hom Uncharacterized 0.412163574631964 0.340109766756324 no 1583 0.354614721201404 1174 NA Putative protein of unknown function; has similarity to Mgr3p, but unlike MGR3, is not required for growth of cells lacking the mitochondrial genome (null mutation does not confer a petite-negative phenotype) biological_process molecular_function cellular_component
YDR312W YDR312W SSF2 hom Verified 0.411575125678286 0.340325433304677 no 1584 0.307292570013386 1039 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS NUCLEUS Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication conjugation with cellular fusion|ribosomal large subunit assembly rRNA binding nucleolus
YDR132C YDR132C YDR132C hom Verified 0.411408506313313 0.340386508796375 no 1585 0.341682905444222 1134 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS NUCLEUS|PLASMA MEMBRANE Protein of unknown function; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; YDR132C has a paralog, YLR108C, that arose from the whole genome duplication biological_process molecular_function nucleus|cytoplasm
YGR235C YGR235C MOS2 hom Verified 0.411302445797523 0.340425388199877 no 1586 0.362667876867202 1217 NA FT MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial inner membrane protein; non-essential component of the mitochondrial inner membrane organizing system (MINOS, MitOS, or MICOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture cristae formation molecular_function mitochondrion|mitochondrial crista junction|integral to mitochondrial inner membrane
YHR130C_d YHR130C YHR130C hom Dubious 0.411061394831131 0.340513758378685 no 1587 0.343731178542133 1158 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOR235W_d YOR235W IRC13 hom Dubious 0.410901078514609 0.340572535784094 no 1588 0.368144485329528 1222 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays increased levels of spontaneous Rad52 foci Unknown Unknown Unknown
YEL036C YEL036C ANP1 hom Verified 0.410686751357553 0.340651121445965 no 1589 0.375749515383375 1236 NA FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol protein N-linked glycosylation alpha-1,6-mannosyltransferase activity|mannosyltransferase activity alpha-1,6-mannosyltransferase complex|Golgi cis cisterna
YHR135C YHR135C YCK1 hom Verified 0.410572291017184 0.340693092557255 no 1590 0.336857679178141 1138 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL DIVISION|PROTEIN PHOSPHORYLATION ENDOPLASMIC RETICULUM|MITOCHONDRION|PLASMA MEMBRANE Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; YCK1 has a paralog, YCK2, that arose from the whole genome duplication cell morphogenesis|endocytosis|protein phosphorylation|cytokinesis|response to glucose stimulus protein serine/threonine kinase activity|protein kinase activity mitochondrion|endoplasmic reticulum|plasma membrane
YDR263C YDR263C DIN7 hom Verified 0.410493420988142 0.340722014314256 no 1591 0.350315777122423 1169 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination DNA repair nuclease activity mitochondrion
YIL154C YIL154C IMP2' hom Verified 0.408484347931757 0.341459059707544 no 1592 0.385302553262376 1304 NA FF|FT RESPONSE TO DNA DAMAGE|ION HOMEOSTASIS|CARBOHYDRATE METABOLISM|ION HOMEOSTASIS Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeat DNA repair|cellular carbohydrate metabolic process transcription coactivator activity cytoplasm
YPL274W YPL274W SAM3 hom Verified 0.408440506434538 0.341475150086025 no 1593 0.38525282063085 1276 NA FT ENDOPLASMIC RETICULUM|PLASMA MEMBRANE High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p spermidine transport|putrescine transport|S-adenosylmethionine transport S-adenosylmethionine transmembrane transporter activity|spermidine transmembrane transporter activity|putrescine transmembrane transporter activity integral to membrane|plasma membrane
YBL071W-A YBL071W-A KTI11 hom Verified 0.405523130856103 0.34254650969899 no 1594 0.391449369075052 1315 NA FT RNA PROCESSING NUCLEUS Zn-ribbon protein that co-purifies with Dph1 and Dph2 in a complex required for synthesis of diphthamide on translation factor eEF2 and with Elongator subunits Iki3p, Elp2p, and Elp3p involved in modification of wobble nucleosides in tRNAs peptidyl-diphthamide biosynthetic process from peptidyl-histidine|tRNA wobble uridine modification electron carrier activity|iron ion binding|zinc ion binding nucleus|cytoplasm
YNL219C YNL219C ALG9 hom Verified 0.405368454785882 0.342603347486697 no 1595 0.35320838903369 1160 NA FT LIPID METABOLISM|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Mannosyltransferase, involved in N-linked glycosylation; catalyzes both the transfer of seventh mannose residue on B-arm and ninth mannose residue on the C-arm from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation dolichol-linked oligosaccharide biosynthetic process|protein glycosylation mannosyltransferase activity integral to membrane|endoplasmic reticulum
YLR427W YLR427W MAG2 hom Verified 0.405227847360246 0.34265501865549 no 1596 0.357788754711107 1224 NA Cytoplasmic protein of unknown function; induced in response to mycotoxin patulin; ubiquitinated protein similar to the human ring finger motif protein RNF10; predicted to be involved in repair of alkylated DNA due to interaction with MAG1 biological_process molecular_function cytoplasm
YMR194C-A_d YMR194C-A YMR194C-A hom Dubious 0.403899672517194 0.343143248587818 no 1597 0.337240963411008 1135 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YNR032W YNR032W PPG1 hom Verified 0.403843118722297 0.343164043278986 no 1598 0.34763513256649 1162 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Putative serine/threonine protein phosphatase of the type 2A-like phosphatase family, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases glycogen metabolic process|protein dephosphorylation protein serine/threonine phosphatase activity nucleus|cytoplasm
YJL108C YJL108C PRM10 hom Verified 0.403697197735419 0.343217700260168 no 1599 0.357223065599166 1188 NA Pheromone-regulated protein, proposed to be involved in mating; predicted to have 5 transmembrane segments; induced by treatment with 8-methoxypsoralen and UVA irradiation biological_process molecular_function integral to membrane
YNL080C YNL080C EOS1 hom Verified 0.401911509908485 0.343874575849608 no 1600 0.358636620384922 1192 NA FT CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein involved in N-glycosylation; deletion mutation confers sensitivity to exidative stress and shows synthetic lethality with mutations in the spindle checkpoint genes BUB3 and MAD1; YNL080C is not an essential gene cellular response to oxidative stress|protein N-linked glycosylation molecular_function integral to membrane|endoplasmic reticulum membrane
YIR007W_p YIR007W YIR007W hom Uncharacterized 0.401491317019165 0.344029214841215 no 1601 0.335014244296155 1080 NA FT CARBOHYDRATE METABOLISM Putative glycosidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YIR007W is a non-essential gene biological_process molecular_function cytoplasm
YKL156W YKL156W RPS27A hom Verified 0.401323306722334 0.344091053135364 no 1602 0.354316031272094 1177 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27A has a paralog, RPS27B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress cytoplasmic translation|ribosomal small subunit assembly|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit|cytoplasm
YKR026C YKR026C GCN3 hom Verified 0.400907626595292 0.344244067329782 no 1603 0.380111095493616 1301 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression regulation of translational initiation enzyme regulator activity|guanyl-nucleotide exchange factor activity|translation initiation factor activity eukaryotic translation initiation factor 2B complex|guanyl-nucleotide exchange factor complex
YKL120W YKL120W OAC1 hom Verified 0.400644369666992 0.344340986877853 no 1604 0.338355474262843 1146 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Mitochondrial inner membrane transporter, transports oxaloacetate, sulfate, thiosulfate, and isopropylmalate; member of the mitochondrial carrier family sulfate transport|oxaloacetate transport|isopropylmalate transport secondary active sulfate transmembrane transporter activity|oxaloacetate secondary active transmembrane transporter activity|isopropylmalate transmembrane transporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YGL211W YGL211W NCS6 hom Verified 0.39863837099347 0.345079842121773 no 1605 0.345582005152331 1201 NA FT RNA PROCESSING MITOCHONDRION Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae tRNA wobble position uridine thiolation|protein urmylation|tRNA wobble uridine modification tRNA binding cytosol|mitochondrion
YFR018C_p YFR018C YFR018C hom Uncharacterized 0.398406490711208 0.345165287097901 no 1606 0.335437386438938 1131 NA FT PROTEOLYSIS Putative protein of unknown function biological_process molecular_function cellular_component
YAL046C YAL046C AIM1 hom Verified 0.398284937455118 0.345210081102331 no 1607 0.35163504678213 1164 NA Protein involved in mitochondrial function or organization; null mutant displays elevated frequency of mitochondrial genome loss biological_process molecular_function cellular_component
YOR032C YOR032C HMS1 hom Verified 0.396814096263924 0.345752277523646 no 1608 0.354313761737554 1216 NA FT NUCLEUS Basic helix-loop-helix (bHLH) protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant pseudohyphal growth sequence-specific DNA binding transcription factor activity cellular_component
YBR078W YBR078W ECM33 hom Verified 0.39643958600693 0.345890383899454 no 1609 0.4172730416148 1367 NA FF|FT CELL WALL ORG/BIOGENESIS MITOCHONDRION|PLASMA MEMBRANE GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p and Pst1p fungal-type cell wall organization molecular_function mitochondrion|fungal-type cell wall|plasma membrane
YEL013W YEL013W VAC8 hom Verified 0.396197198529833 0.345979778914581 no 1610 0.335264989069413 1134 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Phosphorylated and palmitoylated vacuolar membrane protein that interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions piecemeal microautophagy of nucleus|vacuole inheritance|CVT vesicle assembly|vacuole fusion, non-autophagic|macroautophagy|nucleus-vacuole junction assembly protein anchor fungal-type vacuole membrane|nucleus-vacuole junction|Myo2p-Vac17p-Vac8p transport complex
YBR043C YBR043C QDR3 hom Verified 0.395025168721998 0.346412156703441 no 1611 0.320598806897069 1094 NA FT PLASMA MEMBRANE Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; has a role in polyamine homeostasis; expression is upregulated under polyamine stress; required for resistance to quinidine, barban, cisplatin, and bleomycin drug transmembrane transport|polyamine homeostasis drug transmembrane transporter activity|polyamine transmembrane transporter activity integral to membrane|plasma membrane
YOR187W YOR187W TUF1 hom Verified 0.394562174883911 0.346583016647948 no 1612 0.418260975036782 1358 NA FT TRANSLATION|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial translation elongation factor Tu; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans mitochondrial translational elongation|mitochondrial translation GTPase activity|translation elongation factor activity mitochondrion|mitochondrial matrix
YLR461W YLR461W PAU4 hom Verified 0.392399888403039 0.347381384243769 no 1613 0.351898127444272 1178 NA Member of the seripauperin multigene family encoded mainly in subtelomeric regions; active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme biological_process molecular_function cellular_component
YGL007C-A_p YGL007C-A YGL007C-A hom Uncharacterized 0.392354688022875 0.347398080541399 no 1614 0.347950720034872 1164 NA Putative protein of unknown function, identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; deletion exhibits slow-growth phenotype; computationally predicted to have a role in cell budding biological_process molecular_function cellular_component
YNL211C_p YNL211C YNL211C hom Uncharacterized 0.392004206708425 0.347527552781619 no 1615 0.345328993944288 1167 NA FT MITOCHONDRION Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL211C is not an essential gene biological_process molecular_function mitochondrion
YJR135C YJR135C MCM22 hom Verified 0.391629322027516 0.34766605962492 no 1616 0.340963605118481 1138 NA FT CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME KINETOCHORE Outer kinetochore protein and component of the Ctf3 subcomplex; binds to centromeric DNA in a Ctf19p-dependent manner; involved in chromosome segregation and minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-K and fission yeast sim4 chromosome segregation|establishment of mitotic sister chromatid cohesion molecular_function condensed nuclear chromosome kinetochore
YDL172C_d YDL172C YDL172C hom Dubious 0.389683401818479 0.348385335801397 no 1617 0.368555775605441 1212 NA Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YBR120C YBR120C CBP6 hom Verified 0.389460908076339 0.348467611617097 no 1618 0.344580025385342 1141 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex positive regulation of mitochondrial translation|mitochondrial respiratory chain complex III assembly ribosome binding mitochondrion|mitochondrial ribosome
YJL030W YJL030W MAD2 hom Verified 0.389284057392344 0.348533014202107 no 1619 0.330901549394902 1116 NA FT CELL CYCLE|CELL DIVISION ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME NUCLEAR PORE|KINETOCHORE Component of the spindle-assembly checkpoint complex; delays the onset of anaphase in cells with defects in mitotic spindle assembly; forms a complex with Mad1p; regulates APC/C activity during prometaphase and metaphase of meiosis I chromosome decondensation|mitotic cell cycle spindle assembly checkpoint|mitotic cell cycle G2/M transition decatenation checkpoint molecular_function mitotic checkpoint complex|condensed nuclear chromosome kinetochore|nuclear pore
YKL174C YKL174C TPO5 hom Verified 0.389093327908435 0.34860355446529 no 1620 0.335545301556735 1097 NA FT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Protein involved in excretion of putrescine and spermidine; putative polyamine transporter in the Golgi or post-Golgi vesicles polyamine transport polyamine transmembrane transporter activity integral to membrane|Golgi apparatus
YPL089C YPL089C RLM1 hom Verified 0.388651683044377 0.348766914510518 no 1621 0.387128948719319 1287 NA FT TRANSCRIPTION FROM RNA POL II|SIGNALING NUCLEUS MADS-box transcription factor; component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p; RLM1 has a paralog, SMP1, that arose from the whole genome duplication signal transduction|positive regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|DNA binding, bending|sequence-specific DNA binding nucleus
YLR382C YLR382C NAM2 hom Verified 0.386082527540887 0.349717774780263 no 1622 0.369007818672584 1190 NA FT KETONE METABOLISM|RNA PROCESSING|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial leucyl-tRNA synthetase, also has a direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance Group I intron splicing|leucyl-tRNA aminoacylation|mitochondrial translation mRNA binding|leucine-tRNA ligase activity mitochondrion
YJL024C YJL024C APS3 hom Verified 0.385116778061038 0.350075448921017 no 1623 0.362756098742122 1200 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress Golgi to vacuole transport|vesicle-mediated transport molecular_function AP-3 adaptor complex
YLR257W YLR257W YLR257W hom Verified 0.384312096581463 0.350373571686458 no 1624 0.35296210144869 1164 NA Protein of unknown function; protein abundance increases in response to DNA replication stress biological_process molecular_function cytoplasm
YJL112W YJL112W MDV1 hom Verified 0.38398192116977 0.350495923555325 no 1625 0.36398148035571 1213 NA FT MITOCHONDRION ORGANIZATION|PEROXISOME ORGANIZATION MITOCHONDRION Peripheral protein of cytosolic face of mitochondrial outer membrane; required for mitochondrial fission; interacts with Fis1p and with the dynamin-related GTPase Dnm1p; contains WD repeats; MDV1 has a paralog, CAF4, that arose from the whole genome duplication peroxisome fission|mitochondrial fission|mitochondrial genome maintenance ubiquitin binding mitochondrial outer membrane|mitochondrion
YER091C-A_d YER091C-A YER091C-A hom Dubious 0.383815642708104 0.3505575466178 no 1626 0.362462329925738 1204 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YER060W-A YER060W-A FCY22 hom Verified 0.383740960375236 0.350585225289188 no 1627 0.323157221572601 1058 NA Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function transmembrane transport nucleobase transmembrane transporter activity integral to membrane
YHR116W YHR116W COX23 hom Verified 0.383642992134267 0.350621535357055 no 1628 0.352434149732648 1159 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs mitochondrial respiratory chain complex assembly molecular_function mitochondrion|cytoplasm
YGR129W YGR129W SYF2 hom Verified 0.383288165193545 0.350753056644075 no 1629 0.372284893820064 1259 NA FT RNA PROCESSING NUCLEUS Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; isy1 syf2 cells have defective spindles activiating cell cycle arrest mRNA splicing, via spliceosome first spliceosomal transesterification activity|second spliceosomal transesterification activity U2-type post-mRNA release spliceosomal complex|Prp19 complex|U2-type prespliceosome|U2-type catalytic step 2 spliceosome|U2-type catalytic step 1 spliceosome
YPL241C YPL241C CIN2 hom Verified 0.382979232199198 0.350867581302185 no 1630 0.350597203400104 1202 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS CYTOSKELETON GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2 protein folding|tubulin complex assembly|tubulin complex biogenesis GTPase activator activity cellular_component
YPL080C_d YPL080C YPL080C hom Dubious 0.382369285619867 0.351093734590857 no 1631 0.308591961154319 1025 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGL205W YGL205W POX1 hom Verified 0.382331573106588 0.351107719201678 no 1632 0.331264467304576 1098 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix fatty acid beta-oxidation using acyl-CoA oxidase|fatty acid beta-oxidation acyl-CoA oxidase activity peroxisomal matrix
YLR373C YLR373C VID22 hom Verified 0.380674612628595 0.351722354591375 no 1633 0.362800362027007 1203 NA FT PROTEIN LOCALIZATION NUCLEUS|PLASMA MEMBRANE Glycosylated integral membrane protein localized to the plasma membrane; plays a role in fructose-1,6-bisphosphatase (FBPase) degradation; involved in FBPase transport from the cytosol to Vid (vacuole import and degradation) vesicles vacuolar protein catabolic process molecular_function integral to plasma membrane
YDR205W YDR205W MSC2 hom Verified 0.380132062583436 0.351923693265691 no 1634 0.352835625352047 1185 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids cellular zinc ion homeostasis|zinc ion transport|transmembrane transport zinc ion transmembrane transporter activity|metal ion transmembrane transporter activity integral to membrane|endoplasmic reticulum
YKR010C YKR010C TOF2 hom Verified 0.380103637005473 0.351934243056691 no 1635 0.339807685628791 1156 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CHROMOSOME SEGREGATION|GENE SILENCING NUCLEUS|MITOCHONDRION Protein required for rDNA silencing and mitotic rDNA condensation; stimulates Cdc14p phosphatase activity and biphasic release to promote rDNA repeat segregation; required for condensin recruitment to the replication fork barrier site; TOF2 has a paralog, NET1, that arose from the whole genome duplication nucleolus organization|rDNA condensation|chromatin silencing at rDNA|protein localization to nucleolar rDNA repeats phosphatase activator activity mitochondrion|nucleolus
YPL267W YPL267W ACM1 hom Verified 0.379282362516492 0.352239097809908 no 1636 0.352209270970457 1169 NA FT CELL CYCLE|CELL DIVISION NUCLEUS Pseudosubstrate inhibitor of the anaphase-promoting complex/cyclosome (APC/C), that suppresses APC/C [Cdh1]-mediated proteolysis of mitotic cyclins; associates with Cdh1p, Bmh1p and Bmh2p; cell cycle regulated protein negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle ubiquitin-protein ligase inhibitor activity nucleus|cytoplasm
YBR071W YBR071W YBR071W hom Verified 0.377911684358309 0.352748101084023 no 1637 0.352122108406588 1154 NA FT SITE OF POLARIZED GROWTH Protein of unknown function found in the cytoplasm and bud neck; mRNA expression may be regulated by the cell cycle and/or cell wall stress; overexpression of YBR071W affects endocytic protein trafficking biological_process molecular_function cellular bud neck|cytoplasm
YPR131C YPR131C NAT3 hom Verified 0.376678484371063 0.353206277046454 no 1638 0.352573005809344 1157 NA FT MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION Catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met mitochondrion inheritance|N-terminal peptidyl-methionine acetylation|cytoskeleton organization peptide alpha-N-acetyltransferase activity NatB complex|cytoplasm
YER117W YER117W RPL23B hom Verified 0.375903767270209 0.35349421985276 no 1639 0.351650711628125 1169 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L23B; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23B has a paralog, RPL23A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YAL047C YAL047C SPC72 hom Verified 0.37583400665704 0.35352015223133 no 1640 0.359743994994178 1199 NA FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION NUCLEUS|CYTOSKELETON Component of the cytoplasmic Tub4p (gamma-tubulin) complex, binds spindle pole bodies and links them to microtubules; has roles in astral microtubule formation and stabilization microtubule nucleation|nuclear migration along microtubule|mitotic cell cycle spindle orientation checkpoint|mitotic spindle elongation|mitotic sister chromatid segregation structural constituent of cytoskeleton outer plaque of spindle pole body
YKR098C YKR098C UBP11 hom Verified 0.375255008810387 0.353735411537076 no 1641 0.355214372443534 1215 NA FT PROTEOLYSIS Ubiquitin-specific protease that cleaves ubiquitin from ubiquitinated proteins biological_process ubiquitin-specific protease activity cellular_component
YPR050C_d YPR050C YPR050C hom Dubious 0.374833853371027 0.353892017722023 no 1642 0.378573845458613 1259 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MAK3/YPR051W Unknown Unknown Unknown
YGL166W YGL166W CUP2 hom Verified 0.374718871387283 0.353934777943189 no 1643 0.362868850455298 1192 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations; CUP2 has a paralog, HAA1, that arose from the whole genome duplication regulation of transcription from RNA polymerase II promoter|response to copper ion RNA polymerase II core promoter proximal region sequence-specific DNA binding|copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity|copper ion binding nucleus
YGL034C_d YGL034C YGL034C hom Dubious 0.373760219842445 0.354291358960422 no 1644 0.368626631004758 1205 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOR082C_d YOR082C YOR082C hom Dubious 0.373618810778906 0.354343968443447 no 1645 0.351867051811378 1156 NA Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene YOR083W Unknown Unknown Unknown
YHR191C YHR191C CTF8 hom Verified 0.373287183172924 0.354467357270275 no 1646 0.408659200310431 1339 NA FT CELL CYCLE|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion maintenance of DNA trinucleotide repeats|mitotic sister chromatid cohesion molecular_function Ctf18 RFC-like complex
YBR133C YBR133C HSL7 hom Verified 0.373145953553934 0.354519909274285 no 1647 0.361025688617242 1216 NA FT CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION SITE OF POLARIZED GROWTH Protein arginine N-methyltransferase; exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p; relocalizes away from bud neck upon DNA replication stress G2/M transition of mitotic cell cycle|regulation of cell cycle protein-arginine omega-N symmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity cellular bud neck
YDR298C YDR298C ATP5 hom Verified 0.372983350650053 0.354580417777522 no 1648 0.360986361973186 1216 NA FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS MITOCHONDRION Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated ATP synthesis coupled proton transport hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase, stator stalk|mitochondrial proton-transporting ATP synthase complex
YCL026C-A YCL026C-A FRM2 hom Verified 0.372728155028671 0.354675389686411 no 1649 0.332397235227203 1149 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS NUCLEUS Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin cellular response to oxidative stress|negative regulation of fatty acid metabolic process oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor nucleus|cytoplasm
YAL056C-A_d YAL056C-A YAL056C-A hom Dubious 0.371371055394953 0.355180590512424 no 1650 0.374034612388474 1253 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YNL077W YNL077W APJ1 hom Verified 0.370859341072221 0.355371150057464 no 1651 0.3756715372664 1254 NA FT NUCLEUS|MITOCHONDRION Chaperone with a role in SUMO-mediated protein degradation; member of the DnaJ-like family; conserved across eukaryotes; overexpression interferes with propagation of the [Psi+] prion; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress biological_process unfolded protein binding mitochondrion|nucleus|cytoplasm
YKL017C YKL017C HCS1 hom Verified 0.370575504956142 0.35547686463267 no 1652 0.304502169245788 1018 NA FT NUCLEUS|CHROMOSOME Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities lagging strand elongation ATP-dependent 5'-3' DNA helicase activity DNA helicase A complex|alpha DNA polymerase:primase complex
YGL222C YGL222C EDC1 hom Verified 0.36833982972623 0.356309928558317 no 1653 0.349845357758228 1177 NA FT RNA PROCESSING|TRANSLATION NUCLEUS RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress deadenylation-dependent decapping of nuclear-transcribed mRNA|positive regulation of translation in response to stress mRNA binding nucleus|cytoplasm
YER151C YER151C UBP3 hom Verified 0.368238392468528 0.356347742712748 no 1654 0.373775375303868 1228 NA FT VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS Ubiquitin-specific protease involved in transport and osmotic response; interacts with Bre5p to co-regulate anterograde and retrograde transport between the ER and Golgi; involved in transcription elongation in response to osmostress through phosphorylation at Ser695 by Hog1p; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin; also has mRNA binding activity; protein abundance increases in response to DNA replication stress protein deubiquitination|ribophagy|regulation of ER to Golgi vesicle-mediated transport|regulation of response to osmotic stress ubiquitin-specific protease activity|mRNA binding cytoplasm
YIL077C_p YIL077C YIL077C hom Uncharacterized 0.367520875725517 0.356615261559292 no 1655 0.371250529585746 1244 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) biological_process molecular_function mitochondrion
YGL148W YGL148W ARO2 hom Verified 0.366974240598996 0.356819116284053 no 1656 0.421953170787781 1396 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM Bifunctional chorismate synthase and flavin reductase; catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids; protein abundance increases in response to DNA replication stress aromatic amino acid family biosynthetic process chorismate synthase activity|riboflavin reductase (NADPH) activity cytoplasm
YFL036W YFL036W RPO41 hom Verified 0.366340452724713 0.35705552377265 no 1657 0.362414214506608 1180 NA FT MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation transcription from mitochondrial promoter|mitochondrial genome maintenance DNA-directed RNA polymerase activity mitochondrial nucleoid|mitochondrion|mitochondrial DNA-directed RNA polymerase complex|mitochondrial matrix
YIR035C_p YIR035C YIR035C hom Uncharacterized 0.365690994870597 0.357297833225681 no 1658 0.334070862968292 1117 NA FT OXIDATION-REDUCTION PROCESS Putative cytoplasmic short-chain dehydrogenase/reductase biological_process molecular_function integral to membrane|cytoplasm
YGR223C YGR223C HSV2 hom Verified 0.365319812899522 0.357436345201808 no 1659 0.360842500194436 1178 NA FT MEMBRANE ORGANIZATION|RESPONSE TO NUTRIENT LEVELS Phosphatidylinositol 3,5-bisphosphate-binding protein, plays a role in micronucleophagy; belongs to the PROPPIN family of proteins; predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization piecemeal microautophagy of nucleus phosphatidylinositol binding endosome|fungal-type vacuole|extrinsic to membrane|cytoplasm
YGR110W YGR110W CLD1 hom Verified 0.364830663985821 0.357618906950246 no 1660 0.369697920580529 1252 NA FT LIPID METABOLISM MITOCHONDRION Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58 cardiolipin acyl-chain remodeling|cardiolipin metabolic process phospholipase A2 activity mitochondrion
YER038W-A_d YER038W-A YER038W-A hom Dubious 0.364747229538835 0.357650049879717 no 1661 0.365915303607454 1213 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 99% of ORF overlaps the verified gene HVG1; protein product detected in mitochondria Unknown Unknown Unknown
YNL085W YNL085W MKT1 hom Verified 0.364373604291806 0.357789521702653 no 1662 0.356216611178319 1179 NA FT RESPONSE TO DNA DAMAGE|TRANSLATION Protein that forms a complex with Pbp1p; complex may mediate posttranscriptional regulation of HO; involved in propagation of M2 dsRNA satellite of L-A virus; allelic variation affects mitochondrial genome stability, drug resistance, and more; forms cytoplasmic foci upon DNA replication stress positive regulation of translation|interspecies interaction between organisms|response to DNA damage stimulus nuclease activity polysome|cytoplasm
YDL048C YDL048C STP4 hom Verified 0.363569128147207 0.358089891742051 no 1663 0.359969200537979 1208 NA FT NUCLEUS|MITOCHONDRION Protein containing a Kruppel-type zinc-finger domain; has similarity to Stp1p, Stp2p, and Stp3p; predicted to be a transcription factor; relative distribution to the nucleus increases upon DNA replication stress biological_process sequence-specific DNA binding mitochondrion|nucleus|cytoplasm
YOR101W YOR101W RAS1 hom Verified 0.36318779404141 0.358232302482054 no 1664 0.335749380919819 1131 NA FT SIGNALING|NUCLEOTIDE METABOLISM PLASMA MEMBRANE GTPase involved in G-protein signaling in adenylate cyclase activation; plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes; relative distribution to the nucleus increases upon DNA replication stress adenylate cyclase-activating G-protein coupled receptor signaling pathway|replicative cell aging|Ras protein signal transduction GTPase activity plasma membrane
YGL078C YGL078C DBP3 hom Verified 0.362410116899403 0.35852279021771 no 1665 0.362727937266404 1226 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS RNA-Dependent ATPase, member of DExD/H-box family; involved in cleavage of site A3 within the ITS1 spacer during rRNA processing; not essential for growth, but deletion causes severe slow-growth phenotype endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) RNA-dependent ATPase activity nucleolus|preribosome, large subunit precursor
YIR020W-A_d YIR020W-A YIR020W-A hom Dubious 0.360459108675219 0.359251915370944 no 1666 0.371079133467465 1276 NA Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data Unknown Unknown Unknown
YPR100W YPR100W MRPL51 hom Verified 0.360298394705158 0.359311999831304 no 1667 0.381795262183757 1267 NA FT TRANSLATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation|aerobic respiration structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YPL193W YPL193W RSA1 hom Verified 0.359936532857824 0.359447298090653 no 1668 0.384916883519847 1292 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS NUCLEUS Protein involved in the assembly of 60S ribosomal subunits; functionally interacts with Dbp6p; functions in a late nucleoplasmic step of the assembly ribosomal large subunit assembly molecular_function nucleoplasm
YLR092W YLR092W SUL2 hom Verified 0.359488573648385 0.359614812115291 no 1669 0.360462592019309 1185 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates sulfate transport sulfate transmembrane transporter activity integral to membrane|plasma membrane
YER067W YER067W RGI1 hom Verified 0.359214499956386 0.359717315079748 no 1670 0.336479550193057 1119 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS|PLASMA MEMBRANE Protein of unknown function; involved in energy metabolism under respiratory conditions; protein abundance is increased upon intracellular iron depletion; protein abundance increases in response to DNA replication stress energy reserve metabolic process molecular_function cell periphery|nucleus|cytoplasm
YDR375C YDR375C BCS1 hom Verified 0.358845122168795 0.359855477533533 no 1671 0.378252272028781 1259 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases protein insertion into mitochondrial membrane from inner side|chaperone-mediated protein complex assembly|mitochondrial respiratory chain complex III assembly protein transmembrane transporter activity|ATPase activity mitochondrion|mitochondrial inner membrane
YMR156C YMR156C TPP1 hom Verified 0.358351070381352 0.360040301807863 no 1672 0.359923076568341 1187 NA FT RESPONSE TO DNA DAMAGE NUCLEUS DNA 3'-phosphatase; functions in repair of endogenous damage of double-stranded DNA, activity is specific for removal of 3' phosphates at strand breaks; similar to the l-2-haloacid dehalogenase superfamily; homolog of human polynucleotide kinase/3′-phosphatase DNA repair polynucleotide 3'-phosphatase activity cellular_component
YML042W YML042W CAT2 hom Verified 0.358167293632331 0.360109060856555 no 1673 0.351575012379931 1159 NA FT KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes carnitine metabolic process carnitine O-acetyltransferase activity mitochondrion|peroxisomal matrix|peroxisome
YBR130C YBR130C SHE3 hom Verified 0.358132518887616 0.36012207214322 no 1674 0.364152508597575 1220 NA FT RNA LOCALIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH|CYTOSKELETON Protein that acts as an adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritance mating type switching|endoplasmic reticulum inheritance|intracellular mRNA localization mRNA binding actin cap|cytoplasm|cellular bud tip
YOR006C YOR006C TSR3 hom Verified 0.358008714909887 0.36016839584154 no 1675 0.384104622822487 1285 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Protein required for 20S pre-rRNA processing; involved in processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress maturation of SSU-rRNA molecular_function nucleus|cytoplasm
YJL207C YJL207C LAA1 hom Verified 0.357151098323693 0.360489346331913 no 1676 0.36355765696067 1199 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene protein localization|retrograde transport, endosome to Golgi molecular_function AP-1 adaptor complex|ribosome|clathrin-coated vesicle
YDL069C YDL069C CBS1 hom Verified 0.357046887778931 0.36052835231093 no 1677 0.36642208367327 1224 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial translational activator of the COB mRNA; membrane protein that interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader mitochondrial respiratory chain complex III biogenesis|positive regulation of mitochondrial translation translation regulator activity extrinsic to mitochondrial inner membrane|mitochondrion|mitochondrial ribosome
YOR360C YOR360C PDE2 hom Verified 0.356028348040938 0.360909667821312 no 1678 0.384697524833862 1252 NA FT SIGNALING NUCLEUS High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon cAMP-mediated signaling 3',5'-cyclic-AMP phosphodiesterase activity nucleus|cytoplasm
YMR232W YMR232W FUS2 hom Verified 0.355538978549728 0.361092924586967 no 1679 0.306683726287284 1020 NA FT SIGNALING NUCLEUS|MITOCHONDRION|SITE OF POLARIZED GROWTH Cytoplasmic protein localized to the shmoo tip; required for the alignment of parental nuclei before nuclear fusion during mating karyogamy involved in conjugation with cellular fusion|regulation of termination of mating projection growth|cytogamy molecular_function mitochondrion|nucleus|mating projection tip|cytoplasm
YBR056W-A_p YBR056W-A YBR056W-A hom Uncharacterized 0.35539704224033 0.36114608219007 no 1680 0.391386653806072 1291 NA Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the dubious ORF YBR056C-B biological_process molecular_function cellular_component
YOR293C-A_p YOR293C-A YOR293C-A hom Uncharacterized 0.355109778175552 0.361253675756041 no 1681 0.348604424305063 1142 NA Putative protein of unknown function; identified by expression profiling and mass spectrometry biological_process molecular_function cellular_component
YGR174C YGR174C CBP4 hom Verified 0.353829184294864 0.36173345031229 no 1682 0.359163501199463 1192 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial protein required for assembly of cytochrome bc1 complex; interacts with the Cbp3p-Cbp6p complex and newly synthesized cytochrome b (Cobp) to promote assembly of Cobp into the cytochrome bc1 complex mitochondrial respiratory chain complex III assembly molecular_function mitochondrion|integral to mitochondrial membrane
YIL071C YIL071C PCI8 hom Verified 0.353175117757309 0.36197858030479 no 1683 0.367355006048484 1245 NA FT NUCLEUS Possible shared subunit of Cop9 signalosome (CSN) and eIF3, binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain cullin deneddylation molecular_function signalosome
YDL019C YDL019C OSH2 hom Verified 0.352878183854869 0.362089883405711 no 1684 0.383830028027655 1257 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability endocytosis|maintenance of cell polarity|sterol transport|exocytosis lipid binding|oxysterol binding|sterol transporter activity|1-phosphatidylinositol binding endoplasmic reticulum|plasma membrane|cortical endoplasmic reticulum|cellular bud neck
YIL099W YIL099W SGA1 hom Verified 0.352407974374871 0.362266161210274 no 1685 0.361022903115017 1202 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation ascospore formation|glycogen catabolic process glucan 1,4-alpha-glucosidase activity fungal-type vacuole
YOL138C YOL138C RTC1 hom Verified 0.352077684036164 0.362390001907436 no 1686 0.364276890567246 1227 NA Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; null mutation suppresses cdc13-1 temperature sensitivity; has N-terminal WD-40 repeats and a C-terminal RING motif biological_process molecular_function ribosome|fungal-type vacuole|Seh1-associated complex|extrinsic to fungal-type vacuolar membrane
YPL030W YPL030W TRM44 hom Verified 0.350857920051804 0.362847470973877 no 1687 0.353555923082884 1190 NA FT RNA PROCESSING tRNA(Ser) Um(44) 2'-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS(CGA) and tS(UGA); conserved among metazoans and fungi but there does not appear to be a homolog in plants; TRM44 is a non-essential gene tRNA methylation tRNA (uracil) methyltransferase activity cytoplasm
YHR181W YHR181W SVP26 hom Verified 0.349477301395856 0.363365504363244 no 1688 0.348785014133525 1181 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment protein retention in Golgi apparatus|fungal-type cell wall organization|protein glycosylation|ER to Golgi vesicle-mediated transport COPII adaptor activity integral to endoplasmic reticulum membrane|integral to membrane|endoplasmic reticulum|integral to Golgi membrane|ER to Golgi transport vesicle
YBR261C YBR261C TAE1 hom Verified 0.349462796622548 0.363370948148283 no 1689 0.343915353146946 1170 NA FT TRANSLATION AdoMet-dependent proline methyltransferase; catalyzes the dimethylation of ribosomal proteins Rpl12 and Rps25 at N-terminal proline residues; has a role in protein synthesis; fusion protein localizes to the cytoplasm cytoplasmic translation|N-terminal peptidyl-proline dimethylation N-terminal protein N-methyltransferase activity cytosol|cytoplasm
YHR013C YHR013C ARD1 hom Verified 0.348076530408925 0.363891354781009 no 1690 0.365564033176814 1238 NA FT CHROMATIN ORGANIZATION RIBOSOME Subunit of protein N-terminal acetyltransferase NatA; NatA is comprised of Nat1p, Ard1p, and Nat5p; acetylates many proteins and thus affects telomeric silencing, cell cycle, heat-shock resistance, mating, and sporulation; human Ard1p levels are elevated in cancer cells; protein abundance increases in response to DNA replication stress histone acetylation|N-terminal protein amino acid acetylation peptide alpha-N-acetyltransferase activity cytosolic ribosome|NatA complex
YGR222W YGR222W PET54 hom Verified 0.347003490379255 0.364294348285305 no 1691 0.366607949683574 1218 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial inner membrane protein; binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing Group I intron splicing|positive regulation of mitochondrial translation|mitochondrial respiratory chain complex IV biogenesis translation regulator activity|RNA binding mitochondrion|extrinsic to mitochondrial inner membrane|mitochondrial inner membrane|mitochondrial matrix
YLL033W YLL033W IRC19 hom Verified 0.34551325461929 0.364854273690407 no 1692 0.341094271956972 1166 NA Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci mitotic recombination|ascospore formation molecular_function cellular_component
YPR058W YPR058W YMC1 hom Verified 0.344513228424321 0.365230174699591 no 1693 0.361621882177464 1161 NA FT MITOCHONDRION Putative mitochondrial inner membrane transporter; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; YMC1 has a paralog, YMC2, that arose from the whole genome duplication mitochondrial transport organic acid transmembrane transporter activity mitochondrion|integral to membrane
YLR143W YLR143W DPH6 hom Verified 0.342192418861574 0.366103045056051 no 1694 0.383925743823433 1278 NA Diphthamide synthetase; catalyzes the last amidation step of diphthamide biosynthesis using ammonium and ATP; evolutionarily conserved in eukaryotes; dph6 mutants exhibit diphthine accumulation and resistance to sordarin, which is indicative of defects in diphthamide formation on EF2; green fluorescent protein (GFP)-tagged protein localizes to the cytoplasm; DPH6/YLR143W is not an essential gene biological_process molecular_function cytoplasm
YOR325W_d YOR325W YOR325W hom Dubious 0.341363613465895 0.366414931985673 no 1695 0.369516879335463 1273 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF FRT1 Unknown Unknown Unknown
YNL067W-B_p YNL067W-B YNL067W-B hom Uncharacterized 0.341035084256408 0.366538584919027 no 1696 0.378942016728496 1275 NA Putative protein of unknown function biological_process molecular_function cellular_component
YIR030C YIR030C DCG1 hom Verified 0.340765789786781 0.366639953214429 no 1697 0.361733788252028 1228 NA Protein of unknown function, expression is sensitive to nitrogen catabolite repression and regulated by Dal80p; contains transmembrane domain nitrogen compound metabolic process molecular_function cellular_component
YER187W_p YER187W YER187W hom Uncharacterized 0.340662931506606 0.366678673763729 no 1698 0.352711631198855 1186 NA Putative protein of unknown function; induced in respiratory-deficient cells biological_process molecular_function cellular_component
YLR032W YLR032W RAD5 hom Verified 0.340656746368441 0.366681002175166 no 1699 0.379431985171757 1273 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME DNA helicase; proposed to promote replication fork regression during postreplication repair by template switching; RING finger containing ubiquitin ligase; stimulates the synthesis of free and PCNA-bound polyubiquitin chains by Ubc13p-Mms2p; required for error-prone translesion synthesis; forms nuclear foci upon DNA replication stress double-strand break repair|postreplication repair|protein polyubiquitination|free ubiquitin chain polymerization four-way junction helicase activity|four-way junction DNA binding|DNA-dependent ATPase activity|Y-form DNA binding nuclear chromatin
YBR188C YBR188C NTC20 hom Verified 0.340489493950967 0.366743966644837 no 1700 0.365220630711661 1188 NA FT RNA PROCESSING NUCLEUS Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs mRNA splicing, via spliceosome first spliceosomal transesterification activity Prp19 complex|U2-type catalytic step 1 spliceosome
YDL118W_d YDL118W YDL118W hom Dubious 0.339119564089382 0.36725983038453 no 1701 0.388443659127305 1289 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS Dubious open reading frame, unlikely to encode a protein; overlaps almost completely with YDL119C; mutations that would affect both YDL118W and YDL119C confer defective telomere maintenance and are synthetically sick or lethal with alpha-synuclein biological_process molecular_function cellular_component
YOR309C_d YOR309C YOR309C hom Dubious 0.339118545981299 0.367260213854749 no 1702 0.382433854113834 1260 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58 Unknown Unknown Unknown
YBR145W YBR145W ADH5 hom Verified 0.338702031437287 0.367417105082615 no 1703 0.367811251606389 1219 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM NUCLEUS Alcohol dehydrogenase isoenzyme V; involved in ethanol production; ADH5 has a paralog, ADH1, that arose from the whole genome duplication NADH oxidation|ethanol biosynthetic process involved in glucose fermentation to ethanol|amino acid catabolic process to alcohol via Ehrlich pathway alcohol dehydrogenase (NAD) activity nucleus|cytoplasm
YDR338C_p YDR338C YDR338C hom Uncharacterized 0.338648190015814 0.367437387495255 no 1704 0.388415294078247 1306 NA Putative protein of unknown function, member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily transmembrane transport antiporter activity integral to membrane
YGR282C YGR282C BGL2 hom Verified 0.338528137394723 0.367482613427734 no 1705 0.36996514113036 1243 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM Endo-beta-1,3-glucanase, major protein of the cell wall, involved in cell wall maintenance fungal-type cell wall organization 1,3-beta-glucanosyltransferase activity|glucan endo-1,3-beta-D-glucosidase activity fungal-type cell wall
YPL087W YPL087W YDC1 hom Verified 0.337943475271153 0.367702892188282 no 1706 0.345876509696341 1167 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Alkaline dihydroceramidase, involved in sphingolipid metabolism; preferentially hydrolyzes dihydroceramide to a free fatty acid and dihydrosphingosine; has a minor reverse activity; YDC1 has a paralog, YPC1, that arose from the whole genome duplication ceramide catabolic process|ceramide biosynthetic process dihydroceramidase activity integral to membrane|endoplasmic reticulum
YDR074W YDR074W TPS2 hom Verified 0.336571117056803 0.368220116172347 no 1707 0.462631612892251 1521 NA FT CARBOHYDRATE METABOLISM MITOCHONDRION Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex; involved in synthesis of the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; protein abundance increases in response to DNA replication stress trehalose biosynthetic process|response to stress trehalose-phosphatase activity mitochondrion|alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
YPR039W_d YPR039W YPR039W hom Dubious 0.336223641293507 0.368351113219304 no 1708 0.382294102789605 1280 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified non essential genes ERV2/YPR037C and TIP41/YPR040W Unknown Unknown Unknown
YMR038C YMR038C CCS1 hom Verified 0.335624720096307 0.368576940160304 no 1709 0.41954337553545 1388 NA FF|FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS NUCLEUS|MITOCHONDRION Copper chaperone for superoxide dismutase Sod1p; involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation; protein abundance increases in response to DNA replication stress intracellular copper ion transport superoxide dismutase copper chaperone activity cytosol|mitochondrial inner membrane|nucleus
YAL051W YAL051W OAF1 hom Verified 0.33435659849782 0.369055242988966 no 1710 0.365176448489821 1188 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GENE SILENCING NUCLEUS Oleate-activated transcription factor; acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis; OAF1 has a paralog, PIP2, that arose from the whole genome duplication cellular response to oleic acid|positive regulation of fatty acid beta-oxidation|positive regulation of chromatin silencing at telomere|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YIL120W YIL120W QDR1 hom Verified 0.334232023280345 0.369102240507961 no 1711 0.351424910271665 1191 NA FT PLASMA MEMBRANE Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for resistance to quinidine, ketoconazole, fluconazole, and barban; QDR1 has a paralog, AQR1, that arose from the whole genome duplication drug transmembrane transport drug transmembrane transporter activity integral to membrane|plasma membrane
YGR039W_d YGR039W YGR039W hom Dubious 0.333984860870982 0.369195491331251 no 1712 0.384930130852222 1279 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the Autonomously Replicating Sequence ARS722 Unknown Unknown Unknown
YGR242W_d YGR242W YGR242W hom Dubious 0.333317880559449 0.369447171814468 no 1713 0.371135054561993 1213 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C Unknown Unknown Unknown
YCL056C YCL056C PEX34 hom Verified 0.333110372558332 0.369525484964778 no 1714 0.359697335478236 1181 NA FT PEROXISOME ORGANIZATION Peroxisomal integral membrane protein that regulates peroxisome populations; interacts with Pex11p, Pex25p, and Pex27p to control both constitutive peroxisome division and peroxisome morphology and abundance during peroxisome proliferation peroxisome organization molecular_function integral to peroxisomal membrane|cytoplasm
YLR384C YLR384C IKI3 hom Verified 0.333009001398574 0.369563744228472 no 1715 0.352350600342193 1184 NA FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD) regulation of transcription from RNA polymerase II promoter|tRNA wobble uridine modification molecular_function Elongator holoenzyme complex|nucleus|cytoplasm
YGR237C_p YGR237C YGR237C hom Uncharacterized 0.332397057535369 0.369794730054979 no 1716 0.35994816535266 1171 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm biological_process molecular_function cytoplasm
YGL082W_p YGL082W YGL082W hom Uncharacterized 0.331796594265871 0.370021428064142 no 1717 0.34129379155021 1134 NA FT NUCLEUS Putative protein of unknown function; predicted prenylation/proteolysis target of Afc1p and Rce1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YGL082W is not an essential gene biological_process molecular_function nucleus|plasma membrane|cytoplasm
YPL145C YPL145C KES1 hom Verified 0.331716380295687 0.370051715348753 no 1718 0.369813051782969 1218 NA FT VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|GOLGI APPARATUS One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication post-Golgi vesicle-mediated transport|positive regulation of phosphatase activity|maintenance of cell polarity|endocytosis|exocytosis|sterol transport phosphatidic acid binding|lipid binding|phosphatidylinositol-4,5-bisphosphate binding|oxysterol binding|sterol transporter activity|phosphatidylinositol-4-phosphate binding Golgi membrane|extrinsic to membrane|cytoplasm
YGL256W YGL256W ADH4 hom Verified 0.331275248681827 0.370218292737234 no 1719 0.361473402937624 1231 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Alcohol dehydrogenase isoenzyme type IV, dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency fermentation|amino acid catabolic process to alcohol via Ehrlich pathway alcohol dehydrogenase (NAD) activity mitochondrion
YCR014C YCR014C POL4 hom Verified 0.329679186008302 0.370821191216434 no 1720 0.36899947988315 1231 NA FT RESPONSE TO DNA DAMAGE NUCLEUS DNA polymerase IV, undergoes pair-wise interactions with Dnl4p-Lif1p and Rad27p to mediate repair of DNA double-strand breaks by non-homologous end joining (NHEJ); homologous to mammalian DNA polymerase beta double-strand break repair|base-excision repair, gap-filling|double-strand break repair via nonhomologous end joining DNA-directed DNA polymerase activity nucleus
YKR091W YKR091W SRL3 hom Verified 0.329418834981918 0.370919566639871 no 1721 0.378018102571705 1262 NA Cytoplasmic protein that, when overexpressed, suppresses the lethality of a rad53 null mutation; potential Cdc28p substrate nucleobase-containing compound metabolic process molecular_function cytoplasm
YHR182W YHR182W YHR182W hom Verified 0.329307352240619 0.370961693739699 no 1722 0.38900815389817 1300 NA FT SIGNALING Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm; relocalizes from bud neck to cytoplasm upon DNA replication stress biological_process molecular_function cytoplasm
YLR308W YLR308W CDA2 hom Verified 0.328550427545332 0.371247761328926 no 1723 0.369674460210664 1243 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM Chitin deacetylase, together with Cda1p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall ascospore wall assembly chitin deacetylase activity chitosan layer of spore wall
YPL115C YPL115C BEM3 hom Verified 0.328147437019078 0.371400094190252 no 1724 0.385794516731017 1286 NA FT SIGNALING SITE OF POLARIZED GROWTH Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly negative regulation of Rho protein signal transduction|establishment of cell polarity Rho GTPase activator activity|phosphatidylinositol-3-phosphate binding cell cortex|incipient cellular bud site|mating projection tip|cytoplasm|cellular bud tip
YNR056C YNR056C BIO5 hom Verified 0.327612604544757 0.371602295213652 no 1725 0.361788959023413 1191 NA FT KETONE METABOLISM|COFACTOR METABOLISM PLASMA MEMBRANE Putative transmembrane protein involved in the biotin biosynthesis pathway; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis biotin biosynthetic process|vitamin transport transmembrane transporter activity integral to membrane|plasma membrane
YOR180C YOR180C DCI1 hom Verified 0.326763352322222 0.371923439874171 no 1726 0.401469456675382 1321 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS Peroxisomal protein; identification as a delta(3,5)-delta(2,4)-dienoyl-CoA isomerase involved in fatty acid metabolism is disputed fatty acid beta-oxidation dodecenoyl-CoA delta-isomerase activity peroxisomal matrix
YDL067C YDL067C COX9 hom Verified 0.32665513884079 0.371964367200149 no 1727 0.378918504360576 1248 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain mitochondrial electron transport, cytochrome c to oxygen cytochrome-c oxidase activity mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YOR038C YOR038C HIR2 hom Verified 0.326191234811572 0.372139836326216 no 1728 0.367579217088576 1237 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p DNA replication-independent nucleosome assembly|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter nucleosome binding|transcription corepressor activity|DNA binding HIR complex|nucleus
YBR262C YBR262C AIM5 hom Verified 0.325432566429879 0.372426855641811 no 1729 0.333173773243665 1097 NA FT MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture cristae formation molecular_function mitochondrion|mitochondrial crista junction|integral to mitochondrial inner membrane
YJL056C YJL056C ZAP1 hom Verified 0.32133239184824 0.373979255888401 no 1730 0.463060821178677 1518 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS NUCLEUS Zinc-regulated transcription factor; binds to zinc-responsive promoters to induce transcription of certain genes in presence of zinc, represses other genes in low zinc; regulates its own transcription; contains seven zinc-finger domains regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation|positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding RNA polymerase II transcription factor activity|RNA polymerase II regulatory region sequence-specific DNA binding|zinc ion binding nucleus
YPR047W YPR047W MSF1 hom Verified 0.321192318916213 0.374032326320856 no 1731 0.404162116896066 1355 NA FT KETONE METABOLISM|RNA PROCESSING|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial phenylalanyl-tRNA synthetase, active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase phenylalanyl-tRNA aminoacylation|mitochondrial phenylalanyl-tRNA aminoacylation phenylalanine-tRNA ligase activity mitochondrion
YLR239C YLR239C LIP2 hom Verified 0.320798258854223 0.374181639475958 no 1732 0.443166930871473 1455 NA FF|FT KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM MITOCHONDRION Lipoyl ligase, involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups protein lipoylation ligase activity mitochondrion
YLL016W YLL016W SDC25 hom pseudogene 0.320562798849608 0.374270866551516 no 1733 0.375770365327129 1269 NA FT SIGNALING Non-essential Ras guanine nucleotide exchange factor (GEF); localized to the membrane; expressed in poor nutrient conditions and on nonfermentable carbon sources; contains a stop codon in S288C, full-length gene includes YLL017W; SDC25 has a paralog, CDC25, that arose from the whole genome duplication Ras protein signal transduction Ras guanyl-nucleotide exchange factor activity cellular_component
YBR150C YBR150C TBS1 hom Verified 0.319521187275589 0.374665663812862 no 1734 0.36249539567696 1216 NA FT TRANSCRIPTION FROM RNA POL II ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; TBS1 has a paralog, HAL9, that arose from the whole genome duplication biological_process sequence-specific DNA binding mitochondrion|nucleus|cytoplasm
YNL197C YNL197C WHI3 hom Verified 0.319487259431471 0.37467852554022 no 1735 0.374797829176586 1245 NA FT PROTEIN LOCALIZATION|CELL CYCLE RNA binding protein that sequesters CLN3 mRNA in cytoplasmic foci;; Tpk1 (PKA) mediated phosphorylation of Whi3 affects G1/S transition by modulating Cln3 transcription; cytoplasmic retention factor for Cdc28p and associated cyclins; regulates cell fate and dose-dependently regulates the critical cell size required for passage through Start; WHI3 has a paralog, WHI4, that arose from the whole genome duplication pseudohyphal growth|invasive growth in response to glucose limitation|regulation of cell size|cytoplasmic sequestering of protein RNA binding cytoplasm
YDL133W YDL133W SRF1 hom Verified 0.318552080821082 0.375033097812882 no 1736 0.429122465114125 1408 NA Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients positive regulation of catalytic activity molecular_function integral to membrane
YLL027W YLL027W ISA1 hom Verified 0.318525479035643 0.375043185406608 no 1737 0.388037616337471 1289 NA FT KETONE METABOLISM|COFACTOR METABOLISM MITOCHONDRION Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa2p and possibly Iba57p; isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources; functional ortholog of bacterial A-type ISC proteins biotin biosynthetic process|iron-sulfur cluster assembly iron-sulfur cluster binding|iron ion binding mitochondrial matrix
YNL056W YNL056W OCA2 hom Verified 0.318189985916237 0.375170414212591 no 1738 0.376685901263543 1222 NA Putative protein with similarity to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene biological_process molecular_function cytoplasm
YNR063W_p YNR063W YNR063W hom Uncharacterized 0.318097150393605 0.375205622558529 no 1739 0.362502565232501 1203 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Putative zinc-cluster protein of unknown function biological_process sequence-specific DNA binding cellular_component
YMR201C YMR201C RAD14 hom Verified 0.317977538848896 0.37525098738033 no 1740 0.380253141342741 1259 NA FT RESPONSE TO DNA DAMAGE NUCLEUS Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein nucleotide-excision repair, DNA damage recognition damaged DNA binding|zinc ion binding nucleotide-excision repair factor 1 complex|nucleus
YDR479C YDR479C PEX29 hom Verified 0.31743455290054 0.375456946218015 no 1741 0.385430245505811 1305 NA FT PEROXISOME ORGANIZATION Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress peroxisome organization molecular_function integral to membrane|peroxisomal membrane
YHR105W YHR105W YPT35 hom Verified 0.316704465028009 0.375733930236712 no 1742 0.356712369400512 1166 NA Endosomal protein of unknown function that contains a phox (PX) homology domain and binds to both phosphatidylinositol-3-phosphate (PtdIns(3)P) and proteins involved in ER-Golgi or vesicular transport biological_process phosphatidylinositol-3-phosphate binding endosome
YML110C YML110C COQ5 hom Verified 0.316212604210276 0.375920570724521 no 1743 0.381491986949358 1246 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes ubiquinone biosynthetic process|aerobic respiration 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity mitochondrion|mitochondrial matrix
YLR203C YLR203C MSS51 hom Verified 0.315802752238505 0.376076114481001 no 1744 0.366399368817995 1183 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Specific translational activator for the mitochondrial COX1 mRNA; loosely associated with the matrix face of the mitochondrial inner membrane; influences both COX1 mRNA translation and Cox1p assembly into cytochrome c oxidase; binds to heme B, which may be a mechanism for sensing oxygen levels in order to regulate cytochrome c oxidase biogenesis mitochondrial respiratory chain complex IV biogenesis|positive regulation of mitochondrial translation translation regulator activity extrinsic to mitochondrial inner membrane|mitochondrion
YGR275W YGR275W RTT102 hom Verified 0.315801009369566 0.376076775963749 no 1745 0.387965587422366 1253 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|CHROMOSOME SEGREGATION NUCLEUS RSC COMPLEX Component of both the SWI/SNF and RSC chromatin remodeling complexes; suggested role in chromosome maintenance; possible weak regulator of Ty1 transposition; protein abundance increases in response to DNA replication stress chromosome segregation|nucleosome disassembly|chromatin remodeling|transcription elongation from RNA polymerase II promoter molecular_function RSC complex|SWI/SNF complex|nucleus
YHR003C YHR003C YHR003C hom Verified 0.315045838286997 0.376363425344844 no 1746 0.349084791536153 1171 NA FT MITOCHONDRION Protein of unknown function, localized to the mitochondrial outer membrane biological_process molecular_function mitochondrial outer membrane|mitochondrion
YDL160C YDL160C DHH1 hom Verified 0.314640256524634 0.376517405060166 no 1747 0.394454978483375 1326 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION|RNA LOCALIZATION Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping; coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, may have a role in mRNA export and translation; C-terminus of Dhh1p interacts with Ngr1p and promotes POR1, but not EDC1 mRNA decay; forms cytoplasmic foci upon DNA replication stress deadenylation-dependent decapping of nuclear-transcribed mRNA|cell morphogenesis involved in conjugation with cellular fusion|stress granule assembly|cytoplasmic mRNA processing body assembly protein binding|RNA helicase activity cytoplasmic mRNA processing body|cytoplasmic stress granule|cytoplasm
YBR260C YBR260C RGD1 hom Verified 0.312109777819365 0.377478547915667 no 1748 0.366526475139293 1197 NA FT SIGNALING SITE OF POLARIZED GROWTH|CYTOSKELETON GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization response to acid|osmosensory signaling pathway Rho GTPase activator activity|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding cellular bud|mating projection tip|actin cortical patch
YDR516C YDR516C EMI2 hom Verified 0.311653178083012 0.377652057629875 no 1749 0.361626997514536 1163 NA FT TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression regulated by glucose-repression transcription factors Mig1/2p; EMI2 has a paralog, GLK1, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress ascospore formation|positive regulation of transcription from RNA polymerase II promoter molecular_function cytoplasm
YGR148C YGR148C RPL24B hom Verified 0.311512085662605 0.377705678305735 no 1750 0.373732033746658 1215 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L24B; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24B has a paralog, RPL24A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YOL084W YOL084W PHM7 hom Verified 0.311209751283946 0.377820585209903 no 1751 0.347454324100185 1164 NA FT PLASMA MEMBRANE Protein of unknown function; expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole; protein abundance increases in response to DNA replication stress biological_process molecular_function integral to membrane|fungal-type vacuole
YDR524C-B_p YDR524C-B YDR524C-B hom Uncharacterized 0.310721209452133 0.378006286013144 no 1752 0.393022274844255 1339 NA FT PLASMA MEMBRANE Putative protein of unknown function; YDR524C-B has a paralog, YCL048W-A, that arose from the whole genome duplication biological_process molecular_function cellular_component
YML057W YML057W CMP2 hom Verified 0.310494150203472 0.378092603645356 no 1753 0.351542945242319 1153 NA FT SIGNALING|ION HOMEOSTASIS|ION HOMEOSTASIS Calcineurin A; one isoform (the other is CNA1) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1 adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|cellular ion homeostasis calcium-dependent protein serine/threonine phosphatase activity calcineurin complex|cytoplasm
YOL051W YOL051W GAL11 hom Verified 0.310047563820524 0.378262393293221 no 1754 0.424666429135442 1427 NA FF|FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors; forms part of the tail domain of mediator negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly|TFIIE-class binding transcription factor activity|RNA polymerase II activating transcription factor binding|TFIIE-class transcription factor binding|TFIIH-class transcription factor binding|RNA polymerase II transcription factor recruiting transcription factor activity core mediator complex
YKL117W YKL117W SBA1 hom Verified 0.309490373550556 0.378474266884123 no 1755 0.366569245812425 1174 NA FT NUCLEUS Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins, and like p23 can regulate telomerase activity; protein abundance increases in response to DNA replication stress protein folding|positive regulation of telomere maintenance via telomerase|regulation of telomerase activity chaperone binding nucleus|cytoplasm
YDL114W_p YDL114W YDL114W hom Uncharacterized 0.30910404041567 0.378621192893289 no 1756 0.383590292314211 1279 NA FT OXIDATION-REDUCTION PROCESS Putative short-chain dehydrogenase/reductase; YDL114W is not an essential gene biological_process molecular_function integral to membrane
YFR054C_d YFR054C YFR054C hom Dubious 0.309056206499188 0.378639385788467 no 1757 0.352741422769418 1188 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YEL041W YEL041W YEF1 hom Verified 0.308263089354613 0.378941074879739 no 1758 0.396697388614346 1288 NA FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM ATP-NADH kinase; phosphorylates both NAD and NADH; homooctameric structure consisting of 60-kDa subunits; similar to Pos5p; overexpression complements certain pos5 phenotypes; YEF1 has a paralog, UTR1, that arose from the whole genome duplication NADP biosynthetic process NAD+ kinase activity|NADH kinase activity cellular_component
YFL025C YFL025C BST1 hom Verified 0.30760828747091 0.379190206656092 no 1759 0.440916193521728 1462 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|PROTEOLYSIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules protein retention in ER lumen|vesicle organization|ER-associated protein catabolic process|ER to Golgi vesicle-mediated transport|GPI anchor metabolic process phosphatidylinositol deacylase activity integral to membrane|endoplasmic reticulum
YEL007W YEL007W MIT1 hom Verified 0.307444762511369 0.379252430658769 no 1760 0.361337596019164 1217 NA FT NUCLEUS Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1 biological_process molecular_function nucleus|cytoplasm
YOL039W YOL039W RPP2A hom Verified 0.307380544821269 0.379276867427574 no 1761 0.387540311453608 1295 NA FT TRANSLATION RIBOSOME Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm translational elongation|cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YNL321W YNL321W VNX1 hom Verified 0.307065616474713 0.379396714147712 no 1762 0.385448574864086 1262 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Calcium/H+ antiporter localized to the endoplasmic reticulum membrane; member of the calcium exchanger (CAX) family; potential Cdc28p substrate potassium ion transport|sodium ion transport|hydrogen transport potassium:hydrogen antiporter activity|sodium:hydrogen antiporter activity|calcium:hydrogen antiporter activity fungal-type vacuole membrane|integral to membrane|endoplasmic reticulum membrane|fungal-type vacuole
YER097W_d YER097W YER097W hom Dubious 0.305074074874187 0.380154867921792 no 1763 0.420160080966081 1381 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YER011W YER011W TIR1 hom Verified 0.304834160802202 0.380246231214242 no 1764 0.353624778871567 1182 NA Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking response to stress structural constituent of cell wall fungal-type cell wall
YER080W YER080W AIM9 hom Verified 0.304448543115255 0.380393094880326 no 1765 0.391668890187646 1296 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss biological_process molecular_function mitochondrion
YDR466W YDR466W PKH3 hom Verified 0.304014414939348 0.380558454545401 no 1766 0.408983518288641 1373 NA FF|FT SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant MAPK cascade involved in cell wall biogenesis|protein phosphorylation protein kinase activity cellular_component
YCR043C_p YCR043C YCR043C hom Uncharacterized 0.303073480518066 0.380916931873096 no 1767 0.38865479127613 1282 NA FT GOLGI APPARATUS|SITE OF POLARIZED GROWTH Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene biological_process molecular_function Golgi apparatus|mating projection tip
YDR414C YDR414C ERD1 hom Verified 0.303058136282907 0.380922778569991 no 1768 0.39488130481293 1314 NA FT PROTEIN LOCALIZATION|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p) protein retention in ER lumen|protein glycosylation molecular_function integral to membrane|membrane
YIL010W YIL010W DOT5 hom Verified 0.303033471103283 0.380932176933736 no 1769 0.352129411657729 1169 NA FT OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS NUCLEUS|CHROMOSOME Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth cellular response to oxidative stress|cell redox homeostasis thioredoxin peroxidase activity nucleus
YPL004C YPL004C LSP1 hom Verified 0.302335515930833 0.381198153278375 no 1770 0.372187785467188 1213 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION MITOCHONDRION Primary component of eisosomes, which are large immobile patch structures at the cell cortex associated with endocytosis, along with Pil1p and Sur7p; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; member of the BAR domain family negative regulation of protein kinase activity|endocytosis|response to heat lipid binding mitochondrial outer membrane|eisosome|mitochondrion|plasma membrane|cytoplasm
YMR259C YMR259C TRM732 hom Verified 0.30226336735939 0.381225650816435 no 1771 0.38974813126552 1279 NA Interacts with Trm7p for 2'-O-methylation of C32 of substrate tRNAs; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; non-essential gene biological_process molecular_function cytoplasm
YOR220W YOR220W RCN2 hom Verified 0.301379532053624 0.381562550119941 no 1772 0.376653114142113 1275 NA Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; phosphorylated in response to alpha factor; protein abundance increases in response to DNA replication stress biological_process molecular_function cytoplasm
YBR144C_d YBR144C YBR144C hom Dubious 0.30122139020426 0.381622839917394 no 1773 0.366366196283173 1189 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR144C is not an essential gene Unknown Unknown Unknown
YJL127C YJL127C SPT10 hom Verified 0.300175395204326 0.382021685977462 no 1774 0.387175551954882 1270 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING NUCLEUS Putative histone acetylase with a role in transcriptional silencing, sequence-specific activator of histone genes, binds specifically and cooperatively to pairs of UAS elements in core histone promoters, functions at or near the TATA box DNA repair|negative regulation of transcription from RNA polymerase II promoter|chromatin silencing at rDNA|chromatin remodeling|chromatin silencing at telomere|chromatin silencing at silent mating-type cassette histone acetyltransferase activity|sequence-specific DNA binding nucleus
YER166W YER166W DNF1 hom Verified 0.300032806769729 0.382076065770382 no 1775 0.392293253031232 1251 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION|GOLGI APPARATUS|PLASMA MEMBRANE Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase intracellular protein transport|phospholipid translocation|endocytosis|establishment or maintenance of cell polarity phospholipid-translocating ATPase activity|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism mitochondrion|integral to membrane|plasma membrane
YNL100W YNL100W AIM37 hom Verified 0.299746264941721 0.382185352952832 no 1776 0.410491045538719 1357 NA FT MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial inner membrane protein; component of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture cristae formation molecular_function mitochondrion|mitochondrial crista junction|integral to mitochondrial inner membrane
YBR266C_d YBR266C SLM6 hom Dubious 0.298796502324777 0.38254765992015 no 1777 0.39005264200154 1266 NA Protein with a potential role in actin cytoskeleton organization; gene exhibits synthetic genetic interaction with MSS4 encoding phosphatidylinositol 4-phosphate kinase Unknown Unknown Unknown
YNL065W YNL065W AQR1 hom Verified 0.294646847340474 0.384131835496329 no 1778 0.37725702909932 1266 NA FT PLASMA MEMBRANE Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids; AQR1 has a paralog, QDR1, that arose from the whole genome duplication; relocalizes from plasma membrane to cytoplasm upon DNA replication stress monocarboxylic acid transport|drug transmembrane transport|amino acid export monocarboxylic acid transmembrane transporter activity|drug transmembrane transporter activity integral to membrane|plasma membrane
YHR114W YHR114W BZZ1 hom Verified 0.294376840610638 0.384234980905781 no 1779 0.363395033211382 1209 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON SH3 domain protein implicated in the regulation of actin polymerization, able to recruit actin polymerization machinery through its SH3 domains, colocalizes with cortical actin patches and Las17p, interacts with type I myosins response to salt stress|actin filament organization|endocytosis molecular_function mating projection tip|cytoplasm|actin cortical patch
YLR432W YLR432W IMD3 hom Verified 0.2923167415497 0.385022229822321 no 1780 0.412868125896087 1359 NA FT OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed GTP biosynthetic process IMP dehydrogenase activity plasma membrane|cytoplasm
YMR244W_p YMR244W YMR244W hom Uncharacterized 0.291283122969148 0.385417397009979 no 1781 0.33535091795142 1099 NA Putative protein of unknown function biological_process molecular_function cellular_component
YMR245W_d YMR245W YMR245W hom Dubious 0.290906723213778 0.385561329603877 no 1782 0.440965100138492 1469 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YJL044C YJL044C GYP6 hom Verified 0.29031165256789 0.385788912541817 no 1783 0.381488510090299 1279 NA FT PROTEIN LOCALIZATION|SIGNALING|NUCLEOTIDE METABOLISM GTPase-activating protein (GAP) for the yeast Rab family member, Ypt6p; involved in vesicle mediated protein transport intracellular protein transport GTPase activator activity endosome|clathrin-coated vesicle
YEL043W YEL043W YEL043W hom Verified 0.289768521507059 0.385996665668665 no 1784 0.383934869047272 1290 NA FT ENDOPLASMIC RETICULUM Predicted cytoskeleton protein involved in intracellular signalling based on quantitative analysis of protein-protein interaction maps; may interact with ribosomes, based on co-purification studies; contains fibronectin type III domain fold biological_process molecular_function ribosome|endoplasmic reticulum
YDR083W YDR083W RRP8 hom Verified 0.288859279463953 0.386344533113477 no 1785 0.357639388218928 1186 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS|CHROMOSOME Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase; methylates adenine (m1A) of the large subunit (LSU) rRNA at position 645; involved in pre-rRNA cleavage at site A2; mutation is synthetically lethal with a gar1 mutation; deletion disrupts telomere maintenance by influencing the expression of neighboring gene STN1 rRNA processing methyltransferase activity nucleolus
YNL127W YNL127W FAR11 hom Verified 0.288651354780688 0.386424095986363 no 1786 0.436131378442639 1450 NA FT CELL CYCLE|SIGNALING Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far10p; has similarity to the N- and C-termini of N. crassa HAM-2 re-entry into mitotic cell cycle after pheromone arrest molecular_function cellular_component
YML112W YML112W CTK3 hom Verified 0.288307825850692 0.386555558606623 no 1787 0.418293662653059 1368 NA FF|FT RNA PROCESSING|RESPONSE TO DNA DAMAGE|TRANSLATION|PROTEIN PHOSPHORYLATION NUCLEUS Gamma subunit of C-terminal domain kinase I; CTDK-I phosphorylates RNA polymerase II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and also phosphorylates ribosomal protein Rps2p to increase translational fidelity; protein abundance increases in response to DNA replication stress mRNA 3'-end processing|positive regulation of translational fidelity|positive regulation of transcription from RNA polymerase I promoter|positive regulation of DNA-dependent transcription, elongation|protein phosphorylation cyclin-dependent protein kinase activity nucleoplasm|nucleolus|carboxy-terminal domain protein kinase complex
YHR187W YHR187W IKI1 hom Verified 0.287263823568206 0.386955160202087 no 1788 0.37905729060094 1266 NA FT RNA PROCESSING NUCLEUS Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin tRNA modification tRNA binding|ATPase activity Elongator holoenzyme complex|nucleus|cytoplasm
YNL141W YNL141W AAH1 hom Verified 0.28676005345732 0.387148025800586 no 1789 0.392154155430084 1313 NA FT NUCLEOTIDE METABOLISM NUCLEUS Adenine deaminase (adenine aminohydrolase), converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome adenine catabolic process|hypoxanthine salvage|purine-containing compound salvage adenine deaminase activity nucleus|cytoplasm
YNR032C-A YNR032C-A HUB1 hom Verified 0.285932269109856 0.387464998943964 no 1790 0.369362460376079 1234 NA FT RNA PROCESSING Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear cellular protein modification process|cell morphogenesis involved in conjugation with cellular fusion|mRNA splicing, via spliceosome protein tag mating projection
YOR001W YOR001W RRP6 hom Verified 0.285889736782093 0.387481287346537 no 1791 0.318460096285257 1082 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|RNA LOCALIZATION NUCLEUS Nuclear exosome exonuclease component; has 3'-5' exonuclease activity; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10); mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent snRNA catabolic process|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|histone mRNA catabolic process|nuclear polyadenylation-dependent antisense transcript catabolic process|U1 snRNA 3'-end processing|polyadenylation-dependent snoRNA 3'-end processing|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|U5 snRNA 3'-end processing|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear retention of pre-mRNA at the site of transcription|nuclear polyadenylation-dependent mRNA catabolic process|U4 snRNA 3'-end processing|nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription 3'-5'-exoribonuclease activity nucleolus|nucleus|nuclear exosome (RNase complex)
YOL099C_d YOL099C YOL099C hom Dubious 0.283985026552535 0.388210927766717 no 1792 0.351726704635507 1180 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PKH2/YOL100W; may interact with ribosomes Unknown Unknown Unknown
YHR138C YHR138C YHR138C hom Verified 0.282653294190199 0.388721311278622 no 1793 0.393177759905278 1278 NA FT MEMBRANE ORGANIZATION Protein of unknown function; similar to Pbi2p; double null mutant lacking Pbi2p and Yhr138cp exhibits highly fragmented vacuoles; protein abundance increases in response to DNA replication stress vacuole fusion, non-autophagic endopeptidase inhibitor activity cellular_component
YDR538W YDR538W PAD1 hom Verified 0.282520037486526 0.388772392207973 no 1794 0.378470158417434 1258 NA FT KETONE METABOLISM MITOCHONDRION Phenylacrylic acid decarboxylase, confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives; also has mRNA binding activity; homolog of E. coli UbiX cinnamic acid catabolic process|aromatic compound catabolic process mRNA binding|carboxy-lyase activity mitochondrion
YDR296W YDR296W MHR1 hom Verified 0.281735087747864 0.389073323854473 no 1795 0.394985967552538 1315 NA FT MITOCHONDRION ORGANIZATION|RESPONSE TO OXIDATIVE STRESS NUCLEUS|MITOCHONDRION Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress cellular response to oxidative stress|positive regulation of mitochondrial DNA replication|regulation of transcription, DNA-dependent|mitochondrial genome maintenance|DNA recombination single-stranded DNA binding|recombinase activity|DNA binding mitochondrion|nucleus
YKL069W YKL069W YKL069W hom Verified 0.280485746361881 0.389552429761788 no 1796 0.400833297413612 1352 NA FT OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS NUCLEUS Methionine-R-sulfoxide reductase; reduces the R enantiomer of free Met-SO, in contrast to Ycl033Cp which reduces Met-R-SO in a peptide linkage; has a role in protection against oxidative stress; relative distribution to the nucleus increases upon DNA replication stress cellular response to oxidative stress methionine-R-sulfoxide reductase activity nucleus|cytoplasm
YGL077C YGL077C HNM1 hom Verified 0.280401410755522 0.389584777409957 no 1797 0.379572984055874 1266 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Choline/ethanolamine transporter; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol choline transport|ethanolamine transport|glycine betaine transport choline transmembrane transporter activity|ethanolamine transmembrane transporter activity integral to membrane|plasma membrane
YOR104W YOR104W PIN2 hom Verified 0.279986406385955 0.389743967050007 no 1798 0.397080603796179 1302 NA Protein that induces appearance of [PIN+] prion when overproduced; predicted to be palmitoylated biological_process molecular_function cellular_component
YLR315W YLR315W NKP2 hom Verified 0.279812854390997 0.389810544557911 no 1799 0.432145330191624 1448 NA FT CELL CYCLE|CELL DIVISION NUCLEUS|CHROMOSOME|CYTOSKELETON KINETOCHORE Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2 biological_process molecular_function spindle pole body|kinetochore
YER092W YER092W IES5 hom Verified 0.278982029912366 0.39012930776526 no 1800 0.386084973257638 1245 NA FT NUCLEUS Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions biological_process molecular_function nucleus
YBR298C YBR298C MAL31 hom Verified 0.278818707231861 0.390191978628398 no 1801 0.39649282898669 1308 NA FT CARBOHYDRATE METABOLISM Maltose permease, high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL3 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; functional in genomic reference strain S288C alpha-glucoside transport|transmembrane transport alpha-glucoside:hydrogen symporter activity integral to membrane|membrane
YGL191W YGL191W COX13 hom Verified 0.277675759322235 0.390630635171335 no 1802 0.372043506957906 1241 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Subunit VIa of cytochrome c oxidase; present in a subclass of cytochrome c oxidase complexes that may have a role in mimimizing generation of reactive oxygen species; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; required for assembly of Rcf2p into cytochrome c oxidase - cytochrome bc1 supercomplexes mitochondrial respiratory chain supercomplex assembly|aerobic respiration enzyme regulator activity|cytochrome-c oxidase activity mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YAL066W_d YAL066W YAL066W hom Dubious 0.277188887573505 0.390817535944157 no 1803 0.405376957639796 1338 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGL041C_d YGL041C YGL041C hom Dubious 0.275908665450156 0.391309109048899 no 1804 0.397853649730849 1294 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YBR174C_d YBR174C YBR174C hom Dubious 0.275564543737233 0.391441272779345 no 1805 0.393797213545476 1295 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YBR175W; null mutant is viable and sporulation defective Unknown Unknown Unknown
YNL231C YNL231C PDR16 hom Verified 0.275552201525668 0.391446013174414 no 1806 0.4029374139236 1324 NA FF|FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Phosphatidylinositol transfer protein (PITP); controlled by the multiple drug resistance regulator Pdr1p; localizes to lipid particles and microsomes; controls levels of various lipids, may regulate lipid synthesis; homologous to Pdr17p; protein abundance increases in response to DNA replication stress response to drug|sterol biosynthetic process|phospholipid biosynthetic process|phospholipid transport phosphatidylinositol transporter activity|phosphatidylcholine transporter activity cell periphery|lipid particle|plasma membrane|cytoplasm
YNR034W YNR034W SOL1 hom Verified 0.275278273010191 0.391551227752679 no 1807 0.351766635192553 1180 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|RNA LOCALIZATION|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS NUCLEUS Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL1 has a paralog, SOL2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress tRNA export from nucleus molecular_function|6-phosphogluconolactonase activity nucleus|cytoplasm
YNL297C YNL297C MON2 hom Verified 0.275215219511193 0.391575447411164 no 1808 0.435647593910174 1430 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Peripheral membrane protein with a role in endocytosis and vacuole integrity, interacts with Arl1p and localizes to the endosome; member of the Sec7p family of proteins transport|endocytosis|protein targeting to vacuole|Golgi to endosome transport guanyl-nucleotide exchange factor activity cytosol|endosome|trans-Golgi network|extrinsic to membrane
YDR276C YDR276C PMP3 hom Verified 0.274999833341481 0.391658183173629 no 1809 0.407158590975447 1344 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential regulation of membrane potential|cation transport molecular_function plasma membrane
YMR125W YMR125W STO1 hom Verified 0.274305003128222 0.391925119990918 no 1810 0.387998769441825 1260 NA FT RNA PROCESSING|RNA LOCALIZATION NUCLEUS Large subunit of the nuclear mRNA cap-binding protein complex, interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|mRNA splicing, via spliceosome|response to osmotic stress mRNA binding commitment complex|nuclear cap binding complex|polysome
YGR289C YGR289C MAL11 hom Verified 0.27288766437252 0.392469784589067 no 1811 0.403660209292804 1353 NA FT CARBOHYDRATE METABOLISM PLASMA MEMBRANE Inducible high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL1 complex locus; broad substrate specificity that includes maltotriose; required for isomaltose utilization trehalose transport|maltose transport|disaccharide catabolic process trehalose transmembrane transporter activity|alpha-glucoside:hydrogen symporter activity|maltose:hydrogen symporter activity integral to membrane|plasma membrane
YDR497C YDR497C ITR1 hom Verified 0.271666479619797 0.392939238807512 no 1812 0.384502560822586 1254 NA FT PLASMA MEMBRANE Myo-inositol transporter; has strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p; relative distribution to the vacuole increases upon DNA replication stress myo-inositol transport|transmembrane transport myo-inositol transmembrane transporter activity integral to membrane|plasma membrane|membrane
YDL240W YDL240W LRG1 hom Verified 0.271628855683587 0.392953704874342 no 1813 0.399763334982243 1319 NA FT SIGNALING|CELL WALL ORG/BIOGENESIS MITOCHONDRION|SITE OF POLARIZED GROWTH Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity; appears to specifically regulate 1,3-beta-glucan synthesis fungal-type cell wall biogenesis|small GTPase mediated signal transduction Rho GTPase activator activity mitochondrion|cellular bud neck|cytoplasm
YOR365C_p YOR365C YOR365C hom Uncharacterized 0.271444835126183 0.393024461261668 no 1814 0.377370295179449 1250 NA Putative protein of unknown function; not an essential protein; YOR365C has a paralog, FLC2, that arose from the whole genome duplication biological_process molecular_function integral to membrane
YER180C YER180C ISC10 hom Verified 0.270449973536017 0.393407049303976 no 1815 0.386131496891087 1276 NA FT CELL CYCLE Protein required for sporulation, transcript is induced 7.5 hours after induction of meiosis, expected to play significant role in the formation of reproductive cells sporulation resulting in formation of a cellular spore molecular_function cellular_component
YPR062W YPR062W FCY1 hom Verified 0.270062679735787 0.393556016452016 no 1816 0.404798559694461 1309 NA FT NUCLEUS Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU) cytosine metabolic process|pyrimidine-containing compound salvage|cytidine metabolic process cytosine deaminase activity nucleus|cytoplasm
YML026C YML026C RPS18B hom Verified 0.269751040246609 0.393675895540977 no 1817 0.379204712242107 1253 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION MITOCHONDRION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18B has a paralog, RPS18A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress cytoplasmic translation|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA export from nucleus structural constituent of ribosome cytosolic small ribosomal subunit|mitochondrion
YML059C YML059C NTE1 hom Verified 0.26853391765769 0.394144185367128 no 1818 0.395280462415186 1311 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Serine esterase, homolog of human neuropathy target esterase (NTE); Nte1p-mediated phosphatidylcholine turnover influences transcription factor Opi1p localization, affecting transcriptional regulation of phospholipid biosynthesis genes phosphatidylcholine catabolic process|regulation of phospholipid biosynthetic process lysophospholipase activity|carboxylesterase activity integral to membrane|endoplasmic reticulum
YOR172W YOR172W YRM1 hom Verified 0.267700019562412 0.394465117376682 no 1819 0.395281610708653 1294 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrr1p, acting on an overlapping set of target genes regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding|nucleic acid binding transcription factor activity nucleus|cytoplasm
YAL037C-A_p YAL037C-A YAL037C-A hom Uncharacterized 0.267213444452601 0.394652412614499 no 1820 0.39665014814303 1333 NA Putative protein of unknown function biological_process molecular_function cellular_component
YLR020C YLR020C YEH2 hom Verified 0.26669432942672 0.394852260150518 no 1821 0.395957466462921 1320 NA FT LIPID METABOLISM|CELL WALL ORG/BIOGENESIS PLASMA MEMBRANE Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism cell wall mannoprotein biosynthetic process|sterol metabolic process sterol esterase activity integral to membrane|plasma membrane
YDR476C_p YDR476C YDR476C hom Uncharacterized 0.266312759455051 0.394999173600455 no 1822 0.391219409412317 1258 NA FT ENDOPLASMIC RETICULUM Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR476C is not an essential gene biological_process molecular_function endoplasmic reticulum
YOR269W YOR269W PAC1 hom Verified 0.266102206749406 0.395080247757745 no 1823 0.380356014419571 1238 NA FT CELL CYCLE|CELL DIVISION NUCLEUS|CYTOSKELETON Involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; serves at interface between dynein's ATPase site and its microtubule binding stalk, causing individual dynein motors to remain attached to microtubules for long periods; synthetic lethal with bni1; homolog of human LIS1, mutations in which cause the severe brain disorder lissencephaly nuclear migration along microtubule microtubule plus-end binding cytoplasmic microtubule|nucleus|cytoplasm
YMR177W YMR177W MMT1 hom Verified 0.265503189950396 0.395310926394371 no 1824 0.394079678826837 1322 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt2p cellular iron ion homeostasis molecular_function mitochondrion|integral to membrane
YJR052W YJR052W RAD7 hom Verified 0.265119477727507 0.395458711504673 no 1825 0.399099353274401 1316 NA FT RESPONSE TO DNA DAMAGE|PROTEOLYSIS NUCLEUS UBIQUITIN LIGASE COMPLEX Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex nucleotide-excision repair, DNA damage recognition|protein ubiquitination involved in ubiquitin-dependent protein catabolic process damaged DNA binding|ubiquitin-protein ligase activity|DNA-dependent ATPase activity nucleotide-excision repair factor 4 complex|Cul3-RING ubiquitin ligase complex
YKL087C YKL087C CYT2 hom Verified 0.264258163186419 0.395790497812509 no 1826 0.395948983934373 1309 NA FT PROTEIN COMPLEX ORG/BIOGENESIS MITOCHONDRION Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1 cytochrome c-heme linkage holocytochrome-c synthase activity mitochondrion|mitochondrial intermembrane space
YMR302C YMR302C YME2 hom Verified 0.264047351020236 0.395871716117677 no 1827 0.367620728618981 1204 NA FT RNA PROCESSING|MITOCHONDRION ORGANIZATION MITOCHONDRION Integral inner mitochondrial membrane protein with a role in maintaining mitochondrial nucleoid structure and number; mutants exhibit an increased rate of mitochondrial DNA escape; shows some sequence similarity to exonucleases mitochondrial genome maintenance molecular_function mitochondrion|integral to mitochondrial inner membrane
YNL324W_d YNL324W YNL324W hom Dubious 0.26388055503555 0.39593597978348 no 1828 0.407975395847812 1308 NA Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGR161C_p YGR161C RTS3 hom Uncharacterized 0.263820251583084 0.395959214377879 no 1829 0.395288071075982 1302 NA FT NUCLEUS Putative component of the protein phosphatase type 2A complex biological_process molecular_function nucleus|cytoplasm
YLR410W YLR410W VIP1 hom Verified 0.26370343892034 0.396004222717125 no 1830 0.379588141242143 1263 NA FT CYTOSKELETON Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; IP7 production is important for phosphate signaling; involved in cortical actin cytoskeleton function, and invasive pseudohyphal growth analogous to S. pombe asp1 inositol phosphate biosynthetic process inositol hexakisphosphate 1-kinase activity|inositol hexakisphosphate 3-kinase activity|inositol heptakisphosphate kinase activity|inositol hexakisphosphate 4-kinase activity|inositol hexakisphosphate 6-kinase activity cytoplasm
YPR124W YPR124W CTR1 hom Verified 0.263226495998833 0.396188004921705 no 1831 0.468682105632761 1543 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE High-affinity copper transporter of the plasma membrane; mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels; protein increases in abundance and relocalizes from nucleus to plasma membrane upon DNA replication stress copper ion import copper uptake transmembrane transporter activity integral to membrane|plasma membrane
YCR090C_p YCR090C YCR090C hom Uncharacterized 0.262407902968418 0.396503490209854 no 1832 0.351010075988499 1181 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YCR090C is not an essential gene biological_process molecular_function nucleus|cytoplasm
YPL038W YPL038W MET31 hom Verified 0.261804276692877 0.39673617085898 no 1833 0.391704391688919 1319 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; MET31 has a paralog, MET32, that arose from the whole genome duplication regulation of sulfur amino acid metabolic process|regulation of transcription from RNA polymerase II promoter core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity nucleus|cytoplasm
YOL129W YOL129W VPS68 hom Verified 0.261206826387081 0.396966507060264 no 1834 0.402291483748149 1335 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT MITOCHONDRION Vacuolar membrane protein of unknown function involved in vacuolar protein sorting; also detected in the mitochondria late endosome to vacuole transport via multivesicular body sorting pathway|protein targeting to vacuole molecular_function Vps55/Vps68 complex|mitochondrion|fungal-type vacuole membrane|integral to membrane
YGL213C YGL213C SKI8 hom Verified 0.26068872256908 0.397166281759731 no 1835 0.389782691906902 1290 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE NUCLEUS|CHROMOSOME Ski complex component and WD-repeat protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; also required for meiotic double-strand break recombination; null mutants have superkiller phenotype nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|protein complex assembly|nuclear-transcribed mRNA catabolic process, non-stop decay|protein-DNA complex assembly|reciprocal meiotic recombination molecular_function Ski complex|nuclear chromosome
YOR252W YOR252W TMA16 hom Verified 0.260583751158047 0.397206760782337 no 1836 0.392957106386623 1325 NA FT NUCLEUS Protein of unknown function that associates with ribosomes biological_process molecular_function ribosome|nucleus
YML067C YML067C ERV41 hom Verified 0.259297975918571 0.397702670500795 no 1837 0.399817794174676 1298 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Protein localized to COPII-coated vesicles, forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 (PTX1) protein ER to Golgi vesicle-mediated transport molecular_function integral to endoplasmic reticulum membrane|integral to Golgi membrane|ER to Golgi transport vesicle
YOR120W YOR120W GCY1 hom Verified 0.259077313511119 0.397787794270607 no 1838 0.418402418981854 1362 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS NUCLEUS Glycerol dehydrogenase;involved in an alternative pathway for glycerol catabolism used under microaerobic conditions; also has mRNA binding activity; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress; GCY1 has a paralog, YPR1, that arose from the whole genome duplication cellular response to oxidative stress|arabinose catabolic process|D-xylose catabolic process oxidoreductase activity|mRNA binding|alditol:NADP+ 1-oxidoreductase activity|aldo-keto reductase (NADP) activity nucleus|cytoplasm
YGR059W YGR059W SPR3 hom Verified 0.258766450277651 0.3979077225922 no 1839 0.398915177464116 1329 NA FT CELL CYCLE SITE OF POLARIZED GROWTH|CYTOSKELETON Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; septin protein involved in sporulation; regulated by ABFI ascospore formation structural molecule activity septin complex|ascospore wall|prospore membrane
YGL035C YGL035C MIG1 hom Verified 0.258581603100921 0.397979039593856 no 1840 0.414236015173626 1364 NA FT TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS ENDOMEMBRANE SYSTEM|NUCLEUS Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion negative regulation of transcription from RNA polymerase II promoter by glucose|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding nucleus|nuclear envelope lumen|cytoplasm
YLR349W_d YLR349W YLR349W hom Dubious 0.257915609763264 0.398236018741789 no 1841 0.396355027243437 1300 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF DIC1/YLR348C Unknown Unknown Unknown
YGR208W YGR208W SER2 hom Verified 0.25787845122426 0.398250357978767 no 1842 0.389105814158068 1303 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source L-serine biosynthetic process phosphoserine phosphatase activity nucleus|cytoplasm
YCR107W YCR107W AAD3 hom Verified 0.256702261282538 0.398704312890499 no 1843 0.406846998057164 1335 NA FT OXIDATION-REDUCTION PROCESS Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role cellular aldehyde metabolic process aryl-alcohol dehydrogenase (NAD+) activity cellular_component
YML052W YML052W SUR7 hom Verified 0.256622427159216 0.398735130143968 no 1844 0.380733365449563 1283 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION MITOCHONDRION|PLASMA MEMBRANE Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants endocytosis|ascospore formation molecular_function cell cortex|eisosome|mitochondrion|membrane raft|integral to membrane|plasma membrane|actin cortical patch
YCR036W YCR036W RBK1 hom Verified 0.256536787438754 0.398768189153051 no 1845 0.421265668923414 1384 NA FT CARBOHYDRATE METABOLISM NUCLEUS Putative ribokinase D-ribose metabolic process ribokinase activity|ATP binding nucleus|cytoplasm
YIL006W YIL006W YIA6 hom Verified 0.256274506862924 0.39886944033374 no 1846 0.4104959093467 1354 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Mitochondrial NAD+ transporter, involved in the transport of NAD+ into the mitochondria (see also YEA6); member of the mitochondrial carrier subfamily; disputed role as a pyruvate transporter; has putative mouse and human orthologs transport|mitochondrial pyruvate transport|NAD transmembrane transport pyruvate secondary active transmembrane transporter activity|transporter activity|NAD transporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YCR063W YCR063W BUD31 hom Verified 0.255647606502839 0.399111477436815 no 1847 0.370812256729241 1233 NA FT CELL CYCLE|RNA PROCESSING|CELL DIVISION NUCLEUS Component of the SF3b subcomplex of the U2 snRNP; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; facilitates passage through G1/S Start, but is not required for G2/M transition or exit from mitosis RNA splicing|mRNA splicing, via spliceosome|cellular bud site selection molecular_function U2 snRNP|nucleus
YJR078W YJR078W BNA2 hom Verified 0.255104617821432 0.399321148817493 no 1848 0.390775813865394 1292 NA FT OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for de novo biosynthesis of NAD from tryptophan via kynurenine; interacts genetically with telomere capping gene CDC13; regulated by Hst1p and Aftp de novo NAD biosynthetic process from tryptophan tryptophan 2,3-dioxygenase activity|indoleamine 2,3-dioxygenase activity cytoplasm
YKL147C_d YKL147C YKL147C hom Dubious 0.253035366863995 0.400120441735111 no 1849 0.373533006642183 1223 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene AVT3 Unknown Unknown Unknown
YBR095C YBR095C RXT2 hom Verified 0.252907869430055 0.400169704099259 no 1850 0.420214241278109 1359 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Subunit of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth conjugation with cellular fusion|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of transcription from RNA polymerase II promoter|negative regulation of chromatin silencing at telomere|negative regulation of chromatin silencing at rDNA|invasive growth in response to glucose limitation histone deacetylase activity Rpd3L-Expanded complex|nucleus|Rpd3L complex
YDL197C YDL197C ASF2 hom Verified 0.252376154190495 0.40037516495746 no 1851 0.393351661054664 1294 NA FT GENE SILENCING NUCLEUS|CHROMOSOME Anti-silencing protein that causes derepression of silent loci when overexpressed chromatin silencing at silent mating-type cassette molecular_function nuclear chromosome, telomeric region|nucleus
YGL139W YGL139W FLC3 hom Verified 0.249799299542663 0.401371280731374 no 1852 0.39697921205675 1307 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER FAD transport|transmembrane transport FAD transmembrane transporter activity mitochondrion|integral to membrane|endoplasmic reticulum
YAL026C YAL026C DRS2 hom Verified 0.249610275376685 0.401444375740818 no 1853 0.401185600149662 1325 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RIBOSOME BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS GOLGI APPARATUS Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation and endocytosis; mutations in human homolog ATP8B1 result in liver disease intracellular protein transport|post-Golgi vesicle-mediated transport|phospholipid translocation|endocytosis|ribosomal small subunit assembly phospholipid-translocating ATPase activity trans-Golgi network|integral to membrane
YNR051C YNR051C BRE5 hom Verified 0.249360331176963 0.401541033617366 no 1854 0.397501833850811 1327 NA FT VESICLE-MEDIATED TRANSPORT Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A protein deubiquitination|ribophagy|regulation of ER to Golgi vesicle-mediated transport|Unknown molecular_function cytoplasm
YPL232W YPL232W SSO1 hom Verified 0.249355524825371 0.401542892378243 no 1855 0.40599180822016 1357 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION PLASMA MEMBRANE Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p ascospore formation|ascospore-type prospore assembly|vesicle fusion phosphatidic acid binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|SNAP receptor activity SNARE complex|fungal-type vacuole membrane|plasma membrane|prospore membrane
YNL005C YNL005C MRP7 hom Verified 0.248997425406922 0.401681386468753 no 1856 0.428685037284148 1409 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome|peptidyltransferase activity mitochondrion|mitochondrial large ribosomal subunit
YDL242W_d YDL242W YDL242W hom Dubious 0.247763197383769 0.402158815722305 no 1857 0.386914071559464 1260 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOL048C YOL048C RRT8 hom Verified 0.247725877053931 0.40217325440644 no 1858 0.396443592877822 1283 NA Protein of unknown function; identified in a screen for mutants with increased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to lipid particles; protein abundance increases in response to DNA replication stress biological_process molecular_function integral to membrane|lipid particle
YER076C_p YER076C YER076C hom Uncharacterized 0.247006037190062 0.402451775908798 no 1859 0.401297706438756 1317 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; analysis of HA-tagged protein suggests a membrane localization biological_process molecular_function mitochondrion
YIL113W YIL113W SDP1 hom Verified 0.246817276252077 0.402524819771404 no 1860 0.422096667218227 1392 NA FT SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION NUCLEUS Stress-inducible dual-specificity MAP kinase phosphatase, negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock inactivation of MAPK activity involved in cell wall biogenesis|MAPK cascade involved in cell wall biogenesis MAP kinase tyrosine phosphatase activity nucleus|cytoplasm
YGL108C YGL108C YGL108C hom Verified 0.246742615562968 0.402553711778886 no 1861 0.401872781612391 1328 NA Protein of unknown function, predicted to be palmitoylated; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; protein abundance increases in response to DNA replication stress biological_process molecular_function cellular_component
YDR358W YDR358W GGA1 hom Verified 0.246028078514643 0.402830248446422 no 1862 0.400303118604253 1297 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT GOLGI APPARATUS Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi Golgi to vacuole transport|protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|Golgi to endosome transport ubiquitin binding trans-Golgi network
YNL116W YNL116W DMA2 hom Verified 0.24575455499136 0.402936119070442 no 1863 0.439129692807322 1449 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION Ubiquitin-protein ligase (E3); controls septin dynamics and the spindle position checkpoint (SPOC) along with functionally redundant ligase Dma1p by regulating the recruitment of Elm1p to the bud neck; regulates levels of the translation initiation factor eIF2 subunit Gcd11p, as well as abundance, localization, and ubiquitination of Cdk inhibitory kinase Swe1p; ortholog of human RNF8 protein, with sequence similarity to human Chfr; contains FHA and RING finger domains establishment of mitotic spindle orientation|protein autoubiquitination|septin ring assembly|mitotic cell cycle spindle assembly checkpoint ubiquitin-protein ligase activity cytoplasm
YJR082C YJR082C EAF6 hom Verified 0.245468657981997 0.403046786610446 no 1864 0.396939725649614 1322 NA FT CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS HISTONE ACETYLTRANSFERASE Subunit of the NuA4 acetyltransferase complex that acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3 DNA repair|histone acetylation histone acetyltransferase activity nucleus|NuA4 histone acetyltransferase complex|NuA3 histone acetyltransferase complex
YLR137W YLR137W RKM5 hom Verified 0.244970936147805 0.403239467700244 no 1865 0.393024072045609 1290 NA Protein lysine methyltransferase; monomethylates Lys-46 of the ribosomal large subunit Rpl1a/Rpl1b; member of the seven beta-strand methyltransferase superfamily; orthologs only found among fungal species protein methylation S-adenosylmethionine-dependent methyltransferase activity cellular_component
YGR164W_d YGR164W YGR164W hom Dubious 0.244890956384324 0.403270432142697 no 1866 0.40273669733847 1365 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR218C YLR218C COA4 hom Verified 0.243784324214732 0.403698930788744 no 1867 0.382601920881224 1248 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION NUCLEUS|MITOCHONDRION Twin Cx(9)C protein involved in cytochrome c oxidase assembly or stability; localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; interacts genetically with CYC1 and with cytochrome c oxidase assembly factors mitochondrial respiratory chain complex IV assembly|mitochondrial respiratory chain complex assembly molecular_function nucleus|mitochondrial intermembrane space|cytoplasm
YOR348C YOR348C PUT4 hom Verified 0.242914372287151 0.404035865756917 no 1868 0.410751883548462 1370 NA FT PLASMA MEMBRANE Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells neutral amino acid transport|proline transport|gamma-aminobutyric acid transport neutral amino acid transmembrane transporter activity|L-proline transmembrane transporter activity integral to membrane|plasma membrane
YER024W YER024W YAT2 hom Verified 0.242301668115701 0.404273210656168 no 1869 0.411460301276692 1353 NA FT KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane carnitine metabolic process|alcohol metabolic process carnitine O-acetyltransferase activity cytosol|cytoplasm
YER124C YER124C DSE1 hom Verified 0.24229274127848 0.404276668930293 no 1870 0.400730961011834 1329 NA FT CELL CYCLE|SIGNALING|CELL WALL ORG/BIOGENESIS|CELL DIVISION SITE OF POLARIZED GROWTH Daughter cell-specific protein, may regulate cross-talk between the mating and filamentation pathways; deletion affects cell separation after division and sensitivity to alpha-factor and drugs affecting the cell wall; relocalizes from bud neck to cytoplasm upon DNA replication stress cytokinesis, completion of separation|regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion|invasive growth in response to glucose limitation molecular_function cellular bud neck
YJL043W_p YJL043W YJL043W hom Uncharacterized 0.242025457499967 0.404380218650325 no 1871 0.367824907756645 1243 NA FT MITOCHONDRION Putative protein of unknown function; YJL043W is a non-essential gene biological_process molecular_function mitochondrion|cytoplasm
YDR515W YDR515W SLF1 hom Verified 0.241900357404397 0.404428686593954 no 1872 0.411476684700162 1348 NA FT TRANSLATION|ION HOMEOSTASIS|ION HOMEOSTASIS RNA binding protein that associates with polysomes; may be involved in regulating mRNA translation; involved in the copper-dependent mineralization of copper sulfide complexes on cell surface in cells cultured in copper salts; SLF1 has a paralog, SRO9, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress cellular copper ion homeostasis|regulation of translation RNA binding polysome|cytoplasm
YOR031W YOR031W CRS5 hom Verified 0.241802313390324 0.404466673135731 no 1873 0.40306209960517 1293 NA Copper-binding metallothionein, required for wild-type copper resistance response to metal ion copper ion binding cytoplasm
YDL225W YDL225W SHS1 hom Verified 0.241519467172713 0.404576265184044 no 1874 0.39413168647498 1327 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins; undergoes sumoylation and phosphorylation during mitosis; protein abundance increases in response to DNA replication stress cytokinesis, actomyosin contractile ring assembly|G1 phase of mitotic cell cycle|barrier septum assembly|exit from mitosis|cell cycle cytokinesis|septin ring assembly|cellular bud neck septin ring organization GTP binding cellular bud neck septin ring|mating projection tip
YHR035W_p YHR035W YHR035W hom Uncharacterized 0.241238747362802 0.404685040733632 no 1875 0.376136251288875 1287 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM Putative protein of unknown function; not an essential gene biological_process molecular_function cellular_component
YGR123C YGR123C PPT1 hom Verified 0.240639241072204 0.404917366864422 no 1876 0.409538158049971 1331 NA FT NUCLEUS Protein serine/threonine phosphatase, regulates Hsp90 chaperone by affecting its ATPase and cochaperone binding activities; has similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth protein dephosphorylation protein serine/threonine phosphatase activity nucleus|cytoplasm
YGL124C YGL124C MON1 hom Verified 0.240444967559006 0.404992660698096 no 1877 0.412613772535157 1355 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT Protein required for fusion of cvt-vesicles and autophagosomes with the vacuole; associates, as a complex with Ccz1p, with a perivacuolar compartment; potential Cdc28p substrate autophagy|vesicle docking|protein targeting to vacuole molecular_function cytosol|fungal-type vacuole membrane|Mon1-Ccz1 complex
YBR026C YBR026C ETR1 hom Verified 0.239801740053778 0.405241978979325 no 1878 0.432386092372176 1411 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION 2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family; localized to in mitochondria, where it has a probable role in fatty acid synthesis fatty acid biosynthetic process|aerobic respiration enoyl-[acyl-carrier-protein] reductase activity mitochondrion
YIR039C YIR039C YPS6 hom Verified 0.23942788317343 0.405386905503425 no 1879 0.429687816410808 1439 NA FT CELL WALL ORG/BIOGENESIS|PROTEOLYSIS PLASMA MEMBRANE Putative GPI-anchored aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance fungal-type cell wall organization aspartic-type endopeptidase activity fungal-type cell wall
YHR028C YHR028C DAP2 hom Verified 0.239103966240775 0.405512483176179 no 1880 0.418638729599092 1373 NA FT PROTEOLYSIS Dipeptidyl aminopeptidase, synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p protein processing dipeptidyl-peptidase activity fungal-type vacuole membrane
YGR052W_p YGR052W FMP48 hom Uncharacterized 0.238129044036358 0.40589050434214 no 1881 0.440147203320319 1460 NA FT PROTEIN PHOSPHORYLATION MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation protein phosphorylation protein kinase activity mitochondrion
YIL097W YIL097W FYV10 hom Verified 0.237975345598126 0.405950108154124 no 1882 0.412258725757965 1369 NA FT KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS NUCLEUS Subunit of GID complex; involved in proteasome-dependent catabolite inactivation of gluconeogenic enzymes FBPase, PEPCK, and c-MDH; forms dimer with Rmd5p that is then recruited to GID Complex by Gid8p; contains a degenerate RING finger motif needed for GID complex ubiquitin ligase activity in vivo, as well as CTLH and CRA domains; plays role in anti-apoptosis; required for survival upon exposure to K1 killer toxin negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis ubiquitin-protein ligase activity nucleus|GID complex|cytoplasm
YOR034C-A_p YOR034C-A YOR034C-A hom Uncharacterized 0.237929630591216 0.405967836722947 no 1883 0.414382436663065 1366 NA Putative protein of unknown function; identified by expression profiling and mass spectrometry biological_process molecular_function cellular_component
YDL107W YDL107W MSS2 hom Verified 0.237790411219802 0.406021828063411 no 1884 0.416231281247488 1384 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Peripherally bound inner membrane protein of the mitochondrial matrix involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p protein insertion into mitochondrial membrane from inner side molecular_function extrinsic to mitochondrial inner membrane|mitochondrial matrix
YBR194W YBR194W AIM4 hom Verified 0.237637363437785 0.406081184329447 no 1885 0.434693512083553 1428 NA Protein proposed to be associated with the nuclear pore complex; null mutant is viable, displays elevated frequency of mitochondrial genome loss and is sensitive to freeze-thaw stress biological_process molecular_function cytoplasm
YLR015W YLR015W BRE2 hom Verified 0.237575632077005 0.406105126111196 no 1886 0.41842196032192 1373 NA FT CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Subunit of COMPASS (Set1C) complex, which methylates Lys4 of histone H3 and functions in silencing at telomeres; has a C-terminal Sdc1 Dpy-30 Interaction (SDI) domain that mediates binding to Sdc1p; similar to trithorax-group protein ASH2L histone H3-K4 methylation|telomere maintenance|histone H3-K4 trimethylation|chromatin silencing at telomere histone methyltransferase activity (H3-K4 specific) Set1C/COMPASS complex
YJL062W-A YJL062W-A COA3 hom Verified 0.23725680706983 0.40622878422582 no 1887 0.402257326606748 1344 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly mitochondrial respiratory chain complex IV assembly|negative regulation of mitochondrial translation molecular_function mitochondrion|mitochondrial inner membrane|integral to mitochondrial inner membrane
YPL159C YPL159C PET20 hom Verified 0.23588146726289 0.406762324749462 no 1888 0.41093003853662 1353 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Mitochondrial protein, required for respiratory growth under some conditions and for stability of the mitochondrial genome aerobic respiration molecular_function mitochondrion
YCL064C YCL064C CHA1 hom Verified 0.235621271107073 0.406863283083971 no 1889 0.409100567897033 1349 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine threonine catabolic process|L-serine catabolic process L-threonine ammonia-lyase activity|L-serine ammonia-lyase activity mitochondrial nucleoid|mitochondrion
YOR322C YOR322C LDB19 hom Verified 0.235619888364935 0.40686381961629 no 1890 0.433834811049071 1416 NA FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION GOLGI APPARATUS|PLASMA MEMBRANE Protein involved in regulating the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target; inhibited by Npr1p-mediated phosphorylation, which affects translocation between the cytosol and the plasma membrane; null mutant has reduced affinity for alcian blue dye ubiquitin-dependent endocytosis ubiquitin protein ligase binding cytosol|Golgi apparatus|plasma membrane|clathrin-coated vesicle|cytoplasm
YDR111C_p YDR111C ALT2 hom Uncharacterized 0.235082527423444 0.407072339910934 no 1891 0.404734145794506 1309 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Catalytically inactive paralog of ALT1, an alanine transaminase; expression is repressed in the presence of alanine and repression is mediated by Nrg1p biological_process transaminase activity nucleus|cytoplasm
YDR337W YDR337W MRPS28 hom Verified 0.234889860944198 0.407147109617973 no 1892 0.418300374171294 1378 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit mitochondrial translation structural constituent of ribosome|RNA binding mitochondrion|mitochondrial small ribosomal subunit
YJL059W YJL059W YHC3 hom Verified 0.234324916663154 0.407366371812602 no 1893 0.403162160211496 1346 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT Vacuolar membrane protein involved in the ATP-dependent transport of arginine into the vacuole and possibly in balancing ion homeostasis; homolog of human CLN3 involved in Batten disease (juvenile onset neuronal ceroid lipofuscinosis) basic amino acid transport|regulation of intracellular pH|arginine transport molecular_function integral to membrane|fungal-type vacuole
YKL076C_d YKL076C PSY1 hom Dubious 0.234133199968631 0.407440786145699 no 1894 0.412901744573822 1393 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C Unknown Unknown Unknown
YFR033C YFR033C QCR6 hom Verified 0.234008495551915 0.407489191631781 no 1895 0.418779016702381 1351 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Subunit 6 of the ubiquinol cytochrome-c reductase complex; the complex, also known as the cytochrome bc(1) complex or Complex III, is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1; may be loosely associated with the complex since it is easily released into the intermembrane space mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration ubiquinol-cytochrome-c reductase activity mitochondrion|integral to membrane|mitochondrial respiratory chain complex III
YER041W YER041W YEN1 hom Verified 0.233349924938983 0.407744846972357 no 1896 0.40640456644471 1371 NA FT RESPONSE TO DNA DAMAGE NUCLEUS Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p DNA repair|response to DNA damage stimulus single-stranded DNA specific endodeoxyribonuclease activity|crossover junction endodeoxyribonuclease activity nucleus|cytoplasm
YDR179W-A_p YDR179W-A YDR179W-A hom Uncharacterized 0.23317422860659 0.407813058459788 no 1897 0.413553527897722 1353 NA Putative protein of unknown function biological_process molecular_function cellular_component
YPL239W YPL239W YAR1 hom Verified 0.232934681850284 0.407906063426519 no 1898 0.393489229895807 1320 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RESPONSE TO OXIDATIVE STRESS Ankyrin-repeat containing, nucleocytoplasmic shuttling chaperone; prevents aggregation of Rps3p in the cytoplasm, associates with free Rps3p in the cytoplasm and delivers it to the 90S in the nucleus; required for 40S ribosomal subunit export, biogenesis and adaptation to osmotic and oxidative stress; expression repressed by heat shock ribosomal small subunit biogenesis|cellular response to oxidative stress|response to osmotic stress molecular_function cytoplasm
YNL184C_p YNL184C YNL184C hom Uncharacterized 0.232683791747414 0.408003478056064 no 1899 0.407924806943923 1364 NA Protein of unknown function; expressed at both mRNA and protein levels biological_process molecular_function cellular_component
YMR060C YMR060C SAM37 hom Verified 0.231825117628996 0.40833692369443 no 1900 0.440450541545721 1466 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; contributes to SAM complex stability mitochondrial outer membrane translocase complex assembly|protein import into mitochondrial outer membrane|phospholipid transport molecular_function mitochondrial outer membrane|mitochondrial sorting and assembly machinery complex|mitochondrion|integral to membrane
YBR290W YBR290W BSD2 hom Verified 0.23148535231527 0.408468881803122 no 1901 0.418294404344389 1393 NA FT PROTEIN LOCALIZATION|ION HOMEOSTASIS|PROTEOLYSIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT ENDOPLASMIC RETICULUM Heavy metal ion homeostasis protein, facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded, controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification metal ion transport|ubiquitin-dependent protein catabolic process|protein targeting to vacuole protein binding fungal-type vacuole membrane|integral to membrane|endoplasmic reticulum
YBR242W_p YBR242W YBR242W hom Uncharacterized 0.23007122934414 0.409018210448398 no 1902 0.439604368166162 1448 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR242W is not an essential gene biological_process molecular_function nucleus|cytoplasm
YGR279C YGR279C SCW4 hom Verified 0.229985666881624 0.409051453693379 no 1903 0.41603525863226 1375 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating conjugation with cellular fusion glucosidase activity extracellular region|fungal-type cell wall
YGR138C YGR138C TPO2 hom Verified 0.229471766046593 0.409251131306916 no 1904 0.376060390949991 1251 NA FT PLASMA MEMBRANE Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; TPO2 has a paralog, TPO3, that arose from the whole genome duplication spermine transport spermine transmembrane transporter activity fungal-type vacuole membrane|integral to membrane|plasma membrane
YDR522C YDR522C SPS2 hom Verified 0.228653418268307 0.409569151222319 no 1905 0.390584054193153 1300 NA FT CELL CYCLE|CELL WALL ORG/BIOGENESIS PLASMA MEMBRANE Protein expressed during sporulation; SPS2 has a paralog, SPS22, that arose from the whole genome duplication; redundant with Sps22p for organization of the beta-glucan layer of the spore wall; S. pombe ortholog is a spore wall component ascospore wall assembly|ascospore formation molecular_function fungal-type cell wall|plasma membrane
YPR038W_d YPR038W IRC16 hom Dubious 0.228640024134009 0.409574356841622 no 1906 0.401832314234987 1330 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene YPR037C; null mutant displays increased levels of spontaneous Rad52p foci Unknown Unknown Unknown
YDL101C YDL101C DUN1 hom Verified 0.228191668253938 0.409748619179315 no 1907 0.413316239150737 1359 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION NUCLEUS Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; also regulates postreplicative DNA repair protein phosphorylation|replication fork protection|cell cycle checkpoint|DNA damage checkpoint protein kinase activity nucleus
YDR130C YDR130C FIN1 hom Verified 0.227769015728233 0.409912907728951 no 1908 0.421388730286077 1400 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME|CYTOSKELETON KINETOCHORE Spindle pole body-related intermediate filament protein; forms cell cycle-specific filaments between spindle pole bodies in dividing cells; localizes to poles and microtubules of spindle during anaphase and contributes to spindle stability; involved in Glc7p localization and regulation; relative distribution to the nucleus increases upon DNA replication stress intermediate filament cytoskeleton organization|mitotic cell cycle spindle checkpoint|mitotic spindle stabilization|mitotic sister chromatid segregation microtubule binding|structural constituent of cytoskeleton spindle microtubule|condensed nuclear chromosome kinetochore|intermediate filament|nucleus|spindle pole body|astral microtubule|spindle
YKR073C_d YKR073C YKR073C hom Dubious 0.227252360945884 0.410113757218364 no 1909 0.438801017082794 1434 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPR147C_p YPR147C YPR147C hom Uncharacterized 0.226937506923495 0.410236168253064 no 1910 0.410592562271578 1381 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS biological_process molecular_function cytoplasm
YPL123C YPL123C RNY1 hom Verified 0.226658561686424 0.410344625739835 no 1911 0.400602636975155 1334 NA Vacuolar RNase of the T(2) family, relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; promotes apoptosis under stress conditions and this function is independent of its catalytic activity cell morphogenesis|RNA catabolic process|apoptotic process endoribonuclease activity cytosol|extracellular region|vacuole
YJL120W_d YJL120W YJL120W hom Dubious 0.225740604849771 0.410701587505963 no 1912 0.447173063153483 1474 NA FF Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL121C/RPE1; deletion confers sensitivity to GSAO Unknown Unknown Unknown
YDR492W YDR492W IZH1 hom Verified 0.225560531759206 0.410771620410974 no 1913 0.408290405725802 1371 NA FT LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc response to zinc ion|cellular zinc ion homeostasis|cellular lipid metabolic process metal ion binding integral to membrane|endoplasmic reticulum|membrane
YLL059C_d YLL059C YLL059C hom Dubious 0.225209496158362 0.41090815116656 no 1914 0.419207044403879 1379 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOR029W_d YOR029W YOR029W hom Dubious 0.225190984733287 0.410915351245614 no 1915 0.374087578482967 1236 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YHR050W-A_p YHR050W-A YHR050W-A hom Uncharacterized 0.225161203784425 0.410926934705622 no 1916 0.415045186467666 1357 NA Protein of unknown function; identified by expression profiling and mass spectrometry biological_process molecular_function cellular_component
YBR204C YBR204C LDH1 hom Verified 0.223868639466055 0.411429759251341 no 1917 0.4131939613867 1358 NA FT LIPID METABOLISM Serine hydrolase; exhibits active esterase plus weak triacylglycerol lipase activities; proposed role in lipid homeostasis, regulating phospholipid and non-polar lipid levels and required for mobilization of LD-stored lipids; localizes to the lipid droplet (LD) surface; contains a classical serine containing catalytic triad (GxSxG motif) lipid homeostasis hydrolase activity, acting on ester bonds|serine hydrolase activity|triglyceride lipase activity lipid particle
YKL201C YKL201C MNN4 hom Verified 0.223852466339691 0.411436051733996 no 1918 0.409032639755579 1374 NA FT CARBOHYDRATE METABOLISM Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication protein O-linked glycosylation|protein N-linked glycosylation|response to stress molecular_function membrane
YER007W YER007W PAC2 hom Verified 0.222611124108725 0.41191908895176 no 1919 0.413724498464523 1360 NA FT CYTOSKELETON Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl protein folding|tubulin complex assembly|tubulin complex biogenesis alpha-tubulin binding cellular_component
YBR301W YBR301W PAU24 hom Verified 0.221721787361047 0.412265234181463 no 1920 0.418098145970967 1372 NA FT CELL WALL ORG/BIOGENESIS Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth biological_process molecular_function fungal-type cell wall
YML048W YML048W GSF2 hom Verified 0.221598907598182 0.412313066481819 no 1921 0.424713145196471 1402 NA FF|FT PROTEIN LOCALIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression protein folding|protein localization to cell surface unfolded protein binding mitochondrial outer membrane|integral to endoplasmic reticulum membrane|cytoplasm
YHL023C YHL023C NPR3 hom Verified 0.220311919175126 0.412814119021926 no 1922 0.430896131540448 1439 NA FT CELL CYCLE|SIGNALING|RESPONSE TO NUTRIENT LEVELS Subunit of SEA (Seh1-associated), Npr2/3, and Iml1p complexes; Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation; SEA complex is a coatomer-related complex that associates dynamically with the vacuole; Iml1p complex (Iml1p-Npr2p-Npr3p) is required for non-nitrogen-starvation (NNS)-induced autophagy; required for Npr2p phosphorylation and Iml1p-Npr2p interaction; null mutant shows delayed meiotic DNA replication and double-strand break repair meiosis|regulation of TOR signaling cascade|cellular response to amino acid starvation molecular_function Seh1-associated complex|extrinsic to fungal-type vacuolar membrane
YNL128W YNL128W TEP1 hom Verified 0.220048275469348 0.412916778802395 no 1923 0.40476655352075 1333 NA FT CELL WALL ORG/BIOGENESIS PTEN homolog with no demonstrated inositol lipid phosphatase activity; plays a role in normal sporulation; homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 and fission yeast ptn1 ascospore wall assembly|phosphatidylinositol dephosphorylation molecular_function cytoplasm
YLR104W_p YLR104W LCL2 hom Uncharacterized 0.219740300214608 0.413036708312227 no 1924 0.418137815569942 1355 NA FT PROTEOLYSIS Putative protein of unknown function; mutant is deficient in amounts of cell wall mannosylphosphate and has long chronological lifespan; genetic interactions suggest a role in ER-associated protein degradation (ERAD) ER-associated protein catabolic process molecular_function cellular_component
YOL083W YOL083W ATG34 hom Verified 0.219485424436918 0.413135966343877 no 1925 0.409746282623647 1325 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS Receptor protein involved in selective autophagy during starvation; specifically involved in the transport of cargo protein alpha-mannosidase (Ams1p); Atg19p paralog protein complex assembly|protein complex localization protein binding, bridging CVT complex
YKR051W_p YKR051W YKR051W hom Uncharacterized 0.219360906246118 0.413184460340994 no 1926 0.416041148983984 1356 NA Putative protein of unknown function biological_process molecular_function integral to membrane
YKL216W YKL216W URA1 hom Verified 0.218608570548759 0.413477487974513 no 1927 0.400903434731538 1316 NA FT OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid 'de novo' pyrimidine nucleobase biosynthetic process dihydroorotate dehydrogenase activity extrinsic to membrane|cytoplasm
YBL088C YBL088C TEL1 hom Verified 0.218569086475497 0.413492867979846 no 1928 0.412583027398468 1356 NA FT CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION NUCLEUS|MITOCHONDRION|CHROMOSOME Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; regulates P-body formation induced by replication stress; homolog of human ataxia-telangiectasia mutated (ATM) gene, the gene responsible for ataxia telangiectasia (AT) (OMIM 607585) double-strand break repair|histone phosphorylation|telomere maintenance|response to DNA damage stimulus|phosphorylation|DNA damage induced protein phosphorylation protein kinase activity|telomeric DNA binding mitochondrion|nucleus
YGL086W YGL086W MAD1 hom Verified 0.218270951308058 0.413609003150459 no 1929 0.409256314972987 1344 NA FT CELL CYCLE|CELL DIVISION ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME NUCLEAR PORE|KINETOCHORE Coiled-coil protein involved in the spindle-assembly checkpoint; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon spindle assembly checkpoint arrest; phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of the activity of the anaphase promoting complex; forms a complex with Mad2p nucleocytoplasmic transport|mitotic cell cycle spindle assembly checkpoint|mitotic cell cycle G2/M transition decatenation checkpoint molecular_function nucleus|nuclear pore|kinetochore
YHL015W-A_p YHL015W-A YHL015W-A hom Uncharacterized 0.218173165400027 0.413647096187478 no 1930 0.401802088254183 1323 NA Putative protein of unknown function biological_process molecular_function cellular_component
YFL049W YFL049W SWP82 hom Verified 0.21799360297883 0.413717047829997 no 1931 0.406114170211791 1333 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS RSC COMPLEX Member of the SWI/SNF chromatin remodeling complex; has an as yet unidentified role in the complex; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p; relocates to the cytosol under hypoxic conditions positive regulation of transcription from RNA polymerase II promoter molecular_function SWI/SNF complex|nucleus
YGL167C YGL167C PMR1 hom Verified 0.217675065111854 0.413841146493641 no 1932 0.434913146613886 1447 NA FT VESICLE-MEDIATED TRANSPORT|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|GOLGI APPARATUS High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease manganese ion transport|calcium ion transport|exocytosis manganese-transporting ATPase activity|calcium-transporting ATPase activity|calcium ion binding integral to membrane|Golgi membrane
YNL081C YNL081C SWS2 hom Verified 0.217035219468635 0.414090448935763 no 1933 0.433795565513323 1429 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency regulation of sporulation resulting in formation of a cellular spore|mitochondrial translation structural constituent of ribosome mitochondrial small ribosomal subunit|cytoplasm
YPL035C_d YPL035C YPL035C hom Dubious 0.216351157794352 0.414357017519366 no 1934 0.418897221432583 1386 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene Unknown Unknown Unknown
YBR191W YBR191W RPL21A hom Verified 0.216156914888487 0.414432718266428 no 1935 0.414981140761343 1356 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YLR191W YLR191W PEX13 hom Verified 0.216009757929726 0.41449007069709 no 1936 0.418095399157372 1395 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PEROXISOME ORGANIZATION Integral peroxisomal membrane protein required for translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p protein import into peroxisome matrix, docking protein binding, bridging peroxisomal membrane
YJR084W YJR084W YJR084W hom Verified 0.215783814360432 0.414578132689735 no 1937 0.400932358281498 1300 NA FT RNA PROCESSING|SIGNALING NUCLEUS|CHROMOSOME Protein that forms a complex with Thp3p; may have a role in transcription elongation and/or mRNA splicing; identified as a COP9 signalosome component but phenotype and interactions suggest it may not be involved with the signalosome adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|mRNA splicing, via spliceosome molecular_function transcriptionally active chromatin
YIL036W YIL036W CST6 hom Verified 0.214508172283633 0.415075397361639 no 1938 0.320326682190787 1121 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS NUCLEUS Basic leucine zipper (bZIP) transcription factor, in ATF/CREB family; mediates transcriptional activation of NCE103 (encoding carbonic anhydrase) in response to low CO2 levels such as in the ambient air; proposed to be a regulator of oleate responsive genes; involved in utilization of non-optimal carbon sources and chromosome stability; CST6 has a paralog, ACA1, that arose from the whole genome duplication cellular response to carbon dioxide|positive regulation of transcription from RNA polymerase II promoter by oleic acid|cellular response to oleic acid|positive regulation of transcription from RNA polymerase II promoter|DNA metabolic process sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YNL326C YNL326C PFA3 hom Verified 0.214217665811644 0.415188660252871 no 1939 0.429724747233915 1435 NA FT MEMBRANE ORGANIZATION Palmitoyltransferase for Vac8p, required for vacuolar membrane fusion; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; autoacylates; required for vacuolar integrity under stress conditions vacuole fusion, non-autophagic|protein palmitoylation palmitoyltransferase activity fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YOR251C YOR251C TUM1 hom Verified 0.213218376494004 0.415578317724279 no 1940 0.391455301565252 1294 NA FT RNA PROCESSING MITOCHONDRION Rhodanese domain sulfur transferase, accepts persulfite from Nfs1p and transfers it to Uba4p in the pathway for 2-thiolation of the wobble uridine base of tRNAs; also stimulates sulfur transfer by Nfs1p; may be mitochondrially localized tRNA wobble position uridine thiolation|tRNA wobble uridine modification thiosulfate sulfurtransferase activity cytoplasm
YJR033C YJR033C RAV1 hom Verified 0.212926342591755 0.415692207539441 no 1941 0.425031869572663 1399 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate early endosome to late endosome transport|vacuolar acidification|regulation of protein complex assembly molecular_function RAVE complex|cytoplasm|extrinsic to membrane
YBR138C_p YBR138C YBR138C hom Uncharacterized 0.211653025097653 0.416188869145471 no 1942 0.371731028256332 1248 NA Cytoplasmic protein of unknown function, potentially phosphorylated by Cdc28p; YBR138C is not an essential gene biological_process molecular_function cytoplasm
YPL001W YPL001W HAT1 hom Verified 0.211266778287951 0.416339552460698 no 1943 0.425309658132651 1438 NA FT CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING NUCLEUS HISTONE ACETYLTRANSFERASE Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A, to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair histone acetylation|chromatin silencing at telomere histone acetyltransferase activity|histone binding histone acetyltransferase complex|nucleus|cytoplasm
YGL220W YGL220W FRA2 hom Verified 0.21113767499486 0.416389921217667 no 1944 0.4082281939767 1344 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; null mutant fails to repress iron regulon and is sensitive to nickel negative regulation of transcription from RNA polymerase II promoter in response to iron molecular_function cytosol|nucleus|cytoplasm
YDR517W YDR517W GRH1 hom Verified 0.211004910936855 0.416441719628692 no 1945 0.408240732244504 1376 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Acetylated cis-Golgi protein, involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes; protein abundance increases in response to DNA replication stress protein secretion|ER to Golgi vesicle-mediated transport|Golgi organization molecular_function COPII vesicle coat|cis-Golgi network|cytoplasm
YGL209W YGL209W MIG2 hom Verified 0.210761178140202 0.4165368166992 no 1946 0.414637865076693 1371 NA FT TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS NUCLEUS|MITOCHONDRION Zinc finger transcriptional repressor; cooperates with Mig1p in glucose-induced repression of many genes; under low glucose conditions Mig2p relocalizes to mitochondrion, where it interacts with Ups1p and antagonizes mitochondrial fission factor, Dnm1p, indicative of a role in mitochondrial fusion or regulating morphology; regulates filamentous growth along with Mig2p in response to glucose depletion; MIG2 has a paralog, MIG3, that arose from the whole genome duplication negative regulation of transcription from RNA polymerase II promoter by glucose|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding mitochondrion|nucleus
YNL276C_d YNL276C YNL276C hom Dubious 0.210731906052203 0.41654823809988 no 1947 0.42692170200882 1407 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene MET2/YNL277W Unknown Unknown Unknown
YJR122W YJR122W IBA57 hom Verified 0.210599835195244 0.416599770461191 no 1948 0.434661359202837 1430 NA FF|FT COFACTOR METABOLISM MITOCHONDRION Mitochondrial matrix protein involved in the incorporation of iron-sulfur clusters into mitochondrial aconitase-type proteins; activates the radical-SAM family members Bio2p and Lip5p; interacts with Ccr4p in the two-hybrid system iron-sulfur cluster assembly molecular_function mitochondrion|mitochondrial matrix
YMR087W YMR087W YMR087W hom Verified 0.210061831381315 0.416809707479889 no 1949 0.418071218676103 1398 NA FT RNA PROCESSING Putative ADP-ribose-1''-monophosphatase that converts ADP-ribose-1''-monophosphate to ADP-ribose; may have a role in tRNA splicing; contains an A1pp domain tRNA splicing, via endonucleolytic cleavage and ligation phosphatase activity cellular_component
YGR078C YGR078C PAC10 hom Verified 0.209336906041609 0.417092621547377 no 1950 0.434967497469656 1429 NA FT PROTEIN COMPLEX ORG/BIOGENESIS Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding tubulin complex assembly tubulin binding prefoldin complex|polysome|cytoplasm
YDR128W YDR128W MTC5 hom Verified 0.209314688171084 0.417101293116572 no 1951 0.408905315710993 1334 NA Subunit of the SEA (Seh1-associated) complex; SEA is a coatomer-related complex that associates dynamically with the vacuole; has N-terminal WD-40 repeats and a C-terminal RING motif; mtc5 is synthetically sick with cdc13-1; relative distribution to vacuolar membrane punctae decreases upon DNA replication stress biological_process molecular_function fungal-type vacuole membrane|Seh1-associated complex|extrinsic to fungal-type vacuolar membrane
YER178W YER178W PDA1 hom Verified 0.208842085181034 0.417285758212487 no 1952 0.428593652019521 1428 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose acetyl-CoA biosynthetic process from pyruvate pyruvate dehydrogenase (acetyl-transferring) activity mitochondrial nucleoid|mitochondrion|mitochondrial pyruvate dehydrogenase complex
YDL185W YDL185W VMA1 hom Verified 0.208728034195034 0.417330277007494 no 1953 0.453501027218369 1473 NA FF|FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM Subunit A of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease intron homing|cellular protein metabolic process|vacuolar acidification endodeoxyribonuclease activity|proton-transporting ATPase activity, rotational mechanism vacuolar proton-transporting V-type ATPase, V1 domain|fungal-type vacuole membrane
YFR046C YFR046C CNN1 hom Verified 0.20842322992975 0.417449259859671 no 1954 0.410885759046335 1343 NA FT CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME KINETOCHORE Kinetochore protein; associated with the essential kinetochore proteins Nnf1p and Spc24p; phosphorylated by Clb5-Cdk1, Mps1p, Ipl1p and to a lesser extent by Clb2-Cdk1; localizes to the lower region of the Ndc80 complex during anaphase and regulates KMN activity by inhibiting the Mtw1 and Spc105 complexes from binding to the Ndc80 complex; similar to metazoan CENP-T chromosome segregation molecular_function nucleus|kinetochore
YNR071C_p YNR071C YNR071C hom Uncharacterized 0.208336751767938 0.41748301869848 no 1955 0.419329526995614 1389 NA FT CARBOHYDRATE METABOLISM Putative aldose 1-epimerase biological_process molecular_function cellular_component
YGR122W YGR122W YGR122W hom Verified 0.208293690576418 0.417499828901316 no 1956 0.425977227358316 1402 NA FF|FT TRANSCRIPTION FROM RNA POL II Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress negative regulation of transcription from RNA polymerase II promoter|nuclear-transcribed mRNA catabolic process, non-stop decay molecular_function cytoplasm
YNL300W_p YNL300W TOS6 hom Uncharacterized 0.206356237904264 0.418256326100108 no 1957 0.422953386213356 1403 NA Glycosylphosphatidylinositol-dependent cell wall protein, expression is periodic and decreases in respone to ergosterol perturbation or upon entry into stationary phase; depletion increases resistance to lactic acid biological_process molecular_function fungal-type cell wall
YPL060W YPL060W MFM1 hom Verified 0.206183494784575 0.418323790056133 no 1958 0.428290370107941 1423 NA FT RNA PROCESSING|ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Mitochondrial inner membrane magnesium transporter, involved in maintenance of mitochondrial magnesium concentrations and membrane potential; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p mitochondrial magnesium ion transport magnesium ion transmembrane transporter activity integral to membrane|mitochondrial inner membrane
YIL089W YIL089W YIL089W hom Verified 0.205197850380591 0.418708774430014 no 1959 0.408630145763748 1339 NA FT ENDOPLASMIC RETICULUM Protein of unknown function found in the ER and vacuole lumen; overexpression of YIL089W affects endocytic protein trafficking biological_process molecular_function fungal-type vacuole lumen|integral to membrane|endoplasmic reticulum
YNL058C_p YNL058C YNL058C hom Uncharacterized 0.205091955987082 0.418750140524046 no 1960 0.399393609176925 1321 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL058C is not an essential gene biological_process molecular_function fungal-type vacuole
YGR045C_d YGR045C YGR045C hom Dubious 0.204832862790127 0.418851355274353 no 1961 0.413888047813116 1358 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR194C YDR194C MSS116 hom Verified 0.204814949667831 0.418858353233695 no 1962 0.429184053395229 1396 NA FT RNA PROCESSING|TRANSLATION MITOCHONDRION DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing RNA folding|Group I intron splicing|Group II intron splicing RNA binding|RNA strand annealing activity|ATP-dependent RNA helicase activity mitochondrion|mitochondrial matrix
YOR343C_d YOR343C YOR343C hom Dubious 0.203400476137823 0.419411013842002 no 1963 0.414429479811494 1361 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLL043W YLL043W FPS1 hom Verified 0.20336581660475 0.419424557954179 no 1964 0.411291646052133 1351 NA FT ION HOMEOSTASIS|CARBOHYDRATE METABOLISM|ION HOMEOSTASIS PLASMA MEMBRANE Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress conjugation with cellular fusion|transport|arsenite transport|glycerol transport|acetate transport|response to arsenic-containing substance glycerol transmembrane transporter activity|transporter activity integral to membrane|plasma membrane|fungal-type vacuole|cytoplasm
YER096W YER096W SHC1 hom Verified 0.202913706763788 0.419601240348527 no 1965 0.427850979642051 1394 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM Sporulation-specific activator of Chs3p (chitin synthase III); required for the synthesis of the chitosan layer of ascospores; transcriptionally induced at alkaline pH; SHC1 has a paralog, SKT5, that arose from the whole genome duplication ascospore formation|chitin biosynthetic process enzyme activator activity prospore membrane
YOR144C YOR144C ELG1 hom Verified 0.202671145932464 0.419696038661181 no 1966 0.4149636250975 1362 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS|MITOCHONDRION|CHROMOSOME Subunit of an alternative replication factor C complex important for DNA replication and genome integrity; suppresses spontaneous DNA damage; involved in homologous recombination-mediated repair and telomere homeostasis; required for PCNA (Pol30p) unloading during DNA replication negative regulation of DNA recombination|negative regulation of transposition, RNA-mediated|telomere maintenance|double-strand break repair via homologous recombination|DNA-dependent DNA replication|mitotic sister chromatid cohesion chromatin binding Elg1 RFC-like complex|mitochondrion|nucleus|cytoplasm
YNL255C YNL255C GIS2 hom Verified 0.201787847305611 0.420041291284352 no 1967 0.415635834875704 1364 NA FT TRANSLATION RIBOSOME Translational activator for mRNAs with internal ribosome entry sites; associates with polysomes and binds to a specific subset of mRNAs; localizes to RNA processing bodies (P bodies) and to stress granules; may have a role in translation regulation under stress conditions; ortholog of human ZNF9/CNBP, a gene involved in myotonic dystrophy type 2 positive regulation of translation mRNA binding|translation regulator activity|single-stranded DNA binding polysomal ribosome|cytoplasm
YGL203C YGL203C KEX1 hom Verified 0.20156519945025 0.420128326790685 no 1968 0.423703835940519 1410 NA FT PROTEOLYSIS GOLGI APPARATUS Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins protein processing serine-type carboxypeptidase activity trans-Golgi network
YGR225W YGR225W AMA1 hom Verified 0.20128096263321 0.420239443778244 no 1969 0.419494584024968 1405 NA FT CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION NUCLEUS UBIQUITIN LIGASE COMPLEX Activator of meiotic anaphase promoting complex (APC/C); Cdc20p family member; required for initiation of spore wall assembly; required for Clb1p degradation during meiosis ascospore wall assembly|positive regulation of protein catabolic process|ascospore formation|meiosis I enzyme activator activity anaphase-promoting complex
YGR238C YGR238C KEL2 hom Verified 0.200290436236705 0.420626720892571 no 1970 0.407566250172498 1344 NA FT CELL CYCLE SITE OF POLARIZED GROWTH Protein that functions in a complex with Kel1p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate conjugation with cellular fusion|negative regulation of exit from mitosis molecular_function mating projection tip|cellular bud neck|cellular bud tip
YFR017C YFR017C IGD1 hom Verified 0.200247551195965 0.420643489871651 no 1971 0.433602453822985 1408 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Cytoplasmic protein that inhibits Gdb1p glycogen debranching activity; required for normal intracellular accumulation of glycogen; phosphorylated in vivo; expression increases during wine fermentation; protein abundance increases in response to DNA replication stress; IGD1 has a paralog, YOL024W, that arose from the whole genome duplication negative regulation of glycogen catabolic process enzyme inhibitor activity cytoplasm
YGR291C_d YGR291C YGR291C hom Dubious 0.200237779352118 0.420647310894231 no 1972 0.422597080343167 1377 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR371W YLR371W ROM2 hom Verified 0.200221446790646 0.420653697329612 no 1973 0.472073912730074 1556 NA FF|FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|CELL WALL ORG/BIOGENESIS|NUCLEOTIDE METABOLISM SITE OF POLARIZED GROWTH GDP/GTP exchange factor (GEF) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEF; Rom2p localization to the bud surface is dependent on Ack1p regulation of fungal-type cell wall organization|positive regulation of endocytosis|establishment of cell polarity|small GTPase mediated signal transduction|negative regulation of cAMP-mediated signaling|activation of Rho GTPase activity phosphatidylinositol-4,5-bisphosphate binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity incipient cellular bud site|mating projection tip|cellular bud tip
YPL032C YPL032C SVL3 hom Verified 0.199974352536861 0.420750319839698 no 1974 0.445891879929311 1494 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS SITE OF POLARIZED GROWTH Protein of unknown function; mutant phenotype suggests a potential role in vacuolar function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; relocalizes from bud neck to cytoplasm upon DNA replication stress endocytosis molecular_function cellular bud|cellular bud neck|cytoplasm
YLR328W YLR328W NMA1 hom Verified 0.199732133034359 0.420845040785403 no 1975 0.440673917681226 1444 NA FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM NUCLEUS Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways; NMA1 has a paralog, NMA2, that arose from the whole genome duplication NAD biosynthetic process nicotinamide-nucleotide adenylyltransferase activity nucleus|cytoplasm
YJL208C YJL208C NUC1 hom Verified 0.199597554786988 0.420897670150504 no 1976 0.425145503757925 1390 NA FT NUCLEUS|MITOCHONDRION Major mitochondrial nuclease, has RNAse and DNA endo- and exonucleolytic activities; has roles in mitochondrial recombination, apoptosis and maintenance of polyploidy DNA catabolic process|RNA catabolic process|apoptotic process|DNA recombination ribonuclease activity|endodeoxyribonuclease activity|exodeoxyribonuclease activity mitochondrion|mitochondrial inner membrane|nucleus
YAR015W YAR015W ADE1 hom Verified 0.199486532212404 0.420941088689166 no 1977 0.418050606325143 1345 NA FT NUCLEOTIDE METABOLISM NUCLEUS N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase, required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine; protein abundance increases in response to DNA replication stress purine nucleotide biosynthetic process|'de novo' IMP biosynthetic process phosphoribosylaminoimidazolesuccinocarboxamide synthase activity nucleus|cytoplasm
YIL087C YIL087C AIM19 hom Verified 0.199153291774819 0.421071417622729 no 1978 0.415951167491599 1395 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth biological_process molecular_function mitochondrion
YMR254C_d YMR254C YMR254C hom Dubious 0.19914104964312 0.421076205633749 no 1979 0.422252385474235 1394 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YAL055W YAL055W PEX22 hom Verified 0.198834592795682 0.421196067545002 no 1980 0.429168520427014 1424 NA FT PROTEIN LOCALIZATION|SIGNALING|PEROXISOME ORGANIZATION Putative peroxisomal membrane protein required for import of peroxisomal proteins, functionally complements a Pichia pastoris pex22 mutation protein import into peroxisome matrix, receptor recycling|protein targeting to peroxisome protein anchor integral to peroxisomal membrane
YGL136C YGL136C MRM2 hom Verified 0.198621795941946 0.421279301301247 no 1981 0.413922572609819 1348 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS MITOCHONDRION Mitochondrial 2' O-ribose methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ rRNA methylation rRNA (uridine-2'-O-)-methyltransferase activity mitochondrion
YNL271C YNL271C BNI1 hom Verified 0.198568985722657 0.421299958133434 no 1982 0.444463906947809 1461 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1 barbed-end actin filament capping|actin nucleation|actin filament bundle assembly involved in cytokinetic actomyosin contractile ring assembly|establishment of mitotic spindle orientation|formin-nucleated actin cable assembly profilin binding incipient cellular bud site|actin filament|polarisome|plasma membrane|cellular bud neck|mating projection tip|cellular bud tip
YKL046C YKL046C DCW1 hom Verified 0.198428862082671 0.42135476884987 no 1983 0.391930738726257 1306 NA FT CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM PLASMA MEMBRANE Putative mannosidase, GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p fungal-type cell wall biogenesis|budding cell bud growth mannosidase activity anchored to plasma membrane
YJR128W_d YJR128W YJR128W hom Dubious 0.198329739772018 0.421393542420361 no 1984 0.415083462441694 1391 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSF2 Unknown Unknown Unknown
YKR095W YKR095W MLP1 hom Verified 0.198167712646489 0.421456924042625 no 1985 0.425654691896095 1374 NA FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs protein localization to nuclear pore|poly(A)+ mRNA export from nucleus|protein import into nucleus|transcriptional activation by promoter-terminator looping|nuclear retention of unspliced pre-mRNA at the site of transcription|telomere tethering at nuclear periphery ribonucleoprotein complex binding nucleoplasm|nuclear envelope|integral to membrane|ribonucleoprotein complex|spindle pole body
YOR099W YOR099W KTR1 hom Verified 0.197200853867343 0.421835181223158 no 1986 0.416451987515255 1389 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family; relocalizes from vacuole to cytoplasm upon DNA replication stress N-glycan processing|cell wall mannoprotein biosynthetic process|protein O-linked glycosylation alpha-1,2-mannosyltransferase activity Golgi apparatus
YBR200W-A_p YBR200W-A YBR200W-A hom Uncharacterized 0.196969145511156 0.421925841537391 no 1987 0.429114984510212 1437 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YDR540C YDR540C IRC4 hom Verified 0.196369796372542 0.422160367503037 no 1988 0.43732667754095 1458 NA FF|FT NUCLEUS Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus mitotic recombination molecular_function nucleus|cytoplasm
YLR035C YLR035C MLH2 hom Verified 0.195493447169225 0.422503333559406 no 1989 0.440139078980439 1440 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS Protein involved in the mismatch repair of certain frameshift intermediates and involved in meiotic recombination; forms a complex with Mlh1p mismatch repair|reciprocal meiotic recombination molecular_function nucleus
YAL022C YAL022C FUN26 hom Verified 0.195450246785993 0.422520241886221 no 1990 0.425026567073049 1377 NA Vacuolar membrane transporter with broad nucleoside selectivity; may regulate balance of nicotinamide riboside (NmR) levels between cytosol and vacuole, contributing to salvage of NmR for use in cytosolic NAD+ synthesis nucleoside transport|nicotinamide riboside transport|transmembrane transport nicotinamide riboside transporter activity|nucleoside transmembrane transporter activity fungal-type vacuole membrane|integral to membrane|intracellular|membrane
YJL053W YJL053W PEP8 hom Verified 0.195418272820946 0.422532756363685 no 1991 0.435923765415372 1456 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress protein retention in Golgi apparatus|retrograde transport, endosome to Golgi protein transporter activity endosome|retromer complex, inner shell|retromer complex
YLR361C-A_p YLR361C-A YLR361C-A hom Uncharacterized 0.194423284302361 0.422922229763623 no 1992 0.43435679899316 1437 NA Putative protein of unknown function biological_process molecular_function cellular_component
YOR234C YOR234C RPL33B hom Verified 0.194236392096002 0.422995394344528 no 1993 0.405406882998355 1334 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L33B; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33B has a paralog, RPL33A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YOR376W-A_p YOR376W-A YOR376W-A hom Uncharacterized 0.193952392434211 0.423106579646247 no 1994 0.422971070893764 1371 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YIL173W YIL173W VTH1 hom Verified 0.193874103879339 0.423137230536715 no 1995 0.416861304119268 1370 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT GOLGI APPARATUS Putative membrane glycoprotein with strong similarity to Vth2p and Pep1p/Vps10p, may be involved in vacuolar protein sorting Golgi to vacuole transport signal sequence binding endosome|integral to membrane
YOR245C YOR245C DGA1 hom Verified 0.193870585692552 0.423138607959165 no 1996 0.433627642716689 1435 NA FT LIPID METABOLISM|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Diacylglycerol acyltransferase, catalyzes the terminal step of triacylglycerol (TAG) formation, acylates diacylglycerol using acyl-CoA as an acyl donor, localized to lipid particles lipid storage|triglyceride biosynthetic process diacylglycerol O-acyltransferase activity integral to membrane|lipid particle
YHR132C YHR132C ECM14 hom Verified 0.193514040285169 0.423278205658157 no 1997 0.415455572301731 1374 NA FT CELL WALL ORG/BIOGENESIS|PROTEOLYSIS Putative metalloprotease with similarity to the zinc carboxypeptidase family, required for normal cell wall assembly fungal-type cell wall organization|proteolysis metalloendopeptidase activity fungal-type vacuole
YDL192W YDL192W ARF1 hom Verified 0.192560075154787 0.423651757538186 no 1998 0.4366621774951 1426 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|RESPONSE TO NUTRIENT LEVELS GOLGI APPARATUS ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication ER to Golgi vesicle-mediated transport|Golgi to plasma membrane transport|intra-Golgi vesicle-mediated transport|macroautophagy GTPase activity cytosol|Golgi-associated vesicle
YGR144W YGR144W THI4 hom Verified 0.192018064005226 0.42386402784279 no 1999 0.436962804108404 1454 NA FT MITOCHONDRION ORGANIZATION NUCLEUS Thiazole synthase, abundant protein involved in the formation of the thiazole moiety of thiamine during thiamine biosynthesis; acts more as a co-substrate rather than an enzyme by providing the sulphur source for thiazole formation; undergoes a single turnover only; required for mitochondrial genome stability in response to DNA damaging agents thiamine biosynthetic process|mitochondrial genome maintenance|thiazole biosynthetic process ferrous iron binding cytosol
YGL236C YGL236C MTO1 hom Verified 0.1918945222226 0.423912414169928 no 2000 0.434200234875668 1411 NA FT RNA PROCESSING|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants mitochondrial tRNA wobble uridine modification molecular_function mitochondrion
YLR091W YLR091W GEP5 hom Verified 0.191793802520314 0.423951862858697 no 2001 0.4398409495853 1444 NA FT MITOCHONDRION ORGANIZATION MITOCHONDRION Protein of unknown function, required for mitochondrial genome maintenance; detected in highly purified mitochondria in high-throughput studies; null mutant has decreased levels of cardiolipin and phosphatidylethanolamine mitochondrial genome maintenance molecular_function mitochondrion
YER098W YER098W UBP9 hom Verified 0.190216574966576 0.424569711646598 no 2002 0.432667319794536 1416 NA FT PROTEOLYSIS Ubiquitin-specific protease that cleaves ubiquitin-protein fusions; UBP9 has a paralog, UBP13, that arose from the whole genome duplication protein deubiquitination ubiquitin-specific protease activity cytoplasm
YNL301C YNL301C RPL18B hom Verified 0.189774800216999 0.424742801771864 no 2003 0.415289550575953 1374 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L18B; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18B has a paralog, RPL18A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YGL235W_p YGL235W YGL235W hom Uncharacterized 0.189076737166194 0.425016336835112 no 2004 0.412087871712462 1321 NA Putative protein of unknown function; potential Cdc28p substrate; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2 biological_process molecular_function cellular_component
YGR250C YGR250C YGR250C hom Verified 0.188964203868502 0.425060436238532 no 2005 0.426383865545057 1418 NA Putative RNA binding protein; localizes to stress granules induced by glucose deprivation; interacts with Rbg1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress biological_process RNA binding cytoplasmic stress granule|cytoplasm
YHR193C YHR193C EGD2 hom Verified 0.188281518748954 0.425327986083118 no 2006 0.431697612374884 1391 NA FT PROTEIN LOCALIZATION NUCLEUS Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes 'de novo' cotranslational protein folding unfolded protein binding|phosphatidic acid binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4-phosphate binding nascent polypeptide-associated complex
YNL117W YNL117W MLS1 hom Verified 0.188021839595233 0.425429765488782 no 2007 0.432295700105796 1439 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM Malate synthase, enzyme of the glyoxylate cycle; involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth on oleic acid, otherwise cytosolic glyoxylate cycle malate synthase activity peroxisomal matrix|cytoplasm
YNL170W_d YNL170W YNL170W hom Dubious 0.187996584107894 0.425439664463494 no 2008 0.415339226212339 1382 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR273C YLR273C PIG1 hom Verified 0.187900436079785 0.425477350442233 no 2009 0.405788265817047 1315 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Putative targeting subunit for the type-1 protein phosphatase Glc7p that tethers it to the Gsy2p glycogen synthase regulation of glycogen biosynthetic process protein phosphatase type 1 regulator activity protein phosphatase type 1 complex
YIR036C_p YIR036C IRC24 hom Uncharacterized 0.187554227870314 0.425613055120585 no 2010 0.42692446820767 1409 NA FT OXIDATION-REDUCTION PROCESS Putative benzil reductase;(GFP)-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS; sequence similarity with short-chain dehydrogenase/reductases; null mutant has increased spontaneous Rad52p foci biological_process molecular_function integral to membrane|cytoplasm
YGL232W YGL232W TAN1 hom Verified 0.187484038423146 0.425640568646314 no 2011 0.430824358723575 1425 NA FT RNA PROCESSING NUCLEUS Putative tRNA acetyltransferase; RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA; protein abundance increases in response to DNA replication stress tRNA modification RNA binding nucleus|cytoplasm
YNL055C YNL055C POR1 hom Verified 0.187211264373266 0.425747496643979 no 2012 0.439329667667223 1469 NA FT ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS MITOCHONDRION Mitochondrial porin (voltage-dependent anion channel); outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated; protein abundance increases in response to DNA replication stress; POR1 has a paralog, POR2, that arose from the whole genome duplication DNA transport|mitochondrion organization|apoptotic process|ion transport|cell redox homeostasis voltage-gated anion channel activity mitochondrial outer membrane|mitochondrion|integral to mitochondrial outer membrane
YGL175C YGL175C SAE2 hom Verified 0.18715193945185 0.425770752860378 no 2013 0.407342015713217 1326 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS Endonuclease that processes hairpin DNA structures with the MRX complex; involved in meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents DNA double-strand break processing|DNA catabolic process, endonucleolytic|meiotic DNA double-strand break formation|meiotic DNA double-strand break processing|gene conversion at mating-type locus, DNA double-strand break processing double-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity nucleus|cytoplasm
YMR190C YMR190C SGS1 hom Verified 0.187128127852076 0.42578008742016 no 2014 0.398324127922716 1315 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Nucleolar DNA helicase of the RecQ family; involved in genome integrity maintenance; regulates chromosome synapsis and meiotic joint molecule/crossover formation; potential role as repressor of a subset of rapamycin responsive genes; rapidly lost in response to rapamycin in Rrd1p-dependent manner; similar to human BLM and WRN proteins implicated in Bloom and Werner syndromes; forms nuclear foci upon DNA replication stress DNA double-strand break processing|meiotic DNA double-strand break processing|telomeric 3' overhang formation|meiotic chromosome segregation|DNA unwinding involved in replication|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint|telomere maintenance via recombination|replicative cell aging|DNA duplex unwinding|response to DNA damage stimulus|negative regulation of meiotic joint molecule formation|chromosome organization|regulation of reciprocal meiotic recombination|gene conversion at mating-type locus, DNA double-strand break processing|mitotic sister chromatid segregation ATP-dependent DNA helicase activity RecQ helicase-Topo III complex|nucleolus
YOR166C YOR166C SWT1 hom Verified 0.186514840772215 0.426020520900915 no 2015 0.42088208493688 1387 NA FT NUCLEUS RNA endoribonuclease involved in perinuclear mRNP quality control via the turnover of aberrant, unprocessed pre-mRNAs; interacts with subunits of THO/TREX, TREX-2, and RNA polymerase II; contains a PIN (PilT N terminus) domain nuclear mRNA surveillance of mRNP export|transcription, DNA-dependent endoribonuclease activity nucleus|cytoplasm
YDL174C YDL174C DLD1 hom Verified 0.186484102326995 0.426032572346264 no 2016 0.419541187822515 1383 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane cellular carbohydrate metabolic process|aerobic respiration D-lactate dehydrogenase (cytochrome) activity mitochondrion|mitochondrial inner membrane
YAL002W YAL002W VPS8 hom Verified 0.186305134563441 0.426102740579202 no 2017 0.421771653297589 1387 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT GOLGI APPARATUS Membrane-binding component of the CORVET complex; involved in endosomal vesicle tethering and fusion in the endosome to vacuole protein targeting pathway; interacts with Vps21p; contains RING finger motif late endosome to vacuole transport via multivesicular body sorting pathway|protein targeting to vacuole GTPase binding|protein anchor late endosome|membrane|CORVET complex
YHR160C YHR160C PEX18 hom Verified 0.186255833687466 0.426122070478942 no 2018 0.435886737277224 1427 NA FT PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex21p protein import into peroxisome matrix protein binding cytosol|peroxisome
YIL119C YIL119C RPI1 hom Verified 0.186072690978851 0.426193878671828 no 2019 0.408317539168856 1340 NA FT SIGNALING NUCLEUS Transcription factor with allelic differences between S288C and Sigma1278b; mediates fermentation stress tolerance by modulating cell wall integrity; overexpression suppresses heat shock sensitivity of wild-type RAS2 overexpression and also suppresses cell lysis defect of mpk1 mutation; allele from S288c can confer fMAPK pathway independent transcription of FLO11; S288C and Sigma1278b alleles differ in number of tandem repeats within ORF fungal-type cell wall biogenesis|Ras protein signal transduction|positive regulation of transcription from RNA polymerase II promoter small GTPase regulator activity nucleus
YLR211C_p YLR211C YLR211C hom Uncharacterized 0.1852896885043 0.426500912688933 no 2020 0.422406592966849 1405 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR211C is not an essential gene; ORF contains an intron biological_process molecular_function cytoplasm
YGR038W YGR038W ORM1 hom Verified 0.185247955974518 0.426517278265088 no 2021 0.43888803054599 1453 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Evolutionarily conserved protein, similar to Orm2p, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control cellular sphingolipid homeostasis|negative regulation of sphingolipid biosynthetic process|response to unfolded protein molecular_function integral to membrane|endoplasmic reticulum|SPOTS complex
YNL162W-A_p YNL162W-A YNL162W-A hom Uncharacterized 0.184957290994341 0.426631267191378 no 2022 0.421590061676269 1363 NA FT NUCLEUS Putative protein of unknown function; identified by homology biological_process molecular_function nucleus|cytoplasm
YGL057C YGL057C GEP7 hom Verified 0.184923052561421 0.426644694744726 no 2023 0.437519048590559 1460 NA FT MITOCHONDRION Protein of unknown function; null mutant exhibits a respiratory growth defect and synthetic interactions with prohibitin (phb1) and gem1; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YBR056W YBR056W YBR056W hom Verified 0.184015550785358 0.427000627739158 no 2024 0.40988193471674 1378 NA FT CARBOHYDRATE METABOLISM Putative glycoside hydrolase of the mitochondrial intermembrane space biological_process molecular_function cytoplasm
YDR438W YDR438W THI74 hom Verified 0.183939579258945 0.42703042737615 no 2025 0.431084314235058 1414 NA FT MITOCHONDRION Mitochondrial transporter repressible by thiamine; THI74 has a paralog, YML018C, that arose from the whole genome duplication biological_process molecular_function mitochondrion|integral to membrane
YOR100C YOR100C CRC1 hom Verified 0.183466821843626 0.427215874615531 no 2026 0.419711929128341 1401 NA FT KETONE METABOLISM|LIPID METABOLISM MITOCHONDRION Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation fatty acid metabolic process carnitine:acyl carnitine antiporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YIL037C YIL037C PRM2 hom Verified 0.182547580021291 0.42757650906469 no 2027 0.431004294003716 1433 NA Pheromone-regulated protein, predicted to have 4 transmembrane segments and a coiled coil domain; regulated by Ste12p; required for efficient nuclear fusion karyogamy involved in conjugation with cellular fusion molecular_function integral to membrane
YKL073W YKL073W LHS1 hom Verified 0.181501751079733 0.427986879408163 no 2028 0.43819696343788 1455 NA FT PROTEIN LOCALIZATION|NUCLEOTIDE METABOLISM ENDOPLASMIC RETICULUM Molecular chaperone of the endoplasmic reticulum lumen, involved in polypeptide translocation and folding; nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; regulated by the unfolded protein response pathway posttranslational protein targeting to membrane, translocation|response to unfolded protein unfolded protein binding|adenyl-nucleotide exchange factor activity|ATP binding endoplasmic reticulum lumen
YNL206C YNL206C RTT106 hom Verified 0.180845252233858 0.428244521264373 no 2029 0.432760415431819 1428 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Histone chaperone, involved in regulation of chromatin structure in both transcribed and silenced chromosomal regions; affects transcriptional elongation; has a role in regulation of Ty1 transposition DNA replication-independent nucleosome assembly|negative regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|DNA replication-dependent nucleosome assembly|heterochromatin assembly involved in chromatin silencing double-stranded DNA binding|histone binding nucleus
YPR018W YPR018W RLF2 hom Verified 0.180676374450625 0.428310802014298 no 2030 0.418239833371949 1370 NA FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1); chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription DNA replication-dependent nucleosome assembly histone binding chromosome, centromeric region|nucleus|CAF-1 complex
YOR059C YOR059C YOR059C hom Verified 0.180595667067977 0.428342478569834 no 2031 0.423501793392561 1435 NA FT LIPID METABOLISM Lipid particle protein of unknown function; contains a putative lipase serine active site; induced by transcription factor Rpn4p; protein abundance increases in response to DNA replication stress biological_process molecular_function lipid particle
YKL025C YKL025C PAN3 hom Verified 0.180486317920705 0.428385397366911 no 2032 0.452931320031704 1496 NA FT RNA PROCESSING|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes DNA repair|mRNA 3'-end processing|postreplication repair poly(A)-specific ribonuclease activity PAN complex|cytoplasm
YOR307C YOR307C SLY41 hom Verified 0.180421057669628 0.428411011975542 no 2033 0.442451543081144 1461 NA FT VESICLE-MEDIATED TRANSPORT ENDOPLASMIC RETICULUM Protein involved in ER-to-Golgi transport ER to Golgi vesicle-mediated transport molecular_function integral to membrane|endoplasmic reticulum
YIL117C YIL117C PRM5 hom Verified 0.18002582042595 0.42856614879256 no 2034 0.415326104790391 1383 NA Pheromone-regulated protein, predicted to have 1 transmembrane segment; induced during cell integrity signaling biological_process molecular_function integral to membrane
YLR108C YLR108C YLR108C hom Verified 0.179787691420542 0.428659623492467 no 2035 0.441926806127209 1462 NA FT NUCLEUS Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene; protein abundance increases in response to DNA replication stress; YLR108C has a paralog, YDR132C, that arose from the whole genome duplication biological_process molecular_function nucleus
YGL043W YGL043W DST1 hom Verified 0.179584435663633 0.428739412280737 no 2036 0.431717194424791 1414 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION NUCLEUS General transcription elongation factor TFIIS, enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites; maintains RNAPII elongation activity on ribosomal protein genes during conditions of transcriptional stress transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|mRNA cleavage|maintenance of transcriptional fidelity during DNA-dependent transcription elongation from RNA polymerase II promoter|tRNA transcription from RNA polymerase III promoter|regulation of mRNA 3'-end processing|positive regulation of transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|transcription antitermination|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter RNA polymerase II regulatory region DNA binding|RNA polymerase II core binding|core RNA polymerase II recruiting transcription factor activity nucleus
YFR009W YFR009W GCN20 hom Verified 0.179567243678495 0.428746161190806 no 2037 0.442925277728483 1466 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|NUCLEOTIDE METABOLISM RIBOSOME Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA regulation of translational elongation ATPase activity cytosol|cytosolic ribosome
YIL098C YIL098C FMC1 hom Verified 0.179199096622228 0.428890686518193 no 2038 0.439587293124335 1467 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial matrix protein, required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase; null mutant temperature sensitive growth on glycerol is suppressed by multicopy expression of Odc1p mitochondrial proton-transporting ATP synthase complex assembly molecular_function mitochondrion|mitochondrial matrix
YOR205C YOR205C GEP3 hom Verified 0.17881940323335 0.42903975463494 no 2039 0.413615845127729 1379 NA FT MITOCHONDRION Protein required for mitochondrial ribosome small subunit biogenesis; null mutant is defective in respiration and in maturation of 15S rRNA; protein is localized to the mitochondrial inner membrane; null mutant interacts synthetically with prohibitin (phb1) maturation of SSU-rRNA molecular_function mitochondrion|mitochondrial inner membrane
YKL130C YKL130C SHE2 hom Verified 0.178452512128152 0.429183806174135 no 2040 0.414982109319235 1354 NA FT RNA LOCALIZATION NUCLEUS|SITE OF POLARIZED GROWTH RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud mating type switching|intracellular mRNA localization mRNA binding cellular bud tip|cytoplasm
YLR331C_d YLR331C JIP3 hom Dubious 0.178092844259617 0.4293250308271 no 2041 0.428648276002148 1420 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2 Unknown Unknown Unknown
YDL239C YDL239C ADY3 hom Verified 0.177816397745873 0.429433584518483 no 2042 0.435188060194882 1410 NA FT CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|MITOCHONDRION ORGANIZATION NUCLEUS|CYTOSKELETON Protein required for spore wall formation; thought to mediate assembly of a Don1p-containing structure at the leading edge of the prospore membrane via interaction with spindle pole body components; potentially phosphorylated by Cdc28p; ADY3 has a paralog, CNM67, that arose from the whole genome duplication mitochondrion inheritance|ascospore wall assembly|sporulation resulting in formation of a cellular spore molecular_function spindle pole body|prospore membrane
YNL001W YNL001W DOM34 hom Verified 0.177212560023615 0.429670715166583 no 2043 0.442195608108418 1458 NA FT CELL CYCLE|TRANSLATION|CELL DIVISION Protein that facilitates ribosomal subunit dissociation; acts when translation is stalled, with binding partner Hbs1p; required for RNA cleavage in no-go decay, but reports conflict on endonuclease activity; Pelota ortholog; protein abundance increases in response to DNA replication stress; DOM34 has a paralog, YCL001W-B, that arose from the whole genome duplication nuclear-transcribed mRNA catabolic process, no-go decay|ribosome disassembly|nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay|nonfunctional rRNA decay ribosome binding|endoribonuclease activity cytoplasm
YCR021C YCR021C HSP30 hom Verified 0.17698447714832 0.42976029126925 no 2044 0.424241904303512 1413 NA FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS PLASMA MEMBRANE Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase negative regulation of ATPase activity|response to stress molecular_function integral to membrane|plasma membrane
YAL036C YAL036C RBG1 hom Verified 0.176082261120993 0.430114658378745 no 2045 0.429960807291963 1396 NA FT TRANSLATION RIBOSOME Member of the DRG family of GTP-binding proteins; associates with translating ribosomes; interacts with Tma46p, Ygr250cp, Gir2p and Yap1p via two-hybrid cytoplasmic translation GTP binding polysomal ribosome|polysome|cytoplasm
YBR292C_d YBR292C YBR292C hom Dubious 0.175332652865651 0.430409127937751 no 2046 0.428117651639555 1434 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene Unknown Unknown Unknown
YBL068W YBL068W PRS4 hom Verified 0.174939705303923 0.430563505498053 no 2047 0.404627882449565 1313 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication fungal-type cell wall organization|5-phosphoribose 1-diphosphate biosynthetic process ribose phosphate diphosphokinase activity cytoplasm
YPR129W YPR129W SCD6 hom Verified 0.174713974724514 0.430652193216174 no 2048 0.441754206536825 1456 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION Repressor of translation initiation; binds eIF4G through its RGG domain and inhibits recruitment of the preinitiation complex; also contains an Lsm domain; may have a role in RNA processing; overproduction suppresses null mutation in clathrin heavy chain gene CHC1; forms cytoplasmic foci upon DNA replication stress stress granule assembly|negative regulation of translational initiation|cytoplasmic mRNA processing body assembly mRNA binding|RNA binding|eukaryotic initiation factor 4G binding cytoplasmic mRNA processing body|cytoplasmic stress granule|cytoplasm
YIR033W YIR033W MGA2 hom Verified 0.174215974242492 0.430847865940167 no 2049 0.352953463367643 1154 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|GENE SILENCING ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting positive regulation of transcription from RNA polymerase II promoter in response to hypoxia|cellular response to cold|positive regulation of unsaturated fatty acid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|mRNA stabilization|positive regulation of transcription from RNA polymerase II promoter in response to cobalt ion|positive regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette molecular_function integral to endoplasmic reticulum membrane|nucleus
YJR048W YJR048W CYC1 hom Verified 0.173996144133428 0.430934246273067 no 2050 0.414256440713377 1375 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; CYC1 has a paralog, CYC7, that arose from the whole genome duplication mitochondrial electron transport, cytochrome c to oxygen|mitochondrial electron transport, ubiquinol to cytochrome c electron carrier activity mitochondrion|mitochondrial intermembrane space
YNL014W YNL014W HEF3 hom Verified 0.1737139711604 0.431045128535045 no 2051 0.437086469229521 1452 NA FT TRANSLATION|NUCLEOTIDE METABOLISM RIBOSOME Translational elongation factor EF-3; member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells; HEF3 has a paralog, YEF3, that arose from the whole genome duplication translational elongation ATPase activity|translation elongation factor activity cytosolic ribosome
YLR187W YLR187W SKG3 hom Verified 0.173245102706175 0.431229386384204 no 2052 0.433202726932587 1425 NA FT SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate; similar to Skg4p; relocalizes from bud neck to cytoplasm upon DNA replication stress; SKG3 has a paralog, CAF120, that arose from the whole genome duplication biological_process molecular_function cellular bud|cellular bud neck|cytoplasm
YDL096C_d YDL096C OPI6 hom Dubious 0.171646521470373 0.431857715671363 no 2053 0.429815265347649 1407 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PMT1/YDL095W; YDL096C is not essential Unknown Unknown Unknown
YMR244C-A YMR244C-A COA6 hom Verified 0.171145355137603 0.432054736848344 no 2054 0.431338731952943 1411 NA FT NUCLEUS|MITOCHONDRION Protein involved in cytochrome c oxidase assembly; also required for efficient formation of respiratory supercomplexes comprised of Complexes III and IV; localizes to the mitochondrial intermembrane space; has a human homolog; transcription is induced in response to the DNA-damaging agent MMS; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus|cytoplasm
YHR140W_p YHR140W YHR140W hom Uncharacterized 0.170184155180624 0.432432656140194 no 2055 0.421214529823291 1383 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Putative integral membrane protein of unknown function biological_process molecular_function integral to membrane
YMR228W YMR228W MTF1 hom Verified 0.169973035876541 0.432515671155318 no 2056 0.417699445923174 1373 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation transcription initiation from mitochondrial promoter mitochondrial RNA polymerase binding promoter specificity activity mitochondrion|mitochondrial DNA-directed RNA polymerase complex|mitochondrial matrix|mitochondrial intermembrane space
YOR374W YOR374W ALD4 hom Verified 0.169080555228184 0.432866639698281 no 2057 0.434683512180922 1430 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM MITOCHONDRION Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed NADPH regeneration|ethanol metabolic process|pyruvate metabolic process|acetate biosynthetic process aldehyde dehydrogenase [NAD(P)+] activity|aldehyde dehydrogenase (NAD) activity mitochondrial nucleoid|mitochondrion
YNL296W_d YNL296W YNL296W hom Dubious 0.16894271277887 0.432920851051806 no 2058 0.474864155180108 1571 NA Dubious open reading frame unlikely to encode a functional protein; deletion adversely affects sporulation; deletion mutant exhibits synthetic phenotype under expression of mutant huntingtin fragment, but gene does not have human ortholog Unknown Unknown Unknown
YOR233W YOR233W KIN4 hom Verified 0.168503236069395 0.433093699028444 no 2059 0.408849379421272 1356 NA FT CELL CYCLE|PROTEIN PHOSPHORYLATION SITE OF POLARIZED GROWTH|CYTOSKELETON Serine/threonine protein kinase; inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck; KIN4 has a paralog, FRK1, that arose from the whole genome duplication mitotic cell cycle spindle orientation checkpoint|protein phosphorylation protein serine/threonine kinase activity|protein kinase activity cell cortex|spindle pole body|cellular bud neck
YIR020C_p YIR020C YIR020C hom Uncharacterized 0.168236375447964 0.433198662644164 no 2060 0.414387770015937 1368 NA Protein of unknown function; mRNA identified as translated by ribosome profiling data biological_process molecular_function cellular_component
YOR052C YOR052C YOR052C hom Verified 0.168137126266038 0.433237701277407 no 2061 0.436809063968498 1433 NA FT NUCLEUS Nuclear protein of unknown function; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner and by weak acid; transcriptionally regulated by Rpn4p along with proteasome subunit genes; putative ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus
YLR358C_p YLR358C YLR358C hom Uncharacterized 0.167922736460111 0.433322031500335 no 2062 0.389544284396925 1270 NA Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps ORF RSC2/YLR357W biological_process molecular_function cellular_component
YNL144C_p YNL144C YNL144C hom Uncharacterized 0.167770384019036 0.433381961173454 no 2063 0.437360952122528 1434 NA FT MITOCHONDRION Putative protein of unknown function; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; contains a PH domain and binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study biological_process molecular_function mitochondrion
YMR137C YMR137C PSO2 hom Verified 0.167311153042038 0.433562614487952 no 2064 0.42869691893539 1421 NA FT RESPONSE TO DNA DAMAGE NUCLEUS Nuclease required for DNA single- and double-strand break repair; acts at a post-incision step in repair of breaks that result from interstrand cross-links produced by a variety of mono- and bi-functional psoralen derivatives; induced by UV-irradiation; forms nuclear foci upon DNA replication stress DNA repair|double-strand break repair damaged DNA binding|5'-3' exonuclease activity nucleus
YHL007C YHL007C STE20 hom Verified 0.167200278423562 0.433606232676359 no 2065 0.440018239986028 1442 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|SIGNALING|CELL DIVISION|PROTEIN PHOSPHORYLATION NUCLEUS|SITE OF POLARIZED GROWTH Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p negative regulation of gene expression|osmosensory signaling pathway via Sho1 osmosensor|activation of MAPKKK activity|vacuole inheritance|protein phosphorylation|cellular bud site selection|cellular response to heat|regulation of exit from mitosis|pheromone-dependent signal transduction involved in conjugation with cellular fusion|signal transduction involved in filamentous growth|pseudohyphal growth|sterol import|stress granule assembly|invasive growth in response to glucose limitation|positive regulation of apoptotic process histone serine kinase activity|MAP kinase kinase kinase kinase activity|protein kinase activity incipient cellular bud site|plasma membrane|nucleus|mating projection tip
YKL138C YKL138C MRPL31 hom Verified 0.167079456268359 0.433653765156569 no 2066 0.423579171899547 1397 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrial large ribosomal subunit
YNL333W YNL333W SNZ2 hom Verified 0.166769027675076 0.433775894846607 no 2067 0.430482354841062 1439 NA FT COFACTOR METABOLISM Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO2; interacts with Thi11p pyridoxine metabolic process|thiamine biosynthetic process protein binding cellular_component
YPR052C YPR052C NHP6A hom Verified 0.16590737974868 0.434114919892684 no 2068 0.430569683253648 1423 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME High-mobility group (HMG) protein, binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to chromosomes; functionally redundant with Nhp6Bp; homologous to mammalian HMGB1 and HMGB2; NHP6A has a paralog, NHP6B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress mismatch repair|DNA replication-independent nucleosome organization|RNA polymerase II transcriptional preinitiation complex assembly|RNA polymerase III transcriptional preinitiation complex assembly|chromatin remodeling nucleosome binding|sequence-specific DNA binding|DNA binding, bending MutSalpha complex|nucleus
YOL152W YOL152W FRE7 hom Verified 0.16579444393091 0.434159359355499 no 2069 0.43881308958026 1478 NA FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY PLASMA MEMBRANE Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels iron ion transport|copper ion import ferric-chelate reductase activity integral to membrane|plasma membrane
YHR139C-A_d YHR139C-A YHR139C-A hom Dubious 0.165766236456582 0.434170458931351 no 2070 0.43357649426781 1470 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOR293W YOR293W RPS10A hom Verified 0.165520004289361 0.43426735292217 no 2071 0.381138370577657 1258 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication cytoplasmic translation|rRNA export from nucleus structural constituent of ribosome cytosolic small ribosomal subunit
YBL029C-A YBL029C-A YBL029C-A hom Verified 0.165247782887737 0.43437447844521 no 2072 0.444438867406799 1468 NA FT PLASMA MEMBRANE Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; protein abundance increases in response to DNA replication stress; has potential orthologs in Saccharomyces species and in Yarrowia lipolytica biological_process molecular_function plasma membrane
YLR285C-A_p YLR285C-A YLR285C-A hom Uncharacterized 0.164676851310779 0.434599169089714 no 2073 0.427180236262661 1404 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YCR028C YCR028C FEN2 hom Verified 0.164649640785594 0.434609878344793 no 2074 0.438166073270548 1435 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION PLASMA MEMBRANE Plasma membrane H+-pantothenate symporter; confers sensitivity to the antifungal agent fenpropimorph; relocalizes from vacuole to cytoplasm upon DNA replication stress pantothenate transmembrane transport|endocytosis pantothenate transmembrane transporter activity integral to membrane|plasma membrane
YCR101C_p YCR101C YCR101C hom Uncharacterized 0.164624488980304 0.434619777391498 no 2075 0.43517430397923 1453 NA Putative protein of unknown function; localizes to the membrane fraction; YCR101C is not an essential gene biological_process molecular_function integral to membrane|membrane
YML050W YML050W AIM32 hom Verified 0.164484938726637 0.434674701210543 no 2076 0.445946932323926 1473 NA Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss biological_process molecular_function cellular_component
YGR210C_p YGR210C YGR210C hom Uncharacterized 0.164481071024177 0.434676223468588 no 2077 0.426672989591228 1388 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm biological_process molecular_function cytoplasm
YCR026C YCR026C NPP1 hom Verified 0.163916130877286 0.434898584127736 no 2078 0.460147254077441 1512 NA FT NUCLEOTIDE METABOLISM|RESPONSE TO NUTRIENT LEVELS Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; NPP1 has a paralog, NPP2, that arose from the whole genome duplication cellular response to phosphate starvation|phosphate-containing compound metabolic process|nucleoside triphosphate metabolic process nucleotide diphosphatase activity|nucleoside-triphosphate diphosphatase activity|nucleoside-triphosphatase activity|phosphodiesterase I activity cellular_component
YIL084C YIL084C SDS3 hom Verified 0.163278587593842 0.435149546137628 no 2079 0.443019529511609 1473 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Component of the Rpd3p/Sin3p deacetylase complex required for its structural integrity and catalytic activity, involved in transcriptional silencing and required for sporulation; cells defective in SDS3 display pleiotropic phenotypes positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of chromatin silencing at telomere|chromatin silencing|negative regulation of chromatin silencing at rDNA|positive regulation of transcription from RNA polymerase II promoter|histone deacetylation histone deacetylase activity Rpd3L-Expanded complex|Rpd3L complex
YLR082C YLR082C SRL2 hom Verified 0.162387340779302 0.435500419562327 no 2080 0.43105063510666 1421 NA FT NUCLEUS Protein of unknown function; overexpression suppresses the lethality caused by a rad53 null mutation nucleobase-containing compound metabolic process molecular_function nucleus|cytoplasm
YLR053C_p YLR053C YLR053C hom Uncharacterized 0.162087292771698 0.435618556386174 no 2081 0.424329594463723 1383 NA Putative protein of unknown function biological_process molecular_function cellular_component
YIL123W YIL123W SIM1 hom Verified 0.161737977212928 0.43575609838338 no 2082 0.438314874827952 1450 NA FT CELL WALL ORG/BIOGENESIS Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated fungal-type cell wall organization molecular_function fungal-type cell wall
YGL215W YGL215W CLG1 hom Verified 0.16126745635387 0.435941376899574 no 2083 0.446934364594215 1464 NA FT CELL CYCLE|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS Cyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2 positive regulation of macroautophagy cyclin-dependent protein kinase regulator activity cyclin-dependent protein kinase holoenzyme complex
YGL051W YGL051W MST27 hom Verified 0.161171743717273 0.435979067695333 no 2084 0.431110626664048 1424 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS|PLASMA MEMBRANE Putative integral membrane protein, involved in vesicle formation; forms complex with Mst28p; member of DUP240 gene family; binds COPI and COPII vesicles vesicle organization molecular_function integral to membrane|Golgi apparatus|endoplasmic reticulum|plasma membrane
YJL176C YJL176C SWI3 hom Verified 0.160843806737526 0.436108210804854 no 2085 0.443576990804692 1497 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS NUCLEUS RSC COMPLEX Subunit of the SWI/SNF chromatin remodeling complex; SWI/SNF regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; relocates to the cytosol under hypoxic conditions cellular alcohol catabolic process|ATP-dependent chromatin remodeling|positive regulation of mating type switching|sucrose catabolic process|carbon catabolite activation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter histone binding|DNA binding SWI/SNF complex|nucleus
YLR388W YLR388W RPS29A hom Verified 0.160754912338975 0.436143219007018 no 2086 0.452774989530822 1526 NA FT TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29A has a paralog, RPS29B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic small ribosomal subunit
YBL042C YBL042C FUI1 hom Verified 0.160719235927567 0.43615726915585 no 2087 0.474496359319622 1584 NA FF|FT PLASMA MEMBRANE High affinity uridine permease, localizes to the plasma membrane; also mediates low but significant transport of the cytotoxic nucleoside analog 5-fluorouridine; not involved in uracil transport; relative distribution to the vacuole increases upon DNA replication stress uridine transport|transmembrane transport uridine transmembrane transporter activity integral to membrane|plasma membrane
YMR307W YMR307W GAS1 hom Verified 0.160715229838877 0.436158846845971 no 2088 0.448514742798735 1478 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|GENE SILENCING NUCLEUS|MITOCHONDRION|PLASMA MEMBRANE Beta-1,3-glucanosyltransferase, required for cell wall assembly and also has a role in transcriptional silencing; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor; also found at the nuclear periphery fungal-type cell wall organization|chromatin silencing|filamentous growth 1,3-beta-glucanosyltransferase activity mitochondrion|membrane raft|primary cell septum|nuclear periphery|integral to membrane|fungal-type cell wall|plasma membrane|cellular bud scar|ER to Golgi transport vesicle
YOR106W YOR106W VAM3 hom Verified 0.160394338183112 0.436285224678207 no 2089 0.451382800605842 1499 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|RESPONSE TO NUTRIENT LEVELS Syntaxin-like vacuolar t-SNARE that functions with Vam7p in vacuolar protein trafficking; mediates docking/fusion of late transport intermediates with the vacuole; has an acidic di-leucine sorting signal and C-terminal transmembrane region autophagic vacuole fusion|vesicle fusion with vacuole|piecemeal microautophagy of nucleus|vacuole fusion, non-autophagic|vesicle docking|vesicle fusion protein homodimerization activity|SNAP receptor activity SNARE complex|fungal-type vacuole membrane
YBR248C YBR248C HIS7 hom Verified 0.160318988545521 0.436314900821064 no 2090 0.430516360148868 1441 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM Imidazole glycerol phosphate synthase (glutamine amidotransferase:cyclase), catalyzes the fifth step of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR), a purine precursor purine nucleoside monophosphate biosynthetic process|histidine biosynthetic process imidazoleglycerol-phosphate synthase activity intracellular
YCR095W-A_p YCR095W-A YCR095W-A hom Uncharacterized 0.160232972755756 0.436348778221994 no 2091 0.438776641631227 1431 NA Putative protein of unknown function biological_process molecular_function cellular_component
YLL042C YLL042C ATG10 hom Verified 0.160118770346291 0.436393757671463 no 2092 0.428926256838415 1409 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Conserved E2-like conjugating enzyme that mediates formation of the Atg12p-Atg5p conjugate, which is a critical step in autophagy piecemeal microautophagy of nucleus|cellular protein modification process|mitochondrion degradation|macroautophagy|CVT pathway Atg12 ligase activity cellular_component
YDR001C YDR001C NTH1 hom Verified 0.1600934940004 0.436403713055294 no 2093 0.436467469565622 1444 NA FT CARBOHYDRATE METABOLISM Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p; NTH1 has a paralog, NTH2, that arose from the whole genome duplication trehalose catabolic process|response to stress alpha,alpha-trehalase activity cytosol|cytoplasm
YHR025W YHR025W THR1 hom Verified 0.159226733876509 0.436745120980893 no 2094 0.44853137916364 1497 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway threonine biosynthetic process|methionine metabolic process|isoleucine metabolic process|homoserine metabolic process homoserine kinase activity cellular_component
YOR266W YOR266W PNT1 hom Verified 0.159134910074727 0.436781292199703 no 2095 0.431389386403081 1419 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial integral inner membrane protein involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p; deletion mutant sensitive to the anti-Pneumocystis carinii drug pentamidine protein insertion into mitochondrial membrane from inner side molecular_function mitochondrion|integral to mitochondrial inner membrane
YOL118C_d YOL118C YOL118C hom Dubious 0.158000887926575 0.43722804952035 no 2096 0.455390152942485 1502 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR190W YLR190W MMR1 hom Verified 0.157868957974072 0.437280029615776 no 2097 0.397227911530494 1297 NA FT CELL CYCLE|CELL DIVISION|MITOCHONDRION ORGANIZATION MITOCHONDRION|SITE OF POLARIZED GROWTH Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p mitochondrion inheritance molecular_function mitochondrial outer membrane|incipient cellular bud site|mitochondrion|cellular bud|cellular bud neck
YMR086W YMR086W SEG1 hom Verified 0.157517846890718 0.437418371840884 no 2098 0.435094479889827 1440 NA Component of eisosome required for proper eisosome assembly; precedes Pil1p/Lsp1p during eisosome formation and controls eisosome length and shape; Seg1p-GFP diffusely distributed and forms heterogeneous patches at the plasma membrane in small buds, also found in medium and large buds; may interact with ribosomes, based on co-purification experiments; expression is repressed by cAMP; similar to A. gossypii SEG gene and to S. pombe Sle1p, important for generating eisosomes biological_process molecular_function eisosome|ribosome|cytoplasm
YGL079W_p YGL079W KXD1 hom Uncharacterized 0.157109137265992 0.437579418258647 no 2099 0.435272373756642 1434 NA Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; GFP-fusion protein localizes to the endosome biological_process molecular_function endosome
YDL134C YDL134C PPH21 hom Verified 0.157040780242161 0.437606354415792 no 2100 0.428989759204774 1428 NA FT CELL CYCLE|TRANSLATION|CELL DIVISION|CYTOSKELETON ORGANIZATION Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; forms nuclear foci upon DNA replication stress; PPH21 has a paralog, PPH22, that arose from the whole genome duplication actin filament organization|budding cell bud growth|protein dephosphorylation|G1/S transition of mitotic cell cycle|mitotic cell cycle spindle assembly checkpoint|regulation of translation protein serine/threonine phosphatase activity protein phosphatase type 2A complex
YDR018C_p YDR018C YDR018C hom Uncharacterized 0.156966757859644 0.437635523339581 no 2101 0.43514121189947 1456 NA FT LIPID METABOLISM Probable membrane protein with three predicted transmembrane domains; similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase; YDR018C has a paralog, CST26, that arose from the whole genome duplication phospholipid biosynthetic process transferase activity, transferring acyl groups integral to membrane
YML058W YML058W SML1 hom Verified 0.156554797405351 0.437797864792186 no 2102 0.398840706941871 1309 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION NUCLEUS Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase mitochondrion organization|response to DNA damage stimulus enzyme inhibitor activity nucleus|cytoplasm
YDR428C YDR428C BNA7 hom Verified 0.156358476787501 0.437875232637085 no 2103 0.435324384848419 1430 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM Formylkynurenine formamidase, involved in the de novo biosynthesis of NAD from tryptophan via kynurenine NAD biosynthetic process arylformamidase activity cellular_component
YBR048W YBR048W RPS11B hom Verified 0.156302923412969 0.437897126055982 no 2104 0.441412812180852 1453 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11B has a paralog, RPS11A, that arose from the whole genome duplication cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal small subunit assembly structural constituent of ribosome cytosolic small ribosomal subunit|90S preribosome
YDR432W YDR432W NPL3 hom Verified 0.154401497965297 0.438646586308839 no 2105 0.456316134355813 1506 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION NUCLEUS RNA-binding protein; promotes elongation, regulates termination, and carries poly(A) mRNA from nucleus to cytoplasm; has a role in repressing translation initiation by binding eIF4G; required for pre-mRNA splicing; dissociation from mRNAs promoted by Mtr10p; phosphorylated by Sky1p in the cytoplasm; protein abundance increases in response to DNA replication stress translational termination|mRNA export from nucleus|negative regulation of translation|mRNA splicing, via spliceosome|Unknown|positive regulation of transcription elongation from RNA polymerase II promoter mRNA binding|RNA polymerase II core binding|eukaryotic initiation factor 4G binding|poly(A) RNA binding nucleus|cytoplasm
YLR037C YLR037C PAU23 hom Verified 0.15378196173292 0.438890828545598 no 2106 0.437154065282831 1413 NA FT CELL WALL ORG/BIOGENESIS Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth biological_process molecular_function fungal-type cell wall
YPR065W YPR065W ROX1 hom Verified 0.153611151285252 0.438958171925116 no 2107 0.440334192323054 1452 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS|CHROMOSOME Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter in response to stress RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|DNA binding, bending|sequence-specific DNA binding|RNA polymerase II transcription factor recruiting transcription factor activity nuclear chromatin
YDR059C YDR059C UBC5 hom Verified 0.153500307755064 0.439001873815271 no 2108 0.442124699660454 1459 NA Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived, abnormal, or excess proteins, including histone H3; central component of the cellular stress response; expression is heat inducible; protein abundance increases in response to DNA replication stress; UBC5 has a paralog, UBC4, that arose from the whole genome duplication protein polyubiquitination|response to stress ubiquitin-protein ligase activity proteasome complex
YKR067W YKR067W GPT2 hom Verified 0.153281903141547 0.439087985612263 no 2109 0.443103178637543 1464 NA FT LIPID METABOLISM ENDOPLASMIC RETICULUM Glycerol-3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis; the most conserved motifs and functionally relevant residues are oriented towards the ER lumen phospholipid biosynthetic process glycerol-3-phosphate O-acyltransferase activity|glycerone-phosphate O-acyltransferase