strainid	orf	gene	zyg	qualifier	SGTC_2242|6630449.score	SGTC_2242|6630449.expt.zyg.pval	SGTC_2242|6630449.expt.zyg.significant	SGTC_2242|6630449.expt.zyg.rank	strain.pval	strain.rank	clearance	Fclass	Fterms.BP	Fterms.CC	Fterms.complex	description	GO_process	GO_function	GO_component
YJL004C	YJL004C	SYS1	hom	Verified	17.9027443312447	5.61258151895994e-72	yes	1	9.44627463747053e-42	2	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation	vesicle organization|Golgi to plasma membrane protein transport|Golgi to endosome transport	molecular_function	trans-Golgi network|integral to membrane|integral to Golgi membrane
YPL051W	YPL051W	ARL3	hom	Verified	16.2373325481751	1.37303986400261e-59	yes	2	3.43707012374081e-44	2	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor	intracellular protein transport|Golgi to plasma membrane protein transport|protein localization to organelle	GTPase activity	Golgi apparatus|nuclear outer membrane-endoplasmic reticulum membrane network
YJL124C	YJL124C	LSM1	hom	Verified	14.0805970129895	2.49928589957873e-45	yes	3	2.56887748064637e-34	6	NA	FF|FT	RNA PROCESSING	NUCLEUS		Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; forms cytoplasmic foci upon DNA replication stress	deadenylation-dependent decapping of nuclear-transcribed mRNA|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	RNA binding|RNA cap binding	mRNA cap binding complex|cytoplasmic mRNA processing body|cytoplasm
YML071C	YML071C	COG8	hom	Verified	12.8026129652459	7.92629481785239e-38	yes	4	9.06199482450372e-12	9	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments	intra-Golgi vesicle-mediated transport|CVT pathway	molecular_function	Golgi transport complex
YGL095C	YGL095C	VPS45	hom	Verified	11.6077049551747	1.88293972202353e-31	yes	5	4.06535300382171e-15	5	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment	vacuole inheritance|CVT pathway|positive regulation of SNARE complex assembly|Golgi vesicle fusion to target membrane|Golgi to vacuole transport|vacuole organization|vacuolar acidification|protein targeting to vacuole|Golgi to endosome transport	unfolded protein binding|SNARE binding	cytosol|SNARE complex|Golgi membrane|extrinsic to membrane
YBR164C	YBR164C	ARL1	hom	Verified	11.5677125166694	3.00313475093098e-31	yes	6	1.31911275220684e-17	8	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|VACUOLAR TRANSPORT	GOLGI APPARATUS		Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor	Golgi to plasma membrane protein transport|vesicle-mediated transport|protein targeting to vacuole	GTPase activity	trans-Golgi network|cytosol|Golgi apparatus
YKR001C	YKR001C	VPS1	hom	Verified	9.92355316536398	1.6441851737079e-23	yes	7	3.87766980572171e-12	1	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION|VACUOLAR TRANSPORT|PEROXISOME ORGANIZATION	MITOCHONDRION|CYTOSKELETON		Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, endocytosis, late Golgi-retention of some proteins, regulation of peroxisome biogenesis	vacuolar transport|peroxisome fission|endocytosis|actin cytoskeleton organization|protein retention in Golgi apparatus|peroxisome organization|lipid tube assembly|protein targeting to vacuole	GTPase activity	mitochondrial outer membrane|fungal-type vacuole membrane|peroxisome|actin cortical patch
YOR070C	YOR070C	GYP1	hom	Verified	8.13018106763159	2.14324832418966e-16	yes	8	1.52586065036725e-08	44	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM	MITOCHONDRION|GOLGI APPARATUS		Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion	vesicle-mediated transport	Rab GTPase activator activity	mitochondrion|Golgi apparatus
YGL005C	YGL005C	COG7	hom	Verified	7.97561322205294	7.58130416954816e-16	yes	9	2.69911384233381e-05	37	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|MITOCHONDRION|GOLGI APPARATUS		Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments	intra-Golgi vesicle-mediated transport|CVT pathway	molecular_function	mitochondrion|Golgi transport complex
YCR006C_d	YCR006C	YCR006C	hom	Dubious	7.95552699837689	8.91853090207638e-16	yes	10	5.98710594932321e-15	2	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YJL204C	YJL204C	RCY1	hom	Verified	7.38986726278386	7.34877313595563e-14	yes	11	4.4231260027473e-09	159	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	GOLGI APPARATUS|SITE OF POLARIZED GROWTH		F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth	early endosome to Golgi transport|endocytosis	SNARE binding	endosome|Golgi apparatus|site of polarized growth
YCR094W	YCR094W	CDC50	hom	Verified	6.81483667881746	4.71854574431396e-12	yes	12	1.24312238152258e-08	76	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	GOLGI APPARATUS		Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Lem3p; CDC50 has a paralog, YNR048W, that arose from the whole genome duplication	intracellular protein transport|phospholipid translocation|endocytosis|actin cortical patch localization	phospholipid-translocating ATPase activity	trans-Golgi network|late endosome membrane
YDR162C	YDR162C	NBP2	hom	Verified	6.79521368249261	5.4076053015273e-12	yes	13	2.13545142603672e-07	23	NA	FF|FT	PROTEIN PHOSPHORYLATION	NUCLEUS		Protein involved in the HOG (high osmolarity glycerol) pathway; negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex; interacts with Bck1p and down regulates the cell wall integrity pathway; found in the nucleus and cytoplasm, contains an SH3 domain and a Ptc1p binding domain (PBM)	negative regulation of protein kinase activity|response to heat|hyperosmotic response	molecular_function	nucleus|cytoplasm
YOL018C	YOL018C	TLG2	hom	Verified	6.47730126575829	4.66888189094769e-11	yes	14	4.96223624421614e-05	28	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	GOLGI APPARATUS		Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16)	inositolphosphoceramide metabolic process|Golgi to vacuole transport|endocytosis|mannosyl-inositol phosphorylceramide metabolic process|protein exit from endoplasmic reticulum|vesicle fusion|CVT pathway	SNAP receptor activity	SNARE complex|trans-Golgi network|integral to endosome membrane
YLR372W	YLR372W	SUR4	hom	Verified	6.28101196517056	1.68188124721301e-10	yes	15	8.83365250165613e-05	65	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|KETONE METABOLISM|LIPID METABOLISM	ENDOPLASMIC RETICULUM		Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis	post-Golgi vesicle-mediated transport|fatty acid elongation|fatty acid biosynthetic process|sphingolipid biosynthetic process	fatty acid elongase activity	integral to membrane|endoplasmic reticulum
YNL041C	YNL041C	COG6	hom	Verified	6.22712677424883	2.37533352934564e-10	yes	16	0.000584060324996642	57	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments	intra-Golgi vesicle-mediated transport|CVT pathway	molecular_function	Golgi transport complex
YNR051C	YNR051C	BRE5	hom	Verified	6.21312161795294	2.59711077138717e-10	yes	17	4.18838308135646e-10	9	NA	FT	VESICLE-MEDIATED TRANSPORT			Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A	protein deubiquitination|ribophagy|regulation of ER to Golgi vesicle-mediated transport|Unknown	molecular_function	cytoplasm
YLR262C	YLR262C	YPT6	hom	Verified	6.01534062287921	8.97544191722927e-10	yes	18	6.06960035000382e-05	14	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING	GOLGI APPARATUS|PLASMA MEMBRANE		Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6	intracellular protein transport|retrograde transport, endosome to Golgi	GTPase activity	Golgi apparatus
YFR043C	YFR043C	IRC6	hom	Verified	5.63531887035388	8.73673572701024e-09	yes	19	1.52735520191574e-08	5	NA					Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci	biological_process	molecular_function	cellular_component
YNL051W	YNL051W	COG5	hom	Verified	5.53842275983818	1.52603899429101e-08	yes	20	7.77368716370906e-05	24	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments	intra-Golgi vesicle-mediated transport|CVT pathway	molecular_function	Golgi transport complex
YOR089C	YOR089C	VPS21	hom	Verified	5.48369406411845	2.08267434933616e-08	yes	21	2.15728132845758e-05	49	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|VACUOLAR TRANSPORT	MITOCHONDRION		Rab family GTPase; required for endocytic transport and for sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog; protein abundance increases in response to DNA replication stress; VPS21 has a paralog, YPT53, that arose from the whole genome duplication	endocytosis|vacuole inheritance|protein targeting to vacuole	GTP binding|GTPase activity	mitochondrial outer membrane|late endosome|mitochondrion
YEL036C	YEL036C	ANP1	hom	Verified	5.29390153487634	5.98669596936753e-08	yes	22	1.83445141421338e-06	13	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol	protein N-linked glycosylation	alpha-1,6-mannosyltransferase activity|mannosyltransferase activity	alpha-1,6-mannosyltransferase complex|Golgi cis cisterna
YEL039C	YEL039C	CYC7	hom	Verified	5.19081622253559	1.04687102349873e-07	yes	23	1.0378267626224e-06	6	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; protein abundance increases in response to DNA replication stress; CYC7 has a paralog, CYC1, that arose from the whole genome duplication	mitochondrial electron transport, cytochrome c to oxygen|mitochondrial electron transport, ubiquinol to cytochrome c	electron carrier activity	mitochondrion|mitochondrial intermembrane space
YDR323C	YDR323C	PEP7	hom	Verified	5.06375759209929	2.05536146773032e-07	yes	24	8.81332552019289e-05	68	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT			Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance	Golgi to vacuole transport|vacuole inheritance|vesicle fusion|vesicle docking involved in exocytosis|Golgi to endosome transport	phosphatidylinositol-3-phosphate binding	external side of endosome membrane|cytoplasm
YOR036W	YOR036W	PEP12	hom	Verified	5.0564262304649	2.13593002015232e-07	yes	25	1.20108547181564e-05	49	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	GOLGI APPARATUS		Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin	Golgi to vacuole transport|vacuole inheritance	SNAP receptor activity	endosome|Golgi apparatus
YKR019C	YKR019C	IRS4	hom	Verified	5.05591310545256	2.14168172184124e-07	yes	26	0.0108899189876212	185	NA	FF|FT	LIPID METABOLISM|SIGNALING|CELL WALL ORG/BIOGENESIS|RESPONSE TO NUTRIENT LEVELS|GENE SILENCING	MITOCHONDRION		EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication	autophagy|fungal-type cell wall organization|chromatin silencing at rDNA|inositol lipid-mediated signaling|CVT pathway|cellular response to starvation	molecular_function	mitochondrion|pre-autophagosomal structure
YLR261C_d	YLR261C	VPS63	hom	Dubious	4.95511908856282	3.61430010471659e-07	yes	27	0.000385444206131001	34	NA	FF				Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect	Unknown	Unknown	Unknown
YDR320C	YDR320C	SWA2	hom	Verified	4.94761965207887	3.75632619655164e-07	yes	28	6.57576434366105e-05	31	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|NUCLEOTIDE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles	positive regulation of ATPase activity|endoplasmic reticulum inheritance|clathrin coat disassembly	ubiquitin binding|clathrin binding	endoplasmic reticulum membrane
YMR012W	YMR012W	CLU1	hom	Verified	4.76895067648718	9.25939952699327e-07	yes	29	4.02064565909349e-07	1	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION			eIF3 component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation, can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant	translational initiation|mitochondrion organization	molecular_function	eukaryotic translation initiation factor 3 complex|cytoplasm
YDR389W	YDR389W	SAC7	hom	Verified	4.76879346317775	9.2666273291025e-07	yes	30	4.40227991690788e-05	40	NA	FF|FT	CELL CYCLE|SIGNALING|CYTOSKELETON ORGANIZATION	CYTOSKELETON		GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate	actin filament reorganization involved in cell cycle|small GTPase mediated signal transduction	Rho GTPase activator activity	intracellular
YEL022W	YEL022W	GEA2	hom	Verified	4.75677714313356	9.83540600023733e-07	yes	31	3.55701061462079e-05	21	NA	FT	VESICLE-MEDIATED TRANSPORT|SIGNALING|CYTOSKELETON ORGANIZATION|RESPONSE TO NUTRIENT LEVELS	GOLGI APPARATUS		Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA2 has a paralog, GEA1, that arose from the whole genome duplication	retrograde vesicle-mediated transport, Golgi to ER|secretory granule organization|ER to Golgi vesicle-mediated transport|macroautophagy|intra-Golgi vesicle-mediated transport|actin cytoskeleton organization	ARF guanyl-nucleotide exchange factor activity	integral to membrane|Golgi cis cisterna|extrinsic to membrane
YNL147W	YNL147W	LSM7	hom	Verified	4.65828049756757	1.59430776270018e-06	yes	32	4.92189615904471e-06	23	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress	nuclear-transcribed mRNA catabolic process|mRNA splicing, via spliceosome|maturation of SSU-rRNA	RNA binding	U6 snRNP|nucleolus|small nucleolar ribonucleoprotein complex|U4/U6 x U5 tri-snRNP complex|cytoplasm
YLR148W	YLR148W	PEP3	hom	Verified	4.62788834557349	1.84706538795471e-06	yes	33	0.00027431178751498	43	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT			Component of CORVET tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis	regulation of SNARE complex assembly|regulation of vacuole fusion, non-autophagic|vacuole fusion, non-autophagic|late endosome to vacuole transport|vesicle docking involved in exocytosis|Golgi to endosome transport	phosphatidylinositol binding|protein binding, bridging	fungal-type vacuole membrane|HOPS complex|proteasome storage granule|CORVET complex|extrinsic to vacuolar membrane
YBL071W-A	YBL071W-A	KTI11	hom	Verified	4.47110649597697	3.89079671091542e-06	yes	34	3.7367505732861e-05	8	NA	FT	RNA PROCESSING	NUCLEUS		Zn-ribbon protein that co-purifies with Dph1 and Dph2 in a complex required for synthesis of diphthamide on translation factor eEF2 and with Elongator subunits Iki3p, Elp2p, and Elp3p involved in modification of wobble nucleosides in tRNAs	peptidyl-diphthamide biosynthetic process from peptidyl-histidine|tRNA wobble uridine modification	electron carrier activity|iron ion binding|zinc ion binding	nucleus|cytoplasm
YDR136C_d	YDR136C	VPS61	hom	Dubious	4.45702930031914	4.15516240903293e-06	yes	35	0.00285634365054682	45	NA	FF				Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 4% of ORF overlaps the verified gene RGP1; deletion causes a vacuolar protein sorting defect	Unknown	Unknown	Unknown
YJR060W	YJR060W	CBF1	hom	Verified	4.37949163237403	5.94782444912137e-06	yes	36	7.89491681965894e-05	43	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|CHROMOSOME SEGREGATION	NUCLEUS|MITOCHONDRION|CHROMOSOME	KINETOCHORE	Dual function helix-loop-helix protein; binds the motif CACRTG present at several sites including MET gene promoters and centromere DNA element I (CDEI); affects nucleosome positioning at this motif; associates with other transcription factors such as Met4p and Isw1p to mediate transcriptional activation or repression; associates with kinetochore proteins and required for efficient chromosome segregation; protein abundance increases in response to DNA replication stress	regulation of transcription from RNA polymerase II promoter in response to methionine|negative regulation of transcription from RNA polymerase II promoter|methionine biosynthetic process|chromosome segregation|Unknown|chromatin remodeling|negative regulation of ceramide biosynthetic process by negative regulation of transcription from RNA Polymerase II promoter	RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor binding transcription factor activity|RNA polymerase II repressing transcription factor binding|centromeric DNA binding	chromosome, centromeric region|mitochondrion|nucleus|kinetochore
YPL069C	YPL069C	BTS1	hom	Verified	4.35092611723139	6.77818645098795e-06	yes	37	0.00681886996090341	156	NA	FF|FT	PROTEIN LOCALIZATION|LIPID METABOLISM	MITOCHONDRION		Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic	terpenoid biosynthetic process	farnesyltranstransferase activity	mitochondrion
YER151C	YER151C	UBP3	hom	Verified	4.23759033028863	1.1296576586384e-05	yes	38	0.000104651723658475	38	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS			Ubiquitin-specific protease involved in transport and osmotic response; interacts with Bre5p to co-regulate anterograde and retrograde transport between the ER and Golgi; involved in transcription elongation in response to osmostress through phosphorylation at Ser695 by Hog1p; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin; also has mRNA binding activity; protein abundance increases in response to DNA replication stress	protein deubiquitination|ribophagy|regulation of ER to Golgi vesicle-mediated transport|regulation of response to osmotic stress	ubiquitin-specific protease activity|mRNA binding	cytoplasm
YOR061W	YOR061W	CKA2	hom	Verified	4.23094831115024	1.16354073659259e-05	yes	39	5.26934758173547e-05	54	NA	FF|FT	RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION	NUCLEUS		Alpha' catalytic subunit of casein kinase 2 (CK2); CK2 is a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; protein abundance increases in response to DNA replication stress; regulates Fkh1p-mediated donor preference during mating-type switching	regulation of transcription from RNA polymerase I promoter|chronological cell aging|protein phosphorylation|regulation of transcription from RNA polymerase III promoter|response to DNA damage stimulus	protein serine/threonine kinase activity	protein kinase CK2 complex|UTP-C complex
YLR396C	YLR396C	VPS33	hom	Verified	4.22214295027946	1.20995274150731e-05	yes	40	2.90119771433673e-05	4	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT			ATP-binding protein that is a subunit of the HOPS complex and of the CORVET tethering complex; essential for protein sorting, vesicle docking and fusion at the vacuole	regulation of SNARE complex assembly|endocytosis|regulation of vacuole fusion, non-autophagic|piecemeal microautophagy of nucleus|vesicle fusion with vacuole|Golgi to vacuole transport|vacuole organization|vacuole fusion, non-autophagic|vesicle docking|protein targeting to vacuole	phosphatidylinositol binding|ATP binding	cytosol|fungal-type vacuole membrane|HOPS complex|fungal-type vacuole|CORVET complex
YGL054C	YGL054C	ERV14	hom	Verified	4.17417938755803	1.49531024247394e-05	yes	41	0.00343847975037871	131	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|SIGNALING|CELL DIVISION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		COPII-coated vesicle protein; involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon; ERV14 has a paralog, ERV15, that arose from the whole genome duplication	ascospore formation|ER to Golgi vesicle-mediated transport|axial cellular bud site selection	molecular_function	integral to membrane|ER to Golgi transport vesicle|endoplasmic reticulum membrane
YDR150W	YDR150W	NUM1	hom	Verified	4.17041869449072	1.52020258491577e-05	yes	42	0.000317705636318063	32	NA	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION	MITOCHONDRION|SITE OF POLARIZED GROWTH		Protein required for nuclear migration, localizes to the mother cell cortex and the bud tip; may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex	mitochondrion inheritance|nuclear migration along microtubule|mitochondrial fission|microtubule cytoskeleton organization	tubulin binding	cell cortex|mitochondrion|cellular bud tip
YML115C	YML115C	VAN1	hom	Verified	4.07682358994174	2.28275518664082e-05	yes	43	0.000232228451202655	39	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Component of the mannan polymerase I, which contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant	protein N-linked glycosylation	alpha-1,6-mannosyltransferase activity	alpha-1,6-mannosyltransferase complex
YAL056C-A_d	YAL056C-A	YAL056C-A	hom	Dubious	4.03508864857692	2.72908430040172e-05	yes	44	5.28033960442801e-05	23	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YCR079W	YCR079W	PTC6	hom	Verified	3.89325393277704	4.94542618010606e-05	yes	45	0.00012075654361708	28	NA	FT	RESPONSE TO NUTRIENT LEVELS	MITOCHONDRION		Mitochondrial type 2C protein phosphatase (PP2C) with similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase	mitochondrion degradation|positive regulation of catalytic activity|macroautophagy|protein dephosphorylation	protein serine/threonine phosphatase activity	mitochondrion|mitochondrial matrix|mitochondrial intermembrane space
YBL051C	YBL051C	PIN4	hom	Verified	3.86309041207981	5.59807728084747e-05	yes	46	0.000214021789229751	45	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE			Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage	G2/M transition of mitotic cell cycle|DNA damage checkpoint	molecular_function	cytoplasm
YOR085W	YOR085W	OST3	hom	Verified	3.79489313109637	7.38535326773586e-05	yes	47	6.42271771528531e-05	24	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins	protein glycosylation|protein complex assembly|protein O-linked mannosylation|protein N-linked glycosylation	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	oligosaccharyltransferase complex|integral to membrane
YJL122W	YJL122W	ALB1	hom	Verified	3.78401162218339	7.71603061055882e-05	yes	48	1.61974607666512e-05	5	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS	NUCLEUS		Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p	ribosomal large subunit biogenesis	molecular_function	ribosome|nucleus|cytoplasm
YDR316W	YDR316W	OMS1	hom	Verified	3.77470624998846	8.0098160672734e-05	yes	49	0.000310749910330309	23	NA	FT		MITOCHONDRION		Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif; multicopy suppressor of respiratory defects caused by OXA1 mutations	biological_process	S-adenosylmethionine-dependent methyltransferase activity	mitochondrial envelope|mitochondrion
YJL183W	YJL183W	MNN11	hom	Verified	3.75055734662773	8.82209724196657e-05	yes	50	0.00052179347193498	42	NA	FT	CARBOHYDRATE METABOLISM	GOLGI APPARATUS		Subunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p	protein glycosylation	alpha-1,6-mannosyltransferase activity	alpha-1,6-mannosyltransferase complex
YGL257C	YGL257C	MNT2	hom	Verified	3.68431889973889	0.000114657498879089	yes	51	8.76027797837273e-05	9	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans	protein O-linked glycosylation	alpha-1,3-mannosyltransferase activity	cellular_component
YCR077C	YCR077C	PAT1	hom	Verified	3.63765133690996	0.000137567766267519	yes	52	0.000322416000732668	60	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|TRANSLATION|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS	RIBOSOME	Deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; associated with topoisomerase II; functionally linked to Pab1p; forms cytoplasmic foci upon DNA replication stress	deadenylation-dependent decapping of nuclear-transcribed mRNA|chromosome segregation|regulation of translational initiation|formation of translation preinitiation complex|negative regulation of translational initiation|cytoplasmic mRNA processing body assembly	molecular_function	cytosolic small ribosomal subunit|cytoplasmic mRNA processing body
YOR108W	YOR108W	LEU9	hom	Verified	3.61253850294105	0.000151607033351204	yes	53	0.000114651811825836	17	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Alpha-isopropylmalate synthase II (2-isopropylmalate synthase); catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant; LEU9 has a paralog, LEU4, that arose from the whole genome duplication	leucine biosynthetic process	2-isopropylmalate synthase activity	mitochondrion
YHR046C	YHR046C	INM1	hom	Verified	3.589160947708	0.000165871993891879	yes	54	0.000331121687564338	20	NA	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	NUCLEUS		Inositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate	inositol phosphate dephosphorylation	inositol monophosphate 1-phosphatase activity	nucleus|cytoplasm
YEL053C	YEL053C	MAK10	hom	Verified	3.5293978471457	0.000208253233622715	yes	55	0.000126640763558617	28	NA					Non-catalytic subunit of N-terminal acetyltransferase of the NatC type, required for replication of dsRNA virus; expression is glucose-repressible	N-terminal protein amino acid acetylation	peptide alpha-N-acetyltransferase activity	NatC complex|cytoplasm
YJR019C	YJR019C	TES1	hom	Verified	3.51698929199069	0.000218235694750339	yes	56	0.000152960014106468	13	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM	MITOCHONDRION		Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids	fatty acid beta-oxidation|fatty acid oxidation	acyl-CoA hydrolase activity	mitochondrion|peroxisome
YER119C-A_d	YER119C-A	YER119C-A	hom	Dubious	3.49505465824837	0.000236982341501994	yes	57	0.00150347682677371	72	NA	FF				Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene SCS2	Unknown	Unknown	Unknown
YDR137W	YDR137W	RGP1	hom	Verified	3.39937539276802	0.000337699736452004	yes	58	0.00961909289402313	103	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|CELL DIVISION	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p	retrograde transport, endosome to Golgi	guanyl-nucleotide exchange factor activity	Golgi apparatus|Ric1p-Rgp1p complex|Golgi membrane|guanyl-nucleotide exchange factor complex
YJR050W	YJR050W	ISY1	hom	Verified	3.38647666057089	0.000353981491081441	yes	59	0.00113819400393921	37	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING	NUCLEUS		Member of NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of spliceosome containing U2, U5, and U6 snRNAs, interacts with Prp16p to modulate splicing fidelity; isy1 syf2 cells have defective spindles	generation of catalytic spliceosome for second transesterification step|mRNA 3'-splice site recognition	first spliceosomal transesterification activity|second spliceosomal transesterification activity	post-spliceosomal complex|Prp19 complex|post-mRNA release spliceosomal complex|U2-type catalytic step 2 spliceosome|U2-type catalytic step 1 spliceosome
YDR334W	YDR334W	SWR1	hom	Verified	3.37287606037868	0.000371937141358822	yes	60	0.0019937064561194	123	NA	FF|FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A	chromatin remodeling|histone exchange	structural molecule activity	Swr1 complex|nucleus
YKR020W	YKR020W	VPS51	hom	Verified	3.35921816705165	0.000390816667637929	yes	61	0.00241537166135031	66	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL DIVISION|VACUOLAR TRANSPORT	GOLGI APPARATUS		Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; links the (VFT/GARP) complex to the SNARE Tlg1p	vesicle organization|retrograde transport, endosome to Golgi|budding cell apical bud growth|regulation of cell size|protein targeting to vacuole	protein binding	Golgi apparatus|GARP complex
YHR150W	YHR150W	PEX28	hom	Verified	3.30816449326921	0.000469548163513534	yes	62	0.000516744970226449	22	NA	FT	PEROXISOME ORGANIZATION			Peroxisomal integral membrane peroxin, involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p	peroxisome organization	molecular_function	integral to membrane|peroxisomal membrane
YDR120C	YDR120C	TRM1	hom	Verified	3.27931822422993	0.000520291117315923	yes	63	0.000929582044664205	61	NA	FT	RNA PROCESSING	ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION		tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments	tRNA methylation	tRNA (guanine-N2-)-methyltransferase activity	mitochondrion|nuclear envelope|nuclear inner membrane
YDR351W	YDR351W	SBE2	hom	Verified	3.22467889121047	0.000630570182374254	yes	64	0.000717951998328527	43	NA	FT	PROTEIN LOCALIZATION|CELL WALL ORG/BIOGENESIS	GOLGI APPARATUS		Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth	fungal-type cell wall organization	molecular_function	Golgi apparatus
YKL148C	YKL148C	SDH1	hom	Verified	3.20526426108751	0.000674692651573525	yes	65	0.00274571723637172	34	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Flavoprotein subunit of succinate dehydrogenase; couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; FAD binding to Sdh1p is required for the assembly of the succinate dehydrogenase subunits	cellular respiration|mitochondrial electron transport, succinate to ubiquinone|tricarboxylic acid cycle	succinate dehydrogenase (ubiquinone) activity|flavin adenine dinucleotide binding	mitochondrial respiratory chain complex II|mitochondrion|mitochondrial membrane
YBL052C	YBL052C	SAS3	hom	Verified	3.17815993297473	0.000741064852271337	yes	66	0.00150973957194496	48	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS	HISTONE ACETYLTRANSFERASE	Histone acetyltransferase catalytic subunit of NuA3 complex that acetylates histone H3, involved in transcriptional silencing; homolog of the mammalian MOZ proto-oncogene; mutant has aneuploidy tolerance; sas3gcn5 double mutation is lethal	histone acetylation|chromatin modification|chromatin silencing at telomere|chromatin silencing at silent mating-type cassette	histone acetyltransferase activity	NuA3 histone acetyltransferase complex
YHR154W	YHR154W	RTT107	hom	Verified	3.1732231496013	0.00075378302086361	yes	67	0.00223613966554824	73	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Protein implicated in Mms22-dependent DNA repair during S phase; involved in recruiting the SMC5/6 complex to double-strand breaks; DNA damage induces phosphorylation by Mec1p at one or more SQ/TQ motifs; interacts with Mms22p and Slx4p; has four BRCT domains; has a role in regulation of Ty1 transposition; relative distribution to nuclear foci increases upon DNA replication stress	negative regulation of transposition, RNA-mediated|double-strand break repair	molecular_function	Cul8-RING ubiquitin ligase complex|nucleus
YML020W_p	YML020W	YML020W	hom	Uncharacterized	3.14202840529838	0.000838908788247536	yes	68	0.000806669419890327	42	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YGR107W_d	YGR107W	YGR107W	hom	Dubious	3.11951418552486	0.000905747690330214	yes	69	0.000858735675343411	30	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YBL010C_p	YBL010C	YBL010C	hom	Uncharacterized	3.08667046657576	0.0010120592551467	no	70	0.000932876396251311	44	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles	biological_process	molecular_function	clathrin-coated vesicle
YMR194C-A_d	YMR194C-A	YMR194C-A	hom	Dubious	3.07826866828942	0.00104103555352715	no	71	0.000596782211337444	39	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR455C_d	YDR455C	YDR455C	hom	Dubious	3.0547312690889	0.00112631131835682	no	72	0.00490285005204385	181	NA	FF				Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W	Unknown	Unknown	Unknown
YJL092W	YJL092W	SRS2	hom	Verified	3.05048314452279	0.00114236752093142	no	73	0.0011608969886723	55	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		DNA helicase and DNA-dependent ATPase involved in DNA repair and checkpoint recovery, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability	DNA repair|double-strand break repair via nonhomologous end joining|DNA duplex unwinding	DNA helicase activity	nucleus
YPR198W	YPR198W	SGE1	hom	Verified	3.04481331703258	0.00116412389271827	no	74	0.00623236333953274	121	NA	FF|FT		PLASMA MEMBRANE		Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations	response to drug|drug transport	drug transmembrane transporter activity	integral to membrane|integral to plasma membrane
YGL060W	YGL060W	YBP2	hom	Verified	3.03496031140487	0.00120283670869255	no	75	0.00136065231466569	62	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME	KINETOCHORE	Central kinetochore associated protein; mediates mitotic progression; interacts with several central kinetochore proteins and centromeric histone Cse4p; role in resistance to oxidative stress; similar to Slk19p; YBP2 has a paralog, YBP1, that arose from the whole genome duplication	G2/M transition of mitotic cell cycle	molecular_function	condensed nuclear chromosome kinetochore|centromere-specific nucleosome|cytoplasm
YJR001W	YJR001W	AVT1	hom	Verified	3.02909465154109	0.00122643910278906	no	76	0.00463464005666039	83	NA	FT	VACUOLAR TRANSPORT			Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters	amino acid transport|vacuolar transport	transporter activity|L-glutamine transmembrane transporter activity|L-isoleucine transmembrane transporter activity|L-tyrosine transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YOR165W	YOR165W	SEY1	hom	Verified	3.0240303478594	0.00124715708098805	no	77	0.00133694760664029	49	NA	FT	MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Dynamin-like GTPase that mediates homotypic ER fusion; has a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; functional ortholog of the human atlastin ATL1, defects in which cause a form of the human disease hereditary spastic paraplegia; homolog of Arabidopsis RHD3	cellular membrane organization|endoplasmic reticulum organization|endoplasmic reticulum membrane fusion|endoplasmic reticulum inheritance	GTPase activity	integral to membrane|endoplasmic reticulum|cortical endoplasmic reticulum|cytoplasm
YNR064C	YNR064C	YNR064C	hom	Verified	3.01006388386681	0.00130596373287425	no	78	0.000971044259225448	70	NA					Epoxide hydrolase, member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides	response to toxin	epoxide hydrolase activity	cellular_component
YKL130C	YKL130C	SHE2	hom	Verified	3.00107909691176	0.00134512337127451	no	79	0.000316778839779724	15	NA	FT	RNA LOCALIZATION	NUCLEUS|SITE OF POLARIZED GROWTH		RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud	mating type switching|intracellular mRNA localization	mRNA binding	cellular bud tip|cytoplasm
YHL015W-A_p	YHL015W-A	YHL015W-A	hom	Uncharacterized	2.97408881819506	0.00146930001466162	no	80	0.000958617585182486	29	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YNL271C	YNL271C	BNI1	hom	Verified	2.97354671376769	0.00147189796853523	no	81	0.00753441309855229	105	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON		Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1	barbed-end actin filament capping|actin nucleation|actin filament bundle assembly involved in cytokinetic actomyosin contractile ring assembly|establishment of mitotic spindle orientation|formin-nucleated actin cable assembly	profilin binding	incipient cellular bud site|actin filament|polarisome|plasma membrane|cellular bud neck|mating projection tip|cellular bud tip
YLR267W_p	YLR267W	BOP2	hom	Uncharacterized	2.94831761588176	0.00159754304607241	no	82	0.000123831843968082	14	NA					Protein of unknown function	biological_process	molecular_function	cellular_component
YNL081C	YNL081C	SWS2	hom	Verified	2.94640987816218	0.0016074304289041	no	83	0.00772017806167289	101	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency	regulation of sporulation resulting in formation of a cellular spore|mitochondrial translation	structural constituent of ribosome	mitochondrial small ribosomal subunit|cytoplasm
YHR016C	YHR016C	YSC84	hom	Verified	2.91838355229301	0.00175925632633354	no	84	0.00212307212665956	53	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION	CYTOSKELETON		Actin-binding protein; involved in bundling of actin filaments and endocytosis of actin cortical patches; activity stimulated by Las17p; contains SH3 domain similar to Rvs167p; YSC84 has a paralog, LSB3, that arose from the whole genome duplication	endocytosis|actin filament organization|actin filament bundle assembly|actin cortical patch localization|actin cytoskeleton organization	actin filament binding	actin cortical patch
YJL134W	YJL134W	LCB3	hom	Verified	2.90744981437184	0.00182194403900524	no	85	0.00199389320368248	33	NA	FT	LIPID METABOLISM|SIGNALING	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Long-chain base-1-phosphate phosphatase; specific for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids; LCB3 has a paralog, YSR3, that arose from the whole genome duplication	calcium-mediated signaling|sphingolipid biosynthetic process	sphingosine-1-phosphate phosphatase activity	integral to membrane|endoplasmic reticulum
YLR351C	YLR351C	NIT3	hom	Verified	2.90200864825652	0.00185389152091515	no	86	0.00079230064358748	21	NA	FT		MITOCHONDRION		Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member	biological_process	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	mitochondrion|cytoplasm
YER031C	YER031C	YPT31	hom	Verified	2.8993985154175	0.00186939678107895	no	87	0.00941964402043792	188	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING	ENDOMEMBRANE SYSTEM|MITOCHONDRION|GOLGI APPARATUS		Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication	early endosome to Golgi transport|vesicle-mediated transport|exocytosis	GTPase activity	mitochondrial outer membrane|endosome|Golgi apparatus
YCL012C	YCL012C	YCL012C	hom	Verified	2.88979821079865	0.00192744593126715	no	88	0.00108655417671266	38	NA					Putative protein of unknown function; orthologs are present in S. bayanus, S. paradoxus and Ashbya gossypii; YCL012C is not an essential gene	biological_process	molecular_function	cellular_component
YDR108W	YDR108W	TRS85	hom	Verified	2.88104746899221	0.00198177971009165	no	89	0.00759153716283158	144	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION	GOLGI APPARATUS		Subunit of TRAPPIII (transport protein particle), a multimeric guanine nucleotide-exchange factor for Ypt1p, required for membrane expansion during autophagy and the CVT pathway; directs Ypt1p to the PAS; late post-replication meiotic role	meiosis|vesicle organization|piecemeal microautophagy of nucleus|ER to Golgi vesicle-mediated transport|peroxisome degradation|macroautophagy|protein localization to pre-autophagosomal structure|CVT pathway	molecular_function	TRAPP complex|pre-autophagosomal structure
YLL005C	YLL005C	SPO75	hom	Verified	2.86778887412675	0.00206675631963014	no	90	0.00062336074328678	33	NA	FT	CELL WALL ORG/BIOGENESIS			Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis	ascospore wall assembly|ascospore formation	molecular_function	integral to membrane
YBL008W	YBL008W	HIR1	hom	Verified	2.8431858487408	0.00223325086427004	no	91	0.0028779718106448	40	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores	DNA replication-independent nucleosome assembly|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter	nucleosome binding|transcription corepressor activity|DNA binding	chromosome, centromeric region|HIR complex|nucleus
YER048C	YER048C	CAJ1	hom	Verified	2.83606134082214	0.00228368363941448	no	92	0.00159413330906148	42	NA	FT		NUCLEUS		Nuclear type II J heat shock protein of the E. coli dnaJ family, contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly	protein folding	chaperone binding	nucleus
YOR280C	YOR280C	FSH3	hom	Verified	2.83440472189784	0.00229555730666716	no	93	0.00197060422183792	65	NA					Putative serine hydrolase; likely target of Cyc8p-Tup1p-Rfx1p transcriptional regulation; sequence is similar to S. cerevisiae Fsh1p and Fsh2p and the human candidate tumor suppressor OVCA2	biological_process	molecular_function	cellular_component
YPR070W	YPR070W	MED1	hom	Verified	2.8214177424412	0.00239059487067842	no	94	0.006166665418332	94	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RNA POL II, HOLOENZYME	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation	negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	molecular_function	core mediator complex
YKL164C	YKL164C	PIR1	hom	Verified	2.79773415260794	0.00257312253465736	no	95	0.00204748158332561	22	NA	FT	PROTEIN LOCALIZATION|CELL WALL ORG/BIOGENESIS			O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle; PIR1 has a paralog, YJL160C, that arose from the whole genome duplication	intracellular protein transport|fungal-type cell wall organization	structural constituent of cell wall	fungal-type cell wall
YER135C_d	YER135C	YER135C	hom	Dubious	2.79705175216302	0.00257856359839834	no	96	0.0052678858535752	64	NA					Dubious open reading frame unlikely to encode a protein; YER135C is not an essential gene	Unknown	Unknown	Unknown
YNL296W_d	YNL296W	YNL296W	hom	Dubious	2.79651320332338	0.00258286501161401	no	97	0.00401096467375956	76	NA					Dubious open reading frame unlikely to encode a functional protein; deletion adversely affects sporulation; deletion mutant exhibits synthetic phenotype under expression of mutant huntingtin fragment, but gene does not have human ortholog	Unknown	Unknown	Unknown
YDR456W	YDR456W	NHX1	hom	Verified	2.79225745782688	0.00261708456261533	no	98	0.00286619671206935	123	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS	GOLGI APPARATUS		Na+/H+ and K+/H+ exchanger, required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion	sodium ion transmembrane transport|potassium ion transmembrane transport|cellular monovalent inorganic cation homeostasis|vacuolar acidification	sodium:hydrogen antiporter activity|potassium:hydrogen antiporter activity	trans-Golgi network|late endosome|fungal-type vacuole membrane|integral to membrane|early endosome
YDL041W_d	YDL041W	YDL041W	hom	Dubious	2.78295204981119	0.00269333832678596	no	99	0.00791536981231469	129	NA	FF				Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIR2/YDL042C	Unknown	Unknown	Unknown
YAR003W	YAR003W	SWD1	hom	Verified	2.77402325979182	0.00276838596842317	no	100	0.00549545309429154	77	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member with similarity to mammalian Rbbp7	histone H3-K4 methylation|telomere maintenance|regulation of transcription, DNA-dependent|chromatin silencing at telomere	histone methyltransferase activity (H3-K4 specific)	Set1C/COMPASS complex
YJR005W	YJR005W	APL1	hom	Verified	2.77248965614778	0.00278146436822865	no	101	0.00327349784022345	57	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|PLASMA MEMBRANE		Beta-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport; similar to mammalian beta-chain of the clathrin associated protein complex	vesicle-mediated transport	molecular_function	AP-2 adaptor complex
YLR039C	YLR039C	RIC1	hom	Verified	2.76550077233935	0.00284177352381628	no	102	0.0280543715417845	135	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS		Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes	intracellular protein transport|retrograde transport, endosome to Golgi	guanyl-nucleotide exchange factor activity	nucleus|Ric1p-Rgp1p complex|Golgi membrane|guanyl-nucleotide exchange factor complex
YKL081W	YKL081W	TEF4	hom	Verified	2.75543774994357	0.00293068284293674	no	103	0.00392297580965549	48	NA	FT	TRANSLATION	MITOCHONDRION	RIBOSOME	Gamma subunit of translational elongation factor eEF1B, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex	translational elongation	translation elongation factor activity	mitochondrion|ribosome|eukaryotic translation elongation factor 1 complex
YPL086C	YPL086C	ELP3	hom	Verified	2.75435290956484	0.00294041587813431	no	104	0.0059836002769242	78	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|CHROMATIN ORGANIZATION	NUCLEUS		Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin	regulation of transcription from RNA polymerase II promoter|tRNA wobble uridine modification	histone acetyltransferase activity	Elongator holoenzyme complex|nucleus|cytoplasm
YMR135W-A_d	YMR135W-A	YMR135W-A	hom	Dubious	2.74053584635842	0.00306695453164471	no	105	0.000965508787465281	14	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR322W_d	YLR322W	VPS65	hom	Dubious	2.73159045631047	0.00315147180300184	no	106	0.00613252065523528	86	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 75% of ORF overlaps the verified gene SFH1; deletion causes a vacuolar protein sorting defect and blocks anaerobic growth	Unknown	Unknown	Unknown
YLR273C	YLR273C	PIG1	hom	Verified	2.72654932695391	0.00320001929193519	no	107	0.000849670783729074	34	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Putative targeting subunit for the type-1 protein phosphatase Glc7p that tethers it to the Gsy2p glycogen synthase	regulation of glycogen biosynthetic process	protein phosphatase type 1 regulator activity	protein phosphatase type 1 complex
YNL093W	YNL093W	YPT53	hom	Verified	2.72428258413197	0.00322206716146844	no	108	0.00557809708565704	106	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|VACUOLAR TRANSPORT	PLASMA MEMBRANE		Rab family GTPase; similar to Ypt51p and Ypt52p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; YPT53 has a paralog, VPS21, that arose from the whole genome duplication	endocytosis|protein targeting to vacuole	GTPase activity	late endosome
YGL012W	YGL012W	ERG4	hom	Verified	2.71725436926946	0.00329129977971708	no	109	0.0352347376017713	295	NA	FF|FT	LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	ENDOPLASMIC RETICULUM		C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol	ergosterol biosynthetic process	delta24(24-1) sterol reductase activity	integral to membrane|endoplasmic reticulum
YDR195W	YDR195W	REF2	hom	Verified	2.70262368439163	0.00343972920392727	no	110	0.00616604187562834	71	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		RNA-binding protein involved in the cleavage step of mRNA 3'-end formation prior to polyadenylation, and in snoRNA maturation; part of holo-CPF subcomplex APT, which associates with 3'-ends of snoRNA- and mRNA-encoding genes	mRNA 3'-end processing|termination of RNA polymerase II transcription, poly(A)-coupled|snoRNA 3'-end processing|Unknown	chromatin binding|RNA binding	mRNA cleavage and polyadenylation specificity factor complex|nucleus
YLL052C	YLL052C	AQY2	hom	Verified	2.69670168231633	0.00350149879642188	no	111	0.00538385081793736	47	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains	water transport	water channel activity	plasma membrane|endoplasmic reticulum membrane
YDR069C	YDR069C	DOA4	hom	Verified	2.68128758601484	0.00366697291350316	no	112	0.00643484691394444	114	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|PROTEOLYSIS	MITOCHONDRION		Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole	protein deubiquitination|endocytosis|regulation of DNA replication|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|free ubiquitin chain depolymerization|ubiquitin homeostasis|ubiquitin-dependent protein catabolic process	endopeptidase activity|ubiquitin-specific protease activity|ubiquitin thiolesterase activity	endosome|proteasome complex|mitochondrion
YFL028C	YFL028C	CAF16	hom	Verified	2.67618718590053	0.00372325213720371	no	113	0.00251417880498443	42	NA	FT	TRANSCRIPTION FROM RNA POL II|NUCLEOTIDE METABOLISM	NUCLEUS		Part of evolutionarily-conserved CCR4-NOT regulatory complex; contains single ABC-type ATPase domain but no transmembrane domain; interacts with several subunits of Mediator	regulation of transcription from RNA polymerase II promoter	ATPase activity	CCR4-NOT complex|cytoplasm
YKR013W	YKR013W	PRY2	hom	Verified	2.66240980141336	0.00387916798230236	no	114	0.00893443881626265	83	NA					Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY1; may be involved in detoxification of hydrophobic compounds; PRY2 has a paralog, PRY1, that arose from the whole genome duplication	biological_process	molecular_function	extracellular region|fungal-type vacuole
YDR495C	YDR495C	VPS3	hom	Verified	2.65016066739696	0.00402267504097755	no	115	0.0116729512850182	152	NA	FF|FT	PROTEIN LOCALIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT			Component of CORVET tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase	vacuole inheritance|vacuolar acidification|protein targeting to vacuole	molecular_function	CORVET complex|cytoplasm
YOR286W	YOR286W	RDL2	hom	Verified	2.64743219414097	0.00405528114634218	no	116	0.00272362709946009	45	NA	FT		MITOCHONDRION		Protein with rhodanese activity; contains a rhodanese-like domain similar to Rdl1p, Uba4p, Tum1p, and Ych1p; overexpression causes a cell cycle delay; null mutant displays elevated frequency of mitochondrial genome loss	biological_process	thiosulfate sulfurtransferase activity	mitochondrion
YLR121C	YLR121C	YPS3	hom	Verified	2.64654820575321	0.0040658957104402	no	117	0.00412650353270406	53	NA	FT	CELL WALL ORG/BIOGENESIS|PROTEOLYSIS	PLASMA MEMBRANE		Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor	fungal-type cell wall organization|cellular protein metabolic process	aspartic-type endopeptidase activity	anchored to plasma membrane|plasma membrane
YMR306W	YMR306W	FKS3	hom	Verified	2.63830699207877	0.00416605576892091	no	118	0.00628162347885901	77	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	MITOCHONDRION|PLASMA MEMBRANE		Protein involved in spore wall assembly, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	ascospore wall assembly	1,3-beta-D-glucan synthase activity	mitochondrion|integral to membrane
YEL016C	YEL016C	NPP2	hom	Verified	2.63428412346775	0.00421574503109749	no	119	0.00480348064093908	53	NA	FT	NUCLEOTIDE METABOLISM			Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp1p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; NPP2 has a paralog, NPP1, that arose from the whole genome duplication	nucleoside triphosphate metabolic process	nucleotide diphosphatase activity|nucleoside-triphosphate diphosphatase activity|nucleoside-triphosphatase activity|phosphodiesterase I activity	cellular_component
YBR146W	YBR146W	MRPS9	hom	Verified	2.62471704416786	0.00433605008179562	no	120	0.00504414055344845	68	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YLR239C	YLR239C	LIP2	hom	Verified	2.59137106887924	0.0047797177152307	no	121	0.018951459979163	178	NA	FF|FT	KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Lipoyl ligase, involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups	protein lipoylation	ligase activity	mitochondrion
YPL042C	YPL042C	SSN3	hom	Verified	2.58456709911426	0.00487506653716924	no	122	0.0147834511449426	141	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression	phosphorylation of RNA polymerase II C-terminal domain|negative regulation of transcription from RNA polymerase II promoter|negative regulation of filamentous growth|protein phosphorylation|protein destabilization|nuclear-transcribed mRNA catabolic process, non-stop decay|positive regulation of transcription from RNA polymerase II promoter by galactose	RNA polymerase II carboxy-terminal domain kinase activity|protein kinase activity|cyclin-dependent protein kinase activity	mediator complex
YMR034C_p	YMR034C	YMR034C	hom	Uncharacterized	2.5753659102167	0.00500670454881696	no	123	0.00654358569462434	37	NA					Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene	biological_process	sterol transporter activity	integral to membrane
YDR202C	YDR202C	RAV2	hom	Verified	2.5556050045772	0.00530016863475216	no	124	0.0115065642623347	113	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS			Subunit of RAVE (Rav1p, Rav2p, Skp1p), a complex that associates with the V1 domain of the vacuolar membrane (H+)-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme	vacuolar acidification|regulation of protein complex assembly	molecular_function	RAVE complex
YPR050C_d	YPR050C	YPR050C	hom	Dubious	2.53423995969672	0.00563457665096086	no	125	0.0144043874339397	119	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MAK3/YPR051W	Unknown	Unknown	Unknown
YJL126W	YJL126W	NIT2	hom	Verified	2.52672410872188	0.00575659531955286	no	126	0.00553163386917177	85	NA					Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member	biological_process	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	cellular_component
YOR124C	YOR124C	UBP2	hom	Verified	2.52423789998787	0.00579747159909819	no	127	0.00555195621911727	78	NA	FT	PROTEOLYSIS			Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; interacts with Rsp5p and is required for MVB sorting of membrane proteins; can cleave polyubiquitin and has isopeptidase activity	protein deubiquitination|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	ubiquitin-specific protease activity	cytoplasm
YLR358C_p	YLR358C	YLR358C	hom	Uncharacterized	2.52352737802063	0.00580920066067031	no	128	0.00509288043097833	105	NA					Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps ORF RSC2/YLR357W	biological_process	molecular_function	cellular_component
YGR252W	YGR252W	GCN5	hom	Verified	2.50171080614859	0.00617974185332126	no	129	0.035175121183978	218	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME	HISTONE ACETYLTRANSFERASE	Acetyltransferase, modifies N-terminal lysines on histones H2B and H3; acetylates Rsc4p, a subunit of the RSC chromatin-remodeling complex, altering replication stress tolerance; catalytic subunit of the ADA and SAGA histone acetyltransferase complexes; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; greater involvement in repression of RNAPII-dependent transcription than in activation	histone acetylation|regulation of transcription by chromatin organization|chromatin modification|positive regulation of transcription elongation from RNA polymerase II promoter	histone acetyl-lysine binding|transcription coactivator activity|histone acetyltransferase activity|H3 histone acetyltransferase activity	SLIK (SAGA-like) complex|chromosome, centromeric region|Ada2/Gcn5/Ada3 transcription activator complex|SAGA complex
YNL276C_d	YNL276C	YNL276C	hom	Dubious	2.50031790677977	0.00620409517408467	no	130	0.00501530740172394	70	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene MET2/YNL277W	Unknown	Unknown	Unknown
YNL108C_p	YNL108C	YNL108C	hom	Uncharacterized	2.48923468149432	0.00640092151730975	no	131	0.011474127775987	103	NA	FT		NUCLEUS		Putative protein of unknown function; similar to prokaryotic phosphotransfer enzymes; null mutant shows alterations in glucose metabolism; GFP-fusion protein localizes to the cytoplasm and nucleus; YNL108C has a paralog, TFC7, that arose from the whole genome duplication	biological_process	molecular_function	nucleus|cytoplasm
YOL098C_p	YOL098C	YOL098C	hom	Uncharacterized	2.48663793022223	0.00644782846608175	no	132	0.00607853403479934	86	NA	FT	PROTEOLYSIS			Putative metalloprotease	biological_process	molecular_function	cytoplasm
YKL011C	YKL011C	CCE1	hom	Verified	2.47854758442874	0.00659592567886382	no	133	0.00854316158476459	95	NA	FT	MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial cruciform cutting endonuclease, cleaves Holliday junctions formed during recombination of mitochondrial DNA	mitochondrial genome maintenance	endodeoxyribonuclease activity	mitochondrial inner membrane
YKR047W_d	YKR047W	YKR047W	hom	Dubious	2.46955822729646	0.00676400002771239	no	134	0.0105554786062811	126	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NAP1	Unknown	Unknown	Unknown
YER061C	YER061C	CEM1	hom	Verified	2.46896544180036	0.0067752151956761	no	135	0.0114655767244457	133	NA	FT	KETONE METABOLISM|LIPID METABOLISM	MITOCHONDRION		Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration	fatty acid biosynthetic process	fatty acid synthase activity	mitochondrion
YMR153C-A_d	YMR153C-A	YMR153C-A	hom	Dubious	2.45414846621631	0.00706093317226293	no	136	0.00184006201112248	57	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NUP53	Unknown	Unknown	Unknown
YFR030W	YFR030W	MET10	hom	Verified	2.4531418260893	0.00708072457987651	no	137	0.00749478506669186	101	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY			Subunit alpha of assimilatory sulfite reductase, which converts sulfite into sulfide	sulfate assimilation	sulfite reductase (NADPH) activity	sulfite reductase complex (NADPH)
YBR242W_p	YBR242W	YBR242W	hom	Uncharacterized	2.44835401759223	0.0071755285824455	no	138	0.016586799782254	107	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR242W is not an essential gene	biological_process	molecular_function	nucleus|cytoplasm
YDR447C	YDR447C	RPS17B	hom	Verified	2.4431438331052	0.00727996659800364	no	139	0.00888943555020891	71	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17B has a paralog, RPS17A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	cytoplasmic translation|ribosomal small subunit assembly	structural constituent of ribosome	cytosolic small ribosomal subunit
YOR229W	YOR229W	WTM2	hom	Verified	2.44088868458805	0.0073255850336526	no	140	0.00648472159838672	74	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS		Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; involved in response to replication stress; contains WD repeats	negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of transcription from RNA polymerase II promoter during meiosis|cellular protein complex localization|negative regulation of chromatin silencing at telomere|response to DNA damage stimulus|positive regulation of transcription from RNA polymerase II promoter	protein binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|transcription corepressor activity	nucleus
YML097C	YML097C	VPS9	hom	Verified	2.41425135356113	0.00788379041019172	no	141	0.00943991609355688	164	NA	FF|FT	PROTEIN LOCALIZATION|VACUOLAR TRANSPORT			A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin	vacuole inheritance|protein targeting to vacuole	ubiquitin binding|guanyl-nucleotide exchange factor activity	cytosol
YLL043W	YLL043W	FPS1	hom	Verified	2.38889612390632	0.00844953982035724	no	142	0.00884283602859228	131	NA	FT	ION HOMEOSTASIS|CARBOHYDRATE METABOLISM|ION HOMEOSTASIS	PLASMA MEMBRANE		Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress	conjugation with cellular fusion|transport|arsenite transport|glycerol transport|acetate transport|response to arsenic-containing substance	glycerol transmembrane transporter activity|transporter activity	integral to membrane|plasma membrane|fungal-type vacuole|cytoplasm
YPL032C	YPL032C	SVL3	hom	Verified	2.36878726138464	0.00892325771168844	no	143	0.0181983275401771	116	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS	SITE OF POLARIZED GROWTH		Protein of unknown function; mutant phenotype suggests a potential role in vacuolar function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; relocalizes from bud neck to cytoplasm upon DNA replication stress	endocytosis	molecular_function	cellular bud|cellular bud neck|cytoplasm
YJL154C	YJL154C	VPS35	hom	Verified	2.35975349303481	0.00914354107644752	no	144	0.0229131552250605	201	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM		Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p	protein retention in Golgi apparatus|retrograde transport, endosome to Golgi	protein transporter activity	endosome|retromer complex, inner shell|retromer complex
YOR113W	YOR113W	AZF1	hom	Verified	2.35952956653797	0.00914906133810392	no	145	0.0129617030374186	84	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL WALL ORG/BIOGENESIS	NUCLEUS		Zinc-finger transcription factor; in the presence of glucose, activates transcription of genes involved in growth and carbon metabolism; in nonfermentable carbon sources, activates transcription of genes involved in maintenance of cell wall integrity	regulation of fungal-type cell wall organization|regulation of transcription from RNA polymerase II promoter|cellular response to carbohydrate stimulus	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YDR481C	YDR481C	PHO8	hom	Verified	2.35810833809666	0.00918416569679992	no	146	0.00994074962767799	90	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			Repressible vacuolar alkaline phosphatase; regulated by levels of Pi and by Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides; contributes to NAD+ metabolism by producing nicotinamide riboside from NMN	nicotinamide nucleotide metabolic process|protein dephosphorylation	nucleotide phosphatase activity|alkaline phosphatase activity	fungal-type vacuole membrane
YFL027C	YFL027C	GYP8	hom	Verified	2.35120683766657	0.00935631436064014	no	147	0.00755661517479164	56	NA	FT	VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM			GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport	vesicle-mediated transport	Rab GTPase activator activity	intracellular
YLR131C	YLR131C	ACE2	hom	Verified	2.35103693769749	0.00936058765162812	no	148	0.0404934724616378	340	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CELL DIVISION	NUCLEUS		Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication	Unknown|regulation of transcription involved in G1 phase of mitotic cell cycle	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding	cytosol|nucleus
YBR194W	YBR194W	AIM4	hom	Verified	2.34048056753624	0.00962947031094225	no	149	0.0210569267000698	128	NA					Protein proposed to be associated with the nuclear pore complex; null mutant is viable, displays elevated frequency of mitochondrial genome loss and is sensitive to freeze-thaw stress	biological_process	molecular_function	cytoplasm
YPL173W	YPL173W	MRPL40	hom	Verified	2.32563082389267	0.0100191268692851	no	150	0.0134690428965439	143	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YLR356W	YLR356W	ATG33	hom	Verified	2.30844219146017	0.0104872773084336	no	151	0.0084000014572374	71	NA	FT		MITOCHONDRION		Mitochondrial mitophagy-specific protein; required primarily for mitophagy induced at the post-log phase; not required for other types of selective autophagy or macroautophagy; conserved within fungi, but not in higher eukaryotes	mitochondrion degradation	molecular_function	mitochondrion|integral to membrane
YGL135W	YGL135W	RPL1B	hom	Verified	2.30256756076925	0.0106515930419146	no	152	0.00984602497349701	85	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L1B; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1B has a paralog, RPL1A, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YMR241W	YMR241W	YHM2	hom	Verified	2.29997682649447	0.0107247664759355	no	153	0.0117990956652982	92	NA	FT	ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Carrier protein that exports citrate from and imports oxoglutarate into the mitochondrion, causing net export of NADPH reducing equivalents; also associates with mt nucleoids and has a role in replication and segregation of the mt genome	tricarboxylic acid transport|mitochondrial citrate transport|alpha-ketoglutarate transport|mitochondrial genome maintenance	tricarboxylate secondary active transmembrane transporter activity|DNA binding	mitochondrial nucleoid|mitochondrion|integral to membrane|mitochondrial inner membrane
YBR058C	YBR058C	UBP14	hom	Verified	2.28718433995275	0.0110925328413962	no	154	0.0131426037269179	115	NA	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS	NUCLEUS		Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase T	protein deubiquitination|negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process	ubiquitin-specific protease activity	cytoplasm
YLR294C_d	YLR294C	YLR294C	hom	Dubious	2.283276031568	0.0112070569749649	no	155	0.0117058289052696	98	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ATP14	Unknown	Unknown	Unknown
YJL022W_d	YJL022W	YJL022W	hom	Dubious	2.26789887321223	0.0116676855245903	no	156	0.0137991964456613	80	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130	Unknown	Unknown	Unknown
YJR074W	YJR074W	MOG1	hom	Verified	2.2608823826296	0.0118832706684272	no	157	0.0141980981539504	138	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	NUCLEUS		Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p	protein import into nucleus	Ran GTPase binding	nucleus
YCR048W	YCR048W	ARE1	hom	Verified	2.24696964456505	0.0123209835803446	no	158	0.0045398344246878	46	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the absence of oxygen; ARE1 has a paralog, ARE2, that arose from the whole genome duplication	sterol metabolic process	ergosterol O-acyltransferase activity|lanosterol O-acyltransferase activity	integral to membrane|endoplasmic reticulum
YNL121C	YNL121C	TOM70	hom	Verified	2.24624433784841	0.0123441808524911	no	159	0.0346714854599792	192	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Component of the TOM (translocase of outer membrane) complex; involved in the recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins; TOM70 has a paralog, TOM71, that arose from the whole genome duplication	protein import into mitochondrial matrix|protein import into mitochondrial inner membrane	mitochondrion targeting sequence binding|protein channel activity	mitochondrial outer membrane|mitochondrion|integral to membrane|integral to mitochondrial outer membrane|mitochondrial outer membrane translocase complex
YHR030C	YHR030C	SLT2	hom	Verified	2.24555623219624	0.0123662232970282	no	160	0.0619254750263169	460	NA	FF|FT	PROTEIN LOCALIZATION|RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|CELL DIVISION|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION	NUCLEUS|SITE OF POLARIZED GROWTH		Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, progression through the cell cycle, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to the phagophore assembly site (PAS); regulated by the PKC1-mediated signaling pathway	protein phosphorylation|endoplasmic reticulum unfolded protein response|signal transduction|UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response|fungal-type cell wall organization|peroxisome degradation|regulation of transcription factor import into nucleus|barrier septum assembly|response to acid|regulation of cell size	MAP kinase activity|protein serine/threonine kinase activity|protein kinase activity	nucleus|cytoplasm|cellular bud tip
YER178W	YER178W	PDA1	hom	Verified	2.22654165486587	0.0129889610423036	no	161	0.0191942684285061	120	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose	acetyl-CoA biosynthetic process from pyruvate	pyruvate dehydrogenase (acetyl-transferring) activity	mitochondrial nucleoid|mitochondrion|mitochondrial pyruvate dehydrogenase complex
YKR077W	YKR077W	MSA2	hom	Verified	2.22158280996878	0.0131557563256779	no	162	0.0118240559701488	104	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE	NUCLEUS		Putative transcriptional activator, that interacts with G1-specific transcription factor, MBF and G1-specific promoters; ortholog of Msa2p, an MBF and SBF activator that regulates G1-specific transcription and cell cycle initiation	regulation of transcription involved in G1 phase of mitotic cell cycle	molecular_function	nucleus|cytoplasm
YKR061W	YKR061W	KTR2	hom	Verified	2.22046520243457	0.0131936026325642	no	163	0.00836917619375991	79	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Mannosyltransferase involved in N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR2 has a paralog, YUR1, that arose from the whole genome duplication	cell wall mannoprotein biosynthetic process|protein N-linked glycosylation	mannosyltransferase activity	Golgi apparatus
YLR327C	YLR327C	TMA10	hom	Verified	2.21336201328729	0.013436348689118	no	164	0.0130717525217701	81	NA	FT		NUCLEUS|MITOCHONDRION		Protein of unknown function that associates with ribosomes; putative homolog of the F1F0-ATPase synthase regulator Stf2p; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	ribosome|nucleus|cytoplasm
YDR077W	YDR077W	SED1	hom	Verified	2.21297879287991	0.0134495538822848	no	165	0.0103778151573755	109	NA	FT	CELL WALL ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Major stress-induced structural GPI-cell wall glycoprotein in stationary-phase cells, associates with translating ribosomes, possible role in mitochondrial genome maintenance; ORF contains two distinct variable minisatellites	fungal-type cell wall organization|mitochondrial genome maintenance	structural constituent of cell wall	mitochondrion|ribosome|fungal-type cell wall
YJL057C	YJL057C	IKS1	hom	Verified	2.21053750941259	0.0135339401399831	no	166	0.0129237088814238	97	NA	FT	PROTEIN PHOSPHORYLATION			Protein kinase of unknown cellular role; putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts with an N-terminal fragment of Sst2p	protein phosphorylation	protein kinase activity	cellular_component
YER047C	YER047C	SAP1	hom	Verified	2.20897389406137	0.0135882283829429	no	167	0.0169512247892658	117	NA					Putative ATPase of the AAA family, interacts with the Sin1p transcriptional repressor in the two-hybrid system	biological_process	ATPase activity	cytoplasm
YOR285W	YOR285W	RDL1	hom	Verified	2.20096932571498	0.0138690977225729	no	168	0.0111545850412373	106	NA	FT		ENDOPLASMIC RETICULUM|MITOCHONDRION		Protein of unknown function containing a rhodanese-like domain; localized to the mitochondrial outer membrane; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion|endoplasmic reticulum
YOL118C_d	YOL118C	YOL118C	hom	Dubious	2.20071171670569	0.0138782194112154	no	169	0.0173537481800559	106	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YAL058W	YAL058W	CNE1	hom	Verified	2.19903622664869	0.0139376732470493	no	170	0.0117030667856783	129	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast	protein folding|ER-associated protein catabolic process	unfolded protein binding	integral to endoplasmic reticulum membrane
YAR018C	YAR018C	KIN3	hom	Verified	2.19864986666489	0.0139514141314846	no	171	0.0196556226187103	103	NA	FT	PROTEIN PHOSPHORYLATION|CHROMOSOME SEGREGATION			Nonessential serine/threonine protein kinase; possible role in DNA damage response	chromosome segregation|protein phosphorylation	protein kinase activity	cellular_component
YNL070W	YNL070W	TOM7	hom	Verified	2.19143052808274	0.0142103259780371	no	172	0.0195875874191183	190	NA	FF|FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex	protein import into mitochondrial matrix|protein import into mitochondrial outer membrane	protein channel activity	mitochondrial outer membrane|mitochondrion|integral to membrane|mitochondrial outer membrane translocase complex
YKL053C-A	YKL053C-A	MDM35	hom	Verified	2.19118370849323	0.0142192505261612	no	173	0.0177049438049196	120	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	NUCLEUS|MITOCHONDRION		Mitochondrial intermembrane space protein; mutation affects mitochondrial distribution and morphology; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress	mitochondrion organization|mitochondrial respiratory chain complex assembly	molecular_function	nucleus|cytoplasm|mitochondrial intermembrane space
YDR336W_p	YDR336W	YDR336W	hom	Uncharacterized	2.18440178106015	0.0144663687346173	no	174	0.0179066372079865	121	NA					Putative protein of unknown function; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene	biological_process	molecular_function	cellular_component
YGR236C	YGR236C	SPG1	hom	Verified	2.1833880700402	0.0145036218754383	no	175	0.0131598768454314	89	NA	FT		MITOCHONDRION		Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YNL154C	YNL154C	YCK2	hom	Verified	2.17888406139143	0.0146701410498105	no	176	0.0168412835371789	107	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL DIVISION|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; YCK2 has a paralog, YCK1, that arose from the whole genome duplication	endocytosis|cell morphogenesis|protein phosphorylation|cytokinesis|response to glucose stimulus	protein serine/threonine kinase activity|protein kinase activity	plasma membrane|cellular bud neck|mating projection
YFR018C_p	YFR018C	YFR018C	hom	Uncharacterized	2.1763185718445	0.0147657238932298	no	177	0.0120192109824706	88	NA	FT	PROTEOLYSIS			Putative protein of unknown function	biological_process	molecular_function	cellular_component
YLR265C	YLR265C	NEJ1	hom	Verified	2.17626658785766	0.0147676661925668	no	178	0.0115465002417889	88	NA	FT	RESPONSE TO DNA DAMAGE	ENDOMEMBRANE SYSTEM|NUCLEUS		Protein involved in regulation of nonhomologous end joining; interacts with DNA ligase IV components Dnl4p and Lif1p; repressed by MAT heterozygosity; regulates cellular distribution of Lif1p	double-strand break repair via nonhomologous end joining|double-strand break repair via single-strand annealing	DNA end binding	DNA ligase IV complex|nucleus
YOR068C	YOR068C	VAM10	hom	Verified	2.16722294062656	0.0151089294850407	no	179	0.0182154777398849	162	NA	FT	MEMBRANE ORGANIZATION			Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering	vacuole fusion, non-autophagic	molecular_function	fungal-type vacuole membrane
YPL223C	YPL223C	GRE1	hom	Verified	2.16207469533307	0.015306209575983	no	180	0.0196858742032965	87	NA					Hydrophilin essential in dessication-rehydration process; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway	biological_process	molecular_function	cytoplasm
YJL139C	YJL139C	YUR1	hom	Verified	2.16027252796178	0.0153757891876354	no	181	0.0169588093188547	126	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Mannosyltransferase involved in protein N-glycosylation; member of the KTR1 family; located in the Golgi apparatus; YUR1 has a paralog, KTR2, that arose from the whole genome duplication	cell wall mannoprotein biosynthetic process|protein N-linked glycosylation	mannosyltransferase activity	Golgi apparatus
YKL113C	YKL113C	RAD27	hom	Verified	2.15180617016581	0.0157063118440917	no	182	0.0311644240836415	201	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION		5' to 3' exonuclease, 5' flap endonuclease, required for Okazaki fragment processing and maturation as well as for long-patch base-excision repair; member of the S. pombe RAD2/FEN1 family	double-strand break repair via nonhomologous end joining|replicative cell aging|DNA replication, removal of RNA primer|base-excision repair, base-free sugar-phosphate removal|gene conversion at mating-type locus, DNA repair synthesis	5'-3' exonuclease activity|5'-flap endonuclease activity	mitochondrion|nucleus
YBR023C	YBR023C	CHS3	hom	Verified	2.14891002096653	0.0158207666497918	no	183	0.0211198262100841	199	NA	FT	CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM	SITE OF POLARIZED GROWTH		Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan	ascospore wall assembly|fungal-type cell wall chitin biosynthetic process|cytokinesis	chitin synthase activity	incipient cellular bud site|integral to membrane|chitosome|prospore membrane|cellular bud neck|mating projection tip|cytoplasm
YDR001C	YDR001C	NTH1	hom	Verified	2.1449123220083	0.0159799289273274	no	184	0.0125454044481688	97	NA	FT	CARBOHYDRATE METABOLISM			Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p; NTH1 has a paralog, NTH2, that arose from the whole genome duplication	trehalose catabolic process|response to stress	alpha,alpha-trehalase activity	cytosol|cytoplasm
YGR242W_d	YGR242W	YGR242W	hom	Dubious	2.14242229949195	0.0160797575216118	no	185	0.0166025661442416	128	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C	Unknown	Unknown	Unknown
YHR206W	YHR206W	SKN7	hom	Verified	2.13953581591081	0.0161961492341349	no	186	0.0313896765635797	223	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|SIGNALING|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Nuclear response regulator and transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; part of a branched two-component signaling system; required for optimal induction of heat-shock genes in response to oxidative stress; involved in osmoregulation; SKN7 has a paralog, HMS2, that arose from the whole genome duplication	response to singlet oxygen|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|transcription, DNA-dependent|response to osmotic stress|regulation of cell size	sequence-specific DNA binding|two-component response regulator activity|sequence-specific DNA binding transcription factor activity	nucleus
YEL006W	YEL006W	YEA6	hom	Verified	2.12883691385484	0.0166338778432133	no	187	0.0177043232632445	130	NA	FT		MITOCHONDRION		Putative mitochondrial NAD+ transporter, member of the mitochondrial carrier subfamily (see also YIA6); has putative human ortholog	transport|NAD transmembrane transport	transporter activity|NAD transporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YOL070C	YOL070C	NBA1	hom	Verified	2.12639994539174	0.0167349861575242	no	188	0.0185528094350965	131	NA	FT		SITE OF POLARIZED GROWTH		Protein of unknown function, localizes to the bud neck and cytoplasm; interacts with Nap1p; may interact with ribosomes, based on co-purification experiments; potential Cdc28p substrate	biological_process	molecular_function	ribosome|cellular bud neck|cytoplasm
YKL205W	YKL205W	LOS1	hom	Verified	2.12604020487545	0.016749956013317	no	189	0.0175155203636698	78	NA	FT	RNA PROCESSING|RNA LOCALIZATION	NUCLEUS|MITOCHONDRION		Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm	tRNA re-export from nucleus|tRNA splicing, via endonucleolytic cleavage and ligation|tRNA export from nucleus	tRNA binding|Ran GTPase binding	mitochondrion|integral to membrane|nuclear matrix|cytoplasm
YMR002W	YMR002W	MIC17	hom	Verified	2.12571313067217	0.0167635764688451	no	190	0.0199966951258206	123	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS|MITOCHONDRION		Mitochondrial intermembrane space protein; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress	aerobic respiration	molecular_function	nucleus|cytoplasm|mitochondrial intermembrane space
YPR120C	YPR120C	CLB5	hom	Verified	2.11955778739241	0.0170216777742744	no	191	0.0241884800962079	184	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	NUCLEUS		B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase	spindle assembly|G1/S transition of mitotic cell cycle|regulation of S phase of mitotic cell cycle|G2/M transition of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|positive regulation of spindle pole body separation|premeiotic DNA replication|positive regulation of DNA replication	cyclin-dependent protein kinase regulator activity	nucleus
YNL116W	YNL116W	DMA2	hom	Verified	2.1171451656537	0.0171237647463254	no	192	0.0284745683078905	154	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION			Ubiquitin-protein ligase (E3); controls septin dynamics and the spindle position checkpoint (SPOC) along with functionally redundant ligase Dma1p by regulating the recruitment of Elm1p to the bud neck; regulates levels of the translation initiation factor eIF2 subunit Gcd11p, as well as abundance, localization, and ubiquitination of Cdk inhibitory kinase Swe1p; ortholog of human RNF8 protein, with sequence similarity to human Chfr; contains FHA and RING finger domains	establishment of mitotic spindle orientation|protein autoubiquitination|septin ring assembly|mitotic cell cycle spindle assembly checkpoint	ubiquitin-protein ligase activity	cytoplasm
YLL030C_d	YLL030C	RRT7	hom	Dubious	2.1161773328344	0.0171648641472611	no	193	0.0121146429300524	92	NA					Identified in a screen for mutants with increased levels of rDNA transcription; dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YEL018W	YEL018W	EAF5	hom	Verified	2.10560457715166	0.0176193573707266	no	194	0.0232227202513339	129	NA	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS	HISTONE ACETYLTRANSFERASE	Esa1p-associated factor, non-essential subunit of the NuA4 acetyltransferase complex	DNA repair	molecular_function	nucleus|NuA4 histone acetyltransferase complex
YML081W	YML081W	TDA9	hom	Verified	2.09578814569881	0.0180504941995201	no	195	0.0164721509948937	119	NA	FT		NUCLEUS		DNA-binding protein, putative transcription factor; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; TDA9 has a paralog, RSF2, that arose from the whole genome duplication	biological_process	sequence-specific DNA binding	nucleus
YDL006W	YDL006W	PTC1	hom	Verified	2.09393893195578	0.0181327102998303	no	196	0.0625385698531792	306	NA	FF|FT	RNA PROCESSING|SIGNALING|MITOCHONDRION ORGANIZATION|PROTEIN PHOSPHORYLATION	NUCLEUS		Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p, inactivating osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing, mitochondrial inheritance, and sporulation	mitochondrion inheritance|inactivation of MAPK activity involved in osmosensory signaling pathway|pheromone-dependent signal transduction involved in conjugation with cellular fusion|tRNA splicing, via endonucleolytic cleavage and ligation|protein dephosphorylation	protein serine/threonine phosphatase activity	nucleus|cytoplasm
YBR037C	YBR037C	SCO1	hom	Verified	2.08946403579646	0.0183329860484265	no	197	0.0231899167162696	159	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Copper-binding protein of mitochondrial inner membrane; required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; similar to thioredoxins; SCO1 has a paralog, SCO2, that arose from the whole genome duplication	copper ion transport|response to redox state|protein complex assembly	copper ion binding|thioredoxin peroxidase activity	mitochondrion|mitochondrial inner membrane
YOR155C	YOR155C	ISN1	hom	Verified	2.0893366652672	0.0183387140399427	no	198	0.0163318120388624	56	NA	FT	NUCLEOTIDE METABOLISM			Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms	nicotinamide riboside biosynthetic process|inosine salvage|nicotinic acid riboside biosynthetic process	IMP 5'-nucleotidase activity	cellular_component
YMR040W	YMR040W	YET2	hom	Verified	2.0853062450084	0.0185207554597326	no	199	0.0215603678180333	59	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein	biological_process	molecular_function	ribosome|integral to membrane
YBL048W_d	YBL048W	RRT1	hom	Dubious	2.07566980430936	0.0189622502553605	no	200	0.0284414224050734	181	NA					Identified in a screen for mutants with increased levels of rDNA transcription; dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data	Unknown	Unknown	Unknown
YPL056C_p	YPL056C	LCL1	hom	Uncharacterized	2.074559542474	0.0190136874908955	no	201	0.0260398717682569	153	NA	FT		PLASMA MEMBRANE		Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan	biological_process	molecular_function	cellular_component
YLR253W_p	YLR253W	YLR253W	hom	Uncharacterized	2.07452209701209	0.0190154243653126	no	202	0.0185937235505525	121	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; transcription is periodic during the metabolic cycle; YLR253W is not an essential gene	biological_process	molecular_function	mitochondrion
YKL161C	YKL161C	KDX1	hom	Verified	2.0699223259779	0.0192298094223169	no	203	0.0291486678133626	161	NA	FT	PROTEIN PHOSPHORYLATION			Protein kinase implicated in the Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p	biological_process	protein kinase activity	cellular_component
YIL166C_p	YIL166C	YIL166C	hom	Uncharacterized	2.06311473723856	0.0195508641568796	no	204	0.0205172416682928	115	NA					Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; YIL166C is a non-essential gene	transport	transporter activity	integral to membrane|membrane
YGL253W	YGL253W	HXK2	hom	Verified	2.06267677269945	0.0195716740809365	no	205	0.0208980844198224	152	NA	FT	CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS|MITOCHONDRION		Hexokinase isoenzyme 2; catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene; phosphorylation/dephosphorylation at serine-14 by protein kinase Snf1p and protein phosphatase Glc7p-Reg1p regulates nucleocytoplasmic shuttling of Hxk2p; HXK2 has a paralog, HXK1, that arose from the whole genome duplication	replicative cell aging|fructose import|regulation of transcription by glucose|glucose import|mannose metabolic process|glycolysis|glucose metabolic process|regulation of cell size|fructose metabolic process	hexokinase activity	cytosol|mitochondrion|nucleus
YOR246C	YOR246C	ENV9	hom	Verified	2.06074223229369	0.0196638191339118	no	206	0.024828609625802	251	NA	FF|FT	OXIDATION-REDUCTION PROCESS|VACUOLAR PROTEIN PROCESSING			Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts	vacuole organization|vacuolar protein processing	oxidoreductase activity	lipid particle
YGR164W_d	YGR164W	YGR164W	hom	Dubious	2.05619343828764	0.0198819372573214	no	207	0.019354055817866	191	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YBR058C-A	YBR058C-A	TSC3	hom	Verified	2.05385252359085	0.019994983787411	no	208	0.138865149025807	694	NA	FF|FT	KETONE METABOLISM|LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis	3-keto-sphinganine metabolic process|sphingolipid biosynthetic process	enzyme activator activity	SPOTS complex
YNL230C	YNL230C	ELA1	hom	Verified	2.04760916630134	0.020299155235866	no	209	0.0240837383740434	152	NA	FT	PROTEOLYSIS	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Elongin A; F-box protein that forms a heterodimer with Elc1p and is required for ubiquitin-dependent degradation of the RNA Polymerase II subunit Rpo21p; subunit of the Elongin-Cullin-Socs (ECS) ligase complex	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity	elongin complex|Cul3-RING ubiquitin ligase complex
YOR127W	YOR127W	RGA1	hom	Verified	2.04590600395234	0.0203828097636273	no	210	0.0200495586443046	133	NA	FT	SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		GTPase-activating protein for polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; relocalizes from bud neck to cytoplasm upon DNA replication stress	budding cell isotropic bud growth|pheromone-dependent signal transduction involved in conjugation with cellular fusion|pseudohyphal growth|actin filament organization|establishment of cell polarity|small GTPase mediated signal transduction|invasive growth in response to glucose limitation|budding cell apical bud growth	Rho GTPase activator activity	cellular bud neck split septin rings
YDL070W	YDL070W	BDF2	hom	Verified	2.04527414846982	0.0204139189401569	no	211	0.0168484396274179	143	NA	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS		Protein involved in transcription initiation; acts at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf1p; protein abundance increases in response to DNA replication stress	negative regulation of heterochromatin assembly	histone acetyl-lysine binding|core promoter binding|histone binding|TFIID-class transcription factor binding	nucleus
YPR124W	YPR124W	CTR1	hom	Verified	2.04495059386031	0.0204298646063997	no	212	0.0856534109087505	417	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		High-affinity copper transporter of the plasma membrane; mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels; protein increases in abundance and relocalizes from nucleus to plasma membrane upon DNA replication stress	copper ion import	copper uptake transmembrane transporter activity	integral to membrane|plasma membrane
YGR178C	YGR178C	PBP1	hom	Verified	2.04353444080808	0.0204997808044209	no	213	0.0268766101871526	211	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION	NUCLEUS|MITOCHONDRION		Component of glucose deprivation induced stress granules; involved in P-body-dependent granule assembly; similar to human ataxin-2; interacts with Pab1p to regulate mRNA polyadenylation; interacts with Mkt1p to regulate HO translation; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress	positive regulation of translation|mRNA polyadenylation|stress granule assembly	molecular_function	mitochondrion|nucleus|polysome|cytoplasmic stress granule|cytoplasm
YNL042W	YNL042W	BOP3	hom	Verified	2.03877027861901	0.0207364799621347	no	214	0.0126630578892769	69	NA	FT		NUCLEUS		Protein of unknown function, potential Cdc28p substrate; overproduction confers resistance to methylmercury	cellular response to methylmercury	molecular_function	nucleus|cytoplasm
YNR049C	YNR049C	MSO1	hom	Verified	2.03849549784369	0.0207502022731482	no	215	0.0201554309444701	148	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Probable component of the secretory vesicle docking complex; acts at a late step in secretion; shows genetic and physical interactions with Sec1p; required for prospore membrane formation during sporulation; relocalizes from bud neck to nucleus upon DNA replication stress	cellular membrane fusion|ascospore-type prospore membrane assembly|vesicle docking involved in exocytosis	molecular_function	SNARE complex|cellular bud membrane|plasma membrane|prospore membrane|cellular bud neck|cellular bud tip
YPL152W	YPL152W	RRD2	hom	Verified	2.03355220604331	0.0209983824125685	no	216	0.0193284032388295	182	NA	FT	CELL CYCLE|CYTOSKELETON ORGANIZATION			Peptidyl-prolyl cis/trans-isomerase; also activates the phosphotyrosyl phosphatase activity of protein phosphatase 2A (PP2A); regulates G1 phase progression, the osmoresponse, microtubule dynamics; subunit of the Tap42p-Pph21p-Rrd2p complex; protein abundance increases in response to DNA replication stress	mitotic spindle organization in nucleus|response to osmotic stress	peptidyl-prolyl cis-trans isomerase activity|protein phosphatase type 2A regulator activity	protein phosphatase type 2A complex
YLR217W_d	YLR217W	YLR217W	hom	Dubious	2.02849829344858	0.0212547086514042	no	217	0.0238348683830168	103	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CPR6	Unknown	Unknown	Unknown
YLR315W	YLR315W	NKP2	hom	Verified	2.02620769498459	0.0213717527137968	no	218	0.0364575225086923	165	NA	FT	CELL CYCLE|CELL DIVISION	NUCLEUS|CHROMOSOME|CYTOSKELETON	KINETOCHORE	Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2	biological_process	molecular_function	spindle pole body|kinetochore
YOL052C	YOL052C	SPE2	hom	Verified	2.0249605844585	0.0214357058577619	no	219	0.0273811295775508	97	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM	NUCLEUS		S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically	spermidine biosynthetic process|spermine biosynthetic process|pantothenate biosynthetic process	adenosylmethionine decarboxylase activity	nucleus|cytoplasm
YCR034W	YCR034W	FEN1	hom	Verified	2.02347321487055	0.0215121912051807	no	220	0.0470917371042709	292	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|KETONE METABOLISM|LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway; FEN1 has a paralog, ELO1, that arose from the whole genome duplication	fatty acid elongation|vesicle-mediated transport|sphingolipid biosynthetic process	fatty acid elongase activity	integral to membrane|endoplasmic reticulum|endoplasmic reticulum membrane
YEL040W	YEL040W	UTR2	hom	Verified	2.01572674361801	0.0219142787439484	no	221	0.019398327724929	85	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	SITE OF POLARIZED GROWTH|CYTOSKELETON		Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck	cell wall chitin metabolic process|fungal-type cell wall organization	transferase activity, transferring glycosyl groups	cellular bud neck septin ring|fungal-type cell wall
YPR026W	YPR026W	ATH1	hom	Verified	2.01101698041728	0.0221618315882716	no	222	0.0150076398866807	69	NA	FT	CARBOHYDRATE METABOLISM			Acid trehalase required for utilization of extracellular trehalose	trehalose catabolic process|response to stress	alpha,alpha-trehalase activity	fungal-type cell wall|cell wall-bounded periplasmic space|fungal-type vacuole
YGR229C	YGR229C	SMI1	hom	Verified	1.99889501277109	0.0228098572358775	no	223	0.0365627013603439	248	NA	FF|FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS	NUCLEUS|SITE OF POLARIZED GROWTH		Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity	regulation of mitotic cell cycle|regulation of fungal-type cell wall biogenesis	molecular_function	incipient cellular bud site|cellular bud neck|mating projection tip
YFL034C-A	YFL034C-A	RPL22B	hom	Verified	1.99050298746374	0.0232677776144339	no	224	0.026375688399668	168	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L22B; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22B has a paralog, RPL22A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YPL220W	YPL220W	RPL1A	hom	Verified	1.98875887201396	0.0233639121885981	no	225	0.0157983488252287	109	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L1A; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1A has a paralog, RPL1B, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YDR372C	YDR372C	VPS74	hom	Verified	1.98820057388916	0.0233947557738243	no	226	0.0384138420382452	217	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING	ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS		Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33	retrograde vesicle-mediated transport, Golgi to ER|endoplasmic reticulum unfolded protein response|protein localization to Golgi apparatus	enzyme binding|phosphatidylinositol-4-phosphate binding	cytosol|Golgi apparatus|nucleus|extrinsic to membrane|cytoplasm
YIR034C	YIR034C	LYS1	hom	Verified	1.98809233116019	0.0234007396856506	no	227	0.0302992928139642	154	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS			Saccharopine dehydrogenase (NAD+, L-lysine-forming), catalyzes the conversion of saccharopine to L-lysine, which is the final step in the lysine biosynthesis pathway; also has mRNA binding activity	lysine biosynthetic process|lysine biosynthetic process via aminoadipic acid	saccharopine dehydrogenase (NAD+, L-lysine-forming) activity|mRNA binding	cytoplasm
YDL116W	YDL116W	NUP84	hom	Verified	1.97472276361942	0.0241498090945505	no	228	0.0235424326986675	180	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RIBOSOME BIOGENESIS|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP107	double-strand break repair|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|maintenance of chromatin silencing at telomere|nuclear pore distribution|telomere tethering at nuclear periphery|response to DNA damage stimulus|mRNA export from nucleus in response to heat stress|mRNA export from nucleus|positive regulation of transcription, DNA-dependent|protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette	structural constituent of nuclear pore	integral to membrane|nuclear pore outer ring|nuclear pore
YOL084W	YOL084W	PHM7	hom	Verified	1.97278755356782	0.024259885900604	no	229	0.00853056595325888	63	NA	FT		PLASMA MEMBRANE		Protein of unknown function; expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YFR019W	YFR019W	FAB1	hom	Verified	1.97139729347059	0.024339225198437	no	230	0.030157472581713	208	NA	FT	LIPID METABOLISM	MITOCHONDRION		1-phosphatidylinositol-3-phosphate 5-kinase; vacuolar membrane kinase that generates phosphatidylinositol (3,5)P2, which is involved in vacuolar sorting and homeostasis	phosphatidylinositol phosphorylation	1-phosphatidylinositol-3-phosphate 5-kinase activity|phosphatidylinositol-3-phosphate binding	endosome membrane|mitochondrion|fungal-type vacuole membrane|PAS complex
YBL086C_p	YBL086C	YBL086C	hom	Uncharacterized	1.96642407840913	0.0246248221596033	no	231	0.0163590623543969	77	NA					Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery	biological_process	molecular_function	cellular_component
YOR355W	YOR355W	GDS1	hom	Verified	1.96206936547238	0.0248772044855524	no	232	0.0319690836820663	225	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS|MITOCHONDRION		Protein of unknown function, required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	aerobic respiration	molecular_function	mitochondrion|nucleus|cytoplasm
YHR063C	YHR063C	PAN5	hom	Verified	1.9569318278465	0.0251777419674935	no	233	0.0307655735668074	156	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM			2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panE	pantothenate biosynthetic process	2-dehydropantoate 2-reductase activity	cytoplasm
YNL066W	YNL066W	SUN4	hom	Verified	1.95276903353062	0.0254234847130781	no	234	0.0258031633368229	142	NA	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family	mitochondrion organization	glucosidase activity	fungal-type cell wall|mitochondrial matrix
YLR171W_d	YLR171W	YLR171W	hom	Dubious	1.93601761630739	0.0264327717139751	no	235	0.0304576587737899	235	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR181C	YDR181C	SAS4	hom	Verified	1.93138589862613	0.0267176738501937	no	236	0.0442007717109821	216	NA	FT	CHROMATIN ORGANIZATION|PROTEOLYSIS|GENE SILENCING	NUCLEUS|CHROMOSOME	HISTONE ACETYLTRANSFERASE	Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p	chromatin silencing at telomere	acetyltransferase activity|histone acetyltransferase activity	nuclear chromatin|SAS acetyltransferase complex|nuclear chromosome, telomeric region
YGR110W	YGR110W	CLD1	hom	Verified	1.92582565226922	0.0270630736363304	no	237	0.0331055082244907	101	NA	FT	LIPID METABOLISM	MITOCHONDRION		Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58	cardiolipin acyl-chain remodeling|cardiolipin metabolic process	phospholipase A2 activity	mitochondrion
YGL084C	YGL084C	GUP1	hom	Verified	1.92505497896145	0.0271112402388794	no	238	0.0947389433982344	439	NA	FF|FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; proposed to be involved in glycerol transport	GPI anchor biosynthetic process|glycerol transport|glycerol catabolic process	O-acyltransferase activity	integral to membrane|endoplasmic reticulum|plasma membrane|membrane
YBR172C	YBR172C	SMY2	hom	Verified	1.92343939309841	0.0272124455338803	no	239	0.0172727154620151	119	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein of unknown function involved in COPII vesicle formation; interacts with the Sec23p/Sec24p subcomplex; overexpression suppresses the temperature sensitivity of a myo2 mutant; similar to S. pombe Mpd2; SMY2 has a paralog, SYH1, that arose from the whole genome duplication	ER to Golgi vesicle-mediated transport	molecular_function	endoplasmic reticulum membrane|cytoplasmic mRNA processing body|cytoplasm|extrinsic to membrane
YPL200W	YPL200W	CSM4	hom	Verified	1.92336835185892	0.0272169030014053	no	240	0.0256555079239268	162	NA	FT	CELL CYCLE|CHROMOSOME SEGREGATION	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|CHROMOSOME		Protein required for accurate chromosome segregation during meiosis; involved in meiotic telomere clustering (bouquet formation) and telomere-led rapid prophase movements	meiotic telomere clustering|meiotic chromosome segregation|synapsis|regulation of reciprocal meiotic recombination	molecular_function	nuclear chromosome, telomeric region|endoplasmic reticulum membrane
YLR098C	YLR098C	CHA4	hom	Verified	1.92315406714387	0.0272303519402537	no	241	0.028584920133273	133	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		DNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain	positive regulation of transcription, DNA-dependent|cellular amino acid catabolic process	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YGL177W_d	YGL177W	YGL177W	hom	Dubious	1.9202376227472	0.0274139456912891	no	242	0.041128778894838	187	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YIR032C	YIR032C	DAL3	hom	Verified	1.91711733985675	0.0276115131052515	no	243	0.0283689380639268	191	NA	FT		PLASMA MEMBRANE		Ureidoglycolate hydrolase, converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation; expression sensitive to nitrogen catabolite repression	allantoin catabolic process	ureidoglycolate hydrolase activity	membrane
YPL114W_d	YPL114W	YPL114W	hom	Dubious	1.91411230962088	0.0278029035015424	no	244	0.0255579516203753	154	NA					Dubious open reading frame, unlikely to encode a functional protein; largely overlaps ORF YPL113C; diploid deletion in BY4743 strain background exhibits high budding index	Unknown	Unknown	Unknown
YCL044C	YCL044C	MGR1	hom	Verified	1.91072306061939	0.0280200898383053	no	245	0.0227692181177207	106	NA	FT	PROTEOLYSIS	MITOCHONDRION		Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr3p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA	misfolded or incompletely synthesized protein catabolic process	misfolded protein binding	mitochondrion|i-AAA complex
YGR166W	YGR166W	TRS65	hom	Verified	1.9088877338548	0.0281382878553639	no	246	0.0452521542600107	242	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|CELL WALL ORG/BIOGENESIS	GOLGI APPARATUS		Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p; involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi; role in cell wall beta-glucan biosynthesis and the stress response	intra-Golgi vesicle-mediated transport|protein complex assembly	Rab guanyl-nucleotide exchange factor activity	TRAPP complex|trans-Golgi network
YLR058C	YLR058C	SHM2	hom	Verified	1.89776475861395	0.0288635387643429	no	247	0.0259952527480104	142	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	SITE OF POLARIZED GROWTH		Cytosolic serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis	one-carbon metabolic process	glycine hydroxymethyltransferase activity	plasma membrane|mating projection tip|cytoplasm
YPL015C	YPL015C	HST2	hom	Verified	1.895150169886	0.0290362548010258	no	248	0.0415724674183656	183	NA	FT	GENE SILENCING	NUCLEUS		Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro; contains a nuclear export signal (NES); function regulated by its nuclear export	negative regulation of chromatin silencing at telomere|chronological cell aging|chromatin silencing at rDNA|negative regulation of mitotic recombination	NAD-dependent histone deacetylase activity	cytoplasm
YBR076W	YBR076W	ECM8	hom	Verified	1.89467701100053	0.0290676025974627	no	249	0.0315239661820507	128	NA	FT	CELL WALL ORG/BIOGENESIS			Non-essential protein of unknown function	fungal-type cell wall organization	molecular_function	cellular_component
YHL005C_d	YHL005C	YHL005C	hom	Dubious	1.88803812015251	0.0295104165308432	no	250	0.0203696041682755	149	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YHL004W	Unknown	Unknown	Unknown
YPR058W	YPR058W	YMC1	hom	Verified	1.87221035897277	0.0305887532538148	no	251	0.0231112077014027	115	NA	FT		MITOCHONDRION		Putative mitochondrial inner membrane transporter; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; YMC1 has a paralog, YMC2, that arose from the whole genome duplication	mitochondrial transport	organic acid transmembrane transporter activity	mitochondrion|integral to membrane
YIL138C	YIL138C	TPM2	hom	Verified	1.8702074789606	0.030727505772549	no	252	0.0398624019157038	217	NA	FT	VESICLE-MEDIATED TRANSPORT|CELL DIVISION|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|RNA LOCALIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Minor isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p; TPM2 has a paralog, TPM1, that arose from the whole genome duplication	vacuole inheritance|exocytosis|intracellular mRNA localization|budding cell apical bud growth|budding cell isotropic bud growth|mitochondrion inheritance|actin polymerization or depolymerization|vesicle-mediated transport|actin filament organization|establishment of cell polarity|actin filament bundle assembly	actin lateral binding	cellular bud neck contractile ring|actin filament bundle
YAL055W	YAL055W	PEX22	hom	Verified	1.86841265063748	0.0308522875457311	no	253	0.0394933332915097	169	NA	FT	PROTEIN LOCALIZATION|SIGNALING|PEROXISOME ORGANIZATION			Putative peroxisomal membrane protein required for import of peroxisomal proteins, functionally complements a Pichia pastoris pex22 mutation	protein import into peroxisome matrix, receptor recycling|protein targeting to peroxisome	protein anchor	integral to peroxisomal membrane
YKL091C	YKL091C	YKL091C	hom	Verified	1.86534804912648	0.0310663171078316	no	254	0.0328835851548854	159	NA	FT		NUCLEUS		Putative homolog of Sec14p, which is a phosphatidylinositol/phosphatidylcholine transfer protein involved in lipid metabolism; localizes to the nucleus; contains a CRAL/TRIO domain and binds several lipids in a large-scale study	biological_process	phosphatidylcholine binding|phosphatidylinositol transporter activity|phosphatidylinositol binding|phosphatidylcholine transporter activity	nucleus
YBL089W	YBL089W	AVT5	hom	Verified	1.85950325945867	0.0314779188390524	no	255	0.0444537170281355	184	NA					Putative transporter; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; AVT5 has a paralog, AVT6, that arose from the whole genome duplication	transport	transporter activity	integral to membrane
YHL002W	YHL002W	HSE1	hom	Verified	1.85598385162213	0.0317279299095709	no	256	0.0388858987675666	151	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT			Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes	late endosome to vacuole transport|protein targeting to vacuole	ubiquitin binding	endosome|ESCRT-0 complex
YOR357C	YOR357C	SNX3	hom	Verified	1.85564701249935	0.0317519440167139	no	257	0.0331387424830551	205	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p	protein localization|late endosome to Golgi transport	phosphatidylinositol-3-phosphate binding	cytosol|endosome
YGL234W	YGL234W	ADE5,7	hom	Verified	1.85457775581134	0.0318282735251749	no	258	0.0284114716630971	199	NA	FT	NUCLEOTIDE METABOLISM			Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities	purine nucleobase metabolic process|purine nucleotide biosynthetic process|'de novo' IMP biosynthetic process	phosphoribosylamine-glycine ligase activity|phosphoribosylformylglycinamidine cyclo-ligase activity	cytoplasm
YJL108C	YJL108C	PRM10	hom	Verified	1.85059891753821	0.0321136377833273	no	259	0.0395011404281946	178	NA					Pheromone-regulated protein, proposed to be involved in mating; predicted to have 5 transmembrane segments; induced by treatment with 8-methoxypsoralen and UVA irradiation	biological_process	molecular_function	integral to membrane
YBL063W	YBL063W	KIP1	hom	Verified	1.83239240952854	0.0334464890598623	no	260	0.0208223104554277	91	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	CYTOSKELETON		Kinesin-related motor protein required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; functionally redundant with Cin8p for chromosomal but not plasmid functions	mitotic anaphase B|microtubule depolymerization|spindle pole body separation|plasmid partitioning|mitotic sister chromatid segregation	microtubule motor activity|structural constituent of cytoskeleton	spindle microtubule|kinesin complex|spindle pole body
YKR039W	YKR039W	GAP1	hom	Verified	1.83207659701622	0.0334700047663988	no	261	0.0340767100742869	145	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	PLASMA MEMBRANE		General amino acid permease; Gap1p senses the presence of amino acid substrates to regulate localization to the plasma membrane when needed; essential for invasive growth	amino acid transport|gamma-aminobutyric acid transport|ammonia assimilation cycle|polyamine transport	amino acid transmembrane transporter activity|polyamine transmembrane transporter activity|L-proline transmembrane transporter activity	endosome|fungal-type vacuole lumen|integral to membrane|plasma membrane|ER to Golgi transport vesicle|integral to plasma membrane|multivesicular body
YDR279W	YDR279W	RNH202	hom	Verified	1.82333299168086	0.0341264861970783	no	262	0.0242882943516107	130	NA	FT		NUCLEUS		Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS2 that causes Aicardi-Goutieres syndrome	RNA catabolic process|DNA replication, removal of RNA primer	ribonuclease H activity	ribonuclease H2 complex|nucleus
YMR326C_d	YMR326C	YMR326C	hom	Dubious	1.81637726171031	0.0346562603776365	no	263	0.0329746519445564	163	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the telomere on the right arm of chromosome 13	Unknown	Unknown	Unknown
YLR385C	YLR385C	SWC7	hom	Verified	1.81210919121039	0.0349846632401968	no	264	0.0323646286112553	137	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin	chromatin remodeling	molecular_function	Swr1 complex|nucleus
YPR195C_d	YPR195C	YPR195C	hom	Dubious	1.81102058587605	0.0350688325659736	no	265	0.0337586707007773	167	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YIL052C	YIL052C	RPL34B	hom	Verified	1.80744970775359	0.0353460947534172	no	266	0.0631711055173931	347	NA	FF|FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YBR279W	YBR279W	PAF1	hom	Verified	1.80383896644872	0.0356282776235681	no	267	0.0691468784888798	341	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|GENE SILENCING	NUCLEUS|CHROMOSOME	RNA POL II, HOLOENZYME	Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cell cycle-regulated genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; homolog of human PD2/hPAF1	negative regulation of DNA recombination|mRNA 3'-end processing|snoRNA transcription from an RNA polymerase II promoter|regulation of transcription by chromatin organization|transcription from RNA polymerase I promoter|regulation of transcription-coupled nucleotide-excision repair|rRNA processing|transcription elongation from RNA polymerase I promoter|regulation of chromatin silencing at telomere|regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of histone H3-K4 methylation|negative regulation of transcription from RNA polymerase II promoter|global genome nucleotide-excision repair|chromatin silencing at rDNA|Unknown|snoRNA 3'-end processing|transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|chromatin binding|TFIIF-class binding transcription factor activity|RNA polymerase II core binding|RNA polymerase II transcription factor binding transcription factor activity	transcriptionally active chromatin|nucleus|Cdc73/Paf1 complex
YHR031C	YHR031C	RRM3	hom	Verified	1.80366521457875	0.0356419029311407	no	268	0.0484964755294081	225	NA	FT	RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION	NUCLEUS|CHROMOSOME		DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p	mitochondrial genome maintenance|replication fork progression beyond termination site|DNA replication	ATP-dependent DNA helicase activity|DNA helicase activity	nuclear telomeric heterochromatin|replication fork
YOR186W_p	YOR186W	YOR186W	hom	Uncharacterized	1.80256135179979	0.0357285656465417	no	269	0.0315227339326122	179	NA					Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent; YOR186W has a paralog, YLR297W, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YDR484W	YDR484W	VPS52	hom	Verified	1.79629231977588	0.0362240193435298	no	270	0.0873169757609118	313	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	GOLGI APPARATUS|CYTOSKELETON		Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin	actin filament-based process|Golgi to vacuole transport|retrograde transport, endosome to Golgi	protein binding	Golgi apparatus|GARP complex
YLR247C	YLR247C	IRC20	hom	Verified	1.7932545824708	0.0364661129996705	no	271	0.0226318199298321	137	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION		Putative helicase; localizes to the mitochondrion and the nucleus; YLR247C is not an essential gene; null mutant displays increased levels of spontaneous Rad52p foci	double-strand break repair via synthesis-dependent strand annealing	helicase activity	mitochondrion|nucleus
YNL157W	YNL157W	IGO1	hom	Verified	1.79131325794252	0.0366215198866189	no	272	0.0136833253759047	106	NA	FT		NUCLEUS		Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; similar to Igo2p	mRNA stabilization	molecular_function	nucleus|cytoplasmic mRNA processing body|cytoplasm
YER056C	YER056C	FCY2	hom	Verified	1.78948898016238	0.036768050319499	no	273	0.0227087834687997	125	NA	FT		PLASMA MEMBRANE		Purine-cytosine permease; mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation; relative distribution to the vacuole increases upon DNA replication stress	cytosine transport|cytidine transport|purine nucleobase transport|transmembrane transport	nucleobase transmembrane transporter activity|cytidine transmembrane transporter activity	integral to membrane|plasma membrane
YDR036C	YDR036C	EHD3	hom	Verified	1.78887271013408	0.0368176588437285	no	274	0.0239461421207607	145	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis	fatty acid beta-oxidation|biological_process	3-hydroxyisobutyryl-CoA hydrolase activity	mitochondrion
YBL057C	YBL057C	PTH2	hom	Verified	1.78884024251894	0.0368202739398527	no	275	0.0452452332930174	223	NA	FT	PROTEOLYSIS	MITOCHONDRION		One of two (see also PTH1) mitochondrially-localized peptidyl-tRNA hydrolases; negatively regulates the ubiquitin-proteasome pathway via interactions with ubiquitin-like ubiquitin-associated proteins; dispensable for cell growth	negative regulation of proteasomal ubiquitin-dependent protein catabolic process	aminoacyl-tRNA hydrolase activity	mitochondrial outer membrane|mitochondrion|cytoplasm
YEL057C_p	YEL057C	YEL057C	hom	Uncharacterized	1.78541379193547	0.0370971115920435	no	276	0.0223506463540946	119	NA					Protein of unknown function involved in telomere maintenance; target of UME6 regulation	biological_process	molecular_function	cellular_component
YLR087C	YLR087C	CSF1	hom	Verified	1.77958496347771	0.0375719544109952	no	277	0.0956578412560709	411	NA	FF|FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	fermentation	molecular_function	mitochondrion
YKR048C	YKR048C	NAP1	hom	Verified	1.77805586461612	0.0376973401009436	no	278	0.0390220582524541	249	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION	NUCLEUS|SITE OF POLARIZED GROWTH|CHROMOSOME		Protein that interacts with mitotic cyclin Clb2p; required for the regulation of microtubule dynamics during mitosis; controls bud morphogenesis; involved in the transport of H2A and H2B histones to the nucleus; phosphorylated by CK2; protein abundance increases in response to DNA replication stress	budding cell bud growth|M phase of mitotic cell cycle|nucleosome disassembly|protein import into nucleus|nucleosome assembly	cyclin binding|histone binding	nucleus|nuclear nucleosome|cytoplasm
YML055W	YML055W	SPC2	hom	Verified	1.77683718050445	0.0377975162862455	no	279	0.0508422645822026	255	NA	FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC25	signal peptide processing|protein targeting to ER	peptidase activity	signal peptidase complex
YJR078W	YJR078W	BNA2	hom	Verified	1.77639669476564	0.0378337777539791	no	280	0.0231806614808836	143	NA	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for de novo biosynthesis of NAD from tryptophan via kynurenine; interacts genetically with telomere capping gene CDC13; regulated by Hst1p and Aftp	de novo NAD biosynthetic process from tryptophan	tryptophan 2,3-dioxygenase activity|indoleamine 2,3-dioxygenase activity	cytoplasm
YLR244C	YLR244C	MAP1	hom	Verified	1.7714071105763	0.0382465135090636	no	281	0.0488324401343561	209	NA	FT	PROTEOLYSIS		RIBOSOME	Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p	negative regulation of gene expression|protein initiator methionine removal involved in protein maturation	metalloaminopeptidase activity|mRNA binding	cytosolic ribosome
YLR170C	YLR170C	APS1	hom	Verified	1.76328823273334	0.0389259444727235	no	282	0.0472678001569923	239	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex	Golgi to vacuole transport|vesicle-mediated transport	clathrin binding	AP-1 adaptor complex
YBL024W	YBL024W	NCL1	hom	Verified	1.76303448169258	0.0389473370952007	no	283	0.0652379160088287	240	NA	FT	RNA PROCESSING	NUCLEUS		S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase, methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; increases proportion of tRNALeu(CAA) with m5C at wobble position in response to hydrogen peroxide, causing selective translation of mRNA from genes enriched in TTG codon; loss of NCL1 confers hypersensitivity to oxidative stress; similar to Nop2p and human proliferation associated nucleolar protein p120	tRNA methylation	tRNA (cytosine-5-)-methyltransferase activity	nucleus
YMR159C	YMR159C	ATG16	hom	Verified	1.76017659219301	0.0391889347702468	no	284	0.0381306127078683	202	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Conserved protein involved in autophagy; interacts with Atg12p-Atg5p conjugates to form Atg12p-Atg5p-Atg16p multimers, which localize to the pre-autophagosomal structure and are required for autophagy; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress	C-terminal protein lipidation|piecemeal microautophagy of nucleus|mitochondrion degradation|macroautophagy|CVT pathway	protein binding, bridging|Atg8 ligase activity	Atg12-Atg5-Atg16 complex|pre-autophagosomal structure
YJL056C	YJL056C	ZAP1	hom	Verified	1.75905309754216	0.0392842451485733	no	285	0.0938776417607728	369	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Zinc-regulated transcription factor; binds to zinc-responsive promoters to induce transcription of certain genes in presence of zinc, represses other genes in low zinc; regulates its own transcription; contains seven zinc-finger domains	regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding RNA polymerase II transcription factor activity|RNA polymerase II regulatory region sequence-specific DNA binding|zinc ion binding	nucleus
YPR167C	YPR167C	MET16	hom	Verified	1.7479046553564	0.0402402693027006	no	286	0.0369895145010127	180	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS			3'-phosphoadenylsulfate reductase, reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism	sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)|sulfur amino acid metabolic process	phosphoadenylyl-sulfate reductase (thioredoxin) activity	cytoplasm
YIL029C_p	YIL029C	YIL029C	hom	Uncharacterized	1.74647005581712	0.0403646529647406	no	287	0.0522112376979398	262	NA					Putative protein of unknown function; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YIL029C has paralog YPR071W	biological_process	molecular_function	integral to membrane
YDL010W	YDL010W	GRX6	hom	Verified	1.74610506149326	0.0403963487324689	no	288	0.0377984655721614	168	NA	FT	RESPONSE TO OXIDATIVE STRESS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Cis-golgi localized monothiol glutaredoxin, binds Fe-S cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; GRX6 has a paralog, GRX7, that arose from the whole genome duplication	cellular response to oxidative stress	glutathione-disulfide reductase activity|iron ion binding|protein homodimerization activity|2 iron, 2 sulfur cluster binding	integral to membrane|Golgi apparatus|Golgi lumen|endoplasmic reticulum membrane|fungal-type vacuole|cis-Golgi network
YLR083C	YLR083C	EMP70	hom	Verified	1.74393628109695	0.0405851006515063	no	289	0.058727568760105	195	NA	FT	VESICLE-MEDIATED TRANSPORT|ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT			Protein with a role in cellular adhesion, filamentous growth, and endosome-to-vacuole sorting; similar to Tmn2p and Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments	cellular copper ion homeostasis|vacuolar transport|pseudohyphal growth|endosomal transport|invasive growth in response to glucose limitation	molecular_function	endosome|fungal-type vacuole membrane|integral to membrane
YHR204W	YHR204W	MNL1	hom	Verified	1.74315458176128	0.0406533082769334	no	290	0.0364797732084846	238	NA	FT	PROTEOLYSIS	ENDOPLASMIC RETICULUM		Alpha-1,2-specific exomannosidase of the endoplasmic reticulum; in complex with Pdi1p, generates a Man7GlcNac2 oligosaccharide signal on glycoproteins destined for ubiquitin-proteasome degradation	ER-associated protein catabolic process	carbohydrate binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	endoplasmic reticulum lumen
YMR029C	YMR029C	FAR8	hom	Verified	1.74004242419749	0.0409257844384406	no	291	0.0299212678373431	170	NA	FT	CELL CYCLE|SIGNALING	ENDOPLASMIC RETICULUM		Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p	re-entry into mitotic cell cycle after pheromone arrest	molecular_function	cellular_component
YOR258W	YOR258W	HNT3	hom	Verified	1.73697881238466	0.0411954553858982	no	292	0.0647512092497911	292	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		DNA 5' AMP hydrolase involved in DNA repair; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins; homolog of Aprataxin, a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxia; relative distribution to nuclear foci decreases upon DNA replication stress	response to DNA damage stimulus	DNA 5'-adenosine monophosphate hydrolase activity	nucleus|cytoplasm
YKL025C	YKL025C	PAN3	hom	Verified	1.73095492710194	0.0417299019083946	no	293	0.0592116437263546	271	NA	FT	RNA PROCESSING|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION			Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes	DNA repair|mRNA 3'-end processing|postreplication repair	poly(A)-specific ribonuclease activity	PAN complex|cytoplasm
YKL217W	YKL217W	JEN1	hom	Verified	1.73085890772705	0.0417384661200247	no	294	0.041311827734837	194	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION|PLASMA MEMBRANE		Monocarboxylate/proton symporter of the plasma membrane; transport activity is dependent on the pH gradient across the membrane; mediates high-affinity uptake of carbon sources lactate, pyuvate, and acetate, and also of the micronutrient selenite, whose structure mimics that of monocarboxylates; expression and localization are tightly regulated, with transcription repression, mRNA degradation, and protein endocytosis and degradation all occurring in the presence of glucose	plasma membrane lactate transport|plasma membrane selenite transport|plasma membrane pyruvate transport	selenite:hydrogen symporter activity|secondary active monocarboxylate transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YLR191W	YLR191W	PEX13	hom	Verified	1.73065161288127	0.0417569601271497	no	295	0.0496008316268355	244	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PEROXISOME ORGANIZATION			Integral peroxisomal membrane protein required for translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p	protein import into peroxisome matrix, docking	protein binding, bridging	peroxisomal membrane
YNL072W	YNL072W	RNH201	hom	Verified	1.73031834803215	0.0417867065789834	no	296	0.104190765579703	425	NA	FT		NUCLEUS		Ribonuclease H2 catalytic subunit, removes RNA primers during Okazaki fragment synthesis and errant ribonucleotides misincorporated during DNA replication; homolog of RNAse HI; related to human AGS4 which causes Aicardi-Goutieres syndrome	DNA replication, removal of RNA primer	ribonuclease H activity	ribonuclease H2 complex|nucleus
YKR078W	YKR078W	YKR078W	hom	Verified	1.72798637815751	0.0419953332933564	no	297	0.0451025314826142	231	NA					Cytoplasmic protein of unknown function, has similarity to Vps5p; potential Cdc28p substrate; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P)	biological_process	phosphatidylinositol-3-phosphate binding	cytoplasm
YDR346C	YDR346C	SVF1	hom	Verified	1.72363914823602	0.0423865033134424	no	298	0.0598106261855408	228	NA	FT	RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis; mutant has increased aneuploidy tolerance	cellular response to oxidative stress	molecular_function	nucleus|cytoplasm
YER121W_p	YER121W	YER121W	hom	Uncharacterized	1.72355258605667	0.04239432212918	no	299	0.0542190036179652	214	NA					Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy	biological_process	molecular_function	cellular_component
YOL153C	YOL153C	YOL153C	hom	pseudogene	1.71822989806831	0.0428773450774262	no	300	0.0238400400795957	122	NA					Hypothetical protein	biological_process	molecular_function	cellular_component
YGR231C	YGR231C	PHB2	hom	Verified	1.71365456187618	0.0432960932646652	no	301	0.0553039049784939	211	NA	FT	PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation	mitochondrion inheritance|protein folding|negative regulation of proteolysis|replicative cell aging	molecular_function	mitochondrion|mitochondrial inner membrane
YER040W	YER040W	GLN3	hom	Verified	1.70953363613321	0.0436760733195664	no	302	0.0419087607281388	253	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR), localization and activity regulated by quality of nitrogen source	nitrogen catabolite activation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	cytosol|nucleus
YOR284W	YOR284W	HUA2	hom	Verified	1.70898619591772	0.0437267532519266	no	303	0.0397049885969265	175	NA					Cytoplasmic protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly	biological_process	molecular_function	cytoplasm
YDR300C	YDR300C	PRO1	hom	Verified	1.70183978465133	0.0443927031123423	no	304	0.0469463048896029	202	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Gamma-glutamyl kinase; catalyzes the first step in proline biosynthesis; PRO1 has a paralog, YHR033W, that arose from the whole genome duplication	proline biosynthetic process	glutamate 5-kinase activity	cytoplasm
YDL192W	YDL192W	ARF1	hom	Verified	1.6989675640662	0.0446626476499592	no	305	0.0662273287990971	315	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|RESPONSE TO NUTRIENT LEVELS	GOLGI APPARATUS		ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication	ER to Golgi vesicle-mediated transport|Golgi to plasma membrane transport|intra-Golgi vesicle-mediated transport|macroautophagy	GTPase activity	cytosol|Golgi-associated vesicle
YPR066W	YPR066W	UBA3	hom	Verified	1.69881697826367	0.0446768367920742	no	306	0.0525714882947471	225	NA					Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern	protein neddylation	NEDD8 activating enzyme activity	cytoplasm
YOR032C	YOR032C	HMS1	hom	Verified	1.69420137170096	0.0451135121429002	no	307	0.0545765281062178	239	NA	FT		NUCLEUS		Basic helix-loop-helix (bHLH) protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant	pseudohyphal growth	sequence-specific DNA binding transcription factor activity	cellular_component
YKL215C	YKL215C	OXP1	hom	Verified	1.69033247083279	0.0454821831604733	no	308	0.0334795699561388	146	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			5-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress	glutathione metabolic process	5-oxoprolinase (ATP-hydrolyzing) activity	cytoplasm
YKR080W	YKR080W	MTD1	hom	Verified	1.68322293514263	0.0461659712508067	no	309	0.0529871983669006	218	NA	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	NUCLEUS		NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline	folic acid-containing compound biosynthetic process|one-carbon metabolic process|purine nucleobase biosynthetic process	methylenetetrahydrofolate dehydrogenase (NAD+) activity	cytosol
YDL168W	YDL168W	SFA1	hom	Verified	1.67892201967026	0.0465836212321799	no	310	0.0713690653043753	250	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Bifunctional alcohol dehydrogenase and formaldehyde dehydrogenase; formaldehyde dehydrogenase activity is glutathione-dependent; functions in formaldehyde detoxification and formation of long chain and complex alcohols, regulated by Hog1p-Sko1p; protein abundance increases in response to DNA replication stress	furaldehyde metabolic process|formaldehyde catabolic process|amino acid catabolic process to alcohol via Ehrlich pathway	S-(hydroxymethyl)glutathione dehydrogenase activity|hydroxymethylfurfural reductase (NADH) activity|alcohol dehydrogenase (NAD) activity	mitochondrion|cytoplasm
YHR012W	YHR012W	VPS29	hom	Verified	1.67872990555776	0.0466023474149857	no	311	0.0620096930225026	345	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM		Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval	retrograde transport, endosome to Golgi	protein transporter activity	endosome|retromer complex, inner shell|retromer complex
YJL060W	YJL060W	BNA3	hom	Verified	1.6786924374302	0.0466060002972159	no	312	0.0444223241302936	246	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Kynurenine aminotransferase, catalyzes formation of kynurenic acid from kynurenine; potential Cdc28p substrate	kynurenic acid biosynthetic process	arylformamidase activity|kynurenine-oxoglutarate transaminase activity	mitochondrion|cytoplasm
YLR028C	YLR028C	ADE16	hom	Verified	1.67396804843085	0.0470684395151981	no	313	0.0392085158602174	145	NA	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE16 has a paralog, ADE17, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine	ascospore formation|'de novo' IMP biosynthetic process|purine nucleotide biosynthetic process|aerobic respiration	phosphoribosylaminoimidazolecarboxamide formyltransferase activity|IMP cyclohydrolase activity	cytosol
YNL001W	YNL001W	DOM34	hom	Verified	1.67110087782704	0.0473508770152673	no	314	0.0520735604963925	244	NA	FT	CELL CYCLE|TRANSLATION|CELL DIVISION			Protein that facilitates ribosomal subunit dissociation; acts when translation is stalled, with binding partner Hbs1p; required for RNA cleavage in no-go decay, but reports conflict on endonuclease activity; Pelota ortholog; protein abundance increases in response to DNA replication stress; DOM34 has a paralog, YCL001W-B, that arose from the whole genome duplication	nuclear-transcribed mRNA catabolic process, no-go decay|ribosome disassembly|nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay|nonfunctional rRNA decay	ribosome binding|endoribonuclease activity	cytoplasm
YBR095C	YBR095C	RXT2	hom	Verified	1.66987898222495	0.0474716547531062	no	315	0.0731902711671633	329	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Subunit of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth	conjugation with cellular fusion|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of transcription from RNA polymerase II promoter|negative regulation of chromatin silencing at telomere|negative regulation of chromatin silencing at rDNA|invasive growth in response to glucose limitation	histone deacetylase activity	Rpd3L-Expanded complex|nucleus|Rpd3L complex
YMR080C	YMR080C	NAM7	hom	Verified	1.66009009943565	0.0484481641694094	no	316	0.0621513149295911	220	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|RNA LOCALIZATION|GENE SILENCING	NUCLEUS		ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance; forms cytoplasmic foci upon DNA replication stress	nuclear-transcribed mRNA catabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|intracellular mRNA localization|translational frameshifting|regulation of translational termination|chromatin silencing at silent mating-type cassette|protein ubiquitination	RNA-dependent ATPase activity|ATP-dependent RNA helicase activity|nucleic acid binding	mitochondrion|polysome|cytoplasm
YPR116W	YPR116W	RRG8	hom	Verified	1.65925901530061	0.0485318050777282	no	317	0.0505510573857801	227	NA	FT	MITOCHONDRION ORGANIZATION	MITOCHONDRION		Putative protein of unknown function, required for mitochondrial genome maintenance; null mutation results in a decrease in plasma membrane electron transport	mitochondrial genome maintenance	molecular_function	mitochondrion
YHR142W	YHR142W	CHS7	hom	Verified	1.65469928887167	0.0489927557016558	no	318	0.142710714285049	530	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein of unknown function; may be involved in chitin biosynthesis by regulation of Chs3p export from the ER; relocalizes from bud neck to ER upon DNA replication stress	protein folding|ER to Golgi vesicle-mediated transport|fungal-type cell wall chitin biosynthetic process	unfolded protein binding	integral to membrane|endoplasmic reticulum membrane
YJL172W	YJL172W	CPS1	hom	Verified	1.65402336876959	0.0490613823331492	no	319	0.0613620106158297	198	NA	FT	PROTEOLYSIS			Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions	nitrogen compound metabolic process|proteolysis involved in cellular protein catabolic process	carboxypeptidase activity	fungal-type vacuole lumen
YCL047C	YCL047C	POF1	hom	Verified	1.65133385888605	0.049335211092428	no	320	0.0597733781623811	267	NA	FT	PROTEOLYSIS			ATPase involved in the protein quality control and filamentation pathways; interacts physically with Kss1p and suppresses the filamentation defect of a kss1 deletion; also interacts with Ubc7p	pseudohyphal growth|ER-associated protein catabolic process|invasive growth in response to glucose limitation	ATPase activity	cellular_component
YIL002C	YIL002C	INP51	hom	Verified	1.64860205399424	0.0496145938341903	no	321	0.0735217850289039	324	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION	CYTOSKELETON		Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in phosphatidylinositol 4,5-bisphosphate homeostasis and in endocytosis; null mutation confers cold-tolerant growth	phosphatidylinositol dephosphorylation	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	membrane|cytoplasm
YBR266C_d	YBR266C	SLM6	hom	Dubious	1.63104774479116	0.0514401227482965	no	322	0.0560279435084758	260	NA					Protein with a potential role in actin cytoskeleton organization; gene exhibits synthetic genetic interaction with MSS4 encoding phosphatidylinositol 4-phosphate kinase	Unknown	Unknown	Unknown
YDR452W	YDR452W	PPN1	hom	Verified	1.62622864304067	0.0519505125308514	no	323	0.0791988796280418	190	NA	FT		NUCLEUS		Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress	polyphosphate catabolic process|polyphosphate metabolic process	endopolyphosphatase activity|exopolyphosphatase activity	fungal-type vacuole membrane|nucleus
YOR298C-A	YOR298C-A	MBF1	hom	Verified	1.62485085293081	0.0520971712113306	no	324	0.0304420164876755	124	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS|MITOCHONDRION		Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress	positive regulation of transcription from RNA polymerase II promoter	transcription coactivator activity	mitochondrion|nucleus
YPL106C	YPL106C	SSE1	hom	Verified	1.62434939667405	0.0521506302153423	no	325	0.064303898538544	292	NA					ATPase component of the heat shock protein Hsp90 chaperone complex; binds unfolded proteins; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm; SSE1 has a paralog, SSE2, that arose from the whole genome duplication	protein folding|protein refolding	peptide binding|adenyl-nucleotide exchange factor activity|ATP binding	polysome|cytoplasm
YMR110C	YMR110C	HFD1	hom	Verified	1.62308404753394	0.0522857196370683	no	326	0.0349746985519528	212	NA	FT	OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder	cellular aldehyde metabolic process	3-chloroallyl aldehyde dehydrogenase activity	mitochondrial outer membrane|endosome|mitochondrion|lipid particle|integral to mitochondrial outer membrane
YDR363W	YDR363W	ESC2	hom	Verified	1.6229856551576	0.0522962356982837	no	327	0.0644004041883913	261	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|GENE SILENCING	NUCLEUS		Sumo-like domain protein; prevents accumulation of toxic intermediates during replication-associated recombinational repair; roles in silencing, lifespan, chromatid cohesion and the intra-S-phase DNA damage checkpoint; RENi family member	intra-S DNA damage checkpoint|double-strand break repair via homologous recombination|chromatin silencing at silent mating-type cassette|mitotic sister chromatid cohesion	molecular_function	nucleus
YHL031C	YHL031C	GOS1	hom	Verified	1.62202198336242	0.0523993206047638	no	328	0.110176240388406	455	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28	Golgi vesicle transport|vesicle fusion	SNAP receptor activity	SNARE complex|integral to membrane|Golgi medial cisterna
YAL007C	YAL007C	ERP2	hom	Verified	1.62176358249911	0.0524269894064231	no	329	0.0514307749751206	244	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein that forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles	ER to Golgi vesicle-mediated transport	molecular_function	ER to Golgi transport vesicle
YGL223C	YGL223C	COG1	hom	Verified	1.62164384291758	0.0524398146993682	no	330	0.0952057009127761	344	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments	retrograde transport, vesicle recycling within Golgi|intra-Golgi vesicle-mediated transport|CVT pathway	molecular_function	Golgi transport complex
YHL045W_d	YHL045W	YHL045W	hom	Dubious	1.6104257196713	0.053652474740068	no	331	0.0484626092898684	173	NA					Putative protein of unknown function; not an essential gene	Unknown	Unknown	Unknown
YHR029C	YHR029C	YHI9	hom	Verified	1.60960654282935	0.0537418894781997	no	332	0.0634642970017288	254	NA	FT	SIGNALING			Protein of unknown function; null mutant is defective in unfolded protein response; possibly involved in a membrane regulation metabolic pathway; member of the PhzF superfamily, though most likely not involved in phenazine production	endoplasmic reticulum unfolded protein response	molecular_function	cellular_component
YBR213W	YBR213W	MET8	hom	Verified	1.60923876677608	0.0537820713135638	no	333	0.0637987823413027	272	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM			Bifunctional dehydrogenase and ferrochelatase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis	siroheme biosynthetic process|sulfate assimilation	precorrin-2 dehydrogenase activity|ferrochelatase activity	cellular_component
YBL021C	YBL021C	HAP3	hom	Verified	1.60854556660586	0.053857872451128	no	334	0.0580888747561924	174	NA	FT	TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding	carbon catabolite activation of transcription from RNA polymerase II promoter|regulation of cellular respiration	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	CCAAT-binding factor complex
YML053C_p	YML053C	YML053C	hom	Uncharacterized	1.60833296616303	0.0538811371602356	no	335	0.0522417376225756	188	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene	biological_process	molecular_function	nucleus|cytoplasm
YGR157W	YGR157W	CHO2	hom	Verified	1.60818307414866	0.0538975445145684	no	336	0.0607638713928628	232	NA	FT	LIPID METABOLISM			Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis	phosphatidylcholine biosynthetic process	phosphatidylethanolamine N-methyltransferase activity	integral to membrane|endoplasmic reticulum
YGR068C	YGR068C	ART5	hom	Verified	1.60781306267209	0.0539380633364814	no	337	0.0552176223133819	253	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION			Protein proposed to regulate the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membrane	ubiquitin-dependent endocytosis	ubiquitin protein ligase binding	cellular_component
YDR378C	YDR378C	LSM6	hom	Verified	1.60051639296285	0.0547420366197948	no	338	0.0652558903825558	325	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA	nuclear-transcribed mRNA catabolic process|mRNA splicing, via spliceosome|maturation of SSU-rRNA	RNA binding	U6 snRNP|nucleolus|small nucleolar ribonucleoprotein complex|U4/U6 x U5 tri-snRNP complex|cytoplasmic mRNA processing body
YPL023C	YPL023C	MET12	hom	Verified	1.59164352754559	0.0557324119495601	no	339	0.0600298361118951	279	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS			Protein with methylenetetrahydrofolate reductase (MTHFR) activity in vitro; null mutant has no phenotype and is prototrophic for methionine; MET13 encodes major isozyme of MTHFR	biological_process	methylenetetrahydrofolate reductase (NADPH) activity	cellular_component
YPR001W	YPR001W	CIT3	hom	Verified	1.59032337106659	0.0558809666083614	no	340	0.0694736174900478	303	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate	propionate catabolic process, 2-methylcitrate cycle|propionate metabolic process|tricarboxylic acid cycle	2-methylcitrate synthase activity|citrate (Si)-synthase activity	mitochondrion
YOL002C	YOL002C	IZH2	hom	Verified	1.56919303190039	0.0583014836856701	no	341	0.0548265168468624	298	NA	FT	KETONE METABOLISM|LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc	response to zinc ion|cellular zinc ion homeostasis|response to toxin|cellular lipid metabolic process	protein binding|metal ion binding	integral to membrane|plasma membrane|membrane
YOR273C	YOR273C	TPO4	hom	Verified	1.56728783183879	0.0585237141481541	no	342	0.0936709249213684	418	NA	FF|FT		PLASMA MEMBRANE		Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane	spermidine transport|spermine transport	spermidine transmembrane transporter activity|spermine transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|plasma membrane
YLR384C	YLR384C	IKI3	hom	Verified	1.56614118263564	0.0586577843563712	no	343	0.0536713571693997	277	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)	regulation of transcription from RNA polymerase II promoter|tRNA wobble uridine modification	molecular_function	Elongator holoenzyme complex|nucleus|cytoplasm
YLR423C	YLR423C	ATG17	hom	Verified	1.56383751771594	0.0589278655230739	no	344	0.0667255811506444	347	NA	FT	MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION			Scaffold protein responsible for phagophore assembly site organization; regulatory subunit of an autophagy-specific complex that includes Atg1p and Atg13p; stimulates Atg1p kinase activity; human ortholog RB1CC1/FIP200 interacts with p53, which inhibits autophagy in human cells	piecemeal microautophagy of nucleus|mitochondrion degradation|peroxisome degradation|activation of protein kinase activity|autophagic vacuole assembly	protein kinase activator activity|protein complex scaffold	pre-autophagosomal structure|Atg1p signaling complex
YKR035C_d	YKR035C	OPI8	hom	Dubious	1.56335326560851	0.0589847630490919	no	345	0.0925458435526897	360	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene DID2/YKR035W-A	Unknown	Unknown	Unknown
YPL046C	YPL046C	ELC1	hom	Verified	1.56152562586621	0.0591998911807173	no	346	0.0428912451559365	241	NA	FT	RESPONSE TO DNA DAMAGE|PROTEOLYSIS	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Elongin C, conserved among eukaryotes; forms a complex with Cul3p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; plays a role in global genomic repair	global genome nucleotide-excision repair|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity	elongin complex|Cul3-RING ubiquitin ligase complex
YER005W	YER005W	YND1	hom	Verified	1.5583913804364	0.0595702493341162	no	347	0.0598963719542022	289	NA	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	GOLGI APPARATUS		Apyrase with wide substrate specificity, helps prevent inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates that inhibit glycotransferases; partially redundant with Gda1p; mediates adenovirus E4orf4-induced toxicity	protein glycosylation	nucleoside-triphosphatase activity|nucleoside-diphosphatase activity	COPI-coated vesicle|Golgi apparatus|membrane|Golgi membrane
YCL014W	YCL014W	BUD3	hom	Verified	1.55526550879736	0.0599414241268933	no	348	0.0558621685103303	237	NA	FT	CELL CYCLE|SIGNALING|CELL DIVISION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding	cellular bud site selection|axial cellular bud site selection|cytokinesis	molecular_function	cellular bud neck contractile ring|cellular bud neck
YCL074W	YCL074W	YCL074W	hom	pseudogene	1.55203904366576	0.0603264408664715	no	349	0.0559212700609932	202	NA	FT		NUCLEUS		Pseudogene: encodes fragment of Ty Pol protein	transposition, RNA-mediated	ribonuclease activity|peptidase activity|RNA binding|RNA-directed DNA polymerase activity|DNA-directed DNA polymerase activity	retrotransposon nucleocapsid
YBR074W_p	YBR074W	YBR074W	hom	Uncharacterized	1.55172243058061	0.0603643266159578	no	350	0.0728687333953612	313	NA	FT	PROTEOLYSIS			Putative metalloprotease	biological_process	molecular_function	cellular_component
YGR167W	YGR167W	CLC1	hom	Verified	1.55076270854798	0.060479280203365	no	351	0.0944422989624972	443	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS|PLASMA MEMBRANE		Clathrin light chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function; two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component; YGR167W	endocytosis|vesicle-mediated transport	structural molecule activity	clathrin vesicle coat
YEL043W	YEL043W	YEL043W	hom	Verified	1.54820274994244	0.0607867447708264	no	352	0.059616645215166	286	NA	FT		ENDOPLASMIC RETICULUM		Predicted cytoskeleton protein involved in intracellular signalling based on quantitative analysis of protein-protein interaction maps; may interact with ribosomes, based on co-purification studies; contains fibronectin type III domain fold	biological_process	molecular_function	ribosome|endoplasmic reticulum
YGR162W	YGR162W	TIF4631	hom	Verified	1.54708952031519	0.0609208303038993	no	353	0.0742149589871042	330	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION	MITOCHONDRION	RIBOSOME	Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication	translational initiation|ribosomal large subunit biogenesis|stress granule assembly	translation initiation factor activity	mitochondrion|ribosome|eukaryotic translation initiation factor 4F complex|cytoplasmic stress granule
YPR109W_p	YPR109W	YPR109W	hom	Uncharacterized	1.54703322600034	0.0609276169411689	no	354	0.0746119639436612	293	NA	FT	CELL CYCLE			Predicted membrane protein; dipoid deletion strain has high budding index	biological_process	molecular_function	cellular_component
YML128C	YML128C	MSC1	hom	Verified	1.54463259164649	0.0612175790934215	no	355	0.0703869033078758	312	NA	FT	CELL CYCLE	ENDOPLASMIC RETICULUM|MITOCHONDRION		Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated	reciprocal meiotic recombination	molecular_function	mitochondrion|endoplasmic reticulum|plasma membrane
YOL064C	YOL064C	MET22	hom	Verified	1.53819490030978	0.0620004837653962	no	356	0.0860312340189115	341	NA	FT	KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Bisphosphate-3'-nucleotidase, involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway	methionine biosynthetic process|hyperosmotic salinity response|sulfate assimilation	3'(2'),5'-bisphosphate nucleotidase activity	cellular_component
YPR140W	YPR140W	TAZ1	hom	Verified	1.53817886420575	0.0620024436678557	no	357	0.0583750556678176	202	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|LIPID METABOLISM|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; human ortholog tafazzin is implicated in Barth syndrome	cardiolipin acyl-chain remodeling|mitochondrial ATP synthesis coupled electron transport|protein complex assembly|inner mitochondrial membrane organization|cardiolipin metabolic process|phospholipid biosynthetic process	1-acylglycerophosphocholine O-acyltransferase activity	mitochondrial outer membrane|mitochondrion|mitochondrial inner membrane|integral to mitochondrial outer membrane
YNL304W	YNL304W	YPT11	hom	Verified	1.53633961757129	0.0622275538545677	no	358	0.0662204254724034	242	NA	FT	SIGNALING|MITOCHONDRION ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH		Rab family GTPase that interacts with the C-terminal tail domain of Myo2p; mediates distribution of mitochondria and endoplasmic reticuli to daughter cells	mitochondrion inheritance|endoplasmic reticulum inheritance|Golgi inheritance|Golgi localization	GTPase activity	incipient cellular bud site|endoplasmic reticulum|cellular bud neck|cellular bud tip
YKL168C	YKL168C	KKQ8	hom	Verified	1.53622034838054	0.062242173503192	no	359	0.0489047335702603	206	NA	FT	PROTEIN PHOSPHORYLATION			Putative serine/threonine protein kinase with unknown cellular role; KKQ8 has a paralog, HAL5, that arose from the whole genome duplication	biological_process	protein kinase activity	cytoplasm
YKR104W	YKR104W	YKR104W	hom	Verified	1.5327315539848	0.0626710055922799	no	360	0.061504139766903	297	NA	FT	NUCLEOTIDE METABOLISM			Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; contains a stop codon in S288C; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds	transport	ATPase activity, coupled to transmembrane movement of substances	integral to membrane|membrane
YLR248W	YLR248W	RCK2	hom	Verified	1.52959111946314	0.0630589844903613	no	361	0.0672347805973815	295	NA	FT	CELL CYCLE|SIGNALING|PROTEIN PHOSPHORYLATION|RESPONSE TO OXIDATIVE STRESS			Protein kinase involved in response to oxidative and osmotic stress; identified as suppressor of S. pombe cell cycle checkpoint mutations; similar to CaM (calmodulin) kinases; RCK2 has a paralog, RCK1, that arose from the whole genome duplication	cellular response to oxidative stress|protein phosphorylation|osmosensory signaling pathway|regulation of meiosis	protein serine/threonine kinase activity|protein kinase activity	cytoplasm
YOR132W	YOR132W	VPS17	hom	Verified	1.52957110000939	0.0630614637420328	no	362	0.0618341804556868	326	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM		Subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde protein transport; peripheral membrane protein that assembles onto the membrane with Vps5p to promote vesicle formation; required for recruiting the retromer complex to the endosome membranes	retrograde transport, endosome to Golgi	protein transporter activity|phosphatidylinositol-3-phosphate binding	endosome|retromer complex, outer shell|retromer complex
YGL053W	YGL053W	PRM8	hom	Verified	1.52420223040149	0.0637291005237128	no	363	0.0541486863756786	249	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Pheromone-regulated protein with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; forms a complex with Prp9p in the ER; member of DUP240 gene family	biological_process	molecular_function	integral to membrane|endoplasmic reticulum|plasma membrane
YJL121C	YJL121C	RPE1	hom	Verified	1.51978169097521	0.0642829260951913	no	364	0.08468647176249	351	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS			D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress	pentose-phosphate shunt	ribulose-phosphate 3-epimerase activity	cytosol
YBR065C	YBR065C	ECM2	hom	Verified	1.51908627282947	0.0643703907698524	no	365	0.0573492513944609	248	NA	FT	RNA PROCESSING	NUCLEUS		Pre-mRNA splicing factor, facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p	mRNA splicing, via spliceosome	molecular_function	nucleus
YLR382C	YLR382C	NAM2	hom	Verified	1.51207300603476	0.0652576455630296	no	366	0.0809175600821343	318	NA	FT	KETONE METABOLISM|RNA PROCESSING|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial leucyl-tRNA synthetase, also has a direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance	Group I intron splicing|leucyl-tRNA aminoacylation|mitochondrial translation	mRNA binding|leucine-tRNA ligase activity	mitochondrion
YLR418C	YLR418C	CDC73	hom	Verified	1.51184807851465	0.0652862575955344	no	367	0.147853507782211	564	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION	NUCLEUS|CHROMOSOME	RNA POL II, HOLOENZYME	Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; protein abundance increases in response to DNA replication stress	transcription elongation from RNA polymerase I promoter|negative regulation of DNA recombination|mRNA 3'-end processing|recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex|positive regulation of transcription elongation from RNA polymerase II promoter|Unknown|regulation of transcription-coupled nucleotide-excision repair|transcription elongation from RNA polymerase II promoter	chromatin binding|TFIIF-class binding transcription factor activity|RNA polymerase II core binding|RNA polymerase II transcription factor binding transcription factor activity	nucleus|transcriptionally active chromatin|Cdc73/Paf1 complex
YBL091C-A	YBL091C-A	SCS22	hom	Verified	1.51070545663943	0.0654317557778364	no	368	0.0640407234750805	298	NA	FT	LIPID METABOLISM			Protein involved in regulation of phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; similar to D. melanogaster inturned protein; SCS22 has a paralog, SCS2, that arose from the whole genome duplication	phospholipid biosynthetic process|chromatin silencing at telomere	molecular_function	cellular_component
YOL109W	YOL109W	ZEO1	hom	Verified	1.50659683386134	0.065957014731533	no	369	0.0709012711423112	288	NA	FT	CELL WALL ORG/BIOGENESIS	MITOCHONDRION|PLASMA MEMBRANE		Peripheral membrane protein of the plasma membrane that interacts with Mid2p; regulates the cell integrity pathway mediated by Pkc1p and Slt2p; the authentic protein is detected in a phosphorylated state in highly purified mitochondria	fungal-type cell wall organization|response to stress	molecular_function	mitochondrial outer membrane|mitochondrion|extrinsic to plasma membrane|plasma membrane
YBL017C	YBL017C	PEP1	hom	Verified	1.50351327960257	0.0663533675605392	no	370	0.0425937781117456	157	NA	FT	PROTEIN LOCALIZATION|VACUOLAR TRANSPORT	GOLGI APPARATUS		Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments	vacuolar transport|protein targeting to vacuole	signal sequence binding	integral to membrane|Golgi apparatus
YJL192C	YJL192C	SOP4	hom	Verified	1.50183024236777	0.0665704779046823	no	371	0.10684993881797	443	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		ER-membrane protein; suppressor of pma1-7, deletion of SOP4 slows down the export of wild-type Pma1p and Pma1-7 from the ER	ER to Golgi vesicle-mediated transport	molecular_function	integral to membrane|endoplasmic reticulum
YER068W	YER068W	MOT2	hom	Verified	1.50115662257587	0.0666575282011047	no	372	0.077067847444779	281	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications	deadenylation-independent decapping of nuclear-transcribed mRNA|positive regulation of transcription elongation from RNA polymerase II promoter|protein polyubiquitination|protein ubiquitination	ubiquitin-protein ligase activity|sequence-specific DNA binding	CCR4-NOT core complex|cytoplasm
YKL157W	YKL157W	APE2	hom	Verified	1.49495340995449	0.0674633008644269	no	373	0.0731809734443252	270	NA	FT	PROTEOLYSIS	MITOCHONDRION		Aminopeptidase yscII; may have a role in obtaining leucine from dipeptide substrates; APE2 has a paralog, AAP1, that arose from the whole genome duplication	peptide catabolic process	metalloaminopeptidase activity	mitochondrion|extracellular region|cell wall-bounded periplasmic space
YKR065C	YKR065C	PAM17	hom	Verified	1.49089332330849	0.0679947522968227	no	374	0.04833930758557	238	NA	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Constituent of the TIM23 complex; proposed alternatively to be a component of the import motor (PAM complex) or to interact with and modulate the core TIM23 (Translocase of the Inner mitochondrial Membrane) complex; protein abundance increases in response to DNA replication stress	protein import into mitochondrial matrix	molecular_function	mitochondrion|presequence translocase-associated import motor
YHR028C	YHR028C	DAP2	hom	Verified	1.48799710978789	0.0683758279218714	no	375	0.0875395361248306	313	NA	FT	PROTEOLYSIS			Dipeptidyl aminopeptidase, synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p	protein processing	dipeptidyl-peptidase activity	fungal-type vacuole membrane
YJR084W	YJR084W	YJR084W	hom	Verified	1.4827640006214	0.0690685618710427	no	376	0.049976919922579	227	NA	FT	RNA PROCESSING|SIGNALING	NUCLEUS|CHROMOSOME		Protein that forms a complex with Thp3p; may have a role in transcription elongation and/or mRNA splicing; identified as a COP9 signalosome component but phenotype and interactions suggest it may not be involved with the signalosome	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|mRNA splicing, via spliceosome	molecular_function	transcriptionally active chromatin
YMR171C	YMR171C	EAR1	hom	Verified	1.48236406417651	0.0691217252113267	no	377	0.0654155099531011	295	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT			Specificity factor required for Rsp5p-dependent ubiquitination and sorting of specific cargo proteins at the multivesicular body; mRNA is targeted to the bud via the mRNA transport system involving She2p	protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	molecular_function	endosome
YCL005W	YCL005W	LDB16	hom	Verified	1.47973344263876	0.069472198512258	no	378	0.0914386059775349	399	NA	FT		MITOCHONDRION		Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria	biological_process	molecular_function	mitochondrion|lipid particle
YBL062W_d	YBL062W	YBL062W	hom	Dubious	1.4776279219328	0.0697536982420403	no	379	0.0890204811599834	361	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR221W	YDR221W	GTB1	hom	Verified	1.47648609023598	0.069906723322865	no	380	0.0614774499105683	266	NA	FT	CARBOHYDRATE METABOLISM	ENDOPLASMIC RETICULUM		Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p; involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER; relocalizes from ER to cytoplasm upon DNA replication stress	polysaccharide biosynthetic process|protein N-linked glycosylation	alpha-glucosidase activity	glucosidase II complex|endoplasmic reticulum|endoplasmic reticulum lumen
YBR114W	YBR114W	RAD16	hom	Verified	1.47550257124141	0.070038738755941	no	381	0.0741958258808688	315	NA	FT	RESPONSE TO DNA DAMAGE|PROTEOLYSIS	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex	nucleotide-excision repair, DNA damage recognition|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity|damaged DNA binding|DNA-dependent ATPase activity	nucleotide-excision repair factor 4 complex|Cul3-RING ubiquitin ligase complex
YKL075C_p	YKL075C	YKL075C	hom	Uncharacterized	1.47404172718036	0.0702351783150736	no	382	0.0783021018159635	262	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; proposed to be involved in resistance to streptozotocin and camptothecin	response to drug	molecular_function	cytoplasm
YLR324W	YLR324W	PEX30	hom	Verified	1.47381300342005	0.0702659731050422	no	383	0.0980818320727402	376	NA	FF|FT	PEROXISOME ORGANIZATION			Peroxisomal integral membrane protein, involved in negative regulation of peroxisome number; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p	peroxisome organization	molecular_function	integral to membrane|peroxisome|integral to peroxisomal membrane
YOR196C	YOR196C	LIP5	hom	Verified	1.47226184859956	0.0704750907384388	no	384	0.0875239929740846	406	NA	FT	KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Protein involved in biosynthesis of the coenzyme lipoic acid, has similarity to E. coli lipoic acid synthase	protein lipoylation	lipoate synthase activity	mitochondrion
YHR082C	YHR082C	KSP1	hom	Verified	1.47088006074552	0.0706617779420324	no	385	0.0736623851860901	306	NA	FT	PROTEIN LOCALIZATION|SIGNALING|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Serine/threonine protein kinase; associates with TORC1 and likely involved in TOR signaling cascades; negative regulator of autophagy; nuclear translocation required for haploid filamentous growth; regulates filamentous growth induced nuclear translocation of Bcy1p, Fus3p, and Sks1p; overproduction causes allele-specific suppression of prp20-10; protein abundance increases in response to DNA replication stress	TOR signaling cascade|protein phosphorylation|Unknown|cellular protein localization|regulation of filamentous growth|negative regulation of macroautophagy	protein serine/threonine kinase activity|protein kinase activity	nucleus|cytoplasm
YIL036W	YIL036W	CST6	hom	Verified	1.4705933575118	0.0707005607047826	no	386	0.0513548741953954	295	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Basic leucine zipper (bZIP) transcription factor, in ATF/CREB family; mediates transcriptional activation of NCE103 (encoding carbonic anhydrase) in response to low CO2 levels such as in the ambient air; proposed to be a regulator of oleate responsive genes; involved in utilization of non-optimal carbon sources and chromosome stability; CST6 has a paralog, ACA1, that arose from the whole genome duplication	cellular response to carbon dioxide|positive regulation of transcription from RNA polymerase II promoter by oleic acid|cellular response to oleic acid|positive regulation of transcription from RNA polymerase II promoter|DNA metabolic process	sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YMR026C	YMR026C	PEX12	hom	Verified	1.47057394069071	0.0707031878376556	no	387	0.0885108519759259	295	NA	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION			C3HC4-type RING-finger peroxin and E3 ubiquitin ligase, required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder	protein import into peroxisome matrix	ubiquitin-protein ligase activity|protein binding	integral to peroxisomal membrane
YML074C	YML074C	FPR3	hom	Verified	1.4701780053185	0.0707567750101262	no	388	0.056331433435853	224	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION	NUCLEUS		Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p	meiotic recombination checkpoint	peptidyl-prolyl cis-trans isomerase activity|macrolide binding	nucleolus
YAL012W	YAL012W	CYS3	hom	Verified	1.46970563429451	0.0708207480501726	no	389	0.115467014144635	486	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM			Cystathionine gamma-lyase, catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine; protein abundance increases in response to DNA replication stress	sulfur amino acid metabolic process|cysteine biosynthetic process|cysteine biosynthetic process via cystathionine|transsulfuration|cysteine metabolic process	cystathionine gamma-lyase activity	cytoplasm
YEL013W	YEL013W	VAC8	hom	Verified	1.46779814835055	0.0710795303009276	no	390	0.059411093665	298	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Phosphorylated and palmitoylated vacuolar membrane protein that interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions	piecemeal microautophagy of nucleus|vacuole inheritance|CVT vesicle assembly|vacuole fusion, non-autophagic|macroautophagy|nucleus-vacuole junction assembly	protein anchor	fungal-type vacuole membrane|nucleus-vacuole junction|Myo2p-Vac17p-Vac8p transport complex
YCR043C_p	YCR043C	YCR043C	hom	Uncharacterized	1.46535362162614	0.071412231954958	no	391	0.0844636159733896	389	NA	FT		GOLGI APPARATUS|SITE OF POLARIZED GROWTH		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene	biological_process	molecular_function	Golgi apparatus|mating projection tip
YLL021W	YLL021W	SPA2	hom	Verified	1.46521719399773	0.0714308349963623	no	392	0.0829373440503226	340	NA	FT	CELL CYCLE|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH		Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate	regulation of initiation of mating projection growth|regulation of termination of mating projection growth|pseudohyphal growth|invasive filamentous growth|mating projection assembly	cytoskeletal regulatory protein binding	incipient cellular bud site|cellular bud neck|mating projection tip|cellular bud tip
YDL061C	YDL061C	RPS29B	hom	Verified	1.46396541665563	0.0716016989060394	no	393	0.0626074651458091	278	NA	FT	TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29B has a paralog, RPS29A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic small ribosomal subunit
YBR072C-A_p	YBR072C-A	YBR072C-A	hom	Uncharacterized	1.46147795590434	0.071942160418017	no	394	0.0668431810741007	276	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YML106W	YML106W	URA5	hom	Verified	1.46134794091426	0.0719599897919273	no	395	0.0678569585941222	291	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		Major orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA5 has a paralog, URA10, that arose from the whole genome duplication	'de novo' pyrimidine nucleobase biosynthetic process|pyrimidine ribonucleoside biosynthetic process	orotate phosphoribosyltransferase activity	nucleus|cytoplasm
YPL192C	YPL192C	PRM3	hom	Verified	1.45995595085188	0.0721510902420318	no	396	0.0552849972190351	264	NA	FT	MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON		Pheromone-regulated protein required for nuclear envelope fusion during karyogamy; localizes to the outer face of the nuclear membrane; interacts with Kar5p at the spindle pole body	karyogamy involved in conjugation with cellular fusion|nuclear membrane fusion involved in karyogamy	molecular_function	nuclear envelope|spindle pole body|extrinsic to nuclear outer membrane
YGR132C	YGR132C	PHB1	hom	Verified	1.45634858874344	0.0726481399925914	no	397	0.0564319042828614	251	NA	FT	MEMBRANE ORGANIZATION|PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation	mitochondrion inheritance|protein folding|negative regulation of proteolysis|replicative cell aging|mitochondrion morphogenesis|inner mitochondrial membrane organization	molecular_function	mitochondrion|mitochondrial inner membrane
YHR044C	YHR044C	DOG1	hom	Verified	1.45492287287606	0.0728453074096825	no	398	0.0543406066307706	258	NA	FT	CARBOHYDRATE METABOLISM			2-deoxyglucose-6-phosphate phosphatase; paralogous to DOG2; member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed, in vivo substrate has not yet been identified	glucose metabolic process	2-deoxyglucose-6-phosphatase activity	cellular_component
YER015W	YER015W	FAA2	hom	Verified	1.45219946331218	0.0732230759445489	no	399	0.0742058765587772	353	NA	FT	KETONE METABOLISM|LIPID METABOLISM	MITOCHONDRION		Medium chain fatty acyl-CoA synthetase, activates imported fatty acids; accepts a wide range of fatty acid chain lengths with a preference for medium chains, C9:0-C13:0; localized to the peroxisome	long-chain fatty acid metabolic process	long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity|medium-chain fatty acid-CoA ligase activity	mitochondrion|peroxisome
YHL021C	YHL021C	AIM17	hom	Verified	1.45043828442344	0.0734681687802269	no	400	0.0664259298521	289	NA	FT	OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss	biological_process	molecular_function	mitochondrion
YPL134C	YPL134C	ODC1	hom	Verified	1.44814556161951	0.0737881727996298	no	401	0.0653936133258721	331	NA	FT		MITOCHONDRION		Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation	mitochondrial transport	dicarboxylic acid transmembrane transporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YEL042W	YEL042W	GDA1	hom	Verified	1.44709907612141	0.0739345883789538	no	402	0.0682337347130826	284	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate	protein glycosylation	guanosine-diphosphatase activity|uridine-diphosphatase activity	Golgi apparatus
YGR241C	YGR241C	YAP1802	hom	Verified	1.44603290303634	0.074083986679541	no	403	0.0850723327425637	378	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON		Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1802 has a paralog, YAP1801, that arose from the whole genome duplication	endocytosis	clathrin binding	actin cortical patch
YCR092C	YCR092C	MSH3	hom	Verified	1.44423847277937	0.0743359531133688	no	404	0.0836025393383723	401	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Mismatch repair protein, forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability	mismatch repair|mitotic recombination|meiotic mismatch repair|removal of nonhomologous ends|DNA recombination	DNA insertion or deletion binding|mismatched DNA binding|double-strand/single-strand DNA junction binding|loop DNA binding|Y-form DNA binding	MutSbeta complex|nucleus|cytoplasm
YDR014W	YDR014W	RAD61	hom	Verified	1.44134743115447	0.0747432768261363	no	405	0.0943010286031419	363	NA	FT	CELL CYCLE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Subunit of a complex (Scc3p, Pds5p, Rad61p) that inhibits sister chromatid cohesion; inhibited by Eco1p-acetylated cohesin subunits Smc3p and Mcd1p; related to the human Wapl protein that controls the association of cohesin with chromatin	mitotic sister chromatid cohesion	molecular_function	nuclear cohesin complex
YGR044C	YGR044C	RME1	hom	Verified	1.44083040861208	0.0748163001808188	no	406	0.0261596916285628	161	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CELL DIVISION	NUCLEUS		Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-alpha2 regulator; mediates cell type control of sporulation; relocalizes from nucleus to cytoplasm upon DNA replication stress	negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription during meiosis|negative regulation of meiosis|positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription involved in G1/S phase of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity	nucleus
YDR445C_d	YDR445C	YDR445C	hom	Dubious	1.43297607897529	0.0759323367855129	no	407	0.0930870803639847	319	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YFL011W	YFL011W	HXT10	hom	Verified	1.4322472277854	0.0760365400020232	no	408	0.091816006280502	365	NA	FT		MITOCHONDRION|PLASMA MEMBRANE		Putative hexose transporter, expressed at low levels and expression is repressed by glucose	hexose transport|transmembrane transport	galactose transmembrane transporter activity|mannose transmembrane transporter activity|fructose transmembrane transporter activity|glucose transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YGR276C	YGR276C	RNH70	hom	Verified	1.42961652632198	0.0764135548443434	no	409	0.073849652285289	297	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		3'-5' exoribonuclease; required for maturation of 3' ends of 5S rRNA and tRNA-Arg3 from dicistronic transcripts	U5 snRNA 3'-end processing|generation of mature 3'-end of 5S rRNA generated by RNA polymerase III|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|tRNA 3'-trailer cleavage, exonucleolytic	3'-5'-exoribonuclease activity|3'-5' exonuclease activity	nucleus
YNL079C	YNL079C	TPM1	hom	Verified	1.42491563094929	0.077090795353101	no	410	0.0850823479948569	413	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|CELL DIVISION|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|RNA LOCALIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently; TPM1 has a paralog, TPM2, that arose from the whole genome duplication	vacuole inheritance|exocytosis|intracellular mRNA localization|filamentous growth|budding cell apical bud growth|mitochondrion inheritance|budding cell isotropic bud growth|actin polymerization or depolymerization|actin filament organization|pseudohyphal growth|vesicle-mediated transport|establishment of cell polarity|actin filament bundle assembly	actin lateral binding	cellular bud neck contractile ring|actin filament bundle
YJR120W	YJR120W	YJR120W	hom	Verified	1.41629190404092	0.0783450286118687	no	411	0.0763775778341709	303	NA	FT	OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY			Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p	cellular respiration|sterol transport|mitochondrion organization	molecular_function	cellular_component
YDR433W_d	YDR433W	YDR433W	hom	Dubious	1.41384429033538	0.0787038130252698	no	412	0.0950222646961229	437	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR407W_p	YLR407W	YLR407W	hom	Uncharacterized	1.40959815584045	0.0793291859330896	no	413	0.0805682969506566	286	NA					Putative protein of unknown function; null mutant displays elongated buds and a large fraction of budded cells have only one nucleus	biological_process	molecular_function	cellular_component
YLR224W_p	YLR224W	YLR224W	hom	Uncharacterized	1.40856824189703	0.0794814375166119	no	414	0.0601491930790986	255	NA	FT	PROTEOLYSIS			F-box protein and component of SCF ubiquitin ligase complexes involved in ubiquitin-dependent protein catabolism; readily monoubiquitinated in vitro by SCF-Ubc4 complexes; YLR224W is not an essential gene	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular response to methylmercury	ubiquitin-protein ligase activity|protein binding, bridging	SCF ubiquitin ligase complex
YMR225C	YMR225C	MRPL44	hom	Verified	1.40815025077687	0.0795432919502037	no	415	0.0755480939798693	341	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YMR244C-A	YMR244C-A	COA6	hom	Verified	1.40515259635798	0.0799879533623512	no	416	0.0652571618393989	273	NA	FT		NUCLEUS|MITOCHONDRION		Protein involved in cytochrome c oxidase assembly; also required for efficient formation of respiratory supercomplexes comprised of Complexes III and IV; localizes to the mitochondrial intermembrane space; has a human homolog; transcription is induced in response to the DNA-damaging agent MMS; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YKL057C	YKL057C	NUP120	hom	Verified	1.40250869069969	0.0803816985745527	no	417	0.116323663606933	462	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP160	double-strand break repair|protein export from nucleus|ribosomal large subunit export from nucleus|maintenance of chromatin silencing at telomere|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|telomere tethering at nuclear periphery|nuclear pore distribution|mRNA export from nucleus in response to heat stress|mRNA export from nucleus|positive regulation of transcription, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter	structural constituent of nuclear pore	integral to membrane|nuclear pore|nuclear pore outer ring
YEL045C_d	YEL045C	YEL045C	hom	Dubious	1.39970559706095	0.0808007485244618	no	418	0.114191758990406	424	NA					Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; deletion gives MMS sensitivity, growth defect under alkaline conditions, less than optimal growth upon citric acid stress	Unknown	Unknown	Unknown
YKL221W	YKL221W	MCH2	hom	Verified	1.39949670450364	0.0808320429448033	no	419	0.0925471176808463	289	NA					Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport	transport	monocarboxylic acid transmembrane transporter activity|transporter activity	integral to membrane|membrane
YLR295C	YLR295C	ATP14	hom	Verified	1.39781965849719	0.0810836147407458	no	420	0.10721324382134	393	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; protein abundance increases in response to DNA replication stress	cristae formation|mitochondrial proton-transporting ATP synthase complex assembly|ATP synthesis coupled proton transport	hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism	mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
YPR051W	YPR051W	MAK3	hom	Verified	1.3916937771498	0.0820075737537986	no	421	0.116662371516664	490	NA	FT		NUCLEUS		Catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus	N-terminal protein amino acid acetylation	peptide alpha-N-acetyltransferase activity	NatC complex
YKL131W_d	YKL131W	YKL131W	hom	Dubious	1.39053431391679	0.0821833434901381	no	422	0.0501990408226712	199	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YAR023C_p	YAR023C	YAR023C	hom	Uncharacterized	1.39053157289851	0.0821837593528967	no	423	0.0806757225657278	344	NA					Putative integral membrane protein, member of DUP240 gene family	biological_process	molecular_function	cellular_component
YNL333W	YNL333W	SNZ2	hom	Verified	1.39041001537028	0.0822022034538308	no	424	0.082169578470038	315	NA	FT	COFACTOR METABOLISM			Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO2; interacts with Thi11p	pyridoxine metabolic process|thiamine biosynthetic process	protein binding	cellular_component
YHR094C	YHR094C	HXT1	hom	Verified	1.38830529322321	0.0825220505424403	no	425	0.0806438558096669	339	NA	FT		PLASMA MEMBRANE		Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting; HXT1 has a paralog, HXT6, what arose from the whole genome duplication	mannose transport|glucose transport	galactose transmembrane transporter activity|pentose transmembrane transporter activity|mannose transmembrane transporter activity|glucose transmembrane transporter activity|fructose transmembrane transporter activity	integral to membrane|plasma membrane
YML009W-B_d	YML009W-B	YML009W-B	hom	Dubious	1.38531928078863	0.0829774303408223	no	426	0.0857054359362288	376	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition	Unknown	Unknown	Unknown
YGL019W	YGL019W	CKB1	hom	Verified	1.37577438619045	0.0844457468907407	no	427	0.12254654719401	457	NA	FF|FT	RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION	NUCLEUS		Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases	regulation of transcription from RNA polymerase I promoter|protein phosphorylation|regulation of transcription from RNA polymerase III promoter|response to DNA damage stimulus	protein kinase regulator activity|protein serine/threonine kinase inhibitor activity	protein kinase CK2 complex|UTP-C complex
YJL065C	YJL065C	DLS1	hom	Verified	1.37519466359585	0.0845355511445602	no	428	0.11143910991077	387	NA	FT	GENE SILENCING	NUCLEUS		Subunit of ISW2/yCHRAC chromatin accessibility complex; ISW2/yCHRAC also includes Itc1p, Isw2p, and Dpb4p; involved in inheritance of telomeric silencing; DLS1 has a paralog, DPB3, that arose from the whole genome duplication	chromatin silencing at telomere	molecular_function	chromatin accessibility complex|nucleus
YNL043C_d	YNL043C	YNL043C	hom	Dubious	1.37385347780219	0.0847435874781698	no	429	0.0879642514062192	345	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W	Unknown	Unknown	Unknown
YPR015C_p	YPR015C	YPR015C	hom	Uncharacterized	1.37188944163334	0.0850489288770502	no	430	0.0933939884357794	315	NA					Putative protein of unknown function; overexpression causes a cell cycle delay or arrest	biological_process	sequence-specific DNA binding	cellular_component
YML083C	YML083C	YML083C	hom	Verified	1.37183613160728	0.0850572282680116	no	431	0.0621484812828215	216	NA					Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions	biological_process	molecular_function	cellular_component
YHR136C	YHR136C	SPL2	hom	Verified	1.37021153100221	0.0853104399112574	no	432	0.0927141973647815	368	NA					Protein with similarity to cyclin-dependent kinase inhibitors; downregulates low-affinity phosphate transport during phosphate limitation; overproduction suppresses a plc1 null mutation; GFP-fusion protein localizes to the cytoplasm	response to temperature stimulus	enzyme inhibitor activity	cytoplasm
YEL072W	YEL072W	RMD6	hom	Verified	1.3684892074697	0.0855794989706807	no	433	0.0866138717737533	345	NA	FT	CELL CYCLE			Protein required for sporulation	biological_process	molecular_function	cellular_component
YJR099W	YJR099W	YUH1	hom	Verified	1.36306340859053	0.0864312638222034	no	434	0.0685096179461255	250	NA	FT	PROTEOLYSIS			Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p	protein deubiquitination	ubiquitin-specific protease activity	cytoplasm
YOR065W	YOR065W	CYT1	hom	Verified	1.35956813150278	0.086983314318516	no	435	0.072136142964979	274	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex	oxidative phosphorylation|mitochondrial electron transport, ubiquinol to cytochrome c	electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity	mitochondrion|mitochondrial respiratory chain|integral to membrane|mitochondrial inner membrane|mitochondrial respiratory chain complex III
YKL048C	YKL048C	ELM1	hom	Verified	1.3586325212396	0.0871315322429881	no	436	0.0882211441439709	379	NA	FT	CELL CYCLE|CELL DIVISION|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases, such as Kin4p; forms part of the bud neck ring	positive regulation of protein autophosphorylation|protein autophosphorylation|cell morphogenesis|budding cell bud growth|protein phosphorylation|response to drug|septin checkpoint|pseudohyphal growth|glucose metabolic process|axial cellular bud site selection|response to osmotic stress|cytokinesis	protein serine/threonine kinase activity|protein kinase activity	cellular bud neck contractile ring
YLR388W	YLR388W	RPS29A	hom	Verified	1.35444224212971	0.0877976642579509	no	437	0.131670025923647	489	NA	FT	TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29A has a paralog, RPS29B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic small ribosomal subunit
YMR306C-A_d	YMR306C-A	YMR306C-A	hom	Dubious	1.35281815852413	0.0880568650964219	no	438	0.0730437835988952	325	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR207C	YMR207C	HFA1	hom	Verified	1.3498001541285	0.088540047707083	no	439	0.0792866168776831	340	NA	FT	KETONE METABOLISM|LIPID METABOLISM	MITOCHONDRION		Mitochondrial acetyl-coenzyme A carboxylase; catalyzes the production of malonyl-CoA in mitochondrial fatty acid biosynthesis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress	fatty acid biosynthetic process	acetyl-CoA carboxylase activity	mitochondrion
YNL237W	YNL237W	YTP1	hom	Verified	1.34831039979947	0.0887792842969294	no	440	0.150992651797491	569	NA	FF|FT		MITOCHONDRION		Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins	biological_process	molecular_function	integral to membrane|membrane
YBR251W	YBR251W	MRPS5	hom	Verified	1.34700959110059	0.0889885718626432	no	441	0.133622028735042	493	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YGL176C_p	YGL176C	YGL176C	hom	Uncharacterized	1.34585655201316	0.0891743915766389	no	442	0.0983615419721732	370	NA					Putative protein of unknown function; deletion mutant is viable and has no detectable phenotype	biological_process	molecular_function	cellular_component
YBR170C	YBR170C	NPL4	hom	Verified	1.34510724039222	0.089295302688819	no	443	0.0914147044494791	331	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	UBIQUITIN LIGASE COMPLEX	Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; assists Cdc48p in the dislocation of misfolded, polyubiquitinated ERAD substrates that are subsequently delivered to the proteasome for degradation; also involved in the regulated destruction of resident ER membrane proteins, such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing (RUP)	retrograde protein transport, ER to cytosol|proteasomal ubiquitin-dependent protein catabolic process|mitochondria-associated protein catabolic process|mitotic spindle disassembly|ER-associated protein catabolic process|ER-associated misfolded protein catabolic process|Unknown|cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process	molecular_function	Doa10p ubiquitin ligase complex|integral to membrane|Cdc48p-Npl4p-Ufd1p AAA ATPase complex|Cdc48p-Npl4p-Vms1p AAA ATPase complex|nuclear outer membrane-endoplasmic reticulum membrane network
YGR225W	YGR225W	AMA1	hom	Verified	1.34433638832919	0.0894198168664795	no	444	0.0833435999628187	339	NA	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Activator of meiotic anaphase promoting complex (APC/C); Cdc20p family member; required for initiation of spore wall assembly; required for Clb1p degradation during meiosis	ascospore wall assembly|positive regulation of protein catabolic process|ascospore formation|meiosis I	enzyme activator activity	anaphase-promoting complex
YMR114C	YMR114C	YMR114C	hom	Verified	1.3414909425673	0.089880554242889	no	445	0.0822909764418271	301	NA	FT		NUCLEUS		Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR114C is not an essential gene	biological_process	molecular_function	ribosome|nucleus|cytoplasm
YOR187W	YOR187W	TUF1	hom	Verified	1.34064442217431	0.0900179636054712	no	446	0.165055759699904	501	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial translation elongation factor Tu; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans	mitochondrial translational elongation|mitochondrial translation	GTPase activity|translation elongation factor activity	mitochondrion|mitochondrial matrix
YER179W	YER179W	DMC1	hom	Verified	1.34029820689642	0.09007420711061	no	447	0.0734988151457179	336	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Meiosis-specific protein required for repair of double-strand breaks and pairing between homologous chromosomes; homolog of Rad51p and the bacterial RecA protein; binds ssDNA and dsDNA, forms helical filaments; stimulated by Rdh54p	meiosis|reciprocal meiotic recombination|meiotic joint molecule formation	double-stranded DNA binding|single-stranded DNA binding	condensed nuclear chromosome|nucleus
YBL006C	YBL006C	LDB7	hom	Verified	1.33765118397112	0.0905050855227115	no	448	0.168932376470961	655	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|CELL WALL ORG/BIOGENESIS	NUCLEUS	RSC COMPLEX	Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions	ATP-dependent chromatin remodeling|cell wall mannoprotein biosynthetic process|nucleosome disassembly|transcription elongation from RNA polymerase II promoter	DNA translocase activity	RSC complex
YFL049W	YFL049W	SWP82	hom	Verified	1.3364274889975	0.0907047931932012	no	449	0.078025695147513	314	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS	RSC COMPLEX	Member of the SWI/SNF chromatin remodeling complex; has an as yet unidentified role in the complex; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p; relocates to the cytosol under hypoxic conditions	positive regulation of transcription from RNA polymerase II promoter	molecular_function	SWI/SNF complex|nucleus
YBR173C	YBR173C	UMP1	hom	Verified	1.33308431592996	0.0912520678692593	no	450	0.0782336713308966	316	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE|PROTEOLYSIS	NUCLEUS		Short-lived chaperone required for correct maturation of the 20S proteasome; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its assembly	proteasome assembly|response to DNA damage stimulus|ubiquitin-dependent protein catabolic process	molecular_function	nucleus|cytoplasm
YPR119W	YPR119W	CLB2	hom	Verified	1.32736920238429	0.0921932911038553	no	451	0.108508051148911	481	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON		B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome	G2/M transition of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|positive regulation of spindle pole body separation	cyclin-dependent protein kinase regulator activity	nucleus|spindle pole body|cellular bud neck|spindle|cytoplasm
YOR001W	YOR001W	RRP6	hom	Verified	1.32664486988895	0.0923130928404218	no	452	0.0501930963275533	246	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|RNA LOCALIZATION	NUCLEUS		Nuclear exosome exonuclease component; has 3'-5' exonuclease activity; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10); mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay	nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent snRNA catabolic process|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|histone mRNA catabolic process|nuclear polyadenylation-dependent antisense transcript catabolic process|U1 snRNA 3'-end processing|polyadenylation-dependent snoRNA 3'-end processing|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|U5 snRNA 3'-end processing|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear retention of pre-mRNA at the site of transcription|nuclear polyadenylation-dependent mRNA catabolic process|U4 snRNA 3'-end processing|nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription	3'-5'-exoribonuclease activity	nucleolus|nucleus|nuclear exosome (RNase complex)
YBL090W	YBL090W	MRP21	hom	Verified	1.32554068997645	0.0924959414705183	no	453	0.119818986953897	440	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit; MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences	mitochondrial translational initiation|mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YMR142C	YMR142C	RPL13B	hom	Verified	1.32507058671956	0.0925738703276427	no	454	0.104578514885216	413	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L13B; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13B has a paralog, RPL13A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YNL046W_p	YNL046W	YNL046W	hom	Uncharacterized	1.32358619085633	0.0928202569253309	no	455	0.078158731193513	278	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative protein of unknown function; expression depends on Swi5p; GFP-fusion protein localizes to the endoplasmic reticulum; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)	biological_process	molecular_function	endoplasmic reticulum
YGR100W	YGR100W	MDR1	hom	Verified	1.31319590259636	0.0945584721603985	no	456	0.104295210434478	352	NA	FT	PROTEIN LOCALIZATION|SIGNALING|NUCLEOTIDE METABOLISM			Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function	intracellular protein transport	Rab GTPase activator activity	cytoplasm
YDR203W_d	YDR203W	YDR203W	hom	Dubious	1.31227235828212	0.0947141275974386	no	457	0.134335954753133	548	NA	FF				Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YER049W	YER049W	TPA1	hom	Verified	1.31180859613062	0.0947923618984023	no	458	0.072240916698086	284	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|OXIDATION-REDUCTION PROCESS	NUCLEUS		Poly(rA)-binding protein involved in translation termination efficiency, mRNA poly(A) tail length and mRNA stability; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; similar to prolyl 4-hydroxylases; binds Fe(III) and 2-oxoglutarate	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|translational termination	poly(A) RNA binding	nucleus
YOR234C	YOR234C	RPL33B	hom	Verified	1.31177195866063	0.0947985444810471	no	459	0.103051265848691	331	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L33B; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33B has a paralog, RPL33A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YGR200C	YGR200C	ELP2	hom	Verified	1.31031424290542	0.0950447755654936	no	460	0.115770713128767	432	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin	regulation of transcription from RNA polymerase II promoter|protein urmylation|tRNA wobble uridine modification	molecular_function	Elongator holoenzyme complex|nucleus|cytoplasm
YGL125W	YGL125W	MET13	hom	Verified	1.30987685288874	0.0951187494104309	no	461	0.103247869173514	320	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Major isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway	methionine biosynthetic process	methylenetetrahydrofolate reductase (NADPH) activity	mitochondrion
YLR144C	YLR144C	ACF2	hom	Verified	1.30967693665501	0.0951525744775521	no	462	0.0918714385975763	325	NA	FT	CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION			Intracellular beta-1,3-endoglucanase; expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly; protein abundance increases in response to DNA replication stress	actin cytoskeleton organization	glucan endo-1,3-beta-D-glucosidase activity	intracellular
YMR037C	YMR037C	MSN2	hom	Verified	1.30302477189363	0.0962831522691299	no	463	0.0952884436934826	355	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Transcriptional activator; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression; MSN2 has a paralog, MSN4, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription from RNA polymerase II promoter in response to a hypotonic environment|positive regulation of transcription from RNA polymerase II promoter in response to alkalinity|positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation|positive regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation|positive regulation of transcription from RNA polymerase II promoter in response to acidity|chromatin remodeling|positive regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide|regulation of replicative cell aging by regulation of transcription from RNA polymerase II promoter in response to caloric restriction|positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance|positive regulation of transcription from RNA polymerase II promoter in response to increased salt|positive regulation of transcription from RNA polymerase II promoter in response to freezing|positive regulation of transcription from RNA polymerase II promoter in response to ethanol|age-dependent response to oxidative stress involved in chronological cell aging|replicative cell aging|positive regulation of transcription from RNA polymerase II promoter in response to hydrostatic pressure|cellular response to methylmercury|positive regulation of transcription from RNA polymerase II promoter in response to nitrosative stress|positive regulation of transcription from RNA polymerase II promoter in response to cold|positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding	cytosol|nucleus
YCR090C_p	YCR090C	YCR090C	hom	Uncharacterized	1.2989321317486	0.0969836107106162	no	464	0.0647707399605237	320	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YCR090C is not an essential gene	biological_process	molecular_function	nucleus|cytoplasm
YLL062C	YLL062C	MHT1	hom	Verified	1.29882513677703	0.0970019730253594	no	465	0.0915516270711805	275	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio	sulfur amino acid metabolic process	homocysteine S-methyltransferase activity	cytoplasm
YBR223C	YBR223C	TDP1	hom	Verified	1.2968114012056	0.0973480434252312	no	466	0.106794079076558	399	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Tyrosyl-DNA phosphodiesterase I; hydrolyzes 3' and 5'-phosphotyrosyl bonds; involved in the repair of DNA lesions created by topoisomerase I and topoisomerase II; mutations in human homolog result in the neurodegenerative disease SCANI	DNA repair	3'-tyrosyl-DNA phosphodiesterase activity|5'-tyrosyl-DNA phosphodiesterase activity	nucleus
YDR143C	YDR143C	SAN1	hom	Verified	1.2965313608319	0.097396241395926	no	467	0.0942983600190933	304	NA	FT	PROTEOLYSIS	NUCLEUS		Ubiquitin-protein ligase; involved in the proteasome-dependent degradation of aberrant nuclear proteins; targets substrates with regions of exposed hydrophobicity containing 5 or more contiguous hydrophobic residues; contains intrinsically disordered regions that contribute to substrate recognition	nucleus-associated proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to misfolded protein|response to stress	ubiquitin-protein ligase activity	nucleus|cytoplasm
YLR240W	YLR240W	VPS34	hom	Verified	1.29503119537297	0.097654734148499	no	468	0.105156593034159	444	NA	FT	PROTEIN LOCALIZATION|LIPID METABOLISM|SIGNALING|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION	GOLGI APPARATUS		Phosphatidylinositol (PI) 3-kinase that synthesizes PI-3-phosphate; forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting; activated by the GTP-bound form of Gpa1p; a fraction is localized, with Vps15p, to nuclear pores at nucleus-vacuole junctions and may facilitate transcription elongation for genes positioned at the nuclear periphery	peroxisome degradation|phosphatidylinositol phosphorylation|protein phosphorylation	1-phosphatidylinositol-3-kinase activity|protein kinase activity	endosome|fungal-type vacuole membrane|phosphatidylinositol 3-kinase complex I|phosphatidylinositol 3-kinase complex II|peroxisome|pre-autophagosomal structure
YBR035C	YBR035C	PDX3	hom	Verified	1.29225863878555	0.0981337952865154	no	469	0.0898976334060763	412	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM			Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism	fatty acid metabolic process	pyridoxamine-phosphate oxidase activity	cellular_component
YIL146C	YIL146C	ATG32	hom	Verified	1.28960720564242	0.0985935363100951	no	470	0.0807213723879849	320	NA	FT	CELL WALL ORG/BIOGENESIS	MITOCHONDRION		Mitochondrial outer membrane protein required to initiate mitophagy; recruits the autophagy adaptor protein Atg11p and the ubiquitin-like protein Atg8p to the mitochondrial surface to initiate mitophagy, the selective vacuolar degradation of mitochondria in response to starvation; can promote pexophagy when placed ectopically in the peroxisomal membrane	fungal-type cell wall organization|mitochondrion degradation	molecular_function	integral to mitochondrial outer membrane
YGR007W	YGR007W	ECT1	hom	Verified	1.28794643724073	0.0988823045307979	no	471	0.104823262233048	362	NA	FT	LIPID METABOLISM	NUCLEUS		Ethanolamine-phosphate cytidylyltransferase, catalyzes the second step of phosphatidylethanolamine biosynthesis; involved in the maintenance of plasma membrane; similar to mammalian CTP: phosphocholine cytidylyl-transferases	phosphatidylethanolamine biosynthetic process	ethanolamine-phosphate cytidylyltransferase activity	nucleus|cytoplasm
YNL204C	YNL204C	SPS18	hom	Verified	1.28509927044964	0.0993787982492599	no	472	0.111399392885212	422	NA	FT	SIGNALING|NUCLEOTIDE METABOLISM			Protein of unknown function, contains a putative zinc-binding domain; expressed during sporulation	sporulation resulting in formation of a cellular spore	molecular_function	cellular_component
YMR319C	YMR319C	FET4	hom	Verified	1.28336568051128	0.0996819958282457	no	473	0.16655630193704	623	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Low-affinity Fe(II) transporter of the plasma membrane	intracellular copper ion transport|zinc ion transport|low-affinity iron ion transport|copper ion import	copper ion transmembrane transporter activity|iron ion transmembrane transporter activity	integral to membrane|plasma membrane|integral to plasma membrane
YPR126C_d	YPR126C	YPR126C	hom	Dubious	1.28164195015845	0.0999841385697112	no	474	0.101732325442733	352	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YJL007C_d	YJL007C	YJL007C	hom	Dubious	1.28102457259903	0.100092517616837	no	475	0.0944964656356008	350	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGR037C	YGR037C	ACB1	hom	Verified	1.27934132696341	0.100388442747198	no	476	0.184930221143069	685	NA	FF|FT	KETONE METABOLISM|LIPID METABOLISM	NUCLEUS		Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion; protein abundance increases in response to DNA replication stress	long-chain fatty acid transport|chronological cell aging|fatty acid metabolic process	long-chain fatty acid transporter activity|fatty-acyl-CoA binding	extracellular region|nucleus|cytoplasm
YGL003C	YGL003C	CDH1	hom	Verified	1.27834790393006	0.100563392062736	no	477	0.109319496968837	453	NA	FT	CELL CYCLE|CELL DIVISION|PROTEOLYSIS|CYTOSKELETON ORGANIZATION	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including Cdc20p, Ase1p, Cin8p and Fin1p	activation of mitotic anaphase-promoting complex activity|negative regulation of spindle pole body separation|positive regulation of mitotic metaphase/anaphase transition|Unknown|regulation of cell size	anaphase-promoting complex binding|cyclin binding|ubiquitin-protein ligase activator activity	nucleus|anaphase-promoting complex|cytoplasm
YGL015C_p	YGL015C	YGL015C	hom	Uncharacterized	1.27771360722467	0.100675212797424	no	478	0.0836420298245174	296	NA					Putative protein of unknown function; null mutants accumulate cargo in the Golgi	biological_process	molecular_function	cellular_component
YKL184W	YKL184W	SPE1	hom	Verified	1.27460935992733	0.101223771447304	no	479	0.0997257910502717	322	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM			Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation	pantothenate biosynthetic process|putrescine biosynthetic process	ornithine decarboxylase activity	cytoplasm
YNL322C	YNL322C	KRE1	hom	Verified	1.27113823701566	0.101839737190936	no	480	0.111708300355054	470	NA	FT	CELL WALL ORG/BIOGENESIS	PLASMA MEMBRANE		Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor	fungal-type cell wall organization	structural constituent of cell wall	fungal-type cell wall|integral to membrane
YFR009W	YFR009W	GCN20	hom	Verified	1.27084001911256	0.101892784239312	no	481	0.150531281239921	582	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|NUCLEOTIDE METABOLISM		RIBOSOME	Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA	regulation of translational elongation	ATPase activity	cytosol|cytosolic ribosome
YOR133W	YOR133W	EFT1	hom	Verified	1.26785960685802	0.10242404561313	no	482	0.108611976845226	432	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM		RIBOSOME	Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication	translational elongation	translation elongation factor activity	ribosome
YBR272C	YBR272C	HSM3	hom	Verified	1.26778704947428	0.102437004103753	no	483	0.0899555299164098	321	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE	NUCLEUS		Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); involved in DNA mismatch repair during slow growth; weak similarity to Msh1p; related to human 19S subunit S5b; structural study suggests Hsm3p is a scaffold protein for Rpt1p-Rpt2p complex formation	mismatch repair|proteasome regulatory particle assembly	molecular_function	cytosol|proteasome regulatory particle, base subcomplex|nucleus|cytoplasm
YOR200W_d	YOR200W	YOR200W	hom	Dubious	1.26369662321806	0.103169468805612	no	484	0.153979821121291	571	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRM1/YOR201c	Unknown	Unknown	Unknown
YHR146W	YHR146W	CRP1	hom	Verified	1.26311238401291	0.103274397026126	no	485	0.120318637845037	463	NA	FT		NUCLEUS		Protein that binds to cruciform DNA structures	biological_process	DNA binding	nucleus
YNL087W	YNL087W	TCB2	hom	Verified	1.26268653733653	0.10335092706389	no	486	0.1075513132515	407	NA	FT		ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains 3 calcium and lipid binding domains; mRNA is targeted to the bud	biological_process	lipid binding	cellular bud|cortical endoplasmic reticulum
YDR184C	YDR184C	ATC1	hom	Verified	1.26260586566331	0.103365429421821	no	487	0.126416243951841	501	NA	FT	CELL CYCLE|CELL DIVISION	NUCLEUS		Nuclear protein; possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding pattern; relative distribution to the nucleus decreases upon DNA replication stress	bipolar cellular bud site selection|response to stress	molecular_function	nucleus
YLR210W	YLR210W	CLB4	hom	Verified	1.26109119510621	0.103637996272288	no	488	0.103057871817833	343	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	NUCLEUS|CYTOSKELETON		B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation	G2/M transition of mitotic cell cycle|S phase of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|positive regulation of spindle pole body separation	cyclin-dependent protein kinase regulator activity	nucleus|spindle pole body|cytoplasm
YJL105W	YJL105W	SET4	hom	Verified	1.25852160717405	0.104101588975296	no	489	0.110528338351845	451	NA	FT	CHROMATIN ORGANIZATION			Protein of unknown function, contains a SET domain; SET4 has a paralog, SET3, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YIL133C	YIL133C	RPL16A	hom	Verified	1.25594379781331	0.104568173795233	no	490	0.110312283911505	436	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L16A; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16A has a paralog, RPL16B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YBR072W	YBR072W	HSP26	hom	Verified	1.25506811198232	0.104727017585795	no	491	0.0952335409636142	386	NA	FT		NUCLEUS		Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires heat-induced conformational change; also has mRNA binding activity	protein folding|response to stress	unfolded protein binding|mRNA binding	nucleus|cytoplasm
YGL236C	YGL236C	MTO1	hom	Verified	1.25405524939989	0.104910962222889	no	492	0.121325023077039	435	NA	FT	RNA PROCESSING|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants	mitochondrial tRNA wobble uridine modification	molecular_function	mitochondrion
YDR073W	YDR073W	SNF11	hom	Verified	1.25066659150306	0.105528072057836	no	493	0.0871229840281173	340	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RSC COMPLEX	Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p; relocates to the cytosol under hypoxic conditions	positive regulation of transcription from RNA polymerase II promoter	molecular_function	SWI/SNF complex
YHR202W_p	YHR202W	YHR202W	hom	Uncharacterized	1.25056753186111	0.105546151257041	no	494	0.106045519965866	434	NA	FT	NUCLEOTIDE METABOLISM			Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization	biological_process	molecular_function	cytosol|fungal-type vacuole
YOL024W_p	YOL024W	YOL024W	hom	Uncharacterized	1.25008792382646	0.105633715342849	no	495	0.0941685908210065	337	NA					Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site; YOL024W has a paralog, IGD1, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YBR200W	YBR200W	BEM1	hom	Verified	1.24987110476	0.105673318161169	no	496	0.0868868554721325	345	NA	FT		SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein containing SH3-domains, involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p	establishment of cell polarity|cell morphogenesis involved in conjugation with cellular fusion	protein complex scaffold|phosphatidylinositol-3-phosphate binding	incipient cellular bud site|mating projection tip|cellular bud neck|cellular bud tip
YHR151C	YHR151C	MTC6	hom	Verified	1.24824375261755	0.105970902839933	no	497	0.104346830396568	444	NA					Protein of unknown function; mtc6 is synthetically sick with cdc13-1	biological_process	molecular_function	cellular_component
YCR105W	YCR105W	ADH7	hom	Verified	1.24772756895651	0.106065420812529	no	498	0.129461748172934	427	NA	FT	OXIDATION-REDUCTION PROCESS			NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance	alcohol metabolic process	alcohol dehydrogenase (NADP+) activity	cellular_component
YDR466W	YDR466W	PKH3	hom	Verified	1.2476043651003	0.106087989572223	no	499	0.165099747475078	567	NA	FF|FT	SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION			Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant	MAPK cascade involved in cell wall biogenesis|protein phosphorylation	protein kinase activity	cellular_component
YLR279W_d	YLR279W	YLR279W	hom	Dubious	1.24589824412481	0.106400877404684	no	500	0.126575124777157	475	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR288C	YLR288C	MEC3	hom	Verified	1.24536050096182	0.106499632821937	no	501	0.0844395994750126	315	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS|CHROMOSOME		DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1	telomere maintenance via recombination|DNA damage checkpoint|DNA metabolic process|chromatin silencing at telomere	DNA binding	nucleus|checkpoint clamp complex
YFR046C	YFR046C	CNN1	hom	Verified	1.24416091624064	0.106720172494384	no	502	0.0896170224787602	367	NA	FT	CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME	KINETOCHORE	Kinetochore protein; associated with the essential kinetochore proteins Nnf1p and Spc24p; phosphorylated by Clb5-Cdk1, Mps1p, Ipl1p and to a lesser extent by Clb2-Cdk1; localizes to the lower region of the Ndc80 complex during anaphase and regulates KMN activity by inhibiting the Mtw1 and Spc105 complexes from binding to the Ndc80 complex; similar to metazoan CENP-T	chromosome segregation	molecular_function	nucleus|kinetochore
YFL013C	YFL013C	IES1	hom	Verified	1.24276861895647	0.106976554766486	no	503	0.134683390437834	468	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Subunit of the INO80 chromatin remodeling complex	nucleosome mobilization	molecular_function	nucleus|Ino80 complex
YMR119W-A_d	YMR119W-A	YMR119W-A	hom	Dubious	1.24196427128941	0.107124872361508	no	504	0.106627300477885	371	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YAR002C-A	YAR002C-A	ERP1	hom	Verified	1.24091364600403	0.107318825567443	no	505	0.0866463006909572	360	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		Member of the p24 family involved in ER to Golgi transport; forms heterotrimeric complex with Erp2p, Emp24p, and Erv25p; localized to COPII-coated vesicles; ERP1 has a paralog, ERP6, that arose from the whole genome duplication	ER to Golgi vesicle-mediated transport	molecular_function	mitochondrion|ER to Golgi transport vesicle
YPL236C	YPL236C	ENV7	hom	Verified	1.23996690128719	0.107493818386153	no	506	0.0847116904759988	385	NA	FT	PROTEIN PHOSPHORYLATION|VACUOLAR PROTEIN PROCESSING			Vacuolar membrane protein kinase; negatively regulates membrane fusion; associates with vacuolar membrane through palmitoylation of one or more cysteines in consensus sequence; vacuolar membrane association is essential to its kinase activity; mutant shows defect in CPY processing; ortholog of human serine/threonine kinase 16 (STK16)	vacuolar protein processing	protein serine/threonine kinase activity	fungal-type vacuole membrane
YBR178W_d	YBR178W	YBR178W	hom	Dubious	1.23668931851597	0.108101222861961	no	507	0.115333339415704	425	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR177C	Unknown	Unknown	Unknown
YMR138W	YMR138W	CIN4	hom	Verified	1.23591856077184	0.108244418512183	no	508	0.11933101067653	446	NA	FT	SIGNALING			GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; regulated by the GTPase-activating protein, Cin2p, the human retinitis pigmentosa 2 (RP2) homolog	protein folding|tubulin complex assembly|tubulin complex biogenesis	GTP binding	cytoplasm
YBR228W	YBR228W	SLX1	hom	Verified	1.23335362491175	0.108721929524037	no	509	0.119730445928113	448	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Subunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p	DNA-dependent DNA replication	5'-flap endonuclease activity	Slx1-Slx4 complex|nucleus
YHR135C	YHR135C	YCK1	hom	Verified	1.23327424697384	0.108736731346377	no	510	0.10382882914015	390	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL DIVISION|PROTEIN PHOSPHORYLATION	ENDOPLASMIC RETICULUM|MITOCHONDRION|PLASMA MEMBRANE		Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; YCK1 has a paralog, YCK2, that arose from the whole genome duplication	cell morphogenesis|endocytosis|protein phosphorylation|cytokinesis|response to glucose stimulus	protein serine/threonine kinase activity|protein kinase activity	mitochondrion|endoplasmic reticulum|plasma membrane
YLR205C	YLR205C	HMX1	hom	Verified	1.23272659866798	0.108838892321349	no	511	0.0805966664255625	318	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants	response to oxidative stress|cellular iron ion homeostasis|heme catabolic process	heme oxygenase (decyclizing) activity	endoplasmic reticulum|membrane|nuclear outer membrane
YFL023W	YFL023W	BUD27	hom	Verified	1.23239429031479	0.108900916367875	no	512	0.111727882498769	501	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION		RIBOSOME	Unconventional prefoldin protein involved in translation initiation; mutants have inappropriate expression of nutrient sensitive genes due to translational derepression of Gcn4p transcription factor; diploid mutants show random budding; ortholog of human URI/RMP	formation of translation preinitiation complex	molecular_function	cytosolic ribosome|cytoplasm
YJL055W_p	YJL055W	YJL055W	hom	Uncharacterized	1.23234919356565	0.108909335456427	no	513	0.111114237572337	426	NA	FT		NUCLEUS		Putative protein of unknown function, proposed to be involved in the metabolism of purine and pyrimidine base analogues; deletion mutants are sensitive to HAP and AHA; overexpression confers resistance to 5-FOA and 5-FU	response to chemical stimulus|response to purine-containing compound	molecular_function	nucleus|cytoplasm
YGR292W	YGR292W	MAL12	hom	Verified	1.23190095018971	0.108993043218459	no	514	0.0775189026935615	272	NA	FT	CARBOHYDRATE METABOLISM			Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose	sucrose catabolic process|maltose catabolic process	sucrose alpha-glucosidase activity|maltose alpha-glucosidase activity	plasma membrane
YLR213C	YLR213C	CRR1	hom	Verified	1.23141376695166	0.109084075288146	no	515	0.0911161672955067	331	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation	ascospore wall assembly	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	ascospore wall
YDR291W	YDR291W	HRQ1	hom	Verified	1.23013610827997	0.109323070268138	no	516	0.0983426451339291	378	NA	FT		NUCLEUS		3'-5'DNA helicase that has DNA strand annealing activity; helicase activity is stimulated by fork structure and 3'-tail length of substrates; belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity; similar to the human RecQ4p implicated in Rothmund-Thomson syndrome(RTS)	biological_process	molecular_function	nucleus
YGL241W	YGL241W	KAP114	hom	Verified	1.22891427644994	0.109551974087129	no	517	0.10738168505046	379	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS		Karyopherin, responsible for nuclear import of specific proteins; cargoes include Spt15p, Sua7p, histones H2A and H2B, and Nap1p; amino terminus shows similarity to those of other importins, particularly Cse1p; localization is primarily nuclear; function is regulated by sumoylation; protein abundance increases in response to DNA replication stress	protein import into nucleus|transcription factor import into nucleus	protein transporter activity	integral to membrane|nucleus|cytoplasm
YDR469W	YDR469W	SDC1	hom	Verified	1.22811603412542	0.109701706375163	no	518	0.137579770205697	482	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS		Subunit of the COMPASS (Set1C) complex, which methylates lysine 4 of histone H3 and is required in chromatin silencing at telomeres; contains a Dpy-30 domain that mediates interaction with Bre2p; similar to C. elegans and human DPY-30	histone H3-K4 methylation|chromatin silencing at telomere	histone methyltransferase activity (H3-K4 specific)	Set1C/COMPASS complex
YHR160C	YHR160C	PEX18	hom	Verified	1.22787368656798	0.109747194380086	no	519	0.11793458310391	479	NA	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION			Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex21p	protein import into peroxisome matrix	protein binding	cytosol|peroxisome
YPL264C_p	YPL264C	YPL264C	hom	Uncharacterized	1.22776293919449	0.109767985880209	no	520	0.0953109139746102	330	NA					Putative membrane protein of unknown function; physically interacts with Hsp82p; YPL264C is not an essential gene	biological_process	molecular_function	integral to membrane
YBR182C	YBR182C	SMP1	hom	Verified	1.22696552416546	0.109917774527722	no	521	0.097522535099088	398	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Putative transcription factor of the MADS-box family; involved in regulating the response to osmotic stress; SMP1 has a paralog, RLM1, that arose from the whole genome duplication	positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress	DNA binding, bending|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus|cytoplasm
YCR101C_p	YCR101C	YCR101C	hom	Uncharacterized	1.22390284618643	0.110494439903646	no	522	0.111486045664536	470	NA					Putative protein of unknown function; localizes to the membrane fraction; YCR101C is not an essential gene	biological_process	molecular_function	integral to membrane|membrane
YLR209C	YLR209C	PNP1	hom	Verified	1.22319693948096	0.110627660635498	no	523	0.120267099488093	406	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			Purine nucleoside phosphorylase, specifically metabolizes inosine and guanosine nucleosides; involved in the nicotinamide riboside salvage pathway	guanosine catabolic process|inosine catabolic process|NAD biosynthesis via nicotinamide riboside salvage pathway|nicotinate nucleotide salvage	nicotinamide riboside hydrolase activity|inosine nucleosidase activity|purine-nucleoside phosphorylase activity	intracellular
YDL033C	YDL033C	SLM3	hom	Verified	1.22285096580665	0.110692995797581	no	524	0.130049704188165	466	NA	FT	RNA PROCESSING|MITOCHONDRION ORGANIZATION	MITOCHONDRION		tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF)	mitochondrial tRNA thio-modification	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity	mitochondrion
YOL103W	YOL103W	ITR2	hom	Verified	1.2207988712703	0.111081090645469	no	525	0.112876866176104	402	NA	FT		PLASMA MEMBRANE		Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively	myo-inositol transport	myo-inositol transmembrane transporter activity	integral to membrane|plasma membrane|membrane
YOR091W	YOR091W	TMA46	hom	Verified	1.21958249030857	0.111311593708861	no	526	0.120926603339357	443	NA	FT	TRANSLATION			Protein of unknown function that associates with translating ribosomes; interacts with GTPase Rbg1p	cytoplasmic translation	molecular_function	polysomal ribosome|ribosome|cytoplasm
YIL134C-A_p	YIL134C-A	YIL134C-A	hom	Uncharacterized	1.21769443941709	0.1116700554684	no	527	0.10264108345038	422	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YDR530C	YDR530C	APA2	hom	Verified	1.21595991749884	0.112000095659712	no	528	0.064456014016684	248	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication	nucleoside catabolic process	bis(5'-nucleosyl)-tetraphosphatase activity	nucleus|cytoplasm
YKL096W	YKL096W	CWP1	hom	Verified	1.21539875051258	0.112107022179858	no	529	0.0927010163981523	360	NA	FT	MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS			Cell wall mannoprotein that localizes specifically to birth scars of daughter cells, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; required for propionic acid resistance	fungal-type cell wall organization|ascospore-type prospore membrane assembly	structural constituent of cell wall	fungal-type cell wall|cellular birth scar|prospore membrane
YJL196C	YJL196C	ELO1	hom	Verified	1.21452079659077	0.112274456635957	no	530	0.0843050210785555	332	NA	FT	KETONE METABOLISM|LIPID METABOLISM			Elongase I, medium-chain acyl elongase; catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids; ELO1 has a paralog, FEN1, that arose from the whole genome duplication	fatty acid elongation, unsaturated fatty acid	fatty acid elongase activity	integral to membrane|membrane
YGR249W	YGR249W	MGA1	hom	Verified	1.21324508274948	0.112518066195959	no	531	0.117043975822322	456	NA	FT		NUCLEUS		Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants	filamentous growth	sequence-specific DNA binding|DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YPR092W_d	YPR092W	YPR092W	hom	Dubious	1.21234045031668	0.112691042920492	no	532	0.122949148591329	434	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGR257C	YGR257C	MTM1	hom	Verified	1.20970655631654	0.113195756590019	no	533	0.149735261353263	578	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor	manganese ion transport|transport	transporter activity|metallochaperone activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YHR006W	YHR006W	STP2	hom	Verified	1.20901760621166	0.113328040706332	no	534	0.0939692551253219	390	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS|PLASMA MEMBRANE		Transcription factor; activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes; STP2 has a paralog, STP1, that arose from the whole genome duplication	positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|cytoplasm
YLR454W_p	YLR454W	FMP27	hom	Uncharacterized	1.20879504526939	0.113370797802656	no	535	0.103710758607272	438	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YMR096W	YMR096W	SNZ1	hom	Verified	1.20853865180672	0.113420068864152	no	536	0.0853125680112172	293	NA	FT	COFACTOR METABOLISM			Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins	pyridoxine metabolic process|thiamine biosynthetic process	protein binding	cellular_component
YBR162C	YBR162C	TOS1	hom	Verified	1.20603817893495	0.113901384888059	no	537	0.105917664036698	407	NA					Covalently-bound cell wall protein of unknown function; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C	biological_process	molecular_function	fungal-type cell wall|fungal-type vacuole
YNL265C	YNL265C	IST1	hom	Verified	1.20403209909083	0.11428858609398	no	538	0.125249878933524	478	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT			Protein with a positive role in the multivesicular body sorting pathway; functions and forms a complex with Did2p; recruitment to endosomes is mediated by the Vps2p-Vps24p subcomplex of ESCRT-III; also interacts with Vps4p	late endosome to vacuole transport via multivesicular body sorting pathway	molecular_function	endosome|cytoplasm
YER028C	YER028C	MIG3	hom	Verified	1.20254826854142	0.114575588358724	no	539	0.111358004229952	433	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Transcriptional regulator; partially nonfunctional in S288C strains but has a major role in catabolite repression and ethanol response in some other strains; involved in response to toxic agents; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes; MIG3 has a paralog, MIG2, that arose from the whole genome duplication	cellular response to UV|negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|response to DNA damage stimulus	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding	nuclear chromatin
YBR196C-A_p	YBR196C-A	YBR196C-A	hom	Uncharacterized	1.20171115558207	0.114737728750571	no	540	0.148510394748969	512	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YNL097C-B_p	YNL097C-B	YNL097C-B	hom	Uncharacterized	1.20024380752119	0.115022333126484	no	541	0.0928626919743665	331	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YAR027W	YAR027W	UIP3	hom	Verified	1.20006552293508	0.115056947081645	no	542	0.111203280707652	377	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS|PLASMA MEMBRANE		Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family	biological_process	molecular_function	nuclear envelope
YER011W	YER011W	TIR1	hom	Verified	1.19890975231289	0.115281519627846	no	543	0.0931982721779153	365	NA					Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking	response to stress	structural constituent of cell wall	fungal-type cell wall
YBL039W-B_p	YBL039W-B	YBL039W-B	hom	Uncharacterized	1.19802957839936	0.11545275109126	no	544	0.101096159274131	379	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YDR194W-A_p	YDR194W-A	YDR194W-A	hom	Uncharacterized	1.19792673799391	0.115472769733635	no	545	0.13787730716042	480	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YGL181W	YGL181W	GTS1	hom	Verified	1.19576905343918	0.115893347780984	no	546	0.11876298557818	369	NA	FT	VESICLE-MEDIATED TRANSPORT|TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM|MEMBRANE ORGANIZATION|SIGNALING|NUCLEOTIDE METABOLISM	NUCLEUS|CYTOSKELETON		Protein involved in Arf3p regulation and in transcription regulation; localizes to the nucleus and to endocytic patches; contains an N-terminal Zn-finger and ArfGAP homology domain, a C-terminal glutamine-rich region, and a UBA (ubiquitin associated) domain; gts1 mutations affect budding, cell size, heat tolerance, sporulation, life span, ultradian rhythms, endocytosis; expression oscillates in a pattern similar to metabolic oscillations	endocytosis|ultradian rhythm|regulation of transcription from RNA polymerase II promoter|negative regulation of phosphatidylinositol biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	ARF GTPase activator activity|repressing transcription factor binding|transcription factor binding transcription factor activity	nucleus|cytoplasm|actin cortical patch
YML036W	YML036W	CGI121	hom	Verified	1.19240487550142	0.116551264754069	no	547	0.138382600423024	475	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS|CHROMOSOME		Component of the EKC/KEOPS complex with Bud32p, Kae1p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription; Cgi121p is dispensable for tRNA modification	telomere maintenance|positive regulation of transcription from RNA polymerase II promoter	molecular_function	EKC/KEOPS complex
YLR373C	YLR373C	VID22	hom	Verified	1.19162341625324	0.11670446955866	no	548	0.134011753865507	532	NA	FT	PROTEIN LOCALIZATION	NUCLEUS|PLASMA MEMBRANE		Glycosylated integral membrane protein localized to the plasma membrane; plays a role in fructose-1,6-bisphosphatase (FBPase) degradation; involved in FBPase transport from the cytosol to Vid (vacuole import and degradation) vesicles	vacuolar protein catabolic process	molecular_function	integral to plasma membrane
YLR113W	YLR113W	HOG1	hom	Verified	1.18998333012972	0.117026472026826	no	549	0.143424936111919	433	NA	FT	TRANSCRIPTION FROM RNA POL II|SIGNALING|PROTEIN PHOSPHORYLATION	NUCLEUS		Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNA Pol II in response to osmotic shock; acts via three independent osmosensors; mitophagy-specific regulator; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p; protein abundance increases in response to DNA replication stress	negative regulation of transcription from RNA polymerase II promoter by pheromones|protein phosphorylation|hyperosmotic response|response to arsenic-containing substance|osmosensory signaling pathway|positive regulation of transcription from RNA polymerase II promoter|cellular response to heat	MAP kinase activity	nucleus|cytoplasm
YOL050C_d	YOL050C	YOL050C	hom	Dubious	1.18970715623063	0.117080755854692	no	550	0.135607858962597	502	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)	Unknown	Unknown	Unknown
YOR223W	YOR223W	YOR223W	hom	Verified	1.18921970407278	0.117176611368473	no	551	0.117933212014178	450	NA	FT		ENDOPLASMIC RETICULUM		Subunit of the DSC ubiquitin ligase complex; protein of unknown function that localizes to the ER and vacuole lumen; overexpression affects endocytic protein trafficking; ortholog of fission yeast dsc3	biological_process	molecular_function	fungal-type vacuole lumen|endoplasmic reticulum
YPL185W_d	YPL185W	YPL185W	hom	Dubious	1.18610782303571	0.117789860754662	no	552	0.124434401621597	400	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C	Unknown	Unknown	Unknown
YML050W	YML050W	AIM32	hom	Verified	1.18472639886913	0.118062820651486	no	553	0.136490971022308	483	NA					Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	cellular_component
YJR107W_p	YJR107W	YJR107W	hom	Uncharacterized	1.18200801364094	0.118601260578668	no	554	0.110099302327963	394	NA	FT	LIPID METABOLISM			Putative lipase	biological_process	lipase activity	cellular_component
YMR184W	YMR184W	ADD37	hom	Verified	1.17905338581761	0.119188459251586	no	555	0.119097185975975	391	NA	FT	PROTEOLYSIS			Protein of unknown function; involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene; protein abundance increases in response to DNA replication stress	ER-associated protein catabolic process	molecular_function	cytoplasm
YGR038W	YGR038W	ORM1	hom	Verified	1.17790219956294	0.119417799052341	no	556	0.155223236636669	519	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Evolutionarily conserved protein, similar to Orm2p, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control	cellular sphingolipid homeostasis|negative regulation of sphingolipid biosynthetic process|response to unfolded protein	molecular_function	integral to membrane|endoplasmic reticulum|SPOTS complex
YJR073C	YJR073C	OPI3	hom	Verified	1.17777627459635	0.119442904756035	no	557	0.167185838836599	625	NA	FF|FT	LIPID METABOLISM	MITOCHONDRION		Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis	phosphatidylcholine biosynthetic process	phosphatidyl-N-dimethylethanolamine N-methyltransferase activity|phosphatidyl-N-methylethanolamine N-methyltransferase activity	mitochondrion|integral to membrane
YLR377C	YLR377C	FBP1	hom	Verified	1.17535887322676	0.119925584974283	no	558	0.124381099219665	460	NA	FT	CARBOHYDRATE METABOLISM			Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism; undergoes either proteasome-mediated or autophagy-mediated degradation depending on growth conditions; interacts with Vid30p	gluconeogenesis|reactive oxygen species metabolic process	fructose 1,6-bisphosphate 1-phosphatase activity	cytosol
YHR032W	YHR032W	ERC1	hom	Verified	1.17456726696322	0.120083942689585	no	559	0.121066381531871	412	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM			Member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily; overproduction confers ethionine resistance and accumulation of S-adenosylmethionine	S-adenosylmethionine biosynthetic process|transmembrane transport	antiporter activity	integral to membrane
YDR371W_p	YDR371W	CTS2	hom	Uncharacterized	1.17239106168938	0.120520043226304	no	560	0.106071779120442	368	NA	FT	CARBOHYDRATE METABOLISM			Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect	sporulation resulting in formation of a cellular spore	molecular_function	cytoplasm
YML019W	YML019W	OST6	hom	Verified	1.17182596698178	0.120633467523379	no	561	0.131891890134627	503	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p	protein N-linked glycosylation via asparagine|protein complex assembly	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	oligosaccharyltransferase complex|integral to membrane
YLL038C	YLL038C	ENT4	hom	Verified	1.17053440164363	0.120892989187372	no	562	0.0693417924368379	264	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION	CYTOSKELETON		Protein of unknown function, contains an N-terminal epsin-like domain; proposed to be involved in the trafficking of Arn1p in the absence of ferrichrome	endocytosis|actin filament organization|establishment of protein localization to plasma membrane|actin cortical patch assembly	clathrin binding	actin cortical patch
YDL122W	YDL122W	UBP1	hom	Verified	1.17005438368356	0.120989542035518	no	563	0.11368915731335	452	NA	FT	PROTEOLYSIS	ENDOPLASMIC RETICULUM		Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains	protein deubiquitination	ubiquitin-specific protease activity	endoplasmic reticulum|cytoplasm
YHR043C	YHR043C	DOG2	hom	Verified	1.16072281030494	0.122877321236629	no	564	0.125833558815441	424	NA	FT	CARBOHYDRATE METABOLISM	NUCLEUS		2-deoxyglucose-6-phosphate phosphatase; member of a family of low molecular weight phosphatases, paralogous to DOG1, induced by oxidative and osmotic stress, confers 2-deoxyglucose resistance when overexpressed	glucose metabolic process	2-deoxyglucose-6-phosphatase activity	nucleus|cytoplasm
YBR222C	YBR222C	PCS60	hom	Verified	1.15983679537361	0.123057629988685	no	565	0.0920590583646507	367	NA					Peroxisomal protein that binds AMP and mRNA, localizes to both the peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid, similar to E. coli long chain acyl-CoA synthetase	biological_process	mRNA binding|AMP binding	integral to membrane|peroxisomal matrix|peroxisomal membrane|cytoplasm
YPL201C	YPL201C	YIG1	hom	Verified	1.1557143572337	0.123899006802551	no	566	0.126848151279849	487	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol	glycerol biosynthetic process	molecular_function	cytosol|nucleus
YER044C	YER044C	ERG28	hom	Verified	1.15531206252663	0.123981329017862	no	567	0.134195967689429	500	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Endoplasmic reticulum membrane protein, may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER, also interacts with Erg6p	ergosterol biosynthetic process	protein binding, bridging	endoplasmic reticulum membrane
YJR118C	YJR118C	ILM1	hom	Verified	1.15416872570012	0.124215500833972	no	568	0.164047936319772	596	NA	FF|FT	MITOCHONDRION ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth	mitochondrial genome maintenance	molecular_function	integral to membrane|endoplasmic reticulum
YOR385W_p	YOR385W	YOR385W	hom	Uncharacterized	1.15410849975668	0.124227844545085	no	569	0.126387972146097	494	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YOR385W is not an essential gene	biological_process	molecular_function	cytoplasm
YGL094C	YGL094C	PAN2	hom	Verified	1.15395466437593	0.124259378033185	no	570	0.13610548261677	480	NA	FT	RNA PROCESSING|RESPONSE TO DNA DAMAGE|PROTEOLYSIS			Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes	mRNA 3'-end processing|postreplication repair|mRNA processing	poly(A)-specific ribonuclease activity	PAN complex|cytoplasm
YNL286W	YNL286W	CUS2	hom	Verified	1.1526639426529	0.124524173348116	no	571	0.127972491941673	495	NA	FT	RNA PROCESSING	NUCLEUS		Protein that binds to U2 snRNA and Prp11p, may be involved in U2 snRNA folding; contains two RNA recognition motifs (RRMs)	mRNA splicing, via spliceosome	RNA binding	U2 snRNP
YDR363W-A	YDR363W-A	SEM1	hom	Verified	1.15080560505228	0.124906109183036	no	572	0.130199768987613	505	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|PROTEOLYSIS|RNA LOCALIZATION	NUCLEUS		Component of lid subcomplex of the 26S proteasome regulatory subunit; involved in mRNA export mediated by the TREX-2 complex (Sac3p-Thp1p); ortholog of human DSS1; protein abundance increases in response to DNA replication stress	proteasome assembly|proteasomal ubiquitin-dependent protein catabolic process|regulation of cell cycle|mRNA export from nucleus|exocytosis|filamentous growth|ubiquitin-dependent protein catabolic process	molecular_function	cytosol|nucleus|proteasome storage granule|proteasome regulatory particle, lid subcomplex
YER068C-A_d	YER068C-A	YER068C-A	hom	Dubious	1.15050597375861	0.124967767602735	no	573	0.117592332659552	392	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YAL066W_d	YAL066W	YAL066W	hom	Dubious	1.14905284971588	0.125267094469841	no	574	0.147854868009501	437	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOR214C_p	YOR214C	YOR214C	hom	Uncharacterized	1.1488980160148	0.125299017919512	no	575	0.117128849203576	389	NA					Putative protein of unknown function; YOR214C is not an essential gene	biological_process	molecular_function	fungal-type cell wall
YOR219C	YOR219C	STE13	hom	Verified	1.14801625163086	0.125480927447578	no	576	0.131643060420743	462	NA	FT	PROTEOLYSIS	GOLGI APPARATUS		Dipeptidyl aminopeptidase, Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences, required for maturation of alpha factor, transcription is induced by a-factor	peptide pheromone maturation	aminopeptidase activity	trans-Golgi network
YOL116W	YOL116W	MSN1	hom	Verified	1.14763486570541	0.125559665102483	no	577	0.128563388102098	460	NA	FT	TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM	NUCLEUS		Transcriptional activator; involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress; localizes to the nucleus; relative distribution to the nucleus increases upon DNA replication stress	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription from RNA polymerase II promoter in response to methylglyoxal|positive regulation of transcription from RNA polymerase II promoter in response to increased salt|Unknown|positive regulation of starch catabolic process by positive regulation of transcription from RNA polymerase II promoter|positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding	nucleus
YGR122C-A_d	YGR122C-A	YGR122C-A	hom	Dubious	1.14323967856149	0.126469546115521	no	578	0.102451051783646	381	NA					Dubious open reading frame unlikely to encode a functional protein, similar to YLR334C and YOL106W	Unknown	Unknown	Unknown
YER024W	YER024W	YAT2	hom	Verified	1.14281457742561	0.126557792530262	no	579	0.120166375696195	387	NA	FT	KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM			Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane	carnitine metabolic process|alcohol metabolic process	carnitine O-acetyltransferase activity	cytosol|cytoplasm
YKL151C	YKL151C	YKL151C	hom	Verified	1.14216458518627	0.126692806826895	no	580	0.0954596876547814	339	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			NADHX dehydratase; converts (S)-NADHX to NADH in an ATP-dependent manner; homologous to Carkd in mammals, and the C-terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; YKL151C promoter contains STREs (stress response elements) and expression is induced by heat shock or methyl methanesulfonate; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress	nicotinamide nucleotide metabolic process	ATP-dependent NAD(P)H-hydrate dehydratase activity	cytoplasm
YDL112W	YDL112W	TRM3	hom	Verified	1.14207832380704	0.126710732299266	no	581	0.139430434627027	464	NA	FT	RNA PROCESSING			2'-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs	tRNA methylation	tRNA (guanine) methyltransferase activity	cytoplasm
YGL211W	YGL211W	NCS6	hom	Verified	1.14186555648262	0.126754953782029	no	582	0.132069804922163	488	NA	FT	RNA PROCESSING	MITOCHONDRION		Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae	tRNA wobble position uridine thiolation|protein urmylation|tRNA wobble uridine modification	tRNA binding	cytosol|mitochondrion
YPR032W	YPR032W	SRO7	hom	Verified	1.14126030700368	0.126880807371472	no	583	0.129547911539381	496	NA	FT	VESICLE-MEDIATED TRANSPORT|SIGNALING	PLASMA MEMBRANE		Effector of Rab GTPase Sec4p; forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lgl tumor suppressor; SRO7 has a paralog, SRO77, that arose from the whole genome duplication	establishment of cell polarity|exocytosis|Golgi to plasma membrane transport|small GTPase mediated signal transduction	SNARE binding|Rab GTPase binding	cytosol|plasma membrane
YDR100W	YDR100W	TVP15	hom	Verified	1.14036166224848	0.127067829029127	no	584	0.125906843914419	373	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p	vesicle-mediated transport	molecular_function	COPI-coated vesicle|integral to membrane|integral to Golgi membrane
YOR345C_d	YOR345C	YOR345C	hom	Dubious	1.14027433999187	0.127086012341474	no	585	0.123236393005097	440	NA					Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2	Unknown	Unknown	Unknown
YDR254W	YDR254W	CHL4	hom	Verified	1.13813777496536	0.12753147837181	no	586	0.124301052015265	420	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME	KINETOCHORE	Outer kinetochore protein required for chromosome stability; involved in new kinetochore assembly and sister chromatid cohesion; peripheral component of the Ctf19 kinetochore complex that interacts with Ctf19p, Ctf3p, Iml3p and Mif2p; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-N and fission yeast mis15	kinetochore assembly|chromosome segregation|establishment of meiotic sister chromatid cohesion|protein localization to chromosome, centromeric region|maintenance of meiotic sister chromatid cohesion|establishment of mitotic sister chromatid cohesion	structural molecule activity	condensed nuclear chromosome outer kinetochore
YMR044W	YMR044W	IOC4	hom	Verified	1.1336433349653	0.128472093817937	no	587	0.150508230636819	522	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS		Member of a complex (Isw1b) with Isw1p and Ioc2p; interacts directly with H3K36me3 nucleosomes through its PWWP domain to recruit the Isw1b complex to open reading frames in a Set2p-dependent manner; Isw1b exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing	chromatin remodeling	nucleosome binding|ATPase activity|DNA binding	ISW1 complex
YHR200W	YHR200W	RPN10	hom	Verified	1.13219536811653	0.128776153511095	no	588	0.129736197676844	510	NA	FT	PROTEOLYSIS			Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein	ubiquitin-dependent protein catabolic process	structural molecule activity|polyubiquitin binding	proteasome complex|proteasome regulatory particle, base subcomplex
YHR137W	YHR137W	ARO9	hom	Verified	1.13008990274112	0.129219171993515	no	589	0.118531819294305	434	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Aromatic aminotransferase II, catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism	aromatic amino acid family metabolic process	aromatic-amino-acid:2-oxoglutarate aminotransferase activity	nucleus|cytoplasm
YDR438W	YDR438W	THI74	hom	Verified	1.12457385669448	0.130384828594703	no	590	0.137082222531427	490	NA	FT		MITOCHONDRION		Mitochondrial transporter repressible by thiamine; THI74 has a paralog, YML018C, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrion|integral to membrane
YLR177W_p	YLR177W	YLR177W	hom	Uncharacterized	1.1245308858819	0.130393937691452	no	591	0.126160944427315	402	NA					Putative protein of unknown function; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; not an essential gene; YLR177W has a paralog, PSP1, that arose from the whole genome duplication	biological_process	molecular_function	cytoplasm
YGR112W	YGR112W	SHY1	hom	Verified	1.123100020934	0.130697508625002	no	592	0.100520643531921	358	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome	mitochondrial respiratory chain complex IV assembly|aerobic respiration	unfolded protein binding	mitochondrion|integral to membrane|mitochondrial inner membrane
YDL011C_d	YDL011C	YDL011C	hom	Dubious	1.12284523023205	0.130751615980623	no	593	0.117956769583961	411	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized ORF YDL010W	Unknown	Unknown	Unknown
YOR042W	YOR042W	CUE5	hom	Verified	1.12283013871156	0.130754821301694	no	594	0.140585754235903	494	NA					Protein containing a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	biological_process	ubiquitin binding	cytoplasm
YLR428C_d	YLR428C	YLR428C	hom	Dubious	1.12091007073778	0.1311630718635	no	595	0.137800784863229	533	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CRN1	Unknown	Unknown	Unknown
YEL048C	YEL048C	TCA17	hom	Verified	1.12014485570262	0.131326019265426	no	596	0.115165194400705	409	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS	GOLGI APPARATUS		Subunit of TRAPPII, a multimeric GEF involved in intra-Golgi and endosome-to-Golgi transport; promotes association of TRAPPII-specific subunits with the core complex; sedlin related; human Sedlin mutations cause SEDT, a skeletal disorder	early endosome to Golgi transport|protein complex assembly	molecular_function	TRAPP complex|Golgi apparatus|clathrin-coated vesicle
YMR125W	YMR125W	STO1	hom	Verified	1.11831253819167	0.131716766897043	no	597	0.151121086117002	526	NA	FT	RNA PROCESSING|RNA LOCALIZATION	NUCLEUS		Large subunit of the nuclear mRNA cap-binding protein complex, interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|mRNA splicing, via spliceosome|response to osmotic stress	mRNA binding	commitment complex|nuclear cap binding complex|polysome
YGL013C	YGL013C	PDR1	hom	Verified	1.11825774749592	0.131728463530133	no	598	0.255598227753354	918	NA	FF|FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS	RSC COMPLEX	Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication	Unknown|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YKL061W_p	YKL061W	BLI1	hom	Uncharacterized	1.11814010186032	0.131753580760199	no	599	0.117996194907929	401	NA					Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome	biological_process	molecular_function	endosome
YDR298C	YDR298C	ATP5	hom	Verified	1.11761557865542	0.13186560616852	no	600	0.146268050774382	534	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	MITOCHONDRION		Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated	ATP synthesis coupled proton transport	hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism	mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase, stator stalk|mitochondrial proton-transporting ATP synthase complex
YMR056C	YMR056C	AAC1	hom	Verified	1.11207933327885	0.133052020857707	no	601	0.122265743027479	481	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator; relocalizes from mitochondrion to cytoplasm upon DNA replication stress	heme biosynthetic process|mitochondrial transport|heme transport|aerobic respiration	ATP:ADP antiporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YLR395C	YLR395C	COX8	hom	Verified	1.11118490327739	0.133244384035628	no	602	0.152094820549304	532	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YOL031C	YOL031C	SIL1	hom	Verified	1.1107090724677	0.13334679791184	no	603	0.120901730812776	492	NA	FT	PROTEIN LOCALIZATION	ENDOPLASMIC RETICULUM		Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, required for protein translocation into the ER; homolog of Yarrowia lipolytica SLS1; GrpE-like protein	SRP-dependent cotranslational protein targeting to membrane, translocation	adenyl-nucleotide exchange factor activity	endoplasmic reticulum
YLR108C	YLR108C	YLR108C	hom	Verified	1.10721385178026	0.134100740044527	no	604	0.147959456714457	464	NA	FT		NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene; protein abundance increases in response to DNA replication stress; YLR108C has a paralog, YDR132C, that arose from the whole genome duplication	biological_process	molecular_function	nucleus
YJR003C_p	YJR003C	YJR003C	hom	Uncharacterized	1.10718202623506	0.134107618451663	no	605	0.135838009303491	480	NA	FT		MITOCHONDRION		Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; predicted to be involved in ribosome biogenesis	biological_process	molecular_function	mitochondrion
YLR027C	YLR027C	AAT2	hom	Verified	1.10652539197405	0.134249589916745	no	606	0.184554924618018	596	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells	aspartate biosynthetic process	L-aspartate:2-oxoglutarate aminotransferase activity	cytosol|peroxisome
YGR150C	YGR150C	CCM1	hom	Verified	1.10594464833999	0.13437523899398	no	607	0.15592551029285	518	NA	FT	RNA PROCESSING|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial 15s rRNA-binding protein; required for intron removal of COB and COX1 pre-mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport	rRNA metabolic process|mitochondrial RNA processing|mitochondrial genome maintenance	rRNA binding	mitochondrion
YJL185C	YJL185C	ATG36	hom	Verified	1.09997941214676	0.135670546105817	no	608	0.124810558667156	467	NA					Pex3p interacting protein, required for pexophagy; interacts with Atg8p and Atg11p; mRNA is weakly cell cycle regulated, peaking in G2 phase; YJL185C is a non-essential gene	peroxisome degradation	molecular_function	peroxisome
YJL046W	YJL046W	AIM22	hom	Verified	1.09949635438697	0.135775811633686	no	609	0.134213097188065	452	NA	FT		MITOCHONDRION		Putative lipoate-protein ligase, required along with Lip2 and Lip5 for lipoylation of Lat1p and Kgd2p; similar to E. coli LplA; null mutant displays reduced frequency of mitochondrial genome loss	protein lipoylation	lipoate-protein ligase activity	mitochondrion
YDR319C_p	YDR319C	YFT2	hom	Uncharacterized	1.09899483474143	0.135885159453648	no	610	0.133505791905297	502	NA					Protein required for normal ER membrane biosynthesis; member of the highly conserved FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; interacts with Sst2p and Hsp82p in high-throughput two-hybrid screens	biological_process	molecular_function	integral to membrane
YMR237W	YMR237W	BCH1	hom	Verified	1.09855936551132	0.135980155003817	no	611	0.144815099418452	530	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	GOLGI APPARATUS		Member of the ChAPs family (Chs5p-Arf1p-binding proteins); members include Bch1p, Bch2p, Bud7p, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p to mediate export of specific cargo proteins from the Golgi to the plasma membrane; may interact with ribosomes; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress; BCH1 has a paralog, BUD7, that arose from the whole genome duplication	Golgi to plasma membrane transport|fungal-type cell wall chitin biosynthetic process	molecular_function	ribosome|clathrin-coated vesicle|exomer complex
YFL013W-A_d	YFL013W-A	YFL013W-A	hom	Dubious	1.0973394219907	0.136246521958238	no	612	0.153503981414284	560	NA					Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps IES1/YFL013C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching	Unknown	Unknown	Unknown
YPR091C	YPR091C	NVJ2	hom	Verified	1.09717249601659	0.136282996939934	no	613	0.110671499881595	380	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments	biological_process	lipid binding	ribosome|nucleus-vacuole junction|endoplasmic reticulum
YPR096C	YPR096C	YPR096C	hom	Verified	1.09329232841794	0.137132735053899	no	614	0.117487722311411	428	NA					Protein of unknown function that may interact with ribosomes, based on co-purification experiments	biological_process	molecular_function	ribosome
YLR095C	YLR095C	IOC2	hom	Verified	1.09116538302841	0.137600058539497	no	615	0.134674537958272	468	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS		Member of a complex (Isw1b) with Isw1p and Ioc4p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PHD finger motif	chromatin remodeling	protein binding|nucleosome binding|ATPase activity|DNA binding	ISW1 complex
YPL219W	YPL219W	PCL8	hom	Verified	1.09036828385945	0.137775473510224	no	616	0.156020640925697	533	NA	FT	CELL CYCLE|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylation	negative regulation of glycogen biosynthetic process	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex
YJR154W_p	YJR154W	YJR154W	hom	Uncharacterized	1.08912070544092	0.138050330144917	no	617	0.128761198820511	470	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YPR153W	YPR153W	YPR153W	hom	Verified	1.0872461314123	0.138464024176129	no	618	0.120239142559176	420	NA					Putative protein of unknown function	biological_process	molecular_function	integral to membrane
YMR255W	YMR255W	GFD1	hom	Verified	1.0870188050653	0.138514249512224	no	619	0.129594644583789	480	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Coiled-coiled protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; protein abundance increases in response to DNA replication stress	mRNA export from nucleus	molecular_function	integral to membrane|nuclear pore|cytoplasm
YKR091W	YKR091W	SRL3	hom	Verified	1.08621218288682	0.138692564259897	no	620	0.142958941585156	546	NA					Cytoplasmic protein that, when overexpressed, suppresses the lethality of a rad53 null mutation; potential Cdc28p substrate	nucleobase-containing compound metabolic process	molecular_function	cytoplasm
YHR013C	YHR013C	ARD1	hom	Verified	1.08370885571991	0.139246953944689	no	621	0.138627648944284	541	NA	FT	CHROMATIN ORGANIZATION		RIBOSOME	Subunit of protein N-terminal acetyltransferase NatA; NatA is comprised of Nat1p, Ard1p, and Nat5p; acetylates many proteins and thus affects telomeric silencing, cell cycle, heat-shock resistance, mating, and sporulation; human Ard1p levels are elevated in cancer cells; protein abundance increases in response to DNA replication stress	histone acetylation|N-terminal protein amino acid acetylation	peptide alpha-N-acetyltransferase activity	cytosolic ribosome|NatA complex
YGR143W	YGR143W	SKN1	hom	Verified	1.08352143276124	0.139288521437978	no	622	0.163854299348696	539	NA	FT	LIPID METABOLISM|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Protein involved in sphingolipid biosynthesis; type II membrane protein with similarity to Kre6p	fungal-type cell wall organization|(1->6)-beta-D-glucan biosynthetic process|sphingolipid biosynthetic process	glucosidase activity	integral to membrane
YBL028C	YBL028C	YBL028C	hom	Verified	1.08264691360487	0.139482587768192	no	623	0.161896898241822	498	NA	FT		NUCLEUS		Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis	biological_process	molecular_function	ribosome|nucleolus|nucleus|preribosome, large subunit precursor
YBL085W	YBL085W	BOI1	hom	Verified	1.07779896690857	0.140561740346699	no	624	0.132448452257276	502	NA	FT	SIGNALING|CELL DIVISION	SITE OF POLARIZED GROWTH		Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication	cytokinesis, completion of separation|establishment of cell polarity|budding cell apical bud growth|Rho protein signal transduction	phospholipid binding	site of polarized growth|cellular bud|mating projection tip|cellular bud neck
YMR123W	YMR123W	PKR1	hom	Verified	1.07569494422371	0.141031854642931	no	625	0.209877099207377	703	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		V-ATPase assembly factor; functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); protein abundance increases in response to DNA replication stress	vacuolar proton-transporting V-type ATPase complex assembly	molecular_function	integral to endoplasmic reticulum membrane
YPL052W	YPL052W	OAZ1	hom	Verified	1.07535096783327	0.14110881263194	no	626	0.130548510209973	485	NA	FT	TRANSLATION|PROTEOLYSIS			Regulator of ornithine decarboxylase (Spe1p), antizyme that binds to Spe1p to stimulate ubiquitin-independent degradation by the proteasome; binding of polyamines to nascent Oaz1p during translation stimulates +1 ribosomal frameshifting, allowing translation of full-length Oaz1p	Unknown|regulation of proteasomal protein catabolic process	ornithine decarboxylase inhibitor activity	cytoplasm
YOR222W	YOR222W	ODC2	hom	Verified	1.07496811019303	0.1411945030211	no	627	0.120478662807432	476	NA	FT		MITOCHONDRION		Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism	mitochondrial transport	dicarboxylic acid transmembrane transporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YER077C_p	YER077C	YER077C	hom	Uncharacterized	1.07328591384857	0.141571426665583	no	628	0.184395769161607	621	NA	FT		MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport	biological_process	molecular_function	mitochondrion
YGL078C	YGL078C	DBP3	hom	Verified	1.07279952177661	0.141680537714635	no	629	0.153498817751282	536	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		RNA-Dependent ATPase, member of DExD/H-box family; involved in cleavage of site A3 within the ITS1 spacer during rRNA processing; not essential for growth, but deletion causes severe slow-growth phenotype	endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	RNA-dependent ATPase activity	nucleolus|preribosome, large subunit precursor
YGL041C_d	YGL041C	YGL041C	hom	Dubious	1.07052856522638	0.142190729138963	no	630	0.155848730266148	557	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YAR015W	YAR015W	ADE1	hom	Verified	1.06978927344766	0.142357085806979	no	631	0.140201727200959	521	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase, required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine; protein abundance increases in response to DNA replication stress	purine nucleotide biosynthetic process|'de novo' IMP biosynthetic process	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity	nucleus|cytoplasm
YJL116C	YJL116C	NCA3	hom	Verified	1.06854148541165	0.142638163709298	no	632	0.126067490272141	400	NA	FT	MITOCHONDRION ORGANIZATION	MITOCHONDRION		Protein involved in mitochondrion organization; functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; member of the SUN family; expression induced in cells treated with the mycotoxin patulin; NCA3 has a paralog, UTH1, that arose from the whole genome duplication	mitochondrion organization	molecular_function	cellular_component
YDR370C	YDR370C	DXO1	hom	Verified	1.06634477122029	0.143133908893032	no	633	0.136959250729293	485	NA					Protein with decapping and 5′-3′ exoRNase activity; similar to Rai1p	biological_process	molecular_function	cytoplasm
YDL239C	YDL239C	ADY3	hom	Verified	1.06561215623783	0.143299500859398	no	634	0.133923333498446	412	NA	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|MITOCHONDRION ORGANIZATION	NUCLEUS|CYTOSKELETON		Protein required for spore wall formation; thought to mediate assembly of a Don1p-containing structure at the leading edge of the prospore membrane via interaction with spindle pole body components; potentially phosphorylated by Cdc28p; ADY3 has a paralog, CNM67, that arose from the whole genome duplication	mitochondrion inheritance|ascospore wall assembly|sporulation resulting in formation of a cellular spore	molecular_function	spindle pole body|prospore membrane
YBL088C	YBL088C	TEL1	hom	Verified	1.0623985444101	0.144027397160453	no	635	0.139142595034629	482	NA	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION	NUCLEUS|MITOCHONDRION|CHROMOSOME		Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; regulates P-body formation induced by replication stress; homolog of human ataxia-telangiectasia mutated (ATM) gene, the gene responsible for ataxia telangiectasia (AT) (OMIM 607585)	double-strand break repair|histone phosphorylation|telomere maintenance|response to DNA damage stimulus|phosphorylation|DNA damage induced protein phosphorylation	protein kinase activity|telomeric DNA binding	mitochondrion|nucleus
YPR017C	YPR017C	DSS4	hom	Verified	1.06178018923796	0.144167742705679	no	636	0.153233631555462	589	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING			Guanine nucleotide dissociation stimulator for Sec4p, functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol	post-Golgi vesicle-mediated transport	zinc ion binding|guanyl-nucleotide exchange factor activity	cytosol|membrane
YGL190C	YGL190C	CDC55	hom	Verified	1.0617462771451	0.144175442260852	no	637	0.209039723481053	725	NA	FT	CELL CYCLE|SIGNALING	NUCLEUS|SITE OF POLARIZED GROWTH		Non-essential regulatory subunit B of protein phosphatase 2A (PP2A); localization to the cytoplasm requires Zds1p and Zds2p and promotes mitotic entry; localization to the nucleus prevents mitotic exit; required for correct nuclear division and chromosome segregation in meiosis; maintains nucleolar sequestration of Cdc14p during early meiosis; limits formation of PP2A-Rts1p holocomplexes to ensure timely dissolution of sister chromosome cohesion	negative regulation of exit from mitosis|positive regulation of G2/M transition of mitotic cell cycle|cell shape checkpoint|protein dephosphorylation	protein phosphatase type 2A regulator activity	nucleus|cellular bud neck|cytoplasm|cellular bud tip
YKL092C	YKL092C	BUD2	hom	Verified	1.05884282534404	0.144835683199602	no	638	0.136723924331759	460	NA	FT	CELL CYCLE|SIGNALING|CELL DIVISION|NUCLEOTIDE METABOLISM	PLASMA MEMBRANE		GTPase activating factor for Rsr1p/Bud1p; required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types; mutant deficient in mitotic spindle position checkpoint	bipolar cellular bud site selection|small GTPase mediated signal transduction|filamentous growth|cellular bud site selection|axial cellular bud site selection	GTPase activator activity|Ras GTPase activator activity	intracellular
YBR269C_p	YBR269C	FMP21	hom	Uncharacterized	1.05802900686908	0.145021109131483	no	639	0.147028485595993	517	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YGL230C_p	YGL230C	YGL230C	hom	Uncharacterized	1.057702969183	0.145095440586912	no	640	0.122169768424249	428	NA					Putative protein of unknown function; non-essential gene	biological_process	molecular_function	cellular_component
YDL123W	YDL123W	SNA4	hom	Verified	1.05739044670133	0.145166714854258	no	641	0.160485781705739	468	NA					Protein of unknown function, localized to the vacuolar outer membrane; predicted to be palmitoylated	biological_process	molecular_function	fungal-type vacuole lumen|fungal-type vacuole membrane
YHR182W	YHR182W	YHR182W	hom	Verified	1.0545247545391	0.14582136664126	no	642	0.167101738942627	506	NA	FT	SIGNALING			Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm; relocalizes from bud neck to cytoplasm upon DNA replication stress	biological_process	molecular_function	cytoplasm
YPL260W	YPL260W	YPL260W	hom	Verified	1.0523406818409	0.146321636597779	no	643	0.170800181160921	587	NA	FT		NUCLEUS		Putative substrate of cAMP-dependent protein kinase (PKA); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YPL260W is not an essential gene; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YMR064W	YMR064W	AEP1	hom	Verified	1.05101345110316	0.146626206019451	no	644	0.179866543915972	613	NA	FT	TRANSLATION	MITOCHONDRION		Protein required for expression of the mitochondrial OLI1 gene encoding subunit 9 of F1-F0 ATP synthase	regulation of translation	translation regulator activity	mitochondrion
YPL102C_d	YPL102C	YPL102C	hom	Dubious	1.05085660058287	0.146662227754383	no	645	0.14583370149969	516	NA					Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation enhances replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene ELP4	Unknown	Unknown	Unknown
YDR266C	YDR266C	HEL2	hom	Verified	1.05058057535196	0.146725633150461	no	646	0.152540874914516	483	NA					RING finger ubiquitin ligase (E3); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; computational analysis suggests a role as a transcription factor	biological_process	molecular_function	ribosome|cytoplasm
YDL093W	YDL093W	PMT5	hom	Verified	1.04989815176807	0.146882470717387	no	647	0.152719772090304	499	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt3p, can instead interact with Pmt2p in some conditions; target for new antifungals	protein O-linked mannosylation	dolichyl-phosphate-mannose-protein mannosyltransferase activity	integral to membrane|dolichyl-phosphate-mannose-protein mannosyltransferase complex
YDL188C	YDL188C	PPH22	hom	Verified	1.04896657261409	0.14709675177148	no	648	0.146378571527462	497	NA	FT	CELL CYCLE|TRANSLATION|CELL DIVISION|CYTOSKELETON ORGANIZATION	NUCLEUS|CHROMOSOME		Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; PPH22 has a paralog, PPH21, that arose from the whole genome duplication	actin filament organization|budding cell bud growth|G1/S transition of mitotic cell cycle|protein dephosphorylation|mitotic cell cycle spindle assembly checkpoint|regulation of translation	protein serine/threonine phosphatase activity	condensed nuclear chromosome, centromeric region
YPL092W	YPL092W	SSU1	hom	Verified	1.04703971757351	0.147540630160399	no	649	0.149674188171203	447	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein	sulfite transport	sulfite transmembrane transporter activity	integral to membrane|plasma membrane
YBR043C	YBR043C	QDR3	hom	Verified	1.04591012917971	0.14780126365398	no	650	0.125627555200688	471	NA	FT		PLASMA MEMBRANE		Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; has a role in polyamine homeostasis; expression is upregulated under polyamine stress; required for resistance to quinidine, barban, cisplatin, and bleomycin	drug transmembrane transport|polyamine homeostasis	drug transmembrane transporter activity|polyamine transmembrane transporter activity	integral to membrane|plasma membrane
YKR032W_d	YKR032W	YKR032W	hom	Dubious	1.04528253819428	0.147946202844541	no	651	0.128243314974612	468	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YHR059W	YHR059W	FYV4	hom	Verified	1.04430954107407	0.148171099999956	no	652	0.136799151188487	511	NA	FT		MITOCHONDRION		Protein of unknown function, required for survival upon exposure to K1 killer toxin	biological_process	molecular_function	mitochondrion
YBL044W_p	YBL044W	YBL044W	hom	Uncharacterized	1.04413337993532	0.148211842076287	no	653	0.14452430974583	496	NA					Putative protein of unknown function; YBL044W is not an essential protein	biological_process	molecular_function	cellular_component
YLR084C	YLR084C	RAX2	hom	Verified	1.0426147728802	0.148563372241544	no	654	0.174809419732856	532	NA	FT	CELL CYCLE|CELL DIVISION	MITOCHONDRION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p; RAX2 mRNA stability is regulated by Mpt5p	cellular bud site selection	molecular_function	mitochondrion|cellular bud scar|cellular bud neck|membrane
YAR020C	YAR020C	PAU7	hom	Verified	1.04191044119912	0.148726601414216	no	655	0.148352965572035	496	NA					Member of the seripauperin multigene family, active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme	biological_process	molecular_function	cellular_component
YIL148W	YIL148W	RPL40A	hom	Verified	1.04006042168209	0.149155914996204	no	656	0.155545884197539	533	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RESPONSE TO DNA DAMAGE|TRANSLATION	NUCLEUS	RIBOSOME	Ubiquitin-ribosomal 60S subunit protein L40A fusion protein; cleaved to yield ubiquitin and ribosomal protein L40A; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40A has a paralog, RPL40B, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress	cytoplasmic translation|protein ubiquitination|ribosome biogenesis	structural constituent of ribosome|protein tag	cytosolic large ribosomal subunit
YJR125C	YJR125C	ENT3	hom	Verified	1.04001941078433	0.149165441309434	no	657	0.148493667830101	491	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS|CYTOSKELETON		Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p	late endosome to vacuole transport via multivesicular body sorting pathway|early endosome to Golgi transport|actin filament organization|endocytosis|actin cortical patch assembly|Golgi to endosome transport	protein binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding	clathrin vesicle coat|actin cortical patch
YNL228W_d	YNL228W	YNL228W	hom	Dubious	1.03760394907441	0.149727239315176	no	658	0.172286881279382	607	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF YNL227C/JJJ1	Unknown	Unknown	Unknown
YGR268C	YGR268C	HUA1	hom	Verified	1.03732066080997	0.149793220025496	no	659	0.166788257198155	589	NA					Cytoplasmic protein containing a zinc finger domain with sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly	biological_process	molecular_function	cytoplasm
YLR019W	YLR019W	PSR2	hom	Verified	1.03368287126219	0.150642221617945	no	660	0.148971022421391	508	NA	FT		PLASMA MEMBRANE		Functionally redundant Psr1p homolog, a plasma membrane phosphatase involved in the general stress response; required with Psr1p and Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p	response to stress	phosphoprotein phosphatase activity	plasma membrane
YMR042W	YMR042W	ARG80	hom	Verified	1.03360842001242	0.150659630740476	no	661	0.146156525074326	479	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Transcription factor involved in regulation of arginine-responsive genes; acts with Arg81p and Arg82p	Unknown|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding	nucleus
YDR536W	YDR536W	STL1	hom	Verified	1.03360511276464	0.1506604041136	no	662	0.151735866819651	562	NA	FT		PLASMA MEMBRANE		Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock	transport|glycerol transport|transmembrane transport	solute:hydrogen symporter activity|transporter activity	integral to membrane|plasma membrane|membrane
YGL027C	YGL027C	CWH41	hom	Verified	1.03217432376357	0.150995230519959	no	663	0.175635211045995	607	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Processing alpha glucosidase I, ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress	fungal-type cell wall biogenesis|protein N-linked glycosylation	mannosyl-oligosaccharide glucosidase activity	endoplasmic reticulum membrane
YGR040W	YGR040W	KSS1	hom	Verified	1.03138005510654	0.151181315071235	no	664	0.141729633341767	529	NA	FT	CELL CYCLE|SIGNALING|PROTEIN PHOSPHORYLATION	NUCLEUS		Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains	pheromone-dependent signal transduction involved in conjugation with cellular fusion|signal transduction involved in filamentous growth|negative regulation of sequence-specific DNA binding transcription factor activity|protein phosphorylation|invasive growth in response to glucose limitation	MAP kinase activity|protein kinase activity|transcription factor binding	nucleus
YOR059C	YOR059C	YOR059C	hom	Verified	1.02898663852942	0.151742976805123	no	665	0.130097392741279	499	NA	FT	LIPID METABOLISM			Lipid particle protein of unknown function; contains a putative lipase serine active site; induced by transcription factor Rpn4p; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	lipid particle
YOL023W	YOL023W	IFM1	hom	Verified	1.02770521186938	0.152044257723809	no	666	0.17893826644608	649	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial translation initiation factor 2	translational initiation|mitochondrial translational initiation|mitochondrial translation	tRNA binding|GTPase activity|translation initiation factor activity	mitochondrion
YJR079W_p	YJR079W	YJR079W	hom	Uncharacterized	1.02576749937586	0.152500594523447	no	667	0.169603165278306	548	NA					Putative protein of unknown function; mutation results in impaired mitochondrial respiration	biological_process	molecular_function	cellular_component
YBR024W	YBR024W	SCO2	hom	Verified	1.02518269395068	0.152638496217031	no	668	0.146987125283906	518	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Protein anchored to mitochondrial inner membrane; may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p; SCO2 has a paralog, SCO1, that arose from the whole genome duplication	copper ion transport	thioredoxin peroxidase activity	mitochondrial envelope|mitochondrion
YLR238W	YLR238W	FAR10	hom	Verified	1.02475817908926	0.152738651947933	no	669	0.147502776821155	522	NA	FT	CELL CYCLE|SIGNALING	ENDOPLASMIC RETICULUM		Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far11p; potential Cdc28p substrate	re-entry into mitotic cell cycle after pheromone arrest	molecular_function	endoplasmic reticulum
YGL028C	YGL028C	SCW11	hom	Verified	1.02350955671568	0.153033491849267	no	670	0.164260982280885	559	NA	FT	CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM			Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p	cytokinesis, completion of separation	glucan endo-1,3-beta-D-glucosidase activity	fungal-type cell wall
YNL085W	YNL085W	MKT1	hom	Verified	1.02339005603049	0.153061729573392	no	671	0.147460446638232	546	NA	FT	RESPONSE TO DNA DAMAGE|TRANSLATION			Protein that forms a complex with Pbp1p; complex may mediate posttranscriptional regulation of HO; involved in propagation of M2 dsRNA satellite of L-A virus; allelic variation affects mitochondrial genome stability, drug resistance, and more; forms cytoplasmic foci upon DNA replication stress	positive regulation of translation|interspecies interaction between organisms|response to DNA damage stimulus	nuclease activity	polysome|cytoplasm
YPL103C	YPL103C	FMP30	hom	Verified	1.02203250507782	0.153382758063666	no	672	0.154903750446034	546	NA	FT	LIPID METABOLISM	MITOCHONDRION		Mitochondrial inner membrane protein with a role in maintaining mitochondrial morphology and normal cardiolipin levels; proposed to be involved in N-acylethanolamine metabolism; related to mammalian N-acylPE-specific phospholipase D	N-acylphosphatidylethanolamine metabolic process|N-acylethanolamine metabolic process	NAPE-specific phospholipase D activity	mitochondrion|integral to mitochondrial inner membrane
YDL202W	YDL202W	MRPL11	hom	Verified	1.01743081994238	0.154474263350237	no	673	0.159381718908168	558	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YMR194W	YMR194W	RPL36A	hom	Verified	1.01504285786226	0.15504269917024	no	674	0.141197585168384	510	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L36A; N-terminally acetylated; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36A has a paralog, RPL36B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YBR285W_p	YBR285W	YBR285W	hom	Uncharacterized	1.01393161416472	0.15530769243445	no	675	0.178020039053141	583	NA					Putative protein of unknown function; YBR285W is not an essential gene	biological_process	molecular_function	cellular_component
YOR041C_d	YOR041C	YOR041C	hom	Dubious	1.01388482180949	0.155318857350534	no	676	0.128175566916916	440	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the uncharacterized gene CUE5; deletion in cyr1 mutant results in loss of stress resistance	Unknown	Unknown	Unknown
YDL231C	YDL231C	BRE4	hom	Verified	1.01220030756911	0.155721144593236	no	677	0.159055270802554	542	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION			Zinc finger protein containing five transmembrane domains; null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect intracellular transport	endocytosis	molecular_function	integral to membrane
YML062C	YML062C	MFT1	hom	Verified	1.01214507607555	0.155734346324982	no	678	0.169784277537796	604	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA LOCALIZATION	NUCLEUS		Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance	mRNA export from nucleus|DNA recombination|transcription elongation from RNA polymerase II promoter	protein complex scaffold|nucleic acid binding	THO complex part of transcription export complex|nucleoplasmic THO complex
YNL089C_d	YNL089C	YNL089C	hom	Dubious	1.01207349822593	0.155751456349579	no	679	0.155067112905335	560	NA					Dubious open reading frame unlikely to encode a functional protein; almost completely overlaps YNL090W/RHO2 which encodes a small GTPase of the Rho/Rac subfamily of Ras-like proteins	Unknown	Unknown	Unknown
YNL246W	YNL246W	VPS75	hom	Verified	1.01172434532461	0.155834935899598	no	680	0.178960190441662	637	NA	FT	PROTEIN LOCALIZATION|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		NAP family histone chaperone; binds to histones and Rtt109p, stimulating histone acetyltransferase activity; possesses nucleosome assembly activity in vitro; proposed role in vacuolar protein sorting and in double-strand break repair; protein abundance increases in response to DNA replication stress	double-strand break repair via nonhomologous end joining|nucleosome assembly|positive regulation of histone acetylation	histone binding|acetyltransferase activator activity	chromatin|nucleus
YMR069W	YMR069W	NAT4	hom	Verified	1.01134378995976	0.155925957109406	no	681	0.178166944358801	593	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS		N alpha-acetyl-transferase, involved in acetylation of the N-terminal residues of histones H4 and H2A	histone acetylation	histone acetyltransferase activity	nucleus|cytoplasm
YDR504C	YDR504C	SPG3	hom	Verified	1.00955058849973	0.15635532647261	no	682	0.131128087441563	455	NA					Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources	biological_process	molecular_function	cellular_component
YGL004C	YGL004C	RPN14	hom	Verified	1.0090076170118	0.156485490593622	no	683	0.170979040566594	529	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS	NUCLEUS		Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p	proteasome regulatory particle assembly|ubiquitin-dependent protein catabolic process	molecular_function	cytosol|nucleus|cytoplasm
YBL098W	YBL098W	BNA4	hom	Verified	1.00809920114628	0.156703420559413	no	684	0.146341304920527	583	NA	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Kynurenine 3-mono oxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; putative therapeutic target for Huntington disease	de novo NAD biosynthetic process from tryptophan	kynurenine 3-monooxygenase activity	mitochondrial outer membrane|mitochondrion
YJL181W_p	YJL181W	YJL181W	hom	Uncharacterized	1.00740151891534	0.156870930855006	no	685	0.116067520948622	418	NA					Putative protein of unknown function; expression is cell-cycle regulated as shown by microarray analysis; potential regulatory target of Mbp1p, which binds to the YJL181W promoter region; YJL181W has a paralog, YJR030C, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YLR287C-A	YLR287C-A	RPS30A	hom	Verified	1.00513418207142	0.157416121314868	no	686	0.158531493297145	568	NA	FT	TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S30, no bacterial homolog; RPS30A has a paralog, RPS30B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic small ribosomal subunit|cytoplasmic stress granule
YKR003W	YKR003W	OSH6	hom	Verified	1.00360130226881	0.15778541331377	no	687	0.137348610086561	546	NA	FT	VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION	ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Member of an oxysterol-binding protein family; overlapping, redundant functions in sterol metabolism and which collectively perform a function essential for viability; GFP-fusion protein localizes to the cell periphery; overexpression extends lifespan by promoting vacuolar fusion	sterol homeostasis|maintenance of cell polarity|endocytosis|sterol transport|exocytosis|sterol metabolic process	phosphatidic acid binding|lipid binding|phosphatidylinositol-3,4-bisphosphate binding|oxysterol binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-5-phosphate binding|phosphatidylinositol-4-phosphate binding	cortical endoplasmic reticulum|extrinsic to membrane|cytoplasm
YMR151W_d	YMR151W	YIM2	hom	Dubious	1.00059842980438	0.15851049476518	no	688	0.151766273283138	515	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1	Unknown	Unknown	Unknown
YBR158W	YBR158W	AMN1	hom	Verified	0.995904226492038	0.159648340782048	no	689	0.170602720400534	612	NA	FT	CELL CYCLE|CELL DIVISION	NUCLEUS		Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)	mitotic cell cycle checkpoint|negative regulation of exit from mitosis	protein binding	nucleus|cellular bud|cytoplasm
YDL036C	YDL036C	PUS9	hom	Verified	0.995312698090745	0.159792101905836	no	690	0.139631038007602	431	NA	FT	RNA PROCESSING	NUCLEUS|MITOCHONDRION		Mitochondrial tRNA:pseudouridine synthase, catalyzes the formation of pseudouridine at position 32 in mitochondrial tRNAs; contains an N-terminal mitochondrial targeting sequence	tRNA pseudouridine synthesis	pseudouridine synthase activity	mitochondrion|nucleus|cytoplasm
YPL186C	YPL186C	UIP4	hom	Verified	0.993714276172207	0.160180995219545	no	691	0.189415074699883	617	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION		Protein that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope	biological_process	molecular_function	mitochondrial outer membrane|nuclear envelope|endoplasmic reticulum
YDR349C	YDR349C	YPS7	hom	Verified	0.988385540603541	0.161481933119892	no	692	0.160591312894062	572	NA	FT	CELL WALL ORG/BIOGENESIS|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative GPI-anchored aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; located in the cytoplasm and endoplasmic reticulum	fungal-type cell wall organization	aspartic-type endopeptidase activity	endoplasmic reticulum|cytoplasm
YDR061W_p	YDR061W	YDR061W	hom	Uncharacterized	0.987186148441404	0.161775695498324	no	693	0.166718047578974	537	NA	FT	NUCLEOTIDE METABOLISM	MITOCHONDRION		Protein with similarity to ATP-binding cassette (ABC) transporter family members; lacks predicted membrane-spanning regions; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance	biological_process	molecular_function	mitochondrion
YGR203W	YGR203W	YCH1	hom	Verified	0.985823174352162	0.162109945814752	no	694	0.160820316682894	549	NA	FT		NUCLEUS		Phosphatase with sequence similarity to Cdc25p, Arr2p and Mih1p; member of the single-domain rhodanese homology superfamily; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	dephosphorylation	phosphatase activity|protein tyrosine phosphatase activity|thiosulfate sulfurtransferase activity	nucleus|cytoplasm
YDR440W	YDR440W	DOT1	hom	Verified	0.984596182008688	0.162411232909892	no	695	0.165041272757491	558	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS		Nucleosomal histone H3-Lys79 methylase; methylation is required for telomeric silencing, meiotic checkpoint control, and DNA damage response	meiotic recombination checkpoint|postreplication repair|recombinational repair|global genome nucleotide-excision repair|nucleotide-excision repair|DNA damage checkpoint|chromatin silencing at telomere|histone H3-K79 methylation	nucleosomal histone binding|histone methyltransferase activity (H3-K79 specific)	nucleus
YJL169W_d	YJL169W	YJL169W	hom	Dubious	0.984100747152018	0.162532989804777	no	696	0.150589006270145	535	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2	Unknown	Unknown	Unknown
YBR048W	YBR048W	RPS11B	hom	Verified	0.98393236391838	0.162574384788612	no	697	0.173122538298975	613	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11B has a paralog, RPS11A, that arose from the whole genome duplication	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal small subunit assembly	structural constituent of ribosome	cytosolic small ribosomal subunit|90S preribosome
YGR263C	YGR263C	SAY1	hom	Verified	0.983388298125945	0.162708183674974	no	698	0.172301068214835	563	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Sterol deacetylase; component of the sterol acetylation/deacetylation cycle along with Atf2p; integral membrane protein with active site in the ER lumen; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum	response to toxin|sterol metabolic process|sterol deacetylation	steryl deacetylase activity	integral to membrane|endoplasmic reticulum|endoplasmic reticulum lumen
YBL103C	YBL103C	RTG3	hom	Verified	0.98318767054574	0.162757540901598	no	699	0.154256543704805	521	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|SIGNALING	NUCLEUS		Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways	mitochondrion degradation|cellular response to oleic acid|mitochondria-nucleus signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription factor import into nucleus	RNA polymerase II transcription factor binding|sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity	nucleus|cytoplasm
YOR315W	YOR315W	SFG1	hom	Verified	0.982373268774462	0.162957995255766	no	700	0.155010551110145	526	NA	FT	CELL CYCLE	NUCLEUS		Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate	mitotic cell cycle|pseudohyphal growth	molecular_function	nucleus|cytoplasm
YBR046C	YBR046C	ZTA1	hom	Verified	0.982172405849072	0.16300745970506	no	701	0.167495183790371	571	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		NADPH-dependent quinone reductase, GFP-tagged protein localizes to the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin	cellular response to oxidative stress	NADPH:quinone reductase activity|AU-rich element binding|2-alkenal reductase [NAD(P)] activity	nucleus|cytoplasm
YEL023C_p	YEL023C	YEL023C	hom	Uncharacterized	0.981915124704078	0.163070831945943	no	702	0.165173864567871	555	NA					Putative protein of unknown function; expression is increased greatly during sporulation; YEL023C is not an essential gene	biological_process	molecular_function	cellular_component
YBR082C	YBR082C	UBC4	hom	Verified	0.981246358694695	0.163235634040497	no	703	0.143751200528361	535	NA	FT	PROTEOLYSIS			Ubiquitin-conjugating enzyme (E2); mediates degradation of abnormal or excess proteins, including calmodulin and histone H3; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response; UBC4 has a paralog, UBC5, that arose from the whole genome duplication	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein monoubiquitination|protein polyubiquitination|protein ubiquitination|response to stress	ubiquitin binding|ubiquitin-protein ligase activity	proteasome complex
YOL013W-B_d	YOL013W-B	YOL013W-B	hom	Dubious	0.978941910569627	0.163804341234041	no	704	0.134685258616661	498	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the long terminal repeat (LTR) of a Ty1 element	Unknown	Unknown	Unknown
YPL096W	YPL096W	PNG1	hom	Verified	0.978282890683302	0.163967214772377	no	705	0.173630448657862	577	NA	FT	RESPONSE TO DNA DAMAGE|PROTEOLYSIS	NUCLEUS|MITOCHONDRION		Conserved peptide N-glycanase required for deglycosylation of misfolded glycoproteins during proteasome-dependent degradation; localizes to the cytoplasm and nucleus; activity is enhanced by interaction with Rad23p	misfolded or incompletely synthesized protein catabolic process|protein deglycosylation	peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity	cytosol|mitochondrion|nucleus
YER046W-A_d	YER046W-A	YER046W-A	hom	Dubious	0.97790732091312	0.164060081990292	no	706	0.152603840745934	549	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR271W_p	YLR271W	YLR271W	hom	Uncharacterized	0.977771896918626	0.164093576678761	no	707	0.144400361588348	489	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	nucleus|cytoplasm
YHR114W	YHR114W	BZZ1	hom	Verified	0.977679177529305	0.164116511709457	no	708	0.137673963972877	503	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		SH3 domain protein implicated in the regulation of actin polymerization, able to recruit actin polymerization machinery through its SH3 domains, colocalizes with cortical actin patches and Las17p, interacts with type I myosins	response to salt stress|actin filament organization|endocytosis	molecular_function	mating projection tip|cytoplasm|actin cortical patch
YGL002W	YGL002W	ERP6	hom	Verified	0.977332476500685	0.164202289958373	no	709	0.175711944353297	555	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication	ER to Golgi vesicle-mediated transport	molecular_function	mitochondrion|integral to membrane
YAL037C-A_p	YAL037C-A	YAL037C-A	hom	Uncharacterized	0.976700688491113	0.164358677110122	no	710	0.166945611828406	574	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YHR198C	YHR198C	AIM18	hom	Verified	0.974810723558982	0.164827078413435	no	711	0.166040438383767	601	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	mitochondrion
YKR073C_d	YKR073C	YKR073C	hom	Dubious	0.973937122100716	0.165043880191013	no	712	0.194181674980805	698	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YIL074C	YIL074C	SER33	hom	Verified	0.9725854194837	0.165379696055286	no	713	0.16325320098523	596	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS			3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER33 has a paralog, SER3, that arose from the whole genome duplication	serine family amino acid biosynthetic process	phosphoglycerate dehydrogenase activity	cytoplasm
YMR284W	YMR284W	YKU70	hom	Verified	0.971190554547243	0.16572669828391	no	714	0.143265735669111	523	NA	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING	ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME		Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair	chromatin assembly or disassembly|chromatin silencing|double-strand break repair via nonhomologous end joining|telomere maintenance|double-strand break repair via break-induced replication|double-strand break repair via homologous recombination|chromatin silencing at silent mating-type cassette	damaged DNA binding|RNA binding	nuclear chromatin|nuclear telomeric heterochromatin|nuclear envelope|Ku70:Ku80 complex
YML027W	YML027W	YOX1	hom	Verified	0.971034125152807	0.165765642747971	no	715	0.151723073386868	516	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE	NUCLEUS|CHROMOSOME		Homeobox transcriptional repressor; binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression is cell cycle-regulated; potential Cdc28p substrate; relocalizes from nucleus to cytoplasm upon DNA replication stress; YOX1 has a paralog, YHP1, that arose from the whole genome duplication	negative regulation of transcription involved in G1 phase of mitotic cell cycle	RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription	nuclear chromatin|nucleus
YKL002W	YKL002W	DID4	hom	Verified	0.970674056291038	0.165855307517191	no	716	0.178427763937059	640	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT			Class E Vps protein of the ESCRT-III complex, required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis	protein retention in Golgi apparatus|intralumenal vesicle formation|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|late endosome to vacuole transport	molecular_function	ESCRT III complex|cytoplasm
YLR443W	YLR443W	ECM7	hom	Verified	0.970341851061416	0.165938061451852	no	717	0.165938774311662	630	NA	FT	ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS			Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency	fungal-type cell wall organization|calcium ion transport	molecular_function	integral to membrane
YIL103W	YIL103W	DPH1	hom	Verified	0.970152817279761	0.165985162594463	no	718	0.167423585282592	594	NA					Protein required, along with Dph2p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph2p and Kti11p	peptidyl-diphthamide biosynthetic process from peptidyl-histidine	molecular_function	cytoplasm
YBR003W	YBR003W	COQ1	hom	Verified	0.970021056238885	0.166017998320134	no	719	0.185736936880483	667	NA	FT	KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis	ubiquinone biosynthetic process	trans-hexaprenyltranstransferase activity	mitochondrion
YKR089C	YKR089C	TGL4	hom	Verified	0.969999230153384	0.166023437930666	no	720	0.165823904470558	565	NA	FT	LIPID METABOLISM|CELL DIVISION			Multifunctional triacylglycerol lipase, steryl ester hydrolase, and Ca2+-independent phospholipase A2; catalyzes acyl-CoA dependent acylation of LPA to PA; required with Tgl3p for timely bud formation; phosphorylated and activated by Cdc28p	phospholipid metabolic process|triglyceride catabolic process|triglyceride mobilization|cell budding	lysophosphatidic acid acyltransferase activity|triglyceride lipase activity|calcium-independent phospholipase A2 activity|sterol esterase activity	lipid particle
YML111W	YML111W	BUL2	hom	Verified	0.969283182943752	0.166201958803821	no	721	0.15253617035446	542	NA	FT			UBIQUITIN LIGASE COMPLEX	Component of the Rsp5p E3-ubiquitin ligase complex; involved in intracellular amino acid permease sorting, functions in heat shock element mediated gene expression, essential for growth in stress conditions; BUL2 has a paralog, BUL1, that arose from the whole genome duplication	protein polyubiquitination|protein monoubiquitination	ubiquitin-ubiquitin ligase activity	ubiquitin ligase complex|cytoplasm
YEL017C-A	YEL017C-A	PMP2	hom	Verified	0.968660751958721	0.16635724050335	no	722	0.18245816024022	620	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog, PMP1, that arose from the whole genome duplication	cation transport	molecular_function	membrane
YDL066W	YDL066W	IDP1	hom	Verified	0.96839594495364	0.166423331938456	no	723	0.251882486775061	882	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes	isocitrate metabolic process|glutamate biosynthetic process	isocitrate dehydrogenase (NADP+) activity	mitochondrial nucleoid|mitochondrion
YMR154C	YMR154C	RIM13	hom	Verified	0.968252049936253	0.166459252855472	no	724	0.173429954434656	649	NA	FF|FT	ION HOMEOSTASIS|PROTEOLYSIS|ION HOMEOSTASIS			Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB	protein processing	cysteine-type endopeptidase activity	cellular_component
YPR159W	YPR159W	KRE6	hom	Verified	0.968144921702694	0.166485998827248	no	725	0.201074971997355	669	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Type II integral membrane protein required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; localizes to the ER, plasma membrane, sites of polarized growth and secretory vesicles; functionally redundant with Skn1p	fungal-type cell wall organization|(1->6)-beta-D-glucan biosynthetic process	glucosidase activity	integral to endoplasmic reticulum membrane|integral to membrane|site of polarized growth|transport vesicle|plasma membrane
YLR070C	YLR070C	XYL2	hom	Verified	0.967378653763736	0.166677388577223	no	726	0.171471941274912	570	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM			Xylitol dehydrogenase, converts xylitol to D-xylulose; expression induced by xylose, even though this pentose sugar is not well utilized by S. cerevisiae; null mutant has cell wall defect	xylulose biosynthetic process	D-xylulose reductase activity	cellular_component
YPR122W	YPR122W	AXL1	hom	Verified	0.966749100119566	0.166834737576186	no	727	0.153956550732908	532	NA	FT	CELL CYCLE|CELL DIVISION|PROTEOLYSIS	SITE OF POLARIZED GROWTH		Haploid specific endoprotease that performs one of two N-terminal cleavages during maturation of a-factor mating pheromone; required for axial budding pattern of haploid cells	peptide pheromone maturation|axial cellular bud site selection	metalloendopeptidase activity	mating projection tip|cellular bud neck
YLR072W_p	YLR072W	YLR072W	hom	Uncharacterized	0.966527710755518	0.16689009382465	no	728	0.170968709703206	582	NA	FT		ENDOMEMBRANE SYSTEM		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YLR072W is not an esssential gene	biological_process	molecular_function	cytoplasm
YGL164C	YGL164C	YRB30	hom	Verified	0.962709806155679	0.167846587108267	no	729	0.16421658878903	574	NA	FT	PROTEIN LOCALIZATION	NUCLEUS		RanGTP-binding protein, inhibits RanGAP1 (Rna1p)-mediated GTP hydrolysis of RanGTP (Gsp1p); shares similarity to proteins in other fungi but not in higher eukaryotes	biological_process	GTPase regulator activity	nucleus|cytoplasm
YJR128W_d	YJR128W	YJR128W	hom	Dubious	0.962584597472864	0.167878015084434	no	730	0.157202299902335	471	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSF2	Unknown	Unknown	Unknown
YIR029W	YIR029W	DAL2	hom	Verified	0.961134228842127	0.168242340594371	no	731	0.156852364332523	539	NA					Allantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation	allantoin catabolic process	allantoicase activity	cellular_component
YOR290C	YOR290C	SNF2	hom	Verified	0.960085900977269	0.168505991863317	no	732	0.254799141454771	896	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS	NUCLEUS	RSC COMPLEX	Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p	cellular alcohol catabolic process|ATP-dependent chromatin remodeling|double-strand break repair|strand invasion|positive regulation of mating type switching|sucrose catabolic process|positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation|nucleosome mobilization|chromatin remodeling|DNA-dependent DNA replication|positive regulation of transcription from RNA polymerase II promoter	histone acetyl-lysine binding|RNA polymerase II activating transcription factor binding|DNA-dependent ATPase activity|nucleosomal DNA binding	SWI/SNF complex|nucleus
YFR022W	YFR022W	ROG3	hom	Verified	0.959883050918355	0.168557038693471	no	733	0.143143185956578	510	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION			Protein that binds the ubiquitin ligase Rsp5p via its 2 PY motifs; mutation suppresses the temperature sensitivity of an mck1 rim11 double mutant; proposed to regulate the endocytosis of plasma membrane proteins; ROG3 has a paralog, ROD1, that arose from the whole genome duplication	ubiquitin-dependent endocytosis	ubiquitin protein ligase binding	cellular_component
YBR224W_d	YBR224W	YBR224W	hom	Dubious	0.959139513865492	0.168744233367855	no	734	0.152648322442981	547	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TDP1	Unknown	Unknown	Unknown
YPL198W	YPL198W	RPL7B	hom	Verified	0.959009898418228	0.168776879333664	no	735	0.175826747060816	623	NA	FT	TRANSLATION	NUCLEUS	RIBOSOME	Ribosomal 60S subunit protein L7B; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7B has a paralog, RPL7A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit|nucleolus|cytoplasm
YGR041W	YGR041W	BUD9	hom	Verified	0.958639467263068	0.168870201409535	no	736	0.137122711805126	454	NA	FT	CELL CYCLE|CELL DIVISION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Protein involved in bud-site selection; mutant has increased aneuploidy tolerance; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the distal pole	cellular bud site selection	molecular_function	plasma membrane|cellular bud neck
YDL001W	YDL001W	RMD1	hom	Verified	0.958183309498725	0.168985165979717	no	737	0.160765158509806	595	NA	FT	CELL CYCLE			Cytoplasmic protein required for sporulation	biological_process	molecular_function	cytoplasm
YER027C	YER027C	GAL83	hom	Verified	0.95484617229939	0.169827746975487	no	738	0.169335023821386	534	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|SIGNALING|PROTEIN PHOSPHORYLATION	ENDOMEMBRANE SYSTEM|NUCLEUS		One of three possible beta-subunits of the Snf1 kinase complex, allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source; contains glycogen-binding domain	signal transduction|cell adhesion|protein phosphorylation|invasive growth in response to glucose limitation|regulation of protein complex assembly	AMP-activated protein kinase activity	AMP-activated protein kinase complex|nucleus|nuclear envelope lumen|cytoplasm
YIL173W	YIL173W	VTH1	hom	Verified	0.954021423425707	0.170036399117174	no	739	0.138741131100087	472	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	GOLGI APPARATUS		Putative membrane glycoprotein with strong similarity to Vth2p and Pep1p/Vps10p, may be involved in vacuolar protein sorting	Golgi to vacuole transport	signal sequence binding	endosome|integral to membrane
YGL101W_p	YGL101W	YGL101W	hom	Uncharacterized	0.953749677935065	0.170105183627344	no	740	0.172443608826467	518	NA	FT		NUCLEUS		Putative protein of unknown function; non-essential gene with similarity to YBR242W; interacts with the DNA helicase Hpr5p	biological_process	molecular_function	nucleus|cytoplasm
YER069W	YER069W	ARG5,6	hom	Verified	0.952655639647691	0.170382288154079	no	741	0.153183401698542	461	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine	ornithine biosynthetic process|arginine biosynthetic process|regulation of transcription, DNA-dependent	N-acetyl-gamma-glutamyl-phosphate reductase activity|acetylglutamate kinase activity	mitochondrion|mitochondrial matrix
YKR034W	YKR034W	DAL80	hom	Verified	0.952010397650125	0.170545854355891	no	742	0.168403098889117	602	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Gzf3p; DAL80 has a paralog, GZF3, that arose from the whole genome duplication	nitrogen catabolite repression of transcription|negative regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity	nucleus
YNL291C	YNL291C	MID1	hom	Verified	0.951180308003572	0.170756426497349	no	743	0.143240249465714	466	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		N-glycosylated integral membrane protein of the ER membrane and plasma membrane, functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone; interacts with Cch1p; forms an oligomer	calcium ion transport	stretch-activated, cation-selective, calcium channel activity|calcium channel activity	endoplasmic reticulum|plasma membrane
YDR092W	YDR092W	UBC13	hom	Verified	0.949962483865065	0.171065657792175	no	744	0.155992885574712	557	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE	NUCLEUS		Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus	postreplication repair|protein monoubiquitination|protein polyubiquitination|free ubiquitin chain polymerization	ubiquitin-protein ligase activity	ubiquitin conjugating enzyme complex|nucleus|cytoplasm
YHR130C_d	YHR130C	YHR130C	hom	Dubious	0.949411442826116	0.171205696390735	no	745	0.177106930231556	600	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YCL057C-A	YCL057C-A	MOS1	hom	Verified	0.948305362585077	0.171487010833651	no	746	0.155723289816189	571	NA	FT	MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial protein essential for proper inner membrane organization; conserved component of the mitochondrial inner membrane organizing system (MICOS, MINOS, or MitOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture; ortholog of human MINOS1	cristae formation	molecular_function	mitochondrion|mitochondrial crista junction|integral to mitochondrial inner membrane
YIR038C	YIR038C	GTT1	hom	Verified	0.947814909435463	0.171611844503988	no	747	0.174209236324952	621	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p	glutathione metabolic process	glutathione transferase activity|glutathione peroxidase activity	mitochondrial outer membrane|mitochondrion|endoplasmic reticulum|plasma membrane
YMR031W-A_d	YMR031W-A	YMR031W-A	hom	Dubious	0.946730613903561	0.171888033222564	no	748	0.170114306517145	564	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C	Unknown	Unknown	Unknown
YPR043W	YPR043W	RPL43A	hom	Verified	0.946238346858322	0.172013515731027	no	749	0.129330639678349	463	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L43A; null mutation confers a dominant lethal phenotype; homologous to mammalian ribosomal protein L37A, no bacterial homolog; RPL43A has a paralog, RPL43B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YDL082W	YDL082W	RPL13A	hom	Verified	0.946108585609135	0.172046602569359	no	750	0.141367603948769	520	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L13A; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13A has a paralog, RPL13B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YOR369C	YOR369C	RPS12	hom	Verified	0.944088167455152	0.172562297697465	no	751	0.167883850878673	594	NA	FT	TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S12, no bacterial homolog	cytoplasmic translation	structural constituent of ribosome	cytosolic small ribosomal subunit
YKR067W	YKR067W	GPT2	hom	Verified	0.943628061516845	0.1726798736065	no	752	0.192147671058422	699	NA	FT	LIPID METABOLISM	ENDOPLASMIC RETICULUM		Glycerol-3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis; the most conserved motifs and functionally relevant residues are oriented towards the ER lumen	phospholipid biosynthetic process	glycerol-3-phosphate O-acyltransferase activity|glycerone-phosphate O-acyltransferase activity	integral to membrane|lipid particle|endoplasmic reticulum|cytoplasm
YGR270W	YGR270W	YTA7	hom	Verified	0.940825353378858	0.173397183005842	no	753	0.222663042558708	751	NA	FT	TRANSCRIPTION FROM RNA POL II|GENE SILENCING	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Protein that localizes to chromatin and has a role in regulation of histone gene expression; has a bromodomain-like region that interacts with the N-terminal tail of histone H3, and an ATPase domain; potentially phosphorylated by Cdc28p	negative regulation of transcription from RNA polymerase II promoter|negative regulation of chromatin silencing|positive regulation of transcription from RNA polymerase II promoter	chromatin binding|histone binding	extrinsic to endoplasmic reticulum membrane|nucleus
YDR071C	YDR071C	PAA1	hom	Verified	0.939070237959647	0.173847341811612	no	754	0.184807295930082	643	NA	FT	CHROMATIN ORGANIZATION			Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication	chromatin organization	diamine N-acetyltransferase activity|aralkylamine N-acetyltransferase activity	cytoplasm
YGR022C_d	YGR022C	YGR022C	hom	Dubious	0.938676351572322	0.173948469346798	no	755	0.138342440637323	480	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W	Unknown	Unknown	Unknown
YER175W-A_p	YER175W-A	YER175W-A	hom	Uncharacterized	0.936181955315365	0.174589756109267	no	756	0.166642777653094	592	NA					Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YKL070W_p	YKL070W	YKL070W	hom	Uncharacterized	0.935434916481036	0.174782104818832	no	757	0.148003133845513	508	NA	FT	OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Putative protein of unknown function; expression induced in cells treated with mycotoxins patulin or citrinin; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YGL244W	YGL244W	RTF1	hom	Verified	0.935028672521569	0.17488676158225	no	758	0.238918135853098	813	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|GENE SILENCING	NUCLEUS|CHROMOSOME	RNA POL II, HOLOENZYME	Subunit of RNAPII-associated chromatin remodeling Paf1 complex; regulates gene expression by directing cotranscriptional histone modification, influences transcription and chromatin structure through several independent functional domains; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay	mRNA 3'-end processing|snoRNA transcription from an RNA polymerase II promoter|regulation of chromatin silencing at telomere|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of histone H3-K4 methylation|regulation of transcription-coupled nucleotide-excision repair|negative regulation of transcription from RNA polymerase II promoter|recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex|global genome nucleotide-excision repair|snoRNA 3'-end processing|Unknown|transcription elongation from RNA polymerase II promoter	RNA binding|RNA polymerase II transcription factor binding transcription factor activity	nucleus|transcriptionally active chromatin|Cdc73/Paf1 complex
YDR251W	YDR251W	PAM1	hom	Verified	0.934000448923715	0.175151830712045	no	759	0.167358935818075	558	NA	FT	OXIDATION-REDUCTION PROCESS	SITE OF POLARIZED GROWTH		Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype	pseudohyphal growth	molecular_function	cellular bud|cellular bud neck
YLR406C-A_p	YLR406C-A	YLR406C-A	hom	Uncharacterized	0.933988005843165	0.175155040014301	no	760	0.178499556901503	606	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YBR176W	YBR176W	ECM31	hom	Verified	0.933587053815014	0.175258472974998	no	761	0.183498201918089	545	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Ketopantoate hydroxymethyltransferase, required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate	pantothenate biosynthetic process	3-methyl-2-oxobutanoate hydroxymethyltransferase activity	mitochondrion
YLR077W	YLR077W	FMP25	hom	Verified	0.933438362281038	0.175296840538298	no	762	0.181589769758534	624	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial inner membrane protein required for an early step in assembly of respiratory complex III (cytochrome bc1 complex); mRNA is targeted to mitochondria	mitochondrial respiratory chain complex III assembly	molecular_function	mitochondrion|integral to mitochondrial inner membrane
YDR019C	YDR019C	GCV1	hom	Verified	0.932461224328084	0.175549108445312	no	763	0.189670696437311	658	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		T subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm	glycine catabolic process|glycine metabolic process|one-carbon metabolic process	glycine dehydrogenase (decarboxylating) activity	mitochondrion|glycine cleavage complex
YKL127W	YKL127W	PGM1	hom	Verified	0.931824290383627	0.175713669615587	no	764	0.142570797145786	497	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism	glucose 6-phosphate metabolic process|galactose catabolic process|glucose 1-phosphate metabolic process|UDP-glucose metabolic process|trehalose biosynthetic process|glycogen biosynthetic process	phosphoglucomutase activity	cytoplasm
YKL135C	YKL135C	APL2	hom	Verified	0.93108186494168	0.175905609360954	no	765	0.21656894045948	699	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS|PLASMA MEMBRANE		Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress	Golgi to vacuole transport|vesicle-mediated transport	clathrin binding	AP-1 adaptor complex
YDR079W	YDR079W	PET100	hom	Verified	0.93087714516494	0.1759585590473	no	766	0.182541879779167	638	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme	mitochondrial respiratory chain complex IV assembly|aerobic respiration	unfolded protein binding	mitochondrion|mitochondrial inner membrane|integral to mitochondrial inner membrane
YGR196C	YGR196C	FYV8	hom	Verified	0.929615902629656	0.176284995341836	no	767	0.176392958537356	618	NA					Protein of unknown function, required for survival upon exposure to K1 killer toxin	biological_process	molecular_function	cytoplasm
YKR033C_d	YKR033C	YKR033C	hom	Dubious	0.928972337700251	0.176451711148436	no	768	0.176599131011606	565	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene DAL80	Unknown	Unknown	Unknown
YLR393W	YLR393W	ATP10	hom	Verified	0.927064877040705	0.176946425395291	no	769	0.172489727942276	575	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, interacts genetically with ATP6	mitochondrial proton-transporting ATP synthase complex assembly	unfolded protein binding	integral to mitochondrial membrane|mitochondrion|mitochondrial inner membrane
YCL023C_d	YCL023C	YCL023C	hom	Dubious	0.926239130977595	0.177160860422948	no	770	0.161115891235502	531	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF KCC4	Unknown	Unknown	Unknown
YOR221C	YOR221C	MCT1	hom	Verified	0.924373082580047	0.17764605212165	no	771	0.21576175816531	758	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Predicted malonyl-CoA:ACP transferase, putative component of a type-II mitochondrial fatty acid synthase that produces intermediates for phospholipid remodeling	fatty acid metabolic process|aerobic respiration	[acyl-carrier-protein] S-malonyltransferase activity	mitochondrion
YIL127C_p	YIL127C	RRT14	hom	Uncharacterized	0.924138871671311	0.177707008526838	no	772	0.166445782781604	585	NA	FT		NUCLEUS		Putative protein of unknown function; identified in a screen for mutants with decreased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis	biological_process	molecular_function	nucleolus
YFL046W_p	YFL046W	FMP32	hom	Uncharacterized	0.923781875751457	0.177799946696775	no	773	0.169317057185298	562	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YIR037W	YIR037W	HYR1	hom	Verified	0.923695026543315	0.177822561133123	no	774	0.185631866544653	654	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS			Thiol peroxidase that functions as a hydroperoxide receptor to sense intracellular hydroperoxide levels and transduce a redox signal to the Yap1p transcription factor	cellular response to oxidative stress	phospholipid-hydroperoxide glutathione peroxidase activity|glutathione peroxidase activity	intracellular
YPL037C	YPL037C	EGD1	hom	Verified	0.922812338657581	0.178052504822146	no	775	0.191135167700444	630	NA	FT	PROTEIN LOCALIZATION	NUCLEUS		Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b	'de novo' cotranslational protein folding	unfolded protein binding	nascent polypeptide-associated complex
YDR293C	YDR293C	SSD1	hom	Verified	0.922150972010236	0.17822491624843	no	776	0.309403995310542	1103	NA	FF|FT	CELL CYCLE|TRANSLATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION|RNA LOCALIZATION	NUCLEUS|SITE OF POLARIZED GROWTH		Translational repressor with a role in polar growth and wall integrity; regulated by Cbk1p phosphorylation to effect bud-specific translational control and localization of specific mRNAs; interacts with TOR pathway components; contains a functional N-terminal nuclear localization sequence and nucleocytoplasmic shuttling appears to be critical to Ssd1p function	regulation of fungal-type cell wall organization|negative regulation of translation|intracellular mRNA localization	mRNA binding|mRNA 5'-UTR binding|translation repressor activity, nucleic acid binding	nucleus|cellular bud|cytoplasmic stress granule|cytoplasmic mRNA processing body|cellular bud neck|cytoplasm
YHR138C	YHR138C	YHR138C	hom	Verified	0.92166043072987	0.178352863213084	no	777	0.176797519798111	569	NA	FT	MEMBRANE ORGANIZATION			Protein of unknown function; similar to Pbi2p; double null mutant lacking Pbi2p and Yhr138cp exhibits highly fragmented vacuoles; protein abundance increases in response to DNA replication stress	vacuole fusion, non-autophagic	endopeptidase inhibitor activity	cellular_component
YDR403W	YDR403W	DIT1	hom	Verified	0.921176635051414	0.178479107406528	no	778	0.163839223253283	521	NA	FT	CELL WALL ORG/BIOGENESIS			Sporulation-specific enzyme required for spore wall maturation, involved in the production of a soluble LL-dityrosine-containing precursor of the spore wall; transcripts accumulate at the time of prospore enclosure	ascospore wall assembly	catalytic activity	cellular_component
YGR255C	YGR255C	COQ6	hom	Verified	0.920573016782757	0.178636697644639	no	779	0.182882292743426	658	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM	MITOCHONDRION		Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)	ubiquinone biosynthetic process	N,N-dimethylaniline monooxygenase activity	mitochondrion|mitochondrial inner membrane
YCL039W	YCL039W	GID7	hom	Verified	0.920089162929282	0.178763083517903	no	780	0.174157516700247	581	NA	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS	NUCLEUS		Subunit of GID Complex that binds directly to central component Vid30p; GID complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; Gid7p contains six WD40 repeats; computational analysis suggests that Gid7p and Moh1p have similar functions	negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process	molecular_function	nucleus|GID complex|cytoplasm
YDR244W	YDR244W	PEX5	hom	Verified	0.919280055297947	0.17897455359798	no	781	0.202105571476644	638	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PEROXISOME ORGANIZATION			Peroxisomal membrane signal receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions	protein import into peroxisome matrix, docking	peroxisome matrix targeting signal-1 binding|protein binding, bridging	cytosol|peroxisomal membrane|peroxisome
YDR003W-A_p	YDR003W-A	YDR003W-A	hom	Uncharacterized	0.918624866930322	0.179145910311818	no	782	0.198261448704436	645	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YGR192C	YGR192C	TDH3	hom	Verified	0.917739772395575	0.179377560062092	no	783	0.185375043593503	635	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Glyceraldehyde-3-phosphate dehydrogenase, isozyme 3; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; TDH3 has a paralog, TDH2, that arose from the whole genome duplication	gluconeogenesis|reactive oxygen species metabolic process|glycolysis|apoptotic process	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity	mitochondrion|fungal-type cell wall|lipid particle|plasma membrane|cytoplasm
YOR201C	YOR201C	MRM1	hom	Verified	0.917621773751004	0.179408457263293	no	784	0.186886862271939	666	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	MITOCHONDRION		Ribose methyltransferase that modifies a functionally critical, conserved nucleotide in mitochondrial 21S rRNA	rRNA modification	rRNA (guanine-N1-)-methyltransferase activity	mitochondrion
YMR090W_p	YMR090W	YMR090W	hom	Uncharacterized	0.917586222650378	0.179417766750721	no	785	0.192603056119323	641	NA					Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; GFP-fusion protein localizes to the cytoplasm; up-regulated in response to the fungicide mancozeb; not essential for viability	biological_process	molecular_function	cytoplasm
YPL031C	YPL031C	PHO85	hom	Verified	0.915063979770843	0.180079021651784	no	786	0.218744181473793	716	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES A	NUCLEUS		Cyclin-dependent kinase, with ten cyclin partners; involved in regulating the cellular response to nutrient levels and environmental conditions and progression through the cell cycle	regulation of transcription involved in G1/S phase of mitotic cell cycle|negative regulation of calcium-mediated signaling|regulation of protein stability|regulation of protein localization|protein phosphorylation|response to DNA damage stimulus|negative regulation of phosphate metabolic process|fungal-type cell wall organization|regulation of establishment or maintenance of cell polarity|negative regulation of glycogen biosynthetic process|negative regulation of transcription from RNA polymerase II promoter|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of macroautophagy|negative regulation of macroautophagy	protein kinase activity|cyclin-dependent protein kinase activity	cyclin-dependent protein kinase holoenzyme complex|nucleus
YCR021C	YCR021C	HSP30	hom	Verified	0.915037526738335	0.180085964925141	no	787	0.155372123728125	499	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	PLASMA MEMBRANE		Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase	negative regulation of ATPase activity|response to stress	molecular_function	integral to membrane|plasma membrane
YLR138W	YLR138W	NHA1	hom	Verified	0.913872200511929	0.180392001297312	no	788	0.165665856323076	576	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Na+/H+ antiporter involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH	cellular potassium ion homeostasis|cellular monovalent inorganic cation homeostasis|response to osmotic stress	cation:cation antiporter activity|sodium:hydrogen antiporter activity	membrane raft|integral to membrane|plasma membrane
YAL005C	YAL005C	SSA1	hom	Verified	0.912350974227115	0.180791994326601	no	789	0.145442119456886	512	NA	FT	PROTEIN LOCALIZATION|TRANSLATION|MITOCHONDRION ORGANIZATION	NUCLEUS		ATPase involved in protein folding and NLS-directed nuclear transport; member of HSP70 family; forms chaperone complex with Ydj1p; localized to nucleus, cytoplasm, and cell wall; 98% identical with paralog Ssa2p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes; general targeting factor of Hsp104p to prion fibrils	cytoplasmic translation|protein folding|protein refolding|protein targeting to mitochondrion|SRP-dependent cotranslational protein targeting to membrane, translocation|protein import into nucleus, translocation|response to stress	unfolded protein binding|ATPase activity	fungal-type vacuole membrane|fungal-type cell wall|plasma membrane|nucleus|polysome|chaperonin-containing T-complex|cytoplasm
YFR057W_p	YFR057W	YFR057W	hom	Uncharacterized	0.911083944971171	0.181125572540806	no	790	0.195201682480349	624	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YML090W_d	YML090W	YML090W	hom	Dubious	0.91078529935031	0.181204254837169	no	791	0.175098552231982	589	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source	Unknown	Unknown	Unknown
YLR390W	YLR390W	ECM19	hom	Verified	0.91068720339778	0.181230104235209	no	792	0.210314754246269	729	NA	FT	CELL WALL ORG/BIOGENESIS	MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	fungal-type cell wall organization	molecular_function	mitochondrion
YLR014C	YLR014C	PPR1	hom	Verified	0.91049593412276	0.181280512503552	no	793	0.216861813334008	718	NA	FT	TRANSCRIPTION FROM RNA POL II|NUCLEOTIDE METABOLISM	NUCLEUS		Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of URA1, URA3, URA4, and URA10, which are involved in de novo pyrimidine biosynthesis, in response to pyrimidine starvation; activity may be modulated by interaction with Tup1p	positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding RNA polymerase II transcription factor activity|sequence-specific DNA binding|zinc ion binding	nucleus
YER103W	YER103W	SSA4	hom	Verified	0.910249795938154	0.181345394176447	no	794	0.164838936469107	596	NA	FT	PROTEIN LOCALIZATION	NUCLEUS		Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation; SSA4 has a paralog, SSA3, that arose from the whole genome duplication	protein folding|SRP-dependent cotranslational protein targeting to membrane, translocation|response to stress	unfolded protein binding|ATPase activity	nucleus|cytoplasm
YIL028W_d	YIL028W	YIL028W	hom	Dubious	0.909639727277831	0.181506270072904	no	795	0.192599059844746	605	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOL162W_p	YOL162W	YOL162W	hom	Uncharacterized	0.908876143788721	0.18170775386363	no	796	0.159859559693802	545	NA					Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family	transmembrane transport	transmembrane transporter activity	integral to membrane|membrane
YIL163C_p	YIL163C	YIL163C	hom	Uncharacterized	0.90795177537058	0.18195185050369	no	797	0.167956869826918	602	NA					Protein of unknown function; mRNA identified as translated by ribosome profiling data	biological_process	molecular_function	cellular_component
YDR400W	YDR400W	URH1	hom	Verified	0.907778951006801	0.181997510727751	no	798	0.167891853513026	561	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	NUCLEUS		Uridine nucleosidase (uridine-cytidine N-ribohydrolase), cleaves N-glycosidic bonds in nucleosides; involved in the pyrimidine salvage and nicotinamide riboside salvage pathways	pyrimidine-containing compound salvage|NAD biosynthesis via nicotinamide riboside salvage pathway|pyrimidine nucleoside catabolic process|nicotinate nucleotide salvage	ribosylpyrimidine nucleosidase activity|nicotinic acid riboside hydrolase activity|nicotinamide riboside hydrolase activity|uridine nucleosidase activity	nucleus|cytoplasm
YOR008C	YOR008C	SLG1	hom	Verified	0.907326348704492	0.182117122274215	no	799	0.252600182181071	891	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|PEROXISOME ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON		Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway; involved in maintenance of cell wall integrity; required for mitophagy; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response	positive regulation of endocytosis|Rho protein signal transduction|actin cytoskeleton organization|fungal-type cell wall organization|response to heat|peroxisome degradation|establishment of cell polarity|response to osmotic stress	transmembrane signaling receptor activity	plasma membrane|mating projection tip|cellular bud neck
YDL107W	YDL107W	MSS2	hom	Verified	0.905050358237224	0.182719354645163	no	800	0.184806949592226	654	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Peripherally bound inner membrane protein of the mitochondrial matrix involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p	protein insertion into mitochondrial membrane from inner side	molecular_function	extrinsic to mitochondrial inner membrane|mitochondrial matrix
YMR004W	YMR004W	MVP1	hom	Verified	0.903924506678603	0.183017716691222	no	801	0.200247491136128	669	NA	FT	PROTEIN LOCALIZATION|VACUOLAR TRANSPORT	NUCLEUS		Protein required for sorting proteins to the vacuole; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions; protein abundance increases in response to DNA replication stress	protein targeting to vacuole	phosphatidylinositol-3-phosphate binding	nucleus|cytoplasm
YHR003C	YHR003C	YHR003C	hom	Verified	0.903702060751074	0.183076703054732	no	802	0.137274504347886	442	NA	FT		MITOCHONDRION		Protein of unknown function, localized to the mitochondrial outer membrane	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion
YML002W_p	YML002W	YML002W	hom	Uncharacterized	0.903485912626103	0.183134030779323	no	803	0.158802790145424	537	NA					Putative protein of unknown function; expression induced by heat and by calcium shortage	biological_process	molecular_function	cellular_component
YKR070W_p	YKR070W	YKR070W	hom	Uncharacterized	0.903457948266619	0.183141448423616	no	804	0.179258929015607	594	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YOR185C	YOR185C	GSP2	hom	Verified	0.902735672852741	0.183333099434028	no	805	0.202208280901479	678	NA	FT	PROTEIN LOCALIZATION|SIGNALING|NUCLEOTIDE METABOLISM	NUCLEUS		GTP binding protein (mammalian Ranp homolog); involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas); Gsp1p homolog that is not required for viability; protein abundance increases in response to DNA replication stress	nucleus organization	GTPase activity	integral to membrane|nucleus
YBL022C	YBL022C	PIM1	hom	Verified	0.901575654609274	0.183641164202053	no	806	0.230566122808406	787	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria	chaperone-mediated protein complex assembly|misfolded or incompletely synthesized protein catabolic process	ATP-dependent peptidase activity	mitochondrion|mitochondrial matrix
YLL020C_d	YLL020C	YLL020C	hom	Dubious	0.900810889634673	0.183844438313163	no	807	0.162464682323439	541	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KNS1	Unknown	Unknown	Unknown
YNL123W	YNL123W	NMA111	hom	Verified	0.897771205961142	0.184653769274787	no	808	0.2226091865559	786	NA	FT	LIPID METABOLISM|PROTEOLYSIS	NUCLEUS		Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases	apoptotic process|cellular lipid metabolic process|protein catabolic process|cellular response to heat	serine-type peptidase activity	nucleus
YNL047C	YNL047C	SLM2	hom	Verified	0.897372350989419	0.184760130574705	no	809	0.156423509003814	536	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|SIGNALING|CYTOSKELETON ORGANIZATION	PLASMA MEMBRANE		Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; SLM2 has a paralog, SLM1, that arose from the whole genome duplication	eisosome assembly|TOR signaling cascade|regulation of cell growth|actin filament bundle assembly|endosomal transport|establishment or maintenance of actin cytoskeleton polarity|actin cytoskeleton organization	phosphatidylinositol binding	plasma membrane
YML076C	YML076C	WAR1	hom	Verified	0.896577078496948	0.184972316830908	no	810	0.159363962726644	539	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS|MITOCHONDRION		Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively	response to acid	sequence-specific DNA binding transcription factor activity	mitochondrion|nucleus
YLR319C	YLR319C	BUD6	hom	Verified	0.895264821214968	0.18532277043525	no	811	0.198543743463205	611	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Actin- and formin-interacting protein; stimulates actin cable nucleation by recruiting actin monomers to Bni1p; involved in polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate	bipolar cellular bud site selection|positive regulation of formin-nucleated actin cable assembly|cellular bud site selection|Rho protein signal transduction|extrachromosomal circular DNA localization involved in cell aging|establishment of cell polarity|response to osmotic stress|cytokinesis	cytoskeletal regulatory protein binding	polarisome|actin cap|spindle pole body|mating projection tip
YPL161C	YPL161C	BEM4	hom	Verified	0.894675534687061	0.185480280314959	no	812	0.278596472489674	952	NA	FF|FT	SIGNALING|CYTOSKELETON ORGANIZATION	NUCLEUS		Protein involved in establishment of cell polarity and bud emergence; interacts with the Rho1p small GTP-binding protein and with the Rho-type GTPase Cdc42p; involved in maintenance of proper telomere length	establishment of cell polarity|Rho protein signal transduction|actin cytoskeleton organization	molecular_function	nucleus|cytoplasm
YOR356W	YOR356W	CIR2	hom	Verified	0.894056425800685	0.185645850862714	no	813	0.181061177614569	626	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Putative ortholog of human electron transfer flavoprotein dehydrogenase (ETF-dH); found in a large supramolecular complex with other mitochondrial dehydrogenases; may have a role in oxidative stress response	biological_process	molecular_function	mitochondrion
YDR220C_d	YDR220C	YDR220C	hom	Dubious	0.893027046838998	0.185921344350408	no	814	0.164902394131163	576	NA					Dubious open reading frame, null mutant exhibits synthetic phenotype with alpha-synuclein	Unknown	Unknown	Unknown
YPL274W	YPL274W	SAM3	hom	Verified	0.892341479939385	0.186104963716503	no	815	0.221757354220792	683	NA	FT		ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p	spermidine transport|putrescine transport|S-adenosylmethionine transport	S-adenosylmethionine transmembrane transporter activity|spermidine transmembrane transporter activity|putrescine transmembrane transporter activity	integral to membrane|plasma membrane
YOL150C_d	YOL150C	YOL150C	hom	Dubious	0.891625008847827	0.186296980408934	no	816	0.173768104501045	582	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YCR102W-A_d	YCR102W-A	YCR102W-A	hom	Dubious	0.890557448991611	0.186583317707867	no	817	0.155125969105683	503	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YHL011C	YHL011C	PRS3	hom	Verified	0.889391196864687	0.186896437200462	no	818	0.206661798490471	749	NA	FF|FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM			5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes	fungal-type cell wall organization|5-phosphoribose 1-diphosphate biosynthetic process|regulation of cell size	ribose phosphate diphosphokinase activity	cytoplasm
YGR151C_d	YGR151C	YGR151C	hom	Dubious	0.888982138249215	0.187006339684113	no	819	0.18571125617353	647	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF RSR1/BUD1/YGR152C; relative distribution to the nucleus increases upon DNA replication stress	Unknown	Unknown	Unknown
YIR043C	YIR043C	YIR043C	hom	pseudogene	0.887706835284448	0.187349234087428	no	820	0.188362083565731	619	NA					Possible pseudogene in strain S288C; YIR043C and the adjacent ORF, YIR044C, together may encode a non-functional member of the conserved, often subtelomerically-encoded Cos protein family	biological_process	molecular_function	cellular_component
YCR084C	YCR084C	TUP1	hom	Verified	0.887450613668676	0.18741817199621	no	821	0.179824328890075	638	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		General repressor of transcription, forms complex with Cyc8p, involved in the establishment of repressive chromatin structure through interactions with histones H3 and H4, appears to enhance expression of some genes	nucleosome positioning|regulation of transcription from RNA polymerase II promoter in response to osmotic stress|histone exchange|negative regulation of mating-type specific transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter by glucose|negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter in response to hypoxia|negative regulation of transcription from RNA polymerase II promoter during mitosis|Unknown	ubiquitin binding|histone deacetylase binding|histone binding|phosphatidylinositol-3,5-bisphosphate binding|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription|mediator complex binding	nucleus|transcriptional repressor complex
YHR060W	YHR060W	VMA22	hom	Verified	0.886493702012245	0.187675773215742	no	822	0.191231254515312	633	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Peripheral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)	vacuolar proton-transporting V-type ATPase complex assembly|vacuolar acidification	unfolded protein binding	extrinsic to endoplasmic reticulum membrane
YDL090C	YDL090C	RAM1	hom	Verified	0.886027506882254	0.187801352438409	no	823	0.254603437766863	884	NA	FF|FT	PROTEIN PRENYLATION			Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit	protein farnesylation	protein farnesyltransferase activity	protein farnesyltransferase complex
YCR020C	YCR020C	PET18	hom	Verified	0.885958087734123	0.187820056348307	no	824	0.18611802126889	635	NA					Protein of unknown function, has weak similarity to proteins involved in thiamin metabolism; expression is induced in the absence of thiamin	thiamine metabolic process	molecular_function	cytosol
YOR208W	YOR208W	PTP2	hom	Verified	0.883334286204179	0.18852784212819	no	825	0.176524584033708	617	NA	FT	PROTEIN LOCALIZATION|SIGNALING|PROTEIN PHOSPHORYLATION	NUCLEUS		Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the nucleus	inactivation of MAPK activity involved in osmosensory signaling pathway|inactivation of MAPK activity involved in cell wall biogenesis|regulation of sporulation|regulation of protein localization|protein dephosphorylation	protein tyrosine phosphatase activity	nucleus
YMR150C	YMR150C	IMP1	hom	Verified	0.882732909231235	0.18869029846626	no	826	0.172698430618702	522	NA	FT	PROTEIN LOCALIZATION|PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p	protein processing involved in protein targeting to mitochondrion	endopeptidase activity	mitochondrion|mitochondrial inner membrane peptidase complex
YLR429W	YLR429W	CRN1	hom	Verified	0.88192635834276	0.188908316037805	no	827	0.169629184140532	594	NA	FT	CYTOSKELETON ORGANIZATION	CYTOSKELETON		Coronin, cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity; plays a role in regulation of actin patch assembly	microtubule-based process|actin filament organization|actin cortical patch localization|Unknown|negative regulation of Arp2/3 complex-mediated actin nucleation	microtubule binding|actin filament binding|protein binding, bridging	Arp2/3 protein complex|actin cortical patch
YOR118W	YOR118W	RTC5	hom	Verified	0.881460006074333	0.18903444581068	no	828	0.214816372150766	726	NA					Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity	biological_process	molecular_function	cytoplasm
YGR295C	YGR295C	COS6	hom	Verified	0.881120340830806	0.189126344414379	no	829	0.163905535575749	517	NA					Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YFL040W_p	YFL040W	YFL040W	hom	Uncharacterized	0.88066641772918	0.189249199156124	no	830	0.177728201868296	552	NA					Putative transporter, member of the sugar porter family; YFL040W is not an essential gene	transmembrane transport	substrate-specific transmembrane transporter activity	integral to membrane|membrane
YJL201W	YJL201W	ECM25	hom	Verified	0.877634778234906	0.19007097472914	no	831	0.195560315539309	682	NA	FT	SIGNALING|CELL WALL ORG/BIOGENESIS			Non-essential protein of unknown function; promoter contains a consensus binding sequence for factor Abf1p	fungal-type cell wall organization|filamentous growth	molecular_function	cytoplasm
YMR031C	YMR031C	EIS1	hom	Verified	0.877092176222506	0.19021828694287	no	832	0.201059384264405	652	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS	MITOCHONDRION|PLASMA MEMBRANE		Component of the eisosome required for proper eisosome assembly; similarity to Ykl050cp and Uso1p; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress	eisosome assembly	molecular_function	eisosome|mitochondrion|membrane raft|cytoplasm
YKL136W_d	YKL136W	YKL136W	hom	Dubious	0.875922486755736	0.190536087015313	no	833	0.217325002054299	720	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF APL2/YKL135C	Unknown	Unknown	Unknown
YML016C	YML016C	PPZ1	hom	Verified	0.875762911018272	0.190579468377341	no	834	0.210825593613186	694	NA	FT	PROTEIN LOCALIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS	NUCLEUS|PLASMA MEMBRANE		Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance	cellular sodium ion homeostasis|cellular protein localization|protein dephosphorylation	protein serine/threonine phosphatase activity	extrinsic to plasma membrane|nucleus|cytoplasm
YLR054C	YLR054C	OSW2	hom	Verified	0.874530003022816	0.190914844170349	no	835	0.196633097327342	659	NA	FT	CELL WALL ORG/BIOGENESIS			Protein of unknown function proposed to be involved in the assembly of the spore wall	ascospore wall assembly	molecular_function	integral to membrane|prospore membrane|cytoplasm
YDR315C	YDR315C	IPK1	hom	Verified	0.874236607985554	0.190994706824367	no	836	0.24346723670729	794	NA	FT		NUCLEUS		Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable	nuclear-transcribed mRNA catabolic process, non-stop decay|inositol phosphate biosynthetic process	inositol pentakisphosphate 2-kinase activity	nucleus
YNR013C	YNR013C	PHO91	hom	Verified	0.87391216252269	0.191083045313854	no	837	0.205845805289306	675	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth	phosphate ion transport|polyphosphate metabolic process	phosphate ion transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|membrane
YKL080W	YKL080W	VMA5	hom	Verified	0.87281740971904	0.191381304331826	no	838	0.256145245069729	857	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane	vacuolar acidification	proton-transporting ATPase activity, rotational mechanism	fungal-type vacuole membrane|vacuolar proton-transporting V-type ATPase, V1 domain|integral to membrane
YLR313C	YLR313C	SPH1	hom	Verified	0.872541698523341	0.191456465189773	no	839	0.212534307422625	741	NA	FT	CELL CYCLE|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein involved in shmoo formation and bipolar bud site selection; homologous to Spa2p, localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p	bipolar cellular bud site selection|pseudohyphal growth|invasive filamentous growth|mating projection assembly	molecular_function	incipient cellular bud site|cellular bud neck|cellular bud tip|mating projection
YDR147W	YDR147W	EKI1	hom	Verified	0.871865063932231	0.191640997297334	no	840	0.189574361635798	624	NA	FT	LIPID METABOLISM			Ethanolamine kinase; primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; exhibits some choline kinase activity, thus contributing to phosphatidylcholine synthesis via the CDP-choline pathway; EKI1 has a paralog, CKI1, that arose from the whole genome duplication	phosphatidylethanolamine biosynthetic process|phosphatidylcholine biosynthetic process	ethanolamine kinase activity|choline kinase activity	cytoplasm
YDR405W	YDR405W	MRP20	hom	Verified	0.870620992135358	0.191980565300382	no	841	0.181011108472785	639	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YGR056W	YGR056W	RSC1	hom	Verified	0.870332164699725	0.192059453064142	no	842	0.264157933147298	932	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS	RSC COMPLEX	Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook	double-strand break repair|ATP-dependent chromatin remodeling|regulation of sporulation resulting in formation of a cellular spore|double-strand break repair via nonhomologous end joining|nucleosome disassembly|transcription elongation from RNA polymerase II promoter	DNA-dependent ATPase activity	RSC complex
YGL144C	YGL144C	ROG1	hom	Verified	0.868554821571855	0.19254533727401	no	843	0.200901054791604	641	NA	FT	LIPID METABOLISM			Protein with putative serine active lipase domain; ROG1 has a paralog, YDL109C, that arose from the whole genome duplication	cellular lipid metabolic process	lipase activity	cellular_component
YKL190W	YKL190W	CNB1	hom	Verified	0.868185211176789	0.192646474441282	no	844	0.196587605985254	686	NA	FF|FT	SIGNALING|ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS			Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1; protein abundance increases in response to DNA replication stress	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|fungal-type cell wall organization|cellular ion homeostasis	calcium-dependent protein serine/threonine phosphatase activity|calcium ion binding	calcineurin complex
YGR222W	YGR222W	PET54	hom	Verified	0.867386001330714	0.192865274661753	no	845	0.20371297147515	686	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial inner membrane protein; binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing	Group I intron splicing|positive regulation of mitochondrial translation|mitochondrial respiratory chain complex IV biogenesis	translation regulator activity|RNA binding	mitochondrion|extrinsic to mitochondrial inner membrane|mitochondrial inner membrane|mitochondrial matrix
YGR049W	YGR049W	SCM4	hom	Verified	0.866983319665623	0.192975574579915	no	846	0.201674909269546	640	NA	FT		MITOCHONDRION		Mitochondrial outer membrane protein of unknown function; predicted to have 4 transmembrane segments; import is mediated by Tom70p and Mim1p; interacts genetically with a cdc4 mutation	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion|integral to membrane
YOR346W	YOR346W	REV1	hom	Verified	0.866555676567286	0.193092753939489	no	847	0.169432744935598	549	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|MITOCHONDRION|CHROMOSOME		Deoxycytidyl transferase; involved in repair of abasic sites and adducted guanines in damaged DNA by translesion synthesis (TLS); forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; relocalizes from nucleus to cytoplasm upon DNA replication stress	error-prone translesion synthesis|error-free translesion synthesis	deoxycytidyl transferase activity|DNA-directed DNA polymerase activity	nuclear chromatin|mitochondrion|replication fork
YPR089W_p	YPR089W	YPR089W	hom	Uncharacterized	0.865904541514794	0.193271256194825	no	848	0.199134443982096	712	NA	FT		GOLGI APPARATUS		Protein of unknown function; exhibits genetic interaction with ERG11 and protein-protein interaction with Hsp82p	biological_process	molecular_function	cellular_component
YKL110C	YKL110C	KTI12	hom	Verified	0.865468604540835	0.19339082028191	no	849	0.211406584539513	742	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p	regulation of transcription from RNA polymerase II promoter|cell growth|tRNA wobble uridine modification	chromatin binding	nucleus|cytoplasm
YKL166C	YKL166C	TPK3	hom	Verified	0.864969146770812	0.193527861626112	no	850	0.163560482214418	547	NA	FT	SIGNALING|MITOCHONDRION ORGANIZATION|PROTEIN PHOSPHORYLATION	NUCLEUS		cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication	protein phosphorylation|mitochondrion organization|Ras protein signal transduction	cAMP-dependent protein kinase activity|protein kinase activity	cAMP-dependent protein kinase complex|nucleus|cytoplasm
YLR053C_p	YLR053C	YLR053C	hom	Uncharacterized	0.864934559551429	0.193537353868218	no	851	0.167347833712976	577	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YKL138C	YKL138C	MRPL31	hom	Verified	0.86475462729804	0.193586739710569	no	852	0.212590288425746	734	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrial large ribosomal subunit
YPR008W	YPR008W	HAA1	hom	Verified	0.864532111284619	0.193647824107104	no	853	0.18188805870751	621	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Transcriptional activator involved in adaptation to weak acid stress; activates transcription of TPO2, YRO2, and other genes encoding membrane stress proteins; HAA1 has a paralog, CUP2, that arose from the whole genome duplication; relocalizes from cytoplasm to nucleus upon DNA replication stress	response to acid|positive regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding RNA polymerase II transcription factor activity	nucleus
YMR052W	YMR052W	FAR3	hom	Verified	0.864317212668175	0.193706828555268	no	854	0.211815802062772	747	NA	FT	CELL CYCLE|SIGNALING	ENDOPLASMIC RETICULUM		Protein of unknown function; involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress	re-entry into mitotic cell cycle after pheromone arrest	molecular_function	endoplasmic reticulum
YJL066C	YJL066C	MPM1	hom	Verified	0.863599932485794	0.193903850632272	no	855	0.208710180652252	713	NA	FT		MITOCHONDRION		Mitochondrial intermembrane space protein of unknown function	biological_process	molecular_function	mitochondrion|extrinsic to membrane
YKL156W	YKL156W	RPS27A	hom	Verified	0.863107533614052	0.194039173120706	no	856	0.206356931296296	693	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27A has a paralog, RPS27B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	cytoplasmic translation|ribosomal small subunit assembly|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit|cytoplasm
YDL137W	YDL137W	ARF2	hom	Verified	0.863079392336596	0.194046908726125	no	857	0.200381637483481	675	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|RESPONSE TO NUTRIENT LEVELS	GOLGI APPARATUS		ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; ARF2 has a paralog, ARF1, that arose from the whole genome duplication	ER to Golgi vesicle-mediated transport|macroautophagy|intra-Golgi vesicle-mediated transport	GTPase activity	cytosol|Golgi-associated vesicle
YGR097W	YGR097W	ASK10	hom	Verified	0.86148943653755	0.194484268321563	no	858	0.196809194604153	652	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO OXIDATIVE STRESS	NUCLEUS	RNA POL II, HOLOENZYME	Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication	cellular protein catabolic process|cellular response to oxidative stress|positive regulation of transcription from RNA polymerase II promoter|positive regulation of glycerol transport	molecular_function	DNA-directed RNA polymerase II, holoenzyme|cytoplasm
YDR213W	YDR213W	UPC2	hom	Verified	0.859986933743062	0.194898122570876	no	859	0.204878859582566	713	NA	FT	TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM	NUCLEUS		Sterol regulatory element binding protein; induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; relocates from intracellular membranes to perinuclear foci on sterol depletion; UPC2 has a paralog, ECM22, that arose from the whole genome duplication	cellular response to hypoxia|positive regulation of ergosterol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|membrane|cytoplasm|perinuclear region of cytoplasm
YML078W	YML078W	CPR3	hom	Verified	0.859128305737128	0.19513486614303	no	860	0.203990858467784	708	NA	FT		MITOCHONDRION		Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; involved in protein refolding after import into mitochondria	protein folding|apoptotic process	peptidyl-prolyl cis-trans isomerase activity	mitochondrion
YDR264C	YDR264C	AKR1	hom	Verified	0.858988459285882	0.1951734415851	no	861	0.317573709075388	1089	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats; AKR1 has a paralog, AKR2, that arose from the whole genome duplication	protein targeting to membrane|regulation of endocytosis|regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion|protein palmitoylation	palmitoyltransferase activity	integral to membrane|Golgi apparatus|membrane
YDR241W_d	YDR241W	BUD26	hom	Dubious	0.858757615269099	0.195237128062195	no	862	0.207007056938878	704	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 1% of ORF overlaps the verified gene SNU56; diploid mutant displays a weak budding pattern phenotype in a systematic assay	Unknown	Unknown	Unknown
YKL068W	YKL068W	NUP100	hom	Verified	0.857910545949922	0.195470930223697	no	863	0.181200351289476	646	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; homologous to Nup116p	positive regulation of transcription, DNA-dependent|mRNA export from nucleus|NLS-bearing substrate import into nucleus|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|protein import into nucleus|protein targeting to nuclear inner membrane|mRNA export from nucleus in response to heat stress	nucleocytoplasmic transporter activity|structural constituent of nuclear pore	nuclear pore central transport channel|integral to membrane|nuclear pore
YIL168W	YIL168W	YIL168W	hom	pseudogene	0.856100187122761	0.195971182579677	no	864	0.196790991844692	642	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Open reading frame, unlikely to produce a functional protein in S288C; in closely related species and other <i>S. cerevisiae</i> strain backgrounds YIL168W and adjacent ORF, YIL167W, constitute a single ORF encoding L-serine dehydratase	serine family amino acid metabolic process	L-serine ammonia-lyase activity	cellular_component
YDR095C_d	YDR095C	YDR095C	hom	Dubious	0.854639857543145	0.196375277553514	no	865	0.200976917343493	630	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YIL047C	YIL047C	SYG1	hom	Verified	0.854276071455444	0.196476021113949	no	866	0.193437396706297	701	NA	FT	SIGNALING	MITOCHONDRION|PLASMA MEMBRANE		Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency	signal transduction	molecular_function	mitochondrion|integral to membrane|plasma membrane
YMR019W	YMR019W	STB4	hom	Verified	0.854183836882342	0.196501568681256	no	867	0.181737639130349	563	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Putative transcription factor; contains a Zn(II)2Cys6 zinc finger domain characteristic of DNA-binding proteins; computational analysis suggests a role in regulation of expression of genes encoding transporters; binds Sin3p in a two-hybrid assay;	biological_process	sequence-specific DNA binding|DNA binding	nucleus
YOR092W	YOR092W	ECM3	hom	Verified	0.853573248807907	0.196670743012461	no	868	0.189879025142473	600	NA	FT	CELL WALL ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from ER to cytoplasm upon DNA replication stress; ECM3 has a paralog, YNL095C, that arose from the whole genome duplication	fungal-type cell wall organization	ATPase activity	integral to membrane|endoplasmic reticulum
YFL010C	YFL010C	WWM1	hom	Verified	0.852699057538082	0.196913106837424	no	869	0.192118508970174	649	NA	FT		NUCLEUS|MITOCHONDRION		WW domain containing protein of unknown function; binds to Mca1p, a caspase-related protease that regulates H2O2-induced apoptosis; overexpression causes G1 phase growth arrest and clonal death that is suppressed by overexpression of MCA1	biological_process	molecular_function	mitochondrion|nucleus|cytoplasm
YJR095W	YJR095W	SFC1	hom	Verified	0.851996381856583	0.197108050107569	no	870	0.186736544617739	602	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization	succinate transport|fumarate transport	succinate:fumarate antiporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YDR127W	YDR127W	ARO1	hom	Verified	0.85087930059205	0.197418202201477	no	871	0.314393204170243	1087	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS			Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids	aromatic amino acid family biosynthetic process	shikimate kinase activity|shikimate 3-dehydrogenase (NADP+) activity|3-phosphoshikimate 1-carboxyvinyltransferase activity|3-dehydroquinate dehydratase activity|3-dehydroquinate synthase activity	cytoplasm
YER079W_p	YER079W	YER079W	hom	Uncharacterized	0.850538953649893	0.197512756472995	no	872	0.187518866910871	619	NA	FT		NUCLEUS		Putative protein of unknown function	biological_process	molecular_function	nucleus|cytoplasm
YGR052W_p	YGR052W	FMP48	hom	Uncharacterized	0.849492412138822	0.197803675313954	no	873	0.235033862968215	794	NA	FT	PROTEIN PHOSPHORYLATION	MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation	protein phosphorylation	protein kinase activity	mitochondrion
YOR072W_d	YOR072W	YOR072W	hom	Dubious	0.848817611150929	0.197991394500814	no	874	0.261268610753476	932	NA	FF				Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive	Unknown	Unknown	Unknown
YPR114W_p	YPR114W	YPR114W	hom	Uncharacterized	0.848598044558737	0.198052497719605	no	875	0.207048468304504	721	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative protein of unknown function	biological_process	molecular_function	integral to membrane|endoplasmic reticulum
YKL031W_d	YKL031W	YKL031W	hom	Dubious	0.847797067221502	0.19827549834278	no	876	0.204048546817501	645	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species	Unknown	Unknown	Unknown
YOR162C	YOR162C	YRR1	hom	Verified	0.84718432643962	0.198446194172703	no	877	0.257939660263737	904	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication	regulation of transcription from RNA polymerase II promoter in response to oxidative stress|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity	nucleus
YBR137W	YBR137W	YBR137W	hom	Verified	0.845318569268542	0.198966497991911	no	878	0.172177206170885	608	NA					Protein of unknown function; localized to the cytoplasm; binds to Replication Protein A (RPA); also interacts with Sgt2p; YBR137W is not an essential gene	biological_process	molecular_function	TRC complex|cytoplasm
YAL024C	YAL024C	LTE1	hom	Verified	0.843945785478553	0.199349850751056	no	879	0.252469554292307	898	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|SIGNALING|CELL DIVISION			Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures	regulation of exit from mitosis|mitotic cell cycle spindle orientation checkpoint|vesicle-mediated transport	guanyl-nucleotide exchange factor activity	cellular bud
YPL271W	YPL271W	ATP15	hom	Verified	0.841949360762617	0.199908149566718	no	880	0.232782719479827	748	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	MITOCHONDRION		Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated	ATP synthesis coupled proton transport	hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism	proton-transporting ATP synthase complex, catalytic core F(1)|mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase, central stalk
YJL160C_p	YJL160C	YJL160C	hom	Uncharacterized	0.841633731539982	0.199996501063541	no	881	0.233710343787103	816	NA					Putative protein of unknown function; member of the PIR (proteins with internal repeats) family of cell wall proteins; non-essential gene that is required for sporulation; mRNA is weakly cell cycle regulated, peaking in mitosis; YJL160C has a paralog, PIR1, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YDR206W	YDR206W	EBS1	hom	Verified	0.841215947882818	0.200113483910419	no	882	0.207165196314757	619	NA	FT	TRANSLATION	NUCLEUS|CHROMOSOME		Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors	negative regulation of translation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	molecular_function	cytoplasmic mRNA processing body|cytoplasm
YDR247W	YDR247W	VHS1	hom	Verified	0.840093685611796	0.200427930112471	no	883	0.174729062063455	597	NA	FT	CELL CYCLE|PROTEIN PHOSPHORYLATION			Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p	protein phosphorylation|G1/S transition of mitotic cell cycle	protein serine/threonine kinase activity|protein kinase activity	cytoplasm
YNL074C	YNL074C	MLF3	hom	Verified	0.838083574380544	0.200991883663025	no	884	0.185012278534875	619	NA					Serine-rich protein of unknown function, predicted to be palmitoylated; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide	response to drug	molecular_function	cytoplasm
YLR126C	YLR126C	YLR126C	hom	Verified	0.837802399649749	0.201070845411203	no	885	0.189224710687636	660	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS			Putative glutamine amidotransferase; has Aft1p-binding motif in the promoter; may be involved in copper and iron homeostasis; YLR126C is not an essential protein; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress	cellular copper ion homeostasis|cellular iron ion homeostasis	molecular_function	cytoplasm
YMR041C	YMR041C	ARA2	hom	Verified	0.837627161675038	0.201120066558054	no	886	0.192316676452962	599	NA	FT	OXIDATION-REDUCTION PROCESS			NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase	dehydro-D-arabinono-1,4-lactone biosynthetic process	D-arabinose 1-dehydrogenase [NAD(P)+] activity	cellular_component
YAR030C_d	YAR030C	YAR030C	hom	Dubious	0.837197196357277	0.201240866576087	no	887	0.194183390291749	682	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YAR029W and the verified gene PRM9	Unknown	Unknown	Unknown
YFR048W	YFR048W	RMD8	hom	Verified	0.836160428498557	0.201532328408014	no	888	0.201179859417333	685	NA	FT	CELL CYCLE			Cytosolic protein required for sporulation	biological_process	molecular_function	cytoplasm
YEL008W_d	YEL008W	YEL008W	hom	Dubious	0.835581699687683	0.201695133745333	no	889	0.183205750200033	625	NA					Hypothetical protein predicted to be involved in metabolism	Unknown	Unknown	Unknown
YLL042C	YLL042C	ATG10	hom	Verified	0.83453649639684	0.201989365072949	no	890	0.176503983357272	579	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Conserved E2-like conjugating enzyme that mediates formation of the Atg12p-Atg5p conjugate, which is a critical step in autophagy	piecemeal microautophagy of nucleus|cellular protein modification process|mitochondrion degradation|macroautophagy|CVT pathway	Atg12 ligase activity	cellular_component
YMR100W	YMR100W	MUB1	hom	Verified	0.832061162447019	0.202687211119207	no	891	0.220985811120523	723	NA	FT	CELL DIVISION			MYND domain-containing protein required for ubiquitination and turnover of Rpn4p; interacts with Ubr2p (E3) and indirectly with Rad6p (E2); short-lived protein degraded in a Ubr2p/Rad6p dependent manner; similar to the A. nidulans samB gene	regulation of cell budding|protein monoubiquitination	molecular_function	cellular_component
YOR106W	YOR106W	VAM3	hom	Verified	0.831075534046768	0.202965480016586	no	892	0.238586497178226	840	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|RESPONSE TO NUTRIENT LEVELS			Syntaxin-like vacuolar t-SNARE that functions with Vam7p in vacuolar protein trafficking; mediates docking/fusion of late transport intermediates with the vacuole; has an acidic di-leucine sorting signal and C-terminal transmembrane region	autophagic vacuole fusion|vesicle fusion with vacuole|piecemeal microautophagy of nucleus|vacuole fusion, non-autophagic|vesicle docking|vesicle fusion	protein homodimerization activity|SNAP receptor activity	SNARE complex|fungal-type vacuole membrane
YOR300W_d	YOR300W	YOR300W	hom	Dubious	0.83095459971289	0.202999638676859	no	893	0.181553170937777	600	NA					Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7	Unknown	Unknown	Unknown
YGL178W	YGL178W	MPT5	hom	Verified	0.83054333744083	0.203115827968164	no	894	0.178799934048943	612	NA	FT	TRANSLATION			mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity	negative regulation of translation|negative regulation of translational initiation|Unknown	mRNA binding|protein binding, bridging	cytoplasm
YBR288C	YBR288C	APM3	hom	Verified	0.830524196655632	0.203121236565068	no	895	0.226598293337509	786	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway	Golgi to vacuole transport|vesicle-mediated transport	molecular_function	AP-3 adaptor complex
YOR183W_p	YOR183W	FYV12	hom	Uncharacterized	0.830223421887733	0.203206237549612	no	896	0.201027383447024	701	NA					Protein of unknown function, required for survival upon exposure to K1 killer toxin	biological_process	molecular_function	cellular_component
YDR218C	YDR218C	SPR28	hom	Verified	0.829898647481373	0.203298044830943	no	897	0.181837052224825	607	NA	FT	CELL CYCLE|CELL DIVISION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; meiotic septin expressed at high levels during meiotic divisions and ascospore formation	sexual sporulation resulting in formation of a cellular spore	structural molecule activity	spindle microtubule|meiotic spindle|septin complex|prospore membrane|ascospore wall
YHR017W	YHR017W	YSC83	hom	Verified	0.828733607308417	0.203627582173398	no	898	0.231604991063695	842	NA	FT		MITOCHONDRION		Non-essential mitochondrial protein of unknown function; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion
YNL004W	YNL004W	HRB1	hom	Verified	0.827778950821717	0.203897848751698	no	899	0.211369724223036	721	NA	FT	RNA LOCALIZATION	NUCLEUS		Poly(A+) RNA-binding protein; involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Npl3p; HRB1 has a paralog, GBP2, that arose from the whole genome duplication	poly(A)+ mRNA export from nucleus	RNA binding	integral to membrane|nucleus|cytoplasm
YMR282C	YMR282C	AEP2	hom	Verified	0.825693592204581	0.204488964054509	no	900	0.240131088551081	811	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial protein, likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader	mitochondrial translational initiation	molecular_function	mitochondrion
YOR058C	YOR058C	ASE1	hom	Verified	0.823646143861688	0.205070324412068	no	901	0.170912073671085	614	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION	NUCLEUS|CYTOSKELETON		Mitotic spindle midzone localized protein; microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate; relative distribution to microtubules decreases upon DNA replication stress	cytokinesis, completion of separation|mitotic anaphase B|microtubule bundle formation|spindle pole body separation|spindle midzone assembly|mitotic spindle stabilization|mitotic spindle elongation	microtubule binding	spindle midzone|nuclear microtubule|spindle
YER137C_p	YER137C	YER137C	hom	Uncharacterized	0.823473497554439	0.205119391137349	no	902	0.21111938635675	752	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YPL133C	YPL133C	RDS2	hom	Verified	0.823078852063419	0.205231577058528	no	903	0.173593834301657	576	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|SIGNALING|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Transcription factor involved in regulating gluconeogenesis and glyoxylate cycle genes; member of the zinc cluster family of proteins; confers resistance to ketoconazole	positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source|positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter|cellular response to xenobiotic stimulus|positive regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|cytoplasm
YNL239W	YNL239W	LAP3	hom	Verified	0.820828505829855	0.205871979528557	no	904	0.194442036524003	655	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|PROTEOLYSIS	MITOCHONDRION		Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH	response to antibiotic|negative regulation of transcription from RNA polymerase II promoter|homocysteine catabolic process	double-stranded DNA binding|cysteine-type peptidase activity|mRNA binding|single-stranded DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding	mitochondrion|cytoplasm
YER072W	YER072W	VTC1	hom	Verified	0.820822235632871	0.205873765552866	no	905	0.202594392780465	644	NA	FT	MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT	ENDOPLASMIC RETICULUM		Subunit of the vacuolar transporter chaperone (VTC) complex; VTC complex is involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; also has mRNA binding activity; protein abundance increases in response to DNA replication stress	polyphosphate metabolic process|vacuolar transport|microautophagy|vacuole fusion, non-autophagic	mRNA binding	integral to membrane|endoplasmic reticulum|vacuolar transporter chaperone complex|intrinsic to vacuolar membrane
YJR087W_d	YJR087W	YJR087W	hom	Dubious	0.820542772046116	0.205953378249361	no	906	0.198514353310448	709	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified genes STE18 and ECM2	Unknown	Unknown	Unknown
YDR402C	YDR402C	DIT2	hom	Verified	0.819992799733267	0.206110105929681	no	907	0.219772181495895	736	NA	FT	CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS			N-formyltyrosine oxidase, sporulation-specific microsomal enzyme involved in the production of N,N-bisformyl dityrosine required for spore wall maturation, homologous to cytochrome P-450s	ascospore wall assembly	oxidoreductase activity	cellular_component
YGR214W	YGR214W	RPS0A	hom	Verified	0.819357610082641	0.206291206290492	no	908	0.204660654071965	687	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION		RIBOSOME	Ribosomal 40S subunit protein S0A; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2; RPS0A has a paralog, RPS0B, that arose from the whole genome duplication;	cytoplasmic translation|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA export from nucleus|ribosomal small subunit assembly|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit|90S preribosome
YBR056W	YBR056W	YBR056W	hom	Verified	0.818482079830368	0.206540985235178	no	909	0.191960344389129	683	NA	FT	CARBOHYDRATE METABOLISM			Putative glycoside hydrolase of the mitochondrial intermembrane space	biological_process	molecular_function	cytoplasm
YDR200C	YDR200C	VPS64	hom	Verified	0.815855092482163	0.207291509585321	no	910	0.253967911874895	858	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|SIGNALING|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein required for cytoplasm to vacuole targeting of proteins; forms a complex with Far3p and Far7p to Far11p involved in recovery from pheromone-induced cell cycle arrest; mutant has increased aneuploidy tolerance	re-entry into mitotic cell cycle after pheromone arrest|protein targeting to vacuole	molecular_function	endoplasmic reticulum membrane|cytoplasm
YGR187C	YGR187C	HGH1	hom	Verified	0.815844828262512	0.207294445208963	no	911	0.207325842262659	725	NA					Nonessential protein of unknown function; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16); relative distribution to the nucleus increases upon DNA replication stress	biological_process	molecular_function	cytoplasm
YBR057C	YBR057C	MUM2	hom	Verified	0.815217322209786	0.207473962101205	no	912	0.217065185248762	733	NA	FT	CELL CYCLE			Cytoplasmic protein essential for meiotic DNA replication and sporulation; interacts with Orc2p, which is a component of the origin recognition complex	premeiotic DNA replication	molecular_function	cytoplasm
YML022W	YML022W	APT1	hom	Verified	0.814738197993819	0.207611091771429	no	913	0.161822013986259	540	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		Adenine phosphoribosyltransferase; catalyzes the formation of AMP from adenine and 5-phosphoribosylpyrophosphate; involved in the salvage pathway of purine nucleotide biosynthesis; APT1 has a paralog, APT2, that arose from the whole genome duplication	AMP biosynthetic process|adenine salvage	adenine phosphoribosyltransferase activity	nucleus|cytoplasm
YPL026C	YPL026C	SKS1	hom	Verified	0.814736009325261	0.207611718310958	no	914	0.146949254449501	511	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN PHOSPHORYLATION	NUCLEUS		Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway	glucose transport|protein phosphorylation|response to glucose stimulus|positive regulation of transcription from RNA polymerase II promoter	protein serine/threonine kinase activity|protein kinase activity	nucleus|cytoplasm
YBR191W	YBR191W	RPL21A	hom	Verified	0.81341896949316	0.207988943492967	no	915	0.222886557732304	746	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YOR251C	YOR251C	TUM1	hom	Verified	0.812643767083141	0.208211165213559	no	916	0.172828077038721	608	NA	FT	RNA PROCESSING	MITOCHONDRION		Rhodanese domain sulfur transferase, accepts persulfite from Nfs1p and transfers it to Uba4p in the pathway for 2-thiolation of the wobble uridine base of tRNAs; also stimulates sulfur transfer by Nfs1p; may be mitochondrially localized	tRNA wobble position uridine thiolation|tRNA wobble uridine modification	thiosulfate sulfurtransferase activity	cytoplasm
YDL133C-A	YDL133C-A	RPL41B	hom	Verified	0.812334725471747	0.208299795001696	no	917	0.192208634591181	666	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YPR074C	YPR074C	TKL1	hom	Verified	0.811790794002954	0.208455842706754	no	918	0.254403520742009	891	NA	FF|FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS			Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication	pentose-phosphate shunt	transketolase activity	cytoplasm
YKL198C	YKL198C	PTK1	hom	Verified	0.811740241623314	0.208470349105692	no	919	0.212033831347221	699	NA	FT	PROTEIN PHOSPHORYLATION			Putative serine/threonine protein kinase that regulates spermine uptake; involved in polyamine transport; possible mitochondrial protein	polyamine transport	protein kinase activity	cellular_component
YDR417C_d	YDR417C	YDR417C	hom	Dubious	0.81118883491936	0.208628618209137	no	920	0.216183088372136	721	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RPL12B/YDR418W	Unknown	Unknown	Unknown
YDL133W	YDL133W	SRF1	hom	Verified	0.811089032794285	0.20865727177098	no	921	0.268335528381143	871	NA					Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients	positive regulation of catalytic activity	molecular_function	integral to membrane
YKL176C	YKL176C	LST4	hom	Verified	0.810381787929736	0.20886039086069	no	922	0.235209373640418	782	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM		Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface	intracellular protein transport|vesicle-mediated transport|protein transport|Golgi to plasma membrane transport	protein transporter activity	vesicle coat
YDR024W_d	YDR024W	FYV1	hom	Dubious	0.809456171269043	0.20912640175217	no	923	0.227752130014751	783	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; mutation decreases survival upon exposure to K1 killer toxin	Unknown	Unknown	Unknown
YDR165W	YDR165W	TRM82	hom	Verified	0.809291857601397	0.209173644328529	no	924	0.23227068076539	760	NA	FT	RNA PROCESSING	NUCLEUS		Catalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p	tRNA methylation	tRNA (guanine-N7-)-methyltransferase activity	tRNA methyltransferase complex|nucleus
YDR436W	YDR436W	PPZ2	hom	Verified	0.809056875100942	0.209241216141868	no	925	0.202421900810164	669	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance	cellular sodium ion homeostasis	protein serine/threonine phosphatase activity	cellular_component
YNL229C	YNL229C	URE2	hom	Verified	0.806600382383166	0.209948376687252	no	926	0.270407020939366	928	NA	FF|FT	PROTEIN LOCALIZATION			Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion	regulation of nitrogen utilization|response to aluminum ion|protein urmylation|cytoplasmic sequestering of transcription factor	glutathione peroxidase activity|phosphoprotein binding|transcription corepressor activity	cytosol
YEL033W_p	YEL033W	MTC7	hom	Uncharacterized	0.805213037741453	0.210348377066585	no	927	0.25648059611732	875	NA					Predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant	biological_process	molecular_function	cellular_component
YOR213C	YOR213C	SAS5	hom	Verified	0.805184930592983	0.210356485565032	no	928	0.234133420858504	800	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME	HISTONE ACETYLTRANSFERASE	Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity	chromatin silencing at telomere	acetyltransferase activity|histone acetyltransferase activity	nuclear chromatin|SAS acetyltransferase complex|nuclear chromosome, telomeric region
YIR018C-A_p	YIR018C-A	YIR018C-A	hom	Uncharacterized	0.804000760686739	0.210698267846212	no	929	0.200290918177268	691	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YLR227C	YLR227C	ADY4	hom	Verified	0.803596826046114	0.210814928380189	no	930	0.186975829982024	644	NA	FT	CELL CYCLE|CELL DIVISION	NUCLEUS|CYTOSKELETON		Structural component of the meiotic outer plaque, which is a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane	sporulation resulting in formation of a cellular spore	structural molecule activity	spindle pole body
YHR041C	YHR041C	SRB2	hom	Verified	0.802469845346212	0.211140612374152	no	931	0.260497385751282	882	NA	FT	TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|RESPONSE TO NUTRIENT LEVELS	NUCLEUS	RNA POL II, HOLOENZYME	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance	negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to chemical stimulus|RNA polymerase II transcriptional preinitiation complex assembly|negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to nutrient levels|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly|core RNA polymerase II binding transcription factor activity|RNA polymerase II transcription factor recruiting transcription factor activity|TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly|protein domain specific binding	core mediator complex
YOR161C-C_p	YOR161C-C	YOR161C-C	hom	Uncharacterized	0.799663159448554	0.211952991592655	no	932	0.188012779915347	623	NA					Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YJR077C	YJR077C	MIR1	hom	Verified	0.799518353651141	0.211994954341566	no	933	0.20494857779607	723	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated	phosphate ion transmembrane transport	inorganic phosphate transmembrane transporter activity	mitochondrion|integral to membrane|integral to mitochondrial inner membrane
YFL054C_p	YFL054C	YFL054C	hom	Uncharacterized	0.799340285371662	0.21204656276568	no	934	0.202113067216825	676	NA					Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol	water transport|transmembrane transport	water channel activity|glycerol transmembrane transporter activity|transporter activity	integral to membrane
YLR449W	YLR449W	FPR4	hom	Verified	0.798844728292186	0.212190225666501	no	935	0.215123343515798	735	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones	histone peptidyl-prolyl isomerization|negative regulation of histone H3-K36 methylation|regulation of transcription by chromatin organization|chromatin silencing at rDNA|nucleosome assembly	peptidyl-prolyl cis-trans isomerase activity|macrolide binding	chromatin|nucleus
YBR030W	YBR030W	RKM3	hom	Verified	0.797834373802739	0.212483305476176	no	936	0.182393429045594	630	NA	FT		NUCLEUS		Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 40); nuclear SET domain containing protein	peptidyl-lysine monomethylation	protein-lysine N-methyltransferase activity	nucleus
YGR122W	YGR122W	YGR122W	hom	Verified	0.796791293125358	0.212786126326127	no	937	0.246054401553208	882	NA	FF|FT	TRANSCRIPTION FROM RNA POL II			Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress	negative regulation of transcription from RNA polymerase II promoter|nuclear-transcribed mRNA catabolic process, non-stop decay	molecular_function	cytoplasm
YGR111W_p	YGR111W	YGR111W	hom	Uncharacterized	0.79667407061223	0.212820173394584	no	938	0.245290687347586	829	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	regulation of cell size	molecular_function	nucleus|cytoplasm
YHR141C	YHR141C	RPL42B	hom	Verified	0.795909713329763	0.213042257551743	no	939	0.238035893105242	758	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L42B; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus; homologous to mammalian ribosomal protein L36A, no bacterial homolog; RPL42B has a paralog, RPL42A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YER084W_p	YER084W	YER084W	hom	Uncharacterized	0.79530843962704	0.213217052716808	no	940	0.223336485442129	762	NA					Protein of unknown function; expressed at both mRNA and protein levels	biological_process	molecular_function	cellular_component
YDR083W	YDR083W	RRP8	hom	Verified	0.795051763469849	0.213291696031932	no	941	0.195011243813851	669	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS|CHROMOSOME		Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase; methylates adenine (m1A) of the large subunit (LSU) rRNA at position 645; involved in pre-rRNA cleavage at site A2; mutation is synthetically lethal with a gar1 mutation; deletion disrupts telomere maintenance by influencing the expression of neighboring gene STN1	rRNA processing	methyltransferase activity	nucleolus
YOR295W	YOR295W	UAF30	hom	Verified	0.795002566540565	0.213306004600793	no	942	0.203543213529742	708	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS		Subunit of UAF (upstream activation factor); UAF is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; deletion decreases cellular growth rate; UAF30 has a paralog, TRI1, that arose from the whole genome duplication	transcription of nuclear large rRNA transcript from RNA polymerase I promoter|chromatin organization	RNA polymerase I upstream control element sequence-specific DNA binding|RNA polymerase I upstream control element sequence-specific DNA binding transcription factor activity	nucleolus|RNA polymerase I upstream activating factor complex
YGR181W	YGR181W	TIM13	hom	Verified	0.79473409473239	0.213384097532147	no	943	0.17657947544816	601	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial intermembrane space protein, forms a complex with Tim8p that delivers a subset of hydrophobic proteins to the TIM22 complex for insertion into the inner membrane	protein import into mitochondrial inner membrane	protein transporter activity	mitochondrion|integral to membrane|mitochondrial intermembrane space protein transporter complex|mitochondrial intermembrane space
YKL039W	YKL039W	PTM1	hom	Verified	0.794715911925567	0.213389387139501	no	944	0.202208523965974	676	NA	FT		ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Protein of unknown function; copurifies with late Golgi vesicles containing the v-SNARE Tlg2p; PTM1 has a paralog, YHL017W, that arose from the whole genome duplication	biological_process	molecular_function	integral to membrane
YHR087W	YHR087W	RTC3	hom	Verified	0.793132825276741	0.213850219932468	no	945	0.240821822406836	854	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1); null mutation suppresses cdc13-1 temperature sensitivity; protein abundance increases in response to DNA replication stress	RNA metabolic process	molecular_function	nucleus|cytoplasm
YDL009C_p	YDL009C	YDL009C	hom	Uncharacterized	0.792003156049993	0.214179417995946	no	946	0.21108454646574	726	NA					Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the verified ORF YDL010W; YDL009C is not an essential gene	biological_process	molecular_function	cellular_component
YPL096C-A	YPL096C-A	ERI1	hom	Verified	0.790660201605896	0.214571153078178	no	947	0.249999679274407	861	NA	FT	LIPID METABOLISM|SIGNALING	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Endoplasmic reticulum membrane protein that binds to and inhibits GTP-bound Ras2p at the ER; component of the GPI-GnT complex which catalyzes the first step in GPI-anchor biosynthesis; probable homolog of mammalian PIG-Y protein	GPI anchor biosynthetic process|Ras protein signal transduction	GTPase inhibitor activity	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|endoplasmic reticulum membrane
YJL164C	YJL164C	TPK1	hom	Verified	0.790517118342608	0.214612914499288	no	948	0.210453778407355	707	NA	FT	CELL CYCLE|SIGNALING|CELL DIVISION|PROTEIN PHOSPHORYLATION	NUCLEUS		cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; regulates Whi3p; partially redundant with Tpk2p and Tpk3p; TPK1 has a paralog, TPK3, that arose from the whole genome duplication	protein phosphorylation|Ras protein signal transduction	cAMP-dependent protein kinase activity|protein kinase activity	cAMP-dependent protein kinase complex|nucleus|cytoplasm
YHR161C	YHR161C	YAP1801	hom	Verified	0.789889930262314	0.214796026340431	no	949	0.216866220029733	786	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON		Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1801 has a paralog, YAP1802, that arose from the whole genome duplication	endocytosis	clathrin binding	actin cortical patch
YKR095W	YKR095W	MLP1	hom	Verified	0.789569068229843	0.214889739286945	no	950	0.206986909761342	661	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON		Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs	protein localization to nuclear pore|poly(A)+ mRNA export from nucleus|protein import into nucleus|transcriptional activation by promoter-terminator looping|nuclear retention of unspliced pre-mRNA at the site of transcription|telomere tethering at nuclear periphery	ribonucleoprotein complex binding	nucleoplasm|nuclear envelope|integral to membrane|ribonucleoprotein complex|spindle pole body
YPR147C_p	YPR147C	YPR147C	hom	Uncharacterized	0.789502179990623	0.21490927807012	no	951	0.223245750196942	790	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	cytoplasm
YBL019W	YBL019W	APN2	hom	Verified	0.788108054387985	0.215316752168879	no	952	0.186329398851511	572	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Class II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII	base-excision repair	DNA-(apurinic or apyrimidinic site) lyase activity|double-stranded DNA specific 3'-5' exodeoxyribonuclease activity|phosphoric diester hydrolase activity	nucleus
YOR216C	YOR216C	RUD3	hom	Verified	0.787752479999661	0.215420750919835	no	953	0.215290300455861	753	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	GOLGI APPARATUS		Golgi matrix protein involved in the structural organization of the cis-Golgi; interacts genetically with COG3 and USO1	ER to Golgi vesicle-mediated transport	molecular_function	Golgi apparatus
YDR215C_d	YDR215C	YDR215C	hom	Dubious	0.787710962735918	0.21543289583004	no	954	0.21611278601226	689	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein	Unknown	Unknown	Unknown
YGR136W	YGR136W	LSB1	hom	Verified	0.787156258162809	0.215595199857287	no	955	0.176225061288729	575	NA	FT		NUCLEUS		Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YPR149W	YPR149W	NCE102	hom	Verified	0.787141897362853	0.215599402703228	no	956	0.200043292841822	718	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION	ENDOPLASMIC RETICULUM|MITOCHONDRION|PLASMA MEMBRANE		Protein of unknown function; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs)	eisosome assembly|protein secretion|negative regulation of protein phosphorylation|plasma membrane organization|establishment of protein localization to plasma membrane	molecular_function	mitochondrion|integral to membrane|membrane raft|endoplasmic reticulum|cellular bud membrane|plasma membrane|mating projection membrane|cytoplasm
YOR265W	YOR265W	RBL2	hom	Verified	0.787001265906485	0.215640562555137	no	957	0.234507864435084	797	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	CYTOSKELETON		Protein involved in microtubule morphogenesis; required for protection from excess free beta-tubulin; proposed to be involved the folding of beta-tubulin; similar to mouse beta-tubulin cofactor A; protein abundance increases in response to DNA replication stress	tubulin complex assembly|tubulin complex biogenesis	tubulin binding|beta-tubulin binding	cytoplasm
YJL211C_d	YJL211C	YJL211C	hom	Dubious	0.78640237752066	0.215815895521228	no	958	0.214789591544064	725	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL210W/PEX2	Unknown	Unknown	Unknown
YLR085C	YLR085C	ARP6	hom	Verified	0.784875022472355	0.216263423983234	no	959	0.262385281313989	922	NA	FF|FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A	chromatin remodeling|histone exchange	nucleosome binding	Swr1 complex|cytoplasm
YPL150W_p	YPL150W	YPL150W	hom	Uncharacterized	0.783541575286088	0.216654574659772	no	960	0.184457604920983	618	NA	FT	PROTEIN PHOSPHORYLATION			Protein kinase of unknown cellular role; binds phosphatidylinositols and cardiolipin in a large-scale study	protein phosphorylation	protein kinase activity	cellular_component
YKL213C	YKL213C	DOA1	hom	Verified	0.783135540853235	0.216773761194177	no	961	0.202821291664256	692	NA	FT	RESPONSE TO DNA DAMAGE|PROTEOLYSIS	NUCLEUS		WD repeat protein required for ubiquitin-mediated protein degradation; forms a complex with Cdc48p; plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon DNA replication stress	double-strand break repair via nonhomologous end joining|ubiquitin-dependent protein catabolic process	ubiquitin binding	nucleus|cytoplasm
YAR031W	YAR031W	PRM9	hom	Verified	0.781664926768108	0.21720575951724	no	962	0.220675052291981	694	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Pheromone-regulated protein with 3 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; member of DUP240 gene family	vesicle organization	molecular_function	integral to membrane|endoplasmic reticulum|plasma membrane
YDR522C	YDR522C	SPS2	hom	Verified	0.781365250813724	0.217293851390761	no	963	0.196342389108284	690	NA	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS	PLASMA MEMBRANE		Protein expressed during sporulation; SPS2 has a paralog, SPS22, that arose from the whole genome duplication; redundant with Sps22p for organization of the beta-glucan layer of the spore wall; S. pombe ortholog is a spore wall component	ascospore wall assembly|ascospore formation	molecular_function	fungal-type cell wall|plasma membrane
YGR235C	YGR235C	MOS2	hom	Verified	0.781339382059402	0.217301456661987	no	964	0.236081457167804	815	NA	FT	MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial inner membrane protein; non-essential component of the mitochondrial inner membrane organizing system (MINOS, MitOS, or MICOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture	cristae formation	molecular_function	mitochondrion|mitochondrial crista junction|integral to mitochondrial inner membrane
YKR029C	YKR029C	SET3	hom	Verified	0.780845977260963	0.217446544379086	no	965	0.222323259244119	763	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Defining member of the SET3 histone deacetylase complex which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains; SET3 has a paralog, SET4, that arose from the whole genome duplication	negative regulation of meiosis|regulation of transcription, DNA-dependent|histone deacetylation	methylated histone residue binding	Rpd3L-Expanded complex|Set3 complex
YLR143W	YLR143W	DPH6	hom	Verified	0.779815235210837	0.217749818710718	no	966	0.245875263051099	841	NA					Diphthamide synthetase; catalyzes the last amidation step of diphthamide biosynthesis using ammonium and ATP; evolutionarily conserved in eukaryotes; dph6 mutants exhibit diphthine accumulation and resistance to sordarin, which is indicative of defects in diphthamide formation on EF2; green fluorescent protein (GFP)-tagged protein localizes to the cytoplasm; DPH6/YLR143W is not an essential gene	biological_process	molecular_function	cytoplasm
YJR037W_d	YJR037W	YJR037W	hom	Dubious	0.779590932319641	0.217815847466966	no	967	0.196996001787375	605	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene HUL4/YJR036C; deletion mutant has decreased spore survival in Drosophila feces	Unknown	Unknown	Unknown
YLR133W	YLR133W	CKI1	hom	Verified	0.779125717120115	0.21795283115555	no	968	0.26314190658673	912	NA	FT	LIPID METABOLISM			Choline kinase; catalyzes the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; CKI1 has a paralog, EKI1, that arose from the whole genome duplication	phosphatidylethanolamine biosynthetic process|phosphatidylcholine biosynthetic process	ethanolamine kinase activity|choline kinase activity	cytoplasm
YDR271C_d	YDR271C	YDR271C	hom	Dubious	0.779080835318466	0.217966049332359	no	969	0.250877291721628	855	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W	Unknown	Unknown	Unknown
YIL041W	YIL041W	GVP36	hom	Verified	0.776768705724658	0.218647621530423	no	970	0.237217433115125	788	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		BAR domain-containing protein that localizes to both early and late Golgi vesicles; required for adaptation to varying nutrient concentrations, fluid-phase endocytosis, polarization of the actin cytoskeleton, and vacuole biogenesis	vacuole organization|endocytosis|establishment or maintenance of actin cytoskeleton polarity	molecular_function	integral to Golgi membrane|cytoplasm
YOR347C	YOR347C	PYK2	hom	Verified	0.776421421725626	0.218750100172258	no	971	0.188336051837	651	NA	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Pyruvate kinase; appears to be modulated by phosphorylation; transcription repressed by glucose, and Pyk2p may be active under low glycolytic flux; PYK2 has a paralog, CDC19, that arose from the whole genome duplication	pyruvate metabolic process	pyruvate kinase activity	cytosol|mitochondrion
YBR147W	YBR147W	RTC2	hom	Verified	0.77636779112467	0.218765928274654	no	972	0.195546436635229	656	NA	FT		MITOCHONDRION		Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; positive regulation by Lys14p suggests that lysine may be the primary substrate; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter	biological_process	molecular_function	mitochondrion|integral to membrane
YLR284C	YLR284C	ECI1	hom	Verified	0.776237869279403	0.218804275090817	no	973	0.220532721941171	725	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS			Peroxisomal delta3,delta2-enoyl-CoA isomerase, hexameric protein that converts 3-hexenoyl-CoA to trans-2-hexenoyl-CoA, essential for the beta-oxidation of unsaturated fatty acids, oleate-induced	fatty acid beta-oxidation	dodecenoyl-CoA delta-isomerase activity	peroxisome
YOR367W	YOR367W	SCP1	hom	Verified	0.776005901346682	0.218872750727734	no	974	0.237409613707683	833	NA	FT	CYTOSKELETON ORGANIZATION	CYTOSKELETON		Component of yeast cortical actin cytoskeleton, binds and cross links actin filaments; originally identified by its homology to calponin (contains a calponin-like repeat) but the Scp1p domain structure is more similar to transgelin	actin filament organization|chronological cell aging	actin filament binding|protein binding, bridging	actin cortical patch
YOR365C_p	YOR365C	YOR365C	hom	Uncharacterized	0.775007879495288	0.219167501792829	no	975	0.198375349668078	696	NA					Putative protein of unknown function; not an essential protein; YOR365C has a paralog, FLC2, that arose from the whole genome duplication	biological_process	molecular_function	integral to membrane
YLR052W	YLR052W	IES3	hom	Verified	0.774802290216564	0.219228247894295	no	976	0.220232753196015	723	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Subunit of the INO80 chromatin remodeling complex	nucleosome mobilization|telomere maintenance|chromatin silencing at telomere	molecular_function	nucleus|Ino80 complex
YDR059C	YDR059C	UBC5	hom	Verified	0.77455676562736	0.219300806484932	no	977	0.218491854318742	708	NA					Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived, abnormal, or excess proteins, including histone H3; central component of the cellular stress response; expression is heat inducible; protein abundance increases in response to DNA replication stress; UBC5 has a paralog, UBC4, that arose from the whole genome duplication	protein polyubiquitination|response to stress	ubiquitin-protein ligase activity	proteasome complex
YOR096W	YOR096W	RPS7A	hom	Verified	0.773167776340285	0.219711546996898	no	978	0.256072111576801	841	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION	NUCLEUS	RIBOSOME	Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7A has a paralog, RPS7B, that arose from the whole genome duplication	cytoplasmic translation|ribosome biogenesis	structural constituent of ribosome	small-subunit processome|cytosolic small ribosomal subunit|90S preribosome
YKR057W	YKR057W	RPS21A	hom	Verified	0.773025656452597	0.21975359841798	no	979	0.219753707239732	771	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21A has a paralog, RPS21B, that arose from the whole genome duplication	cytoplasmic translation|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit
YBR073W	YBR073W	RDH54	hom	Verified	0.772600922544735	0.219879299176161	no	980	0.245015254249422	863	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS		DNA-dependent ATPase; stimulates strand exchange by modifying the topology of double-stranded DNA; involved in recombinational repair of DNA double-strand breaks during mitosis and meiosis; proposed to be involved in crossover interference; interacts with Dmc1p; stimulates Dmc1p and Rad51p	DNA geometric change|heteroduplex formation|meiotic sister chromatid segregation|reciprocal meiotic recombination|double-strand break repair via break-induced replication	DNA-dependent ATPase activity|DNA translocase activity	nucleus
YNR030W	YNR030W	ALG12	hom	Verified	0.771914897117277	0.220082416753998	no	981	0.251152924904742	835	NA	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Alpha-1,6-mannosyltransferase localized to the ER; responsible for the addition of the alpha-1,6 mannose to dolichol-linked Man7GlcNAc2, acts in the dolichol pathway for N-glycosylation	dolichol-linked oligosaccharide biosynthetic process|protein glycosylation	alpha-1,6-mannosyltransferase activity	integral to membrane|endoplasmic reticulum
YGL072C_d	YGL072C	YGL072C	hom	Dubious	0.771751522102149	0.220130804494158	no	982	0.255089688049826	910	NA	FF				Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2	Unknown	Unknown	Unknown
YKR043C	YKR043C	SHB17	hom	Verified	0.771627177281589	0.220167636520863	no	983	0.262568772963734	884	NA	FT	CARBOHYDRATE METABOLISM	NUCLEUS		Sedoheptulose bisphosphatase involved in riboneogenesis; dephosphorylates sedoheptulose 1,7-bisphosphate, which is converted via the nonoxidative pentose phosphate pathway to ribose-5-phosphate; facilitates the conversion of glycolytic intermediates to pentose phosphate units; also has fructose 1,6-bisphosphatase activity but this is probably not biologically relevant, since deletion does not affect FBP levels; GFP-fusion protein localizes to the cytoplasm and nucleus	ribose phosphate biosynthetic process	sedoheptulose-bisphosphatase activity	nucleus|cytoplasm
YLR250W	YLR250W	SSP120	hom	Verified	0.771616326888048	0.220170850670272	no	984	0.220199329372905	716	NA					Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	biological_process	molecular_function	cytoplasm
YOR014W	YOR014W	RTS1	hom	Verified	0.771569807852141	0.220184631040594	no	985	0.248446187965504	894	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|SIGNALING|CHROMOSOME SEGREGATION	NUCLEUS|SITE OF POLARIZED GROWTH|CHROMOSOME|CYTOSKELETON		B-type regulatory subunit of protein phosphatase 2A (PP2A); Rts1p and Cdc55p are alternative regulatory subunits for PP2A catalytic subunits, Pph21p and Pph22p; PP2A-Rts1p protects cohesin when recruited by Sgo1p to the pericentromere; highly enriched at centromeres in the absence of Cdc55p; required for maintenance of septin ring organization during cytokinesis, for ring disassembly in G1 and for dephosphorylation of septin, Shs1p; homolog of the mammalian B' subunit of PP2A	mitotic cell cycle spindle orientation checkpoint|cellular protein localization|meiotic sister chromatid cohesion, centromeric|protein dephosphorylation	protein serine/threonine phosphatase activity	nucleus|spindle pole body|condensed nuclear chromosome, centromeric region|cellular bud neck|cytoplasm
YCR091W	YCR091W	KIN82	hom	Verified	0.770235792958192	0.220580017736965	no	986	0.197503421229591	704	NA	FT	MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION			Putative serine/threonine protein kinase implicated in the regulation of phospholipid asymmetry through the activation of phospholipid translocases (flippases) Lem3p-Dnf1p/Dnf2p; similar to Fpk1p	phospholipid translocation|protein phosphorylation|response to pheromone	protein kinase activity	cellular_component
YGR221C	YGR221C	TOS2	hom	Verified	0.770006291752402	0.220648080246408	no	987	0.210259558902992	725	NA	FT	CELL DIVISION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Protein involved in localization of Cdc24p to the site of bud growth; may act as a membrane anchor; localizes to the bud neck and bud tip; potentially phosphorylated by Cdc28p	budding cell bud growth	molecular_function	cellular bud neck|cellular bud tip
YKL117W	YKL117W	SBA1	hom	Verified	0.769052565254906	0.220931053001362	no	988	0.204101286135426	659	NA	FT		NUCLEUS		Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins, and like p23 can regulate telomerase activity; protein abundance increases in response to DNA replication stress	protein folding|positive regulation of telomere maintenance via telomerase|regulation of telomerase activity	chaperone binding	nucleus|cytoplasm
YJL145W	YJL145W	SFH5	hom	Verified	0.767874723405145	0.221280807808805	no	989	0.191776395209773	681	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Non-classical phosphatidylinositol transfer protein (PITP); exhibits PI- but not PC-transfer activity; localizes to the peripheral endoplasmic reticulum, cytosol and microsomes; similar to Sec14p; partially relocalizes to the plasma membrane upon DNA replication stress	Golgi to plasma membrane protein transport|phosphatidylinositol metabolic process|Unknown|regulation of exocytosis|phospholipid transport	phosphatidylinositol transporter activity|phosphatidylcholine transporter activity	cell periphery|cytosol|plasma membrane|cortical endoplasmic reticulum
YML113W	YML113W	DAT1	hom	Verified	0.766981675931645	0.221546205168538	no	990	0.206125952679961	722	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		DNA binding protein that recognizes oligo(dA).oligo(dT) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; not essential for viability	negative regulation of transcription from RNA polymerase II promoter	AT DNA binding	nucleus
YGL218W_d	YGL218W	YGL218W	hom	Dubious	0.766977929558664	0.221547318905089	no	991	0.262052490479354	902	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 93% of ORF overlaps the verified gene MDM34; deletion in cyr1 mutant results in loss of stress resistance	Unknown	Unknown	Unknown
YBR107C	YBR107C	IML3	hom	Verified	0.766803260398175	0.221599248795478	no	992	0.205193720492844	732	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME	KINETOCHORE	Outer kinetochore protein and component of the Ctf19 complex; involved in the establishment of pericentromeric cohesion during mitosis; prevents non-disjunction of sister chromatids during meiosis II; required for localization of Sgo1p to pericentric sites during meiosis I; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-L and fission yeast fta1	establishment of meiotic sister chromatid cohesion|ascospore formation|protein localization to chromosome, centromeric region|meiotic sister chromatid segregation|maintenance of meiotic sister chromatid cohesion|establishment of mitotic sister chromatid cohesion	molecular_function	condensed nuclear chromosome outer kinetochore
YBL013W	YBL013W	FMT1	hom	Verified	0.766636941182156	0.221648702676546	no	993	0.253144549265498	851	NA	FT	KETONE METABOLISM|RNA PROCESSING|AMINO ACID METABOLISM|TRANSLATION	MITOCHONDRION		Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate	translational initiation|methionyl-tRNA aminoacylation	methionyl-tRNA formyltransferase activity	mitochondrion
YPL269W	YPL269W	KAR9	hom	Verified	0.766400046624212	0.221719152540274	no	994	0.270839031813596	942	NA	FT		NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON		Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase	nuclear migration along microtubule|establishment of spindle localization	molecular_function	cell cortex|spindle pole body|mating projection tip
YER117W	YER117W	RPL23B	hom	Verified	0.765691012406678	0.221930088033736	no	995	0.218194659426917	760	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L23B; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23B has a paralog, RPL23A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YJR105W	YJR105W	ADO1	hom	Verified	0.76552939339767	0.221978185223191	no	996	0.285200487953759	993	NA	FF|FT	NUCLEOTIDE METABOLISM	NUCLEUS		Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle	purine nucleobase metabolic process	adenosine kinase activity	nucleus|cytoplasm
YGR108W	YGR108W	CLB1	hom	Verified	0.765317751377663	0.222041178065511	no	997	0.203907902093794	725	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	NUCLEUS		B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome	G2/M transition of mitotic cell cycle|meiotic G2/MI transition|regulation of cyclin-dependent protein kinase activity|mitotic spindle organization in nucleus|positive regulation of spindle pole body separation	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex|nucleus|cytoplasm
YER055C	YER055C	HIS1	hom	Verified	0.765232133165733	0.2220666642524	no	998	0.22148600011924	757	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			ATP phosphoribosyltransferase, a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control	histidine biosynthetic process	ATP phosphoribosyltransferase activity	cellular_component
YIL100W_d	YIL100W	YIL100W	hom	Dubious	0.765053722582852	0.222119777541139	no	999	0.231214401127642	757	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YIL100C-A	Unknown	Unknown	Unknown
YGR243W	YGR243W	FMP43	hom	Verified	0.764621226971213	0.222248562684697	no	1000	0.22141778356703	794	NA	FT		MITOCHONDRION		Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; more highly expressed in glucose-containing minimal medium than in lactate-containing medium; expression regulated by osmotic and alkaline stresses; protein abundance increases in response to DNA replication stress	mitochondrial pyruvate transport	pyruvate transmembrane transporter activity	mitochondrion|mitochondrial membrane
YIR018W	YIR018W	YAP5	hom	Verified	0.76424803672352	0.222359722578358	no	1001	0.209268616331683	744	NA	FT	TRANSCRIPTION FROM RNA POL II|GENE SILENCING	NUCLEUS|CHROMOSOME		Basic leucine zipper (bZIP) iron-sensing transcription factor; YAP5 has a paralog, YAP7, that arose from the whole genome duplication	negative regulation of chromatin silencing at telomere|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter in response to iron|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding RNA polymerase II transcription factor activity	nuclear chromatin|nucleus
YKL179C	YKL179C	COY1	hom	Verified	0.764082713183098	0.222408976624094	no	1002	0.133328326142665	438	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function	Golgi vesicle transport	molecular_function	Golgi membrane
YDL104C	YDL104C	QRI7	hom	Verified	0.76404970583307	0.222418811090004	no	1003	0.227800943605314	737	NA	FT	RNA PROCESSING|PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Highly conserved mitochondrial protein, essential for t6A modification of mitochondrial tRNAs that decode ANN codons; similar to Kae1p and E. coli YgjD, both of which are also required for tRNA t6A modification	mitochondrial tRNA threonylcarbamoyladenosine modification	molecular_function	mitochondrion
YNL105W_d	YNL105W	RRT16	hom	Dubious	0.761570394708697	0.223158224957542	no	1004	0.189001967481596	613	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription	Unknown	Unknown	Unknown
YBR028C	YBR028C	YPK3	hom	Verified	0.761510463143493	0.223176115869742	no	1005	0.254969453353745	841	NA	FT	PROTEIN PHOSPHORYLATION			An AGC kinase phosphorylated by cAMP-dependent protein kinase (PKA) in a TORC1-dependent manner	biological_process	protein kinase activity	cytoplasm
YDR369C	YDR369C	XRS2	hom	Verified	0.761267067696655	0.223248783244147	no	1006	0.236288283953471	829	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS		Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling	double-strand break repair via nonhomologous end joining|meiotic DNA double-strand break formation|base-excision repair|telomere maintenance|sporulation resulting in formation of a cellular spore|double-strand break repair via break-induced replication	single-stranded telomeric DNA binding|protein binding, bridging|DNA binding|double-stranded telomeric DNA binding|telomeric DNA binding|G-quadruplex DNA binding	nucleus|Mre11 complex
YDR430C	YDR430C	CYM1	hom	Verified	0.760988008293561	0.223332114906261	no	1007	0.192525349114532	582	NA	FT	PROTEOLYSIS	MITOCHONDRION		Lysine-specific metalloprotease of the mitochondrial intermembrane space, member of the pitrilysin family; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology	proteolysis|proteolysis involved in cellular protein catabolic process	metalloendopeptidase activity	mitochondrion|mitochondrial intermembrane space
YGR177C	YGR177C	ATF2	hom	Verified	0.760759373188848	0.223400402245718	no	1008	0.205797872788939	679	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Alcohol acetyltransferase, may play a role in steroid detoxification; forms volatile esters during fermentation, which is important for brewing and winemaking	steroid metabolic process|response to toxin|Unknown|sterol acetylation	alcohol O-acetyltransferase activity	integral to endoplasmic reticulum membrane|endoplasmic reticulum|cytoplasm
YDR163W	YDR163W	CWC15	hom	Verified	0.760482658939516	0.223483065459122	no	1009	0.220508827967607	749	NA	FT	RNA PROCESSING	NUCLEUS		Non-essential protein involved in pre-mRNA splicing, component of a complex containing Cef1p; has similarity to S. pombe Cwf15p	mRNA splicing, via spliceosome	molecular_function	U2-type spliceosomal complex
YLL007C_p	YLL007C	YLL007C	hom	Uncharacterized	0.755471072915473	0.224983191292582	no	1010	0.251394055540784	909	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL007C is not an essential gene	biological_process	molecular_function	cytoplasm
YMR238W	YMR238W	DFG5	hom	Verified	0.755201338878267	0.22506409272255	no	1011	0.251550035065646	881	NA	FT	CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM	PLASMA MEMBRANE		Putative mannosidase, essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis in bud formation, involved in filamentous growth, homologous to Dcw1p	pseudohyphal growth|fungal-type cell wall biogenesis|budding cell bud growth	mannosidase activity	anchored to plasma membrane
YOR097C_p	YOR097C	YOR097C	hom	Uncharacterized	0.754641797102723	0.225231968849037	no	1012	0.245611277903523	872	NA					Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; YOR097C is not an essential gene	biological_process	molecular_function	cellular_component
YBR183W	YBR183W	YPC1	hom	Verified	0.754464543286003	0.225285164089165	no	1013	0.2351956383564	800	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Alkaline ceramidase; also has reverse (CoA-independent) ceramide synthase activity; catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistance; YPC1 has a paralog, YDC1, that arose from the whole genome duplication	ceramide catabolic process|ceramide biosynthetic process	phytoceramidase activity|sphingosine N-acyltransferase activity	integral to membrane|endoplasmic reticulum
YLR406C	YLR406C	RPL31B	hom	Verified	0.753979269641612	0.225430834858024	no	1014	0.259425753035147	896	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L31B; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31B has a paralog, RPL31A, that arose from the whole genome duplication	cytoplasmic translation|regulation of translational fidelity	structural constituent of ribosome	cytosolic large ribosomal subunit
YPL065W	YPL065W	VPS28	hom	Verified	0.753035806709513	0.225714198697031	no	1015	0.247231082290214	875	NA	FF|FT	PROTEIN LOCALIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT			Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p	protein targeting to membrane|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein targeting to vacuole	protein complex binding	endosome|ESCRT I complex
YER038W-A_d	YER038W-A	YER038W-A	hom	Dubious	0.752606141365711	0.225843313039752	no	1016	0.233146792168344	764	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 99% of ORF overlaps the verified gene HVG1; protein product detected in mitochondria	Unknown	Unknown	Unknown
YDR387C_p	YDR387C	YDR387C	hom	Uncharacterized	0.75234718605829	0.225921149221916	no	1017	0.198043744030262	669	NA					Putative transporter, member of the sugar porter family; YDR387C is not an essential gene	transport|transmembrane transport	substrate-specific transmembrane transporter activity	integral to membrane|membrane
YBL001C	YBL001C	ECM15	hom	Verified	0.75227274049491	0.225943528702455	no	1018	0.209386955261442	689	NA	FT	CELL WALL ORG/BIOGENESIS	NUCLEUS		Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis	fungal-type cell wall organization	molecular_function	nucleus|cytoplasm
YFR010W	YFR010W	UBP6	hom	Verified	0.751875343761781	0.226063013469521	no	1019	0.270063880380757	919	NA	FT	PROTEOLYSIS			Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains; works in opposition to Hul5p polyubiquitin elongation activity; mutant has aneuploidy tolerance	protein deubiquitination	ubiquitin-specific protease activity	proteasome complex|proteasome regulatory particle
YGR176W_d	YGR176W	YGR176W	hom	Dubious	0.751512516841141	0.226172135357946	no	1020	0.205837953427233	701	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR259C	YMR259C	TRM732	hom	Verified	0.751070487431011	0.226305117975059	no	1021	0.237633030658732	799	NA					Interacts with Trm7p for 2'-O-methylation of C32 of substrate tRNAs; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; non-essential gene	biological_process	molecular_function	cytoplasm
YDL118W_d	YDL118W	YDL118W	hom	Dubious	0.750874156449131	0.226364197455886	no	1022	0.261058743882254	902	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Dubious open reading frame, unlikely to encode a protein; overlaps almost completely with YDL119C; mutations that would affect both YDL118W and YDL119C confer defective telomere maintenance and are synthetically sick or lethal with alpha-synuclein	biological_process	molecular_function	cellular_component
YHR127W	YHR127W	YHR127W	hom	Verified	0.748285926750884	0.227143855666339	no	1023	0.217609672267121	725	NA	FT	CELL CYCLE|CYTOSKELETON ORGANIZATION	NUCLEUS		Protein of unknown function; localizes to the nucleus; required for asymmetric localization of Kar9p during mitosis	mitotic spindle elongation	molecular_function	nucleus
YOR252W	YOR252W	TMA16	hom	Verified	0.747733320155469	0.227310514466642	no	1024	0.215481647513193	737	NA	FT		NUCLEUS		Protein of unknown function that associates with ribosomes	biological_process	molecular_function	ribosome|nucleus
YPL038W-A_p	YPL038W-A	YPL038W-A	hom	Uncharacterized	0.747140039663792	0.227489516641671	no	1025	0.203406572684661	681	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YJL106W	YJL106W	IME2	hom	Verified	0.746512995875965	0.2276787920064	no	1026	0.218472835859625	720	NA	FT	CELL CYCLE|PROTEIN PHOSPHORYLATION	NUCLEUS		Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p	protein phosphorylation|regulation of meiosis	protein kinase activity	nucleus
YGR205W	YGR205W	TDA10	hom	Verified	0.746138848117687	0.227791772035367	no	1027	0.199387997729727	681	NA	FT		NUCLEUS		ATP-binding protein of unknown function; crystal structure resembles that of E.coli pantothenate kinase and other small kinases; null mutant is sensitive to expression of the top1-T722A allele	biological_process	ATP binding	nucleus|cytoplasm
YML007W	YML007W	YAP1	hom	Verified	0.745984730279313	0.227838319608316	no	1028	0.250776697250801	851	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Basic leucine zipper (bZIP) transcription factor; required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; Yap1p is degraded in the nucleus after the oxidative stress has passed; mediates resistance to cadmium; YAP1 has a paralog, CAD1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress	positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance|response to heat|response to drug|response to singlet oxygen|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|response to metal ion	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus|cytoplasm
YOL164W	YOL164W	BDS1	hom	Verified	0.74426623910295	0.228357710820477	no	1029	0.24720231791467	837	NA					Bacterially-derived sulfatase required for use of alkyl- and aryl-sulfates as sulfur sources	dodecyl sulfate metabolic process	arylsulfatase activity|alkyl sulfatase activity	cellular_component
YMR251W	YMR251W	GTO3	hom	Verified	0.743836681838775	0.228487642690394	no	1030	0.240433866551757	832	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Omega class glutathione transferase; putative cytosolic localization	glutathione metabolic process	glutathione transferase activity	cytoplasm
YOR228C	YOR228C	YOR228C	hom	Verified	0.743439811825027	0.228607724270806	no	1031	0.234345888940122	799	NA	FT		MITOCHONDRION		Protein of unknown function, localized to the mitochondrial outer membrane	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion|integral to membrane
YOR154W_p	YOR154W	SLP1	hom	Uncharacterized	0.74277749729328	0.228808200721903	no	1032	0.197752113996515	671	NA					Glycosylated integral ER membrane protein of unknown function; forms an ER-membrane associated protein complex with Emp65p; member of the SUN-like family of proteins; genetic interactions suggest a role in folding of ER membrane proteins; required for nuclear envelope localization of Mps3p	protein folding in endoplasmic reticulum	molecular_function	cellular_component
YNL268W	YNL268W	LYP1	hom	Verified	0.742404590191722	0.22892111964497	no	1033	0.237777428820566	844	NA	FT		MITOCHONDRION|PLASMA MEMBRANE		Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids	basic amino acid transport	basic amino acid transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YHL001W	YHL001W	RPL14B	hom	Verified	0.74237260468396	0.228930806540248	no	1034	0.219845846468883	726	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L14B; homologous to mammalian ribosomal protein L14, no bacterial homolog; RPL14B has a paralog, RPL14A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YLR040C_p	YLR040C	YLR040C	hom	Uncharacterized	0.741834030379399	0.2290939497277	no	1035	0.235005632240258	785	NA					Protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; mRNA identified as translated by ribosome profiling data; YLR040C is not essential	biological_process	molecular_function	fungal-type cell wall
YKL064W	YKL064W	MNR2	hom	Verified	0.741384624778555	0.229230132117434	no	1036	0.222063007509612	755	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Vacuolar membrane protein required for magnesium homeostasis; putative magnesium transporter; has similarity to Alr1p and Alr2p, which mediate influx of Mg2+ and other divalent cations	cellular magnesium ion homeostasis	magnesium ion transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane
YLR387C	YLR387C	REH1	hom	Verified	0.740044604687444	0.229636464803955	no	1037	0.267101355911548	919	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS		RIBOSOME	Cytoplasmic 60S subunit biogenesis factor, associates with pre-60S particles; similar to Rei1p and shares partially redundant function in cytoplasmic 60S subunit maturation; contains dispersed C2H2 zinc finger domains	ribosomal large subunit biogenesis|budding cell bud growth	molecular_function	cytosolic large ribosomal subunit|preribosome, large subunit precursor|cytoplasm
YDR051C	YDR051C	DET1	hom	Verified	0.739665067414573	0.229751624713769	no	1038	0.215768936611988	687	NA	FT		NUCLEUS		Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel	intracellular sterol transport|dephosphorylation	acid phosphatase activity	nucleus|cytoplasm
YMR021C	YMR021C	MAC1	hom	Verified	0.739496591985995	0.229802754206053	no	1039	0.332382433522457	1164	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|ION HOMEOSTASIS|ION HOMEOSTASIS	NUCLEUS		Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport	cellular copper ion homeostasis|positive regulation of protein catabolic process|positive regulation of transcription from RNA polymerase II promoter	core promoter proximal region DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YDL023C_d	YDL023C	YDL023C	hom	Dubious	0.738998158080867	0.22995405791199	no	1040	0.24225102408181	833	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance	Unknown	Unknown	Unknown
YIR020W-A_d	YIR020W-A	YIR020W-A	hom	Dubious	0.737918203391191	0.230282078235238	no	1041	0.243498891058425	846	NA					Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data	Unknown	Unknown	Unknown
YOR111W_p	YOR111W	YOR111W	hom	Uncharacterized	0.737173611799113	0.230508389276735	no	1042	0.212399574911863	739	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YPR045C	YPR045C	THP3	hom	Verified	0.736723968035155	0.230645114102799	no	1043	0.222642742473824	781	NA	FT	RNA PROCESSING	NUCLEUS|CHROMOSOME		Protein that forms a complex with Csn12p that is recruited to transcribed genes and may have a role in transcription elongation; possibly involved in splicing based on pre-mRNA accumulation defect for many intron-containing genes	mRNA splicing, via spliceosome	molecular_function	nucleus|transcriptionally active chromatin
YLR031W_p	YLR031W	YLR031W	hom	Uncharacterized	0.736156338945932	0.230817779845824	no	1044	0.245004065994046	834	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YNR057C	YNR057C	BIO4	hom	Verified	0.736148792809589	0.230820075773221	no	1045	0.250026502822344	872	NA	FT	KETONE METABOLISM|COFACTOR METABOLISM			Dethiobiotin synthetase, catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; expression appears to be repressed at low iron levels	biotin biosynthetic process	dethiobiotin synthase activity	cytoplasm
YIL043C	YIL043C	CBR1	hom	Verified	0.736136669750662	0.230823764265366	no	1046	0.242220406962378	817	NA	FT	OXIDATION-REDUCTION PROCESS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		Microsomal cytochrome b reductase, not essential for viability; also detected in mitochondria; mutation in conserved NADH binding domain of the human ortholog results in type I methemoglobinemia	biological_process	cytochrome-b5 reductase activity	mitochondrial outer membrane|mitochondrion
YDR222W_p	YDR222W	YDR222W	hom	Uncharacterized	0.735879897255525	0.230901896118847	no	1047	0.26239285009613	888	NA	FT	RESPONSE TO OXIDATIVE STRESS			Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	biological_process	molecular_function	cytoplasm
YCR007C_p	YCR007C	YCR007C	hom	Uncharacterized	0.73541355976238	0.23104383307869	no	1048	0.24576691618311	821	NA					Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene	biological_process	molecular_function	cellular_component
YKL041W	YKL041W	VPS24	hom	Verified	0.735391249674072	0.231050624716252	no	1049	0.249981871788736	867	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM		One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); forms an ESCRT-III subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway	intralumenal vesicle formation|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|late endosome to vacuole transport	molecular_function	ESCRT III complex|cytoplasm
YNL136W	YNL136W	EAF7	hom	Verified	0.735146411225028	0.231125165763283	no	1050	0.25511597695887	889	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS	HISTONE ACETYLTRANSFERASE	Subunit of the NuA4 histone acetyltransferase complex, which acetylates the N-terminal tails of histones H4 and H2A	DNA repair|histone acetylation|regulation of transcription from RNA polymerase II promoter	molecular_function	histone acetyltransferase complex|nucleus|NuA4 histone acetyltransferase complex
YLR252W_d	YLR252W	YLR252W	hom	Dubious	0.734395226336086	0.23135394767283	no	1051	0.245881820236956	819	NA					Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SYM1, a mitochondrial protein involved in ethanol metabolism	Unknown	Unknown	Unknown
YDR025W	YDR025W	RPS11A	hom	Verified	0.733922789971612	0.231497898217008	no	1052	0.239486136228217	810	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11A has a paralog, RPS11B, that arose from the whole genome duplication	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal small subunit assembly	structural constituent of ribosome	cytosolic small ribosomal subunit|90S preribosome
YLR122C_d	YLR122C	YLR122C	hom	Dubious	0.733285416296636	0.231692183977871	no	1053	0.23836617821372	766	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C	Unknown	Unknown	Unknown
YAR029W_p	YAR029W	YAR029W	hom	Uncharacterized	0.73310247177243	0.23174796634102	no	1054	0.222456295986435	768	NA					Member of DUP240 gene family but contains no transmembrane domains; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	biological_process	molecular_function	cytoplasm
YOL017W	YOL017W	ESC8	hom	Verified	0.731759566264971	0.232157666129348	no	1055	0.238632043990078	826	NA	FT	GENE SILENCING	NUCLEUS		Protein involved in telomeric and mating-type locus silencing; interacts with Sir2p and also interacts with Gal11p, which is a component of the RNA pol II mediator complex; ESC8 has a paralog, IOC3, that arose from the whole genome duplication	chromatin silencing	molecular_function	nucleus
YHR021C	YHR021C	RPS27B	hom	Verified	0.73142144868301	0.232260884086351	no	1056	0.247449955166055	826	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27B has a paralog, RPS27A, that arose from the whole genome duplication	cytoplasmic translation|ribosomal small subunit assembly|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit
YDL078C	YDL078C	MDH3	hom	Verified	0.731277293993506	0.232304898293457	no	1057	0.198752479083159	669	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM			Peroxisomal malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle	glyoxylate cycle|fatty acid beta-oxidation|malate metabolic process|NADH regeneration	L-malate dehydrogenase activity|mRNA binding	peroxisomal matrix|peroxisome
YOR350C	YOR350C	MNE1	hom	Verified	0.730586588758801	0.232515853086805	no	1058	0.235982316937256	810	NA	FT	RNA PROCESSING	MITOCHONDRION		Mitochondrial matrix protein involved in splicing Group I aI5-beta intron from COX1 mRNA	Group I intron splicing	molecular_function	mitochondrion|ribonucleoprotein complex|mitochondrial matrix
YDR306C_p	YDR306C	YDR306C	hom	Uncharacterized	0.730307611163529	0.23260108845414	no	1059	0.24955929886666	837	NA	FT	PROTEOLYSIS			F-box protein of unknown function; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity|protein binding, bridging	SCF ubiquitin ligase complex
YNR001C	YNR001C	CIT1	hom	Verified	0.729893663678562	0.232727592856769	no	1060	0.244397371780293	860	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein; CIT1 has a paralog, CIT2, that arose from the whole genome duplication	glutamate biosynthetic process|tricarboxylic acid cycle|acetyl-CoA catabolic process|citrate metabolic process	citrate (Si)-synthase activity	mitochondrion
YER097W_d	YER097W	YER097W	hom	Dubious	0.729723299347326	0.232779668145161	no	1061	0.274878835027691	943	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR304W	YMR304W	UBP15	hom	Verified	0.729206688915398	0.232937620106818	no	1062	0.26599171425782	867	NA	FT	PROTEOLYSIS			Ubiquitin-specific protease involved in protein deubiquitination; catalytic activity regulated by an N-terminal TRAF-like domain and and C-terminal sequences; physically interacts with anaphase-promoting complex/cyclosome (APC/C) activator, Cdh1p; forms a complex with AAA peroxins Pex1p and Pex6p	protein deubiquitination	ubiquitin-specific protease activity	peroxisome|cytoplasm
YBR015C	YBR015C	MNN2	hom	Verified	0.729016755365531	0.232995706636384	no	1063	0.312666491561988	1076	NA	FF|FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment	protein glycosylation	alpha-1,2-mannosyltransferase activity	Golgi apparatus
YER140W	YER140W	EMP65	hom	Verified	0.728899858978344	0.233031460535257	no	1064	0.225105168641689	778	NA	FT		MITOCHONDRION		ER membrane protein of unknown function; forms an ER-membrane associated protein complex with Slp1p; identified along with SLP1 in a screen for mutants defective in the unfolded protein response (UPR); proposed to function in the folding of integral membrane proteins; interacts genetically with MPS1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	protein folding in endoplasmic reticulum	molecular_function	mitochondrion|integral to membrane
YCR003W	YCR003W	MRPL32	hom	Verified	0.728625797783757	0.233115296765401	no	1065	0.260218936620453	891	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit
YBR163W	YBR163W	EXO5	hom	Verified	0.728345641926521	0.233201014678481	no	1066	0.236046074356705	833	NA	FT	MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial 5'-3' exonuclease and sliding exonuclease, required for mitochondrial genome maintenance; distantly related to the RecB nuclease domain of bacterial RecBCD recombinases; may be regulated by the transcription factor Ace2	mitochondrial genome maintenance	single-stranded DNA specific 5'-3' exodeoxyribonuclease activity	mitochondrion
YFR017C	YFR017C	IGD1	hom	Verified	0.728120731900267	0.233269841954316	no	1067	0.237994568502625	791	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Cytoplasmic protein that inhibits Gdb1p glycogen debranching activity; required for normal intracellular accumulation of glycogen; phosphorylated in vivo; expression increases during wine fermentation; protein abundance increases in response to DNA replication stress; IGD1 has a paralog, YOL024W, that arose from the whole genome duplication	negative regulation of glycogen catabolic process	enzyme inhibitor activity	cytoplasm
YHR139C-A_d	YHR139C-A	YHR139C-A	hom	Dubious	0.727588699632487	0.233432700068864	no	1068	0.224629380757856	769	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR099C	YMR099C	YMR099C	hom	Verified	0.726922388614962	0.233636750607111	no	1069	0.251893652050973	854	NA	FT	CARBOHYDRATE METABOLISM	NUCLEUS		Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS	cellular carbohydrate metabolic process	glucose-6-phosphate 1-epimerase activity	nucleus|cytoplasm
YCL058C	YCL058C	FYV5	hom	Verified	0.726581211366218	0.233741270718711	no	1070	0.22112004551862	745	NA	FT	SIGNALING|ION HOMEOSTASIS|ION HOMEOSTASIS			Protein involved in regulation of the mating pathway; binds with Matalpha2p to promoters of haploid-specific genes; required for survival upon exposure to K1 killer toxin; involved in ion homeostasis	pheromone-dependent signal transduction involved in conjugation with cellular fusion|cellular ion homeostasis	molecular_function	integral to membrane
YJL161W_p	YJL161W	FMP33	hom	Uncharacterized	0.726020345935213	0.233913148913031	no	1071	0.210901339041796	713	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YLR090W	YLR090W	XDJ1	hom	Verified	0.725410025209417	0.234100262302362	no	1072	0.25081981487502	841	NA	FT		NUCLEUS|MITOCHONDRION		Chaperone with a role in facilitating mitochondrial protein import; ascomycete-specific member of the DnaJ-like family, closely related to Ydj1p; predicted to be C-terminally prenylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	protein folding	chaperone binding	mitochondrion|integral to mitochondrial outer membrane|nucleus
YCL026C-B	YCL026C-B	HBN1	hom	Verified	0.725290330015263	0.234136968422011	no	1073	0.246048088941059	848	NA	FT	OXIDATION-REDUCTION PROCESS	NUCLEUS		Protein of unknown function; similar to bacterial nitroreductases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein becomes insoluble upon intracellular iron depletion; protein abundance increases in response to DNA replication stress	biological_process	NAD(P)H nitroreductase activity	nucleus|cytoplasm
YBR301W	YBR301W	PAU24	hom	Verified	0.724995034533604	0.234227538328329	no	1074	0.22518273824555	767	NA	FT	CELL WALL ORG/BIOGENESIS			Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth	biological_process	molecular_function	fungal-type cell wall
YDL063C	YDL063C	SYO1	hom	Verified	0.724589519531095	0.234351945199286	no	1075	0.253404850562551	855	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS	NUCLEUS		Transport adaptor or symportin; facilitates synchronized nuclear coimport of the two 5S-rRNA binding proteins Rpl5p and Rpl11p; required for biogenesis of the large ribosomal subunit; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus	ribosomal large subunit biogenesis	molecular_function	nucleus|cytoplasm
YNR014W_p	YNR014W	YNR014W	hom	Uncharacterized	0.724506808760145	0.234377324306384	no	1076	0.249630613629048	842	NA					Putative protein of unknown function; expression is cell-cycle regulated, Azf1p-dependent, and heat-inducible; YNR014W has a paralog, YMR206W, that arose from the whole genome duplication	biological_process	molecular_function	cytoplasm
YGL166W	YGL166W	CUP2	hom	Verified	0.72382292921734	0.234587225281806	no	1077	0.244110794604574	824	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations; CUP2 has a paralog, HAA1, that arose from the whole genome duplication	regulation of transcription from RNA polymerase II promoter|response to copper ion	RNA polymerase II core promoter proximal region sequence-specific DNA binding|copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity|copper ion binding	nucleus
YKR016W	YKR016W	FCJ1	hom	Verified	0.723113819160375	0.234804979928592	no	1078	0.222338407224102	733	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial inner membrane protein, ortholog of mammalian mitofilin; involved in import of intermembrane space (IMS) proteins, probably by positioning Mia40p relative to the TOM complex to receive incoming proteins; also has an essential role in the maintenance of crista junctions and inner membrane architecture, as a component of the mitochondrial inner membrane organizing system (MICOS, MitOS or MINOS), a scaffold-like structure on the IMS side of the inner membrane	cristae formation|protein import into mitochondrial intermembrane space	molecular_function	mitochondrion|mitochondrial inner membrane|mitochondrial crista|mitochondrial crista junction|integral to mitochondrial inner membrane
YMR177W	YMR177W	MMT1	hom	Verified	0.723048363450147	0.234825085803747	no	1079	0.236196517319315	836	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt2p	cellular iron ion homeostasis	molecular_function	mitochondrion|integral to membrane
YBR119W	YBR119W	MUD1	hom	Verified	0.722876590565625	0.234877853398157	no	1080	0.260114977959595	901	NA	FT	RNA PROCESSING	NUCLEUS		U1 snRNP A protein, homolog of human U1-A; involved in nuclear mRNA splicing	mRNA splicing, via spliceosome	U1 snRNA binding|RNA binding	U1 snRNP|U2-type prespliceosome
YLR403W	YLR403W	SFP1	hom	Verified	0.72210460117876	0.235115084772206	no	1081	0.225429473945556	787	NA	FT	TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS	NUCLEUS		Regulates transcription of ribosomal protein and biogenesis genes; regulates response to nutrients and stress, G2/M transitions during mitotic cell cycle and DNA-damage response, and modulates cell size; regulated by TORC1 and Mrs6p; sequence of zinc finger, ChIP localization data, and protein-binding microarray (PBM) data, and computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p at others; can form the [ISP+] prion	positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter|regulation of cell size|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II transcription factor binding transcription factor activity	nucleus|cytoplasm
YJR032W	YJR032W	CPR7	hom	Verified	0.721651764831491	0.235254302375877	no	1082	0.24999697450276	880	NA					Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity	protein refolding|response to stress	unfolded protein binding|peptidyl-prolyl cis-trans isomerase activity	cytosol
YBR085C-A	YBR085C-A	YBR085C-A	hom	Verified	0.721599810017886	0.235270277998109	no	1083	0.212536883532301	767	NA	FT		NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YKL129C	YKL129C	MYO3	hom	Verified	0.720873187443488	0.235493770440914	no	1084	0.191061691394972	614	NA	FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION	CYTOSKELETON		One of two type I myosins; localizes to actin cortical patches; deletion of MYO3 has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization	bipolar cellular bud site selection|fungal-type cell wall organization|endocytosis|exocytosis|actin cortical patch localization|response to osmotic stress	microfilament motor activity	actin cortical patch
YPR044C_d	YPR044C	OPI11	hom	Dubious	0.719681936466082	0.235860425249975	no	1085	0.235677619337304	811	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RPL43A/YPR043W; deletion confers sensitivity to GSAO	Unknown	Unknown	Unknown
YDR275W	YDR275W	BSC2	hom	Verified	0.719461002794621	0.235928460941524	no	1086	0.239772027959164	804	NA					Protein of unknown function; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; BSC2 has a paralog, IRC23, that arose from the whole genome duplication	biological_process	molecular_function	lipid particle
YML035C	YML035C	AMD1	hom	Verified	0.719374008489537	0.235955253477775	no	1087	0.234266916863579	798	NA	FT	NUCLEOTIDE METABOLISM			AMP deaminase; tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; thought to be involved in regulation of intracellular purine (adenine, guanine, and inosine) nucleotide pools	guanine salvage|purine nucleotide metabolic process	AMP deaminase activity	cytoplasm
YMR311C	YMR311C	GLC8	hom	Verified	0.719054432715059	0.236053690928524	no	1088	0.248533724276797	864	NA	FT	SIGNALING|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|CHROMOSOME SEGREGATION	NUCLEUS		Regulatory subunit of protein phosphatase 1 (Glc7p); involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2; protein abundance increases in response to DNA replication stress	chromosome segregation|glycogen biosynthetic process	enzyme activator activity	nucleus|cytoplasm
YGR152C	YGR152C	RSR1	hom	Verified	0.718969338370387	0.236079905960851	no	1089	0.233562674005822	768	NA	FT	CELL CYCLE|SIGNALING|CELL DIVISION|NUCLEOTIDE METABOLISM	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases	bipolar cellular bud site selection|small GTPase mediated signal transduction|axial cellular bud site selection|cellular bud site selection	GTPase activity|signal transducer activity	plasma membrane|cellular bud neck
YLR365W_d	YLR365W	YLR365W	hom	Dubious	0.718955034307195	0.236084312774018	no	1090	0.202608861617455	682	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious gene YLR364C-A; YLR365W is not an essential gene	Unknown	Unknown	Unknown
YDL049C	YDL049C	KNH1	hom	Verified	0.718294449407586	0.236287875939517	no	1091	0.223273975995727	748	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance	(1->6)-beta-D-glucan biosynthetic process	molecular_function	fungal-type cell wall|extracellular region
YJL099W	YJL099W	CHS6	hom	Verified	0.718178141011298	0.236323727067505	no	1092	0.25928886123663	914	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	GOLGI APPARATUS		Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication	Golgi to plasma membrane transport|fungal-type cell wall chitin biosynthetic process	molecular_function	trans-Golgi network transport vesicle|clathrin-coated vesicle|exomer complex
YPR049C	YPR049C	ATG11	hom	Verified	0.715803609512147	0.237056311667082	no	1093	0.250664118367841	854	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|PEROXISOME ORGANIZATION			Adapter protein for pexophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; directs receptor-bound cargo to the phagophore assembly site (PAS) for packaging into vesicles; required for recruiting other proteins to the (PAS)	piecemeal microautophagy of nucleus|mitochondrion degradation|peroxisome degradation|protein localization to pre-autophagosomal structure|CVT pathway	protein complex scaffold	pre-autophagosomal structure|extrinsic to membrane
YDR322W	YDR322W	MRPL35	hom	Verified	0.715592709588081	0.237121438279953	no	1094	0.256730071819537	864	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YCL001W-B_p	YCL001W-B	YCL001W-B	hom	Uncharacterized	0.715358751779075	0.237193696746256	no	1095	0.254018898567417	845	NA					Putative protein of unknown function; present in a region duplicated between chromosomes XIV and III; YCL001W-B has a paralog, DOM34, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YPR029C	YPR029C	APL4	hom	Verified	0.715346637300328	0.237197438663289	no	1096	0.215930820219193	737	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport	Golgi to vacuole transport|vesicle-mediated transport	clathrin binding	AP-1 adaptor complex
YGR217W	YGR217W	CCH1	hom	Verified	0.71517196030239	0.237251396453402	no	1097	0.237608222920713	800	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together	calcium ion transport	voltage-gated calcium channel activity|calcium channel activity	integral to membrane|plasma membrane
YGL161C	YGL161C	YIP5	hom	Verified	0.714765243981781	0.237377057396721	no	1098	0.241751524060835	828	NA	FT		GOLGI APPARATUS		Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport	biological_process	Rab GTPase binding	integral to membrane|Golgi apparatus
YCR033W	YCR033W	SNT1	hom	Verified	0.713684704945277	0.237711083147909	no	1099	0.240408841794863	827	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION|SIGNALING	NUCLEUS|CHROMOSOME		Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein; mutant has increased aneuploidy tolerance	negative regulation of meiosis|regulation of transcription, DNA-dependent|histone deacetylation|positive regulation of stress-activated MAPK cascade	molecular_function	Rpd3L-Expanded complex|Set3 complex
YCL026C-A	YCL026C-A	FRM2	hom	Verified	0.713682716048669	0.237711698210811	no	1100	0.212611762180885	747	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	NUCLEUS		Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin	cellular response to oxidative stress|negative regulation of fatty acid metabolic process	oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor	nucleus|cytoplasm
YDR248C_p	YDR248C	YDR248C	hom	Uncharacterized	0.713211513095994	0.237857441527304	no	1101	0.22078459679936	750	NA	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM			Putative gluconokinase; sequence similarity to bacterial and human gluconokinase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; upregulated by deletion of the RNAP-II associated factor, PAF1	biological_process	molecular_function	cytoplasm
YDR541C_p	YDR541C	YDR541C	hom	Uncharacterized	0.712469485498379	0.238087050352924	no	1102	0.242405592982761	831	NA	FT	OXIDATION-REDUCTION PROCESS			Putative dihydrokaempferol 4-reductase	biological_process	carbonyl reductase (NADPH) activity	cellular_component
YFL036W	YFL036W	RPO41	hom	Verified	0.711890720678554	0.238266224356732	no	1103	0.243530688401035	816	NA	FT	MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation	transcription from mitochondrial promoter|mitochondrial genome maintenance	DNA-directed RNA polymerase activity	mitochondrial nucleoid|mitochondrion|mitochondrial DNA-directed RNA polymerase complex|mitochondrial matrix
YDR358W	YDR358W	GGA1	hom	Verified	0.711737851551918	0.238313561906816	no	1104	0.22201902178808	745	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT	GOLGI APPARATUS		Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi	Golgi to vacuole transport|protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|Golgi to endosome transport	ubiquitin binding	trans-Golgi network
YDL175C	YDL175C	AIR2	hom	Verified	0.709662319123522	0.238956782069006	no	1105	0.247846192321589	853	NA	FT	RNA PROCESSING	NUCLEUS		RNA-binding subunit of the TRAMP nuclear RNA surveillance complex; involved in nuclear RNA processing and degradation; involved in TRAMP complex assembly as a bridge between Mtr4p and Trf4p; stimulates the poly(A) polymerase activity of Pap2p in vitro; has 5 zinc knuckle motifs; AIR2 has a paralog, AIR1, that arose from the whole genome duplication	nuclear polyadenylation-dependent CUT catabolic process|nuclear mRNA surveillance of mRNA 3'-end processing|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent snRNA catabolic process|ncRNA polyadenylation|tRNA modification	polynucleotide adenylyltransferase activity|RNA binding|protein binding, bridging	nucleolus|TRAMP complex
YKR015C_p	YKR015C	YKR015C	hom	Uncharacterized	0.709101113284232	0.239130866079881	no	1106	0.214581746320949	693	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YHL024W	YHL024W	RIM4	hom	Verified	0.708666107366385	0.239265851005703	no	1107	0.259726424840233	904	NA	FT	CELL CYCLE			Putative RNA-binding protein required for the expression of early and middle sporulation genes	meiosis|reciprocal meiotic recombination|sporulation resulting in formation of a cellular spore|premeiotic DNA replication	RNA binding	cytoplasm
YLR360W	YLR360W	VPS38	hom	Verified	0.708449968327601	0.239332935713612	no	1108	0.225633301376419	734	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT	GOLGI APPARATUS		Part of a Vps34p phosphatidylinositol 3-kinase complex that functions in carboxypeptidase Y (CPY) sorting; binds Vps30p and Vps34p to promote production of phosphatidylinositol 3-phosphate (PtdIns3P) which stimulates kinase activity; required for overflow degradation of misfolded proteins when ERAD is saturated	ER-associated protein catabolic process|late endosome to vacuole transport	molecular_function	phosphatidylinositol 3-kinase complex II
YJR130C	YJR130C	STR2	hom	Verified	0.707072441881987	0.23976073032682	no	1109	0.231136246261261	799	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Cystathionine gamma-synthase, converts cysteine into cystathionine	sulfur compound metabolic process|transsulfuration	cystathionine gamma-synthase activity	nucleus|cytoplasm
YLR349W_d	YLR349W	YLR349W	hom	Dubious	0.70663822595213	0.239895663706924	no	1110	0.23084562288424	775	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF DIC1/YLR348C	Unknown	Unknown	Unknown
YPL110C	YPL110C	GDE1	hom	Verified	0.706605162308667	0.239905939990259	no	1111	0.24638752258627	856	NA	FT	LIPID METABOLISM|SIGNALING|CARBOHYDRATE METABOLISM			Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes	glycerophospholipid catabolic process	glycerophosphocholine phosphodiesterase activity	ribosome|cytoplasm
YDR424C	YDR424C	DYN2	hom	Verified	0.706403273134476	0.23996869298271	no	1112	0.246311245841569	842	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON		Cytoplasmic light chain dynein, microtubule motor protein; proposed to be involved in the assembly of the nuclear pore complex	microtubule-based process|actin filament-based process|nuclear pore complex assembly	molecular_function	cytoplasmic dynein complex|cytoplasmic microtubule|peroxisome|nuclear pore
YPL267W	YPL267W	ACM1	hom	Verified	0.706022081673445	0.240087202712151	no	1113	0.247359135321248	853	NA	FT	CELL CYCLE|CELL DIVISION	NUCLEUS		Pseudosubstrate inhibitor of the anaphase-promoting complex/cyclosome (APC/C), that suppresses APC/C [Cdh1]-mediated proteolysis of mitotic cyclins; associates with Cdh1p, Bmh1p and Bmh2p; cell cycle regulated protein	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	ubiquitin-protein ligase inhibitor activity	nucleus|cytoplasm
YOR015W_d	YOR015W	YOR015W	hom	Dubious	0.705218465239427	0.240337145876986	no	1114	0.229119793497321	791	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YBR259W	YBR259W	YBR259W	hom	Verified	0.705020168416496	0.240398842540552	no	1115	0.242235265881937	819	NA					Protein of unknown function; YBR259W is not an essential gene; forms cytoplasmic foci upon DNA replication stress	biological_process	molecular_function	cellular_component
YLL054C_p	YLL054C	YLL054C	hom	Uncharacterized	0.704184895429363	0.240658818117109	no	1116	0.245697983211861	817	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene	biological_process	sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity	cellular_component
YKL085W	YKL085W	MDH1	hom	Verified	0.703953271614206	0.24073093725163	no	1117	0.246508630576425	829	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated	chronological cell aging|replicative cell aging|tricarboxylic acid cycle|aerobic respiration	L-malate dehydrogenase activity|mRNA binding	mitochondrion|mitochondrial matrix
YBR239C_p	YBR239C	ERT1	hom	Uncharacterized	0.703655606415092	0.240823636510976	no	1118	0.235393920795286	781	NA	FT	TRANSCRIPTION FROM RNA POL II|SIGNALING|CARBOHYDRATE METABOLISM	NUCLEUS		Transcriptional regulator of nonfermentable carbon utilization; GFP-fusion protein localizes to cytoplasm, nucleus; null mutation affects periodicity of transcriptional and metabolic oscillation; plays role in restricting Ty1 transposition	biological_process	sequence-specific DNA binding	nucleus|cytoplasm
YDR395W	YDR395W	SXM1	hom	Verified	0.701885555934787	0.241375268700551	no	1119	0.241092923571386	830	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS		Nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucleoplasm; similar to Nmd5p, Cse1p, Lph2p, and the human cellular apoptosis susceptibility protein, CAS1	mRNA export from nucleus|nucleocytoplasmic transport	protein transporter activity	integral to membrane|nucleus|cytoplasm
YBR061C	YBR061C	TRM7	hom	Verified	0.701738821417362	0.241421028970318	no	1120	0.238802846719537	833	NA	FT	RNA PROCESSING|TRANSLATION			2'-O-ribose methyltransferase; methylates the 2'-O-ribose of tRNA-Phe, tRNA-Trp, and tRNA-Leu at positions C32 and N34 of the tRNA anticodon loop; crucial biological role likely modification of tRNA-Phe; interacts with Trm732p and Rtt10p in 2'-O-methylation of C32 and N34 substrate tRNAs, respectively	cytoplasmic translation|tRNA methylation	tRNA methyltransferase activity	cytoplasm
YBR086C	YBR086C	IST2	hom	Verified	0.701667048126507	0.241443413730438	no	1121	0.255528587894964	851	NA	FT		PLASMA MEMBRANE		Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localizes to the mother cell in small-budded cells and to the bud in medium- and large-budded cells; mRNA is transported to the bud tip by an actomyosin-driven process	response to osmotic stress	lipid binding	integral to membrane|cellular bud membrane|plasma membrane
YPL104W	YPL104W	MSD1	hom	Verified	0.701468621031355	0.24150530533284	no	1122	0.268554562852128	940	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial aspartyl-tRNA synthetase, required for acylation of aspartyl-tRNA; yeast and bacterial aspartyl-, asparaginyl-, and lysyl-tRNA synthetases contain regions with high sequence similarity, suggesting a common ancestral gene	mitochondrial aspartyl-tRNA aminoacylation	aspartate-tRNA ligase activity	mitochondrion
YNL285W_d	YNL285W	YNL285W	hom	Dubious	0.701347175627844	0.241543189745595	no	1123	0.232022464362759	784	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPL227C	YPL227C	ALG5	hom	Verified	0.701323284127181	0.241550642984493	no	1124	0.249530932756418	877	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		UDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum	protein N-linked glycosylation	dolichyl-phosphate beta-glucosyltransferase activity	endoplasmic reticulum membrane
YOL114C_p	YOL114C	YOL114C	hom	Uncharacterized	0.701170719165144	0.24159824039095	no	1125	0.252196908761312	867	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION			Putative protein of unknown function with similarity to human ICT1 and prokaryotic factors that may function in translation termination; YOL114C is not an essential gene	biological_process	molecular_function	cellular_component
YGR101W	YGR101W	PCP1	hom	Verified	0.701111828027604	0.241616614683379	no	1126	0.255247511118993	882	NA	FT	PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial serine protease required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases	signal peptide processing|regulation of mitochondrion organization	serine-type endopeptidase activity	integral to membrane|mitochondrial inner membrane
YHL033C	YHL033C	RPL8A	hom	Verified	0.700738633909817	0.241733070515935	no	1127	0.230599814610746	778	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L8A; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8A has a paralog, RPL8B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YMR083W	YMR083W	ADH3	hom	Verified	0.700501704404879	0.241807020561422	no	1128	0.25078646118147	866	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production	NADH oxidation|fermentation|amino acid catabolic process to alcohol via Ehrlich pathway	alcohol dehydrogenase (NAD) activity	mitochondrion|mitochondrial matrix
YLR099C	YLR099C	ICT1	hom	Verified	0.700353109736561	0.241853405946936	no	1129	0.245702026316183	876	NA	FT	KETONE METABOLISM|LIPID METABOLISM			Lysophosphatidic acid acyltransferase; responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stress; ICT1 has a paralog, ECM18, that arose from the whole genome duplication	phosphatidic acid biosynthetic process	lysophosphatidic acid acyltransferase activity	cellular_component
YDR335W	YDR335W	MSN5	hom	Verified	0.700318349680911	0.241864257359926	no	1130	0.260472100576294	901	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	NUCLEUS		Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm	tRNA re-export from nucleus|protein export from nucleus	protein binding|importin-alpha export receptor activity	integral to membrane|nucleus|cytoplasm
YHR108W	YHR108W	GGA2	hom	Verified	0.699286784151068	0.242186412260328	no	1131	0.23587961242204	838	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT	GOLGI APPARATUS		Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin	protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|Golgi to vacuole transport|Golgi to endosome transport	ubiquitin binding|phosphatidylinositol-4-phosphate binding	trans-Golgi network
YML063W	YML063W	RPS1B	hom	Verified	0.699192153459034	0.242215976792717	no	1132	0.260827810037091	891	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal protein 10 (rp10) of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1B has a paralog, RPS1A, that arose from the whole genome duplication	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit|90S preribosome
YGR275W	YGR275W	RTT102	hom	Verified	0.698762409693928	0.242350262003773	no	1133	0.258323937972083	844	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|CHROMOSOME SEGREGATION	NUCLEUS	RSC COMPLEX	Component of both the SWI/SNF and RSC chromatin remodeling complexes; suggested role in chromosome maintenance; possible weak regulator of Ty1 transposition; protein abundance increases in response to DNA replication stress	chromosome segregation|nucleosome disassembly|chromatin remodeling|transcription elongation from RNA polymerase II promoter	molecular_function	RSC complex|SWI/SNF complex|nucleus
YGL254W	YGL254W	FZF1	hom	Verified	0.698739889573391	0.242357300144528	no	1134	0.251552751853356	857	NA	FT	TRANSCRIPTION FROM RNA POL II|ION HOMEOSTASIS|ION HOMEOSTASIS	NUCLEUS		Transcription factor involved in sulfite metabolism; sole identified regulatory target is SSU1; overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1, contains five zinc fingers; protein abundance increases in response to DNA replication stress	positive regulation of sulfite transport by positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YNL067W-B_p	YNL067W-B	YNL067W-B	hom	Uncharacterized	0.698220291659317	0.242519719160264	no	1135	0.258633656511854	895	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YNL173C	YNL173C	MDG1	hom	Verified	0.697608465621222	0.242711042946649	no	1136	0.258494046601222	891	NA	FT	SIGNALING	PLASMA MEMBRANE		Plasma membrane protein involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations	pheromone-dependent signal transduction involved in conjugation with cellular fusion	molecular_function	membrane raft|plasma membrane
YCR049C_d	YCR049C	YCR049C	hom	Dubious	0.697590051813147	0.242716802384796	no	1137	0.266378793211803	905	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOR054C	YOR054C	VHS3	hom	Verified	0.697558764788485	0.242726588454378	no	1138	0.25300868898041	868	NA	FT	CELL CYCLE|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|COFACTOR METABOLISM			Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis	coenzyme A biosynthetic process|cellular monovalent inorganic cation homeostasis	phosphopantothenoylcysteine decarboxylase activity|protein phosphatase inhibitor activity	phosphopantothenoylcysteine decarboxylase complex
YLR211C_p	YLR211C	YLR211C	hom	Uncharacterized	0.697370628356586	0.242785438956493	no	1139	0.227957844394414	787	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR211C is not an essential gene; ORF contains an intron	biological_process	molecular_function	cytoplasm
YPL159C	YPL159C	PET20	hom	Verified	0.697357562447726	0.242789526358602	no	1140	0.250501081429633	846	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Mitochondrial protein, required for respiratory growth under some conditions and for stability of the mitochondrial genome	aerobic respiration	molecular_function	mitochondrion
YBR156C	YBR156C	SLI15	hom	Verified	0.697214034780579	0.242834428502546	no	1141	0.241100558020207	812	NA	FT	CELL DIVISION|PROTEIN PHOSPHORYLATION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME|CYTOSKELETON		Subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly	chromosome segregation|protein phosphorylation|regulation of cytokinesis	protein kinase activator activity	spindle microtubule|spindle midzone|chromosome passenger complex|kinetochore microtubule
YOL110W	YOL110W	SHR5	hom	Verified	0.697154077214285	0.242853187354521	no	1142	0.242557060791012	831	NA	FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Subunit of a palmitoyltransferase, composed of Shr5p and Erf2p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; palmitoylation is required for Ras2p membrane localization	protein targeting to membrane|protein palmitoylation	palmitoyltransferase activity	endoplasmic reticulum palmitoyltransferase complex|extrinsic to endoplasmic reticulum membrane
YAL036C	YAL036C	RBG1	hom	Verified	0.696762751201383	0.242975640314138	no	1143	0.245991660159099	845	NA	FT	TRANSLATION		RIBOSOME	Member of the DRG family of GTP-binding proteins; associates with translating ribosomes; interacts with Tma46p, Ygr250cp, Gir2p and Yap1p via two-hybrid	cytoplasmic translation	GTP binding	polysomal ribosome|polysome|cytoplasm
YOL160W_d	YOL160W	YOL160W	hom	Dubious	0.696656383916862	0.243008930326039	no	1144	0.210381172601533	662	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGR109C	YGR109C	CLB6	hom	Verified	0.696630191478936	0.243017128211677	no	1145	0.234230286670627	813	NA	FT	CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION	NUCLEUS		B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1	regulation of cyclin-dependent protein kinase activity|G1/S transition of mitotic cell cycle|regulation of S phase of mitotic cell cycle|premeiotic DNA replication	cyclin-dependent protein kinase regulator activity	cellular_component
YKL201C	YKL201C	MNN4	hom	Verified	0.696568124508583	0.243036554947302	no	1146	0.23842034551694	788	NA	FT	CARBOHYDRATE METABOLISM			Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication	protein O-linked glycosylation|protein N-linked glycosylation|response to stress	molecular_function	membrane
YER173W	YER173W	RAD24	hom	Verified	0.695074534251216	0.243504296463222	no	1147	0.252293429087172	835	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein	reciprocal meiotic recombination|DNA damage checkpoint|nucleotide-excision repair	DNA clamp loader activity	Rad17 RFC-like complex|nucleus
YMR010W_p	YMR010W	YMR010W	hom	Uncharacterized	0.694052548417876	0.243824627546689	no	1148	0.240911463508255	816	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR010W is not an essential gene; YMR010W mRNA is transcribed with ADI1	biological_process	molecular_function	integral to membrane|cytoplasm
YJL127C-B_p	YJL127C-B	YJL127C-B	hom	Uncharacterized	0.693735249327074	0.243924127972766	no	1149	0.226953145304352	756	NA					Putative protein of unknown function; identified based on homology to the filamentous fungus, <i>Ashbya gossypii</i>	biological_process	molecular_function	cellular_component
YDR098C	YDR098C	GRX3	hom	Verified	0.692815178461768	0.244212772777243	no	1150	0.231516489150564	798	NA	FT	ION HOMEOSTASIS|CYTOSKELETON ORGANIZATION|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage; evidence exists indicating that the translation start site is not Met1 as currently annotated, but rather Met36	cellular iron ion homeostasis|cellular response to oxidative stress|actin cytoskeleton organization	disulfide oxidoreductase activity	cytosol|nucleus
YER139C	YER139C	RTR1	hom	Verified	0.69240408766108	0.244341799756958	no	1151	0.232353419113716	821	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		CTD phosphatase; dephosphorylates S5-P in the C-terminal domain of Rpo21p; has a cysteine-rich motif required for function and conserved in eukaryotes; shuttles between the nucleus and cytoplasm; RTR1 has a paralog, RTR2, that arose from the whole genome duplication	dephosphorylation of RNA polymerase II C-terminal domain|transcription from RNA polymerase II promoter	CTD phosphatase activity	nucleus|cytoplasm
YDR169C-A_p	YDR169C-A	YDR169C-A	hom	Uncharacterized	0.692280351658395	0.244380643339489	no	1152	0.261721817068624	879	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YER004W	YER004W	FMP52	hom	Verified	0.69208283846659	0.24444265417659	no	1153	0.259156550244419	883	NA	FT		ENDOPLASMIC RETICULUM|MITOCHONDRION		Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion|endoplasmic reticulum
YER001W	YER001W	MNN1	hom	Verified	0.692052921594408	0.244452047555782	no	1154	0.221263321440721	756	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family	N-glycan processing|protein O-linked glycosylation	alpha-1,3-mannosyltransferase activity	Golgi apparatus
YPL090C	YPL090C	RPS6A	hom	Verified	0.69188956102668	0.244503343372148	no	1155	0.248331114065378	854	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; RPS6A has a paralog, RPS6B, that arose from the whole genome duplication	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	small-subunit processome|cytosolic small ribosomal subunit|90S preribosome
YBR255W	YBR255W	MTC4	hom	Verified	0.691450943289851	0.244641099628969	no	1156	0.267918403150941	904	NA					Protein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; mtc4 is synthetically sick with cdc13-1	biological_process	molecular_function	cytoplasm
YIL089W	YIL089W	YIL089W	hom	Verified	0.691106290335117	0.244749373773223	no	1157	0.213003368590159	727	NA	FT		ENDOPLASMIC RETICULUM		Protein of unknown function found in the ER and vacuole lumen; overexpression of YIL089W affects endocytic protein trafficking	biological_process	molecular_function	fungal-type vacuole lumen|integral to membrane|endoplasmic reticulum
YGL149W_d	YGL149W	YGL149W	hom	Dubious	0.690278786862721	0.245009442690913	no	1158	0.234685388334828	781	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF INO80/YGL150C.	Unknown	Unknown	Unknown
YOL001W	YOL001W	PHO80	hom	Verified	0.689967577626308	0.245107288409027	no	1159	0.275121807155451	984	NA	FF|FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CELL CYCLE|SIGNALING|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Cyclin, interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling	negative regulation of phosphate metabolic process|regulation of cyclin-dependent protein kinase activity|negative regulation of calcium-mediated signaling|negative regulation of transcription from RNA polymerase II promoter|cellular metal ion homeostasis|regulation of protein localization|negative regulation of macroautophagy	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex|nucleus
YHR111W	YHR111W	UBA4	hom	Verified	0.689622967905025	0.245215659919839	no	1160	0.248937177540852	856	NA	FT	RNA PROCESSING|CELL DIVISION|RESPONSE TO OXIDATIVE STRESS			Protein that activates Urm1p before its conjugation to proteins (urmylation); also acts in thiolation of the wobble base of cytoplasmic tRNAs by adenylating and then thiolating Urm1p; receives sulfur from Tum1p	cellular response to oxidative stress|tRNA wobble position uridine thiolation|cell budding|protein urmylation|tRNA thio-modification|Unknown|invasive growth in response to glucose limitation	URM1 activating enzyme activity|sulfurtransferase activity|thiosulfate sulfurtransferase activity|protein adenylyltransferase activity	cytoplasm
YML079W_p	YML079W	YML079W	hom	Uncharacterized	0.689512329089356	0.245250458642415	no	1161	0.249823675125327	812	NA	FT		NUCLEUS		Non-essential protein of unknown function with structural resemblance to plant storage and ligand binding proteins (canavalin, glycinin, auxin binding protein) and to some enzymes (epimerase, germin); localizes to the nucleus and cytoplasm	biological_process	molecular_function	nucleus|cytoplasm
YER016W	YER016W	BIM1	hom	Verified	0.689308415989164	0.245314601455938	no	1162	0.24133611734931	842	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	CHROMOSOME|CYTOSKELETON	KINETOCHORE	Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally	nuclear migration along microtubule|microtubule nucleation|microtubule depolymerization|negative regulation of microtubule depolymerization|positive regulation of microtubule polymerization|mitotic sister chromatid cohesion|mitotic cell cycle spindle assembly checkpoint	microtubule plus-end binding|protein homodimerization activity|structural constituent of cytoskeleton	spindle midzone|microtubule plus end|cytoplasmic microtubule|spindle pole body|kinetochore|spindle pole|spindle
YOR082C_d	YOR082C	YOR082C	hom	Dubious	0.688252389532883	0.245646928892639	no	1163	0.236930346359157	771	NA					Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene YOR083W	Unknown	Unknown	Unknown
YER007W	YER007W	PAC2	hom	Verified	0.688020862627073	0.245719821815056	no	1164	0.246559875835874	858	NA	FT		CYTOSKELETON		Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl	protein folding|tubulin complex assembly|tubulin complex biogenesis	alpha-tubulin binding	cellular_component
YER134C	YER134C	YER134C	hom	Verified	0.687756039057008	0.245803211951622	no	1165	0.244315041728561	849	NA	FT		NUCLEUS		Magnesium-dependent acid phosphatase, member of the haloacid dehalogenase superfamily; non-essential gene	biological_process	acid phosphatase activity	nucleus|cytoplasm
YOR007C	YOR007C	SGT2	hom	Verified	0.687683990305794	0.24582590196861	no	1166	0.229192761267697	760	NA	FT	PROTEIN LOCALIZATION			Glutamine-rich cytoplasmic cochaperone; serves as a scaffold bringing together Get4, Get5p, and other TRC complex members that are required to mediate posttranslational insertion of tail-anchored proteins into the ER membrane; interacts with the prion domain of Sup35p; amyloid sensor; plays a role in targeting chaperones to prion aggregates; has similarity to human cochaperone SGT; forms cytoplasmic foci upon DNA replication stress	response to heat|posttranslational protein targeting to membrane	molecular_function	TRC complex|cytoplasm
YJL146W	YJL146W	IDS2	hom	Verified	0.686983133610214	0.246046678535571	no	1167	0.231681657428939	794	NA	FT	CELL CYCLE	NUCLEUS		Protein involved in modulation of Ime2p activity during meiosis, appears to act indirectly to promote Ime2p-mediated late meiotic functions; found in growing cells and degraded during sporulation	meiosis	molecular_function	nucleus|cytoplasm
YLR326W_p	YLR326W	YLR326W	hom	Uncharacterized	0.686602242028746	0.246166707626419	no	1168	0.223770884704157	733	NA					Putative protein of unknown function, predicted to be palmitoylated	biological_process	molecular_function	cellular_component
YKL124W	YKL124W	SSH4	hom	Verified	0.68617976618882	0.246299877747822	no	1169	0.197444028254846	681	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT			Specificity factor required for Rsp5p-dependent ubiquitination and sorting of cargo proteins at the multivesicular body; identified as a high-copy suppressor of a SHR3 deletion, increasing steady-state levels of amino acid permeases	protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|vesicle-mediated transport	molecular_function	fungal-type vacuole
YKR064W	YKR064W	OAF3	hom	Verified	0.686168670397296	0.246303375812381	no	1170	0.260117218106868	876	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS|MITOCHONDRION		Putative transcriptional repressor with Zn(2)-Cys(6) finger; negatively regulates transcription in response to oleate levels, based on mutant phenotype and localization to oleate-responsive promoters; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress	negative regulation of transcription from RNA polymerase II promoter|cellular response to oleic acid	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity	mitochondrion|nucleus|cytoplasm
YNR056C	YNR056C	BIO5	hom	Verified	0.685510746789782	0.246510840725274	no	1171	0.239257416383415	806	NA	FT	KETONE METABOLISM|COFACTOR METABOLISM	PLASMA MEMBRANE		Putative transmembrane protein involved in the biotin biosynthesis pathway; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis	biotin biosynthetic process|vitamin transport	transmembrane transporter activity	integral to membrane|plasma membrane
YFL014W	YFL014W	HSP12	hom	Verified	0.685327324613714	0.246568696444265	no	1172	0.202027922344932	652	NA	FT	MEMBRANE ORGANIZATION|RESPONSE TO OXIDATIVE STRESS	NUCLEUS|PLASMA MEMBRANE		Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension	cellular response to oxidative stress|cell adhesion|plasma membrane organization|cellular response to osmotic stress|cellular response to heat	lipid binding	cytosol|endosome|nucleus|plasma membrane|cytoplasm
YER066W_p	YER066W	RRT13	hom	Uncharacterized	0.685186642245024	0.246613075939538	no	1173	0.213363197952876	754	NA					Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription	biological_process	molecular_function	cellular_component
YNL162W-A_p	YNL162W-A	YNL162W-A	hom	Uncharacterized	0.685159514051194	0.246621634259828	no	1174	0.236420018015326	796	NA	FT		NUCLEUS		Putative protein of unknown function; identified by homology	biological_process	molecular_function	nucleus|cytoplasm
YLR204W	YLR204W	QRI5	hom	Verified	0.684151704791738	0.246939687565475	no	1175	0.294292970526148	1025	NA	FF|FT	RNA PROCESSING	MITOCHONDRION		Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA	mRNA processing	molecular_function	mitochondrion|integral to mitochondrial inner membrane
YLR303W	YLR303W	MET17	hom	Verified	0.683812691171806	0.247046725780882	no	1176	0.250854275945472	890	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Methionine and cysteine synthase (O-acetyl homoserine-O-acetyl serine sulfhydrylase), required for sulfur amino acid synthesis	methionine metabolic process|cysteine biosynthetic process	O-acetylhomoserine aminocarboxypropyltransferase activity|cysteine synthase activity	plasma membrane|cytoplasm
YPL004C	YPL004C	LSP1	hom	Verified	0.68375098984747	0.247066209672606	no	1177	0.234215267566663	807	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION	MITOCHONDRION		Primary component of eisosomes, which are large immobile patch structures at the cell cortex associated with endocytosis, along with Pil1p and Sur7p; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; member of the BAR domain family	negative regulation of protein kinase activity|endocytosis|response to heat	lipid binding	mitochondrial outer membrane|eisosome|mitochondrion|plasma membrane|cytoplasm
YIL014W	YIL014W	MNT3	hom	Verified	0.683710352611511	0.247079042447534	no	1178	0.221988378038633	795	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Alpha-1,3-mannosyltransferase, adds the fourth and fifth alpha-1,3-linked mannose residues to O-linked glycans during protein O-glycosylation	protein O-linked glycosylation	alpha-1,3-mannosyltransferase activity	cellular_component
YPL240C	YPL240C	HSP82	hom	Verified	0.683660843666999	0.247094677288491	no	1179	0.263377636769862	949	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION			Hsp90 chaperone; redundant in function with Hsc82p; required for pheromone signaling, negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding, nucleotide addition; protein abundance increases in response to DNA replication stress; contains two acid-rich unstructured regions that promote solubility of chaperone-substrate complexes; HSP82 has a paralog, HSC82, that arose from the whole genome duplication	proteasome assembly|positive regulation of telomere maintenance via telomerase|box C/D snoRNP assembly|response to stress|protein refolding|protein targeting to mitochondrion|response to osmotic stress|'de novo' protein folding	unfolded protein binding|ATPase activity, coupled	cytoplasm
YLR047C	YLR047C	FRE8	hom	Verified	0.683412920984782	0.247172978812223	no	1180	0.277877717967023	971	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY			Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p	cellular metal ion homeostasis	oxidoreductase activity, oxidizing metal ions	integral to membrane|membrane
YIL099W	YIL099W	SGA1	hom	Verified	0.682815141966044	0.24736183016656	no	1181	0.241880469379616	807	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation	ascospore formation|glycogen catabolic process	glucan 1,4-alpha-glucosidase activity	fungal-type vacuole
YDR128W	YDR128W	MTC5	hom	Verified	0.682315250550404	0.247519815901503	no	1182	0.224621091773617	739	NA					Subunit of the SEA (Seh1-associated) complex; SEA is a coatomer-related complex that associates dynamically with the vacuole; has N-terminal WD-40 repeats and a C-terminal RING motif; mtc5 is synthetically sick with cdc13-1; relative distribution to vacuolar membrane punctae decreases upon DNA replication stress	biological_process	molecular_function	fungal-type vacuole membrane|Seh1-associated complex|extrinsic to fungal-type vacuolar membrane
YEL067C_p	YEL067C	YEL067C	hom	Uncharacterized	0.682210269653865	0.247553000923369	no	1183	0.253959210529697	851	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YBR180W	YBR180W	DTR1	hom	Verified	0.682020576303311	0.247612970031476	no	1184	0.243534440661868	796	NA	FT	CELL WALL ORG/BIOGENESIS			Putative dityrosine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for spore wall synthesis; expressed during sporulation	ascospore wall assembly|amine transport|transmembrane transport	amine transmembrane transporter activity	integral to membrane|prospore membrane
YGL071W	YGL071W	AFT1	hom	Verified	0.681820376261781	0.247676269110031	no	1185	0.341246367986206	1157	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|ION HOMEOSTASIS|ION HOMEOSTASIS|RESPONSE TO NUTRIENT LEVELS|CHROMOSOME SEGREGATION	NUCLEUS		Transcription factor involved in iron utilization and homeostasis; binds consensus site PyPuCACCCPu and activates transcription in response to changes in iron availability; in iron-replete conditions activity is negatively regulated by Grx3p, Grx4p, and Fra2p, which regulate Aft1p translocation from the nucleus to the cytoplasm; AFT1 has a paralog, AFT2, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress	positive regulation of transcription from RNA polymerase II promoter in response to iron ion starvation|meiotic chromosome segregation|positive regulation of iron ion transport|establishment of mitotic sister chromatid cohesion|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding	nucleus|cytoplasm
YPL036W	YPL036W	PMA2	hom	Verified	0.681689048846289	0.247717796793744	no	1186	0.220553744859713	724	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	MITOCHONDRION|PLASMA MEMBRANE		Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential	proton transport|regulation of pH	hydrogen-exporting ATPase activity, phosphorylative mechanism	mitochondrion|integral to membrane|plasma membrane
YOR283W	YOR283W	YOR283W	hom	Verified	0.681352456919131	0.247824249146593	no	1187	0.240749875385193	823	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Phosphatase with a broad substrate specificity and some similarity to GPM1/YKL152C, a phosphoglycerate mutase; YOR283W is not an essential gene	dephosphorylation	phosphatase activity	nucleus|cytoplasm
YBR293W	YBR293W	VBA2	hom	Verified	0.681282815509847	0.247846277357753	no	1188	0.2470563063778	871	NA					Permease of basic amino acids in the vacuolar membrane	basic amino acid transport|transmembrane transport	basic amino acid transmembrane transporter activity|drug transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane
YBR280C	YBR280C	SAF1	hom	Verified	0.681012881883526	0.247931669695054	no	1189	0.249242712772383	862	NA	FT	PROTEOLYSIS		UBIQUITIN LIGASE COMPLEX	F-Box protein involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence; interacts with Skp1	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity	SCF ubiquitin ligase complex
YLR341W	YLR341W	SPO77	hom	Verified	0.680617942208907	0.248056635442763	no	1190	0.252574241635389	851	NA	FT	CELL WALL ORG/BIOGENESIS			Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis	ascospore wall assembly|ascospore formation	molecular_function	intracellular
YGL165C_d	YGL165C	YGL165C	hom	Dubious	0.680597608690033	0.248063070229473	no	1191	0.236449835158623	788	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CUP2/YGL166W	Unknown	Unknown	Unknown
YGL042C_d	YGL042C	YGL042C	hom	Dubious	0.680539820723269	0.248081358413058	no	1192	0.248658613655431	873	NA					Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene DST1	Unknown	Unknown	Unknown
YJR100C	YJR100C	AIM25	hom	Verified	0.680412116345158	0.248121775625361	no	1193	0.229944353855336	772	NA	FT		MITOCHONDRION		Putative protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to murine NOR1; null mutant is viable and displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	mitochondrion
YMR165C	YMR165C	PAH1	hom	Verified	0.680398794365942	0.248125992106466	no	1194	0.251546999380392	877	NA	FT	LIPID METABOLISM|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Mg2+-dependent phosphatidate (PA) phosphatase; dephosphorylates PA to yield diacylglycerol; responsible for de novo lipid synthesis and formation of lipid droplets; phosphorylation by Pho80p-Pho85p decreases catalytic activity and alters Pah1p localization and abundance; phosphorylation by protein kinase A decreases catalytic efficiency; dephosphorylation by Nem1p-Spo7p anchors Pah1p to the membrane increasing substrate catalysis; homologous to mammalian lipins 1 and 2	plasmid maintenance|vacuole fusion, non-autophagic|lipid particle organization|aerobic respiration|phospholipid biosynthetic process	phosphatidate phosphatase activity	cytosol|nuclear membrane|vacuole|cytoplasm|extrinsic to membrane
YHL035C	YHL035C	VMR1	hom	Verified	0.680363775123464	0.248137076075309	no	1195	0.255988412074079	862	NA	FT	NUCLEOTIDE METABOLISM	MITOCHONDRION		Vacuolar membrane protein involved in multiple drug resistance and metal sensitivity; ATP-binding cassette (ABC) family member involved in drug transport; potential Cdc28p substrate; induced under respiratory conditions	transport|response to drug|response to metal ion|drug transport	ATPase activity, coupled to transmembrane movement of substances	fungal-type vacuole membrane|mitochondrion|integral to membrane|ribosome
YJR126C	YJR126C	VPS70	hom	Verified	0.680082993557276	0.248225956023395	no	1196	0.235323670388282	780	NA	FT	PROTEIN LOCALIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT			Protein of unknown function involved in vacuolar protein sorting	protein targeting to vacuole	molecular_function	cellular_component
YMR003W	YMR003W	AIM34	hom	Verified	0.679919259844387	0.248277792915903	no	1197	0.245180627876753	821	NA	FT		MITOCHONDRION		Protein of unknown function; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays reduced frequency of mitochondrial genome loss	biological_process	molecular_function	mitochondrion
YDL062W_d	YDL062W	YDL062W	hom	Dubious	0.679635570446325	0.248367620560012	no	1198	0.254407143668772	856	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YDL063C; YDL062W is not essential	Unknown	Unknown	Unknown
YOR384W	YOR384W	FRE5	hom	Verified	0.679344419602283	0.248459828812736	no	1199	0.267048484110005	887	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION|PLASMA MEMBRANE		Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	ferric-chelate reductase activity	mitochondrion|integral to membrane
YGL159W_p	YGL159W	YGL159W	hom	Uncharacterized	0.679065495539516	0.248548181918064	no	1200	0.263586913637306	934	NA					Putative protein of unknown function; deletion mutant has no detectable phenotype	biological_process	molecular_function	cellular_component
YPR196W_p	YPR196W	YPR196W	hom	Uncharacterized	0.679024183814126	0.248561269409044	no	1201	0.238624118134788	851	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Putative maltose-responsive transcription factor	regulation of transcription, DNA-dependent	sequence-specific DNA binding	cellular_component
YDL162C_d	YDL162C	YDL162C	hom	Dubious	0.678863714959671	0.24861210917758	no	1202	0.248283193330806	849	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps ENT1/YDL161W, a verified gene involved in endocytosis and actin cortical patch assembly	Unknown	Unknown	Unknown
YOL003C	YOL003C	PFA4	hom	Verified	0.678474988578278	0.248735288490855	no	1203	0.250261891472814	858	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases	protein palmitoylation	palmitoyltransferase activity	integral to membrane|endoplasmic reticulum
YLR254C	YLR254C	NDL1	hom	Verified	0.678249798927458	0.248806661276034	no	1204	0.241891732915285	805	NA	FT	CELL CYCLE|CELL DIVISION	NUCLEUS|CYTOSKELETON		Homolog of nuclear distribution factor NudE, NUDEL; interacts with Pac1p and regulates dynein targeting to microtubule plus ends	nuclear migration along microtubule	microtubule plus-end binding	cytoplasmic microtubule|nucleus|cytoplasm
YGR125W_p	YGR125W	YGR125W	hom	Uncharacterized	0.678125857854581	0.248845948459101	no	1205	0.247054202242639	880	NA					Putative protein of unknown function; deletion mutant has decreased rapamycin resistance but normal wormannin resistance; green fluorescent protein (GFP)-fusion protein localizes to the vacuole	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YBR184W_p	YBR184W	YBR184W	hom	Uncharacterized	0.678084547533809	0.248859043852248	no	1206	0.243912189327656	873	NA					Putative protein of unknown function; YBR184W is not an essential gene	biological_process	molecular_function	cellular_component
YGR066C_p	YGR066C	YGR066C	hom	Uncharacterized	0.677848368272047	0.248933919844386	no	1207	0.267720146711882	889	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YOL048C	YOL048C	RRT8	hom	Verified	0.677723934931072	0.248973373811053	no	1208	0.24230097714973	816	NA					Protein of unknown function; identified in a screen for mutants with increased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to lipid particles; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	integral to membrane|lipid particle
YLR173W_p	YLR173W	YLR173W	hom	Uncharacterized	0.677233212803465	0.249128999063347	no	1209	0.252319403382203	838	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YNL293W	YNL293W	MSB3	hom	Verified	0.677230189935758	0.24912995788138	no	1210	0.247777714837141	854	NA	FT	VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH		Rab GTPase-activating protein; regulates endocytosis via activation of Vps21p and Ypt7p; also acts on Ypt52p and Sec4p; also required for proper actin organization; localizes to the plasma membrane and sites of polarized growth, and a portion localizes to endosomes and vacuoles; similar to Msb4p; relocalizes from bud neck to cytoplasm upon DNA replication stress	actin filament organization|exocytosis	Rab GTPase activator activity	incipient cellular bud site|polarisome|cellular bud tip
YDR539W	YDR539W	FDC1	hom	Verified	0.677085313864744	0.249175913165996	no	1211	0.241770377885775	844	NA	FT	KETONE METABOLISM|COFACTOR METABOLISM	PLASMA MEMBRANE		Putative phenylacrylic acid decarboxylase; essential for the decarboxylation of aromatic carboxylic acids to the corresponding vinyl derivatives; homolog of E. coli UbiD; GFP-fusion protein localizes to the cytoplasm	cinnamic acid catabolic process	molecular_function	cytoplasm
YLR093C	YLR093C	NYV1	hom	Verified	0.676753831980105	0.249281077537782	no	1212	0.242051677917669	816	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION			v-SNARE component of the vacuolar SNARE complex involved in vesicle fusion; inhibits ATP-dependent Ca(2+) transport activity of Pmc1p in the vacuolar membrane	vesicle-mediated transport|vacuole fusion, non-autophagic|vesicle fusion	SNAP receptor activity	SNARE complex|fungal-type vacuole membrane
YDL057W_p	YDL057W	YDL057W	hom	Uncharacterized	0.676252157948252	0.249440281136768	no	1213	0.220453058834809	748	NA					Putative protein of unknown function; YDL057W is not an essential gene	biological_process	molecular_function	cellular_component
YIL090W	YIL090W	ICE2	hom	Verified	0.675826828627748	0.249575299461111	no	1214	0.259848569091395	907	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Integral ER membrane protein with type-III transmembrane domains; required for maintenance of ER zinc homeostasis; necessary for efficient targeting of Trm1p tRNA methyltransferase to inner nuclear membrane; mutations cause defects in cortical ER morphology in both the mother and daughter cells	endoplasmic reticulum inheritance	molecular_function	integral to endoplasmic reticulum membrane|integral to membrane|endoplasmic reticulum
YPR106W	YPR106W	ISR1	hom	Verified	0.675300571531387	0.249742410446319	no	1215	0.242779359760356	823	NA	FT	PROTEIN PHOSPHORYLATION			Predicted protein kinase, overexpression causes sensitivity to staurosporine, which is a potent inhibitor of protein kinase C	biological_process	protein kinase activity	cellular_component
YBR282W	YBR282W	MRPL27	hom	Verified	0.674418120497838	0.250022762789862	no	1216	0.248838566678112	875	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit; homolog of human Bcl-2 interacting protein BMRP	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YDR080W	YDR080W	VPS41	hom	Verified	0.674327611799623	0.250051526601142	no	1217	0.251592666366212	871	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|VACUOLAR PROTEIN PROCESSING			Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport	regulation of SNARE complex assembly|regulation of vacuole fusion, non-autophagic|piecemeal microautophagy of nucleus|vacuole organization|vesicle-mediated transport|protein transport|vacuole fusion, non-autophagic|vacuolar protein processing	Rab guanyl-nucleotide exchange factor activity|phosphatidylinositol binding	endosome|fungal-type vacuole membrane|HOPS complex
YJR110W	YJR110W	YMR1	hom	Verified	0.6741847481935	0.250096932459706	no	1218	0.249843089382181	880	NA	FT	LIPID METABOLISM			Phosphatidylinositol 3-phosphate (PI3P) phosphatase; involved in various protein sorting pathways, including CVT targeting and endosome to vacuole transport; has similarity to the conserved myotubularin dual specificity phosphatase family	phosphatidylinositol dephosphorylation	mRNA binding|phosphatidylinositol-3-phosphatase activity	cytoplasm
YGL237C	YGL237C	HAP2	hom	Verified	0.672964444997892	0.25048495548917	no	1219	0.238597603550131	802	NA	FT	TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding	carbon catabolite activation of transcription from RNA polymerase II promoter|regulation of cellular respiration	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	CCAAT-binding factor complex|nucleus
YJR108W	YJR108W	ABM1	hom	Verified	0.672785222426365	0.250541970218567	no	1220	0.235183346794757	821	NA	FT	CYTOSKELETON ORGANIZATION			Protein of unknown function, required for normal microtubule organization	microtubule cytoskeleton organization	molecular_function	cellular_component
YGR064W_d	YGR064W	YGR064W	hom	Dubious	0.6723724206985	0.250673317882009	no	1221	0.338272299275639	1128	NA	FF				Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SPT4/YGR063C	Unknown	Unknown	Unknown
YMR011W	YMR011W	HXT2	hom	Verified	0.671666279253253	0.250898086614236	no	1222	0.249038340368863	872	NA	FT		PLASMA MEMBRANE		High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose	glucose transport	pentose transmembrane transporter activity|mannose transmembrane transporter activity|fructose transmembrane transporter activity|glucose transmembrane transporter activity	integral to membrane|plasma membrane
YDR537C_d	YDR537C	YDR537C	hom	Dubious	0.671562785531636	0.250931038199687	no	1223	0.250714559336726	843	NA					Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W	Unknown	Unknown	Unknown
YBR064W_d	YBR064W	YBR064W	hom	Dubious	0.671333229367019	0.251004135247314	no	1224	0.232077213713542	811	NA					Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YBR063C	Unknown	Unknown	Unknown
YMR219W	YMR219W	ESC1	hom	Verified	0.670865597755331	0.251153076966315	no	1225	0.267103747735534	922	NA	FT	GENE SILENCING	NUCLEUS		Protein localized to the nuclear periphery, involved in telomeric silencing; interacts with PAD4-domain of Sir4p	chromatin silencing at telomere	molecular_function	nuclear periphery
YBL079W	YBL079W	NUP170	hom	Verified	0.670577098615008	0.251244987901061	no	1226	0.271033880722398	930	NA	FF|FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA LOCALIZATION|CHROMOSOME SEGREGATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication	nucleocytoplasmic transport|chromosome segregation|protein targeting to nuclear inner membrane|mitotic cell cycle spindle assembly checkpoint|nuclear pore complex assembly	structural constituent of nuclear pore	integral to membrane|nuclear pore|nuclear pore inner ring
YPR121W	YPR121W	THI22	hom	Verified	0.670486002945054	0.251274013131265	no	1227	0.221677195507001	736	NA					Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis	thiamine biosynthetic process	phosphomethylpyrimidine kinase activity|hydroxymethylpyrimidine kinase activity	cellular_component
YIL153W	YIL153W	RRD1	hom	Verified	0.670371143976524	0.251310612436061	no	1228	0.269642301250364	936	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RESPONSE TO DNA DAMAGE|CYTOSKELETON ORGANIZATION	NUCLEUS|CHROMOSOME		Peptidyl-prolyl cis/trans-isomerase; activator of the phosphotyrosyl phosphatase activity of PP2A; involved in G1 phase progression, microtubule dynamics, bud morphogenesis and DNA repair; required for rapid reduction of Sgs1p levels in response to rapamycin; subunit of the Tap42p-Sit4p-Rrd1p complex; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress	DNA repair|mitotic spindle organization in nucleus|G1/S transition of mitotic cell cycle|response to osmotic stress|regulation of transcription from RNA polymerase II promoter in response to stress	peptidyl-prolyl cis-trans isomerase activity|protein phosphatase type 2A regulator activity	nuclear chromatin|nucleus|cytoplasm
YGL162W	YGL162W	SUT1	hom	Verified	0.670161151454788	0.251377532914847	no	1229	0.245055393718029	828	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Transcription factor of the Zn2Cys6 family involved in sterol uptake; involved in induction of hypoxic gene expression; relocalizes from nucleus to cytoplasm upon DNA replication stress	positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II repressing transcription factor binding	nucleus
YPL018W	YPL018W	CTF19	hom	Verified	0.669335530668132	0.251640733284262	no	1230	0.286327106705657	966	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME	KINETOCHORE	Outer kinetochore protein, needed for accurate chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-P and fission yeast fta2	attachment of spindle microtubules to kinetochore|chromosome segregation|establishment of mitotic sister chromatid cohesion	molecular_function	COMA complex|condensed nuclear chromosome kinetochore|nucleus
YGR244C	YGR244C	LSC2	hom	Verified	0.668970940849332	0.251757007505189	no	1231	0.254364031240724	878	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Beta subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate	tricarboxylic acid cycle|succinyl-CoA metabolic process	succinate-CoA ligase (ADP-forming) activity	mitochondrion
YLR048W	YLR048W	RPS0B	hom	Verified	0.668881636757374	0.251785492503856	no	1232	0.221785042249782	760	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2	cytoplasmic translation|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA export from nucleus|ribosomal small subunit assembly|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit
YCL075W	YCL075W	YCL075W	hom	pseudogene	0.668433065479764	0.251928597375392	no	1233	0.230549502075135	805	NA	FT		NUCLEUS		Pseudogene: encodes fragment of Ty Pol protein	transposition, RNA-mediated	ribonuclease activity|peptidase activity|RNA binding|RNA-directed DNA polymerase activity|DNA-directed DNA polymerase activity	retrotransposon nucleocapsid
YJL182C_d	YJL182C	YJL182C	hom	Dubious	0.668386371906923	0.251943496198435	no	1234	0.251825136443393	880	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YJL181W	Unknown	Unknown	Unknown
YER181C_d	YER181C	YER181C	hom	Dubious	0.668123258582808	0.252027458175778	no	1235	0.244487247056808	849	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative data; extensively overlaps a Ty1 LTR; protein product is detected in highly purified mitochondria in high-throughput studies	Unknown	Unknown	Unknown
YDR171W	YDR171W	HSP42	hom	Verified	0.667907534730154	0.252096308732452	no	1236	0.2281857926121	767	NA	FT	CYTOSKELETON ORGANIZATION	CYTOSKELETON		Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress	cytoskeleton organization	unfolded protein binding	cytoskeleton|chaperonin-containing T-complex|cytoplasm
YBR108W	YBR108W	AIM3	hom	Verified	0.666149197601896	0.252657870516798	no	1237	0.247950920879342	848	NA	FT	CYTOSKELETON ORGANIZATION	CYTOSKELETON		Protein interacting with Rvs167p; null mutant is viable and displays elevated frequency of mitochondrial genome loss	actin cortical patch assembly	molecular_function	membrane raft|actin cortical patch
YDR237W	YDR237W	MRPL7	hom	Verified	0.665540495350856	0.252852425733257	no	1238	0.26780614174008	936	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YMR246W	YMR246W	FAA4	hom	Verified	0.665338774546308	0.252916917727614	no	1239	0.247285531459571	857	NA	FT	KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM			Long chain fatty acyl-CoA synthetase; activates imported fatty acids with a preference for C12:0-C16:0 chain lengths; functions in long chain fatty acid import; important for survival during stationary phase; localized to lipid particles; involved in sphingolipid-to-glycerolipid metabolism; forms cytoplasmic foci upon DNA replication stress; FAA4 has a paralog, FAA1, that arose from the whole genome duplication	long-chain fatty acid transport|long-chain fatty-acyl-CoA metabolic process	long-chain fatty acid-CoA ligase activity	lipid particle|cytoplasm
YPR201W	YPR201W	ARR3	hom	Verified	0.665132396525855	0.252982907634975	no	1240	0.237805747460656	834	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Plasma membrane metalloid/H+ antiporter; transports arsenite and antimonite; required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite	arsenite transport|antimonite transport	antiporter activity|arsenite transmembrane transporter activity|antimonite transmembrane transporter activity	integral to membrane|plasma membrane
YNL183C	YNL183C	NPR1	hom	Verified	0.665020091940553	0.25301882112361	no	1241	0.23541116926587	825	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION	GOLGI APPARATUS|PLASMA MEMBRANE		Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex	regulation of transmembrane transporter activity|regulation of nitrogen utilization|protein phosphorylation|negative regulation of endocytosis	protein serine/threonine kinase activity	Golgi apparatus|plasma membrane|cytoplasm
YDL225W	YDL225W	SHS1	hom	Verified	0.664870033775516	0.253066811883199	no	1242	0.224857918602271	764	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins; undergoes sumoylation and phosphorylation during mitosis; protein abundance increases in response to DNA replication stress	cytokinesis, actomyosin contractile ring assembly|G1 phase of mitotic cell cycle|barrier septum assembly|exit from mitosis|cell cycle cytokinesis|septin ring assembly|cellular bud neck septin ring organization	GTP binding	cellular bud neck septin ring|mating projection tip
YKR005C_p	YKR005C	YKR005C	hom	Uncharacterized	0.664509068091515	0.253182273512376	no	1243	0.244092219403895	867	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YPL041C_p	YPL041C	YPL041C	hom	Uncharacterized	0.664484816689495	0.253190031770221	no	1244	0.245595421349093	785	NA					Protein of unknown function involved in maintenance of proper telomere length	biological_process	molecular_function	cellular_component
YMR141C_d	YMR141C	YMR141C	hom	Dubious	0.664317819222104	0.253243459268233	no	1245	0.256711242183156	878	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGR282C	YGR282C	BGL2	hom	Verified	0.664249443544394	0.253265336408486	no	1246	0.254303401032083	882	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Endo-beta-1,3-glucanase, major protein of the cell wall, involved in cell wall maintenance	fungal-type cell wall organization	1,3-beta-glucanosyltransferase activity|glucan endo-1,3-beta-D-glucosidase activity	fungal-type cell wall
YOL063C	YOL063C	CRT10	hom	Verified	0.664128631383676	0.253303993292715	no	1247	0.240320051492694	809	NA	FT	TRANSCRIPTION FROM RNA POL II			Protein involved in transcriptional regulation of RNR2 and RNR3; expression of the gene is induced by DNA damage and null mutations confer increased resistance to hydroxyurea; N-terminal region has a leucine repeat and a WD40 repeat	regulation of transcription from RNA polymerase II promoter	molecular_function	cellular_component
YPR138C	YPR138C	MEP3	hom	Verified	0.663318201691499	0.253563390798323	no	1248	0.24402053544279	830	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Ammonium permease of high capacity and low affinity; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation ammonia permease	nitrogen utilization|ammonium transport	ammonium transmembrane transporter activity	integral to membrane|plasma membrane
YKR028W	YKR028W	SAP190	hom	Verified	0.663281923155528	0.253575005878292	no	1249	0.253102515989612	855	NA	FT	CELL CYCLE|RNA PROCESSING|SIGNALING			Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication	TOR signaling cascade|dephosphorylation|G1/S transition of mitotic cell cycle|tRNA wobble uridine modification	molecular_function	cytoplasm
YJR151W-A_p	YJR151W-A	YJR151W-A	hom	Uncharacterized	0.663051887863025	0.253648661394382	no	1250	0.248524683878014	812	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR; predicted to have a role in transcription based on computational guilt by association analysis	biological_process	molecular_function	cellular_component
YCR053W	YCR053W	THR4	hom	Verified	0.661817745620151	0.25404401594371	no	1251	0.229148564548148	754	NA	FT	VESICLE-MEDIATED TRANSPORT|KETONE METABOLISM|MEMBRANE ORGANIZATION|AMINO ACID METABOLISM	NUCLEUS		Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway	endocytosis|threonine metabolic process	threonine synthase activity	nucleus|cytoplasm
YDR124W_p	YDR124W	YDR124W	hom	Uncharacterized	0.661240090295576	0.254229177472157	no	1252	0.240888004153933	804	NA					Putative protein of unknown function; non-essential gene; expression is strongly induced by alpha factor	biological_process	molecular_function	cellular_component
YNL146C-A_p	YNL146C-A	YNL146C-A	hom	Uncharacterized	0.659682352619095	0.254728846901051	no	1253	0.241720215039259	819	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YHR001W-A	YHR001W-A	QCR10	hom	Verified	0.659573054120304	0.254763925448973	no	1254	0.232335959998746	799	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Subunit of the ubiqunol-cytochrome c oxidoreductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain	mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration	ubiquinol-cytochrome-c reductase activity	mitochondrion|mitochondrial respiratory chain complex III
YOR019W	YOR019W	YOR019W	hom	Verified	0.659277265387145	0.254858869345496	no	1255	0.246931207721032	828	NA	FT	CELL CYCLE			Protein of unknown function that may interact with ribosomes, based on co-purification experiments	mitochondrion degradation	molecular_function	ribosome
YNL253W	YNL253W	TEX1	hom	Verified	0.658845094225723	0.254997623314798	no	1256	0.241671466627199	803	NA	FT	RNA LOCALIZATION	NUCLEUS		Protein involved in mRNA export, component of the transcription export (TREX) complex	mRNA export from nucleus	molecular_function	transcription export complex
YFL041W	YFL041W	FET5	hom	Verified	0.657793881065494	0.255335293398032	no	1257	0.2307280375543	806	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS	PLASMA MEMBRANE		Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport	iron ion transport	ferroxidase activity	fungal-type vacuole membrane|integral to membrane
YOR352W	YOR352W	TFB6	hom	Verified	0.657452164752531	0.255445109629145	no	1258	0.252099603318723	881	NA	FT		NUCLEUS		Subunit of TFIIH complex; facilities dissociation of the Ssl2p helices from TFIIH; expression levels regulated by Arg5,6p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus	biological_process	molecular_function	nucleus|holo TFIIH complex|cytoplasm
YPL147W	YPL147W	PXA1	hom	Verified	0.657363765818851	0.255473522116874	no	1259	0.246558530392466	827	NA	FT	NUCLEOTIDE METABOLISM			Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter ABCD1 and ABCD2 and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder	fatty acid transport	ATPase activity, coupled to transmembrane movement of substances	integral to membrane|integral to peroxisomal membrane
YHL036W	YHL036W	MUP3	hom	Verified	0.657280088961194	0.255500418393355	no	1260	0.267657895778017	920	NA					Low affinity methionine permease, similar to Mup1p	amino acid transport	L-methionine transmembrane transporter activity	integral to membrane|membrane
YDR178W	YDR178W	SDH4	hom	Verified	0.65723508259857	0.255514885413283	no	1261	0.284779386827229	968	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain	mitochondrial electron transport, succinate to ubiquinone|cellular respiration|tricarboxylic acid cycle	succinate dehydrogenase (ubiquinone) activity	mitochondrial respiratory chain complex II|mitochondrion
YJL158C	YJL158C	CIS3	hom	Verified	0.656951183621756	0.255606152865517	no	1262	0.238268391801522	799	NA	FT	CELL WALL ORG/BIOGENESIS	ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family	fungal-type cell wall organization	structural constituent of cell wall	extracellular region|fungal-type cell wall|endoplasmic reticulum|plasma membrane|cellular bud tip
YPR028W	YPR028W	YOP1	hom	Verified	0.656843628864867	0.255640733867293	no	1263	0.25739036211778	896	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Membrane protein that interacts with Yip1p to mediate membrane traffic; interacts with Sey1p to maintain ER morphology; overexpression leads to cell death and accumulation of internal cell membranes; mutants have reduced phosphatidylserine transfer between the ER and mitochondria; forms ER foci upon DNA replication stress	vesicle-mediated transport|endoplasmic reticulum organization|endoplasmic reticulum inheritance|nuclear pore complex assembly	protein binding	integral to membrane|endoplasmic reticulum|endoplasmic reticulum tubular network
YKR046C	YKR046C	PET10	hom	Verified	0.65628005108464	0.255821975311625	no	1264	0.249259269699745	849	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY			Protein of unknown function that co-purifies with lipid particles; expression pattern suggests a role in respiratory growth; computational analysis of large-scale protein-protein interaction data suggests a role in ATP/ADP exchange	aerobic respiration	molecular_function	lipid particle
YDR415C_p	YDR415C	YDR415C	hom	Uncharacterized	0.656246902238777	0.255832637764486	no	1265	0.227965273764585	780	NA	FT	PROTEOLYSIS			Putative aminopeptidase	biological_process	molecular_function	cellular_component
YMR022W	YMR022W	UBC7	hom	Verified	0.656142194541977	0.255866318918469	no	1266	0.278124403105729	965	NA	FT	CHROMATIN ORGANIZATION|CELL WALL ORG/BIOGENESIS|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly	fungal-type cell wall organization|chromatin assembly or disassembly|ER-associated protein catabolic process	ubiquitin-protein ligase activity	endoplasmic reticulum membrane
YML086C	YML086C	ALO1	hom	Verified	0.655151484600602	0.256185113468971	no	1267	0.232782973694617	787	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		D-Arabinono-1,4-lactone oxidase, catalyzes the final step in biosynthesis of dehydro-D-arabinono-1,4-lactone, which is protective against oxidative stress	cellular response to oxidative stress|dehydro-D-arabinono-1,4-lactone biosynthetic process	D-arabinono-1,4-lactone oxidase activity	mitochondrial outer membrane|mitochondrion|integral to mitochondrial outer membrane
YJL189W	YJL189W	RPL39	hom	Verified	0.655099528199675	0.256201837918214	no	1268	0.252664041740284	860	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YDR153C	YDR153C	ENT5	hom	Verified	0.654414904280318	0.256422267351714	no	1269	0.238943280940175	809	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM		Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin	late endosome to vacuole transport via multivesicular body sorting pathway|early endosome to Golgi transport|Golgi to endosome transport	clathrin binding|phosphatidylinositol-3,5-bisphosphate binding	endosome|clathrin vesicle coat|cytoplasm
YKL030W_d	YKL030W	YKL030W	hom	Dubious	0.653071400231123	0.256855124521273	no	1270	0.244701214687217	800	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species; partially overlaps the verified gene MAE1	Unknown	Unknown	Unknown
YMR152W	YMR152W	YIM1	hom	Verified	0.651080643947774	0.257497215297696	no	1271	0.250801690360694	862	NA	FT	RESPONSE TO DNA DAMAGE|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Protein of unknown function; null mutant displays sensitivity to DNA damaging agents; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress	response to DNA damage stimulus	molecular_function	mitochondrion|lipid particle|cytoplasm
YIL005W	YIL005W	EPS1	hom	Verified	0.650602669014423	0.25765150350368	no	1272	0.250500335963106	865	NA	FT	PROTEIN LOCALIZATION|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		ER protein with chaperone and co-chaperone activity, involved in retention of resident ER proteins; has a role in recognizing proteins targeted for ER-associated degradation (ERAD), member of the protein disulfide isomerase family	protein retention in ER lumen|ER-associated protein catabolic process	unfolded protein binding|protein disulfide isomerase activity|chaperone binding	endoplasmic reticulum membrane
YDL094C_d	YDL094C	YDL094C	hom	Dubious	0.650432341107342	0.257706496200882	no	1273	0.234147023802009	824	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verfied gene PMT5/YDL093W; YDL094C is not essential	Unknown	Unknown	Unknown
YDL243C	YDL243C	AAD4	hom	Verified	0.650367751951685	0.257727351287564	no	1274	0.250737291654687	863	NA	FT	OXIDATION-REDUCTION PROCESS			Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin	cellular aldehyde metabolic process	aryl-alcohol dehydrogenase (NAD+) activity	cellular_component
YGR226C_d	YGR226C	YGR226C	hom	Dubious	0.650038631493558	0.257833634057885	no	1275	0.262652038718686	907	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; overlaps significantly with a verified ORF, AMA1/YGR225W	Unknown	Unknown	Unknown
YLR437C	YLR437C	DIF1	hom	Verified	0.649985176571704	0.257850898386545	no	1276	0.238678765585608	828	NA	FT		NUCLEUS		Protein that regulates the nuclear localization of ribonucleotide reductase Rnr2p and Rnr4p subunits; phosphorylated by Dun1p in response to DNA damage and degraded; N-terminal half has similarity to S. pombe Spd1 protein	biological_process	molecular_function	cytoplasm
YBR273C	YBR273C	UBX7	hom	Verified	0.649432450201479	0.258029447508732	no	1277	0.238506189079541	800	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p; UBX7 has a paralog, UBX6, that arose from the whole genome duplication	sporulation resulting in formation of a cellular spore|ubiquitin-dependent protein catabolic process	molecular_function	nuclear envelope|endoplasmic reticulum
YGR071C	YGR071C	ENV11	hom	Verified	0.648985141090987	0.258173990258475	no	1278	0.24259684579414	839	NA	FT	VACUOLAR PROTEIN PROCESSING	NUCLEUS		Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and fragmented vacuoles; deletion mutant has increased glycogen accumulation and displays elongated buds; green fluorescent protein (GFP)-fusion protein localizes to the nucleus	vacuole organization|vacuolar protein processing	molecular_function	nucleus
YPR038W_d	YPR038W	IRC16	hom	Dubious	0.648346544961466	0.258380417908592	no	1279	0.249203457584663	867	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene YPR037C; null mutant displays increased levels of spontaneous Rad52p foci	Unknown	Unknown	Unknown
YOR374W	YOR374W	ALD4	hom	Verified	0.647652885456058	0.258604741778092	no	1280	0.247897334089557	836	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed	NADPH regeneration|ethanol metabolic process|pyruvate metabolic process|acetate biosynthetic process	aldehyde dehydrogenase [NAD(P)+] activity|aldehyde dehydrogenase (NAD) activity	mitochondrial nucleoid|mitochondrion
YPR083W	YPR083W	MDM36	hom	Verified	0.647306896362288	0.258716669532474	no	1281	0.266873667851009	887	NA	FT	MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial protein required for normal mitochondrial morphology and inheritance; proposed involvement in the formation of Dnm1p and Num1p-containing cortical anchor complexes that promote mitochondrial fission	mitochondrial fission|mitochondrion organization	molecular_function	mitochondrion|cytoplasm
YPR021C	YPR021C	AGC1	hom	Verified	0.646523692166489	0.258970129325082	no	1282	0.267112265126311	968	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial amino acid transporter, acts both as a glutamate uniporter and as an aspartate-glutamate exchanger; involved in nitrogen metabolism and nitrogen compound biosynthesis	L-glutamate transport|aspartate transport|cellular nitrogen compound biosynthetic process	antiporter activity|L-aspartate transmembrane transporter activity|L-glutamate transmembrane transporter activity|uniporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YPL214C	YPL214C	THI6	hom	Verified	0.646414630162013	0.259005434051478	no	1283	0.227938487974169	799	NA					Bifunctional enzyme with thiamine-phosphate pyrophosphorylase and 4-methyl-5-beta-hydroxyethylthiazole kinase activities, required for thiamine biosynthesis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern	thiamine biosynthetic process	hydroxyethylthiazole kinase activity|thiamine-phosphate diphosphorylase activity	cytosol|cytoplasm
YIL125W	YIL125W	KGD1	hom	Verified	0.645871034265599	0.259181439915564	no	1284	0.273279649620158	934	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA	tricarboxylic acid cycle|2-oxoglutarate metabolic process	oxoglutarate dehydrogenase (succinyl-transferring) activity	mitochondrial nucleoid|mitochondrion|mitochondrial matrix|mitochondrial oxoglutarate dehydrogenase complex
YDR198C	YDR198C	RKM2	hom	Verified	0.645857332054936	0.259185877225743	no	1285	0.278284858084553	935	NA					Ribosomal protein lysine methyltransferase, responsible for trimethylation of the lysine residue at position 3 of Rpl12Ap and Rpl12Bp	peptidyl-lysine trimethylation|peptidyl-lysine monomethylation	protein-lysine N-methyltransferase activity	cellular_component
YJL102W	YJL102W	MEF2	hom	Verified	0.645588091235055	0.259273075869293	no	1286	0.276081545186705	924	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM	MITOCHONDRION		Mitochondrial elongation factor involved in translational elongation	translational elongation	translation elongation factor activity	mitochondrion
YFR039C_p	YFR039C	YFR039C	hom	Uncharacterized	0.645016970405174	0.259458094139669	no	1287	0.234557767918426	794	NA					Putative protein of unknown function; may be involved in response to high salt and changes in carbon source; deletion mutant has decreased spore survival in Drosophila feces	biological_process	molecular_function	cellular_component
YMR121C	YMR121C	RPL15B	hom	Verified	0.644991505734625	0.259466345171443	no	1288	0.230099061330307	789	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress	cytoplasmic translation	structural constituent of ribosome|RNA binding	cytosolic large ribosomal subunit
YDL183C	YDL183C	YDL183C	hom	Verified	0.644662277596084	0.259573033476315	no	1289	0.286298834646933	968	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene	potassium ion transport|proton transport	molecular_function	integral to mitochondrial inner membrane
YOL152W	YOL152W	FRE7	hom	Verified	0.64362665124409	0.259908781882644	no	1290	0.263975206527579	927	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY	PLASMA MEMBRANE		Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels	iron ion transport|copper ion import	ferric-chelate reductase activity	integral to membrane|plasma membrane
YNL133C	YNL133C	FYV6	hom	Verified	0.642970548671055	0.260121605141362	no	1291	0.294721579042473	1024	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Protein of unknown function, required for survival upon exposure to K1 killer toxin; proposed to regulate double-strand break repair via non-homologous end-joining	double-strand break repair via nonhomologous end joining	molecular_function	nucleus
YGR096W	YGR096W	TPC1	hom	Verified	0.642107455523328	0.260401707718784	no	1292	0.292037048536427	969	NA	FT		MITOCHONDRION		Mitochondrial membrane transporter that mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family	thiamine pyrophosphate transport	thiamine transmembrane transporter activity	integral to membrane|integral to mitochondrial inner membrane
YDR457W	YDR457W	TOM1	hom	Verified	0.641698129299465	0.260534602050852	no	1293	0.233489792456303	816	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|PROTEOLYSIS|RNA LOCALIZATION	NUCLEUS		E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones; interacts with Dia2p and is required for Dia2p degradation; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase	endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|mitosis|nucleocytoplasmic transport|nucleus organization|cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|regulation of cell size|protein ubiquitination	ubiquitin-protein ligase activity	integral to membrane|nucleolus|nucleus
YDR274C_d	YDR274C	YDR274C	hom	Dubious	0.640891534013629	0.260796578328993	no	1294	0.237505201272237	787	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR399C	YLR399C	BDF1	hom	Verified	0.639553719226796	0.26123138944586	no	1295	0.231290110800332	821	NA	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS|CHROMOSOME		Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf2p	DNA repair|snRNA transcription|regulation of chromatin silencing at telomere|regulation of transcription by chromatin organization|regulation of chromatin silencing at silent mating-type cassette|Unknown|chromatin remodeling|negative regulation of heterochromatin assembly	histone acetyl-lysine binding|chromatin binding|core promoter binding|TFIID-class transcription factor binding	nuclear chromatin|Swr1 complex
YGL007W_d	YGL007W	BRP1	hom	Dubious	0.638816564044172	0.261471135693056	no	1296	0.31348530843202	1078	NA	FF				Dubious ORF located in the upstream region of PMA1, deletion leads to polyamine resistance due to downregulation of PMA1	Unknown	Unknown	Unknown
YNL115C_p	YNL115C	YNL115C	hom	Uncharacterized	0.638529508790201	0.261564525719924	no	1297	0.249598003863161	853	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene	biological_process	molecular_function	integral to membrane|fungal-type vacuole
YOL059W	YOL059W	GPD2	hom	Verified	0.637506094530164	0.261897620712922	no	1298	0.296249235443157	1018	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		NAD-dependent glycerol 3-phosphate dehydrogenase, homolog of Gpd1p, expression is controlled by an oxygen-independent signaling pathway required to regulate metabolism under anoxic conditions; located in cytosol and mitochondria; constitutively active but is inactivated via phosphorylation by energy-stress responsive kinase SNF1	NADH oxidation|glycerol metabolic process	glycerol-3-phosphate dehydrogenase [NAD+] activity	cytosol|mitochondrion
YIL110W	YIL110W	HPM1	hom	Verified	0.636817399317585	0.262121895655256	no	1299	0.259714922079023	880	NA	FT		NUCLEUS		AdoMet-dependent methyltransferase involved in a novel 3-methylhistidine modification of ribosomal protein Rpl3p; seven beta-strand MTase family member; null mutant exhibits a weak vacuolar protein sorting defect and caspofungin resistance	peptidyl-histidine methylation, to form tele-methylhistidine	S-adenosylmethionine-dependent methyltransferase activity|protein-histidine N-methyltransferase activity	nucleus|cytoplasm
YNL225C	YNL225C	CNM67	hom	Verified	0.636545855085993	0.26221035161158	no	1300	0.291025983901983	1014	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION	NUCLEUS|CYTOSKELETON		Component of the spindle pole body outer plaque; required for spindle orientation and mitotic nuclear migration; CNM67 has a paralog, ADY3, that arose from the whole genome duplication	microtubule nucleation|mitotic spindle organization	structural constituent of cytoskeleton	outer plaque of spindle pole body|spindle pole body
YBR199W	YBR199W	KTR4	hom	Verified	0.636460034181802	0.26223831108497	no	1301	0.216722197854548	738	NA	FT	CARBOHYDRATE METABOLISM	GOLGI APPARATUS		Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family	protein N-linked glycosylation	mannosyltransferase activity	Golgi apparatus
YFR025C	YFR025C	HIS2	hom	Verified	0.636075130221195	0.262363727195772	no	1302	0.236113339573539	777	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Histidinolphosphatase, catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control	histidine biosynthetic process	histidinol-phosphatase activity	intracellular
YGR199W	YGR199W	PMT6	hom	Verified	0.635688961514612	0.262489586268758	no	1303	0.259073059505523	897	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein O-mannosyltransferase, transfers mannose from dolichyl phosphate-D-mannose to protein serine/threonine residues of secretory proteins; reaction is essential for cell wall rigidity; member of a family of mannosyltransferases	protein O-linked glycosylation|protein O-linked mannosylation	dolichyl-phosphate-mannose-protein mannosyltransferase activity	integral to membrane
YAL065C_p	YAL065C	YAL065C	hom	Uncharacterized	0.635541458784595	0.262537668120476	no	1304	0.249788120981545	862	NA					Putative protein of unknown function; has homology to FLO1; possible pseudogene	biological_process	molecular_function	cellular_component
YJR144W	YJR144W	MGM101	hom	Verified	0.634441305264965	0.262896430194177	no	1305	0.286326339196975	1002	NA	FT	RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION	MITOCHONDRION|CHROMOSOME		Protein with a role in mitochondrial DNA recombinational repair;also involved in interstrand cross-link repair; binds to and catalyzes the annealing of single-stranded mtDNA; oligomerizes to form rings and filaments; related to Rad52-type recombination proteins, with limited overall similarity but sharing conserved functionally important residues; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage	DNA repair|recombinational repair|DNA strand renaturation	molecular_function	mitochondrial nucleoid|mitochondrion
YKR045C_p	YKR045C	YKR045C	hom	Uncharacterized	0.634191346054531	0.262977977281423	no	1306	0.263781089002439	905	NA					Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YGR169C	YGR169C	PUS6	hom	Verified	0.634101931291615	0.263007151234369	no	1307	0.216499433264082	738	NA	FT	RNA PROCESSING	MITOCHONDRION		tRNA:pseudouridine synthase, catalyzes the conversion of uridine to pseudouridine at position 31 in cytoplasmic and mitochondrial tRNAs; mutation of Asp168 to Ala abolishes enzyme activity; not essential for viability	tRNA pseudouridine synthesis	pseudouridine synthase activity	mitochondrion|cytoplasm
YOR101W	YOR101W	RAS1	hom	Verified	0.632738843852111	0.263452099629135	no	1308	0.231518839092448	818	NA	FT	SIGNALING|NUCLEOTIDE METABOLISM	PLASMA MEMBRANE		GTPase involved in G-protein signaling in adenylate cyclase activation; plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes; relative distribution to the nucleus increases upon DNA replication stress	adenylate cyclase-activating G-protein coupled receptor signaling pathway|replicative cell aging|Ras protein signal transduction	GTPase activity	plasma membrane
YDR253C	YDR253C	MET32	hom	Verified	0.632429177251079	0.263553236669997	no	1309	0.286530527735909	1000	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CELL CYCLE|AMINO ACID METABOLISM	NUCLEUS		Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; MET32 has a paralog, MET31, that arose from the whole genome duplication	regulation of mitotic cell cycle|regulation of sulfur amino acid metabolic process|regulation of transcription from RNA polymerase II promoter	core promoter proximal region sequence-specific DNA binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity	nucleus|cytoplasm
YGR223C	YGR223C	HSV2	hom	Verified	0.632361490236617	0.263575345871713	no	1310	0.269190725074014	919	NA	FT	MEMBRANE ORGANIZATION|RESPONSE TO NUTRIENT LEVELS			Phosphatidylinositol 3,5-bisphosphate-binding protein, plays a role in micronucleophagy; belongs to the PROPPIN family of proteins; predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization	piecemeal microautophagy of nucleus	phosphatidylinositol binding	endosome|fungal-type vacuole|extrinsic to membrane|cytoplasm
YKR014C	YKR014C	YPT52	hom	Verified	0.63220418325789	0.263626732081694	no	1311	0.269378614382553	949	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|VACUOLAR TRANSPORT	ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Rab family GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; protein abundance increases in response to DNA replication stress	endocytosis|protein targeting to vacuole	GTPase activity	late endosome
YAL061W_p	YAL061W	BDH2	hom	Uncharacterized	0.631536410132962	0.263844925062055	no	1312	0.223344444075268	752	NA	FT	OXIDATION-REDUCTION PROCESS	NUCLEUS		Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3	biological_process	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	nucleus|cytoplasm
YLR342W	YLR342W	FKS1	hom	Verified	0.631394231431032	0.263891393436944	no	1313	0.265649990482323	931	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	MITOCHONDRION|PLASMA MEMBRANE|CYTOSKELETON		Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling	(1->3)-beta-D-glucan biosynthetic process|positive regulation of endocytosis|regulation of cell size	1,3-beta-D-glucan synthase activity	mitochondrion|1,3-beta-D-glucan synthase complex|integral to membrane|plasma membrane|cellular bud neck|cellular bud tip|actin cortical patch
YGL045W	YGL045W	RIM8	hom	Verified	0.631167750243021	0.263965423073509	no	1314	0.295811638301009	991	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family	meiosis|protein processing|invasive growth in response to glucose limitation|ubiquitin-dependent endocytosis	molecular_function	internal side of plasma membrane
YMR147W_p	YMR147W	YMR147W	hom	Uncharacterized	0.630687305690724	0.264122500447849	no	1315	0.238217973976406	795	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YJR146W_p	YJR146W	YJR146W	hom	Uncharacterized	0.63048991422471	0.264187049753627	no	1316	0.252639861758378	839	NA					Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps HMS2	biological_process	molecular_function	cellular_component
YDR089W	YDR089W	YDR089W	hom	Verified	0.630272290767448	0.264258224467101	no	1317	0.234611649455783	803	NA	FT	MEMBRANE ORGANIZATION			Protein of unknown function; deletion confers resistance to nickel; contains an SPX domain, which is found in proteins involved in phosphate homeostasis; relocalizes from vacuole to cytoplasm upon DNA replication stress	cellular membrane organization	molecular_function	integral to membrane|membrane
YLR331C_d	YLR331C	JIP3	hom	Dubious	0.628817281087749	0.264734342564434	no	1318	0.262709612652707	915	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2	Unknown	Unknown	Unknown
YJL101C	YJL101C	GSH1	hom	Verified	0.628027645388917	0.264992914969917	no	1319	0.249999679274407	833	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|RESPONSE TO OXIDATIVE STRESS			Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress	response to cadmium ion|response to hydrogen peroxide|glutathione biosynthetic process	glutamate-cysteine ligase activity	intracellular
YPR022C_p	YPR022C	YPR022C	hom	Uncharacterized	0.626217965861886	0.265585992379279	no	1320	0.276107888685337	933	NA	FT		NUCLEUS		Putative transcription factor, as suggested by computational analysis; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS	biological_process	sequence-specific DNA binding	nucleus|cytoplasm
YMR183C	YMR183C	SSO2	hom	Verified	0.624475405512484	0.266157708700786	no	1321	0.250572365970088	864	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p	Golgi to plasma membrane transport|ascospore-type prospore assembly|vesicle fusion	phosphatidic acid binding|SNAP receptor activity	endoplasmic reticulum|plasma membrane|prospore membrane|cytoplasm
YHR187W	YHR187W	IKI1	hom	Verified	0.624090631970244	0.26628403292103	no	1322	0.262721209475578	890	NA	FT	RNA PROCESSING	NUCLEUS		Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin	tRNA modification	tRNA binding|ATPase activity	Elongator holoenzyme complex|nucleus|cytoplasm
YCR016W_p	YCR016W	YCR016W	hom	Uncharacterized	0.624064658350121	0.266292561360728	no	1323	0.229740764627155	810	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus and nucleus; predicted to be involved in ribosome biogenesis	biological_process	molecular_function	nucleolus|nucleus
YEL028W_d	YEL028W	YEL028W	hom	Dubious	0.623320480891302	0.266536970780333	no	1324	0.285974682790175	989	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPR018W	YPR018W	RLF2	hom	Verified	0.622502999827834	0.26680558592606	no	1325	0.25789631964885	865	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1); chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription	DNA replication-dependent nucleosome assembly	histone binding	chromosome, centromeric region|nucleus|CAF-1 complex
YBR084C-A	YBR084C-A	RPL19A	hom	Verified	0.622411418807547	0.266835686945089	no	1326	0.253038905704812	872	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L19A; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19A has a paralog, RPL19B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YLR329W	YLR329W	REC102	hom	Verified	0.621742873563264	0.267055477603801	no	1327	0.283131350704097	970	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Protein involved in early stages of meiotic recombination; required for chromosome synapsis; forms a complex with Rec104p and Spo11p necessary during the initiation of recombination	meiotic DNA double-strand break formation|reciprocal meiotic recombination	molecular_function	condensed nuclear chromosome|nucleus
YDR272W	YDR272W	GLO2	hom	Verified	0.621690031057489	0.267072853981731	no	1328	0.274270198081381	940	NA	FT	KETONE METABOLISM|CARBOHYDRATE METABOLISM			Cytoplasmic glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate	cellular carbohydrate metabolic process|methylglyoxal catabolic process to D-lactate	hydroxyacylglutathione hydrolase activity	cytoplasm
YLR325C	YLR325C	RPL38	hom	Verified	0.621195955562015	0.267235350096756	no	1329	0.285176663510924	955	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L38; homologous to mammalian ribosomal protein L38, no bacterial homolog	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YNL119W	YNL119W	NCS2	hom	Verified	0.619734335419303	0.267716353189502	no	1330	0.255707629167485	899	NA	FT	RNA PROCESSING			Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae	tRNA wobble position uridine thiolation|pseudohyphal growth|protein urmylation|invasive growth in response to glucose limitation	molecular_function	cytosol|cytoplasm
YDR414C	YDR414C	ERD1	hom	Verified	0.619630272328165	0.267750615836378	no	1331	0.283970156508532	987	NA	FT	PROTEIN LOCALIZATION|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p)	protein retention in ER lumen|protein glycosylation	molecular_function	integral to membrane|membrane
YFR016C	YFR016C	YFR016C	hom	Verified	0.619622815414891	0.267753071100886	no	1332	0.227451426978315	771	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and bud; interacts with Spa2p; YFL016C is not an essential gene	biological_process	molecular_function	cellular bud|cytoplasm
YDL067C	YDL067C	COX9	hom	Verified	0.61925150538063	0.267875343049488	no	1333	0.273568667714947	927	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YDL018C	YDL018C	ERP3	hom	Verified	0.618429989849282	0.268145967036978	no	1334	0.282498494598541	938	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport	vesicle-mediated transport	molecular_function	integral to membrane
YDL019C	YDL019C	OSH2	hom	Verified	0.617753867928381	0.268368798575845	no	1335	0.29615627464363	964	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability	endocytosis|maintenance of cell polarity|sterol transport|exocytosis	lipid binding|oxysterol binding|sterol transporter activity|1-phosphatidylinositol binding	endoplasmic reticulum|plasma membrane|cortical endoplasmic reticulum|cellular bud neck
YFR045W_p	YFR045W	YFR045W	hom	Uncharacterized	0.617230982178627	0.26854119144596	no	1336	0.243742126177204	855	NA	FT		MITOCHONDRION		Putative mitochondrial transport protein; null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white	transport	transporter activity	integral to membrane|mitochondrial inner membrane
YLR401C	YLR401C	DUS3	hom	Verified	0.617030380792791	0.268607343511205	no	1337	0.212125065547565	704	NA	FT	RNA PROCESSING|OXIDATION-REDUCTION PROCESS	NUCLEUS		Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress	tRNA modification	tRNA dihydrouridine synthase activity	nucleus|cytoplasm
YKL162C-A_d	YKL162C-A	YKL162C-A	hom	Dubious	0.617002033408243	0.26861669225272	no	1338	0.259450494118136	908	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGL232W	YGL232W	TAN1	hom	Verified	0.615841719733575	0.268999494727232	no	1339	0.275266976116843	918	NA	FT	RNA PROCESSING	NUCLEUS		Putative tRNA acetyltransferase; RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA; protein abundance increases in response to DNA replication stress	tRNA modification	RNA binding	nucleus|cytoplasm
YKL202W_d	YKL202W	YKL202W	hom	Dubious	0.61396577559676	0.26961897163047	no	1340	0.235150038878744	815	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YHR049W	YHR049W	FSH1	hom	Verified	0.612314763539256	0.270164761827774	no	1341	0.239165957659262	835	NA	FT		NUCLEUS		Putative serine hydrolase that localizes to both the nucleus and cytoplasm; sequence is similar to S. cerevisiae Fsh2p and Fsh3p and the human candidate tumor suppressor OVCA2	biological_process	hydrolase activity	nucleus|cytoplasm
YHR050W-A_p	YHR050W-A	YHR050W-A	hom	Uncharacterized	0.610389108497882	0.27080204063341	no	1342	0.272210102793366	930	NA					Protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YNR032C-A	YNR032C-A	HUB1	hom	Verified	0.610189231595677	0.270868231118198	no	1343	0.246623328841748	863	NA	FT	RNA PROCESSING			Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear	cellular protein modification process|cell morphogenesis involved in conjugation with cellular fusion|mRNA splicing, via spliceosome	protein tag	mating projection
YDR374C_p	YDR374C	YDR374C	hom	Uncharacterized	0.610044642436554	0.270916117753991	no	1344	0.248218514131667	855	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YDL169C	YDL169C	UGX2	hom	Verified	0.609885265174612	0.270968906971293	no	1345	0.272003573791618	925	NA					Protein of unknown function, transcript accumulates in response to any combination of stress conditions	biological_process	molecular_function	cellular_component
YJL149W	YJL149W	DAS1	hom	Verified	0.609623517242891	0.271055614715717	no	1346	0.282423184585873	991	NA	FT	PROTEOLYSIS		UBIQUITIN LIGASE COMPLEX	Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity|protein binding, bridging	SCF ubiquitin ligase complex
YML007C-A_p	YML007C-A	YML007C-A	hom	Uncharacterized	0.608417007664308	0.271455467089236	no	1347	0.289708483748103	1047	NA	FF|FT		MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria	biological_process	molecular_function	mitochondrion
YOL019W-A_p	YOL019W-A	YOL019W-A	hom	Uncharacterized	0.608409008528029	0.271458119083324	no	1348	0.259371924213682	873	NA					Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YGL219C	YGL219C	MDM34	hom	Verified	0.607640868643574	0.271712844494514	no	1349	0.311765292194965	1052	NA	FT	MITOCHONDRION ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION		Mitochondrial component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth	mitochondrion organization|phospholipid transport	molecular_function	mitochondrial outer membrane|ERMES complex|mitochondrion|cytoplasm
YDR490C	YDR490C	PKH1	hom	Verified	0.606595921668559	0.272059553728647	no	1350	0.257801181718616	894	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION			Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh2p	regulation of nuclear-transcribed mRNA poly(A) tail shortening|endocytosis|protein phosphorylation|MAPK cascade involved in cell wall biogenesis|cytoplasmic mRNA processing body assembly	protein kinase activity	cytosol|cell cortex|eisosome
YJL130C	YJL130C	URA2	hom	Verified	0.606095630068631	0.272225626319743	no	1351	0.246368291053039	807	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM	MITOCHONDRION		Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP	glutamine metabolic process|'de novo' pyrimidine nucleobase biosynthetic process|negative regulation of pyrimidine nucleobase metabolic process	aspartate carbamoyltransferase activity|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	mitochondrion|integral to membrane|cytoplasm
YFL001W	YFL001W	DEG1	hom	Verified	0.604193016126927	0.272857661794658	no	1352	0.299015943780281	993	NA	FT	RNA PROCESSING	NUCLEUS		tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm; non-essential for viability	tRNA pseudouridine synthesis	pseudouridine synthase activity	nucleus|cytoplasm
YPR117W_p	YPR117W	YPR117W	hom	Uncharacterized	0.603824713600474	0.272980093429587	no	1353	0.271671753496271	909	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YPL205C_d	YPL205C	YPL205C	hom	Dubious	0.603263050928255	0.273166854535535	no	1354	0.249171584764196	874	NA					Hypothetical protein; deletion of locus affects telomere length	Unknown	Unknown	Unknown
YBR111W-A	YBR111W-A	SUS1	hom	Verified	0.603097584749161	0.273221886546648	no	1355	0.336912361567286	1115	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE|HISTONE ACETYLTRANSFERASE	Component of both the SAGA histone acetylase and TREX-2 complexes; interacts with RNA polymerase II; involved in mRNA export coupled transcription activation and elongation; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP	poly(A)+ mRNA export from nucleus|regulation of protein localization|nuclear retention of pre-mRNA at the site of transcription|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|histone deubiquitination|histone H3-K4 methylation|transcription elongation from RNA polymerase II promoter|histone H3-K79 methylation|positive regulation of transcription from RNA polymerase II promoter	enzyme activator activity	DUBm complex|nucleoplasm|transcription export complex 2|SAGA complex|nuclear pore
YBL042C	YBL042C	FUI1	hom	Verified	0.602876855435484	0.273295306944546	no	1356	0.310589609034621	1115	NA	FF|FT		PLASMA MEMBRANE		High affinity uridine permease, localizes to the plasma membrane; also mediates low but significant transport of the cytotoxic nucleoside analog 5-fluorouridine; not involved in uracil transport; relative distribution to the vacuole increases upon DNA replication stress	uridine transport|transmembrane transport	uridine transmembrane transporter activity	integral to membrane|plasma membrane
YJL073W	YJL073W	JEM1	hom	Verified	0.602266074904327	0.273498519595029	no	1357	0.279977365378817	980	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		DnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane; exhibits genetic interactions with KAR2	karyogamy involved in conjugation with cellular fusion|ER-associated protein catabolic process|protein folding in endoplasmic reticulum	unfolded protein binding|chaperone binding	endoplasmic reticulum|nuclear outer membrane-endoplasmic reticulum membrane network
YKR074W	YKR074W	AIM29	hom	Verified	0.60202376655432	0.273579158667416	no	1358	0.258758104329712	896	NA					Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YKR074W is not an essential gene; null mutant displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	cytoplasm
YDL053C	YDL053C	PBP4	hom	Verified	0.601735364164727	0.27367515295161	no	1359	0.280372467889718	973	NA	FT		NUCLEUS		Pbp1p binding protein; interacts strongly with Pab1p-binding protein 1 (Pbp1p) in the yeast two-hybrid system; also interacts with Lsm12p in a copurification assay; relative distribution to the nucleus increases upon DNA replication stress	biological_process	molecular_function	nucleus|cytoplasmic stress granule|cytoplasm
YIR026C	YIR026C	YVH1	hom	Verified	0.600594172136237	0.274055160275917	no	1360	0.278650246698887	947	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RIBOSOME BIOGENESIS|SIGNALING|CELL WALL ORG/BIOGENESIS	NUCLEUS		Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases	meiosis|ascospore wall assembly|ribosomal large subunit assembly|cAMP-mediated signaling|protein dephosphorylation	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	nucleus|preribosome, large subunit precursor|cytoplasm
YPL213W	YPL213W	LEA1	hom	Verified	0.599329172332817	0.274476699008642	no	1361	0.275225763893386	981	NA	FT	RNA PROCESSING	NUCLEUS		Component of U2 snRNP; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; putative homolog of human U2A' snRNP protein	mRNA splicing, via spliceosome	molecular_function	U2 snRNP|U2-type prespliceosome|cytoplasm
YLR119W	YLR119W	SRN2	hom	Verified	0.597931031725719	0.274942976489811	no	1362	0.282108624377033	964	NA	FT	PROTEIN LOCALIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT			Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus	protein targeting to membrane|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein targeting to vacuole	protein binding	endosome|ESCRT I complex
YDL215C	YDL215C	GDH2	hom	Verified	0.59648410977803	0.275425933070128	no	1363	0.262679117211582	862	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		NAD(+)-dependent glutamate dehydrogenase, degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels	nitrogen compound metabolic process	glutamate dehydrogenase (NAD+) activity	mitochondrion
YER085C_p	YER085C	YER085C	hom	Uncharacterized	0.595663722261507	0.27569994898873	no	1364	0.255752532732552	880	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YDL197C	YDL197C	ASF2	hom	Verified	0.595605943741181	0.275719252521525	no	1365	0.254829668068152	861	NA	FT	GENE SILENCING	NUCLEUS|CHROMOSOME		Anti-silencing protein that causes derepression of silent loci when overexpressed	chromatin silencing at silent mating-type cassette	molecular_function	nuclear chromosome, telomeric region|nucleus
YDR443C	YDR443C	SSN2	hom	Verified	0.593399224375305	0.276457003924987	no	1366	0.281711677966664	948	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation	negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter by galactose	RNA polymerase II transcription coactivator activity|RNA polymerase II transcription factor recruiting transcription factor activity	mediator complex
YHL006C	YHL006C	SHU1	hom	Verified	0.593035811415546	0.276578593078723	no	1367	0.224157750079445	787	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function	recombinational repair|maintenance of rDNA	molecular_function	nucleolus|Shu complex
YOR114W_p	YOR114W	YOR114W	hom	Uncharacterized	0.592163494410121	0.276870556103882	no	1368	0.283240134217897	976	NA					Putative protein of unknown function; null mutant is viable	biological_process	molecular_function	cellular_component
YDR152W	YDR152W	GIR2	hom	Verified	0.590315028625131	0.277489732815178	no	1369	0.282496993287963	956	NA	FT	TRANSLATION			Highly-acidic cytoplasmic RWD domain-containing protein of unknown function; forms a complex with Rbg2p; interacts with Rbg1p and Gcn1p; associates with translating ribosomes; putative intrinsically unstructured protein	cytoplasmic translation	molecular_function	polysome|cytoplasm
YNL303W_d	YNL303W	YNL303W	hom	Dubious	0.590020859266307	0.277588332495095	no	1370	0.263874233700875	894	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YBR260C	YBR260C	RGD1	hom	Verified	0.588491304737497	0.278101284279082	no	1371	0.257527486069065	859	NA	FT	SIGNALING	SITE OF POLARIZED GROWTH|CYTOSKELETON		GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization	response to acid|osmosensory signaling pathway	Rho GTPase activator activity|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding	cellular bud|mating projection tip|actin cortical patch
YGL248W	YGL248W	PDE1	hom	Verified	0.588029857798896	0.278256125974734	no	1372	0.265331913713046	905	NA	FT	SIGNALING|NUCLEOTIDE METABOLISM			Low-affinity cyclic AMP phosphodiesterase, controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation	cAMP-mediated signaling	3',5'-cyclic-AMP phosphodiesterase activity	cellular_component
YJL013C	YJL013C	MAD3	hom	Verified	0.587698538321187	0.27836732842379	no	1373	0.260203032909368	899	NA	FT	CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS		Subunit of the spindle-assembly checkpoint complex, which delays anaphase onset in cells with defects in mitotic spindle assembly; pseudosubstrate inhibitor of APC(Cdc20), the anaphase promoting complex involved in securin (Pds1p) turnover	distributive segregation|mitotic cell cycle spindle assembly checkpoint|mitotic cell cycle G2/M transition decatenation checkpoint	molecular_function	mitotic checkpoint complex
YJL170C	YJL170C	ASG7	hom	Verified	0.587693920637942	0.278368878433437	no	1374	0.287061256348935	968	NA	FT		ENDOMEMBRANE SYSTEM|PLASMA MEMBRANE		Protein that regulates signaling from a G protein beta subunit Ste4p and its relocalization within the cell; specific to a-cells and induced by alpha-factor	conjugation with cellular fusion	molecular_function	plasma membrane
YIL030C	YIL030C	SSM4	hom	Verified	0.587263235067453	0.278513464393651	no	1375	0.289537248134307	1006	NA	FT	PROTEOLYSIS	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM	UBIQUITIN LIGASE COMPLEX	Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation	ER-associated protein catabolic process	ubiquitin-protein ligase activity	nuclear envelope|integral to endoplasmic reticulum membrane|Doa10p ubiquitin ligase complex|integral to membrane|nuclear inner membrane
YJR075W	YJR075W	HOC1	hom	Verified	0.586880827882936	0.278641873414766	no	1376	0.26799523481862	940	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	GOLGI APPARATUS		Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele	cell wall mannoprotein biosynthetic process|substituted mannan metabolic process	alpha-1,6-mannosyltransferase activity|transferase activity, transferring glycosyl groups	alpha-1,6-mannosyltransferase complex
YFR053C	YFR053C	HXK1	hom	Verified	0.586302206165552	0.278836224371481	no	1377	0.299532928727943	1034	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Hexokinase isoenzyme 1; a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves hexokinase Hxk2p; HXK1 has a paralog, HXK2, that arose from the whole genome duplication	mannose metabolic process|glucose import|glycolysis|fructose import|glucose metabolic process|fructose metabolic process	hexokinase activity	cytosol|mitochondrion|cytoplasm
YIL023C	YIL023C	YKE4	hom	Verified	0.585110329920068	0.279236766733213	no	1378	0.250087472106439	824	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Zinc transporter; localizes to the ER; null mutant is sensitive to calcofluor white, leads to zinc accumulation in cytosol; ortholog of the mouse KE4 and member of the ZIP (ZRT, IRT-like Protein) family	zinc ion transport	zinc ion transmembrane transporter activity	integral to membrane|endoplasmic reticulum
YMR082C_d	YMR082C	YMR082C	hom	Dubious	0.585035511310093	0.279261919627123	no	1379	0.29658976756337	984	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDL075W	YDL075W	RPL31A	hom	Verified	0.584373447122218	0.279484543638878	no	1380	0.306672724359924	1051	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L31A; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31A has a paralog, RPL31B, that arose from the whole genome duplication	cytoplasmic translation|regulation of translational fidelity	structural constituent of ribosome	cytosolic large ribosomal subunit
YBL015W	YBL015W	ACH1	hom	Verified	0.583512503028995	0.279774171342412	no	1381	0.262074543640652	880	NA	FT	KETONE METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth	acetate metabolic process	acetate CoA-transferase activity|acetyl-CoA hydrolase activity	cytosol|mitochondrion
YIL050W	YIL050W	PCL7	hom	Verified	0.583343364810561	0.279831087748424	no	1382	0.222917300318207	760	NA	FT	CELL CYCLE|OXIDATION-REDUCTION PROCESS|CELL DIVISION|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Pho85p cyclin of the Pho80p subfamily, forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism, expression is cell-cycle regulated	regulation of glycogen catabolic process|regulation of cyclin-dependent protein kinase activity|regulation of protein stability|regulation of glycogen biosynthetic process	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex|nucleus
YGL262W_p	YGL262W	YGL262W	hom	Uncharacterized	0.583332476919386	0.279834751806042	no	1383	0.256484520912464	877	NA					Putative protein of unknown function; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein; YGL262W is not an essential gene	biological_process	molecular_function	cellular_component
YPL234C	YPL234C	VMA11	hom	Verified	0.582523669031299	0.280107001680356	no	1384	0.291755046029692	970	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Vacuolar ATPase V0 domain subunit c', involved in proton transport activity; hydrophobic integral membrane protein (proteolipid) containing four transmembrane segments; N and C termini are in the vacuolar lumen	vacuolar acidification	proton-transporting ATPase activity, rotational mechanism	vacuolar proton-transporting V-type ATPase, V0 domain|integral to membrane|fungal-type vacuole
YLR187W	YLR187W	SKG3	hom	Verified	0.580924670885862	0.280645612056039	no	1385	0.28047451114624	917	NA	FT		SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate; similar to Skg4p; relocalizes from bud neck to cytoplasm upon DNA replication stress; SKG3 has a paralog, CAF120, that arose from the whole genome duplication	biological_process	molecular_function	cellular bud|cellular bud neck|cytoplasm
YDL025C	YDL025C	RTK1	hom	Verified	0.580726216260729	0.280712494924197	no	1386	0.32019756842086	1102	NA	FT	PROTEIN PHOSPHORYLATION			Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance increases in response to DNA replication stress	biological_process	protein serine/threonine kinase activity|protein kinase activity	cellular_component
YJL100W	YJL100W	LSB6	hom	Verified	0.576974848414544	0.281978223163733	no	1387	0.299799542647999	1022	NA	FT	LIPID METABOLISM	PLASMA MEMBRANE		Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization	phosphatidylinositol phosphorylation	1-phosphatidylinositol 4-kinase activity	fungal-type vacuole membrane|plasma membrane|cytoplasm
YEL046C	YEL046C	GLY1	hom	Verified	0.576705409586614	0.282069238732623	no	1388	0.316881998595896	1052	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Threonine aldolase, catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis	threonine catabolic process|glycine biosynthetic process	threonine aldolase activity|L-allo-threonine aldolase activity	cytosol
YLR263W	YLR263W	RED1	hom	Verified	0.576334821295904	0.282194445368451	no	1389	0.255207719441844	844	NA	FT	CELL CYCLE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Protein component of the synaptonemal complex axial elements, involved in chromosome segregation during the first meiotic division; critical for coupling checkpoint signaling to SC formation; interacts with Hop1p, Mec3p and Ddc1p	synaptonemal complex assembly|meiotic recombination checkpoint|positive regulation of catalytic activity	chromatin DNA binding|structural molecule activity	lateral element
YBR026C	YBR026C	ETR1	hom	Verified	0.575384279309538	0.282515716902067	no	1390	0.311698797093125	1028	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family; localized to in mitochondria, where it has a probable role in fatty acid synthesis	fatty acid biosynthetic process|aerobic respiration	enoyl-[acyl-carrier-protein] reductase activity	mitochondrion
YOR220W	YOR220W	RCN2	hom	Verified	0.574630218865479	0.282770705112888	no	1391	0.275752282847677	977	NA					Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; phosphorylated in response to alpha factor; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	cytoplasm
YDL077C	YDL077C	VAM6	hom	Verified	0.572409015410306	0.283522454779307	no	1392	0.329107641497918	1099	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION			Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p	regulation of SNARE complex assembly|regulation of vacuole fusion, non-autophagic|piecemeal microautophagy of nucleus|vesicle-mediated transport|vacuole organization|vacuole fusion, non-autophagic	Rab guanyl-nucleotide exchange factor activity|phosphatidylinositol binding	fungal-type vacuole membrane|HOPS complex|fungal-type vacuole
YBL087C	YBL087C	RPL23A	hom	Verified	0.572404053420949	0.283524135199012	no	1393	0.304117808261332	1000	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L23A; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23A has a paralog, RPL23B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YGL115W	YGL115W	SNF4	hom	Verified	0.572160445743193	0.283606640870126	no	1394	0.290891767052144	992	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|PLASMA MEMBRANE		Activating gamma subunit of the AMP-activated Snf1p kinase complex; additional subunits of the complex are Snf1p and a Sip1p/Sip2p/Gal83p family member; activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis; protein abundance increases in response to DNA replication stress	positive regulation of gluconeogenesis|peroxisome organization|protein phosphorylation|replicative cell aging|regulation of transcription from RNA polymerase II promoter	AMP-activated protein kinase activity|protein serine/threonine kinase activator activity	AMP-activated protein kinase complex|plasma membrane|nucleus|nuclear envelope lumen|cytoplasm
YHR009C_p	YHR009C	TDA3	hom	Uncharacterized	0.570472778927678	0.284178539824505	no	1395	0.290511549103301	1002	NA	FT	VESICLE-MEDIATED TRANSPORT|OXIDATION-REDUCTION PROCESS			Putative oxidoreductase involved in late endosome to Golgi transport; physical and genetical interactions with Btn2p; null mutant is viable, has extended S phase, and sensitive to expression of top1-T722A allele; similar to human FOXRED1	retrograde transport, endosome to Golgi	molecular_function	late endosome|cytoplasm
YDL080C	YDL080C	THI3	hom	Verified	0.569700270204995	0.284440503389051	no	1396	0.274037343783138	921	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Probable alpha-ketoisocaproate decarboxylase, may have a role in catabolism of amino acids to long-chain and complex alcohols; required for expression of enzymes involved in thiamine biosynthesis	regulation of thiamine biosynthetic process|branched-chain amino acid catabolic process to alcohol via Ehrlich pathway|positive regulation of transcription from RNA polymerase II promoter|leucine catabolic process	carboxy-lyase activity	cytosol|nucleus
YOL097W-A_p	YOL097W-A	YOL097W-A	hom	Uncharacterized	0.5695312852184	0.284497822854268	no	1397	0.288416135052806	972	NA					Putative protein of unknown function; identified by expression profiling and mass spectrometry	biological_process	molecular_function	cellular_component
YMR085W_p	YMR085W	YMR085W	hom	Uncharacterized	0.567656217251076	0.285134213200926	no	1398	0.297390646303814	1048	NA	FT	CARBOHYDRATE METABOLISM			Putative protein of unknown function; YMR085W and adjacent ORF YMR084W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1	biological_process	molecular_function	cellular_component
YLL051C	YLL051C	FRE6	hom	Verified	0.566974088364626	0.285365893137492	no	1399	0.255710446432257	873	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY			Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels	intracellular sequestering of iron ion|copper ion import	ferric-chelate reductase activity	fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YPR004C	YPR004C	AIM45	hom	Verified	0.566806233925009	0.285422917375837	no	1400	0.284517378790503	972	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-alpha; interacts with frataxin, Yfh1p; null mutant displays elevated frequency of mitochondrial genome loss; may have a role in oxidative stress response	biological_process	molecular_function	mitochondrion
YBR077C	YBR077C	SLM4	hom	Verified	0.565830837874312	0.285754390486494	no	1401	0.315615634978194	1050	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|SIGNALING			Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4	signal transduction|microautophagy	phosphatidylinositol-3,4-bisphosphate binding	fungal-type vacuole membrane|EGO complex|late endosome membrane|cytoplasm
YBR118W	YBR118W	TEF2	hom	Verified	0.565756087021273	0.285779800948257	no	1402	0.266013829802712	897	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM|RNA LOCALIZATION	CYTOSKELETON	RIBOSOME	Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus; TEF2 has a paralog, TEF1, that arose from the whole genome duplication	translational elongation|tRNA export from nucleus	GDP binding|GTP binding|translation elongation factor activity	ribosome|eukaryotic translation elongation factor 1 complex|cytoplasm
YDR117C	YDR117C	TMA64	hom	Verified	0.565535603184747	0.285854757470562	no	1403	0.264469195357409	897	NA	FT	TRANSLATION			Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; in mammals the corresponding protein, eIF2D, has been shown to possess translation initiation factor activity	biological_process	RNA binding	ribosome
YOR005C	YOR005C	DNL4	hom	Verified	0.565335440353885	0.285922813681193	no	1404	0.266625302333368	934	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION	NUCLEUS|CHROMOSOME		DNA ligase required for nonhomologous end-joining (NHEJ), forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth	double-strand break repair via nonhomologous end joining|replicative cell aging	DNA ligase (ATP) activity	DNA ligase IV complex|nuclear chromatin
YDL037C	YDL037C	BSC1	hom	Verified	0.564645391441655	0.286157492265272	no	1405	0.283357892081822	985	NA					Protein of unconfirmed function, similar to cell surface flocculin Flo11p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression	biological_process	molecular_function	cellular_component
YBR299W	YBR299W	MAL32	hom	Verified	0.563589569658884	0.286516743460839	no	1406	0.289210907969436	1012	NA	FT	CARBOHYDRATE METABOLISM			Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose	sucrose catabolic process|maltose catabolic process	sucrose alpha-glucosidase activity|alpha-glucosidase activity|maltose alpha-glucosidase activity	plasma membrane
YDR169C	YDR169C	STB3	hom	Verified	0.563172212945931	0.286658811164508	no	1407	0.26953998727075	928	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress	positive regulation of transcription from RNA polymerase II promoter by glucose	sequence-specific DNA binding	nucleus|cytoplasm
YDR226W	YDR226W	ADK1	hom	Verified	0.562931506613346	0.286740762485145	no	1408	0.291922399554979	1032	NA	FT	NUCLEOTIDE METABOLISM	MITOCHONDRION		Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence; protein abundance increases in response to DNA replication stress	ADP biosynthetic process|DNA replication initiation|nucleotide metabolic process	adenylate kinase activity	mitochondrion|mitochondrial intermembrane space|cytoplasm
YPL067C_p	YPL067C	YPL067C	hom	Uncharacterized	0.561484205114675	0.287233747430437	no	1409	0.273823046059951	918	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL067C is not an essential gene	biological_process	molecular_function	cytoplasm
YJL210W	YJL210W	PEX2	hom	Verified	0.561123490561441	0.287356677713778	no	1410	0.278517460282847	938	NA	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION			RING-finger peroxin and E3 ubiquitin ligase, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import	protein import into peroxisome matrix	ubiquitin-protein ligase activity|protein binding	peroxisomal membrane
YJR115W_p	YJR115W	YJR115W	hom	Uncharacterized	0.559597352038753	0.287877055719773	no	1411	0.267962789573219	917	NA					Putative protein of unknown function; YJR115W has a paralog, ECM13, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YOR296W_p	YOR296W	YOR296W	hom	Uncharacterized	0.558756535000402	0.288163944926881	no	1412	0.253581424356714	864	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; expressed during copper starvation; YOR296W is not an essential gene	biological_process	molecular_function	cytoplasm
YGR153W_p	YGR153W	YGR153W	hom	Uncharacterized	0.55867107708772	0.288193110963811	no	1413	0.281547140014317	969	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YDR175C	YDR175C	RSM24	hom	Verified	0.558421072884473	0.288278443203259	no	1414	0.295779844464657	999	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YFR047C	YFR047C	BNA6	hom	Verified	0.55823151676579	0.288343151049257	no	1415	0.284545940183257	958	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	NUCLEUS		Quinolinate phosphoribosyl transferase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p	de novo NAD biosynthetic process from tryptophan	nicotinate-nucleotide diphosphorylase (carboxylating) activity	nucleus|cytoplasm
YCL009C	YCL009C	ILV6	hom	Verified	0.557773835850521	0.288499415570017	no	1416	0.278896133295815	922	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Regulatory subunit of acetolactate synthase, which catalyzes the first step of branched-chain amino acid biosynthesis; enhances activity of the Ilv2p catalytic subunit, localizes to mitochondria	branched-chain amino acid biosynthetic process	enzyme regulator activity|acetolactate synthase activity	mitochondrial nucleoid|acetolactate synthase complex|mitochondrion
YDR179C	YDR179C	CSN9	hom	Verified	0.556605605137472	0.288898461653411	no	1417	0.286568479662082	955	NA	FT	SIGNALING	NUCLEUS		Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|cullin deneddylation	molecular_function	signalosome
YJR048W	YJR048W	CYC1	hom	Verified	0.556321472902527	0.288995555245008	no	1418	0.2594007710737	863	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; CYC1 has a paralog, CYC7, that arose from the whole genome duplication	mitochondrial electron transport, cytochrome c to oxygen|mitochondrial electron transport, ubiquinol to cytochrome c	electron carrier activity	mitochondrion|mitochondrial intermembrane space
YDL095W	YDL095W	PMT1	hom	Verified	0.556014639168834	0.289100423623707	no	1419	0.315257238593507	1089	NA	FT	PROTEIN LOCALIZATION|CARBOHYDRATE METABOLISM|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein O-mannosyltransferase of the ER membrane; transfers mannose from dolichyl phosphate-D-mannose to protein serine and threonine residues; 1 of 7 related proteins involved in O-glycosylation which is essential for cell wall rigidity; involved in ER quality control; amino terminus faces cytoplasm, carboxyl terminus faces ER lumen	ER-associated misfolded protein catabolic process|Unknown|protein exit from endoplasmic reticulum|protein O-linked mannosylation	dolichyl-phosphate-mannose-protein mannosyltransferase activity	integral to membrane|dolichyl-phosphate-mannose-protein mannosyltransferase complex
YMR132C_p	YMR132C	JLP2	hom	Uncharacterized	0.555342551528195	0.289330189498033	no	1420	0.262786526900248	874	NA					Protein of unknown function, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein)	biological_process	molecular_function	cytoplasm
YLR269C_d	YLR269C	YLR269C	hom	Dubious	0.554680616252609	0.289556568434495	no	1421	0.277110976500541	940	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOR289W_p	YOR289W	YOR289W	hom	Uncharacterized	0.554100960776708	0.289754876320718	no	1422	0.278133161262193	924	NA	FT		NUCLEUS		Putative protein of unknown function; transcription induced by the unfolded protein response; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	biological_process	molecular_function	nucleus|cytoplasm
YGR117C_p	YGR117C	YGR117C	hom	Uncharacterized	0.553694538967821	0.289893956648203	no	1423	0.25601076467284	899	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YIL072W	YIL072W	HOP1	hom	Verified	0.553263655989444	0.290041441938958	no	1424	0.314113110294595	1050	NA	FT	CELL CYCLE	NUCLEUS|CHROMOSOME		Meiosis-specific protein required for chromosome synapsis; displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex; required for chiasma formation; in vitro, displays the ability to promote intra- and intermolecular synapsis between double-stranded DNA molecules and to fold DNA into rigid protein?DNA filaments	synaptonemal complex assembly|meiotic recombination checkpoint|synapsis	four-way junction DNA binding	condensed nuclear chromosome|lateral element
YPL215W	YPL215W	CBP3	hom	Verified	0.552213252012889	0.290401128016548	no	1425	0.263690174232303	926	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex	positive regulation of mitochondrial translation|mitochondrial respiratory chain complex III assembly	ribosome binding	integral to mitochondrial membrane|mitochondrion|mitochondrial ribosome
YDR462W	YDR462W	MRPL28	hom	Verified	0.548485041168224	0.291679448921478	no	1426	0.293981463930769	1020	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YOL096C	YOL096C	COQ3	hom	Verified	0.548454781350318	0.291689835064705	no	1427	0.290257489862621	1034	NA	FT	KETONE METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein	ubiquinone biosynthetic process	hexaprenyldihydroxybenzoate methyltransferase activity	mitochondrion|mitochondrial inner membrane|extrinsic to membrane
YHL014C	YHL014C	YLF2	hom	Verified	0.547213791460325	0.292115931143413	no	1428	0.292353564716647	1027	NA	FT		MITOCHONDRION		Protein of unknown function, has weak similarity to E. coli GTP-binding protein gtp1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	GTP binding	mitochondrion
YKR094C	YKR094C	RPL40B	hom	Verified	0.546161348616528	0.292477516106663	no	1429	0.283122316481065	972	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RESPONSE TO DNA DAMAGE|TRANSLATION	NUCLEUS|MITOCHONDRION	RIBOSOME	Ubiquitin-ribosomal 60S subunit protein L40B fusion protein; cleaved to yield ubiquitin and ribosomal protein L40B; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40B has a paralog, RPL40A, that arose from the whole genome duplication	cytoplasmic translation|protein ubiquitination|ribosome biogenesis	structural constituent of ribosome|protein tag	mitochondrion|cytosolic large ribosomal subunit
YNL104C	YNL104C	LEU4	hom	Verified	0.545508778367691	0.292701822353281	no	1430	0.266802160849809	903	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway; LEU4 has a paralog, LEU9, that arose from the whole genome duplication	leucine biosynthetic process	2-isopropylmalate synthase activity	mitochondrion|cytoplasm
YKL106C-A_p	YKL106C-A	YKL106C-A	hom	Uncharacterized	0.545438615018135	0.292725944172154	no	1431	0.26920095761586	914	NA					Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi	biological_process	molecular_function	cellular_component
YML041C	YML041C	VPS71	hom	Verified	0.545225435092584	0.292799240058514	no	1432	0.315906747918684	1074	NA	FF|FT	PROTEIN LOCALIZATION|CHROMATIN ORGANIZATION|VACUOLAR TRANSPORT	NUCLEUS|CHROMOSOME		Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting	chromatin remodeling|protein targeting to vacuole|histone exchange	nucleosome binding	Swr1 complex|nucleus
YPR027C_p	YPR027C	YPR027C	hom	Uncharacterized	0.544805221488895	0.29294374356445	no	1433	0.306256689901942	1085	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YJL044C	YJL044C	GYP6	hom	Verified	0.544684052466283	0.292985417444655	no	1434	0.291222092100872	981	NA	FT	PROTEIN LOCALIZATION|SIGNALING|NUCLEOTIDE METABOLISM			GTPase-activating protein (GAP) for the yeast Rab family member, Ypt6p; involved in vesicle mediated protein transport	intracellular protein transport	GTPase activator activity	endosome|clathrin-coated vesicle
YLR134W	YLR134W	PDC5	hom	Verified	0.544017415044339	0.293214744436243	no	1435	0.289032034867414	968	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Minor isoform of pyruvate decarboxylase, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde, regulation is glucose- and ethanol-dependent, repressed by thiamine, involved in amino acid catabolism	L-phenylalanine catabolic process|glucose catabolic process to ethanol|pyruvate metabolic process|tryptophan catabolic process|aromatic amino acid family catabolic process to alcohol via Ehrlich pathway	pyruvate decarboxylase activity	nucleus|cytoplasm
YLR461W	YLR461W	PAU4	hom	Verified	0.543941738203535	0.293240782950421	no	1436	0.298252288598206	1023	NA					Member of the seripauperin multigene family encoded mainly in subtelomeric regions; active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme	biological_process	molecular_function	cellular_component
YBR249C	YBR249C	ARO4	hom	Verified	0.541047285020073	0.294237495648452	no	1437	0.29091660046799	999	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan; relative distribution to the nucleus increases upon DNA replication stress	aromatic amino acid family biosynthetic process	3-deoxy-7-phosphoheptulonate synthase activity	nucleus|cytoplasm
YBR094W	YBR094W	PBY1	hom	Verified	0.539687071606162	0.294706428674632	no	1438	0.279501511261924	939	NA					Putative tubulin tyrosine ligase associated with P-bodies; forms cytoplasmic foci upon DNA replication stress	nuclear-transcribed mRNA catabolic process|biological_process	molecular_function	cytoplasmic mRNA processing body|cytoplasm
YCR024C-A	YCR024C-A	PMP1	hom	Verified	0.539475556717798	0.294779379300792	no	1439	0.316961904814585	1053	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Regulatory subunit for the plasma membrane H(+)-ATPase Pma1p; small single-membrane span proteolipid; forms unique helix and positively charged cytoplasmic domain that is able to specifically segregate phosphatidylserines; PMP1 has a paralog, PMP2, that arose from the whole genome duplication	cation transport	enzyme regulator activity	plasma membrane|membrane
YER045C	YER045C	ACA1	hom	Verified	0.537815327507892	0.295352274544467	no	1440	0.286388761690611	993	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		ATF/CREB family basic leucine zipper (bZIP) transcription factor; binds as a homodimer to the ATF/CREB consensus sequence TGACGTCA; important for carbon source utilization; target genes include GRE2 and COS8; ACA1 has a paralog, CST6, that arose from the whole genome duplication	positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YDL065C	YDL065C	PEX19	hom	Verified	0.537809495388264	0.295354287936501	no	1441	0.294996430500709	1003	NA	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Chaperone and import receptor for newly-synthesized class I PMPs; binds peroxisomal membrane proteins (PMPs) in the cytoplasm and delivers them to the peroxisome for subsequent insertion into the peroxisomal membrane; interacts with Myo2p and contributes to peroxisome partitioning	protein stabilization|protein import into peroxisome membrane|peroxisome inheritance|ER-dependent peroxisome organization|protein exit from endoplasmic reticulum	peroxisome membrane targeting sequence binding|protein binding	cytosol|peroxisomal membrane|endoplasmic reticulum
YMR230W	YMR230W	RPS10B	hom	Verified	0.537308517042022	0.295527261625437	no	1442	0.307848139986408	1058	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10B has a paralog, RPS10A, that arose from the whole genome duplication	cytoplasmic translation|rRNA export from nucleus	structural constituent of ribosome	cytosolic small ribosomal subunit
YCL005W-A	YCL005W-A	VMA9	hom	Verified	0.536596687903185	0.295773116227382	no	1443	0.325417084523072	1099	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS			Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex; essential for vacuolar acidification; interacts with the V-ATPase assembly factor Vma21p in the ER; involved in V0 biogenesis	cell wall mannoprotein biosynthetic process|vacuolar acidification|protein complex assembly|transmembrane transport	ATPase activity, coupled to transmembrane movement of ions	vacuolar proton-transporting V-type ATPase, V0 domain|fungal-type vacuole membrane
YGL152C_d	YGL152C	YGL152C	hom	Dubious	0.536349620195667	0.295858471494647	no	1444	0.309804610665774	1052	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PEX14/YGL153W	Unknown	Unknown	Unknown
YDR130C	YDR130C	FIN1	hom	Verified	0.53626935805258	0.295886202347058	no	1445	0.301862935653881	1015	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME|CYTOSKELETON	KINETOCHORE	Spindle pole body-related intermediate filament protein; forms cell cycle-specific filaments between spindle pole bodies in dividing cells; localizes to poles and microtubules of spindle during anaphase and contributes to spindle stability; involved in Glc7p localization and regulation; relative distribution to the nucleus increases upon DNA replication stress	intermediate filament cytoskeleton organization|mitotic cell cycle spindle checkpoint|mitotic spindle stabilization|mitotic sister chromatid segregation	microtubule binding|structural constituent of cytoskeleton	spindle microtubule|condensed nuclear chromosome kinetochore|intermediate filament|nucleus|spindle pole body|astral microtubule|spindle
YOR024W_d	YOR024W	YOR024W	hom	Dubious	0.535042659476441	0.296310179469612	no	1446	0.299072048294001	1022	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YNL275W	YNL275W	BOR1	hom	Verified	0.534833181944245	0.296382607882435	no	1447	0.288614465394047	966	NA	FT	PROTEIN LOCALIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT	PLASMA MEMBRANE		Boron efflux transporter of the plasma membrane; binds HCO3-, I-, Br-, NO3- and Cl-; has similarity to the characterized boron efflux transporter A. thaliana BOR1	borate transport|protein targeting to vacuole	borate efflux transmembrane transporter activity	integral to membrane|plasma membrane|fungal-type vacuole
YNL243W	YNL243W	SLA2	hom	Verified	0.532800952787655	0.297085687113233	no	1448	0.299519851820374	983	NA	FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON		Adaptor protein that links actin to clathrin and endocytosis; involved in membrane cytoskeleton assembly and cell polarization; present in the actin cortical patch of the emerging bud tip; dimer in vivo	bipolar cellular bud site selection|fungal-type cell wall organization|actin filament organization|endocytosis|exocytosis	protein binding, bridging	incipient cellular bud site|mating projection tip|actin cortical patch
YGR077C	YGR077C	PEX8	hom	Verified	0.531537315954349	0.297523244839705	no	1449	0.225365689332562	759	NA	FT	PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION			Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p	protein targeting to peroxisome|peroxisome organization	peroxisome targeting sequence binding	peroxisomal matrix|peroxisomal membrane|extrinsic to intraperoxisomal membrane
YDR109C_p	YDR109C	YDR109C	hom	Uncharacterized	0.530843172129385	0.297763730170801	no	1450	0.28565591794067	983	NA	FT	CARBOHYDRATE METABOLISM			Putative kinase	biological_process	molecular_function	cellular_component
YKL128C	YKL128C	PMU1	hom	Verified	0.530061941713349	0.298034492554737	no	1451	0.263638903319582	898	NA	FT		NUCLEUS		Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant	biological_process	molecular_function	nucleus|cytoplasm
YLR091W	YLR091W	GEP5	hom	Verified	0.529563988005455	0.298207134140556	no	1452	0.321441501159434	1078	NA	FT	MITOCHONDRION ORGANIZATION	MITOCHONDRION		Protein of unknown function, required for mitochondrial genome maintenance; detected in highly purified mitochondria in high-throughput studies; null mutant has decreased levels of cardiolipin and phosphatidylethanolamine	mitochondrial genome maintenance	molecular_function	mitochondrion
YLR062C_d	YLR062C	BUD28	hom	Dubious	0.529030114112519	0.298392279904794	no	1453	0.317739566452367	1099	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene RPL22A; diploid mutant displays a weak budding pattern phenotype in a systematic assay	Unknown	Unknown	Unknown
YLR237W	YLR237W	THI7	hom	Verified	0.528967758861937	0.298413907918587	no	1454	0.317383061885987	1059	NA	FT		PLASMA MEMBRANE		Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia	thiamine transport	thiamine transmembrane transporter activity	integral to membrane|plasma membrane
YOR180C	YOR180C	DCI1	hom	Verified	0.528337529721516	0.298632543889593	no	1455	0.328992666813034	1116	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS			Peroxisomal protein; identification as a delta(3,5)-delta(2,4)-dienoyl-CoA isomerase involved in fatty acid metabolism is disputed	fatty acid beta-oxidation	dodecenoyl-CoA delta-isomerase activity	peroxisomal matrix
YGR072W	YGR072W	UPF3	hom	Verified	0.527786450023351	0.2988237814002	no	1456	0.289789807306356	967	NA	FT		NUCLEUS		Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance	nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|translational frameshifting|protein ubiquitination	molecular_function	nucleolus|nucleus|polysome|cytoplasm
YLR046C_p	YLR046C	YLR046C	hom	Uncharacterized	0.527156493234263	0.299042459242369	no	1457	0.283261158261472	975	NA					Putative membrane protein; member of the fungal lipid-translocating exporter (LTE) family of proteins; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance	biological_process	molecular_function	integral to membrane
YIL038C	YIL038C	NOT3	hom	Verified	0.527005909482369	0.299094742363649	no	1458	0.292533638814315	1011	NA	FT	TRANSCRIPTION FROM RNA POL II|RNA PROCESSING	NUCLEUS		Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation	regulation of transcription from RNA polymerase II promoter|nuclear-transcribed mRNA poly(A) tail shortening|positive regulation of transcription elongation from RNA polymerase II promoter|protein ubiquitination	ubiquitin-protein ligase activity	CCR4-NOT core complex|cytoplasm
YNL160W	YNL160W	YGP1	hom	Verified	0.525569907309634	0.299593534867867	no	1459	0.30032999374045	1012	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS			Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p	cell wall assembly	molecular_function	extracellular region
YPR073C	YPR073C	LTP1	hom	Verified	0.52353018679678	0.30030267491815	no	1460	0.284077618302894	972	NA	FT		NUCLEUS		Protein phosphotyrosine phosphatase of unknown cellular role; activated by adenine	protein dephosphorylation	protein tyrosine phosphatase activity	nucleus|cytoplasm
YNL059C	YNL059C	ARP5	hom	Verified	0.523488824133417	0.300317063126239	no	1461	0.315697196176119	1078	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes	nucleosome mobilization|chromatin remodeling	ATP-dependent 3'-5' DNA helicase activity	nucleus|Ino80 complex
YEL060C	YEL060C	PRB1	hom	Verified	0.523125468342715	0.300443471632026	no	1462	0.277343700940876	946	NA	FT	PROTEOLYSIS|RESPONSE TO NUTRIENT LEVELS			Vacuolar proteinase B (yscB); serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; activity inhibited by Pbi2p; protein abundance increases in response to DNA replication stress	vacuolar protein catabolic process|sporulation resulting in formation of a cellular spore|cellular response to starvation	serine-type endopeptidase activity	fungal-type vacuole lumen|fungal-type vacuole
YOR245C	YOR245C	DGA1	hom	Verified	0.519757202608979	0.301616405960644	no	1463	0.297126726898546	985	NA	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Diacylglycerol acyltransferase, catalyzes the terminal step of triacylglycerol (TAG) formation, acylates diacylglycerol using acyl-CoA as an acyl donor, localized to lipid particles	lipid storage|triglyceride biosynthetic process	diacylglycerol O-acyltransferase activity	integral to membrane|lipid particle
YLR296W_d	YLR296W	YLR296W	hom	Dubious	0.5196757736818	0.301644787514817	no	1464	0.302159759226621	1030	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR210W	YMR210W	YMR210W	hom	Verified	0.518525848927761	0.302045714924764	no	1465	0.26945596228091	905	NA	FT	KETONE METABOLISM|LIPID METABOLISM			Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification	medium-chain fatty acid biosynthetic process	transferase activity, transferring acyl groups	cellular_component
YMR062C	YMR062C	ARG7	hom	Verified	0.518053558969857	0.302210450640334	no	1466	0.348806841707285	1170	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS	MITOCHONDRION		Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine	fungal-type cell wall organization|ornithine biosynthetic process|arginine biosynthetic process	acetyl-CoA:L-glutamate N-acetyltransferase activity|glutamate N-acetyltransferase activity	mitochondrion|mitochondrial matrix
YER086W	YER086W	ILV1	hom	Verified	0.517985650904057	0.302234140429727	no	1467	0.33711432629958	1120	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation	threonine catabolic process|isoleucine biosynthetic process	L-threonine ammonia-lyase activity	mitochondrion
YFL042C_p	YFL042C	YFL042C	hom	Uncharacterized	0.516626915670151	0.302708311462885	no	1468	0.308356468567089	1035	NA					Putative protein of unknown function; YFL042C is not an essential gene	biological_process	molecular_function	cellular_component
YPR135W	YPR135W	CTF4	hom	Verified	0.516623960757498	0.302709343030536	no	1469	0.37102746972154	1232	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Chromatin-associated protein, required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion	DNA repair|replicative cell aging|double-strand break repair via break-induced replication|DNA replication initiation|DNA-dependent DNA replication|mitotic sister chromatid cohesion	chromatin binding|DNA binding	nuclear chromosome|replication fork protection complex|nuclear replication fork|nucleus
YDR326C	YDR326C	YSP2	hom	Verified	0.516244458218446	0.302841841434972	no	1470	0.308445358000859	1071	NA	FT		MITOCHONDRION		Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification; YSP2 has a paralog, YHR080C, that arose from the whole genome duplication	apoptotic process	molecular_function	mitochondrion
YGR212W	YGR212W	SLI1	hom	Verified	0.515689042445699	0.303035804467515	no	1471	0.313408995467536	1060	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE		N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin	response to drug	N-acetyltransferase activity	nuclear envelope|plasma membrane
YDR385W	YDR385W	EFT2	hom	Verified	0.515372638950709	0.303146324160465	no	1472	0.295486506580838	1005	NA	FT	TRANSLATION|NUCLEOTIDE METABOLISM		RIBOSOME	Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT2 has a paralog, EFT1, that arose from the whole genome duplication	translational elongation|positive regulation of translational elongation	translation elongation factor activity	ribosome
YPR151C	YPR151C	SUE1	hom	Verified	0.515336118188738	0.30315908201749	no	1473	0.277801422282791	947	NA	FT	PROTEOLYSIS	MITOCHONDRION		Mitochondrial protein required for degradation of unstable forms of cytochrome c	protein catabolic process	molecular_function	mitochondrial envelope
YER144C	YER144C	UBP5	hom	Verified	0.515086567639961	0.303246264340791	no	1474	0.305373429188642	1050	NA	FT	PROTEOLYSIS	SITE OF POLARIZED GROWTH		Putative ubiquitin-specific protease, closest paralog of Doa4p but has no functional overlap; concentrates at the bud neck	protein deubiquitination	ubiquitin-specific protease activity	incipient cellular bud site|cellular bud neck
YMR027W_p	YMR027W	YMR027W	hom	Uncharacterized	0.514947687343962	0.303294788049975	no	1475	0.307314616337915	1057	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR027W is not an essential gene	biological_process	molecular_function	nucleus|cytoplasm
YDR360W_d	YDR360W	OPI7	hom	Dubious	0.51446704304021	0.303462748263506	no	1476	0.303035159178642	1019	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene VID21/YDR359C.	Unknown	Unknown	Unknown
YPL058C	YPL058C	PDR12	hom	Verified	0.51165031577673	0.304447882156677	no	1477	0.305873293539399	1039	NA	FT	KETONE METABOLISM|NUCLEOTIDE METABOLISM	PLASMA MEMBRANE		Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity	propionate metabolic process|transport|organic acid transport	xenobiotic-transporting ATPase activity|organic acid transmembrane transporter activity	integral to membrane|plasma membrane
YNL218W	YNL218W	MGS1	hom	Verified	0.510634880121266	0.304803373562458	no	1478	0.268642861799373	909	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress	regulation of DNA repair|DNA replication, Okazaki fragment processing|DNA strand renaturation	ubiquitin binding|single-stranded DNA-dependent ATPase activity|enzyme activator activity	nucleus|cytoplasm
YLR353W	YLR353W	BUD8	hom	Verified	0.510470259837469	0.304861022453708	no	1479	0.266298254790096	910	NA	FT	CELL CYCLE|CELL DIVISION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole	pseudohyphal growth|cellular bud site selection	molecular_function	incipient cellular bud site|plasma membrane|cellular bud tip
YKR088C	YKR088C	TVP38	hom	Verified	0.508671051106702	0.305491408556788	no	1480	0.30388456692032	1059	NA	FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|CYTOSKELETON ORGANIZATION	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; required for asymmetric localization of Kar9p during mitosis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern	vesicle-mediated transport|mitotic spindle elongation	molecular_function	integral to membrane|integral to Golgi membrane|cytoplasm
YDR428C	YDR428C	BNA7	hom	Verified	0.50788623799461	0.305766563253549	no	1481	0.289811192358597	975	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			Formylkynurenine formamidase, involved in the de novo biosynthesis of NAD from tryptophan via kynurenine	NAD biosynthetic process	arylformamidase activity	cellular_component
YCR095C_p	YCR095C	OCA4	hom	Uncharacterized	0.507446372931692	0.305920827485907	no	1482	0.298122329952884	1018	NA					Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts	biological_process	molecular_function	cytoplasm
YAL067C	YAL067C	SEO1	hom	Verified	0.506813083364745	0.3061429877303	no	1483	0.294910599924471	963	NA					Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide	transport	transporter activity	integral to membrane|membrane
YIL102C_p	YIL102C	YIL102C	hom	Uncharacterized	0.504068995694758	0.307106446648656	no	1484	0.293782179612412	975	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YNL311C	YNL311C	SKP2	hom	Verified	0.503715446610685	0.307230676079535	no	1485	0.304311552291164	1030	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|PROTEOLYSIS		UBIQUITIN LIGASE COMPLEX	F-box protein of unknown function predicted to be part of an SCF ubiquitin protease complex; involved in regulating protein levels of sulfur metabolism enzymes; may interact with ribosomes, based on co-purification experiments	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular protein catabolic process|regulation of sulfur amino acid metabolic process	ubiquitin-protein ligase activity|protein binding, bridging	ribosome|SCF ubiquitin ligase complex
YML026C	YML026C	RPS18B	hom	Verified	0.502355885033882	0.307708602374268	no	1486	0.305594416714209	1050	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION	MITOCHONDRION	RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18B has a paralog, RPS18A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	cytoplasmic translation|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA export from nucleus	structural constituent of ribosome	cytosolic small ribosomal subunit|mitochondrion
YNL064C	YNL064C	YDJ1	hom	Verified	0.502262607140989	0.307741404302804	no	1487	0.247100822520689	856	NA	FT	PROTEIN LOCALIZATION|PROTEOLYSIS|MITOCHONDRION ORGANIZATION			Type I HSP40 co-chaperone; involved in regulation of HSP90 and HSP70 functions; critical for determining cell size at Start as a function of growth rate; involved in protein translocation across membranes; member of the DnaJ family	protein refolding|ER-associated protein catabolic process|protein targeting to mitochondrion|protein targeting to ER|'de novo' protein folding	unfolded protein binding|ATPase activator activity	cytosol|TRC complex|perinuclear region of cytoplasm
YKL216W	YKL216W	URA1	hom	Verified	0.501743835530238	0.307923862587748	no	1488	0.294882749613446	1009	NA	FT	OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM			Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid	'de novo' pyrimidine nucleobase biosynthetic process	dihydroorotate dehydrogenase activity	extrinsic to membrane|cytoplasm
YGL138C_p	YGL138C	YGL138C	hom	Uncharacterized	0.501497855921057	0.308010393210493	no	1489	0.307579436572346	1043	NA					Putative protein of unknown function; has no significant sequence similarity to any known protein	biological_process	molecular_function	cellular_component
YNR032W	YNR032W	PPG1	hom	Verified	0.500961894018732	0.308198970669359	no	1490	0.310645203133029	1036	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Putative serine/threonine protein phosphatase of the type 2A-like phosphatase family, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases	glycogen metabolic process|protein dephosphorylation	protein serine/threonine phosphatase activity	nucleus|cytoplasm
YMR115W	YMR115W	MGR3	hom	Verified	0.500478648943909	0.308369043198934	no	1491	0.302801296168179	1056	NA	FT	PROTEOLYSIS	MITOCHONDRION		Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA	misfolded or incompletely synthesized protein catabolic process	misfolded protein binding	mitochondrion|mitochondrial inner membrane|i-AAA complex
YDR028C	YDR028C	REG1	hom	Verified	0.499802297413827	0.308607146391484	no	1492	0.389743435006015	1290	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Regulatory subunit of type 1 protein phosphatase Glc7p; involved in negative regulation of glucose-repressible genes; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p	cellular response to glucose starvation|vacuolar protein catabolic process|glycogen metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of carbohydrate metabolic process	protein phosphatase type 1 regulator activity	protein phosphatase type 1 complex|cytoplasm
YEL038W	YEL038W	UTR4	hom	Verified	0.499503214653573	0.308712461337962	no	1493	0.271625495356979	913	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Protein with sequence similarity to 2,3-diketo-5-methylthiopentyl-1-phosphate enolase-phosphatases, involved in methionine salvage; found in both the cytoplasm and nucleus	L-methionine salvage from methylthioadenosine	acireductone synthase activity	nucleus|cytoplasm
YDR105C	YDR105C	TMS1	hom	Verified	0.498844422858355	0.308944494835375	no	1494	0.316783936802765	1087	NA					Vacuolar membrane protein of unknown function that is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p, a protein involved in multidrug resistance	biological_process	molecular_function	fungal-type vacuole membrane|integral to membrane|membrane
YBR179C	YBR179C	FZO1	hom	Verified	0.497855451083542	0.30929296440158	no	1495	0.315827167544405	1049	NA	FT	MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitofusin; integral membrane protein involved in mitochondrial outer membrane tethering and fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system	mitochondrial fusion	GTPase activity|protein homodimerization activity	mitochondrial outer membrane|mitochondrion|mitochondrial inner membrane|integral to mitochondrial outer membrane
YDR535C_d	YDR535C	YDR535C	hom	Dubious	0.496767237074141	0.30967660081004	no	1496	0.343555640610867	1165	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YDR535C is not an essential gene.	Unknown	Unknown	Unknown
YDR268W	YDR268W	MSW1	hom	Verified	0.496213238873069	0.309871985741164	no	1497	0.323928372490305	1087	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial tryptophanyl-tRNA synthetase	mitochondrial tryptophanyl-tRNA aminoacylation	tryptophan-tRNA ligase activity	mitochondrion
YNR018W	YNR018W	RCF2	hom	Verified	0.495806930229972	0.310015317442666	no	1498	0.304674514010467	1001	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast	mitochondrial respiratory chain complex IV assembly	molecular_function	mitochondrion|mitochondrial respiratory chain supercomplex|mitochondrial respiratory chain complex IV|integral to mitochondrial inner membrane
YHR096C	YHR096C	HXT5	hom	Verified	0.49484718782426	0.310353996156507	no	1499	0.329191635142741	1100	NA	FT		PLASMA MEMBRANE		Hexose transporter with moderate affinity for glucose; induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs; HXT5 has a paralog, HXT3, that arose from the whole genome duplication	glucose transport|hexose transport	mannose transmembrane transporter activity|fructose transmembrane transporter activity|glucose transmembrane transporter activity	integral to membrane|plasma membrane
YOL007C	YOL007C	CSI2	hom	Verified	0.494064715126079	0.310630238112781	no	1500	0.303257853637924	1031	NA	FT		SITE OF POLARIZED GROWTH		Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene	biological_process	molecular_function	fungal-type vacuole|cellular bud neck
YMR071C	YMR071C	TVP18	hom	Verified	0.493040526766983	0.310991976069064	no	1501	0.334469228149096	1141	NA	FF|FT	VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments	vesicle-mediated transport	molecular_function	integral to membrane|integral to Golgi membrane|clathrin-coated vesicle
YDR234W	YDR234W	LYS4	hom	Verified	0.492250718180544	0.311271057111102	no	1502	0.323302848478238	1110	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway	lysine biosynthetic process via aminoadipic acid	homoaconitate hydratase activity	mitochondrion
YDR034W-B_p	YDR034W-B	YDR034W-B	hom	Uncharacterized	0.492167540517408	0.311300454486345	no	1503	0.319615369895207	1075	NA					Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery	biological_process	molecular_function	cellular_component
YML100W	YML100W	TSL1	hom	Verified	0.491379465996522	0.31157904235403	no	1504	0.280363237436375	948	NA	FT	CARBOHYDRATE METABOLISM			Large subunit of trehalose 6-phosphate synthase/phosphatase complex; Tps1p-Tps2p complex converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress; TSL1 has a paralog, TPS3, that arose from the whole genome duplication	trehalose biosynthetic process|response to stress	enzyme regulator activity|alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity|trehalose-phosphatase activity	alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
YDR026C	YDR026C	NSI1	hom	Verified	0.491076156359784	0.31168629243039	no	1505	0.279257103768111	921	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		RNA polymerase I termination factor; binds to rDNA terminator element, required for efficient Pol I termination; required for rDNA silencing at NTS1; facilities association of Sir2p with NTS1, contributes to rDNA stability and cell longevity; interacts physically with Fob1p and RENT subunits, Sir2p and Net1p; may interact with ribosomes, based on co-purification experiments; Myb-like DNA-binding protein; NSI1 has a paralog, REB1, that arose from the whole genome duplication	termination of RNA polymerase I transcription|chromatin silencing at rDNA|Unknown	DNA binding	ribosome|nucleolus|rDNA heterochromatin
YIL145C	YIL145C	PAN6	hom	Verified	0.489836520001537	0.312124792979672	no	1506	0.284006872491956	960	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM	NUCLEUS		Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC	pantothenate biosynthetic process	pantoate-beta-alanine ligase activity	nucleus|cytoplasm
YGR171C	YGR171C	MSM1	hom	Verified	0.489794223610614	0.312139759319663	no	1507	0.319250157972428	1058	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION	MITOCHONDRION		Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p	methionyl-tRNA aminoacylation	methionine-tRNA ligase activity	mitochondrion
YHR091C	YHR091C	MSR1	hom	Verified	0.488531596757874	0.312586675416171	no	1508	0.297801584585186	1042	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial arginyl-tRNA synthetase; mutations in human ortholog are associated with pontocerebellar hypoplasia type 6	arginyl-tRNA aminoacylation|mitochondrial arginyl-tRNA aminoacylation|mitochondrial translation	arginine-tRNA ligase activity	mitochondrion
YPR170C_d	YPR170C	YPR170C	hom	Dubious	0.487353802271056	0.313003813070378	no	1509	0.369142242478037	1202	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORFs YPR169W-A and YPR170W-B	Unknown	Unknown	Unknown
YMR070W	YMR070W	MOT3	hom	Verified	0.486937421671882	0.313151339269549	no	1510	0.341523811227823	1161	NA	FT	TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM	NUCLEUS		Transcriptional repressor and activator with two C2-H2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes in response to hyperosmotic stress; contributes to recruitment of the Tup1p-Cyc8p general repressor to promoters; involved in positive transcriptional regulation of CWP2 and other genes; can form the [MOT3+] prion	cellular hyperosmotic response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of ergosterol biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II repressing transcription factor binding|RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding	nucleus
YBR001C	YBR001C	NTH2	hom	Verified	0.486683461545139	0.313241333587556	no	1511	0.374328200577187	1268	NA	FF|FT	CARBOHYDRATE METABOLISM	MITOCHONDRION		Putative neutral trehalase, required for thermotolerance; may mediate resistance to other cellular stresses; NTH2 has a paralog, NTH1, that arose from the whole genome duplication	trehalose catabolic process	alpha,alpha-trehalase activity	mitochondrion|cytoplasm
YER091C-A_d	YER091C-A	YER091C-A	hom	Dubious	0.486574557140839	0.31327992879243	no	1512	0.326612641025252	1103	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPL022W	YPL022W	RAD1	hom	Verified	0.484851537715373	0.313890830638009	no	1513	0.314671681915924	1052	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS		Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein	mitotic recombination|meiotic mismatch repair|nucleotide-excision repair, DNA incision, 5'-to lesion|double-strand break repair via single-strand annealing, removal of nonhomologous ends|removal of nonhomologous ends	single-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity	nucleotide-excision repair factor 1 complex|nucleus
YNR009W	YNR009W	NRM1	hom	Verified	0.484621292775856	0.313972503392645	no	1514	0.304671736106847	1047	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE	NUCLEUS		Transcriptional co-repressor of MBF (MCB binding factor)-regulated gene expression; Nrm1p associates stably with promoters via MBF to repress transcription upon exit from G1 phase	negative regulation of transcription involved in G1 phase of mitotic cell cycle	repressing transcription factor binding|transcription factor binding transcription factor activity	MBF transcription complex|nucleus|cytoplasm
YDR131C_p	YDR131C	YDR131C	hom	Uncharacterized	0.484378325859266	0.314058698784773	no	1515	0.287362626706275	985	NA	FT	PROTEOLYSIS			F-box protein, substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity|protein binding, bridging	SCF ubiquitin ligase complex
YGR080W	YGR080W	TWF1	hom	Verified	0.484343908260478	0.314070909656098	no	1516	0.305515425068913	1059	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Twinfilin, highly conserved actin monomer-sequestering protein involved in regulation of the cortical actin cytoskeleton, composed of two cofilin-like regions, localizes actin monomers to sites of rapid filament assembly	bipolar cellular bud site selection|actin polymerization or depolymerization|sequestering of actin monomers	actin monomer binding	mating projection tip|actin cortical patch
YOR193W	YOR193W	PEX27	hom	Verified	0.484001807431255	0.314192293198068	no	1517	0.311300571793887	1038	NA	FT	PEROXISOME ORGANIZATION			Peripheral peroxisomal membrane protein involved in controlling peroxisome size and number, interacts with homologous protein Pex25p	peroxisome organization	molecular_function	peroxisomal membrane
YGL079W_p	YGL079W	KXD1	hom	Uncharacterized	0.482367404423335	0.314772486068598	no	1518	0.304966922210069	1022	NA					Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; GFP-fusion protein localizes to the endosome	biological_process	molecular_function	endosome
YLR354C	YLR354C	TAL1	hom	Verified	0.480948673211105	0.315276489163065	no	1519	0.343694512063632	1169	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Transaldolase, enzyme in the non-oxidative pentose phosphate pathway; converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate	pentose-phosphate shunt	sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity	nucleus|cytoplasm
YMR186W	YMR186W	HSC82	hom	Verified	0.480726645338675	0.315355395533357	no	1520	0.318188561716631	1078	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS	MITOCHONDRION		Cytoplasmic chaperone of the Hsp90 family; redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock; contains two acid-rich unstructured regions that promote the solubility of chaperone-substrate complexes; HSC82 has a paralog, HSP82, that arose from the whole genome duplication	protein folding|proteasome assembly|protein refolding|telomere maintenance|'de novo' protein folding|box C/D snoRNP assembly|response to stress	unfolded protein binding|ATPase activity, coupled|ATPase activity	mitochondrion|plasma membrane|cytoplasm
YDL173W	YDL173W	PAR32	hom	Verified	0.480562251170898	0.315413824918252	no	1521	0.336777619262864	1141	NA					Putative protein of unknown function; hyperphosphorylated upon rapamycin treatment in a Tap42p-dependent manner; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; PAR32 is not an essential gene	biological_process	molecular_function	cytoplasm
YAR035C-A_p	YAR035C-A	YAR035C-A	hom	Uncharacterized	0.480174944274988	0.315551500747533	no	1522	0.299431619298104	1023	NA					Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; predicted to have a role in cell budding based on computational guilt by association analysis	biological_process	molecular_function	cellular_component
YJL162C	YJL162C	JJJ2	hom	Verified	0.479069381435465	0.315944635549002	no	1523	0.303851938454899	1021	NA	FT		NUCLEUS		Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein	biological_process	molecular_function	nucleus|cytoplasm
YLR306W	YLR306W	UBC12	hom	Verified	0.47771305513943	0.316427225533455	no	1524	0.30389853842438	1032	NA					Enzyme that mediates the conjugation of Rub1p, a ubiquitin-like protein, to other proteins; related to E2 ubiquitin-conjugating enzymes	protein neddylation	NEDD8 ligase activity	cellular_component
YOR313C	YOR313C	SPS4	hom	Verified	0.477555015150539	0.316483477580115	no	1525	0.319461316312556	1084	NA	FT	CELL CYCLE			Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage	ascospore formation	molecular_function	cellular_component
YGL148W	YGL148W	ARO2	hom	Verified	0.477358634371141	0.316553382391716	no	1526	0.389789944685078	1283	NA	FF|FT	KETONE METABOLISM|AMINO ACID METABOLISM			Bifunctional chorismate synthase and flavin reductase; catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids; protein abundance increases in response to DNA replication stress	aromatic amino acid family biosynthetic process	chorismate synthase activity|riboflavin reductase (NADPH) activity	cytoplasm
YGR210C_p	YGR210C	YGR210C	hom	Uncharacterized	0.476474910910363	0.316868038657779	no	1527	0.303255328864611	995	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm
YDR085C	YDR085C	AFR1	hom	Verified	0.474918044989802	0.317422694531036	no	1528	0.313520171384032	1067	NA	FT	SIGNALING			Protein required for pheromone-induced projection (shmoo) formation; regulates septin architecture during mating; has an RVXF motif that mediates targeting of Glc7p to mating projections; interacts with Cdc12p; AFR1 has a paralog, YER158C, that arose from the whole genome duplication	regulation of G-protein coupled receptor protein signaling pathway|pheromone-dependent signal transduction involved in conjugation with cellular fusion|cell morphogenesis involved in conjugation with cellular fusion|cell morphogenesis involved in conjugation	receptor signaling protein activity	mating projection base
YKL062W	YKL062W	MSN4	hom	Verified	0.474917401828704	0.317422923751274	no	1529	0.318304069546922	1067	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Transcriptional activator; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression; MSN4 has a paralog, MSN2, that arose from the whole genome duplication	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription from RNA polymerase II promoter in response to a hypotonic environment|positive regulation of transcription from RNA polymerase II promoter in response to alkalinity|positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation|positive regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation|positive regulation of transcription from RNA polymerase II promoter in response to acidity|chromatin remodeling|regulation of replicative cell aging by regulation of transcription from RNA polymerase II promoter in response to caloric restriction|positive regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide|positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance|positive regulation of transcription from RNA polymerase II promoter in response to increased salt|cellular response to acidity|positive regulation of transcription from RNA polymerase II promoter in response to freezing|positive regulation of transcription from RNA polymerase II promoter in response to ethanol|replicative cell aging|age-dependent response to oxidative stress involved in chronological cell aging|positive regulation of transcription from RNA polymerase II promoter in response to hydrostatic pressure|positive regulation of transcription from RNA polymerase II promoter in response to nitrosative stress|positive regulation of transcription from RNA polymerase II promoter in response to cold|positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding	cytosol|nucleus
YER120W	YER120W	SCS2	hom	Verified	0.474181589415488	0.317685210417184	no	1530	0.313342653637967	1072	NA	FT	PROTEIN LOCALIZATION|LIPID METABOLISM|GENE SILENCING	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH		Integral ER membrane protein, regulates phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PI4P levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; interacts with FFAT motif of Opi1p; involved in telomeric silencing; null shows inositol auxotrophy above 34 deg C; VAP homolog; SCS2 has a paralog, SCS22, that arose from the whole genome duplication	endoplasmic reticulum inheritance|regulation of intracellular lipid transport|negative regulation of transcription factor import into nucleus|phospholipid biosynthetic process|chromatin silencing at telomere	phosphatidylinositol binding|FFAT motif binding	nuclear membrane|integral to endoplasmic reticulum membrane|nuclear envelope|endoplasmic reticulum|cellular bud tip
YMR077C	YMR077C	VPS20	hom	Verified	0.474107485380314	0.317711630513167	no	1531	0.347384381641073	1176	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT			Myristoylated subunit of ESCRTIII, the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranes	intralumenal vesicle formation|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|late endosome to vacuole transport	protein binding	ESCRT III complex|cytoplasm
YLR292C	YLR292C	SEC72	hom	Verified	0.47362508428795	0.317883642255037	no	1532	0.333515475330587	1121	NA	FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER	posttranslational protein targeting to membrane, translocation	protein transporter activity	Sec62/Sec63 complex|endoplasmic reticulum membrane
YDR401W_d	YDR401W	YDR401W	hom	Dubious	0.473199474818594	0.318035436211995	no	1533	0.333427537795555	1124	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YNR063W_p	YNR063W	YNR063W	hom	Uncharacterized	0.471686920644783	0.3185751371199	no	1534	0.303441630139462	1032	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Putative zinc-cluster protein of unknown function	biological_process	sequence-specific DNA binding	cellular_component
YLR312W-A	YLR312W-A	MRPL15	hom	Verified	0.470882745335213	0.318862235240533	no	1535	0.325031454324842	1137	NA	FT	RNA PROCESSING|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YKL094W	YKL094W	YJU3	hom	Verified	0.470447322450096	0.319017730676755	no	1536	0.316577460938397	1105	NA	FT	LIPID METABOLISM	ENDOPLASMIC RETICULUM|MITOCHONDRION		Monoglyceride lipase (MGL), functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family	triglyceride metabolic process	serine hydrolase activity|acylglycerol lipase activity	mitochondrial outer membrane|lipid particle|plasma membrane|membrane|cytoplasm
YER184C_p	YER184C	YER184C	hom	Uncharacterized	0.470090553024849	0.319145161637199	no	1537	0.329677291188969	1134	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Putative zinc cluster protein; deletion confers sensitivity to Calcufluor white, and prevents growth on glycerol or lactate as sole carbon source	biological_process	sequence-specific DNA binding	cellular_component
YER080W	YER080W	AIM9	hom	Verified	0.46866323240306	0.31965518592185	no	1538	0.330474965719656	1123	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	mitochondrion
YJL038C	YJL038C	LOH1	hom	Verified	0.468188183479055	0.319825010826593	no	1539	0.325557185238216	1105	NA					Protein of unknown function with proposed roles in maintenance of genome integrity and also in spore wall assembly; induced during sporulation; repressed during vegetative growth by Sum1p and Hst1p; sequence similar to IRC1	chromosome organization	molecular_function	cellular_component
YDR269C_d	YDR269C	YDR269C	hom	Dubious	0.467064824302629	0.320226749934357	no	1540	0.311789255325245	1040	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKR102W	YKR102W	FLO10	hom	Verified	0.466933785475738	0.320273626175357	no	1541	0.306348456178972	1025	NA					Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth	filamentous growth of a population of unicellular organisms|flocculation via cell wall protein-carbohydrate interaction|flocculation|invasive growth in response to glucose limitation	mannose binding	fungal-type cell wall
YJL166W	YJL166W	QCR8	hom	Verified	0.466166259535006	0.320548249179673	no	1542	0.308731309654247	1014	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p	mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration	ubiquinol-cytochrome-c reductase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex III
YOR009W	YOR009W	TIR4	hom	Verified	0.464815170734331	0.321031911350897	no	1543	0.315063501670351	1044	NA	FT	CELL WALL ORG/BIOGENESIS			Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth; transcription is also induced by cold shock	biological_process	molecular_function	fungal-type cell wall
YPR057W	YPR057W	BRR1	hom	Verified	0.464543963802646	0.321129034526968	no	1544	0.261073393861862	916	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING	NUCLEUS		snRNP protein component of spliceosomal snRNPs, required for pre-mRNA splicing and snRNP biogenesis; in null mutant newly-synthesized snRNAs are destabilized and 3'-end processing is slowed	spliceosomal complex assembly	RNA binding	small nuclear ribonucleoprotein complex
YMR271C	YMR271C	URA10	hom	Verified	0.464193982124482	0.321254386178048	no	1545	0.301125925779297	1020	NA	FT	NUCLEOTIDE METABOLISM			Minor orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA10 has a paralog, URA5, that arose from the whole genome duplication	'de novo' pyrimidine nucleobase biosynthetic process|pyrimidine ribonucleoside biosynthetic process	orotate phosphoribosyltransferase activity	cytoplasm
YBR034C	YBR034C	HMT1	hom	Verified	0.462714388753068	0.321784551604981	no	1546	0.338068700075425	1133	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA LOCALIZATION	NUCLEUS		Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs, including Npl3p and Hrp1p, affecting their activity and nuclear export; methylates U1 snRNP protein Snp1p and ribosomal protein Rps2p; interacts genetically with genes encoding components of Rpd3(L) and this interaction is important for Rpd3 recruitment to the subtelomeric region.	mRNA export from nucleus|negative regulation of DNA-dependent transcription, termination|positive regulation of transcription elongation from RNA polymerase II promoter|peptidyl-arginine methylation	protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity	nucleus
YGL199C_d	YGL199C	YGL199C	hom	Dubious	0.462228824913952	0.321958617204358	no	1547	0.297159211987303	993	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YIP4/YGL198W	Unknown	Unknown	Unknown
YDR252W	YDR252W	BTT1	hom	Verified	0.461110200099176	0.322359772018229	no	1548	0.320949201975994	1084	NA	FT	PROTEIN LOCALIZATION	NUCLEUS		Beta3 subunit of the heterotrimeric nascent polypeptide-associated complex which binds ribosomes via its beta-subunits in close proximity to nascent polypeptides; interacts with Caf130p of the CCR4-NOT complex; similar to human BTF3	'de novo' cotranslational protein folding	unfolded protein binding	nascent polypeptide-associated complex|CCR4-NOT complex
YDR359C	YDR359C	EAF1	hom	Verified	0.46094734229223	0.322418192419873	no	1549	0.357001527379717	1154	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS	HISTONE ACETYLTRANSFERASE	Component of the NuA4 histone acetyltransferase complex; acts as a platform for assembly of NuA4 subunits into the native complex; required for initiation of pre-meiotic DNA replication, likely due to its requirement for expression of IME1	DNA repair|cellular protein complex assembly|chromatin modification	molecular_function	histone acetyltransferase complex|NuA4 histone acetyltransferase complex
YGR261C	YGR261C	APL6	hom	Verified	0.460611743251184	0.322538592438398	no	1550	0.349702496435575	1161	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools	vesicle-mediated transport|Golgi to vacuole transport	molecular_function	AP-3 adaptor complex
YJR052W	YJR052W	RAD7	hom	Verified	0.460438360491334	0.322600802791803	no	1551	0.323713011383077	1079	NA	FT	RESPONSE TO DNA DAMAGE|PROTEOLYSIS	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex	nucleotide-excision repair, DNA damage recognition|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	damaged DNA binding|ubiquitin-protein ligase activity|DNA-dependent ATPase activity	nucleotide-excision repair factor 4 complex|Cul3-RING ubiquitin ligase complex
YOL112W	YOL112W	MSB4	hom	Verified	0.460415436847311	0.322609028248908	no	1552	0.324619153102988	1122	NA	FT	SIGNALING|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH		GTPase-activating protein of the Ras superfamily that acts primarily on Sec4p, localizes to the bud site and bud tip, has similarity to Msb3p; msb3 msb4 double mutation causes defects in secretion and actin organization	actin filament organization	Rab GTPase activator activity	incipient cellular bud site|polarisome|cellular bud tip
YML042W	YML042W	CAT2	hom	Verified	0.460233281367138	0.322674392325304	no	1553	0.313484911086379	1039	NA	FT	KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes	carnitine metabolic process	carnitine O-acetyltransferase activity	mitochondrion|peroxisomal matrix|peroxisome
YML103C	YML103C	NUP188	hom	Verified	0.459021980037414	0.323109191031195	no	1554	0.301126357283064	1012	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188	nuclear pore organization|protein import into nucleus|mRNA export from nucleus in response to heat stress	structural constituent of nuclear pore	integral to membrane|nuclear pore|nuclear pore inner ring
YOR321W	YOR321W	PMT3	hom	Verified	0.457794553149358	0.323550024703502	no	1555	0.31172795169796	1068	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt5p, can instead interact with Pmt1p in some conditions; antifungal drug target; PMT3 has a paralog, PMT2, that arose from the whole genome duplication	protein O-linked glycosylation|protein O-linked mannosylation	dolichyl-phosphate-mannose-protein mannosyltransferase activity	integral to membrane|dolichyl-phosphate-mannose-protein mannosyltransferase complex
YKR012C_d	YKR012C	YKR012C	hom	Dubious	0.457757556418973	0.32356331602827	no	1556	0.292157838954692	1007	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PRY2	Unknown	Unknown	Unknown
YDL170W	YDL170W	UGA3	hom	Verified	0.457509427803602	0.323652463722525	no	1557	0.319180068378663	1063	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		Transcriptional activator necessary for gamma-aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1, UGA2, UGA4); zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus	nitrogen utilization|nitrogen catabolite activation of transcription from RNA polymerase II promoter|gamma-aminobutyric acid catabolic process	sequence-specific DNA binding transcription factor recruiting transcription factor activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YGL158W	YGL158W	RCK1	hom	Verified	0.456868464812565	0.323882795851403	no	1558	0.308826372906701	1026	NA	FT	CELL CYCLE|PROTEIN PHOSPHORYLATION			Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations; RCK1 has a paralog, RCK2, that arose from the whole genome duplication	protein phosphorylation|regulation of meiosis	protein serine/threonine kinase activity|protein kinase activity	cellular_component
YOR003W	YOR003W	YSP3	hom	Verified	0.456241861474273	0.324108033002382	no	1559	0.312710741952069	1051	NA	FT	PROTEOLYSIS			Putative precursor to the subtilisin-like protease III	protein catabolic process	peptidase activity	cellular_component
YLR415C_p	YLR415C	YLR415C	hom	Uncharacterized	0.455887426809749	0.324235465654791	no	1560	0.325616210548644	1108	NA	FT		MITOCHONDRION		Putative protein of unknown function; YLR415C is not an essential gene	biological_process	molecular_function	cellular_component
YAL021C	YAL021C	CCR4	hom	Verified	0.454030392175405	0.324903476066669	no	1561	0.366896230715285	1204	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RNA PROCESSING	NUCLEUS	RNA POL II, HOLOENZYME	Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening	regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|DNA replication checkpoint|nuclear-transcribed mRNA poly(A) tail shortening|traversing start control point of mitotic cell cycle|replication fork protection|transcription elongation from RNA polymerase II promoter|DNA replication	3'-5'-exoribonuclease activity	CCR4-NOT core complex|cytoplasmic mRNA processing body|Cdc73/Paf1 complex|cytoplasm
YBR005W	YBR005W	RCR1	hom	Verified	0.453499517594335	0.325094545318971	no	1562	0.309264320414088	1061	NA	FT	VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein of the ER membrane involved in cell wall chitin deposition; may function in the endosomal-vacuolar trafficking pathway, helping determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR1 has a paralog, RCR2, that arose from the whole genome duplication	fungal-type cell wall organization|vesicle-mediated transport	molecular_function	integral to endoplasmic reticulum membrane
YBR148W	YBR148W	YSW1	hom	Verified	0.452478918245206	0.325462002628523	no	1563	0.302028886697733	1027	NA	FT	MEMBRANE ORGANIZATION			Protein required for normal prospore membrane formation; interacts with Gip1p, which is the meiosis-specific regulatory subunit of the Glc7p protein phosphatase; expressed specifically in spores and localizes to the prospore membrane	ascospore-type prospore membrane assembly	molecular_function	prospore membrane
YNR023W	YNR023W	SNF12	hom	Verified	0.450719744260313	0.326095775115859	no	1564	0.483618193550537	1740	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS	RSC COMPLEX	73 kDa subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; homolog of Rsc6p subunit of the RSC chromatin remodeling complex; relocates to the cytosol under hypoxic conditions; deletion mutants are temperature-sensitive	positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation|positive regulation of transcription from RNA polymerase II promoter	molecular_function	SWI/SNF complex
YGR026W_p	YGR026W	YGR026W	hom	Uncharacterized	0.450067480790767	0.326330892012801	no	1565	0.336886414883651	1143	NA	FT		PLASMA MEMBRANE		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery	biological_process	molecular_function	integral to membrane
YER170W	YER170W	ADK2	hom	Verified	0.448968554774688	0.326727170349702	no	1566	0.325305327813185	1114	NA	FT	NUCLEOTIDE METABOLISM	MITOCHONDRION		Mitochondrial adenylate kinase, catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background	nucleotide metabolic process	nucleoside triphosphate adenylate kinase activity|adenylate kinase activity	mitochondrion|mitochondrial inner membrane
YBR182C-A_p	YBR182C-A	YBR182C-A	hom	Uncharacterized	0.447724001086486	0.327176198905338	no	1567	0.336174606207111	1155	NA					Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YCR047C	YCR047C	BUD23	hom	Verified	0.446793817891556	0.327511967669935	no	1568	0.309207027644597	1046	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|CELL DIVISION	NUCLEUS		Methyltransferase, methylates residue G1575 of 18S rRNA; required for rRNA processing and nuclear export of 40S ribosomal subunits independently of methylation activity; diploid mutant displays random budding pattern	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA (guanine-N7)-methylation|cellular bud site selection|ribosomal small subunit export from nucleus	S-adenosylmethionine-dependent methyltransferase activity|rRNA (guanine) methyltransferase activity	nucleolus|nucleus|cytoplasm
YML067C	YML067C	ERV41	hom	Verified	0.446332636708614	0.327678492277064	no	1569	0.329603588670146	1093	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Protein localized to COPII-coated vesicles, forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 (PTX1) protein	ER to Golgi vesicle-mediated transport	molecular_function	integral to endoplasmic reticulum membrane|integral to Golgi membrane|ER to Golgi transport vesicle
YJL129C	YJL129C	TRK1	hom	Verified	0.445747559976279	0.327889802768601	no	1570	0.364323522164645	1214	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication	cellular potassium ion homeostasis	potassium ion transmembrane transporter activity	membrane raft|integral to membrane|plasma membrane
YGR036C	YGR036C	CAX4	hom	Verified	0.445149750797865	0.32810576872931	no	1571	0.340820399654809	1120	NA	FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation	lipid biosynthetic process|protein N-linked glycosylation	dolichyldiphosphatase activity	integral to endoplasmic reticulum membrane|integral to membrane
YCR068W	YCR068W	ATG15	hom	Verified	0.444902459394411	0.328195122617759	no	1572	0.346731341888347	1156	NA	FT	LIPID METABOLISM|MEMBRANE ORGANIZATION|VACUOLAR PROTEIN PROCESSING	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Lipase required for intravacuolar lysis of autophagic bodies and Cvt bodies; targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway	membrane disassembly|autophagy|piecemeal microautophagy of nucleus|vacuolar protein processing|multivesicular body membrane disassembly	lipase activity	integral to membrane|vacuolar lumen
YAR014C	YAR014C	BUD14	hom	Verified	0.441343107051545	0.329482311583315	no	1573	0.325901637081989	1132	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH		Protein involved in bud-site selection; Bud14p-Glc7p complex is a cortical regulator of dynein; inhibitor of the actin assembly factor Bnr1p (formin); diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; relative distribution to the nucleus increases upon DNA replication stress	regulation of cell shape during vegetative growth phase|regulation of protein localization|regulation of transcription, DNA-dependent|cytoskeleton organization|negative regulation of actin filament polymerization	protein phosphatase type 1 regulator activity	incipient cellular bud site|cellular bud neck|cellular bud tip
YER155C	YER155C	BEM2	hom	Verified	0.441010666009469	0.329602637672574	no	1574	0.339794800198848	1134	NA	FT	SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	MITOCHONDRION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Rho GTPase activating protein (RhoGAP) involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence	negative regulation of Rho protein signal transduction|fungal-type cell wall organization|establishment of cell polarity|actin cytoskeleton organization	Rho GTPase activator activity	cell cortex|incipient cellular bud site|mitochondrion|plasma membrane|mating projection tip|cytoplasm|cellular bud tip
YGR069W_d	YGR069W	YGR069W	hom	Dubious	0.440842280346432	0.329663591116003	no	1575	0.341965375244761	1144	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR102C	YLR102C	APC9	hom	Verified	0.440740292772825	0.329700511505737	no	1576	0.319655803064788	1051	NA	FT	CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION	NUCLEUS	UBIQUITIN LIGASE COMPLEX	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition	chromatin assembly|protein ubiquitination	ubiquitin-protein ligase activity	anaphase-promoting complex
YER154W	YER154W	OXA1	hom	Verified	0.439876267266191	0.330013362819236	no	1577	0.342343065131363	1149	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial inner membrane insertase, mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane, interacts with mitochondrial ribosomes; conserved from bacteria to animals	protein insertion into mitochondrial membrane from inner side|mitochondrial genome maintenance|mitochondrial proton-transporting ATP synthase complex assembly	mitochondrial ribosome binding|membrane insertase activity	mitochondrion|mitochondrial inner boundary membrane|integral to membrane|mitochondrial crista|mitochondrial large ribosomal subunit
YGL105W	YGL105W	ARC1	hom	Verified	0.439757495365514	0.330056377732448	no	1578	0.341303217335498	1173	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION			Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p), delivering tRNA to them, stimulating catalysis, and ensuring their localization to the cytoplasm; also binds quadruplex nucleic acids; protein abundance increases in response to DNA replication stress	positive regulation of ligase activity|tRNA aminoacylation for protein translation	enzyme activator activity|tRNA binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding	methionyl glutamyl tRNA synthetase complex|cytoplasm
YKL183W	YKL183W	LOT5	hom	Verified	0.43748842677171	0.330878583720769	no	1579	0.316213612382681	1073	NA	FT		NUCLEUS		Protein of unknown function; gene expression increases in cultures shifted to a lower temperature; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YMR170C	YMR170C	ALD2	hom	Verified	0.43631952464192	0.331302458939043	no	1580	0.323339173028281	1082	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS			Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p	cellular aldehyde metabolic process|beta-alanine biosynthetic process|polyamine catabolic process	aldehyde dehydrogenase (NAD) activity	cytoplasm
YOR012W_p	YOR012W	YOR012W	hom	Uncharacterized	0.436044367921604	0.331402269594578	no	1581	0.286744087417089	971	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YGR011W_d	YGR011W	YGR011W	hom	Dubious	0.435625048496714	0.331554397019952	no	1582	0.322503475788422	1080	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YNR021W_p	YNR021W	YNR021W	hom	Uncharacterized	0.434100110771655	0.332107872531813	no	1583	0.325627438195322	1082	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNR021W is not an essential gene	biological_process	molecular_function	endoplasmic reticulum
YKL076C_d	YKL076C	PSY1	hom	Dubious	0.43322462827264	0.332425794216321	no	1584	0.338078913368608	1166	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C	Unknown	Unknown	Unknown
YDR066C	YDR066C	RTR2	hom	Verified	0.433215959974694	0.332428942615138	no	1585	0.336382374333125	1112	NA	FT		NUCLEUS		Protein of unknown function; exhibits genetic interactions with Rtr1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDR066C is not an essential gene; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; RTR2 has a paralog, RTR1, that arose from the whole genome duplication	biological_process	molecular_function	cytoplasm
YER032W	YER032W	FIR1	hom	Verified	0.432989866749102	0.332511065754068	no	1586	0.358406271826785	1194	NA	FT	RNA PROCESSING	SITE OF POLARIZED GROWTH		Protein involved in 3' mRNA processing, interacts with Ref2p; potential Cdc28p substrate	mRNA polyadenylation|RNA polyadenylation	molecular_function	cellular bud neck
YMR247C	YMR247C	RKR1	hom	Verified	0.432920992516477	0.332536084325102	no	1587	0.32101545799262	1080	NA	FT	CHROMATIN ORGANIZATION|PROTEOLYSIS|GENE SILENCING	NUCLEUS		RING domain E3 ubiquitin ligase; involved in the ubiquitin-mediated degradation of non-stop proteins; functional connections to chromatin modification; nuclear protein that also co-localizes with ribosomes; homolog of mouse Listerin, whose mutation has been reported to cause neurodegeneration in mice	chromatin modification|chromatin silencing at telomere|ubiquitin-dependent protein catabolic process|protein ubiquitination	ubiquitin-protein ligase activity|ribosome binding	ribosome|nucleus
YJL049W_p	YJL049W	YJL049W	hom	Uncharacterized	0.432647379380172	0.332635481688274	no	1588	0.287112717318306	967	NA	FT	PROTEIN LOCALIZATION			Putative protein of unknown function; YJL049W is a non-essential gene	biological_process	molecular_function	cellular_component
YDL160C-A	YDL160C-A	MHF2	hom	Verified	0.431955205533697	0.332886985059551	no	1589	0.341691835907519	1148	NA	FT	RESPONSE TO DNA DAMAGE			Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM to stabilize and remodel blocked replication forks and repair damaged DNA; mhf2 srs2 double mutants are MMS hypersensitive; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-X, also known as MHF2	response to DNA damage stimulus	molecular_function	cellular_component
YJL218W_p	YJL218W	YJL218W	hom	Uncharacterized	0.431015921248563	0.333228396980515	no	1590	0.33555344218126	1142	NA					Putative acetyltransferase; similar to bacterial galactoside O-acetyltransferases; induced by oleate in an OAF1/PIP2-dependent manner; promoter contains an oleate response element consensus sequence; non-essential gene	biological_process	acetyltransferase activity	cellular_component
YNL283C	YNL283C	WSC2	hom	Verified	0.430737501602198	0.333329623785052	no	1591	0.358634221202133	1228	NA	FF|FT	SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity and recovery from heat shock; secretory pathway Wsc2p is required for the arrest of secretion response	fungal-type cell wall organization|response to heat|Rho protein signal transduction	transmembrane signaling receptor activity	site of polarized growth|cellular bud|mating projection tip|cytoplasm
YMR256C	YMR256C	COX7	hom	Verified	0.430289379308602	0.333492575954816	no	1592	0.353101020352534	1175	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain	mitochondrial electron transport, cytochrome c to oxygen	cytochrome-c oxidase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YOR002W	YOR002W	ALG6	hom	Verified	0.430124142572905	0.333552669458547	no	1593	0.37614810408192	1280	NA	FT	LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Alpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease	oligosaccharide-lipid intermediate biosynthetic process|protein glycosylation|aerobic respiration	transferase activity, transferring hexosyl groups|dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity	integral to membrane|endoplasmic reticulum
YDL151C_d	YDL151C	BUD30	hom	Dubious	0.429718981473504	0.333700037029845	no	1594	0.347272829545714	1159	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 96% of ORF overlaps the verified gene RPC53; diploid mutant displays a weak budding pattern phenotype in a systematic assay	Unknown	Unknown	Unknown
YOR115C	YOR115C	TRS33	hom	Verified	0.429321938280549	0.333844476802416	no	1595	0.327302496794599	1118	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS	ENDOPLASMIC RETICULUM|GOLGI APPARATUS		One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic	ER to Golgi vesicle-mediated transport|protein complex assembly	molecular_function	trans-Golgi network|TRAPP complex|cis-Golgi network
YPL111W	YPL111W	CAR1	hom	Verified	0.429293997437413	0.33385464228917	no	1596	0.345404629318923	1140	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS|SITE OF POLARIZED GROWTH		Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance	regulation of ornithine metabolic process|arginine catabolic process to ornithine	manganese ion binding|arginase activity|ornithine carbamoyltransferase inhibitor activity|zinc ion binding	cytosol|nucleus|mating projection tip|cytoplasm
YML037C_p	YML037C	YML037C	hom	Uncharacterized	0.428681935390888	0.334077354360442	no	1597	0.353369862843355	1176	NA					Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene	biological_process	molecular_function	clathrin-coated vesicle
YCR083W	YCR083W	TRX3	hom	Verified	0.428452698844531	0.334160782104474	no	1598	0.3122665004951	1067	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		Mitochondrial thioredoxin, highly conserved oxidoreductase required to maintain the redox homeostasis of the cell, forms the mitochondrial thioredoxin system with Trr2p, redox state is maintained by both Trr2p and Glr1p	cellular response to oxidative stress	disulfide oxidoreductase activity	mitochondrion
YDL091C	YDL091C	UBX3	hom	Verified	0.428047934001022	0.334308111160225	no	1599	0.324395914014795	1039	NA					Subunit of the DSC ubiquitin ligase complex; UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; ortholog of fission yeast Ucp10	biological_process	molecular_function	cytoplasm
YMR160W	YMR160W	YMR160W	hom	Verified	0.427874385977727	0.334371288168444	no	1600	0.325998729461224	1106	NA					Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; mutant has enhanced sensitivity to overexpression of mutant huntingtin; YMR160W is not an essential gene; relative distribution within the vacuolar membrane changes upon DNA replication stress	biological_process	molecular_function	fungal-type vacuole membrane
YDR482C	YDR482C	CWC21	hom	Verified	0.42747962524961	0.334515011117384	no	1601	0.347306857903528	1171	NA	FT	RNA PROCESSING	NUCLEUS		Protein involved in RNA splicing by the spliceosome; component of a complex containing Cef1p; interacts genetically with ISY1 and BUD13; may bind RNA; has similarity to S. pombe Cwf21p	mRNA splicing, via spliceosome	molecular_function	U2-type spliceosomal complex
YLR181C	YLR181C	VTA1	hom	Verified	0.427389151780536	0.334547953762963	no	1602	0.330144644334422	1117	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|VACUOLAR TRANSPORT			Multivesicular body (MVB) protein involved in endosomal protein sorting; regulates Vps4p activity by promoting its oligomerization; has an N-terminal Vps60- and Did2- binding domain, a linker region, and a C-terminal Vps4p binding domain	late endosome to vacuole transport via multivesicular body sorting pathway|positive regulation of protein oligomerization|late endosome to vacuole transport	ATPase activator activity	endosome|endosome membrane|multivesicular body
YLR297W	YLR297W	YLR297W	hom	Verified	0.425857507373299	0.335105839889567	no	1603	0.334250579091735	1125	NA					Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; not an essential gene; induced by treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from nucleus to vacuole upon DNA replication stress; YLR297W has a paralog, YOR186W, that arose from the whole genome duplication	biological_process	molecular_function	fungal-type vacuole
YNL301C	YNL301C	RPL18B	hom	Verified	0.425612176802395	0.335195232941202	no	1604	0.319485530310261	1080	NA	FT	TRANSLATION		RIBOSOME	Ribosomal 60S subunit protein L18B; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18B has a paralog, RPL18A, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic large ribosomal subunit
YDL156W	YDL156W	CMR1	hom	Verified	0.423718966795518	0.335885390559735	no	1605	0.347864226645005	1198	NA	FT		NUCLEUS|CHROMOSOME		DNA-binding protein with preference for UV-damaged DNA; protein sequence contains three WD domains (WD-40 repeat); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; potential regulatory target of Mbp1p, which binds to the promoter region; co-localizes with Hos2p in nuclear foci in response to DNA damage by MMS	biological_process	DNA binding	nuclear chromatin|nucleus|cytoplasm
YPR009W	YPR009W	SUT2	hom	Verified	0.423686948799013	0.335897067284265	no	1606	0.348237558859593	1156	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1p	positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II repressing transcription factor binding|sequence-specific DNA binding	nucleus
YIR020C_p	YIR020C	YIR020C	hom	Uncharacterized	0.422747274596087	0.336239829959014	no	1607	0.308446296278245	1033	NA					Protein of unknown function; mRNA identified as translated by ribosome profiling data	biological_process	molecular_function	cellular_component
YLR165C	YLR165C	PUS5	hom	Verified	0.422719997825646	0.336249781675461	no	1608	0.342860538704524	1142	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	MITOCHONDRION		Pseudouridine synthase, catalyzes only the formation of pseudouridine (Psi)-2819 in mitochondrial 21S rRNA; not essential for viability	rRNA modification|pseudouridine synthesis	pseudouridylate synthase activity	mitochondrion
YLR226W	YLR226W	BUR2	hom	Verified	0.42138570189261	0.336736729091767	no	1609	0.345032100071601	1119	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|PROTEIN PHOSPHORYLATION|CHROMOSOME SEGREGATION	NUCLEUS		Cyclin for the Sgv1p (Bur1p) protein kinase; Sgv1p and Bur2p comprise a CDK-cyclin complex involved in transcriptional regulation through its phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II	phosphorylation of RNA polymerase II C-terminal domain|positive regulation of histone ubiquitination|transcription, DNA-dependent|positive regulation of histone H3-K4 methylation|mitotic sister chromatid segregation	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex|nucleus
YDR101C	YDR101C	ARX1	hom	Verified	0.421322308417315	0.336759871176518	no	1610	0.348084890188214	1142	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|PROTEOLYSIS	NUCLEUS	RIBOSOME	Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex	ribosomal large subunit biogenesis	molecular_function	nucleoplasm|cytosolic large ribosomal subunit|cytoplasm
YLR451W	YLR451W	LEU3	hom	Verified	0.419947464597298	0.337261916281544	no	1611	0.336298278625317	1096	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Zinc-knuckle transcription factor, repressor and activator; regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; acts as a repressor in leucine-replete conditions and as an activator in the presence of alpha-isopropylmalate, an intermediate in leucine biosynthesis that accumulates during leucine starvation	negative regulation of transcription from RNA polymerase II promoter|Unknown|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YFR056C_d	YFR056C	YFR056C	hom	Dubious	0.419383674335506	0.337467876732945	no	1612	0.330986780784264	1100	NA					Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W	Unknown	Unknown	Unknown
YGR061C	YGR061C	ADE6	hom	Verified	0.418474219653482	0.337800215847312	no	1613	0.324196348360991	1086	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM			Formylglycinamidine-ribonucleotide (FGAM)-synthetase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway	'de novo' IMP biosynthetic process|purine nucleotide biosynthetic process	phosphoribosylformylglycinamidine synthase activity	cytoplasm
YPR132W	YPR132W	RPS23B	hom	Verified	0.417118253796922	0.338295956962116	no	1614	0.313238601196937	1059	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23B has a paralog, RPS23A, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|regulation of translational fidelity	structural constituent of ribosome	cytosolic small ribosomal subunit
YDL021W	YDL021W	GPM2	hom	Verified	0.416781918054489	0.3384189647501	no	1615	0.345837369602126	1153	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event	biological_process	phosphoglycerate mutase activity|molecular_function	cytosol|cytoplasm
YHR113W	YHR113W	APE4	hom	Verified	0.416651054761373	0.338466829932806	no	1616	0.330481453215378	1140	NA	FT	PROTEOLYSIS			Cytoplasmic aspartyl aminopeptidase that may also function in the vacuole; CVT pathway cargo protein; cleaves unblocked N-terminal acidic amino acids from peptide substrates; forms a 12-subunit homo-oligomer; M18 metalloprotease family	proteolysis	aminopeptidase activity	fungal-type vacuole lumen|ribosome|cytoplasm
YGL143C	YGL143C	MRF1	hom	Verified	0.416552003364819	0.338503061179758	no	1617	0.38272597857995	1270	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial translation release factor, involved in stop codon recognition and hydrolysis of the peptidyl-tRNA bond during mitochondrial translation; lack of MRF1 causes mitochondrial genome instability	translational termination|mitochondrial translational termination|mitochondrial translation	translation release factor activity	mitochondrion
YGL215W	YGL215W	CLG1	hom	Verified	0.41630251333474	0.338594326839257	no	1618	0.353338096114837	1165	NA	FT	CELL CYCLE|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS			Cyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2	positive regulation of macroautophagy	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex
YFL053W	YFL053W	DAK2	hom	Verified	0.415977903279346	0.338713086258426	no	1619	0.328762652740732	1081	NA	FT	CARBOHYDRATE METABOLISM			Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation	response to stress|glycerol catabolic process	glycerone kinase activity	cellular_component
YCR044C	YCR044C	PER1	hom	Verified	0.415850515799722	0.338759695675954	no	1620	0.429837152663992	1372	NA	FF|FT	LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Protein of the endoplasmic reticulum, required for GPI-phospholipase A2 activity that remodels the GPI anchor as a prerequisite for association of GPI-anchored proteins with lipid rafts; functionally complemented by human ortholog PERLD1	GPI anchor biosynthetic process|cellular manganese ion homeostasis	molecular_function	fungal-type vacuole membrane|integral to membrane|endoplasmic reticulum
YFR014C	YFR014C	CMK1	hom	Verified	0.415843938613863	0.338762102249526	no	1621	0.320721259098974	1071	NA	FT	SIGNALING|PROTEIN PHOSPHORYLATION			Calmodulin-dependent protein kinase; may play a role in stress response, many Ca++/calmodulin dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK1 has a paralog, CMK2, that arose from the whole genome duplication	signal transduction|protein phosphorylation	protein kinase activity|calmodulin-dependent protein kinase activity	cytoplasm
YLL010C	YLL010C	PSR1	hom	Verified	0.415107902499247	0.339031457330864	no	1622	0.353367160549659	1194	NA	FT		PLASMA MEMBRANE		Plasma membrane associated protein phosphatase involved in the general stress response; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p	response to stress	phosphoprotein phosphatase activity	plasma membrane
YLR311C_d	YLR311C	YLR311C	hom	Dubious	0.414718483021508	0.339174000100769	no	1623	0.345821425951182	1170	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YHL044W_p	YHL044W	YHL044W	hom	Uncharacterized	0.41399792884043	0.339437811829332	no	1624	0.328159231327396	1127	NA	FT		PLASMA MEMBRANE		Putative integral membrane protein, member of DUP240 gene family; green fluorescent protein (GFP)-fusion protein localizes to the plasma membrane in a punctate pattern	biological_process	molecular_function	plasma membrane
YGR183C	YGR183C	QCR9	hom	Verified	0.413368552039568	0.339668305791184	no	1625	0.342558969892145	1153	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex	iron-sulfur cluster assembly|mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration	ubiquinol-cytochrome-c reductase activity	mitochondrion|integral to membrane|mitochondrial respiratory chain complex III
YCR102C_p	YCR102C	YCR102C	hom	Uncharacterized	0.413239947575342	0.339715411433584	no	1626	0.341089045701103	1139	NA	FT	OXIDATION-REDUCTION PROCESS			Putative protein of unknown function, involved in copper metabolism; similar to C. carbonum toxD gene; member of the quinone oxidoreductase family	response to copper ion	molecular_function	cellular_component
YOR322C	YOR322C	LDB19	hom	Verified	0.412793976672754	0.339878782429562	no	1627	0.372704101973006	1252	NA	FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION	GOLGI APPARATUS|PLASMA MEMBRANE		Protein involved in regulating the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target; inhibited by Npr1p-mediated phosphorylation, which affects translocation between the cytosol and the plasma membrane; null mutant has reduced affinity for alcian blue dye	ubiquitin-dependent endocytosis	ubiquitin protein ligase binding	cytosol|Golgi apparatus|plasma membrane|clathrin-coated vesicle|cytoplasm
YOR069W	YOR069W	VPS5	hom	Verified	0.412706273872296	0.339910913836615	no	1628	0.354137430839098	1177	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Nexin-1 homolog required for localizing membrane proteins from a prevacuolar/late endosomal compartment back to the late Golgi apparatus; structural component of the retromer membrane coat complex; forms a retromer subcomplex with Vps17p; required for recruiting the retromer complex to the endosome membranes	protein retention in Golgi apparatus|retrograde transport, endosome to Golgi	protein transporter activity|phosphatidylinositol-3-phosphate binding	cytosol|endosome|retromer complex, outer shell|retromer complex
YDR524C-B_p	YDR524C-B	YDR524C-B	hom	Uncharacterized	0.412396953707433	0.340024247803513	no	1629	0.359273313063045	1248	NA	FT		PLASMA MEMBRANE		Putative protein of unknown function; YDR524C-B has a paralog, YCL048W-A, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YLR104W_p	YLR104W	LCL2	hom	Uncharacterized	0.41238315373535	0.340029304408251	no	1630	0.342887318036744	1115	NA	FT	PROTEOLYSIS			Putative protein of unknown function; mutant is deficient in amounts of cell wall mannosylphosphate and has long chronological lifespan; genetic interactions suggest a role in ER-associated protein degradation (ERAD)	ER-associated protein catabolic process	molecular_function	cellular_component
YBR281C	YBR281C	DUG2	hom	Verified	0.412209756406657	0.34009284334792	no	1631	0.330657083510037	1130	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|PROTEOLYSIS	NUCLEUS		Component of glutamine amidotransferase (GATase II); forms a complex with Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)	glutathione catabolic process	peptidase activity|gamma-glutamyltransferase activity|omega peptidase activity	nucleus|cytoplasm
YML099C	YML099C	ARG81	hom	Verified	0.411115432180983	0.340493947324061	no	1632	0.333890631855453	1156	NA	FT	VESICLE-MEDIATED TRANSPORT|TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type, involved in the regulation of arginine-responsive genes; acts with Arg80p and Arg82p	arginine metabolic process|negative regulation of calcium ion-dependent exocytosis	transcription cofactor activity	nucleus
YHR125W_d	YHR125W	YHR125W	hom	Dubious	0.410571464866471	0.340693395503097	no	1633	0.346649613103165	1191	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKR010C	YKR010C	TOF2	hom	Verified	0.409715622014453	0.34100728448215	no	1634	0.328140002111973	1121	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CHROMOSOME SEGREGATION|GENE SILENCING	NUCLEUS|MITOCHONDRION		Protein required for rDNA silencing and mitotic rDNA condensation; stimulates Cdc14p phosphatase activity and biphasic release to promote rDNA repeat segregation; required for condensin recruitment to the replication fork barrier site; TOF2 has a paralog, NET1, that arose from the whole genome duplication	nucleolus organization|rDNA condensation|chromatin silencing at rDNA|protein localization to nucleolar rDNA repeats	phosphatase activator activity	mitochondrion|nucleolus
YCR087C-A_p	YCR087C-A	YCR087C-A	hom	Uncharacterized	0.408822599533009	0.341334926824037	no	1635	0.351675698189569	1181	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YCR087C-A is not an essential gene	biological_process	molecular_function	nucleolus
YLR420W	YLR420W	URA4	hom	Verified	0.408574711268346	0.341425896140517	no	1636	0.350717096575523	1187	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate	'de novo' pyrimidine nucleobase biosynthetic process|pyrimidine nucleotide biosynthetic process	dihydroorotase activity	nucleus|cytoplasm
YFL056C	YFL056C	AAD6	hom	Verified	0.408220367379514	0.341555948231016	no	1637	0.335510050770498	1133	NA	FT	OXIDATION-REDUCTION PROCESS			Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin	cellular aldehyde metabolic process	aryl-alcohol dehydrogenase (NAD+) activity	cellular_component
YPL071C_p	YPL071C	YPL071C	hom	Uncharacterized	0.407993842240432	0.341639097855426	no	1638	0.324199634590678	1092	NA	FT		NUCLEUS		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	biological_process	molecular_function	nucleus|cytoplasm
YJR056C	YJR056C	YJR056C	hom	Verified	0.407540722349844	0.341805445714273	no	1639	0.29825010732065	1035	NA	FT		NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YDR030C	YDR030C	RAD28	hom	Verified	0.407420330480274	0.341849648741617	no	1640	0.343243628548202	1142	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Protein involved in DNA repair, related to the human CSA protein that is involved in transcription-coupled repair nucleotide excision repair	DNA repair	molecular_function	nucleus
YHL042W_p	YHL042W	YHL042W	hom	Uncharacterized	0.407413316926475	0.341852223901871	no	1641	0.314436098423272	1046	NA					Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins	biological_process	molecular_function	cellular_component
YDL237W	YDL237W	AIM6	hom	Verified	0.407255837431935	0.341910047443851	no	1642	0.346237077253777	1151	NA					Putative protein of unknown function, required for respiratory growth; YDL237W is not an essential gene	biological_process	molecular_function	cellular_component
YML006C	YML006C	GIS4	hom	Verified	0.405607857112112	0.342515377415862	no	1643	0.346609628202837	1137	NA	FT	SIGNALING|ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		CAAX box containing protein of unknown function, proposed to be involved in the RAS/cAMP signaling pathway	cellular ion homeostasis|intracellular signal transduction	molecular_function	plasma membrane
YEL064C	YEL064C	AVT2	hom	Verified	0.404389271037275	0.342963244278747	no	1644	0.321889576468158	1092	NA	FT		ENDOPLASMIC RETICULUM		Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters	transport	transporter activity	integral to membrane|endoplasmic reticulum
YDR142C	YDR142C	PEX7	hom	Verified	0.40419480042974	0.343034738489216	no	1645	0.369132327652338	1198	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PEROXISOME ORGANIZATION			Peroxisomal signal receptor for the N-terminal nonapeptide signal (PTS2) of peroxisomal matrix proteins; WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodysplasia punctata (RCDP)	protein import into peroxisome matrix, docking	peroxisome matrix targeting signal-2 binding	cytosol|peroxisome
YDR492W	YDR492W	IZH1	hom	Verified	0.403711667257543	0.3432123794938	no	1646	0.339668917488582	1162	NA	FT	LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc	response to zinc ion|cellular zinc ion homeostasis|cellular lipid metabolic process	metal ion binding	integral to membrane|endoplasmic reticulum|membrane
YOR366W_d	YOR366W	YOR366W	hom	Dubious	0.402587295036806	0.34362592882275	no	1647	0.35256114555226	1183	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C	Unknown	Unknown	Unknown
YJL071W	YJL071W	ARG2	hom	Verified	0.401691830414965	0.343955418834113	no	1648	0.331744061631	1111	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Acetylglutamate synthase (glutamate N-acetyltransferase), mitochondrial enzyme that catalyzes the first step in the biosynthesis of the arginine precursor ornithine; forms a complex with Arg5,6p	arginine biosynthetic process|ornithine biosynthetic process	acetyl-CoA:L-glutamate N-acetyltransferase activity	mitochondrial matrix
YGR025W_d	YGR025W	YGR025W	hom	Dubious	0.401174621069748	0.344145782230056	no	1649	0.32268880753295	1086	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKL185W	YKL185W	ASH1	hom	Verified	0.400650383261444	0.344338772824449	no	1650	0.31657904087698	1093	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate	Unknown	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|core promoter proximal region sequence-specific DNA binding	Rpd3L-Expanded complex|nucleus|cellular bud|Rpd3L complex
YNL328C	YNL328C	MDJ2	hom	Verified	0.400599276128967	0.344357589348184	no	1651	0.363218127732769	1217	NA	FT	PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Constituent of the mitochondrial import motor associated with the presequence translocase; function overlaps with that of Pam18p; stimulates the ATPase activity of Ssc1p to drive mitochondrial import; contains a J domain	protein import into mitochondrial matrix	protein transporter activity|ATPase activator activity	mitochondrial inner membrane|presequence translocase-associated import motor
YOR188W	YOR188W	MSB1	hom	Verified	0.398060752360304	0.345292702003112	no	1652	0.388783272921244	1318	NA	FT		MITOCHONDRION|SITE OF POLARIZED GROWTH		Protein of unknown function; may be involved in positive regulation of 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4; potential Cdc28p substrate; relocalizes from bud neck to cytoplasm upon DNA replication stress	establishment of cell polarity	molecular_function	mitochondrion|cellular bud neck|cellular bud tip
YAL031C	YAL031C	GIP4	hom	Verified	0.397759159054734	0.345403862462404	no	1653	0.336607874041612	1114	NA	FT	CHROMOSOME SEGREGATION			Cytoplasmic Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; potential Cdc28p substrate	chromosome segregation|regulation of phosphoprotein phosphatase activity	protein phosphatase 1 binding|protein phosphatase type 1 regulator activity	cytoplasm
YLR283W_p	YLR283W	YLR283W	hom	Uncharacterized	0.397288611007891	0.345577322442749	no	1654	0.330290657733245	1132	NA	FT		MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR283W is not an essential gene	biological_process	molecular_function	mitochondrion
YOR247W	YOR247W	SRL1	hom	Verified	0.396869320561195	0.345731914456616	no	1655	0.348413500294159	1149	NA	FT	CELL WALL ORG/BIOGENESIS	SITE OF POLARIZED GROWTH		Mannoprotein that exhibits a tight association with the cell wall; required for cell wall stability in the absence of GPI-anchored mannoproteins; has a high serine-threonine content; expression is induced in cell wall mutants; SRL1 has a paralog, SVS1, that arose from the whole genome duplication	fungal-type cell wall organization|nucleobase-containing compound metabolic process	molecular_function	fungal-type cell wall|fungal-type vacuole|cytoplasm|cellular bud tip
YDR340W_d	YDR340W	YDR340W	hom	Dubious	0.396122215205209	0.346007435281241	no	1656	0.329540272928363	1094	NA					Putative protein of unknown function	Unknown	Unknown	Unknown
YAR050W	YAR050W	FLO1	hom	Verified	0.396064083559688	0.346028876748385	no	1657	0.361044000055957	1179	NA	FT		PLASMA MEMBRANE		Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p	cellular response to stress|flocculation via cell wall protein-carbohydrate interaction|flocculation	mannose binding	fungal-type cell wall
YPL263C	YPL263C	KEL3	hom	Verified	0.39575018984556	0.346144662865529	no	1658	0.324285639298701	1064	NA					Cytoplasmic protein of unknown function	biological_process	molecular_function	cytoplasm
YDL127W	YDL127W	PCL2	hom	Verified	0.395661384087522	0.346177423296761	no	1659	0.297789442588784	1025	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	NUCLEUS|SITE OF POLARIZED GROWTH		Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; localizes to sites of polarized cell growth	G1 phase of mitotic cell cycle|regulation of establishment or maintenance of cell polarity|regulation of cyclin-dependent protein kinase activity|septin ring organization	cyclin-dependent protein kinase regulator activity	cyclin-dependent protein kinase holoenzyme complex|incipient cellular bud site|nucleus|cellular bud neck|cellular bud tip
YBL011W	YBL011W	SCT1	hom	Verified	0.394607401554732	0.346566325143666	no	1660	0.340365819816181	1147	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase of the glycerolipid biosynthesis pathway, prefers 16-carbon fatty acids, similar to Gpt2p, gene is constitutively transcribed	phospholipid biosynthetic process	glycerol-3-phosphate O-acyltransferase activity|glycerone-phosphate O-acyltransferase activity	integral to membrane|endoplasmic reticulum
YBR250W	YBR250W	SPO23	hom	Verified	0.394432359137114	0.346630928529949	no	1661	0.350673366784752	1152	NA	FT	CELL CYCLE			Protein of unknown function; associates with meiosis-specific protein Spo1p	meiosis	molecular_function	cellular_component
YIL032C_d	YIL032C	YIL032C	hom	Dubious	0.393263963604712	0.347062265655605	no	1662	0.357205048691739	1185	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOR177C	YOR177C	MPC54	hom	Verified	0.3920194183748	0.347521933029847	no	1663	0.356834983393453	1190	NA	FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION	NUCLEUS|CYTOSKELETON		Component of the meiotic outer plaque, a membrane-organizing center which is assembled on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; potential Cdc28p substrate	ascospore wall assembly|vesicle docking	structural molecule activity	spindle pole body
YMR303C	YMR303C	ADH2	hom	Verified	0.391904848017954	0.347564260378354	no	1664	0.341905750250462	1137	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM			Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1	ethanol metabolic process|NADH oxidation|fermentation|amino acid catabolic process to alcohol via Ehrlich pathway	alcohol dehydrogenase (NAD) activity	cytoplasm
YGL156W	YGL156W	AMS1	hom	Verified	0.391177289723708	0.347833096873267	no	1665	0.349507144108315	1179	NA	FT	CARBOHYDRATE METABOLISM			Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway	oligosaccharide catabolic process|cellular carbohydrate metabolic process	alpha-mannosidase activity	fungal-type vacuole membrane
YBR045C	YBR045C	GIP1	hom	Verified	0.390438407976052	0.348106195759874	no	1666	0.357992073880768	1191	NA	FT	CELL WALL ORG/BIOGENESIS			Meiosis-specific regulatory subunit of the Glc7p protein phosphatase, regulates spore wall formation and septin organization, required for expression of some late meiotic genes and for normal localization of Glc7p	ascospore wall assembly|regulation of phosphoprotein phosphatase activity	protein phosphatase type 1 regulator activity|protein phosphatase 1 binding	protein phosphatase type 1 complex|prospore membrane
YGL037C	YGL037C	PNC1	hom	Verified	0.390392841614008	0.348123040173335	no	1667	0.330458811302076	1099	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|GENE SILENCING	NUCLEUS		Nicotinamidase that converts nicotinamide to nicotinic acid; part of the NAD(+) salvage pathway; required for life span extension by calorie restriction; PNC1 expression responds to all known stimuli that extend replicative life span; protein increases in abundance and relative distribution to cytoplasmic foci decreases upon DNA replication stress	replicative cell aging|chromatin silencing at rDNA|nicotinate nucleotide salvage|chromatin silencing at telomere	nicotinamidase activity	nucleus|peroxisome|cytoplasm
YPL060W	YPL060W	MFM1	hom	Verified	0.389946720788066	0.348287972468309	no	1668	0.366743143606319	1210	NA	FT	RNA PROCESSING|ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Mitochondrial inner membrane magnesium transporter, involved in maintenance of mitochondrial magnesium concentrations and membrane potential; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p	mitochondrial magnesium ion transport	magnesium ion transmembrane transporter activity	integral to membrane|mitochondrial inner membrane
YLR257W	YLR257W	YLR257W	hom	Verified	0.389023124558862	0.348629520110846	no	1669	0.351152027127758	1155	NA					Protein of unknown function; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	cytoplasm
YLR285W	YLR285W	NNT1	hom	Verified	0.388918066238251	0.34866837865715	no	1670	0.336233755575708	1121	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|GENE SILENCING			S-adenosylmethionine-dependent methyltransferase; has a role in rDNA silencing and in lifespan determination	chromatin silencing at rDNA|nicotinamide metabolic process	S-adenosylmethionine-dependent methyltransferase activity|nicotinamide N-methyltransferase activity	cytoplasm
YBR275C	YBR275C	RIF1	hom	Verified	0.388490084358193	0.348826695267289	no	1671	0.331795466667321	1103	NA	FT	CELL CYCLE|GENE SILENCING	NUCLEUS|CHROMOSOME		Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation	telomere capping|telomere maintenance|chromatin silencing at silent mating-type cassette	telomeric DNA binding	nuclear telomere cap complex
YNL092W_p	YNL092W	YNL092W	hom	Uncharacterized	0.388117927512898	0.348964382798871	no	1672	0.335903700243883	1113	NA					Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; YNL092W is not an essential gene	biological_process	S-adenosylmethionine-dependent methyltransferase activity	cellular_component
YIL037C	YIL037C	PRM2	hom	Verified	0.387523087924969	0.349184497955855	no	1673	0.35378717298394	1188	NA					Pheromone-regulated protein, predicted to have 4 transmembrane segments and a coiled coil domain; regulated by Ste12p; required for efficient nuclear fusion	karyogamy involved in conjugation with cellular fusion	molecular_function	integral to membrane
YGR008C	YGR008C	STF2	hom	Verified	0.385990530940782	0.349751840820021	no	1674	0.352317297132789	1197	NA	FT		MITOCHONDRION		Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress	cellular response to desiccation	molecular_function	cytoplasm
YLR389C	YLR389C	STE23	hom	Verified	0.385831712998262	0.349810653430713	no	1675	0.336613903848427	1148	NA	FT	PROTEOLYSIS			Metalloprotease involved, with homolog Axl1p, in N-terminal processing of pro-a-factor to the mature form; expressed in both haploids and diploids; member of the insulin-degrading enzyme family	peptide pheromone maturation	metallopeptidase activity|metalloendopeptidase activity	extrinsic to membrane
YGL057C	YGL057C	GEP7	hom	Verified	0.384921875788339	0.350147648902663	no	1676	0.362570498254421	1208	NA	FT		MITOCHONDRION		Protein of unknown function; null mutant exhibits a respiratory growth defect and synthetic interactions with prohibitin (phb1) and gem1; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YPL038W	YPL038W	MET31	hom	Verified	0.384240566094895	0.35040007715473	no	1677	0.347159319960559	1202	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; MET31 has a paralog, MET32, that arose from the whole genome duplication	regulation of sulfur amino acid metabolic process|regulation of transcription from RNA polymerase II promoter	core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity	nucleus|cytoplasm
YGR087C	YGR087C	PDC6	hom	Verified	0.384054000836685	0.350469211938398	no	1678	0.356858048695286	1187	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation	L-phenylalanine catabolic process|ethanol metabolic process|tryptophan catabolic process|aromatic amino acid family catabolic process to alcohol via Ehrlich pathway	pyruvate decarboxylase activity	cytoplasm
YLR328W	YLR328W	NMA1	hom	Verified	0.383616405460433	0.350631389438216	no	1679	0.37624907740154	1232	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	NUCLEUS		Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways; NMA1 has a paralog, NMA2, that arose from the whole genome duplication	NAD biosynthetic process	nicotinamide-nucleotide adenylyltransferase activity	nucleus|cytoplasm
YGR010W	YGR010W	NMA2	hom	Verified	0.383542438066352	0.350658805231807	no	1680	0.357949630256704	1181	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	NUCLEUS		Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in de novo and salvage synthesis of NAD(+); NMA2 has a paralog, NMA1, that arose from the whole genome duplication	NAD biosynthetic process	nicotinamide-nucleotide adenylyltransferase activity	nucleus
YDR453C	YDR453C	TSA2	hom	Verified	0.383139182102093	0.350808284525581	no	1681	0.340807065300381	1129	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS			Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants; protein abundance increases in response to DNA replication stress	cellular response to oxidative stress|cell redox homeostasis	peroxiredoxin activity|thioredoxin peroxidase activity	cytoplasm
YOL137W	YOL137W	BSC6	hom	Verified	0.382275953860574	0.35112834438201	no	1682	0.367200488572653	1235	NA	FT		GOLGI APPARATUS		Protein of unknown function containing 8 putative transmembrane seqments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression	biological_process	molecular_function	COPI-coated vesicle|integral to membrane|clathrin-coated vesicle
YMR067C	YMR067C	UBX4	hom	Verified	0.381393374132407	0.351455688416807	no	1683	0.375823751394781	1246	NA	FT	PROTEOLYSIS	NUCLEUS		UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the Cdc48p-Nplp-Ufd1p AAA ATPase complex during its role in delivery of misfolded proteins to the proteasome; protein abundance increases in response to DNA replication stress	ER-associated protein catabolic process|sporulation resulting in formation of a cellular spore	protein complex binding	nucleus|cytoplasm|extrinsic to membrane
YFL044C	YFL044C	OTU1	hom	Verified	0.37996397167068	0.351986079721566	no	1684	0.333425700973867	1127	NA	FT	PROTEOLYSIS	NUCLEUS		Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family; protein abundance increases in response to DNA replication stress	protein deubiquitination|regulation of transcription, DNA-dependent	ubiquitin-specific protease activity	nucleus|cytoplasm
YJL042W	YJL042W	MHP1	hom	Verified	0.378727094202027	0.352445265653166	no	1685	0.342810979889879	1151	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	CYTOSKELETON		Microtubule-associated protein involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; similar to Drosophila protein MAP and to mammalian MAP4 proteins	fungal-type cell wall organization|negative regulation of microtubule depolymerization	structural constituent of cytoskeleton	microtubule
YML087C	YML087C	AIM33	hom	Verified	0.378397015227352	0.35256784257807	no	1686	0.345217465543608	1118	NA	FT	OXIDATION-REDUCTION PROCESS			Putative protein of unknown function, highly conserved across species; homolog of human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss; AIM33 has a paralog, PGA3, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YGL202W	YGL202W	ARO8	hom	Verified	0.377721168866232	0.352818870176177	no	1687	0.343082851648	1152	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis	aromatic amino acid family metabolic process	aromatic-amino-acid:2-oxoglutarate aminotransferase activity|2-aminoadipate transaminase activity	cytoplasm
YDR149C_d	YDR149C	YDR149C	hom	Dubious	0.377309669535978	0.352971743542474	no	1688	0.351965291140139	1187	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene NUM1; null mutation blocks anaerobic growth	Unknown	Unknown	Unknown
YKR009C	YKR009C	FOX2	hom	Verified	0.377077916675706	0.353057850949209	no	1689	0.323913295338485	1101	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS			Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities	fatty acid beta-oxidation	enoyl-CoA hydratase activity|3-hydroxyacyl-CoA dehydrogenase activity	peroxisome
YGR256W	YGR256W	GND2	hom	Verified	0.376872404376401	0.35313421501269	no	1690	0.343351681008748	1173	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS			6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone; GND2 has a paralog, GND1, that arose from the whole genome duplication	pentose-phosphate shunt, oxidative branch	phosphogluconate dehydrogenase (decarboxylating) activity	cytosol|plasma membrane
YDR503C	YDR503C	LPP1	hom	Verified	0.37686010597828	0.35313878502729	no	1691	0.342288247284719	1143	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Lipid phosphate phosphatase, catalyzes Mg(2+)-independent dephosphorylation of phosphatidic acid (PA), lysophosphatidic acid, and diacylglycerol pyrophosphate; involved in control of the cellular levels of phosphatidylinositol and PA	phospholipid metabolic process	phosphatidate phosphatase activity	integral to membrane|membrane
YGL010W_p	YGL010W	YGL010W	hom	Uncharacterized	0.376799486087333	0.353161311342523	no	1692	0.355014764252428	1169	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative protein of unknown function; YGL010W is not an essential gene	biological_process	molecular_function	integral to membrane|endoplasmic reticulum
YIL034C	YIL034C	CAP2	hom	Verified	0.374941850979835	0.353851856572372	no	1693	0.276540352540822	989	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Beta subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress	barbed-end actin filament capping|filamentous growth	actin filament binding	actin filament|F-actin capping protein complex|mating projection tip|actin cortical patch
YGL041C-B_p	YGL041C-B	YGL041C-B	hom	Uncharacterized	0.374770818576513	0.35391545926851	no	1694	0.345193918563251	1152	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YKL106W	YKL106W	AAT1	hom	Verified	0.374144203988026	0.354148516464333	no	1695	0.341621376010006	1156	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis	aspartate catabolic process|chronological cell aging|replicative cell aging|asparagine biosynthetic process from oxaloacetate|aspartate biosynthetic process	L-aspartate:2-oxoglutarate aminotransferase activity	mitochondrion
YHR104W	YHR104W	GRE3	hom	Verified	0.373911287532992	0.35423515917725	no	1696	0.353943484674108	1156	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Aldose reductase; involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress	galactose catabolic process|cellular response to oxidative stress|arabinose catabolic process|D-xylose catabolic process|response to stress	D-xylose:NADP reductase activity|mRNA binding|glucose 1-dehydrogenase (NADP+) activity|alditol:NADP+ 1-oxidoreductase activity	nucleus|cytoplasm
YPL232W	YPL232W	SSO1	hom	Verified	0.373822819186533	0.354268070540992	no	1697	0.359509072682625	1224	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	PLASMA MEMBRANE		Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p	ascospore formation|ascospore-type prospore assembly|vesicle fusion	phosphatidic acid binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|SNAP receptor activity	SNARE complex|fungal-type vacuole membrane|plasma membrane|prospore membrane
YBR019C	YBR019C	GAL10	hom	Verified	0.372033766815463	0.354933854314308	no	1698	0.351540136892388	1170	NA	FT	CARBOHYDRATE METABOLISM			UDP-glucose-4-epimerase, catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes the conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers	galactose catabolic process via UDP-galactose	aldose 1-epimerase activity|UDP-glucose 4-epimerase activity	cytosol
YBR174C_d	YBR174C	YBR174C	hom	Dubious	0.371843055714718	0.355004852341884	no	1699	0.358357037765587	1189	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YBR175W; null mutant is viable and sporulation defective	Unknown	Unknown	Unknown
YBR138C_p	YBR138C	YBR138C	hom	Uncharacterized	0.371519751679525	0.35512522363751	no	1700	0.308619619784919	1041	NA					Cytoplasmic protein of unknown function, potentially phosphorylated by Cdc28p; YBR138C is not an essential gene	biological_process	molecular_function	cytoplasm
YLR172C	YLR172C	DPH5	hom	Verified	0.370980785155953	0.355325921686763	no	1701	0.370832502226393	1226	NA					Methyltransferase required for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); not essential for viability; GFP-Dph5p fusion protein localizes to the cytoplasm	peptidyl-diphthamide biosynthetic process from peptidyl-histidine	diphthine synthase activity	cytoplasm
YFL030W	YFL030W	AGX1	hom	Verified	0.370176927142314	0.355625333447696	no	1702	0.352265619072466	1171	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases	glycine biosynthetic process, by transamination of glyoxylate	alanine-glyoxylate transaminase activity	mitochondrion
YML005W	YML005W	TRM12	hom	Verified	0.369960115159799	0.355706104339275	no	1703	0.386131168295962	1286	NA	FT	RNA PROCESSING			S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; required for wybutosine formation in phenylalanine-accepting tRNA	wybutosine biosynthetic process|tRNA methylation	S-adenosylmethionine-dependent methyltransferase activity|transferase activity, transferring alkyl or aryl (other than methyl) groups	cytoplasm
YBR268W	YBR268W	MRPL37	hom	Verified	0.369027749128982	0.356053520727658	no	1704	0.384707538934913	1266	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YCR088W	YCR088W	ABP1	hom	Verified	0.368855925553172	0.356117558343257	no	1705	0.34841496770524	1131	NA	FT	PROTEIN LOCALIZATION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization; phosphorylation within its PRR (Proline-Rich Region), mediated by Cdc28p and Pho85p, protects Abp1p from proteolysis mediated by its own PEST sequences	protein localization|actin cortical patch assembly	actin filament binding	cell cortex|mating projection tip|cytoplasm|actin cortical patch
YDR479C	YDR479C	PEX29	hom	Verified	0.368693919925585	0.356177940585966	no	1706	0.366131688532372	1242	NA	FT	PEROXISOME ORGANIZATION			Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress	peroxisome organization	molecular_function	integral to membrane|peroxisomal membrane
YML084W_d	YML084W	YML084W	hom	Dubious	0.368536442519459	0.356236638540774	no	1707	0.332706655780727	1137	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YOL037C_d	YOL037C	YOL037C	hom	Dubious	0.367883690792114	0.356479980812688	no	1708	0.370617196075216	1218	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOL036W	Unknown	Unknown	Unknown
YJR133W	YJR133W	XPT1	hom	Verified	0.367867007560115	0.356486200996596	no	1709	0.364369505186294	1203	NA	FT	NUCLEOTIDE METABOLISM			Xanthine-guanine phosphoribosyl transferase, required for xanthine utilization and for optimal utilization of guanine	XMP salvage|hypoxanthine metabolic process	xanthine phosphoribosyltransferase activity|hypoxanthine phosphoribosyltransferase activity	cytoplasm
YKL066W_d	YKL066W	YKL066W	hom	Dubious	0.367741509829155	0.356532992852016	no	1710	0.313906063334541	1079	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species; partially overlaps the verified gene YNK1	Unknown	Unknown	Unknown
YFR026C	YFR026C	ULI1	hom	Verified	0.367153895517813	0.356752113689469	no	1711	0.358852035606667	1210	NA	FT	SIGNALING			Putative protein of unknown function involved in and induced by the endoplasmic reticulum unfolded protein response	endoplasmic reticulum unfolded protein response	molecular_function	cellular_component
YGL200C	YGL200C	EMP24	hom	Verified	0.366147981092995	0.3571273279624	no	1712	0.367321718695804	1241	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles	protein retention in ER lumen|vesicle organization|ER to Golgi vesicle-mediated transport	molecular_function	integral to membrane|endoplasmic reticulum|ER to Golgi transport vesicle
YLR184W_d	YLR184W	YLR184W	hom	Dubious	0.364287711525868	0.357821587586707	no	1713	0.331660111045749	1142	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YPL196W	YPL196W	OXR1	hom	Verified	0.364083332297115	0.357897891418009	no	1714	0.348669968814084	1194	NA	FT	RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		Protein of unknown function required for normal levels of resistance to oxidative damage, null mutants are sensitive to hydrogen peroxide; member of a conserved family of proteins found in eukaryotes	cellular response to oxidative stress	molecular_function	mitochondrion
YDR249C_p	YDR249C	YDR249C	hom	Uncharacterized	0.363309949608356	0.358186680851142	no	1715	0.365383628408564	1199	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YIR042C_p	YIR042C	YIR042C	hom	Uncharacterized	0.36284662712488	0.358359729343439	no	1716	0.348817639460934	1130	NA					Putative protein of unknown function; YIR042C is a non-essential gene	biological_process	molecular_function	cellular_component
YCL034W	YCL034W	LSB5	hom	Verified	0.362320994428943	0.358556085594924	no	1717	0.371474593529075	1205	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION	CYTOSKELETON		Protein of unknown function; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; may mediate disassembly of the Pan1 complex from the endocytic coat	endocytosis|actin filament organization|actin cortical patch localization|actin cytoskeleton organization	molecular_function	cell cortex|cytoplasm|actin cortical patch
YAL056W	YAL056W	GPB2	hom	Verified	0.361995382481685	0.358677740514975	no	1718	0.356832082193249	1184	NA	FT	TRANSCRIPTION FROM RNA POL II|SIGNALING	MITOCHONDRION|PLASMA MEMBRANE		Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; GPB2 has a paralog, GPB1, that arose from the whole genome duplication	signal transduction|glucose mediated signaling pathway|pseudohyphal growth|ascospore formation|negative regulation of Ras protein signal transduction|invasive growth in response to glucose limitation|positive regulation of transcription from RNA polymerase II promoter	cAMP-dependent protein kinase inhibitor activity|signal transducer activity|GTPase activating protein binding	mitochondrion|plasma membrane|cytoplasm
YDR239C	YDR239C	YDR239C	hom	Verified	0.361426773988125	0.358890218023347	no	1719	0.361338800956372	1194	NA					Protein of unknown function that may interact with ribosomes, based on co-purification experiments	biological_process	molecular_function	ribosome|cytoplasm
YBR278W	YBR278W	DPB3	hom	Verified	0.36091431307255	0.35908175173294	no	1720	0.365705452440211	1232	NA	FT	RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS|CHROMOSOME		Third-largest subunit of DNA polymerase II (DNA polymerase epsilon); required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; mRNA abundance peaks at the G1/S boundary of the cell cycle; DPB3 has a paralog, DLS1, that arose from the whole genome duplication	DNA-dependent DNA replication|chromatin silencing at telomere	double-stranded DNA binding|single-stranded DNA binding|DNA-directed DNA polymerase activity	epsilon DNA polymerase complex
YPR003C_p	YPR003C	YPR003C	hom	Uncharacterized	0.360799903616732	0.359124517428315	no	1721	0.350060337203611	1167	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative sulfate permease; physically interacts with Hsp82p; green fluorescent protein (GFP)-fusion protein localizes to the ER; YPR003C is not an essential gene	biological_process	molecular_function	integral to membrane|endoplasmic reticulum
YJL082W	YJL082W	IML2	hom	Verified	0.360688006390498	0.359166345772192	no	1722	0.338292802393249	1129	NA	FT		NUCLEUS|MITOCHONDRION		Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; IML2 has a paralog, YKR018C, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrial outer membrane|mitochondrion|nucleus|cytoplasm
YOL092W	YOL092W	YPQ1	hom	Verified	0.360400826658723	0.35927370426007	no	1723	0.352465810496506	1163	NA					Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter	biological_process	molecular_function	fungal-type vacuole membrane|integral to membrane|cytoplasm
YNL099C	YNL099C	OCA1	hom	Verified	0.359926767879651	0.359450949409387	no	1724	0.374713025658922	1246	NA	FF|FT	RESPONSE TO OXIDATIVE STRESS			Putative protein tyrosine phosphatase, required for cell cycle arrest in response to oxidative damage of DNA	cellular response to oxidative stress	protein tyrosine phosphatase activity	cytoplasm
YDL117W	YDL117W	CYK3	hom	Verified	0.358866249050588	0.359847574718625	no	1725	0.352798318932265	1185	NA	FT	CELL CYCLE|CELL DIVISION	SITE OF POLARIZED GROWTH|CYTOSKELETON		SH3-domain protein located in the bud neck and cytokinetic actin ring; relocalizes from bud neck to nucleus upon DNA replication stress; activates the chitin synthase activity of Chs2p during cytokinesis; suppressor of growth and cytokinesis defects of chs2 phospho-mutants	barrier septum assembly involved in cell cycle cytokinesis|cytokinesis	molecular_function	cellular bud neck contractile ring|cellular bud neck|cytoplasm
YDR432W	YDR432W	NPL3	hom	Verified	0.358639786058032	0.359932289588403	no	1726	0.383589743344435	1287	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION	NUCLEUS		RNA-binding protein; promotes elongation, regulates termination, and carries poly(A) mRNA from nucleus to cytoplasm; has a role in repressing translation initiation by binding eIF4G; required for pre-mRNA splicing; dissociation from mRNAs promoted by Mtr10p; phosphorylated by Sky1p in the cytoplasm; protein abundance increases in response to DNA replication stress	translational termination|mRNA export from nucleus|negative regulation of translation|mRNA splicing, via spliceosome|Unknown|positive regulation of transcription elongation from RNA polymerase II promoter	mRNA binding|RNA polymerase II core binding|eukaryotic initiation factor 4G binding|poly(A) RNA binding	nucleus|cytoplasm
YPL061W	YPL061W	ALD6	hom	Verified	0.357521949719072	0.360350548532035	no	1727	0.350844078207849	1179	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress	response to salt stress|NADPH regeneration|acetate biosynthetic process	aldehyde dehydrogenase [NAD(P)+] activity	cytosol|mitochondrion
YGR014W	YGR014W	MSB2	hom	Verified	0.356460759646145	0.360747766941756	no	1728	0.377934542757758	1260	NA	FT	SIGNALING	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Mucin family member involved in signaling; functions in the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; is processed into secreted and cell-associated forms by the aspartyl protease, Yps1p; also functions as an osmosensor in parallel to the Sho1p-mediated pathway; potential Cdc28p substrate	signal transduction involved in filamentous growth|osmosensory signaling pathway via Sho1 osmosensor|establishment of cell polarity|hyperosmotic response|response to osmotic stress	osmosensor activity	site of polarized growth|integral to plasma membrane
YOR253W	YOR253W	NAT5	hom	Verified	0.356161819606077	0.360859691562359	no	1729	0.363944056471799	1201	NA	FT			RIBOSOME	Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing	N-terminal protein amino acid acetylation	peptide alpha-N-acetyltransferase activity	NatA complex|cytosolic ribosome
YKL133C_p	YKL133C	YKL133C	hom	Uncharacterized	0.355522279433543	0.361099178555626	no	1730	0.374527251638431	1236	NA					Putative protein of unknown function; has similarity to Mgr3p, but unlike MGR3, is not required for growth of cells lacking the mitochondrial genome (null mutation does not confer a petite-negative phenotype)	biological_process	molecular_function	cellular_component
YMR020W	YMR020W	FMS1	hom	Verified	0.355253813033231	0.361199726724011	no	1731	0.33423501611149	1107	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM			Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis	pantothenate biosynthetic process|polyamine catabolic process	polyamine oxidase activity	cytoplasm
YOR191W	YOR191W	ULS1	hom	Verified	0.354795990102867	0.361371216322272	no	1732	0.34824731132474	1163	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS|MITOCHONDRION		Protein involved in proteolytic control of sumoylated substrates; contains RING finger domain; interacts with SUMO (Smt3p); member of the SWI/SNF family of DNA-dependent ATPases; plays a role in antagonizing silencing during mating-type switching; relocalizes from nucleus to cytoplasm upon DNA replication stress	chromatin assembly or disassembly|mating type switching	SUMO binding|DNA-dependent ATPase activity	mitochondrion|nucleolus|nucleus
YPL221W	YPL221W	FLC1	hom	Verified	0.353251431994235	0.361949976459196	no	1733	0.357990673182008	1177	NA	FT	CELL WALL ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH		Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance	protein folding|fungal-type cell wall biogenesis|FAD transport	FAD transmembrane transporter activity	integral to membrane|endoplasmic reticulum|fungal-type vacuole|cellular bud neck
YLR374C_d	YLR374C	YLR374C	hom	Dubious	0.351218112804727	0.362712361288813	no	1734	0.407902635336891	1337	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF STP3/YLR375W	Unknown	Unknown	Unknown
YGR146C	YGR146C	ECL1	hom	Verified	0.350862424924128	0.362845781073488	no	1735	0.372858875256347	1221	NA					Protein of unknown function; mitochondrial-dependent role in the extension of chronological lifespan; overexpression increases oxygen consumption and respiratory activity while deletion results in reduced oxygen consumption under conditions of caloric restriction; induced by iron homeostasis transcription factor Aft2p; multicopy suppressor of temperature sensitive hsf1 mutant; induced by treatment with 8-methoxypsoralen and UVA irradiation	biological_process	molecular_function	cellular_component
YMR316C-A_p	YMR316C-A	YMR316C-A	hom	Uncharacterized	0.34980454949766	0.363242692246815	no	1736	0.364062454603615	1238	NA					Protein of unknown function; mRNA identified as translated by ribosome profiling data; overlaps the verified gene DIA1/YMR316W	biological_process	molecular_function	cellular_component
YBR271W	YBR271W	EFM2	hom	Verified	0.34905557918868	0.363523792141481	no	1737	0.399029868425662	1311	NA					S-adenosylmethionine-dependent methyltransferase; methylates translation elongation factors EF2 (Eft1p and Eft2p) and EF3A (Yef3p); belongs to the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; predicted to be involved in ribosome biogenesis	peptidyl-lysine methylation	S-adenosylmethionine-dependent methyltransferase activity|protein-lysine N-methyltransferase activity	cytoplasm
YOR121C_d	YOR121C	YOR121C	hom	Dubious	0.347675921222678	0.364041790951948	no	1738	0.363826816776474	1166	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GCY1/YOR120W	Unknown	Unknown	Unknown
YDL068W_d	YDL068W	YDL068W	hom	Dubious	0.347583031326102	0.364076675822409	no	1739	0.378717051836988	1275	NA					Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKL102C_d	YKL102C	YKL102C	hom	Dubious	0.347445168238137	0.364128452484959	no	1740	0.353596085533665	1171	NA					Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site	Unknown	Unknown	Unknown
YAL022C	YAL022C	FUN26	hom	Verified	0.346262152964648	0.36457285444099	no	1741	0.366721658629705	1204	NA					Vacuolar membrane transporter with broad nucleoside selectivity; may regulate balance of nicotinamide riboside (NmR) levels between cytosol and vacuole, contributing to salvage of NmR for use in cytosolic NAD+ synthesis	nucleoside transport|nicotinamide riboside transport|transmembrane transport	nicotinamide riboside transporter activity|nucleoside transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|intracellular|membrane
YNL180C	YNL180C	RHO5	hom	Verified	0.346089868970379	0.364637588455833	no	1742	0.360044493488179	1162	NA	FT	SIGNALING	NUCLEUS|PLASMA MEMBRANE		Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity	Rho protein signal transduction	GTPase activity	endomembrane system|fungal-type vacuole membrane|plasma membrane|nucleus|cytoplasm
YLR441C	YLR441C	RPS1A	hom	Verified	0.345682078032231	0.36479082726426	no	1743	0.38187717271797	1275	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Ribosomal protein 10 (rp10) of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1A has a paralog, RPS1B, that arose from the whole genome duplication	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit|90S preribosome
YMR305C	YMR305C	SCW10	hom	Verified	0.345508165300118	0.36485618639203	no	1744	0.369915891512235	1222	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	ENDOPLASMIC RETICULUM		Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p	conjugation with cellular fusion	glucosidase activity	fungal-type cell wall|extracellular region|endoplasmic reticulum|cytoplasm
YHR064C	YHR064C	SSZ1	hom	Verified	0.343051519487472	0.365779851111366	no	1745	0.317725705294477	1100	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION			Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP	cytoplasmic translation|regulation of translational fidelity|rRNA processing	unfolded protein binding	polysome|cytoplasm
YDR295C	YDR295C	HDA2	hom	Verified	0.342182685893545	0.366106707146682	no	1746	0.347077110586521	1159	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex containing an Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance	negative regulation of transcription from RNA polymerase II promoter|gene silencing by RNA|histone deacetylation|gene silencing involved in chronological cell aging	histone deacetylase activity|chromatin binding|DNA binding	nucleus|HDA1 complex
YMR191W	YMR191W	SPG5	hom	Verified	0.341674104856454	0.366298080932849	no	1747	0.373732425046817	1207	NA					Protein required for proteasome assembly during quiescence; binds to base of the proteasome regulartory particle; required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources	biological_process	molecular_function	cellular_component
YDL222C	YDL222C	FMP45	hom	Verified	0.340740597068857	0.366649436777328	no	1748	0.349282682920243	1167	NA	FT	CELL WALL ORG/BIOGENESIS	MITOCHONDRION|PLASMA MEMBRANE		Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C	fungal-type cell wall organization|ascospore formation	molecular_function	cell cortex|mitochondrion|integral to membrane|plasma membrane
YFR041C	YFR041C	ERJ5	hom	Verified	0.339590441947716	0.367082488523889	no	1749	0.350650320384324	1150	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Type I membrane protein with a J domain is required to preserve the folding capacity of the endoplasmic reticulum; loss of the non-essential ERJ5 gene leads to a constitutively induced unfolded protein response	protein folding	molecular_function	endoplasmic reticulum
YDR333C	YDR333C	RQC1	hom	Verified	0.339422014709601	0.36714591827815	no	1750	0.35449500393527	1152	NA					Component of the ribosome quality control complex (RQC); RQC (Rqc1p-Ltn1p-Tae2p-Cdc48p-Npl4p-Ufd1p), is a ribosome-bound complex required for the degradation of polypeptides arising from stalled translation; required along with Ltn1p for recruitment of the Cdc48p-Npl4p-Ufd1p AAA ATPase complex to the RQC	biological_process	molecular_function	cytoplasm
YNL213C	YNL213C	RRG9	hom	Verified	0.338914286930783	0.367337150665372	no	1751	0.372289010915737	1241	NA	FT	MITOCHONDRION ORGANIZATION	MITOCHONDRION		Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	mitochondrion organization|mitochondrial genome maintenance	molecular_function	mitochondrion
YNL091W	YNL091W	NST1	hom	Verified	0.338498187536461	0.367493896352252	no	1752	0.365205429404743	1207	NA					Protein of unknown function, mediates sensitivity to salt stress; interacts physically with the splicing factor Msl1p and also displays genetic interaction with MSL1	response to salt stress	molecular_function	cytoplasm
YLR149C	YLR149C	YLR149C	hom	Verified	0.338340258203617	0.367553394510197	no	1753	0.387309004539169	1276	NA					Protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	cellular_component
YHR175W-A_p	YHR175W-A	YHR175W-A	hom	Uncharacterized	0.337827602944021	0.367746553705634	no	1754	0.355534933430499	1174	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YMR316W	YMR316W	DIA1	hom	Verified	0.337679903875499	0.367802210243349	no	1755	0.383414378348678	1264	NA					Protein of unknown function, involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	pseudohyphal growth|invasive growth in response to glucose limitation	molecular_function	cytoplasm
YBR093C	YBR093C	PHO5	hom	Verified	0.337252097390723	0.367963433608425	no	1756	0.363046648657289	1209	NA	FT	RESPONSE TO NUTRIENT LEVELS			Repressible acid phosphatase (1 of 3) that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2	cellular response to phosphate starvation|phosphate-containing compound metabolic process|regulation of cell size	nucleoside-triphosphate diphosphatase activity|nucleoside-triphosphatase activity|acid phosphatase activity	fungal-type cell wall|cell wall-bounded periplasmic space
YIR033W	YIR033W	MGA2	hom	Verified	0.336126135945293	0.368387875116944	no	1757	0.299909070119533	1014	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|GENE SILENCING	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia|cellular response to cold|positive regulation of unsaturated fatty acid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|mRNA stabilization|positive regulation of transcription from RNA polymerase II promoter in response to cobalt ion|positive regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette	molecular_function	integral to endoplasmic reticulum membrane|nucleus
YHR103W	YHR103W	SBE22	hom	Verified	0.334552404151694	0.368981376876454	no	1758	0.371571828941092	1224	NA	FT	PROTEIN LOCALIZATION|CELL WALL ORG/BIOGENESIS	GOLGI APPARATUS		Protein involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; involved in bud growth	fungal-type cell wall organization	molecular_function	cytoplasm
YHR093W_d	YHR093W	AHT1	hom	Dubious	0.334366717007237	0.369051425743922	no	1759	0.362735748902727	1197	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; multicopy suppressor of glucose transport defects, likely due to the presence of an HXT4 regulatory element in the region	Unknown	Unknown	Unknown
YML116W	YML116W	ATR1	hom	Verified	0.334186184962555	0.369119534064511	no	1760	0.335961158716231	1115	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	PLASMA MEMBRANE		Multidrug efflux pump of the major facilitator superfamily; required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; ATR1 has a paralog, YMR279C, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	borate transport|drug transmembrane transport	drug transmembrane transporter activity|borate transmembrane transporter activity	integral to membrane|plasma membrane|vacuole
YHR106W	YHR106W	TRR2	hom	Verified	0.333973376401045	0.369199824443827	no	1761	0.323288814471187	1067	NA	FT	OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		Mitochondrial thioredoxin reductase; involved in protection against oxidative stress, required with Glr1p to maintain the redox state of Trx3p; contains active-site motif (CAVC) present in prokaryotic orthologs; binds NADPH and FAD; TRR2 has a paralog, TRR1, that arose from the whole genome duplication	cellular response to oxidative stress|cell redox homeostasis	thioredoxin-disulfide reductase activity	mitochondrion
YJR135C	YJR135C	MCM22	hom	Verified	0.333617380562633	0.369334150597559	no	1762	0.364634936971164	1203	NA	FT	CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME	KINETOCHORE	Outer kinetochore protein and component of the Ctf3 subcomplex; binds to centromeric DNA in a Ctf19p-dependent manner; involved in chromosome segregation and minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-K and fission yeast sim4	chromosome segregation|establishment of mitotic sister chromatid cohesion	molecular_function	condensed nuclear chromosome kinetochore
YOR299W	YOR299W	BUD7	hom	Verified	0.331682572501825	0.370064480776494	no	1763	0.368150241106712	1194	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM	GOLGI APPARATUS		Member of the ChAPs family (Chs5p-Arf1p-binding proteins); members include Bch1p, Bch2p, Bud7p, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; BUD7 has a paralog, BCH1, that arose from the whole genome duplication	Golgi to plasma membrane transport|fungal-type cell wall chitin biosynthetic process|cellular bud site selection	molecular_function	trans-Golgi network transport vesicle|clathrin-coated vesicle|exomer complex
YOR297C	YOR297C	TIM18	hom	Verified	0.331459105903012	0.37014886275138	no	1764	0.353466949883858	1170	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex	cellular response to oxidative stress|protein import into mitochondrial inner membrane|apoptotic process|response to acid|response to osmotic stress|response to arsenic-containing substance	protein channel activity	mitochondrion|integral to membrane|mitochondrial inner membrane protein insertion complex
YML054C	YML054C	CYB2	hom	Verified	0.330891496855795	0.370363222527305	no	1765	0.323427474674406	1087	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions	lactate metabolic process	L-lactate dehydrogenase (cytochrome) activity	mitochondrion|mitochondrial intermembrane space
YDL012C	YDL012C	YDL012C	hom	Verified	0.330421140885243	0.370540884808266	no	1766	0.343209221116084	1145	NA	FT		PLASMA MEMBRANE		Tail-anchored plasma membrane protein with a conserved CYSTM module; possibly involved in response to stress; may contribute to non-homologous end-joining (NHEJ) based on ydl012c htz1 double null phenotype; YDL012C has a paralog, YBR016W, that arose from the whole genome duplication	biological_process	molecular_function	plasma membrane
YGR219W_d	YGR219W	YGR219W	hom	Dubious	0.329839624264194	0.370760572723936	no	1767	0.385485190613697	1261	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRPL9/YGR220C	Unknown	Unknown	Unknown
YDR281C	YDR281C	PHM6	hom	Verified	0.3292003476047	0.371002130107673	no	1768	0.38219529082221	1292	NA					Protein of unknown function, expression is regulated by phosphate levels	biological_process	molecular_function	fungal-type vacuole
YLR125W_p	YLR125W	YLR125W	hom	Uncharacterized	0.328992821524139	0.371080556946867	no	1769	0.362879580328722	1204	NA					Putative protein of unknown function; mutant has decreased Ty3 transposition; YLR125W is not an essential gene	biological_process	molecular_function	cellular_component
YDR497C	YDR497C	ITR1	hom	Verified	0.326737582384514	0.371933186168464	no	1770	0.362399175489548	1193	NA	FT		PLASMA MEMBRANE		Myo-inositol transporter; has strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p; relative distribution to the vacuole increases upon DNA replication stress	myo-inositol transport|transmembrane transport	myo-inositol transmembrane transporter activity	integral to membrane|plasma membrane|membrane
YER083C	YER083C	GET2	hom	Verified	0.326115423918479	0.372168513901264	no	1771	0.416776977497232	1373	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for meiotic nuclear division	retrograde vesicle-mediated transport, Golgi to ER|protein insertion into ER membrane	protein anchor	integral to membrane|endoplasmic reticulum|GET complex
YFR021W	YFR021W	ATG18	hom	Verified	0.32574582521409	0.372308335023874	no	1772	0.376463693581285	1272	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION|VACUOLAR PROTEIN PROCESSING			Phosphoinositide binding protein; required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein; relocalizes from vacuole to cytoplasm upon DNA replication stress; has 4 mammalian homologs WIPI1, WIPI2, WIPI3 and WIPI4/WDR45; mutations in human WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood	piecemeal microautophagy of nucleus|peroxisome degradation|vacuolar protein processing|macroautophagy|late endosome to vacuole transport|CVT pathway	ubiquitin binding|phosphatidylinositol binding	cytosol|endosome|fungal-type vacuole membrane|PAS complex|pre-autophagosomal structure
YBR020W	YBR020W	GAL1	hom	Verified	0.325624140279351	0.372354372755565	no	1773	0.360562997380414	1196	NA	FT	CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS			Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; GAL1 has a paralog, GAL3, that arose from the whole genome duplication	galactose catabolic process via UDP-galactose|carbohydrate phosphorylation|positive regulation of transcription by galactose	galactokinase activity	cytoplasm
YDR475C	YDR475C	JIP4	hom	Verified	0.324980556119193	0.372597893820071	no	1774	0.365788939290962	1207	NA					Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence	biological_process	molecular_function	cellular_component
YDR423C	YDR423C	CAD1	hom	Verified	0.324234782504028	0.372880145305491	no	1775	0.384409229072291	1276	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		AP-1-like basic leucine zipper (bZIP) transcriptional activator; involved in stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins; binds consensus sequence TTACTAA; CAD1 has a paralog, YAP1, that arose from the whole genome duplication	cellular response to cadmium ion|positive regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus|cytoplasm
YJR040W	YJR040W	GEF1	hom	Verified	0.323889269253189	0.373010934177518	no	1776	0.370834004464246	1257	NA	FF|FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOPLASMIC RETICULUM|GOLGI APPARATUS|PLASMA MEMBRANE		Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism	cellular copper ion homeostasis|cellular iron ion homeostasis	voltage-gated chloride channel activity	endosome|integral to membrane|endoplasmic reticulum|Golgi apparatus|plasma membrane|fungal-type vacuole|Golgi medial cisterna
YNL274C	YNL274C	GOR1	hom	Verified	0.323872224547421	0.373017386574849	no	1777	0.362163206704855	1194	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS	NUCLEUS|MITOCHONDRION		Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress	glyoxylate catabolic process|metabolic process	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|glyoxylate reductase activity	mitochondrion|nucleus|cytoplasm
YLL009C	YLL009C	COX17	hom	Verified	0.323634170238041	0.37310750748696	no	1778	0.366570950284068	1200	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs	mitochondrial respiratory chain complex IV assembly|intracellular copper ion transport	copper chaperone activity	cytosol|mitochondrion|mitochondrial intermembrane space
YFL003C	YFL003C	MSH4	hom	Verified	0.32277367612306	0.373433325123505	no	1779	0.359011516195738	1190	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS|CHROMOSOME		Protein involved in meiotic recombination, required for normal levels of crossing over, colocalizes with Zip2p to discrete foci on meiotic chromosomes, has homology to bacterial MutS protein	reciprocal meiotic recombination	DNA binding	nuclear chromosome
YIL085C	YIL085C	KTR7	hom	Verified	0.322202745391125	0.373649552392063	no	1780	0.363317269993455	1201	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	GOLGI APPARATUS		Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR7 has a paralog, KTR5, that arose from the whole genome duplication	fungal-type cell wall organization|protein N-linked glycosylation	mannosyltransferase activity	Golgi apparatus
YOL014W_p	YOL014W	YOL014W	hom	Uncharacterized	0.322171663784583	0.373661324998968	no	1781	0.399059305492893	1319	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YGR250C	YGR250C	YGR250C	hom	Verified	0.322061485747206	0.373703057469744	no	1782	0.376138727702167	1239	NA					Putative RNA binding protein; localizes to stress granules induced by glucose deprivation; interacts with Rbg1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress	biological_process	RNA binding	cytoplasmic stress granule|cytoplasm
YOL145C	YOL145C	CTR9	hom	Verified	0.321946890348751	0.373746464688937	no	1783	0.428873661025988	1410	NA	FT	TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|GENE SILENCING	NUCLEUS|CHROMOSOME	RNA POL II, HOLOENZYME	Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cyclin genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; contains TPR repeats	transcription elongation from RNA polymerase I promoter|mRNA 3'-end processing|regulation of chromatin silencing at telomere|snoRNA transcription from an RNA polymerase II promoter|regulation of transcription by chromatin organization|transcription from RNA polymerase I promoter|regulation of histone H3-K4 methylation|regulation of transcription-coupled nucleotide-excision repair|regulation of transcription initiation from RNA polymerase II promoter|snoRNA 3'-end processing|Unknown|regulation of transcription involved in G1 phase of mitotic cell cycle|transcription elongation from RNA polymerase II promoter	RNA polymerase II core binding|triplex DNA binding|RNA polymerase II transcription factor binding transcription factor activity	transcriptionally active chromatin|nucleus|Cdc73/Paf1 complex
YGR032W	YGR032W	GSC2	hom	Verified	0.321585840141903	0.373883236194501	no	1784	0.363403449281293	1245	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM	PLASMA MEMBRANE|CYTOSKELETON		Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)	ascospore wall assembly|(1->3)-beta-D-glucan biosynthetic process	1,3-beta-D-glucan synthase activity	1,3-beta-D-glucan synthase complex|integral to membrane|actin cap|prospore membrane
YDR067C_p	YDR067C	OCA6	hom	Uncharacterized	0.321069199730602	0.374078975338024	no	1785	0.38798043387384	1275	NA					Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying positive-strand RNA virus replication; null mutation confers sensitivity to tunicamycin and DTT	biological_process	molecular_function	cytoplasm
YML068W	YML068W	ITT1	hom	Verified	0.320280533462794	0.374377839304619	no	1786	0.358121402348602	1225	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION			Protein that modulates the efficiency of translation termination, interacts with translation release factors eRF1 (Sup45p) and eRF3 (Sup35p) in vitro, contains a zinc finger domain characteristic of the TRIAD class of proteins	regulation of translational termination	molecular_function	cellular_component
YOL041C	YOL041C	NOP12	hom	Verified	0.319798737661189	0.374560452302906	no	1787	0.363061096400329	1186	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Nucleolar protein involved in pre-25S rRNA processing and biogenesis of large 60S ribosomal subunit; contains an RNA recognition motif (RRM); binds to Ebp2; similar to Nop13p and Nsr1p	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	RNA binding	nucleolus|preribosome
YLL006W-A_p	YLL006W-A	YLL006W-A	hom	Uncharacterized	0.319405962375218	0.374709345058676	no	1788	0.362514456893208	1171	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YLR025W	YLR025W	SNF7	hom	Verified	0.317930968378938	0.375268650532325	no	1789	0.414275050999707	1371	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT			One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes	cellular response to anoxia|intralumenal vesicle formation|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|late endosome to vacuole transport	protein binding	ESCRT III complex|cytoplasm
YMR294W	YMR294W	JNM1	hom	Verified	0.317912825772265	0.375275531693632	no	1790	0.399911910287829	1341	NA	FF|FT	CELL CYCLE|CYTOSKELETON ORGANIZATION	CYTOSKELETON		Component of the yeast dynactin complex, consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B	nuclear migration|establishment of mitotic spindle orientation	structural constituent of cytoskeleton	dynactin complex|cell cortex|spindle pole body|astral microtubule
YER123W	YER123W	YCK3	hom	Verified	0.317469396087693	0.375443728856705	no	1791	0.407491845696931	1361	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN PHOSPHORYLATION	ENDOMEMBRANE SYSTEM|NUCLEUS|PLASMA MEMBRANE		Palmitoylated, vacuolar membrane-localized casein kinase I isoform; negatively regulates vacuole fusion during hypertonic stress via phosphorylation of Vps41p; shares essential functions with Hrr25p; regulates vesicle fusion in AP-3 pathway	vesicle-mediated transport|protein phosphorylation	protein serine/threonine kinase activity|protein kinase activity	fungal-type vacuole membrane|plasma membrane|nucleus|fungal-type vacuole
YJR135W-A	YJR135W-A	TIM8	hom	Verified	0.31736450339145	0.375483519134003	no	1792	0.360176453957243	1184	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial intermembrane space protein, forms a complex with Tim13p that delivers a subset of hydrophobic proteins to the TIM22 complex for inner membrane insertion; homolog of human TIMM8A, implicated in Mohr-Tranebjaerg syndrome	protein import into mitochondrial inner membrane	protein transporter activity	mitochondrion|integral to membrane|mitochondrial intermembrane space protein transporter complex
YGL231C	YGL231C	EMC4	hom	Verified	0.317304980522602	0.375506099288176	no	1793	0.390989356679342	1283	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm ZK616.6/EMC-4, fly CG11137, human TMM85	protein folding in endoplasmic reticulum	molecular_function	ER membrane protein complex|endoplasmic reticulum
YHR126C_p	YHR126C	ANS1	hom	Uncharacterized	0.317160474212799	0.375560919904714	no	1794	0.376780165693359	1230	NA	FT		PLASMA MEMBRANE		Putative GPI protein; transcription dependent upon Azf1p	biological_process	molecular_function	cellular_component
YMR272C	YMR272C	SCS7	hom	Verified	0.317018248196548	0.375614877911425	no	1795	0.393206840376196	1296	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Sphingolipid alpha-hydroxylase, functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth	inositolphosphoceramide metabolic process	fatty acid alpha-hydroxylase activity	integral to membrane|endoplasmic reticulum|membrane
YGR207C	YGR207C	CIR1	hom	Verified	0.316945699610111	0.375642402484605	no	1796	0.348689972594246	1166	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Mitochondrial protein that interacts with frataxin (Yfh1p); putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-beta; may have a role in oxidative stress response	biological_process	molecular_function	mitochondrion
YGL050W	YGL050W	TYW3	hom	Verified	0.314289019618014	0.376650768549289	no	1797	0.377283874993211	1233	NA	FT	RNA PROCESSING			tRNA methyltransferase required for synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions	tRNA methylation|wybutosine biosynthetic process	tRNA methyltransferase activity	cellular_component
YDL110C	YDL110C	TMA17	hom	Verified	0.313155501905616	0.377081261817323	no	1798	0.374766313739871	1229	NA	FT		NUCLEUS		Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion	biological_process	molecular_function	ribosome|nucleus|cytoplasm
YIL054W_p	YIL054W	YIL054W	hom	Uncharacterized	0.312790376835449	0.377219963489633	no	1799	0.381030864757346	1288	NA					Protein of unknown function; expressed at both mRNA and protein levels	biological_process	molecular_function	cellular_component
YKL109W	YKL109W	HAP4	hom	Verified	0.311985038285189	0.377525946981034	no	1800	0.374727011284923	1242	NA	FT	TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex	regulation of cellular respiration|carbon catabolite activation of transcription from RNA polymerase II promoter	RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor binding transcription factor activity	CCAAT-binding factor complex
YNL083W	YNL083W	SAL1	hom	Verified	0.311257762338037	0.377802337136291	no	1801	0.367395478015464	1238	NA	FT		MITOCHONDRION		ADP/ATP transporter; member of the Ca2+-binding subfamily of mitochondrial carriers, with two EF-hand motifs; transport activity of either Sal1p or Pet9p is critical for viability; polymorphic in different S. cerevisiae strains	ATP transport|ADP transport|mitochondrial transport	ATP:ADP antiporter activity|calcium ion binding	mitochondrion|integral to membrane|mitochondrial inner membrane
YKR090W	YKR090W	PXL1	hom	Verified	0.310033958721389	0.378267566245101	no	1802	0.382041898715898	1280	NA	FT	SIGNALING	SITE OF POLARIZED GROWTH		Protein that localizes to sites of polarized growth; required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; contains LIM domains and has similarity to metazoan paxillin; relocalizes from bud neck to cytoplasm upon DNA replication stress	maintenance of cell polarity|regulation of Rho protein signal transduction	Rho GDP-dissociation inhibitor activity	incipient cellular bud site|cellular bud|mating projection tip|cellular bud neck|cytoplasm|cellular bud tip
YAL009W	YAL009W	SPO7	hom	Verified	0.309071974840889	0.378633388512259	no	1803	0.397810341197998	1312	NA	FF|FT	CELL CYCLE|LIPID METABOLISM|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM		Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology, premeiotic replication, and sporulation	negative regulation of phospholipid biosynthetic process|nuclear envelope organization	phosphoprotein phosphatase activity	Nem1-Spo7 phosphatase complex|integral to membrane
YMR081C	YMR081C	ISF1	hom	Verified	0.308703691479481	0.378773467752	no	1804	0.371045267906109	1227	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY			Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant	aerobic respiration	molecular_function	cellular_component
YDR042C_p	YDR042C	YDR042C	hom	Uncharacterized	0.308340270234122	0.378911713263381	no	1805	0.368021197987763	1214	NA					Putative protein of unknown function; expression is increased in ssu72-ts69 mutant	biological_process	molecular_function	cellular_component
YOR320C	YOR320C	GNT1	hom	Verified	0.307868372580448	0.379091246337628	no	1806	0.38076965044389	1246	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		N-acetylglucosaminyltransferase capable of modification of N-linked glycans in the Golgi apparatus	protein N-linked glycosylation	acetylglucosaminyltransferase activity	Golgi medial cisterna
YHR140W_p	YHR140W	YHR140W	hom	Uncharacterized	0.307716224266473	0.379149136601219	no	1807	0.364236651172621	1208	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative integral membrane protein of unknown function	biological_process	molecular_function	integral to membrane
YJL110C	YJL110C	GZF3	hom	Verified	0.307440579663782	0.379254022343802	no	1808	0.371864756036303	1230	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS	NUCLEUS		GATA zinc finger protein; negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p; GZF3 has a paralog, DAL80, that arose from the whole genome duplication	maintenance of protein location in nucleus|nitrogen catabolite repression of transcription|negative regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding RNA polymerase II transcription factor activity|sequence-specific DNA binding	nucleus
YPL005W	YPL005W	AEP3	hom	Verified	0.306523555052191	0.379603024029184	no	1809	0.359726798146678	1197	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Protein that may facilitate use of unformylated tRNA-Met in mitochondrial translation initiation; localized to the matrix face of the mitochondrial inner membrane; stabilizes the bicistronic AAP1-ATP6 mRNA	mRNA metabolic process|mitochondrial translational initiation	molecular_function	mitochondrion|mitochondrial inner membrane|cytoplasm|extrinsic to membrane
YKR055W	YKR055W	RHO4	hom	Verified	0.30389406980773	0.380604297938359	no	1810	0.375179035801653	1276	NA	FT	SIGNALING|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely to be involved in the establishment of cell polarity	positive regulation of formin-nucleated actin cable assembly|maintenance of cell polarity|regulation of formin-nucleated actin cable assembly	GTPase activity	incipient cellular bud site|plasma membrane|cellular bud neck
YMR017W	YMR017W	SPO20	hom	Verified	0.30376037189417	0.380655229808225	no	1811	0.358228682208458	1216	NA	FT		PLASMA MEMBRANE		Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog	ascospore-type prospore assembly	SNAP receptor activity	SNARE complex|prospore membrane
YGL168W	YGL168W	HUR1	hom	Verified	0.303409404267056	0.380788939846084	no	1812	0.445685817172826	1473	NA	FF|FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS			Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene	DNA replication	molecular_function	cellular_component
YKL197C	YKL197C	PEX1	hom	Verified	0.302614544635874	0.38109181444324	no	1813	0.378819404759491	1260	NA	FT	PROTEIN LOCALIZATION|SIGNALING|PEROXISOME ORGANIZATION			AAA-peroxin that heterodimerizes with AAA-peroxin Pex6p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; induced by oleic acid and upregulated during anaerobiosis	protein import into peroxisome matrix, receptor recycling	ATPase activity|protein heterodimerization activity	peroxisomal membrane|peroxisome
YBR241C_p	YBR241C	YBR241C	hom	Uncharacterized	0.302431017256129	0.381161756372364	no	1814	0.346944227551058	1139	NA					Putative transporter, member of the sugar porter family; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane; YBR241C is not an essential gene	transport|transmembrane transport	substrate-specific transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|membrane
YDL176W	YDL176W	YDL176W	hom	Verified	0.302091092367701	0.381291311341946	no	1815	0.365100994286864	1211	NA					Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene	biological_process	molecular_function	cellular_component
YJL151C	YJL151C	SNA3	hom	Verified	0.301149806718654	0.381650131258701	no	1816	0.380213125949308	1250	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM		Protein involved in efficient MVB sorting of proteins to the vacuole; may function as an RSP5 adapter protein for MVB cargos; integral membrane protein localized to vacuolar intralumenal vesicles	cellular protein catabolic process|endosome transport via multivesicular body sorting pathway	ubiquitin protein ligase binding	fungal-type vacuole lumen|integral to membrane
YLR426W_p	YLR426W	TDA5	hom	Uncharacterized	0.30035498398623	0.381953198455613	no	1817	0.422375316960619	1367	NA	FT	OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele	response to drug	molecular_function	mitochondrion|integral to membrane
YOL011W	YOL011W	PLB3	hom	Verified	0.300218101494173	0.38200539928053	no	1818	0.36056354292973	1187	NA	FT	LIPID METABOLISM	PLASMA MEMBRANE		Phospholipase B (lysophospholipase) involved in phospholipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro	phosphatidylinositol metabolic process|phosphatidylserine catabolic process	lysophospholipase activity	extracellular region|plasma membrane
YFR006W_p	YFR006W	YFR006W	hom	Uncharacterized	0.299697468874664	0.382203964730429	no	1819	0.378623040719497	1302	NA					Putative X-Pro aminopeptidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YFR006W is not an essential gene	biological_process	molecular_function	cytoplasm
YMR205C	YMR205C	PFK2	hom	Verified	0.299605031255909	0.38223922299846	no	1820	0.493680378284755	1717	NA	FT	CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes	proton transport|glycolysis	mRNA binding|6-phosphofructokinase activity	mitochondrion|6-phosphofructokinase complex|cytoplasm
YGR165W	YGR165W	MRPS35	hom	Verified	0.298871339951269	0.382519107794217	no	1821	0.40492547661454	1325	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial small ribosomal subunit
YDR258C	YDR258C	HSP78	hom	Verified	0.297928023488154	0.382879049491441	no	1822	0.377753832716812	1279	NA	FT	PROTEIN LOCALIZATION|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; able to prevent the aggregation of misfolded proteins as well as resolubilize protein aggregates	positive regulation of mitochondrial translation in response to stress|protein refolding|protein stabilization|protein import into mitochondrial matrix|mitochondrial genome maintenance|protein unfolding|cellular response to heat	misfolded protein binding|ATPase activity	mitochondrion|mitochondrial matrix
YGL186C	YGL186C	TPN1	hom	Verified	0.297157094148086	0.383173288496457	no	1823	0.451402410866884	1486	NA	FF|FT		PLASMA MEMBRANE		Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p	vitamin transport	vitamin transporter activity	integral to membrane|plasma membrane
YOR109W	YOR109W	INP53	hom	Verified	0.296780182598079	0.383317168093743	no	1824	0.377757767908484	1237	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION	CYTOSKELETON		Polyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains	phosphatidylinositol dephosphorylation	phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|phosphatidylinositol-3-phosphatase activity|phosphatidylinositol-4-phosphate phosphatase activity	membrane|actin cortical patch|cytoplasm
YDR193W_d	YDR193W	YDR193W	hom	Dubious	0.295434298414321	0.383831067794009	no	1825	0.362070184916297	1242	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGR137W_d	YGR137W	YGR137W	hom	Dubious	0.29516626304	0.38393343631997	no	1826	0.381985037073655	1261	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGR127W_p	YGR127W	YGR127W	hom	Uncharacterized	0.294788756073571	0.384077628157556	no	1827	0.3752418676829	1258	NA					Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response	biological_process	molecular_function	cellular_component
YMR201C	YMR201C	RAD14	hom	Verified	0.293455058759262	0.384587172994576	no	1828	0.389359345488525	1289	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein	nucleotide-excision repair, DNA damage recognition	damaged DNA binding|zinc ion binding	nucleotide-excision repair factor 1 complex|nucleus
YDR350C	YDR350C	ATP22	hom	Verified	0.292281095950001	0.385035855660365	no	1829	0.393957341796681	1319	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Specific translational activator for the mitochondrial ATP6 mRNA, encoding a subunit of F1F0 ATP synthase; localized to the mitochondrial inner membrane	proton-transporting ATP synthase complex biogenesis|positive regulation of mitochondrial translation	translation regulator activity	mitochondrial inner membrane
YNR008W	YNR008W	LRO1	hom	Verified	0.29210430857082	0.385103436259101	no	1830	0.391065085418511	1286	NA	FT	LIPID METABOLISM	ENDOPLASMIC RETICULUM		Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase	lipid storage|triglyceride biosynthetic process	phospholipid:diacylglycerol acyltransferase activity	lipid particle|perinuclear endoplasmic reticulum
YFR038W	YFR038W	IRC5	hom	Verified	0.291785378190325	0.385225362758975	no	1831	0.366122342189899	1219	NA	FT		NUCLEUS		Putative ATPase containing the DEAD/H helicase-related sequence motif; null mutant displays increased levels of spontaneous Rad52p foci	mitotic recombination	molecular_function	cellular_component
YCR028C	YCR028C	FEN2	hom	Verified	0.291205623057895	0.385447031136357	no	1832	0.394591863342759	1273	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	PLASMA MEMBRANE		Plasma membrane H+-pantothenate symporter; confers sensitivity to the antifungal agent fenpropimorph; relocalizes from vacuole to cytoplasm upon DNA replication stress	pantothenate transmembrane transport|endocytosis	pantothenate transmembrane transporter activity	integral to membrane|plasma membrane
YOL013W-A_p	YOL013W-A	YOL013W-A	hom	Uncharacterized	0.291159616823254	0.385464623144754	no	1833	0.388438622781157	1279	NA					Putative protein of unknown function; identified by SAGE	biological_process	molecular_function	integral to membrane
YML028W	YML028W	TSA1	hom	Verified	0.291077116596626	0.385496170430504	no	1834	0.383170824538966	1242	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|TRANSLATION|OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS			Thioredoxin peroxidase; acts as both a ribosome-associated and free cytoplasmic antioxidant; self-associates to form a high-molecular weight chaperone complex under oxidative stress; deletion results in mutator phenotype; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress	protein folding|cellular response to oxidative stress|replicative cell aging|DNA protection|DNA damage checkpoint|cell redox homeostasis|response to hydroperoxide	unfolded protein binding|ribosome binding|peroxiredoxin activity|thioredoxin peroxidase activity	cytosol|polysome|cytoplasm
YDR277C	YDR277C	MTH1	hom	Verified	0.29045586450462	0.385733755517625	no	1835	0.386102965878361	1272	NA	FT	SIGNALING			Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation	glucose transport|signal transduction	molecular_function	cellular_component
YBR025C	YBR025C	OLA1	hom	Verified	0.29034892863659	0.385774655268869	no	1836	0.389163532398073	1272	NA					P-loop ATPase with similarity to human OLA1 and bacterial YchF; identified as specifically interacting with the proteasome; protein abundance increases in response to hydrogen peroxide and to DNA replication stress	biological_process	ATPase activity	cytoplasm
YNL205C_d	YNL205C	YNL205C	hom	Dubious	0.287991374778295	0.386676670518166	no	1837	0.389790612324606	1254	NA					Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGL100W	YGL100W	SEH1	hom	Verified	0.287533565938839	0.38685190229821	no	1838	0.391049773527313	1314	NA	FF|FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|PLASMA MEMBRANE	NUCLEAR PORE	Component of two distinct complexes; subunit of the Nup84 nuclear pore sub-complex (NPC) and the Seh1-associated (SEA) complex; the the NUP84 subcomplex contributes to nucleocytoplasmic transport and NPC biogenesis; the SEA complex is a coatamer-related complex that associates dynamically with the vacuole; homologous to human SEH1	nucleocytoplasmic transport	structural constituent of nuclear pore	fungal-type vacuole membrane|integral to membrane|nuclear pore|Seh1-associated complex|nuclear pore outer ring
YBR267W	YBR267W	REI1	hom	Verified	0.286117586727942	0.387394031052399	no	1839	0.377442021656634	1276	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RIBOSOME BIOGENESIS|CELL DIVISION		RIBOSOME	Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network	ribosomal large subunit biogenesis|nucleocytoplasmic transport|mitotic cell cycle|budding cell bud growth	sequence-specific DNA binding	cytosolic large ribosomal subunit|preribosome, large subunit precursor|cytoplasm
YOL101C	YOL101C	IZH4	hom	Verified	0.285449947429492	0.387649722983146	no	1840	0.403901418946768	1348	NA	FT	LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family; expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism; protein increases in abundance and relocalizes from nucleus to ER upon DNA replication stress	cellular zinc ion homeostasis|cellular lipid metabolic process	metal ion binding	integral to membrane|membrane
YNL120C_d	YNL120C	YNL120C	hom	Dubious	0.284321785478757	0.388081896183532	no	1841	0.381643424889382	1267	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; deletion enhances replication of Brome mosaic virus in S. cerevisiae, but likely due to effects on the overlapping gene	Unknown	Unknown	Unknown
YDR099W	YDR099W	BMH2	hom	Verified	0.283288564928671	0.388477821139407	no	1842	0.397021590711701	1301	NA	FT	CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress	glycogen metabolic process|ascospore formation|Ras protein signal transduction|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|DNA damage checkpoint|DNA replication initiation|signal transduction involved in filamentous growth|pseudohyphal growth|fungal-type cell wall chitin biosynthetic process|pre-replicative complex assembly	DNA replication origin binding|phosphoserine binding	nucleus|plasma membrane
YBL100W-C_p	YBL100W-C	YBL100W-C	hom	Uncharacterized	0.282515275289795	0.388774217723474	no	1843	0.388171804920129	1309	NA					Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching	biological_process	molecular_function	cellular_component
YHL008C_p	YHL008C	YHL008C	hom	Uncharacterized	0.282157182308936	0.388911494240566	no	1844	0.377408686645196	1241	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Putative protein of unknown function, may be involved in the uptake of chloride ions; does not appear to be involved in monocarboxylic acid transport; green fluorescent protein (GFP)-fusion protein localizes to the vacuole	chloride transport|monocarboxylic acid transport	monocarboxylic acid transmembrane transporter activity|transporter activity	integral to membrane|fungal-type vacuole
YHR021W-A_p	YHR021W-A	ECM12	hom	Uncharacterized	0.281652762512177	0.389104889312552	no	1845	0.385674858807053	1290	NA	FT	CELL WALL ORG/BIOGENESIS			Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity	fungal-type cell wall organization	molecular_function	cellular_component
YDR297W	YDR297W	SUR2	hom	Verified	0.281481933464751	0.389170391576998	no	1846	0.399859606500924	1313	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis	sphingolipid metabolic process	sphingosine hydroxylase activity	integral to membrane|endoplasmic reticulum membrane
YOR029W_d	YOR029W	YOR029W	hom	Dubious	0.280573989779617	0.38951858405809	no	1847	0.35128646220326	1167	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR461W	YDR461W	MFA1	hom	Verified	0.28044117997088	0.389569523489566	no	1848	0.394635164083364	1306	NA	FT	SIGNALING	PLASMA MEMBRANE		Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA2	pheromone-dependent signal transduction involved in conjugation with cellular fusion	mating pheromone activity	extracellular region
YDL177C_p	YDL177C	YDL177C	hom	Uncharacterized	0.280403586235616	0.389583942976217	no	1849	0.374977101270757	1252	NA					Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene	biological_process	molecular_function	cellular_component
YHR176W	YHR176W	FMO1	hom	Verified	0.28000646243985	0.389736273413856	no	1850	0.392688061226741	1273	NA	FT	OXIDATION-REDUCTION PROCESS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins	protein folding	N,N-dimethylaniline monooxygenase activity	endoplasmic reticulum membrane
YIL042C	YIL042C	PKP1	hom	Verified	0.279969973977067	0.389750270663945	no	1851	0.383187320501663	1257	NA	FT	SIGNALING|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION	MITOCHONDRION		Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p	peptidyl-serine phosphorylation|protein phosphorylation|carbon utilization	protein kinase activity|pyruvate dehydrogenase (acetyl-transferring) kinase activity	mitochondrion
YFR024C-A	YFR024C-A	LSB3	hom	Verified	0.279726951975553	0.389843499387221	no	1852	0.370752844520043	1231	NA	FT		MITOCHONDRION|SITE OF POLARIZED GROWTH		Protein containing a C-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein abundance increases in response to DNA replication stress; LSB3 has a paralog, YSC84, that arose from the whole genome duplication	actin cortical patch localization	molecular_function	mitochondrion|cellular bud neck|cytoplasm
YDR505C	YDR505C	PSP1	hom	Verified	0.279326593963469	0.389997099572852	no	1853	0.384942674609539	1267	NA	FT		MITOCHONDRION		Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrion|cytoplasm
YGR149W_p	YGR149W	YGR149W	hom	Uncharacterized	0.278088322555905	0.390472279793567	no	1854	0.379467473840473	1244	NA					Putative protein of unknown function; predicted to be an integal membrane protein	biological_process	molecular_function	integral to membrane
YPR087W_d	YPR087W	VPS69	hom	Dubious	0.276883936482303	0.390934613698776	no	1855	0.403982559473253	1337	NA					Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene SRP54; deletion causes a vacuolar protein sorting defect	Unknown	Unknown	Unknown
YMR130W_p	YMR130W	YMR130W	hom	Uncharacterized	0.275709316329508	0.391385669744153	no	1856	0.365075393483954	1204	NA					Putative protein of unknown function; YMR130W is not an essential gene	biological_process	molecular_function	cellular_component
YJL052W	YJL052W	TDH1	hom	Verified	0.274864306196736	0.391710245396405	no	1857	0.39881572841127	1310	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY	MITOCHONDRION		Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress	gluconeogenesis|glycolysis	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity	mitochondrion|fungal-type cell wall|lipid particle|plasma membrane|cytoplasm
YOL154W	YOL154W	ZPS1	hom	Verified	0.274515485383806	0.391844252465504	no	1858	0.376457959601782	1240	NA					Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH	biological_process	molecular_function	fungal-type cell wall|fungal-type vacuole
YDR129C	YDR129C	SAC6	hom	Verified	0.27201655273533	0.392804645917692	no	1859	0.454394271678942	1516	NA	FF|FT	VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton; relocalizes from plasma membrane to cytoplasm upon DNA replication stress	bipolar cellular bud site selection|actin filament organization|endocytosis|response to osmotic stress	actin filament binding|protein binding, bridging	actin filament bundle|mating projection tip|actin cortical patch
YNL242W	YNL242W	ATG2	hom	Verified	0.271679247888339	0.392934329556104	no	1860	0.387427240491742	1279	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION			Peripheral membrane protein required for autophagic vesicle formation; also required for vesicle formation during pexophagy and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria; forms cytoplasmic foci upon DNA replication stress	mitochondrion degradation|piecemeal microautophagy of nucleus|peroxisome degradation|CVT pathway|autophagic vacuole assembly	molecular_function	pre-autophagosomal structure|cytoplasm|extrinsic to membrane
YGR189C	YGR189C	CRH1	hom	Verified	0.271338618877548	0.393065303297011	no	1861	0.385186220283156	1294	NA	FT	CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM			Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress	fungal-type cell wall organization|cell wall chitin metabolic process	transferase activity, transferring glycosyl groups	incipient cellular bud site|fungal-type cell wall
YJL193W_p	YJL193W	YJL193W	hom	Uncharacterized	0.270451832801439	0.393406334201128	no	1862	0.395343029863391	1286	NA					Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect	biological_process	molecular_function	integral to membrane
YOL111C	YOL111C	MDY2	hom	Verified	0.270381650726596	0.393433327584989	no	1863	0.424304668783681	1406	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION	NUCLEUS		Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Get4p; required for efficient mating; involved in shmoo formation and nuclear migration in the pre-zygote; associates with ribosomes	protein insertion into ER membrane|cell morphogenesis involved in conjugation with cellular fusion|posttranslational protein targeting to membrane	molecular_function	ribosome|TRC complex|nucleus|cytoplasm
YMR242W-A_p	YMR242W-A	YMR242W-A	hom	Uncharacterized	0.269918417520413	0.393611508881268	no	1864	0.383987166493531	1265	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YDR018C_p	YDR018C	YDR018C	hom	Uncharacterized	0.269880598379955	0.393626056887134	no	1865	0.389983059662793	1312	NA	FT	LIPID METABOLISM			Probable membrane protein with three predicted transmembrane domains; similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase; YDR018C has a paralog, CST26, that arose from the whole genome duplication	phospholipid biosynthetic process	transferase activity, transferring acyl groups	integral to membrane
YNL013C_d	YNL013C	YNL013C	hom	Dubious	0.269754073697001	0.393674728607952	no	1866	0.378977956575461	1241	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF HEF3/YNL014W	Unknown	Unknown	Unknown
YNL129W	YNL129W	NRK1	hom	Verified	0.269725498710823	0.39368572111009	no	1867	0.383987172236109	1274	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM			Nicotinamide riboside kinase, catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis	nicotinamide riboside metabolic process|NAD biosynthesis via nicotinamide riboside salvage pathway|NAD biosynthetic process	nicotinic acid riboside kinase activity|ribosylnicotinamide kinase activity	cytoplasm
YGL180W	YGL180W	ATG1	hom	Verified	0.26949339024713	0.393775013977885	no	1868	0.393393457318822	1282	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Protein ser/thr kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for phagophore assembly site formation; during autophagy forms a complex with Atg13p and Atg17p	piecemeal microautophagy of nucleus|mitochondrion degradation|protein phosphorylation|CVT pathway|autophagic vacuole assembly	protein serine/threonine kinase activity|protein kinase activity	cytosol|pre-autophagosomal structure|Atg1p signaling complex
YAL053W	YAL053W	FLC2	hom	Verified	0.268959111616203	0.393980573893644	no	1869	0.406482014025331	1363	NA	FT	CELL WALL ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication	protein folding|fungal-type cell wall biogenesis|FAD transport|transmembrane transport	FAD transmembrane transporter activity	integral to membrane|endoplasmic reticulum|cytoplasm
YNR012W	YNR012W	URK1	hom	Verified	0.268208741064705	0.394269323510654	no	1870	0.408132876589188	1353	NA	FT	NUCLEOTIDE METABOLISM	NUCLEUS		Uridine/cytidine kinase, component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP; involved in the pyrimidine deoxyribonucleotide salvage pathway, converting deoxycytidine into dCMP	pyrimidine-containing compound salvage	uridine kinase activity	nucleus|cytoplasm
YFL031W	YFL031W	HAC1	hom	Verified	0.267389698258295	0.394584565189471	no	1871	0.376316928754565	1242	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|SIGNALING	NUCLEUS		Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog); regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway facilitates efficient Hac1p synthesis; protein abundance increases in response to DNA replication stress	endoplasmic reticulum unfolded protein response|positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response|negative regulation of transcription from RNA polymerase II promoter during meiosis|positive regulation of transcription from RNA polymerase II promoter	sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity	nucleus
YOL140W	YOL140W	ARG8	hom	Verified	0.266400518795733	0.394965382859116	no	1872	0.391484533572159	1267	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	MITOCHONDRION		Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine	arginine biosynthetic process|ornithine biosynthetic process	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity	mitochondrion|mitochondrial matrix
YDR079C-A	YDR079C-A	TFB5	hom	Verified	0.266165952077044	0.395055701886029	no	1873	0.394719600352972	1319	NA	FT	TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION	NUCLEUS	RNA POL II, HOLOENZYME	Component of the RNA polymerase II general transcription and DNA repair factor TFIIH; involved in transcription initiation and in nucleotide-excision repair; homolog of Chlamydomonas reinhardtii REX1-S protein involved in DNA repair	phosphorylation of RNA polymerase II C-terminal domain|nucleotide-excision repair|transcription from RNA polymerase II promoter	core RNA polymerase binding transcription factor activity	core TFIIH complex|holo TFIIH complex|nucleus
YJL053W	YJL053W	PEP8	hom	Verified	0.266143787102767	0.39506423671713	no	1874	0.409269515071303	1360	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM		Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress	protein retention in Golgi apparatus|retrograde transport, endosome to Golgi	protein transporter activity	endosome|retromer complex, inner shell|retromer complex
YHR086W-A_p	YHR086W-A	YHR086W-A	hom	Uncharacterized	0.265835763453941	0.395182849320024	no	1875	0.388584850409455	1272	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YML038C	YML038C	YMD8	hom	Verified	0.265639166979448	0.395258559038999	no	1876	0.397113142583814	1301	NA	FT		ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Putative nucleotide sugar transporter, has similarity to Vrg4p	UDP-glucose transport|nucleotide-sugar transport	nucleotide-sugar transmembrane transporter activity	COPI-coated vesicle|integral to membrane
YDR344C_d	YDR344C	YDR344C	hom	Dubious	0.263734370281695	0.395992304617324	no	1877	0.387951332812779	1289	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YGR262C	YGR262C	BUD32	hom	Verified	0.263017740370068	0.396268452773287	no	1878	0.452567490003108	1505	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|LIPID METABOLISM|CELL DIVISION|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION	NUCLEUS|CHROMOSOME		Protein kinase, component of the EKC/KEOPS complex with Kae1p, Cgi121p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription	threonylcarbamoyladenosine metabolic process|protein phosphorylation|telomere maintenance|cellular bud site selection|positive regulation of transcription from RNA polymerase II promoter	protein serine/threonine kinase activity	EKC/KEOPS complex|nucleus|cytoplasm
YJL068C	YJL068C	YJL068C	hom	Verified	0.261056684654776	0.39702439715526	no	1879	0.389060839335579	1289	NA					Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D	formaldehyde catabolic process	S-formylglutathione hydrolase activity	cytosol
YBL106C	YBL106C	SRO77	hom	Verified	0.261048059903122	0.397027722666654	no	1880	0.46861874917423	1572	NA	FF|FT	VESICLE-MEDIATED TRANSPORT	PLASMA MEMBRANE		Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lethal giant larvae tumor suppressor; interacts with SNARE protein Sec9p; SRO77 has a paralog, SRO7, that arose from the whole genome duplication	exocytosis|Golgi to plasma membrane transport	molecular_function	plasma membrane
YMR243C	YMR243C	ZRC1	hom	Verified	0.26028590847568	0.397321620753991	no	1881	0.402515696892403	1312	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Vacuolar membrane zinc transporter; transports zinc from cytosol to vacuole for storage; also has role in resistance to zinc shock resulting from sudden influx of zinc into cytoplasm; human ortholog SLC30A10 functions as a Mn transporter and mutations in SLC30A10 cause neurotoxic accumulation of Mn in liver and brain; ZRC1 has a paralog, COT1, that arose from the whole genome duplication	cobalt ion transport|cellular zinc ion homeostasis|zinc ion transport|glutathione metabolic process	zinc ion transmembrane transporter activity|inorganic cation transmembrane transporter activity	integral to membrane|fungal-type vacuole
YJL115W	YJL115W	ASF1	hom	Verified	0.259837166695459	0.397494690224908	no	1882	0.357959560854015	1211	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS		Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition	DNA replication-independent nucleosome assembly|histone acetylation|nucleosome disassembly|histone exchange|positive regulation of histone acetylation|chromatin silencing at silent mating-type cassette|chromatin silencing at telomere|DNA replication-dependent nucleosome assembly|regulation of transcription from RNA polymerase II promoter in response to stress	histone binding	chromatin assembly complex
YBL012C_d	YBL012C	YBL012C	hom	Dubious	0.258579236153734	0.397979952822104	no	1883	0.397456602135714	1310	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDL089W	YDL089W	NUR1	hom	Verified	0.256610892299376	0.398739582837283	no	1884	0.403632087928072	1345	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS		Protein of unknown function; interacts with Csm1p, Lrs4p; required for rDNA repeat stability; null mutant causes increase in unequal sister-chromatid exchange; GFP-fusion protein localizes to the nuclear periphery, possible Cdc28p substrate	maintenance of rDNA	molecular_function	nuclear periphery
YDR520C_p	YDR520C	URC2	hom	Uncharacterized	0.255868901387733	0.399026034268612	no	1885	0.427716372550342	1398	NA	FT	TRANSCRIPTION FROM RNA POL II|NUCLEOTIDE METABOLISM	NUCLEUS		Putative Zn(II)2Cys6 motif containing transcription factor; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; similar to S. kluyveri Urc2p involved in uracil catabolism	uracil catabolic process	sequence-specific DNA binding	nucleus|cytoplasm
YJR053W	YJR053W	BFA1	hom	Verified	0.254560582069811	0.399531253646698	no	1886	0.381642568048246	1254	NA	FT	CELL CYCLE|CELL DIVISION	CYTOSKELETON		Component of the GTPase-activating Bfa1p-Bub2p complex involved in multiple cell cycle checkpoint pathways that control exit from mitosis	regulation of exit from mitosis|mitotic cell cycle spindle orientation checkpoint	GTPase activator activity	spindle pole body
YPR118W	YPR118W	MRI1	hom	Verified	0.25305100858497	0.40011439820797	no	1887	0.406080881800862	1338	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		5'-methylthioribose-1-phosphate isomerase; catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway	L-methionine salvage from methylthioadenosine	S-methyl-5-thioribose-1-phosphate isomerase activity	nucleus|cytoplasm
YOR380W	YOR380W	RDR1	hom	Verified	0.251551639602729	0.40069382134663	no	1888	0.38984105743422	1279	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Transcriptional repressor involved in the control of multidrug resistance; negatively regulates expression of the PDR5 gene; member of the Gal4p family of zinc cluster proteins	response to xenobiotic stimulus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	nucleus
YBL070C_d	YBL070C	YBL070C	hom	Dubious	0.251344924682475	0.400773722396545	no	1889	0.406051672286018	1344	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YDR223W	YDR223W	CRF1	hom	Verified	0.250223357039165	0.401207311683321	no	1890	0.400501360130981	1312	NA	FT	TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS	NUCLEUS|CHROMOSOME		Transcriptional corepressor involved in repression of ribosomal protein (RP) gene transcription via the TOR signaling pathway which promotes accumulation of Crf1p in the nucleus; role in repression of RP genes varies by strain	negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter	transcription corepressor activity	nuclear chromatin|nucleus|cytoplasm
YNL277W-A_p	YNL277W-A	YNL277W-A	hom	Uncharacterized	0.250028738724444	0.401282562008537	no	1891	0.385356417195862	1300	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YDL204W	YDL204W	RTN2	hom	Verified	0.249645434966073	0.401430779384649	no	1892	0.403712706225223	1324	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Reticulon protein; stabilizes membrane curvature; involved in nuclear pore assembly and maintenance of tubular ER morphology; interacts with exocyst subunit Sec6p, Yip3p, and Sbh1p; much less abundant than Rtn1p; rtn1 rtn2 yop1 triple mutant lacks tubular ER; member of RTNLA (reticulon-like A) subfamily; protein increases in abundance and relocalizes to plasma membrane upon DNA replication stress; RTN2 has a paralog, RTN1, that arose from the whole genome duplication	endoplasmic reticulum tubular network organization|endoplasmic reticulum tubular network maintenance	molecular_function	endoplasmic reticulum|cortical endoplasmic reticulum|endoplasmic reticulum tubular network
YNR041C	YNR041C	COQ2	hom	Verified	0.249330997635455	0.401552377815768	no	1893	0.402340074811422	1340	NA	FT	KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM	MITOCHONDRION		Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis	ubiquinone biosynthetic process	4-hydroxybenzoate octaprenyltransferase activity	mitochondrion|integral to mitochondrial membrane|integral to membrane
YDR458C	YDR458C	HEH2	hom	Verified	0.248355616096806	0.401929635569248	no	1894	0.408762251549531	1344	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS		Inner nuclear membrane (INM) protein; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence; targeting to the INM requires the Srp1p-Kap95p karyopherins and the Ran cycle	biological_process	molecular_function	nuclear envelope
YGL009C	YGL009C	LEU1	hom	Verified	0.248046020154759	0.40204940011236	no	1895	0.402103591814419	1324	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway	leucine biosynthetic process	3-isopropylmalate dehydratase activity	cytosol
YDR314C	YDR314C	RAD34	hom	Verified	0.247470287280897	0.402272141899404	no	1896	0.423069774551066	1381	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Protein involved in nucleotide excision repair (NER); homologous to RAD4	nucleotide-excision repair	molecular_function	nucleus
YDL210W	YDL210W	UGA4	hom	Verified	0.245191723221445	0.403153992369483	no	1897	0.390263128738284	1260	NA					Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane	gamma-aminobutyric acid transport|putrescine transport|transmembrane transport	putrescine transmembrane transporter activity|gamma-aminobutyric acid:hydrogen symporter activity	fungal-type vacuole membrane|integral to membrane
YGR015C_p	YGR015C	YGR015C	hom	Uncharacterized	0.244344376860934	0.403482058523393	no	1898	0.415269028877211	1376	NA	FT		MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion	biological_process	molecular_function	mitochondrion
YNL318C	YNL318C	HXT14	hom	Verified	0.243567542296099	0.40378288439583	no	1899	0.381987671189345	1249	NA	FT		MITOCHONDRION|PLASMA MEMBRANE		Protein with similarity to hexose transporter family members, expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	hexose transport	galactose transmembrane transporter activity	mitochondrion|integral to membrane|plasma membrane
YPL188W	YPL188W	POS5	hom	Verified	0.243278813240345	0.403894708011165	no	1900	0.406547774034734	1331	NA	FT	NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS	MITOCHONDRION		Mitochondrial NADH kinase, phosphorylates NADH; also phosphorylates NAD(+) with lower specificity; required for the response to oxidative stress	cellular response to oxidative stress|NADP biosynthetic process	NADH kinase activity	mitochondrion|mitochondrial matrix
YBL039C	YBL039C	URA7	hom	Verified	0.242587368541665	0.40416253370684	no	1901	0.388690907363357	1280	NA	FT	KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM			Major CTP synthase isozyme (see also URA8); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA7 has a paralog, URA8, that arose from the whole genome duplication	pyrimidine nucleobase biosynthetic process|CTP biosynthetic process|phospholipid biosynthetic process	CTP synthase activity	cytosol
YML052W	YML052W	SUR7	hom	Verified	0.241081279371346	0.404746060911766	no	1902	0.387370320399971	1302	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	MITOCHONDRION|PLASMA MEMBRANE		Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants	endocytosis|ascospore formation	molecular_function	cell cortex|eisosome|mitochondrion|membrane raft|integral to membrane|plasma membrane|actin cortical patch
YPL054W	YPL054W	LEE1	hom	Verified	0.240688945621735	0.404898103629892	no	1903	0.377337152754591	1248	NA					Zinc-finger protein of unknown function	biological_process	molecular_function	cellular_component
YDR368W	YDR368W	YPR1	hom	Verified	0.240554462479843	0.404950223742664	no	1904	0.405833472523359	1364	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		NADPH-dependent aldo-keto reductase; reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases; protein abundance increases in response to DNA replication stress; YPR1 has a paralog, GCY1, that arose from the whole genome duplication	cellular response to oxidative stress|D-xylose catabolic process|arabinose catabolic process	glucose 1-dehydrogenase (NADP+) activity|alditol:NADP+ 1-oxidoreductase activity|carbonyl reductase (NADPH) activity	nucleus|cytoplasm
YPR130C_d	YPR130C	YPR130C	hom	Dubious	0.240443323241625	0.404993297994834	no	1905	0.406374947869592	1350	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YNL338W_d	YNL338W	YNL338W	hom	Dubious	0.239945978369363	0.405186068119549	no	1906	0.397004092424519	1316	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps TEL14L-XC, which is Telomeric X element Core sequence on the left arm of Chromosome XIV	Unknown	Unknown	Unknown
YPR129W	YPR129W	SCD6	hom	Verified	0.239744108981783	0.405264318957252	no	1907	0.418602733987053	1387	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION			Repressor of translation initiation; binds eIF4G through its RGG domain and inhibits recruitment of the preinitiation complex; also contains an Lsm domain; may have a role in RNA processing; overproduction suppresses null mutation in clathrin heavy chain gene CHC1; forms cytoplasmic foci upon DNA replication stress	stress granule assembly|negative regulation of translational initiation|cytoplasmic mRNA processing body assembly	mRNA binding|RNA binding|eukaryotic initiation factor 4G binding	cytoplasmic mRNA processing body|cytoplasmic stress granule|cytoplasm
YJR092W	YJR092W	BUD4	hom	Verified	0.239201834868422	0.405474539970412	no	1908	0.404161648193245	1328	NA	FT	CELL CYCLE|CELL DIVISION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Anillin-like protein involved in bud-site selection; required for the axial budding pattern; localizes with septins to the bud neck in mitosis and may constitute an axial landmark for the next round of budding; required for the formation and disassembly of the double septin ring structure, and generally for septin organization; in vivo substrate of Cdc28p/Clb2p	cellular bud site selection|axial cellular bud site selection	GTP binding	cellular bud neck contractile ring
YAL013W	YAL013W	DEP1	hom	Verified	0.238974847658612	0.405562543200448	no	1909	0.415930276260134	1366	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|CHROMOSOME		Transcriptional modulator involved in regulation of structural phospholipid biosynthesis genes and metabolically unrelated genes, as well as maintenance of telomeres, mating efficiency, and sporulation	positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of chromatin silencing at rDNA|regulation of transcription from RNA polymerase II promoter|histone deacetylation|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of chromatin silencing at telomere|negative regulation of transcription from RNA polymerase II promoter|regulation of DNA-dependent DNA replication initiation|Unknown	molecular_function	Rpd3L-Expanded complex|Rpd3L complex
YBR161W	YBR161W	CSH1	hom	Verified	0.238645898580851	0.405690085647256	no	1910	0.390510690115363	1315	NA	FT	LIPID METABOLISM			Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Sur1p; CSH1 has a paralog, SUR1, that arose from the whole genome duplication	glycosphingolipid biosynthetic process|sphingolipid biosynthetic process	mannosyltransferase activity|transferase activity, transferring glycosyl groups	integral to membrane|fungal-type vacuole
YMR001C-A_p	YMR001C-A	YMR001C-A	hom	Uncharacterized	0.238621221393242	0.405699654063663	no	1911	0.400920154939757	1305	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YGR042W	YGR042W	YGR042W	hom	Verified	0.238369482063492	0.405797267543239	no	1912	0.397717320629224	1309	NA	FT		NUCLEUS		Protein of unknown function; involved in maintenance of proper telomere length; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; forms nuclear foci upon DNA replication stress	biological_process	molecular_function	nucleus|cytoplasm
YBL083C_d	YBL083C	YBL083C	hom	Dubious	0.2372332881122	0.406237906559561	no	1913	0.415011277187642	1365	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified ORF ALG3	Unknown	Unknown	Unknown
YER176W	YER176W	ECM32	hom	Verified	0.236782282936625	0.406412848461312	no	1914	0.388025075951167	1305	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION			DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes	regulation of translational termination	RNA helicase activity|DNA helicase activity	polysome
YKR069W	YKR069W	MET1	hom	Verified	0.236697556331206	0.40644571543248	no	1915	0.407519095182887	1346	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM			S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis	siroheme biosynthetic process|methionine biosynthetic process|sulfate assimilation	uroporphyrin-III C-methyltransferase activity	intracellular
YLR425W	YLR425W	TUS1	hom	Verified	0.236285160798611	0.406605700470447	no	1916	0.470874445720035	1558	NA	FT	SIGNALING|CELL WALL ORG/BIOGENESIS	SITE OF POLARIZED GROWTH		Guanine nucleotide exchange factor (GEF) that modulate Rho1p activity; involved in the cell integrity signaling pathway; interacts with Rgl1p; localization of Tus1p to the bed neck is regulated by Rgl1p; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate	fungal-type cell wall organization|signal transduction	Rho guanyl-nucleotide exchange factor activity	incipient cellular bud site|cellular bud neck
YPR052C	YPR052C	NHP6A	hom	Verified	0.234467042914754	0.407311208037666	no	1917	0.402372980946185	1320	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		High-mobility group (HMG) protein, binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to chromosomes; functionally redundant with Nhp6Bp; homologous to mammalian HMGB1 and HMGB2; NHP6A has a paralog, NHP6B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	mismatch repair|DNA replication-independent nucleosome organization|RNA polymerase II transcriptional preinitiation complex assembly|RNA polymerase III transcriptional preinitiation complex assembly|chromatin remodeling	nucleosome binding|sequence-specific DNA binding|DNA binding, bending	MutSalpha complex|nucleus
YHR047C	YHR047C	AAP1	hom	Verified	0.23443141410136	0.407325036554841	no	1918	0.374991796074776	1249	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEOLYSIS|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS		Arginine/alanine amino peptidase; overproduction stimulates glycogen accumulation; AAP1 has a paralog, APE2, that arose from the whole genome duplication	glycogen metabolic process|proteolysis	aminopeptidase activity	nucleus|cytoplasm
YHR163W	YHR163W	SOL3	hom	Verified	0.232737876422693	0.407982477788481	no	1919	0.407521632434849	1318	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		6-phosphogluconolactonase; catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p; SOL3 has a paralog, SOL4, that arose from the whole genome duplication	pentose-phosphate shunt, oxidative branch	6-phosphogluconolactonase activity	nucleus|cytoplasm
YNL044W	YNL044W	YIP3	hom	Verified	0.231741620896724	0.408369351206421	no	1920	0.409915653084459	1349	NA	FT	VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Protein localized to COPII vesicles, proposed to be involved in ER to Golgi transport; interacts with members of the Rab GTPase family and Yip1p; also interacts with Rtn1p	ER to Golgi vesicle-mediated transport	molecular_function	Golgi apparatus|endoplasmic reticulum|ER to Golgi transport vesicle
YDR524C	YDR524C	AGE1	hom	Verified	0.231438449588883	0.408487098707347	no	1921	0.356556535639501	1201	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM	GOLGI APPARATUS		ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif	ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport	phospholipid binding|ARF GTPase activator activity	endosome|trans-Golgi network|cytoplasm
YMR145C	YMR145C	NDE1	hom	Verified	0.229841568974005	0.409107440961656	no	1922	0.413033825678806	1358	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial external NADH dehydrogenase, a type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain	glucose catabolic process to ethanol|NADH oxidation|chronological cell aging	NADH dehydrogenase activity	mitochondrion
YAL062W	YAL062W	GDH3	hom	Verified	0.229414880911936	0.409273235634343	no	1923	0.402554345559203	1343	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	NUCLEUS|MITOCHONDRION		NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources; GDH3 has a paralog, GDH1, that arose from the whole genome duplication	glutamate biosynthetic process|ammonia assimilation cycle	glutamate dehydrogenase (NADP+) activity	mitochondrion|nucleus
YNL054W	YNL054W	VAC7	hom	Verified	0.228805180598117	0.40951017003128	no	1924	0.342837300343782	1164	NA	FT	LIPID METABOLISM			Integral vacuolar membrane protein involved in vacuole inheritance and morphology; activates Fab1p kinase activity under basal conditions and also after hyperosmotic shock	positive regulation of phosphatidylinositol biosynthetic process|positive regulation of kinase activity	molecular_function	fungal-type vacuole membrane|integral to membrane|PAS complex|vacuolar membrane|cytoplasm
YGR182C_d	YGR182C	YGR182C	hom	Dubious	0.228262567092321	0.409721061762631	no	1925	0.394794602812755	1316	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TIM13/YGR181W	Unknown	Unknown	Unknown
YAL020C	YAL020C	ATS1	hom	Verified	0.227513038341849	0.410012415958696	no	1926	0.413971822874407	1371	NA	FT	RNA PROCESSING|CELL DIVISION|CYTOSKELETON ORGANIZATION			Protein required, with Elongator complex, Kti11p, and Kti12p, for modification of wobble nucleosides in tRNA; has a potential role in regulatory interactions between microtubules and the cell cycle	microtubule-based process|budding cell bud growth|microtubule cytoskeleton organization|tRNA wobble uridine modification	molecular_function	cytoplasm
YGL146C_p	YGL146C	RRT6	hom	Uncharacterized	0.227347332856915	0.410076835127853	no	1927	0.396592288282218	1309	NA					Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins	biological_process	molecular_function	membrane
YOL138C	YOL138C	RTC1	hom	Verified	0.227181268125698	0.410141396391307	no	1928	0.411641403545877	1385	NA					Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; null mutation suppresses cdc13-1 temperature sensitivity; has N-terminal WD-40 repeats and a C-terminal RING motif	biological_process	molecular_function	ribosome|fungal-type vacuole|Seh1-associated complex|extrinsic to fungal-type vacuolar membrane
YMR285C	YMR285C	NGL2	hom	Verified	0.225949298221746	0.410620427340883	no	1929	0.396776633531099	1276	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p; NGL2 has a paralog, NGL3, that arose from the whole genome duplication	rRNA processing	endoribonuclease activity	intracellular
YMR023C	YMR023C	MSS1	hom	Verified	0.224591049981321	0.41114871405639	no	1930	0.390285855207618	1278	NA	FT	RNA PROCESSING|SIGNALING|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial protein, forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; similar to human GTPBP3	mitochondrial tRNA wobble uridine modification|Unknown	GTP binding	mitochondrion|mitochondrial inner membrane
YML080W	YML080W	DUS1	hom	Verified	0.223382725149032	0.411618823999735	no	1931	0.368976165550717	1223	NA	FT	RNA PROCESSING|OXIDATION-REDUCTION PROCESS	NUCLEUS		Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNA(Phe) at U17	tRNA modification	tRNA dihydrouridine synthase activity	nucleus
YHR038W	YHR038W	RRF1	hom	Verified	0.22227449039666	0.412050104563865	no	1932	0.418773608065063	1391	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial ribosome recycling factor, essential for mitochondrial protein synthesis and for the maintenance of the respiratory function of mitochondria	mitochondrial translation	translation release factor activity	mitochondrion
YIR036C_p	YIR036C	IRC24	hom	Uncharacterized	0.221804823770193	0.412232912082953	no	1933	0.413622955692515	1374	NA	FT	OXIDATION-REDUCTION PROCESS			Putative benzil reductase;(GFP)-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS; sequence similarity with short-chain dehydrogenase/reductases; null mutant has increased spontaneous Rad52p foci	biological_process	molecular_function	integral to membrane|cytoplasm
YBR017C	YBR017C	KAP104	hom	Verified	0.221698092111567	0.412274457716763	no	1934	0.393553292824062	1310	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE	SITE OF POLARIZED GROWTH		Transportin or cytosolic karyopherin beta 2; functions in the rg-nuclear localization signal-mediated nuclear import/reimport of mRNA-binding proteins Nab2p and Hrp1p; regulates asymmetric protein synthesis in daughter cells during mitosis	protein import into nucleus|cell cycle|mRNA-binding (hnRNP) protein import into nucleus|transcription factor import into nucleus	nuclear localization sequence binding	cytosol|integral to membrane|cellular bud neck|cellular bud tip
YJR033C	YJR033C	RAV1	hom	Verified	0.221568716691169	0.412324818824063	no	1935	0.422065625170529	1387	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM		Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate	early endosome to late endosome transport|vacuolar acidification|regulation of protein complex assembly	molecular_function	RAVE complex|cytoplasm|extrinsic to membrane
YJL095W	YJL095W	BCK1	hom	Verified	0.220882226524904	0.412592068408283	no	1936	0.441599251855103	1449	NA	FF|FT	SIGNALING|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION	SITE OF POLARIZED GROWTH		Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p	intracellular protein kinase cascade|endoplasmic reticulum unfolded protein response|peroxisome degradation|establishment of cell polarity|protein phosphorylation|response to acid|response to nutrient	protein kinase activity|MAP kinase kinase kinase activity	intracellular|mating projection tip
YLL025W	YLL025W	PAU17	hom	Verified	0.220669632899358	0.412674839009582	no	1937	0.395492769937183	1297	NA					Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; YLL025W is not an essential gene	biological_process	molecular_function	cellular_component
YPL222W_p	YPL222W	FMP40	hom	Uncharacterized	0.219665482929103	0.413065844347517	no	1938	0.416849983315522	1366	NA	FT		MITOCHONDRION		Putative protein of unknown function; proposed to be involved in responding to environmental stresses; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YOL125W	YOL125W	TRM13	hom	Verified	0.218554832955897	0.413498420104457	no	1939	0.392112085853719	1300	NA	FT	RNA PROCESSING	NUCLEUS		2'-O-methyltransferase responsible for modification of tRNA at position 4; C-terminal domain has similarity to Rossmann-fold (RFM) superfamily of RNA methyltransferases	tRNA methylation	tRNA methyltransferase activity	nucleus|cytoplasm
YGR027C	YGR027C	RPS25A	hom	Verified	0.218102894525764	0.413674471093993	no	1940	0.424288146517466	1415	NA	FT	TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S25, no bacterial homolog; RPS25A has a paralog, RPS25B, that arose from the whole genome duplication	cytoplasmic translation	structural constituent of ribosome	cytosolic small ribosomal subunit
YDR307W_p	YDR307W	PMT7	hom	Uncharacterized	0.216316775795497	0.414370416711444	no	1941	0.413096512732139	1362	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Putative protein mannosyltransferase similar to Pmt1p; has a potential role in protein O-glycosylation	biological_process	molecular_function	integral to membrane|endoplasmic reticulum
YIL159W	YIL159W	BNR1	hom	Verified	0.216261900327338	0.414391802729156	no	1942	0.410745974697546	1373	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH		Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNI1	barbed-end actin filament capping|actin filament bundle assembly|formin-nucleated actin cable assembly	profilin binding	cellular bud neck
YCR067C	YCR067C	SED4	hom	Verified	0.215388771022232	0.414732111994947	no	1943	0.413492706042962	1353	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Integral endoplasmic reticulum membrane protein that stimulates Sar1p GTPase activity; involved in COPII vesicle budding through disassociation of coat proteins from membranes onto liposomes; binds Sec16p; similar to Sec12p	positive regulation of GTPase activity|regulation of COPII vesicle coating	Sar GTPase activator activity	integral to endoplasmic reticulum membrane
YOR137C	YOR137C	SIA1	hom	Verified	0.214521355149942	0.415070257782716	no	1944	0.393649633270543	1285	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Protein of unassigned function involved in activation of the Pma1p plasma membrane H+-ATPase by glucose	proton transport	molecular_function	cellular_component
YDR521W_d	YDR521W	YDR521W	hom	Dubious	0.21402012952054	0.415265679883604	no	1945	0.401055758033646	1316	NA					Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol	Unknown	Unknown	Unknown
YMR060C	YMR060C	SAM37	hom	Verified	0.213493851879387	0.415470892037001	no	1946	0.446823519087873	1494	NA	FT	PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; contributes to SAM complex stability	mitochondrial outer membrane translocase complex assembly|protein import into mitochondrial outer membrane|phospholipid transport	molecular_function	mitochondrial outer membrane|mitochondrial sorting and assembly machinery complex|mitochondrion|integral to membrane
YHR066W	YHR066W	SSF1	hom	Verified	0.212896542727668	0.415703829537169	no	1947	0.389419548683805	1276	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS	NUCLEUS		Constituent of 66S pre-ribosomal particles; required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family; SSF1 has a paralog, SSF2, that arose from the whole genome duplication	conjugation with cellular fusion|ribosomal large subunit assembly|regulation of cell size	rRNA binding	nucleolus
YKR035W-A	YKR035W-A	DID2	hom	Verified	0.212825337652345	0.415731599936334	no	1948	0.414635873721935	1362	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT	ENDOMEMBRANE SYSTEM		Class E protein of the vacuolar protein-sorting (Vps) pathway; binds Vps4p and directs it to dissociate ESCRT-III complexes; forms a functional and physical complex with Ist1p; human ortholog may be altered in breast tumors	late endosome to vacuole transport via multivesicular body sorting pathway|late endosome to vacuole transport|protein targeting to vacuole	molecular_function	late endosome|cytoplasm
YOR087W	YOR087W	YVC1	hom	Verified	0.21218213164341	0.415982473126195	no	1949	0.41945969389227	1376	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS			Vacuolar cation channel, mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock	cellular cation homeostasis	voltage-gated ion channel activity|calcium activated cation channel activity|sodium channel activity|calcium channel activity|potassium channel activity	fungal-type vacuole membrane|fungal-type vacuole
YBR217W	YBR217W	ATG12	hom	Verified	0.212030481486366	0.416041627065865	no	1950	0.408675025268471	1334	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Conserved ubiquitin-like modifier involved in autophagy and the Cvt pathway; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg12p-Atg5p also forms a complex with Atg16p that is required for autophagosome formation	C-terminal protein lipidation|piecemeal microautophagy of nucleus|mitochondrion degradation|CVT pathway|autophagic vacuole assembly	Atg8 ligase activity|protein tag	Atg12-Atg5-Atg16 complex|pre-autophagosomal structure
YNL071W	YNL071W	LAT1	hom	Verified	0.211970450838277	0.416065043652483	no	1951	0.436297826166839	1435	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA	acetyl-CoA biosynthetic process from pyruvate	dihydrolipoyllysine-residue acetyltransferase activity	mitochondrion|mitochondrial pyruvate dehydrogenase complex
YKR044W	YKR044W	UIP5	hom	Verified	0.211526690510191	0.416238153672366	no	1952	0.413006471524825	1367	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS		Protein of unknown function that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates	biological_process	molecular_function	nuclear envelope
YDR233C	YDR233C	RTN1	hom	Verified	0.211419286529531	0.416280054194956	no	1953	0.411460239110605	1353	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS		Reticulon protein; stabilizes membrane curvature; involved in nuclear pore assembly and maintenance of tubular ER morphology; mutant overexpressing RTN1 shows increase in tubular ER; interacts with exocyst subunit Sec6p, Yip3p, and Sbh1p; more abundant than Rtn2p; member of the RTNLA subfamily; mutants have reduced phosphatidylserine transfer between the ER and mitochondria; RTN1 has a paralog, RTN2, that arose from the whole genome duplication	endoplasmic reticulum tubular network organization|endoplasmic reticulum organization|endoplasmic reticulum tubular network maintenance|nuclear pore complex assembly	molecular_function	integral to endoplasmic reticulum membrane|mitochondrion|Golgi apparatus|endoplasmic reticulum|cortical endoplasmic reticulum|endoplasmic reticulum tubular network
YMR195W	YMR195W	ICY1	hom	Verified	0.210726946357692	0.41655017328341	no	1954	0.400777957984348	1322	NA					Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation	biological_process	molecular_function	fungal-type vacuole membrane
YIL116W	YIL116W	HIS5	hom	Verified	0.207569269594527	0.417782650522697	no	1955	0.421768976572618	1420	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Histidinol-phosphate aminotransferase, catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts	histidine biosynthetic process	histidinol-phosphate transaminase activity	intracellular
YBL002W	YBL002W	HTB2	hom	Verified	0.206901759006051	0.41804329137708	no	1956	0.411762642129182	1343	NA	FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB1; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation	chromatin assembly or disassembly	DNA binding	replication fork protection complex|nuclear nucleosome
YDR321W	YDR321W	ASP1	hom	Verified	0.206057697398923	0.418372921104194	no	1957	0.408609853930878	1381	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			Cytosolic L-asparaginase, involved in asparagine catabolism; catalyzes hydrolysis of L-asparagine to aspartic acid and ammonia, has an important role in therapy of acute lymphoblastic leukemia; synthesized constitutively	asparagine catabolic process	asparaginase activity	intracellular
YFL018C	YFL018C	LPD1	hom	Verified	0.205418277318972	0.418622670757973	no	1958	0.390718184194467	1302	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Dihydrolipoamide dehydrogenase, the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes	L-serine biosynthetic process|2-oxoglutarate metabolic process|leucine catabolic process|glycine catabolic process|isoleucine catabolic process|pyruvate metabolic process|valine catabolic process|hydrogen peroxide metabolic process	glycine dehydrogenase (decarboxylating) activity|pyruvate dehydrogenase activity|oxoglutarate dehydrogenase (succinyl-transferring) activity|dihydrolipoyl dehydrogenase activity	mitochondrial nucleoid|mitochondrion|glycine cleavage complex|mitochondrial oxoglutarate dehydrogenase complex
YGL167C	YGL167C	PMR1	hom	Verified	0.205024781053459	0.418776381893853	no	1959	0.439083021258711	1463	NA	FT	VESICLE-MEDIATED TRANSPORT|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease	manganese ion transport|calcium ion transport|exocytosis	manganese-transporting ATPase activity|calcium-transporting ATPase activity|calcium ion binding	integral to membrane|Golgi membrane
YPL250C	YPL250C	ICY2	hom	Verified	0.204610969986002	0.418938041962632	no	1960	0.449584030831417	1477	NA					Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate	mitochondrion degradation	molecular_function	cellular_component
YNR031C	YNR031C	SSK2	hom	Verified	0.204595426402711	0.418944114509717	no	1961	0.421144506192888	1387	NA	FT	SIGNALING|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH		MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress	MAPK cascade involved in osmosensory signaling pathway|protein autophosphorylation|protein phosphorylation|response to osmotic stress|actin cytoskeleton organization|osmosensory signaling pathway via two-component system	MAP kinase kinase kinase activity	cytosol|cellular bud neck|cellular bud tip
YOL079W_d	YOL079W	YOL079W	hom	Dubious	0.204503531359199	0.418980016341408	no	1962	0.436675074664697	1429	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YKR052C	YKR052C	MRS4	hom	Verified	0.203993152409567	0.419179424994475	no	1963	0.391417389079381	1274	NA	FT	RNA PROCESSING|ION HOMEOSTASIS|ION HOMEOSTASIS	MITOCHONDRION		Iron transporter of the mitochondrial carrier family; mediates Fe2+ transport across the inner mitochondrial membrane; active under low-iron conditions; may transport other cations; protein abundance increases in response to DNA replication stress; MRS4 has a paralog, MRS3, that arose from the whole genome duplication	mitochondrial iron ion transport|RNA splicing	iron ion transmembrane transporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YDR442W_d	YDR442W	YDR442W	hom	Dubious	0.203670429655863	0.419305525767107	no	1964	0.435152109261681	1440	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YMR316C-B_d	YMR316C-B	YMR316C-B	hom	Dubious	0.203186521916667	0.419494623531286	no	1965	0.388092222715251	1265	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YER110C	YER110C	KAP123	hom	Verified	0.203033211507708	0.419554536880566	no	1966	0.383947989049616	1309	NA	FT	PROTEIN LOCALIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS	NUCLEAR PORE	Karyopherin beta, mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1	NLS-bearing substrate import into nucleus|Unknown|protein import into nucleus|ribosomal protein import into nucleus	protein transporter activity|nuclear localization sequence binding	integral to membrane|nucleus|nuclear pore|cytoplasm
YOR360C	YOR360C	PDE2	hom	Verified	0.20205180210405	0.419938113503643	no	1967	0.442589696242921	1440	NA	FT	SIGNALING	NUCLEUS		High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon	cAMP-mediated signaling	3',5'-cyclic-AMP phosphodiesterase activity	nucleus|cytoplasm
YJR096W	YJR096W	YJR096W	hom	Verified	0.201080139655123	0.420317955542138	no	1968	0.427792835796292	1424	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS	NUCLEUS		Putative xylose and arabinose reductase; member of the aldo-keto reductase (AKR) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS	cellular response to oxidative stress|D-xylose catabolic process|arabinose catabolic process	alditol:NADP+ 1-oxidoreductase activity|aldo-keto reductase (NADP) activity	nucleus|cytoplasm
YLL053C_p	YLL053C	YLL053C	hom	Uncharacterized	0.200989111244773	0.420353544152948	no	1969	0.410828066266798	1361	NA					Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin	biological_process	molecular_function	integral to membrane
YMR172W	YMR172W	HOT1	hom	Verified	0.200144708447671	0.420683704198733	no	1970	0.405385877485394	1345	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Transcription factor required for the transient induction of glycerol biosynthetic genes GPD1 and GPP2 in response to high osmolarity; targets Hog1p to osmostress responsive promoters; has similarity to Msn1p and Gcr1p	cellular hyperosmotic salinity response|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly|sequence-specific DNA binding RNA polymerase II transcription factor activity	nucleus
YBL009W	YBL009W	ALK2	hom	Verified	0.198773917211709	0.421219799946753	no	1971	0.419174899624189	1386	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION			Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; ALK2 has a paralog, ALK1, that arose from the whole genome duplication; similar to mammalian haspins	meiosis|mitosis|protein phosphorylation	protein serine/threonine kinase activity|protein kinase activity	cellular_component
YGL104C	YGL104C	VPS73	hom	Verified	0.198721876817302	0.42124015504352	no	1972	0.434246878124867	1430	NA	FT	PROTEIN LOCALIZATION|VACUOLAR TRANSPORT	MITOCHONDRION		Mitochondrial protein; mutation affects vacuolar protein sorting; putative transporter; member of the sugar porter family	transport|transmembrane transport|protein targeting to vacuole	substrate-specific transmembrane transporter activity	mitochondrion|integral to membrane
YNL298W	YNL298W	CLA4	hom	Verified	0.198598152343531	0.42128854951943	no	1973	0.469483808982345	1541	NA	FF|FT	CELL CYCLE|SIGNALING|CELL DIVISION|PROTEIN PHOSPHORYLATION	NUCLEUS		Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p	negative regulation of gene expression|vacuole inheritance|protein phosphorylation|budding cell apical bud growth|Rho protein signal transduction|regulation of exit from mitosis|establishment of cell polarity|sterol import|response to pheromone|cytokinesis	protein serine/threonine kinase activity|protein kinase activity	nucleus|cellular bud|fungal-type vacuole
YBL060W	YBL060W	YEL1	hom	Verified	0.19789587589702	0.421563265463372	no	1974	0.431465889291405	1415	NA	FT	PROTEIN LOCALIZATION|LIPID METABOLISM|SIGNALING	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Guanine nucleotide exchange factor specific for Arf3p; localized to the bud neck and tip; required for localization of Arf3p to the bud neck and tip	positive regulation of phosphatidylinositol biosynthetic process|protein localization|actin cortical patch localization	ARF guanyl-nucleotide exchange factor activity	cellular bud neck|cellular bud tip|cytoplasm
YOR343C_d	YOR343C	YOR343C	hom	Dubious	0.197648027924836	0.421660227558927	no	1975	0.416910741229528	1371	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR281C_p	YLR281C	YLR281C	hom	Uncharacterized	0.19640407091136	0.422146955094041	no	1976	0.413883081758544	1380	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION	MITOCHONDRION		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR281C is not an essential gene	biological_process	molecular_function	mitochondrion
YAL019W	YAL019W	FUN30	hom	Verified	0.194415195415319	0.422925396346963	no	1977	0.421623264488838	1385	NA	FT	CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS|MITOCHONDRION|CHROMOSOME		Snf2p family member with ATP-dependent chromatin remodeling activity; has a role in silencing at the mating type locus, telomeres and centromeres; enriched at centromeres and is required for correct chromatin structure around centromeres, as well as at the boundary element of the silent HMR; recruited to DNA double-strand breaks (DSBs) where it promotes 5' strand resection of DSBs; potential Cdc28p substrate	chromosome organization|chromatin silencing at rDNA|heterochromatin maintenance involved in chromatin silencing|chromatin silencing at telomere|chromatin silencing at silent mating-type cassette|heterochromatin assembly involved in chromatin silencing	chromatin binding|DNA-dependent ATPase activity|DNA binding|protein homodimerization activity	mitochondrion|mating-type region heterochromatin|nucleus
YOL155C	YOL155C	HPF1	hom	Verified	0.19434621868589	0.422952399097432	no	1978	0.425055684889098	1411	NA	FT	CELL WALL ORG/BIOGENESIS			Haze-protective mannoprotein that reduces the particle size of aggregated proteins in white wines	fungal-type cell wall organization	glucosidase activity	fungal-type cell wall|extracellular region
YPR157W_p	YPR157W	TDA6	hom	Uncharacterized	0.193658919297064	0.423221480228968	no	1979	0.411614684697871	1351	NA	FT	PROTEIN LOCALIZATION			Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; null mutant is sensitive to expression of the top1-T722A allele	biological_process	molecular_function	cellular_component
YHR155W	YHR155W	YSP1	hom	Verified	0.193473311106574	0.423294152906869	no	1980	0.433026923640108	1416	NA	FF|FT		MITOCHONDRION		Mitochondrial protein; potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone; YSP1 has a paralog, SIP3, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrion
YPR065W	YPR065W	ROX1	hom	Verified	0.192617491130555	0.423629272753707	no	1981	0.425320040417111	1394	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS|CHROMOSOME		Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance	negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter in response to stress	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|DNA binding, bending|sequence-specific DNA binding|RNA polymerase II transcription factor recruiting transcription factor activity	nuclear chromatin
YGR021W_p	YGR021W	YGR021W	hom	Uncharacterized	0.192337471838965	0.423738934015086	no	1982	0.42949379807002	1450	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion
YOL019W_p	YOL019W	YOL019W	hom	Uncharacterized	0.191396859478861	0.42410734017934	no	1983	0.422222231969862	1388	NA	FT		PLASMA MEMBRANE		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole; YOL019W has a paralog, DCV1, that arose from the whole genome duplication	biological_process	molecular_function	integral to membrane|plasma membrane|fungal-type vacuole
YNL023C	YNL023C	FAP1	hom	Verified	0.191131506442315	0.424211282030871	no	1984	0.419222587948	1389	NA	FT		NUCLEUS		Protein that binds to Fpr1p, conferring rapamycin resistance by competing with rapamycin for Fpr1p binding; accumulates in the nucleus upon treatment of cells with rapamycin; has similarity to D. melanogaster shuttle craft and human NFX1	biological_process	sequence-specific DNA binding transcription factor activity	cytoplasm
YIR027C	YIR027C	DAL1	hom	Verified	0.190998250607308	0.424263481870581	no	1985	0.431847608581864	1432	NA					Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression	allantoin assimilation pathway	allantoinase activity	cellular_component
YML032C	YML032C	RAD52	hom	Verified	0.190497500738588	0.424459650725506	no	1986	0.431823275066458	1434	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE	NUCLEUS|CHROMOSOME		Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis	postreplication repair|telomere maintenance via recombination|meiotic joint molecule formation|meiotic DNA recombinase assembly|DNA recombinase assembly|DNA strand renaturation|double-strand break repair via synthesis-dependent strand annealing|double-strand break repair via single-strand annealing|double-strand break repair via break-induced replication	recombinase activity	nuclear chromosome|nucleus
YNR020C	YNR020C	ATP23	hom	Verified	0.189768942639078	0.424745096905289	no	1987	0.430757417833378	1440	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Putative metalloprotease of the mitochondrial inner membrane, required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex; substrate of the Mia40p-Erv1p disulfide relay system, and folding is assisted by Mia40p	protein processing|mitochondrial proton-transporting ATP synthase complex assembly	metalloendopeptidase activity	mitochondrial inner membrane|mitochondrial intermembrane space
YOR243C	YOR243C	PUS7	hom	Verified	0.189578330931714	0.424819784337476	no	1988	0.438454401362937	1446	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Pseudouridine synthase, catalyzes pseudouridylation at positions 35 and 56 in U2 snRNA, position 50 in 5S rRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); conserved in archaea, vertebrates, and some bacteria	snRNA pseudouridine synthesis|tRNA pseudouridine synthesis|enzyme-directed rRNA pseudouridine synthesis	pseudouridine synthase activity	nucleus
YLR280C_d	YLR280C	YLR280C	hom	Dubious	0.188886046615786	0.425091064953687	no	1989	0.396151194506275	1313	NA					Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YLR268W	YLR268W	SEC22	hom	Verified	0.18815133718742	0.42537900920282	no	1990	0.449270679306434	1477	NA	FF|FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog	retrograde vesicle-mediated transport, Golgi to ER|ER to Golgi vesicle-mediated transport|vesicle fusion with Golgi apparatus|vesicle fusion with endoplasmic reticulum|vesicle fusion	SNAP receptor activity	SNARE complex|integral to membrane|Golgi apparatus|endoplasmic reticulum|ER to Golgi transport vesicle membrane
YLR370C	YLR370C	ARC18	hom	Verified	0.187852529468878	0.425496128070773	no	1991	0.457004510517347	1512	NA	FF|FT	PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION	MITOCHONDRION|CYTOSKELETON		Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches	mitochondrion inheritance|actin filament organization|establishment of mitochondrion localization	molecular_function	mitochondrion|Arp2/3 protein complex
YBR231C	YBR231C	SWC5	hom	Verified	0.186858387001483	0.425885833411491	no	1992	0.425860478806045	1401	NA	FF|FT	CHROMATIN ORGANIZATION	NUCLEUS|CHROMOSOME		Component of the SWR1 complex; complex exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; protein abundance increases in response to DNA replication stress	chromatin remodeling|histone exchange	molecular_function	Swr1 complex|nucleus
YJR058C	YJR058C	APS2	hom	Verified	0.186809641649516	0.42590494352773	no	1993	0.402970211878952	1302	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMBRANE SYSTEM|PLASMA MEMBRANE		Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex	vesicle-mediated transport	molecular_function	AP-2 adaptor complex
YGR138C	YGR138C	TPO2	hom	Verified	0.186751830830207	0.425927607893209	no	1994	0.395685001125386	1313	NA	FT		PLASMA MEMBRANE		Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; TPO2 has a paralog, TPO3, that arose from the whole genome duplication	spermine transport	spermine transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|plasma membrane
YLL024C	YLL024C	SSA2	hom	Verified	0.185603089879575	0.426378015149023	no	1995	0.420987184593133	1381	NA	FT	PROTEIN LOCALIZATION	MITOCHONDRION		ATP binding protein involved in protein folding and vacuolar import of proteins; member of heat shock protein 70 (HSP70) family; associated with the chaperonin-containing T-complex; present in the cytoplasm, vacuolar membrane and cell wall; 98% identical with paralog Ssa1p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes	protein folding|SRP-dependent cotranslational protein targeting to membrane, translocation|response to stress	unfolded protein binding|ATPase activity|ATP binding	cytosol|fungal-type vacuole membrane|mitochondrion|fungal-type cell wall|plasma membrane|polysome|chaperonin-containing T-complex|cytoplasm
YKR011C	YKR011C	YKR011C	hom	Verified	0.185284511451132	0.426502942883877	no	1996	0.426154692138228	1393	NA	FT		NUCLEUS		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus
YDL083C	YDL083C	RPS16B	hom	Verified	0.184594988610749	0.42677335845142	no	1997	0.440699466817914	1455	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION		RIBOSOME	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16B has a paralog, RPS16A, that arose from the whole genome duplication	cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	structural constituent of ribosome	cytosolic small ribosomal subunit
YLR142W	YLR142W	PUT1	hom	Verified	0.183548192399689	0.427183954466151	no	1998	0.428157843054178	1419	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source	glutamate biosynthetic process|proline catabolic process to glutamate	proline dehydrogenase activity	mitochondrion
YJL128C	YJL128C	PBS2	hom	Verified	0.182252546382828	0.427692268702126	no	1999	0.45302344671564	1498	NA	FF|FT	PROTEIN LOCALIZATION|SIGNALING|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION	SITE OF POLARIZED GROWTH		MAP kinase kinase of the HOG signaling pathway; activated under severe osmotic stress; mitophagy-specific regulator; plays a role in regulating Ty1 transposition	activation of MAPK activity involved in osmosensory signaling pathway|actin filament organization|MAPK import into nucleus involved in osmosensory signaling pathway|protein phosphorylation|hyperosmotic response|osmosensory signaling pathway|cellular response to heat	MAP-kinase scaffold activity|MAP kinase kinase activity|protein kinase activity	cellular bud neck|cytoplasm|cellular bud tip
YOR079C	YOR079C	ATX2	hom	Verified	0.18104428366285	0.428166408482206	no	2000	0.416123198220197	1397	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Golgi membrane protein involved in manganese homeostasis; overproduction suppresses the sod1 (copper, zinc superoxide dismutase) null mutation	cellular manganese ion homeostasis	manganese ion transmembrane transporter activity	integral to membrane|Golgi membrane
YPR047W	YPR047W	MSF1	hom	Verified	0.180542874751557	0.428363199089421	no	2001	0.456761828928661	1531	NA	FT	KETONE METABOLISM|RNA PROCESSING|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial phenylalanyl-tRNA synthetase, active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase	phenylalanyl-tRNA aminoacylation|mitochondrial phenylalanyl-tRNA aminoacylation	phenylalanine-tRNA ligase activity	mitochondrion
YOR083W	YOR083W	WHI5	hom	Verified	0.180337029717998	0.428443993339315	no	2002	0.425893055987279	1393	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE	NUCLEUS		Repressor of G1 transcription that binds to SCB binding factor (SBF) at SCB target promoters in early G1; phosphorylation of Whi5p by the CDK, Cln3p/Cdc28p relieves repression and promoter binding by Whi5; periodically expressed in G1	negative regulation of transcription involved in G1/S phase of mitotic cell cycle|regulation of cell size	RNA polymerase II transcription factor recruiting transcription factor activity|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription	SBF transcription complex|nucleus|cytoplasm
YOR354C	YOR354C	MSC6	hom	Verified	0.177783356174685	0.429446559481391	no	2003	0.433233832214661	1432	NA	FT	CELL CYCLE	MITOCHONDRION		Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	reciprocal meiotic recombination	molecular_function	mitochondrion
YDR063W	YDR063W	AIM7	hom	Verified	0.177092994816872	0.429717672143541	no	2004	0.430487210788835	1424	NA	FT	CYTOSKELETON ORGANIZATION	NUCLEUS|CYTOSKELETON		Protein that interacts with Arp2/3 complex to stimulate actin filament debranching and inhibit actin nucleation; has similarity to Cof1p and also to human glia maturation factor (GMF); null mutant displays elevated mitochondrial genome loss	actin filament debranching|negative regulation of Arp2/3 complex-mediated actin nucleation	molecular_function	nucleus|actin cortical patch|cytoplasm
YDR034C	YDR034C	LYS14	hom	Verified	0.176812320842715	0.429827905451759	no	2005	0.440125932389556	1461	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM	NUCLEUS		Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer	Unknown|positive regulation of transcription from RNA polymerase II promoter	RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	nucleus
YJR124C_p	YJR124C	YJR124C	hom	Uncharacterized	0.176166633350406	0.430081516759613	no	2006	0.411482792939048	1345	NA					Putative protein of unknown function; expression induced under calcium shortage	biological_process	molecular_function	integral to membrane
YBR171W	YBR171W	SEC66	hom	Verified	0.17582720625484	0.430214847550191	no	2007	0.46741003855981	1841	NA	FF|FT	PROTEIN LOCALIZATION	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER	posttranslational protein targeting to membrane, translocation|filamentous growth	protein transporter activity	integral to membrane|Sec62/Sec63 complex|endoplasmic reticulum membrane
YIL016W	YIL016W	SNL1	hom	Verified	0.175732228941161	0.430252157135468	no	2008	0.427501292184856	1430	NA	FT		ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION		Ribosome-associated protein proposed to act in protein synthesis and nuclear pore complex biogenesis and maintenance as well as protein folding; has similarity to the mammalian BAG-1 protein	protein folding|nuclear pore organization	ribosome binding	nuclear envelope|mitochondrion|cytosolic ribosome|endoplasmic reticulum membrane|membrane
YBR116C_d	YBR116C	YBR116C	hom	Dubious	0.175222567504641	0.430452376172609	no	2009	0.4228296487772	1390	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TKL2	Unknown	Unknown	Unknown
YBR165W	YBR165W	UBS1	hom	Verified	0.175123508601404	0.430491293256359	no	2010	0.423785540820861	1395	NA	FT	PROTEIN LOCALIZATION	NUCLEUS		Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity	protein export from nucleus|protein ubiquitination	molecular_function	nucleus
YJR090C	YJR090C	GRR1	hom	Verified	0.174840282343305	0.430602567543487	no	2011	0.460346079184303	1521	NA	FT	CELL CYCLE|RESPONSE TO DNA DAMAGE|CARBOHYDRATE METABOLISM|PROTEOLYSIS	NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON	UBIQUITIN LIGASE COMPLEX	F-box protein component of the SCF ubiquitin-ligase complex; involved in carbon catabolite repression, glucose-dependent divalent cation transport, high-affinity glucose transport, morphogenesis, and sulfite detoxification	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular response to methylmercury|cell cycle arrest in response to pheromone|G1/S transition of mitotic cell cycle|response to DNA damage stimulus|protein ubiquitination	ubiquitin-protein ligase activity|protein binding, bridging	cellular bud neck contractile ring|SCF ubiquitin ligase complex|nucleus|cytoplasm
YBL099W	YBL099W	ATP1	hom	Verified	0.173377673544175	0.431177286632841	no	2012	0.434063273112088	1444	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS	MITOCHONDRION		Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated	ATP synthesis coupled proton transport	hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism	mitochondrial nucleoid|proton-transporting ATP synthase complex, catalytic core F(1)|mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase, catalytic core
YER153C	YER153C	PET122	hom	Verified	0.171843763452977	0.431780179497942	no	2013	0.436094142093251	1434	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet494p; located in the mitochondrial inner membrane	positive regulation of mitochondrial translation|mitochondrial respiratory chain complex IV biogenesis	translation initiation factor activity	mitochondrion|mitochondrial inner membrane|integral to mitochondrial inner membrane
YOR184W	YOR184W	SER1	hom	Verified	0.1710877175578	0.432077396725044	no	2014	0.436866718757124	1458	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM			3-phosphoserine aminotransferase; catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p; protein abundance increases in response to DNA replication stress	serine family amino acid biosynthetic process|L-serine biosynthetic process|purine nucleobase biosynthetic process	O-phospho-L-serine:2-oxoglutarate aminotransferase activity	cytoplasm
YDL130W-A	YDL130W-A	STF1	hom	Verified	0.171076692907106	0.432081731027312	no	2015	0.441564669637442	1469	NA	FT	NUCLEOTIDE METABOLISM	MITOCHONDRION		Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p act as stabilizing factors that enhance inhibitory action of the Inh1p protein; protein abundance increases in response to DNA replication stress	negative regulation of ATPase activity	molecular_function	mitochondrion|mitochondrial proton-transporting ATP synthase complex
YGR228W_d	YGR228W	YGR228W	hom	Dubious	0.171014715557285	0.432106097354429	no	2016	0.428646496518487	1411	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SMI1/YGR229C	Unknown	Unknown	Unknown
YBR120C	YBR120C	CBP6	hom	Verified	0.170320103525687	0.432379200958892	no	2017	0.430875470083944	1412	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex	positive regulation of mitochondrial translation|mitochondrial respiratory chain complex III assembly	ribosome binding	mitochondrion|mitochondrial ribosome
YBR203W	YBR203W	COS111	hom	Verified	0.170307637243545	0.432384102676278	no	2018	0.469090037880525	1554	NA	FT	SIGNALING	MITOCHONDRION		Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	signal transduction	molecular_function	mitochondrion
YBR248C	YBR248C	HIS7	hom	Verified	0.169951347565945	0.432524199466248	no	2019	0.426577856314495	1427	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM			Imidazole glycerol phosphate synthase (glutamine amidotransferase:cyclase), catalyzes the fifth step of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR), a purine precursor	purine nucleoside monophosphate biosynthetic process|histidine biosynthetic process	imidazoleglycerol-phosphate synthase activity	intracellular
YCL045C	YCL045C	EMC1	hom	Verified	0.169893375524484	0.432546995476068	no	2020	0.427886761572486	1395	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Member of conserved endoplasmic reticulum membrane complex; involved in efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; interacts with Gal80p; homologous to worm H17B01.4/EMC-1, fly CG2943, and human KIAA0090	protein folding in endoplasmic reticulum	molecular_function	ER membrane protein complex|endoplasmic reticulum
YAL018C_p	YAL018C	YAL018C	hom	Uncharacterized	0.169510949616671	0.43269738022129	no	2021	0.439008213334344	1437	NA					Putative protein of unknown function	biological_process	molecular_function	integral to membrane
YGL006W	YGL006W	PMC1	hom	Verified	0.169212382714412	0.432814795120847	no	2022	0.430247810276673	1417	NA	FT	ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS			Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions; prevents growth inhibition by activation of calcineurin in the presence of elevated concentrations of calcium; similar to mammalian PMCA1a	cellular calcium ion homeostasis|calcium ion transport|transmembrane transport	calcium-transporting ATPase activity	fungal-type vacuole membrane|integral to membrane
YPL001W	YPL001W	HAT1	hom	Verified	0.16787948581972	0.433339044506417	no	2023	0.441380928637026	1483	NA	FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING	NUCLEUS	HISTONE ACETYLTRANSFERASE	Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A, to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair	histone acetylation|chromatin silencing at telomere	histone acetyltransferase activity|histone binding	histone acetyltransferase complex|nucleus|cytoplasm
YDR207C	YDR207C	UME6	hom	Verified	0.167133867043168	0.433632359368647	no	2024	0.473574976712237	1570	NA	FF|FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS	NUCLEUS|CHROMOSOME		Key transcriptional regulator of early meiotic genes, binds URS1 upstream regulatory sequence, couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms complex with Ime1p, and also with Sin3p-Rpd3p	spore germination|positive regulation of transcription from RNA polymerase II promoter during meiosis|negative regulation of transcription from RNA polymerase II promoter during meiosis|lipid particle organization|nitrogen catabolite repression of transcription from RNA polymerase II promoter|pseudohyphal growth|negative regulation of transcription from RNA polymerase II promoter during mitosis|Unknown	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|repressing transcription factor binding|transcription factor binding transcription factor activity	Rpd3L-Expanded complex|Rpd3L complex
YJR098C_p	YJR098C	YJR098C	hom	Uncharacterized	0.166021366311003	0.434070067813467	no	2025	0.419163337372751	1362	NA	FT	LIPID METABOLISM	MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion|cytoplasm
YNR028W	YNR028W	CPR8	hom	Verified	0.165561347091551	0.434251083979299	no	2026	0.42061860945677	1387	NA					Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; similarity to Cpr4p suggests a potential role in the secretory pathway	biological_process	peptidyl-prolyl cis-trans isomerase activity	fungal-type vacuole
YKL008C	YKL008C	LAC1	hom	Verified	0.164764732391597	0.434564582032501	no	2027	0.433402809727145	1433	NA	FT	LIPID METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p	replicative cell aging|ceramide biosynthetic process	sphingosine N-acyltransferase activity	integral to membrane|endoplasmic reticulum
YGR247W	YGR247W	CPD1	hom	Verified	0.163896687511273	0.434906237411027	no	2028	0.43737685654524	1451	NA	FT	NUCLEOTIDE METABOLISM	GOLGI APPARATUS		Cyclic nucleotide phosphodiesterase; hydrolyzes ADP-ribose 1'', 2''-cyclic phosphate to ADP-ribose 1''-phosphate; may have a role in tRNA splicing; no detectable phenotype is conferred by null mutation or by overexpression; protein abundance increases in response to DNA replication stress	cyclic nucleotide metabolic process	2',3'-cyclic-nucleotide 3'-phosphodiesterase activity	clathrin-coated vesicle
YAL046C	YAL046C	AIM1	hom	Verified	0.163355506665516	0.435119266390133	no	2029	0.438597062011116	1433	NA					Protein involved in mitochondrial function or organization; null mutant displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	cellular_component
YAL047C	YAL047C	SPC72	hom	Verified	0.161830210550659	0.435719781016048	no	2030	0.44100559047207	1473	NA	FT	CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION	NUCLEUS|CYTOSKELETON		Component of the cytoplasmic Tub4p (gamma-tubulin) complex, binds spindle pole bodies and links them to microtubules; has roles in astral microtubule formation and stabilization	microtubule nucleation|nuclear migration along microtubule|mitotic cell cycle spindle orientation checkpoint|mitotic spindle elongation|mitotic sister chromatid segregation	structural constituent of cytoskeleton	outer plaque of spindle pole body
YLR278C_p	YLR278C	YLR278C	hom	Uncharacterized	0.161146135016069	0.435989152275583	no	2031	0.442102395604215	1467	NA	FT	TRANSCRIPTION FROM RNA POL II	NUCLEUS		Zinc-cluster protein; GFP-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; has a prion-domain like fragment that increases frequency of [URE3]; YLR278C is not an essential gene	biological_process	sequence-specific DNA binding	nucleus
YDL241W_p	YDL241W	YDL241W	hom	Uncharacterized	0.161074074096373	0.436017529733704	no	2032	0.431492101078636	1404	NA					Putative protein of unknown function; YDL241W is not an essential gene	biological_process	molecular_function	cellular_component
YMR182W-A_p	YMR182W-A	YMR182W-A	hom	Uncharacterized	0.160708897666571	0.43616134060354	no	2033	0.419867028263944	1387	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YDL224C	YDL224C	WHI4	hom	Verified	0.160332523031499	0.43630957029337	no	2034	0.404761804840974	1314	NA					Putative RNA binding protein; regulates the cell size requirement for passage through Start and commitment to cell division; WHI4 has a paralog, WHI3, that arose from the whole genome duplication	regulation of cell size	RNA binding	cytoplasm
YKL007W	YKL007W	CAP1	hom	Verified	0.160111909837651	0.436396459758877	no	2035	0.432860770784905	1408	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Alpha subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress	barbed-end actin filament capping	actin filament binding	actin filament|F-actin capping protein complex|mating projection tip|actin cortical patch
YDR158W	YDR158W	HOM2	hom	Verified	0.159952605755679	0.436459204272696	no	2036	0.462612995381521	1536	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS	NUCLEUS		Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis	methionine biosynthetic process|threonine biosynthetic process|homoserine biosynthetic process	aspartate-semialdehyde dehydrogenase activity	nucleus|plasma membrane|cytoplasm
YCR089W	YCR089W	FIG2	hom	Verified	0.159061103187692	0.436810366581221	no	2037	0.434024731584992	1407	NA	FT	CELL WALL ORG/BIOGENESIS			Cell wall adhesin, expressed specifically during mating; may be involved in maintenance of cell wall integrity during mating	filamentous growth of a population of unicellular organisms|cell morphogenesis involved in conjugation with cellular fusion|invasive growth in response to glucose limitation|cytogamy	molecular_function	fungal-type cell wall|mating projection
YDR245W	YDR245W	MNN10	hom	Verified	0.158790496727504	0.436916968162768	no	2038	0.430141271779277	1425	NA	FT	CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Subunit of a Golgi mannosyltransferase complex also containing Anp1p, Mnn9p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltransferase family	N-glycan processing|cell wall mannoprotein biosynthetic process|substituted mannan metabolic process|barrier septum assembly	alpha-1,6-mannosyltransferase activity	alpha-1,6-mannosyltransferase complex
YFL007W	YFL007W	BLM10	hom	Verified	0.158443224135999	0.43705377799088	no	2039	0.445446685096758	1462	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS	NUCLEUS		Proteasome activator; binds the core proteasome and stimulates proteasome-mediated protein degradation by inducing gate opening; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200	proteasome assembly|regulation of proteasomal protein catabolic process	proteasome binding|peptidase activator activity	proteasome core complex|proteasome complex|integral to membrane|nucleus
YMR253C_p	YMR253C	YMR253C	hom	Uncharacterized	0.157261846105033	0.437519244225149	no	2040	0.437951141699986	1471	NA					Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene	biological_process	molecular_function	integral to membrane|cytoplasm
YCR020W-B	YCR020W-B	HTL1	hom	Verified	0.157134185994725	0.437569547853158	no	2041	0.447896784904493	1482	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS	RSC COMPLEX	Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance	regulation of cell cycle|nucleosome disassembly|response to DNA damage stimulus|chromatin remodeling|transcription elongation from RNA polymerase II promoter	chromatin binding	RSC complex
YPR160W	YPR160W	GPH1	hom	Verified	0.1567742157224	0.437711397206445	no	2042	0.41668472440774	1367	NA	FT	OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY			Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway	glycogen catabolic process	glycogen phosphorylase activity	cytoplasm
YOL025W	YOL025W	LAG2	hom	Verified	0.156354524745423	0.437876790118777	no	2043	0.446840808913243	1460	NA	FT		MITOCHONDRION		Protein that negatively regulates the SCF E3-ubiquitin ligase by interacting with and preventing neddyation of the cullin subunit, Cdc53p; longevity determinant that is preferentially expressed in young cells; similar to mammalian Cand1	replicative cell aging|negative regulation of ubiquitin-protein ligase activity	molecular_function	mitochondrion
YOR067C	YOR067C	ALG8	hom	Verified	0.154929366096806	0.438438501182106	no	2044	0.449305728580887	1500	NA	FF|FT	LIPID METABOLISM|CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Glucosyl transferase, involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p	oligosaccharide-lipid intermediate biosynthetic process|protein N-linked glycosylation	dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity	integral to membrane|endoplasmic reticulum membrane
YDR465C	YDR465C	RMT2	hom	Verified	0.154862508136118	0.43846485558807	no	2045	0.456267047061447	1509	NA	FT		NUCLEUS		Arginine N5 methyltransferase; methylates ribosomal protein Rpl12 (L12) on Arg67; relative distribution to the nucleus increases upon DNA replication stress	peptidyl-arginine methylation	protein-arginine N5-methyltransferase activity	nucleus|cytoplasm
YNL022C_p	YNL022C	YNL022C	hom	Uncharacterized	0.154557886024159	0.438584936510817	no	2046	0.430130314553981	1446	NA	FT		NUCLEUS		Putative cytosine 5-methyltransferase, contains seven beta-strand methyltransferase motif similar to NOP2/YNL061W; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; predicted to be involved in ribosome biogenesis	biological_process	tRNA (cytosine-5-)-methyltransferase activity	nucleus
YLR096W	YLR096W	KIN2	hom	Verified	0.153699580326399	0.438923307850576	no	2047	0.440613830607005	1461	NA	FT	VESICLE-MEDIATED TRANSPORT|PROTEIN PHOSPHORYLATION	PLASMA MEMBRANE		Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin1p	protein autophosphorylation|exocytosis|protein phosphorylation	protein serine/threonine kinase activity|protein kinase activity	plasma membrane
YML081C-A	YML081C-A	ATP18	hom	Verified	0.153540625784521	0.438985977681036	no	2048	0.433132993701466	1426	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms	mitochondrial proton-transporting ATP synthase complex assembly|ATP synthesis coupled proton transport	hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism	mitochondrion|mitochondrial proton-transporting ATP synthase complex|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
YHR195W	YHR195W	NVJ1	hom	Verified	0.153518847643657	0.438994564106577	no	2049	0.457268224823719	1535	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS		Nuclear envelope protein, anchored to the nuclear inner membrane, that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN)	microautophagy|cellular protein localization	protein binding	nuclear envelope
YJL058C	YJL058C	BIT61	hom	Verified	0.153228170014656	0.439109171761133	no	2050	0.432379163485673	1447	NA	FT	SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION	PLASMA MEMBRANE		Subunit of TORC2 membrane-associated complex; involved in regulation of cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; BIT61 has a paralog, BIT2, that arose from the whole genome duplication	fungal-type cell wall organization|TOR signaling cascade|regulation of cell growth|establishment or maintenance of actin cytoskeleton polarity	molecular_function	TORC2 complex|plasma membrane|cytoplasm
YGR070W	YGR070W	ROM1	hom	Verified	0.153048236565787	0.439180118033606	no	2051	0.447365008576627	1492	NA	FT	SIGNALING|NUCLEOTIDE METABOLISM			GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP	small GTPase mediated signal transduction|activation of Rho GTPase activity	Rho guanyl-nucleotide exchange factor activity	intracellular
YLR285C-A_p	YLR285C-A	YLR285C-A	hom	Uncharacterized	0.152827401345202	0.439267194206995	no	2052	0.432061354159187	1421	NA					Putative protein of unknown function; identified by fungal homology and RT-PCR	biological_process	molecular_function	cellular_component
YPL199C_p	YPL199C	YPL199C	hom	Uncharacterized	0.152174493299274	0.439524655523452	no	2053	0.439708533135713	1466	NA					Putative protein of unknown function, predicted to be palmitoylated	biological_process	molecular_function	cytoplasm
YNL217W_p	YNL217W	YNL217W	hom	Uncharacterized	0.149931054698678	0.440409505266707	no	2054	0.441506335692119	1458	NA					Putative protein of unknown function; weak sequence similarity to bis (5'-nucleotidyl)-tetraphosphatases; (GFP)-fusion protein localizes to the vacuole; null mutant is highly sensitive to azaserine and resistant to sodium-O-vandate	biological_process	phosphatase activity	fungal-type vacuole
YMR007W_d	YMR007W	YMR007W	hom	Dubious	0.149776244310116	0.440470576105138	no	2055	0.42428341346699	1379	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YNL177C	YNL177C	MRPL22	hom	Verified	0.149613678816055	0.440534707763737	no	2056	0.439375636947181	1443	NA	FT	TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION	RIBOSOME	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation	structural constituent of ribosome	mitochondrion|mitochondrial large ribosomal subunit
YCL010C	YCL010C	SGF29	hom	Verified	0.14789772449972	0.441211742022181	no	2057	0.432220007416103	1407	NA	FT	PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION	NUCLEUS	HISTONE ACETYLTRANSFERASE	Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes; HAT/Core module also contains Gcn5p, Ngg1p, and Ada2p; binds methylated histone H3K4; involved in transcriptional regulation through SAGA and TBP recruitment to target promoters and H3 acetylation	histone H3-K14 acetylation|cellular protein complex localization|histone H3-K18 acetylation|cellular protein localization|histone H3-K9 acetylation|positive regulation of transcription from RNA polymerase II promoter	methylated histone residue binding|RNA polymerase II transcription factor recruiting transcription factor activity	Ada2/Gcn5/Ada3 transcription activator complex|SAGA complex
YER114C	YER114C	BOI2	hom	Verified	0.147421122044677	0.441399817342146	no	2058	0.475769802608113	1579	NA	FT	SIGNALING|CELL DIVISION	SITE OF POLARIZED GROWTH|CYTOSKELETON		Protein implicated in polar growth, functionally redundant with Boi1p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; BOI2 has a paralog, BOI1, that arose from the whole genome duplication	cytokinesis, completion of separation|establishment of cell polarity|budding cell apical bud growth|Rho protein signal transduction	phospholipid binding	site of polarized growth|cellular bud|cellular bud neck
YHR143W	YHR143W	DSE2	hom	Verified	0.146455583047747	0.441780875679765	no	2059	0.496632053021531	1691	NA	FF|FT	CELL WALL ORG/BIOGENESIS|CELL DIVISION			Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP	cytokinesis, completion of separation|pseudohyphal growth	glucosidase activity	extracellular region|fungal-type cell wall
YDL142C	YDL142C	CRD1	hom	Verified	0.146356564453278	0.441819957279164	no	2060	0.442840883444797	1463	NA	FT	LIPID METABOLISM|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS	MITOCHONDRION		Cardiolipin synthase; produces cardiolipin, which is a phospholipid of the mitochondrial inner membrane that is required for normal mitochondrial membrane potential and function; also required for normal vacuolar ion homeostasis	lipid biosynthetic process|cellular ion homeostasis|mitochondrial membrane organization	cardiolipin synthase activity	mitochondrion|integral to membrane
YGL160W	YGL160W	AIM14	hom	Verified	0.145998442252419	0.441961309076797	no	2061	0.456472062810098	1522	NA	FT	ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY			NADPH oxidase localized to the perinuclear ER; produces superoxide from NADPH; overexpression causes MCA1 dependent apoptosis; likely involved in superoxide-mediated regulation of the actin cytoskeleton; member of a conserved superfamily of NADPH oxidases (NOX enzymes); has similarity to iron/copper reductases (FRE1-8), particularly Fre8p	biological_process	oxidoreductase activity, oxidizing metal ions	integral to membrane|ribosome
YLR412C-A_p	YLR412C-A	YLR412C-A	hom	Uncharacterized	0.145816319142617	0.442033196395095	no	2062	0.446715998406419	1480	NA					Putative protein of unknown function	biological_process	molecular_function	cellular_component
YMR107W	YMR107W	SPG4	hom	Verified	0.145695274568602	0.442080975955817	no	2063	0.438495895742259	1454	NA					Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources	biological_process	molecular_function	cellular_component
YGL127C	YGL127C	SOH1	hom	Verified	0.144497249763987	0.442553914016074	no	2064	0.44795183535569	1474	NA	FT	TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION	NUCLEUS	RNA POL II, HOLOENZYME	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance; conserved with other metazoan MED31 subunits	DNA repair|meiotic gene conversion|meiotic sister chromatid segregation|transcription from RNA polymerase II promoter	molecular_function	core mediator complex|nucleus
YHR034C	YHR034C	PIH1	hom	Verified	0.144279906730071	0.442639722196161	no	2065	0.439123376999195	1450	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS	NUCLEUS		Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II	protein folding|rRNA processing|regulation of cell size|box C/D snoRNP assembly	molecular_function	R2TP complex|nucleus|small nucleolar ribonucleoprotein complex|cytoplasm
YNL294C	YNL294C	RIM21	hom	Verified	0.144021499057743	0.442741746413973	no	2066	0.446156706369494	1466	NA	FF|FT	ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS	PLASMA MEMBRANE		pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH	fungal-type cell wall biogenesis|ascospore formation|invasive growth in response to glucose limitation	molecular_function	integral to membrane
YDR199W_d	YDR199W	YDR199W	hom	Dubious	0.142672186687747	0.443274541885563	no	2067	0.463249099620136	1534	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity	Unknown	Unknown	Unknown
YDR132C	YDR132C	YDR132C	hom	Verified	0.141258678501269	0.443832796000567	no	2068	0.452421420683454	1488	NA	FT	ION HOMEOSTASIS|ION HOMEOSTASIS	NUCLEUS|PLASMA MEMBRANE		Protein of unknown function; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; YDR132C has a paralog, YLR108C, that arose from the whole genome duplication	biological_process	molecular_function	nucleus|cytoplasm
YHR011W	YHR011W	DIA4	hom	Verified	0.14110422337706	0.443893803631934	no	2069	0.44118811722939	1477	NA	FT	KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Probable mitochondrial seryl-tRNA synthetase, mutant displays increased invasive and pseudohyphal growth	pseudohyphal growth|invasive growth in response to glucose limitation|mitochondrial seryl-tRNA aminoacylation	serine-tRNA ligase activity	mitochondrion|cytoplasm
YIL077C_p	YIL077C	YIL077C	hom	Uncharacterized	0.141068090316472	0.443908075881569	no	2070	0.453604352628209	1513	NA	FT		MITOCHONDRION		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)	biological_process	molecular_function	mitochondrion
YLR408C_p	YLR408C	BLS1	hom	Uncharacterized	0.140910686134451	0.443970250034584	no	2071	0.430377866953747	1411	NA					Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene	biological_process	molecular_function	endosome|BLOC-1 complex
YGR234W	YGR234W	YHB1	hom	Verified	0.140748617751262	0.444034267973197	no	2072	0.440272215057087	1437	NA	FT	OXIDATION-REDUCTION PROCESS	MITOCHONDRION		Nitric oxide oxidoreductase; flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress	response to stress	nitric oxide reductase activity	cytosol|mitochondrion|mitochondrial matrix|cytoplasm
YLR111W_d	YLR111W	YLR111W	hom	Dubious	0.140654739938095	0.444071350914548	no	2073	0.454328096174945	1512	NA	FF				Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data	Unknown	Unknown	Unknown
YIL128W	YIL128W	MET18	hom	Verified	0.140558786310379	0.444109254335312	no	2074	0.377319212830132	2096	NA	FT	TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|RESPONSE TO DNA DAMAGE	NUCLEUS		Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Cia2p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human MMS19	methionine metabolic process|nucleotide-excision repair|transcription from RNA polymerase II promoter	molecular_function	cytoplasm
YIL160C	YIL160C	POT1	hom	Verified	0.14010043595934	0.444290318072532	no	2075	0.438066850972414	1446	NA	FT	KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS			3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids	fatty acid beta-oxidation	mRNA binding|acetyl-CoA C-acyltransferase activity	peroxisomal matrix|peroxisome
YKL090W	YKL090W	CUE2	hom	Verified	0.139690655993387	0.44445220472679	no	2076	0.437822713797662	1449	NA					Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination	biological_process	ubiquitin binding	cellular_component
YER026C	YER026C	CHO1	hom	Verified	0.139527321038891	0.44451673401224	no	2077	0.454603332513186	1499	NA	FT	LIPID METABOLISM	ENDOPLASMIC RETICULUM|MITOCHONDRION		Phosphatidylserine synthase, functions in phospholipid biosynthesis; catalyzes the reaction CDP-diaclyglycerol + L-serine = CMP + L-1-phosphatidylserine, transcriptionally repressed by myo-inositol and choline	phosphatidylserine biosynthetic process	CDP-diacylglycerol-serine O-phosphatidyltransferase activity	mitochondrial outer membrane|integral to membrane|endoplasmic reticulum
YDL073W_p	YDL073W	YDL073W	hom	Uncharacterized	0.139398085897533	0.444567792412952	no	2078	0.463566533990667	1553	NA					Putative protein of unknown function; YDL073W is not an essential gene	biological_process	molecular_function	cellular_component
YJL043W_p	YJL043W	YJL043W	hom	Uncharacterized	0.138827833715831	0.444793099416579	no	2079	0.411648472986217	1388	NA	FT		MITOCHONDRION		Putative protein of unknown function; YJL043W is a non-essential gene	biological_process	molecular_function	mitochondrion|cytoplasm
YLL028W	YLL028W	TPO1	hom	Verified	0.13841903006827	0.444954628981993	no	2080	0.415306391054542	1348	NA	FT		PLASMA MEMBRANE		Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane	spermidine transport|putrescine transport|spermine transport	spermidine transmembrane transporter activity|spermine transmembrane transporter activity	fungal-type vacuole membrane|integral to membrane|cellular bud membrane|plasma membrane
YNL098C	YNL098C	RAS2	hom	Verified	0.137544931550826	0.445300039981718	no	2081	0.485613099226305	1629	NA	FT	PROTEIN LOCALIZATION|SIGNALING|NUCLEOTIDE METABOLISM|RESPONSE TO NUTRIENT LEVELS	PLASMA MEMBRANE		GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes	pseudohyphal growth|ascospore formation|activation of adenylate cyclase activity|regulation of protein localization|replicative cell aging|positive regulation of transcription by galactose|Ras protein signal transduction	GTP binding|GTPase activity	plasma membrane
YOR239W	YOR239W	ABP140	hom	Verified	0.137062108482338	0.445490851399276	no	2082	0.446954552579546	1485	NA	FT	RNA PROCESSING|CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH|CYTOSKELETON		AdoMet-dependent tRNA methyltransferase and actin binding protein; C-terminal domain is responsible for 3-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA-Thr and tRNA-Ser and contains an S-adenosylmethionine (AdoMet) binding motif; N-terminal actin binding sequence interacts with actin filaments and localizes to actin patches and cables; N- and C-terminal domains are encoded in separate ORFs that are translated into one protein via a +1 frameshift	actin filament bundle assembly|tRNA methylation	tRNA (cytosine-3-)-methyltransferase activity|actin filament binding|protein binding, bridging	actin filament|actin filament bundle|mating projection tip|actin cortical patch
YDL190C	YDL190C	UFD2	hom	Verified	0.136470805281829	0.445724551304526	no	2083	0.448935688352225	1491	NA	FT	PROTEOLYSIS	NUCLEUS		Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3	ER-associated protein catabolic process|protein ubiquitination|ubiquitin-dependent protein catabolic process|response to stress	ubiquitin-ubiquitin ligase activity	nucleus|cytoplasm
YBR085W	YBR085W	AAC3	hom	Verified	0.135277132110798	0.446196382399172	no	2084	0.443036762399251	1483	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Aac1p; has roles in maintenance of viability and in respiration; AAC3 has a paralog, PET9, that arose from the whole genome duplication	heme biosynthetic process|heme transport|anaerobic respiration|transmembrane transport	ATP:ADP antiporter activity	mitochondrion|integral to membrane|mitochondrial inner membrane
YDR078C	YDR078C	SHU2	hom	Verified	0.135051542303221	0.446285561356299	no	2085	0.451777079796738	1498	NA	FT	RESPONSE TO DNA DAMAGE	NUCLEUS		Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function	recombinational repair|maintenance of rDNA|error-free translesion synthesis	molecular_function	Shu complex
YBL067C	YBL067C	UBP13	hom	Verified	0.134754017443199	0.446403181447893	no	2086	0.454163969136684	1494	NA	FT	PROTEOLYSIS			Putative ubiquitin-specific protease that cleaves Ub-protein fusions; UBP13 has a paralog, UBP9, that arose from the whole genome duplication	biological_process	ubiquitin-specific protease activity	cellular_component
YJR147W	YJR147W	HMS2	hom	Verified	0.134190861750803	0.446625825911575	no	2087	0.447582252830139	1471	NA	FT		NUCLEUS		Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant; HMS2 has a paralog, SKN7, that arose from the whole genome duplication	pseudohyphal growth	molecular_function	nucleus|cytoplasm
YGR135W	YGR135W	PRE9	hom	Verified	0.133508891448712	0.446895466431609	no	2088	0.450585048236618	1454	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS	ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION		Alpha 3 subunit of the 20S proteasome, the only nonessential 20S subunit; may be replaced by the alpha 4 subunit (Pre6p) under stress conditions to create a more active proteasomal isoform	proteasomal ubiquitin-dependent protein catabolic process|proteasome core complex assembly|proteasomal ubiquitin-independent protein catabolic process	molecular_function	mitochondrion|proteasome core complex, alpha-subunit complex|proteasome storage granule|nucleus|nuclear outer membrane-endoplasmic reticulum membrane network
YAL037W_p	YAL037W	YAL037W	hom	Uncharacterized	0.132952635610433	0.447115419580736	no	2089	0.4541061883053	1520	NA					Putative protein of unknown function; YAL037W has a paralog, YOR342C, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component
YFR011C	YFR011C	AIM13	hom	Verified	0.132802556409918	0.447174766273564	no	2090	0.442232611926316	1450	NA	FT	MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION	MITOCHONDRION		Mitochondrial protein peripheral to the inner membrane; component of the mitochondrial inner membrane organizing system (MINOS, MitOS, or MICOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture	cristae formation	molecular_function	mitochondrion|extrinsic to mitochondrial inner membrane|mitochondrial crista junction|cytoplasm|mitochondrial intermembrane space
YOL038C-A_p	YOL038C-A	YOL038C-A	hom	Uncharacterized	0.131803831887799	0.447569727794719	no	2091	0.434517565106988	1424	NA					Putative protein of unknown function; identified by SAGE analysis	biological_process	molecular_function	cellular_component
YLR364W	YLR364W	GRX8	hom	Verified	0.131123704069715	0.447838724958233	no	2092	0.424819204190076	1380	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY			Glutaredoxin that employs a dithiol mechanism of catalysis; monomeric; activity is low and null mutation does not affect sensitivity to oxidative stress; GFP-fusion protein localizes to the cytoplasm; expression strongly induced by arsenic	biological_process	glutathione-disulfide reductase activity	cytoplasm
YMR144W_p	YMR144W	YMR144W	hom	Uncharacterized	0.130385558848337	0.448130695712266	no	2093	0.445922183669858	1459	NA	FT		NUCLEUS		Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene	biological_process	molecular_function	nucleus
YLL014W	YLL014W	EMC6	hom	Verified	0.130164519669797	0.448218132458883	no	2094	0.479341666429837	1591	NA	FT		ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM		Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93	protein folding in endoplasmic reticulum	molecular_function	ER membrane protein complex|integral to membrane|endoplasmic reticulum
YDR031W	YDR031W	MIC14	hom	Verified	0.130080864923313	0.448251224528895	no	2095	0.440029114655591	1435	NA	FT	OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY	NUCLEUS|MITOCHONDRION		Mitochondrial intermembrane space protein of unknown function; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress	aerobic respiration	molecular_function	nucleus|mitochondrial intermembrane space|cytoplasm
YLR334C_d	YLR334C	YLR334C	hom	Dubious	0.12887805398908	0.448727071105413	no	2096	0.432013306000391	1434	NA					Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps a stand-alone long terminal repeat sequence whose presence indicates a retrotransposition event occurred here	Unknown	Unknown	Unknown
YDR420W	YDR420W	HKR1	hom	Verified	0.128649862267465	0.44881735486061	no	2097	0.458130940164171	1524	NA	FT	CELL CYCLE|SIGNALING|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM	SITE OF POLARIZED GROWTH|PLASMA MEMBRANE		Mucin family member that functions as an osmosensor in the Sho1p-mediated HOG pathway with Msb2p; proposed to be a negative regulator of filamentous growth; mutant displays defects in beta-1,3 glucan synthesis and bud site selection	(1->3)-beta-D-glucan biosynthetic process|fungal-type cell wall organization|osmosensory signaling pathway via Sho1 osmosensor|hyperosmotic response|cellular bud site selection	osmosensor activity	site of polarized growth|plasma membrane
YCR030C	YCR030C	SYP1	hom	Verified	0.128581955708868	0.448844222513345	no	2098	0.432948808318596	1397	NA	FT	CYTOSKELETON ORGANIZATION	SITE OF POLARIZED GROWTH		Protein of unknown function that is involved in endocytic site formation; may regulate assembly and disassembly of the septin ring; colocalizes and interacts with septin subunits; potential role in actin cytoskeletal organization	septin cytoskeleton organization|actin cortical patch assembly	molecular_function	mating projection base|mating projection tip|cellular bud neck|cellular bud tip
YGL038C	YGL038C	OCH1	hom	Verified	0.128027242320773	0.449063707093818	no	2099	0.4520215956975	1862	NA	FT	CARBOHYDRATE METABOLISM	ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS		Mannosyltransferase of the cis-Golgi apparatus, initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins	protein N-linked glycosylation	alpha-1,6-mannosyltransferase activity|transferase activity, transferring glycosyl groups	Golgi cis cisterna
YPL165C	YPL165C	SET6	hom	Verified	0.127977674641197	0.44908332039861	no	2100	0.445259521207029	1453	NA					SET domain protein of unknown function; deletion heterozygote is sensitive to compounds that target ergosterol biosynthesis, may be involved in compound availability	biological_process	molecular_function	cellular_component
YGL133W	YGL133W	ITC1	hom	Verified	0.127751049022448	0.449172994877879	no	2101	0.437467526431778	1437	NA	FT	TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING	NUCLEUS		Subunit of the ATP-dependent Isw2p-Itc1p chromatin remodeling complex, required for repression of a-specific genes, repression of early meiotic genes during mitotic growth, and repression of INO1; similar to mammalian Acf1p, the regulatory subunit of the mammalian ATP-utilizing chromatin assembly and modifying factor (ACF) complex	negative regulation of transcription from RNA polymerase II promoter by pheromones|chromatin remodeling|chromatin silencing at telomere	molecular_function	chromatin accessibility complex
YOR327C	YOR327C	SNC2	hom	Verified	0.127296450072901	0.449352884941325	no	2102	0.430134811614008	1404	NA	FT	VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION	ENDOMEMBRANE SYSTEM|GOLGI APPARATUS		Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC2 has a paralog, SNC1, that arose from the whole genome duplication	endocytosis|exocytosis|Golgi to plasma membrane transport|vesicle fusion	SNAP receptor activity	SNARE complex|trans-Golgi network|endosome|transport vesicle membrane
YOL091W	YOL091W	SPO21	hom	Verified	0.126180601310721	0.449794483267592	no	2103	0.435591063570789	1415	NA	FT	CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION	CYTOSKELETON		Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation	ascospore wall assembly|meiosis	structural molecule activity	spindle pole body
YNL016W	YNL016W	PUB1	hom	Verified	0.125899316618974	0.449905811815695	no	2104	0.422632431132669	1408	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS	NUCLEUS		Poly (A)+ RNA-binding protein; abundant mRNP-component protein that binds mRNA and is required for stability of many mRNAs; component of glucose deprivation induced stress granules, involved in P-body-dependent granule assembly; protein abundance increases in response to DNA replication stress	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|stress granule assembly|regulation of mRNA stability	mRNA binding|poly(U) RNA binding	nucleus|cytoplasmic stress granule|cytoplasm
YHR092C	YHR092C	HXT4	hom	Verified	0.125742962565371	0.449967696269392	no	2105	0.407273217942765	1358	NA	FT		PLASMA MEMBRANE		High-affinity glucose transporter; member of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose; HXT4 has a paralog, HXT7, that arose from the whole genome duplication	hexose transport	pentose transmembrane transporter activity|mannose transmembrane transporter activity|glucose transmembrane transporter activity|fructose transmembrane transporter activity	integral to membrane|plasma membrane
YDR055W	YDR055W	PST1	hom	Verified	0.125183412551247	0.450189174402498	no	2106	0.441628137226138	1438	NA	FT	CELL WALL ORG/BIOGENESIS	PLASMA MEMBRANE		Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1	fungal-type cell wall organization	molecular_function	fungal-type cell wall|plasma membrane
YGL163C	YGL163C	RAD54	hom	Verified	0.124326471283179	0.450528394422412	no	2107	0.491620612006	1707	NA	FF|FT	CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE	NUCLEUS		DNA-dependent ATPase that stimulates strand exchange; modifies the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family; forms nuclear foci upon DNA replication stress	positive regulation of endodeoxyribonuclease activity|DNA geometric change|heteroduplex formation|telomere maintenance via recombination|double-strand break repair via synthesis-dependent strand annealing|chromatin remodeling|double-strand break repair via single-strand annealing	DNA-dependent ATPase activity|DNA translocase activity	nucleus
YPR002W	YPR002W	PDH1	hom	Verified	0.123672492444646	0.450787296136514	no	2108	0.438913273666156	1457	NA	FT	KETONE METABOLISM	MITOCHONDRION		Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate	propionate metabolic process|propionate catabolic process, 2-methylcitrate cycle	2-methylcitrate dehydratase activity	mitochondrial outer membrane|mitochondrion|cytoplasm
YOR198C	YOR198C	BFR1	hom	Verified	0.121925024537765	0.45147919838257	no	2109	0.481770977320784	1612	NA	FT	CELL CYCLE	ENDOMEMBRANE SYSTEM		Component of mRNP complexes associated with polyribosomes; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity	meiosis|mRNA metabolic process|regulation of mitosis	RNA binding	ribonucleoprotein complex|polysome|nuclear outer membrane-endoplasmic reticulum membrane network
YML017W	YML017W	PSP2	hom	Verified	0.121475941054517	0.451657034912425	no	2110	0.461517175398613	1517	NA					Asn rich cytoplasmic protein that contains RGG motifs; high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha); possible role in mitochondrial mRNA splicing	biological_process	molecular_function	cytoplasm
YOR304C-A_p	YOR304C-A	YOR304C-A	hom	Uncharacterized	0.121296259080118	0.45172819148184	no	2111	0.45306360283788	1479	NA	FT		SITE OF POLARIZED GROWTH		Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck	biological_process	molecular_function	cellular bud|mating projection tip|cellular bud neck|cytoplasm
YOL085C_d	YOL085C	YOL085C	hom	Dubious	0.120369873698556	0.45209507758103	no	2112	0.45486252349852	1517	NA					Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A	Unknown	Unknown	Unknown
YIL149C	YIL149C	MLP2	hom	Verified	0.119547364248159	0.452420858906751	no	2113	0.445423688454885	1463	NA	FT	PROTEIN LOCALIZATION|CELL CYCLE|CYTOSKELETON ORGANIZATION|RNA LOCALIZATION	ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION|CYTOSKELETON		Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved in the Tel1p pathway that controls telomere length	poly(A)+ mRNA export from nucleus|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|regulation of transcription, DNA-dependent|telomere tethering at nuclear periphery|spindle pole body organization|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	ribonucleoprotein complex binding	nucleoplasm|nuclear envelope|mitochondrion|ribonucleoprotein complex|integral to membrane|spindle pole body
YKL087C	YKL087C	CYT2	hom	Verified	0.119455839636049	0.452457112158146	no	2114	0.452555410654217	1497	NA	FT	PROTEIN COMPLEX ORG/BIOGENESIS	MITOCHONDRION		Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1	cytochrome c-heme linkage	holocytochrome-c synthase activity	mitochondrion|mitochondrial intermembrane space
YGR193C	YGR193C	PDX1	hom	Verified	0.118815524115774	0.452710754672003	no	2115	0.43254963013517	1425	NA	FT	KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM	MITOCHONDRION		Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core	acetyl-CoA biosynthetic process from pyruvate	structural molecule activity	mitochondrion|mitochondrial pyruvate dehydrogenase complex
YOR226C	YOR226C	ISU2	hom	Verified	0.118590564009541	0.452799870711871	no	2116	0.449532582699936	1487	NA	FT	RNA PROCESSING|ION HOMEOSTASIS|ION HOMEOSTASIS|COFACTOR METABOLISM	MITOCHONDRION		Protein required for synthesis of iron-sulfur proteins; localized to the mitochondrial matrix; performs a scaffolding function in mitochondria during Fe/S cluster assembly; involved in Fe-S cluster assembly for both mitochondrial and cytosolic proteins; isu1 isu2 double mutant is inviable; protein abundance increases in response to DNA replication stress; evolutionarily conserved	cellular iron ion homeostasis|iron-sulfur cluster assembly|tRNA wobble uridine modification	molecular_function	mitochondrial matrix
YPR185W	YPR185W	ATG13	hom	Verified	0.11806932900862	0.453006362669389	no	2117	0.453975720621625	1504	NA	FT	PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS			Regulatory subunit of the Atg1p signaling complex; stimulates Atg1p kinase activity; required for vesicle formation during autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; involved in Atg9p, Atg23p, and Atg27p cycling	piecemeal microautophagy of nucleus|mitochondrion degradation|macroautophagy|activation of protein kinase activity|CVT pathway	protein kinase regulator activity	Atg1p signaling complex|extrinsic to membrane
YGL051W	YGL051W	MST27	hom	Verified	0.117973441157485	0.453044350894035	no	2118	0.450583410109741	1481	NA	FT	PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT	ENDOMEMB