strainid orf gene zyg qualifier SGTC_2299|7976368.score SGTC_2299|7976368.expt.zyg.pval SGTC_2299|7976368.expt.zyg.significant SGTC_2299|7976368.expt.zyg.rank strain.pval strain.rank clearance Fclass Fterms.BP Fterms.CC Fterms.complex description GO_process GO_function GO_component
YER090W YER090W TRP2 hom Verified 11.1514567831264 3.52217581435162e-29 yes 1 1.97197446006872e-07 54 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p tryptophan biosynthetic process anthranilate synthase activity anthranilate synthase complex|cytoplasm
YKL211C YKL211C TRP3 hom Verified 10.4018302501342 1.21608032490481e-25 yes 2 3.19901663798102e-06 102 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p tryptophan biosynthetic process indole-3-glycerol-phosphate synthase activity|anthranilate synthase activity anthranilate synthase complex|cytoplasm
YDR354W YDR354W TRP4 hom Verified 9.74168450907515 1.00103825508437e-22 yes 3 2.15790553890002e-06 92 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis tryptophan biosynthetic process anthranilate phosphoribosyltransferase activity nucleus|cytoplasm
YDR253C YDR253C MET32 hom Verified 7.56359961901739 1.96032646276811e-14 yes 4 3.84746979341588e-13 6 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CELL CYCLE|AMINO ACID METABOLISM NUCLEUS Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; MET32 has a paralog, MET31, that arose from the whole genome duplication regulation of mitotic cell cycle|regulation of sulfur amino acid metabolic process|regulation of transcription from RNA polymerase II promoter core promoter proximal region sequence-specific DNA binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity nucleus|cytoplasm
YER167W YER167W BCK2 hom Verified 7.51416134074795 2.86384563464428e-14 yes 5 7.51896006772251e-13 1 NA FT CELL CYCLE NUCLEUS Protein rich in serine and threonine residues involved in protein kinase C signaling pathway, which controls cell integrity; overproduction suppresses pkc1 mutations regulation of cell cycle|positive regulation of gene expression|G1/S transition of mitotic cell cycle molecular_function nucleus|cytoplasm
YMR202W YMR202W ERG2 hom Verified 6.05538974570714 7.00390453387594e-10 yes 6 7.89066193411154e-05 186 NA FF|FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis ergosterol biosynthetic process C-8 sterol isomerase activity endoplasmic reticulum
YPL258C YPL258C THI21 hom Verified 6.05266987123693 7.12323189540708e-10 yes 7 1.41919051783659e-10 5 NA Hydroxymethylpyrimidine (HMP) and HMP-phosphate kinase; involved in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p thiamine biosynthetic process phosphomethylpyrimidine kinase activity|hydroxymethylpyrimidine kinase activity cellular_component
YPL156C YPL156C PRM4 hom Verified 6.01172613459746 9.17791156351542e-10 yes 8 6.36261302739267e-12 3 NA Pheromone-regulated protein proposed to be involved in mating; predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift biological_process molecular_function integral to membrane
YPL069C YPL069C BTS1 hom Verified 5.92634880978617 1.54872147983706e-09 yes 9 0.000409336214438406 76 NA FF|FT PROTEIN LOCALIZATION|LIPID METABOLISM MITOCHONDRION Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic terpenoid biosynthetic process farnesyltranstransferase activity mitochondrion
YDL020C YDL020C RPN4 hom Verified 5.8245248157044 2.863766377097e-09 yes 10 0.00340644631448762 215 NA FF|FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|PROTEOLYSIS NUCLEUS Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance|regulation of DNA repair|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YNL093W YNL093W YPT53 hom Verified 5.65845778552851 7.6369636957491e-09 yes 11 2.58796568811166e-08 7 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|VACUOLAR TRANSPORT PLASMA MEMBRANE Rab family GTPase; similar to Ypt51p and Ypt52p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; YPT53 has a paralog, VPS21, that arose from the whole genome duplication endocytosis|protein targeting to vacuole GTPase activity late endosome
YER039C-A_p YER039C-A YER039C-A hom Uncharacterized 5.13617590066792 1.4019261952689e-07 yes 12 7.53905884563389e-08 1 NA Putative protein of unknown function; YER039C-A is not an essential gene biological_process molecular_function integral to membrane
YBL091C YBL091C MAP2 hom Verified 5.12994484632281 1.44913541849742e-07 yes 13 9.58759111154187e-08 3 NA FT PROTEOLYSIS Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map1p protein initiator methionine removal involved in protein maturation metalloaminopeptidase activity cytoplasm
YDR110W YDR110W FOB1 hom Verified 4.98791559265502 3.05171112447038e-07 yes 14 9.76036242895569e-08 4 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CHROMATIN ORGANIZATION|CHROMOSOME SEGREGATION|GENE SILENCING NUCLEUS|CHROMOSOME Nucleolar protein that binds the rDNA replication fork barrier (RFB) site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to RFB and rDNA repeat segregation; related to retroviral integrases extrachromosomal circular DNA accumulation involved in cell aging|negative regulation of DNA replication|rDNA condensation|chromatin silencing at rDNA|replicative cell aging|protein localization to nucleolar rDNA repeats|DNA recombination rDNA spacer replication fork barrier binding nucleolus|rDNA heterochromatin
YOR298C-A YOR298C-A MBF1 hom Verified 4.94907814441722 3.72829034658344e-07 yes 15 6.42390775464908e-09 2 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS|MITOCHONDRION Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress positive regulation of transcription from RNA polymerase II promoter transcription coactivator activity mitochondrion|nucleus
YGR250C YGR250C YGR250C hom Verified 4.92007877822459 4.32546929648519e-07 yes 16 7.60831808138072e-07 3 NA Putative RNA binding protein; localizes to stress granules induced by glucose deprivation; interacts with Rbg1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress biological_process RNA binding cytoplasmic stress granule|cytoplasm
YBR006W YBR006W UGA2 hom Verified 4.57820198457748 2.34494862872916e-06 yes 17 1.86108966998137e-06 25 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm cellular response to oxidative stress|gamma-aminobutyric acid catabolic process|glutamate decarboxylation to succinate succinate-semialdehyde dehydrogenase [NAD(P)+] activity cytoplasm
YJR031C YJR031C GEA1 hom Verified 4.51153391096497 3.21802455377914e-06 yes 18 1.07159358235579e-06 4 NA FT VESICLE-MEDIATED TRANSPORT|SIGNALING|CYTOSKELETON ORGANIZATION|RESPONSE TO NUTRIENT LEVELS GOLGI APPARATUS Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA1 has a paralog, GEA2, that arose from the whole genome duplication retrograde vesicle-mediated transport, Golgi to ER|ER to Golgi vesicle-mediated transport|macroautophagy|intra-Golgi vesicle-mediated transport|actin cytoskeleton organization ARF guanyl-nucleotide exchange factor activity integral to membrane|Golgi cis cisterna|Golgi-associated vesicle|extrinsic to membrane
YKR011C YKR011C YKR011C hom Verified 4.50680447417601 3.29056126258077e-06 yes 19 9.09444971791763e-07 11 NA FT NUCLEUS Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus
YLR146C YLR146C SPE4 hom Verified 4.36126995357599 6.46548530369136e-06 yes 20 1.93434774723705e-06 5 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM Spermine synthase, required for the biosynthesis of spermine and also involved in biosynthesis of pantothenic acid pantothenate biosynthetic process|spermine biosynthetic process spermine synthase activity cytoplasm
YFR021W YFR021W ATG18 hom Verified 4.33075459886758 7.42996093889337e-06 yes 21 1.24724742780775e-05 8 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION|VACUOLAR PROTEIN PROCESSING Phosphoinositide binding protein; required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein; relocalizes from vacuole to cytoplasm upon DNA replication stress; has 4 mammalian homologs WIPI1, WIPI2, WIPI3 and WIPI4/WDR45; mutations in human WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood piecemeal microautophagy of nucleus|peroxisome degradation|vacuolar protein processing|macroautophagy|late endosome to vacuole transport|CVT pathway ubiquitin binding|phosphatidylinositol binding cytosol|endosome|fungal-type vacuole membrane|PAS complex|pre-autophagosomal structure
YBR040W YBR040W FIG1 hom Verified 4.21533899840705 1.24701633682576e-05 yes 22 4.26470999310034e-06 7 NA FT SITE OF POLARIZED GROWTH Integral membrane protein required for efficient mating; may participate in or regulate the low affinity Ca2+ influx system, which affects intracellular signaling and cell-cell fusion during mating cell morphogenesis involved in conjugation with cellular fusion|cytogamy molecular_function fungal-type cell wall|integral to membrane|mating projection tip
YBR064W_d YBR064W YBR064W hom Dubious 4.15814333844648 1.60422343761088e-05 yes 23 4.98560961502886e-06 8 NA Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YBR063C Unknown Unknown Unknown
YPL032C YPL032C SVL3 hom Verified 4.13555113833913 1.77051872631298e-05 yes 24 0.000113808113968971 13 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS SITE OF POLARIZED GROWTH Protein of unknown function; mutant phenotype suggests a potential role in vacuolar function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; relocalizes from bud neck to cytoplasm upon DNA replication stress endocytosis molecular_function cellular bud|cellular bud neck|cytoplasm
YBR106W YBR106W PHO88 hom Verified 4.13115305171539 1.80474076055587e-05 yes 25 0.00118509009849195 114 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations phosphate ion transport molecular_function mitochondrion|membrane
YNL279W YNL279W PRM1 hom Verified 4.11049559408411 1.97405407167393e-05 yes 26 1.87938775535119e-05 13 NA FT MEMBRANE ORGANIZATION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p plasma membrane fusion involved in cytogamy|response to pheromone molecular_function integral to membrane|mating projection tip
YDL226C YDL226C GCS1 hom Verified 4.10730711040845 2.00149413101957e-05 yes 27 0.000290138656667621 176 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|SIGNALING|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION MITOCHONDRION|GOLGI APPARATUS|CYTOSKELETON ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p retrograde vesicle-mediated transport, Golgi to ER|Golgi to plasma membrane protein transport|actin filament reorganization involved in cell cycle|ER to Golgi vesicle-mediated transport actin binding|ARF GTPase activator activity|GTPase activator activity endosome|trans-Golgi network|endoplasmic reticulum-Golgi intermediate compartment|cytoskeleton
YCR043C_p YCR043C YCR043C hom Uncharacterized 4.08519030814214 2.20203526142593e-05 yes 28 6.17791535695274e-05 18 NA FT GOLGI APPARATUS|SITE OF POLARIZED GROWTH Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene biological_process molecular_function Golgi apparatus|mating projection tip
YHR059W YHR059W FYV4 hom Verified 4.08070011982548 2.24501264131049e-05 yes 29 1.51639922610723e-05 12 NA FT MITOCHONDRION Protein of unknown function, required for survival upon exposure to K1 killer toxin biological_process molecular_function mitochondrion
YDR337W YDR337W MRPS28 hom Verified 4.00588677338273 3.08926212478106e-05 yes 30 0.000176093375475517 31 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit mitochondrial translation structural constituent of ribosome|RNA binding mitochondrion|mitochondrial small ribosomal subunit
YKR097W YKR097W PCK1 hom Verified 3.90639456946216 4.68417455370563e-05 yes 31 4.18708388466563e-05 28 NA FT CARBOHYDRATE METABOLISM Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol gluconeogenesis phosphoenolpyruvate carboxykinase (ATP) activity cytosol
YLL060C YLL060C GTT2 hom Verified 3.89183034409792 4.97454040548454e-05 yes 32 4.82985220373759e-05 12 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p; protein abundance increases in response to DNA replication stress glutathione metabolic process glutathione transferase activity mitochondrion
YLR454W_p YLR454W FMP27 hom Uncharacterized 3.88739487505446 5.06629235704157e-05 yes 33 2.4779696792046e-05 28 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YAL044C YAL044C GCV3 hom Verified 3.86765508258017 5.49434720205401e-05 yes 34 0.000348877234562481 34 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5,10-methylene-THF glycine catabolic process|one-carbon metabolic process|protein lipoylation glycine dehydrogenase (decarboxylating) activity mitochondrion|glycine cleavage complex
YDR035W YDR035W ARO3 hom Verified 3.85612213506435 5.75999733940523e-05 yes 35 0.00370968456646914 143 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS|MITOCHONDRION 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan aromatic amino acid family biosynthetic process 3-deoxy-7-phosphoheptulonate synthase activity mitochondrion|nucleus|cytoplasm
YDR127W YDR127W ARO1 hom Verified 3.83097465978355 6.38183257886714e-05 yes 36 0.010204414495785 317 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids aromatic amino acid family biosynthetic process shikimate kinase activity|shikimate 3-dehydrogenase (NADP+) activity|3-phosphoshikimate 1-carboxyvinyltransferase activity|3-dehydroquinate dehydratase activity|3-dehydroquinate synthase activity cytoplasm
YGL058W YGL058W RAD6 hom Verified 3.82162057215492 6.62887828533751e-05 yes 37 7.36786952402835e-05 8 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEOLYSIS|GENE SILENCING NUCLEUS|CHROMOSOME Ubiquitin-conjugating enzyme (E2), involved in postreplication repair (as a heterodimer with Rad18p), DSBR and checkpoint control (as a heterodimer with Bre1p), ubiquitin-mediated N-end rule protein degradation (as a heterodimer with Ubr1p protein ubiquitination involved in ubiquitin-dependent protein catabolic process|histone monoubiquitination|protein monoubiquitination|error-free translesion synthesis|error-prone translesion synthesis|transcription from RNA polymerase II promoter|mitotic cell cycle G1/S transition DNA damage checkpoint|regulation of dipeptide transport|meiotic DNA double-strand break formation|ubiquitin-dependent protein catabolic process via the N-end rule pathway|double-strand break repair via homologous recombination|protein polyubiquitination|error-free postreplication DNA repair|chromatin silencing at telomere ubiquitin-protein ligase activity nuclear chromatin|proteasome complex|nucleus|cytoplasm
YDL075W YDL075W RPL31A hom Verified 3.78339969409381 7.73503428556345e-05 yes 38 0.000458324909468922 22 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L31A; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31A has a paralog, RPL31B, that arose from the whole genome duplication cytoplasmic translation|regulation of translational fidelity structural constituent of ribosome cytosolic large ribosomal subunit
YKL212W YKL212W SAC1 hom Verified 3.70404579804189 0.000106093962046807 yes 39 0.00652240897501173 196 NA FF|FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS Phosphatidylinositol phosphate (PtdInsP) phosphatase; involved in hydrolysis of PtdIns[4]P in the early and medial Golgi; regulated by interaction with Vps74p; ER localized transmembrane protein which cycles through the Golgi; involved in protein trafficking and processing, secretion, and cell wall maintenance; regulates sphingolipid biosynthesis through the modulation of PtdIns(4)P metabolism phosphatidylinositol dephosphorylation phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity|phosphatidylinositol-3-phosphatase activity|phosphatidylinositol-4-phosphate phosphatase activity mitochondrial outer membrane|integral to endoplasmic reticulum membrane|mitochondrion|SPOTS complex|integral to Golgi membrane
YDR092W YDR092W UBC13 hom Verified 3.62082749195049 0.000146831138375094 yes 40 3.60334183937379e-05 22 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE NUCLEUS Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus postreplication repair|protein monoubiquitination|protein polyubiquitination|free ubiquitin chain polymerization ubiquitin-protein ligase activity ubiquitin conjugating enzyme complex|nucleus|cytoplasm
YJR120W YJR120W YJR120W hom Verified 3.59959259594634 0.00015935806437894 yes 41 0.000139702972132562 13 NA FT OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p cellular respiration|sterol transport|mitochondrion organization molecular_function cellular_component
YLR187W YLR187W SKG3 hom Verified 3.59739033476063 0.00016071297215705 yes 42 0.000136959999613898 17 NA FT SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate; similar to Skg4p; relocalizes from bud neck to cytoplasm upon DNA replication stress; SKG3 has a paralog, CAF120, that arose from the whole genome duplication biological_process molecular_function cellular bud|cellular bud neck|cytoplasm
YNL148C YNL148C ALF1 hom Verified 3.58842433392163 0.00016634125738281 yes 43 0.00193369648370917 111 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS NUCLEUS|CYTOSKELETON Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance protein folding|post-chaperonin tubulin folding pathway microtubule binding|alpha-tubulin binding nucleus|cytoplasm
YIL168W YIL168W YIL168W hom pseudogene 3.58232679162959 0.000170273704604893 yes 44 0.000157790560039265 21 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Open reading frame, unlikely to produce a functional protein in S288C; in closely related species and other S. cerevisiae strain backgrounds YIL168W and adjacent ORF, YIL167W, constitute a single ORF encoding L-serine dehydratase serine family amino acid metabolic process L-serine ammonia-lyase activity cellular_component
YBR013C_p YBR013C YBR013C hom Uncharacterized 3.51607273734033 0.000218990487833763 yes 45 0.000297900681629017 55 NA Putative protein of unknown function, haploid deletion mutant exhibits synthetic phenotype with alpha-synuclein biological_process molecular_function cellular_component
YDR007W YDR007W TRP1 hom Verified 3.46211158092029 0.000267977453063898 yes 46 0.034096634134851 406 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA) tryptophan biosynthetic process phosphoribosylanthranilate isomerase activity cytoplasm
YOL113W YOL113W SKM1 hom Verified 3.4504613608893 0.000279814635477837 yes 47 0.000478753550894801 25 NA FT CELL DIVISION|PROTEIN PHOSPHORYLATION NUCLEUS|PLASMA MEMBRANE Member of the PAK family of serine/threonine protein kinases with similarity to Ste20p and Cla4p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth negative regulation of gene expression|cytokinetic cell separation|protein phosphorylation|sterol import protein serine/threonine kinase activity|protein kinase activity plasma membrane|nucleus
YMR001C-A_p YMR001C-A YMR001C-A hom Uncharacterized 3.43960758360449 0.000291279097488676 yes 48 0.000156383049112958 70 NA Putative protein of unknown function biological_process molecular_function cellular_component
YGL076C YGL076C RPL7A hom Verified 3.41043473265275 0.000324297028168238 yes 49 0.000377924350876053 19 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L7A; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7A has a paralog, RPL7B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit|cytoplasm
YLR307C-A_p YLR307C-A YLR307C-A hom Uncharacterized 3.40220937208245 0.000334217036959198 yes 50 9.30656748833223e-05 13 NA Putative protein of unknown function biological_process molecular_function cellular_component
YGL066W YGL066W SGF73 hom Verified 3.3855144829786 0.000355224801985796 yes 51 0.00111014259199722 35 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|RNA LOCALIZATION NUCLEUS HISTONE ACETYLTRANSFERASE SAGA complex subunit; has a role in anchoring the deubiquitination module into SAGA and SLIK complexes; involved in preinitiation complex assembly at promoters; human ortholog ataxin-7 is associated with spinocerebellar ataxia diseases; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay histone deubiquitination|mRNA export from nucleus|histone acetylation|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|protein complex assembly|chromatin modification histone acetyltransferase activity|enzyme activator activity|structural molecule activity DUBm complex|SLIK (SAGA-like) complex|SAGA complex
YDR200C YDR200C VPS64 hom Verified 3.35958868368719 0.000390292967396974 yes 52 0.00102872514147276 46 NA FT PROTEIN LOCALIZATION|CELL CYCLE|SIGNALING|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein required for cytoplasm to vacuole targeting of proteins; forms a complex with Far3p and Far7p to Far11p involved in recovery from pheromone-induced cell cycle arrest; mutant has increased aneuploidy tolerance re-entry into mitotic cell cycle after pheromone arrest|protein targeting to vacuole molecular_function endoplasmic reticulum membrane|cytoplasm
YIL025C_d YIL025C YIL025C hom Dubious 3.2435801022901 0.000590188077068723 yes 53 0.00175746210095264 39 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOR382W YOR382W FIT2 hom Verified 3.20569706735244 0.00067367875733588 yes 54 0.000117118083092505 12 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall siderophore transport molecular_function fungal-type cell wall
YGR248W YGR248W SOL4 hom Verified 3.20498655451157 0.000675343949648419 yes 55 0.000454030420100948 23 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS NUCLEUS 6-phosphogluconolactonase; protein abundance increases in response to DNA replication stress; SOL4 has a paralog, SOL3, that arose from the whole genome duplication pentose-phosphate shunt, oxidative branch 6-phosphogluconolactonase activity cytosol|nucleus|cytoplasm
YMR222C YMR222C FSH2 hom Verified 3.19100084998485 0.000708904315673171 yes 56 0.000380428878204842 30 NA Putative serine hydrolase that localizes to the cytoplasm; sequence is similar to S. cerevisiae Fsh1p and Fsh3p and the human candidate tumor suppressor OVCA2 biological_process molecular_function cytoplasm
YMR264W YMR264W CUE1 hom Verified 3.18477958811693 0.000724321492350309 yes 57 0.00169910966721723 96 NA FF|FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|PROTEOLYSIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION UBIQUITIN LIGASE COMPLEX Ubiquitin-binding protein; endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination; CUE1 has a paralog, CUE4, that arose from the whole genome duplication ER-associated protein catabolic process|establishment of protein localization to endoplasmic reticulum membrane ubiquitin-protein ligase activator activity Doa10p ubiquitin ligase complex|mitochondrion|integral to endoplasmic reticulum membrane
YKL115C_d YKL115C YKL115C hom Dubious 3.16698423681243 0.000770143336830977 yes 58 0.00058879593105408 36 NA Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1 Unknown Unknown Unknown
YIL125W YIL125W KGD1 hom Verified 3.1596487563105 0.000789797206088115 yes 59 0.00113755978193906 27 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA tricarboxylic acid cycle|2-oxoglutarate metabolic process oxoglutarate dehydrogenase (succinyl-transferring) activity mitochondrial nucleoid|mitochondrion|mitochondrial matrix|mitochondrial oxoglutarate dehydrogenase complex
YPL165C YPL165C SET6 hom Verified 3.14955990475065 0.000817582905430895 yes 60 0.000300993638123835 21 NA SET domain protein of unknown function; deletion heterozygote is sensitive to compounds that target ergosterol biosynthesis, may be involved in compound availability biological_process molecular_function cellular_component
YOR042W YOR042W CUE5 hom Verified 3.0823406135887 0.00102689841722588 no 61 0.00168556489284238 42 NA Protein containing a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern biological_process ubiquitin binding cytoplasm
YKR067W YKR067W GPT2 hom Verified 3.05889602261105 0.00111077119879116 no 62 0.0024352255664186 60 NA FT LIPID METABOLISM ENDOPLASMIC RETICULUM Glycerol-3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis; the most conserved motifs and functionally relevant residues are oriented towards the ER lumen phospholipid biosynthetic process glycerol-3-phosphate O-acyltransferase activity|glycerone-phosphate O-acyltransferase activity integral to membrane|lipid particle|endoplasmic reticulum|cytoplasm
YDL037C YDL037C BSC1 hom Verified 3.05361757197763 0.00113050052634701 no 63 0.00158636900988236 36 NA Protein of unconfirmed function, similar to cell surface flocculin Flo11p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression biological_process molecular_function cellular_component
YPL133C YPL133C RDS2 hom Verified 3.043899466762 0.00116766583617062 no 64 0.000305807435761497 17 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|SIGNALING|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS NUCLEUS Transcription factor involved in regulating gluconeogenesis and glyoxylate cycle genes; member of the zinc cluster family of proteins; confers resistance to ketoconazole positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source|positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter|cellular response to xenobiotic stimulus|positive regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus|cytoplasm
YNL032W YNL032W SIW14 hom Verified 3.01666383939223 0.0012778653102468 no 65 0.00119692823416275 58 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION Tyrosine phosphatase that plays a role in actin filament organization and endocytosis; localized to the cytoplasm actin filament organization|endocytosis|protein dephosphorylation|response to stress protein tyrosine phosphatase activity cytoplasm
YNL067W-B_p YNL067W-B YNL067W-B hom Uncharacterized 3.01409718739296 0.00128872612649224 no 66 0.00220322538645218 25 NA Putative protein of unknown function biological_process molecular_function cellular_component
YGR068C YGR068C ART5 hom Verified 2.99121666291018 0.00138934132986301 no 67 0.00143858957108781 40 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION Protein proposed to regulate the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membrane ubiquitin-dependent endocytosis ubiquitin protein ligase binding cellular_component
YDR465C YDR465C RMT2 hom Verified 2.98395660043442 0.00142273564384194 no 68 0.00297490882739388 13 NA FT NUCLEUS Arginine N5 methyltransferase; methylates ribosomal protein Rpl12 (L12) on Arg67; relative distribution to the nucleus increases upon DNA replication stress peptidyl-arginine methylation protein-arginine N5-methyltransferase activity nucleus|cytoplasm
YNL336W YNL336W COS1 hom Verified 2.9829758034764 0.00142730280562546 no 69 0.00180919749774305 49 NA Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins biological_process molecular_function integral to membrane|fungal-type vacuole
YOR097C_p YOR097C YOR097C hom Uncharacterized 2.97746360047608 0.00145322077042629 no 70 0.0032455074397918 67 NA Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; YOR097C is not an essential gene biological_process molecular_function cellular_component
YMR175W YMR175W SIP18 hom Verified 2.97440527300043 0.0014677853876802 no 71 0.000557671672632598 25 NA Phospholipid-binding hydrophilin; essential to overcome desiccation-rehydration process; expression is induced by osmotic stress cellular response to water deprivation phospholipid binding cytoplasm
YLR372W YLR372W SUR4 hom Verified 2.93207673630045 0.00168351770064868 no 72 0.0482400404457653 315 NA FF|FT VESICLE-MEDIATED TRANSPORT|KETONE METABOLISM|LIPID METABOLISM ENDOPLASMIC RETICULUM Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis post-Golgi vesicle-mediated transport|fatty acid elongation|fatty acid biosynthetic process|sphingolipid biosynthetic process fatty acid elongase activity integral to membrane|endoplasmic reticulum
YHR158C YHR158C KEL1 hom Verified 2.91443548772896 0.00178166223830085 no 73 0.00214283289021859 53 NA FT CELL CYCLE|MEMBRANE ORGANIZATION SITE OF POLARIZED GROWTH Protein required for proper cell fusion and cell morphology; functions in a complex with Kel2p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate negative regulation of exit from mitosis|regulation of cell shape|cell morphogenesis|cytogamy|plasma membrane fusion molecular_function mating projection tip|cellular bud neck|cytoplasm|cellular bud tip
YIR021W-A_p YIR021W-A YIR021W-A hom Uncharacterized 2.90751228789592 0.00182158015448401 no 74 0.00197316462355933 34 NA Putative protein of unknown function; identified by expression profiling and mass spectrometry biological_process molecular_function cellular_component
YBR095C YBR095C RXT2 hom Verified 2.89749523381817 0.00188077726867193 no 75 0.00560092722990976 92 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Subunit of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth conjugation with cellular fusion|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of transcription from RNA polymerase II promoter|negative regulation of chromatin silencing at telomere|negative regulation of chromatin silencing at rDNA|invasive growth in response to glucose limitation histone deacetylase activity Rpd3L-Expanded complex|nucleus|Rpd3L complex
YPL274W YPL274W SAM3 hom Verified 2.87022226141362 0.00205091682806265 no 76 0.00340531704553184 35 NA FT ENDOPLASMIC RETICULUM|PLASMA MEMBRANE High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p spermidine transport|putrescine transport|S-adenosylmethionine transport S-adenosylmethionine transmembrane transporter activity|spermidine transmembrane transporter activity|putrescine transmembrane transporter activity integral to membrane|plasma membrane
YDR283C YDR283C GCN2 hom Verified 2.84809448849807 0.00219909320803906 no 77 0.0131916720608968 292 NA FF|FT KETONE METABOLISM|CELL CYCLE|AMINO ACID METABOLISM|RESPONSE TO DNA DAMAGE|TRANSLATION|PROTEIN PHOSPHORYLATION RIBOSOME Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control cellular amino acid biosynthetic process|protein phosphorylation|regulation of translational initiation|DNA damage checkpoint protein homodimerization activity|protein kinase activity|eukaryotic translation initiation factor 2alpha kinase activity cytosolic ribosome
YOL018C YOL018C TLG2 hom Verified 2.84529212891104 0.00221853547577399 no 78 0.0452704164415227 260 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT GOLGI APPARATUS Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16) inositolphosphoceramide metabolic process|Golgi to vacuole transport|endocytosis|mannosyl-inositol phosphorylceramide metabolic process|protein exit from endoplasmic reticulum|vesicle fusion|CVT pathway SNAP receptor activity SNARE complex|trans-Golgi network|integral to endosome membrane
YCR061W_p YCR061W YCR061W hom Uncharacterized 2.82844927363452 0.00233870565626294 no 79 0.00277609087181415 82 NA Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; induced by treatment with 8-methoxypsoralen and UVA irradiation regulation of cell size molecular_function integral to membrane|cytoplasm
YKL064W YKL064W MNR2 hom Verified 2.82143055536512 0.00239049937758019 no 80 0.00161444993403837 31 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Vacuolar membrane protein required for magnesium homeostasis; putative magnesium transporter; has similarity to Alr1p and Alr2p, which mediate influx of Mg2+ and other divalent cations cellular magnesium ion homeostasis magnesium ion transmembrane transporter activity fungal-type vacuole membrane|integral to membrane
YBR161W YBR161W CSH1 hom Verified 2.80691517874435 0.00250092051444276 no 81 0.0010226187715532 41 NA FT LIPID METABOLISM Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Sur1p; CSH1 has a paralog, SUR1, that arose from the whole genome duplication glycosphingolipid biosynthetic process|sphingolipid biosynthetic process mannosyltransferase activity|transferase activity, transferring glycosyl groups integral to membrane|fungal-type vacuole
YDR008C_d YDR008C YDR008C hom Dubious 2.79884676987638 0.00256427341938594 no 82 0.0797593344024083 544 NA FF Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR377W YDR377W ATP17 hom Verified 2.79671205774512 0.00258127599811411 no 83 0.00330906790967679 72 NA FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS MITOCHONDRION Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis ATP synthesis coupled proton transport hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism mitochondrion|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
YPR166C YPR166C MRP2 hom Verified 2.726099920118 0.00320437970640757 no 84 0.0074363753470046 83 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YGL143C YGL143C MRF1 hom Verified 2.71798388365379 0.00328405186475567 no 85 0.0112449229237615 84 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial translation release factor, involved in stop codon recognition and hydrolysis of the peptidyl-tRNA bond during mitochondrial translation; lack of MRF1 causes mitochondrial genome instability translational termination|mitochondrial translational termination|mitochondrial translation translation release factor activity mitochondrion
YGL083W YGL083W SCY1 hom Verified 2.70224300643057 0.00344367023460649 no 86 0.00148749794774284 48 NA FT PROTEIN PHOSPHORYLATION Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase biological_process molecular_function clathrin-coated vesicle
YLL053C_p YLL053C YLL053C hom Uncharacterized 2.68860354335856 0.00358757896502128 no 87 0.00186109451924774 53 NA Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin biological_process molecular_function integral to membrane
YDR360W_d YDR360W OPI7 hom Dubious 2.68380333039032 0.00363949556302975 no 88 0.00404707822619949 67 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene VID21/YDR359C. Unknown Unknown Unknown
YGL095C YGL095C VPS45 hom Verified 2.66683974380653 0.00382840863802896 no 89 0.0382532440215032 289 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment vacuole inheritance|CVT pathway|positive regulation of SNARE complex assembly|Golgi vesicle fusion to target membrane|Golgi to vacuole transport|vacuole organization|vacuolar acidification|protein targeting to vacuole|Golgi to endosome transport unfolded protein binding|SNARE binding cytosol|SNARE complex|Golgi membrane|extrinsic to membrane
YMR273C YMR273C ZDS1 hom Verified 2.66275721084616 0.00387516559887749 no 90 0.00599934081226628 88 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CELL WALL ORG/BIOGENESIS|RNA LOCALIZATION|GENE SILENCING ENDOMEMBRANE SYSTEM|NUCLEUS|SITE OF POLARIZED GROWTH NUCLEAR PORE Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintaining Cdc55p in the cytoplasm where it promotes mitotic entry; involved in mitotic exit through Cdc14p regulation; interacts with silencing proteins at telomeres; has a role in Bcy1p localization; implicated in mRNA nuclear export; ZDS1 has a paralog, ZDS2, that arose from the whole genome duplication mRNA export from nucleus|positive regulation of G2/M transition of mitotic cell cycle|cell shape checkpoint|chromatin silencing|establishment of cell polarity|regulation of protein localization|cell aging protein phosphatase type 2A regulator activity incipient cellular bud site|nuclear pore|cellular bud neck|cellular bud tip|cytoplasm
YNL045W YNL045W LAP2 hom Verified 2.65408855840047 0.00397614766896243 no 91 0.00243739762164011 41 NA FT KETONE METABOLISM|LIPID METABOLISM|PROTEOLYSIS NUCLEUS Leucyl aminopeptidase yscIV (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus cellular lipid metabolic process|protein catabolic process aminopeptidase activity|leukotriene-A4 hydrolase activity|epoxide hydrolase activity nucleus|cytoplasm
YDR139C YDR139C RUB1 hom Verified 2.64384186809272 0.00409854706977455 no 92 0.00131746187545367 30 NA Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme) protein neddylation protein tag cytoplasm
YGL054C YGL054C ERV14 hom Verified 2.6380624327443 0.0041690614679097 no 93 0.0483235813469311 295 NA FF|FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|SIGNALING|CELL DIVISION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS COPII-coated vesicle protein; involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon; ERV14 has a paralog, ERV15, that arose from the whole genome duplication ascospore formation|ER to Golgi vesicle-mediated transport|axial cellular bud site selection molecular_function integral to membrane|ER to Golgi transport vesicle|endoplasmic reticulum membrane
YGR241C YGR241C YAP1802 hom Verified 2.61174083322261 0.00450412573424309 no 94 0.00648122895589519 91 NA FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1802 has a paralog, YAP1801, that arose from the whole genome duplication endocytosis clathrin binding actin cortical patch
YJL022W_d YJL022W YJL022W hom Dubious 2.59793099251771 0.00468936699391356 no 95 0.00577928576541293 49 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130 Unknown Unknown Unknown
YBR284W_p YBR284W YBR284W hom Uncharacterized 2.59528322423007 0.00472565006659293 no 96 0.00507700435337956 94 NA FT NUCLEOTIDE METABOLISM Putative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic defect of quadruple aah1 ade8 amd1 his1 mutant; null mutant exhibits longer telomeres, altered Ty mobility, decreased resistance to rapamycin and wortmannin; induced in response to hydrostatic pressure; not an essential gene; YBR284W has a paralog, YJL070C, that arose from the whole genome duplication biological_process AMP deaminase activity|molecular_function cellular_component
YPL039W_p YPL039W YPL039W hom Uncharacterized 2.58510463981268 0.00486747239050873 no 97 0.00777623239172736 93 NA Putative protein of unknown function; YPL039W is not an essential gene biological_process molecular_function cellular_component
YHR079C YHR079C IRE1 hom Verified 2.56944992422468 0.00509300560772564 no 98 0.00906246886424637 137 NA FF|FT RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress endoplasmic reticulum unfolded protein response|fungal-type cell wall organization|inositol metabolic process|protein phosphorylation unfolded protein binding|protein serine/threonine kinase activity|endoribonuclease activity|protein kinase activity|protein homodimerization activity nucleus
YGR170W YGR170W PSD2 hom Verified 2.55035692142165 0.00538063425985462 no 99 0.00532542382550894 66 NA FT LIPID METABOLISM GOLGI APPARATUS Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes, converts phosphatidylserine to phosphatidylethanolamine phosphatidylcholine biosynthetic process phosphatidylserine decarboxylase activity endosome
YLR261C_d YLR261C VPS63 hom Dubious 2.53061925946925 0.00569306849222861 no 100 0.0456216134829709 233 NA FF Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect Unknown Unknown Unknown
YER164W YER164W CHD1 hom Verified 2.52728636157077 0.00574738674131965 no 101 0.010480099166397 100 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION NUCLEUS|MITOCHONDRION|CHROMOSOME HISTONE ACETYLTRANSFERASE Chromatin remodeler that regulates various aspects of transcription; acts in in conjunction with Isw1b to regulate chromatin structure and maintain chromatin integrity during transcription elongation by RNAP II by preventing trans-histone exchange over coding regions; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SLIK complexes termination of RNA polymerase I transcription|ATP-dependent chromatin remodeling|nucleosome positioning|negative regulation of histone H3-K14 acetylation|termination of RNA polymerase II transcription|regulation of transcription by chromatin organization|regulation of transcriptional start site selection at RNA polymerase II promoter|nucleosome mobilization|Unknown|transcription elongation from RNA polymerase II promoter chromatin DNA binding|DNA-dependent ATPase activity|methylated histone residue binding|DNA binding|rDNA binding nuclear chromatin|SLIK (SAGA-like) complex|mitochondrion|SAGA complex|nucleolar chromatin
YPL025C_d YPL025C YPL025C hom Dubious 2.51854904039691 0.00589197362373067 no 102 0.0071634873643289 80 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YKR099W YKR099W BAS1 hom Verified 2.50920272584664 0.0060502008640148 no 103 0.0067164914524362 70 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes positive regulation of transcription from RNA polymerase II promoter core promoter sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|RNA polymerase II transcription factor recruiting transcription factor activity nucleus
YPL080C_d YPL080C YPL080C hom Dubious 2.50194040676218 0.00617573567747239 no 104 0.00919324412497304 89 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGL043W YGL043W DST1 hom Verified 2.48874725519104 0.00640970315226785 no 105 0.00616764662661433 111 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION NUCLEUS General transcription elongation factor TFIIS, enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites; maintains RNAPII elongation activity on ribosomal protein genes during conditions of transcriptional stress transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|mRNA cleavage|maintenance of transcriptional fidelity during DNA-dependent transcription elongation from RNA polymerase II promoter|tRNA transcription from RNA polymerase III promoter|regulation of mRNA 3'-end processing|positive regulation of transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|transcription antitermination|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter RNA polymerase II regulatory region DNA binding|RNA polymerase II core binding|core RNA polymerase II recruiting transcription factor activity nucleus
YJR073C YJR073C OPI3 hom Verified 2.48421885171208 0.00649179934410068 no 106 0.0215183072710055 227 NA FF|FT LIPID METABOLISM MITOCHONDRION Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis phosphatidylcholine biosynthetic process phosphatidyl-N-dimethylethanolamine N-methyltransferase activity|phosphatidyl-N-methylethanolamine N-methyltransferase activity mitochondrion|integral to membrane
YGR254W YGR254W ENO1 hom Verified 2.48077130309207 0.00655492276245159 no 107 0.00466326857242709 59 NA FT MEMBRANE ORGANIZATION|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Enolase I, a phosphopyruvate hydratase; catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is repressed in response to glucose; protein abundance increases in response to DNA replication stress regulation of vacuole fusion, non-autophagic|gluconeogenesis|glycolysis phosphopyruvate hydratase activity mitochondrion|phosphopyruvate hydratase complex|plasma membrane|fungal-type vacuole|cytoplasm
YPR042C YPR042C PUF2 hom Verified 2.46888109628122 0.00677681229985224 no 108 0.00868091776211021 99 NA Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding membrane-associated proteins nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay mRNA binding cytoplasm
YML100W YML100W TSL1 hom Verified 2.46591417578521 0.00683320375314512 no 109 0.00268233254444166 40 NA FT CARBOHYDRATE METABOLISM Large subunit of trehalose 6-phosphate synthase/phosphatase complex; Tps1p-Tps2p complex converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress; TSL1 has a paralog, TPS3, that arose from the whole genome duplication trehalose biosynthetic process|response to stress enzyme regulator activity|alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity|trehalose-phosphatase activity alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
YOL098C_p YOL098C YOL098C hom Uncharacterized 2.45442558896089 0.00705549327810046 no 110 0.00666624757159504 90 NA FT PROTEOLYSIS Putative metalloprotease biological_process molecular_function cytoplasm
YPL111W YPL111W CAR1 hom Verified 2.43884949533119 0.00736705167668255 no 111 0.00918888867513029 91 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS|SITE OF POLARIZED GROWTH Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance regulation of ornithine metabolic process|arginine catabolic process to ornithine manganese ion binding|arginase activity|ornithine carbamoyltransferase inhibitor activity|zinc ion binding cytosol|nucleus|mating projection tip|cytoplasm
YOR190W YOR190W SPR1 hom Verified 2.42673157684634 0.00761776174532555 no 112 0.0080992956961554 77 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance ascospore formation glucan exo-1,3-beta-glucosidase activity fungal-type cell wall|ascospore wall
YER030W YER030W CHZ1 hom Verified 2.42526277018185 0.00764865495228493 no 113 0.00223042254291769 39 NA FT CHROMATIN ORGANIZATION NUCLEUS Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif; protein abundance increases in response to DNA replication stress chromatin remodeling histone binding chromatin assembly complex|nucleus
YKR015C_p YKR015C YKR015C hom Uncharacterized 2.42349018668191 0.00768608428958245 no 114 0.00330842877209196 50 NA Putative protein of unknown function biological_process molecular_function cellular_component
YLR239C YLR239C LIP2 hom Verified 2.41935121910099 0.00777410987249154 no 115 0.0268368258922994 207 NA FF|FT KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM MITOCHONDRION Lipoyl ligase, involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups protein lipoylation ligase activity mitochondrion
YGR199W YGR199W PMT6 hom Verified 2.40711550167404 0.00803954183399418 no 116 0.00523731497318973 42 NA FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein O-mannosyltransferase, transfers mannose from dolichyl phosphate-D-mannose to protein serine/threonine residues of secretory proteins; reaction is essential for cell wall rigidity; member of a family of mannosyltransferases protein O-linked glycosylation|protein O-linked mannosylation dolichyl-phosphate-mannose-protein mannosyltransferase activity integral to membrane
YIL037C YIL037C PRM2 hom Verified 2.40424377564981 0.00810298118707952 no 117 0.009245083935477 103 NA Pheromone-regulated protein, predicted to have 4 transmembrane segments and a coiled coil domain; regulated by Ste12p; required for efficient nuclear fusion karyogamy involved in conjugation with cellular fusion molecular_function integral to membrane
YFL012W_p YFL012W YFL012W hom Uncharacterized 2.39902718869373 0.00821934702522187 no 118 0.0139765556920996 116 NA Putative protein of unknown function; transcribed during sporulation; null mutant exhibits increased resistance to rapamycin biological_process molecular_function cellular_component
YJL007C_d YJL007C YJL007C hom Dubious 2.39337615395874 0.00834705810170929 no 119 0.00683026603367174 63 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YKL126W YKL126W YPK1 hom Verified 2.39179722339793 0.0083830512812295 no 120 0.117754354014056 584 NA FF|FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Serine/threonine protein kinase; phosphorylates and downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p (inhibitors of serine:palmitoyl-coenzyme A transferase) by phosphorylation in response to compromised sphingolipid synthesis; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK; YPK1 has a paralog, YPK2, that arose from the whole genome duplication eisosome assembly|protein autophosphorylation|negative regulation of phospholipid translocation|protein phosphorylation protein serine/threonine kinase activity cytosol|plasma membrane|cellular bud neck
YML121W YML121W GTR1 hom Verified 2.38884360436486 0.00845074773709577 no 121 0.0207273773348443 177 NA FF|FT PROTEIN LOCALIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|GENE SILENCING NUCLEUS Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB phosphate ion transport|transcription from RNA polymerase I promoter|transcription from RNA polymerase III promoter|chromatin silencing at telomere GDP binding|GTP binding fungal-type vacuole membrane|EGO complex|nucleus|late endosome membrane|cytoplasm
YDR307W_p YDR307W PMT7 hom Uncharacterized 2.38583446424647 0.00852020968215011 no 122 0.00676750437304654 83 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Putative protein mannosyltransferase similar to Pmt1p; has a potential role in protein O-glycosylation biological_process molecular_function integral to membrane|endoplasmic reticulum
YMR120C YMR120C ADE17 hom Verified 2.38371292806365 0.00856948312615071 no 123 0.00574573576162681 73 NA FT NUCLEOTIDE METABOLISM Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE17 has a paralog, ADE16, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine purine nucleotide biosynthetic process|'de novo' IMP biosynthetic process phosphoribosylaminoimidazolecarboxamide formyltransferase activity|IMP cyclohydrolase activity cytosol|plasma membrane
YPL017C YPL017C IRC15 hom Verified 2.37537402708063 0.00876558770925787 no 124 0.0175680930937236 132 NA FT PROTEIN LOCALIZATION|CELL CYCLE|OXIDATION-REDUCTION PROCESS|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION CYTOSKELETON Microtubule associated protein; regulates microtubule dynamics; required for accurate meiotic chromosome segregation; null mutant displays large budded cells due to delayed mitotic progression, increased levels of spontaneous Rad52 foci microtubule nucleation|mitotic recombination|microtubule anchoring|meiotic sister chromatid segregation|attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|positive regulation of mitotic cell cycle microtubule binding|S-adenosylmethionine-dependent methyltransferase activity microtubule|cytoplasm
YBR031W YBR031W RPL4A hom Verified 2.37428248001277 0.00879154644985508 no 125 0.00683053819754445 85 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L4A; N-terminally acetylated; homologous to mammalian ribosomal protein L4 and bacterial L4; RPL4A has a paralog, RPL4B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YDR046C YDR046C BAP3 hom Verified 2.37053171706166 0.00888125992757866 no 126 0.0064848614533054 48 NA FT MITOCHONDRION|PLASMA MEMBRANE Amino acid permease; involved in uptake of cysteine, leucine, isoleucine and valine; BAP3 has a paralog, BAP2, that arose from the whole genome duplication amino acid transport|transmembrane transport amino acid transmembrane transporter activity mitochondrion|integral to membrane|plasma membrane
YOL155C YOL155C HPF1 hom Verified 2.3701238184652 0.00889106454304642 no 127 0.0113028810011755 121 NA FT CELL WALL ORG/BIOGENESIS Haze-protective mannoprotein that reduces the particle size of aggregated proteins in white wines fungal-type cell wall organization glucosidase activity fungal-type cell wall|extracellular region
YDR296W YDR296W MHR1 hom Verified 2.35063237802016 0.00937076993170893 no 128 0.017572729475517 111 NA FT MITOCHONDRION ORGANIZATION|RESPONSE TO OXIDATIVE STRESS NUCLEUS|MITOCHONDRION Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress cellular response to oxidative stress|positive regulation of mitochondrial DNA replication|regulation of transcription, DNA-dependent|mitochondrial genome maintenance|DNA recombination single-stranded DNA binding|recombinase activity|DNA binding mitochondrion|nucleus
YDL137W YDL137W ARF2 hom Verified 2.34757769287054 0.00944796594352832 no 129 0.0109973855235894 103 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|RESPONSE TO NUTRIENT LEVELS GOLGI APPARATUS ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; ARF2 has a paralog, ARF1, that arose from the whole genome duplication ER to Golgi vesicle-mediated transport|macroautophagy|intra-Golgi vesicle-mediated transport GTPase activity cytosol|Golgi-associated vesicle
YGL236C YGL236C MTO1 hom Verified 2.34687876969224 0.00946570665723598 no 130 0.0139022817322163 79 NA FT RNA PROCESSING|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants mitochondrial tRNA wobble uridine modification molecular_function mitochondrion
YDL211C_p YDL211C YDL211C hom Uncharacterized 2.3453009994062 0.00950586221993608 no 131 0.00932480298802792 85 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole biological_process molecular_function fungal-type vacuole
YLR410W YLR410W VIP1 hom Verified 2.34190555903082 0.00959278448412784 no 132 0.00578659127606338 57 NA FT CYTOSKELETON Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; IP7 production is important for phosphate signaling; involved in cortical actin cytoskeleton function, and invasive pseudohyphal growth analogous to S. pombe asp1 inositol phosphate biosynthetic process inositol hexakisphosphate 1-kinase activity|inositol hexakisphosphate 3-kinase activity|inositol heptakisphosphate kinase activity|inositol hexakisphosphate 4-kinase activity|inositol hexakisphosphate 6-kinase activity cytoplasm
YMR285C YMR285C NGL2 hom Verified 2.33345340441512 0.00981218057907142 no 133 0.00497337854748615 73 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p; NGL2 has a paralog, NGL3, that arose from the whole genome duplication rRNA processing endoribonuclease activity intracellular
YDR249C_p YDR249C YDR249C hom Uncharacterized 2.31571745447663 0.0102868503783735 no 134 0.0059652359185376 64 NA Putative protein of unknown function biological_process molecular_function cellular_component
YPR031W YPR031W NTO1 hom Verified 2.31341726479755 0.010349854381363 no 135 0.0164082484781584 101 NA FT CHROMATIN ORGANIZATION NUCLEUS HISTONE ACETYLTRANSFERASE Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3 histone acetylation histone acetyltransferase activity|methylated histone residue binding nucleus|NuA3 histone acetyltransferase complex|cytoplasm
YPR118W YPR118W MRI1 hom Verified 2.31332746747158 0.0103523208090255 no 136 0.0137369272010837 62 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS 5'-methylthioribose-1-phosphate isomerase; catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway L-methionine salvage from methylthioadenosine S-methyl-5-thioribose-1-phosphate isomerase activity nucleus|cytoplasm
YGL228W YGL228W SHE10 hom Verified 2.31086090109727 0.0104202696538838 no 137 0.00952348012894345 86 NA FT MITOCHONDRION Putative glycosylphosphatidylinositol (GPI)-anchored protein of unknown function; overexpression causes growth arrest biological_process molecular_function cellular_component
YKL138C YKL138C MRPL31 hom Verified 2.31066561136881 0.0104256660551723 no 138 0.0201465930370821 165 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrial large ribosomal subunit
YAL024C YAL024C LTE1 hom Verified 2.31038156157705 0.0104335194932333 no 139 0.0340146249143197 228 NA FF|FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|SIGNALING|CELL DIVISION Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures regulation of exit from mitosis|mitotic cell cycle spindle orientation checkpoint|vesicle-mediated transport guanyl-nucleotide exchange factor activity cellular bud
YER181C_d YER181C YER181C hom Dubious 2.29176472707104 0.0109596115509203 no 140 0.00917064540681493 103 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative data; extensively overlaps a Ty1 LTR; protein product is detected in highly purified mitochondria in high-throughput studies Unknown Unknown Unknown
YCR002C YCR002C CDC10 hom Verified 2.29143838523792 0.0109690358186836 no 141 0.0190615102679716 152 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Component of the septin ring, required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells; N-terminus interacts with phosphatidylinositol-4,5-bisphosphate; protein abundance increases under DNA damage stress sporulation|maintenance of cell polarity|exit from mitosis|cell cycle cytokinesis|septin ring assembly protein complex scaffold|structural molecule activity|GTP binding|GTPase activity|1-phosphatidylinositol binding spindle microtubule|ascospore-type prospore|septin complex|prospore membrane|mating projection base|meiotic spindle|septin filament array|cellular bud neck septin ring|mating projection tip
YKR026C YKR026C GCN3 hom Verified 2.28673928206723 0.0111055226967152 no 142 0.0276571627968564 325 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression regulation of translational initiation enzyme regulator activity|guanyl-nucleotide exchange factor activity|translation initiation factor activity eukaryotic translation initiation factor 2B complex|guanyl-nucleotide exchange factor complex
YMR224C YMR224C MRE11 hom Verified 2.25200096997935 0.0121611053594989 no 143 0.014354030116305 136 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION Subunit of the MRX complex with Rad50p and Xrs2p; complex functions in repair of DNA double-strand breaks and in telomere stability; exhibits nuclease activity that appears to be required for MRX function; widely conserved; forms nuclear foci upon DNA replication stress DNA repair|meiotic DNA double-strand break formation|double-strand break repair via nonhomologous end joining|base-excision repair|ascospore formation|meiotic DNA double-strand break processing|double-strand break repair via break-induced replication|regulation of transcription during meiosis 3'-5' exonuclease activity|protein complex scaffold|double-stranded telomeric DNA binding|adenylate kinase activity|telomeric DNA binding|single-stranded telomeric DNA binding|endodeoxyribonuclease activity|G-quadruplex DNA binding|endonuclease activity mitochondrion|nucleus|Mre11 complex
YML016C YML016C PPZ1 hom Verified 2.24976923405445 0.0122317989875839 no 144 0.0186565614009723 92 NA FT PROTEIN LOCALIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS NUCLEUS|PLASMA MEMBRANE Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance cellular sodium ion homeostasis|cellular protein localization|protein dephosphorylation protein serine/threonine phosphatase activity extrinsic to plasma membrane|nucleus|cytoplasm
YML057W YML057W CMP2 hom Verified 2.24820776880708 0.0122814722674367 no 145 0.00511936231741209 58 NA FT SIGNALING|ION HOMEOSTASIS|ION HOMEOSTASIS Calcineurin A; one isoform (the other is CNA1) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1 adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|cellular ion homeostasis calcium-dependent protein serine/threonine phosphatase activity calcineurin complex|cytoplasm
YLR412C-A_p YLR412C-A YLR412C-A hom Uncharacterized 2.23717230790454 0.0126375402571822 no 146 0.0118472442450179 90 NA Putative protein of unknown function biological_process molecular_function cellular_component
YBR296C-A_p YBR296C-A YBR296C-A hom Uncharacterized 2.23692750243081 0.0126455393588841 no 147 0.0174467395670837 137 NA Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YNL194C YNL194C YNL194C hom Verified 2.23618467094155 0.0126698384565263 no 148 0.0101764058872077 86 NA FT ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Integral membrane protein required for sporulation and plasma membrane sphingolipid content; has sequence similarity to SUR7 and FMP45; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; GFP-fusion protein is more abundant at MCCs (membrane compartment occupied by Can1) in the presence of glycerol and oleate ascospore formation molecular_function cell cortex|integral to membrane|endoplasmic reticulum|plasma membrane|cytoplasm
YDR384C YDR384C ATO3 hom Verified 2.23466156447878 0.0127197878743248 no 149 0.00955830676473403 75 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION|PLASMA MEMBRANE Plasma membrane protein, regulation pattern suggests a possible role in export of ammonia from the cell; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family of putative transporters ammonium transport|nitrogen utilization|transmembrane transport ammonium transmembrane transporter activity mitochondrion|integral to membrane|plasma membrane
YDR502C YDR502C SAM2 hom Verified 2.21874879381809 0.0132519097231831 no 150 0.00638906909629126 65 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM2 has a paralog, SAM1, that arose from the whole genome duplication methionine metabolic process|S-adenosylmethionine biosynthetic process methionine adenosyltransferase activity cellular_component
YAL062W YAL062W GDH3 hom Verified 2.20747900893939 0.0136403059581887 no 151 0.00775346285405095 64 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS NUCLEUS|MITOCHONDRION NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources; GDH3 has a paralog, GDH1, that arose from the whole genome duplication glutamate biosynthetic process|ammonia assimilation cycle glutamate dehydrogenase (NADP+) activity mitochondrion|nucleus
YNL314W YNL314W DAL82 hom Verified 2.20572421482172 0.0137016576927271 no 152 0.0111685703894202 139 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS NUCLEUS Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain allantoin catabolic process|nitrogen catabolite activation of transcription from RNA polymerase II promoter sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nucleus
YKR014C YKR014C YPT52 hom Verified 2.20173319658837 0.0138420801731413 no 153 0.0170412112895796 137 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|VACUOLAR TRANSPORT ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Rab family GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; protein abundance increases in response to DNA replication stress endocytosis|protein targeting to vacuole GTPase activity late endosome
YPR172W_p YPR172W YPR172W hom Uncharacterized 2.19846507604134 0.0139579903337435 no 154 0.0114268178737339 112 NA FT OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM NUCLEUS Putative pyridoxal 5'-phosphate synthase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; YPR172W has a paralog, YLR456W, that arose from the whole genome duplication biological_process molecular_function nucleus|cytoplasm
YDR420W YDR420W HKR1 hom Verified 2.19010871618336 0.0142581766279529 no 155 0.00628856331839155 56 NA FT CELL CYCLE|SIGNALING|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Mucin family member that functions as an osmosensor in the Sho1p-mediated HOG pathway with Msb2p; proposed to be a negative regulator of filamentous growth; mutant displays defects in beta-1,3 glucan synthesis and bud site selection (1->3)-beta-D-glucan biosynthetic process|fungal-type cell wall organization|osmosensory signaling pathway via Sho1 osmosensor|hyperosmotic response|cellular bud site selection osmosensor activity site of polarized growth|plasma membrane
YOL145C YOL145C CTR9 hom Verified 2.18958652372975 0.0142771186229677 no 156 0.0255714822833602 199 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|GENE SILENCING NUCLEUS|CHROMOSOME RNA POL II, HOLOENZYME Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cyclin genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; contains TPR repeats transcription elongation from RNA polymerase I promoter|mRNA 3'-end processing|regulation of chromatin silencing at telomere|snoRNA transcription from an RNA polymerase II promoter|regulation of transcription by chromatin organization|transcription from RNA polymerase I promoter|regulation of histone H3-K4 methylation|regulation of transcription-coupled nucleotide-excision repair|regulation of transcription initiation from RNA polymerase II promoter|snoRNA 3'-end processing|Unknown|regulation of transcription involved in G1 phase of mitotic cell cycle|transcription elongation from RNA polymerase II promoter RNA polymerase II core binding|triplex DNA binding|RNA polymerase II transcription factor binding transcription factor activity transcriptionally active chromatin|nucleus|Cdc73/Paf1 complex
YOL152W YOL152W FRE7 hom Verified 2.1804162408894 0.014613310674907 no 157 0.0151647189926387 113 NA FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY PLASMA MEMBRANE Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels iron ion transport|copper ion import ferric-chelate reductase activity integral to membrane|plasma membrane
YOR092W YOR092W ECM3 hom Verified 2.17151728242327 0.0149460460946961 no 158 0.0115835291760325 74 NA FT CELL WALL ORG/BIOGENESIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from ER to cytoplasm upon DNA replication stress; ECM3 has a paralog, YNL095C, that arose from the whole genome duplication fungal-type cell wall organization ATPase activity integral to membrane|endoplasmic reticulum
YLR183C YLR183C TOS4 hom Verified 2.16785985555848 0.0150846755281491 no 159 0.0173622869970944 120 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION|CHROMOSOME Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; expression is periodic and peaks in G1; relative distribution to the nucleus increases upon DNA replication stress; TOS4 has a paralog, PLM2, that arose from the whole genome duplication response to DNA damage stimulus chromatin binding nuclear chromatin|Rpd3L-Expanded complex|mitochondrion|nucleus|cytoplasm
YLR349W_d YLR349W YLR349W hom Dubious 2.16366677067281 0.0152449665096284 no 160 0.0115189433692606 60 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF DIC1/YLR348C Unknown Unknown Unknown
YBR009C YBR009C HHF1 hom Verified 2.16335279898512 0.0152570275083749 no 161 0.0167901058524744 165 NA FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Histone H4, core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity chromatin assembly or disassembly|sexual sporulation resulting in formation of a cellular spore|histone H3-K79 methylation DNA binding replication fork protection complex|nuclear nucleosome
YEL014C_d YEL014C YEL014C hom Dubious 2.15987753151524 0.0153910757809809 no 162 0.00851100313112219 79 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YNL274C YNL274C GOR1 hom Verified 2.15972015390129 0.015397170020915 no 163 0.00818252446111784 73 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS NUCLEUS|MITOCHONDRION Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress glyoxylate catabolic process|metabolic process oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|glyoxylate reductase activity mitochondrion|nucleus|cytoplasm
YNL198C_d YNL198C YNL198C hom Dubious 2.15875383201734 0.0154346349924977 no 164 0.0124284435702837 114 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPR049C YPR049C ATG11 hom Verified 2.15279930455482 0.015667227418284 no 165 0.0212912961833368 148 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|PEROXISOME ORGANIZATION Adapter protein for pexophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; directs receptor-bound cargo to the phagophore assembly site (PAS) for packaging into vesicles; required for recruiting other proteins to the (PAS) piecemeal microautophagy of nucleus|mitochondrion degradation|peroxisome degradation|protein localization to pre-autophagosomal structure|CVT pathway protein complex scaffold pre-autophagosomal structure|extrinsic to membrane
YDR393W YDR393W SHE9 hom Verified 2.15201978522205 0.0156978980514996 no 166 0.0192918372490703 136 NA FT MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial inner membrane protein required for normal mitochondrial morphology, may be involved in fission of the inner membrane; forms a homo-oligomeric complex mitochondrion organization|inner mitochondrial membrane organization molecular_function mitochondrial inner membrane
YPR036W YPR036W VMA13 hom Verified 2.15012472408355 0.0157726752097403 no 167 0.0473166712483831 221 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Subunit H of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; serves as an activator or a structural stabilizer of the V-ATPase vacuolar acidification proton-transporting ATPase activity, rotational mechanism vacuolar proton-transporting V-type ATPase, V1 domain|fungal-type vacuole membrane|integral to membrane
YGR157W YGR157W CHO2 hom Verified 2.1458327153469 0.0159431637513333 no 168 0.0195516905412863 105 NA FT LIPID METABOLISM Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis phosphatidylcholine biosynthetic process phosphatidylethanolamine N-methyltransferase activity integral to membrane|endoplasmic reticulum
YOL042W YOL042W NGL1 hom Verified 2.13768768217426 0.0162710499528891 no 169 0.0135647823130528 77 NA FT MITOCHONDRION Putative endonuclease, has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process endonuclease activity mitochondrion
YPL100W YPL100W ATG21 hom Verified 2.13688484754414 0.0163036793628035 no 170 0.0178996922051812 132 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Phosphoinositide binding protein required for vesicle formation in the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein piecemeal microautophagy of nucleus|vesicle organization|mitochondrion degradation|macroautophagy|protein localization to pre-autophagosomal structure|CVT pathway|protein lipidation phosphatidylinositol binding endosome|cytosol|fungal-type vacuole membrane
YDL190C YDL190C UFD2 hom Verified 2.13366906500386 0.0164349400297886 no 171 0.0195817716517073 128 NA FT PROTEOLYSIS NUCLEUS Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3 ER-associated protein catabolic process|protein ubiquitination|ubiquitin-dependent protein catabolic process|response to stress ubiquitin-ubiquitin ligase activity nucleus|cytoplasm
YML027W YML027W YOX1 hom Verified 2.12871558013262 0.0166388995109557 no 172 0.0115120989408877 80 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE NUCLEUS|CHROMOSOME Homeobox transcriptional repressor; binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression is cell cycle-regulated; potential Cdc28p substrate; relocalizes from nucleus to cytoplasm upon DNA replication stress; YOX1 has a paralog, YHP1, that arose from the whole genome duplication negative regulation of transcription involved in G1 phase of mitotic cell cycle RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription nuclear chromatin|nucleus
YNL324W_d YNL324W YNL324W hom Dubious 2.12421395855902 0.0168261282725804 no 173 0.0297086249106002 159 NA Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR376C YLR376C PSY3 hom Verified 2.1241756361837 0.0168277298573754 no 174 0.017136013970489 144 NA FT RESPONSE TO DNA DAMAGE NUCLEUS Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function; structural analysis reveals a similar DNA-binding region in both Psy3p and Csm2p and that both regions work together to form a single DNA binding site; deletion of PSY3 results in a mutator phenotype; deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C recombinational repair|error-free translesion synthesis molecular_function nucleus|Shu complex|cytoplasm
YKL106W YKL106W AAT1 hom Verified 2.11825600290019 0.0170766962904633 no 175 0.0114105158037288 119 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis aspartate catabolic process|chronological cell aging|replicative cell aging|asparagine biosynthetic process from oxaloacetate|aspartate biosynthetic process L-aspartate:2-oxoglutarate aminotransferase activity mitochondrion
YGR163W YGR163W GTR2 hom Verified 2.11704340888209 0.0171280819277068 no 176 0.040308052303468 259 NA FF|FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|MEMBRANE ORGANIZATION NUCLEUS|CHROMOSOME Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD microautophagy|positive regulation of transcription from RNA polymerase II promoter GTP binding nuclear chromatin|fungal-type vacuole membrane|integral to membrane|EGO complex|nucleus|late endosome membrane|cytoplasm
YDR065W YDR065W RRG1 hom Verified 2.11456101163549 0.0172336897947439 no 177 0.0171622501971518 145 NA FT ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS MITOCHONDRION Protein of unknown function, required for vacuolar acidification and mitochondrial genome maintenance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies mitochondrial genome maintenance|vacuolar acidification molecular_function mitochondrion
YBR094W YBR094W PBY1 hom Verified 2.11304999597702 0.0172982444522385 no 178 0.0105166190325578 87 NA Putative tubulin tyrosine ligase associated with P-bodies; forms cytoplasmic foci upon DNA replication stress nuclear-transcribed mRNA catabolic process|biological_process molecular_function cytoplasmic mRNA processing body|cytoplasm
YMR070W YMR070W MOT3 hom Verified 2.10360895139766 0.0177062862375101 no 179 0.0310497355499888 220 NA FT TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM NUCLEUS Transcriptional repressor and activator with two C2-H2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes in response to hyperosmotic stress; contributes to recruitment of the Tup1p-Cyc8p general repressor to promoters; involved in positive transcriptional regulation of CWP2 and other genes; can form the [MOT3+] prion cellular hyperosmotic response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of ergosterol biosynthetic process|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II repressing transcription factor binding|RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding nucleus
YDR272W YDR272W GLO2 hom Verified 2.10326490820408 0.0177213095811955 no 180 0.0154666685174104 119 NA FT KETONE METABOLISM|CARBOHYDRATE METABOLISM Cytoplasmic glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate cellular carbohydrate metabolic process|methylglyoxal catabolic process to D-lactate hydroxyacylglutathione hydrolase activity cytoplasm
YCL023C_d YCL023C YCL023C hom Dubious 2.09070615726963 0.0182772063547716 no 181 0.0119674288430118 62 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF KCC4 Unknown Unknown Unknown
YMR150C YMR150C IMP1 hom Verified 2.08793690081178 0.0184017634805958 no 182 0.0124589248975821 82 NA FT PROTEIN LOCALIZATION|PROTEOLYSIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p protein processing involved in protein targeting to mitochondrion endopeptidase activity mitochondrion|mitochondrial inner membrane peptidase complex
YLR389C YLR389C STE23 hom Verified 2.08153440214474 0.0186925093031765 no 183 0.0109685381338591 112 NA FT PROTEOLYSIS Metalloprotease involved, with homolog Axl1p, in N-terminal processing of pro-a-factor to the mature form; expressed in both haploids and diploids; member of the insulin-degrading enzyme family peptide pheromone maturation metallopeptidase activity|metalloendopeptidase activity extrinsic to membrane
YPL004C YPL004C LSP1 hom Verified 2.07947455684819 0.018786876995368 no 184 0.0144444824718637 85 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION MITOCHONDRION Primary component of eisosomes, which are large immobile patch structures at the cell cortex associated with endocytosis, along with Pil1p and Sur7p; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; member of the BAR domain family negative regulation of protein kinase activity|endocytosis|response to heat lipid binding mitochondrial outer membrane|eisosome|mitochondrion|plasma membrane|cytoplasm
YHL035C YHL035C VMR1 hom Verified 2.0787031108927 0.0188223234407898 no 185 0.0208230682041585 154 NA FT NUCLEOTIDE METABOLISM MITOCHONDRION Vacuolar membrane protein involved in multiple drug resistance and metal sensitivity; ATP-binding cassette (ABC) family member involved in drug transport; potential Cdc28p substrate; induced under respiratory conditions transport|response to drug|response to metal ion|drug transport ATPase activity, coupled to transmembrane movement of substances fungal-type vacuole membrane|mitochondrion|integral to membrane|ribosome
YDR484W YDR484W VPS52 hom Verified 2.07577609370347 0.0189573321956005 no 186 0.057904954124212 233 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT GOLGI APPARATUS|CYTOSKELETON Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin actin filament-based process|Golgi to vacuole transport|retrograde transport, endosome to Golgi protein binding Golgi apparatus|GARP complex
YDR285W YDR285W ZIP1 hom Verified 2.07327056647064 0.0190735531630549 no 187 0.0206657309780351 117 NA FT CELL CYCLE NUCLEUS|CHROMOSOME Transverse filament protein of the synaptonemal complex; required for normal levels of meiotic recombination and pairing between homologous chromosome during meiosis; potential Cdc28p substrate synapsis|reciprocal meiotic recombination chromatin binding|SUMO polymer binding transverse filament
YER105C YER105C NUP157 hom Verified 2.0634144538972 0.0195366339259479 no 188 0.00715669049894077 76 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and tethering of DNA to the nuclear periphery; both Nup170p and NUP157p are similar to human Nup155p; NUP157 has a paralog, NUP170, that arose from the whole genome duplication nucleocytoplasmic transport|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|mitotic cell cycle spindle assembly checkpoint|nuclear pore complex assembly|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery structural constituent of nuclear pore integral to membrane|nuclear pore|nuclear pore inner ring
YBL019W YBL019W APN2 hom Verified 2.06321352980151 0.0195461726178718 no 189 0.00896208571313312 55 NA FT RESPONSE TO DNA DAMAGE NUCLEUS Class II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII base-excision repair DNA-(apurinic or apyrimidinic site) lyase activity|double-stranded DNA specific 3'-5' exodeoxyribonuclease activity|phosphoric diester hydrolase activity nucleus
YDR076W YDR076W RAD55 hom Verified 2.05787149782012 0.0198012352117141 no 190 0.026112968007736 207 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p DNA recombinase assembly|heteroduplex formation|meiotic DNA recombinase assembly|double-strand break repair via single-strand annealing DNA-dependent ATPase activity|protein heterodimerization activity nucleus|Rhp55-Rhp57 complex
YDR297W YDR297W SUR2 hom Verified 2.05665138445935 0.0198598858466424 no 191 0.0258403985129588 167 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis sphingolipid metabolic process sphingosine hydroxylase activity integral to membrane|endoplasmic reticulum membrane
YGL162W YGL162W SUT1 hom Verified 2.05398358015534 0.0199886404768213 no 192 0.016244461602533 110 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Transcription factor of the Zn2Cys6 family involved in sterol uptake; involved in induction of hypoxic gene expression; relocalizes from nucleus to cytoplasm upon DNA replication stress positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter RNA polymerase II repressing transcription factor binding nucleus
YPL058C YPL058C PDR12 hom Verified 2.05252851822504 0.0200591632224772 no 193 0.0203749214340586 143 NA FT KETONE METABOLISM|NUCLEOTIDE METABOLISM PLASMA MEMBRANE Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity propionate metabolic process|transport|organic acid transport xenobiotic-transporting ATPase activity|organic acid transmembrane transporter activity integral to membrane|plasma membrane
YDR225W YDR225W HTA1 hom Verified 2.05077561228916 0.0201444017901634 no 194 0.0225632374180999 186 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME RSC COMPLEX Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p DNA repair|chromatin assembly or disassembly|negative regulation of transcription from RNA polymerase II promoter DNA binding replication fork protection complex|nuclear nucleosome
YBR131W YBR131W CCZ1 hom Verified 2.05021082530977 0.0201719310359199 no 195 0.018309896831894 171 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Protein involved in vacuolar assembly, essential for autophagy and the cytoplasm-to-vacuole pathway autophagy|autophagic vacuole fusion|vacuolar transport|vesicle docking|protein targeting to vacuole guanyl-nucleotide exchange factor activity Mon1-Ccz1 complex|membrane
YNL265C YNL265C IST1 hom Verified 2.0389219862019 0.0207289071115103 no 196 0.0249853193771242 175 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT Protein with a positive role in the multivesicular body sorting pathway; functions and forms a complex with Did2p; recruitment to endosomes is mediated by the Vps2p-Vps24p subcomplex of ESCRT-III; also interacts with Vps4p late endosome to vacuole transport via multivesicular body sorting pathway molecular_function endosome|cytoplasm
YLR433C YLR433C CNA1 hom Verified 2.02374627386172 0.0214981323686256 no 197 0.0122081401275497 126 NA FT SIGNALING|ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS Calcineurin A; one isoform (the other is CMP2) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1 adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|fungal-type cell wall organization|cellular ion homeostasis calcium-dependent protein serine/threonine phosphatase activity calcineurin complex|cytoplasm
YHL031C YHL031C GOS1 hom Verified 2.02130524769237 0.0216240881367512 no 198 0.0591392159390833 296 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|GOLGI APPARATUS v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28 Golgi vesicle transport|vesicle fusion SNAP receptor activity SNARE complex|integral to membrane|Golgi medial cisterna
YOL115W YOL115W PAP2 hom Verified 2.01748773348949 0.0218223199262917 no 199 0.0276540363249716 192 NA FT CELL CYCLE|RNA PROCESSING|RESPONSE TO DNA DAMAGE|CELL DIVISION NUCLEUS Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Trf5p polyadenylation-dependent mRNA catabolic process|nuclear polyadenylation-dependent CUT catabolic process|base-excision repair|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent snRNA catabolic process|ncRNA polyadenylation|histone mRNA catabolic process|nuclear polyadenylation-dependent mRNA catabolic process|nuclear polyadenylation-dependent antisense transcript catabolic process|U4 snRNA 3'-end processing|nuclear mRNA surveillance of mRNA 3'-end processing|polyadenylation-dependent snoRNA 3'-end processing|snoRNA polyadenylation|tRNA modification 5'-deoxyribose-5-phosphate lyase activity|polynucleotide adenylyltransferase activity nucleolus|nucleus|TRAMP complex
YJL066C YJL066C MPM1 hom Verified 2.0157305293241 0.0219140807041133 no 200 0.0286992846510611 160 NA FT MITOCHONDRION Mitochondrial intermembrane space protein of unknown function biological_process molecular_function mitochondrion|extrinsic to membrane
YDR423C YDR423C CAD1 hom Verified 2.01197264983962 0.0221114100743365 no 201 0.0232360886050832 148 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS AP-1-like basic leucine zipper (bZIP) transcriptional activator; involved in stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins; binds consensus sequence TTACTAA; CAD1 has a paralog, YAP1, that arose from the whole genome duplication cellular response to cadmium ion|positive regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus|cytoplasm
YNL123W YNL123W NMA111 hom Verified 2.00741193970013 0.0223529092750421 no 202 0.0348045063531902 233 NA FT LIPID METABOLISM|PROTEOLYSIS NUCLEUS Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases apoptotic process|cellular lipid metabolic process|protein catabolic process|cellular response to heat serine-type peptidase activity nucleus
YOR338W_p YOR338W YOR338W hom Uncharacterized 2.00609275448468 0.0224231763795408 no 203 0.0142150818877522 119 NA FT TRANSCRIPTION FROM RNA POL II Putative protein of unknown function; YOR338W transcription is regulated by Azf1p and its transcript is a specific target of the G protein effector Scp160p; identified as being required for sporulation in a high-throughput mutant screen; YOR338W has a paralog, FUN19, that arose from the whole genome duplication ascospore formation|positive regulation of transcription from RNA polymerase II promoter molecular_function cellular_component
YMR121C YMR121C RPL15B hom Verified 2.001819168235 0.0226520918107002 no 204 0.0171115547388593 111 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress cytoplasmic translation structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YNL134C YNL134C YNL134C hom Verified 1.99985433845079 0.02275799750163 no 205 0.0127964849889768 69 NA FT OXIDATION-REDUCTION PROCESS NUCLEUS Protein of unknown function; similar to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress biological_process alcohol dehydrogenase (NADP+) activity nucleus|cytoplasm
YER098W YER098W UBP9 hom Verified 1.99487366249644 0.0230283303512726 no 206 0.0299880899411716 198 NA FT PROTEOLYSIS Ubiquitin-specific protease that cleaves ubiquitin-protein fusions; UBP9 has a paralog, UBP13, that arose from the whole genome duplication protein deubiquitination ubiquitin-specific protease activity cytoplasm
YIR020W-A_d YIR020W-A YIR020W-A hom Dubious 1.99455449201907 0.0230457455745779 no 207 0.027816760827379 156 NA Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data Unknown Unknown Unknown
YDL178W YDL178W DLD2 hom Verified 1.99422948194266 0.0230634908262236 no 208 0.0429459868209658 211 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION D-lactate dehydrogenase, located in the mitochondrial matrix lactate metabolic process actin binding|D-lactate dehydrogenase (cytochrome) activity mitochondrion|mitochondrial matrix
YBL062W_d YBL062W YBL062W hom Dubious 1.99352335456865 0.0231020843923008 no 209 0.033210937725572 187 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR310C YDR310C SUM1 hom Verified 1.98680818004127 0.0234718288966618 no 210 0.0300864776614265 180 NA FT TRANSCRIPTION FROM RNA POL II|GENE SILENCING NUCLEUS Transcriptional repressor required for mitotic repression of middle sporulation-specific genes; also acts as general replication initiation factor; involved in telomere maintenance, chromatin silencing; regulated by pachytene checkpoint negative regulation of transcription by competitive promoter binding|negative regulation of transcription from RNA polymerase II promoter during mitosis|DNA replication initiation|chromatin silencing at silent mating-type cassette DNA replication origin binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding nucleus
YPL222W_p YPL222W FMP40 hom Uncharacterized 1.98166176210951 0.0237585547952954 no 211 0.0235217841345797 151 NA FT MITOCHONDRION Putative protein of unknown function; proposed to be involved in responding to environmental stresses; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YOR238W_p YOR238W YOR238W hom Uncharacterized 1.97871641158155 0.0239239720712412 no 212 0.0110117991890387 86 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm biological_process molecular_function cytoplasm
YER060W YER060W FCY21 hom Verified 1.97489141638575 0.0241402358525705 no 213 0.0188239717697297 128 NA Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function transmembrane transport nucleobase transmembrane transporter activity integral to membrane
YOR123C YOR123C LEO1 hom Verified 1.97258434551473 0.0242714689977198 no 214 0.0221703902891413 208 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS RNA POL II, HOLOENZYME Component of the Paf1 complex; which associates with RNA polymerase II and is involved in histone methylation; plays a role in regulating Ty1 transposition; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay chromatin organization|Unknown|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription-coupled nucleotide-excision repair|histone H3-K4 trimethylation|transcription elongation from RNA polymerase II promoter RNA binding|RNA polymerase II transcription factor binding transcription factor activity nucleus|Cdc73/Paf1 complex
YKL208W YKL208W CBT1 hom Verified 1.96616807198446 0.0246395996320249 no 215 0.0239719923386644 152 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS MITOCHONDRION Protein involved in 5' end processing of mitochondrial COB, 15S_rRNA, and RPM1 transcripts; may also have a role in 3' end processing of the COB pre-mRNA; displays genetic interaction with cell cycle-regulated kinase Dbf2p cytochrome complex assembly|mRNA processing|mRNA stabilization molecular_function mitochondrion
YDR368W YDR368W YPR1 hom Verified 1.95562743447842 0.0252545293264128 no 216 0.0229050400353113 140 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS NUCLEUS NADPH-dependent aldo-keto reductase; reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases; protein abundance increases in response to DNA replication stress; YPR1 has a paralog, GCY1, that arose from the whole genome duplication cellular response to oxidative stress|D-xylose catabolic process|arabinose catabolic process glucose 1-dehydrogenase (NADP+) activity|alditol:NADP+ 1-oxidoreductase activity|carbonyl reductase (NADPH) activity nucleus|cytoplasm
YOL122C YOL122C SMF1 hom Verified 1.95538865164093 0.0252686072818445 no 217 0.0201414742937757 150 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Divalent metal ion transporter with a broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins copper ion transport|cellular copper ion homeostasis|manganese ion transport|cadmium ion transport|cellular manganese ion homeostasis|cellular cadmium ion homeostasis|iron ion transport solute:hydrogen symporter activity|inorganic cation transmembrane transporter activity integral to membrane|plasma membrane
YLR417W YLR417W VPS36 hom Verified 1.94775341733473 0.0257222375338432 no 218 0.0612919688953188 366 NA FF|FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome negative regulation of transcription from RNA polymerase II promoter by glucose|protein retention in Golgi apparatus|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein targeting to vacuole ubiquitin binding ESCRT II complex
YBR268W YBR268W MRPL37 hom Verified 1.94769470669324 0.0257257519308175 no 219 0.0525186340380197 255 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YMR071C YMR071C TVP18 hom Verified 1.94546301901496 0.0258596382125111 no 220 0.0470386397803071 283 NA FF|FT VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments vesicle-mediated transport molecular_function integral to membrane|integral to Golgi membrane|clathrin-coated vesicle
YML013W YML013W UBX2 hom Verified 1.93974091271407 0.0262055923802111 no 221 0.0506050560560719 324 NA FF|FT PROTEOLYSIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION UBIQUITIN LIGASE COMPLEX Bridging factor involved in ER-associated protein degradation (ERAD); bridges the cytosolic Cdc48p-Npl1p-Ufd1p ATPase complex and the membrane associated Ssm4p and Hrd1p ubiquitin ligase complexes; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain; redistributes from the ER to lipid droplets during the diauxic shift and stationary phase; required for the maintenance of lipid homeostasis proteasomal ubiquitin-dependent protein catabolic process|ER-associated protein catabolic process|lipid particle organization protein binding, bridging mitochondrial outer membrane|Doa10p ubiquitin ligase complex|integral to endoplasmic reticulum membrane|lipid particle|endoplasmic reticulum
YHR038W YHR038W RRF1 hom Verified 1.93644906958273 0.0264063622896261 no 222 0.0352397110182072 198 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial ribosome recycling factor, essential for mitochondrial protein synthesis and for the maintenance of the respiratory function of mitochondria mitochondrial translation translation release factor activity mitochondrion
YPL119C YPL119C DBP1 hom Verified 1.93490033067909 0.0265012638110315 no 223 0.0173547385735473 111 NA FT TRANSLATION Putative ATP-dependent RNA helicase of the DEAD-box protein family; mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs; protein abundance increases in response to DNA replication stress translational initiation RNA helicase activity cytoplasm
YCR066W YCR066W RAD18 hom Verified 1.93435367876775 0.0265348287794868 no 224 0.0400366680241373 288 NA FF|FT RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME E3 ubiquitin ligase; forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; required for postreplication repair; SUMO-targeted ubiquitin ligase (STUbl) that contains a SUMO-interacting motif (SIM) which stimulates its ubiquitin ligase activity towards the sumoylated form of PCNA protein monoubiquitination|error-free translesion synthesis|error-free postreplication DNA repair|error-prone translesion synthesis ubiquitin-protein ligase activity|single-stranded DNA-dependent ATPase activity|single-stranded DNA binding nuclear chromatin|nucleus
YMR199W YMR199W CLN1 hom Verified 1.93305571943807 0.0266146670756486 no 225 0.0182716525659461 140 NA FT CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION NUCLEUS G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p) regulation of cyclin-dependent protein kinase activity cyclin-dependent protein kinase regulator activity nucleus|cytoplasm
YKR088C YKR088C TVP38 hom Verified 1.93188567280095 0.0266868092643662 no 226 0.0274460256854375 199 NA FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|CYTOSKELETON ORGANIZATION ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; required for asymmetric localization of Kar9p during mitosis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern vesicle-mediated transport|mitotic spindle elongation molecular_function integral to membrane|integral to Golgi membrane|cytoplasm
YHR142W YHR142W CHS7 hom Verified 1.92367684226163 0.0271975512559443 no 227 0.0971557897874527 402 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein of unknown function; may be involved in chitin biosynthesis by regulation of Chs3p export from the ER; relocalizes from bud neck to ER upon DNA replication stress protein folding|ER to Golgi vesicle-mediated transport|fungal-type cell wall chitin biosynthetic process unfolded protein binding integral to membrane|endoplasmic reticulum membrane
YLR262C-A YLR262C-A TMA7 hom Verified 1.91834798304634 0.0275334510113675 no 228 0.0248356934258114 187 NA FT TRANSLATION NUCLEUS Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin; protein abundance increases in response to DNA replication stress cytoplasmic translation molecular_function nucleus|cytoplasm
YBL057C YBL057C PTH2 hom Verified 1.91213565998086 0.0279293979977149 no 229 0.0349822471000711 180 NA FT PROTEOLYSIS MITOCHONDRION One of two (see also PTH1) mitochondrially-localized peptidyl-tRNA hydrolases; negatively regulates the ubiquitin-proteasome pathway via interactions with ubiquitin-like ubiquitin-associated proteins; dispensable for cell growth negative regulation of proteasomal ubiquitin-dependent protein catabolic process aminoacyl-tRNA hydrolase activity mitochondrial outer membrane|mitochondrion|cytoplasm
YIL167W YIL167W SDL1 hom pseudogene 1.91194582582753 0.0279415715089774 no 230 0.0290256365392439 154 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Open reading frame, unlikely to produce a functional protein in S288C; in closely related species and other S. cerevisiae strain backgrounds YIL167W and adjacent ORF, YIL168W, constitute a single ORF encoding L-serine dehydratase serine family amino acid metabolic process L-serine ammonia-lyase activity cellular_component
YJR099W YJR099W YUH1 hom Verified 1.90746168222239 0.0282304142179087 no 231 0.0185115892558083 88 NA FT PROTEOLYSIS Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p protein deubiquitination ubiquitin-specific protease activity cytoplasm
YJL098W YJL098W SAP185 hom Verified 1.90653765964185 0.0282902422429458 no 232 0.0251006997081783 167 NA FT CELL CYCLE|RNA PROCESSING MITOCHONDRION Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap190p; SAP185 has a paralog, SAP190, that arose from the whole genome duplication tRNA wobble uridine modification|G1/S transition of mitotic cell cycle protein serine/threonine phosphatase activity mitochondrion|cytoplasm
YCR049C_d YCR049C YCR049C hom Dubious 1.89939030663281 0.0287565885210716 no 233 0.0415573700785084 198 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YKL057C YKL057C NUP120 hom Verified 1.89131154225623 0.029291384415965 no 234 0.0532842842949935 287 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP160 double-strand break repair|protein export from nucleus|ribosomal large subunit export from nucleus|maintenance of chromatin silencing at telomere|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|telomere tethering at nuclear periphery|nuclear pore distribution|mRNA export from nucleus in response to heat stress|mRNA export from nucleus|positive regulation of transcription, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter structural constituent of nuclear pore integral to membrane|nuclear pore|nuclear pore outer ring
YPL029W YPL029W SUV3 hom Verified 1.88997340642302 0.0293807584265977 no 235 0.0715694839185865 313 NA FF|FT RNA PROCESSING|MITOCHONDRION ORGANIZATION MITOCHONDRION|CHROMOSOME ATP-dependent RNA helicase, component of the mitochondrial degradosome along with the RNase Dss1p; the degradosome associates with the ribosome and mediates RNA turnover; also required during splicing of the COX1 AI5_beta intron mitochondrial DNA replication|mitochondrial RNA catabolic process|Group I intron splicing exoribonuclease II activity|ATP-dependent RNA helicase activity mitochondrion|mitochondrial chromosome|mitochondrial degradosome
YOL076W YOL076W MDM20 hom Verified 1.88771880735547 0.0295318550680819 no 236 0.0479586554762388 333 NA FF|FT MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly mitochondrion inheritance|N-terminal peptidyl-methionine acetylation|cytoskeleton organization peptide alpha-N-acetyltransferase activity NatB complex
YOR126C YOR126C IAH1 hom Verified 1.8852344209455 0.0296990977775619 no 237 0.0148155544592317 106 NA FT KETONE METABOLISM|LIPID METABOLISM Isoamyl acetate-hydrolyzing esterase, required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate, which is particularly important in sake brewing acetate metabolic process hydrolase activity, acting on ester bonds cellular_component
YGL148W YGL148W ARO2 hom Verified 1.88159544571321 0.0299454825323922 no 238 0.0908856971606396 435 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM Bifunctional chorismate synthase and flavin reductase; catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids; protein abundance increases in response to DNA replication stress aromatic amino acid family biosynthetic process chorismate synthase activity|riboflavin reductase (NADPH) activity cytoplasm
YMR216C YMR216C SKY1 hom Verified 1.87806232564077 0.0301863197109925 no 239 0.07879023858514 380 NA FF|FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1 cellular cation homeostasis|cellular ion homeostasis|response to drug|protein phosphorylation|positive regulation of protein import into nucleus|regulation of cell size|mRNA splice site selection protein serine/threonine kinase activity|protein kinase activity cytoplasm
YBR301W YBR301W PAU24 hom Verified 1.87586781384924 0.0303367166289313 no 240 0.0223184260511783 117 NA FT CELL WALL ORG/BIOGENESIS Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth biological_process molecular_function fungal-type cell wall
YMR297W YMR297W PRC1 hom Verified 1.87460343110667 0.0304236504060319 no 241 0.0158094366558011 112 NA FT PROTEOLYSIS ENDOPLASMIC RETICULUM Vacuolar carboxypeptidase Y (proteinase C; CPY), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family vacuolar protein catabolic process|phytochelatin biosynthetic process serine-type carboxypeptidase activity fungal-type vacuole lumen|endoplasmic reticulum|fungal-type vacuole|cytoplasm
YLR439W YLR439W MRPL4 hom Verified 1.87297147095245 0.0305361623246775 no 242 0.0543493225386482 247 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit, homolog of prokaryotic L29 ribosomal protein; located at the ribosomal tunnel exit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YJL101C YJL101C GSH1 hom Verified 1.87088301027993 0.0306806492004137 no 243 0.0228499186267974 156 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|RESPONSE TO OXIDATIVE STRESS Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress response to cadmium ion|response to hydrogen peroxide|glutathione biosynthetic process glutamate-cysteine ligase activity intracellular
YDR152W YDR152W GIR2 hom Verified 1.87085865667276 0.030682337399964 no 244 0.0309171746047302 186 NA FT TRANSLATION Highly-acidic cytoplasmic RWD domain-containing protein of unknown function; forms a complex with Rbg2p; interacts with Rbg1p and Gcn1p; associates with translating ribosomes; putative intrinsically unstructured protein cytoplasmic translation molecular_function polysome|cytoplasm
YDL186W_p YDL186W YDL186W hom Uncharacterized 1.86539415628235 0.0310630879384249 no 245 0.027043047477507 123 NA Putative protein of unknown function; YDL186W is not an essential gene biological_process molecular_function cellular_component
YJR084W YJR084W YJR084W hom Verified 1.86200364609855 0.0313012881487965 no 246 0.019585778366469 118 NA FT RNA PROCESSING|SIGNALING NUCLEUS|CHROMOSOME Protein that forms a complex with Thp3p; may have a role in transcription elongation and/or mRNA splicing; identified as a COP9 signalosome component but phenotype and interactions suggest it may not be involved with the signalosome adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|mRNA splicing, via spliceosome molecular_function transcriptionally active chromatin
YBR213W YBR213W MET8 hom Verified 1.86196704305057 0.0313038679136949 no 247 0.0382343980996055 180 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM Bifunctional dehydrogenase and ferrochelatase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis siroheme biosynthetic process|sulfate assimilation precorrin-2 dehydrogenase activity|ferrochelatase activity cellular_component
YCR020C YCR020C PET18 hom Verified 1.85647755565405 0.0316927596266425 no 248 0.0263335014250804 153 NA Protein of unknown function, has weak similarity to proteins involved in thiamin metabolism; expression is induced in the absence of thiamin thiamine metabolic process molecular_function cytosol
YJR077C YJR077C MIR1 hom Verified 1.85462283257991 0.0318250526363763 no 249 0.0299280979466501 175 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated phosphate ion transmembrane transport inorganic phosphate transmembrane transporter activity mitochondrion|integral to membrane|integral to mitochondrial inner membrane
YEL017C-A YEL017C-A PMP2 hom Verified 1.85350066952371 0.0319053151359845 no 250 0.0410251918741282 201 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog, PMP1, that arose from the whole genome duplication cation transport molecular_function membrane
YPR059C_d YPR059C YPR059C hom Dubious 1.85094315595541 0.0320888656527533 no 251 0.0361206717328799 245 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YMC1/YPR058W Unknown Unknown Unknown
YML028W YML028W TSA1 hom Verified 1.84871656282182 0.0322493753991948 no 252 0.0264736580906833 183 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|TRANSLATION|OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS Thioredoxin peroxidase; acts as both a ribosome-associated and free cytoplasmic antioxidant; self-associates to form a high-molecular weight chaperone complex under oxidative stress; deletion results in mutator phenotype; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress protein folding|cellular response to oxidative stress|replicative cell aging|DNA protection|DNA damage checkpoint|cell redox homeostasis|response to hydroperoxide unfolded protein binding|ribosome binding|peroxiredoxin activity|thioredoxin peroxidase activity cytosol|polysome|cytoplasm
YJL192C YJL192C SOP4 hom Verified 1.84773310822223 0.0323204809580608 no 253 0.0586412933625827 307 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM ER-membrane protein; suppressor of pma1-7, deletion of SOP4 slows down the export of wild-type Pma1p and Pma1-7 from the ER ER to Golgi vesicle-mediated transport molecular_function integral to membrane|endoplasmic reticulum
YDR519W YDR519W FPR2 hom Verified 1.84029049756451 0.0328627998573133 no 254 0.0504615661640501 237 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase); binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking; relocalizes from nucleus to vacuole upon DNA replication stress biological_process FK506 binding|peptidyl-prolyl cis-trans isomerase activity endoplasmic reticulum membrane
YJL073W YJL073W JEM1 hom Verified 1.83796161120826 0.0330340311372339 no 255 0.0369604015243183 249 NA FT PROTEOLYSIS ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM DnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane; exhibits genetic interactions with KAR2 karyogamy involved in conjugation with cellular fusion|ER-associated protein catabolic process|protein folding in endoplasmic reticulum unfolded protein binding|chaperone binding endoplasmic reticulum|nuclear outer membrane-endoplasmic reticulum membrane network
YGL117W_p YGL117W YGL117W hom Uncharacterized 1.83644207628988 0.0331461507172276 no 256 0.0709958156575586 388 NA FF Putative protein of unknown function biological_process molecular_function cellular_component
YDR430C YDR430C CYM1 hom Verified 1.83517547498547 0.0332398468718177 no 257 0.0177458861007911 79 NA FT PROTEOLYSIS MITOCHONDRION Lysine-specific metalloprotease of the mitochondrial intermembrane space, member of the pitrilysin family; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology proteolysis|proteolysis involved in cellular protein catabolic process metalloendopeptidase activity mitochondrion|mitochondrial intermembrane space
YOR311C YOR311C DGK1 hom Verified 1.83494114307864 0.0332572053403839 no 258 0.0220229228956065 124 NA FT VESICLE-MEDIATED TRANSPORT|KETONE METABOLISM|LIPID METABOLISM ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Diacylglycerol kinase, localized to the endoplasmic reticulum (ER); overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation; contains a CTP transferase domain phosphatidic acid biosynthetic process diacylglycerol kinase activity integral to endoplasmic reticulum membrane|integral to membrane
YPL090C YPL090C RPS6A hom Verified 1.8323931817676 0.0334464315748676 no 259 0.0354244029302606 214 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; RPS6A has a paralog, RPS6B, that arose from the whole genome duplication cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome small-subunit processome|cytosolic small ribosomal subunit|90S preribosome
YDR380W YDR380W ARO10 hom Verified 1.8303872329485 0.0335960277158971 no 260 0.0231835206670807 128 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Phenylpyruvate decarboxylase, catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde, which is the first specific step in the Ehrlich pathway L-phenylalanine catabolic process|methionine catabolic process to 3-methylthiopropanol|tryptophan catabolic process|branched-chain amino acid catabolic process to alcohol via Ehrlich pathway|aromatic amino acid family catabolic process to alcohol via Ehrlich pathway|leucine catabolic process pyruvate decarboxylase activity|carboxy-lyase activity|phenylpyruvate decarboxylase activity cytoplasm
YBR146W YBR146W MRPS9 hom Verified 1.82768329992448 0.0337985479586935 no 261 0.0375943869045902 201 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YCR050C_p YCR050C YCR050C hom Uncharacterized 1.82547053985943 0.0339650264691569 no 262 0.0274761867169714 199 NA Non-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein biological_process molecular_function cellular_component
YOR279C YOR279C RFM1 hom Verified 1.82378159712716 0.0340925485596887 no 263 0.063003864610741 280 NA FT GENE SILENCING NUCLEUS DNA-binding protein required for vegetative repression of middle sporulation genes; specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p; involved in telomere maintenance chromatin silencing|chromatin silencing at silent mating-type cassette unfolded protein binding histone deacetylase complex|nucleus
YDR071C YDR071C PAA1 hom Verified 1.82227354760136 0.0342067449070616 no 264 0.0408611503529797 248 NA FT CHROMATIN ORGANIZATION Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication chromatin organization diamine N-acetyltransferase activity|aralkylamine N-acetyltransferase activity cytoplasm
YBL089W YBL089W AVT5 hom Verified 1.81770507163107 0.034554611090917 no 265 0.0482758088048422 193 NA Putative transporter; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; AVT5 has a paralog, AVT6, that arose from the whole genome duplication transport transporter activity integral to membrane
YDR221W YDR221W GTB1 hom Verified 1.81639188548082 0.0346551395321164 no 266 0.0289233737074927 162 NA FT CARBOHYDRATE METABOLISM ENDOPLASMIC RETICULUM Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p; involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER; relocalizes from ER to cytoplasm upon DNA replication stress polysaccharide biosynthetic process|protein N-linked glycosylation alpha-glucosidase activity glucosidase II complex|endoplasmic reticulum|endoplasmic reticulum lumen
YFR015C YFR015C GSY1 hom Verified 1.81196069279305 0.0349961351389008 no 267 0.0192274928154941 96 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Glycogen synthase; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase; GSY1 has a paralog, GSY2, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress glycogen biosynthetic process glycogen (starch) synthase activity mitochondrion|cytoplasm
YFR016C YFR016C YFR016C hom Verified 1.80361058214555 0.0356461879902821 no 268 0.0148984296151888 87 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and bud; interacts with Spa2p; YFL016C is not an essential gene biological_process molecular_function cellular bud|cytoplasm
YMR223W YMR223W UBP8 hom Verified 1.79771337668796 0.0361112202600213 no 269 0.0270916859053235 191 NA FT CHROMATIN ORGANIZATION|PROTEOLYSIS NUCLEUS HISTONE ACETYLTRANSFERASE Ubiquitin-specific protease that is a component of the SAGA (Spt-Ada-Gcn5-Acetyltransferase) acetylation complex; required for SAGA-mediated deubiquitination of histone H2B histone H3-K4 methylation|histone deubiquitination|histone H3-K79 methylation ubiquitin-specific protease activity|protein complex scaffold DUBm complex|SLIK (SAGA-like) complex|SAGA complex
YJL110C YJL110C GZF3 hom Verified 1.79727932173407 0.0361456436429426 no 270 0.0448240978615999 212 NA FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS NUCLEUS GATA zinc finger protein; negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p; GZF3 has a paralog, DAL80, that arose from the whole genome duplication maintenance of protein location in nucleus|nitrogen catabolite repression of transcription|negative regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding RNA polymerase II transcription factor activity|sequence-specific DNA binding nucleus
YBL043W YBL043W ECM13 hom Verified 1.79022682771759 0.0367087269630867 no 271 0.0182245268951043 73 NA FT CELL WALL ORG/BIOGENESIS Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; ECM13 has a paralog, YJR115W, that arose from the whole genome duplication fungal-type cell wall organization molecular_function cellular_component
YBL047C YBL047C EDE1 hom Verified 1.78660487931802 0.0370006862685953 no 272 0.018320888274888 193 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING SITE OF POLARIZED GROWTH|CYTOSKELETON Endocytic protein; involved in a network of interactions with other endocytic proteins, binds membranes in a ubiquitin-dependent manner, may also bind ubiquitinated membrane-associated proteins; interacts with Cmk2 and functions upstream of CMK2 in regulating non-apoptotic cell death endoplasmic reticulum unfolded protein response|endocytosis ubiquitin binding cellular bud neck|mating projection tip|actin cortical patch|cellular bud tip
YGR057C YGR057C LST7 hom Verified 1.78575530440687 0.037069443230277 no 273 0.0729554867938422 326 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface intracellular protein transport|vesicle-mediated transport|protein transport|Golgi to plasma membrane transport protein transporter activity vesicle coat
YPL141C YPL141C FRK1 hom Verified 1.785685630833 0.0370750866136696 no 274 0.0354138756148755 233 NA FT PROTEIN PHOSPHORYLATION Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; interacts with rRNA transcription and ribosome biogenesis factors and the long chain fatty acyl-CoA synthetase Faa3p; FRK1 has a paralog, KIN4, that arose from the whole genome duplication protein phosphorylation protein kinase activity cytoplasm
YGR041W YGR041W BUD9 hom Verified 1.78268582951768 0.0373187296681572 no 275 0.020622106131455 85 NA FT CELL CYCLE|CELL DIVISION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Protein involved in bud-site selection; mutant has increased aneuploidy tolerance; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the distal pole cellular bud site selection molecular_function plasma membrane|cellular bud neck
YAL030W YAL030W SNC1 hom Verified 1.7812843602004 0.0374330040806777 no 276 0.0275697407379274 199 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|GOLGI APPARATUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; proposed to be involved in endocytosis; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC1 has a paralog, SNC2, that arose from the whole genome duplication endocytosis|exocytosis|Golgi to plasma membrane transport|vesicle fusion SNAP receptor activity SNARE complex|trans-Golgi network|endosome|transport vesicle membrane|plasma membrane|cellular bud neck
YDL046W YDL046W NPC2 hom Verified 1.77832896588423 0.0376749208498731 no 277 0.0347638113045247 155 NA Functional homolog of human NPC2/He1, which is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes intracellular sterol transport molecular_function fungal-type vacuole lumen|fungal-type vacuole
YDL110C YDL110C TMA17 hom Verified 1.77581025907551 0.0378820981007006 no 278 0.024908601148995 130 NA FT NUCLEUS Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion biological_process molecular_function ribosome|nucleus|cytoplasm
YNR056C YNR056C BIO5 hom Verified 1.76806762055425 0.0385247998737269 no 279 0.0373321594610771 210 NA FT KETONE METABOLISM|COFACTOR METABOLISM PLASMA MEMBRANE Putative transmembrane protein involved in the biotin biosynthesis pathway; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis biotin biosynthetic process|vitamin transport transmembrane transporter activity integral to membrane|plasma membrane
YNL142W YNL142W MEP2 hom Verified 1.76741368891727 0.0385794860418137 no 280 0.0335488119428494 139 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation nitrogen utilization|ammonium transport|pseudohyphal growth ammonium transmembrane transporter activity integral to membrane|plasma membrane
YKL146W YKL146W AVT3 hom Verified 1.76730516804694 0.0385885674048993 no 281 0.0397807757112294 173 NA FT VACUOLAR TRANSPORT Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters amino acid export from vacuole transporter activity|L-glutamine transmembrane transporter activity|L-isoleucine transmembrane transporter activity|L-tyrosine transmembrane transporter activity fungal-type vacuole membrane|integral to membrane
YGR187C YGR187C HGH1 hom Verified 1.76336660346987 0.0389193393185825 no 282 0.0365191851241315 213 NA Nonessential protein of unknown function; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16); relative distribution to the nucleus increases upon DNA replication stress biological_process molecular_function cytoplasm
YMR073C YMR073C IRC21 hom Verified 1.76171130370379 0.0390590435178221 no 283 0.100621463137839 415 NA FF Putative protein of unknown function; may be involved in resistance to carboplatin and cisplatin; null mutant displays increase in spontaneous Rad52p foci; contains a lipid-binding domain and binds cardiolipin in a large-scale study response to drug molecular_function cytoplasm
YPL241C YPL241C CIN2 hom Verified 1.75701731315644 0.039457429112937 no 284 0.0402803933400882 285 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS CYTOSKELETON GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2 protein folding|tubulin complex assembly|tubulin complex biogenesis GTPase activator activity cellular_component
YLR213C YLR213C CRR1 hom Verified 1.75272965565555 0.0398242113866313 no 285 0.027646480390342 143 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation ascospore wall assembly hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds ascospore wall
YDR137W YDR137W RGP1 hom Verified 1.74916975052757 0.0401308406173867 no 286 0.114286636577901 417 NA FF|FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|CELL DIVISION ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p retrograde transport, endosome to Golgi guanyl-nucleotide exchange factor activity Golgi apparatus|Ric1p-Rgp1p complex|Golgi membrane|guanyl-nucleotide exchange factor complex
YKL183W YKL183W LOT5 hom Verified 1.7490545461022 0.0401407955978641 no 287 0.0300109640676885 184 NA FT NUCLEUS Protein of unknown function; gene expression increases in cultures shifted to a lower temperature; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus|cytoplasm
YCL001W-A_p YCL001W-A YCL001W-A hom Uncharacterized 1.74846507215702 0.0401917642909108 no 288 0.0592788310046185 278 NA Putative protein of unknown function; YCL001W-A gene has similarity to DOM34 and is present in a region duplicated between chromosomes XIV and III biological_process molecular_function cellular_component
YFR022W YFR022W ROG3 hom Verified 1.74838067919157 0.0401990656042516 no 289 0.0276644231879129 151 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION Protein that binds the ubiquitin ligase Rsp5p via its 2 PY motifs; mutation suppresses the temperature sensitivity of an mck1 rim11 double mutant; proposed to regulate the endocytosis of plasma membrane proteins; ROG3 has a paralog, ROD1, that arose from the whole genome duplication ubiquitin-dependent endocytosis ubiquitin protein ligase binding cellular_component
YNL219C YNL219C ALG9 hom Verified 1.74708156655121 0.040311595204279 no 290 0.0488071166115157 221 NA FT LIPID METABOLISM|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Mannosyltransferase, involved in N-linked glycosylation; catalyzes both the transfer of seventh mannose residue on B-arm and ninth mannose residue on the C-arm from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation dolichol-linked oligosaccharide biosynthetic process|protein glycosylation mannosyltransferase activity integral to membrane|endoplasmic reticulum
YNR041C YNR041C COQ2 hom Verified 1.74431127555053 0.0405524132791417 no 291 0.0393491646179468 199 NA FT KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM MITOCHONDRION Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis ubiquinone biosynthetic process 4-hydroxybenzoate octaprenyltransferase activity mitochondrion|integral to mitochondrial membrane|integral to membrane
YKL103C YKL103C APE1 hom Verified 1.73579135450634 0.0413003666690423 no 292 0.0246896770664548 157 NA Vacuolar aminopeptidase yscI; zinc metalloproteinase that belongs to the peptidase family M18; often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway; protein increases in abundance and relative distribution to cytoplasmic foci increases upon DNA replication stress vacuolar protein catabolic process metalloaminopeptidase activity fungal-type vacuole
YPL273W YPL273W SAM4 hom Verified 1.73414698613432 0.0414460032436391 no 293 0.0331020930319778 203 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM NUCLEUS S-adenosylmethionine-homocysteine methyltransferase, functions along with Mht1p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio homocysteine metabolic process|L-methionine biosynthetic process from S-adenosylmethionine|S-adenosylhomocysteine metabolic process homocysteine S-methyltransferase activity nucleus|cytoplasm
YML082W_p YML082W YML082W hom Uncharacterized 1.73323358647421 0.0415270798172022 no 294 0.0603302014591416 217 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Putative protein predicted to have carbon-sulfur lyase activity; transcriptionally regulated by Upc2p via an upstream sterol response element; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and the cytoplasm; YML082W is not an essential gene sulfur compound metabolic process carbon-sulfur lyase activity nucleus|cytoplasm
YPR008W YPR008W HAA1 hom Verified 1.73299435759172 0.0415483358385449 no 295 0.0353442746857448 166 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Transcriptional activator involved in adaptation to weak acid stress; activates transcription of TPO2, YRO2, and other genes encoding membrane stress proteins; HAA1 has a paralog, CUP2, that arose from the whole genome duplication; relocalizes from cytoplasm to nucleus upon DNA replication stress response to acid|positive regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding RNA polymerase II transcription factor activity nucleus
YNL257C YNL257C SIP3 hom Verified 1.73299336080393 0.0415484244238074 no 296 0.0569382445423004 289 NA FT TRANSCRIPTION FROM RNA POL II Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog, YSP1, that arose from the whole genome duplication positive regulation of transcription from RNA polymerase II promoter transcription cofactor activity integral to membrane
YDR067C_p YDR067C OCA6 hom Uncharacterized 1.73221859169851 0.0416173250205428 no 297 0.0559299544018449 229 NA Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying positive-strand RNA virus replication; null mutation confers sensitivity to tunicamycin and DTT biological_process molecular_function cytoplasm
YER048C YER048C CAJ1 hom Verified 1.72796673983082 0.0419970937849292 no 298 0.0357412621917471 205 NA FT NUCLEUS Nuclear type II J heat shock protein of the E. coli dnaJ family, contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly protein folding chaperone binding nucleus
YLR246W YLR246W ERF2 hom Verified 1.72364752626904 0.0423857466211161 no 299 0.027007156190373 157 NA FT PROTEIN LOCALIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Subunit of a palmitoyltransferase, composed of Erf2p and Shr5p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; mutants partially mislocalize Ras2p to the vacuole protein targeting to membrane|protein palmitoylation palmitoyltransferase activity endoplasmic reticulum palmitoyltransferase complex|integral to endoplasmic reticulum membrane|integral to membrane
YDR025W YDR025W RPS11A hom Verified 1.72342922133387 0.0424054671876628 no 300 0.0467363134233738 225 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11A has a paralog, RPS11B, that arose from the whole genome duplication cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal small subunit assembly structural constituent of ribosome cytosolic small ribosomal subunit|90S preribosome
YHR096C YHR096C HXT5 hom Verified 1.71638898616899 0.0430454355240553 no 301 0.0502127335313633 215 NA FT PLASMA MEMBRANE Hexose transporter with moderate affinity for glucose; induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs; HXT5 has a paralog, HXT3, that arose from the whole genome duplication glucose transport|hexose transport mannose transmembrane transporter activity|fructose transmembrane transporter activity|glucose transmembrane transporter activity integral to membrane|plasma membrane
YLR266C YLR266C PDR8 hom Verified 1.71034283968599 0.0436012471543389 no 302 0.0365326424286779 213 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Transcription factor; targets include ATP-binding cassette (ABC) transporters, major facilitator superfamily transporters, and other genes involved in the pleiotropic drug resistance (PDR) phenomenon; PDR8 has a paralog, YRR1, that arose from the whole genome duplication positive regulation of transcription from RNA polymerase II promoter in response to stress RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|sequence-specific DNA binding nucleus
YBR058C-A YBR058C-A TSC3 hom Verified 1.70056083788925 0.0445127416120735 no 303 0.188604513825107 786 NA FF|FT KETONE METABOLISM|LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis 3-keto-sphinganine metabolic process|sphingolipid biosynthetic process enzyme activator activity SPOTS complex
YJL053W YJL053W PEP8 hom Verified 1.69971331671329 0.0445924316280497 no 304 0.0536961996046114 290 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress protein retention in Golgi apparatus|retrograde transport, endosome to Golgi protein transporter activity endosome|retromer complex, inner shell|retromer complex
YDR295C YDR295C HDA2 hom Verified 1.6964089169426 0.044904233097286 no 305 0.0333128384549291 138 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex containing an Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance negative regulation of transcription from RNA polymerase II promoter|gene silencing by RNA|histone deacetylation|gene silencing involved in chronological cell aging histone deacetylase activity|chromatin binding|DNA binding nucleus|HDA1 complex
YHR009C_p YHR009C TDA3 hom Uncharacterized 1.69410627989572 0.0451225446111663 no 306 0.051806818650686 260 NA FT VESICLE-MEDIATED TRANSPORT|OXIDATION-REDUCTION PROCESS Putative oxidoreductase involved in late endosome to Golgi transport; physical and genetical interactions with Btn2p; null mutant is viable, has extended S phase, and sensitive to expression of top1-T722A allele; similar to human FOXRED1 retrograde transport, endosome to Golgi molecular_function late endosome|cytoplasm
YJR139C YJR139C HOM6 hom Verified 1.69365156750937 0.0451657564143587 no 307 0.06120897281926 340 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS NUCLEUS Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions threonine biosynthetic process|methionine biosynthetic process|homoserine biosynthetic process homoserine dehydrogenase activity nucleus|cytoplasm
YOR035C YOR035C SHE4 hom Verified 1.69172033076512 0.0453496550609777 no 308 0.126547766073251 539 NA FF|FT CYTOSKELETON ORGANIZATION|RNA LOCALIZATION Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization mating type switching|intracellular mRNA localization|actin cytoskeleton organization myosin binding cytoplasm
YGR174W-A_p YGR174W-A YGR174W-A hom Uncharacterized 1.69028614786511 0.0454866119512589 no 309 0.0284573283222393 152 NA Putative protein of unknown function; predicted to have a role in cell budding based on computational guilt by association analysis biological_process molecular_function cellular_component
YAR028W_p YAR028W YAR028W hom Uncharacterized 1.68494337652442 0.0459997483257333 no 310 0.057482759313045 242 NA Putative integral membrane protein, member of DUP240 gene family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS biological_process molecular_function cellular_component
YML116W YML116W ATR1 hom Verified 1.68310949074493 0.0461769487763066 no 311 0.021606731221482 104 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Multidrug efflux pump of the major facilitator superfamily; required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; ATR1 has a paralog, YMR279C, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress borate transport|drug transmembrane transport drug transmembrane transporter activity|borate transmembrane transporter activity integral to membrane|plasma membrane|vacuole
YEL053C YEL053C MAK10 hom Verified 1.67254987509624 0.047207970791564 no 312 0.0419591384831673 236 NA Non-catalytic subunit of N-terminal acetyltransferase of the NatC type, required for replication of dsRNA virus; expression is glucose-repressible N-terminal protein amino acid acetylation peptide alpha-N-acetyltransferase activity NatC complex|cytoplasm
YHR033W_p YHR033W YHR033W hom Uncharacterized 1.67209000414204 0.0472532877086411 no 313 0.0253580279286924 133 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YHR033W has a paralog, PRO1, that arose from the whole genome duplication biological_process molecular_function cytoplasm
YKL118W_d YKL118W YKL118W hom Dubious 1.67205414191044 0.0472568231341256 no 314 0.110784035470091 470 NA FF Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene VPH2 Unknown Unknown Unknown
YMR109W YMR109W MYO5 hom Verified 1.67155698318339 0.0473058566426201 no 315 0.0357422241795339 186 NA FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION SITE OF POLARIZED GROWTH|CYTOSKELETON One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization bipolar cellular bud site selection|endocytosis|exocytosis|fungal-type cell wall organization|response to salt stress|receptor-mediated endocytosis|actin cortical patch localization|response to osmotic stress microfilament motor activity mating projection tip|actin cortical patch
YMR054W YMR054W STV1 hom Verified 1.66749737206929 0.0477077732645643 no 316 0.0491272601376232 282 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Subunit a of the vacuolar-ATPase V0 domain, one of two isoforms (Stv1p and Vph1p); Stv1p is located in V-ATPase complexes of the Golgi and endosomes while Vph1p is located in V-ATPase complexes of the vacuole vacuolar acidification proton-transporting ATPase activity, rotational mechanism vacuolar proton-transporting V-type ATPase, V0 domain|late endosome|integral to membrane|Golgi apparatus
YPL095C YPL095C EEB1 hom Verified 1.66656855105941 0.047800113330752 no 317 0.0596003240108625 259 NA FT KETONE METABOLISM|LIPID METABOLISM Acyl-coenzymeA:ethanol O-acyltransferase; responsible for the major part of medium-chain fatty acid ethyl ester biosynthesis during fermentation; possesses short-chain esterase activity; may be involved in lipid metabolism and detoxification; EEB1 has a paralog, EHT1, that arose from the whole genome duplication medium-chain fatty acid catabolic process|medium-chain fatty acid biosynthetic process short-chain carboxylesterase activity|alcohol O-octanoyltransferase activity cellular_component
YHL005C_d YHL005C YHL005C hom Dubious 1.66389571851915 0.0480666353939073 no 318 0.0356354886096669 196 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YHL004W Unknown Unknown Unknown
YLL020C_d YLL020C YLL020C hom Dubious 1.66358420259067 0.0480977755013732 no 319 0.0369182940263332 208 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KNS1 Unknown Unknown Unknown
YJL062W-A YJL062W-A COA3 hom Verified 1.6607721567255 0.0483796075892313 no 320 0.0406025386177726 218 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly mitochondrial respiratory chain complex IV assembly|negative regulation of mitochondrial translation molecular_function mitochondrion|mitochondrial inner membrane|integral to mitochondrial inner membrane
YNL054W YNL054W VAC7 hom Verified 1.6551243183963 0.0489496414512985 no 321 0.0349539438477137 210 NA FT LIPID METABOLISM Integral vacuolar membrane protein involved in vacuole inheritance and morphology; activates Fab1p kinase activity under basal conditions and also after hyperosmotic shock positive regulation of phosphatidylinositol biosynthetic process|positive regulation of kinase activity molecular_function fungal-type vacuole membrane|integral to membrane|PAS complex|vacuolar membrane|cytoplasm
YMR233W YMR233W TRI1 hom Verified 1.65509071410457 0.0489530491077951 no 322 0.0585279863544112 285 NA FT NUCLEUS Non-essential sumoylated protein of unknown function; similar to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus; TRI1 has a paralog, UAF30, that arose from the whole genome duplication biological_process molecular_function nucleolus|nucleus|cytoplasm
YLR279W_d YLR279W YLR279W hom Dubious 1.65098735244227 0.049370578730307 no 323 0.0654157842498763 292 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPL096W YPL096W PNG1 hom Verified 1.64997412912554 0.0494741137731418 no 324 0.055182587024047 214 NA FT RESPONSE TO DNA DAMAGE|PROTEOLYSIS NUCLEUS|MITOCHONDRION Conserved peptide N-glycanase required for deglycosylation of misfolded glycoproteins during proteasome-dependent degradation; localizes to the cytoplasm and nucleus; activity is enhanced by interaction with Rad23p misfolded or incompletely synthesized protein catabolic process|protein deglycosylation peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity cytosol|mitochondrion|nucleus
YPL125W YPL125W KAP120 hom Verified 1.64942571321977 0.0495302252586663 no 325 0.0574208943828348 258 NA FT PROTEIN LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE Karyopherin responsible for the nuclear import of ribosome maturation factor Rfp1p protein import into nucleus|transcription factor import into nucleus protein transporter activity|structural constituent of nuclear pore integral to membrane|nucleus|nuclear pore|cytoplasm
YPL034W_p YPL034W YPL034W hom Uncharacterized 1.64733936828748 0.0497441551296514 no 326 0.0582929958285621 250 NA Putative protein of unknown function; YPL034W is not essential gene biological_process molecular_function cellular_component
YKR024C YKR024C DBP7 hom Verified 1.64728349703384 0.0497498941813693 no 327 0.048858196837483 278 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis; essential for growth under anaerobic conditions maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ATP-dependent RNA helicase activity nucleolus
YDR322W YDR322W MRPL35 hom Verified 1.64306431136703 0.0501848139453927 no 328 0.0667719720843312 279 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YMR263W YMR263W SAP30 hom Verified 1.64040777872451 0.050460204524618 no 329 0.0659001840702934 352 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Subunit of a histone deacetylase complex, along with Rpd3p and Sin3p, that is involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenance positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of transcription from RNA polymerase I promoter|negative regulation of chromatin silencing at telomere|negative regulation of chromatin silencing at rDNA|positive regulation of transcription from RNA polymerase II promoter histone deacetylase activity histone deacetylase complex|Rpd3L-Expanded complex|Rpd3L complex
YPR150W_d YPR150W YPR150W hom Dubious 1.63502984195694 0.0510213959798245 no 330 0.0371319659954116 175 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SUE1/YPR151C Unknown Unknown Unknown
YOL046C_d YOL046C YOL046C hom Dubious 1.63270681074449 0.051265337166303 no 331 0.0391404031127045 198 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data;almost completely overlaps the verified gene PSK2/YOL045W Unknown Unknown Unknown
YGR233C YGR233C PHO81 hom Verified 1.62480496836503 0.0521020610406574 no 332 0.0578185465591825 296 NA FT LIPID METABOLISM NUCLEUS Cyclin-dependent kinase (CDK) inhibitor; regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; inhibitory activity for Pho80p-Pho85p requires myo-D-inositol heptakisphosphate (IP7) generated by Vip1p; relative distribution to the nucleus increases upon DNA replication stress phosphate-containing compound metabolic process cyclin-dependent protein kinase inhibitor activity nucleus|cytoplasm
YEL007W YEL007W MIT1 hom Verified 1.62240354493268 0.0523584853180424 no 333 0.0381194599910843 183 NA FT NUCLEUS Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1 biological_process molecular_function nucleus|cytoplasm
YDR421W YDR421W ARO80 hom Verified 1.61915289545042 0.0527071850760256 no 334 0.0287935048561866 147 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Zinc finger transcriptional activator of the Zn2Cys6 family; activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids aromatic amino acid family catabolic process|positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|nucleic acid binding transcription factor activity nucleus
YLR137W YLR137W RKM5 hom Verified 1.61853234004283 0.0527739615396835 no 335 0.0371389984368869 189 NA Protein lysine methyltransferase; monomethylates Lys-46 of the ribosomal large subunit Rpl1a/Rpl1b; member of the seven beta-strand methyltransferase superfamily; orthologs only found among fungal species protein methylation S-adenosylmethionine-dependent methyltransferase activity cellular_component
YFR047C YFR047C BNA6 hom Verified 1.61356834018134 0.0533105443424741 no 336 0.0490828418903252 222 NA FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM NUCLEUS Quinolinate phosphoribosyl transferase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p de novo NAD biosynthetic process from tryptophan nicotinate-nucleotide diphosphorylase (carboxylating) activity nucleus|cytoplasm
YDR147W YDR147W EKI1 hom Verified 1.61002226247023 0.0536964981369427 no 337 0.0475812654851802 199 NA FT LIPID METABOLISM Ethanolamine kinase; primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; exhibits some choline kinase activity, thus contributing to phosphatidylcholine synthesis via the CDP-choline pathway; EKI1 has a paralog, CKI1, that arose from the whole genome duplication phosphatidylethanolamine biosynthetic process|phosphatidylcholine biosynthetic process ethanolamine kinase activity|choline kinase activity cytoplasm
YGL255W YGL255W ZRT1 hom Verified 1.60964649061731 0.0537375263642728 no 338 0.0325601313929168 144 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor high-affinity zinc ion transport high affinity zinc uptake transmembrane transporter activity integral to membrane|integral to plasma membrane
YOR349W YOR349W CIN1 hom Verified 1.6073396156991 0.0539899442286112 no 339 0.0538421771652104 372 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl protein folding|tubulin complex assembly|tubulin complex biogenesis beta-tubulin binding cellular_component
YKL055C YKL055C OAR1 hom Verified 1.60712762355601 0.0540131873847434 no 340 0.074957302299814 368 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase, may comprise a type II mitochondrial fatty acid synthase along with Mct1p fatty acid metabolic process|aerobic respiration 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity mitochondrion
YNL012W YNL012W SPO1 hom Verified 1.60648980276671 0.0540831668413999 no 341 0.0419735666408318 223 NA FT CELL CYCLE|LIPID METABOLISM|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Meiosis-specific prospore protein; required for meiotic spindle pole body duplication and separation; required to produce bending force necessary for proper prospore membrane assembly during sporulation; has similarity to phospholipase B meiosis|spore membrane bending pathway phospholipase activity endoplasmic reticulum|nucleus|prospore membrane
YGR210C_p YGR210C YGR210C hom Uncharacterized 1.60270387154738 0.0545000241871906 no 342 0.0439068548541365 234 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm biological_process molecular_function cytoplasm
YPR089W_p YPR089W YPR089W hom Uncharacterized 1.60241740374738 0.0545316694135844 no 343 0.0589766257325121 295 NA FT GOLGI APPARATUS Protein of unknown function; exhibits genetic interaction with ERG11 and protein-protein interaction with Hsp82p biological_process molecular_function cellular_component
YIL044C YIL044C AGE2 hom Verified 1.60115611843074 0.054671172639963 no 344 0.0569800007303073 275 NA FT VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM GOLGI APPARATUS ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in Trans-Golgi-Network (TGN) transport; contains C2C2H2 cysteine/histidine motif ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport ARF GTPase activator activity clathrin-coated vesicle
YGL229C YGL229C SAP4 hom Verified 1.59771866767987 0.055052801154974 no 345 0.0561103477631605 225 NA FT CELL CYCLE MITOCHONDRION Protein required for function of the Sit4p protein phosphatase, member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p G1/S transition of mitotic cell cycle protein serine/threonine phosphatase activity mitochondrion|cytoplasm
YGL071W YGL071W AFT1 hom Verified 1.59671450760637 0.0551646801450394 no 346 0.16506947136045 614 NA FF|FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|ION HOMEOSTASIS|ION HOMEOSTASIS|RESPONSE TO NUTRIENT LEVELS|CHROMOSOME SEGREGATION NUCLEUS Transcription factor involved in iron utilization and homeostasis; binds consensus site PyPuCACCCPu and activates transcription in response to changes in iron availability; in iron-replete conditions activity is negatively regulated by Grx3p, Grx4p, and Fra2p, which regulate Aft1p translocation from the nucleus to the cytoplasm; AFT1 has a paralog, AFT2, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress positive regulation of transcription from RNA polymerase II promoter in response to iron ion starvation|meiotic chromosome segregation|positive regulation of iron ion transport|establishment of mitotic sister chromatid cohesion|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding nucleus|cytoplasm
YGR077C YGR077C PEX8 hom Verified 1.5933730748221 0.0555382611300959 no 347 0.0135716468737605 99 NA FT PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p protein targeting to peroxisome|peroxisome organization peroxisome targeting sequence binding peroxisomal matrix|peroxisomal membrane|extrinsic to intraperoxisomal membrane
YPR028W YPR028W YOP1 hom Verified 1.59185136528408 0.0557090527901112 no 348 0.0559855019803836 275 NA FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Membrane protein that interacts with Yip1p to mediate membrane traffic; interacts with Sey1p to maintain ER morphology; overexpression leads to cell death and accumulation of internal cell membranes; mutants have reduced phosphatidylserine transfer between the ER and mitochondria; forms ER foci upon DNA replication stress vesicle-mediated transport|endoplasmic reticulum organization|endoplasmic reticulum inheritance|nuclear pore complex assembly protein binding integral to membrane|endoplasmic reticulum|endoplasmic reticulum tubular network
YML019W YML019W OST6 hom Verified 1.59152741428538 0.0557454654379543 no 349 0.0633258668315032 304 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p protein N-linked glycosylation via asparagine|protein complex assembly dolichyl-diphosphooligosaccharide-protein glycotransferase activity oligosaccharyltransferase complex|integral to membrane
YCR069W YCR069W CPR4 hom Verified 1.59142729156067 0.0557567232024233 no 350 0.0495813290689085 241 NA Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway biological_process peptidyl-prolyl cis-trans isomerase activity membrane
YLL057C YLL057C JLP1 hom Verified 1.58872036271162 0.0560617698020967 no 351 0.03528478742391 162 NA FT OXIDATION-REDUCTION PROCESS Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase, involved in sulfonate catabolism for use as a sulfur source; contains sequence that resembles a J domain (typified by the E. coli DnaJ protein); induced by sulphur starvation sulfur compound catabolic process sulfonate dioxygenase activity cellular_component
YBR133C YBR133C HSL7 hom Verified 1.58625853105598 0.0563403375823833 no 352 0.0730263182516535 344 NA FT CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION SITE OF POLARIZED GROWTH Protein arginine N-methyltransferase; exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p; relocalizes away from bud neck upon DNA replication stress G2/M transition of mitotic cell cycle|regulation of cell cycle protein-arginine omega-N symmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity cellular bud neck
YIL138C YIL138C TPM2 hom Verified 1.58588523882882 0.0563826724494573 no 353 0.0691992956957233 320 NA FT VESICLE-MEDIATED TRANSPORT|CELL DIVISION|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|RNA LOCALIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Minor isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p; TPM2 has a paralog, TPM1, that arose from the whole genome duplication vacuole inheritance|exocytosis|intracellular mRNA localization|budding cell apical bud growth|budding cell isotropic bud growth|mitochondrion inheritance|actin polymerization or depolymerization|vesicle-mediated transport|actin filament organization|establishment of cell polarity|actin filament bundle assembly actin lateral binding cellular bud neck contractile ring|actin filament bundle
YIL058W_d YIL058W YIL058W hom Dubious 1.58538426492952 0.0564395270250308 no 354 0.0604796504289632 223 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YKL171W YKL171W NNK1 hom Verified 1.58376040075335 0.0566241269241629 no 355 0.0334924336801121 148 NA FT PROTEOLYSIS|PROTEIN PHOSPHORYLATION Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm proteolysis|protein phosphorylation protein kinase activity cytoplasm
YDL124W YDL124W YDL124W hom Verified 1.58160649613535 0.0568697150589812 no 356 0.0366527408011018 211 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS NUCLEUS NADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress cellular response to oxidative stress|cellular ketone metabolic process|cellular amide metabolic process|cellular aromatic compound metabolic process alpha-keto amide reductase activity|aldo-keto reductase (NADP) activity|alditol:NADP+ 1-oxidoreductase activity|alpha-keto ester reductase activity nucleus|plasma membrane|cytoplasm
YLR405W YLR405W DUS4 hom Verified 1.58041920629185 0.0570054479996122 no 357 0.0489180998724736 201 NA FT RNA PROCESSING|OXIDATION-REDUCTION PROCESS Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p tRNA modification tRNA dihydrouridine synthase activity cellular_component
YJR052W YJR052W RAD7 hom Verified 1.578233865028 0.0572559464892666 no 358 0.0535422420836094 208 NA FT RESPONSE TO DNA DAMAGE|PROTEOLYSIS NUCLEUS UBIQUITIN LIGASE COMPLEX Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex nucleotide-excision repair, DNA damage recognition|protein ubiquitination involved in ubiquitin-dependent protein catabolic process damaged DNA binding|ubiquitin-protein ligase activity|DNA-dependent ATPase activity nucleotide-excision repair factor 4 complex|Cul3-RING ubiquitin ligase complex
YDR318W YDR318W MCM21 hom Verified 1.57208422614931 0.0579655095913061 no 359 0.0797756854162907 355 NA FT CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME KINETOCHORE Component of the kinetochore sub-complex COMA; COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) bridges kinetochore subunits in contact with centromeric DNA with subunits bound to microtubules during kinetochore assembly; involved in minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-O and fission yeast mal2 chromosome segregation|establishment of mitotic sister chromatid cohesion molecular_function COMA complex|condensed nuclear chromosome kinetochore
YDR162C YDR162C NBP2 hom Verified 1.57184942693196 0.0579927377687628 no 360 0.134494977322928 534 NA FF|FT PROTEIN PHOSPHORYLATION NUCLEUS Protein involved in the HOG (high osmolarity glycerol) pathway; negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex; interacts with Bck1p and down regulates the cell wall integrity pathway; found in the nucleus and cytoplasm, contains an SH3 domain and a Ptc1p binding domain (PBM) negative regulation of protein kinase activity|response to heat|hyperosmotic response molecular_function nucleus|cytoplasm
YOL150C_d YOL150C YOL150C hom Dubious 1.56889208046925 0.0583365437633155 no 361 0.0490615763225226 184 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YCL014W YCL014W BUD3 hom Verified 1.56642769482726 0.0586242617814823 no 362 0.0545792752400427 235 NA FT CELL CYCLE|SIGNALING|CELL DIVISION SITE OF POLARIZED GROWTH|CYTOSKELETON Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding cellular bud site selection|axial cellular bud site selection|cytokinesis molecular_function cellular bud neck contractile ring|cellular bud neck
YEL009C YEL009C GCN4 hom Verified 1.56232672369712 0.0591055197965721 no 363 0.171174493449382 696 NA FF|FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|PROTEIN COMPLEX ORG/BIOGENESIS|AMINO ACID METABOLISM|RIBOSOME BIOGENESIS|RESPONSE TO NUTRIENT LEVELS NUCLEUS Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels nitrogen catabolite activation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription initiation from RNA polymerase II promoter|negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to nutrient levels chromatin binding|TFIID-class binding transcription factor activity|sequence-specific DNA binding|RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor recruiting transcription factor activity|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription|sequence-specific DNA binding transcription factor activity nucleus
YOR304C-A_p YOR304C-A YOR304C-A hom Uncharacterized 1.56052355666721 0.0593181038139941 no 364 0.0717131155895129 313 NA FT SITE OF POLARIZED GROWTH Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck biological_process molecular_function cellular bud|mating projection tip|cellular bud neck|cytoplasm
YGR008C YGR008C STF2 hom Verified 1.56000156425016 0.0593797557674513 no 365 0.0573366280983083 199 NA FT MITOCHONDRION Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress cellular response to desiccation molecular_function cytoplasm
YBR271W YBR271W EFM2 hom Verified 1.55739718445954 0.059688107106059 no 366 0.0753498766647288 289 NA S-adenosylmethionine-dependent methyltransferase; methylates translation elongation factors EF2 (Eft1p and Eft2p) and EF3A (Yef3p); belongs to the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; predicted to be involved in ribosome biogenesis peptidyl-lysine methylation S-adenosylmethionine-dependent methyltransferase activity|protein-lysine N-methyltransferase activity cytoplasm
YDL229W YDL229W SSB1 hom Verified 1.55736954158677 0.0596913866616603 no 367 0.0401830818207772 193 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RESPONSE TO NUTRIENT LEVELS Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in folding of newly-made polypeptide chains; member of the HSP70 family; interacts with phosphatase subunit Reg1p; SSB1 has a paralog, SSB2, that arose from the whole genome duplication cytoplasmic translation|cellular response to glucose starvation|translational termination|ribosomal subunit export from nucleus|regulation of translational fidelity|rRNA processing|'de novo' cotranslational protein folding unfolded protein binding|ATPase activity|calmodulin binding plasma membrane|polysome|cytoplasm
YBR144C_d YBR144C YBR144C hom Dubious 1.55515399911194 0.0599546984852331 no 368 0.0418227304809484 210 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR144C is not an essential gene Unknown Unknown Unknown
YMR012W YMR012W CLU1 hom Verified 1.55328937222323 0.0601770090623387 no 369 0.0523540899782796 234 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION eIF3 component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation, can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant translational initiation|mitochondrion organization molecular_function eukaryotic translation initiation factor 3 complex|cytoplasm
YPL152W YPL152W RRD2 hom Verified 1.55202609740124 0.0603279896444353 no 370 0.0557197052268573 325 NA FT CELL CYCLE|CYTOSKELETON ORGANIZATION Peptidyl-prolyl cis/trans-isomerase; also activates the phosphotyrosyl phosphatase activity of protein phosphatase 2A (PP2A); regulates G1 phase progression, the osmoresponse, microtubule dynamics; subunit of the Tap42p-Pph21p-Rrd2p complex; protein abundance increases in response to DNA replication stress mitotic spindle organization in nucleus|response to osmotic stress peptidyl-prolyl cis-trans isomerase activity|protein phosphatase type 2A regulator activity protein phosphatase type 2A complex
YNL304W YNL304W YPT11 hom Verified 1.54630430065189 0.0610155469100935 no 371 0.0649552841149296 236 NA FT SIGNALING|MITOCHONDRION ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH Rab family GTPase that interacts with the C-terminal tail domain of Myo2p; mediates distribution of mitochondria and endoplasmic reticuli to daughter cells mitochondrion inheritance|endoplasmic reticulum inheritance|Golgi inheritance|Golgi localization GTPase activity incipient cellular bud site|endoplasmic reticulum|cellular bud neck|cellular bud tip
YML026C YML026C RPS18B hom Verified 1.54618435208939 0.0610300257564785 no 372 0.0793420480215894 335 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION MITOCHONDRION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18B has a paralog, RPS18A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress cytoplasmic translation|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA export from nucleus structural constituent of ribosome cytosolic small ribosomal subunit|mitochondrion
YJL116C YJL116C NCA3 hom Verified 1.54534863041987 0.0611309792661854 no 373 0.0487826928646802 176 NA FT MITOCHONDRION ORGANIZATION MITOCHONDRION Protein involved in mitochondrion organization; functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; member of the SUN family; expression induced in cells treated with the mycotoxin patulin; NCA3 has a paralog, UTH1, that arose from the whole genome duplication mitochondrion organization molecular_function cellular_component
YDR389W YDR389W SAC7 hom Verified 1.54432107828622 0.0612552843438317 no 374 0.114243888446902 451 NA FF|FT CELL CYCLE|SIGNALING|CYTOSKELETON ORGANIZATION CYTOSKELETON GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate actin filament reorganization involved in cell cycle|small GTPase mediated signal transduction Rho GTPase activator activity intracellular
YFL054C_p YFL054C YFL054C hom Uncharacterized 1.54382002752356 0.0613159690654807 no 375 0.0543113958901887 210 NA Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol water transport|transmembrane transport water channel activity|glycerol transmembrane transporter activity|transporter activity integral to membrane
YBR299W YBR299W MAL32 hom Verified 1.53882862493595 0.0619230698318543 no 376 0.0663419671179157 294 NA FT CARBOHYDRATE METABOLISM Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose sucrose catabolic process|maltose catabolic process sucrose alpha-glucosidase activity|alpha-glucosidase activity|maltose alpha-glucosidase activity plasma membrane
YHL017W_p YHL017W YHL017W hom Uncharacterized 1.53873388265733 0.0619346384713146 no 377 0.045334125637521 193 NA FT GOLGI APPARATUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein co-localizes with clathrin-coated vesicles; YHL017W has a paralog, PTM1, that arose from the whole genome duplication biological_process molecular_function integral to membrane|clathrin-coated vesicle
YJL123C YJL123C MTC1 hom Verified 1.5383417117731 0.061982542991773 no 378 0.0654429928600173 323 NA FT GOLGI APPARATUS Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to COPI-coated vesicles (early Golgi); mtc1 is synthetically lethal with cdc13-1 biological_process molecular_function COPI-coated vesicle|ribosome|Golgi apparatus|cytoplasm
YAL049C YAL049C AIM2 hom Verified 1.53626601791491 0.0622365751563922 no 379 0.0533798076876289 244 NA Cytoplasmic protein involved in mitochondrial function or organization; null mutant displays reduced frequency of mitochondrial genome loss; potential Hsp82p interactor biological_process molecular_function cytoplasm
YLL026W YLL026W HSP104 hom Verified 1.53415465152774 0.0624958054747605 no 380 0.0642135110687681 225 NA FT PROTEIN LOCALIZATION|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS NUCLEUS Disaggregase; heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress trehalose metabolism in response to heat stress|protein folding in endoplasmic reticulum|protein unfolding|chaperone cofactor-dependent protein refolding|inheritance of oxidatively modified proteins involved in replicative cell aging|cellular heat acclimation ADP binding|unfolded protein binding|ATPase activity, coupled|chaperone binding|ATP binding TRC complex|nucleus|cytoplasm
YDR281C YDR281C PHM6 hom Verified 1.53342580055966 0.0625854878752546 no 381 0.080873118971154 331 NA Protein of unknown function, expression is regulated by phosphate levels biological_process molecular_function fungal-type vacuole
YDL096C_d YDL096C OPI6 hom Dubious 1.53239842411702 0.0627120730554448 no 382 0.0503393898768521 220 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PMT1/YDL095W; YDL096C is not essential Unknown Unknown Unknown
YMR291W YMR291W TDA1 hom Verified 1.5311152955232 0.062870450109631 no 383 0.059259975987253 253 NA FT PROTEIN PHOSPHORYLATION NUCLEUS Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; relocalizes from nucleus to cytoplasm upon DNA replication stress protein phosphorylation protein kinase activity nucleus|cytoplasm
YER174C YER174C GRX4 hom Verified 1.53099954524332 0.0628847525212277 no 384 0.0635486306609103 306 NA FT ION HOMEOSTASIS|CYTOSKELETON ORGANIZATION|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS NUCLEUS Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx3p and Grx5p; protects cells from oxidative damage; mutant has increased aneuploidy tolerance; transcription is regulated by Yap5 cellular iron ion homeostasis|cellular response to oxidative stress|actin cytoskeleton organization disulfide oxidoreductase activity nucleus
YOL131W_p YOL131W YOL131W hom Uncharacterized 1.52964702362381 0.0630520616023659 no 385 0.0618571876123266 282 NA Putative protein of unknown function biological_process molecular_function cellular_component
YPR148C YPR148C YPR148C hom Verified 1.52903438438953 0.0631279600499779 no 386 0.059586313300738 230 NA Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern biological_process molecular_function ribosome|cytoplasm
YEL025C_p YEL025C YEL025C hom Uncharacterized 1.52614233907433 0.0634872098909835 no 387 0.0367396712476946 160 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus biological_process molecular_function nucleus|cytoplasm
YBR187W_p YBR187W GDT1 hom Uncharacterized 1.52298527610409 0.0638811945805788 no 388 0.0682656681967025 333 NA Putative protein of unknown function; expression is reduced in a gcr1 null mutant; GFP-fusion protein localizes to the vacuole; expression pattern and physical interactions suggest a possible role in ribosome biogenesis biological_process molecular_function integral to membrane|fungal-type vacuole
YJR019C YJR019C TES1 hom Verified 1.52212806358977 0.0639884977259782 no 389 0.059658167843885 219 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM MITOCHONDRION Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids fatty acid beta-oxidation|fatty acid oxidation acyl-CoA hydrolase activity mitochondrion|peroxisome
YDR492W YDR492W IZH1 hom Verified 1.52180462509369 0.0640290211294793 no 390 0.0603325493120863 294 NA FT LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc response to zinc ion|cellular zinc ion homeostasis|cellular lipid metabolic process metal ion binding integral to membrane|endoplasmic reticulum|membrane
YBL095W_p YBL095W YBL095W hom Uncharacterized 1.51893228614806 0.0643897706028043 no 391 0.0626106087771158 299 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YJL169W_d YJL169W YJL169W hom Dubious 1.51868003703534 0.0644215269473557 no 392 0.0587075923249984 266 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2 Unknown Unknown Unknown
YOR235W_d YOR235W IRC13 hom Dubious 1.51719417055081 0.06460883384464 no 393 0.0991689590227415 388 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays increased levels of spontaneous Rad52 foci Unknown Unknown Unknown
YDL213C YDL213C NOP6 hom Verified 1.51590855792191 0.0647712380258652 no 394 0.0707603091575607 314 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS rRNA-binding protein required for 40S ribosomal subunit biogenesis; contains an RNA recognition motif (RRM); hydrophilin essential to overcome the stress of the desiccation-rehydration process; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes ribosomal small subunit biogenesis RNA binding|rRNA binding nucleolus|90S preribosome
YOL071W YOL071W EMI5 hom Verified 1.51522815386484 0.0648573178104919 no 395 0.0421404585910269 169 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Subunit of succinate dehydrogenase, which couples succinate oxidation to ubiquinone reduction; required for FAD cofactor attachment to Sdh1p; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma) protein-FAD linkage|cellular respiration|mitochondrial electron transport, succinate to ubiquinone|ascospore formation|tricarboxylic acid cycle|positive regulation of transcription from RNA polymerase II promoter succinate dehydrogenase (ubiquinone) activity mitochondrial respiratory chain complex II|mitochondrion|mitochondrial matrix
YJL122W YJL122W ALB1 hom Verified 1.51419896559655 0.0649876919901835 no 396 0.0461806280503179 210 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS NUCLEUS Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p ribosomal large subunit biogenesis molecular_function ribosome|nucleus|cytoplasm
YKR007W YKR007W MEH1 hom Verified 1.51093438634483 0.0654025843991933 no 397 0.0765635021028649 377 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; loss results in a defect in vacuolar acidification microautophagy|vacuolar acidification molecular_function fungal-type vacuole membrane|EGO complex|late endosome membrane
YOL164W-A_p YOL164W-A YOL164W-A hom Uncharacterized 1.50671668537689 0.0659416464187496 no 398 0.0463127889377422 225 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YBR119W YBR119W MUD1 hom Verified 1.50449728162763 0.0662266863812671 no 399 0.0842110476796509 309 NA FT RNA PROCESSING NUCLEUS U1 snRNP A protein, homolog of human U1-A; involved in nuclear mRNA splicing mRNA splicing, via spliceosome U1 snRNA binding|RNA binding U1 snRNP|U2-type prespliceosome
YCR101C_p YCR101C YCR101C hom Uncharacterized 1.50411080500188 0.0662764193235817 no 400 0.0670851182480754 340 NA Putative protein of unknown function; localizes to the membrane fraction; YCR101C is not an essential gene biological_process molecular_function integral to membrane|membrane
YDR109C_p YDR109C YDR109C hom Uncharacterized 1.50196218961108 0.0665534369845766 no 401 0.0508697082097745 227 NA FT CARBOHYDRATE METABOLISM Putative kinase biological_process molecular_function cellular_component
YBR073W YBR073W RDH54 hom Verified 1.50069946993841 0.0667166551206183 no 402 0.0774285316449612 317 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS DNA-dependent ATPase; stimulates strand exchange by modifying the topology of double-stranded DNA; involved in recombinational repair of DNA double-strand breaks during mitosis and meiosis; proposed to be involved in crossover interference; interacts with Dmc1p; stimulates Dmc1p and Rad51p DNA geometric change|heteroduplex formation|meiotic sister chromatid segregation|reciprocal meiotic recombination|double-strand break repair via break-induced replication DNA-dependent ATPase activity|DNA translocase activity nucleus
YOR267C YOR267C HRK1 hom Verified 1.49782124562269 0.0670898496884532 no 403 0.0363096409850551 169 NA FT ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS Protein kinase; implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis; protein abundance increases in response to DNA replication stress protein phosphorylation|cellular ion homeostasis protein serine/threonine kinase activity|protein kinase activity cytoplasm
YDR357C_p YDR357C CNL1 hom Uncharacterized 1.49533576251129 0.0674134180813857 no 404 0.0545276522307756 236 NA Protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm biological_process molecular_function BLOC-1 complex|cytoplasm
YLR016C YLR016C PML1 hom Verified 1.49414985281415 0.0675682281411437 no 405 0.0364904281841814 181 NA FT RNA PROCESSING|RNA LOCALIZATION NUCLEUS Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p mRNA export from nucleus|mRNA splicing, via spliceosome|maintenance of RNA location molecular_function RES complex|nucleus|cytoplasm
YEL054C YEL054C RPL12A hom Verified 1.49356117359837 0.0676451769782274 no 406 0.0633328767889617 278 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication cytoplasmic translation|ribosomal large subunit assembly structural constituent of ribosome cytosolic large ribosomal subunit
YJR005C-A_p YJR005C-A YJR005C-A hom Uncharacterized 1.4925560718299 0.0677767146871833 no 407 0.0581290675153071 238 NA Putative protein of unknown function; originally identified as a syntenic homolog of an Ashbya gossypii gene; YJR005C-A has a paralog, YGR169C-A, that arose from the whole genome duplication biological_process molecular_function cellular_component
YDR254W YDR254W CHL4 hom Verified 1.49065935473973 0.0680254762077153 no 408 0.0653362126363665 248 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME KINETOCHORE Outer kinetochore protein required for chromosome stability; involved in new kinetochore assembly and sister chromatid cohesion; peripheral component of the Ctf19 kinetochore complex that interacts with Ctf19p, Ctf3p, Iml3p and Mif2p; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-N and fission yeast mis15 kinetochore assembly|chromosome segregation|establishment of meiotic sister chromatid cohesion|protein localization to chromosome, centromeric region|maintenance of meiotic sister chromatid cohesion|establishment of mitotic sister chromatid cohesion structural molecule activity condensed nuclear chromosome outer kinetochore
YCR082W YCR082W AHC2 hom Verified 1.48739572761823 0.0684551623186772 no 409 0.0834058927281551 371 NA FT CHROMATIN ORGANIZATION NUCLEUS HISTONE ACETYLTRANSFERASE Component of the ADA histone acetyltransferase complex; Ach2p and Ach1p are unique to the ADA complex and not shared with the related SAGA and SLIK complexes; may tether Ach1p to the complex histone acetylation histone acetyltransferase activity Ada2/Gcn5/Ada3 transcription activator complex|nucleus|cytoplasm
YMR306C-A_d YMR306C-A YMR306C-A hom Dubious 1.48712837214066 0.0684904546754139 no 410 0.0551305672019547 276 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR479C YDR479C PEX29 hom Verified 1.48520876810218 0.0687442650310411 no 411 0.0735181414946006 287 NA FT PEROXISOME ORGANIZATION Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress peroxisome organization molecular_function integral to membrane|peroxisomal membrane
YGR015C_p YGR015C YGR015C hom Uncharacterized 1.48401245021742 0.0689028088312757 no 412 0.0795594072270825 286 NA FT MITOCHONDRION Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion biological_process molecular_function mitochondrion
YBR242W_p YBR242W YBR242W hom Uncharacterized 1.47900924357295 0.0695689221691581 no 413 0.102823089558837 355 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR242W is not an essential gene biological_process molecular_function nucleus|cytoplasm
YJR003C_p YJR003C YJR003C hom Uncharacterized 1.47786005717868 0.069722619688693 no 414 0.0710991123500566 281 NA FT MITOCHONDRION Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; predicted to be involved in ribosome biogenesis biological_process molecular_function mitochondrion
YPR119W YPR119W CLB2 hom Verified 1.47187275525773 0.0705276210135186 no 415 0.0854549720033767 411 NA FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome G2/M transition of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|positive regulation of spindle pole body separation cyclin-dependent protein kinase regulator activity nucleus|spindle pole body|cellular bud neck|spindle|cytoplasm
YDR197W YDR197W CBS2 hom Verified 1.47170303908663 0.0705505432879645 no 416 0.100114197995297 348 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial translational activator of the COB mRNA; interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader mitochondrial respiratory chain complex III biogenesis|positive regulation of mitochondrial translation translation regulator activity mitochondrion|extrinsic to mitochondrial inner membrane|mitochondrial ribosome
YLR181C YLR181C VTA1 hom Verified 1.46854646654486 0.0709779220428056 no 417 0.0629606963831294 289 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|VACUOLAR TRANSPORT Multivesicular body (MVB) protein involved in endosomal protein sorting; regulates Vps4p activity by promoting its oligomerization; has an N-terminal Vps60- and Did2- binding domain, a linker region, and a C-terminal Vps4p binding domain late endosome to vacuole transport via multivesicular body sorting pathway|positive regulation of protein oligomerization|late endosome to vacuole transport ATPase activator activity endosome|endosome membrane|multivesicular body
YDR078C YDR078C SHU2 hom Verified 1.46831413140604 0.0710094570601811 no 418 0.0702787699533526 309 NA FT RESPONSE TO DNA DAMAGE NUCLEUS Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function recombinational repair|maintenance of rDNA|error-free translesion synthesis molecular_function Shu complex
YDL225W YDL225W SHS1 hom Verified 1.46627923345442 0.071286115268296 no 419 0.0466347301006053 239 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins; undergoes sumoylation and phosphorylation during mitosis; protein abundance increases in response to DNA replication stress cytokinesis, actomyosin contractile ring assembly|G1 phase of mitotic cell cycle|barrier septum assembly|exit from mitosis|cell cycle cytokinesis|septin ring assembly|cellular bud neck septin ring organization GTP binding cellular bud neck septin ring|mating projection tip
YNL195C_p YNL195C YNL195C hom Uncharacterized 1.4653134521469 0.0714177090111426 no 420 0.0878603688471974 379 NA FT MITOCHONDRION Putative protein of unknown function; shares a promoter with YNL194C; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YCL028W YCL028W RNQ1 hom Verified 1.46475764220098 0.0714935260698506 no 421 0.0563814096005908 291 NA FT NUCLEUS [PIN(+)] prion, an infectious protein conformation that is generally an ordered protein aggregate biological_process molecular_function cytosol
YOL105C YOL105C WSC3 hom Verified 1.46339636281043 0.0716794766769695 no 422 0.0583672696725945 290 NA FT SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|PEROXISOME ORGANIZATION SITE OF POLARIZED GROWTH Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity; involved in the response to heat shock and other stressors; regulates 1,3-beta-glucan synthesis response to heat|peroxisome degradation|Rho protein signal transduction transmembrane signaling receptor activity mating projection tip
YLR286C YLR286C CTS1 hom Verified 1.46047910306226 0.0720792233043351 no 423 0.068844767611711 336 NA FT CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH Endochitinase, required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p cytokinesis, completion of separation|chitin catabolic process endochitinase activity nuclear envelope|extracellular region|fungal-type cell wall|endoplasmic reticulum|cellular bud neck
YLR312W-A YLR312W-A MRPL15 hom Verified 1.46031020717981 0.0721024190210825 no 424 0.0787669983042115 356 NA FT RNA PROCESSING|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YDR402C YDR402C DIT2 hom Verified 1.45971877145866 0.0721836903531573 no 425 0.0795545122899394 278 NA FT CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS N-formyltyrosine oxidase, sporulation-specific microsomal enzyme involved in the production of N,N-bisformyl dityrosine required for spore wall maturation, homologous to cytochrome P-450s ascospore wall assembly oxidoreductase activity cellular_component
YEL050C YEL050C RML2 hom Verified 1.45500166877146 0.0728343997554178 no 426 0.113176533547229 459 NA FF|FT KETONE METABOLISM|LIPID METABOLISM|TRANSLATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor cytoplasmic translation|fatty acid metabolic process structural constituent of ribosome mitochondrial large ribosomal subunit
YLR315W YLR315W NKP2 hom Verified 1.45105498859757 0.0733822744319081 no 427 0.104009755429132 344 NA FT CELL CYCLE|CELL DIVISION NUCLEUS|CHROMOSOME|CYTOSKELETON KINETOCHORE Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2 biological_process molecular_function spindle pole body|kinetochore
YDR136C_d YDR136C VPS61 hom Dubious 1.45074133242822 0.0734259507536682 no 428 0.183304550712335 601 NA FF Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 4% of ORF overlaps the verified gene RGP1; deletion causes a vacuolar protein sorting defect Unknown Unknown Unknown
YNL089C_d YNL089C YNL089C hom Dubious 1.44862546192541 0.0737211032880217 no 429 0.0712250838597482 335 NA Dubious open reading frame unlikely to encode a functional protein; almost completely overlaps YNL090W/RHO2 which encodes a small GTPase of the Rho/Rac subfamily of Ras-like proteins Unknown Unknown Unknown
YOR065W YOR065W CYT1 hom Verified 1.44858299202834 0.0737270368807417 no 430 0.060017391590885 229 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex oxidative phosphorylation|mitochondrial electron transport, ubiquinol to cytochrome c electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity mitochondrion|mitochondrial respiratory chain|integral to membrane|mitochondrial inner membrane|mitochondrial respiratory chain complex III
YGL026C YGL026C TRP5 hom Verified 1.4478631704881 0.0738276607767614 no 431 0.145080113947528 622 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis tryptophan biosynthetic process tryptophan synthase activity nucleus|cytoplasm
YHR184W YHR184W SSP1 hom Verified 1.44726425407199 0.0739114633054191 no 432 0.0728541927693527 340 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION Protein involved in the control of meiotic nuclear division and coordination of meiosis with spore formation; transcription is induced midway through meiosis ascospore wall assembly|protein complex assembly molecular_function prospore membrane
YDR392W YDR392W SPT3 hom Verified 1.44626114381581 0.0740519848848754 no 433 0.134170245286625 532 NA FF|FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS HISTONE ACETYLTRANSFERASE Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters conjugation with cellular fusion|histone acetylation|pseudohyphal growth|ascospore formation|chromatin modification|invasive growth in response to glucose limitation|transcription from RNA polymerase II promoter transcription cofactor activity SLIK (SAGA-like) complex|SAGA complex
YKL054C YKL054C DEF1 hom Verified 1.44333841672321 0.0744625814120234 no 434 0.0691055590089024 360 NA FT RESPONSE TO DNA DAMAGE|PROTEOLYSIS NUCLEUS|CHROMOSOME RNAPII degradation factor, forms a complex with Rad26p in chromatin, enables ubiquitination and proteolysis of RNAPII present in an elongation complex; mutant is deficient in Zip1p loading onto chromosomes during meiosis transcription-coupled nucleotide-excision repair|telomere maintenance|response to DNA damage stimulus|ubiquitin-dependent protein catabolic process molecular_function nucleus
YGR070W YGR070W ROM1 hom Verified 1.44303752471167 0.0745049504197954 no 435 0.0834022640952782 360 NA FT SIGNALING|NUCLEOTIDE METABOLISM GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP small GTPase mediated signal transduction|activation of Rho GTPase activity Rho guanyl-nucleotide exchange factor activity intracellular
YML113W YML113W DAT1 hom Verified 1.4419756704185 0.0746546186233187 no 436 0.0624679919917093 249 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS DNA binding protein that recognizes oligo(dA).oligo(dT) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; not essential for viability negative regulation of transcription from RNA polymerase II promoter AT DNA binding nucleus
YJR135C YJR135C MCM22 hom Verified 1.4392868264011 0.0750346368592021 no 437 0.0592740313393475 251 NA FT CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME KINETOCHORE Outer kinetochore protein and component of the Ctf3 subcomplex; binds to centromeric DNA in a Ctf19p-dependent manner; involved in chromosome segregation and minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-K and fission yeast sim4 chromosome segregation|establishment of mitotic sister chromatid cohesion molecular_function condensed nuclear chromosome kinetochore
YPR070W YPR070W MED1 hom Verified 1.4375758217523 0.0752772226079744 no 438 0.101021249370953 433 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter molecular_function core mediator complex
YOL055C YOL055C THI20 hom Verified 1.43449673935979 0.0757152794568591 no 439 0.0582711093051759 230 NA Trifunctional enzyme of thiamine biosynthesis, degradation and salvage; has hydroxymethylpyrimidine (HMP) kinase, HMP-phosphate (HMP-P) kinase and thiaminase activities; member of a gene family with THI21 and THI22; HMP and HMP-P kinase activity redundant with Thi21p thiamine biosynthetic process|thiamine catabolic process phosphomethylpyrimidine kinase activity|thiaminase activity|hydroxymethylpyrimidine kinase activity cytosol
YNR057C YNR057C BIO4 hom Verified 1.43352568622003 0.0758538318609192 no 440 0.0897180847570391 363 NA FT KETONE METABOLISM|COFACTOR METABOLISM Dethiobiotin synthetase, catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; expression appears to be repressed at low iron levels biotin biosynthetic process dethiobiotin synthase activity cytoplasm
YER180C YER180C ISC10 hom Verified 1.432487779734 0.0760021364710005 no 441 0.0741978550284991 331 NA FT CELL CYCLE Protein required for sporulation, transcript is induced 7.5 hours after induction of meiosis, expected to play significant role in the formation of reproductive cells sporulation resulting in formation of a cellular spore molecular_function cellular_component
YCR006C_d YCR006C YCR006C hom Dubious 1.43209839077086 0.0760578324793893 no 442 0.0822768805004497 330 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YIL055C_p YIL055C YIL055C hom Uncharacterized 1.42787050273051 0.0766645676187669 no 443 0.0765903941307057 293 NA Putative protein of unknown function biological_process molecular_function cellular_component
YJL133W YJL133W MRS3 hom Verified 1.42757176739622 0.0767075773183809 no 444 0.0671207193382026 275 NA FT RNA PROCESSING|ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Iron transporter, mediates Fe2+ transport across inner mito membrane; mitochondrial carrier family member; active under low-iron conditions; may transport other cations; MRS3 has a paralog, MRS4, that arose from the whole genome duplication mitochondrial iron ion transport|RNA splicing iron ion transmembrane transporter activity mitochondrion|integral to membrane
YMR021C YMR021C MAC1 hom Verified 1.42647883180372 0.0768650864562361 no 445 0.191227691147783 706 NA FF|FT TRANSCRIPTION FROM RNA POL II|ION HOMEOSTASIS|ION HOMEOSTASIS NUCLEUS Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport cellular copper ion homeostasis|positive regulation of protein catabolic process|positive regulation of transcription from RNA polymerase II promoter core promoter proximal region DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YKL128C YKL128C PMU1 hom Verified 1.41827835732452 0.0780547564071041 no 446 0.0494183620763259 222 NA FT NUCLEUS Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant biological_process molecular_function nucleus|cytoplasm
YDR346C YDR346C SVF1 hom Verified 1.41356764851123 0.0787444428664826 no 447 0.101842163807266 337 NA FT RESPONSE TO OXIDATIVE STRESS NUCLEUS Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis; mutant has increased aneuploidy tolerance cellular response to oxidative stress molecular_function nucleus|cytoplasm
YMR292W YMR292W GOT1 hom Verified 1.41266659165058 0.0788768895090848 no 448 0.063551235082784 292 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Homodimeric protein that is packaged into COPII vesicles and cycles between the ER and Golgi; involved in secretory transport but not directly required for aspects of transport assayed in vitro; may influence membrane composition ER to Golgi vesicle-mediated transport|Golgi to endosome transport molecular_function integral to membrane|endoplasmic reticulum|Golgi apparatus|ER to Golgi transport vesicle|Golgi membrane
YGL035C YGL035C MIG1 hom Verified 1.4092165925278 0.0793855664522382 no 449 0.0946538771364638 387 NA FT TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS ENDOMEMBRANE SYSTEM|NUCLEUS Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion negative regulation of transcription from RNA polymerase II promoter by glucose|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding nucleus|nuclear envelope lumen|cytoplasm
YJL044C YJL044C GYP6 hom Verified 1.40775595865682 0.079601672778693 no 450 0.0819464237534198 316 NA FT PROTEIN LOCALIZATION|SIGNALING|NUCLEOTIDE METABOLISM GTPase-activating protein (GAP) for the yeast Rab family member, Ypt6p; involved in vesicle mediated protein transport intracellular protein transport GTPase activator activity endosome|clathrin-coated vesicle
YAL065C_p YAL065C YAL065C hom Uncharacterized 1.40702512684876 0.0797099690546716 no 451 0.0742910576235546 281 NA Putative protein of unknown function; has homology to FLO1; possible pseudogene biological_process molecular_function cellular_component
YHR149C YHR149C SKG6 hom Verified 1.40521136477168 0.0799792178395224 no 452 0.0806307458235961 305 NA FT SITE OF POLARIZED GROWTH Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p biological_process molecular_function cell cortex|incipient cellular bud site|integral to membrane|cellular bud neck|cellular bud tip
YML104C YML104C MDM1 hom Verified 1.40120033635433 0.080577086881981 no 453 0.0462829898760339 192 NA FT MITOCHONDRION ORGANIZATION CYTOSKELETON Intermediate filament protein, required for nuclear and mitochondrial transmission to daughter buds; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P) nuclear migration|mitochondrion inheritance|mitochondrion organization structural constituent of cytoskeleton|phosphatidylinositol-3-phosphate binding intermediate filament|integral to membrane|cytoplasm
YPL170W YPL170W DAP1 hom Verified 1.40073910664351 0.0806460519145682 no 454 0.100334418301711 424 NA FT LIPID METABOLISM Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis regulation of ergosterol biosynthetic process heme binding endosome|membrane
YPR043W YPR043W RPL43A hom Verified 1.40056675981081 0.0806718333857842 no 455 0.0550591475174786 258 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L43A; null mutation confers a dominant lethal phenotype; homologous to mammalian ribosomal protein L37A, no bacterial homolog; RPL43A has a paralog, RPL43B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YBL046W YBL046W PSY4 hom Verified 1.39898019203683 0.0809094615233933 no 456 0.0762524469292174 364 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS Regulatory subunit of protein phosphatase PP4; presence of Psy4p in the PP4 complex (along with catalytic subunit Pph3p and Psy2p) is required for dephosphorylation of the histone variant H2AX, but not for dephosphorylation of Rad53p, during recovery from the DNA damage checkpoint; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; required for cisplatin resistance; homolog of mammalian R2 Unknown|protein dephosphorylation protein phosphatase regulator activity nucleus|cytoplasm
YOL112W YOL112W MSB4 hom Verified 1.39841580579664 0.0809941197488079 no 457 0.0831564659507289 367 NA FT SIGNALING|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH GTPase-activating protein of the Ras superfamily that acts primarily on Sec4p, localizes to the bud site and bud tip, has similarity to Msb3p; msb3 msb4 double mutation causes defects in secretion and actin organization actin filament organization Rab GTPase activator activity incipient cellular bud site|polarisome|cellular bud tip
YJL163C_p YJL163C YJL163C hom Uncharacterized 1.395609719743 0.0814160269456961 no 458 0.0747160132050746 315 NA Putative protein of unknown function biological_process molecular_function integral to membrane
YPL148C YPL148C PPT2 hom Verified 1.39481827273123 0.0815353236107398 no 459 0.13568332525512 506 NA FF|FT KETONE METABOLISM|LIPID METABOLISM MITOCHONDRION Phosphopantetheine:protein transferase (PPTase), activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation protein-cofactor linkage holo-[acyl-carrier-protein] synthase activity mitochondrion
YLR253W_p YLR253W YLR253W hom Uncharacterized 1.39119178784467 0.0820836384149432 no 460 0.0820709881047003 328 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; transcription is periodic during the metabolic cycle; YLR253W is not an essential gene biological_process molecular_function mitochondrion
YCR094W YCR094W CDC50 hom Verified 1.39006998685292 0.0822538130346285 no 461 0.13073200504136 602 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION GOLGI APPARATUS Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Lem3p; CDC50 has a paralog, YNR048W, that arose from the whole genome duplication intracellular protein transport|phospholipid translocation|endocytosis|actin cortical patch localization phospholipid-translocating ATPase activity trans-Golgi network|late endosome membrane
YIL077C_p YIL077C YIL077C hom Uncharacterized 1.38948998099384 0.0823419027231614 no 462 0.0993592555553331 371 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) biological_process molecular_function mitochondrion
YPL186C YPL186C UIP4 hom Verified 1.38895941242433 0.0824225462108049 no 463 0.108066288221077 357 NA FT ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION Protein that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope biological_process molecular_function mitochondrial outer membrane|nuclear envelope|endoplasmic reticulum
YNL250W YNL250W RAD50 hom Verified 1.38699500643829 0.0827216427605849 no 464 0.0556940734779527 273 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION Subunit of MRX complex with Mre11p and Xrs2p; complex is involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining; forms nuclear foci upon DNA replication stress base-excision repair|meiotic DNA double-strand break processing|telomere maintenance via recombination|meiosis|meiotic DNA double-strand break formation|double-strand break repair via nonhomologous end joining|telomere maintenance|double-strand break repair via break-induced replication|negative regulation of endodeoxyribonuclease activity double-stranded DNA binding|single-stranded telomeric DNA binding|ATPase activity|double-stranded telomeric DNA binding|G-quadruplex DNA binding|telomeric DNA binding|adenylate kinase activity mitochondrion|nucleus|Mre11 complex
YLR006C YLR006C SSK1 hom Verified 1.38534367667101 0.0829737022204791 no 465 0.0771145693803142 303 NA FT SIGNALING|PROTEIN PHOSPHORYLATION Cytoplasmic response regulator; part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism; required for mitophagy; dephosphorylated form is degraded by the ubiquitin-proteasome system; potential Cdc28p substrate activation of MAPKKK activity involved in osmosensory signaling pathway|positive regulation of protein autophosphorylation|osmosensory signaling pathway via two-component system protein kinase activator activity|two-component response regulator activity|protein homodimerization activity|mitogen-activated protein kinase kinase kinase binding cytoplasm
YGR169C YGR169C PUS6 hom Verified 1.38476760529546 0.0830617697132738 no 466 0.0478259685858924 228 NA FT RNA PROCESSING MITOCHONDRION tRNA:pseudouridine synthase, catalyzes the conversion of uridine to pseudouridine at position 31 in cytoplasmic and mitochondrial tRNAs; mutation of Asp168 to Ala abolishes enzyme activity; not essential for viability tRNA pseudouridine synthesis pseudouridine synthase activity mitochondrion|cytoplasm
YML068W YML068W ITT1 hom Verified 1.38300109073129 0.0833322657246659 no 467 0.0609262866583731 269 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION Protein that modulates the efficiency of translation termination, interacts with translation release factors eRF1 (Sup45p) and eRF3 (Sup35p) in vitro, contains a zinc finger domain characteristic of the TRIAD class of proteins regulation of translational termination molecular_function cellular_component
YPR078C_p YPR078C YPR078C hom Uncharacterized 1.38120662290107 0.0836077195019476 no 468 0.0649941129976921 308 NA Putative protein of unknown function; possible role in DNA metabolism and/or in genome stability; expression is heat-inducible biological_process molecular_function cellular_component
YOR384W YOR384W FRE5 hom Verified 1.3808761179801 0.0836585270733154 no 469 0.101223982295492 399 NA FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION|PLASMA MEMBRANE Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process ferric-chelate reductase activity mitochondrion|integral to membrane
YOL056W YOL056W GPM3 hom Verified 1.38007870973467 0.0837812058442823 no 470 0.0785936907117478 332 NA FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event biological_process phosphoglycerate mutase activity|molecular_function cytosol
YGL077C YGL077C HNM1 hom Verified 1.37722119977183 0.0842219346823103 no 471 0.0701655121138205 319 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Choline/ethanolamine transporter; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol choline transport|ethanolamine transport|glycine betaine transport choline transmembrane transporter activity|ethanolamine transmembrane transporter activity integral to membrane|plasma membrane
YGL082W_p YGL082W YGL082W hom Uncharacterized 1.37660041550983 0.0843179111864025 no 472 0.060100994930395 262 NA FT NUCLEUS Putative protein of unknown function; predicted prenylation/proteolysis target of Afc1p and Rce1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YGL082W is not an essential gene biological_process molecular_function nucleus|plasma membrane|cytoplasm
YOL160W_d YOL160W YOL160W hom Dubious 1.37536300922414 0.0845094655114768 no 473 0.0537302057880553 180 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDL156W YDL156W CMR1 hom Verified 1.37519293883467 0.0845358184324584 no 474 0.0952933376491161 354 NA FT NUCLEUS|CHROMOSOME DNA-binding protein with preference for UV-damaged DNA; protein sequence contains three WD domains (WD-40 repeat); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; potential regulatory target of Mbp1p, which binds to the promoter region; co-localizes with Hos2p in nuclear foci in response to DNA damage by MMS biological_process DNA binding nuclear chromatin|nucleus|cytoplasm
YBR280C YBR280C SAF1 hom Verified 1.3721581005347 0.0850071128618235 no 475 0.0841179259972551 308 NA FT PROTEOLYSIS UBIQUITIN LIGASE COMPLEX F-Box protein involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence; interacts with Skp1 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity SCF ubiquitin ligase complex
YHR182W YHR182W YHR182W hom Verified 1.37051993085644 0.0852623290709927 no 476 0.103183205395238 333 NA FT SIGNALING Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm; relocalizes from bud neck to cytoplasm upon DNA replication stress biological_process molecular_function cytoplasm
YFR040W YFR040W SAP155 hom Verified 1.36863983185826 0.0855559433069358 no 477 0.0951376389862517 419 NA FT CELL CYCLE Protein required for function of the Sit4p protein phosphatase; forms a complex with Sit4p; member of a family of similar proteins including Sap4p, Sap185p, and Sap190p; protein abundance increases in response to DNA replication stress G1/S transition of mitotic cell cycle protein serine/threonine phosphatase activity cytoplasm
YNR062C_p YNR062C YNR062C hom Uncharacterized 1.36749328094556 0.0857353709405957 no 478 0.0806391363243779 338 NA Putative membrane protein of unknown function biological_process molecular_function integral to membrane
YKR102W YKR102W FLO10 hom Verified 1.36706492022671 0.085802478791869 no 479 0.0661974086402261 225 NA Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth filamentous growth of a population of unicellular organisms|flocculation via cell wall protein-carbohydrate interaction|flocculation|invasive growth in response to glucose limitation mannose binding fungal-type cell wall
YIL045W YIL045W PIG2 hom Verified 1.36561106581024 0.0860305357272618 no 480 0.0830485042319753 333 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Putative type-1 protein phosphatase targeting subunit that tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase regulation of glycogen biosynthetic process protein phosphatase type 1 regulator activity cytoplasm
YNL293W YNL293W MSB3 hom Verified 1.36340967931358 0.0863767161281412 no 481 0.0878780079103876 330 NA FT VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH Rab GTPase-activating protein; regulates endocytosis via activation of Vps21p and Ypt7p; also acts on Ypt52p and Sec4p; also required for proper actin organization; localizes to the plasma membrane and sites of polarized growth, and a portion localizes to endosomes and vacuoles; similar to Msb4p; relocalizes from bud neck to cytoplasm upon DNA replication stress actin filament organization|exocytosis Rab GTPase activator activity incipient cellular bud site|polarisome|cellular bud tip
YBR085C-A YBR085C-A YBR085C-A hom Verified 1.36112423241474 0.0867372164635379 no 482 0.0638463784030369 296 NA FT NUCLEUS Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus|cytoplasm
YCL026C-B YCL026C-B HBN1 hom Verified 1.3600088658627 0.0869135591562755 no 483 0.0979701032498049 402 NA FT OXIDATION-REDUCTION PROCESS NUCLEUS Protein of unknown function; similar to bacterial nitroreductases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein becomes insoluble upon intracellular iron depletion; protein abundance increases in response to DNA replication stress biological_process NAD(P)H nitroreductase activity nucleus|cytoplasm
YCR060W YCR060W TAH1 hom Verified 1.35980519989794 0.0869457882353975 no 484 0.0740009677932728 282 NA FT PROTEIN COMPLEX ORG/BIOGENESIS NUCLEUS Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); contains a single TPR domain with at least two TPR motifs; R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II protein folding|box C/D snoRNP assembly chaperone binding R2TP complex|nucleus|cytoplasm
YLR090W YLR090W XDJ1 hom Verified 1.35802140929466 0.087228445426848 no 485 0.0963126890145554 350 NA FT NUCLEUS|MITOCHONDRION Chaperone with a role in facilitating mitochondrial protein import; ascomycete-specific member of the DnaJ-like family, closely related to Ydj1p; predicted to be C-terminally prenylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies protein folding chaperone binding mitochondrion|integral to mitochondrial outer membrane|nucleus
YMR068W YMR068W AVO2 hom Verified 1.3569966410145 0.0873911389044397 no 486 0.0925118156968898 350 NA FT SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION PLASMA MEMBRANE Component of a complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth fungal-type cell wall organization|TOR signaling cascade|regulation of cell growth|establishment or maintenance of actin cytoskeleton polarity molecular_function TORC2 complex|cytoplasm
YOL059W YOL059W GPD2 hom Verified 1.35599373799277 0.0875505802312416 no 487 0.11923267924744 424 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM MITOCHONDRION NAD-dependent glycerol 3-phosphate dehydrogenase, homolog of Gpd1p, expression is controlled by an oxygen-independent signaling pathway required to regulate metabolism under anoxic conditions; located in cytosol and mitochondria; constitutively active but is inactivated via phosphorylation by energy-stress responsive kinase SNF1 NADH oxidation|glycerol metabolic process glycerol-3-phosphate dehydrogenase [NAD+] activity cytosol|mitochondrion
YKR032W_d YKR032W YKR032W hom Dubious 1.3554630750621 0.087635032690019 no 488 0.0705148974012462 293 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YNR023W YNR023W SNF12 hom Verified 1.35466169162054 0.087762684202706 no 489 0.218775559196593 747 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS NUCLEUS RSC COMPLEX 73 kDa subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; homolog of Rsc6p subunit of the RSC chromatin remodeling complex; relocates to the cytosol under hypoxic conditions; deletion mutants are temperature-sensitive positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation|positive regulation of transcription from RNA polymerase II promoter molecular_function SWI/SNF complex
YOL100W YOL100W PKH2 hom Verified 1.35194816956822 0.0881959482385278 no 490 0.0911874037212779 373 NA FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION NUCLEUS Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh1p regulation of nuclear-transcribed mRNA poly(A) tail shortening|protein phosphorylation|MAPK cascade involved in cell wall biogenesis|cytoplasmic mRNA processing body assembly protein kinase activity cell cortex|eisosome|nucleus
YDL041W_d YDL041W YDL041W hom Dubious 1.35099541879577 0.0883484501062496 no 491 0.122381522472191 494 NA FF Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIR2/YDL042C Unknown Unknown Unknown
YLR282C_d YLR282C YLR282C hom Dubious 1.349027484486 0.0886640691212948 no 492 0.0754092079384027 300 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition Unknown Unknown Unknown
YKR059W YKR059W TIF1 hom Verified 1.34860439130825 0.0887320347208926 no 493 0.0871679036335664 331 NA FT TRANSLATION RIBOSOME Translation initiation factor eIF4A; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; protein abundance increases in response to DNA replication stress; TIF1 has a paralog, TIF2, that arose from the whole genome duplication translational initiation ATP-dependent RNA helicase activity|translation initiation factor activity ribosome|eukaryotic translation initiation factor 4F complex
YKL142W YKL142W MRP8 hom Verified 1.34802314637155 0.088825469039484 no 494 0.0894949749616146 365 NA Protein of unknown function; undergoes sumoylation; transcription induced under cell wall stress; protein levels are reduced under anaerobic conditions; protein abundance increases in response to DNA replication stress; originally thought to be a mitochondrial ribosomal protein based on sequence analysis biological_process molecular_function cytoplasm
YDR075W YDR075W PPH3 hom Verified 1.34662808395274 0.0890500222763191 no 495 0.068192510832646 303 NA FT CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Catalytic subunit of protein phosphatase PP4 complex; active complex is composed of Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; involved in activation of Gln3p to alleviate nitrogen catabolite repression; Pph3p and Psy2p localize to foci on meiotic chromosomes Unknown|signal transduction involved in meiotic recombination checkpoint|double-strand break repair via homologous recombination|protein dephosphorylation|positive regulation of nitrogen compound metabolic process protein serine/threonine phosphatase activity condensed nuclear chromosome|nucleus|cytoplasm
YFL003C YFL003C MSH4 hom Verified 1.34659956411366 0.0890546173143143 no 496 0.0535131008050055 197 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Protein involved in meiotic recombination, required for normal levels of crossing over, colocalizes with Zip2p to discrete foci on meiotic chromosomes, has homology to bacterial MutS protein reciprocal meiotic recombination DNA binding nuclear chromosome
YER084W_p YER084W YER084W hom Uncharacterized 1.34513779915006 0.0892903692538834 no 497 0.1007480912514 400 NA Protein of unknown function; expressed at both mRNA and protein levels biological_process molecular_function cellular_component
YOL007C YOL007C CSI2 hom Verified 1.34454785072867 0.0893856469246281 no 498 0.0834463116089827 350 NA FT SITE OF POLARIZED GROWTH Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene biological_process molecular_function fungal-type vacuole|cellular bud neck
YKR085C YKR085C MRPL20 hom Verified 1.34391077182361 0.0894886211561472 no 499 0.10286568058989 411 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YPL161C YPL161C BEM4 hom Verified 1.34242797628506 0.0897286343795241 no 500 0.174164765341864 589 NA FF|FT SIGNALING|CYTOSKELETON ORGANIZATION NUCLEUS Protein involved in establishment of cell polarity and bud emergence; interacts with the Rho1p small GTP-binding protein and with the Rho-type GTPase Cdc42p; involved in maintenance of proper telomere length establishment of cell polarity|Rho protein signal transduction|actin cytoskeleton organization molecular_function nucleus|cytoplasm
YOR300W_d YOR300W YOR300W hom Dubious 1.34137489368198 0.0898993823696841 no 501 0.0696895638134703 259 NA Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7 Unknown Unknown Unknown
YDR049W YDR049W VMS1 hom Verified 1.34133628688462 0.0899056467045447 no 502 0.0786668681068777 358 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans ER-associated protein catabolic process|mitochondria-associated protein catabolic process|nucleus-associated proteasomal ubiquitin-dependent protein catabolic process molecular_function cytosol|mitochondrion|endoplasmic reticulum membrane|Cdc48p-Npl4p-Vms1p AAA ATPase complex|cytoplasm
YBR157C YBR157C ICS2 hom Verified 1.34080884828529 0.0899912613293848 no 503 0.080144406192227 305 NA Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization biological_process molecular_function cellular_component
YLL042C YLL042C ATG10 hom Verified 1.33902521890019 0.0902812315677984 no 504 0.0681719715700687 253 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Conserved E2-like conjugating enzyme that mediates formation of the Atg12p-Atg5p conjugate, which is a critical step in autophagy piecemeal microautophagy of nucleus|cellular protein modification process|mitochondrion degradation|macroautophagy|CVT pathway Atg12 ligase activity cellular_component
YMR256C YMR256C COX7 hom Verified 1.33802431061337 0.0904442560489215 no 505 0.118316618249402 440 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain mitochondrial electron transport, cytochrome c to oxygen cytochrome-c oxidase activity mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YJR033C YJR033C RAV1 hom Verified 1.33601067899402 0.0907728914246625 no 506 0.12031964842551 513 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate early endosome to late endosome transport|vacuolar acidification|regulation of protein complex assembly molecular_function RAVE complex|cytoplasm|extrinsic to membrane
YOL126C YOL126C MDH2 hom Verified 1.33490762452944 0.0909532910138009 no 507 0.0875011603803528 385 NA FT PROTEIN LOCALIZATION|KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|PEROXISOME ORGANIZATION Cytoplasmic malate dehydrogenase, one of three isozymes that catalyze interconversion of malate and oxaloacetate; involved in the glyoxylate cycle and gluconeogenesis during growth on two-carbon compounds; interacts with Pck1p and Fbp1 protein import into peroxisome matrix|gluconeogenesis|malate metabolic process L-malate dehydrogenase activity cytosol|cytoplasm
YGR196C YGR196C FYV8 hom Verified 1.33482225664862 0.0909672636266619 no 508 0.0907438643833023 359 NA Protein of unknown function, required for survival upon exposure to K1 killer toxin biological_process molecular_function cytoplasm
YGR130C YGR130C YGR130C hom Verified 1.33355663913895 0.09117460077607 no 509 0.112654197565794 427 NA Component of the eisosome with unknown function; GFP-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7) biological_process molecular_function eisosome|membrane raft|cytoplasm
YPR066W YPR066W UBA3 hom Verified 1.33149011210661 0.0915138981888547 no 510 0.101960046247904 382 NA Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern protein neddylation NEDD8 activating enzyme activity cytoplasm
YLR428C_d YLR428C YLR428C hom Dubious 1.33093408794664 0.0916053498368681 no 511 0.0970589394509279 431 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CRN1 Unknown Unknown Unknown
YGL100W YGL100W SEH1 hom Verified 1.33092420552286 0.0916069758532293 no 512 0.111787162706915 470 NA FF|FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|PLASMA MEMBRANE NUCLEAR PORE Component of two distinct complexes; subunit of the Nup84 nuclear pore sub-complex (NPC) and the Seh1-associated (SEA) complex; the the NUP84 subcomplex contributes to nucleocytoplasmic transport and NPC biogenesis; the SEA complex is a coatamer-related complex that associates dynamically with the vacuole; homologous to human SEH1 nucleocytoplasmic transport structural constituent of nuclear pore fungal-type vacuole membrane|integral to membrane|nuclear pore|Seh1-associated complex|nuclear pore outer ring
YLR441C YLR441C RPS1A hom Verified 1.32812847334046 0.0920678342755798 no 513 0.112669847956848 400 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal protein 10 (rp10) of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1A has a paralog, RPS1B, that arose from the whole genome duplication cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit|90S preribosome
YOR298W YOR298W MUM3 hom Verified 1.32741807760932 0.0921852114813513 no 514 0.0938852150645372 315 NA FT LIPID METABOLISM|CELL WALL ORG/BIOGENESIS Protein of unknown function involved in the organization of the outer spore wall layers; has similarity to the tafazzins superfamily of acyltransferases ascospore wall assembly|phospholipid biosynthetic process transferase activity, transferring acyl groups cellular_component
YIR039C YIR039C YPS6 hom Verified 1.32679981408529 0.0922874559996497 no 515 0.109796134400592 444 NA FT CELL WALL ORG/BIOGENESIS|PROTEOLYSIS PLASMA MEMBRANE Putative GPI-anchored aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance fungal-type cell wall organization aspartic-type endopeptidase activity fungal-type cell wall
YGR032W YGR032W GSC2 hom Verified 1.32629220056356 0.0923714646433053 no 516 0.0720416112956237 256 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM PLASMA MEMBRANE|CYTOSKELETON Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p) ascospore wall assembly|(1->3)-beta-D-glucan biosynthetic process 1,3-beta-D-glucan synthase activity 1,3-beta-D-glucan synthase complex|integral to membrane|actin cap|prospore membrane
YOR020W-A_p YOR020W-A YOR020W-A hom Uncharacterized 1.32099699704082 0.0932511827540891 no 517 0.0770508022914374 291 NA FT MITOCHONDRION Putative protein of unknown function, conserved in A. gossypii; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YDR058C YDR058C TGL2 hom Verified 1.31958528803236 0.0934867587331497 no 518 0.0970662871056603 398 NA FT PROTEIN LOCALIZATION|LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION Triacylglycerol lipase that is localized to the mitochondria; has lipolytic activity towards triacylglycerols and diacylglycerols when expressed in E. coli triglyceride catabolic process triglyceride lipase activity mitochondrion
YLR377C YLR377C FBP1 hom Verified 1.31910248863559 0.0935674256521774 no 519 0.0977739247642185 383 NA FT CARBOHYDRATE METABOLISM Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism; undergoes either proteasome-mediated or autophagy-mediated degradation depending on growth conditions; interacts with Vid30p gluconeogenesis|reactive oxygen species metabolic process fructose 1,6-bisphosphate 1-phosphatase activity cytosol
YJR090C YJR090C GRR1 hom Verified 1.31858450013782 0.0936540291695158 no 520 0.122375288512238 486 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CARBOHYDRATE METABOLISM|PROTEOLYSIS NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON UBIQUITIN LIGASE COMPLEX F-box protein component of the SCF ubiquitin-ligase complex; involved in carbon catabolite repression, glucose-dependent divalent cation transport, high-affinity glucose transport, morphogenesis, and sulfite detoxification SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular response to methylmercury|cell cycle arrest in response to pheromone|G1/S transition of mitotic cell cycle|response to DNA damage stimulus|protein ubiquitination ubiquitin-protein ligase activity|protein binding, bridging cellular bud neck contractile ring|SCF ubiquitin ligase complex|nucleus|cytoplasm
YNL328C YNL328C MDJ2 hom Verified 1.31696425128023 0.0939253038603817 no 521 0.112646168898304 403 NA FT PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Constituent of the mitochondrial import motor associated with the presequence translocase; function overlaps with that of Pam18p; stimulates the ATPase activity of Ssc1p to drive mitochondrial import; contains a J domain protein import into mitochondrial matrix protein transporter activity|ATPase activator activity mitochondrial inner membrane|presequence translocase-associated import motor
YER010C YER010C YER010C hom Verified 1.31435233839294 0.0943638308847652 no 522 0.098986355697995 413 NA Protein of unknown function, forms a ring-shaped homotrimer; has similarity to members of the prokaryotic rraA family; possibly involved in a phosphotransfer reaction biological_process molecular_function cellular_component
YBL102W YBL102W SFT2 hom Verified 1.31326904484509 0.0945461527283159 no 523 0.110125790888449 417 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Non-essential tetra-spanning membrane protein found mostly in the late Golgi, can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to mammalian syntaxin 5 Golgi to endosome transport molecular_function integral to membrane|Golgi membrane
YOR082C_d YOR082C YOR082C hom Dubious 1.31269519835913 0.0946428381241348 no 524 0.08334552186696 310 NA Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene YOR083W Unknown Unknown Unknown
YOL154W YOL154W ZPS1 hom Verified 1.31227266160678 0.0947140764436993 no 525 0.0696922319043446 272 NA Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH biological_process molecular_function fungal-type cell wall|fungal-type vacuole
YNL273W YNL273W TOF1 hom Verified 1.3081092936479 0.0954181208396647 no 526 0.0853993618740786 315 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Subunit of a replication-pausing checkpoint complex (Tof1p-Mrc1p-Csm3p) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase DNA repair|DNA replication checkpoint|maintenance of DNA repeat elements|replication fork arrest|replication fork protection|DNA replication|mitotic sister chromatid cohesion molecular_function nuclear chromosome|replication fork protection complex|nuclear replication fork
YGL180W YGL180W ATG1 hom Verified 1.30496061476991 0.0959531296451498 no 527 0.0870258676098398 336 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Protein ser/thr kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for phagophore assembly site formation; during autophagy forms a complex with Atg13p and Atg17p piecemeal microautophagy of nucleus|mitochondrion degradation|protein phosphorylation|CVT pathway|autophagic vacuole assembly protein serine/threonine kinase activity|protein kinase activity cytosol|pre-autophagosomal structure|Atg1p signaling complex
YGL038C YGL038C OCH1 hom Verified 1.304549854521 0.0960230864563562 no 528 0.120601964495181 432 NA FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Mannosyltransferase of the cis-Golgi apparatus, initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins protein N-linked glycosylation alpha-1,6-mannosyltransferase activity|transferase activity, transferring glycosyl groups Golgi cis cisterna
YHR192W YHR192W LNP1 hom Verified 1.30443286563283 0.0960430177605409 no 529 0.13546941496938 499 NA Lunapark family member involved in ER network formation; localizes to ER junctions and this localization is regulated by the yeast atlastin ortholog Sey1p; interacts with the reticulon protein Rtn1p; induced in response to the DNA-damaging agent MMS endoplasmic reticulum tubular network organization molecular_function endoplasmic reticulum tubular network|cytoplasm
YGR106C YGR106C VOA1 hom Verified 1.30440362209833 0.0960480004335493 no 530 0.158536823712151 586 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Endoplasmic reticulum protein that functions, together with other assembly factors, in assembly of the V0 sector of the vacuolar ATPase (V-ATPase); null mutation enhances the V-ATPase deficiency of a vma21 mutant impaired in ER retrieval protein complex assembly molecular_function fungal-type vacuole membrane|endoplasmic reticulum membrane
YGL129C YGL129C RSM23 hom Verified 1.2979187598821 0.09715762644248 no 531 0.110745612078314 448 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit, has similarity to mammalian apoptosis mediator proteins; null mutation prevents induction of apoptosis by overproduction of metacaspase Mca1p mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YJL178C YJL178C ATG27 hom Verified 1.29599898780179 0.0974879168073493 no 532 0.0996231578973618 377 NA FT PROTEIN LOCALIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION ENDOMEMBRANE SYSTEM|MITOCHONDRION|GOLGI APPARATUS Type I membrane protein involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; may be involved in membrane delivery to the phagophore assembly site vesicle organization|peroxisome degradation|protein localization to pre-autophagosomal structure|CVT pathway|autophagic vacuole assembly phosphatidylinositol-3-phosphate binding trans-Golgi network|mitochondrion|pre-autophagosomal structure|membrane
YHR060W YHR060W VMA22 hom Verified 1.29474189103168 0.0977046418389107 no 533 0.0985604011903184 368 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Peripheral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER) vacuolar proton-transporting V-type ATPase complex assembly|vacuolar acidification unfolded protein binding extrinsic to endoplasmic reticulum membrane
YML078W YML078W CPR3 hom Verified 1.29378234815083 0.0978703057792957 no 534 0.105091606087183 430 NA FT MITOCHONDRION Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; involved in protein refolding after import into mitochondria protein folding|apoptotic process peptidyl-prolyl cis-trans isomerase activity mitochondrion
YJR106W YJR106W ECM27 hom Verified 1.29167956176228 0.0982340691316847 no 535 0.0750152259068254 275 NA FT CELL WALL ORG/BIOGENESIS Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants are hypersensitive to Papulacandin B; null mutants have increased plasmid loss; displays a two-hybrid interaction with Pdr5p fungal-type cell wall organization molecular_function integral to membrane
YIL011W YIL011W TIR3 hom Verified 1.2908986978708 0.0983694035022717 no 536 0.0803901704750526 334 NA Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth biological_process molecular_function fungal-type cell wall
YPR007C YPR007C REC8 hom Verified 1.29052021121381 0.0984350495136235 no 537 0.100807401522129 366 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p synaptonemal complex assembly|protein localization to chromosome, centromeric region|reciprocal meiotic recombination|meiotic sister chromatid cohesion molecular_function condensed nuclear chromosome|condensed nuclear chromosome, centromeric region
YDL131W YDL131W LYS21 hom Verified 1.28347387164599 0.0996630539029471 no 538 0.0717682378396543 281 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS|MITOCHONDRION Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS21 has a paralog, LYS20, that arose from the whole genome duplication lysine biosynthetic process via aminoadipic acid homocitrate synthase activity nucleus
YPL107W_p YPL107W YPL107W hom Uncharacterized 1.28241872516386 0.0998478994834175 no 539 0.0964863922304306 371 NA FT MITOCHONDRION Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YPL107W is not an essential gene biological_process molecular_function mitochondrion
YML096W_p YML096W YML096W hom Uncharacterized 1.28084987478966 0.100123200933011 no 540 0.117249646459039 438 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Putative protein of unknown function with similarity to asparagine synthetases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YML096W is not an essential gene and partially overlaps the verified gene RAD10 biological_process molecular_function cytoplasm
YBR224W_d YBR224W YBR224W hom Dubious 1.27962586831772 0.100338373803405 no 541 0.0854899299297669 349 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TDP1 Unknown Unknown Unknown
YDR036C YDR036C EHD3 hom Verified 1.27928615492943 0.100398153131282 no 542 0.0793895203861224 312 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION 3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis fatty acid beta-oxidation|biological_process 3-hydroxyisobutyryl-CoA hydrolase activity mitochondrion
YML067C YML067C ERV41 hom Verified 1.27897560004964 0.100452824174824 no 543 0.101271582500477 389 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Protein localized to COPII-coated vesicles, forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 (PTX1) protein ER to Golgi vesicle-mediated transport molecular_function integral to endoplasmic reticulum membrane|integral to Golgi membrane|ER to Golgi transport vesicle
YOR356W YOR356W CIR2 hom Verified 1.27878644588226 0.100486134103643 no 544 0.0965011475705925 373 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Putative ortholog of human electron transfer flavoprotein dehydrogenase (ETF-dH); found in a large supramolecular complex with other mitochondrial dehydrogenases; may have a role in oxidative stress response biological_process molecular_function mitochondrion
YOR239W YOR239W ABP140 hom Verified 1.27692474572075 0.100814408394281 no 545 0.0931153371688767 326 NA FT RNA PROCESSING|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON AdoMet-dependent tRNA methyltransferase and actin binding protein; C-terminal domain is responsible for 3-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA-Thr and tRNA-Ser and contains an S-adenosylmethionine (AdoMet) binding motif; N-terminal actin binding sequence interacts with actin filaments and localizes to actin patches and cables; N- and C-terminal domains are encoded in separate ORFs that are translated into one protein via a +1 frameshift actin filament bundle assembly|tRNA methylation tRNA (cytosine-3-)-methyltransferase activity|actin filament binding|protein binding, bridging actin filament|actin filament bundle|mating projection tip|actin cortical patch
YOR093C_p YOR093C YOR093C hom Uncharacterized 1.27546333941677 0.101072646068458 no 546 0.0642632601567625 237 NA FT NUCLEUS Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents biological_process molecular_function integral to membrane
YKL015W YKL015W PUT3 hom Verified 1.27059407545191 0.101936547866776 no 547 0.080910199351888 311 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Transcriptional activator of proline utilization genes, constitutively binds PUT1 and PUT2 promoter sequences as a dimer and undergoes a conformational change to form the active state; differentially phosphorylated in the presence of different nitrogen sources; has a Zn(2)-Cys(6) binuclear cluster domain Unknown|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YHR157W YHR157W REC104 hom Verified 1.27027265335697 0.101993762872373 no 548 0.0900707832808438 395 NA FT CELL CYCLE NUCLEUS|CHROMOSOME Protein involved in early stages of meiotic recombination; required for meiotic crossing over; forms a complex with Rec102p and Spo11p necessary during the initiation of recombination meiotic DNA double-strand break formation|reciprocal meiotic recombination molecular_function condensed nuclear chromosome
YOR091W YOR091W TMA46 hom Verified 1.26530040278227 0.102881831124485 no 549 0.112049685587314 421 NA FT TRANSLATION Protein of unknown function that associates with translating ribosomes; interacts with GTPase Rbg1p cytoplasmic translation molecular_function polysomal ribosome|ribosome|cytoplasm
YKL011C YKL011C CCE1 hom Verified 1.26360514203246 0.103185893533869 no 550 0.112541245063131 457 NA FT MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial cruciform cutting endonuclease, cleaves Holliday junctions formed during recombination of mitochondrial DNA mitochondrial genome maintenance endodeoxyribonuclease activity mitochondrial inner membrane
YHR185C YHR185C PFS1 hom Verified 1.25988419600569 0.103855570346381 no 551 0.112754053518405 398 NA FT CELL WALL ORG/BIOGENESIS NUCLEUS|CYTOSKELETON Sporulation protein required for prospore membrane formation at selected spindle poles, ensures functionality of all four spindle pole bodies during meiosis II; not required for meiotic recombination or meiotic chromosome segregation ascospore wall assembly molecular_function cellular_component
YBR072W YBR072W HSP26 hom Verified 1.2597668954921 0.103876732627369 no 552 0.094409133140629 385 NA FT NUCLEUS Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires heat-induced conformational change; also has mRNA binding activity protein folding|response to stress unfolded protein binding|mRNA binding nucleus|cytoplasm
YOL085C_d YOL085C YOL085C hom Dubious 1.25862838259532 0.104082295176849 no 553 0.102427922637508 359 NA Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A Unknown Unknown Unknown
YNR063W_p YNR063W YNR063W hom Uncharacterized 1.25823718418604 0.104152995476216 no 554 0.088831104001153 353 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Putative zinc-cluster protein of unknown function biological_process sequence-specific DNA binding cellular_component
YHR130C_d YHR130C YHR130C hom Dubious 1.25803963427747 0.104188711398561 no 555 0.109924132699792 386 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOR354C YOR354C MSC6 hom Verified 1.25795441821194 0.104204120728815 no 556 0.11440280216009 415 NA FT CELL CYCLE MITOCHONDRION Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies reciprocal meiotic recombination molecular_function mitochondrion
YGL227W YGL227W VID30 hom Verified 1.2569799716631 0.104380444036303 no 557 0.10483901166855 371 NA FT KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS NUCLEUS Central component of GID Complex, involved in FBPase degradation; interacts strongly with Gid8p to serve as a scaffold for other GID Complex subunits; contains SPRY domain and 3 domains that are also found in Gid8p - LisH, CTLH, and CRA; required for association of Vid vesicles and actin patches in vacuole import and degradation pathway; shifts the balance of nitrogen metabolism toward glutamate production; localizes to the nucleus and the cytoplasm regulation of nitrogen utilization|negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|vacuolar protein catabolic process molecular_function nucleus|GID complex|cytoplasm
YKR043C YKR043C SHB17 hom Verified 1.25575001235144 0.104603310187978 no 558 0.142159071244218 482 NA FT CARBOHYDRATE METABOLISM NUCLEUS Sedoheptulose bisphosphatase involved in riboneogenesis; dephosphorylates sedoheptulose 1,7-bisphosphate, which is converted via the nonoxidative pentose phosphate pathway to ribose-5-phosphate; facilitates the conversion of glycolytic intermediates to pentose phosphate units; also has fructose 1,6-bisphosphatase activity but this is probably not biologically relevant, since deletion does not affect FBP levels; GFP-fusion protein localizes to the cytoplasm and nucleus ribose phosphate biosynthetic process sedoheptulose-bisphosphatase activity nucleus|cytoplasm
YDR093W YDR093W DNF2 hom Verified 1.25524303391244 0.104695273911453 no 559 0.0918448663753683 356 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase intracellular protein transport|phospholipid translocation|endocytosis|establishment or maintenance of cell polarity phospholipid-translocating ATPase activity integral to membrane|plasma membrane
YJR095W YJR095W SFC1 hom Verified 1.25276365244348 0.105145866608849 no 560 0.0965412206532022 352 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization succinate transport|fumarate transport succinate:fumarate antiporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YBR120C YBR120C CBP6 hom Verified 1.25182732962532 0.10531639465851 no 561 0.0987404714649512 367 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex positive regulation of mitochondrial translation|mitochondrial respiratory chain complex III assembly ribosome binding mitochondrion|mitochondrial ribosome
YLR412W YLR412W BER1 hom Verified 1.24410216840834 0.106730981547936 no 562 0.0996586554737572 396 NA FT CYTOSKELETON Protein involved in microtubule-related processes, N-acetylation; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene; similar to Arabidopsis SRR1 gene biological_process molecular_function cytoplasm
YJL119C_d YJL119C YJL119C hom Dubious 1.24282701532169 0.106965792545893 no 563 0.0836151201879537 296 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGL015C_p YGL015C YGL015C hom Uncharacterized 1.24230364984905 0.107062274616147 no 564 0.0896730408709055 323 NA Putative protein of unknown function; null mutants accumulate cargo in the Golgi biological_process molecular_function cellular_component
YER188W_d YER188W YER188W hom Dubious 1.24225905646291 0.107070498277599 no 565 0.135881220945105 462 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; large-scale analyses show mRNA expression increases under anaerobic conditions and two-hybrid interactions with Sst2p Unknown Unknown Unknown
YLR236C_d YLR236C YLR236C hom Dubious 1.23905903573939 0.107661817982749 no 566 0.0915927427056847 357 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YKL023W_p YKL023W YKL023W hom Uncharacterized 1.2385995376236 0.107746919708286 no 567 0.0987138021009433 445 NA Putative protein of unknown function, predicted by computational methods to be involved in mRNA degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm biological_process molecular_function cytoplasm
YKL018C-A_p YKL018C-A YKL018C-A hom Uncharacterized 1.23825383844055 0.107810977144541 no 568 0.081265885618798 348 NA Putative protein of unknown function; identified by homology; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm biological_process molecular_function cytoplasm
YIL099W YIL099W SGA1 hom Verified 1.23794342391631 0.10786851976726 no 569 0.100423785850558 376 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation ascospore formation|glycogen catabolic process glucan 1,4-alpha-glucosidase activity fungal-type vacuole
YJL065C YJL065C DLS1 hom Verified 1.23772475017297 0.107909069359181 no 570 0.136655306181337 466 NA FT GENE SILENCING NUCLEUS Subunit of ISW2/yCHRAC chromatin accessibility complex; ISW2/yCHRAC also includes Itc1p, Isw2p, and Dpb4p; involved in inheritance of telomeric silencing; DLS1 has a paralog, DPB3, that arose from the whole genome duplication chromatin silencing at telomere molecular_function chromatin accessibility complex|nucleus
YMR031C YMR031C EIS1 hom Verified 1.23586246913856 0.108254844853744 no 571 0.117649235530938 396 NA FT PROTEIN COMPLEX ORG/BIOGENESIS MITOCHONDRION|PLASMA MEMBRANE Component of the eisosome required for proper eisosome assembly; similarity to Ykl050cp and Uso1p; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress eisosome assembly molecular_function eisosome|mitochondrion|membrane raft|cytoplasm
YKR020W YKR020W VPS51 hom Verified 1.234292230415 0.108547015030852 no 572 0.149766649133376 547 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL DIVISION|VACUOLAR TRANSPORT GOLGI APPARATUS Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; links the (VFT/GARP) complex to the SNARE Tlg1p vesicle organization|retrograde transport, endosome to Golgi|budding cell apical bud growth|regulation of cell size|protein targeting to vacuole protein binding Golgi apparatus|GARP complex
YML058W YML058W SML1 hom Verified 1.23369398957586 0.108658477216446 no 573 0.0681153876859317 264 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION NUCLEUS Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase mitochondrion organization|response to DNA damage stimulus enzyme inhibitor activity nucleus|cytoplasm
YFR020W_p YFR020W YFR020W hom Uncharacterized 1.23334932433661 0.108722731426981 no 574 0.113888870065837 401 NA Protein of unknown function; mRNA identified as translated by ribosome profiling data biological_process molecular_function cellular_component
YFR055W_p YFR055W IRC7 hom Uncharacterized 1.22804851921743 0.109714377387106 no 575 0.115892095764576 431 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Beta-lyase involved in the production of thiols; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner and by copper levels in a Mac1-dependent manner sulfur compound metabolic process|L-cysteine catabolic process to pyruvate cysteine-S-conjugate beta-lyase activity cellular_component
YOR002W YOR002W ALG6 hom Verified 1.22761618142012 0.109795542259811 no 576 0.158030892212683 608 NA FT LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Alpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease oligosaccharide-lipid intermediate biosynthetic process|protein glycosylation|aerobic respiration transferase activity, transferring hexosyl groups|dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity integral to membrane|endoplasmic reticulum
YOR179C YOR179C SYC1 hom Verified 1.22533973571351 0.110223621401612 no 577 0.106842151268802 418 NA FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS Subunit of the APT subcomplex of cleavage and polyadenylation factor; may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAs; SYC1 has a paralog, YSH1, that arose from the whole genome duplication termination of RNA polymerase II transcription, exosome-dependent|termination of RNA polymerase II transcription, poly(A)-coupled RNA binding mRNA cleavage and polyadenylation specificity factor complex|nucleus
YOR214C_p YOR214C YOR214C hom Uncharacterized 1.22400819180998 0.110474568642822 no 578 0.102246307546242 344 NA Putative protein of unknown function; YOR214C is not an essential gene biological_process molecular_function fungal-type cell wall
YKL159C YKL159C RCN1 hom Verified 1.22056217259969 0.11112591801589 no 579 0.102106953906955 390 NA FT SIGNALING Protein involved in calcineurin regulation during calcium signaling; has similarity to H. sapiens DSCR1 which is found in the Down Syndrome candidate region calcium-mediated signaling protein phosphatase 2B binding|calcium-dependent protein serine/threonine phosphatase regulator activity cytoplasm
YLR126C YLR126C YLR126C hom Verified 1.22055477175392 0.111127319839912 no 580 0.0998394866087239 380 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS Putative glutamine amidotransferase; has Aft1p-binding motif in the promoter; may be involved in copper and iron homeostasis; YLR126C is not an essential protein; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress cellular copper ion homeostasis|cellular iron ion homeostasis molecular_function cytoplasm
YKL137W YKL137W CMC1 hom Verified 1.22002400568935 0.111227887400293 no 581 0.108373141342113 442 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Evolutionarily conserved copper-binding protein of the mitochondrial intermembrane space, may be involved in delivering copper from the matrix to the cytochrome c oxidase complex; contains a twin CX9C motif mitochondrial respiratory chain complex IV assembly copper ion binding extrinsic to mitochondrial inner membrane|mitochondrial intermembrane space
YPL145C YPL145C KES1 hom Verified 1.219287975935 0.111367455360817 no 582 0.127591949969885 473 NA FT VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|GOLGI APPARATUS One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication post-Golgi vesicle-mediated transport|positive regulation of phosphatase activity|maintenance of cell polarity|endocytosis|exocytosis|sterol transport phosphatidic acid binding|lipid binding|phosphatidylinositol-4,5-bisphosphate binding|oxysterol binding|sterol transporter activity|phosphatidylinositol-4-phosphate binding Golgi membrane|extrinsic to membrane|cytoplasm
YJL135W_d YJL135W YJL135W hom Dubious 1.2192179305731 0.111380744082003 no 583 0.0892681901089051 323 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3 Unknown Unknown Unknown
YOL136C YOL136C PFK27 hom Verified 1.21783416102732 0.111643499926342 no 584 0.100910845742233 396 NA FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY 6-phosphofructo-2-kinase, catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A regulation of glycolysis|fructose 2,6-bisphosphate metabolic process 6-phosphofructo-2-kinase activity cytoplasm
YNL183C YNL183C NPR1 hom Verified 1.21709117741326 0.111784763546761 no 585 0.101276255401528 401 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION GOLGI APPARATUS|PLASMA MEMBRANE Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex regulation of transmembrane transporter activity|regulation of nitrogen utilization|protein phosphorylation|negative regulation of endocytosis protein serine/threonine kinase activity Golgi apparatus|plasma membrane|cytoplasm
YDR203W_d YDR203W YDR203W hom Dubious 1.21606660158104 0.111979775991229 no 586 0.152877347498581 588 NA FF Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR264C YDR264C AKR1 hom Verified 1.21412875700971 0.112349280131325 no 587 0.214333289544523 742 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats; AKR1 has a paralog, AKR2, that arose from the whole genome duplication protein targeting to membrane|regulation of endocytosis|regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion|protein palmitoylation palmitoyltransferase activity integral to membrane|Golgi apparatus|membrane
YFR001W YFR001W LOC1 hom Verified 1.21398520053767 0.112376687798127 no 588 0.122786776961025 450 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|RNA LOCALIZATION NUCLEUS Nuclear protein involved in asymmetric localization of ASH1 mRNA; binds double-stranded RNA in vitro; constituent of 66S pre-ribosomal particles; relocalizes from nucleus to cytoplasm upon DNA replication stress endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal large subunit biogenesis|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|intracellular mRNA localization mRNA binding nucleolus|preribosome, large subunit precursor
YGL136C YGL136C MRM2 hom Verified 1.21315744144189 0.112534815978079 no 589 0.0827671009206215 306 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS MITOCHONDRION Mitochondrial 2' O-ribose methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ rRNA methylation rRNA (uridine-2'-O-)-methyltransferase activity mitochondrion
YLR065C YLR065C ENV10 hom Verified 1.2115333355386 0.112845533303663 no 590 0.151622176943837 598 NA FF|FT VACUOLAR PROTEIN PROCESSING Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing; YLR065C is not an essential gene vacuolar protein processing molecular_function integral to membrane
YER079W_p YER079W YER079W hom Uncharacterized 1.20989791659743 0.113159033391028 no 591 0.104633435030126 378 NA FT NUCLEUS Putative protein of unknown function biological_process molecular_function nucleus|cytoplasm
YOR011W YOR011W AUS1 hom Verified 1.20881877440225 0.113366238553634 no 592 0.126760446845626 462 NA FT NUCLEOTIDE METABOLISM MITOCHONDRION|PLASMA MEMBRANE Plasma membrane sterol transporter of the ATP-binding cassette family; required, along with Pdr11p, for uptake of exogenous sterols and their incorporation into the plasma membrane; activity is stimulated by phosphatidylserine; sterol uptake is required for anaerobic growth because sterol biosynthesis requires oxygen sterol import sterol-transporting ATPase activity mitochondrion|integral to membrane|plasma membrane
YGL042C_d YGL042C YGL042C hom Dubious 1.20857476635043 0.113413127818287 no 593 0.113555368996342 408 NA Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene DST1 Unknown Unknown Unknown
YEL001C YEL001C IRC22 hom Verified 1.20545473800803 0.114013900548915 no 594 0.0838450009973234 311 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci biological_process molecular_function endoplasmic reticulum
YNR006W YNR006W VPS27 hom Verified 1.20281066923143 0.114524797560427 no 595 0.159381562834555 582 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p) protein retention in Golgi apparatus|late endosome to vacuole transport|protein targeting to vacuole ubiquitin binding|phosphatidylinositol-3-phosphate binding endosome|ESCRT-0 complex
YFL014W YFL014W HSP12 hom Verified 1.20245013189869 0.114594588000496 no 596 0.0745880620161861 248 NA FT MEMBRANE ORGANIZATION|RESPONSE TO OXIDATIVE STRESS NUCLEUS|PLASMA MEMBRANE Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension cellular response to oxidative stress|cell adhesion|plasma membrane organization|cellular response to osmotic stress|cellular response to heat lipid binding cytosol|endosome|nucleus|plasma membrane|cytoplasm
YBR159W YBR159W IFA38 hom Verified 1.2002695829011 0.11501732944885 no 597 0.115394443325992 460 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Microsomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides fatty acid elongation ketoreductase activity integral to membrane|endoplasmic reticulum
YFL023W YFL023W BUD27 hom Verified 1.19847403347519 0.115366262997656 no 598 0.118161189545177 520 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION RIBOSOME Unconventional prefoldin protein involved in translation initiation; mutants have inappropriate expression of nutrient sensitive genes due to translational derepression of Gcn4p transcription factor; diploid mutants show random budding; ortholog of human URI/RMP formation of translation preinitiation complex molecular_function cytosolic ribosome|cytoplasm
YOR313C YOR313C SPS4 hom Verified 1.19521399064718 0.116001716852344 no 599 0.114392141638999 446 NA FT CELL CYCLE Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage ascospore formation molecular_function cellular_component
YGR289C YGR289C MAL11 hom Verified 1.1949825242238 0.116046929025533 no 600 0.134430346078328 535 NA FT CARBOHYDRATE METABOLISM PLASMA MEMBRANE Inducible high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL1 complex locus; broad substrate specificity that includes maltotriose; required for isomaltose utilization trehalose transport|maltose transport|disaccharide catabolic process trehalose transmembrane transporter activity|alpha-glucoside:hydrogen symporter activity|maltose:hydrogen symporter activity integral to membrane|plasma membrane
YML119W_p YML119W YML119W hom Uncharacterized 1.19462191269747 0.116117391942647 no 601 0.111356781008841 337 NA Putative protein of unknown function; YML119W is not an essential gene; potential Cdc28p substrate biological_process molecular_function cellular_component
YDR432W YDR432W NPL3 hom Verified 1.19426445112881 0.116187269327961 no 602 0.144915744236647 557 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION NUCLEUS RNA-binding protein; promotes elongation, regulates termination, and carries poly(A) mRNA from nucleus to cytoplasm; has a role in repressing translation initiation by binding eIF4G; required for pre-mRNA splicing; dissociation from mRNAs promoted by Mtr10p; phosphorylated by Sky1p in the cytoplasm; protein abundance increases in response to DNA replication stress translational termination|mRNA export from nucleus|negative regulation of translation|mRNA splicing, via spliceosome|Unknown|positive regulation of transcription elongation from RNA polymerase II promoter mRNA binding|RNA polymerase II core binding|eukaryotic initiation factor 4G binding|poly(A) RNA binding nucleus|cytoplasm
YLR394W YLR394W CST9 hom Verified 1.19310056020588 0.116414996077591 no 603 0.111825223150886 378 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME SUMO E3 ligase; required for synaptonemal complex formation; localizes to synapsis initiation sites on meiotic chromosomes; potential Cdc28p substrate synaptonemal complex assembly|protein sumoylation|synapsis|reciprocal meiotic recombination SUMO ligase activity condensed nuclear chromosome|nuclear chromosome
YER145C YER145C FTR1 hom Verified 1.19196384853499 0.116637710388756 no 604 0.126175637562373 517 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE High affinity iron permease; involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron; protein abundance increases in response to DNA replication stress iron assimilation by reduction and transport|high-affinity iron ion transport|transmembrane transport iron ion transmembrane transporter activity high affinity iron permease complex|integral to membrane|plasma membrane
YFL020C YFL020C PAU5 hom Verified 1.18862854530802 0.117292934950105 no 605 0.0972015280552936 386 NA Member of the seripauperin multigene family encoded mainly in subtelomeric regions; induced during alcoholic fermentation; induced by low temperature and also by anaerobic conditions; negatively regulated by oxygen and repressed by heme biological_process molecular_function integral to membrane|cytoplasm
YER047C YER047C SAP1 hom Verified 1.18798705048538 0.117419255771941 no 606 0.131128464495341 495 NA Putative ATPase of the AAA family, interacts with the Sin1p transcriptional repressor in the two-hybrid system biological_process ATPase activity cytoplasm
YJR038C_d YJR038C YJR038C hom Dubious 1.18714847748342 0.117584529742049 no 607 0.107348826371276 387 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOL116W YOL116W MSN1 hom Verified 1.18706538446602 0.117600915469951 no 608 0.120516351799702 437 NA FT TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM NUCLEUS Transcriptional activator; involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress; localizes to the nucleus; relative distribution to the nucleus increases upon DNA replication stress positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription from RNA polymerase II promoter in response to methylglyoxal|positive regulation of transcription from RNA polymerase II promoter in response to increased salt|Unknown|positive regulation of starch catabolic process by positive regulation of transcription from RNA polymerase II promoter|positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding nucleus
YDR262W_p YDR262W YDR262W hom Uncharacterized 1.18623552939511 0.117764649426954 no 609 0.0882851138094953 333 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole and is induced in response to the DNA-damaging agent MMS; gene expression increases in response to Zymoliase treatment biological_process molecular_function fungal-type vacuole
YHL008C_p YHL008C YHL008C hom Uncharacterized 1.18587594061505 0.117835647906834 no 610 0.118974977200619 436 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Putative protein of unknown function, may be involved in the uptake of chloride ions; does not appear to be involved in monocarboxylic acid transport; green fluorescent protein (GFP)-fusion protein localizes to the vacuole chloride transport|monocarboxylic acid transport monocarboxylic acid transmembrane transporter activity|transporter activity integral to membrane|fungal-type vacuole
YPR060C YPR060C ARO7 hom Verified 1.18432516925845 0.118142184635348 no 611 0.169419361128361 655 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Chorismate mutase, catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis aromatic amino acid family biosynthetic process chorismate mutase activity nucleus|cytoplasm
YPR151C YPR151C SUE1 hom Verified 1.18293815130484 0.118416830062455 no 612 0.0856329248046426 294 NA FT PROTEOLYSIS MITOCHONDRION Mitochondrial protein required for degradation of unstable forms of cytochrome c protein catabolic process molecular_function mitochondrial envelope
YOR045W YOR045W TOM6 hom Verified 1.18281659592506 0.118440920909703 no 613 0.113919596983208 448 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex mitochondrial outer membrane translocase complex assembly|protein import into mitochondrial matrix protein channel activity mitochondrion|integral to membrane|mitochondrial outer membrane translocase complex
YOR357C YOR357C SNX3 hom Verified 1.18271833180621 0.118460398234809 no 614 0.12059410635345 439 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p protein localization|late endosome to Golgi transport phosphatidylinositol-3-phosphate binding cytosol|endosome
YPL102C_d YPL102C YPL102C hom Dubious 1.18247905752622 0.118507835217043 no 615 0.118262802092745 434 NA Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation enhances replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene ELP4 Unknown Unknown Unknown
YOL125W YOL125W TRM13 hom Verified 1.18238864641661 0.118525763037353 no 616 0.0794726885680851 314 NA FT RNA PROCESSING NUCLEUS 2'-O-methyltransferase responsible for modification of tRNA at position 4; C-terminal domain has similarity to Rossmann-fold (RFM) superfamily of RNA methyltransferases tRNA methylation tRNA methyltransferase activity nucleus|cytoplasm
YER178W YER178W PDA1 hom Verified 1.18072581762394 0.11885583090378 no 617 0.137707072704739 493 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose acetyl-CoA biosynthetic process from pyruvate pyruvate dehydrogenase (acetyl-transferring) activity mitochondrial nucleoid|mitochondrion|mitochondrial pyruvate dehydrogenase complex
YLR211C_p YLR211C YLR211C hom Uncharacterized 1.17940605567267 0.11911826246982 no 618 0.103262958537977 376 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR211C is not an essential gene; ORF contains an intron biological_process molecular_function cytoplasm
YBR197C YBR197C YBR197C hom Verified 1.17899702012675 0.119199681204119 no 619 0.118845774813981 422 NA FT NUCLEUS Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR197C is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress; YBR197C has a paralog, YPL077C, that arose from the whole genome duplication biological_process molecular_function nucleus|cytoplasm
YOR008C-A_p YOR008C-A YOR008C-A hom Uncharacterized 1.17642766126435 0.119712011779337 no 620 0.103203069547076 350 NA Putative protein of unknown function, includes a potential transmembrane domain; deletion results in slightly lengthened telomeres biological_process molecular_function cellular_component
YJL160C_p YJL160C YJL160C hom Uncharacterized 1.17566471913451 0.119864441148876 no 621 0.151879545947713 519 NA Putative protein of unknown function; member of the PIR (proteins with internal repeats) family of cell wall proteins; non-essential gene that is required for sporulation; mRNA is weakly cell cycle regulated, peaking in mitosis; YJL160C has a paralog, PIR1, that arose from the whole genome duplication biological_process molecular_function cellular_component
YBR003W YBR003W COQ1 hom Verified 1.17528834868133 0.119939687155519 no 622 0.136788813250839 507 NA FT KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM MITOCHONDRION Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis ubiquinone biosynthetic process trans-hexaprenyltranstransferase activity mitochondrion
YOR043W YOR043W WHI2 hom Verified 1.17489238850719 0.120018885580968 no 623 0.0987212034699586 380 NA FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression response to salt stress|mitochondrion degradation|actin filament organization|endocytosis|response to heat|regulation of growth|response to stress phosphatase activator activity cellular_component
YLR128W YLR128W DCN1 hom Verified 1.17457562003587 0.120082270921361 no 624 0.137842600924515 463 NA Scaffold-type E3 ligase required for cullin neddylation and ubiquitin ligase activation; contains a ubiquitin-binding domain (UBA) for ubiquitin and Nedd8 (Rub1p) interaction and a PONY domain involved in cullin binding and neddylation protein neddylation|positive regulation of ubiquitin-protein ligase activity ubiquitin binding|NEDD8 ligase activity|small conjugating protein binding cellular_component
YFL004W YFL004W VTC2 hom Verified 1.17281103156474 0.120435796657196 no 625 0.112962096659049 367 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT ENDOPLASMIC RETICULUM Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion polyphosphate metabolic process|vacuolar transport|microautophagy|protein localization|vacuole fusion, non-autophagic molecular_function fungal-type vacuole membrane|integral to membrane|endoplasmic reticulum|vacuolar transporter chaperone complex
YHR035W_p YHR035W YHR035W hom Uncharacterized 1.17105283120718 0.120788770985443 no 626 0.0820162637196361 319 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM Putative protein of unknown function; not an essential gene biological_process molecular_function cellular_component
YML108W YML108W YML108W hom Verified 1.17087657042795 0.120824197016857 no 627 0.0980081860619436 341 NA FT NUCLEUS Protein of unknown function; structure defines a new subfamily of the split beta-alpha-beta sandwiches; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YML108W is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress biological_process molecular_function nucleus|cytoplasm
YDR095C_d YDR095C YDR095C hom Dubious 1.16987552308758 0.121025532685435 no 628 0.125188710176367 402 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR508C YDR508C GNP1 hom Verified 1.16908810830402 0.121184067270397 no 629 0.0961204033459083 351 NA FT MITOCHONDRION|PLASMA MEMBRANE High-affinity glutamine permease; also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids; GNP1 has a paralog, AGP1, that arose from the whole genome duplication amino acid transport|transmembrane transport amino acid transmembrane transporter activity|L-proline transmembrane transporter activity mitochondrion|integral to membrane|plasma membrane
YPL171C YPL171C OYE3 hom Verified 1.16710965771227 0.121583044087988 no 630 0.124333581532288 473 NA FT OXIDATION-REDUCTION PROCESS Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with different ligand binding and catalytic properties; has potential roles in oxidative stress response and programmed cell death apoptotic process NADPH dehydrogenase activity cellular_component
YIL042C YIL042C PKP1 hom Verified 1.16635019163515 0.121736443916834 no 631 0.0976290953099294 317 NA FT SIGNALING|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION MITOCHONDRION Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p peptidyl-serine phosphorylation|protein phosphorylation|carbon utilization protein kinase activity|pyruvate dehydrogenase (acetyl-transferring) kinase activity mitochondrion
YMR055C YMR055C BUB2 hom Verified 1.16598617662245 0.121810017237011 no 632 0.109215411660224 460 NA FT CELL CYCLE|SIGNALING|CELL DIVISION|NUCLEOTIDE METABOLISM CYTOSKELETON Mitotic exit network regulator, forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anaphase in response to spindle and kinetochore damage regulation of exit from mitosis|mitotic cell cycle spindle orientation checkpoint GTPase activator activity spindle pole body
YER095W YER095W RAD51 hom Verified 1.16505391300061 0.121998585225423 no 633 0.152281154608439 553 NA FF|FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein strand invasion|telomere maintenance via recombination|heteroduplex formation|meiotic joint molecule formation|reciprocal meiotic recombination|double-strand break repair via single-strand annealing recombinase activity|single-stranded DNA binding|DNA-dependent ATPase activity condensed nuclear chromosome|nuclear chromosome
YOR018W YOR018W ROD1 hom Verified 1.16288099528503 0.122438894568462 no 634 0.104365445621028 378 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION PLASMA MEMBRANE Membrane protein, binds the ubiquitin ligase Rsp5p via its 2 PY motifs; overexpression confers resistance to the GST substrate o-dinitrobenzene, zinc, and calcium; proposed to regulate the endocytosis of plasma membrane proteins; protein abundance increases in response to DNA replication stress; ROD1 has a paralog, ROG3, that arose from the whole genome duplication response to drug|ubiquitin-dependent endocytosis ubiquitin protein ligase binding plasma membrane
YIL065C YIL065C FIS1 hom Verified 1.16229155641582 0.122558527609078 no 635 0.116301256860142 460 NA FT MITOCHONDRION ORGANIZATION|PEROXISOME ORGANIZATION MITOCHONDRION Protein involved in mitochondrial membrane fission and peroxisome abundance; required for localization of Dnm1p and Mdv1p during mitochondrial division; mediates ethanol-induced apoptosis and ethanol-induced mitochondrial fragmentation peroxisome fission|mitochondrial fission|chronological cell aging|peroxisome organization molecular_function mitochondrial outer membrane|mitochondrion|peroxisome
YDR439W YDR439W LRS4 hom Verified 1.16213160107846 0.122591006430394 no 636 0.140189731797244 556 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CHROMOSOME SEGREGATION|GENE SILENCING NUCLEUS|CHROMOSOME KINETOCHORE Nucleolar protein that forms a complex with Csm1p, and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation rDNA condensation|chromatin silencing at rDNA|homologous chromosome segregation|protein localization to nucleolar rDNA repeats molecular_function nucleolus|nucleus|monopolin complex
YBR287W_p YBR287W YBR287W hom Uncharacterized 1.16128917931341 0.122762159236291 no 637 0.0972590451017099 323 NA FT ENDOPLASMIC RETICULUM Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene biological_process molecular_function integral to membrane|endoplasmic reticulum
YLR185W YLR185W RPL37A hom Verified 1.1607084465262 0.122880242863925 no 638 0.115908211058672 408 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L37A; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37A has a paralog, RPL37B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YPL192C YPL192C PRM3 hom Verified 1.16027497712688 0.122968434503296 no 639 0.102773986101577 408 NA FT MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON Pheromone-regulated protein required for nuclear envelope fusion during karyogamy; localizes to the outer face of the nuclear membrane; interacts with Kar5p at the spindle pole body karyogamy involved in conjugation with cellular fusion|nuclear membrane fusion involved in karyogamy molecular_function nuclear envelope|spindle pole body|extrinsic to nuclear outer membrane
YMR096W YMR096W SNZ1 hom Verified 1.15952096991127 0.123121946966651 no 640 0.0942415369142546 322 NA FT COFACTOR METABOLISM Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins pyridoxine metabolic process|thiamine biosynthetic process protein binding cellular_component
YJL151C YJL151C SNA3 hom Verified 1.15932334228271 0.123162205266722 no 641 0.112907701079651 406 NA FT VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM Protein involved in efficient MVB sorting of proteins to the vacuole; may function as an RSP5 adapter protein for MVB cargos; integral membrane protein localized to vacuolar intralumenal vesicles cellular protein catabolic process|endosome transport via multivesicular body sorting pathway ubiquitin protein ligase binding fungal-type vacuole lumen|integral to membrane
YMR074C YMR074C YMR074C hom Verified 1.15899984891318 0.123228123315389 no 642 0.101111053671176 382 NA FT NUCLEUS Protein with homology to human PDCD5; PDCD5 is involved in programmed cell death; N-terminal region forms a conserved triple-helix bundle structure; overexpression promotes H2O2-induced apoptosis; YMR074C is not an essential gene; protein abundance increases in response to DNA replication stress apoptotic process molecular_function nucleus|cytoplasm
YBR071W YBR071W YBR071W hom Verified 1.15697696871889 0.123640885069957 no 643 0.110374033850193 383 NA FT SITE OF POLARIZED GROWTH Protein of unknown function found in the cytoplasm and bud neck; mRNA expression may be regulated by the cell cycle and/or cell wall stress; overexpression of YBR071W affects endocytic protein trafficking biological_process molecular_function cellular bud neck|cytoplasm
YPL194W YPL194W DDC1 hom Verified 1.15612207808531 0.123815613269985 no 644 0.110756870935227 400 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME DNA damage checkpoint protein; part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate; forms nuclear foci upon DNA replication stress meiosis|mitotic cell cycle G1/S transition checkpoint|intra-S DNA damage checkpoint|recombinational repair|G2/M transition checkpoint|cell cycle checkpoint molecular_function condensed nuclear chromosome|checkpoint clamp complex
YGL023C YGL023C PIB2 hom Verified 1.15475028464147 0.124096350569328 no 645 0.136112703850195 448 NA FT VESICLE-MEDIATED TRANSPORT MITOCHONDRION Protein of unknown function; contains FYVE domain; similar to Fab1 and Vps27 biological_process molecular_function mitochondrion
YML007W YML007W YAP1 hom Verified 1.15347411999616 0.124357917052647 no 646 0.145668783406189 546 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO OXIDATIVE STRESS NUCLEUS Basic leucine zipper (bZIP) transcription factor; required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; Yap1p is degraded in the nucleus after the oxidative stress has passed; mediates resistance to cadmium; YAP1 has a paralog, CAD1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance|response to heat|response to drug|response to singlet oxygen|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|response to metal ion sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nucleus|cytoplasm
YKL005C YKL005C BYE1 hom Verified 1.1530252810904 0.124450003987279 no 647 0.111908721540423 405 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Negative regulator of transcription elongation, contains a TFIIS-like domain and a PHD finger, multicopy suppressor of temperature-sensitive ess1 mutations, probably binds RNA polymerase II large subunit negative regulation of transcription from RNA polymerase II promoter methylated histone residue binding nucleus
YOL140W YOL140W ARG8 hom Verified 1.15192314753765 0.124676327681461 no 648 0.105142214153141 367 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine arginine biosynthetic process|ornithine biosynthetic process N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity mitochondrion|mitochondrial matrix
YMR307W YMR307W GAS1 hom Verified 1.14923686474616 0.125229161829795 no 649 0.134907507598072 541 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|GENE SILENCING NUCLEUS|MITOCHONDRION|PLASMA MEMBRANE Beta-1,3-glucanosyltransferase, required for cell wall assembly and also has a role in transcriptional silencing; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor; also found at the nuclear periphery fungal-type cell wall organization|chromatin silencing|filamentous growth 1,3-beta-glucanosyltransferase activity mitochondrion|membrane raft|primary cell septum|nuclear periphery|integral to membrane|fungal-type cell wall|plasma membrane|cellular bud scar|ER to Golgi transport vesicle
YDR003W-A_p YDR003W-A YDR003W-A hom Uncharacterized 1.14917795738209 0.125241304051058 no 650 0.143492422334939 478 NA Putative protein of unknown function; identified by expression profiling and mass spectrometry biological_process molecular_function cellular_component
YOR009W YOR009W TIR4 hom Verified 1.14731459875305 0.125625811287138 no 651 0.126474662251539 456 NA FT CELL WALL ORG/BIOGENESIS Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth; transcription is also induced by cold shock biological_process molecular_function fungal-type cell wall
YJL150W_d YJL150W YJL150W hom Dubious 1.14645619726653 0.125803220737766 no 652 0.105161831683171 384 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YKL106C-A_p YKL106C-A YKL106C-A hom Uncharacterized 1.14352392056974 0.126410564457471 no 653 0.0941500073580831 342 NA Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi biological_process molecular_function cellular_component
YPL037C YPL037C EGD1 hom Verified 1.14199504182274 0.126728040316625 no 654 0.140053743732637 489 NA FT PROTEIN LOCALIZATION NUCLEUS Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b 'de novo' cotranslational protein folding unfolded protein binding nascent polypeptide-associated complex
YML021C YML021C UNG1 hom Verified 1.13996177719671 0.127151112843953 no 655 0.125260762202655 512 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION Uracil-DNA glycosylase, required for repair of uracil in DNA formed by spontaneous cytosine deamination, not required for strand-specific mismatch repair, cell-cycle regulated, expressed in late G1, localizes to mitochondria and nucleus DNA repair uracil DNA N-glycosylase activity mitochondrion|nucleus
YFR033C YFR033C QCR6 hom Verified 1.13923450585038 0.127302678538808 no 656 0.126213111766802 481 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Subunit 6 of the ubiquinol cytochrome-c reductase complex; the complex, also known as the cytochrome bc(1) complex or Complex III, is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1; may be loosely associated with the complex since it is easily released into the intermembrane space mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration ubiquinol-cytochrome-c reductase activity mitochondrion|integral to membrane|mitochondrial respiratory chain complex III
YFR013W YFR013W IOC3 hom Verified 1.13804275622374 0.12755131461826 no 657 0.162923417401507 607 NA FT CHROMATIN ORGANIZATION NUCLEUS Subunit of the Isw1a complex; Isw1a has nucleosome-stimulated ATPase activity and represses transcription initiation by specific positioning of a promoter proximal dinucleosome; IOC3 has a paralog, ESC8, that arose from the whole genome duplication chromatin remodeling nucleosome binding|ATPase activity|DNA binding ISW1 complex
YGL138C_p YGL138C YGL138C hom Uncharacterized 1.13742573031439 0.127680178012361 no 658 0.117672085727875 400 NA Putative protein of unknown function; has no significant sequence similarity to any known protein biological_process molecular_function cellular_component
YPR015C_p YPR015C YPR015C hom Uncharacterized 1.13596492081442 0.127985622903804 no 659 0.136967695707113 450 NA Putative protein of unknown function; overexpression causes a cell cycle delay or arrest biological_process sequence-specific DNA binding cellular_component
YGR171C YGR171C MSM1 hom Verified 1.13451790612925 0.128288683518451 no 660 0.137765183044374 487 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION MITOCHONDRION Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p methionyl-tRNA aminoacylation methionine-tRNA ligase activity mitochondrion
YNL270C YNL270C ALP1 hom Verified 1.13386480249325 0.128425631654064 no 661 0.116933124221356 416 NA FT PLASMA MEMBRANE Arginine transporter; expression is normally very low and it is unclear what conditions would induce significant expression; ALP1 has a paralog, CAN1, that arose from the whole genome duplication basic amino acid transport basic amino acid transmembrane transporter activity integral to membrane|plasma membrane
YCR033W YCR033W SNT1 hom Verified 1.13326273304364 0.128551968392169 no 662 0.13252652840883 465 NA FT CELL CYCLE|CHROMATIN ORGANIZATION|SIGNALING NUCLEUS|CHROMOSOME Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein; mutant has increased aneuploidy tolerance negative regulation of meiosis|regulation of transcription, DNA-dependent|histone deacetylation|positive regulation of stress-activated MAPK cascade molecular_function Rpd3L-Expanded complex|Set3 complex
YGL144C YGL144C ROG1 hom Verified 1.12790589440759 0.12967983213295 no 663 0.137993502252306 458 NA FT LIPID METABOLISM Protein with putative serine active lipase domain; ROG1 has a paralog, YDL109C, that arose from the whole genome duplication cellular lipid metabolic process lipase activity cellular_component
YIR023W YIR023W DAL81 hom Verified 1.12676434460581 0.129921064666801 no 664 0.279899628102362 994 NA FF|FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|RESPONSE TO NUTRIENT LEVELS NUCLEUS Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism nitrogen utilization|nitrogen catabolite activation of transcription from RNA polymerase II promoter|gamma-aminobutyric acid catabolic process|urea catabolic process RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor recruiting transcription factor activity nucleus
YPL269W YPL269W KAR9 hom Verified 1.12664810628809 0.129945645587346 no 665 0.172228411893255 622 NA FT NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase nuclear migration along microtubule|establishment of spindle localization molecular_function cell cortex|spindle pole body|mating projection tip
YHR082C YHR082C KSP1 hom Verified 1.12402387538887 0.130501448711565 no 666 0.134557669931254 488 NA FT PROTEIN LOCALIZATION|SIGNALING|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS NUCLEUS Serine/threonine protein kinase; associates with TORC1 and likely involved in TOR signaling cascades; negative regulator of autophagy; nuclear translocation required for haploid filamentous growth; regulates filamentous growth induced nuclear translocation of Bcy1p, Fus3p, and Sks1p; overproduction causes allele-specific suppression of prp20-10; protein abundance increases in response to DNA replication stress TOR signaling cascade|protein phosphorylation|Unknown|cellular protein localization|regulation of filamentous growth|negative regulation of macroautophagy protein serine/threonine kinase activity|protein kinase activity nucleus|cytoplasm
YKR045C_p YKR045C YKR045C hom Uncharacterized 1.12395265542677 0.130516555735581 no 667 0.130955130229414 489 NA Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm biological_process molecular_function cytoplasm
YNL305C YNL305C BXI1 hom Verified 1.12282591596696 0.130755718189387 no 668 0.11658468229071 398 NA FT SIGNALING ENDOPLASMIC RETICULUM|MITOCHONDRION Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p endoplasmic reticulum unfolded protein response|apoptotic process|calcium-mediated signaling molecular_function mitochondrion|integral to membrane|endoplasmic reticulum|fungal-type vacuole
YBR285W_p YBR285W YBR285W hom Uncharacterized 1.12223328786551 0.130881631312702 no 669 0.153114135989677 521 NA Putative protein of unknown function; YBR285W is not an essential gene biological_process molecular_function cellular_component
YBR162W-A YBR162W-A YSY6 hom Verified 1.12140357335865 0.131058057899771 no 670 0.111738341072434 397 NA FT PROTEIN LOCALIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein whose expression suppresses a secretory pathway mutation in E. coli; has similarity to the mammalian RAMP4 protein involved in secretion protein secretion molecular_function endoplasmic reticulum
YPL261C_d YPL261C YPL261C hom Dubious 1.12093656313141 0.131157432988461 no 671 0.126622188611677 514 NA Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YPL260W Unknown Unknown Unknown
YPR030W YPR030W CSR2 hom Verified 1.12040170882793 0.131271308539385 no 672 0.144512441873411 486 NA FT VESICLE-MEDIATED TRANSPORT|TRANSCRIPTION FROM RNA POL II|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS NUCLEUS Nuclear ubiquitin protein ligase binding protein; may regulate utilization of nonfermentable carbon sources and endocytosis of plasma membrane proteins; overproduction suppresses chs5 spa2 lethality at high temp; ubiquitinated by Rsp5p, deubiquitinated by Ubp2p; CSR2 has a paralog, ECM21, that arose from the whole genome duplication fungal-type cell wall organization|regulation of transcription from RNA polymerase II promoter|ubiquitin-dependent endocytosis ubiquitin protein ligase binding nucleus
YBL106C YBL106C SRO77 hom Verified 1.11939227163664 0.13148641327704 no 673 0.18281392882324 664 NA FF|FT VESICLE-MEDIATED TRANSPORT PLASMA MEMBRANE Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lethal giant larvae tumor suppressor; interacts with SNARE protein Sec9p; SRO77 has a paralog, SRO7, that arose from the whole genome duplication exocytosis|Golgi to plasma membrane transport molecular_function plasma membrane
YBR171W YBR171W SEC66 hom Verified 1.11922384768185 0.131522327038226 no 674 0.24172214739191 867 NA FF|FT PROTEIN LOCALIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER posttranslational protein targeting to membrane, translocation|filamentous growth protein transporter activity integral to membrane|Sec62/Sec63 complex|endoplasmic reticulum membrane
YGR235C YGR235C MOS2 hom Verified 1.1189316937115 0.131584640338981 no 675 0.145859403460936 511 NA FT MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial inner membrane protein; non-essential component of the mitochondrial inner membrane organizing system (MINOS, MitOS, or MICOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture cristae formation molecular_function mitochondrion|mitochondrial crista junction|integral to mitochondrial inner membrane
YJR043C YJR043C POL32 hom Verified 1.11697502323118 0.132002502334603 no 676 0.156485889317332 576 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Third subunit of DNA polymerase delta, involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; interacts with Hys2p, PCNA (Pol30p), and Pol1p RNA-dependent DNA replication|lagging strand elongation|postreplication repair|base-excision repair|DNA replication, removal of RNA primer|nucleotide-excision repair|mismatch repair|double-strand break repair via break-induced replication|leading strand elongation DNA-directed DNA polymerase activity|single-stranded DNA specific 3'-5' exodeoxyribonuclease activity delta DNA polymerase complex|nucleus
YHR116W YHR116W COX23 hom Verified 1.11695026791959 0.132007794877169 no 677 0.127240071932021 434 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs mitochondrial respiratory chain complex assembly molecular_function mitochondrion|cytoplasm
YPL260W YPL260W YPL260W hom Verified 1.11686596185903 0.132025820123578 no 678 0.156149775894633 546 NA FT NUCLEUS Putative substrate of cAMP-dependent protein kinase (PKA); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YPL260W is not an essential gene; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus|cytoplasm
YBR063C_p YBR063C YBR063C hom Uncharacterized 1.11685955284593 0.132027190486421 no 679 0.116404758715214 438 NA Putative protein of unknown function; YBR063C is not an essential gene biological_process molecular_function cellular_component
YMR136W YMR136W GAT2 hom Verified 1.11566479731723 0.132282822183325 no 680 0.131287262416824 455 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding RNA polymerase II transcription factor activity nucleus
YNL143C_p YNL143C YNL143C hom Uncharacterized 1.11547001078748 0.132324531327535 no 681 0.151241745201203 461 NA Protein of unknown function; expressed at both mRNA and protein levels biological_process molecular_function cellular_component
YOR222W YOR222W ODC2 hom Verified 1.11353231894056 0.132739937950758 no 682 0.112248214172202 448 NA FT MITOCHONDRION Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism mitochondrial transport dicarboxylic acid transmembrane transporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YMR140W YMR140W SIP5 hom Verified 1.11303423423899 0.132846863392813 no 683 0.12319602525183 439 NA FT RESPONSE TO NUTRIENT LEVELS Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase; forms cytoplasmic foci upon DNA replication stress cellular response to glucose starvation molecular_function cytoplasm
YGR146C YGR146C ECL1 hom Verified 1.11299562241578 0.132855154793216 no 684 0.139734772888373 484 NA Protein of unknown function; mitochondrial-dependent role in the extension of chronological lifespan; overexpression increases oxygen consumption and respiratory activity while deletion results in reduced oxygen consumption under conditions of caloric restriction; induced by iron homeostasis transcription factor Aft2p; multicopy suppressor of temperature sensitive hsf1 mutant; induced by treatment with 8-methoxypsoralen and UVA irradiation biological_process molecular_function cellular_component
YBR108W YBR108W AIM3 hom Verified 1.10947999660124 0.133611584554989 no 685 0.124789084081032 464 NA FT CYTOSKELETON ORGANIZATION CYTOSKELETON Protein interacting with Rvs167p; null mutant is viable and displays elevated frequency of mitochondrial genome loss actin cortical patch assembly molecular_function membrane raft|actin cortical patch
YAL005C YAL005C SSA1 hom Verified 1.10874871392971 0.133769300282877 no 686 0.101523067723919 370 NA FT PROTEIN LOCALIZATION|TRANSLATION|MITOCHONDRION ORGANIZATION NUCLEUS ATPase involved in protein folding and NLS-directed nuclear transport; member of HSP70 family; forms chaperone complex with Ydj1p; localized to nucleus, cytoplasm, and cell wall; 98% identical with paralog Ssa2p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes; general targeting factor of Hsp104p to prion fibrils cytoplasmic translation|protein folding|protein refolding|protein targeting to mitochondrion|SRP-dependent cotranslational protein targeting to membrane, translocation|protein import into nucleus, translocation|response to stress unfolded protein binding|ATPase activity fungal-type vacuole membrane|fungal-type cell wall|plasma membrane|nucleus|polysome|chaperonin-containing T-complex|cytoplasm
YLR381W YLR381W CTF3 hom Verified 1.1086878285683 0.133782437196997 no 687 0.110993563905013 440 NA FT CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME KINETOCHORE Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p; may bind the kinetochore to spindle microtubules; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-I and fission yeast mis6 chromosome segregation|DNA replication initiation|establishment of mitotic sister chromatid cohesion molecular_function condensed nuclear chromosome kinetochore
YDR291W YDR291W HRQ1 hom Verified 1.10735305402867 0.134070657320794 no 688 0.122618007768403 435 NA FT NUCLEUS 3'-5'DNA helicase that has DNA strand annealing activity; helicase activity is stimulated by fork structure and 3'-tail length of substrates; belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity; similar to the human RecQ4p implicated in Rothmund-Thomson syndrome(RTS) biological_process molecular_function nucleus
YPR004C YPR004C AIM45 hom Verified 1.10683778567475 0.134182034135074 no 689 0.131602897484801 518 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-alpha; interacts with frataxin, Yfh1p; null mutant displays elevated frequency of mitochondrial genome loss; may have a role in oxidative stress response biological_process molecular_function mitochondrion
YDR436W YDR436W PPZ2 hom Verified 1.10631075118782 0.134296019965949 no 690 0.126954963791987 445 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance cellular sodium ion homeostasis protein serine/threonine phosphatase activity cellular_component
YLR303W YLR303W MET17 hom Verified 1.10560762870027 0.134448193222677 no 691 0.14289464196778 535 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Methionine and cysteine synthase (O-acetyl homoserine-O-acetyl serine sulfhydrylase), required for sulfur amino acid synthesis methionine metabolic process|cysteine biosynthetic process O-acetylhomoserine aminocarboxypropyltransferase activity|cysteine synthase activity plasma membrane|cytoplasm
YGL259W_p YGL259W YPS5 hom Uncharacterized 1.10469896975245 0.134645024990976 no 692 0.12179305438789 429 NA FT PROTEOLYSIS Protein with similarity to GPI-anchored aspartic proteases such as Yap1p and Yap3p biological_process aspartic-type endopeptidase activity cellular_component
YBR274W YBR274W CHK1 hom Verified 1.10412280741375 0.134769934459541 no 693 0.119702446254174 405 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION NUCLEUS Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase protein phosphorylation|replication fork protection|DNA damage checkpoint protein serine/threonine kinase activity nucleus
YLL059C_d YLL059C YLL059C hom Dubious 1.10324975641086 0.134959359569058 no 694 0.158904740870627 560 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDL123W YDL123W SNA4 hom Verified 1.10301486438466 0.135010355047243 no 695 0.149919494234095 429 NA Protein of unknown function, localized to the vacuolar outer membrane; predicted to be palmitoylated biological_process molecular_function fungal-type vacuole lumen|fungal-type vacuole membrane
YJR140C YJR140C HIR3 hom Verified 1.10227118896134 0.135171895457601 no 696 0.140912652077474 506 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION NUCLEUS Subunit of the HIR complex; a nucleosome assembly complex involved in regulation of histone gene transcription; involved in position-dependent gene silencing and nucleosome reassembly; ortholog of human CABIN1 protein DNA replication-independent nucleosome assembly|regulation of transcription involved in G1/S phase of mitotic cell cycle|transcription elongation from RNA polymerase II promoter nucleosome binding|DNA binding|transcription corepressor activity HIR complex|nucleus
YBR046C YBR046C ZTA1 hom Verified 1.10202039522554 0.135226402484399 no 697 0.139368141030889 474 NA FT OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS NUCLEUS NADPH-dependent quinone reductase, GFP-tagged protein localizes to the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin cellular response to oxidative stress NADPH:quinone reductase activity|AU-rich element binding|2-alkenal reductase [NAD(P)] activity nucleus|cytoplasm
YPL221W YPL221W FLC1 hom Verified 1.10193612246148 0.135244721546354 no 698 0.127090991431803 471 NA FT CELL WALL ORG/BIOGENESIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance protein folding|fungal-type cell wall biogenesis|FAD transport FAD transmembrane transporter activity integral to membrane|endoplasmic reticulum|fungal-type vacuole|cellular bud neck
YMR013W-A_d YMR013W-A YMR013W-A hom Dubious 1.10094819422501 0.135459602489371 no 699 0.124875493710586 438 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the characterized snoRNA gene snR73 Unknown Unknown Unknown
YOL001W YOL001W PHO80 hom Verified 1.1008150049474 0.135488589927703 no 700 0.169103825699115 654 NA FF|FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CELL CYCLE|SIGNALING|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS|RESPONSE TO NUTRIENT LEVELS NUCLEUS Cyclin, interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling negative regulation of phosphate metabolic process|regulation of cyclin-dependent protein kinase activity|negative regulation of calcium-mediated signaling|negative regulation of transcription from RNA polymerase II promoter|cellular metal ion homeostasis|regulation of protein localization|negative regulation of macroautophagy cyclin-dependent protein kinase regulator activity cyclin-dependent protein kinase holoenzyme complex|nucleus
YBR016W YBR016W YBR016W hom Verified 1.09907160631214 0.135868416812028 no 701 0.139738993008895 547 NA FT PLASMA MEMBRANE Tail-anchored plasma membrane protein with a conserved CYSTM module; predicted to be palmitoylated; has similarity to hydrophilins, which are involved in the adaptive response to hyperosmotic conditions; YBR016W has a paralog, YDL012C, that arose from the whole genome duplication biological_process molecular_function cellular bud membrane|plasma membrane|mating projection membrane
YMR190C YMR190C SGS1 hom Verified 1.09698229080866 0.136324566808628 no 702 0.128818701765356 485 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Nucleolar DNA helicase of the RecQ family; involved in genome integrity maintenance; regulates chromosome synapsis and meiotic joint molecule/crossover formation; potential role as repressor of a subset of rapamycin responsive genes; rapidly lost in response to rapamycin in Rrd1p-dependent manner; similar to human BLM and WRN proteins implicated in Bloom and Werner syndromes; forms nuclear foci upon DNA replication stress DNA double-strand break processing|meiotic DNA double-strand break processing|telomeric 3' overhang formation|meiotic chromosome segregation|DNA unwinding involved in replication|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint|telomere maintenance via recombination|replicative cell aging|DNA duplex unwinding|response to DNA damage stimulus|negative regulation of meiotic joint molecule formation|chromosome organization|regulation of reciprocal meiotic recombination|gene conversion at mating-type locus, DNA double-strand break processing|mitotic sister chromatid segregation ATP-dependent DNA helicase activity RecQ helicase-Topo III complex|nucleolus
YDL115C YDL115C IWR1 hom Verified 1.0962690060424 0.136480534409202 no 703 0.142215959893192 542 NA FT PROTEIN LOCALIZATION NUCLEUS RNA POL II, HOLOENZYME RNA polymerase II transport factor, conserved from yeast to humans; also has a role in transporting RNA polymerase III into the nucleus; interacts with most of the RNAP II subunits; nucleo-cytoplasmic shuttling protein; deletion causes hypersensitivity to K1 killer toxin; protein increases in abundance and relocalizes from nucleus to cytoplasm upon DNA replication stress cellular protein complex localization|nucleocytoplasmic transport protein binding nucleus|DNA-directed RNA polymerase II, holoenzyme|cytoplasm
YOR219C YOR219C STE13 hom Verified 1.0959339626788 0.136553837458094 no 704 0.143136932192261 488 NA FT PROTEOLYSIS GOLGI APPARATUS Dipeptidyl aminopeptidase, Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences, required for maturation of alpha factor, transcription is induced by a-factor peptide pheromone maturation aminopeptidase activity trans-Golgi network
YIL023C YIL023C YKE4 hom Verified 1.09395729336768 0.136986854496188 no 705 0.113264206202389 421 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Zinc transporter; localizes to the ER; null mutant is sensitive to calcofluor white, leads to zinc accumulation in cytosol; ortholog of the mouse KE4 and member of the ZIP (ZRT, IRT-like Protein) family zinc ion transport zinc ion transmembrane transporter activity integral to membrane|endoplasmic reticulum
YML018C YML018C YML018C hom Verified 1.09367453331619 0.137048873664568 no 706 0.138582423266956 498 NA Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; physical interaction with Atg27p suggests a possible role in autophagy; YML018C is not an essential gene; relative distribution to the vacuolar membrane decreases upon DNA replication stress; YML018C has a paralog, THI74, that arose from the whole genome duplication biological_process molecular_function fungal-type vacuole membrane|integral to membrane
YMR052C-A_d YMR052C-A YMR052C-A hom Dubious 1.09367253635786 0.137049311735584 no 707 0.135777553608701 524 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOR385W_p YOR385W YOR385W hom Uncharacterized 1.09366408083394 0.13705116662713 no 708 0.139275130377701 535 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YOR385W is not an essential gene biological_process molecular_function cytoplasm
YPL065W YPL065W VPS28 hom Verified 1.09312028756422 0.137170494792604 no 709 0.161471709628763 630 NA FF|FT PROTEIN LOCALIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p protein targeting to membrane|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein targeting to vacuole protein complex binding endosome|ESCRT I complex
YJR092W YJR092W BUD4 hom Verified 1.09051879234273 0.137742339927163 no 710 0.120742136589432 417 NA FT CELL CYCLE|CELL DIVISION SITE OF POLARIZED GROWTH|CYTOSKELETON Anillin-like protein involved in bud-site selection; required for the axial budding pattern; localizes with septins to the bud neck in mitosis and may constitute an axial landmark for the next round of budding; required for the formation and disassembly of the double septin ring structure, and generally for septin organization; in vivo substrate of Cdc28p/Clb2p cellular bud site selection|axial cellular bud site selection GTP binding cellular bud neck contractile ring
YLR295C YLR295C ATP14 hom Verified 1.09026139999529 0.13779900668464 no 711 0.167087327846345 563 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS MITOCHONDRION Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; protein abundance increases in response to DNA replication stress cristae formation|mitochondrial proton-transporting ATP synthase complex assembly|ATP synthesis coupled proton transport hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
YDR070C YDR070C FMP16 hom Verified 1.08986862886597 0.13788550869668 no 712 0.121282529613596 464 NA FT MITOCHONDRION Protein of unknown function; may be involved in responding to conditions of stress; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress biological_process molecular_function mitochondrion
YJR109C YJR109C CPA2 hom Verified 1.08971016719144 0.137920418013946 no 713 0.113565962252981 423 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Large subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor arginine biosynthetic process carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity carbamoyl-phosphate synthase complex
YEL045C_d YEL045C YEL045C hom Dubious 1.08833762235136 0.138223043736512 no 714 0.17565181784316 599 NA Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; deletion gives MMS sensitivity, growth defect under alkaline conditions, less than optimal growth upon citric acid stress Unknown Unknown Unknown
YIL135C YIL135C VHS2 hom Verified 1.08742451664858 0.138424620548888 no 715 0.105008092609004 415 NA FT CELL CYCLE Cytoplasmic protein of unknown function; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; similar to Mlf3p G1/S transition of mitotic cell cycle molecular_function cytoplasm
YNL323W YNL323W LEM3 hom Verified 1.08524326225066 0.138906963918255 no 716 0.235291554261356 831 NA FF|FT MEMBRANE ORGANIZATION|SIGNALING ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Membrane protein of the plasma membrane and ER, interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane phospholipid translocation|cell surface receptor signaling pathway phospholipid-translocating ATPase activity integral to membrane|endoplasmic reticulum|plasma membrane|cytoplasm
YIL054W_p YIL054W YIL054W hom Uncharacterized 1.08509390682247 0.138940032873293 no 717 0.142067228506224 506 NA Protein of unknown function; expressed at both mRNA and protein levels biological_process molecular_function cellular_component
YJR037W_d YJR037W YJR037W hom Dubious 1.08463256172433 0.139042213663644 no 718 0.119105795754194 393 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene HUL4/YJR036C; deletion mutant has decreased spore survival in Drosophila feces Unknown Unknown Unknown
YOR101W YOR101W RAS1 hom Verified 1.08402150680001 0.139177631591528 no 719 0.1052014783907 439 NA FT SIGNALING|NUCLEOTIDE METABOLISM PLASMA MEMBRANE GTPase involved in G-protein signaling in adenylate cyclase activation; plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes; relative distribution to the nucleus increases upon DNA replication stress adenylate cyclase-activating G-protein coupled receptor signaling pathway|replicative cell aging|Ras protein signal transduction GTPase activity plasma membrane
YNL229C YNL229C URE2 hom Verified 1.08377424980873 0.139232452540873 no 720 0.203222008129207 725 NA FF|FT PROTEIN LOCALIZATION Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion regulation of nitrogen utilization|response to aluminum ion|protein urmylation|cytoplasmic sequestering of transcription factor glutathione peroxidase activity|phosphoprotein binding|transcription corepressor activity cytosol
YHR191C YHR191C CTF8 hom Verified 1.0798422369716 0.140106219571537 no 721 0.181437263758289 604 NA FT CELL CYCLE|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion maintenance of DNA trinucleotide repeats|mitotic sister chromatid cohesion molecular_function Ctf18 RFC-like complex
YCR073W-A YCR073W-A SOL2 hom Verified 1.07890057394611 0.140316026484485 no 722 0.151878667445886 574 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|RNA LOCALIZATION|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL2 has a paralog, SOL1, that arose from the whole genome duplication tRNA export from nucleus molecular_function|6-phosphogluconolactonase activity cytosol|cytoplasm
YPR022C_p YPR022C YPR022C hom Uncharacterized 1.07887987963438 0.140320639668403 no 723 0.149974540380768 490 NA FT NUCLEUS Putative transcription factor, as suggested by computational analysis; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS biological_process sequence-specific DNA binding nucleus|cytoplasm
YDL063C YDL063C SYO1 hom Verified 1.07799674104271 0.140517605254029 no 724 0.162643725757069 557 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS NUCLEUS Transport adaptor or symportin; facilitates synchronized nuclear coimport of the two 5S-rRNA binding proteins Rpl5p and Rpl11p; required for biogenesis of the large ribosomal subunit; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus ribosomal large subunit biogenesis molecular_function nucleus|cytoplasm
YBR076W YBR076W ECM8 hom Verified 1.07756078634129 0.140614904990276 no 725 0.147760853090779 481 NA FT CELL WALL ORG/BIOGENESIS Non-essential protein of unknown function fungal-type cell wall organization molecular_function cellular_component
YPR024W YPR024W YME1 hom Verified 1.07200914748968 0.141857961751575 no 726 0.118844231218145 462 NA FT PROTEOLYSIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover chronological cell aging|misfolded or incompletely synthesized protein catabolic process|mitochondrion organization ATP-dependent peptidase activity mitochondrion|mitochondrial inner membrane|i-AAA complex
YLR037C YLR037C PAU23 hom Verified 1.06991906082054 0.142327871311239 no 727 0.142863186731764 513 NA FT CELL WALL ORG/BIOGENESIS Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth biological_process molecular_function fungal-type cell wall
YJL067W_d YJL067W YJL067W hom Dubious 1.06864377127351 0.142615108590352 no 728 0.122999969298557 430 NA Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGL060W YGL060W YBP2 hom Verified 1.06788667247005 0.1427858175204 no 729 0.147378007471474 586 NA FT CELL CYCLE NUCLEUS|CHROMOSOME KINETOCHORE Central kinetochore associated protein; mediates mitotic progression; interacts with several central kinetochore proteins and centromeric histone Cse4p; role in resistance to oxidative stress; similar to Slk19p; YBP2 has a paralog, YBP1, that arose from the whole genome duplication G2/M transition of mitotic cell cycle molecular_function condensed nuclear chromosome kinetochore|centromere-specific nucleosome|cytoplasm
YPL162C_p YPL162C YPL162C hom Uncharacterized 1.06761621750419 0.142846832566596 no 730 0.142294656351196 503 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of vacuole with cell cycle-correlated morphology biological_process molecular_function fungal-type vacuole membrane|integral to membrane
YDR277C YDR277C MTH1 hom Verified 1.06726036267267 0.142927140795044 no 731 0.133746808179716 420 NA FT SIGNALING Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation glucose transport|signal transduction molecular_function cellular_component
YPL042C YPL042C SSN3 hom Verified 1.06324489825139 0.143835453097792 no 732 0.184510666922315 641 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS NUCLEUS Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression phosphorylation of RNA polymerase II C-terminal domain|negative regulation of transcription from RNA polymerase II promoter|negative regulation of filamentous growth|protein phosphorylation|protein destabilization|nuclear-transcribed mRNA catabolic process, non-stop decay|positive regulation of transcription from RNA polymerase II promoter by galactose RNA polymerase II carboxy-terminal domain kinase activity|protein kinase activity|cyclin-dependent protein kinase activity mediator complex
YLR178C YLR178C TFS1 hom Verified 1.0623754845055 0.144032629318181 no 733 0.107632198478528 391 NA FT SIGNALING|PROTEOLYSIS Protein that interacts with and inhibits carboxypeptidase Y and Ira2p; phosphatidylethanolamine-binding protein (PEBP) family member; targets to vacuolar membranes during stationary phase; acetylated by NatB N-terminal acetyltransferase; protein abundance increases in response to DNA replication stress regulation of Ras protein signal transduction|regulation of proteolysis lipid binding|peptidase inhibitor activity|phospholipid binding fungal-type vacuole lumen|fungal-type vacuole membrane|cytoplasm
YHR105W YHR105W YPT35 hom Verified 1.06194268448924 0.144130852894622 no 734 0.130635233147411 482 NA Endosomal protein of unknown function that contains a phox (PX) homology domain and binds to both phosphatidylinositol-3-phosphate (PtdIns(3)P) and proteins involved in ER-Golgi or vesicular transport biological_process phosphatidylinositol-3-phosphate binding endosome
YOL103W YOL103W ITR2 hom Verified 1.0604172976105 0.144477398123285 no 735 0.14668369409753 505 NA FT PLASMA MEMBRANE Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively myo-inositol transport myo-inositol transmembrane transporter activity integral to membrane|plasma membrane|membrane
YMR154C YMR154C RIM13 hom Verified 1.05799691413038 0.145028424632695 no 736 0.151781169380547 592 NA FF|FT ION HOMEOSTASIS|PROTEOLYSIS|ION HOMEOSTASIS Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB protein processing cysteine-type endopeptidase activity cellular_component
YDR524C YDR524C AGE1 hom Verified 1.05748809566232 0.145144442379999 no 737 0.0779948082268231 322 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM GOLGI APPARATUS ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport phospholipid binding|ARF GTPase activator activity endosome|trans-Golgi network|cytoplasm
YDL169C YDL169C UGX2 hom Verified 1.05459428464304 0.145805459416625 no 738 0.143980217437066 525 NA Protein of unknown function, transcript accumulates in response to any combination of stress conditions biological_process molecular_function cellular_component
YJR128W_d YJR128W YJR128W hom Dubious 1.05332081256885 0.146096991651644 no 739 0.135666519378385 400 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSF2 Unknown Unknown Unknown
YOL011W YOL011W PLB3 hom Verified 1.05254978977141 0.146273689824175 no 740 0.126535161892444 461 NA FT LIPID METABOLISM PLASMA MEMBRANE Phospholipase B (lysophospholipase) involved in phospholipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro phosphatidylinositol metabolic process|phosphatidylserine catabolic process lysophospholipase activity extracellular region|plasma membrane
YDL191W YDL191W RPL35A hom Verified 1.05106968611843 0.146613292731076 no 741 0.147448092306288 575 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal 60S subunit protein L35A; homologous to mammalian ribosomal protein L35 and bacterial L29; RPL35A has a paralog, RPL35B, that arose from the whole genome duplication cytoplasmic translation|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic large ribosomal subunit|preribosome, large subunit precursor
YPL099C YPL099C AIM43 hom Verified 1.04946049339924 0.146983114437182 no 742 0.131163911668709 440 NA FT MITOCHONDRION Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss biological_process molecular_function mitochondrion
YMR172W YMR172W HOT1 hom Verified 1.04849924387933 0.14720432524085 no 743 0.12267068242991 458 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Transcription factor required for the transient induction of glycerol biosynthetic genes GPD1 and GPP2 in response to high osmolarity; targets Hog1p to osmostress responsive promoters; has similarity to Msn1p and Gcr1p cellular hyperosmotic salinity response|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly|sequence-specific DNA binding RNA polymerase II transcription factor activity nucleus
YLR386W YLR386W VAC14 hom Verified 1.04785019114543 0.147353816857719 no 744 0.186758807656141 666 NA FT PROTEIN LOCALIZATION|LIPID METABOLISM Protein involved in regulated synthesis of PtdIns(3,5)P(2), in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; interacts with Fig4p; activator of Fab1p phosphatidylinositol biosynthetic process|positive regulation of kinase activity protein binding, bridging fungal-type vacuole membrane|PAS complex|extrinsic to vacuolar membrane
YLR374C_d YLR374C YLR374C hom Dubious 1.04516633694484 0.1479730494128 no 745 0.203275425791912 698 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF STP3/YLR375W Unknown Unknown Unknown
YAL040C YAL040C CLN3 hom Verified 1.04468722360014 0.148083775855225 no 746 0.143405513655392 550 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION|PROTEIN PHOSPHORYLATION NUCLEUS G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote the G1 to S phase transition; plays a role in regulating transcription of the other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis vacuole organization|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|vacuole fusion, non-autophagic|regulation of cell size|G1/S transition of mitotic cell cycle cyclin-dependent protein kinase regulator activity nucleus
YHL024W YHL024W RIM4 hom Verified 1.04332013201783 0.148400025040471 no 747 0.169459450096259 563 NA FT CELL CYCLE Putative RNA-binding protein required for the expression of early and middle sporulation genes meiosis|reciprocal meiotic recombination|sporulation resulting in formation of a cellular spore|premeiotic DNA replication RNA binding cytoplasm
YGL072C_d YGL072C YGL072C hom Dubious 1.03910203480571 0.149378642359824 no 748 0.1871934462132 699 NA FF Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2 Unknown Unknown Unknown
YKL117W YKL117W SBA1 hom Verified 1.03897557447874 0.149408048081972 no 749 0.132945493595281 450 NA FT NUCLEUS Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins, and like p23 can regulate telomerase activity; protein abundance increases in response to DNA replication stress protein folding|positive regulation of telomere maintenance via telomerase|regulation of telomerase activity chaperone binding nucleus|cytoplasm
YAR030C_d YAR030C YAR030C hom Dubious 1.03793024368798 0.149651266020717 no 750 0.142130130638182 532 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YAR029W and the verified gene PRM9 Unknown Unknown Unknown
YBR027C_d YBR027C YBR027C hom Dubious 1.0376882094666 0.149707617956819 no 751 0.123628614983041 472 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR095C YLR095C IOC2 hom Verified 1.03738122805286 0.149779111670478 no 752 0.146824812682408 511 NA FT CHROMATIN ORGANIZATION NUCLEUS Member of a complex (Isw1b) with Isw1p and Ioc4p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PHD finger motif chromatin remodeling protein binding|nucleosome binding|ATPase activity|DNA binding ISW1 complex
YER068C-A_d YER068C-A YER068C-A hom Dubious 1.03701031613476 0.149865524706932 no 753 0.142695983495671 465 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPR123C_d YPR123C YPR123C hom Dubious 1.03501722125334 0.150330434382619 no 754 0.270362179166455 952 NA FF Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CTR Unknown Unknown Unknown
YNL053W YNL053W MSG5 hom Verified 1.03355631760981 0.150671814772857 no 755 0.160874118784168 550 NA FT PROTEIN LOCALIZATION|CELL CYCLE|SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION NUCLEUS Dual-specificity protein phosphatase; exists in 2 isoforms; required for maintenance of a low level of signaling through the cell integrity pathway, adaptive response to pheromone; regulates and is regulated by Slt2p; dephosphorylates Fus3p adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|regulation of fungal-type cell wall organization|inactivation of MAPK activity involved in cell wall biogenesis|regulation of MAPK export from nucleus|protein dephosphorylation|inactivation of MAPK activity involved in conjugation with cellular fusion protein tyrosine/serine/threonine phosphatase activity nucleus|cytoplasm
YOL087C YOL087C DUF1 hom Verified 1.03274596710033 0.150861397921799 no 756 0.218326582780055 727 NA Ubiquitin-binding protein of unknown function; contains one WD40 repeat in a beta-propeller fold; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; homolog of human WDR48/UAF1, which is involved in regulating the Fanconi anemia pathway; deletion mutant is sensitive to various chemicals including phenanthroline, sanguinarine, and nordihydroguaiaretic acid biological_process ubiquitin binding cytoplasm
YGL241W YGL241W KAP114 hom Verified 1.0321385011831 0.151003619898707 no 757 0.147852843461757 489 NA FT PROTEIN LOCALIZATION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS Karyopherin, responsible for nuclear import of specific proteins; cargoes include Spt15p, Sua7p, histones H2A and H2B, and Nap1p; amino terminus shows similarity to those of other importins, particularly Cse1p; localization is primarily nuclear; function is regulated by sumoylation; protein abundance increases in response to DNA replication stress protein import into nucleus|transcription factor import into nucleus protein transporter activity integral to membrane|nucleus|cytoplasm
YHR008C YHR008C SOD2 hom Verified 1.03180238909941 0.151082349928374 no 758 0.234516661617239 761 NA FF|FT OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS MITOCHONDRION Mitochondrial manganese superoxide dismutase, protects cells against oxygen toxicity; phosphorylated reactive oxygen species metabolic process|age-dependent response to oxidative stress involved in chronological cell aging|replicative cell aging|age-dependent response to reactive oxygen species involved in chronological cell aging superoxide dismutase activity mitochondrion|mitochondrial matrix
YOR096W YOR096W RPS7A hom Verified 1.03124950224539 0.15121191612948 no 759 0.187270623145149 620 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION NUCLEUS RIBOSOME Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7A has a paralog, RPS7B, that arose from the whole genome duplication cytoplasmic translation|ribosome biogenesis structural constituent of ribosome small-subunit processome|cytosolic small ribosomal subunit|90S preribosome
YNL069C YNL069C RPL16B hom Verified 1.03042856806674 0.151404434165781 no 760 0.178210951131652 643 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L16B; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16B has a paralog, RPL16A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YER075C YER075C PTP3 hom Verified 1.02861095127367 0.151831264877482 no 761 0.129843962808053 448 NA FT PROTEIN LOCALIZATION|SIGNALING|PROTEIN PHOSPHORYLATION NUCLEUS Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the cytoplasm inactivation of MAPK activity involved in osmosensory signaling pathway|regulation of sporulation|regulation of protein localization|protein dephosphorylation|inactivation of MAPK activity involved in conjugation with cellular fusion protein tyrosine phosphatase activity nucleus|cytoplasm
YBR180W YBR180W DTR1 hom Verified 1.02837421370882 0.151886916719492 no 762 0.147193612098616 481 NA FT CELL WALL ORG/BIOGENESIS Putative dityrosine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for spore wall synthesis; expressed during sporulation ascospore wall assembly|amine transport|transmembrane transport amine transmembrane transporter activity integral to membrane|prospore membrane
YFR008W YFR008W FAR7 hom Verified 1.02761254126301 0.152066061243761 no 763 0.157086345620765 594 NA FT CELL CYCLE|SIGNALING Protein involved in recovery from pheromone-induced cell cycle arrest; acts in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p; protein abundance increases in response to DNA replication stress re-entry into mitotic cell cycle after pheromone arrest molecular_function cellular_component
YOR155C YOR155C ISN1 hom Verified 1.02552898057619 0.152556829135641 no 764 0.148713957793135 473 NA FT NUCLEOTIDE METABOLISM Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms nicotinamide riboside biosynthetic process|inosine salvage|nicotinic acid riboside biosynthetic process IMP 5'-nucleotidase activity cellular_component
YDL234C YDL234C GYP7 hom Verified 1.02491943100141 0.152700602674367 no 765 0.118426904411919 401 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|NUCLEOTIDE METABOLISM GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking regulation of vacuole fusion, non-autophagic|vesicle-mediated transport Rab GTPase activator activity cytoplasm
YCR048W YCR048W ARE1 hom Verified 1.02226258456376 0.153328318372465 no 766 0.119045808374403 431 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the absence of oxygen; ARE1 has a paralog, ARE2, that arose from the whole genome duplication sterol metabolic process ergosterol O-acyltransferase activity|lanosterol O-acyltransferase activity integral to membrane|endoplasmic reticulum
YJR121W YJR121W ATP2 hom Verified 1.02130091342841 0.153555946899823 no 767 0.14800044044775 537 NA FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS MITOCHONDRION Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated ATP synthesis coupled proton transport hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism proton-transporting ATP synthase complex, catalytic core F(1)|mitochondrion|mitochondrial proton-transporting ATP synthase, catalytic core|integral to membrane
YMR278W YMR278W PGM3 hom Verified 1.02085323849512 0.153661988306125 no 768 0.131710773889442 509 NA FT CARBOHYDRATE METABOLISM NUCLEUS Phosphoglucomutase, catalyzes interconversion of glucose-1-phosphate and glucose-6-phospate; transcription induced in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; non-essential biological_process phosphoglucomutase activity nucleus|cytoplasm
YLR432W YLR432W IMD3 hom Verified 1.02038805532915 0.153772228266525 no 769 0.185841679494499 634 NA FT OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed GTP biosynthetic process IMP dehydrogenase activity plasma membrane|cytoplasm
YHR044C YHR044C DOG1 hom Verified 1.01924521246137 0.154043283514298 no 770 0.131408215239079 472 NA FT CARBOHYDRATE METABOLISM 2-deoxyglucose-6-phosphate phosphatase; paralogous to DOG2; member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed, in vivo substrate has not yet been identified glucose metabolic process 2-deoxyglucose-6-phosphatase activity cellular_component
YEL067C_p YEL067C YEL067C hom Uncharacterized 1.01882286369885 0.154143534580935 no 771 0.159230829032149 541 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YOR066W YOR066W MSA1 hom Verified 1.01689465537313 0.154601773070099 no 772 0.148478888501061 561 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE NUCLEUS Activator of G1-specific transcription factors, MBF and SBF; involved in regulation of the timing of G1-specific gene transcription and cell cycle initiation; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation G1/S transition of mitotic cell cycle|regulation of transcription involved in G1 phase of mitotic cell cycle|regulation of cell size molecular_function nucleus|cytoplasm
YHR126C_p YHR126C ANS1 hom Uncharacterized 1.01474946948142 0.155112633147749 no 773 0.152944247855784 525 NA FT PLASMA MEMBRANE Putative GPI protein; transcription dependent upon Azf1p biological_process molecular_function cellular_component
YGR262C YGR262C BUD32 hom Verified 1.01299999197409 0.155530082381316 no 774 0.187220190473027 541 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|LIPID METABOLISM|CELL DIVISION|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION NUCLEUS|CHROMOSOME Protein kinase, component of the EKC/KEOPS complex with Kae1p, Cgi121p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription threonylcarbamoyladenosine metabolic process|protein phosphorylation|telomere maintenance|cellular bud site selection|positive regulation of transcription from RNA polymerase II promoter protein serine/threonine kinase activity EKC/KEOPS complex|nucleus|cytoplasm
YIL009C-A YIL009C-A EST3 hom Verified 1.01201462782634 0.15576552970446 no 775 0.166615395407357 583 NA FT NUCLEUS|CHROMOSOME Component of the telomerase holoenzyme, involved in telomere replication telomere maintenance via telomerase ATP-dependent DNA/RNA helicase activity|GTPase activity|telomeric DNA binding chromosome, telomeric region|nucleus|telomerase holoenzyme complex
YER162C YER162C RAD4 hom Verified 1.01003008871188 0.156240437346814 no 776 0.155514941326179 582 NA FT RESPONSE TO DNA DAMAGE|PROTEOLYSIS NUCLEUS Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair; subunit of Nuclear Excision Repair Factor 2 (NEF2); also involved, with Rad23p, in turnover of ubiquitylated proteins proteasomal ubiquitin-dependent protein catabolic process|nucleotide-excision repair damaged DNA binding cytosol|nucleotide-excision repair factor 2 complex|nucleus
YLR221C YLR221C RSA3 hom Verified 1.00945047707208 0.156379320372964 no 777 0.147288223471636 484 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS NUCLEUS Protein with a likely role in ribosomal maturation, required for accumulation of wild-type levels of large (60S) ribosomal subunits; binds to the helicase Dbp6p in pre-60S ribosomal particles in the nucleolus ribosomal large subunit assembly molecular_function nucleolus|preribosome, large subunit precursor
YLR030W_p YLR030W YLR030W hom Uncharacterized 1.00942465891416 0.156385508654351 no 778 0.140112952710197 499 NA Putative protein of unknown function biological_process molecular_function cellular_component
YDR537C_d YDR537C YDR537C hom Dubious 1.00930354658639 0.156414539879048 no 779 0.152911521969605 528 NA Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W Unknown Unknown Unknown
YJR126C YJR126C VPS70 hom Verified 1.00696260666867 0.156976372019256 no 780 0.143648463211346 480 NA FT PROTEIN LOCALIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT Protein of unknown function involved in vacuolar protein sorting protein targeting to vacuole molecular_function cellular_component
YLR188W YLR188W MDL1 hom Verified 1.0065544113337 0.157074475803497 no 781 0.165524040033737 561 NA FT NUCLEOTIDE METABOLISM MITOCHONDRION Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, mediates export of peptides generated upon proteolysis of mitochondrial proteins, plays a role in the regulation of cellular resistance to oxidative stress oligopeptide transport|oligopeptide export from mitochondrion ATPase activity|oligopeptide-transporting ATPase activity mitochondrion|integral to membrane|mitochondrial inner membrane
YER183C YER183C FAU1 hom Verified 1.00565050303141 0.157291860441486 no 782 0.164086570981792 588 NA FT COFACTOR METABOLISM MITOCHONDRION 5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis folic acid-containing compound biosynthetic process 5-formyltetrahydrofolate cyclo-ligase activity mitochondrion
YPL199C_p YPL199C YPL199C hom Uncharacterized 1.00483885824175 0.157487224703515 no 783 0.158621020426836 564 NA Putative protein of unknown function, predicted to be palmitoylated biological_process molecular_function cytoplasm
YOR321W YOR321W PMT3 hom Verified 1.00430595661324 0.15761558170442 no 784 0.147039288104846 566 NA FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt5p, can instead interact with Pmt1p in some conditions; antifungal drug target; PMT3 has a paralog, PMT2, that arose from the whole genome duplication protein O-linked glycosylation|protein O-linked mannosylation dolichyl-phosphate-mannose-protein mannosyltransferase activity integral to membrane|dolichyl-phosphate-mannose-protein mannosyltransferase complex
YER186C_p YER186C YER186C hom Uncharacterized 1.00298977824812 0.157932896581805 no 785 0.157434315749535 553 NA Putative protein of unknown function biological_process molecular_function cellular_component
YMR062C YMR062C ARG7 hom Verified 1.00286920855892 0.157961985451078 no 786 0.198245588898239 694 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS MITOCHONDRION Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine fungal-type cell wall organization|ornithine biosynthetic process|arginine biosynthetic process acetyl-CoA:L-glutamate N-acetyltransferase activity|glutamate N-acetyltransferase activity mitochondrion|mitochondrial matrix
YLR460C_p YLR460C YLR460C hom Uncharacterized 1.00228578292613 0.158102793504932 no 787 0.145280022373342 525 NA FT OXIDATION-REDUCTION PROCESS Member of the quinone oxidoreductase family, up-regulated in response to the fungicide mancozeb; possibly up-regulated by iodine biological_process molecular_function cellular_component
YCL008C YCL008C STP22 hom Verified 1.00225832553008 0.158109422295706 no 788 0.186757166936773 674 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT PLASMA MEMBRANE Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype protein targeting to membrane|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|late endosome to vacuole transport|protein targeting to vacuole ubiquitin binding endosome|ESCRT I complex|internal side of plasma membrane
YPR018W YPR018W RLF2 hom Verified 1.00155742685707 0.15827869568583 no 789 0.151437333520607 535 NA FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1); chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription DNA replication-dependent nucleosome assembly histone binding chromosome, centromeric region|nucleus|CAF-1 complex
YOR131C YOR131C YOR131C hom Verified 0.997609600991054 0.159234351822141 no 790 0.174548334045994 605 NA FT NUCLEUS Putative haloacid dehalogenase-like hydrolase; non-essential gene; overexpression causes a cell cycle delay or arrest; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus|cytoplasm
YDR371W_p YDR371W CTS2 hom Uncharacterized 0.997411183986176 0.159282482457132 no 791 0.144237236536113 483 NA FT CARBOHYDRATE METABOLISM Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect sporulation resulting in formation of a cellular spore molecular_function cytoplasm
YGL134W YGL134W PCL10 hom Verified 0.997179846595552 0.159338610721385 no 792 0.126793949125442 469 NA FT CELL CYCLE|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|GEN. OF PRECURSOR METABOLITES AND ENERGY Pho85p cyclin; recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate negative regulation of glycogen biosynthetic process|regulation of cyclin-dependent protein kinase activity cyclin-dependent protein kinase regulator activity cyclin-dependent protein kinase holoenzyme complex
YLR331C_d YLR331C JIP3 hom Dubious 0.993840660517931 0.160150223617122 no 793 0.157771258197273 571 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2 Unknown Unknown Unknown
YPL225W YPL225W YPL225W hom Verified 0.993703681908558 0.160183574848026 no 794 0.176231367718396 637 NA Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress biological_process molecular_function ribosome|cytoplasm
YLL010C YLL010C PSR1 hom Verified 0.991655134638881 0.160682891981758 no 795 0.170422086707565 612 NA FT PLASMA MEMBRANE Plasma membrane associated protein phosphatase involved in the general stress response; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p response to stress phosphoprotein phosphatase activity plasma membrane
YHR179W YHR179W OYE2 hom Verified 0.991155917927558 0.160804725962031 no 796 0.164721361052469 601 NA FT OXIDATION-REDUCTION PROCESS NUCLEUS|MITOCHONDRION Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress apoptotic process NADPH dehydrogenase activity mitochondrion|nucleus|cytoplasm
YLR206W YLR206W ENT2 hom Verified 0.99090851178527 0.160865127847952 no 797 0.12100667801328 427 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus actin filament organization|endocytosis|actin cortical patch assembly clathrin binding mating projection tip|actin cortical patch
YNL115C_p YNL115C YNL115C hom Uncharacterized 0.989341958137388 0.161247930976027 no 798 0.147478469272738 545 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene biological_process molecular_function integral to membrane|fungal-type vacuole
YDR276C YDR276C PMP3 hom Verified 0.988956649705004 0.161342175943611 no 799 0.169955424316792 628 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential regulation of membrane potential|cation transport molecular_function plasma membrane
YMR004W YMR004W MVP1 hom Verified 0.987994036420942 0.161577784429882 no 800 0.178463067820318 594 NA FT PROTEIN LOCALIZATION|VACUOLAR TRANSPORT NUCLEUS Protein required for sorting proteins to the vacuole; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions; protein abundance increases in response to DNA replication stress protein targeting to vacuole phosphatidylinositol-3-phosphate binding nucleus|cytoplasm
YOR360C YOR360C PDE2 hom Verified 0.987383304284969 0.161727382994699 no 801 0.183228362818363 591 NA FT SIGNALING NUCLEUS High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon cAMP-mediated signaling 3',5'-cyclic-AMP phosphodiesterase activity nucleus|cytoplasm
YPL046C YPL046C ELC1 hom Verified 0.987267060421326 0.161755867099805 no 802 0.135386057033528 500 NA FT RESPONSE TO DNA DAMAGE|PROTEOLYSIS NUCLEUS UBIQUITIN LIGASE COMPLEX Elongin C, conserved among eukaryotes; forms a complex with Cul3p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; plays a role in global genomic repair global genome nucleotide-excision repair|protein ubiquitination involved in ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity elongin complex|Cul3-RING ubiquitin ligase complex
YBL029C-A YBL029C-A YBL029C-A hom Verified 0.986449674898779 0.161956249512938 no 803 0.164141437515998 536 NA FT PLASMA MEMBRANE Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; protein abundance increases in response to DNA replication stress; has potential orthologs in Saccharomyces species and in Yarrowia lipolytica biological_process molecular_function plasma membrane
YIL102C_p YIL102C YIL102C hom Uncharacterized 0.98640499088674 0.161967208477365 no 804 0.148463308416189 499 NA Putative protein of unknown function biological_process molecular_function cellular_component
YDR258C YDR258C HSP78 hom Verified 0.985898961527204 0.162091348270775 no 805 0.139316771623024 501 NA FT PROTEIN LOCALIZATION|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; able to prevent the aggregation of misfolded proteins as well as resolubilize protein aggregates positive regulation of mitochondrial translation in response to stress|protein refolding|protein stabilization|protein import into mitochondrial matrix|mitochondrial genome maintenance|protein unfolding|cellular response to heat misfolded protein binding|ATPase activity mitochondrion|mitochondrial matrix
YDL078C YDL078C MDH3 hom Verified 0.985767027708666 0.162123724631274 no 806 0.13067025153124 430 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM Peroxisomal malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle glyoxylate cycle|fatty acid beta-oxidation|malate metabolic process|NADH regeneration L-malate dehydrogenase activity|mRNA binding peroxisomal matrix|peroxisome
YOR061W YOR061W CKA2 hom Verified 0.984670732484586 0.16239291670156 no 807 0.18447765834596 705 NA FF|FT RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION NUCLEUS Alpha' catalytic subunit of casein kinase 2 (CK2); CK2 is a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; protein abundance increases in response to DNA replication stress; regulates Fkh1p-mediated donor preference during mating-type switching regulation of transcription from RNA polymerase I promoter|chronological cell aging|protein phosphorylation|regulation of transcription from RNA polymerase III promoter|response to DNA damage stimulus protein serine/threonine kinase activity protein kinase CK2 complex|UTP-C complex
YGL053W YGL053W PRM8 hom Verified 0.983748828531976 0.162619512558517 no 808 0.149648780031927 504 NA FT VESICLE-MEDIATED TRANSPORT ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Pheromone-regulated protein with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; forms a complex with Prp9p in the ER; member of DUP240 gene family biological_process molecular_function integral to membrane|endoplasmic reticulum|plasma membrane
YHR001W YHR001W OSH7 hom Verified 0.983727654293391 0.162624719414861 no 809 0.135016120835043 454 NA FT VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT ENDOPLASMIC RETICULUM Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability maintenance of cell polarity|endocytosis|exocytosis|sterol transport|sterol metabolic process|late endosome to vacuole transport lipid binding|oxysterol binding integral to membrane|cortical endoplasmic reticulum|cytoplasm
YIL159W YIL159W BNR1 hom Verified 0.982387460596765 0.162954500750605 no 810 0.157968924801242 548 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNI1 barbed-end actin filament capping|actin filament bundle assembly|formin-nucleated actin cable assembly profilin binding cellular bud neck
YDR163W YDR163W CWC15 hom Verified 0.980954669811452 0.16330754798026 no 811 0.156775258784223 557 NA FT RNA PROCESSING NUCLEUS Non-essential protein involved in pre-mRNA splicing, component of a complex containing Cef1p; has similarity to S. pombe Cwf15p mRNA splicing, via spliceosome molecular_function U2-type spliceosomal complex
YOL077W-A YOL077W-A ATP19 hom Verified 0.980887825967581 0.163324030780543 no 812 0.141807636657867 508 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS MITOCHONDRION Subunit k of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; associated only with the dimeric form of ATP synthase mitochondrial proton-transporting ATP synthase complex assembly|ATP synthesis coupled proton transport hydrogen ion transporting ATP synthase activity, rotational mechanism mitochondrion|mitochondrial proton-transporting ATP synthase complex|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
YDR451C YDR451C YHP1 hom Verified 0.979840193285277 0.163582504230038 no 813 0.222649123592079 798 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE NUCLEUS|CHROMOSOME Homeobox transcriptional repressor; binds Mcm1p and early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval; YHP1 has a paralog, YOX1, that arose from the whole genome duplication negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription involved in G1 phase of mitotic cell cycle RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription nuclear chromatin|nucleus
YKR040C_d YKR040C YKR040C hom Dubious 0.979414491315519 0.163687609887056 no 814 0.154403481995463 526 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YKR041W Unknown Unknown Unknown
YLR418C YLR418C CDC73 hom Verified 0.979134483436638 0.163756767624638 no 815 0.273009365983834 950 NA FF|FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION NUCLEUS|CHROMOSOME RNA POL II, HOLOENZYME Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; protein abundance increases in response to DNA replication stress transcription elongation from RNA polymerase I promoter|negative regulation of DNA recombination|mRNA 3'-end processing|recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex|positive regulation of transcription elongation from RNA polymerase II promoter|Unknown|regulation of transcription-coupled nucleotide-excision repair|transcription elongation from RNA polymerase II promoter chromatin binding|TFIIF-class binding transcription factor activity|RNA polymerase II core binding|RNA polymerase II transcription factor binding transcription factor activity nucleus|transcriptionally active chromatin|Cdc73/Paf1 complex
YDL121C_p YDL121C YDL121C hom Uncharacterized 0.978984899760255 0.163793720315583 no 816 0.139531708706571 434 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDL121C is not an essential protein biological_process molecular_function endoplasmic reticulum
YEL072W YEL072W RMD6 hom Verified 0.97821265039554 0.163984580509997 no 817 0.163255409870985 574 NA FT CELL CYCLE Protein required for sporulation biological_process molecular_function cellular_component
YNL066W YNL066W SUN4 hom Verified 0.976803709137068 0.16433316971405 no 818 0.174726173915506 576 NA FT CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|MITOCHONDRION ORGANIZATION MITOCHONDRION Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family mitochondrion organization glucosidase activity fungal-type cell wall|mitochondrial matrix
YKL110C YKL110C KTI12 hom Verified 0.976335549384237 0.164449104394838 no 819 0.181859586646013 653 NA FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p regulation of transcription from RNA polymerase II promoter|cell growth|tRNA wobble uridine modification chromatin binding nucleus|cytoplasm
YLR296W_d YLR296W YLR296W hom Dubious 0.976245375513633 0.164471441062892 no 820 0.163264491495258 567 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR374C_p YDR374C YDR374C hom Uncharacterized 0.975981791052798 0.164536743963435 no 821 0.137566338276707 470 NA Putative protein of unknown function biological_process molecular_function cellular_component
YCR004C YCR004C YCP4 hom Verified 0.975904032779888 0.16455601174077 no 822 0.154925579558073 511 NA FT OXIDATION-REDUCTION PROCESS MITOCHONDRION Protein of unknown function, has sequence and structural similarity to flavodoxins; predicted to be palmitoylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process electron carrier activity mitochondrion|membrane raft|plasma membrane|cytoplasm
YLR456W_p YLR456W YLR456W hom Uncharacterized 0.975335906094648 0.164696832621732 no 823 0.135373536531453 544 NA FT OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM NUCLEUS Putative pyridoxal 5'-phosphate synthase; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2; YLR456W has a paralog, YPR172W, that arose from the whole genome duplication biological_process molecular_function cellular_component
YPR185W YPR185W ATG13 hom Verified 0.974777083255032 0.16483542351527 no 824 0.150956132417846 536 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Regulatory subunit of the Atg1p signaling complex; stimulates Atg1p kinase activity; required for vesicle formation during autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; involved in Atg9p, Atg23p, and Atg27p cycling piecemeal microautophagy of nucleus|mitochondrion degradation|macroautophagy|activation of protein kinase activity|CVT pathway protein kinase regulator activity Atg1p signaling complex|extrinsic to membrane
YMR075C-A_d YMR075C-A YMR075C-A hom Dubious 0.974050862743373 0.1650156427128 no 825 0.160510604363766 537 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RCO1/YMR075W Unknown Unknown Unknown
YBL002W YBL002W HTB2 hom Verified 0.970089330325101 0.166000983440885 no 826 0.139472791353043 474 NA FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB1; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation chromatin assembly or disassembly DNA binding replication fork protection complex|nuclear nucleosome
YDL142C YDL142C CRD1 hom Verified 0.969207782002839 0.166220764556527 no 827 0.159364376946794 526 NA FT LIPID METABOLISM|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS MITOCHONDRION Cardiolipin synthase; produces cardiolipin, which is a phospholipid of the mitochondrial inner membrane that is required for normal mitochondrial membrane potential and function; also required for normal vacuolar ion homeostasis lipid biosynthetic process|cellular ion homeostasis|mitochondrial membrane organization cardiolipin synthase activity mitochondrion|integral to membrane
YHR156C YHR156C LIN1 hom Verified 0.969126345200132 0.166241077257635 no 828 0.168467205326235 585 NA FT NUCLEUS|CHROMOSOME Non-essential component of U5 snRNP; nuclear protein; physically interacts with Irr1p of cohesin complex; may link together proteins involved in chromosome segregation, mRNA splicing and DNA replication biological_process protein binding chromatin|nucleus|U4/U6 x U5 tri-snRNP complex|U5 snRNP
YNR021W_p YNR021W YNR021W hom Uncharacterized 0.968150468449121 0.166484613940988 no 829 0.152027530072398 483 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNR021W is not an essential gene biological_process molecular_function endoplasmic reticulum
YML080W YML080W DUS1 hom Verified 0.967942561147638 0.166536528369299 no 830 0.125677156149775 435 NA FT RNA PROCESSING|OXIDATION-REDUCTION PROCESS NUCLEUS Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNA(Phe) at U17 tRNA modification tRNA dihydrouridine synthase activity nucleus
YIL001W_p YIL001W YIL001W hom Uncharacterized 0.96715481847872 0.166733322410519 no 831 0.183233438465645 606 NA Putative protein of unknown function; contains a BTB/POZ domain which generally function in protein interactions; deletion slightly improved competitive fitness in rich media; GFP-tagged protein is localized to the cytoplasm biological_process molecular_function cytoplasm
YJR100C YJR100C AIM25 hom Verified 0.966859177261766 0.166807218271192 no 832 0.148673151020048 519 NA FT MITOCHONDRION Putative protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to murine NOR1; null mutant is viable and displays elevated frequency of mitochondrial genome loss biological_process molecular_function mitochondrion
YER091C-A_d YER091C-A YER091C-A hom Dubious 0.966550245914366 0.166884458586701 no 833 0.182934879281118 624 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOR270C YOR270C VPH1 hom Verified 0.965690198292172 0.167099612809285 no 834 0.171118497913631 577 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS Subunit a of vacuolar-ATPase V0 domain; one of two isoforms (Vph1p and Stv1p); Vph1p is located in V-ATPase complexes of the vacuole while Stv1p is located in V-ATPase complexes of the Golgi and endosomes; relative distribution to the vacuolar membrane decreases upon DNA replication stress polyphosphate metabolic process|proton transport|protein complex assembly|vacuolar acidification proton-transporting ATPase activity, rotational mechanism vacuolar proton-transporting V-type ATPase, V0 domain|fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YAL023C YAL023C PMT2 hom Verified 0.965580942438771 0.167126957649403 no 835 0.201970605708941 688 NA FT PROTEIN LOCALIZATION|CARBOHYDRATE METABOLISM|PROTEOLYSIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein O-mannosyltransferase of the ER membrane; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; involved in ER quality control; acts in a complex with Pmt1p, can instead interact with Pmt5p; antifungal drug target; PMT2 has a paralog, PMT3, that arose from the whole genome duplication ER-associated misfolded protein catabolic process|protein O-linked glycosylation|Unknown|protein exit from endoplasmic reticulum|protein O-linked mannosylation dolichyl-phosphate-mannose-protein mannosyltransferase activity integral to membrane|dolichyl-phosphate-mannose-protein mannosyltransferase complex
YMR026C YMR026C PEX12 hom Verified 0.963221646301993 0.167718152186184 no 836 0.189769773458133 609 NA FT PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION C3HC4-type RING-finger peroxin and E3 ubiquitin ligase, required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder protein import into peroxisome matrix ubiquitin-protein ligase activity|protein binding integral to peroxisomal membrane
YKR069W YKR069W MET1 hom Verified 0.96058389562832 0.168380714618017 no 837 0.168999415754091 575 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis siroheme biosynthetic process|methionine biosynthetic process|sulfate assimilation uroporphyrin-III C-methyltransferase activity intracellular
YIL056W YIL056W VHR1 hom Verified 0.960314616485522 0.168448447964892 no 838 0.132843989347181 449 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS NUCLEUS Transcriptional activator; required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations; VHR1 has a paralog, VHR2, that arose from the whole genome duplication regulation of transcription from RNA polymerase II promoter in response to biotin starvation|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity nucleus|cytoplasm
YOR005C YOR005C DNL4 hom Verified 0.959149971441746 0.168741599617385 no 839 0.149499282316731 508 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION NUCLEUS|CHROMOSOME DNA ligase required for nonhomologous end-joining (NHEJ), forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth double-strand break repair via nonhomologous end joining|replicative cell aging DNA ligase (ATP) activity DNA ligase IV complex|nuclear chromatin
YLL025W YLL025W PAU17 hom Verified 0.958742472283653 0.168844248207109 no 840 0.136557404753688 462 NA Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; YLL025W is not an essential gene biological_process molecular_function cellular_component
YJR129C_p YJR129C YJR129C hom Uncharacterized 0.958505261276204 0.16890401986973 no 841 0.152240283114234 547 NA Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm biological_process S-adenosylmethionine-dependent methyltransferase activity cytoplasm
YJR050W YJR050W ISY1 hom Verified 0.958392898094271 0.168932337524922 no 842 0.19300381682157 633 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING NUCLEUS Member of NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of spliceosome containing U2, U5, and U6 snRNAs, interacts with Prp16p to modulate splicing fidelity; isy1 syf2 cells have defective spindles generation of catalytic spliceosome for second transesterification step|mRNA 3'-splice site recognition first spliceosomal transesterification activity|second spliceosomal transesterification activity post-spliceosomal complex|Prp19 complex|post-mRNA release spliceosomal complex|U2-type catalytic step 2 spliceosome|U2-type catalytic step 1 spliceosome
YOR231W YOR231W MKK1 hom Verified 0.95825640174596 0.168966741298706 no 843 0.16657919851026 591 NA FT SIGNALING|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION SITE OF POLARIZED GROWTH MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication signal transduction|peroxisome degradation|protein phosphorylation protein kinase activity|MAP kinase kinase activity cellular bud tip
YPR114W_p YPR114W YPR114W hom Uncharacterized 0.957662499344315 0.169116486218226 no 844 0.17913902202128 621 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Putative protein of unknown function biological_process molecular_function integral to membrane|endoplasmic reticulum
YBR067C YBR067C TIP1 hom Verified 0.957448503781125 0.169170463350442 no 845 0.161367123266086 565 NA FT CELL WALL ORG/BIOGENESIS Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins fungal-type cell wall organization structural constituent of cell wall|lipase activity fungal-type cell wall
YDL066W YDL066W IDP1 hom Verified 0.953335360308246 0.170210090464641 no 846 0.256042967451882 901 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes isocitrate metabolic process|glutamate biosynthetic process isocitrate dehydrogenase (NADP+) activity mitochondrial nucleoid|mitochondrion
YGL223C YGL223C COG1 hom Verified 0.953074306726394 0.170276211532287 no 847 0.229351881497864 753 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments retrograde transport, vesicle recycling within Golgi|intra-Golgi vesicle-mediated transport|CVT pathway molecular_function Golgi transport complex
YJR010C-A YJR010C-A SPC1 hom Verified 0.952747262221387 0.170359070356572 no 848 0.173179102387172 617 NA FT PROTEIN LOCALIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Subunit of the signal peptidase complex (SPC); SPC cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER); homolog of the SPC12 subunit of mammalian signal peptidase complex; protein abundance increases in response to DNA replication stress signal peptide processing|protein targeting to ER molecular_function signal peptidase complex
YLR341W YLR341W SPO77 hom Verified 0.952327678811596 0.170465412321675 no 849 0.174878319056264 579 NA FT CELL WALL ORG/BIOGENESIS Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis ascospore wall assembly|ascospore formation molecular_function intracellular
YGR276C YGR276C RNH70 hom Verified 0.95035798909912 0.170965191401562 no 850 0.167716931159821 559 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS 3'-5' exoribonuclease; required for maturation of 3' ends of 5S rRNA and tRNA-Arg3 from dicistronic transcripts U5 snRNA 3'-end processing|generation of mature 3'-end of 5S rRNA generated by RNA polymerase III|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|tRNA 3'-trailer cleavage, exonucleolytic 3'-5'-exoribonuclease activity|3'-5' exonuclease activity nucleus
YJR069C YJR069C HAM1 hom Verified 0.949899720985883 0.171081604313712 no 851 0.152335449757819 526 NA FT NUCLEOTIDE METABOLISM NUCLEUS Nucleoside triphosphate pyrophosphohydrolase; active against a wide range of substrates including ITP, dITP and XTP; mediates exclusion of noncanonical purines and pyrimadines from deoxyribonucleoside triphosphate pools; mutant is sensitive to the base analog 6-N-hydroxylaminopurine; protein abundance increases in response to DNA replication stress purine deoxyribonucleoside triphosphate catabolic process|pyrimidine deoxyribonucleoside triphosphate catabolic process dITP diphosphatase activity|ITP diphosphatase activity|XTP diphosphatase activity|dCTP diphosphatase activity|UTP diphosphatase activity|dTTP diphosphatase activity|dATP pyrophosphohydrolase activity|dGTP diphosphatase activity|dUTP diphosphatase activity|GTP diphosphatase activity nucleus|cytoplasm
YGR087C YGR087C PDC6 hom Verified 0.949413455632136 0.171205184733712 no 852 0.168248007809361 573 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation L-phenylalanine catabolic process|ethanol metabolic process|tryptophan catabolic process|aromatic amino acid family catabolic process to alcohol via Ehrlich pathway pyruvate decarboxylase activity cytoplasm
YPL001W YPL001W HAT1 hom Verified 0.947677054224651 0.171646942856101 no 853 0.188934104051001 639 NA FT CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING NUCLEUS HISTONE ACETYLTRANSFERASE Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A, to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair histone acetylation|chromatin silencing at telomere histone acetyltransferase activity|histone binding histone acetyltransferase complex|nucleus|cytoplasm
YCR100C_p YCR100C YCR100C hom Uncharacterized 0.946670097422723 0.17190345616892 no 854 0.196008768053859 662 NA Putative protein of unknown function biological_process molecular_function integral to membrane
YJL084C YJL084C ALY2 hom Verified 0.945663357029684 0.172160158914027 no 855 0.152340301347031 570 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION Alpha arrestin that controls nutrient-mediated intracellular sorting of permease Gap1p; interacts with AP-1 subunit Apl4p; phosphorylated by Npr1p and also by cyclin-CDK complex Pcl7p-Pho85p; promotes endocytosis of plasma membrane proteins; ALY2 has a paralog, ALY1, that arose from the whole genome duplication Unknown|regulation of intracellular transport|ubiquitin-dependent endocytosis protein binding, bridging|ubiquitin protein ligase binding late endosome|cytoplasm|early endosome
YKL127W YKL127W PGM1 hom Verified 0.94404760556659 0.172572660868765 no 856 0.139471179145824 492 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism glucose 6-phosphate metabolic process|galactose catabolic process|glucose 1-phosphate metabolic process|UDP-glucose metabolic process|trehalose biosynthetic process|glycogen biosynthetic process phosphoglucomutase activity cytoplasm
YOR374W YOR374W ALD4 hom Verified 0.943828190541092 0.172628726170786 no 857 0.158445452196192 547 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM MITOCHONDRION Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed NADPH regeneration|ethanol metabolic process|pyruvate metabolic process|acetate biosynthetic process aldehyde dehydrogenase [NAD(P)+] activity|aldehyde dehydrogenase (NAD) activity mitochondrial nucleoid|mitochondrion
YLR328W YLR328W NMA1 hom Verified 0.942471499348891 0.172975648080548 no 858 0.20607641918067 614 NA FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM NUCLEUS Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways; NMA1 has a paralog, NMA2, that arose from the whole genome duplication NAD biosynthetic process nicotinamide-nucleotide adenylyltransferase activity nucleus|cytoplasm
YDR517W YDR517W GRH1 hom Verified 0.940506796942591 0.173478832431653 no 859 0.149740902412531 527 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Acetylated cis-Golgi protein, involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes; protein abundance increases in response to DNA replication stress protein secretion|ER to Golgi vesicle-mediated transport|Golgi organization molecular_function COPII vesicle coat|cis-Golgi network|cytoplasm
YNL034W_p YNL034W YNL034W hom Uncharacterized 0.94006833898752 0.173591253912992 no 860 0.165049506112966 578 NA Putative protein of unknown function; YNL034W is not an essential gene biological_process molecular_function cellular_component
YOL023W YOL023W IFM1 hom Verified 0.939869522692374 0.173642246074732 no 861 0.200589425965107 706 NA FT TRANSLATION|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial translation initiation factor 2 translational initiation|mitochondrial translational initiation|mitochondrial translation tRNA binding|GTPase activity|translation initiation factor activity mitochondrion
YGL012W YGL012W ERG4 hom Verified 0.939452860858547 0.173749141907102 no 862 0.299828521995583 1048 NA FF|FT LIPID METABOLISM|OXIDATION-REDUCTION PROCESS ENDOPLASMIC RETICULUM C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol ergosterol biosynthetic process delta24(24-1) sterol reductase activity integral to membrane|endoplasmic reticulum
YLL006W-A_p YLL006W-A YLL006W-A hom Uncharacterized 0.93851417692803 0.173990117404652 no 863 0.143866162057873 510 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YOL052C-A YOL052C-A DDR2 hom Verified 0.936510111276914 0.174505304516199 no 864 0.175010086382349 597 NA Multi-stress response protein; expression is activated by a variety of xenobiotic agents and environmental or physiological stresses; DDR2 has a paralog, HOR7, that arose from the whole genome duplication response to stress molecular_function fungal-type vacuole|cytoplasm
YGR240C YGR240C PFK1 hom Verified 0.93570994898949 0.174711273385117 no 865 0.209954782204774 756 NA FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Alpha subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes proton transport|glycolysis 6-phosphofructokinase activity mitochondrion|6-phosphofructokinase complex|cytoplasm
YPR005C YPR005C HAL1 hom Verified 0.935213581427629 0.174839120330959 no 866 0.179936184436113 632 NA FT TRANSCRIPTION FROM RNA POL II Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p response to salt stress|positive regulation of transcription from RNA polymerase II promoter molecular_function cytoplasm
YNL141W YNL141W AAH1 hom Verified 0.934949987274498 0.17490703710988 no 867 0.175118373185269 640 NA FT NUCLEOTIDE METABOLISM NUCLEUS Adenine deaminase (adenine aminohydrolase), converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome adenine catabolic process|hypoxanthine salvage|purine-containing compound salvage adenine deaminase activity nucleus|cytoplasm
YDR123C YDR123C INO2 hom Verified 0.934302265554572 0.175073998005336 no 868 0.185828338327054 656 NA FT TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM NUCLEUS Component of the heteromeric Ino2p/Ino4p basic helix-loop-helix transcription activator that binds inositol/choline-responsive elements (ICREs), required for derepression of phospholipid biosynthetic genes in response to inositol depletion phospholipid biosynthetic process|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YCR105W YCR105W ADH7 hom Verified 0.930870091946754 0.175960383504672 no 869 0.200402838995979 643 NA FT OXIDATION-REDUCTION PROCESS NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance alcohol metabolic process alcohol dehydrogenase (NADP+) activity cellular_component
YOR161C-C_p YOR161C-C YOR161C-C hom Uncharacterized 0.930468952150177 0.176064166130212 no 870 0.150860548576208 509 NA Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YJL077W-B_p YJL077W-B YJL077W-B hom Uncharacterized 0.928149684440503 0.176664965050993 no 871 0.223186840197015 725 NA Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YBR033W_p YBR033W EDS1 hom Uncharacterized 0.927556903431088 0.176818730846328 no 872 0.166347617080971 614 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Putative zinc cluster protein, predicted to be a transcription factor; not an essential gene; EDS1 has a paralog, RGT1, that arose from the whole genome duplication biological_process sequence-specific DNA binding cellular_component
YLR406C-A_p YLR406C-A YLR406C-A hom Uncharacterized 0.927215450946745 0.176907341087213 no 873 0.180233444919375 612 NA Putative protein of unknown function biological_process molecular_function cellular_component
YHL025W YHL025W SNF6 hom Verified 0.926515900553162 0.17708896884528 no 874 0.18663743759332 541 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CARBOHYDRATE METABOLISM NUCLEUS RSC COMPLEX Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf5p; relocates to the cytosol under hypoxic conditions sucrose catabolic process|nucleotide-excision repair|chromatin remodeling|positive regulation of transcription from RNA polymerase II promoter molecular_function SWI/SNF complex|nucleus
YNL325C YNL325C FIG4 hom Verified 0.926301959341929 0.177144538983645 no 875 0.191955712953213 650 NA FT LIPID METABOLISM Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase; required for efficient mating and response to osmotic shock; physically associates with and regulated by Vac14p; contains a SAC1-like domain phosphatidylinositol dephosphorylation phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity fungal-type vacuole membrane|PAS complex|extrinsic to membrane
YLR455W YLR455W YLR455W hom Verified 0.925368469256926 0.177387137136178 no 876 0.193461492522141 682 NA FT NUCLEUS Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus
YDL083C YDL083C RPS16B hom Verified 0.924621313607881 0.177581461203942 no 877 0.205556897319716 668 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16B has a paralog, RPS16A, that arose from the whole genome duplication cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit
YER091C YER091C MET6 hom Verified 0.923941444785065 0.177758401665739 no 878 0.109926310900869 383 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Cobalamin-independent methionine synthase, involved in methionine biosynthesis and regeneration; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs methionine biosynthetic process 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity plasma membrane|cytoplasm
YDR386W YDR386W MUS81 hom Verified 0.920960523076883 0.178535518987669 no 879 0.225030140822512 775 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p DNA repair|DNA topological change|reciprocal meiotic recombination|resolution of meiotic recombination intermediates|response to DNA damage stimulus crossover junction endodeoxyribonuclease activity|endonuclease activity Holliday junction resolvase complex|nucleus
YOL118C_d YOL118C YOL118C hom Dubious 0.92033833231919 0.178697991772551 no 880 0.195352283357727 643 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YER019W YER019W ISC1 hom Verified 0.918713508135085 0.179122721225673 no 881 0.189173706547899 686 NA FT LIPID METABOLISM ENDOPLASMIC RETICULUM|MITOCHONDRION Mitochondrial membrane localized inositol phosphosphingolipid phospholipase C, hydrolyzes complex sphingolipids to produce ceramide; activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol; mediates Na+ and Li+ halotolerance response to salt stress|ceramide biosynthetic process|sphingolipid catabolic process inositol phosphosphingolipid phospholipase activity mitochondrion|endoplasmic reticulum|integral to mitochondrial outer membrane
YGL200C YGL200C EMP24 hom Verified 0.917355928004463 0.179478079555817 no 882 0.185324106254071 657 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles protein retention in ER lumen|vesicle organization|ER to Golgi vesicle-mediated transport molecular_function integral to membrane|endoplasmic reticulum|ER to Golgi transport vesicle
YJL046W YJL046W AIM22 hom Verified 0.917058853800391 0.179555900353682 no 883 0.178038218822018 597 NA FT MITOCHONDRION Putative lipoate-protein ligase, required along with Lip2 and Lip5 for lipoylation of Lat1p and Kgd2p; similar to E. coli LplA; null mutant displays reduced frequency of mitochondrial genome loss protein lipoylation lipoate-protein ligase activity mitochondrion
YMR252C_p YMR252C YMR252C hom Uncharacterized 0.916935797031429 0.179588142200662 no 884 0.160992852179054 590 NA FT MITOCHONDRION Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YMR252C is not an essential gene biological_process molecular_function mitochondrion
YHR041C YHR041C SRB2 hom Verified 0.916278522323961 0.179760414985079 no 885 0.228765719152984 771 NA FT TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|RESPONSE TO NUTRIENT LEVELS NUCLEUS RNA POL II, HOLOENZYME Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to chemical stimulus|RNA polymerase II transcriptional preinitiation complex assembly|negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to nutrient levels|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly|core RNA polymerase II binding transcription factor activity|RNA polymerase II transcription factor recruiting transcription factor activity|TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly|protein domain specific binding core mediator complex
YJL191W YJL191W RPS14B hom Verified 0.915921008400964 0.17985416355239 no 886 0.195259871765791 683 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION NUCLEUS RIBOSOME Protein component of the small (40S) ribosomal subunit; required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; homologous to mammalian ribosomal protein S14 and bacterial S11; RPS14B has a paralog, RPS14A, that arose from the whole genome duplication cytoplasmic translation|ribosomal small subunit assembly|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome|SSU rRNA binding small-subunit processome|cytosolic small ribosomal subunit
YLR387C YLR387C REH1 hom Verified 0.915457704938027 0.179975698302775 no 887 0.214535896569311 716 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS RIBOSOME Cytoplasmic 60S subunit biogenesis factor, associates with pre-60S particles; similar to Rei1p and shares partially redundant function in cytoplasmic 60S subunit maturation; contains dispersed C2H2 zinc finger domains ribosomal large subunit biogenesis|budding cell bud growth molecular_function cytosolic large ribosomal subunit|preribosome, large subunit precursor|cytoplasm
YOR350C YOR350C MNE1 hom Verified 0.915163675015297 0.180052855601353 no 888 0.182817265620125 627 NA FT RNA PROCESSING MITOCHONDRION Mitochondrial matrix protein involved in splicing Group I aI5-beta intron from COX1 mRNA Group I intron splicing molecular_function mitochondrion|ribonucleoprotein complex|mitochondrial matrix
YLR421C YLR421C RPN13 hom Verified 0.913449152598003 0.180503182240614 no 889 0.190025924339358 669 NA FT PROTEOLYSIS NUCLEUS Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; protein abundance increases in response to DNA replication stress ubiquitin-dependent protein catabolic process ubiquitin binding proteasome storage granule|proteasome regulatory particle, lid subcomplex
YDR370C YDR370C DXO1 hom Verified 0.912750313150526 0.180686937898586 no 890 0.175003724656509 574 NA Protein with decapping and 5′-3′ exoRNase activity; similar to Rai1p biological_process molecular_function cytoplasm
YAL060W YAL060W BDH1 hom Verified 0.911311881413388 0.181065533953588 no 891 0.189393855004017 625 NA FT OXIDATION-REDUCTION PROCESS NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source alcohol metabolic process|butanediol biosynthetic process (R,R)-butanediol dehydrogenase activity cytoplasm
YHR195W YHR195W NVJ1 hom Verified 0.911000130294532 0.181147652509435 no 892 0.195740726433565 701 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|NUCLEUS Nuclear envelope protein, anchored to the nuclear inner membrane, that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN) microautophagy|cellular protein localization protein binding nuclear envelope
YJL172W YJL172W CPS1 hom Verified 0.905814946683005 0.182516904222942 no 893 0.202674668534095 621 NA FT PROTEOLYSIS Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions nitrogen compound metabolic process|proteolysis involved in cellular protein catabolic process carboxypeptidase activity fungal-type vacuole lumen
YHR154W YHR154W RTT107 hom Verified 0.904281992308645 0.182922946465185 no 894 0.212604759032826 728 NA FT RESPONSE TO DNA DAMAGE NUCLEUS UBIQUITIN LIGASE COMPLEX Protein implicated in Mms22-dependent DNA repair during S phase; involved in recruiting the SMC5/6 complex to double-strand breaks; DNA damage induces phosphorylation by Mec1p at one or more SQ/TQ motifs; interacts with Mms22p and Slx4p; has four BRCT domains; has a role in regulation of Ty1 transposition; relative distribution to nuclear foci increases upon DNA replication stress negative regulation of transposition, RNA-mediated|double-strand break repair molecular_function Cul8-RING ubiquitin ligase complex|nucleus
YPL022W YPL022W RAD1 hom Verified 0.904125199256305 0.182964508876855 no 895 0.182389785089366 619 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein mitotic recombination|meiotic mismatch repair|nucleotide-excision repair, DNA incision, 5'-to lesion|double-strand break repair via single-strand annealing, removal of nonhomologous ends|removal of nonhomologous ends single-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity nucleotide-excision repair factor 1 complex|nucleus
YPR120C YPR120C CLB5 hom Verified 0.902767785724212 0.183324575840269 no 896 0.203372323575217 683 NA FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION NUCLEUS B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase spindle assembly|G1/S transition of mitotic cell cycle|regulation of S phase of mitotic cell cycle|G2/M transition of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|positive regulation of spindle pole body separation|premeiotic DNA replication|positive regulation of DNA replication cyclin-dependent protein kinase regulator activity nucleus
YER007W YER007W PAC2 hom Verified 0.901975810145933 0.183534858912686 no 897 0.184002560200778 649 NA FT CYTOSKELETON Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl protein folding|tubulin complex assembly|tubulin complex biogenesis alpha-tubulin binding cellular_component
YGR021W_p YGR021W YGR021W hom Uncharacterized 0.901801888426048 0.183581058230433 no 898 0.194095838913977 669 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YCR025C_d YCR025C YCR025C hom Dubious 0.901577462590787 0.183640683807555 no 899 0.197565080118899 722 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR025C is not an essential gene Unknown Unknown Unknown
YDR143C YDR143C SAN1 hom Verified 0.90046732919468 0.183935802092515 no 900 0.182878878516734 566 NA FT PROTEOLYSIS NUCLEUS Ubiquitin-protein ligase; involved in the proteasome-dependent degradation of aberrant nuclear proteins; targets substrates with regions of exposed hydrophobicity containing 5 or more contiguous hydrophobic residues; contains intrinsically disordered regions that contribute to substrate recognition nucleus-associated proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to misfolded protein|response to stress ubiquitin-protein ligase activity nucleus|cytoplasm
YDL231C YDL231C BRE4 hom Verified 0.899190932956896 0.184275484528109 no 901 0.188248232288663 625 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION Zinc finger protein containing five transmembrane domains; null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect intracellular transport endocytosis molecular_function integral to membrane
YBR279W YBR279W PAF1 hom Verified 0.899120748236481 0.184294173834011 no 902 0.2606494613864 912 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|GENE SILENCING NUCLEUS|CHROMOSOME RNA POL II, HOLOENZYME Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cell cycle-regulated genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; homolog of human PD2/hPAF1 negative regulation of DNA recombination|mRNA 3'-end processing|snoRNA transcription from an RNA polymerase II promoter|regulation of transcription by chromatin organization|transcription from RNA polymerase I promoter|regulation of transcription-coupled nucleotide-excision repair|rRNA processing|transcription elongation from RNA polymerase I promoter|regulation of chromatin silencing at telomere|regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of histone H3-K4 methylation|negative regulation of transcription from RNA polymerase II promoter|global genome nucleotide-excision repair|chromatin silencing at rDNA|Unknown|snoRNA 3'-end processing|transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|chromatin binding|TFIIF-class binding transcription factor activity|RNA polymerase II core binding|RNA polymerase II transcription factor binding transcription factor activity transcriptionally active chromatin|nucleus|Cdc73/Paf1 complex
YLR201C YLR201C COQ9 hom Verified 0.899034619781342 0.184317110367129 no 903 0.176178860207919 601 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes ubiquinone biosynthetic process|aerobic respiration molecular_function mitochondrion|mitochondrial inner membrane
YDR347W YDR347W MRP1 hom Verified 0.895747769842474 0.185193745460424 no 904 0.197106581100313 674 NA FT TRANSLATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit mitochondrial ribosomal protein mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YNL276C_d YNL276C YNL276C hom Dubious 0.893418333516828 0.185816594140668 no 905 0.18485698949118 615 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene MET2/YNL277W Unknown Unknown Unknown
YLR248W YLR248W RCK2 hom Verified 0.892814945940368 0.185978140561189 no 906 0.192864466785706 645 NA FT CELL CYCLE|SIGNALING|PROTEIN PHOSPHORYLATION|RESPONSE TO OXIDATIVE STRESS Protein kinase involved in response to oxidative and osmotic stress; identified as suppressor of S. pombe cell cycle checkpoint mutations; similar to CaM (calmodulin) kinases; RCK2 has a paralog, RCK1, that arose from the whole genome duplication cellular response to oxidative stress|protein phosphorylation|osmosensory signaling pathway|regulation of meiosis protein serine/threonine kinase activity|protein kinase activity cytoplasm
YOR285W YOR285W RDL1 hom Verified 0.892376846811378 0.186095488452713 no 907 0.172296567658153 586 NA FT ENDOPLASMIC RETICULUM|MITOCHONDRION Protein of unknown function containing a rhodanese-like domain; localized to the mitochondrial outer membrane; protein abundance increases in response to DNA replication stress biological_process molecular_function mitochondrial outer membrane|mitochondrion|endoplasmic reticulum
YDR073W YDR073W SNF11 hom Verified 0.891900211125362 0.186223210746289 no 908 0.164885457354747 569 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS RSC COMPLEX Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p; relocates to the cytosol under hypoxic conditions positive regulation of transcription from RNA polymerase II promoter molecular_function SWI/SNF complex
YBL065W_d YBL065W YBL065W hom Dubious 0.891743993341068 0.186265083662317 no 909 0.200820913049945 627 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene Unknown Unknown Unknown
YBR145W YBR145W ADH5 hom Verified 0.890616581138463 0.186567450357412 no 910 0.186304772123071 612 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM NUCLEUS Alcohol dehydrogenase isoenzyme V; involved in ethanol production; ADH5 has a paralog, ADH1, that arose from the whole genome duplication NADH oxidation|ethanol biosynthetic process involved in glucose fermentation to ethanol|amino acid catabolic process to alcohol via Ehrlich pathway alcohol dehydrogenase (NAD) activity nucleus|cytoplasm
YJL036W YJL036W SNX4 hom Verified 0.890406059778631 0.186623944862613 no 911 0.226150953154107 787 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT Sorting nexin, involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX phosphoinositide-binding domain; forms complexes with Snx41p and with Atg20p piecemeal microautophagy of nucleus|mitochondrion degradation|early endosome to Golgi transport|CVT pathway|protein targeting to vacuole phosphatidylinositol-3-phosphate binding cytosol|pre-autophagosomal structure|extrinsic to membrane|early endosome
YGL254W YGL254W FZF1 hom Verified 0.890298953417897 0.186652691478154 no 912 0.195550644648426 641 NA FT TRANSCRIPTION FROM RNA POL II|ION HOMEOSTASIS|ION HOMEOSTASIS NUCLEUS Transcription factor involved in sulfite metabolism; sole identified regulatory target is SSU1; overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1, contains five zinc fingers; protein abundance increases in response to DNA replication stress positive regulation of sulfite transport by positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YMR171C YMR171C EAR1 hom Verified 0.889925250603548 0.186753012228463 no 913 0.184699588674643 624 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT Specificity factor required for Rsp5p-dependent ubiquitination and sorting of specific cargo proteins at the multivesicular body; mRNA is targeted to the bud via the mRNA transport system involving She2p protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway molecular_function endosome
YDL197C YDL197C ASF2 hom Verified 0.889887584460421 0.186763125578951 no 914 0.160428278358045 536 NA FT GENE SILENCING NUCLEUS|CHROMOSOME Anti-silencing protein that causes derepression of silent loci when overexpressed chromatin silencing at silent mating-type cassette molecular_function nuclear chromosome, telomeric region|nucleus
YIL047C YIL047C SYG1 hom Verified 0.888962941934099 0.187011498173168 no 915 0.183739472809117 666 NA FT SIGNALING MITOCHONDRION|PLASMA MEMBRANE Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency signal transduction molecular_function mitochondrion|integral to membrane|plasma membrane
YJR116W_p YJR116W TDA4 hom Uncharacterized 0.888665801179431 0.18709135791912 no 916 0.131997564325445 441 NA Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele biological_process molecular_function integral to membrane
YBL052C YBL052C SAS3 hom Verified 0.888645948153545 0.187096694383155 no 917 0.190988986653482 657 NA FT CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS HISTONE ACETYLTRANSFERASE Histone acetyltransferase catalytic subunit of NuA3 complex that acetylates histone H3, involved in transcriptional silencing; homolog of the mammalian MOZ proto-oncogene; mutant has aneuploidy tolerance; sas3gcn5 double mutation is lethal histone acetylation|chromatin modification|chromatin silencing at telomere|chromatin silencing at silent mating-type cassette histone acetyltransferase activity NuA3 histone acetyltransferase complex
YML076C YML076C WAR1 hom Verified 0.888377861053712 0.18716876501896 no 918 0.161501992422328 546 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS|MITOCHONDRION Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively response to acid sequence-specific DNA binding transcription factor activity mitochondrion|nucleus
YCR099C_p YCR099C YCR099C hom Uncharacterized 0.887508029403485 0.187402722597486 no 919 0.209114056781916 726 NA Putative protein of unknown function biological_process molecular_function integral to membrane
YML009C-A_d YML009C-A YML009C-A hom Dubious 0.886407254909849 0.187699055597696 no 920 0.212337519627641 761 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YEL052W YEL052W AFG1 hom Verified 0.886057063250277 0.187793389283857 no 921 0.172564900652318 585 NA FT PROTEIN LOCALIZATION|PROTEOLYSIS|RESPONSE TO OXIDATIVE STRESS|PEROXISOME ORGANIZATION MITOCHONDRION Conserved protein that may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain protein import into peroxisome matrix|cellular response to oxidative stress|misfolded or incompletely synthesized protein catabolic process molecular_function mitochondrion|mitochondrial inner membrane
YIL128W YIL128W MET18 hom Verified 0.885774001539823 0.187869661080544 no 922 0.311549876157219 1031 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|RESPONSE TO DNA DAMAGE NUCLEUS Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Cia2p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human MMS19 methionine metabolic process|nucleotide-excision repair|transcription from RNA polymerase II promoter molecular_function cytoplasm
YDR105C YDR105C TMS1 hom Verified 0.884977007580561 0.18808451614209 no 923 0.196826546579807 668 NA Vacuolar membrane protein of unknown function that is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p, a protein involved in multidrug resistance biological_process molecular_function fungal-type vacuole membrane|integral to membrane|membrane
YBR037C YBR037C SCO1 hom Verified 0.883965667271005 0.188357373307165 no 924 0.201400262603346 681 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Copper-binding protein of mitochondrial inner membrane; required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; similar to thioredoxins; SCO1 has a paralog, SCO2, that arose from the whole genome duplication copper ion transport|response to redox state|protein complex assembly copper ion binding|thioredoxin peroxidase activity mitochondrion|mitochondrial inner membrane
YEL064C YEL064C AVT2 hom Verified 0.881258844556209 0.189088868024144 no 925 0.159563726073421 571 NA FT ENDOPLASMIC RETICULUM Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters transport transporter activity integral to membrane|endoplasmic reticulum
YMR029C YMR029C FAR8 hom Verified 0.880900914250143 0.189185726304249 no 926 0.167571510971662 558 NA FT CELL CYCLE|SIGNALING ENDOPLASMIC RETICULUM Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p re-entry into mitotic cell cycle after pheromone arrest molecular_function cellular_component
YNL176C_p YNL176C TDA7 hom Uncharacterized 0.880705926182416 0.189238504201978 no 927 0.189134718102093 592 NA Cell cycle-regulated gene of unknown function, promoter bound by Fkh2p; null mutant is sensitive to expression of the top1-T722A allele biological_process molecular_function fungal-type vacuole
YKR091W YKR091W SRL3 hom Verified 0.880629305515524 0.189259245786207 no 928 0.19444406839998 705 NA Cytoplasmic protein that, when overexpressed, suppresses the lethality of a rad53 null mutation; potential Cdc28p substrate nucleobase-containing compound metabolic process molecular_function cytoplasm
YJL154C YJL154C VPS35 hom Verified 0.880349100904031 0.189335110444377 no 929 0.230718691449539 807 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p protein retention in Golgi apparatus|retrograde transport, endosome to Golgi protein transporter activity endosome|retromer complex, inner shell|retromer complex
YIL007C YIL007C NAS2 hom Verified 0.880186622748195 0.189379109548786 no 930 0.161506556677218 578 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS NUCLEUS Proteasome-interacting protein; involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); similar to mammalian proteasomal modulator subunit; non-essential gene; interacts with Rpn4p; protein abundance increases in response to DNA replication stress proteasome regulatory particle assembly|ubiquitin-dependent protein catabolic process molecular_function cytosol|nucleus|cytoplasm
YPL134C YPL134C ODC1 hom Verified 0.88016056510338 0.189386166547722 no 931 0.178930681236512 638 NA FT MITOCHONDRION Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation mitochondrial transport dicarboxylic acid transmembrane transporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YDL174C YDL174C DLD1 hom Verified 0.880050052764751 0.189416097584633 no 932 0.161161634700742 564 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane cellular carbohydrate metabolic process|aerobic respiration D-lactate dehydrogenase (cytochrome) activity mitochondrion|mitochondrial inner membrane
YOR180C YOR180C DCI1 hom Verified 0.87903770319346 0.189690416665308 no 933 0.218065887785104 738 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS Peroxisomal protein; identification as a delta(3,5)-delta(2,4)-dienoyl-CoA isomerase involved in fatty acid metabolism is disputed fatty acid beta-oxidation dodecenoyl-CoA delta-isomerase activity peroxisomal matrix
YGR025W_d YGR025W YGR025W hom Dubious 0.87870159663867 0.189781546365808 no 934 0.157170561872885 510 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YKL073W YKL073W LHS1 hom Verified 0.878076388535653 0.189951132745391 no 935 0.215524687039793 736 NA FT PROTEIN LOCALIZATION|NUCLEOTIDE METABOLISM ENDOPLASMIC RETICULUM Molecular chaperone of the endoplasmic reticulum lumen, involved in polypeptide translocation and folding; nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; regulated by the unfolded protein response pathway posttranslational protein targeting to membrane, translocation|response to unfolded protein unfolded protein binding|adenyl-nucleotide exchange factor activity|ATP binding endoplasmic reticulum lumen
YGL218W_d YGL218W YGL218W hom Dubious 0.874492720905421 0.190924991293084 no 936 0.232687694970175 793 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 93% of ORF overlaps the verified gene MDM34; deletion in cyr1 mutant results in loss of stress resistance Unknown Unknown Unknown
YBR026C YBR026C ETR1 hom Verified 0.87425950952532 0.190988472247082 no 937 0.218669240793093 733 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION 2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family; localized to in mitochondria, where it has a probable role in fatty acid synthesis fatty acid biosynthetic process|aerobic respiration enoyl-[acyl-carrier-protein] reductase activity mitochondrion
YGL160W YGL160W AIM14 hom Verified 0.872130489855269 0.191568597232338 no 938 0.193555872115944 638 NA FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY NADPH oxidase localized to the perinuclear ER; produces superoxide from NADPH; overexpression causes MCA1 dependent apoptosis; likely involved in superoxide-mediated regulation of the actin cytoskeleton; member of a conserved superfamily of NADPH oxidases (NOX enzymes); has similarity to iron/copper reductases (FRE1-8), particularly Fre8p biological_process oxidoreductase activity, oxidizing metal ions integral to membrane|ribosome
YJL137C YJL137C GLG2 hom Verified 0.871862080295023 0.191641811237451 no 939 0.177853108793051 621 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG2 has a paralog, GLG1, that arose from the whole genome duplication glycogen biosynthetic process glycogenin glucosyltransferase activity cytoplasm
YLL063C YLL063C AYT1 hom Verified 0.870927972836669 0.191896741058387 no 940 0.15991426293262 521 NA Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis secondary metabolic process trichothecene 3-O-acetyltransferase activity cellular_component
YDR514C YDR514C YDR514C hom Verified 0.870564290387112 0.191996050748267 no 941 0.183851481400586 639 NA FT NUCLEUS|MITOCHONDRION Protein of unknown function that localizes to mitochondria; overexpression affects endocytic protein trafficking; YDR514C has a paralog, GFD2, that arose from the whole genome duplication biological_process molecular_function mitochondrion|nucleus
YLR032W YLR032W RAD5 hom Verified 0.869337321389158 0.192331327537454 no 942 0.20530391637184 739 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME DNA helicase; proposed to promote replication fork regression during postreplication repair by template switching; RING finger containing ubiquitin ligase; stimulates the synthesis of free and PCNA-bound polyubiquitin chains by Ubc13p-Mms2p; required for error-prone translesion synthesis; forms nuclear foci upon DNA replication stress double-strand break repair|postreplication repair|protein polyubiquitination|free ubiquitin chain polymerization four-way junction helicase activity|four-way junction DNA binding|DNA-dependent ATPase activity|Y-form DNA binding nuclear chromatin
YJR133W YJR133W XPT1 hom Verified 0.867100962232431 0.192943346717777 no 943 0.192266523123455 637 NA FT NUCLEOTIDE METABOLISM Xanthine-guanine phosphoribosyl transferase, required for xanthine utilization and for optimal utilization of guanine XMP salvage|hypoxanthine metabolic process xanthine phosphoribosyltransferase activity|hypoxanthine phosphoribosyltransferase activity cytoplasm
YMR320W_d YMR320W YMR320W hom Dubious 0.865522633412813 0.193375999376623 no 944 0.180490868155248 655 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLL021W YLL021W SPA2 hom Verified 0.86509271297129 0.193493951988799 no 945 0.200147275103555 700 NA FT CELL CYCLE|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate regulation of initiation of mating projection growth|regulation of termination of mating projection growth|pseudohyphal growth|invasive filamentous growth|mating projection assembly cytoskeletal regulatory protein binding incipient cellular bud site|cellular bud neck|mating projection tip|cellular bud tip
YDR216W YDR216W ADR1 hom Verified 0.864149246465543 0.193752954459832 no 946 0.207009751953125 685 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|CHROMATIN ORGANIZATION|OXIDATION-REDUCTION PROCESS|RESPONSE TO NUTRIENT LEVELS|GENE SILENCING|PEROXISOME ORGANIZATION NUCLEUS Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization negative regulation of chromatin silencing|positive regulation of transcription from RNA polymerase II promoter in response to ethanol|chromatin organization|regulation of transcription by chromatin organization|positive regulation of fatty acid beta-oxidation by positive regulation of transcription from RNA polymerase II promoter|positive regulation of peroxisome organization by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter by oleic acid|cellular response to oleic acid|peroxisome organization|positive regulation of ethanol catabolic process by positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|TFIIB-class transcription factor binding|sequence-specific DNA binding|TFIID-class transcription factor binding|RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription nucleus
YPR133W-A YPR133W-A TOM5 hom Verified 0.863366175994597 0.193968085097702 no 947 0.186939679724818 619 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import of all mitochondrially directed proteins; involved in transfer of precursors from the Tom70p and Tom20p receptors to the Tom40p pore mitochondrial outer membrane translocase complex assembly|protein targeting to mitochondrion protein channel activity mitochondrial outer membrane|mitochondrion|integral to membrane|integral to mitochondrial outer membrane|mitochondrial outer membrane translocase complex
YMR124W_p YMR124W YMR124W hom Uncharacterized 0.863271551135337 0.19399409095936 no 948 0.177849303140862 617 NA Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization biological_process molecular_function cytoplasm
YNL117W YNL117W MLS1 hom Verified 0.863229315194256 0.194005699398603 no 949 0.205155640591501 673 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM Malate synthase, enzyme of the glyoxylate cycle; involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth on oleic acid, otherwise cytosolic glyoxylate cycle malate synthase activity peroxisomal matrix|cytoplasm
YJR059W YJR059W PTK2 hom Verified 0.863022223266194 0.194062624205015 no 950 0.239379793033494 836 NA FF|FT CELL CYCLE|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS NUCLEUS|PLASMA MEMBRANE Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake protein phosphorylation|cellular ion homeostasis|polyamine transport|G1/S transition of mitotic cell cycle|regulation of cell size protein kinase activity nucleus|plasma membrane|cytoplasm
YML087C YML087C AIM33 hom Verified 0.861980765457826 0.194349051229757 no 951 0.185191859752838 609 NA FT OXIDATION-REDUCTION PROCESS Putative protein of unknown function, highly conserved across species; homolog of human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss; AIM33 has a paralog, PGA3, that arose from the whole genome duplication biological_process molecular_function cellular_component
YGL231C YGL231C EMC4 hom Verified 0.861906713047292 0.194369427297348 no 952 0.21793987233967 726 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm ZK616.6/EMC-4, fly CG11137, human TMM85 protein folding in endoplasmic reticulum molecular_function ER membrane protein complex|endoplasmic reticulum
YMR080C YMR080C NAM7 hom Verified 0.861630727487945 0.194445378217599 no 953 0.213641781666178 700 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|RNA LOCALIZATION|GENE SILENCING NUCLEUS ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance; forms cytoplasmic foci upon DNA replication stress nuclear-transcribed mRNA catabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|intracellular mRNA localization|translational frameshifting|regulation of translational termination|chromatin silencing at silent mating-type cassette|protein ubiquitination RNA-dependent ATPase activity|ATP-dependent RNA helicase activity|nucleic acid binding mitochondrion|polysome|cytoplasm
YNR008W YNR008W LRO1 hom Verified 0.859782352283567 0.194954514547944 no 954 0.197657852007819 698 NA FT LIPID METABOLISM ENDOPLASMIC RETICULUM Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase lipid storage|triglyceride biosynthetic process phospholipid:diacylglycerol acyltransferase activity lipid particle|perinuclear endoplasmic reticulum
YLR142W YLR142W PUT1 hom Verified 0.859604810537601 0.195003461187167 no 955 0.179705792387044 591 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source glutamate biosynthetic process|proline catabolic process to glutamate proline dehydrogenase activity mitochondrion
YNL155W YNL155W YNL155W hom Verified 0.859214362696438 0.195111130373564 no 956 0.174287645575893 634 NA FT NUCLEUS Protein of unknown function; contains a DHHC domain and an AN1-type zinc finger; predicted to have thiol-disulfide oxidoreductase active site; transcriptionally regulated by Rpn4p along with proteasome subunit genes; putative ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus|cytoplasm
YDL125C YDL125C HNT1 hom Verified 0.859161620485908 0.195125677239315 no 957 0.19076228028672 649 NA FT NUCLEOTIDE METABOLISM NUCLEUS Adenosine 5'-monophosphoramidase; interacts physically and genetically with Kin28p, a CDK and TFIIK subunit, and genetically with CAK1; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins and similar to Hint; protein abundance increases in response to DNA replication stress nucleotide metabolic process hydrolase activity|nucleotide binding nucleus|cytoplasm
YLR283W_p YLR283W YLR283W hom Uncharacterized 0.857018330550753 0.195717377087825 no 958 0.177625513305957 609 NA FT MITOCHONDRION Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR283W is not an essential gene biological_process molecular_function mitochondrion
YER078C YER078C ICP55 hom Verified 0.856419730739678 0.195882827412029 no 959 0.194317924888407 676 NA FT PROTEOLYSIS NUCLEUS|MITOCHONDRION Mitochondrial aminopeptidase; cleaves the N termini of at least 38 imported proteins after cleavage by the mitochondrial processing peptidase (MPP), thereby increasing their stability; member of the aminopeptidase P family protein stabilization|protein processing aminopeptidase activity extrinsic to mitochondrial inner membrane|mitochondrion|nucleus
YML117W YML117W NAB6 hom Verified 0.856242956466959 0.195931703261799 no 960 0.19240053353678 626 NA Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP biological_process molecular_function cytoplasm
YJL153C YJL153C INO1 hom Verified 0.855217757688775 0.196215303613777 no 961 0.209745432325797 701 NA FT LIPID METABOLISM|CARBOHYDRATE METABOLISM Inositol-3-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element inositol biosynthetic process inositol-3-phosphate synthase activity cytoplasm
YER057C YER057C HMF1 hom Verified 0.855025766718988 0.196268441660945 no 962 0.163598309547834 533 NA FT NUCLEUS Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro biological_process molecular_function cytosol|nucleus|cytoplasm
YLR453C YLR453C RIF2 hom Verified 0.849982819629475 0.197667319040908 no 963 0.18898928087637 704 NA FT NUCLEUS|CHROMOSOME Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation telomere capping|telomere maintenance via telomerase telomeric DNA binding nuclear telomere cap complex
YNR049C YNR049C MSO1 hom Verified 0.846245248471182 0.19870797222078 no 964 0.19683355142585 687 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Probable component of the secretory vesicle docking complex; acts at a late step in secretion; shows genetic and physical interactions with Sec1p; required for prospore membrane formation during sporulation; relocalizes from bud neck to nucleus upon DNA replication stress cellular membrane fusion|ascospore-type prospore membrane assembly|vesicle docking involved in exocytosis molecular_function SNARE complex|cellular bud membrane|plasma membrane|prospore membrane|cellular bud neck|cellular bud tip
YKL176C YKL176C LST4 hom Verified 0.845375518950895 0.198950604276618 no 965 0.225372232099427 760 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface intracellular protein transport|vesicle-mediated transport|protein transport|Golgi to plasma membrane transport protein transporter activity vesicle coat
YBR226C_d YBR226C YBR226C hom Dubious 0.844278680029497 0.199256848424393 no 966 0.24185823605864 805 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YBR225W Unknown Unknown Unknown
YDR271C_d YDR271C YDR271C hom Dubious 0.844097734975263 0.19930739665889 no 967 0.23341916090411 775 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W Unknown Unknown Unknown
YBR078W YBR078W ECM33 hom Verified 0.843750598948373 0.199404393089212 no 968 0.283707229279686 948 NA FF|FT CELL WALL ORG/BIOGENESIS MITOCHONDRION|PLASMA MEMBRANE GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p and Pst1p fungal-type cell wall organization molecular_function mitochondrion|fungal-type cell wall|plasma membrane
YER154W YER154W OXA1 hom Verified 0.842879091157322 0.199648034203253 no 969 0.218799141208364 785 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial inner membrane insertase, mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane, interacts with mitochondrial ribosomes; conserved from bacteria to animals protein insertion into mitochondrial membrane from inner side|mitochondrial genome maintenance|mitochondrial proton-transporting ATP synthase complex assembly mitochondrial ribosome binding|membrane insertase activity mitochondrion|mitochondrial inner boundary membrane|integral to membrane|mitochondrial crista|mitochondrial large ribosomal subunit
YIR002C YIR002C MPH1 hom Verified 0.840809290009114 0.200227390939234 no 970 0.202241975069226 706 NA FT RESPONSE TO DNA DAMAGE NUCLEUS 3'-5' DNA helicase involved in error-free bypass of DNA lesions; binds to flap DNA in an error-free bypass pathway and stimulates the activity of Rad27p and Dna2p; also involved in interstrand cross-link repair mutations confer a mutator phenotype; similarity to FANCM, a human Fanconi anemia complementation group protein that along with the MHF complex is involved in stabilizing and remodeling blocked replication forks; member of the SF2 DExD/H superfamily of helicases negative regulation of strand invasion|recombinational repair|DNA replication, Okazaki fragment processing flap-structured DNA binding|3'-5' DNA helicase activity nucleus
YNL202W YNL202W SPS19 hom Verified 0.838737429372381 0.200808334788443 no 971 0.22234068241542 791 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate fatty acid catabolic process|ascospore formation 2,4-dienoyl-CoA reductase (NADPH) activity peroxisomal matrix
YDR450W YDR450W RPS18A hom Verified 0.838669934356687 0.200827277197756 no 972 0.214094858774389 717 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION MITOCHONDRION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18A has a paralog, RPS18B, that arose from the whole genome duplication; protein increases in abundance and relocalizes from cytoplasm to nuclear foci upon DNA replication stress endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|cytoplasmic translation|rRNA export from nucleus structural constituent of ribosome cytosolic small ribosomal subunit|mitochondrion
YLR382C YLR382C NAM2 hom Verified 0.836795533947917 0.201353754100658 no 973 0.223460151574031 741 NA FT KETONE METABOLISM|RNA PROCESSING|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial leucyl-tRNA synthetase, also has a direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance Group I intron splicing|leucyl-tRNA aminoacylation|mitochondrial translation mRNA binding|leucine-tRNA ligase activity mitochondrion
YGL168W YGL168W HUR1 hom Verified 0.835513094808959 0.201714438576629 no 974 0.275346560111232 938 NA FF|FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene DNA replication molecular_function cellular_component
YJR113C YJR113C RSM7 hom Verified 0.833356871979697 0.202321745204785 no 975 0.225019468784884 750 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S7 ribosomal protein mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YBR141C_p YBR141C YBR141C hom Uncharacterized 0.83305448935629 0.202406999525082 no 976 0.186779897792652 598 NA FT NUCLEUS Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YBR141C is not an essential gene biological_process S-adenosylmethionine-dependent methyltransferase activity nucleolus
YOR121C_d YOR121C YOR121C hom Dubious 0.832557073602238 0.202547288574445 no 977 0.197127135492186 676 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GCY1/YOR120W Unknown Unknown Unknown
YBL048W_d YBL048W RRT1 hom Dubious 0.832507450366814 0.202561287291175 no 978 0.223666865138802 756 NA Identified in a screen for mutants with increased levels of rDNA transcription; dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data Unknown Unknown Unknown
YLR244C YLR244C MAP1 hom Verified 0.831994451928056 0.202706038062107 no 979 0.218477162299343 719 NA FT PROTEOLYSIS RIBOSOME Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p negative regulation of gene expression|protein initiator methionine removal involved in protein maturation metalloaminopeptidase activity|mRNA binding cytosolic ribosome
YPR079W YPR079W MRL1 hom Verified 0.831656375085546 0.202801465669322 no 980 0.18840491631865 627 NA FT PROTEIN LOCALIZATION|VACUOLAR TRANSPORT GOLGI APPARATUS Membrane protein; has similarity to mammalian mannose-6-phosphate receptors; possibly functions as a sorting receptor in the delivery of vacuolar hydrolases; protein abundance increases in response to DNA replication stress vacuolar transport signal sequence binding late endosome|cytoplasm
YHR079C-A YHR079C-A SAE3 hom Verified 0.831384743081458 0.202878157597954 no 981 0.210934219084448 705 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Mei5p; proposed to be an assembly factor for Dmc1p double-strand break repair|reciprocal meiotic recombination|meiotic DNA recombinase assembly molecular_function condensed nuclear chromosome
YKL119C YKL119C VPH2 hom Verified 0.830401035265979 0.203156040240415 no 982 0.210631282504372 700 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Integral membrane protein required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER) vacuolar proton-transporting V-type ATPase complex assembly|vacuolar acidification molecular_function endoplasmic reticulum membrane
YGL056C YGL056C SDS23 hom Verified 0.830200617806691 0.203212683002998 no 983 0.205140176563256 700 NA FT CELL DIVISION NUCLEUS One of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; involved in cell separation during budding; SDS23 has a paralog, SDS24, that arose from the whole genome duplication cytokinetic cell separation molecular_function nucleus|cytoplasm
YPL112C YPL112C PEX25 hom Verified 0.829517444467479 0.203405834931448 no 984 0.203279042648494 710 NA FT PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with homologous protein Pex27p protein import into peroxisome matrix|peroxisome organization molecular_function peroxisomal membrane
YMR002W YMR002W MIC17 hom Verified 0.828653055083221 0.203650378533587 no 985 0.212093195114719 719 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS|MITOCHONDRION Mitochondrial intermembrane space protein; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress aerobic respiration molecular_function nucleus|cytoplasm|mitochondrial intermembrane space
YAR029W_p YAR029W YAR029W hom Uncharacterized 0.827890517284457 0.203866252870038 no 986 0.194187939053633 683 NA Member of DUP240 gene family but contains no transmembrane domains; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern biological_process molecular_function cytoplasm
YJR148W YJR148W BAT2 hom Verified 0.826169273345957 0.204354037868759 no 987 0.189457101245716 651 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Cytosolic branched-chain amino acid (BCAA) aminotransferase, preferentially involved in BCAA catabolism; homolog of murine ECA39; highly expressed during stationary phase and repressed during logarithmic phase branched-chain amino acid catabolic process|branched-chain amino acid biosynthetic process branched-chain-amino-acid transaminase activity nucleus|cytoplasm
YLR121C YLR121C YPS3 hom Verified 0.825589782107654 0.204518416666772 no 988 0.208337083183411 725 NA FT CELL WALL ORG/BIOGENESIS|PROTEOLYSIS PLASMA MEMBRANE Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor fungal-type cell wall organization|cellular protein metabolic process aspartic-type endopeptidase activity anchored to plasma membrane|plasma membrane
YPL254W YPL254W HFI1 hom Verified 0.825580751249107 0.204520978987521 no 989 0.222411612151493 768 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS HISTONE ACETYLTRANSFERASE Adaptor protein required for structural integrity of the SAGA complex, a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions histone acetylation|chromatin modification|transcription from RNA polymerase II promoter transcription coactivator activity|transcription cofactor activity SLIK (SAGA-like) complex|Ada2/Gcn5/Ada3 transcription activator complex|SAGA complex
YKL220C YKL220C FRE2 hom Verified 0.824471088060019 0.204835968511596 no 990 0.174977128568013 578 NA FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY PLASMA MEMBRANE Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels iron ion transport|copper ion import ferric-chelate reductase activity integral to membrane|plasma membrane
YMR107W YMR107W SPG4 hom Verified 0.821720126570161 0.20561810083515 no 991 0.179587852866843 649 NA Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources biological_process molecular_function cellular_component
YDL099W YDL099W BUG1 hom Verified 0.82108039612001 0.205800237840873 no 992 0.170518586137173 606 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT GOLGI APPARATUS Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes protein secretion|ER to Golgi vesicle-mediated transport molecular_function cis-Golgi network|cytoplasm
YLR154C YLR154C RNH203 hom Verified 0.820105237922871 0.206078058245802 no 993 0.185856108099229 614 NA FT NUCLEUS Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS3 that causes Aicardi-Goutieres syndrome RNA catabolic process|DNA replication, removal of RNA primer ribonuclease H activity ribonuclease H2 complex|nucleus|cytoplasm
YOR079C YOR079C ATX2 hom Verified 0.818553384137382 0.206520636219106 no 994 0.165587413078353 551 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Golgi membrane protein involved in manganese homeostasis; overproduction suppresses the sod1 (copper, zinc superoxide dismutase) null mutation cellular manganese ion homeostasis manganese ion transmembrane transporter activity integral to membrane|Golgi membrane
YKR096W YKR096W ESL2 hom Verified 0.81853772199765 0.206525105821137 no 995 0.213501049503697 714 NA FT NUCLEUS Protein of unknown function that interacts with Pex14p; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; predicted to contain a PINc domain biological_process molecular_function ribosome|nucleus|cytoplasm
YHR111W YHR111W UBA4 hom Verified 0.818176993995848 0.206628064867294 no 996 0.213502903073029 735 NA FT RNA PROCESSING|CELL DIVISION|RESPONSE TO OXIDATIVE STRESS Protein that activates Urm1p before its conjugation to proteins (urmylation); also acts in thiolation of the wobble base of cytoplasmic tRNAs by adenylating and then thiolating Urm1p; receives sulfur from Tum1p cellular response to oxidative stress|tRNA wobble position uridine thiolation|cell budding|protein urmylation|tRNA thio-modification|Unknown|invasive growth in response to glucose limitation URM1 activating enzyme activity|sulfurtransferase activity|thiosulfate sulfurtransferase activity|protein adenylyltransferase activity cytoplasm
YCR007C_p YCR007C YCR007C hom Uncharacterized 0.81798238693699 0.206683622267213 no 997 0.222115560603734 731 NA Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene biological_process molecular_function cellular_component
YKR056W YKR056W TRM2 hom Verified 0.817943635151871 0.206694686377312 no 998 0.198693526730051 719 NA FT RNA PROCESSING|RESPONSE TO DNA DAMAGE tRNA methyltransferase, 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation; endo-exonuclease with a role in DNA repair double-strand break repair|DNA repair|tRNA modification tRNA (m5U54) methyltransferase activity|double-stranded DNA specific 5'-3' exodeoxyribonuclease activity|single-stranded DNA specific endodeoxyribonuclease activity cellular_component
YGR249W YGR249W MGA1 hom Verified 0.815888401563151 0.207281983173096 no 999 0.211189073675363 724 NA FT NUCLEUS Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants filamentous growth sequence-specific DNA binding|DNA binding|sequence-specific DNA binding transcription factor activity nucleus
YHL012W_p YHL012W YHL012W hom Uncharacterized 0.815801203180187 0.207306922498289 no 1000 0.174684272398988 603 NA Putative UTP glucose-1-phosphate uridylyltransferase; YHL012W has a paralog, UGP1, that arose from the whole genome duplication biological_process molecular_function cellular_component
YDR369C YDR369C XRS2 hom Verified 0.814885923961141 0.207568805558203 no 1001 0.220973197068409 767 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling double-strand break repair via nonhomologous end joining|meiotic DNA double-strand break formation|base-excision repair|telomere maintenance|sporulation resulting in formation of a cellular spore|double-strand break repair via break-induced replication single-stranded telomeric DNA binding|protein binding, bridging|DNA binding|double-stranded telomeric DNA binding|telomeric DNA binding|G-quadruplex DNA binding nucleus|Mre11 complex
YOR343C_d YOR343C YOR343C hom Dubious 0.814793190730489 0.207595349634243 no 1002 0.186096177845444 666 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YMR204C YMR204C INP1 hom Verified 0.814762247872558 0.207604207202925 no 1003 0.193747481657492 631 NA FT PEROXISOME ORGANIZATION Peripheral membrane protein of peroxisomes involved in peroxisomal inheritance; recruitment to peroxisomes is mediated by interaction with Pex3p at the peroxisomal membrane peroxisome inheritance molecular_function peroxisome|extrinsic to intraperoxisomal membrane
YEL040W YEL040W UTR2 hom Verified 0.814316691703411 0.207731774941976 no 1004 0.199392885453194 641 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM SITE OF POLARIZED GROWTH|CYTOSKELETON Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck cell wall chitin metabolic process|fungal-type cell wall organization transferase activity, transferring glycosyl groups cellular bud neck septin ring|fungal-type cell wall
YLR445W YLR445W GMC2 hom Verified 0.81333866776693 0.208011956510451 no 1005 0.208758430350869 720 NA FT CELL CYCLE Protein involved in meiotic progression; mutants are delayed in meiotic nuclear division and are defective in synaptonemal complex assembly; transcription is regulated by Ume6p and induced in response to alpha factor meiosis|synaptonemal complex organization molecular_function cellular_component
YBL051C YBL051C PIN4 hom Verified 0.812232912609207 0.208328998701665 no 1006 0.228134288912428 798 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage G2/M transition of mitotic cell cycle|DNA damage checkpoint molecular_function cytoplasm
YPL236C YPL236C ENV7 hom Verified 0.811901650298054 0.208424033713828 no 1007 0.181517143542665 671 NA FT PROTEIN PHOSPHORYLATION|VACUOLAR PROTEIN PROCESSING Vacuolar membrane protein kinase; negatively regulates membrane fusion; associates with vacuolar membrane through palmitoylation of one or more cysteines in consensus sequence; vacuolar membrane association is essential to its kinase activity; mutant shows defect in CPY processing; ortholog of human serine/threonine kinase 16 (STK16) vacuolar protein processing protein serine/threonine kinase activity fungal-type vacuole membrane
YGL028C YGL028C SCW11 hom Verified 0.811772233253727 0.208461168789099 no 1008 0.220146691889148 758 NA FT CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p cytokinesis, completion of separation glucan endo-1,3-beta-D-glucosidase activity fungal-type cell wall
YJL045W YJL045W YJL045W hom Verified 0.811312521295076 0.208593110608755 no 1009 0.200897959088452 684 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner cellular respiration succinate dehydrogenase (ubiquinone) activity mitochondrion
YNL315C YNL315C ATP11 hom Verified 0.811021128275129 0.208676768737362 no 1010 0.211870027334346 749 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase mitochondrion organization|mitochondrial proton-transporting ATP synthase complex assembly unfolded protein binding mitochondrion|mitochondrial matrix
YLL049W YLL049W LDB18 hom Verified 0.810561075846266 0.208808888765958 no 1011 0.188468432808078 652 NA FT CELL CYCLE|CYTOSKELETON ORGANIZATION CYTOSKELETON Component of the dynactin complex, which is required for dynein activity; null mutant exhibits defects in nuclear migration and spindle orientation and has reduced affinity for alcian blue dye; has homology to mammalian dynactin subunit p24 establishment of mitotic spindle orientation molecular_function dynactin complex|cell cortex|spindle pole body|astral microtubule
YGR026W_p YGR026W YGR026W hom Uncharacterized 0.809861455756555 0.209009903411923 no 1012 0.2164552365695 706 NA FT PLASMA MEMBRANE Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery biological_process molecular_function integral to membrane
YPL158C YPL158C AIM44 hom Verified 0.808842995343908 0.209302730797007 no 1013 0.253078066000086 863 NA FT SITE OF POLARIZED GROWTH Protein of unknown function; GFP-fusion protein localizes to the bud neck; transcription is regulated by Swi5p; null mutant displays elevated frequency of mitochondrial genome loss; relocalizes from bud neck to cytoplasm upon DNA replication stress biological_process molecular_function cellular bud neck
YJR151W-A_p YJR151W-A YJR151W-A hom Uncharacterized 0.808777506261254 0.20932156845418 no 1014 0.202648077444906 675 NA Putative protein of unknown function; identified by fungal homology and RT-PCR; predicted to have a role in transcription based on computational guilt by association analysis biological_process molecular_function cellular_component
YNL237W YNL237W YTP1 hom Verified 0.807831400463561 0.209593823095286 no 1015 0.274546245310491 966 NA FF|FT MITOCHONDRION Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins biological_process molecular_function integral to membrane|membrane
YGL135W YGL135W RPL1B hom Verified 0.807561669422255 0.209671479959001 no 1016 0.230828331229799 799 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L1B; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1B has a paralog, RPL1A, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YLR352W_p YLR352W YLR352W hom Uncharacterized 0.806614826753119 0.209944214426949 no 1017 0.203765802742283 688 NA Putative protein of unknown function with similarity to F-box proteins; interacts with Skp1p and Cdc53p; YLR352W is not an essential gene biological_process molecular_function SCF ubiquitin ligase complex
YKR018C YKR018C YKR018C hom Verified 0.806612886841493 0.209944773425123 no 1018 0.205053987037311 710 NA FT NUCLEUS|MITOCHONDRION Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress; YKR018C has a paralog, IML2, that arose from the whole genome duplication biological_process molecular_function nucleus|cytoplasm
YDR521W_d YDR521W YDR521W hom Dubious 0.804791485264091 0.210470008011069 no 1019 0.184034986107951 561 NA Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol Unknown Unknown Unknown
YKL188C YKL188C PXA2 hom Verified 0.80335805787528 0.210883904927361 no 1020 0.197468433053055 660 NA FT NUCLEOTIDE METABOLISM Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter ABCD1 and ABCD2 and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder fatty acid transport ATPase activity, coupled to transmembrane movement of substances integral to membrane|integral to peroxisomal membrane
YNL292W YNL292W PUS4 hom Verified 0.802539858191484 0.211120370910083 no 1021 0.215315359650039 751 NA FT RNA PROCESSING NUCLEUS|MITOCHONDRION Pseudouridine synthase, catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs; PUS4 overexpression leads to translational derepression of GCN4 (Gcd- phenotype) tRNA modification pseudouridine synthase activity mitochondrion|nucleus
YDL240W YDL240W LRG1 hom Verified 0.80199758800527 0.211277176739742 no 1022 0.215355339893756 720 NA FT SIGNALING|CELL WALL ORG/BIOGENESIS MITOCHONDRION|SITE OF POLARIZED GROWTH Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity; appears to specifically regulate 1,3-beta-glucan synthesis fungal-type cell wall biogenesis|small GTPase mediated signal transduction Rho GTPase activator activity mitochondrion|cellular bud neck|cytoplasm
YGL109W_d YGL109W YGL109W hom Dubious 0.801561626080688 0.211403291350844 no 1023 0.17575919287882 592 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized gene YGL108C Unknown Unknown Unknown
YHR194W YHR194W MDM31 hom Verified 0.800708567315247 0.211650190801686 no 1024 0.237973608108837 801 NA FT ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS NUCLEUS|MITOCHONDRION Mitochondrial protein that may have a role in phospholipid metabolism; inner membrane protein with similarity to Mdm32p; required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MMM2, MDM10, MDM12, and MDM34 mitochondrion inheritance|cellular ion homeostasis|mitochondrion organization|Unknown molecular_function mitochondrial inner membrane|nucleus
YDR155C YDR155C CPR1 hom Verified 0.799318008077395 0.212053019772629 no 1025 0.209043732840903 758 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CHROMATIN ORGANIZATION NUCLEUS|MITOCHONDRION|CHROMOSOME Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A; protein abundance increases in response to DNA replication stress cellular protein metabolic process|ascospore formation|positive regulation of meiosis|histone deacetylation peptidyl-prolyl cis-trans isomerase activity|cyclosporin A binding histone deacetylase complex|mitochondrion|Set3 complex|nucleus
YCR008W YCR008W SAT4 hom Verified 0.798599417144726 0.212261362864997 no 1026 0.208220171865471 727 NA FT PROTEIN LOCALIZATION|CELL CYCLE|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; partially redundant with Hal5p; has similarity to Npr1p cellular cation homeostasis|protein phosphorylation|cellular protein localization|G1/S transition of mitotic cell cycle|protein dephosphorylation protein kinase activity cellular_component
YLR285C-A_p YLR285C-A YLR285C-A hom Uncharacterized 0.798359797859232 0.21233086295013 no 1027 0.198151719331796 652 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YPL119C-A_p YPL119C-A YPL119C-A hom Uncharacterized 0.797714497448601 0.212518094442293 no 1028 0.209400872594681 690 NA Putative protein of unknown function; identified by expression profiling and mass spectrometry biological_process molecular_function cellular_component
YHR021C YHR021C RPS27B hom Verified 0.797381034687224 0.212614885193526 no 1029 0.228270985930075 763 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27B has a paralog, RPS27A, that arose from the whole genome duplication cytoplasmic translation|ribosomal small subunit assembly|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit
YOR342C YOR342C YOR342C hom Verified 0.796868811767494 0.212763612922433 no 1030 0.223733872485327 776 NA FT NUCLEUS Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; relocalizes from nucleus to cytoplasm upon DNA replication stress; YOR342C has a paralog, YAL037W, that arose from the whole genome duplication biological_process molecular_function nucleus|cytoplasm
YGL220W YGL220W FRA2 hom Verified 0.796822237941397 0.212777138990387 no 1031 0.21257129882652 712 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; null mutant fails to repress iron regulon and is sensitive to nickel negative regulation of transcription from RNA polymerase II promoter in response to iron molecular_function cytosol|nucleus|cytoplasm
YIR020C_p YIR020C YIR020C hom Uncharacterized 0.795977269452412 0.213022623661933 no 1032 0.179646108896648 628 NA Protein of unknown function; mRNA identified as translated by ribosome profiling data biological_process molecular_function cellular_component
YPL248C YPL248C GAL4 hom Verified 0.794833428818648 0.21335520134568 no 1033 0.198347894088373 705 NA FT TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS NUCLEUS DNA-binding transcription factor required for the activation of the GAL genes in response to galactose; repressed by Gal80p and activated by Gal3p galactose metabolic process|positive regulation of transcription from RNA polymerase II promoter by galactose RNA polymerase II transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity nucleus
YLR182W YLR182W SWI6 hom Verified 0.794166915392339 0.213549133132354 no 1034 0.251075216414894 872 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE NUCLEUS Transcription cofactor; forms complexes with Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; also binds Stb1p to regulate transcription at START; cell wall stress induces phosphorylation by Mpk1p, which regulates Swi6p localization; required for the unfolded protein response, independently of its known transcriptional coactivators positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription involved in G1/S phase of mitotic cell cycle|positive regulation of reciprocal meiotic recombination|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription coactivator activity SBF transcription complex|MBF transcription complex|nucleus|cytoplasm
YFL041W YFL041W FET5 hom Verified 0.793859820255128 0.213638521489817 no 1035 0.187120097307763 654 NA FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS PLASMA MEMBRANE Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport iron ion transport ferroxidase activity fungal-type vacuole membrane|integral to membrane
YDR142C YDR142C PEX7 hom Verified 0.79274245116983 0.213963945920715 no 1036 0.236352411591863 766 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PEROXISOME ORGANIZATION Peroxisomal signal receptor for the N-terminal nonapeptide signal (PTS2) of peroxisomal matrix proteins; WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodysplasia punctata (RCDP) protein import into peroxisome matrix, docking peroxisome matrix targeting signal-2 binding cytosol|peroxisome
YPR071W_p YPR071W YPR071W hom Uncharacterized 0.79272267040795 0.213969709500969 no 1037 0.224872822270576 767 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Putative membrane protein; YPR071W is not an essential gene; YPR071W has paralog YIL029C biological_process molecular_function integral to membrane
YDR293C YDR293C SSD1 hom Verified 0.791884086485957 0.214214133347985 no 1038 0.338660317540283 1177 NA FF|FT CELL CYCLE|TRANSLATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION|RNA LOCALIZATION NUCLEUS|SITE OF POLARIZED GROWTH Translational repressor with a role in polar growth and wall integrity; regulated by Cbk1p phosphorylation to effect bud-specific translational control and localization of specific mRNAs; interacts with TOR pathway components; contains a functional N-terminal nuclear localization sequence and nucleocytoplasmic shuttling appears to be critical to Ssd1p function regulation of fungal-type cell wall organization|negative regulation of translation|intracellular mRNA localization mRNA binding|mRNA 5'-UTR binding|translation repressor activity, nucleic acid binding nucleus|cellular bud|cytoplasmic stress granule|cytoplasmic mRNA processing body|cellular bud neck|cytoplasm
YOL164W YOL164W BDS1 hom Verified 0.791568069946564 0.214306285489735 no 1039 0.233490918828584 790 NA Bacterially-derived sulfatase required for use of alkyl- and aryl-sulfates as sulfur sources dodecyl sulfate metabolic process arylsulfatase activity|alkyl sulfatase activity cellular_component
YOL060C YOL060C MAM3 hom Verified 0.791367329482205 0.214364834474949 no 1040 0.200852415772203 709 NA FT ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS Protein required for normal mitochondrial morphology, has similarity to hemolysins cellular manganese ion homeostasis|mitochondrion organization molecular_function fungal-type vacuole membrane|integral to membrane
YEL033W_p YEL033W MTC7 hom Uncharacterized 0.790990851081696 0.214474665161254 no 1041 0.260605193381581 888 NA Predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant biological_process molecular_function cellular_component
YHL020C YHL020C OPI1 hom Verified 0.789992690420294 0.214766018594701 no 1042 0.231489259630721 832 NA FT TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM|SIGNALING ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Transcriptional regulator of a variety of genes; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; involved in telomere maintenance endoplasmic reticulum unfolded protein response|negative regulation of transcription from RNA polymerase II promoter|phospholipid biosynthetic process|positive regulation of transcription from RNA polymerase II promoter transcription corepressor activity nuclear membrane|nucleoplasm|nuclear envelope|endoplasmic reticulum|nucleus
YOR036W YOR036W PEP12 hom Verified 0.789597097742576 0.2148815518678 no 1043 0.25541238249591 910 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT GOLGI APPARATUS Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin Golgi to vacuole transport|vacuole inheritance SNAP receptor activity endosome|Golgi apparatus
YER076C_p YER076C YER076C hom Uncharacterized 0.789109234014823 0.215024082704367 no 1044 0.210483287427371 691 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; analysis of HA-tagged protein suggests a membrane localization biological_process molecular_function mitochondrion
YCL075W YCL075W YCL075W hom pseudogene 0.78908747034239 0.215030442304733 no 1045 0.192438241345936 665 NA FT NUCLEUS Pseudogene: encodes fragment of Ty Pol protein transposition, RNA-mediated ribonuclease activity|peptidase activity|RNA binding|RNA-directed DNA polymerase activity|DNA-directed DNA polymerase activity retrotransposon nucleocapsid
YHR109W YHR109W CTM1 hom Verified 0.784953654378533 0.216240371032968 no 1046 0.1897774626557 648 NA Cytochrome c lysine methyltransferase, trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol; not required for normal respiratory growth peptidyl-lysine methylation [cytochrome c]-lysine N-methyltransferase activity cytosol
YBR207W YBR207W FTH1 hom Verified 0.782800037296203 0.216872272837169 no 1047 0.16426515314018 584 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress endocytosis|high-affinity iron ion transport iron ion transmembrane transporter activity fungal-type vacuole membrane|integral to membrane
YJR063W YJR063W RPA12 hom Verified 0.782731161115289 0.216892499686328 no 1048 0.249117635084323 886 NA FF|FT NUCLEUS RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex termination of RNA polymerase I transcription|transcription of nuclear large rRNA transcript from RNA polymerase I promoter molecular_function DNA-directed RNA polymerase I complex
YBL086C_p YBL086C YBL086C hom Uncharacterized 0.782135357458627 0.217067514695353 no 1049 0.196893211218168 647 NA Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery biological_process molecular_function cellular_component
YAL056W YAL056W GPB2 hom Verified 0.781994577569834 0.217108880156384 no 1050 0.21123244231558 707 NA FT TRANSCRIPTION FROM RNA POL II|SIGNALING MITOCHONDRION|PLASMA MEMBRANE Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; GPB2 has a paralog, GPB1, that arose from the whole genome duplication signal transduction|glucose mediated signaling pathway|pseudohyphal growth|ascospore formation|negative regulation of Ras protein signal transduction|invasive growth in response to glucose limitation|positive regulation of transcription from RNA polymerase II promoter cAMP-dependent protein kinase inhibitor activity|signal transducer activity|GTPase activating protein binding mitochondrion|plasma membrane|cytoplasm
YER158C_p YER158C YER158C hom Uncharacterized 0.7819514050645 0.217121566478688 no 1051 0.1815209577215 635 NA Protein of unknown function; potentially phosphorylated by Cdc28p; YER158C has a paralog, AFR1, that arose from the whole genome duplication biological_process molecular_function cellular_component
YIR001C YIR001C SGN1 hom Verified 0.7818229843115 0.217159305691436 no 1052 0.21586300343342 744 NA Cytoplasmic RNA-binding protein, contains an RNA recognition motif (RRM); may have a role in mRNA translation, as suggested by genetic interactions with genes encoding proteins involved in translational initiation mRNA metabolic process poly(A) RNA binding cytoplasm
YDR182W-A_p YDR182W-A YDR182W-A hom Uncharacterized 0.781414604899583 0.217279341987892 no 1053 0.227249194936726 747 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YLR171W_d YLR171W YLR171W hom Dubious 0.780721784242624 0.217483072656605 no 1054 0.228855464110569 806 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YMR319C YMR319C FET4 hom Verified 0.779929256303347 0.217716258385908 no 1055 0.279696383334591 948 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Low-affinity Fe(II) transporter of the plasma membrane intracellular copper ion transport|zinc ion transport|low-affinity iron ion transport|copper ion import copper ion transmembrane transporter activity|iron ion transmembrane transporter activity integral to membrane|plasma membrane|integral to plasma membrane
YOR347C YOR347C PYK2 hom Verified 0.77746286894787 0.218442866537033 no 1056 0.188011468144541 650 NA FT KETONE METABOLISM|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Pyruvate kinase; appears to be modulated by phosphorylation; transcription repressed by glucose, and Pyk2p may be active under low glycolytic flux; PYK2 has a paralog, CDC19, that arose from the whole genome duplication pyruvate metabolic process pyruvate kinase activity cytosol|mitochondrion
YGR135W YGR135W PRE9 hom Verified 0.777072718013149 0.218557934453182 no 1057 0.221811941665912 740 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION Alpha 3 subunit of the 20S proteasome, the only nonessential 20S subunit; may be replaced by the alpha 4 subunit (Pre6p) under stress conditions to create a more active proteasomal isoform proteasomal ubiquitin-dependent protein catabolic process|proteasome core complex assembly|proteasomal ubiquitin-independent protein catabolic process molecular_function mitochondrion|proteasome core complex, alpha-subunit complex|proteasome storage granule|nucleus|nuclear outer membrane-endoplasmic reticulum membrane network
YHR014W YHR014W SPO13 hom Verified 0.77611234198711 0.218841328515169 no 1058 0.184941036465831 620 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Meiosis-specific protein, involved in maintaining sister chromatid cohesion during meiosis I as well as promoting proper attachment of kinetochores to the spindle during meiosis I and meiosis II protein localization to chromosome, centromeric region|meiotic sister chromatid cohesion|positive regulation of sister chromatid cohesion molecular_function nucleus|condensed nuclear chromosome, centromeric region
YMR210W YMR210W YMR210W hom Verified 0.775952219179131 0.218888599160031 no 1059 0.184229915789835 579 NA FT KETONE METABOLISM|LIPID METABOLISM Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification medium-chain fatty acid biosynthetic process transferase activity, transferring acyl groups cellular_component
YOR178C YOR178C GAC1 hom Verified 0.775161490536415 0.219122120179403 no 1060 0.222154459956092 745 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock meiosis|glycogen metabolic process|negative regulation of transcription from RNA polymerase II promoter|response to heat|mitotic cell cycle spindle assembly checkpoint protein phosphatase type 1 regulator activity|structural molecule activity|heat shock protein binding protein phosphatase type 1 complex
YLR122C_d YLR122C YLR122C hom Dubious 0.774884890676275 0.219203840517412 no 1061 0.225485868192627 724 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C Unknown Unknown Unknown
YJR078W YJR078W BNA2 hom Verified 0.774726917247108 0.219250521003522 no 1062 0.19406525350008 651 NA FT OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for de novo biosynthesis of NAD from tryptophan via kynurenine; interacts genetically with telomere capping gene CDC13; regulated by Hst1p and Aftp de novo NAD biosynthetic process from tryptophan tryptophan 2,3-dioxygenase activity|indoleamine 2,3-dioxygenase activity cytoplasm
YAL008W YAL008W FUN14 hom Verified 0.774563828170455 0.219298719135935 no 1063 0.238558978523492 769 NA FT MITOCHONDRION Mitochondrial protein of unknown function biological_process molecular_function mitochondrial outer membrane|mitochondrion
YNL299W YNL299W TRF5 hom Verified 0.774337266738331 0.21936568552062 no 1064 0.232414592293185 821 NA FT CELL CYCLE|RNA PROCESSING|CELL DIVISION NUCLEUS Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Pap2p nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent snRNA catabolic process|ncRNA polyadenylation|histone mRNA catabolic process|nuclear polyadenylation-dependent mRNA catabolic process|U4 snRNA 3'-end processing|polyadenylation-dependent snoRNA 3'-end processing|snoRNA polyadenylation polynucleotide adenylyltransferase activity nucleolus|TRAMP complex
YDL039C YDL039C PRM7 hom Verified 0.773510604798037 0.219610127544411 no 1065 0.214016343925611 682 NA Pheromone-regulated protein, predicted to have one transmembrane segment; promoter contains Gcn4p binding elements conjugation with cellular fusion molecular_function integral to membrane
YGL034C_d YGL034C YGL034C hom Dubious 0.77323431725737 0.219691859995503 no 1066 0.236843971985665 784 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YKL185W YKL185W ASH1 hom Verified 0.772440493505132 0.219926789171677 no 1067 0.177992536355951 633 NA FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate Unknown RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|core promoter proximal region sequence-specific DNA binding Rpd3L-Expanded complex|nucleus|cellular bud|Rpd3L complex
YDL057W_p YDL057W YDL057W hom Uncharacterized 0.772426442211069 0.21993094889778 no 1068 0.190719641030987 642 NA Putative protein of unknown function; YDL057W is not an essential gene biological_process molecular_function cellular_component
YGL079W_p YGL079W KXD1 hom Uncharacterized 0.772267818715501 0.219977910714588 no 1069 0.206214677042185 680 NA Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; GFP-fusion protein localizes to the endosome biological_process molecular_function endosome
YGL039W YGL039W YGL039W hom Verified 0.771971300072387 0.220065712975591 no 1070 0.192424018704485 646 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS Oxidoreductase shown to reduce carbonyl compounds to chiral alcohols cellular ketone metabolic process|cellular aromatic compound metabolic process oxidoreductase activity, acting on CH-OH group of donors|carbonyl reductase (NADPH) activity cytoplasm
YBL103C YBL103C RTG3 hom Verified 0.771874622955763 0.220094344422867 no 1071 0.21205288946889 705 NA FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|SIGNALING NUCLEUS Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways mitochondrion degradation|cellular response to oleic acid|mitochondria-nucleus signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription factor import into nucleus RNA polymerase II transcription factor binding|sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity nucleus|cytoplasm
YGL221C YGL221C NIF3 hom Verified 0.770134721120049 0.22060999083761 no 1072 0.212272274490104 703 NA FT MITOCHONDRION Protein of unknown function, similar to Listeria monocytogenes major sigma factor (rpoD gene product); the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion|cytoplasm
YDR323C YDR323C PEP7 hom Verified 0.769800340624927 0.220709168817936 no 1073 0.282186209777417 959 NA FF|FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance Golgi to vacuole transport|vacuole inheritance|vesicle fusion|vesicle docking involved in exocytosis|Golgi to endosome transport phosphatidylinositol-3-phosphate binding external side of endosome membrane|cytoplasm
YPL092W YPL092W SSU1 hom Verified 0.768990591040482 0.220949448072854 no 1074 0.224648426303277 710 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein sulfite transport sulfite transmembrane transporter activity integral to membrane|plasma membrane
YBR249C YBR249C ARO4 hom Verified 0.767529057063829 0.221383511940511 no 1075 0.217453637194678 753 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan; relative distribution to the nucleus increases upon DNA replication stress aromatic amino acid family biosynthetic process 3-deoxy-7-phosphoheptulonate synthase activity nucleus|cytoplasm
YIL140W YIL140W AXL2 hom Verified 0.76672827746634 0.221621543676613 no 1076 0.217568941853882 734 NA FT CELL CYCLE|CELL DIVISION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON Integral plasma membrane protein required for axial budding in haploid cells, localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate axial cellular bud site selection|cellular bud site selection molecular_function integral to plasma membrane|cellular bud neck|septin ring
YGR085C YGR085C RPL11B hom Verified 0.765679052690724 0.221933646994852 no 1077 0.249999679274407 844 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal 60S subunit protein L11B; expressed at half the level of Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of 60S proteins and RNA; homologous to mammalian ribosomal protein L11 and bacterial L5; RPL11B has a paralog, RPL11A, that arose from the whole genome duplication cytoplasmic translation|ribosomal large subunit assembly structural constituent of ribosome cytosolic large ribosomal subunit
YOL128C YOL128C YGK3 hom Verified 0.765005730607458 0.222134066112941 no 1078 0.218229013198472 711 NA FT PROTEOLYSIS|PROTEIN PHOSPHORYLATION Protein kinase related to mammalian glycogen synthase kinases of the GSK-3 family; GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradation proteolysis|protein phosphorylation|response to stress protein serine/threonine kinase activity|protein kinase activity cellular_component
YPL203W YPL203W TPK2 hom Verified 0.764791577355552 0.222197832001144 no 1079 0.218815391184699 756 NA FT SIGNALING|PROTEIN PHOSPHORYLATION NUCLEUS cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk3p; localizes to P-bodies during stationary phase protein phosphorylation|Ras protein signal transduction|invasive growth in response to glucose limitation cAMP-dependent protein kinase activity|protein kinase activity nucleus|cAMP-dependent protein kinase complex
YDL130W-A YDL130W-A STF1 hom Verified 0.76326763614734 0.222651899546246 no 1080 0.238587820139705 852 NA FT NUCLEOTIDE METABOLISM MITOCHONDRION Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p act as stabilizing factors that enhance inhibitory action of the Inh1p protein; protein abundance increases in response to DNA replication stress negative regulation of ATPase activity molecular_function mitochondrion|mitochondrial proton-transporting ATP synthase complex
YCL051W YCL051W LRE1 hom Verified 0.762950718759874 0.222746393399669 no 1081 0.237828947169291 818 NA FT CELL WALL ORG/BIOGENESIS Protein involved in control of cell wall structure and stress response; overproduction confers resistance to cell-wall degrading enzymes; exhibits genetic interactions with genes involved in the cell wall integrity pathway;
LRE1 has a paralog, HLR1, that arose from the whole genome duplication fungal-type cell wall organization molecular_function cellular_component
YDL025C YDL025C RTK1 hom Verified 0.76244816459313 0.222896284595814 no 1082 0.26589524557465 902 NA FT PROTEIN PHOSPHORYLATION Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance increases in response to DNA replication stress biological_process protein serine/threonine kinase activity|protein kinase activity cellular_component
YOR228C YOR228C YOR228C hom Verified 0.762029720120826 0.223021133165397 no 1083 0.228632980925952 779 NA FT MITOCHONDRION Protein of unknown function, localized to the mitochondrial outer membrane biological_process molecular_function mitochondrial outer membrane|mitochondrion|integral to membrane
YOL067C YOL067C RTG1 hom Verified 0.76144344220466 0.223196124085607 no 1084 0.250681501991114 842 NA FT TRANSCRIPTION FROM RNA POL II|SIGNALING NUCLEUS Transcription factor (bHLH) involved in interorganelle communication between mitochondria, peroxisomes, and nucleus cellular response to oleic acid|positive regulation of transcription from RNA polymerase II promoter|mitochondria-nucleus signaling pathway sequence-specific DNA binding RNA polymerase II transcription factor activity nucleus|cytoplasm
YOR114W_p YOR114W YOR114W hom Uncharacterized 0.760592342123644 0.223450297575179 no 1085 0.229156086110587 775 NA Putative protein of unknown function; null mutant is viable biological_process molecular_function cellular_component
YBR220C_p YBR220C YBR220C hom Uncharacterized 0.760298603635638 0.223538058177708 no 1086 0.22181456829997 761 NA Putative protein of unknown function; YBR220C is not an essential gene biological_process molecular_function integral to membrane
YGL149W_d YGL149W YGL149W hom Dubious 0.760260438910725 0.223549462137542 no 1087 0.213136236728074 714 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF INO80/YGL150C. Unknown Unknown Unknown
YBL107C YBL107C MIC23 hom Verified 0.759991743020733 0.2236297602286 no 1088 0.230471708313436 769 NA Mitochondrial intermembrane space protein of unknown function; imported via the MIA import machinery; contains an unusual twin cysteine motif (CX13C CX14C) biological_process molecular_function cytoplasm
YJL048C YJL048C UBX6 hom Verified 0.759963677757925 0.223638148303306 no 1089 0.210367362623069 715 NA FT PROTEOLYSIS NUCLEUS UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p, transcription is repressed when cells are grown in media containing inositol and choline; UBX6 has a paralog, UBX7, that arose from the whole genome duplication sporulation resulting in formation of a cellular spore|ubiquitin-dependent protein catabolic process molecular_function nucleus
YGL261C_p YGL261C PAU11 hom Uncharacterized 0.759634369385685 0.223736584520789 no 1090 0.222868152439314 748 NA Putative protein of unknown function and member of the seripauperin multigene family encoded mainly in subtelomeric regions; mRNA expression appears to be regulated by SUT1 and UPC2 biological_process molecular_function cellular_component
YOL024W_p YOL024W YOL024W hom Uncharacterized 0.759240054339147 0.223854484805802 no 1091 0.213085198519336 714 NA Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site; YOL024W has a paralog, IGD1, that arose from the whole genome duplication biological_process molecular_function cellular_component
YML024W YML024W RPS17A hom Verified 0.759055616786459 0.223909643792716 no 1092 0.210305645149048 704 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17A has a paralog, RPS17B, that arose from the whole genome duplication cytoplasmic translation|ribosomal small subunit assembly structural constituent of ribosome cytosolic small ribosomal subunit
YDR401W_d YDR401W YDR401W hom Dubious 0.756835234499408 0.224574290350078 no 1093 0.238602441774276 807 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YJL158C YJL158C CIS3 hom Verified 0.756776510412217 0.224591883927022 no 1094 0.206735302987605 696 NA FT CELL WALL ORG/BIOGENESIS ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family fungal-type cell wall organization structural constituent of cell wall extracellular region|fungal-type cell wall|endoplasmic reticulum|plasma membrane|cellular bud tip
YLR312C_p YLR312C YLR312C hom Uncharacterized 0.756147738927337 0.22478031115584 no 1095 0.217146024496527 744 NA Putative protein of unknown function biological_process molecular_function cellular_component
YNL187W YNL187W SWT21 hom Verified 0.756020963565851 0.224818313445285 no 1096 0.218700647530775 763 NA FT RNA PROCESSING NUCLEUS Protein involved in mRNA splicing; contains a consensus nuclear export signal (NES) sequence similar to the consensus sequence recognized by Crm1p; interacts genetically with Prp40p and Tgs1p; contains WD40 repeats mRNA splicing, via spliceosome molecular_function small nuclear ribonucleoprotein complex|nucleus
YOR062C_p YOR062C YOR062C hom Uncharacterized 0.755747867811654 0.2249001892336 no 1097 0.203662888544116 686 NA FT NUCLEUS Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS biological_process molecular_function nucleus|cytoplasm
YPR075C YPR075C OPY2 hom Verified 0.755660540309958 0.224926374122453 no 1098 0.20606166785872 714 NA FT CELL CYCLE|SIGNALING PLASMA MEMBRANE Integral membrane protein that acts as a membrane anchor for Ste50p; involved in the signaling branch of the high-osmolarity glycerol (HOG) pathway and as a regulator of the filamentous growth pathway; overproduction blocks cell cycle arrest in the presence of mating pheromone; relocalizes from vacuole to plasma membrane upon DNA replication stress cell cycle arrest in response to pheromone|osmosensory signaling pathway molecular_function integral to membrane|plasma membrane|fungal-type vacuole|cytoplasm
YCR077C YCR077C PAT1 hom Verified 0.75456261275324 0.225255731804967 no 1099 0.241901366029455 842 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|TRANSLATION|CELL DIVISION|CHROMOSOME SEGREGATION NUCLEUS RIBOSOME Deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; associated with topoisomerase II; functionally linked to Pab1p; forms cytoplasmic foci upon DNA replication stress deadenylation-dependent decapping of nuclear-transcribed mRNA|chromosome segregation|regulation of translational initiation|formation of translation preinitiation complex|negative regulation of translational initiation|cytoplasmic mRNA processing body assembly molecular_function cytosolic small ribosomal subunit|cytoplasmic mRNA processing body
YNR012W YNR012W URK1 hom Verified 0.753234725628358 0.225654437749267 no 1100 0.239991468604137 848 NA FT NUCLEOTIDE METABOLISM NUCLEUS Uridine/cytidine kinase, component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP; involved in the pyrimidine deoxyribonucleotide salvage pathway, converting deoxycytidine into dCMP pyrimidine-containing compound salvage uridine kinase activity nucleus|cytoplasm
YOR355W YOR355W GDS1 hom Verified 0.752452272286152 0.225889560820127 no 1101 0.238639895905814 845 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS|MITOCHONDRION Protein of unknown function, required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies aerobic respiration molecular_function mitochondrion|nucleus|cytoplasm
YHR153C YHR153C SPO16 hom Verified 0.752137021988084 0.225984330996759 no 1102 0.191575841915425 661 NA FT CELL CYCLE NUCLEUS|CHROMOSOME Meiosis-specific protein involved in synaptonemal complex assembly; implicated in regulation of crossover formation; required for sporulation synaptonemal complex assembly|ascospore formation|regulation of reciprocal meiotic recombination molecular_function condensed nuclear chromosome
YLR423C YLR423C ATG17 hom Verified 0.752066025942898 0.22600567684565 no 1103 0.239482500583633 831 NA FT MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION Scaffold protein responsible for phagophore assembly site organization; regulatory subunit of an autophagy-specific complex that includes Atg1p and Atg13p; stimulates Atg1p kinase activity; human ortholog RB1CC1/FIP200 interacts with p53, which inhibits autophagy in human cells piecemeal microautophagy of nucleus|mitochondrion degradation|peroxisome degradation|activation of protein kinase activity|autophagic vacuole assembly protein kinase activator activity|protein complex scaffold pre-autophagosomal structure|Atg1p signaling complex
YLR134W YLR134W PDC5 hom Verified 0.749865125536468 0.226667970180686 no 1104 0.220803927902918 740 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Minor isoform of pyruvate decarboxylase, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde, regulation is glucose- and ethanol-dependent, repressed by thiamine, involved in amino acid catabolism L-phenylalanine catabolic process|glucose catabolic process to ethanol|pyruvate metabolic process|tryptophan catabolic process|aromatic amino acid family catabolic process to alcohol via Ehrlich pathway pyruvate decarboxylase activity nucleus|cytoplasm
YNL145W YNL145W MFA2 hom Verified 0.749750679514514 0.226702439126904 no 1105 0.202605730750475 715 NA FT SIGNALING PLASMA MEMBRANE Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA1 pheromone-dependent signal transduction involved in conjugation with cellular fusion mating pheromone activity extracellular region
YLR361C YLR361C DCR2 hom Verified 0.746843714460759 0.227578952396387 no 1106 0.201343745287408 669 NA FT CELL CYCLE|SIGNALING Phosphoesterase involved in downregulation of the unfolded protein response, at least in part via dephosphorylation of Ire1p; dosage-dependent positive regulator of the G1/S phase transition through control of the timing of START endoplasmic reticulum unfolded protein response|traversing start control point of mitotic cell cycle|protein dephosphorylation hydrolase activity, acting on ester bonds|phosphoprotein phosphatase activity|phosphoric ester hydrolase activity cellular_component
YMR144W_p YMR144W YMR144W hom Uncharacterized 0.74663004413305 0.227643453851599 no 1107 0.222454876731953 736 NA FT NUCLEUS Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene biological_process molecular_function nucleus
YER002W YER002W NOP16 hom Verified 0.746154671526985 0.227786993259506 no 1108 0.242421681352926 812 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis ribosomal large subunit biogenesis molecular_function nucleolus|nucleus|preribosome, large subunit precursor
YDR317W YDR317W HIM1 hom Verified 0.746104276552167 0.227802213076599 no 1109 0.206126755498081 700 NA FT RESPONSE TO DNA DAMAGE Protein of unknown function involved in DNA repair DNA repair molecular_function cellular_component
YCR028C-A YCR028C-A RIM1 hom Verified 0.742937321278331 0.2287598144557 no 1110 0.272403877773619 906 NA FT MITOCHONDRION ORGANIZATION MITOCHONDRION Single-stranded DNA-binding protein essential for mitochondrial genome maintenance; involved in mitochondrial DNA replication mitochondrial DNA replication|mitochondrial genome maintenance single-stranded DNA binding mitochondrial nucleoid|mitochondrion
YPL023C YPL023C MET12 hom Verified 0.741532965275707 0.229185175805074 no 1111 0.237121303333743 799 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS Protein with methylenetetrahydrofolate reductase (MTHFR) activity in vitro; null mutant has no phenotype and is prototrophic for methionine; MET13 encodes major isozyme of MTHFR biological_process methylenetetrahydrofolate reductase (NADPH) activity cellular_component
YMR250W YMR250W GAD1 hom Verified 0.741310441293753 0.229252616139643 no 1112 0.236715532651252 833 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|RESPONSE TO OXIDATIVE STRESS Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress cellular response to oxidative stress|glutamate catabolic process calmodulin binding|glutamate decarboxylase activity cytoplasm
YIL029C_p YIL029C YIL029C hom Uncharacterized 0.741288413360729 0.229259292749667 no 1113 0.245589400769917 857 NA Putative protein of unknown function; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YIL029C has paralog YPR071W biological_process molecular_function integral to membrane
YIL089W YIL089W YIL089W hom Verified 0.741269636874778 0.229264983940491 no 1114 0.196450218300003 664 NA FT ENDOPLASMIC RETICULUM Protein of unknown function found in the ER and vacuole lumen; overexpression of YIL089W affects endocytic protein trafficking biological_process molecular_function fungal-type vacuole lumen|integral to membrane|endoplasmic reticulum
YBL045C YBL045C COR1 hom Verified 0.740120779302055 0.229613355656409 no 1115 0.240536719658514 793 NA FT OXIDATION-REDUCTION PROCESS|PROTEOLYSIS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Core subunit of the ubiquinol-cytochrome c reductase complex (bc1 complex), which is a component of the mitochondrial inner membrane electron transport chain aerobic respiration ubiquinol-cytochrome-c reductase activity mitochondrion|integral to membrane|mitochondrial respiratory chain complex III
YLR194C YLR194C YLR194C hom Verified 0.740052218936766 0.229634154805066 no 1116 0.226056941816693 755 NA FT CELL WALL ORG/BIOGENESIS PLASMA MEMBRANE Structural constituent of the cell wall attached to the plasma membrane by a GPI-anchor; expression is upregulated in response to cell wall stress fungal-type cell wall organization structural constituent of cell wall fungal-type cell wall|anchored to plasma membrane
YER153C YER153C PET122 hom Verified 0.736925683088397 0.230583772264438 no 1117 0.226584711176108 764 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet494p; located in the mitochondrial inner membrane positive regulation of mitochondrial translation|mitochondrial respiratory chain complex IV biogenesis translation initiation factor activity mitochondrion|mitochondrial inner membrane|integral to mitochondrial inner membrane
YKL156W YKL156W RPS27A hom Verified 0.734125224576793 0.231436210629153 no 1118 0.243617936228228 827 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27A has a paralog, RPS27B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress cytoplasmic translation|ribosomal small subunit assembly|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit|cytoplasm
YJL183W YJL183W MNN11 hom Verified 0.733368063073446 0.231666986264817 no 1119 0.262347206500599 886 NA FT CARBOHYDRATE METABOLISM GOLGI APPARATUS Subunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p protein glycosylation alpha-1,6-mannosyltransferase activity alpha-1,6-mannosyltransferase complex
YDR024W_d YDR024W FYV1 hom Dubious 0.733210768796823 0.231714944148711 no 1120 0.249990143828942 855 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; mutation decreases survival upon exposure to K1 killer toxin Unknown Unknown Unknown
YFL040W_p YFL040W YFL040W hom Uncharacterized 0.733101943976674 0.231748127284207 no 1121 0.221951695000602 716 NA Putative transporter, member of the sugar porter family; YFL040W is not an essential gene transmembrane transport substrate-specific transmembrane transporter activity integral to membrane|membrane
YPL180W YPL180W TCO89 hom Verified 0.732812011796668 0.231836547049421 no 1122 0.251865026851869 887 NA FT SIGNALING|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM PLASMA MEMBRANE Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p), a complex that regulates growth in response to nutrient availability; cooperates with Ssd1p in the maintenance of cellular integrity; deletion strains are hypersensitive to rapamycin TOR signaling cascade|fungal-type cell wall organization|response to salt stress|regulation of cell growth|glycerol metabolic process molecular_function TORC1 complex|fungal-type vacuole membrane|extrinsic to internal side of plasma membrane|extrinsic to vacuolar membrane
YGR279C YGR279C SCW4 hom Verified 0.732471312935824 0.231940472990755 no 1123 0.238410915943529 801 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating conjugation with cellular fusion glucosidase activity extracellular region|fungal-type cell wall
YIR042C_p YIR042C YIR042C hom Uncharacterized 0.732104149065749 0.232052500791852 no 1124 0.218554100240459 706 NA Putative protein of unknown function; YIR042C is a non-essential gene biological_process molecular_function cellular_component
YML081C-A YML081C-A ATP18 hom Verified 0.731580852596239 0.232212219294173 no 1125 0.216236646050624 720 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS MITOCHONDRION Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms mitochondrial proton-transporting ATP synthase complex assembly|ATP synthesis coupled proton transport hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism mitochondrion|mitochondrial proton-transporting ATP synthase complex|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
YPR077C_d YPR077C YPR077C hom Dubious 0.731232593292656 0.232318547532209 no 1126 0.235498716965149 805 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression increased by deletion of NAP1 Unknown Unknown Unknown
YDR338C_p YDR338C YDR338C hom Uncharacterized 0.730676428064486 0.23248840839292 no 1127 0.256822115620541 879 NA Putative protein of unknown function, member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily transmembrane transport antiporter activity integral to membrane
YCL074W YCL074W YCL074W hom pseudogene 0.730616481326439 0.23250672111135 no 1128 0.228136407506103 757 NA FT NUCLEUS Pseudogene: encodes fragment of Ty Pol protein transposition, RNA-mediated ribonuclease activity|peptidase activity|RNA binding|RNA-directed DNA polymerase activity|DNA-directed DNA polymerase activity retrotransposon nucleocapsid
YDR289C YDR289C RTT103 hom Verified 0.730284176514453 0.232608249178027 no 1129 0.252171904380343 873 NA FT RNA PROCESSING NUCLEUS|CHROMOSOME Protein that interacts with exonuclease Rat1p and Rai1p and plays a role in transcription termination by RNA polymerase II, has an RPR domain (carboxy-terminal domain interacting domain); also involved in regulation of Ty1 transposition negative regulation of transposition, RNA-mediated|mRNA 3'-end processing RNA polymerase II core binding nuclear chromatin|site of double-strand break
YEL046C YEL046C GLY1 hom Verified 0.730204506804089 0.23263259408176 no 1130 0.270979324008818 913 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Threonine aldolase, catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis threonine catabolic process|glycine biosynthetic process threonine aldolase activity|L-allo-threonine aldolase activity cytosol
YCR106W YCR106W RDS1 hom Verified 0.728310153409739 0.233211874174179 no 1131 0.215912397983124 780 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Putative zinc cluster transcription factor; involved in conferring resistance to cycloheximide response to xenobiotic stimulus sequence-specific DNA binding|DNA binding nucleus
YOR367W YOR367W SCP1 hom Verified 0.728280070974062 0.233221079627407 no 1132 0.251343622437973 888 NA FT CYTOSKELETON ORGANIZATION CYTOSKELETON Component of yeast cortical actin cytoskeleton, binds and cross links actin filaments; originally identified by its homology to calponin (contains a calponin-like repeat) but the Scp1p domain structure is more similar to transgelin actin filament organization|chronological cell aging actin filament binding|protein binding, bridging actin cortical patch
YDR435C YDR435C PPM1 hom Verified 0.727945630146531 0.233323434638235 no 1133 0.27159719152952 932 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS Carboxyl methyltransferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits cellular protein complex assembly|C-terminal protein methylation protein C-terminal leucine carboxyl O-methyltransferase activity cellular_component
YHR204W YHR204W MNL1 hom Verified 0.727566303664765 0.233439556985609 no 1134 0.228803016435342 820 NA FT PROTEOLYSIS ENDOPLASMIC RETICULUM Alpha-1,2-specific exomannosidase of the endoplasmic reticulum; in complex with Pdi1p, generates a Man7GlcNac2 oligosaccharide signal on glycoproteins destined for ubiquitin-proteasome degradation ER-associated protein catabolic process carbohydrate binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity endoplasmic reticulum lumen
YFL042C_p YFL042C YFL042C hom Uncharacterized 0.727374239293218 0.233498365435631 no 1135 0.239664343178987 778 NA Putative protein of unknown function; YFL042C is not an essential gene biological_process molecular_function cellular_component
YMR145C YMR145C NDE1 hom Verified 0.727352771468208 0.23350493920857 no 1136 0.232254334102521 782 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Mitochondrial external NADH dehydrogenase, a type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain glucose catabolic process to ethanol|NADH oxidation|chronological cell aging NADH dehydrogenase activity mitochondrion
YLR297W YLR297W YLR297W hom Verified 0.72728995217197 0.233524176017516 no 1137 0.227270235194217 780 NA Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; not an essential gene; induced by treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from nucleus to vacuole upon DNA replication stress; YLR297W has a paralog, YOR186W, that arose from the whole genome duplication biological_process molecular_function fungal-type vacuole
YGR137W_d YGR137W YGR137W hom Dubious 0.727133638402656 0.233572046941141 no 1138 0.226823069576781 758 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YHR001W-A YHR001W-A QCR10 hom Verified 0.726943552953803 0.233630267737004 no 1139 0.211554544553403 732 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Subunit of the ubiqunol-cytochrome c oxidoreductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration ubiquinol-cytochrome-c reductase activity mitochondrion|mitochondrial respiratory chain complex III
YMR105W-A_p YMR105W-A YMR105W-A hom Uncharacterized 0.726862543457 0.233655082377913 no 1140 0.270533881660108 937 NA Putative protein of unknown function biological_process molecular_function cellular_component
YHR029C YHR029C YHI9 hom Verified 0.726180774448984 0.233863978164688 no 1141 0.246309510494933 818 NA FT SIGNALING Protein of unknown function; null mutant is defective in unfolded protein response; possibly involved in a membrane regulation metabolic pathway; member of the PhzF superfamily, though most likely not involved in phenazine production endoplasmic reticulum unfolded protein response molecular_function cellular_component
YGL125W YGL125W MET13 hom Verified 0.725269277084613 0.234143424912123 no 1142 0.24555789986546 793 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION Major isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway methionine biosynthetic process methylenetetrahydrofolate reductase (NADPH) activity mitochondrion
YDR169C YDR169C STB3 hom Verified 0.724790890837237 0.234290162460524 no 1143 0.214083276815531 713 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS NUCLEUS Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress positive regulation of transcription from RNA polymerase II promoter by glucose sequence-specific DNA binding nucleus|cytoplasm
YGL199C_d YGL199C YGL199C hom Dubious 0.724301104932464 0.234440449397068 no 1144 0.204394238373481 678 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YIP4/YGL198W Unknown Unknown Unknown
YNL170W_d YNL170W YNL170W hom Dubious 0.724231426748493 0.234461833930514 no 1145 0.242861052050318 879 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDL059C YDL059C RAD59 hom Verified 0.722508932308084 0.234990817818975 no 1146 0.253041299570641 883 NA FT RESPONSE TO DNA DAMAGE NUCLEUS Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p DNA strand renaturation|telomere maintenance via recombination|double-strand break repair via break-induced replication|double-strand break repair via single-strand annealing protein binding nucleus
YAR015W YAR015W ADE1 hom Verified 0.721827124329456 0.235200385383045 no 1147 0.232523780629047 818 NA FT NUCLEOTIDE METABOLISM NUCLEUS N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase, required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine; protein abundance increases in response to DNA replication stress purine nucleotide biosynthetic process|'de novo' IMP biosynthetic process phosphoribosylaminoimidazolesuccinocarboxamide synthase activity nucleus|cytoplasm
YPL078C YPL078C ATP4 hom Verified 0.720528682304388 0.235599773245652 no 1148 0.234866123806622 796 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS MITOCHONDRION Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; contributes to the oligomerization of the complex; phosphorylated protein complex oligomerization|ATP synthesis coupled proton transport proton-transporting ATPase activity, rotational mechanism mitochondrion|mitochondrial proton-transporting ATP synthase, stator stalk|integral to membrane
YBL022C YBL022C PIM1 hom Verified 0.719087027236865 0.236043649952321 no 1149 0.282008488486581 959 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION|RESPONSE TO OXIDATIVE STRESS MITOCHONDRION ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria chaperone-mediated protein complex assembly|misfolded or incompletely synthesized protein catabolic process ATP-dependent peptidase activity mitochondrion|mitochondrial matrix
YOL083W YOL083W ATG34 hom Verified 0.71887901942826 0.236107732290618 no 1150 0.217142811106966 696 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS Receptor protein involved in selective autophagy during starvation; specifically involved in the transport of cargo protein alpha-mannosidase (Ams1p); Atg19p paralog protein complex assembly|protein complex localization protein binding, bridging CVT complex
YJL038C YJL038C LOH1 hom Verified 0.718701227976225 0.236162513272668 no 1151 0.240872452065143 821 NA Protein of unknown function with proposed roles in maintenance of genome integrity and also in spore wall assembly; induced during sporulation; repressed during vegetative growth by Sum1p and Hst1p; sequence similar to IRC1 chromosome organization molecular_function cellular_component
YMR075W YMR075W RCO1 hom Verified 0.71846221554752 0.236236168651585 no 1152 0.242717321366375 836 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p regulation of DNA-dependent DNA replication initiation|negative regulation of antisense RNA transcription|transcription elongation from RNA polymerase II promoter|histone deacetylation molecular_function Rpd3S complex|histone deacetylase complex|nucleus|Rpd3L complex
YDL180W_p YDL180W YDL180W hom Uncharacterized 0.718347609724863 0.236271490696427 no 1153 0.23982496632389 829 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole biological_process molecular_function integral to membrane|fungal-type vacuole
YIL161W_p YIL161W YIL161W hom Uncharacterized 0.717142257951677 0.236643161777952 no 1154 0.215144590652194 740 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; mRNA is enriched in Scp160p-associated mRNPs; YIL161W is a non-essential gene biological_process molecular_function cytoplasm
YFL048C YFL048C EMP47 hom Verified 0.716154836444771 0.236947873417069 no 1155 0.23332697734923 813 NA FT VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport ER to Golgi vesicle-mediated transport glycoprotein binding fungal-type vacuole membrane|integral to endoplasmic reticulum membrane|integral to Golgi membrane|ER to Golgi transport vesicle
YPL097W YPL097W MSY1 hom Verified 0.715633951244457 0.237108701943196 no 1156 0.24914606708559 855 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial tyrosyl-tRNA synthetase mitochondrial tyrosyl-tRNA aminoacylation tyrosine-tRNA ligase activity mitochondrion
YDL061C YDL061C RPS29B hom Verified 0.715587168588522 0.237123149491962 no 1157 0.221898229911315 763 NA FT TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29B has a paralog, RPS29A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic small ribosomal subunit
YPL249C YPL249C GYP5 hom Verified 0.714765737944976 0.237376904757421 no 1158 0.220797278308533 710 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM GOLGI APPARATUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress vesicle-mediated transport|ER to Golgi vesicle-mediated transport Rab GTPase activator activity cytosol|incipient cellular bud site|plasma membrane|cellular bud neck|Golgi-associated vesicle|cellular bud tip
YNL321W YNL321W VNX1 hom Verified 0.71435625174868 0.237503458359433 no 1159 0.249671811499069 876 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Calcium/H+ antiporter localized to the endoplasmic reticulum membrane; member of the calcium exchanger (CAX) family; potential Cdc28p substrate potassium ion transport|sodium ion transport|hydrogen transport potassium:hydrogen antiporter activity|sodium:hydrogen antiporter activity|calcium:hydrogen antiporter activity fungal-type vacuole membrane|integral to membrane|endoplasmic reticulum membrane|fungal-type vacuole
YHR131C_p YHR131C YHR131C hom Uncharacterized 0.713306037470942 0.237828201160963 no 1160 0.21134499234525 691 NA Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; overexpression causes cell cycle delay or arrest; contains a PH domain and binds phosphatidylinositols and other lipids in a large-scale study biological_process molecular_function cytoplasm
YJR014W YJR014W TMA22 hom Verified 0.712042637192285 0.238219186896591 no 1161 0.180548634465763 608 NA FT TRANSLATION RIBOSOME Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1; protein abundance increases in response to DNA replication stress biological_process RNA binding ribosome|cytoplasm
YLR123C_d YLR123C YLR123C hom Dubious 0.710740748754282 0.23862245172779 no 1162 0.21273277608481 720 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif Unknown Unknown Unknown
YGR129W YGR129W SYF2 hom Verified 0.710367382488315 0.238738172228612 no 1163 0.263556389788451 919 NA FT RNA PROCESSING NUCLEUS Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; isy1 syf2 cells have defective spindles activiating cell cycle arrest mRNA splicing, via spliceosome first spliceosomal transesterification activity|second spliceosomal transesterification activity U2-type post-mRNA release spliceosomal complex|Prp19 complex|U2-type prespliceosome|U2-type catalytic step 2 spliceosome|U2-type catalytic step 1 spliceosome
YKL161C YKL161C KDX1 hom Verified 0.709909931599152 0.238879995616924 no 1164 0.261506851165496 899 NA FT PROTEIN PHOSPHORYLATION Protein kinase implicated in the Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p biological_process protein kinase activity cellular_component
YKR095W YKR095W MLP1 hom Verified 0.709413250662707 0.239034033646262 no 1165 0.232204921089106 741 NA FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs protein localization to nuclear pore|poly(A)+ mRNA export from nucleus|protein import into nucleus|transcriptional activation by promoter-terminator looping|nuclear retention of unspliced pre-mRNA at the site of transcription|telomere tethering at nuclear periphery ribonucleoprotein complex binding nucleoplasm|nuclear envelope|integral to membrane|ribonucleoprotein complex|spindle pole body
YDL023C_d YDL023C YDL023C hom Dubious 0.707095610704381 0.23975353173757 no 1166 0.251928549005626 872 NA Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance Unknown Unknown Unknown
YDR349C YDR349C YPS7 hom Verified 0.706664681743115 0.239887441337625 no 1167 0.243357070554117 839 NA FT CELL WALL ORG/BIOGENESIS|PROTEOLYSIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Putative GPI-anchored aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; located in the cytoplasm and endoplasmic reticulum fungal-type cell wall organization aspartic-type endopeptidase activity endoplasmic reticulum|cytoplasm
YBR185C YBR185C MBA1 hom Verified 0.706401872912853 0.239969128243328 no 1168 0.241551508810787 801 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Membrane-associated mitochondrial ribosome receptor; forms a complex with Mdm38p that may facilitate recruitment of mRNA-specific translational activators to ribosomes; possible role in protein export from the matrix to inner membrane protein insertion into mitochondrial membrane from inner side|mitochondrial respiratory chain complex III biogenesis|inner mitochondrial membrane organization|positive regulation of mitochondrial translation|mitochondrial respiratory chain complex IV biogenesis ribosome binding mitochondrion|mitochondrial inner membrane
YGL216W YGL216W KIP3 hom Verified 0.706133607089764 0.24005252694745 no 1169 0.209299156860543 721 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CYTOSKELETON ORGANIZATION NUCLEUS|CYTOSKELETON Kinesin-related motor protein involved in mitotic spindle positioning nuclear migration along microtubule|mitotic spindle disassembly|establishment of mitotic spindle orientation|plus-end specific microtubule depolymerization|mitotic spindle organization in nucleus plus-end-directed microtubule motor activity|tubulin-dependent ATPase activity kinesin complex|cytoplasmic microtubule|nuclear microtubule
YPL019C YPL019C VTC3 hom Verified 0.706102762352378 0.240062116998096 no 1170 0.212420710635662 720 NA FT MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT ENDOPLASMIC RETICULUM Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion polyphosphate metabolic process|vacuolar transport|microautophagy|vacuole fusion, non-autophagic molecular_function fungal-type vacuole membrane|integral to membrane|vacuolar transporter chaperone complex|endoplasmic reticulum
YIL173W YIL173W VTH1 hom Verified 0.705770471101019 0.240165444136754 no 1171 0.211888539555342 700 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT GOLGI APPARATUS Putative membrane glycoprotein with strong similarity to Vth2p and Pep1p/Vps10p, may be involved in vacuolar protein sorting Golgi to vacuole transport signal sequence binding endosome|integral to membrane
YDR387C_p YDR387C YDR387C hom Uncharacterized 0.704522468663861 0.240553731294804 no 1172 0.213549273352145 723 NA Putative transporter, member of the sugar porter family; YDR387C is not an essential gene transport|transmembrane transport substrate-specific transmembrane transporter activity integral to membrane|membrane
YGR180C YGR180C RNR4 hom Verified 0.704362512797843 0.240603522571138 no 1173 0.278881066269757 930 NA FT OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM NUCLEUS Ribonucleotide-diphosphate reductase (RNR) small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits; relocalizes from nucleus to cytoplasm upon DNA replication stress cofactor biosynthetic process|deoxyribonucleotide biosynthetic process ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor ribonucleoside-diphosphate reductase complex|nucleus|cytoplasm
YBR074W_p YBR074W YBR074W hom Uncharacterized 0.703732296890796 0.24079975161235 no 1174 0.256056194863363 904 NA FT PROTEOLYSIS Putative metalloprotease biological_process molecular_function cellular_component
YLR027C YLR027C AAT2 hom Verified 0.70155339444283 0.241478862515392 no 1175 0.286379088351607 941 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells aspartate biosynthetic process L-aspartate:2-oxoglutarate aminotransferase activity cytosol|peroxisome
YML060W YML060W OGG1 hom Verified 0.701164575765616 0.241600157123022 no 1176 0.238668298854213 837 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA, contributes to UVA resistance DNA repair|base-excision repair, AP site formation oxidized purine nucleobase lesion DNA N-glycosylase activity mitochondrion
YCR010C YCR010C ADY2 hom Verified 0.699695264910292 0.242058817101663 no 1177 0.258561605929515 888 NA FT CELL CYCLE|ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION|PLASMA MEMBRANE Acetate transporter required for normal sporulation; phosphorylated in mitochondria; ADY2 has a paralog, ATO2, that arose from the whole genome duplication nitrogen utilization|ammonium transport|acetate transport|transmembrane transport acetate transmembrane transporter activity|ammonium transmembrane transporter activity mitochondrion|integral to membrane|plasma membrane
YNL168C_p YNL168C FMP41 hom Uncharacterized 0.698296960546017 0.242495749835237 no 1178 0.225655662734921 760 NA FT MITOCHONDRION Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YJR032W YJR032W CPR7 hom Verified 0.697529210835643 0.242735832643602 no 1179 0.257370383082107 917 NA Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity protein refolding|response to stress unfolded protein binding|peptidyl-prolyl cis-trans isomerase activity cytosol
YJL099W YJL099W CHS6 hom Verified 0.696114291015042 0.243178628698871 no 1180 0.266010886704561 941 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM GOLGI APPARATUS Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication Golgi to plasma membrane transport|fungal-type cell wall chitin biosynthetic process molecular_function trans-Golgi network transport vesicle|clathrin-coated vesicle|exomer complex
YJR082C YJR082C EAF6 hom Verified 0.695589424992759 0.243342995346889 no 1181 0.224207884031421 749 NA FT CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS HISTONE ACETYLTRANSFERASE Subunit of the NuA4 acetyltransferase complex that acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3 DNA repair|histone acetylation histone acetyltransferase activity nucleus|NuA4 histone acetyltransferase complex|NuA3 histone acetyltransferase complex
YNL035C YNL035C YNL035C hom Verified 0.695352134260895 0.243417324836262 no 1182 0.217044406354764 735 NA FT NUCLEUS Protein of unknown function; contains WD-40 domains; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YNL035C is not an essential gene; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus
YDR215C_d YDR215C YDR215C hom Dubious 0.69525005275542 0.243449304852934 no 1183 0.244738006232312 789 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein Unknown Unknown Unknown
YER175W-A_p YER175W-A YER175W-A hom Uncharacterized 0.69513093790303 0.243486623933078 no 1184 0.235903463722936 830 NA Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YBR182C YBR182C SMP1 hom Verified 0.695110119801165 0.243493146631001 no 1185 0.227582748672058 808 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Putative transcription factor of the MADS-box family; involved in regulating the response to osmotic stress; SMP1 has a paralog, RLM1, that arose from the whole genome duplication positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress DNA binding, bending|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nucleus|cytoplasm
YDR059C YDR059C UBC5 hom Verified 0.695049167311398 0.243512244720727 no 1186 0.243081354353611 809 NA Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived, abnormal, or excess proteins, including histone H3; central component of the cellular stress response; expression is heat inducible; protein abundance increases in response to DNA replication stress; UBC5 has a paralog, UBC4, that arose from the whole genome duplication protein polyubiquitination|response to stress ubiquitin-protein ligase activity proteasome complex
YLR247C YLR247C IRC20 hom Verified 0.694745808750302 0.243607307326359 no 1187 0.216019557793503 753 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION Putative helicase; localizes to the mitochondrion and the nucleus; YLR247C is not an essential gene; null mutant displays increased levels of spontaneous Rad52p foci double-strand break repair via synthesis-dependent strand annealing helicase activity mitochondrion|nucleus
YDR061W_p YDR061W YDR061W hom Uncharacterized 0.694482763769235 0.243689753200763 no 1188 0.250259068518565 841 NA FT NUCLEOTIDE METABOLISM MITOCHONDRION Protein with similarity to ATP-binding cassette (ABC) transporter family members; lacks predicted membrane-spanning regions; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance biological_process molecular_function mitochondrion
YOR047C YOR047C STD1 hom Verified 0.694392047493529 0.243718189787969 no 1189 0.250012401603582 846 NA FT TRANSCRIPTION FROM RNA POL II|SIGNALING|CARBOHYDRATE METABOLISM NUCLEUS|PLASMA MEMBRANE Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+] response to salt stress|signal transduction|nicotinamide riboside biosynthetic process|glucose metabolic process|nicotinic acid riboside biosynthetic process|regulation of transcription from RNA polymerase II promoter protein kinase activator activity plasma membrane|nucleus
YLR139C YLR139C SLS1 hom Verified 0.694174428728739 0.24378641346021 no 1190 0.270481347421452 916 NA FT TRANSLATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Mitochondrial membrane protein that coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translation machinery aerobic respiration|mitochondrial translation molecular_function mitochondrial nucleoid|mitochondrion|integral to membrane|mitochondrial inner membrane
YPL150W_p YPL150W YPL150W hom Uncharacterized 0.693306939070905 0.244058474641502 no 1191 0.213323408446757 714 NA FT PROTEIN PHOSPHORYLATION Protein kinase of unknown cellular role; binds phosphatidylinositols and cardiolipin in a large-scale study protein phosphorylation protein kinase activity cellular_component
YLR320W YLR320W MMS22 hom Verified 0.693161021099988 0.244104253364122 no 1192 0.245394227804462 843 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS UBIQUITIN LIGASE COMPLEX Subunit of an E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of the replication fork, such as the fork-pausing complex and leading strand polymerase, preventing fork collapse and promoting efficient recovery during replication stress; required for accurate meiotic chromosome segregation replication fork processing|double-strand break repair|recombinational repair|meiotic sister chromatid segregation|response to DNA damage stimulus molecular_function Cul8-RING ubiquitin ligase complex|nucleus
YNL206C YNL206C RTT106 hom Verified 0.693155966750577 0.2441058391439 no 1193 0.257717158561672 904 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Histone chaperone, involved in regulation of chromatin structure in both transcribed and silenced chromosomal regions; affects transcriptional elongation; has a role in regulation of Ty1 transposition DNA replication-independent nucleosome assembly|negative regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|DNA replication-dependent nucleosome assembly|heterochromatin assembly involved in chromatin silencing double-stranded DNA binding|histone binding nucleus
YJR061W_p YJR061W YJR061W hom Uncharacterized 0.692970767543174 0.244163948407479 no 1194 0.249342948919454 846 NA Putative protein of unknown function; non-essential gene; transcription repressed by Rm101p; YJR061W has a paralog, MNN4, that arose from the whole genome duplication biological_process molecular_function cellular_component
YPL277C_p YPL277C YPL277C hom Uncharacterized 0.692715537938838 0.24424404306846 no 1195 0.229140517550761 786 NA Putative protein of unknown function; localized to the membranes; gene expression regulated by copper levels biological_process molecular_function membrane
YFL034W_p YFL034W YFL034W hom Uncharacterized 0.691182697990667 0.244725367768269 no 1196 0.248451313418341 881 NA Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk biological_process molecular_function integral to membrane
YLR271W_p YLR271W YLR271W hom Uncharacterized 0.691094572832655 0.244753055328249 no 1197 0.223792906874136 752 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS biological_process molecular_function nucleus|cytoplasm
YDR306C_p YDR306C YDR306C hom Uncharacterized 0.690617434006331 0.244902994237903 no 1198 0.261514714120956 889 NA FT PROTEOLYSIS F-box protein of unknown function; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity|protein binding, bridging SCF ubiquitin ligase complex
YMR058W YMR058W FET3 hom Verified 0.690502834534644 0.244939014009949 no 1199 0.259857291089219 873 NA FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS PLASMA MEMBRANE Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress iron assimilation by reduction and transport|high-affinity iron ion transport|response to copper ion ferroxidase activity|iron ion transmembrane transporter activity integral to membrane|high affinity iron permease complex|plasma membrane
YGR035W-A_p YGR035W-A YGR035W-A hom Uncharacterized 0.690267822855698 0.245012889471623 no 1200 0.225134753293456 743 NA Putative protein of unknown function biological_process molecular_function cellular_component
YGL131C YGL131C SNT2 hom Verified 0.689594871769536 0.245224496617821 no 1201 0.234213650201566 810 NA FT NUCLEUS|CHROMOSOME DNA binding protein with similarity to the S. pombe Snt2 protein; RING finger ubiquitin ligase (E3) involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p; null mutant sensitive to hydroxyurea (HU); computational analysis suggests that Snt2p is a transcription factor with a role in regulation of expression of genes encoding amine transporters; relocalizes from nucleus to cytoplasm upon DNA replication stress biological_process DNA binding nucleus|Snt2C complex|cytoplasm
YML034W YML034W SRC1 hom Verified 0.688500878913149 0.245568708500746 no 1202 0.276855296763677 964 NA FF|FT CELL CYCLE|CHROMOSOME SEGREGATION ENDOMEMBRANE SYSTEM|NUCLEUS Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance maintenance of rDNA|mitotic sister chromatid segregation molecular_function nuclear envelope
YOL019W_p YOL019W YOL019W hom Uncharacterized 0.688011815887468 0.245722670286894 no 1203 0.255238416584908 872 NA FT PLASMA MEMBRANE Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole; YOL019W has a paralog, DCV1, that arose from the whole genome duplication biological_process molecular_function integral to membrane|plasma membrane|fungal-type vacuole
YGL170C YGL170C SPO74 hom Verified 0.687938173247361 0.245745858193537 no 1204 0.248685427287233 863 NA FT NUCLEUS|CYTOSKELETON Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation ascospore formation structural molecule activity spindle pole body
YMR279C YMR279C YMR279C hom Verified 0.687685513207155 0.245825422355914 no 1205 0.260768732547233 900 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Putative boron transporter involved in boron efflux and resistance; overexpression mutant but not null mutant displays boron tolerance phenotype; identified as a heat-induced gene in a high-throughout screen; YMR279C is not an essential gene; YMR279C has a paralog, ATR1, that arose from the whole genome duplication borate transmembrane transport borate efflux transmembrane transporter activity integral to membrane
YER142C YER142C MAG1 hom Verified 0.686169638048101 0.246303070749264 no 1206 0.222843279271678 752 NA FT RESPONSE TO DNA DAMAGE NUCLEUS 3-methyl-adenine DNA glycosylase; involved in protecting DNA against alkylating agents; initiates base excision repair by removing damaged bases to create abasic sites that are subsequently repaired; protein abundance increases in response to DNA replication stress base-excision repair, AP site formation|DNA dealkylation involved in DNA repair alkylbase DNA N-glycosylase activity nucleus
YNR018W YNR018W RCF2 hom Verified 0.685370240456751 0.246555159114337 no 1207 0.238392456685893 792 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast mitochondrial respiratory chain complex IV assembly molecular_function mitochondrion|mitochondrial respiratory chain supercomplex|mitochondrial respiratory chain complex IV|integral to mitochondrial inner membrane
YAL036C YAL036C RBG1 hom Verified 0.683859537367229 0.247031933354055 no 1208 0.249996019440224 859 NA FT TRANSLATION RIBOSOME Member of the DRG family of GTP-binding proteins; associates with translating ribosomes; interacts with Tma46p, Ygr250cp, Gir2p and Yap1p via two-hybrid cytoplasmic translation GTP binding polysomal ribosome|polysome|cytoplasm
YGR242W_d YGR242W YGR242W hom Dubious 0.682562468837702 0.247441678270844 no 1209 0.249368113946927 852 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C Unknown Unknown Unknown
YBR184W_p YBR184W YBR184W hom Uncharacterized 0.682430937712734 0.247483249324805 no 1210 0.242553014326775 868 NA Putative protein of unknown function; YBR184W is not an essential gene biological_process molecular_function cellular_component
YGR059W YGR059W SPR3 hom Verified 0.68141706507057 0.247803813935303 no 1211 0.245838237208927 831 NA FT CELL CYCLE SITE OF POLARIZED GROWTH|CYTOSKELETON Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; septin protein involved in sporulation; regulated by ABFI ascospore formation structural molecule activity septin complex|ascospore wall|prospore membrane
YIR027C YIR027C DAL1 hom Verified 0.681360386147375 0.247821741125858 no 1212 0.262062758826651 906 NA Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression allantoin assimilation pathway allantoinase activity cellular_component
YER097W_d YER097W YER097W hom Dubious 0.681235753488067 0.247861164095084 no 1213 0.290188546067535 990 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YIL057C YIL057C RGI2 hom Verified 0.678995172295583 0.248570460432878 no 1214 0.265502808938772 915 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY Protein of unknown function involved in energy metabolism under respiratory conditions; expression induced under carbon limitation and repressed under high glucose energy reserve metabolic process molecular_function cytoplasm
YIL141W_d YIL141W YIL141W hom Dubious 0.678829979911001 0.24862279782578 no 1215 0.240469437664292 856 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YFR006W_p YFR006W YFR006W hom Uncharacterized 0.678608949374578 0.248692835428231 no 1216 0.24182678301207 852 NA Putative X-Pro aminopeptidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YFR006W is not an essential gene biological_process molecular_function cytoplasm
YFL033C YFL033C RIM15 hom Verified 0.67734888388044 0.249092311034792 no 1217 0.241054868375477 806 NA FT CELL CYCLE|SIGNALING|PROTEIN PHOSPHORYLATION|RESPONSE TO OXIDATIVE STRESS NUCLEUS Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase protein phosphorylation|age-dependent response to oxidative stress involved in chronological cell aging|response to stress|regulation of meiosis protein serine/threonine kinase activity|protein kinase activity nucleus|cytoplasm
YDR516C YDR516C EMI2 hom Verified 0.676766046822315 0.249277201896094 no 1218 0.24023709878404 795 NA FT TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression regulated by glucose-repression transcription factors Mig1/2p; EMI2 has a paralog, GLK1, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress ascospore formation|positive regulation of transcription from RNA polymerase II promoter molecular_function cytoplasm
YBR168W YBR168W PEX32 hom Verified 0.676582021352817 0.249335594647422 no 1219 0.262353962482413 925 NA FT PEROXISOME ORGANIZATION Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p peroxisome organization molecular_function integral to membrane|integral to peroxisomal membrane
YHR103W YHR103W SBE22 hom Verified 0.676440841227112 0.249380397157679 no 1220 0.252869563804607 863 NA FT PROTEIN LOCALIZATION|CELL WALL ORG/BIOGENESIS GOLGI APPARATUS Protein involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; involved in bud growth fungal-type cell wall organization molecular_function cytoplasm
YDR476C_p YDR476C YDR476C hom Uncharacterized 0.676392660319069 0.249395688005997 no 1221 0.237563669577109 812 NA FT ENDOPLASMIC RETICULUM Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR476C is not an essential gene biological_process molecular_function endoplasmic reticulum
YGL205W YGL205W POX1 hom Verified 0.676168279082636 0.249466904922558 no 1222 0.219704505749678 751 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix fatty acid beta-oxidation using acyl-CoA oxidase|fatty acid beta-oxidation acyl-CoA oxidase activity peroxisomal matrix
YGR261C YGR261C APL6 hom Verified 0.675627867129646 0.249638471960531 no 1223 0.280013203028637 972 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools vesicle-mediated transport|Golgi to vacuole transport molecular_function AP-3 adaptor complex
YOR221C YOR221C MCT1 hom Verified 0.674490759476595 0.249999679274407 no 1224 0.290163746482148 1011 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Predicted malonyl-CoA:ACP transferase, putative component of a type-II mitochondrial fatty acid synthase that produces intermediates for phospholipid remodeling fatty acid metabolic process|aerobic respiration [acyl-carrier-protein] S-malonyltransferase activity mitochondrion
YLL061W YLL061W MMP1 hom Verified 0.672966245497699 0.250484382744586 no 1225 0.239170744980755 816 NA FT ENDOPLASMIC RETICULUM|PLASMA MEMBRANE High-affinity S-methylmethionine permease, required for utilization of S-methylmethionine as a sulfur source; has similarity to S-adenosylmethionine permease Sam3p S-methylmethionine transport S-methylmethionine transmembrane transporter activity integral to membrane|plasma membrane
YBR158W YBR158W AMN1 hom Verified 0.672800638984428 0.250537065594567 no 1226 0.265579746333385 931 NA FT CELL CYCLE|CELL DIVISION NUCLEUS Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN) mitotic cell cycle checkpoint|negative regulation of exit from mitosis protein binding nucleus|cellular bud|cytoplasm
YOR188W YOR188W MSB1 hom Verified 0.672621692324391 0.250593998819157 no 1227 0.294020376810796 1043 NA FT MITOCHONDRION|SITE OF POLARIZED GROWTH Protein of unknown function; may be involved in positive regulation of 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4; potential Cdc28p substrate; relocalizes from bud neck to cytoplasm upon DNA replication stress establishment of cell polarity molecular_function mitochondrion|cellular bud neck|cellular bud tip
YKR080W YKR080W MTD1 hom Verified 0.672358509078787 0.250677744997534 no 1228 0.261453915228026 871 NA FT OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM NUCLEUS NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline folic acid-containing compound biosynthetic process|one-carbon metabolic process|purine nucleobase biosynthetic process methylenetetrahydrofolate dehydrogenase (NAD+) activity cytosol
YJL207C YJL207C LAA1 hom Verified 0.671822789571296 0.250848259313356 no 1229 0.253345000720511 855 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene protein localization|retrograde transport, endosome to Golgi molecular_function AP-1 adaptor complex|ribosome|clathrin-coated vesicle
YMR267W YMR267W PPA2 hom Verified 0.671798495877355 0.250855993215226 no 1230 0.274086675321129 932 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate aerobic respiration inorganic diphosphatase activity mitochondrion
YGL242C_p YGL242C YGL242C hom Uncharacterized 0.671766373476083 0.250866219581283 no 1231 0.2722597742224 921 NA Putative protein of unknown function; deletion mutant is viable biological_process molecular_function cellular_component
YER163C YER163C GCG1 hom Verified 0.671542435168812 0.250937517864311 no 1232 0.249194424262065 843 NA FT NUCLEUS Gamma-glutamyl cyclotransferase; cleaves the gamma-glutamyl bond of glutathione to yield 5-oxoproline and a Cys-Gly dipeptide; similar to mammalian pro-apoptotic protein ChaC1; expression of mouse ChaC1 in yeast increases apoptosis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; periodically expressed during the metabolic cycle biological_process molecular_function nucleus|cytoplasm
YDL091C YDL091C UBX3 hom Verified 0.670302146710597 0.251332599466131 no 1233 0.232909803603658 741 NA Subunit of the DSC ubiquitin ligase complex; UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; ortholog of fission yeast Ucp10 biological_process molecular_function cytoplasm
YDR126W YDR126W SWF1 hom Verified 0.667443282352734 0.252244513451894 no 1234 0.268048733116967 904 NA FF|FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|CYTOSKELETON Palmitoyltransferase that acts on transmembrane proteins, including the SNAREs Snc1p, Syn8p, Tlg1p and likely all SNAREs; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; may have a role in vacuole fusion ascospore wall assembly|cortical actin cytoskeleton organization|establishment of cell polarity|vacuole fusion, non-autophagic|regulation of exocytosis|protein palmitoylation palmitoyltransferase activity integral to membrane|actin filament bundle|nuclear outer membrane-endoplasmic reticulum membrane network|actin cortical patch
YDR409W YDR409W SIZ1 hom Verified 0.666888869438465 0.252421560572458 no 1235 0.251630312657888 837 NA FT CHROMOSOME SEGREGATION NUCLEUS|SITE OF POLARIZED GROWTH|CHROMOSOME|CYTOSKELETON SUMO/Smt3 ligase that promotes the attachment of sumo (Smt3p; small ubiquitin-related modifier) to proteins; binds Ubc9p and may bind septins; specifically required for sumoylation of septins in vivo; localized to the septin ring protein sumoylation|chromosome segregation SUMO ligase activity nuclear chromatin|septin ring
YIL148W YIL148W RPL40A hom Verified 0.666375745032552 0.252585480894179 no 1236 0.260043478509016 874 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RESPONSE TO DNA DAMAGE|TRANSLATION NUCLEUS RIBOSOME Ubiquitin-ribosomal 60S subunit protein L40A fusion protein; cleaved to yield ubiquitin and ribosomal protein L40A; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40A has a paralog, RPL40B, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress cytoplasmic translation|protein ubiquitination|ribosome biogenesis structural constituent of ribosome|protein tag cytosolic large ribosomal subunit
YOR104W YOR104W PIN2 hom Verified 0.665436786209283 0.252885581417304 no 1237 0.262663368868376 898 NA Protein that induces appearance of [PIN+] prion when overproduced; predicted to be palmitoylated biological_process molecular_function cellular_component
YPL149W YPL149W ATG5 hom Verified 0.665262056902829 0.252941447335163 no 1238 0.235098460249386 808 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Conserved protein involved in autophagy and the Cvt pathway; undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation; conjugated Atg12p also forms a complex with Atg16p that is essential for autophagosome formation C-terminal protein lipidation|mitochondrion degradation|piecemeal microautophagy of nucleus|macroautophagy|CVT pathway Atg8 ligase activity cytosol|Atg12-Atg5-Atg16 complex|pre-autophagosomal structure|autophagic vacuole
YBR260C YBR260C RGD1 hom Verified 0.663413133224101 0.253532998464963 no 1239 0.23116967896481 766 NA FT SIGNALING SITE OF POLARIZED GROWTH|CYTOSKELETON GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization response to acid|osmosensory signaling pathway Rho GTPase activator activity|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding cellular bud|mating projection tip|actin cortical patch
YDR214W YDR214W AHA1 hom Verified 0.662053493675921 0.253968469640358 no 1240 0.264439885456424 896 NA FT NUCLEOTIDE METABOLISM Co-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is regulated by stresses such as heat shock; protein abundance increases in response to DNA replication stress protein folding|response to stress ATPase activator activity|chaperone binding cytoplasm
YGR288W YGR288W MAL13 hom Verified 0.660130502104714 0.254585043072992 no 1241 0.255310247501054 869 NA FT TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM NUCLEUS MAL-activator protein, part of complex locus MAL1; nonfunctional in genomic reference strain S288C cellular carbohydrate metabolic process|regulation of transcription, DNA-dependent sequence-specific DNA binding transcription factor activity nucleus
YNL180C YNL180C RHO5 hom Verified 0.659917404353107 0.254653417347108 no 1242 0.256813533227861 878 NA FT SIGNALING NUCLEUS|PLASMA MEMBRANE Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity Rho protein signal transduction GTPase activity endomembrane system|fungal-type vacuole membrane|plasma membrane|nucleus|cytoplasm
YHR003C YHR003C YHR003C hom Verified 0.659795265098356 0.254692611128701 no 1243 0.211683427539004 695 NA FT MITOCHONDRION Protein of unknown function, localized to the mitochondrial outer membrane biological_process molecular_function mitochondrial outer membrane|mitochondrion
YCR047C YCR047C BUD23 hom Verified 0.65842438380641 0.255132735624973 no 1244 0.240538285814167 844 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|CELL DIVISION NUCLEUS Methyltransferase, methylates residue G1575 of 18S rRNA; required for rRNA processing and nuclear export of 40S ribosomal subunits independently of methylation activity; diploid mutant displays random budding pattern endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA (guanine-N7)-methylation|cellular bud site selection|ribosomal small subunit export from nucleus S-adenosylmethionine-dependent methyltransferase activity|rRNA (guanine) methyltransferase activity nucleolus|nucleus|cytoplasm
YIL041W YIL041W GVP36 hom Verified 0.657513031525937 0.255425547271009 no 1245 0.273090329837435 929 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION ENDOMEMBRANE SYSTEM|GOLGI APPARATUS BAR domain-containing protein that localizes to both early and late Golgi vesicles; required for adaptation to varying nutrient concentrations, fluid-phase endocytosis, polarization of the actin cytoskeleton, and vacuole biogenesis vacuole organization|endocytosis|establishment or maintenance of actin cytoskeleton polarity molecular_function integral to Golgi membrane|cytoplasm
YEL005C YEL005C VAB2 hom Verified 0.657125541423701 0.255550098542072 no 1246 0.253917240063457 859 NA Protein with a potential role in vacuolar function, as suggested by its ability to bind Vac8p; likely member of BLOC complex involved in endosomal cargo sorting; Vab2p-GFP-fusion localizes to cytoplasm in punctate patter biological_process molecular_function cytoplasm
YJL216C YJL216C IMA5 hom Verified 0.657107910742276 0.255555766341408 no 1247 0.272742058174763 937 NA FT CARBOHYDRATE METABOLISM Alpha-glucosidase; specificity for isomaltose, maltose, and palatinose, but not alpha-methylglucoside; member of the IMA isomaltase family; not required for isomaltose utilization, but Ima5p overexpression allows the ima1 null mutant to grow on isomaltose disaccharide catabolic process oligo-1,6-glucosidase activity cellular_component
YOR118W YOR118W RTC5 hom Verified 0.656163027310797 0.255859617491304 no 1248 0.279398379157255 963 NA Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity biological_process molecular_function cytoplasm
YKL033W-A_p YKL033W-A YKL033W-A hom Uncharacterized 0.655305986661147 0.256135383559548 no 1249 0.30227265087106 1024 NA Putative protein of unknown function; similar to uncharacterized proteins from other fungi biological_process molecular_function cellular_component
YOR252W YOR252W TMA16 hom Verified 0.654698416168711 0.256330972599194 no 1250 0.245407206848361 850 NA FT NUCLEUS Protein of unknown function that associates with ribosomes biological_process molecular_function ribosome|nucleus
YEL008W_d YEL008W YEL008W hom Dubious 0.654317889382895 0.256453511381913 no 1251 0.239679201566012 807 NA Hypothetical protein predicted to be involved in metabolism Unknown Unknown Unknown
YNR042W_d YNR042W YNR042W hom Dubious 0.654036895378772 0.256544017799978 no 1252 0.244102376226602 836 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2 Unknown Unknown Unknown
YPR011C_p YPR011C YPR011C hom Uncharacterized 0.653148883272146 0.256830150300471 no 1253 0.223937783679997 736 NA FT MITOCHONDRION Putative transporter, member of the mitochondrial carrier family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies transport transporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YLR429W YLR429W CRN1 hom Verified 0.652244190890184 0.257121828179386 no 1254 0.242079865111301 833 NA FT CYTOSKELETON ORGANIZATION CYTOSKELETON Coronin, cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity; plays a role in regulation of actin patch assembly microtubule-based process|actin filament organization|actin cortical patch localization|Unknown|negative regulation of Arp2/3 complex-mediated actin nucleation microtubule binding|actin filament binding|protein binding, bridging Arp2/3 protein complex|actin cortical patch
YBR272C YBR272C HSM3 hom Verified 0.652042085056853 0.25718701176072 no 1255 0.245551828936847 845 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE NUCLEUS Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); involved in DNA mismatch repair during slow growth; weak similarity to Msh1p; related to human 19S subunit S5b; structural study suggests Hsm3p is a scaffold protein for Rpt1p-Rpt2p complex formation mismatch repair|proteasome regulatory particle assembly molecular_function cytosol|proteasome regulatory particle, base subcomplex|nucleus|cytoplasm
YGR292W YGR292W MAL12 hom Verified 0.65164569440087 0.25731488142083 no 1256 0.225876035764544 760 NA FT CARBOHYDRATE METABOLISM Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose sucrose catabolic process|maltose catabolic process sucrose alpha-glucosidase activity|maltose alpha-glucosidase activity plasma membrane
YPR052C YPR052C NHP6A hom Verified 0.65141721881459 0.257388599214754 no 1257 0.246098107540564 846 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME High-mobility group (HMG) protein, binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to chromosomes; functionally redundant with Nhp6Bp; homologous to mammalian HMGB1 and HMGB2; NHP6A has a paralog, NHP6B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress mismatch repair|DNA replication-independent nucleosome organization|RNA polymerase II transcriptional preinitiation complex assembly|RNA polymerase III transcriptional preinitiation complex assembly|chromatin remodeling nucleosome binding|sequence-specific DNA binding|DNA binding, bending MutSalpha complex|nucleus
YLR415C_p YLR415C YLR415C hom Uncharacterized 0.651000294492991 0.257523148392041 no 1258 0.259339802508681 894 NA FT MITOCHONDRION Putative protein of unknown function; YLR415C is not an essential gene biological_process molecular_function cellular_component
YJL120W_d YJL120W YJL120W hom Dubious 0.650859156238705 0.257568704588436 no 1259 0.317254886711795 1082 NA FF Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL121C/RPE1; deletion confers sensitivity to GSAO Unknown Unknown Unknown
YDL118W_d YDL118W YDL118W hom Dubious 0.650850606974107 0.257571464229703 no 1260 0.289983342030077 997 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS Dubious open reading frame, unlikely to encode a protein; overlaps almost completely with YDL119C; mutations that would affect both YDL118W and YDL119C confer defective telomere maintenance and are synthetically sick or lethal with alpha-synuclein biological_process molecular_function cellular_component
YEL047C YEL047C FRD1 hom Verified 0.650388888271405 0.257720526519469 no 1261 0.254356314932604 876 NA FT OXIDATION-REDUCTION PROCESS MITOCHONDRION Soluble fumarate reductase; required with isoenzyme Osm1p for anaerobic growth; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to Arxula adeninovorans fumarate reductase; protein abundance increases in response to DNA replication stress; FRD1 has a paralog, OSM1, that arose from the whole genome duplication cellular response to anoxia fumarate reductase (NADH) activity cytosol|mitochondrion|ribosome|plasma membrane
YAL055W YAL055W PEX22 hom Verified 0.650370112726398 0.257726589005457 no 1262 0.27249379269866 929 NA FT PROTEIN LOCALIZATION|SIGNALING|PEROXISOME ORGANIZATION Putative peroxisomal membrane protein required for import of peroxisomal proteins, functionally complements a Pichia pastoris pex22 mutation protein import into peroxisome matrix, receptor recycling|protein targeting to peroxisome protein anchor integral to peroxisomal membrane
YMR118C_p YMR118C SHH3 hom Uncharacterized 0.650336165234108 0.257737550590049 no 1263 0.238258298467778 798 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Putative mitochondrial inner membrane protein of unknown function; although similar to Sdh3p, Shh3p is not a stoichiometric subunit of either succinate dehydrogenase or of the TIM22 translocase biological_process molecular_function integral to membrane
YMR020W YMR020W FMS1 hom Verified 0.649842476952608 0.257896989000637 no 1264 0.221715260856555 773 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis pantothenate biosynthetic process|polyamine catabolic process polyamine oxidase activity cytoplasm
YDR154C_d YDR154C YDR154C hom Dubious 0.649711251106784 0.257939377468148 no 1265 0.227256300115779 762 NA Dubious open reading frame, null mutant exhibits synthetic phenotype with alpha-synuclein Unknown Unknown Unknown
YIR014W_p YIR014W YIR014W hom Uncharacterized 0.649562457744349 0.257987444953055 no 1266 0.240629235834933 833 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; YIR014W is a non-essential gene biological_process molecular_function fungal-type vacuole
YHR006W YHR006W STP2 hom Verified 0.649521772719141 0.258000589001688 no 1267 0.232303483238935 793 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS|PLASMA MEMBRANE Transcription factor; activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes; STP2 has a paralog, STP1, that arose from the whole genome duplication positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus|cytoplasm
YNR055C YNR055C HOL1 hom Verified 0.648950606696794 0.258185151392609 no 1268 0.246013433764823 855 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION|PLASMA MEMBRANE Putative transporter in the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; mutations in membrane-spanning domains permit cation and histidinol uptake organic alcohol transport|cation transport alcohol transmembrane transporter activity|inorganic cation transmembrane transporter activity mitochondrion|integral to membrane|plasma membrane
YLR329W YLR329W REC102 hom Verified 0.648743511442077 0.258252087535107 no 1269 0.274495552677381 946 NA FT CELL CYCLE NUCLEUS|CHROMOSOME Protein involved in early stages of meiotic recombination; required for chromosome synapsis; forms a complex with Rec104p and Spo11p necessary during the initiation of recombination meiotic DNA double-strand break formation|reciprocal meiotic recombination molecular_function condensed nuclear chromosome|nucleus
YDL128W YDL128W VCX1 hom Verified 0.648641751459592 0.258284981109417 no 1270 0.225892931986462 767 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Vacuolar membrane antiporter with Ca2+/H+ and K+/H+ exchange activity, involved in control of cytosolic Ca2+ and K+ concentrations; has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter manganese ion transport|cellular calcium ion homeostasis|calcium ion transport|transmembrane transport potassium:hydrogen antiporter activity|calcium:hydrogen antiporter activity fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YNL013C_d YNL013C YNL013C hom Dubious 0.648120334776057 0.258453561371674 no 1271 0.232227735132854 765 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF HEF3/YNL014W Unknown Unknown Unknown
YOR193W YOR193W PEX27 hom Verified 0.647896559800299 0.25852592797885 no 1272 0.25461832417015 847 NA FT PEROXISOME ORGANIZATION Peripheral peroxisomal membrane protein involved in controlling peroxisome size and number, interacts with homologous protein Pex25p peroxisome organization molecular_function peroxisomal membrane
YER044C-A YER044C-A MEI4 hom Verified 0.647813348334283 0.258552840417871 no 1273 0.23989795548616 834 NA FT CELL CYCLE NUCLEUS|CHROMOSOME Meiosis-specific protein involved in double-strand break formation during meiotic recombination; required for chromosome synapsis and production of viable spores meiotic DNA double-strand break formation molecular_function condensed nuclear chromosome
YNR032W YNR032W PPG1 hom Verified 0.647774896800118 0.25856527698941 no 1274 0.258272038434371 866 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Putative serine/threonine protein phosphatase of the type 2A-like phosphatase family, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases glycogen metabolic process|protein dephosphorylation protein serine/threonine phosphatase activity nucleus|cytoplasm
YER144C YER144C UBP5 hom Verified 0.647161174978107 0.258763818022743 no 1275 0.259677744148328 895 NA FT PROTEOLYSIS SITE OF POLARIZED GROWTH Putative ubiquitin-specific protease, closest paralog of Doa4p but has no functional overlap; concentrates at the bud neck protein deubiquitination ubiquitin-specific protease activity incipient cellular bud site|cellular bud neck
YMR294W YMR294W JNM1 hom Verified 0.644631612798808 0.259582971736293 no 1276 0.292532370124926 1019 NA FF|FT CELL CYCLE|CYTOSKELETON ORGANIZATION CYTOSKELETON Component of the yeast dynactin complex, consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B nuclear migration|establishment of mitotic spindle orientation structural constituent of cytoskeleton dynactin complex|cell cortex|spindle pole body|astral microtubule
YBR035C YBR035C PDX3 hom Verified 0.643740405582085 0.259871891959898 no 1277 0.253585916174966 882 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism fatty acid metabolic process pyridoxamine-phosphate oxidase activity cellular_component
YEL059W_d YEL059W HHY1 hom Dubious 0.643737210055589 0.259872928215157 no 1278 0.245596007705778 814 NA Dubious open reading frame unlikely to encode a functional protein; mutant is hypersensitive to hygromycin B indicative of defects in vacuolar trafficking Unknown Unknown Unknown
YOR068C YOR068C VAM10 hom Verified 0.643672652974665 0.259893863442425 no 1279 0.26655515136975 930 NA FT MEMBRANE ORGANIZATION Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering vacuole fusion, non-autophagic molecular_function fungal-type vacuole membrane
YPR037C YPR037C ERV2 hom Verified 0.642971213443722 0.260121389460286 no 1280 0.254455566776364 865 NA FT OXIDATION-REDUCTION PROCESS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen, involved in disulfide bond formation within the ER protein thiol-disulfide exchange thiol oxidase activity integral to endoplasmic reticulum membrane
YJL188C_d YJL188C BUD19 hom Dubious 0.642630797616604 0.260231847176483 no 1281 0.228573689067326 788 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay Unknown Unknown Unknown
YML083C YML083C YML083C hom Verified 0.642166056518673 0.260382684822108 no 1282 0.238459102539647 814 NA Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions biological_process molecular_function cellular_component
YDL009C_p YDL009C YDL009C hom Uncharacterized 0.64137528011007 0.260639444852459 no 1283 0.257843396738363 880 NA Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the verified ORF YDL010W; YDL009C is not an essential gene biological_process molecular_function cellular_component
YLR204W YLR204W QRI5 hom Verified 0.640916619954748 0.260788428556408 no 1284 0.306460133101873 1059 NA FF|FT RNA PROCESSING MITOCHONDRION Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA mRNA processing molecular_function mitochondrion|integral to mitochondrial inner membrane
YEL044W YEL044W IES6 hom Verified 0.640351825260555 0.260971947454188 no 1285 0.284783008459546 994 NA FT NUCLEUS Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions; human ortholog INO80C is a member of the human INO80 complex; implicated in DNA repair based on genetic interactions with RAD52 epistasis genes biological_process molecular_function nucleus
YBR101C YBR101C FES1 hom Verified 0.639484849165231 0.261253783390029 no 1286 0.259934021644807 932 NA FT TRANSLATION RIBOSOME Hsp70 (Ssa1p) nucleotide exchange factor; cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum; protein abundance increases in response to DNA replication stress cytoplasmic translation adenyl-nucleotide exchange factor activity cytosol|cytosolic ribosome
YER041W YER041W YEN1 hom Verified 0.639417481316316 0.261275689825601 no 1287 0.255605605864411 931 NA FT RESPONSE TO DNA DAMAGE NUCLEUS Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p DNA repair|response to DNA damage stimulus single-stranded DNA specific endodeoxyribonuclease activity|crossover junction endodeoxyribonuclease activity nucleus|cytoplasm
YHL011C YHL011C PRS3 hom Verified 0.63863295009043 0.261530870344869 no 1288 0.279136368620323 963 NA FF|FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes fungal-type cell wall organization|5-phosphoribose 1-diphosphate biosynthetic process|regulation of cell size ribose phosphate diphosphokinase activity cytoplasm
YGR269W_d YGR269W YGR269W hom Dubious 0.638396031499636 0.261607956806583 no 1289 0.280275173009163 954 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF HUA1/YGR268C Unknown Unknown Unknown
YIL153W YIL153W RRD1 hom Verified 0.638124458238285 0.261696333239407 no 1290 0.279478558451684 969 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RESPONSE TO DNA DAMAGE|CYTOSKELETON ORGANIZATION NUCLEUS|CHROMOSOME Peptidyl-prolyl cis/trans-isomerase; activator of the phosphotyrosyl phosphatase activity of PP2A; involved in G1 phase progression, microtubule dynamics, bud morphogenesis and DNA repair; required for rapid reduction of Sgs1p levels in response to rapamycin; subunit of the Tap42p-Sit4p-Rrd1p complex; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress DNA repair|mitotic spindle organization in nucleus|G1/S transition of mitotic cell cycle|response to osmotic stress|regulation of transcription from RNA polymerase II promoter in response to stress peptidyl-prolyl cis-trans isomerase activity|protein phosphatase type 2A regulator activity nuclear chromatin|nucleus|cytoplasm
YBR018C YBR018C GAL7 hom Verified 0.637414673452281 0.261927386500296 no 1291 0.261482991575996 914 NA FT CARBOHYDRATE METABOLISM Galactose-1-phosphate uridyl transferase, synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism galactose catabolic process via UDP-galactose UDP-glucose:hexose-1-phosphate uridylyltransferase activity cytoplasm
YHR050W-A_p YHR050W-A YHR050W-A hom Uncharacterized 0.63673736011713 0.262147966959919 no 1292 0.263391797450893 904 NA Protein of unknown function; identified by expression profiling and mass spectrometry biological_process molecular_function cellular_component
YHL014C YHL014C YLF2 hom Verified 0.636085261140982 0.262360425769523 no 1293 0.262157812114181 919 NA FT MITOCHONDRION Protein of unknown function, has weak similarity to E. coli GTP-binding protein gtp1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process GTP binding mitochondrion
YDR528W YDR528W HLR1 hom Verified 0.635708385133635 0.26248325503663 no 1294 0.238694888037397 783 NA FT CELL WALL ORG/BIOGENESIS Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A;
HLR1 has a paralog, LRE1, that arose from the whole genome duplication fungal-type cell wall organization molecular_function cytoplasm
YDL026W_d YDL026W YDL026W hom Dubious 0.635647354253772 0.262503148640232 no 1295 0.273565303685534 949 NA Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR213W YDR213W UPC2 hom Verified 0.63534982601211 0.262600141889995 no 1296 0.27361998037765 933 NA FT TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM NUCLEUS Sterol regulatory element binding protein; induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; relocates from intracellular membranes to perinuclear foci on sterol depletion; UPC2 has a paralog, ECM22, that arose from the whole genome duplication cellular response to hypoxia|positive regulation of ergosterol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus|membrane|cytoplasm|perinuclear region of cytoplasm
YIL006W YIL006W YIA6 hom Verified 0.635277201810654 0.262623819930457 no 1297 0.275518017010107 954 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Mitochondrial NAD+ transporter, involved in the transport of NAD+ into the mitochondria (see also YEA6); member of the mitochondrial carrier subfamily; disputed role as a pyruvate transporter; has putative mouse and human orthologs transport|mitochondrial pyruvate transport|NAD transmembrane transport pyruvate secondary active transmembrane transporter activity|transporter activity|NAD transporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YBL071W-A YBL071W-A KTI11 hom Verified 0.634840388197597 0.262766259553911 no 1298 0.314405130649431 1074 NA FT RNA PROCESSING NUCLEUS Zn-ribbon protein that co-purifies with Dph1 and Dph2 in a complex required for synthesis of diphthamide on translation factor eEF2 and with Elongator subunits Iki3p, Elp2p, and Elp3p involved in modification of wobble nucleosides in tRNAs peptidyl-diphthamide biosynthetic process from peptidyl-histidine|tRNA wobble uridine modification electron carrier activity|iron ion binding|zinc ion binding nucleus|cytoplasm
YLR091W YLR091W GEP5 hom Verified 0.634339321997305 0.262929699814861 no 1299 0.287553547705247 967 NA FT MITOCHONDRION ORGANIZATION MITOCHONDRION Protein of unknown function, required for mitochondrial genome maintenance; detected in highly purified mitochondria in high-throughput studies; null mutant has decreased levels of cardiolipin and phosphatidylethanolamine mitochondrial genome maintenance molecular_function mitochondrion
YGL101W_p YGL101W YGL101W hom Uncharacterized 0.634079242198956 0.263014554419569 no 1300 0.263738245744296 863 NA FT NUCLEUS Putative protein of unknown function; non-essential gene with similarity to YBR242W; interacts with the DNA helicase Hpr5p biological_process molecular_function nucleus|cytoplasm
YFR049W YFR049W YMR31 hom Verified 0.633905927160586 0.263071108600705 no 1301 0.286851585239767 990 NA FT TRANSLATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit, has similarity to human mitochondrial ribosomal protein MRP-S36 cytoplasmic translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YFL007W YFL007W BLM10 hom Verified 0.63384764861097 0.263090126786531 no 1302 0.266876929785799 923 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS NUCLEUS Proteasome activator; binds the core proteasome and stimulates proteasome-mediated protein degradation by inducing gate opening; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200 proteasome assembly|regulation of proteasomal protein catabolic process proteasome binding|peptidase activator activity proteasome core complex|proteasome complex|integral to membrane|nucleus
YFL016C YFL016C MDJ1 hom Verified 0.632411987334167 0.263558851473296 no 1303 0.331819836477979 1086 NA FT PROTEOLYSIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones protein refolding|response to heat|misfolded or incompletely synthesized protein catabolic process|mitochondrial genome maintenance|'de novo' protein folding unfolded protein binding|ATPase activator activity extrinsic to mitochondrial inner membrane|mitochondrion|mitochondrial matrix
YDR179W-A_p YDR179W-A YDR179W-A hom Uncharacterized 0.632181940649756 0.263633998308643 no 1304 0.266591136190459 867 NA Putative protein of unknown function biological_process molecular_function cellular_component
YPR083W YPR083W MDM36 hom Verified 0.631517656261495 0.263851054165481 no 1305 0.272098244402672 897 NA FT MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial protein required for normal mitochondrial morphology and inheritance; proposed involvement in the formation of Dnm1p and Num1p-containing cortical anchor complexes that promote mitochondrial fission mitochondrial fission|mitochondrion organization molecular_function mitochondrion|cytoplasm
YDR252W YDR252W BTT1 hom Verified 0.631086826496234 0.263991877088788 no 1306 0.26038845649786 857 NA FT PROTEIN LOCALIZATION NUCLEUS Beta3 subunit of the heterotrimeric nascent polypeptide-associated complex which binds ribosomes via its beta-subunits in close proximity to nascent polypeptides; interacts with Caf130p of the CCR4-NOT complex; similar to human BTF3 'de novo' cotranslational protein folding unfolded protein binding nascent polypeptide-associated complex|CCR4-NOT complex
YDR206W YDR206W EBS1 hom Verified 0.631034909380993 0.264008849532426 no 1307 0.27128214486981 890 NA FT TRANSLATION NUCLEUS|CHROMOSOME Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors negative regulation of translation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay molecular_function cytoplasmic mRNA processing body|cytoplasm
YJR104C YJR104C SOD1 hom Verified 0.630843685627118 0.264071368093883 no 1308 0.358551350362732 1228 NA FF|FT ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS NUCLEUS|MITOCHONDRION Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid cellular copper ion homeostasis|fungal-type cell wall organization|superoxide metabolic process|cellular zinc ion homeostasis|positive regulation of sequence-specific DNA binding transcription factor activity|age-dependent response to reactive oxygen species involved in chronological cell aging superoxide dismutase activity cytosol|mitochondrion|nucleus|mitochondrial intermembrane space
YJL128C YJL128C PBS2 hom Verified 0.630456503565042 0.264197976223062 no 1309 0.298843502480787 1038 NA FF|FT PROTEIN LOCALIZATION|SIGNALING|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION SITE OF POLARIZED GROWTH MAP kinase kinase of the HOG signaling pathway; activated under severe osmotic stress; mitophagy-specific regulator; plays a role in regulating Ty1 transposition activation of MAPK activity involved in osmosensory signaling pathway|actin filament organization|MAPK import into nucleus involved in osmosensory signaling pathway|protein phosphorylation|hyperosmotic response|osmosensory signaling pathway|cellular response to heat MAP-kinase scaffold activity|MAP kinase kinase activity|protein kinase activity cellular bud neck|cytoplasm|cellular bud tip
YJL198W YJL198W PHO90 hom Verified 0.630341038410175 0.264235739191679 no 1310 0.266763848198183 900 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth; PHO90 has a paralog, PHO87, that arose from the whole genome duplication phosphate ion transport phosphate ion transmembrane transporter activity integral to membrane|membrane
YGR215W YGR215W RSM27 hom Verified 0.630009793826745 0.264344088241862 no 1311 0.270313116630542 924 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YLL027W YLL027W ISA1 hom Verified 0.629759441779297 0.264425992605248 no 1312 0.284821573108219 999 NA FT KETONE METABOLISM|COFACTOR METABOLISM MITOCHONDRION Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa2p and possibly Iba57p; isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources; functional ortholog of bacterial A-type ISC proteins biotin biosynthetic process|iron-sulfur cluster assembly iron-sulfur cluster binding|iron ion binding mitochondrial matrix
YKR048C YKR048C NAP1 hom Verified 0.628704997604444 0.26477110284595 no 1313 0.274599448673486 959 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION NUCLEUS|SITE OF POLARIZED GROWTH|CHROMOSOME Protein that interacts with mitotic cyclin Clb2p; required for the regulation of microtubule dynamics during mitosis; controls bud morphogenesis; involved in the transport of H2A and H2B histones to the nucleus; phosphorylated by CK2; protein abundance increases in response to DNA replication stress budding cell bud growth|M phase of mitotic cell cycle|nucleosome disassembly|protein import into nucleus|nucleosome assembly cyclin binding|histone binding nucleus|nuclear nucleosome|cytoplasm
YOR052C YOR052C YOR052C hom Verified 0.628460836434095 0.264851047275683 no 1314 0.264321370861516 893 NA FT NUCLEUS Nuclear protein of unknown function; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner and by weak acid; transcriptionally regulated by Rpn4p along with proteasome subunit genes; putative ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus
YOR216C YOR216C RUD3 hom Verified 0.628428808500873 0.264861534926523 no 1315 0.265154113774375 910 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT GOLGI APPARATUS Golgi matrix protein involved in the structural organization of the cis-Golgi; interacts genetically with COG3 and USO1 ER to Golgi vesicle-mediated transport molecular_function Golgi apparatus
YDL081C YDL081C RPP1A hom Verified 0.628130424355803 0.264959251927906 no 1316 0.260537494973953 881 NA FT TRANSLATION RIBOSOME Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component cytoplasmic translation|translational elongation structural constituent of ribosome cytosolic large ribosomal subunit
YLR404W YLR404W FLD1 hom Verified 0.627681665690867 0.265106249153 no 1317 0.267400309881113 888 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Seipin protein involved in lipid droplet morphology, number, and size; proposed to be involved in lipid metabolism; related to the human BSCL2 which is associated with lipodystrophy lipid particle organization molecular_function integral to membrane|endoplasmic reticulum|cortical endoplasmic reticulum
YBR199W YBR199W KTR4 hom Verified 0.62756164267097 0.265145571404434 no 1318 0.219902157467609 746 NA FT CARBOHYDRATE METABOLISM GOLGI APPARATUS Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family protein N-linked glycosylation mannosyltransferase activity Golgi apparatus
YCR036W YCR036W RBK1 hom Verified 0.62743479077949 0.265187134167902 no 1319 0.307551232998376 1035 NA FT CARBOHYDRATE METABOLISM NUCLEUS Putative ribokinase D-ribose metabolic process ribokinase activity|ATP binding nucleus|cytoplasm
YJR070C YJR070C LIA1 hom Verified 0.627259388609009 0.265244609780832 no 1320 0.273252358060889 932 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CYTOSKELETON ORGANIZATION NUCLEUS Deoxyhypusine hydroxylase; HEAT-repeat containing metalloenzyme that catalyzes hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning; protein abundance increases in response to DNA replication stress microtubule cytoskeleton organization|peptidyl-lysine modification to hypusine deoxyhypusine monooxygenase activity nucleus|cytoplasm
YER103W YER103W SSA4 hom Verified 0.627168464415563 0.265274406221093 no 1321 0.2512071131366 873 NA FT PROTEIN LOCALIZATION NUCLEUS Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation; SSA4 has a paralog, SSA3, that arose from the whole genome duplication protein folding|SRP-dependent cotranslational protein targeting to membrane, translocation|response to stress unfolded protein binding|ATPase activity nucleus|cytoplasm
YLR416C_d YLR416C YLR416C hom Dubious 0.626845331932921 0.265380312552882 no 1322 0.257155757214649 884 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGL248W YGL248W PDE1 hom Verified 0.62623067375766 0.265581825336859 no 1323 0.25224671080504 859 NA FT SIGNALING|NUCLEOTIDE METABOLISM Low-affinity cyclic AMP phosphodiesterase, controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation cAMP-mediated signaling 3',5'-cyclic-AMP phosphodiesterase activity cellular_component
YPL002C YPL002C SNF8 hom Verified 0.625921122669781 0.265683339577808 no 1324 0.280044908923389 968 NA FF|FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression negative regulation of transcription from RNA polymerase II promoter by glucose|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein targeting to vacuole molecular_function ESCRT II complex
YDR403W YDR403W DIT1 hom Verified 0.62590231452198 0.265689508159234 no 1325 0.25313886091977 842 NA FT CELL WALL ORG/BIOGENESIS Sporulation-specific enzyme required for spore wall maturation, involved in the production of a soluble LL-dityrosine-containing precursor of the spore wall; transcripts accumulate at the time of prospore enclosure ascospore wall assembly catalytic activity cellular_component
YDR130C YDR130C FIN1 hom Verified 0.625199845717929 0.265919951580296 no 1326 0.270434459109217 906 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME|CYTOSKELETON KINETOCHORE Spindle pole body-related intermediate filament protein; forms cell cycle-specific filaments between spindle pole bodies in dividing cells; localizes to poles and microtubules of spindle during anaphase and contributes to spindle stability; involved in Glc7p localization and regulation; relative distribution to the nucleus increases upon DNA replication stress intermediate filament cytoskeleton organization|mitotic cell cycle spindle checkpoint|mitotic spindle stabilization|mitotic sister chromatid segregation microtubule binding|structural constituent of cytoskeleton spindle microtubule|condensed nuclear chromosome kinetochore|intermediate filament|nucleus|spindle pole body|astral microtubule|spindle
YNL334C YNL334C SNO2 hom Verified 0.625173481397676 0.265928602311721 no 1327 0.267783133039582 929 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Protein of unknown function, nearly identical to Sno3p; expression is induced before the diauxic shift and also in the absence of thiamin pyridoxine metabolic process|thiamine biosynthetic process molecular_function cellular_component
YNL074C YNL074C MLF3 hom Verified 0.624497010274364 0.266150616585083 no 1328 0.253951276082346 897 NA Serine-rich protein of unknown function, predicted to be palmitoylated; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide response to drug molecular_function cytoplasm
YDR080W YDR080W VPS41 hom Verified 0.624437463328088 0.266170164073653 no 1329 0.267512527266916 928 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|VACUOLAR PROTEIN PROCESSING Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport regulation of SNARE complex assembly|regulation of vacuole fusion, non-autophagic|piecemeal microautophagy of nucleus|vacuole organization|vesicle-mediated transport|protein transport|vacuole fusion, non-autophagic|vacuolar protein processing Rab guanyl-nucleotide exchange factor activity|phosphatidylinositol binding endosome|fungal-type vacuole membrane|HOPS complex
YOR037W YOR037W CYC2 hom Verified 0.624342733392369 0.266201262587457 no 1330 0.22618050361072 770 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p) cytochrome c-heme linkage|mitochondrial membrane organization oxidoreductase activity extrinsic to mitochondrial inner membrane|mitochondrion
YMR304C-A_d YMR304C-A YMR304C-A hom Dubious 0.624208851049511 0.266245217425991 no 1331 0.263264467485838 901 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SCW10 Unknown Unknown Unknown
YLR366W_d YLR366W YLR366W hom Dubious 0.623351354530182 0.266526828728351 no 1332 0.26317310873766 878 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR364C-A Unknown Unknown Unknown
YEL038W YEL038W UTR4 hom Verified 0.623065277954591 0.266620812928422 no 1333 0.22632108748774 765 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Protein with sequence similarity to 2,3-diketo-5-methylthiopentyl-1-phosphate enolase-phosphatases, involved in methionine salvage; found in both the cytoplasm and nucleus L-methionine salvage from methylthioadenosine acireductone synthase activity nucleus|cytoplasm
YNL327W YNL327W EGT2 hom Verified 0.622372089095771 0.266848614434124 no 1334 0.271884014796654 912 NA FT CELL CYCLE|CELL DIVISION Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis, expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner cytokinesis cellulase activity fungal-type cell wall|cellular bud|cell septum
YDR330W YDR330W UBX5 hom Verified 0.621932591321334 0.266993096783134 no 1335 0.242331424952597 809 NA FT PROTEOLYSIS NUCLEUS UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p proteasomal ubiquitin-dependent protein catabolic process molecular_function nucleus|cytoplasm
YIL005W YIL005W EPS1 hom Verified 0.621730799066104 0.267059448050772 no 1336 0.259717976426173 902 NA FT PROTEIN LOCALIZATION|PROTEOLYSIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM ER protein with chaperone and co-chaperone activity, involved in retention of resident ER proteins; has a role in recognizing proteins targeted for ER-associated degradation (ERAD), member of the protein disulfide isomerase family protein retention in ER lumen|ER-associated protein catabolic process unfolded protein binding|protein disulfide isomerase activity|chaperone binding endoplasmic reticulum membrane
YCL012C YCL012C YCL012C hom Verified 0.621684983801636 0.267074513717623 no 1337 0.249718624291358 839 NA Putative protein of unknown function; orthologs are present in S. bayanus, S. paradoxus and Ashbya gossypii; YCL012C is not an essential gene biological_process molecular_function cellular_component
YER177W YER177W BMH1 hom Verified 0.620612054089874 0.267427453315072 no 1338 0.266102846398899 932 NA FT CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS 14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress glycogen metabolic process|pseudohyphal growth|signal transduction involved in filamentous growth|ascospore formation|fungal-type cell wall chitin biosynthetic process|Ras protein signal transduction|DNA damage checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle DNA replication origin binding|phosphoserine binding plasma membrane|nucleus
YPR029C YPR029C APL4 hom Verified 0.620451480166135 0.267480294243481 no 1339 0.244963689254394 842 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport Golgi to vacuole transport|vesicle-mediated transport clathrin binding AP-1 adaptor complex
YGR062C YGR062C COX18 hom Verified 0.620311626093925 0.267526321067998 no 1340 0.265456653351332 921 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial integral inner membrane protein required for membrane insertion of C-terminus of Cox2p; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC protein insertion into mitochondrial membrane from inner side membrane insertase activity integral to membrane|integral to mitochondrial inner membrane
YMR077C YMR077C VPS20 hom Verified 0.620103554810095 0.267594805980788 no 1341 0.301871270209007 1029 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT Myristoylated subunit of ESCRTIII, the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranes intralumenal vesicle formation|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|late endosome to vacuole transport protein binding ESCRT III complex|cytoplasm
YCL038C YCL038C ATG22 hom Verified 0.620074715150955 0.267604299009339 no 1342 0.259873202513605 893 NA FT PROTEIN LOCALIZATION|VACUOLAR TRANSPORT Vacuolar integral membrane protein required for efflux of amino acids during autophagic body breakdown in the vacuole; null mutation causes a gradual loss of viability during starvation amino acid export from vacuole molecular_function integral to fungal-type vacuolar membrane|integral to membrane
YMR251W YMR251W GTO3 hom Verified 0.619918104088354 0.267655852973954 no 1343 0.279530173798304 984 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Omega class glutathione transferase; putative cytosolic localization glutathione metabolic process glutathione transferase activity cytoplasm
YBR062C_p YBR062C YBR062C hom Uncharacterized 0.619834132573045 0.267683497172915 no 1344 0.252182801961838 848 NA Protein of unknown function that interacts with Msb2p; may play a role in activation of the filamentous growth pathway. biological_process molecular_function cellular_component
YPR117W_p YPR117W YPR117W hom Uncharacterized 0.619339510207257 0.267846360622957 no 1345 0.266423816437013 896 NA Putative protein of unknown function biological_process molecular_function cellular_component
YMR293C YMR293C HER2 hom Verified 0.619171389149344 0.267901728916589 no 1346 0.27385872394331 976 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION MITOCHONDRION Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase endoplasmic reticulum organization|glutaminyl-tRNAGln biosynthesis via transamidation glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity mitochondrion|glutamyl-tRNA(Gln) amidotransferase complex
YJL107C_p YJL107C YJL107C hom Uncharacterized 0.619005847138127 0.26795625346961 no 1347 0.251680030364471 878 NA Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi biological_process molecular_function cellular_component
YDR222W_p YDR222W YDR222W hom Uncharacterized 0.618566493329371 0.268100990473687 no 1348 0.299032500463813 1020 NA FT RESPONSE TO OXIDATIVE STRESS Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern biological_process molecular_function cytoplasm
YDL094C_d YDL094C YDL094C hom Dubious 0.618458796125417 0.268136475334269 no 1349 0.244579837991507 862 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verfied gene PMT5/YDL093W; YDL094C is not essential Unknown Unknown Unknown
YKL205W YKL205W LOS1 hom Verified 0.618370998008002 0.268165405447496 no 1350 0.277030763618987 935 NA FT RNA PROCESSING|RNA LOCALIZATION NUCLEUS|MITOCHONDRION Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm tRNA re-export from nucleus|tRNA splicing, via endonucleolytic cleavage and ligation|tRNA export from nucleus tRNA binding|Ran GTPase binding mitochondrion|integral to membrane|nuclear matrix|cytoplasm
YLR001C_p YLR001C YLR001C hom Uncharacterized 0.617632887276413 0.26840868035448 no 1351 0.249673807987645 875 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; predicted to be palmitoylated biological_process molecular_function mitochondrion|fungal-type vacuole membrane
YCR092C YCR092C MSH3 hom Verified 0.617190710613343 0.268554471092081 no 1352 0.273582825050931 959 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Mismatch repair protein, forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability mismatch repair|mitotic recombination|meiotic mismatch repair|removal of nonhomologous ends|DNA recombination DNA insertion or deletion binding|mismatched DNA binding|double-strand/single-strand DNA junction binding|loop DNA binding|Y-form DNA binding MutSbeta complex|nucleus|cytoplasm
YDL073W_p YDL073W YDL073W hom Uncharacterized 0.617108968403416 0.268581426798563 no 1353 0.299211673218419 1065 NA Putative protein of unknown function; YDL073W is not an essential gene biological_process molecular_function cellular_component
YBR081C YBR081C SPT7 hom Verified 0.616518971008466 0.268776027513329 no 1354 0.325300672077954 1105 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION NUCLEUS|MITOCHONDRION HISTONE ACETYLTRANSFERASE Subunit of the SAGA transcriptional regulatory complex, involved in proper assembly of the complex; also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex conjugation with cellular fusion|histone acetylation|protein complex assembly|chromatin modification structural molecule activity SLIK (SAGA-like) complex|mitochondrion|SAGA complex
YNL294C YNL294C RIM21 hom Verified 0.615788787499028 0.269016964284046 no 1355 0.289859556858515 1027 NA FF|FT ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS PLASMA MEMBRANE pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH fungal-type cell wall biogenesis|ascospore formation|invasive growth in response to glucose limitation molecular_function integral to membrane
YIR031C YIR031C DAL7 hom Verified 0.615706534278072 0.269044111959528 no 1356 0.272061853266934 930 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM Malate synthase, role in allantoin degradation unknown; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation allantoin catabolic process malate synthase activity cellular_component
YFR035C_p YFR035C YFR035C hom Uncharacterized 0.615450358439539 0.269128671603505 no 1357 0.256314702196886 876 NA Putative protein of unknown function, deletion mutant exhibits synthetic phenotype with alpha-synuclein biological_process molecular_function cellular_component
YBR255W YBR255W MTC4 hom Verified 0.615217667453875 0.269205490819966 no 1358 0.291145904025625 984 NA Protein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; mtc4 is synthetically sick with cdc13-1 biological_process molecular_function cytoplasm
YJR119C YJR119C JHD2 hom Verified 0.615177069624728 0.269218894672411 no 1359 0.237268981980412 820 NA FT CHROMATIN ORGANIZATION|OXIDATION-REDUCTION PROCESS NUCLEUS JmjC domain family histone demethylase specific for H3-K4 (histone H3 Lys4); removes methyl groups specifically added by Set1p methyltransferase; protein levels regulated by Not4p (E3 ubiquitin ligase) polyubiquitin-mediated degradation histone demethylation histone demethylase activity (H3-K4 specific) nucleus|cytoplasm
YDR321W YDR321W ASP1 hom Verified 0.614903905245731 0.269309091819615 no 1360 0.26232182346185 902 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Cytosolic L-asparaginase, involved in asparagine catabolism; catalyzes hydrolysis of L-asparagine to aspartic acid and ammonia, has an important role in therapy of acute lymphoblastic leukemia; synthesized constitutively asparagine catabolic process asparaginase activity intracellular
YBL066C YBL066C SEF1 hom Verified 0.614675056391421 0.26938466792549 no 1361 0.239125773385027 822 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Putative transcription factor, has homolog in Kluyveromyces lactis biological_process molecular_function cellular_component
YER024W YER024W YAT2 hom Verified 0.61460878428222 0.26940655591921 no 1362 0.268713607018941 876 NA FT KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane carnitine metabolic process|alcohol metabolic process carnitine O-acetyltransferase activity cytosol|cytoplasm
YGL152C_d YGL152C YGL152C hom Dubious 0.61427148275099 0.269517971859378 no 1363 0.283823354443689 956 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PEX14/YGL153W Unknown Unknown Unknown
YLR011W YLR011W LOT6 hom Verified 0.614212242711809 0.269537542149077 no 1364 0.237814507955942 792 NA FT PROTEIN LOCALIZATION|OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS NUCLEUS FMN-dependent NAD(P)H:quinone reductase, may be involved in quinone detoxification; expression elevated at low temperature; sequesters the Cin5p transcription factor in the cytoplasm in complex with the proteasome under reducing conditions cellular response to oxidative stress|cytoplasmic sequestering of transcription factor NAD(P)H dehydrogenase (quinone) activity|transcription factor binding cytosol|nucleus|cytoplasm
YOR120W YOR120W GCY1 hom Verified 0.613986985069019 0.269611963816166 no 1365 0.303039577132015 998 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS NUCLEUS Glycerol dehydrogenase;involved in an alternative pathway for glycerol catabolism used under microaerobic conditions; also has mRNA binding activity; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress; GCY1 has a paralog, YPR1, that arose from the whole genome duplication cellular response to oxidative stress|arabinose catabolic process|D-xylose catabolic process oxidoreductase activity|mRNA binding|alditol:NADP+ 1-oxidoreductase activity|aldo-keto reductase (NADP) activity nucleus|cytoplasm
YMR221C_p YMR221C YMR221C hom Uncharacterized 0.613831939296654 0.269663194540217 no 1366 0.263676427898838 931 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; physical interaction with Atg27p suggests a possible role in autophagy biological_process molecular_function mitochondrion|integral to membrane|fungal-type vacuole
YAL054C YAL054C ACS1 hom Verified 0.613502694577796 0.269772000811869 no 1367 0.252666317670507 843 NA FT KETONE METABOLISM|CHROMATIN ORGANIZATION|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetylation; expressed during growth on nonfermentable carbon sources and under aerobic conditions acetate fermentation|histone acetylation|acetyl-CoA biosynthetic process acetate-CoA ligase activity|acid-ammonia (or amide) ligase activity cytosol|mitochondrion|integral to membrane
YBR186W YBR186W PCH2 hom Verified 0.613118983005562 0.269898834606653 no 1368 0.231279162286525 766 NA FT CELL CYCLE NUCLEUS|CHROMOSOME Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA; required for meiotic double-stranded break formation meiotic recombination checkpoint|meiotic DNA double-strand break formation|reciprocal meiotic recombination ATPase activity nucleolus
YEL043W YEL043W YEL043W hom Verified 0.613107573420461 0.269902606440524 no 1369 0.267749756970498 941 NA FT ENDOPLASMIC RETICULUM Predicted cytoskeleton protein involved in intracellular signalling based on quantitative analysis of protein-protein interaction maps; may interact with ribosomes, based on co-purification studies; contains fibronectin type III domain fold biological_process molecular_function ribosome|endoplasmic reticulum
YKL032C YKL032C IXR1 hom Verified 0.612902947841006 0.269970256998895 no 1370 0.312845498131361 1069 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Protein that binds DNA containing intrastrand cross-links formed by cisplatin, contains two HMG (high mobility group box) domains, which confer the ability to bend cisplatin-modified DNA; mediates aerobic transcriptional repression of COX5b DNA repair|cellular response to hypoxia|negative regulation of transcription from RNA polymerase II promoter damaged DNA binding|sequence-specific DNA binding nuclear chromatin
YDL171C YDL171C GLT1 hom Verified 0.61270260944876 0.270036498405248 no 1371 0.254954745308015 873 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION NAD(+)-dependent glutamate synthase (GOGAT), synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source glutamate biosynthetic process|ammonia assimilation cycle glutamate synthase (NADH) activity mitochondrion
YKR031C YKR031C SPO14 hom Verified 0.612395651991652 0.270138008922093 no 1372 0.266372726924903 917 NA FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|LIPID METABOLISM NUCLEUS Phospholipase D; catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions phospholipid metabolic process|exocytosis|cell morphogenesis involved in conjugation with cellular fusion|ascospore-type prospore assembly phospholipase D activity|phosphatidylinositol-3-phosphate binding endosome|nucleus|prospore membrane
YDL080C YDL080C THI3 hom Verified 0.612282620471228 0.270175393137942 no 1373 0.259119089833023 872 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Probable alpha-ketoisocaproate decarboxylase, may have a role in catabolism of amino acids to long-chain and complex alcohols; required for expression of enzymes involved in thiamine biosynthesis regulation of thiamine biosynthetic process|branched-chain amino acid catabolic process to alcohol via Ehrlich pathway|positive regulation of transcription from RNA polymerase II promoter|leucine catabolic process carboxy-lyase activity cytosol|nucleus
YEL022W YEL022W GEA2 hom Verified 0.61186143926045 0.270314718028477 no 1374 0.29693869715297 1021 NA FT VESICLE-MEDIATED TRANSPORT|SIGNALING|CYTOSKELETON ORGANIZATION|RESPONSE TO NUTRIENT LEVELS GOLGI APPARATUS Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA2 has a paralog, GEA1, that arose from the whole genome duplication retrograde vesicle-mediated transport, Golgi to ER|secretory granule organization|ER to Golgi vesicle-mediated transport|macroautophagy|intra-Golgi vesicle-mediated transport|actin cytoskeleton organization ARF guanyl-nucleotide exchange factor activity integral to membrane|Golgi cis cisterna|extrinsic to membrane
YDR205W YDR205W MSC2 hom Verified 0.611812175151217 0.270331016724987 no 1375 0.274770654412418 968 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids cellular zinc ion homeostasis|zinc ion transport|transmembrane transport zinc ion transmembrane transporter activity|metal ion transmembrane transporter activity integral to membrane|endoplasmic reticulum
YCR001W_d YCR001W YCR001W hom Dubious 0.610799694749978 0.270666097763635 no 1376 0.244842925449667 827 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR001W is not an essential gene Unknown Unknown Unknown
YKR073C_d YKR073C YKR073C hom Dubious 0.609581161096627 0.271069647095512 no 1377 0.302638353038378 1046 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YJL170C YJL170C ASG7 hom Verified 0.60922181590725 0.271188710937093 no 1378 0.280031727912764 949 NA FT ENDOMEMBRANE SYSTEM|PLASMA MEMBRANE Protein that regulates signaling from a G protein beta subunit Ste4p and its relocalization within the cell; specific to a-cells and induced by alpha-factor conjugation with cellular fusion molecular_function plasma membrane
YMR019W YMR019W STB4 hom Verified 0.607551055167927 0.271742635605711 no 1379 0.260074748193589 856 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Putative transcription factor; contains a Zn(II)2Cys6 zinc finger domain characteristic of DNA-binding proteins; computational analysis suggests a role in regulation of expression of genes encoding transporters; binds Sin3p in a two-hybrid assay; biological_process sequence-specific DNA binding|DNA binding nucleus
YBR174C_d YBR174C YBR174C hom Dubious 0.60727565449015 0.271833996087585 no 1380 0.277162428772483 966 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YBR175W; null mutant is viable and sporulation defective Unknown Unknown Unknown
YJL094C YJL094C KHA1 hom Verified 0.607195085302966 0.271860726724373 no 1381 0.256874103998807 869 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION|GOLGI APPARATUS Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies monovalent inorganic cation transport potassium:hydrogen antiporter activity mitochondrion|integral to membrane|Golgi apparatus
YNL303W_d YNL303W YNL303W hom Dubious 0.606087384570998 0.272228363847731 no 1382 0.258215542043342 873 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGR183C YGR183C QCR9 hom Verified 0.605966468436841 0.272268509909504 no 1383 0.274419152891997 946 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex iron-sulfur cluster assembly|mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration ubiquinol-cytochrome-c reductase activity mitochondrion|integral to membrane|mitochondrial respiratory chain complex III
YPL264C_p YPL264C YPL264C hom Uncharacterized 0.605768676352741 0.272334186339345 no 1384 0.257916334294731 866 NA Putative membrane protein of unknown function; physically interacts with Hsp82p; YPL264C is not an essential gene biological_process molecular_function integral to membrane
YCL021W-A_p YCL021W-A YCL021W-A hom Uncharacterized 0.605647482633695 0.272374432337607 no 1385 0.251456068038108 858 NA Putative protein of unknown function biological_process molecular_function cellular_component
YML102W YML102W CAC2 hom Verified 0.605478924839412 0.272430411904819 no 1386 0.274643853685148 951 NA FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription DNA replication-dependent nucleosome assembly histone binding chromosome, centromeric region|CAF-1 complex
YMR063W YMR063W RIM9 hom Verified 0.60451024513061 0.272752229927057 no 1387 0.312091728523276 1099 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Plasma membrane protein of unknown function; involved in the proteolytic activation of Rim101p in response to alkaline pH; interacts with Rim21p and Dfg16p to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; has similarity to A. nidulans PalI; ascospore formation molecular_function integral to membrane
YPR096C YPR096C YPR096C hom Verified 0.60442968634361 0.272779001930345 no 1388 0.254987938951705 874 NA Protein of unknown function that may interact with ribosomes, based on co-purification experiments biological_process molecular_function ribosome
YDR363W YDR363W ESC2 hom Verified 0.604057448220863 0.272902724297801 no 1389 0.297682260409674 1015 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|GENE SILENCING NUCLEUS Sumo-like domain protein; prevents accumulation of toxic intermediates during replication-associated recombinational repair; roles in silencing, lifespan, chromatid cohesion and the intra-S-phase DNA damage checkpoint; RENi family member intra-S DNA damage checkpoint|double-strand break repair via homologous recombination|chromatin silencing at silent mating-type cassette|mitotic sister chromatid cohesion molecular_function nucleus
YEL006W YEL006W YEA6 hom Verified 0.60375924625576 0.273001859025488 no 1390 0.276928509060865 952 NA FT MITOCHONDRION Putative mitochondrial NAD+ transporter, member of the mitochondrial carrier subfamily (see also YIA6); has putative human ortholog transport|NAD transmembrane transport transporter activity|NAD transporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YEL023C_p YEL023C YEL023C hom Uncharacterized 0.603222090006807 0.273180477121448 no 1391 0.277128247937954 953 NA Putative protein of unknown function; expression is increased greatly during sporulation; YEL023C is not an essential gene biological_process molecular_function cellular_component
YFL055W YFL055W AGP3 hom Verified 0.603032144357106 0.273243652729817 no 1392 0.265759822827992 915 NA FT PLASMA MEMBRANE Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition amino acid transport|transmembrane transport amino acid transmembrane transporter activity integral to membrane|plasma membrane
YNL042W-B_p YNL042W-B YNL042W-B hom Uncharacterized 0.602836096393513 0.273308865546892 no 1393 0.248025284682736 870 NA Putative protein of unknown function biological_process molecular_function cellular_component
YOL061W YOL061W PRS5 hom Verified 0.601669482156573 0.273697084012786 no 1394 0.278426710683997 955 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; forms cytoplasmic foci upon DNA replication stress fungal-type cell wall organization|5-phosphoribose 1-diphosphate biosynthetic process ribose phosphate diphosphokinase activity cytoplasm
YBL094C_d YBL094C YBL094C hom Dubious 0.601610044504768 0.273716870597308 no 1395 0.262323148494739 908 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YBL095W Unknown Unknown Unknown
YCR079W YCR079W PTC6 hom Verified 0.600932514327128 0.273942467992463 no 1396 0.288349351822666 1028 NA FT RESPONSE TO NUTRIENT LEVELS MITOCHONDRION Mitochondrial type 2C protein phosphatase (PP2C) with similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase mitochondrion degradation|positive regulation of catalytic activity|macroautophagy|protein dephosphorylation protein serine/threonine phosphatase activity mitochondrion|mitochondrial matrix|mitochondrial intermembrane space
YDR444W_p YDR444W YDR444W hom Uncharacterized 0.600844718159188 0.273971708229937 no 1397 0.276603361292491 933 NA FT LIPID METABOLISM Putative hydrolase acting on ester bonds biological_process molecular_function cytoplasm
YER038W-A_d YER038W-A YER038W-A hom Dubious 0.59948647617441 0.274424262880186 no 1398 0.282238784209746 940 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 99% of ORF overlaps the verified gene HVG1; protein product detected in mitochondria Unknown Unknown Unknown
YPR026W YPR026W ATH1 hom Verified 0.599175281664366 0.274528002163862 no 1399 0.254533274971594 858 NA FT CARBOHYDRATE METABOLISM Acid trehalase required for utilization of extracellular trehalose trehalose catabolic process|response to stress alpha,alpha-trehalase activity fungal-type cell wall|cell wall-bounded periplasmic space|fungal-type vacuole
YMR219W YMR219W ESC1 hom Verified 0.598836874940711 0.27464083482196 no 1400 0.290614653975257 1006 NA FT GENE SILENCING NUCLEUS Protein localized to the nuclear periphery, involved in telomeric silencing; interacts with PAD4-domain of Sir4p chromatin silencing at telomere molecular_function nuclear periphery
YDL002C YDL002C NHP10 hom Verified 0.598753255439694 0.274668719028653 no 1401 0.285823391293196 981 NA FT CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Protein related to mammalian high mobility group proteins; preferentially binds DNA ends, protecting them from exonucleatic cleavage; likely component of the chromatin-remodeling complex INO80 complex; proposed to be involved in DNA repair double-strand break repair|nucleosome mobilization DNA end binding|loop DNA binding nucleus|Ino80 complex
YIR003W YIR003W AIM21 hom Verified 0.598388047383782 0.274790519625836 no 1402 0.250989013517528 875 NA FT SITE OF POLARIZED GROWTH|CYTOSKELETON Protein of unknown function involved in mitochondrial migration along actin filament; may interact with ribosomes; GFP-fusion protein colocalizes with Sac1p to the actin cytoskeleton mitochondrion migration along actin filament molecular_function ribosome|mating projection tip|actin cytoskeleton
YBR099C_d YBR099C YBR099C hom Dubious 0.59830461594223 0.274818348595035 no 1403 0.263769087411817 888 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4 Unknown Unknown Unknown
YOR220W YOR220W RCN2 hom Verified 0.598236994133504 0.27484090520243 no 1404 0.2676938411879 942 NA Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; phosphorylated in response to alpha factor; protein abundance increases in response to DNA replication stress biological_process molecular_function cytoplasm
YKR077W YKR077W MSA2 hom Verified 0.596770637646988 0.275330262076241 no 1405 0.273940335718599 949 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE NUCLEUS Putative transcriptional activator, that interacts with G1-specific transcription factor, MBF and G1-specific promoters; ortholog of Msa2p, an MBF and SBF activator that regulates G1-specific transcription and cell cycle initiation regulation of transcription involved in G1 phase of mitotic cell cycle molecular_function nucleus|cytoplasm
YPL030W YPL030W TRM44 hom Verified 0.596481297696036 0.275426872098853 no 1406 0.259033407748695 880 NA FT RNA PROCESSING tRNA(Ser) Um(44) 2'-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS(CGA) and tS(UGA); conserved among metazoans and fungi but there does not appear to be a homolog in plants; TRM44 is a non-essential gene tRNA methylation tRNA (uracil) methyltransferase activity cytoplasm
YER016W YER016W BIM1 hom Verified 0.596380212655463 0.275460628119539 no 1407 0.272392774901315 947 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION CHROMOSOME|CYTOSKELETON KINETOCHORE Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally nuclear migration along microtubule|microtubule nucleation|microtubule depolymerization|negative regulation of microtubule depolymerization|positive regulation of microtubule polymerization|mitotic sister chromatid cohesion|mitotic cell cycle spindle assembly checkpoint microtubule plus-end binding|protein homodimerization activity|structural constituent of cytoskeleton spindle midzone|microtubule plus end|cytoplasmic microtubule|spindle pole body|kinetochore|spindle pole|spindle
YCL050C YCL050C APA1 hom Verified 0.596361966666573 0.275466721344535 no 1408 0.277714169053186 945 NA FT NUCLEOTIDE METABOLISM NUCLEUS AP4A phosphorylase; bifunctional diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase and ADP sulfurylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; catalyzes phosphorolysis of dinucleoside oligophosphates, cleaving substrates' alpha/beta-anhydride bond and introducing Pi into the beta-position of the corresponding NDP formed; protein abundance increases under DNA replication stress; APA1 has a paralog, APA2, that arose from the whole genome duplication nucleotide biosynthetic process|nucleoside catabolic process bis(5'-nucleosyl)-tetraphosphatase activity|sulfate adenylyltransferase (ADP) activity nucleus|cytoplasm
YPR199C YPR199C ARR1 hom Verified 0.596183730308294 0.275526246638804 no 1409 0.265301952003183 883 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Transcriptional activator of the basic leucine zipper (bZIP) family, required for transcription of genes involved in resistance to arsenic compounds positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus|cytoplasm
YKL198C YKL198C PTK1 hom Verified 0.595877920615379 0.275628392119837 no 1410 0.275545532515721 933 NA FT PROTEIN PHOSPHORYLATION Putative serine/threonine protein kinase that regulates spermine uptake; involved in polyamine transport; possible mitochondrial protein polyamine transport protein kinase activity cellular_component
YKR047W_d YKR047W YKR047W hom Dubious 0.595819825836339 0.275647798838424 no 1411 0.29947071406419 1018 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NAP1 Unknown Unknown Unknown
YBL085W YBL085W BOI1 hom Verified 0.595691289765918 0.275690739048838 no 1412 0.272413783241656 895 NA FT SIGNALING|CELL DIVISION SITE OF POLARIZED GROWTH Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication cytokinesis, completion of separation|establishment of cell polarity|budding cell apical bud growth|Rho protein signal transduction phospholipid binding site of polarized growth|cellular bud|mating projection tip|cellular bud neck
YBR050C YBR050C REG2 hom Verified 0.595406755411674 0.275785805501123 no 1413 0.241479730104185 812 NA FT TRANSCRIPTION FROM RNA POL II Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease negative regulation of transcription from RNA polymerase II promoter protein phosphatase type 1 regulator activity protein phosphatase type 1 complex
YKR019C YKR019C IRS4 hom Verified 0.595295778042483 0.275822888781355 no 1414 0.394603749521826 1305 NA FF|FT LIPID METABOLISM|SIGNALING|CELL WALL ORG/BIOGENESIS|RESPONSE TO NUTRIENT LEVELS|GENE SILENCING MITOCHONDRION EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication autophagy|fungal-type cell wall organization|chromatin silencing at rDNA|inositol lipid-mediated signaling|CVT pathway|cellular response to starvation molecular_function mitochondrion|pre-autophagosomal structure
YOL137W YOL137W BSC6 hom Verified 0.594631016170597 0.276045071393748 no 1415 0.290285828885323 994 NA FT GOLGI APPARATUS Protein of unknown function containing 8 putative transmembrane seqments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression biological_process molecular_function COPI-coated vesicle|integral to membrane|clathrin-coated vesicle
YML036W YML036W CGI121 hom Verified 0.593570855339643 0.276399589485231 no 1416 0.297425184585126 990 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS|CHROMOSOME Component of the EKC/KEOPS complex with Bud32p, Kae1p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription; Cgi121p is dispensable for tRNA modification telomere maintenance|positive regulation of transcription from RNA polymerase II promoter molecular_function EKC/KEOPS complex
YBR294W YBR294W SUL1 hom Verified 0.593417099423476 0.276451024044233 no 1417 0.250627559286671 832 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE High affinity sulfate permease of the SulP anion transporter family; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates sulfate transport|transmembrane transport sulfate transmembrane transporter activity integral to membrane|plasma membrane
YNL130C YNL130C CPT1 hom Verified 0.593281655079094 0.27649633688885 no 1418 0.265170833404483 924 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS Cholinephosphotransferase; required for phosphatidylcholine biosynthesis and for inositol-dependent regulation of EPT1 transcription; CPT1 has a paralog, EPT1, that arose from the whole genome duplication CDP-choline pathway diacylglycerol cholinephosphotransferase activity mitochondrial outer membrane|integral to membrane|Golgi apparatus
YAL068C YAL068C PAU8 hom Verified 0.593243914218718 0.276508963725453 no 1419 0.254912750830472 870 NA FT TRANSCRIPTION FROM RNA POL II Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions ascospore formation|positive regulation of transcription from RNA polymerase II promoter molecular_function cellular_component
YDR278C_d YDR278C YDR278C hom Dubious 0.592473095155424 0.276766915981964 no 1420 0.264629836858792 891 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YNL333W YNL333W SNZ2 hom Verified 0.591040543730841 0.277246627870264 no 1421 0.275391340455942 944 NA FT COFACTOR METABOLISM Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO2; interacts with Thi11p pyridoxine metabolic process|thiamine biosynthetic process protein binding cellular_component
YLR077W YLR077W FMP25 hom Verified 0.590494325700863 0.277429644422126 no 1422 0.284471870057062 978 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial inner membrane protein required for an early step in assembly of respiratory complex III (cytochrome bc1 complex); mRNA is targeted to mitochondria mitochondrial respiratory chain complex III assembly molecular_function mitochondrion|integral to mitochondrial inner membrane
YPR159W YPR159W KRE6 hom Verified 0.590485840246365 0.277432488035789 no 1423 0.306939894669858 1039 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Type II integral membrane protein required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; localizes to the ER, plasma membrane, sites of polarized growth and secretory vesicles; functionally redundant with Skn1p fungal-type cell wall organization|(1->6)-beta-D-glucan biosynthetic process glucosidase activity integral to endoplasmic reticulum membrane|integral to membrane|site of polarized growth|transport vesicle|plasma membrane
YGR223C YGR223C HSV2 hom Verified 0.590479526397446 0.277434603918386 no 1424 0.282769735285728 956 NA FT MEMBRANE ORGANIZATION|RESPONSE TO NUTRIENT LEVELS Phosphatidylinositol 3,5-bisphosphate-binding protein, plays a role in micronucleophagy; belongs to the PROPPIN family of proteins; predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization piecemeal microautophagy of nucleus phosphatidylinositol binding endosome|fungal-type vacuole|extrinsic to membrane|cytoplasm
YDL162C_d YDL162C YDL162C hom Dubious 0.590220267831098 0.277521492867282 no 1425 0.278500559662908 945 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps ENT1/YDL161W, a verified gene involved in endocytosis and actin cortical patch assembly Unknown Unknown Unknown
YMR318C YMR318C ADH6 hom Verified 0.589740181852772 0.277682425900717 no 1426 0.266187427540805 905 NA FT OXIDATION-REDUCTION PROCESS NADPH-dependent medium chain alcohol dehydrogenase; has broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance; protein abundance increases in response to DNA replication stress cellular aldehyde metabolic process|furaldehyde metabolic process|alcohol metabolic process hydroxymethylfurfural reductase (NADH) activity|hydroxymethylfurfural reductase (NADPH) activity|alcohol dehydrogenase (NADP+) activity cellular_component
YHR013C YHR013C ARD1 hom Verified 0.588875331940536 0.277972453361338 no 1427 0.278670127148768 962 NA FT CHROMATIN ORGANIZATION RIBOSOME Subunit of protein N-terminal acetyltransferase NatA; NatA is comprised of Nat1p, Ard1p, and Nat5p; acetylates many proteins and thus affects telomeric silencing, cell cycle, heat-shock resistance, mating, and sporulation; human Ard1p levels are elevated in cancer cells; protein abundance increases in response to DNA replication stress histone acetylation|N-terminal protein amino acid acetylation peptide alpha-N-acetyltransferase activity cytosolic ribosome|NatA complex
YJL141C YJL141C YAK1 hom Verified 0.588748181706235 0.278015105659574 no 1428 0.266855843194071 924 NA FT PROTEIN PHOSPHORYLATION NUCLEUS Serine-threonine protein kinase; component of a glucose-sensing system that inhibits growth in response to glucose availability; upon nutrient deprivation Yak1p phosphorylates Pop2p to regulate mRNA deadenylation, the co-repressor Crf1p to inhibit transcription of ribosomal genes, and the stress-responsive transcription factors Hsf1p and Msn2p; nuclear localization negatively regulated by the Ras/PKA signaling pathway in the presence of glucose protein phosphorylation protein serine/threonine kinase activity|protein tyrosine kinase activity|protein kinase activity nucleus|cytoplasm
YDR383C YDR383C NKP1 hom Verified 0.588629979188854 0.278054759327528 no 1429 0.292381034935569 985 NA FT CELL CYCLE|CELL DIVISION NUCLEUS|CHROMOSOME KINETOCHORE Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein fta4 biological_process molecular_function kinetochore
YBL090W YBL090W MRP21 hom Verified 0.587573015544715 0.278409463931179 no 1430 0.306692347771403 1044 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit; MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences mitochondrial translational initiation|mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YGL009C YGL009C LEU1 hom Verified 0.586225255285168 0.278862076066932 no 1431 0.277588403765216 961 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway leucine biosynthetic process 3-isopropylmalate dehydratase activity cytosol
YJL106W YJL106W IME2 hom Verified 0.586119301085202 0.278897673353736 no 1432 0.27035557560047 920 NA FT CELL CYCLE|PROTEIN PHOSPHORYLATION NUCLEUS Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p protein phosphorylation|regulation of meiosis protein kinase activity nucleus
YJL214W YJL214W HXT8 hom Verified 0.585576887561912 0.279079941900745 no 1433 0.274916424097475 931 NA FT PLASMA MEMBRANE Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose hexose transport mannose transmembrane transporter activity|glucose transmembrane transporter activity|fructose transmembrane transporter activity integral to membrane|plasma membrane
YKL136W_d YKL136W YKL136W hom Dubious 0.585428241956932 0.279129901757712 no 1434 0.303236148250136 1012 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF APL2/YKL135C Unknown Unknown Unknown
YPL196W YPL196W OXR1 hom Verified 0.583989932279065 0.279613542769369 no 1435 0.267708805388182 950 NA FT RESPONSE TO OXIDATIVE STRESS MITOCHONDRION Protein of unknown function required for normal levels of resistance to oxidative damage, null mutants are sensitive to hydrogen peroxide; member of a conserved family of proteins found in eukaryotes cellular response to oxidative stress molecular_function mitochondrion
YBR086C YBR086C IST2 hom Verified 0.582773699341317 0.280022826183216 no 1436 0.293875347485404 985 NA FT PLASMA MEMBRANE Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localizes to the mother cell in small-budded cells and to the bud in medium- and large-budded cells; mRNA is transported to the bud tip by an actomyosin-driven process response to osmotic stress lipid binding integral to membrane|cellular bud membrane|plasma membrane
YGL006W YGL006W PMC1 hom Verified 0.582634456416642 0.280069702356421 no 1437 0.269212791918075 925 NA FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions; prevents growth inhibition by activation of calcineurin in the presence of elevated concentrations of calcium; similar to mammalian PMCA1a cellular calcium ion homeostasis|calcium ion transport|transmembrane transport calcium-transporting ATPase activity fungal-type vacuole membrane|integral to membrane
YJR094C YJR094C IME1 hom Verified 0.582581116547158 0.280087660247309 no 1438 0.249129789197627 862 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE NUCLEUS Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p pseudohyphal growth|regulation of transcription from RNA polymerase II promoter|regulation of meiosis protein binding transcription factor activity nucleus
YDR503C YDR503C LPP1 hom Verified 0.582438338164161 0.280135732076502 no 1439 0.263060084719049 896 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Lipid phosphate phosphatase, catalyzes Mg(2+)-independent dephosphorylation of phosphatidic acid (PA), lysophosphatidic acid, and diacylglycerol pyrophosphate; involved in control of the cellular levels of phosphatidylinositol and PA phospholipid metabolic process phosphatidate phosphatase activity integral to membrane|membrane
YDL114W_p YDL114W YDL114W hom Uncharacterized 0.582387645629252 0.280152800628049 no 1440 0.284316320309264 970 NA FT OXIDATION-REDUCTION PROCESS Putative short-chain dehydrogenase/reductase; YDL114W is not an essential gene biological_process molecular_function integral to membrane
YLR098C YLR098C CHA4 hom Verified 0.582000573124168 0.280283147416123 no 1441 0.289466516357825 961 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS DNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain positive regulation of transcription, DNA-dependent|cellular amino acid catabolic process sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nucleus
YDR019C YDR019C GCV1 hom Verified 0.581394011145405 0.280487466416707 no 1442 0.294235741720546 1042 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION T subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm glycine catabolic process|glycine metabolic process|one-carbon metabolic process glycine dehydrogenase (decarboxylating) activity mitochondrion|glycine cleavage complex
YCL057W YCL057W PRD1 hom Verified 0.579519009472861 0.281119511875426 no 1443 0.270969408470342 936 NA FT PROTEOLYSIS MITOCHONDRION Zinc metalloendopeptidase; found in the cytoplasm and intermembrane space of mitochondria; with Cym1p, involved in degradation of mitochondrial proteins and of presequence peptides cleaved from imported proteins; protein abundance increases in response to DNA replication stress proteolysis metalloendopeptidase activity mitochondrion|cytoplasm|mitochondrial intermembrane space
YPR124W YPR124W CTR1 hom Verified 0.578168057821121 0.281575330988204 no 1444 0.379609584206585 1249 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE High-affinity copper transporter of the plasma membrane; mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels; protein increases in abundance and relocalizes from nucleus to plasma membrane upon DNA replication stress copper ion import copper uptake transmembrane transporter activity integral to membrane|plasma membrane
YGL157W YGL157W ARI1 hom Verified 0.578059820325008 0.281611866380914 no 1445 0.272474687349572 929 NA FT OXIDATION-REDUCTION PROCESS NUCLEUS NADPH-dependent aldehyde reductase, utilizes aromatic and alophatic aldehyde substrates; member of the short-chain dehydrogenase/reductase superfamily biological_process oxidoreductase activity|carbonyl reductase (NADPH) activity nucleus|cytoplasm
YIL163C_p YIL163C YIL163C hom Uncharacterized 0.577626164385061 0.281758269170261 no 1446 0.271423128347022 925 NA Protein of unknown function; mRNA identified as translated by ribosome profiling data biological_process molecular_function cellular_component
YHL003C YHL003C LAG1 hom Verified 0.577313038118416 0.281864003794586 no 1447 0.256193970104903 867 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress replicative cell aging|ceramide biosynthetic process sphingosine N-acyltransferase activity integral to membrane|endoplasmic reticulum
YLR348C YLR348C DIC1 hom Verified 0.577253588735541 0.281884080469661 no 1448 0.27345230873595 900 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix dicarboxylic acid transport dicarboxylic acid transmembrane transporter activity mitochondrial envelope|mitochondrion|integral to membrane
YML012C-A_d YML012C-A YML012C-A hom Dubious 0.577145083747747 0.281920725509186 no 1449 0.291064114505428 1004 NA FF Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SEL1 Unknown Unknown Unknown
YDR005C YDR005C MAF1 hom Verified 0.576987922212549 0.281973807236715 no 1450 0.294920867647169 1017 NA FT NUCLEUS Highly conserved negative regulator of RNA polymerase III; binds to the N-terminal domain of the Rpc160p subunit of Pol III to prevent closed-complex formation; localization and activity are regulated by phosphorylation, mediated by TORC1, protein kinase A, and Sch9p; localizes to cytoplasm during vegetative growth and translocates to the nucleus and nucleolus under stress conditions negative regulation of transcription from RNA polymerase III promoter RNA polymerase III core binding nucleolus|nucleus|cytoplasm
YNL094W YNL094W APP1 hom Verified 0.576965728095448 0.281981303746848 no 1451 0.307553745259115 1055 NA FT CYTOSKELETON ORGANIZATION CYTOSKELETON Phosphatidate phosphatase, converts phosphatidate to diacylglycerol; App1p, Pah1p, Dpp1p, and Lpp1p are responsible for all the phosphatidate phosphatase activity; component of cortical actin patches; interacts with components of endocytic pathway actin cytoskeleton organization molecular_function actin cytoskeleton|actin cortical patch
YBR189W YBR189W RPS9B hom Verified 0.576901225982035 0.28200309117989 no 1452 0.272401175591447 927 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION NUCLEUS RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog, RPS9A, that arose from the whole genome duplication positive regulation of translational fidelity|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome small-subunit processome|cytosolic small ribosomal subunit|90S preribosome
YPL081W YPL081W RPS9A hom Verified 0.576119173207005 0.282267316353561 no 1453 0.285762718450522 1007 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION NUCLEUS RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9A has a paralog, RPS9B, that arose from the whole genome duplication cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome|rRNA binding small-subunit processome|cytosolic small ribosomal subunit|90S preribosome|cytoplasm
YGL118C_d YGL118C YGL118C hom Dubious 0.575218704918865 0.282571696995152 no 1454 0.282948130356439 981 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOL019W-A_p YOL019W-A YOL019W-A hom Uncharacterized 0.574009758891119 0.282980598732341 no 1455 0.271990082609604 923 NA Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YPL072W YPL072W UBP16 hom Verified 0.573282921624999 0.283226573509704 no 1456 0.259695944853777 887 NA FT PROTEOLYSIS MITOCHONDRION Deubiquitinating enzyme anchored to the outer mitochondrial membrane, probably not important for general mitochondrial functioning, but may perform a more specialized function at mitochondria protein deubiquitination ubiquitin-specific protease activity mitochondrial outer membrane|cytoplasm
YJR083C YJR083C ACF4 hom Verified 0.573250760560428 0.283237459760273 no 1457 0.269028365316968 899 NA Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization; potential Cdc28p substrate biological_process molecular_function cellular_component
YPR002W YPR002W PDH1 hom Verified 0.57267635285365 0.283431925747256 no 1458 0.286083194928542 989 NA FT KETONE METABOLISM MITOCHONDRION Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate propionate metabolic process|propionate catabolic process, 2-methylcitrate cycle 2-methylcitrate dehydratase activity mitochondrial outer membrane|mitochondrion|cytoplasm
YKR082W YKR082W NUP133 hom Verified 0.571838804017783 0.283715592928119 no 1459 0.285730124516179 962 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP133 poly(A)+ mRNA export from nucleus|double-strand break repair|maintenance of chromatin silencing at telomere|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|tRNA export from nucleus|telomere tethering at nuclear periphery|nuclear pore distribution|mRNA export from nucleus in response to heat stress|positive regulation of transcription, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette structural constituent of nuclear pore integral to membrane|nuclear pore|nuclear pore outer ring
YDL127W YDL127W PCL2 hom Verified 0.57150598437706 0.283828352461079 no 1460 0.234524063229078 820 NA FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION NUCLEUS|SITE OF POLARIZED GROWTH Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; localizes to sites of polarized cell growth G1 phase of mitotic cell cycle|regulation of establishment or maintenance of cell polarity|regulation of cyclin-dependent protein kinase activity|septin ring organization cyclin-dependent protein kinase regulator activity cyclin-dependent protein kinase holoenzyme complex|incipient cellular bud site|nucleus|cellular bud neck|cellular bud tip
YLL048C YLL048C YBT1 hom Verified 0.571324280213398 0.283889923014622 no 1461 0.282010813596982 950 NA FT NUCLEOTIDE METABOLISM Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates the release of lumenal Ca2+ stores; similar to mammalian bile transporters bile acid and bile salt transport bile acid-exporting ATPase activity integral to membrane|fungal-type vacuole
YPR062W YPR062W FCY1 hom Verified 0.569969142990691 0.284349313500439 no 1462 0.301339455926723 1030 NA FT NUCLEUS Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU) cytosine metabolic process|pyrimidine-containing compound salvage|cytidine metabolic process cytosine deaminase activity nucleus|cytoplasm
YMR007W_d YMR007W YMR007W hom Dubious 0.569800211714577 0.284406605968937 no 1463 0.248666665344257 859 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YJL199C_d YJL199C MBB1 hom Dubious 0.569788022901482 0.284410739976829 no 1464 0.282460116068111 953 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; protein detected in large-scale protein-protein interaction studies Unknown Unknown Unknown
YHR034C YHR034C PIH1 hom Verified 0.569683732842697 0.284446112595077 no 1465 0.298598889995733 999 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II protein folding|rRNA processing|regulation of cell size|box C/D snoRNP assembly molecular_function R2TP complex|nucleus|small nucleolar ribonucleoprotein complex|cytoplasm
YHR121W YHR121W LSM12 hom Verified 0.569536355240029 0.284496103029917 no 1466 0.280965071427956 940 NA FT NUCLEUS Protein of unknown function that may function in RNA processing; interacts with Pbp1p and Pbp4p and associates with ribosomes; contains an RNA-binding LSM domain and an AD domain; GFP-fusion protein is induced by the DNA-damaging agent MMS; relative distribution to the nucleus increases upon DNA replication stress RNA metabolic process RNA binding ribosome|nucleus|cytoplasmic stress granule|cytoplasm
YAR050W YAR050W FLO1 hom Verified 0.569390798281544 0.284545480021627 no 1467 0.302603432570504 962 NA FT PLASMA MEMBRANE Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p cellular response to stress|flocculation via cell wall protein-carbohydrate interaction|flocculation mannose binding fungal-type cell wall
YBL088C YBL088C TEL1 hom Verified 0.568771754608955 0.284755522655813 no 1468 0.281234550325405 970 NA FT CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION NUCLEUS|MITOCHONDRION|CHROMOSOME Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; regulates P-body formation induced by replication stress; homolog of human ataxia-telangiectasia mutated (ATM) gene, the gene responsible for ataxia telangiectasia (AT) (OMIM 607585) double-strand break repair|histone phosphorylation|telomere maintenance|response to DNA damage stimulus|phosphorylation|DNA damage induced protein phosphorylation protein kinase activity|telomeric DNA binding mitochondrion|nucleus
YCR084C YCR084C TUP1 hom Verified 0.568496860479479 0.284848818448897 no 1469 0.278065542126815 978 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|RESPONSE TO NUTRIENT LEVELS NUCLEUS General repressor of transcription, forms complex with Cyc8p, involved in the establishment of repressive chromatin structure through interactions with histones H3 and H4, appears to enhance expression of some genes nucleosome positioning|regulation of transcription from RNA polymerase II promoter in response to osmotic stress|histone exchange|negative regulation of mating-type specific transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter by glucose|negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter in response to hypoxia|negative regulation of transcription from RNA polymerase II promoter during mitosis|Unknown ubiquitin binding|histone deacetylase binding|histone binding|phosphatidylinositol-3,5-bisphosphate binding|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription|mediator complex binding nucleus|transcriptional repressor complex
YPL230W YPL230W USV1 hom Verified 0.567450592339916 0.285204042712436 no 1470 0.255855664953245 874 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS NUCLEUS Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in growth on non-fermentable carbon sources, response to salt stress and cell wall biosynthesis; USV1 has a paralog, RGM1, that arose from the whole genome duplication carbon catabolite activation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter in response to salt stress sequence-specific DNA binding nucleus
YHL021C YHL021C AIM17 hom Verified 0.566148098473308 0.285646554337095 no 1471 0.277920408279651 917 NA FT OXIDATION-REDUCTION PROCESS MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss biological_process molecular_function mitochondrion
YML118W YML118W NGL3 hom Verified 0.564566748264566 0.286184243813116 no 1472 0.256687571222633 876 NA 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication polyadenylation-dependent RNA catabolic process poly(A)-specific ribonuclease activity|endonuclease activity cellular_component
YBL017C YBL017C PEP1 hom Verified 0.563245735234665 0.286633781845432 no 1473 0.256519879784609 858 NA FT PROTEIN LOCALIZATION|VACUOLAR TRANSPORT GOLGI APPARATUS Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments vacuolar transport|protein targeting to vacuole signal sequence binding integral to membrane|Golgi apparatus
YOR351C YOR351C MEK1 hom Verified 0.563115929568508 0.286677972511755 no 1474 0.278502404460619 964 NA FT CELL CYCLE|PROTEIN PHOSPHORYLATION NUCLEUS Meiosis-specific serine/threonine protein kinase, functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids meiosis|meiotic recombination checkpoint|protein phosphorylation protein serine/threonine kinase activity|protein kinase activity nucleus
YOL109W YOL109W ZEO1 hom Verified 0.562617080970773 0.286847829144882 no 1475 0.29324018792026 989 NA FT CELL WALL ORG/BIOGENESIS MITOCHONDRION|PLASMA MEMBRANE Peripheral membrane protein of the plasma membrane that interacts with Mid2p; regulates the cell integrity pathway mediated by Pkc1p and Slt2p; the authentic protein is detected in a phosphorylated state in highly purified mitochondria fungal-type cell wall organization|response to stress molecular_function mitochondrial outer membrane|mitochondrion|extrinsic to plasma membrane|plasma membrane
YPR067W YPR067W ISA2 hom Verified 0.561986930120977 0.287062461999955 no 1476 0.317998251569588 1082 NA FT KETONE METABOLISM|COFACTOR METABOLISM MITOCHONDRION Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa1p and possibly Iba57p; localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations iron-sulfur cluster assembly|biotin biosynthetic process iron ion binding mitochondrion|mitochondrial intermembrane space
YKL030W_d YKL030W YKL030W hom Dubious 0.561188780808463 0.287334425176635 no 1477 0.27727761823071 907 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene MAE1 Unknown Unknown Unknown
YMR246W YMR246W FAA4 hom Verified 0.561034649660741 0.287386958207769 no 1478 0.281992219019298 975 NA FT KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM Long chain fatty acyl-CoA synthetase; activates imported fatty acids with a preference for C12:0-C16:0 chain lengths; functions in long chain fatty acid import; important for survival during stationary phase; localized to lipid particles; involved in sphingolipid-to-glycerolipid metabolism; forms cytoplasmic foci upon DNA replication stress; FAA4 has a paralog, FAA1, that arose from the whole genome duplication long-chain fatty acid transport|long-chain fatty-acyl-CoA metabolic process long-chain fatty acid-CoA ligase activity lipid particle|cytoplasm
YOR264W YOR264W DSE3 hom Verified 0.559738271540719 0.287828986778559 no 1479 0.275257653041897 959 NA FT CELL CYCLE SITE OF POLARIZED GROWTH Daughter cell-specific protein, may help establish daughter fate; relocalizes from bud neck to cytoplasm upon DNA replication stress biological_process molecular_function cellular bud neck
YHR127W YHR127W YHR127W hom Verified 0.559371469691835 0.287954114178434 no 1480 0.280805614101198 955 NA FT CELL CYCLE|CYTOSKELETON ORGANIZATION NUCLEUS Protein of unknown function; localizes to the nucleus; required for asymmetric localization of Kar9p during mitosis mitotic spindle elongation molecular_function nucleus
YGR258C YGR258C RAD2 hom Verified 0.559192119727922 0.288015305318306 no 1481 0.255856652175515 881 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE NUCLEUS Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein nucleotide-excision repair, DNA incision, 3'-to lesion|transcription from RNA polymerase II promoter single-stranded DNA specific endodeoxyribonuclease activity nucleotide-excision repair factor 3 complex
YKL162C_p YKL162C YKL162C hom Uncharacterized 0.558873449515761 0.288124045283006 no 1482 0.262825087375878 898 NA FT MITOCHONDRION Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion biological_process molecular_function mitochondrion
YNL301C YNL301C RPL18B hom Verified 0.558617053869196 0.288211549333408 no 1483 0.269921354925156 935 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L18B; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18B has a paralog, RPL18A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YMR053C YMR053C STB2 hom Verified 0.558200203692589 0.288353840899095 no 1484 0.276112145233805 954 NA FT NUCLEUS|CHROMOSOME Protein that interacts with Sin3p in a two-hybrid assay and is part of a large protein complex with Sin3p and Stb1p biological_process molecular_function Sin3-type complex
YGL086W YGL086W MAD1 hom Verified 0.557740862675383 0.288510675035968 no 1485 0.280456124796289 941 NA FT CELL CYCLE|CELL DIVISION ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME NUCLEAR PORE|KINETOCHORE Coiled-coil protein involved in the spindle-assembly checkpoint; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon spindle assembly checkpoint arrest; phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of the activity of the anaphase promoting complex; forms a complex with Mad2p nucleocytoplasmic transport|mitotic cell cycle spindle assembly checkpoint|mitotic cell cycle G2/M transition decatenation checkpoint molecular_function nucleus|nuclear pore|kinetochore
YGL165C_d YGL165C YGL165C hom Dubious 0.556912054635272 0.288793759023309 no 1486 0.279860495687681 955 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CUP2/YGL166W Unknown Unknown Unknown
YGR141W YGR141W VPS62 hom Verified 0.556799297662627 0.288832281896067 no 1487 0.269701865596236 920 NA FT PROTEIN LOCALIZATION|VACUOLAR TRANSPORT Vacuolar protein sorting (VPS) protein required for cytoplasm to vacuole targeting of proteins protein targeting to vacuole molecular_function cellular_component
YDR079W YDR079W PET100 hom Verified 0.556252263138746 0.289019207911926 no 1488 0.29154266709661 1022 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme mitochondrial respiratory chain complex IV assembly|aerobic respiration unfolded protein binding mitochondrion|mitochondrial inner membrane|integral to mitochondrial inner membrane
YNL228W_d YNL228W YNL228W hom Dubious 0.554973594062744 0.289456361060488 no 1489 0.309591939986344 1045 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF YNL227C/JJJ1 Unknown Unknown Unknown
YJL189W YJL189W RPL39 hom Verified 0.554835021045279 0.289503755241589 no 1490 0.283745284862791 973 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YNR031C YNR031C SSK2 hom Verified 0.554595300927866 0.289585751947579 no 1491 0.289125044239418 1024 NA FT SIGNALING|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION SITE OF POLARIZED GROWTH MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress MAPK cascade involved in osmosensory signaling pathway|protein autophosphorylation|protein phosphorylation|response to osmotic stress|actin cytoskeleton organization|osmosensory signaling pathway via two-component system MAP kinase kinase kinase activity cytosol|cellular bud neck|cellular bud tip
YMR143W YMR143W RPS16A hom Verified 0.553972532821747 0.289798821863056 no 1492 0.284355559935959 943 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16A has a paralog, RPS16B, that arose from the whole genome duplication cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit|90S preribosome
YKL051W YKL051W SFK1 hom Verified 0.552150598588275 0.290422588802699 no 1493 0.249010288260178 812 NA FT LIPID METABOLISM|SIGNALING|CYTOSKELETON ORGANIZATION PLASMA MEMBRANE Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane vacuole organization|inositol lipid-mediated signaling|actin cytoskeleton organization molecular_function integral to membrane|plasma membrane
YMR116C YMR116C ASC1 hom Verified 0.552149998818731 0.290422794246388 no 1494 0.291992589437411 1010 NA FT SIGNALING|TRANSLATION RIBOSOME G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; regulates P-body formation induced by replication stress; represses Gcn4p in the absence of amino acid starvation negative regulation of translation|glucose mediated signaling pathway|G-protein coupled receptor signaling pathway|invasive growth in response to glucose limitation G-protein alpha-subunit binding|GDP-dissociation inhibitor activity|signal transducer activity cytosolic small ribosomal subunit|cytoplasm
YPR069C YPR069C SPE3 hom Verified 0.551109266048605 0.290779386912973 no 1495 0.324443206444925 1102 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM NUCLEUS Spermidine synthase, involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells spermidine biosynthetic process|pantothenate biosynthetic process spermidine synthase activity nucleus|cytoplasm
YLR107W YLR107W REX3 hom Verified 0.549896843708258 0.291195064608231 no 1496 0.279637970585201 983 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS RNA exonuclease; required for maturation of the RNA component of RNase MRP; functions redundantly with Rnh70p and Rex2p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases U5 snRNA 3'-end processing|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ncRNA 3'-end processing 3'-5'-exoribonuclease activity|3'-5' exonuclease activity nucleus|cytoplasm
YMR040W YMR040W YET2 hom Verified 0.549702714750252 0.291261647271827 no 1497 0.302607995236467 1024 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein biological_process molecular_function ribosome|integral to membrane
YHR138C YHR138C YHR138C hom Verified 0.549471703295688 0.291340889212391 no 1498 0.292805451610378 981 NA FT MEMBRANE ORGANIZATION Protein of unknown function; similar to Pbi2p; double null mutant lacking Pbi2p and Yhr138cp exhibits highly fragmented vacuoles; protein abundance increases in response to DNA replication stress vacuole fusion, non-autophagic endopeptidase inhibitor activity cellular_component
YML086C YML086C ALO1 hom Verified 0.549018997502824 0.291496206289159 no 1499 0.270402971401494 916 NA FT OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS MITOCHONDRION D-Arabinono-1,4-lactone oxidase, catalyzes the final step in biosynthesis of dehydro-D-arabinono-1,4-lactone, which is protective against oxidative stress cellular response to oxidative stress|dehydro-D-arabinono-1,4-lactone biosynthetic process D-arabinono-1,4-lactone oxidase activity mitochondrial outer membrane|mitochondrion|integral to mitochondrial outer membrane
YBL053W_d YBL053W YBL053W hom Dubious 0.547674086507115 0.29195785422857 no 1500 0.293982682884533 1023 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YJL196C YJL196C ELO1 hom Verified 0.546075807056711 0.292506914530256 no 1501 0.269215665985627 917 NA FT KETONE METABOLISM|LIPID METABOLISM Elongase I, medium-chain acyl elongase; catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids; ELO1 has a paralog, FEN1, that arose from the whole genome duplication fatty acid elongation, unsaturated fatty acid fatty acid elongase activity integral to membrane|membrane
YPR047W YPR047W MSF1 hom Verified 0.545951106799998 0.292549773246192 no 1502 0.323939477906921 1114 NA FT KETONE METABOLISM|RNA PROCESSING|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial phenylalanyl-tRNA synthetase, active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase phenylalanyl-tRNA aminoacylation|mitochondrial phenylalanyl-tRNA aminoacylation phenylalanine-tRNA ligase activity mitochondrion
YKR034W YKR034W DAL80 hom Verified 0.545857892291965 0.29258181240862 no 1503 0.289008374287931 997 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS NUCLEUS Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Gzf3p; DAL80 has a paralog, GZF3, that arose from the whole genome duplication nitrogen catabolite repression of transcription|negative regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity nucleus
YGL192W YGL192W IME4 hom Verified 0.545535878038129 0.29269250586533 no 1504 0.313504910320405 1077 NA FT CELL CYCLE NUCLEUS Probable mRNA N6-adenosine methyltransferase required for entry into meiosis; transcribed in diploid cells; haploids repress IME4 transcription via production of antisense IME4 transcripts; antisense transcription is repressed in diploids meiosis|mRNA methylation mRNA (N6-adenosine)-methyltransferase activity cellular_component
YIL134C-A_p YIL134C-A YIL134C-A hom Uncharacterized 0.544715231952931 0.29297469356481 no 1505 0.286353942483089 998 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YGL230C_p YGL230C YGL230C hom Uncharacterized 0.54453370968746 0.293037128930937 no 1506 0.276573660353485 931 NA Putative protein of unknown function; non-essential gene biological_process molecular_function cellular_component
YOR296W_p YOR296W YOR296W hom Uncharacterized 0.544516186656892 0.293043156379548 no 1507 0.259062054147516 887 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; expressed during copper starvation; YOR296W is not an essential gene biological_process molecular_function cytoplasm
YGL226C-A YGL226C-A OST5 hom Verified 0.544335596263271 0.293105277941266 no 1508 0.291237087907102 1008 NA FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Zeta subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins protein N-linked glycosylation dolichyl-diphosphooligosaccharide-protein glycotransferase activity oligosaccharyltransferase complex
YPL104W YPL104W MSD1 hom Verified 0.543403373694773 0.293426051685032 no 1509 0.317146097301882 1111 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial aspartyl-tRNA synthetase, required for acylation of aspartyl-tRNA; yeast and bacterial aspartyl-, asparaginyl-, and lysyl-tRNA synthetases contain regions with high sequence similarity, suggesting a common ancestral gene mitochondrial aspartyl-tRNA aminoacylation aspartate-tRNA ligase activity mitochondrion
YDL107W YDL107W MSS2 hom Verified 0.543321231531498 0.293454324241987 no 1510 0.299618911364314 1045 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Peripherally bound inner membrane protein of the mitochondrial matrix involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p protein insertion into mitochondrial membrane from inner side molecular_function extrinsic to mitochondrial inner membrane|mitochondrial matrix
YHR139C YHR139C SPS100 hom Verified 0.542372172785076 0.293781072777168 no 1511 0.302511488744964 1053 NA FT KETONE METABOLISM|CELL CYCLE|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall; expression also induced in cells treated with the mycotoxin patulin ascospore wall assembly molecular_function ascospore wall
YKL168C YKL168C KKQ8 hom Verified 0.542264437549419 0.293818175248863 no 1512 0.281715859152972 949 NA FT PROTEIN PHOSPHORYLATION Putative serine/threonine protein kinase with unknown cellular role; KKQ8 has a paralog, HAL5, that arose from the whole genome duplication biological_process protein kinase activity cytoplasm
YBR163W YBR163W EXO5 hom Verified 0.541774138368107 0.293987054637656 no 1513 0.292494191560227 1032 NA FT MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial 5'-3' exonuclease and sliding exonuclease, required for mitochondrial genome maintenance; distantly related to the RecB nuclease domain of bacterial RecBCD recombinases; may be regulated by the transcription factor Ace2 mitochondrial genome maintenance single-stranded DNA specific 5'-3' exodeoxyribonuclease activity mitochondrion
YKR089C YKR089C TGL4 hom Verified 0.541592726785312 0.294049551689375 no 1514 0.291362487557215 993 NA FT LIPID METABOLISM|CELL DIVISION Multifunctional triacylglycerol lipase, steryl ester hydrolase, and Ca2+-independent phospholipase A2; catalyzes acyl-CoA dependent acylation of LPA to PA; required with Tgl3p for timely bud formation; phosphorylated and activated by Cdc28p phospholipid metabolic process|triglyceride catabolic process|triglyceride mobilization|cell budding lysophosphatidic acid acyltransferase activity|triglyceride lipase activity|calcium-independent phospholipase A2 activity|sterol esterase activity lipid particle
YOR365C_p YOR365C YOR365C hom Uncharacterized 0.541478813131795 0.294088798559831 no 1515 0.27448303352012 923 NA Putative protein of unknown function; not an essential protein; YOR365C has a paralog, FLC2, that arose from the whole genome duplication biological_process molecular_function integral to membrane
YPR045C YPR045C THP3 hom Verified 0.541018949833026 0.294247260676538 no 1516 0.281650081610844 1001 NA FT RNA PROCESSING NUCLEUS|CHROMOSOME Protein that forms a complex with Csn12p that is recruited to transcribed genes and may have a role in transcription elongation; possibly involved in splicing based on pre-mRNA accumulation defect for many intron-containing genes mRNA splicing, via spliceosome molecular_function nucleus|transcriptionally active chromatin
YLR237W YLR237W THI7 hom Verified 0.540189062926184 0.294533327243491 no 1517 0.313762764905871 1048 NA FT PLASMA MEMBRANE Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia thiamine transport thiamine transmembrane transporter activity integral to membrane|plasma membrane
YCR037C YCR037C PHO87 hom Verified 0.539921578692273 0.29462555786684 no 1518 0.300331140656032 1033 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Low-affinity inorganic phosphate (Pi) transporter; involved in activation of PHO pathway; expression is independent of Pi concentration and Pho4p activity; contains 12 membrane-spanning segments; PHO87 has a paralog, PHO90, that arose from the whole genome duplication phosphate ion transport|transmembrane transport inorganic phosphate transmembrane transporter activity integral to membrane|membrane
YOR263C_d YOR263C YOR263C hom Dubious 0.539853752738237 0.294648946895353 no 1519 0.295082560278427 1013 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF DES3/YOR264W Unknown Unknown Unknown
YCL005W YCL005W LDB16 hom Verified 0.539361039291641 0.29481887936989 no 1520 0.324010935278694 1122 NA FT MITOCHONDRION Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria biological_process molecular_function mitochondrion|lipid particle
YOR208W YOR208W PTP2 hom Verified 0.539094397149086 0.294910860704152 no 1521 0.285713780537843 979 NA FT PROTEIN LOCALIZATION|SIGNALING|PROTEIN PHOSPHORYLATION NUCLEUS Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the nucleus inactivation of MAPK activity involved in osmosensory signaling pathway|inactivation of MAPK activity involved in cell wall biogenesis|regulation of sporulation|regulation of protein localization|protein dephosphorylation protein tyrosine phosphatase activity nucleus
YLR393W YLR393W ATP10 hom Verified 0.53891175903029 0.294973871495868 no 1522 0.287460110105985 962 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, interacts genetically with ATP6 mitochondrial proton-transporting ATP synthase complex assembly unfolded protein binding integral to mitochondrial membrane|mitochondrion|mitochondrial inner membrane
YER088C YER088C DOT6 hom Verified 0.538548622779644 0.295099173200169 no 1523 0.306446720260604 1056 NA FT TRANSCRIPTION FROM RNA POL II|GENE SILENCING NUCLEUS|CHROMOSOME Protein involved in rRNA and ribosome biogenesis; binds polymerase A and C motif; subunit of the RPD3L histone deacetylase complex; has chromatin specific SANT domain; involved in telomeric gene silencing and filamentation; DOT6 has a paralog, TOD6, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress chromatin silencing at rDNA|filamentous growth|regulation of transcription from RNA polymerase II promoter|unidimensional cell growth|chromatin silencing at telomere sequence-specific DNA binding Rpd3L-Expanded complex|nucleus|Rpd3L complex|cytoplasm
YAR035C-A_p YAR035C-A YAR035C-A hom Uncharacterized 0.53725344646022 0.295546278785029 no 1524 0.27835935841003 966 NA Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; predicted to have a role in cell budding based on computational guilt by association analysis biological_process molecular_function cellular_component
YOR031W YOR031W CRS5 hom Verified 0.536753480739314 0.295718954375982 no 1525 0.288355653436403 989 NA Copper-binding metallothionein, required for wild-type copper resistance response to metal ion copper ion binding cytoplasm
YLR451W YLR451W LEU3 hom Verified 0.536211114706101 0.29590632637525 no 1526 0.29419403131546 974 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Zinc-knuckle transcription factor, repressor and activator; regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; acts as a repressor in leucine-replete conditions and as an activator in the presence of alpha-isopropylmalate, an intermediate in leucine biosynthesis that accumulates during leucine starvation negative regulation of transcription from RNA polymerase II promoter|Unknown|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YER139C YER139C RTR1 hom Verified 0.535724237953233 0.296074574832919 no 1527 0.281701561249219 962 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS CTD phosphatase; dephosphorylates S5-P in the C-terminal domain of Rpo21p; has a cysteine-rich motif required for function and conserved in eukaryotes; shuttles between the nucleus and cytoplasm; RTR1 has a paralog, RTR2, that arose from the whole genome duplication dephosphorylation of RNA polymerase II C-terminal domain|transcription from RNA polymerase II promoter CTD phosphatase activity nucleus|cytoplasm
YBL001C YBL001C ECM15 hom Verified 0.534991997654294 0.296327695426855 no 1528 0.283287049635933 946 NA FT CELL WALL ORG/BIOGENESIS NUCLEUS Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis fungal-type cell wall organization molecular_function nucleus|cytoplasm
YLR368W YLR368W MDM30 hom Verified 0.534731454832498 0.296417783714422 no 1529 0.28578726247614 983 NA FT MEMBRANE ORGANIZATION|PROTEOLYSIS|MITOCHONDRION ORGANIZATION|RNA LOCALIZATION MITOCHONDRION UBIQUITIN LIGASE COMPLEX F-box component of an SCF ubiquitin protein ligase complex; associates with and is required for Fzo1p ubiquitination and for mitochondria fusion; stimulates nuclear export of specific mRNAs; promotes ubiquitin-mediated degradation of Gal4p in some strains SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|chronological cell aging|proteolysis involved in cellular protein catabolic process|mitochondrion organization|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of mRNA export from nucleus|mitochondrial fusion ubiquitin-protein ligase activity mitochondrion|SCF ubiquitin ligase complex
YIR029W YIR029W DAL2 hom Verified 0.534237076154713 0.296588760283169 no 1530 0.284841989222264 975 NA Allantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation allantoin catabolic process allantoicase activity cellular_component
YML101C-A_d YML101C-A YML101C-A hom Dubious 0.533255782801337 0.296928265822333 no 1531 0.292316765497091 969 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDL129W YDL129W YDL129W hom Verified 0.532326993390195 0.297249769871813 no 1532 0.259139171638245 863 NA FT NUCLEUS Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YDL129W is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress biological_process molecular_function nucleus|cytoplasm
YDR234W YDR234W LYS4 hom Verified 0.532272894049462 0.297268501470204 no 1533 0.309159617196123 1061 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway lysine biosynthetic process via aminoadipic acid homoaconitate hydratase activity mitochondrion
YOR130C YOR130C ORT1 hom Verified 0.532255276478995 0.297274601573254 no 1534 0.28273495458146 965 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Ornithine transporter of the mitochondrial inner membrane, exports ornithine from mitochondria as part of arginine biosynthesis; human ortholog is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome arginine biosynthetic process|mitochondrial ornithine transport L-ornithine transmembrane transporter activity mitochondrial envelope|integral to membrane
YDL135C YDL135C RDI1 hom Verified 0.529939153543035 0.298077059237573 no 1535 0.271924959810739 920 NA FT MEMBRANE ORGANIZATION|SIGNALING|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH Rho GDP dissociation inhibitor; involved in the localization and regulation of Cdc42p and Rho1p; protein abundance increases in response to DNA replication stress regulation of vacuole fusion, non-autophagic|actin filament organization|small GTPase mediated signal transduction Rho GDP-dissociation inhibitor activity cytosol|plasma membrane|cellular bud neck|cellular bud tip
YJR010W YJR010W MET3 hom Verified 0.529557663578719 0.298209327125334 no 1536 0.304662346359791 1048 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)|sulfur amino acid metabolic process sulfate adenylyltransferase (ATP) activity mitochondrion|cytoplasm
YIL123W YIL123W SIM1 hom Verified 0.529437728413823 0.298250915840715 no 1537 0.294103480254765 1000 NA FT CELL WALL ORG/BIOGENESIS Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated fungal-type cell wall organization molecular_function fungal-type cell wall
YEL036C YEL036C ANP1 hom Verified 0.529374719155136 0.298272765988183 no 1538 0.336701037900022 1114 NA FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol protein N-linked glycosylation alpha-1,6-mannosyltransferase activity|mannosyltransferase activity alpha-1,6-mannosyltransferase complex|Golgi cis cisterna
YPL061W YPL061W ALD6 hom Verified 0.528937108676953 0.298424539243524 no 1539 0.296891931657156 1022 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM MITOCHONDRION Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress response to salt stress|NADPH regeneration|acetate biosynthetic process aldehyde dehydrogenase [NAD(P)+] activity cytosol|mitochondrion
YJR108W YJR108W ABM1 hom Verified 0.528668329744227 0.298517775301685 no 1540 0.28414008961134 970 NA FT CYTOSKELETON ORGANIZATION Protein of unknown function, required for normal microtubule organization microtubule cytoskeleton organization molecular_function cellular_component
YML035C YML035C AMD1 hom Verified 0.52844149203642 0.29859647278184 no 1541 0.295727828897318 1009 NA FT NUCLEOTIDE METABOLISM AMP deaminase; tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; thought to be involved in regulation of intracellular purine (adenine, guanine, and inosine) nucleotide pools guanine salvage|purine nucleotide metabolic process AMP deaminase activity cytoplasm
YLR420W YLR420W URA4 hom Verified 0.528105557039294 0.298713037039093 no 1542 0.308819853453392 1070 NA FT NUCLEOTIDE METABOLISM NUCLEUS Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate 'de novo' pyrimidine nucleobase biosynthetic process|pyrimidine nucleotide biosynthetic process dihydroorotase activity nucleus|cytoplasm
YNL218W YNL218W MGS1 hom Verified 0.527413778079024 0.298953138791553 no 1543 0.262217686499337 885 NA FT RESPONSE TO DNA DAMAGE NUCLEUS Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress regulation of DNA repair|DNA replication, Okazaki fragment processing|DNA strand renaturation ubiquitin binding|single-stranded DNA-dependent ATPase activity|enzyme activator activity nucleus|cytoplasm
YJR056C YJR056C YJR056C hom Verified 0.526647516827863 0.29921919403464 no 1544 0.250814298139592 870 NA FT NUCLEUS Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress biological_process molecular_function nucleus|cytoplasm
YOR134W YOR134W BAG7 hom Verified 0.526550675629115 0.299252826124719 no 1545 0.294825849991686 1029 NA FT SIGNALING Rho GTPase activating protein (RhoGAP), stimulates the intrinsic GTPase activity of Rho1p, which plays a role in actin cytoskeleton organization and control of cell wall synthesis; structurally and functionally related to Sac7p small GTPase mediated signal transduction Rho GTPase activator activity intracellular
YGR205W YGR205W TDA10 hom Verified 0.525557731279668 0.299597765798874 no 1546 0.274060845405974 927 NA FT NUCLEUS ATP-binding protein of unknown function; crystal structure resembles that of E.coli pantothenate kinase and other small kinases; null mutant is sensitive to expression of the top1-T722A allele biological_process ATP binding nucleus|cytoplasm
YJL209W YJL209W CBP1 hom Verified 0.523510554695353 0.30030950400339 no 1547 0.290476395296962 991 NA FT RNA PROCESSING|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Mitochondrial protein, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex at the inner membrane along with Pet309p; localizes to mitochondrial foci upon DNA replication stress mitochondrial mRNA catabolic process|aerobic respiration mRNA binding mitochondrion|extrinsic to mitochondrial inner membrane
YGR096W YGR096W TPC1 hom Verified 0.523383218167063 0.300353800099788 no 1548 0.33405391180912 1119 NA FT MITOCHONDRION Mitochondrial membrane transporter that mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family thiamine pyrophosphate transport thiamine transmembrane transporter activity integral to membrane|integral to mitochondrial inner membrane
YNL199C YNL199C GCR2 hom Verified 0.523277452240522 0.300390594753636 no 1549 0.31603159554613 1106 NA FT TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY ENDOMEMBRANE SYSTEM|NUCLEUS Transcriptional activator of genes involved in glycolysis; interacts and functions with the DNA-binding protein Gcr1p positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter|regulation of glycolysis by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II activating transcription factor binding|RNA polymerase II transcription factor binding transcription factor activity nuclear envelope|nucleus
YOL132W YOL132W GAS4 hom Verified 0.522708699195667 0.300588491794977 no 1550 0.28912690386703 968 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM PLASMA MEMBRANE 1,3-beta-glucanosyltransferase, involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall ascospore wall assembly 1,3-beta-glucanosyltransferase activity fungal-type cell wall|integral to membrane
YER053C-A YER053C-A YER053C-A hom Verified 0.521926781900213 0.30086065516522 no 1551 0.282991085008131 955 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress biological_process molecular_function endoplasmic reticulum
YPL110C YPL110C GDE1 hom Verified 0.521749818693556 0.300922266490094 no 1552 0.309859093209626 1067 NA FT LIPID METABOLISM|SIGNALING|CARBOHYDRATE METABOLISM Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes glycerophospholipid catabolic process glycerophosphocholine phosphodiesterase activity ribosome|cytoplasm
YOL088C YOL088C MPD2 hom Verified 0.521650542077812 0.300956833023788 no 1553 0.365337849845872 1212 NA FT ENDOPLASMIC RETICULUM Member of the protein disulfide isomerase (PDI) family, exhibits chaperone activity; overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions; undergoes oxidation by Ero1p protein folding protein disulfide isomerase activity|protein disulfide oxidoreductase activity endoplasmic reticulum
YLR373C YLR373C VID22 hom Verified 0.52106514148925 0.301160696561344 no 1554 0.314912729653818 1074 NA FT PROTEIN LOCALIZATION NUCLEUS|PLASMA MEMBRANE Glycosylated integral membrane protein localized to the plasma membrane; plays a role in fructose-1,6-bisphosphatase (FBPase) degradation; involved in FBPase transport from the cytosol to Vid (vacuole import and degradation) vesicles vacuolar protein catabolic process molecular_function integral to plasma membrane
YGL147C YGL147C RPL9A hom Verified 0.519770818716883 0.30161166026679 no 1555 0.303739135271778 1058 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L9A; nearly identical to paralog Rpl9Bp; homologous to mammalian ribosomal protein L9 and bacterial L6 cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YAL048C YAL048C GEM1 hom Verified 0.519732839888603 0.301624897311794 no 1556 0.281422653827808 981 NA FT SIGNALING|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION Outer mitochondrial membrane GTPase, subunit of the ERMES complex; potential regulatory subunit of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; ortholog of metazoan Miro GTPases mitochondrion inheritance|regulation of mitochondrion organization|phospholipid homeostasis GTPase activity|calcium ion binding mitochondrial outer membrane|ERMES complex|mitochondrion
YLR406C YLR406C RPL31B hom Verified 0.518636996215281 0.302006952383195 no 1557 0.329856181189227 1110 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L31B; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31B has a paralog, RPL31A, that arose from the whole genome duplication cytoplasmic translation|regulation of translational fidelity structural constituent of ribosome cytosolic large ribosomal subunit
YGL217C_d YGL217C YGL217C hom Dubious 0.518449395145769 0.30207237942658 no 1558 0.285598122937078 966 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF KIP3/YGL216W Unknown Unknown Unknown
YHR104W YHR104W GRE3 hom Verified 0.515711261565691 0.303028044009753 no 1559 0.301894285448664 1020 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS NUCLEUS Aldose reductase; involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress galactose catabolic process|cellular response to oxidative stress|arabinose catabolic process|D-xylose catabolic process|response to stress D-xylose:NADP reductase activity|mRNA binding|glucose 1-dehydrogenase (NADP+) activity|alditol:NADP+ 1-oxidoreductase activity nucleus|cytoplasm
YBR289W YBR289W SNF5 hom Verified 0.515694844397706 0.303033778014888 no 1560 0.332380823785584 1069 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS NUCLEUS|CHROMOSOME RSC COMPLEX Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf6p; relocates to the cytosol under hypoxic conditions sucrose catabolic process|double-strand break repair via homologous recombination|chromatin remodeling|carbon catabolite activation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II activating transcription factor binding SWI/SNF complex|nucleus
YLR119W YLR119W SRN2 hom Verified 0.513187529415079 0.30391007419444 no 1561 0.31042411325422 1070 NA FT PROTEIN LOCALIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus protein targeting to membrane|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein targeting to vacuole protein binding endosome|ESCRT I complex
YOR303W YOR303W CPA1 hom Verified 0.512626671442576 0.304106246290545 no 1562 0.283308531067535 950 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Small subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader arginine biosynthetic process carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity carbamoyl-phosphate synthase complex
YDR158W YDR158W HOM2 hom Verified 0.512353744871393 0.304201728615061 no 1563 0.333974305192276 1149 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS NUCLEUS Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis methionine biosynthetic process|threonine biosynthetic process|homoserine biosynthetic process aspartate-semialdehyde dehydrogenase activity nucleus|plasma membrane|cytoplasm
YKR009C YKR009C FOX2 hom Verified 0.512122321364096 0.304282701711822 no 1564 0.270227008423546 936 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities fatty acid beta-oxidation enoyl-CoA hydratase activity|3-hydroxyacyl-CoA dehydrogenase activity peroxisome
YLR403W YLR403W SFP1 hom Verified 0.51186027455398 0.304374401225189 no 1565 0.293243771584337 1012 NA FT TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS NUCLEUS Regulates transcription of ribosomal protein and biogenesis genes; regulates response to nutrients and stress, G2/M transitions during mitotic cell cycle and DNA-damage response, and modulates cell size; regulated by TORC1 and Mrs6p; sequence of zinc finger, ChIP localization data, and protein-binding microarray (PBM) data, and computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p at others; can form the [ISP+] prion positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter|regulation of cell size|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription factor binding transcription factor activity nucleus|cytoplasm
YGR166W YGR166W TRS65 hom Verified 0.510937616858325 0.304697369889782 no 1566 0.340330228012135 1126 NA FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|CELL WALL ORG/BIOGENESIS GOLGI APPARATUS Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p; involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi; role in cell wall beta-glucan biosynthesis and the stress response intra-Golgi vesicle-mediated transport|protein complex assembly Rab guanyl-nucleotide exchange factor activity TRAPP complex|trans-Golgi network
YGL156W YGL156W AMS1 hom Verified 0.510669461223187 0.304791264114236 no 1567 0.305259375687495 1042 NA FT CARBOHYDRATE METABOLISM Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway oligosaccharide catabolic process|cellular carbohydrate metabolic process alpha-mannosidase activity fungal-type vacuole membrane
YBR175W YBR175W SWD3 hom Verified 0.509846521812236 0.305079495164164 no 1568 0.300135188524971 1017 NA FT CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5 histone H3-K4 methylation|telomere maintenance|chromatin silencing at telomere histone methyltransferase activity (H3-K4 specific) Set1C/COMPASS complex
YDR146C YDR146C SWI5 hom Verified 0.507746511951706 0.305815562572544 no 1569 0.292031769043248 991 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE NUCLEUS Transcription factor that recruits Mediator and Swi/Snf complexes; activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; required for expression of the HO gene controlling mating type switching; localization to nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase; SWI5 has a paralog, ACE2, that arose from the whole genome duplication positive regulation of mating type switching|regulation of transcription involved in G1 phase of mitotic cell cycle|positive regulation of transcription on exit from mitosis, from RNA polymerase II promoter RNA polymerase II distal enhancer sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity|mediator complex binding nucleus|cytoplasm
YCL061C YCL061C MRC1 hom Verified 0.50712040484203 0.3060351693464 no 1570 0.324773762866439 1108 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|GENE SILENCING NUCLEUS|CHROMOSOME S-phase checkpoint protein required for DNA replication; interacts with and stabilizes Pol2p at stalled replication forks during stress, where it forms a pausing complex with Tof1p and is phosphorylated by Mec1p; protects uncapped telomeres maintenance of DNA repeat elements|intra-S DNA damage checkpoint|DNA repair|DNA replication checkpoint|telomere maintenance|replication fork protection|DNA replication|mitotic sister chromatid cohesion|chromatin silencing at silent mating-type cassette|chromatin silencing at telomere molecular_function nuclear chromosome|replication fork protection complex|nucleus|nuclear replication fork
YOR223W YOR223W YOR223W hom Verified 0.505730979550602 0.306522758619193 no 1571 0.304702110514159 1024 NA FT ENDOPLASMIC RETICULUM Subunit of the DSC ubiquitin ligase complex; protein of unknown function that localizes to the ER and vacuole lumen; overexpression affects endocytic protein trafficking; ortholog of fission yeast dsc3 biological_process molecular_function fungal-type vacuole lumen|endoplasmic reticulum
YHL023C YHL023C NPR3 hom Verified 0.504970782025388 0.306789678887604 no 1572 0.324762710439837 1090 NA FT CELL CYCLE|SIGNALING|RESPONSE TO NUTRIENT LEVELS Subunit of SEA (Seh1-associated), Npr2/3, and Iml1p complexes; Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation; SEA complex is a coatomer-related complex that associates dynamically with the vacuole; Iml1p complex (Iml1p-Npr2p-Npr3p) is required for non-nitrogen-starvation (NNS)-induced autophagy; required for Npr2p phosphorylation and Iml1p-Npr2p interaction; null mutant shows delayed meiotic DNA replication and double-strand break repair meiosis|regulation of TOR signaling cascade|cellular response to amino acid starvation molecular_function Seh1-associated complex|extrinsic to fungal-type vacuolar membrane
YDL177C_p YDL177C YDL177C hom Uncharacterized 0.504680820849337 0.306891516953005 no 1573 0.285892380556309 985 NA Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene biological_process molecular_function cellular_component
YBR278W YBR278W DPB3 hom Verified 0.503735806756601 0.307223521368171 no 1574 0.314396638214564 1071 NA FT RESPONSE TO DNA DAMAGE|GENE SILENCING NUCLEUS|CHROMOSOME Third-largest subunit of DNA polymerase II (DNA polymerase epsilon); required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; mRNA abundance peaks at the G1/S boundary of the cell cycle; DPB3 has a paralog, DLS1, that arose from the whole genome duplication DNA-dependent DNA replication|chromatin silencing at telomere double-stranded DNA binding|single-stranded DNA binding|DNA-directed DNA polymerase activity epsilon DNA polymerase complex
YMR174C YMR174C PAI3 hom Verified 0.503186732938665 0.307416495804074 no 1575 0.298013246086085 1036 NA Cytoplasmic proteinase A (Pep4p) inhibitor, dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact vacuolar protein catabolic process endopeptidase inhibitor activity cytoplasm
YOL051W YOL051W GAL11 hom Verified 0.502622631654825 0.307614807242007 no 1576 0.365817506305327 1218 NA FF|FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors; forms part of the tail domain of mediator negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly|TFIIE-class binding transcription factor activity|RNA polymerase II activating transcription factor binding|TFIIE-class transcription factor binding|TFIIH-class transcription factor binding|RNA polymerase II transcription factor recruiting transcription factor activity core mediator complex
YFR025C YFR025C HIS2 hom Verified 0.502018312543771 0.307827319764297 no 1577 0.281586580071697 940 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Histidinolphosphatase, catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control histidine biosynthetic process histidinol-phosphatase activity intracellular
YBR039W YBR039W ATP3 hom Verified 0.501704790727167 0.307937597042307 no 1578 0.329847034521904 1121 NA FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS MITOCHONDRION Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis ATP synthesis coupled proton transport proton-transporting ATPase activity, rotational mechanism mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase, central stalk
YHR086W-A_p YHR086W-A YHR086W-A hom Uncharacterized 0.500925055694848 0.30821193404337 no 1579 0.300691971928777 1034 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YDL160C-A YDL160C-A MHF2 hom Verified 0.500342934595241 0.308416813698514 no 1580 0.31748495546269 1073 NA FT RESPONSE TO DNA DAMAGE Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM to stabilize and remodel blocked replication forks and repair damaged DNA; mhf2 srs2 double mutants are MMS hypersensitive; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-X, also known as MHF2 response to DNA damage stimulus molecular_function cellular_component
YMR030W YMR030W RSF1 hom Verified 0.49995411690624 0.308553692757677 no 1581 0.289132370918641 983 NA FT TRANSCRIPTION FROM RNA POL II|SIGNALING|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS|MITOCHONDRION Protein required for respiratory growth; localized to both the nucleus and mitochondrion; may interact with transcription factors to mediate the transition to respiratory growth and activate transcription of nuclear and mitochondrial genes transcription from mitochondrial promoter|calcium-mediated signaling|transcription from RNA polymerase II promoter|aerobic respiration molecular_function mitochondrion|nucleus
YJL190C YJL190C RPS22A hom Verified 0.499602095607107 0.30867764099876 no 1582 0.308798927525276 1057 NA FT TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22A has a paralog, RPS22B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic small ribosomal subunit
YGL219C YGL219C MDM34 hom Verified 0.498550745542928 0.309047955700023 no 1583 0.347868398581888 1139 NA FT MITOCHONDRION ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION Mitochondrial component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth mitochondrion organization|phospholipid transport molecular_function mitochondrial outer membrane|ERMES complex|mitochondrion|cytoplasm
YPR040W YPR040W TIP41 hom Verified 0.497674525932105 0.309356732936884 no 1584 0.322760534729095 1109 NA FT SIGNALING NUCLEUS Protein that interacts with Tap42p, which regulates PP2A; component of the TOR (target of rapamycin) signaling pathway; protein abundance increases in response to DNA replication stress signal transduction molecular_function nucleus|cytoplasm
YHL013C YHL013C OTU2 hom Verified 0.497434958776442 0.309441179156809 no 1585 0.286190757767237 996 NA Protein of unknown function; may interact with ribosomes, based on co-purification experiments; member of the ovarian tumor-like (OTU) superfamily of predicted cysteine proteases; shows cytoplasmic localization; protein abundance increases in response to DNA replication stress biological_process molecular_function ribosome|cytoplasm
YMR173W YMR173W DDR48 hom Verified 0.497321976208204 0.309481008437592 no 1586 0.293606418268721 1001 NA FT RESPONSE TO DNA DAMAGE DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress DNA repair ATPase activity|GTPase activity cytoplasm
YLL054C_p YLL054C YLL054C hom Uncharacterized 0.497240572783677 0.309509706639688 no 1587 0.312654981938874 1060 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene biological_process sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity cellular_component
YMR100W YMR100W MUB1 hom Verified 0.494452760275432 0.310493230388025 no 1588 0.325570496661605 1076 NA FT CELL DIVISION MYND domain-containing protein required for ubiquitination and turnover of Rpn4p; interacts with Ubr2p (E3) and indirectly with Rad6p (E2); short-lived protein degraded in a Ubr2p/Rad6p dependent manner; similar to the A. nidulans samB gene regulation of cell budding|protein monoubiquitination molecular_function cellular_component
YGL210W YGL210W YPT32 hom Verified 0.493810947330109 0.310719850524497 no 1589 0.281962870309353 954 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING ENDOMEMBRANE SYSTEM|MITOCHONDRION|GOLGI APPARATUS Rab family GTPase involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; protein abundance increases in response to DNA replication stress; YPT32 has a paralog, YPT31, that arose from the whole genome duplication early endosome to Golgi transport|vesicle-mediated transport|exocytosis GTPase activity endosome|mitochondrial outer membrane|Golgi apparatus
YML047C YML047C PRM6 hom Verified 0.492703394466575 0.31111108941356 no 1590 0.30263549844004 1036 NA Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; regulated by Ste12p during mating; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family biological_process molecular_function integral to membrane
YOL124C YOL124C TRM11 hom Verified 0.492071707685842 0.311334326053654 no 1591 0.314548119530048 1055 NA FT RNA PROCESSING Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain tRNA methylation S-adenosylmethionine-dependent methyltransferase activity|RNA binding|tRNA (guanine-N2-)-methyltransferase activity cytoplasm|tRNA (m2G10) methyltransferase complex
YHR037W YHR037W PUT2 hom Verified 0.490358733349325 0.311940036278092 no 1592 0.326995787089033 1084 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION Delta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism glutamate biosynthetic process|proline catabolic process to glutamate 1-pyrroline-5-carboxylate dehydrogenase activity mitochondrion|mitochondrial matrix
YAL037C-A_p YAL037C-A YAL037C-A hom Uncharacterized 0.489188632797662 0.312354078212199 no 1593 0.314770531793913 1083 NA Putative protein of unknown function biological_process molecular_function cellular_component
YJR145C YJR145C RPS4A hom Verified 0.488817697753421 0.312485383674086 no 1594 0.306225489803836 1041 NA FT TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4A has a paralog, RPS4B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic small ribosomal subunit|cytoplasm|90S preribosome
YDR134C YDR134C YDR134C hom pseudogene 0.488484071254663 0.312603502807441 no 1595 0.301278999457164 1035 NA Hypothetical protein; YDR134C has a paralog, CCW12, that arose from the whole genome duplication biological_process molecular_function fungal-type cell wall
YNL105W_d YNL105W RRT16 hom Dubious 0.488304902147477 0.312666944862542 no 1596 0.286518122733901 982 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription Unknown Unknown Unknown
YMR258C YMR258C ROY1 hom Verified 0.487458995023662 0.31296654736883 no 1597 0.319602595380584 1103 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|NUCLEUS GTPase inhibitor with similarity to F-box proteins; inhibits Ypt52p GTPase activity by preventing Ypt52p from binding GTP; involved in regulating intracellular trafficking; physically interacts with Skp1p endocytosis|protein targeting to vacuole|negative regulation of GTPase activity GTPase inhibitor activity nucleus|cytoplasm
YBL008W-A_p YBL008W-A YBL008W-A hom Uncharacterized 0.486785265836588 0.313205256478899 no 1598 0.306720173638763 1030 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YFR030W YFR030W MET10 hom Verified 0.486709698195214 0.313232035748836 no 1599 0.312172365638919 1051 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY Subunit alpha of assimilatory sulfite reductase, which converts sulfite into sulfide sulfate assimilation sulfite reductase (NADPH) activity sulfite reductase complex (NADPH)
YGL087C YGL087C MMS2 hom Verified 0.486663543374667 0.313248392339956 no 1600 0.308105511353762 1030 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE NUCLEUS Ubiquitin-conjugating enzyme variant; involved in error-free postreplication repair; forms a heteromeric complex with Ubc13p, an active ubiquitin-conjugating enzyme; cooperates with chromatin-associated RING finger proteins, Rad18p and Rad5p; protein abundance increases in response to DNA replication stress postreplication repair|response to DNA damage stimulus|protein polyubiquitination|free ubiquitin chain polymerization ubiquitin-protein ligase activity ubiquitin conjugating enzyme complex|nucleus|cytoplasm
YDL072C YDL072C YET3 hom Verified 0.48618556358853 0.313417802961224 no 1601 0.311280456613786 1072 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein; protein abundance increases in response to DNA replication stress biological_process molecular_function integral to membrane|endoplasmic reticulum
YOR269W YOR269W PAC1 hom Verified 0.485669382642404 0.313600797457711 no 1602 0.283839906676693 947 NA FT CELL CYCLE|CELL DIVISION NUCLEUS|CYTOSKELETON Involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; serves at interface between dynein's ATPase site and its microtubule binding stalk, causing individual dynein motors to remain attached to microtubules for long periods; synthetic lethal with bni1; homolog of human LIS1, mutations in which cause the severe brain disorder lissencephaly nuclear migration along microtubule microtubule plus-end binding cytoplasmic microtubule|nucleus|cytoplasm
YNR024W YNR024W MPP6 hom Verified 0.485596595479891 0.313626605376307 no 1603 0.312101316128807 1029 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Nuclear exosome-associated RNA binding protein; involved in surveillance of pre-rRNAs and pre-mRNAs, and the degradation of cryptic non-coding RNAs (ncRNA); copurifies with ribosomes nuclear mRNA surveillance of spliceosomal pre-mRNA splicing|nuclear mRNA surveillance of mRNA 3'-end processing|nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) poly(U) RNA binding ribosome|nucleus|nuclear exosome (RNase complex)|TRAMP complex
YDL067C YDL067C COX9 hom Verified 0.485195872818443 0.313768704700652 no 1604 0.320078622071855 1052 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain mitochondrial electron transport, cytochrome c to oxygen cytochrome-c oxidase activity mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YDR505C YDR505C PSP1 hom Verified 0.484305802730054 0.314084429190212 no 1605 0.304734138071906 1009 NA FT MITOCHONDRION Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication biological_process molecular_function mitochondrion|cytoplasm
YNL084C YNL084C END3 hom Verified 0.483891215750654 0.314231537419904 no 1606 0.341164594418573 1192 NA FF|FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p bipolar cellular bud site selection|ascospore wall assembly|endocytosis|actin filament organization|cytokinesis|actin cortical patch assembly protein binding, bridging mating projection tip|actin cortical patch
YDL071C_d YDL071C YDL071C hom Dubious 0.48385274990741 0.314245187782402 no 1607 0.339732762483434 1161 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF BDF2/YDL070W Unknown Unknown Unknown
YOR211C YOR211C MGM1 hom Verified 0.483179423480784 0.314484172066645 no 1608 0.307966628500658 1035 NA FT MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p; required for mt morphology and genome maintenance; exists as long and short form with different distributions; homolog of human OPA1 involved in autosomal dominant optic atrophy mitochondrion organization|mitochondrial genome maintenance|mitochondrial fusion GTPase activity intrinsic to mitochondrial inner membrane|extrinsic to mitochondrial inner membrane|mitochondrion|mitochondrial inner boundary membrane|mitochondrial crista|mitochondrial intermembrane space
YHL019C YHL019C APM2 hom Verified 0.483125416727344 0.314503344096502 no 1609 0.308775609023558 1052 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport Golgi to vacuole transport|vesicle-mediated transport clathrin binding AP-1 adaptor complex
YEL013W YEL013W VAC8 hom Verified 0.481515636937289 0.315075034453507 no 1610 0.303020662620225 1042 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Phosphorylated and palmitoylated vacuolar membrane protein that interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions piecemeal microautophagy of nucleus|vacuole inheritance|CVT vesicle assembly|vacuole fusion, non-autophagic|macroautophagy|nucleus-vacuole junction assembly protein anchor fungal-type vacuole membrane|nucleus-vacuole junction|Myo2p-Vac17p-Vac8p transport complex
YER066W_p YER066W RRT13 hom Uncharacterized 0.481244554017875 0.315171349332742 no 1611 0.28863628555442 1025 NA Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription biological_process molecular_function cellular_component
YHR025W YHR025W THR1 hom Verified 0.479802771291519 0.315683821056473 no 1612 0.334767818550322 1126 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway threonine biosynthetic process|methionine metabolic process|isoleucine metabolic process|homoserine metabolic process homoserine kinase activity cellular_component
YPL033C YPL033C SRL4 hom Verified 0.479604787354853 0.315754220792043 no 1613 0.314583111059129 1059 NA FT NUCLEOTIDE METABOLISM Protein of unknown function; involved in regulation of dNTP production; null mutant suppresses the lethality of lcd1 and rad53 mutations; expression is induced by Kar4p deoxyribonucleoside triphosphate metabolic process molecular_function cellular_component
YJR074W YJR074W MOG1 hom Verified 0.478641168960951 0.316096962587986 no 1614 0.313535546346395 1047 NA FT PROTEIN LOCALIZATION|RNA LOCALIZATION NUCLEUS Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p protein import into nucleus Ran GTPase binding nucleus
YBR024W YBR024W SCO2 hom Verified 0.476246582581476 0.316949358196525 no 1615 0.312511153427374 1047 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Protein anchored to mitochondrial inner membrane; may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p; SCO2 has a paralog, SCO1, that arose from the whole genome duplication copper ion transport thioredoxin peroxidase activity mitochondrial envelope|mitochondrion
YMR122C_d YMR122C YMR122C hom Dubious 0.475377981316415 0.317258792856541 no 1616 0.342683628009104 1156 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YBR262C YBR262C AIM5 hom Verified 0.475270204708596 0.317297196625645 no 1617 0.271590739763291 919 NA FT MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture cristae formation molecular_function mitochondrion|mitochondrial crista junction|integral to mitochondrial inner membrane
YBR115C YBR115C LYS2 hom Verified 0.47434439438963 0.317627169293984 no 1618 0.305133865979175 1018 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS Alpha aminoadipate reductase, catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p lysine biosynthetic process via aminoadipic acid L-aminoadipate-semialdehyde dehydrogenase activity cytoplasm
YGL196W YGL196W DSD1 hom Verified 0.473873633164385 0.3177950112492 no 1619 0.320578566745292 1110 NA FT KETONE METABOLISM|AMINO ACID METABOLISM D-serine dehydratase (aka D-serine ammonia-lyase); converts D-serine to pyruvate and ammonia by a reaction dependent on pyridoxal 5'-phosphate and zinc; may play a role in D-serine detoxification; L-serine is not a substrate D-serine metabolic process D-serine ammonia-lyase activity cellular_component
YMR126C_p YMR126C DLT1 hom Uncharacterized 0.473669797844705 0.317867696904948 no 1620 0.302459242433123 1032 NA Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA) biological_process molecular_function cellular_component
YMR261C YMR261C TPS3 hom Verified 0.4734284903281 0.317953753846789 no 1621 0.310565692635372 1051 NA FT CARBOHYDRATE METABOLISM Regulatory subunit of trehalose-6-phosphate synthase/phosphatase; involved in synthesis of storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; TPS3 has a paralog, TSL1, that arose from the whole genome duplication trehalose biosynthetic process|response to stress enzyme regulator activity|alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity|trehalose-phosphatase activity alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
YFR031C-A YFR031C-A RPL2A hom Verified 0.471255793398577 0.318729040056499 no 1622 0.31623284800955 1065 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L2A; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2A has a paralog, RPL2B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YLL052C YLL052C AQY2 hom Verified 0.470441233677181 0.319019905286296 no 1623 0.320521563760198 1091 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains water transport water channel activity plasma membrane|endoplasmic reticulum membrane
YER122C YER122C GLO3 hom Verified 0.470085926917304 0.31914681413143 no 1624 0.322635820348443 1086 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|NUCLEOTIDE METABOLISM ENDOMEMBRANE SYSTEM|GOLGI APPARATUS ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Gcs1p retrograde vesicle-mediated transport, Golgi to ER|COPI coating of Golgi vesicle|ER to Golgi vesicle-mediated transport ARF GTPase activator activity COPI-coated vesicle|endoplasmic reticulum-Golgi intermediate compartment|COPI vesicle coat
YPR140W YPR140W TAZ1 hom Verified 0.469826446183175 0.319239509129563 no 1625 0.319968308723503 1052 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|LIPID METABOLISM|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; human ortholog tafazzin is implicated in Barth syndrome cardiolipin acyl-chain remodeling|mitochondrial ATP synthesis coupled electron transport|protein complex assembly|inner mitochondrial membrane organization|cardiolipin metabolic process|phospholipid biosynthetic process 1-acylglycerophosphocholine O-acyltransferase activity mitochondrial outer membrane|mitochondrion|mitochondrial inner membrane|integral to mitochondrial outer membrane
YDR471W YDR471W RPL27B hom Verified 0.469326385683315 0.319418178953636 no 1626 0.315351023660047 1056 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L27B; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27B has a paralog, RPL27A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YNR050C YNR050C LYS9 hom Verified 0.469046090789982 0.319518345657894 no 1627 0.329209738589757 1109 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, the seventh step in lysine biosynthesis pathway; exhibits genetic and physical interactions with TRM112 lysine biosynthetic process via aminoadipic acid saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity cytoplasm
YBR275C YBR275C RIF1 hom Verified 0.466316702812396 0.320494412391668 no 1628 0.303698200965046 1008 NA FT CELL CYCLE|GENE SILENCING NUCLEUS|CHROMOSOME Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation telomere capping|telomere maintenance|chromatin silencing at silent mating-type cassette telomeric DNA binding nuclear telomere cap complex
YPL257W_p YPL257W YPL257W hom Uncharacterized 0.46423715945311 0.321238920411433 no 1629 0.30510536681611 1045 NA FT CELL CYCLE Putative protein of unknown function; homozygous diploid deletion strain exhibits low budding index; physically interacts with Hsp82p; YPL257W is not an essential gene biological_process molecular_function integral to membrane
YDR344C_d YDR344C YDR344C hom Dubious 0.463732888583578 0.321419565445953 no 1630 0.314472090017735 1047 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR375W YLR375W STP3 hom Verified 0.4634495757109 0.321521075200019 no 1631 0.333757848989897 1094 NA FT NUCLEUS Zinc-finger protein of unknown function, possibly involved in pre-tRNA splicing and in uptake of branched-chain amino acids biological_process sequence-specific DNA binding nucleus
YPR173C YPR173C VPS4 hom Verified 0.463116777896322 0.321640332215059 no 1632 0.346693594062333 1147 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|LIPID METABOLISM|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT ENDOPLASMIC RETICULUM AAA-ATPase involved in multivesicular body (MVB) protein sorting, ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism late endosome to vacuole transport via multivesicular body sorting pathway|protein retention in Golgi apparatus|intralumenal vesicle formation|protein homooligomerization|sterol metabolic process|late endosome to vacuole transport ATPase activity|protein homodimerization activity|ATP binding endosome|endoplasmic reticulum|membrane|cytoplasm
YPR058W YPR058W YMC1 hom Verified 0.462056706324944 0.322020327896489 no 1633 0.315524145084523 1054 NA FT MITOCHONDRION Putative mitochondrial inner membrane transporter; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; YMC1 has a paralog, YMC2, that arose from the whole genome duplication mitochondrial transport organic acid transmembrane transporter activity mitochondrion|integral to membrane
YIR030C YIR030C DCG1 hom Verified 0.46164599541233 0.322167602326549 no 1634 0.315938465271734 1097 NA Protein of unknown function, expression is sensitive to nitrogen catabolite repression and regulated by Dal80p; contains transmembrane domain nitrogen compound metabolic process molecular_function cellular_component
YDL036C YDL036C PUS9 hom Verified 0.460973268345468 0.322408891924684 no 1635 0.306167989351827 1026 NA FT RNA PROCESSING NUCLEUS|MITOCHONDRION Mitochondrial tRNA:pseudouridine synthase, catalyzes the formation of pseudouridine at position 32 in mitochondrial tRNAs; contains an N-terminal mitochondrial targeting sequence tRNA pseudouridine synthesis pseudouridine synthase activity mitochondrion|nucleus|cytoplasm
YMR072W YMR072W ABF2 hom Verified 0.460967708566435 0.322410886383885 no 1636 0.328581347042588 1095 NA FT MITOCHONDRION ORGANIZATION NUCLEUS|MITOCHONDRION|CHROMOSOME Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation mitochondrion inheritance|mitochondrial DNA packaging|mitochondrial genome maintenance DNA binding, bending|DNA binding mitochondrial nucleoid|mitochondrial chromosome|mitochondrion
YMR244C-A YMR244C-A COA6 hom Verified 0.460961821929262 0.322412998102458 no 1637 0.312963516500969 1050 NA FT NUCLEUS|MITOCHONDRION Protein involved in cytochrome c oxidase assembly; also required for efficient formation of respiratory supercomplexes comprised of Complexes III and IV; localizes to the mitochondrial intermembrane space; has a human homolog; transcription is induced in response to the DNA-damaging agent MMS; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus|cytoplasm
YGR017W_p YGR017W YGR017W hom Uncharacterized 0.460391518645825 0.32261761066546 no 1638 0.296947332223942 973 NA FT OXIDATION-REDUCTION PROCESS NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm biological_process molecular_function nucleus|cytoplasm
YIL086C_d YIL086C YIL086C hom Dubious 0.460014607884161 0.322752867640164 no 1639 0.311672055616174 1052 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGR229C YGR229C SMI1 hom Verified 0.459635744501074 0.322888848962299 no 1640 0.361158416202544 1202 NA FF|FT CELL CYCLE|CELL WALL ORG/BIOGENESIS NUCLEUS|SITE OF POLARIZED GROWTH Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity regulation of mitotic cell cycle|regulation of fungal-type cell wall biogenesis molecular_function incipient cellular bud site|cellular bud neck|mating projection tip
YGL063W YGL063W PUS2 hom Verified 0.459572041215462 0.322911715617352 no 1641 0.315581823752151 1083 NA FT RNA PROCESSING MITOCHONDRION Mitochondrial tRNA:pseudouridine synthase; acts at positions 27 and 28, but not at position 72; efficiently and rapidly targeted to mitochondria, specifically dedicated to mitochondrial tRNA modification tRNA pseudouridine synthesis pseudouridine synthase activity mitochondrion
YGR232W YGR232W NAS6 hom Verified 0.459179888104453 0.32305249593945 no 1642 0.326629928308249 1102 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS NUCLEUS Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); ortholog of human oncoprotein gankyrin, which interacts with the Rb tumor suppressor and CDK4/6 proteolysis|proteasome regulatory particle assembly molecular_function cytosol|nucleus|proteasome regulatory particle
YGL051W YGL051W MST27 hom Verified 0.458796217163521 0.323190255755624 no 1643 0.303757868679049 1058 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS|PLASMA MEMBRANE Putative integral membrane protein, involved in vesicle formation; forms complex with Mst28p; member of DUP240 gene family; binds COPI and COPII vesicles vesicle organization molecular_function integral to membrane|Golgi apparatus|endoplasmic reticulum|plasma membrane
YDR133C_d YDR133C YDR133C hom Dubious 0.458569919487493 0.323271520938481 no 1644 0.307161154480825 1040 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C Unknown Unknown Unknown
YDR217C YDR217C RAD9 hom Verified 0.458124895449286 0.323431356985936 no 1645 0.315273697886679 1078 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME DNA damage-dependent checkpoint protein; required for cell-cycle arrest in G1/S, intra-S, and G2/M; transmits checkpoint signal by activating Rad53p and Chk1p; hyperphosphorylated by Mec1p and Tel1p; multiple cyclin dependent kinase consensus sites and the C-terminal BRCT domain contribute to DNA damage checkpoint activation; potential Cdc28p substrate DNA repair|mitotic cell cycle G1/S transition DNA damage checkpoint|regulation of cell cycle|intra-S DNA damage checkpoint|nucleotide-excision repair|DNA damage checkpoint|positive regulation of transcription from RNA polymerase II promoter double-stranded DNA binding|histone binding chromatin|nucleus
YDR122W YDR122W KIN1 hom Verified 0.457007471902494 0.323832837471782 no 1646 0.298623341308715 1006 NA FT VESICLE-MEDIATED TRANSPORT|PROTEIN PHOSPHORYLATION PLASMA MEMBRANE Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p protein autophosphorylation|exocytosis|protein phosphorylation protein serine/threonine kinase activity|protein kinase activity internal side of plasma membrane|plasma membrane
YMR225C YMR225C MRPL44 hom Verified 0.455736122474975 0.324289871551842 no 1647 0.326160194082036 1109 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YMR257C YMR257C PET111 hom Verified 0.45566138000628 0.32431674877606 no 1648 0.336167050017099 1154 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membrane mitochondrial respiratory chain complex IV biogenesis|positive regulation of mitochondrial translation translation regulator activity mitochondrion|mitochondrial inner membrane
YIL108W YIL108W YIL108W hom Verified 0.455216538633882 0.324476731668861 no 1649 0.293901811661605 971 NA FT PROTEOLYSIS Putative metalloendopeptidase; forms cytoplasmic foci upon DNA replication stress biological_process molecular_function cytoplasm
YGL163C YGL163C RAD54 hom Verified 0.455161970949931 0.324496358639559 no 1650 0.392235700435498 1302 NA FF|FT CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS DNA-dependent ATPase that stimulates strand exchange; modifies the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family; forms nuclear foci upon DNA replication stress positive regulation of endodeoxyribonuclease activity|DNA geometric change|heteroduplex formation|telomere maintenance via recombination|double-strand break repair via synthesis-dependent strand annealing|chromatin remodeling|double-strand break repair via single-strand annealing DNA-dependent ATPase activity|DNA translocase activity nucleus
YML074C YML074C FPR3 hom Verified 0.454025146256188 0.324905363921815 no 1651 0.303532636286736 1027 NA FT CELL CYCLE|CHROMATIN ORGANIZATION NUCLEUS Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p meiotic recombination checkpoint peptidyl-prolyl cis-trans isomerase activity|macrolide binding nucleolus
YGR238C YGR238C KEL2 hom Verified 0.45393033512492 0.324939484490606 no 1652 0.312999652683283 1074 NA FT CELL CYCLE SITE OF POLARIZED GROWTH Protein that functions in a complex with Kel1p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate conjugation with cellular fusion|negative regulation of exit from mitosis molecular_function mating projection tip|cellular bud neck|cellular bud tip
YDR497C YDR497C ITR1 hom Verified 0.453609549401916 0.325054939537958 no 1653 0.313291949215375 1040 NA FT PLASMA MEMBRANE Myo-inositol transporter; has strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p; relative distribution to the vacuole increases upon DNA replication stress myo-inositol transport|transmembrane transport myo-inositol transmembrane transporter activity integral to membrane|plasma membrane|membrane
YDR466W YDR466W PKH3 hom Verified 0.45346562561113 0.32510674508469 no 1654 0.363946937493267 1239 NA FF|FT SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant MAPK cascade involved in cell wall biogenesis|protein phosphorylation protein kinase activity cellular_component
YLR251W YLR251W SYM1 hom Verified 0.451838407814676 0.325692699160188 no 1655 0.316806605948786 1056 NA FT MITOCHONDRION Protein required for ethanol metabolism; induced by heat shock and localized to the inner mitochondrial membrane; homologous to mammalian peroxisomal membrane protein Mpv17 ethanol metabolic process molecular_function mitochondrion|integral to membrane|mitochondrial inner membrane
YLR169W_d YLR169W YLR169W hom Dubious 0.451735481325233 0.325729777048276 no 1656 0.305637222262015 1016 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDL018C YDL018C ERP3 hom Verified 0.451564901658084 0.325791229882764 no 1657 0.337115659588369 1120 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport vesicle-mediated transport molecular_function integral to membrane
YCR085W_d YCR085W YCR085W hom Dubious 0.451064396265643 0.325971568695596 no 1658 0.316976063755951 1080 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YBR058C YBR058C UBP14 hom Verified 0.450745590971987 0.326086459753696 no 1659 0.310811468318355 1075 NA FT KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS NUCLEUS Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase T protein deubiquitination|negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process ubiquitin-specific protease activity cytoplasm
YDR490C YDR490C PKH1 hom Verified 0.449568861917427 0.326510672265714 no 1660 0.314673985833176 1069 NA FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh2p regulation of nuclear-transcribed mRNA poly(A) tail shortening|endocytosis|protein phosphorylation|MAPK cascade involved in cell wall biogenesis|cytoplasmic mRNA processing body assembly protein kinase activity cytosol|cell cortex|eisosome
YLL014W YLL014W EMC6 hom Verified 0.447592125298918 0.327223793684404 no 1661 0.361822215982315 1220 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93 protein folding in endoplasmic reticulum molecular_function ER membrane protein complex|integral to membrane|endoplasmic reticulum
YHR180W_d YHR180W YHR180W hom Dubious 0.446782999731311 0.327515873529007 no 1662 0.317342873783045 1079 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGR189C YGR189C CRH1 hom Verified 0.445968036940952 0.327810167258691 no 1663 0.314824387652006 1067 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress fungal-type cell wall organization|cell wall chitin metabolic process transferase activity, transferring glycosyl groups incipient cellular bud site|fungal-type cell wall
YLR325C YLR325C RPL38 hom Verified 0.445421603168527 0.328007551567759 no 1664 0.341650904419457 1149 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L38; homologous to mammalian ribosomal protein L38, no bacterial homolog cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YFR056C_d YFR056C YFR056C hom Dubious 0.444343829585283 0.328397008702648 no 1665 0.321696068086844 1074 NA Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W Unknown Unknown Unknown
YLR360W YLR360W VPS38 hom Verified 0.444320507087483 0.328405438429709 no 1666 0.315491601685653 1058 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT GOLGI APPARATUS Part of a Vps34p phosphatidylinositol 3-kinase complex that functions in carboxypeptidase Y (CPY) sorting; binds Vps30p and Vps34p to promote production of phosphatidylinositol 3-phosphate (PtdIns3P) which stimulates kinase activity; required for overflow degradation of misfolded proteins when ERAD is saturated ER-associated protein catabolic process|late endosome to vacuole transport molecular_function phosphatidylinositol 3-kinase complex II
YKL069W YKL069W YKL069W hom Verified 0.443793325795625 0.328596007114885 no 1667 0.333577322166777 1128 NA FT OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS NUCLEUS Methionine-R-sulfoxide reductase; reduces the R enantiomer of free Met-SO, in contrast to Ycl033Cp which reduces Met-R-SO in a peptide linkage; has a role in protection against oxidative stress; relative distribution to the nucleus increases upon DNA replication stress cellular response to oxidative stress methionine-R-sulfoxide reductase activity nucleus|cytoplasm
YPR091C YPR091C NVJ2 hom Verified 0.443669125944326 0.328640910120742 no 1668 0.310917493928091 1043 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments biological_process lipid binding ribosome|nucleus-vacuole junction|endoplasmic reticulum
YFR026C YFR026C ULI1 hom Verified 0.442652018544162 0.329008726476783 no 1669 0.330793862036102 1122 NA FT SIGNALING Putative protein of unknown function involved in and induced by the endoplasmic reticulum unfolded protein response endoplasmic reticulum unfolded protein response molecular_function cellular_component
YOL091W YOL091W SPO21 hom Verified 0.442606119021656 0.329025329020749 no 1670 0.312703892980012 1032 NA FT CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION CYTOSKELETON Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation ascospore wall assembly|meiosis structural molecule activity spindle pole body
YOL068C YOL068C HST1 hom Verified 0.441791141611154 0.329320174678654 no 1671 0.336429937646296 1156 NA FT CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME NAD(+)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing and mitotic repression; non-essential subunit of the Set3C deacetylase complex; involved in telomere maintenance chromatin silencing|negative regulation of mitotic recombination|histone deacetylation NAD-independent histone deacetylase activity|NAD-dependent histone deacetylase activity Set3 complex
YOR330C YOR330C MIP1 hom Verified 0.44041765233223 0.329817321082975 no 1672 0.306457364313649 1017 NA FT MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit mitochondrial DNA replication 3'-5' exonuclease activity|DNA-directed DNA polymerase activity mitochondrion
YDR261C YDR261C EXG2 hom Verified 0.440032951290879 0.329956620935252 no 1673 0.320600856477058 1091 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM PLASMA MEMBRANE Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor fungal-type cell wall organization glucan exo-1,3-beta-glucosidase activity fungal-type cell wall
YJL161W_p YJL161W FMP33 hom Uncharacterized 0.439507094712021 0.330147071209462 no 1674 0.313579764594323 1063 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YHR093W_d YHR093W AHT1 hom Dubious 0.439260990028943 0.330236218440372 no 1675 0.323641068453844 1075 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; multicopy suppressor of glucose transport defects, likely due to the presence of an HXT4 regulatory element in the region Unknown Unknown Unknown
YFR009W YFR009W GCN20 hom Verified 0.43919713867083 0.330259349082412 no 1676 0.36112859307241 1225 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|NUCLEOTIDE METABOLISM RIBOSOME Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA regulation of translational elongation ATPase activity cytosol|cytosolic ribosome
YCL044C YCL044C MGR1 hom Verified 0.43904719732166 0.330313669031117 no 1677 0.321908536035 1090 NA FT PROTEOLYSIS MITOCHONDRION Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr3p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA misfolded or incompletely synthesized protein catabolic process misfolded protein binding mitochondrion|i-AAA complex
YPL031C YPL031C PHO85 hom Verified 0.438929119764427 0.330356448052931 no 1678 0.369853288679166 1220 NA FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES A NUCLEUS Cyclin-dependent kinase, with ten cyclin partners; involved in regulating the cellular response to nutrient levels and environmental conditions and progression through the cell cycle regulation of transcription involved in G1/S phase of mitotic cell cycle|negative regulation of calcium-mediated signaling|regulation of protein stability|regulation of protein localization|protein phosphorylation|response to DNA damage stimulus|negative regulation of phosphate metabolic process|fungal-type cell wall organization|regulation of establishment or maintenance of cell polarity|negative regulation of glycogen biosynthetic process|negative regulation of transcription from RNA polymerase II promoter|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of macroautophagy|negative regulation of macroautophagy protein kinase activity|cyclin-dependent protein kinase activity cyclin-dependent protein kinase holoenzyme complex|nucleus
YGR161W-C_p YGR161W-C YGR161W-C hom Uncharacterized 0.438080558805773 0.33066394345068 no 1679 0.303585520647429 1056 NA Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species biological_process molecular_function cellular_component
YML066C YML066C SMA2 hom Verified 0.437289604124663 0.330950666855108 no 1680 0.30165577173876 1012 NA FT MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS ENDOPLASMIC RETICULUM Meiosis-specific prospore membrane protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation ascospore wall assembly|spore membrane bending pathway molecular_function integral to membrane|prospore membrane|cytoplasm
YLR402W_d YLR402W YLR402W hom Dubious 0.434991251380072 0.33178438884349 no 1681 0.340183072261373 1150 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YNL243W YNL243W SLA2 hom Verified 0.434412798650107 0.331994352691198 no 1682 0.335292840751551 1109 NA FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON Adaptor protein that links actin to clathrin and endocytosis; involved in membrane cytoskeleton assembly and cell polarization; present in the actin cortical patch of the emerging bud tip; dimer in vivo bipolar cellular bud site selection|fungal-type cell wall organization|actin filament organization|endocytosis|exocytosis protein binding, bridging incipient cellular bud site|mating projection tip|actin cortical patch
YLR319C YLR319C BUD6 hom Verified 0.434371555714544 0.332009324859393 no 1683 0.343558976758284 1157 NA FT CELL CYCLE|CHROMATIN ORGANIZATION|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Actin- and formin-interacting protein; stimulates actin cable nucleation by recruiting actin monomers to Bni1p; involved in polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate bipolar cellular bud site selection|positive regulation of formin-nucleated actin cable assembly|cellular bud site selection|Rho protein signal transduction|extrachromosomal circular DNA localization involved in cell aging|establishment of cell polarity|response to osmotic stress|cytokinesis cytoskeletal regulatory protein binding polarisome|actin cap|spindle pole body|mating projection tip
YLR395C YLR395C COX8 hom Verified 0.434161814523014 0.33208547005893 no 1684 0.342155924450008 1157 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain mitochondrial electron transport, cytochrome c to oxygen cytochrome-c oxidase activity mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YKL160W YKL160W ELF1 hom Verified 0.433493331392835 0.332328204844776 no 1685 0.319124003795069 1058 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS Transcription elongation factor that contains a conserved zinc finger domain; implicated in the maintenance of proper chromatin structure in actively transcribed regions; deletion inhibits Brome mosaic virus (BMV) gene expression regulation of transcription by chromatin organization|transcription elongation from RNA polymerase II promoter RNA polymerase II core binding transcription elongation factor complex|nucleus
YIL166C_p YIL166C YIL166C hom Uncharacterized 0.433490117590355 0.332329371987608 no 1686 0.331767991083525 1103 NA Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; YIL166C is a non-essential gene transport transporter activity integral to membrane|membrane
YOL073C YOL073C YOL073C hom Verified 0.433268096429647 0.332410006393921 no 1687 0.331947785507002 1129 NA Subunit of the DSC ubiquitin ligase complex; ortholog of fission yeast dsc2 biological_process molecular_function integral to membrane
YNL215W YNL215W IES2 hom Verified 0.433176945835031 0.332443113025585 no 1688 0.342630917210514 1129 NA FT NUCLEUS Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus
YFR034C YFR034C PHO4 hom Verified 0.432672900853963 0.332626209825781 no 1689 0.358871535860021 1191 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS NUCLEUS Basic helix-loop-helix (bHLH) transcription factor of the myc-family; activates transcription cooperatively with Pho2p in response to phosphate limitation; binding to 'CACGTG' motif is regulated by chromatin restriction, competitive binding of Cbf1p to the same DNA binding motif and cooperation with Pho2p,; function is regulated by phosphorylation at multiple sites and by phosphate availability cellular response to phosphate starvation|positive regulation of phosphate metabolic process|phosphate-containing compound metabolic process|chromatin remodeling|positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nucleus|cytoplasm
YIR033W YIR033W MGA2 hom Verified 0.431849655489188 0.33292534358493 no 1690 0.270351678190142 921 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|GENE SILENCING ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting positive regulation of transcription from RNA polymerase II promoter in response to hypoxia|cellular response to cold|positive regulation of unsaturated fatty acid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|mRNA stabilization|positive regulation of transcription from RNA polymerase II promoter in response to cobalt ion|positive regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette molecular_function integral to endoplasmic reticulum membrane|nucleus
YER185W YER185W PUG1 hom Verified 0.431833830591553 0.332931094749227 no 1691 0.31830662124264 1050 NA FT PLASMA MEMBRANE Plasma membrane protein with roles in the uptake of protoprophyrin IX and the efflux of heme; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of proteins heme transport molecular_function integral to membrane|plasma membrane
YNR004W_p YNR004W SWM2 hom Uncharacterized 0.431833156858043 0.332931339601737 no 1692 0.322044908291776 1101 NA FT NUCLEUS Putative protein of unknown function; haploid disruptant exhibits cold-sensitive growth and elongated buds biological_process molecular_function nucleolus
YDR509W_d YDR509W YDR509W hom Dubious 0.429657084771591 0.333722552721232 no 1693 0.322782621149127 1120 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR435W YLR435W TSR2 hom Verified 0.428108371761897 0.334286110991915 no 1694 0.346881105869388 1175 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Protein with a potential role in pre-rRNA processing maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function nucleus|cytoplasm
YNR044W YNR044W AGA1 hom Verified 0.426229405286704 0.334970346298741 no 1695 0.297402388004097 1029 NA Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds agglutination involved in conjugation with cellular fusion cell adhesion molecule binding fungal-type cell wall
YKR061W YKR061W KTR2 hom Verified 0.425674226484559 0.335172622522863 no 1696 0.323342159462891 1091 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Mannosyltransferase involved in N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR2 has a paralog, YUR1, that arose from the whole genome duplication cell wall mannoprotein biosynthetic process|protein N-linked glycosylation mannosyltransferase activity Golgi apparatus
YCR076C YCR076C FUB1 hom Verified 0.424698838756211 0.335528115218609 no 1697 0.37942449489082 1229 NA Putative protein of unknown function; interacts physically with multiple subunits of the 20S proteasome and genetically with genes encoding 20S core particle and 19S regulatory particle subunits; exhibits boundary activity which blocks the propagation of heterochromatic silencing; contains a PI31 proteasome regulator domain and sequence similarity with human PSMF1, a proteasome inhibitor; not an essential gene biological_process proteasome binding cellular_component
YOR225W_d YOR225W YOR225W hom Dubious 0.424301147498219 0.335673101236563 no 1698 0.342031331572386 1182 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YJR008W YJR008W MHO1 hom Verified 0.423798796678658 0.335856277886624 no 1699 0.33101746505696 1119 NA FT NUCLEUS Protein of unknown function; inhibits haploid invasive growth when overexpressed; synthetically lethal with phospholipase C (PLC1); expression induced by mild heat-stress on a non-fermentable carbon source, upon entry into stationary phase and upon nitrogen deprivation; repressed by inosine and choline in an Opi1p-dependent manner; highly conserved from bacteria to human; Memo, the human homolog, is an ErbB2 interacting protein with an essential function in cell motility biological_process molecular_function nucleus|cytoplasm
YJR079W_p YJR079W YJR079W hom Uncharacterized 0.422466949286521 0.336342109925958 no 1700 0.355447493153126 1197 NA Putative protein of unknown function; mutation results in impaired mitochondrial respiration biological_process molecular_function cellular_component
YHR162W YHR162W MPC2 hom Verified 0.421880734023561 0.336556036564094 no 1701 0.326883547649323 1104 NA Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; more highly expressed in glucose-containing minimal medium than in lactate-containing medium mitochondrial pyruvate transport pyruvate transmembrane transporter activity mitochondrion|integral to mitochondrial inner membrane
YFL049W YFL049W SWP82 hom Verified 0.421295715551663 0.336769579210577 no 1702 0.325557511718178 1081 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS RSC COMPLEX Member of the SWI/SNF chromatin remodeling complex; has an as yet unidentified role in the complex; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p; relocates to the cytosol under hypoxic conditions positive regulation of transcription from RNA polymerase II promoter molecular_function SWI/SNF complex|nucleus
YOR246C YOR246C ENV9 hom Verified 0.421038697342494 0.336863412293649 no 1703 0.343704576219686 1157 NA FF|FT OXIDATION-REDUCTION PROCESS|VACUOLAR PROTEIN PROCESSING Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts vacuole organization|vacuolar protein processing oxidoreductase activity lipid particle
YOL014W_p YOL014W YOL014W hom Uncharacterized 0.420987627781248 0.336882058152475 no 1704 0.363091847716472 1226 NA Putative protein of unknown function biological_process molecular_function cellular_component
YNR019W YNR019W ARE2 hom Verified 0.420334230412713 0.337120653525033 no 1705 0.339959573315248 1135 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen; ARE2 has a paralog, ARE1, that arose from the whole genome duplication ergosterol metabolic process ergosterol O-acyltransferase activity integral to membrane|endoplasmic reticulum
YOR080W YOR080W DIA2 hom Verified 0.420262420340174 0.337146879776611 no 1706 0.344419909593233 1167 NA FT CELL CYCLE|PROTEOLYSIS NUCLEUS|CHROMOSOME UBIQUITIN LIGASE COMPLEX Origin-binding F-box protein; forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays a role in DNA replication; plays a role in transcription; required for correct assembly of RSC complex, correct RSC-mediated transcription regulation, and correct nucleosome positioning; involved in invasive and pseudohyphal growth; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|regulation of DNA replication|invasive growth in response to glucose limitation|protein ubiquitination ubiquitin-protein ligase activity|DNA replication origin binding SCF ubiquitin ligase complex|nucleus|nuclear replication fork
YGL094C YGL094C PAN2 hom Verified 0.41939306209528 0.337464446854389 no 1707 0.348325936504779 1206 NA FT RNA PROCESSING|RESPONSE TO DNA DAMAGE|PROTEOLYSIS Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes mRNA 3'-end processing|postreplication repair|mRNA processing poly(A)-specific ribonuclease activity PAN complex|cytoplasm
YDR244W YDR244W PEX5 hom Verified 0.418329001828294 0.337853294051144 no 1708 0.35317551134047 1184 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PEROXISOME ORGANIZATION Peroxisomal membrane signal receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions protein import into peroxisome matrix, docking peroxisome matrix targeting signal-1 binding|protein binding, bridging cytosol|peroxisomal membrane|peroxisome
YER063W YER063W THO1 hom Verified 0.417341655859169 0.33821426185062 no 1709 0.309508247130238 1020 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA LOCALIZATION NUCLEUS Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation poly(A)+ mRNA export from nucleus|transcription, DNA-dependent|ribonucleoprotein complex assembly chromatin binding|double-stranded DNA binding|RNA binding nucleus
YER072W YER072W VTC1 hom Verified 0.416105567876706 0.338666377924983 no 1710 0.341810003982694 1125 NA FT MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT ENDOPLASMIC RETICULUM Subunit of the vacuolar transporter chaperone (VTC) complex; VTC complex is involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; also has mRNA binding activity; protein abundance increases in response to DNA replication stress polyphosphate metabolic process|vacuolar transport|microautophagy|vacuole fusion, non-autophagic mRNA binding integral to membrane|endoplasmic reticulum|vacuolar transporter chaperone complex|intrinsic to vacuolar membrane
YMR313C YMR313C TGL3 hom Verified 0.414571482232521 0.339227814129446 no 1711 0.336175609871852 1168 NA FT LIPID METABOLISM|CELL DIVISION Bifunctional enzyme with triacylglycerol lipase and lysophosphatidylethanolamine acyltransferase activity; responsible for all the triacylglycerol lipase activity of the lipid particle; required with Tgl4p for timely bud formation triglyceride catabolic process|cell budding|cellular lipid metabolic process triglyceride lipase activity|lysophosphatidylethanolamine acyltransferase activity lipid particle
YBR288C YBR288C APM3 hom Verified 0.414261918628559 0.339341149855305 no 1712 0.354959229114013 1196 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway Golgi to vacuole transport|vesicle-mediated transport molecular_function AP-3 adaptor complex
YNL063W YNL063W MTQ1 hom Verified 0.414169748888994 0.339374897342478 no 1713 0.349294244050705 1178 NA FT TRANSLATION MITOCHONDRION S-adenosylmethionine-dependent methyltransferase; methylates translational release factor Mrf1p; similar to E.coli PrmC; is not an essential gene translational readthrough S-adenosylmethionine-dependent methyltransferase activity mitochondrion
YLL016W YLL016W SDC25 hom pseudogene 0.41395554020246 0.339453333752962 no 1714 0.339300106453285 1157 NA FT SIGNALING Non-essential Ras guanine nucleotide exchange factor (GEF); localized to the membrane; expressed in poor nutrient conditions and on nonfermentable carbon sources; contains a stop codon in S288C, full-length gene includes YLL017W; SDC25 has a paralog, CDC25, that arose from the whole genome duplication Ras protein signal transduction Ras guanyl-nucleotide exchange factor activity cellular_component
YBR118W YBR118W TEF2 hom Verified 0.413798301211526 0.339510914099087 no 1715 0.321271870991626 1069 NA FT TRANSLATION|NUCLEOTIDE METABOLISM|RNA LOCALIZATION CYTOSKELETON RIBOSOME Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus; TEF2 has a paralog, TEF1, that arose from the whole genome duplication translational elongation|tRNA export from nucleus GDP binding|GTP binding|translation elongation factor activity ribosome|eukaryotic translation elongation factor 1 complex|cytoplasm
YML081W YML081W TDA9 hom Verified 0.412307930126523 0.340056868452325 no 1716 0.321651228701039 1084 NA FT NUCLEUS DNA-binding protein, putative transcription factor; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; TDA9 has a paralog, RSF2, that arose from the whole genome duplication biological_process sequence-specific DNA binding nucleus
YER175C YER175C TMT1 hom Verified 0.411797620588943 0.340243882772236 no 1717 0.288538297167421 955 NA Trans-aconitate methyltransferase, cytosolic enzyme that catalyzes the methyl esterification of 3-isopropylmalate, an intermediate of the leucine biosynthetic pathway, and trans-aconitate, which inhibits the citric acid cycle biological_process trans-aconitate 3-methyltransferase activity cytosol
YDR223W YDR223W CRF1 hom Verified 0.410995752504631 0.340537824616346 no 1718 0.340124990135444 1119 NA FT TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS NUCLEUS|CHROMOSOME Transcriptional corepressor involved in repression of ribosomal protein (RP) gene transcription via the TOR signaling pathway which promotes accumulation of Crf1p in the nucleus; role in repression of RP genes varies by strain negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter transcription corepressor activity nuclear chromatin|nucleus|cytoplasm
YLR039C YLR039C RIC1 hom Verified 0.410431975068861 0.340744547273217 no 1719 0.422364090055858 1380 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes intracellular protein transport|retrograde transport, endosome to Golgi guanyl-nucleotide exchange factor activity nucleus|Ric1p-Rgp1p complex|Golgi membrane|guanyl-nucleotide exchange factor complex
YOL082W YOL082W ATG19 hom Verified 0.409410536470279 0.341119204301428 no 1720 0.317496612796015 1065 NA FT PROTEIN LOCALIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; delivers cargo proteins aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p) to the phagophore assembly site for packaging into Cvt vesicles vesicle organization|ER-associated protein catabolic process|protein processing|protein complex localization|CVT pathway protein binding, bridging pre-autophagosomal structure|cytoplasm|CVT complex|extrinsic to membrane
YJR147W YJR147W HMS2 hom Verified 0.409231281380742 0.341184970074376 no 1721 0.328844585103097 1098 NA FT NUCLEUS Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant; HMS2 has a paralog, SKN7, that arose from the whole genome duplication pseudohyphal growth molecular_function nucleus|cytoplasm
YNL291C YNL291C MID1 hom Verified 0.408186813412975 0.341568264258545 no 1722 0.325277902610332 1067 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS ENDOPLASMIC RETICULUM|PLASMA MEMBRANE N-glycosylated integral membrane protein of the ER membrane and plasma membrane, functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone; interacts with Cch1p; forms an oligomer calcium ion transport stretch-activated, cation-selective, calcium channel activity|calcium channel activity endoplasmic reticulum|plasma membrane
YGR244C YGR244C LSC2 hom Verified 0.408111261012828 0.341595996483853 no 1723 0.345572913016568 1175 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Beta subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate tricarboxylic acid cycle|succinyl-CoA metabolic process succinate-CoA ligase (ADP-forming) activity mitochondrion
YJL028W YJL028W YJL028W hom Verified 0.406414879255143 0.342218894399862 no 1724 0.302909612918273 1036 NA Protein of unknown function; may interact with ribosomes, based on co-purification experiments biological_process molecular_function ribosome
YNR037C YNR037C RSM19 hom Verified 0.405512383770333 0.342550458743952 no 1725 0.358066502984732 1210 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S19 ribosomal protein mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YGL021W YGL021W ALK1 hom Verified 0.405184810263549 0.342670834746496 no 1726 0.348987807723854 1160 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; ALK1 has a paralog, ALK2, that arose from the whole genome duplication; similar to mammalian haspins mitosis|protein phosphorylation protein serine/threonine kinase activity|protein kinase activity cellular_component
YDR100W YDR100W TVP15 hom Verified 0.403342056537617 0.34334830334909 no 1727 0.348480554386237 1174 NA FT VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p vesicle-mediated transport molecular_function COPI-coated vesicle|integral to membrane|integral to Golgi membrane
YIL046W-A_p YIL046W-A YIL046W-A hom Uncharacterized 0.402908932489273 0.343507609933721 no 1728 0.33894093563855 1142 NA Putative protein of unknown function; identified by expression profiling and mass spectrometry biological_process molecular_function cellular_component
YBL082C YBL082C ALG3 hom Verified 0.402603925490775 0.343619810699169 no 1729 0.331824804254187 1109 NA FT LIPID METABOLISM|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins oligosaccharide-lipid intermediate biosynthetic process|protein glycosylation alpha-1,3-mannosyltransferase activity integral to membrane|endoplasmic reticulum
YLR343W YLR343W GAS2 hom Verified 0.402291076141019 0.343734910689521 no 1730 0.304593663278702 1025 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM PLASMA MEMBRANE 1,3-beta-glucanosyltransferase, involved with Gas4p in spore wall assembly; has similarity to Gas1p ascospore wall assembly 1,3-beta-glucanosyltransferase activity integral to membrane|cytoplasm
YLR052W YLR052W IES3 hom Verified 0.402195698508647 0.343770003830042 no 1731 0.334951034878883 1122 NA FT CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Subunit of the INO80 chromatin remodeling complex nucleosome mobilization|telomere maintenance|chromatin silencing at telomere molecular_function nucleus|Ino80 complex
YAR027W YAR027W UIP3 hom Verified 0.401017682721345 0.34420355256729 no 1732 0.341477396421647 1165 NA FT ENDOMEMBRANE SYSTEM|NUCLEUS|PLASMA MEMBRANE Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family biological_process molecular_function nuclear envelope
YPL116W YPL116W HOS3 hom Verified 0.39885303250288 0.34500074908735 no 1733 0.330390824299057 1118 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION NUCLEUS|SITE OF POLARIZED GROWTH Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) with specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats regulation of transcription involved in G1/S phase of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|histone deacetylation histone deacetylase activity nucleus|cellular bud neck|cytoplasm
YDL149W YDL149W ATG9 hom Verified 0.397962919498263 0.345328759517625 no 1734 0.333482663943424 1086 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS ENDOMEMBRANE SYSTEM|MITOCHONDRION Transmembrane protein involved in forming Cvt and autophagic vesicles; cycles between the phagophore assembly site (PAS) and other cytosolic punctate structures, not found in autophagosomes; may be involved in membrane delivery to the PAS piecemeal microautophagy of nucleus|mitochondrion degradation|protein homooligomerization|CVT pathway|autophagic vacuole assembly molecular_function mitochondrion|integral to membrane|pre-autophagosomal structure
YPR027C_p YPR027C YPR027C hom Uncharacterized 0.396909438774836 0.345717121793631 no 1735 0.354286248701358 1229 NA Putative protein of unknown function biological_process molecular_function cellular_component
YNR001C YNR001C CIT1 hom Verified 0.396460675952449 0.345882606114986 no 1736 0.356439370061836 1202 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein; CIT1 has a paralog, CIT2, that arose from the whole genome duplication glutamate biosynthetic process|tricarboxylic acid cycle|acetyl-CoA catabolic process|citrate metabolic process citrate (Si)-synthase activity mitochondrion
YBR176W YBR176W ECM31 hom Verified 0.396390205804051 0.345908595133779 no 1737 0.356630763722487 1174 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM MITOCHONDRION Ketopantoate hydroxymethyltransferase, required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate pantothenate biosynthetic process 3-methyl-2-oxobutanoate hydroxymethyltransferase activity mitochondrion
YJL117W YJL117W PHO86 hom Verified 0.394902597577679 0.34645738644471 no 1738 0.322880365861985 1105 NA FT VESICLE-MEDIATED TRANSPORT|ION HOMEOSTASIS|ION HOMEOSTASIS ENDOPLASMIC RETICULUM Endoplasmic reticulum (ER) resident protein; required for ER exit of the high-affinity phosphate transporter Pho84p, specifically required for packaging of Pho84p into COPII vesicles; protein abundance increases in response to DNA replication stress protein folding|ER to Golgi vesicle-mediated transport|regulation of phosphate transport unfolded protein binding endoplasmic reticulum
YNL031C YNL031C HHT2 hom Verified 0.393992435947807 0.346793311879441 no 1739 0.335317211300802 1093 NA FT CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT1); regulated by acetylation, methylation, and phosphorylation chromatin assembly or disassembly|global genome nucleotide-excision repair|rRNA transcription|sexual sporulation resulting in formation of a cellular spore|mitotic cell cycle spindle assembly checkpoint DNA binding nuclear nucleosome
YDL013W YDL013W SLX5 hom Verified 0.392670580395304 0.34728140114857 no 1740 0.403521757488583 1339 NA FT RESPONSE TO DNA DAMAGE NUCLEUS UBIQUITIN LIGASE COMPLEX Subunit of the Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex, stimulated by SUMO-modified substrates; contains a RING domain and two SIMs (SUMO-interacting motifs); forms SUMO-dependent nuclear foci, including DNA repair centers protein sumoylation|telomere maintenance|response to DNA damage stimulus|protein ubiquitination SUMO binding|ubiquitin-protein ligase activity ubiquitin ligase complex|nucleus
YNR073C_p YNR073C YNR073C hom Uncharacterized 0.392396534936606 0.347382622950474 no 1741 0.384796193180656 1295 NA Putative mannitol dehydrogenase; identical in amino acid sequence to Dsf1p biological_process mannitol dehydrogenase activity cellular_component
YNL005C YNL005C MRP7 hom Verified 0.392377327942561 0.347389717680089 no 1742 0.384672886217358 1262 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome|peptidyltransferase activity mitochondrion|mitochondrial large ribosomal subunit
YKL155C YKL155C RSM22 hom Verified 0.391400337310547 0.347750671514645 no 1743 0.34823168527995 1167 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase mitochondrial translation structural constituent of ribosome|S-adenosylmethionine-dependent methyltransferase activity mitochondrion|mitochondrial small ribosomal subunit
YBR084W YBR084W MIS1 hom Verified 0.391192751312343 0.347827382941272 no 1744 0.332073261771094 1114 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM MITOCHONDRION Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase nucleobase-containing compound metabolic process|folic acid biosynthetic process formate-tetrahydrofolate ligase activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|methenyltetrahydrofolate cyclohydrolase activity mitochondrion
YGL067W YGL067W NPY1 hom Verified 0.390418829573606 0.348113433226678 no 1745 0.307067070454549 1026 NA FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes; nudix hydrolase family member NADH metabolic process NAD+ diphosphatase activity peroxisome|cytoplasm
YBR178W_d YBR178W YBR178W hom Dubious 0.38961825290476 0.348409426437292 no 1746 0.354407928437727 1205 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR177C Unknown Unknown Unknown
YML004C YML004C GLO1 hom Verified 0.389575088460621 0.348425388036497 no 1747 0.351490981145603 1161 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Monomeric glyoxalase I, catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione; expression regulated by methylglyoxal levels and osmotic stress methylglyoxal catabolic process to D-lactate|glutathione metabolic process lactoylglutathione lyase activity nucleus|cytoplasm
YDR184C YDR184C ATC1 hom Verified 0.389537319764766 0.348439354584698 no 1748 0.365662183043526 1210 NA FT CELL CYCLE|CELL DIVISION NUCLEUS Nuclear protein; possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding pattern; relative distribution to the nucleus decreases upon DNA replication stress bipolar cellular bud site selection|response to stress molecular_function nucleus
YLL029W YLL029W FRA1 hom Verified 0.389271016656434 0.348537837080641 no 1749 0.355915449061388 1188 NA FT TRANSCRIPTION FROM RNA POL II|PROTEOLYSIS Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; cytosolic; mutant fails to repress transcription of iron regulon and is defective in spore formation negative regulation of transcription from RNA polymerase II promoter in response to iron molecular_function cytosol|cytoplasm
YER026C YER026C CHO1 hom Verified 0.388790462145123 0.348715578477906 no 1750 0.361980815852492 1212 NA FT LIPID METABOLISM ENDOPLASMIC RETICULUM|MITOCHONDRION Phosphatidylserine synthase, functions in phospholipid biosynthesis; catalyzes the reaction CDP-diaclyglycerol + L-serine = CMP + L-1-phosphatidylserine, transcriptionally repressed by myo-inositol and choline phosphatidylserine biosynthetic process CDP-diacylglycerol-serine O-phosphatidyltransferase activity mitochondrial outer membrane|integral to membrane|endoplasmic reticulum
YGR219W_d YGR219W YGR219W hom Dubious 0.38819762954236 0.348934893622737 no 1751 0.365295785045493 1203 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRPL9/YGR220C Unknown Unknown Unknown
YLR152C_p YLR152C YLR152C hom Uncharacterized 0.388181759826922 0.348940765230263 no 1752 0.345328119320404 1176 NA Putative protein of unknown function; YLR152C is not an essential gene biological_process molecular_function integral to membrane
YGR263C YGR263C SAY1 hom Verified 0.388160089144624 0.348948783185523 no 1753 0.363195033645022 1224 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Sterol deacetylase; component of the sterol acetylation/deacetylation cycle along with Atf2p; integral membrane protein with active site in the ER lumen; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum response to toxin|sterol metabolic process|sterol deacetylation steryl deacetylase activity integral to membrane|endoplasmic reticulum|endoplasmic reticulum lumen
YDR191W YDR191W HST4 hom Verified 0.387761974640702 0.349096093926852 no 1754 0.349817161090069 1185 NA FT KETONE METABOLISM|LIPID METABOLISM|CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism short-chain fatty acid metabolic process|chromatin silencing at telomere|histone deacetylation histone deacetylase activity|DNA binding nucleus|cytoplasm
YJL182C_d YJL182C YJL182C hom Dubious 0.387594113594841 0.349158212862358 no 1755 0.350611289083571 1204 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YJL181W Unknown Unknown Unknown
YJR125C YJR125C ENT3 hom Verified 0.387545611617388 0.349176162336825 no 1756 0.343166219924656 1130 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS|CYTOSKELETON Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p late endosome to vacuole transport via multivesicular body sorting pathway|early endosome to Golgi transport|actin filament organization|endocytosis|actin cortical patch assembly|Golgi to endosome transport protein binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding clathrin vesicle coat|actin cortical patch
YDR161W_p YDR161W YDR161W hom Uncharacterized 0.387271149214479 0.349277740961237 no 1757 0.353277284524984 1194 NA FT PROTEOLYSIS NUCLEUS Putative protein of unknown function; non-essential gene; proposed function in rRNA and ribosome biosynthesis based on transcriptional co-regulation; genetic interactions suggest a role in ER-associated protein degradation (ERAD) ER-associated protein catabolic process molecular_function nucleus|cytoplasm
YDL168W YDL168W SFA1 hom Verified 0.386951947409179 0.349395891233619 no 1758 0.38001042168646 1252 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION Bifunctional alcohol dehydrogenase and formaldehyde dehydrogenase; formaldehyde dehydrogenase activity is glutathione-dependent; functions in formaldehyde detoxification and formation of long chain and complex alcohols, regulated by Hog1p-Sko1p; protein abundance increases in response to DNA replication stress furaldehyde metabolic process|formaldehyde catabolic process|amino acid catabolic process to alcohol via Ehrlich pathway S-(hydroxymethyl)glutathione dehydrogenase activity|hydroxymethylfurfural reductase (NADH) activity|alcohol dehydrogenase (NAD) activity mitochondrion|cytoplasm
YGL139W YGL139W FLC3 hom Verified 0.385951377333359 0.34976633963963 no 1759 0.341208596083938 1124 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER FAD transport|transmembrane transport FAD transmembrane transporter activity mitochondrion|integral to membrane|endoplasmic reticulum
YAL066W_d YAL066W YAL066W hom Dubious 0.385243531234315 0.35002849713394 no 1760 0.367164325867518 1207 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGR018C_p YGR018C YGR018C hom Uncharacterized 0.384577281913286 0.350275314189607 no 1761 0.334779892676456 1107 NA Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the uncharacterized ORF YGR017W biological_process molecular_function cellular_component
YHR129C YHR129C ARP1 hom Verified 0.383512277264861 0.350669984465997 no 1762 0.35028099113314 1172 NA FT CELL CYCLE|CYTOSKELETON ORGANIZATION CYTOSKELETON Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; putative ortholog of mammalian centractin nuclear migration|establishment of mitotic spindle orientation structural constituent of cytoskeleton cell cortex|dynactin complex|spindle pole body|astral microtubule
YGL121C YGL121C GPG1 hom Verified 0.381830019091278 0.35129372538179 no 1763 0.330111981731692 1110 NA FT SIGNALING Proposed gamma subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p; involved in regulation of pseudohyphal growth; requires Gpb1p or Gpb2p to interact with Gpa2p; overproduction causes prion curing signal transduction|invasive growth in response to glucose limitation signal transducer activity cellular_component
YDR452W YDR452W PPN1 hom Verified 0.381441012326283 0.351438016853392 no 1764 0.397567551565045 1298 NA FT NUCLEUS Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress polyphosphate catabolic process|polyphosphate metabolic process endopolyphosphatase activity|exopolyphosphatase activity fungal-type vacuole membrane|nucleus
YHR202W_p YHR202W YHR202W hom Uncharacterized 0.38100438272176 0.351599998224627 no 1765 0.352511592417419 1191 NA FT NUCLEOTIDE METABOLISM Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization biological_process molecular_function cytosol|fungal-type vacuole
YER170W YER170W ADK2 hom Verified 0.379040297119333 0.352328969926539 no 1766 0.350191956137063 1185 NA FT NUCLEOTIDE METABOLISM MITOCHONDRION Mitochondrial adenylate kinase, catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background nucleotide metabolic process nucleoside triphosphate adenylate kinase activity|adenylate kinase activity mitochondrion|mitochondrial inner membrane
YER052C YER052C HOM3 hom Verified 0.378413276564712 0.35256180346844 no 1767 0.35579426459501 1177 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis threonine biosynthetic process|methionine biosynthetic process|homoserine biosynthetic process aspartate kinase activity cytoplasm
YOR301W YOR301W RAX1 hom Verified 0.378086804214162 0.352683055365702 no 1768 0.322289011848274 1078 NA FT CELL CYCLE|SIGNALING|CELL DIVISION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily cellular bud site selection molecular_function integral to membrane|cellular bud neck
YER049W YER049W TPA1 hom Verified 0.376961824388044 0.353100987683291 no 1769 0.345107338034851 1129 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|OXIDATION-REDUCTION PROCESS NUCLEUS Poly(rA)-binding protein involved in translation termination efficiency, mRNA poly(A) tail length and mRNA stability; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; similar to prolyl 4-hydroxylases; binds Fe(III) and 2-oxoglutarate nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|translational termination poly(A) RNA binding nucleus
YML003W_p YML003W YML003W hom Uncharacterized 0.376872145814231 0.3531343110927 no 1770 0.337508482354521 1125 NA Putative protein of unknown function biological_process molecular_function cellular_component
YJL047C-A_p YJL047C-A YJL047C-A hom Uncharacterized 0.37549847106323 0.353644891654132 no 1771 0.350120403273813 1149 NA Putative protein of unknown function biological_process molecular_function cellular_component
YKL043W YKL043W PHD1 hom Verified 0.374651910472846 0.353959680636883 no 1772 0.329961764868927 1078 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Transcriptional activator that enhances pseudohyphal growth; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate; PHD1 has a paralog, SOK2, that arose from the whole genome duplication pseudohyphal growth|positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nucleus
YOL075C_p YOL075C YOL075C hom Uncharacterized 0.374366567063481 0.354065806553205 no 1773 0.327453009046409 1101 NA FT NUCLEOTIDE METABOLISM Putative ABC transporter transport ATPase activity, coupled to transmembrane movement of substances integral to membrane|membrane
YOL012C YOL012C HTZ1 hom Verified 0.373863988649621 0.35425275483533 no 1774 0.371703739408879 1252 NA FF|FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin nuclear-transcribed mRNA catabolic process, non-stop decay|regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette chromatin binding nuclear chromatin|chromatin assembly complex
YDL192W YDL192W ARF1 hom Verified 0.372729621678623 0.354674843841882 no 1775 0.374367148439166 1232 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|RESPONSE TO NUTRIENT LEVELS GOLGI APPARATUS ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication ER to Golgi vesicle-mediated transport|Golgi to plasma membrane transport|intra-Golgi vesicle-mediated transport|macroautophagy GTPase activity cytosol|Golgi-associated vesicle
YNL140C_p YNL140C YNL140C hom Uncharacterized 0.372605758122335 0.354720943312655 no 1776 0.400135999007694 1335 NA Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps THO2/YNL139C biological_process molecular_function cellular_component
YGL158W YGL158W RCK1 hom Verified 0.371735735483857 0.355044807787181 no 1777 0.343021709982632 1138 NA FT CELL CYCLE|PROTEIN PHOSPHORYLATION Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations; RCK1 has a paralog, RCK2, that arose from the whole genome duplication protein phosphorylation|regulation of meiosis protein serine/threonine kinase activity|protein kinase activity cellular_component
YIL116W YIL116W HIS5 hom Verified 0.371247499647703 0.355226598665678 no 1778 0.357604747429145 1223 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Histidinol-phosphate aminotransferase, catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts histidine biosynthetic process histidinol-phosphate transaminase activity intracellular
YML094W YML094W GIM5 hom Verified 0.370519885471411 0.355497581376504 no 1779 0.337151399042196 1140 NA FT PROTEIN COMPLEX ORG/BIOGENESIS Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it tubulin complex assembly tubulin binding prefoldin complex|cytoplasm
YMR069W YMR069W NAT4 hom Verified 0.370337722403101 0.355565435148769 no 1780 0.373375337864464 1239 NA FT CHROMATIN ORGANIZATION NUCLEUS N alpha-acetyl-transferase, involved in acetylation of the N-terminal residues of histones H4 and H2A histone acetylation histone acetyltransferase activity nucleus|cytoplasm
YPR179C YPR179C HDA3 hom Verified 0.369230043711087 0.355978131955273 no 1781 0.355741987408951 1175 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|CHROMOSOME SEGREGATION|GENE SILENCING NUCLEUS|CHROMOSOME Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex that contains an Hda1p homodimer and an Hda2p-Hda3p heterodimer; required for the activity of the complex; has similarity to Hda2p negative regulation of transcription from RNA polymerase II promoter|chromosome segregation|gene silencing by RNA|gene silencing involved in chronological cell aging|histone deacetylation histone deacetylase activity|chromatin binding|DNA binding nucleus|HDA1 complex
YOL110W YOL110W SHR5 hom Verified 0.36914632358112 0.356009331108649 no 1782 0.356318186933726 1170 NA FT PROTEIN LOCALIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Subunit of a palmitoyltransferase, composed of Shr5p and Erf2p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; palmitoylation is required for Ras2p membrane localization protein targeting to membrane|protein palmitoylation palmitoyltransferase activity endoplasmic reticulum palmitoyltransferase complex|extrinsic to endoplasmic reticulum membrane
YBL037W YBL037W APL3 hom Verified 0.368553008310983 0.356230463665542 no 1783 0.353179751957314 1170 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|PLASMA MEMBRANE Alpha-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport vesicle-mediated transport molecular_function AP-2 adaptor complex
YLR414C YLR414C PUN1 hom Verified 0.368202450709628 0.3563611415529 no 1784 0.321004519395254 1044 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL WALL ORG/BIOGENESIS PLASMA MEMBRANE Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress fungal-type cell wall organization|protein oligomerization molecular_function integral to membrane|membrane raft|plasma membrane|cellular bud|cytoplasm
YGL017W YGL017W ATE1 hom Verified 0.367754520754127 0.356528141625551 no 1785 0.34317109500062 1159 NA FT PROTEOLYSIS Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway cellular protein modification process|protein arginylation arginyltransferase activity cytoplasm
YHR175W-A_p YHR175W-A YHR175W-A hom Uncharacterized 0.367749094945839 0.356530164678339 no 1786 0.343372588997973 1140 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YNR030W YNR030W ALG12 hom Verified 0.364879846489184 0.357600549422429 no 1787 0.387253735937994 1270 NA FT LIPID METABOLISM|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Alpha-1,6-mannosyltransferase localized to the ER; responsible for the addition of the alpha-1,6 mannose to dolichol-linked Man7GlcNAc2, acts in the dolichol pathway for N-glycosylation dolichol-linked oligosaccharide biosynthetic process|protein glycosylation alpha-1,6-mannosyltransferase activity integral to membrane|endoplasmic reticulum
YGR227W YGR227W DIE2 hom Verified 0.364234439503829 0.357841475848134 no 1788 0.356979064337835 1197 NA FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Dolichyl-phosphoglucose-dependent alpha-1,2 glucosyltransferase of the ER, functions in the pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation, has a role in regulation of ITR1 and INO1 dolichol-linked oligosaccharide biosynthetic process|protein N-linked glycosylation dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity integral to membrane|endoplasmic reticulum membrane
YGR131W YGR131W FHN1 hom Verified 0.362335372128345 0.358550714139158 no 1789 0.366565474742604 1225 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION PLASMA MEMBRANE Protein of unknown function; induced by ketoconazole; promoter region contains sterol regulatory element motif, which has been identified as a Upc2p-binding site; overexpression complements function of Nce102p in NCE102 deletion strain establishment of protein localization to plasma membrane molecular_function integral to membrane|membrane raft
YLR367W YLR367W RPS22B hom Verified 0.361682787411132 0.358794545570171 no 1790 0.350205470615752 1174 NA FT TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic small ribosomal subunit
YLR448W YLR448W RPL6B hom Verified 0.360844636984933 0.35910779610372 no 1791 0.362972768619104 1228 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal 60S subunit protein L6B; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6B has a paralog, RPL6A, that arose from the whole genome duplication cytoplasmic translation|ribosomal large subunit assembly structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YOL158C YOL158C ENB1 hom Verified 0.360574288037837 0.359208856601678 no 1792 0.338874495735339 1124 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Endosomal ferric enterobactin transporter, expressed under conditions of iron deprivation; member of the major facilitator superfamily; expression is regulated by Rcs1p and affected by chloroquine treatment ferric-enterobactin transport ferric-enterobactin transmembrane transporter activity integral to membrane|cellular bud membrane|plasma membrane
YFL010C YFL010C WWM1 hom Verified 0.360472598020169 0.359246872408167 no 1793 0.353426586037627 1182 NA FT NUCLEUS|MITOCHONDRION WW domain containing protein of unknown function; binds to Mca1p, a caspase-related protease that regulates H2O2-induced apoptosis; overexpression causes G1 phase growth arrest and clonal death that is suppressed by overexpression of MCA1 biological_process molecular_function mitochondrion|nucleus|cytoplasm
YPL035C_d YPL035C YPL035C hom Dubious 0.359931819437434 0.359449060530284 no 1794 0.36395329119725 1216 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene Unknown Unknown Unknown
YNL108C_p YNL108C YNL108C hom Uncharacterized 0.357492093236713 0.360361722176274 no 1795 0.373198725898118 1240 NA FT NUCLEUS Putative protein of unknown function; similar to prokaryotic phosphotransfer enzymes; null mutant shows alterations in glucose metabolism; GFP-fusion protein localizes to the cytoplasm and nucleus; YNL108C has a paralog, TFC7, that arose from the whole genome duplication biological_process molecular_function nucleus|cytoplasm
YPR139C YPR139C LOA1 hom Verified 0.356507130817522 0.360730406415471 no 1796 0.38788439592075 1292 NA FT PROTEIN LOCALIZATION|VACUOLAR TRANSPORT ENDOPLASMIC RETICULUM Lysophosphatidic acid acyltransferase; involved in triacelglyceride homeostasis and lipid droplet formation; localized to lipid droplets and the ER; specificity for oleoyl-CoA lipid particle organization|cellular triglyceride homeostasis|protein targeting to vacuole lysophosphatidic acid acyltransferase activity endoplasmic reticulum|lipid particle|cytoplasm
YDR269C_d YDR269C YDR269C hom Dubious 0.35589645617196 0.360959054921622 no 1797 0.352950448385412 1153 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YNL242W YNL242W ATG2 hom Verified 0.355583041047997 0.361076422964752 no 1798 0.35460909534222 1189 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION Peripheral membrane protein required for autophagic vesicle formation; also required for vesicle formation during pexophagy and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria; forms cytoplasmic foci upon DNA replication stress mitochondrion degradation|piecemeal microautophagy of nucleus|peroxisome degradation|CVT pathway|autophagic vacuole assembly molecular_function pre-autophagosomal structure|cytoplasm|extrinsic to membrane
YIL119C YIL119C RPI1 hom Verified 0.35512684329848 0.361247283778178 no 1799 0.342645065725216 1145 NA FT SIGNALING NUCLEUS Transcription factor with allelic differences between S288C and Sigma1278b; mediates fermentation stress tolerance by modulating cell wall integrity; overexpression suppresses heat shock sensitivity of wild-type RAS2 overexpression and also suppresses cell lysis defect of mpk1 mutation; allele from S288c can confer fMAPK pathway independent transcription of FLO11; S288C and Sigma1278b alleles differ in number of tandem repeats within ORF fungal-type cell wall biogenesis|Ras protein signal transduction|positive regulation of transcription from RNA polymerase II promoter small GTPase regulator activity nucleus
YBR259W YBR259W YBR259W hom Verified 0.355107798272429 0.361254417358653 no 1800 0.362576405319079 1181 NA Protein of unknown function; YBR259W is not an essential gene; forms cytoplasmic foci upon DNA replication stress biological_process molecular_function cellular_component
YHL041W_d YHL041W YHL041W hom Dubious 0.354901821455487 0.361331571933958 no 1801 0.330533904969382 1132 NA Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data Unknown Unknown Unknown
YER141W YER141W COX15 hom Verified 0.353734476866818 0.361768941098145 no 1802 0.346683186652529 1151 NA FT OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM MITOCHONDRION Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase heme a biosynthetic process oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor mitochondrion|integral to membrane|mitochondrial inner membrane
YGR125W_p YGR125W YGR125W hom Uncharacterized 0.353043862631572 0.362027778712733 no 1803 0.35816268795746 1215 NA Putative protein of unknown function; deletion mutant has decreased rapamycin resistance but normal wormannin resistance; green fluorescent protein (GFP)-fusion protein localizes to the vacuole biological_process molecular_function integral to membrane|fungal-type vacuole
YLR354C YLR354C TAL1 hom Verified 0.352090589287256 0.362385162878164 no 1804 0.387963011915652 1301 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS NUCLEUS Transaldolase, enzyme in the non-oxidative pentose phosphate pathway; converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate pentose-phosphate shunt sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity nucleus|cytoplasm
YJL146W YJL146W IDS2 hom Verified 0.350046478137358 0.363151908493855 no 1805 0.350603704301759 1159 NA FT CELL CYCLE NUCLEUS Protein involved in modulation of Ime2p activity during meiosis, appears to act indirectly to promote Ime2p-mediated late meiotic functions; found in growing cells and degraded during sporulation meiosis molecular_function nucleus|cytoplasm
YKL003C YKL003C MRP17 hom Verified 0.349915864328373 0.363200920387802 no 1806 0.368600098127954 1253 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YBR053C_p YBR053C YBR053C hom Uncharacterized 0.34964904829157 0.363301048150853 no 1807 0.348453998036351 1154 NA Putative protein of unknown function; induced by cell wall perturbation biological_process molecular_function cellular_component
YMR167W YMR167W MLH1 hom Verified 0.348443355707004 0.363753623482394 no 1808 0.345599642649734 1156 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION|CHROMOSOME Protein required for mismatch repair in mitosis and meiosis as well as crossing over during meiosis; forms a complex with Pms1p and Msh2p-Msh3p during mismatch repair; human homolog is associated with hereditary non-polyposis colon cancer mismatch repair|meiotic mismatch repair|reciprocal meiotic recombination|meiotic heteroduplex formation double-stranded DNA binding|DNA insertion or deletion binding|loop DNA binding|single-stranded DNA binding|dinucleotide insertion or deletion binding|ATPase activity|ATP binding mitochondrion|nucleus|MutLalpha complex|MutLbeta complex|cytoplasm
YOR327C YOR327C SNC2 hom Verified 0.348216773753348 0.363838695762871 no 1809 0.354192922503897 1158 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC2 has a paralog, SNC1, that arose from the whole genome duplication endocytosis|exocytosis|Golgi to plasma membrane transport|vesicle fusion SNAP receptor activity SNARE complex|trans-Golgi network|endosome|transport vesicle membrane
YMR086W YMR086W SEG1 hom Verified 0.348198068702128 0.363845719046547 no 1810 0.360528653048125 1212 NA Component of eisosome required for proper eisosome assembly; precedes Pil1p/Lsp1p during eisosome formation and controls eisosome length and shape; Seg1p-GFP diffusely distributed and forms heterogeneous patches at the plasma membrane in small buds, also found in medium and large buds; may interact with ribosomes, based on co-purification experiments; expression is repressed by cAMP; similar to A. gossypii SEG gene and to S. pombe Sle1p, important for generating eisosomes biological_process molecular_function eisosome|ribosome|cytoplasm
YER150W YER150W SPI1 hom Verified 0.34809718656859 0.363883598578864 no 1811 0.364019167771045 1208 NA GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p response to acid molecular_function fungal-type cell wall
YDR230W_d YDR230W YDR230W hom Dubious 0.347344877776103 0.364166119712164 no 1812 0.348021449474085 1182 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20 Unknown Unknown Unknown
YER046W-A_d YER046W-A YER046W-A hom Dubious 0.346504384401807 0.364481844895067 no 1813 0.359012987919279 1216 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOL016C YOL016C CMK2 hom Verified 0.346436826476722 0.364507226530693 no 1814 0.375729465261266 1227 NA FT SIGNALING|PROTEIN PHOSPHORYLATION Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK2 has a paralog, CMK1, that arose from the whole genome duplication signal transduction|protein phosphorylation protein kinase activity|calmodulin-dependent protein kinase activity cytoplasm
YBR007C YBR007C DSF2 hom Verified 0.346413788234836 0.36451588217601 no 1815 0.376101560141746 1274 NA FF Deletion suppressor of mpt5 mutation; relocalizes from bud neck to cytoplasm upon DNA replication stress biological_process molecular_function cellular_component
YMR044W YMR044W IOC4 hom Verified 0.346379826993408 0.364528641802544 no 1816 0.378157795780619 1244 NA FT CHROMATIN ORGANIZATION NUCLEUS Member of a complex (Isw1b) with Isw1p and Ioc2p; interacts directly with H3K36me3 nucleosomes through its PWWP domain to recruit the Isw1b complex to open reading frames in a Set2p-dependent manner; Isw1b exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing chromatin remodeling nucleosome binding|ATPase activity|DNA binding ISW1 complex
YDR063W YDR063W AIM7 hom Verified 0.346097701353676 0.364634645431149 no 1817 0.357985155429142 1202 NA FT CYTOSKELETON ORGANIZATION NUCLEUS|CYTOSKELETON Protein that interacts with Arp2/3 complex to stimulate actin filament debranching and inhibit actin nucleation; has similarity to Cof1p and also to human glia maturation factor (GMF); null mutant displays elevated mitochondrial genome loss actin filament debranching|negative regulation of Arp2/3 complex-mediated actin nucleation molecular_function nucleus|actin cortical patch|cytoplasm
YDL243C YDL243C AAD4 hom Verified 0.345445781130478 0.364879632296934 no 1818 0.363006734392015 1188 NA FT OXIDATION-REDUCTION PROCESS Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin cellular aldehyde metabolic process aryl-alcohol dehydrogenase (NAD+) activity cellular_component
YFL013C YFL013C IES1 hom Verified 0.344790883069963 0.365125793768775 no 1819 0.39803075988188 1307 NA FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Subunit of the INO80 chromatin remodeling complex nucleosome mobilization molecular_function nucleus|Ino80 complex
YMR247C YMR247C RKR1 hom Verified 0.344297253180582 0.365311374904359 no 1820 0.356084974783324 1183 NA FT CHROMATIN ORGANIZATION|PROTEOLYSIS|GENE SILENCING NUCLEUS RING domain E3 ubiquitin ligase; involved in the ubiquitin-mediated degradation of non-stop proteins; functional connections to chromatin modification; nuclear protein that also co-localizes with ribosomes; homolog of mouse Listerin, whose mutation has been reported to cause neurodegeneration in mice chromatin modification|chromatin silencing at telomere|ubiquitin-dependent protein catabolic process|protein ubiquitination ubiquitin-protein ligase activity|ribosome binding ribosome|nucleus
YLR344W YLR344W RPL26A hom Verified 0.344214428443782 0.365342516119732 no 1821 0.354154797219786 1148 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L26A; binds to 5.8S rRNA; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26A has a paralog, RPL26B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YGR118W YGR118W RPS23A hom Verified 0.342957822666633 0.365815095263684 no 1822 0.371033761234845 1247 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23A has a paralog, RPS23B, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|regulation of translational fidelity structural constituent of ribosome cytosolic small ribosomal subunit
YIL132C YIL132C CSM2 hom Verified 0.34117611619261 0.366485501144695 no 1823 0.338934465512118 1150 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function; structural analysis reveals a similar DNA-binding region in both Psy3p and Csm2p and that both regions work together to form a single DNA binding site; required for accurate chromosome segregation during meiosis meiotic chromosome segregation|recombinational repair|maintenance of rDNA|error-free translesion synthesis molecular_function nucleus|Shu complex|cytoplasm
YGL151W YGL151W NUT1 hom Verified 0.340705361556415 0.366662700992793 no 1824 0.366981077229451 1224 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS|MITOCHONDRION Component of the RNA polymerase II mediator complex, which is required for transcriptional activation and also has a role in basal transcription regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter molecular_function mitochondrion|mediator complex|nucleus
YJR105W YJR105W ADO1 hom Verified 0.340289515134801 0.366819256123519 no 1825 0.401497793779474 1315 NA FF|FT NUCLEOTIDE METABOLISM NUCLEUS Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle purine nucleobase metabolic process adenosine kinase activity nucleus|cytoplasm
YFR039C_p YFR039C YFR039C hom Uncharacterized 0.339175280973689 0.367238844832341 no 1826 0.347355438053545 1145 NA Putative protein of unknown function; may be involved in response to high salt and changes in carbon source; deletion mutant has decreased spore survival in Drosophila feces biological_process molecular_function cellular_component
YAL018C_p YAL018C YAL018C hom Uncharacterized 0.339133011373855 0.367254765479764 no 1827 0.374433938867139 1215 NA Putative protein of unknown function biological_process molecular_function integral to membrane
YBR077C YBR077C SLM4 hom Verified 0.337217174656765 0.367976595634707 no 1828 0.393454277017088 1262 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|SIGNALING Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4 signal transduction|microautophagy phosphatidylinositol-3,4-bisphosphate binding fungal-type vacuole membrane|EGO complex|late endosome membrane|cytoplasm
YOR152C_p YOR152C YOR152C hom Uncharacterized 0.335246634292447 0.36871952313074 no 1829 0.338361396676281 1153 NA Putative protein of unknown function; YOR152C is not an essential gene biological_process molecular_function membrane
YPR153W YPR153W YPR153W hom Verified 0.334629070466749 0.368952456441998 no 1830 0.357465098095217 1189 NA Putative protein of unknown function biological_process molecular_function integral to membrane
YIL002C YIL002C INP51 hom Verified 0.334044655699922 0.369172930895945 no 1831 0.399905667901544 1327 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION CYTOSKELETON Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in phosphatidylinositol 4,5-bisphosphate homeostasis and in endocytosis; null mutation confers cold-tolerant growth phosphatidylinositol dephosphorylation phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity membrane|cytoplasm
YPL267W YPL267W ACM1 hom Verified 0.334016791017512 0.369183444112953 no 1832 0.367937049424866 1219 NA FT CELL CYCLE|CELL DIVISION NUCLEUS Pseudosubstrate inhibitor of the anaphase-promoting complex/cyclosome (APC/C), that suppresses APC/C [Cdh1]-mediated proteolysis of mitotic cyclins; associates with Cdh1p, Bmh1p and Bmh2p; cell cycle regulated protein negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle ubiquitin-protein ligase inhibitor activity nucleus|cytoplasm
YNR070W_p YNR070W PDR18 hom Uncharacterized 0.333631636029393 0.369328771345855 no 1833 0.347685771341456 1174 NA FT NUCLEOTIDE METABOLISM MITOCHONDRION Putative transporter of the ATP-binding cassette (ABC) family, implicated in pleiotropic drug resistance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies transport ATPase activity, coupled to transmembrane movement of substances mitochondrion|integral to membrane|membrane
YIL093C YIL093C RSM25 hom Verified 0.332583063950199 0.369724514644691 no 1834 0.369385260874696 1245 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YNR067C YNR067C DSE4 hom Verified 0.331216395127559 0.370240518493236 no 1835 0.317855491924116 1079 NA FT CELL WALL ORG/BIOGENESIS|CELL DIVISION Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother cytokinesis, completion of separation glucan endo-1,3-beta-D-glucosidase activity fungal-type cell wall|extracellular region|cell septum
YNR069C YNR069C BSC5 hom Verified 0.331211123030145 0.370242509496101 no 1836 0.372732333396062 1247 NA Protein of unknown function; shows homology with N-terminal end of Bul1p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough expression includes YNR068C and the locus for this readthrough is termed BUL3; Bul3p is involved in ubiquitin-mediated sorting of plasma membrane proteins; readthrough and shortened forms of Bul3p interact with Rsp5p differently in vitro biological_process molecular_function cellular_component
YMR132C_p YMR132C JLP2 hom Uncharacterized 0.33057218792077 0.370483828495396 no 1837 0.355711310224089 1173 NA Protein of unknown function, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein) biological_process molecular_function cytoplasm
YML094C-A_d YML094C-A YML094C-A hom Dubious 0.329034252092761 0.3710648993614 no 1838 0.358471920847209 1222 NA FF Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene GIM5/YML094W; deletion confers sensitivity to GSAO Unknown Unknown Unknown
YPL212C YPL212C PUS1 hom Verified 0.327991437761612 0.37145906826495 no 1839 0.355802910631299 1185 NA FT RNA PROCESSING NUCLEUS tRNA:pseudouridine synthase, introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA; nuclear protein that appears to be involved in tRNA export; also acts on U2 snRNA snRNA pseudouridine synthesis|tRNA pseudouridine synthesis pseudouridine synthase activity nucleus
YOR345C_d YOR345C YOR345C hom Dubious 0.326792373469984 0.371912464057388 no 1840 0.363734304101474 1188 NA Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2 Unknown Unknown Unknown
YNR068C_p YNR068C YNR068C hom Uncharacterized 0.325684647978687 0.372331480316296 no 1841 0.365319379856983 1201 NA Putative protein of unknown function; exhibits homology to C-terminal end of Bul1p; expressed as a readthrough product of BSC5, the readthrough locus being termed BUL3; the BUL3 readthrough product is involved in ubiquitin-mediated sorting of plasma membrane proteins and interacts with WW domains of Rsp5p in vitro, but in a functionally different way than the non-readthrough form biological_process molecular_function cellular_component
YOR200W_d YOR200W YOR200W hom Dubious 0.325323210787469 0.37246823290065 no 1842 0.401551488952841 1341 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRM1/YOR201c Unknown Unknown Unknown
YOR255W YOR255W OSW1 hom Verified 0.324849682777391 0.372647420254097 no 1843 0.371466984810194 1236 NA FT CELL WALL ORG/BIOGENESIS Protein involved in sporulation; required for the construction of the outer spore wall layers; required for proper localization of Spo14p ascospore wall assembly|ascospore formation molecular_function prospore membrane
YOR023C YOR023C AHC1 hom Verified 0.32469291816797 0.372706747499114 no 1844 0.357286436006623 1213 NA FT CHROMATIN ORGANIZATION NUCLEUS HISTONE ACETYLTRANSFERASE Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex histone acetylation histone acetyltransferase activity Ada2/Gcn5/Ada3 transcription activator complex
YPL168W_p YPL168W YPL168W hom Uncharacterized 0.3245295016557 0.37276859535789 no 1845 0.376142653225945 1243 NA FT MITOCHONDRION Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; expression may be cell cycle-regulated biological_process molecular_function mitochondrion
YDR348C YDR348C PAL1 hom Verified 0.323550925355495 0.37313902338298 no 1846 0.379222964521884 1265 NA FT SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Protein of unknown function thought to be involved in endocytosis; Pal1p physically interacts with Ede1p and is found at endocytic sites at the cell periphery during the early stages of endocytosis; green fluorescent protein (GFP)-fusion protein also localizes to the bud neck; potential Cdc28p substrate; similar to the S. pombe Pal1 protein; relocalizes from bud neck to cytoplasm upon DNA replication stress biological_process molecular_function cell cortex|cellular bud neck|mating projection tip
YOL052C YOL052C SPE2 hom Verified 0.322980099042698 0.373355156854725 no 1847 0.38466892666322 1277 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM NUCLEUS S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically spermidine biosynthetic process|spermine biosynthetic process|pantothenate biosynthetic process adenosylmethionine decarboxylase activity nucleus|cytoplasm
YIL030C YIL030C SSM4 hom Verified 0.322773795441857 0.373433279938337 no 1848 0.386177269601654 1303 NA FT PROTEOLYSIS ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM UBIQUITIN LIGASE COMPLEX Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation ER-associated protein catabolic process ubiquitin-protein ligase activity nuclear envelope|integral to endoplasmic reticulum membrane|Doa10p ubiquitin ligase complex|integral to membrane|nuclear inner membrane
YPR159C-A_p YPR159C-A YPR159C-A hom Uncharacterized 0.322616494390752 0.373492850223568 no 1849 0.363100989249608 1202 NA Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YPR057W YPR057W BRR1 hom Verified 0.320840987460021 0.374165448282635 no 1850 0.309399928080997 1060 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING NUCLEUS snRNP protein component of spliceosomal snRNPs, required for pre-mRNA splicing and snRNP biogenesis; in null mutant newly-synthesized snRNAs are destabilized and 3'-end processing is slowed spliceosomal complex assembly RNA binding small nuclear ribonucleoprotein complex
YKL008C YKL008C LAC1 hom Verified 0.320503270778087 0.374293425656317 no 1851 0.37112120542456 1230 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p replicative cell aging|ceramide biosynthetic process sphingosine N-acyltransferase activity integral to membrane|endoplasmic reticulum
YGL041C_d YGL041C YGL041C hom Dubious 0.319551726757729 0.374654086700972 no 1852 0.381993008257636 1249 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YIL074C YIL074C SER33 hom Verified 0.319319526694967 0.374742113494895 no 1853 0.357274339749162 1213 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS 3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER33 has a paralog, SER3, that arose from the whole genome duplication serine family amino acid biosynthetic process phosphoglycerate dehydrogenase activity cytoplasm
YKR094C YKR094C RPL40B hom Verified 0.319058905113042 0.374840922630294 no 1854 0.363581143903895 1210 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RESPONSE TO DNA DAMAGE|TRANSLATION NUCLEUS|MITOCHONDRION RIBOSOME Ubiquitin-ribosomal 60S subunit protein L40B fusion protein; cleaved to yield ubiquitin and ribosomal protein L40B; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40B has a paralog, RPL40A, that arose from the whole genome duplication cytoplasmic translation|protein ubiquitination|ribosome biogenesis structural constituent of ribosome|protein tag mitochondrion|cytosolic large ribosomal subunit
YHR123W YHR123W EPT1 hom Verified 0.31879722453443 0.374940141528607 no 1855 0.328584622398021 1114 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability; EPT1 has a paralog, CPT1, that arose from the whole genome duplication phosphatidylethanolamine biosynthetic process|phosphatidylcholine biosynthetic process ethanolaminephosphotransferase activity|diacylglycerol cholinephosphotransferase activity integral to membrane|Golgi apparatus
YHR049W YHR049W FSH1 hom Verified 0.31878199589858 0.374945915878353 no 1856 0.350923797700654 1180 NA FT NUCLEUS Putative serine hydrolase that localizes to both the nucleus and cytoplasm; sequence is similar to S. cerevisiae Fsh2p and Fsh3p and the human candidate tumor suppressor OVCA2 biological_process hydrolase activity nucleus|cytoplasm
YCL034W YCL034W LSB5 hom Verified 0.318372502460276 0.375101196913964 no 1857 0.386754172477045 1253 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION CYTOSKELETON Protein of unknown function; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; may mediate disassembly of the Pan1 complex from the endocytic coat endocytosis|actin filament organization|actin cortical patch localization|actin cytoskeleton organization molecular_function cell cortex|cytoplasm|actin cortical patch
YBL098W YBL098W BNA4 hom Verified 0.318091527060704 0.375207755269643 no 1858 0.365031596302144 1206 NA FT OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM MITOCHONDRION Kynurenine 3-mono oxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; putative therapeutic target for Huntington disease de novo NAD biosynthetic process from tryptophan kynurenine 3-monooxygenase activity mitochondrial outer membrane|mitochondrion
YJL157C YJL157C FAR1 hom Verified 0.317576599951318 0.375403063224079 no 1859 0.338808807119296 1162 NA FT PROTEIN LOCALIZATION|CELL CYCLE|SIGNALING|CELL DIVISION NUCLEUS|SITE OF POLARIZED GROWTH Cyclin-dependent kinase inhibitor; mediates cell cycle arrest in response to pheromone; also forms a complex with Cdc24p, Ste4p, and Ste18p that may specify the direction of polarized growth during mating; potential Cdc28p substrate; relocalizes from nucleus to cytoplasm upon DNA replication stress maintenance of protein location in nucleus|pheromone-dependent signal transduction involved in conjugation with cellular fusion|cell cycle arrest in response to pheromone cyclin-dependent protein kinase inhibitor activity nucleus|mating projection tip|membrane|cytoplasm
YMR275C YMR275C BUL1 hom Verified 0.317025046585243 0.375612298668975 no 1860 0.385544373559314 1296 NA FT MITOCHONDRION ORGANIZATION PLASMA MEMBRANE UBIQUITIN LIGASE COMPLEX Ubiquitin-binding component of the Rsp5p E3-ubiquitin ligase complex; disruption causes temperature-sensitive growth, overexpression causes missorting of amino acid permeases; BUL1 has a paralog, BUL2, that arose from the whole genome duplication mitochondrion inheritance|protein monoubiquitination|protein polyubiquitination ubiquitin-ubiquitin ligase activity ubiquitin ligase complex|plasma membrane
YPL167C YPL167C REV3 hom Verified 0.316395265682627 0.375851254989447 no 1861 0.374590382796064 1236 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION|CHROMOSOME Catalytic subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair error-prone translesion synthesis|error-free translesion synthesis DNA-directed DNA polymerase activity nuclear chromatin|mitochondrion|zeta DNA polymerase complex
YBL078C YBL078C ATG8 hom Verified 0.316058351308532 0.375979109193079 no 1862 0.418041791636243 1388 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS ENDOMEMBRANE SYSTEM Component of autophagosomes and Cvt vesicles; unique ubiquitin-like protein whose conjugation target is the lipid phosphatidylethanolamine (PE); Atg8p-PE is anchored to membranes, is involved in phagophore expansion, and may mediate membrane fusion during autophagosome formation; deconjugation of Atg8p-PE is required for efficient autophagosome biogenesis piecemeal microautophagy of nucleus|mitochondrion degradation|cellular membrane fusion|ER to Golgi vesicle-mediated transport|CVT pathway|autophagic vacuole assembly molecular_function cytosol|fungal-type vacuole membrane|pre-autophagosomal structure|extrinsic to membrane|autophagic vacuole
YOL090W YOL090W MSH2 hom Verified 0.315712652308418 0.376110311189335 no 1863 0.382837550688154 1280 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|GENE SILENCING NUCLEUS|CHROMOSOME Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity and involved in interstrand cross-link repair; Msh2p-Msh6p binds to and hydrolyzes ATP mismatch repair|mitotic recombination|meiotic gene conversion|meiotic mismatch repair|removal of nonhomologous ends|DNA recombination|chromatin silencing at silent mating-type cassette loop DNA binding|single base insertion or deletion binding|ATP binding|Y-form DNA binding|double-strand/single-strand DNA junction binding|DNA insertion or deletion binding|guanine/thymine mispair binding|four-way junction DNA binding|ATPase activity MutSbeta complex|nuclear chromosome|MutSalpha complex|nucleus
YKL081W YKL081W TEF4 hom Verified 0.314419231196587 0.376601325926433 no 1864 0.384551121589167 1270 NA FT TRANSLATION MITOCHONDRION RIBOSOME Gamma subunit of translational elongation factor eEF1B, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex translational elongation translation elongation factor activity mitochondrion|ribosome|eukaryotic translation elongation factor 1 complex
YDR493W YDR493W MZM1 hom Verified 0.314211570352156 0.376680177760463 no 1865 0.361882796534883 1205 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Protein required for assembly of the cytochrome bc(1) complex; acts as a chaperone for Rip1p and facilitates its insertion into the complex at a late stage of assembly; localized to the mitochondrial matrix; null mutant exhibits a respiratory growth defect and reduced mitochondrial zinc levels, which is characteristic of mutations affecting bc(1) complex assembly; human LYRM7 is a functional ortholog mitochondrial respiratory chain complex III assembly molecular_function mitochondrion|mitochondrial matrix
YOR132W YOR132W VPS17 hom Verified 0.312610093825651 0.377288454235533 no 1866 0.37641862670694 1260 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM Subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde protein transport; peripheral membrane protein that assembles onto the membrane with Vps5p to promote vesicle formation; required for recruiting the retromer complex to the endosome membranes retrograde transport, endosome to Golgi protein transporter activity|phosphatidylinositol-3-phosphate binding endosome|retromer complex, outer shell|retromer complex
YBR228W YBR228W SLX1 hom Verified 0.312080283944708 0.377489754958619 no 1867 0.371521019109375 1269 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Subunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p DNA-dependent DNA replication 5'-flap endonuclease activity Slx1-Slx4 complex|nucleus
YNR058W YNR058W BIO3 hom Verified 0.310762115986861 0.377990735850471 no 1868 0.387420894355651 1284 NA FT KETONE METABOLISM|COFACTOR METABOLISM 7,8-diamino-pelargonic acid aminotransferase (DAPA), catalyzes the second step in the biotin biosynthesis pathway; BIO3 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis biotin biosynthetic process adenosylmethionine-8-amino-7-oxononanoate transaminase activity cytoplasm
YPL114W_d YPL114W YPL114W hom Dubious 0.310711536207276 0.378009963218123 no 1869 0.367992304432138 1234 NA Dubious open reading frame, unlikely to encode a functional protein; largely overlaps ORF YPL113C; diploid deletion in BY4743 strain background exhibits high budding index Unknown Unknown Unknown
YBR269C_p YBR269C FMP21 hom Uncharacterized 0.31036587744279 0.37814136982385 no 1870 0.378426528173699 1256 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YMR106C YMR106C YKU80 hom Verified 0.308881103992649 0.378705985630441 no 1871 0.371488408835943 1253 NA FT PROTEIN LOCALIZATION|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING NUCLEUS|CHROMOSOME Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair chromatin assembly or disassembly|protein localization to chromosome|chromatin silencing|double-strand break repair via nonhomologous end joining|donor selection|telomere maintenance|double-strand break repair via homologous recombination damaged DNA binding|RNA binding|DNA binding|telomeric DNA binding nuclear chromatin|nuclear telomeric heterochromatin|Ku70:Ku80 complex
YNR048W YNR048W YNR048W hom Verified 0.308530374016902 0.378839395814527 no 1872 0.379363211233709 1270 NA Protein that interacts with phospholipid translocase (flippase) Dnf3p; YNR048W has a paralog, CDC50, that arose from the whole genome duplication response to drug phospholipid-translocating ATPase activity integral to membrane
YLR068W YLR068W FYV7 hom Verified 0.308492219032244 0.378853910025918 no 1873 0.386858780483982 1291 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function nucleolus|nucleus
YLR334C_d YLR334C YLR334C hom Dubious 0.308182707703301 0.378971654895674 no 1874 0.35735714330419 1200 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps a stand-alone long terminal repeat sequence whose presence indicates a retrotransposition event occurred here Unknown Unknown Unknown
YGR053C_p YGR053C YGR053C hom Uncharacterized 0.307139173863816 0.379368720673149 no 1875 0.378644444267546 1256 NA Putative protein of unknown function biological_process molecular_function cellular_component
YLR082C YLR082C SRL2 hom Verified 0.305835739147906 0.379864857758645 no 1876 0.375986552051756 1232 NA FT NUCLEUS Protein of unknown function; overexpression suppresses the lethality caused by a rad53 null mutation nucleobase-containing compound metabolic process molecular_function nucleus|cytoplasm
YGL234W YGL234W ADE5,7 hom Verified 0.304576757704001 0.380344262050753 no 1877 0.379260800938671 1246 NA FT NUCLEOTIDE METABOLISM Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities purine nucleobase metabolic process|purine nucleotide biosynthetic process|'de novo' IMP biosynthetic process phosphoribosylamine-glycine ligase activity|phosphoribosylformylglycinamidine cyclo-ligase activity cytoplasm
YCL036W YCL036W GFD2 hom Verified 0.303998148589588 0.380564650831518 no 1878 0.382365076427324 1269 NA Protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; GFD2 has a paralog, YDR514C, that arose from the whole genome duplication biological_process molecular_function cellular_component
YDR532C YDR532C KRE28 hom Verified 0.303072001590749 0.380917495395585 no 1879 0.399620087837234 1298 NA FT ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME|CYTOSKELETON KINETOCHORE Subunit of a kinetochore-microtubule binding complex with Spc105p that bridges centromeric heterochromatin and kinetochore MAPs and motors, and is also required for sister chromatid bi-orientation and kinetochore binding of SAC components biological_process molecular_function chromosome, centromeric region|condensed nuclear chromosome kinetochore|spindle pole body
YLR219W YLR219W MSC3 hom Verified 0.301847908138331 0.381384003880275 no 1880 0.351114821357975 1168 NA FT CELL CYCLE PLASMA MEMBRANE Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; msc3 mutants are defective in directing meiotic recombination events to homologous chromatids; potential Cdc28p substrate; protein abundance increases in response to DNA replication stress reciprocal meiotic recombination molecular_function cellular_component
YOR113W YOR113W AZF1 hom Verified 0.301083263610763 0.381675501473986 no 1881 0.402283403689591 1343 NA FT TRANSCRIPTION FROM RNA POL II|CELL WALL ORG/BIOGENESIS NUCLEUS Zinc-finger transcription factor; in the presence of glucose, activates transcription of genes involved in growth and carbon metabolism; in nonfermentable carbon sources, activates transcription of genes involved in maintenance of cell wall integrity regulation of fungal-type cell wall organization|regulation of transcription from RNA polymerase II promoter|cellular response to carbohydrate stimulus RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YER121W_p YER121W YER121W hom Uncharacterized 0.30101204683458 0.381702654134438 no 1882 0.403648301151349 1280 NA Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy biological_process molecular_function cellular_component
YOL065C YOL065C INP54 hom Verified 0.299658547552375 0.382218810281716 no 1883 0.362151032558105 1184 NA FT PROTEIN LOCALIZATION|LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins phosphatidylinositol dephosphorylation phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity endoplasmic reticulum
YNR040W_p YNR040W YNR040W hom Uncharacterized 0.298587374643044 0.382627449906392 no 1884 0.386667668117369 1251 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YML007C-A_p YML007C-A YML007C-A hom Uncharacterized 0.298014860647944 0.382845910763907 no 1885 0.39241259014485 1332 NA FF|FT MITOCHONDRION Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria biological_process molecular_function mitochondrion
YBL028C YBL028C YBL028C hom Verified 0.297981368062142 0.382858692076157 no 1886 0.399924525770008 1332 NA FT NUCLEUS Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis biological_process molecular_function ribosome|nucleolus|nucleus|preribosome, large subunit precursor
YMR065W YMR065W KAR5 hom Verified 0.297502471822514 0.383041460569424 no 1887 0.382020749186143 1271 NA FT ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION Protein required for nuclear membrane fusion during karyogamy, localizes to the membrane with a soluble portion in the endoplasmic reticulum lumen, may form a complex with Jem1p and Kar2p; expression of the gene is regulated by pheromone karyogamy involved in conjugation with cellular fusion molecular_function mitochondrion|endoplasmic reticulum membrane
YDR079C-A YDR079C-A TFB5 hom Verified 0.295810734378867 0.383687312418015 no 1888 0.383244027588399 1288 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION NUCLEUS RNA POL II, HOLOENZYME Component of the RNA polymerase II general transcription and DNA repair factor TFIIH; involved in transcription initiation and in nucleotide-excision repair; homolog of Chlamydomonas reinhardtii REX1-S protein involved in DNA repair phosphorylation of RNA polymerase II C-terminal domain|nucleotide-excision repair|transcription from RNA polymerase II promoter core RNA polymerase binding transcription factor activity core TFIIH complex|holo TFIIH complex|nucleus
YER045C YER045C ACA1 hom Verified 0.294902165026375 0.384034309004088 no 1889 0.378969127926696 1262 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS ATF/CREB family basic leucine zipper (bZIP) transcription factor; binds as a homodimer to the ATF/CREB consensus sequence TGACGTCA; important for carbon source utilization; target genes include GRE2 and COS8; ACA1 has a paralog, CST6, that arose from the whole genome duplication positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YGR111W_p YGR111W YGR111W hom Uncharacterized 0.293462311603093 0.384584401474007 no 1890 0.410137009069615 1347 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus regulation of cell size molecular_function nucleus|cytoplasm
YOR034C-A_p YOR034C-A YOR034C-A hom Uncharacterized 0.29196999200653 0.385154783851615 no 1891 0.395854021417146 1313 NA Putative protein of unknown function; identified by expression profiling and mass spectrometry biological_process molecular_function cellular_component
YPR023C YPR023C EAF3 hom Verified 0.291413350831263 0.385367602473428 no 1892 0.367904458433442 1243 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME HISTONE ACETYLTRANSFERASE Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition DNA repair|histone acetylation|regulation of DNA-dependent DNA replication initiation|negative regulation of antisense RNA transcription|regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|histone deacetylation histone acetyltransferase activity Rpd3S complex|histone acetyltransferase complex|Rpd3L complex|NuA4 histone acetyltransferase complex
YDR358W YDR358W GGA1 hom Verified 0.291300681670649 0.385410683072277 no 1893 0.381167550717439 1234 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT GOLGI APPARATUS Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi Golgi to vacuole transport|protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|Golgi to endosome transport ubiquitin binding trans-Golgi network
YBR054W YBR054W YRO2 hom Verified 0.290676377035231 0.385649420122228 no 1894 0.387176453481955 1278 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Protein of unknown function with similarity to archaeal rhodopsins; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; transcriptionally regulated by Haa1p; YRO2 has a paralog, MRH1, that arose from the whole genome duplication biological_process molecular_function mitochondrion|integral to membrane|cellular bud
YGR104C YGR104C SRB5 hom Verified 0.290276742668856 0.385802264947039 no 1895 0.401371194563687 1315 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; required for proper termination of transcription for some genes; involved in telomere maintenance transcriptional open complex formation at RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter core RNA polymerase II binding transcription factor activity|RNA polymerase II transcription factor recruiting transcription factor activity|TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly core mediator complex
YEL039C YEL039C CYC7 hom Verified 0.289947883802723 0.385928054156588 no 1896 0.395714177256563 1287 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; protein abundance increases in response to DNA replication stress; CYC7 has a paralog, CYC1, that arose from the whole genome duplication mitochondrial electron transport, cytochrome c to oxygen|mitochondrial electron transport, ubiquinol to cytochrome c electron carrier activity mitochondrion|mitochondrial intermembrane space
YDR316W YDR316W OMS1 hom Verified 0.289798551220741 0.385985178144797 no 1897 0.401392900530448 1310 NA FT MITOCHONDRION Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif; multicopy suppressor of respiratory defects caused by OXA1 mutations biological_process S-adenosylmethionine-dependent methyltransferase activity mitochondrial envelope|mitochondrion
YIL156W YIL156W UBP7 hom Verified 0.289097008619409 0.386253571343861 no 1898 0.392846898250831 1290 NA FT PROTEOLYSIS Ubiquitin-specific protease that cleaves ubiquitin-protein fusions protein deubiquitination ubiquitin-specific protease activity cytoplasm
YDR266C YDR266C HEL2 hom Verified 0.289085927147128 0.386257811283691 no 1899 0.393349365391652 1288 NA RING finger ubiquitin ligase (E3); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; computational analysis suggests a role as a transcription factor biological_process molecular_function ribosome|cytoplasm
YMR137C YMR137C PSO2 hom Verified 0.288623184271093 0.386434875866019 no 1900 0.375263933591743 1235 NA FT RESPONSE TO DNA DAMAGE NUCLEUS Nuclease required for DNA single- and double-strand break repair; acts at a post-incision step in repair of breaks that result from interstrand cross-links produced by a variety of mono- and bi-functional psoralen derivatives; induced by UV-irradiation; forms nuclear foci upon DNA replication stress DNA repair|double-strand break repair damaged DNA binding|5'-3' exonuclease activity nucleus
YMR011W YMR011W HXT2 hom Verified 0.287871201100594 0.386722666188255 no 1901 0.385485545894268 1269 NA FT PLASMA MEMBRANE High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose glucose transport pentose transmembrane transporter activity|mannose transmembrane transporter activity|fructose transmembrane transporter activity|glucose transmembrane transporter activity integral to membrane|plasma membrane
YCR075W-A_p YCR075W-A YCR075W-A hom Uncharacterized 0.28767693427946 0.386797023877648 no 1902 0.392597432248103 1268 NA Putative protein of unknown function; identified by homology to Ashbya gossypii; YCR075W-A has a paralog, YNR034W-A, that arose from the whole genome duplication biological_process molecular_function cellular_component
YIL076W YIL076W SEC28 hom Verified 0.28716754496136 0.386992017777978 no 1903 0.374425980595586 1239 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth; protein abundance increases in response to DNA replication stress late endosome to vacuole transport via multivesicular body sorting pathway|ER to Golgi vesicle-mediated transport|vesicle coating molecular_function endosome|COPI vesicle coat
YAR014C YAR014C BUD14 hom Verified 0.286779555196214 0.387140559149062 no 1904 0.385034579342336 1307 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH Protein involved in bud-site selection; Bud14p-Glc7p complex is a cortical regulator of dynein; inhibitor of the actin assembly factor Bnr1p (formin); diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; relative distribution to the nucleus increases upon DNA replication stress regulation of cell shape during vegetative growth phase|regulation of protein localization|regulation of transcription, DNA-dependent|cytoskeleton organization|negative regulation of actin filament polymerization protein phosphatase type 1 regulator activity incipient cellular bud site|cellular bud neck|cellular bud tip
YMR241W YMR241W YHM2 hom Verified 0.284372297764048 0.388062543106502 no 1905 0.393571758873579 1315 NA FT ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS MITOCHONDRION Carrier protein that exports citrate from and imports oxoglutarate into the mitochondrion, causing net export of NADPH reducing equivalents; also associates with mt nucleoids and has a role in replication and segregation of the mt genome tricarboxylic acid transport|mitochondrial citrate transport|alpha-ketoglutarate transport|mitochondrial genome maintenance tricarboxylate secondary active transmembrane transporter activity|DNA binding mitochondrial nucleoid|mitochondrion|integral to membrane|mitochondrial inner membrane
YBR227C YBR227C MCX1 hom Verified 0.283506258033052 0.388394392578186 no 1906 0.393250614396061 1330 NA FT MITOCHONDRION Mitochondrial matrix protein; putative ATP-binding chaperone with non-proteolytic function; similar to bacterial ClpX proteins protein refolding molecular_function mitochondrion|mitochondrial matrix
YNL212W YNL212W VID27 hom Verified 0.282810338801186 0.388661114265376 no 1907 0.38719301418092 1250 NA Cytoplasmic protein of unknown function; possibly involved in vacuolar protein degradation; not essential for proteasome-dependent degradation of fructose-1,6-bisphosphatase (FBPase); null mutants exhibit normal growth biological_process molecular_function cytoplasm
YOR185C YOR185C GSP2 hom Verified 0.281378259271743 0.38921014568728 no 1908 0.407509255171841 1338 NA FT PROTEIN LOCALIZATION|SIGNALING|NUCLEOTIDE METABOLISM NUCLEUS GTP binding protein (mammalian Ranp homolog); involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas); Gsp1p homolog that is not required for viability; protein abundance increases in response to DNA replication stress nucleus organization GTPase activity integral to membrane|nucleus
YIL028W_d YIL028W YIL028W hom Dubious 0.280691449749587 0.389473533665481 no 1909 0.385195564867823 1265 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR233C YDR233C RTN1 hom Verified 0.280593116754884 0.389511248030045 no 1910 0.382106035613967 1265 NA FT PROTEIN COMPLEX ORG/BIOGENESIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS Reticulon protein; stabilizes membrane curvature; involved in nuclear pore assembly and maintenance of tubular ER morphology; mutant overexpressing RTN1 shows increase in tubular ER; interacts with exocyst subunit Sec6p, Yip3p, and Sbh1p; more abundant than Rtn2p; member of the RTNLA subfamily; mutants have reduced phosphatidylserine transfer between the ER and mitochondria; RTN1 has a paralog, RTN2, that arose from the whole genome duplication endoplasmic reticulum tubular network organization|endoplasmic reticulum organization|endoplasmic reticulum tubular network maintenance|nuclear pore complex assembly molecular_function integral to endoplasmic reticulum membrane|mitochondrion|Golgi apparatus|endoplasmic reticulum|cortical endoplasmic reticulum|endoplasmic reticulum tubular network
YKR070W_p YKR070W YKR070W hom Uncharacterized 0.278682821211286 0.390244123556572 no 1911 0.379416796653707 1220 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YLR390W YLR390W ECM19 hom Verified 0.27823996185573 0.390414080192849 no 1912 0.406468721385968 1371 NA FT CELL WALL ORG/BIOGENESIS MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies fungal-type cell wall organization molecular_function mitochondrion
YDR372C YDR372C VPS74 hom Verified 0.277920967843016 0.390536513864093 no 1913 0.423416883979918 1416 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33 retrograde vesicle-mediated transport, Golgi to ER|endoplasmic reticulum unfolded protein response|protein localization to Golgi apparatus enzyme binding|phosphatidylinositol-4-phosphate binding cytosol|Golgi apparatus|nucleus|extrinsic to membrane|cytoplasm
YAR042W YAR042W SWH1 hom Verified 0.2766110526141 0.391039388488779 no 1914 0.386902157859861 1275 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats; localizes to the Golgi and the nucleus-vacuole junction endocytosis|maintenance of cell polarity|exocytosis|sterol transport lipid binding|oxysterol binding|1-phosphatidylinositol binding|sterol transporter activity nuclear envelope|endoplasmic reticulum|Golgi trans cisterna|early endosome
YOL063C YOL063C CRT10 hom Verified 0.276545052372875 0.391064730718268 no 1915 0.382211638975502 1259 NA FT TRANSCRIPTION FROM RNA POL II Protein involved in transcriptional regulation of RNR2 and RNR3; expression of the gene is induced by DNA damage and null mutations confer increased resistance to hydroxyurea; N-terminal region has a leucine repeat and a WD40 repeat regulation of transcription from RNA polymerase II promoter molecular_function cellular_component
YML106W YML106W URA5 hom Verified 0.27561006522954 0.391423789029691 no 1916 0.39086065470725 1298 NA FT NUCLEOTIDE METABOLISM NUCLEUS Major orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA5 has a paralog, URA10, that arose from the whole genome duplication 'de novo' pyrimidine nucleobase biosynthetic process|pyrimidine ribonucleoside biosynthetic process orotate phosphoribosyltransferase activity nucleus|cytoplasm
YAL061W_p YAL061W BDH2 hom Uncharacterized 0.275459167037886 0.391481746367538 no 1917 0.357885028753118 1199 NA FT OXIDATION-REDUCTION PROCESS NUCLEUS Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3 biological_process oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor nucleus|cytoplasm
YDL095W YDL095W PMT1 hom Verified 0.274741697159757 0.391757346849566 no 1918 0.407780232567873 1357 NA FT PROTEIN LOCALIZATION|CARBOHYDRATE METABOLISM|PROTEOLYSIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein O-mannosyltransferase of the ER membrane; transfers mannose from dolichyl phosphate-D-mannose to protein serine and threonine residues; 1 of 7 related proteins involved in O-glycosylation which is essential for cell wall rigidity; involved in ER quality control; amino terminus faces cytoplasm, carboxyl terminus faces ER lumen ER-associated misfolded protein catabolic process|Unknown|protein exit from endoplasmic reticulum|protein O-linked mannosylation dolichyl-phosphate-mannose-protein mannosyltransferase activity integral to membrane|dolichyl-phosphate-mannose-protein mannosyltransferase complex
YHR139C-A_d YHR139C-A YHR139C-A hom Dubious 0.27414771840525 0.391985552011248 no 1919 0.389365699012306 1322 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YML053C_p YML053C YML053C hom Uncharacterized 0.273944203891787 0.39206375033347 no 1920 0.388579504284052 1274 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene biological_process molecular_function nucleus|cytoplasm
YDR535C_d YDR535C YDR535C hom Dubious 0.272903311564366 0.392463770427441 no 1921 0.425981444788003 1407 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YDR535C is not an essential gene. Unknown Unknown Unknown
YBR194W YBR194W AIM4 hom Verified 0.272215091167463 0.392728319382741 no 1922 0.422636762344803 1383 NA Protein proposed to be associated with the nuclear pore complex; null mutant is viable, displays elevated frequency of mitochondrial genome loss and is sensitive to freeze-thaw stress biological_process molecular_function cytoplasm
YDR094W_d YDR094W YDR094W hom Dubious 0.271987756718824 0.392815716661574 no 1923 0.377044689813066 1261 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2 Unknown Unknown Unknown
YOR284W YOR284W HUA2 hom Verified 0.270406385956836 0.393423813878405 no 1924 0.39395061205827 1285 NA Cytoplasmic protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly biological_process molecular_function cytoplasm
YDR424C YDR424C DYN2 hom Verified 0.268927136176015 0.393992877155008 no 1925 0.404193440358671 1339 NA FT PROTEIN COMPLEX ORG/BIOGENESIS ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON Cytoplasmic light chain dynein, microtubule motor protein; proposed to be involved in the assembly of the nuclear pore complex microtubule-based process|actin filament-based process|nuclear pore complex assembly molecular_function cytoplasmic dynein complex|cytoplasmic microtubule|peroxisome|nuclear pore
YOR243C YOR243C PUS7 hom Verified 0.268822372775519 0.394033187943134 no 1926 0.409467340280233 1361 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Pseudouridine synthase, catalyzes pseudouridylation at positions 35 and 56 in U2 snRNA, position 50 in 5S rRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); conserved in archaea, vertebrates, and some bacteria snRNA pseudouridine synthesis|tRNA pseudouridine synthesis|enzyme-directed rRNA pseudouridine synthesis pseudouridine synthase activity nucleus
YBR111W-A YBR111W-A SUS1 hom Verified 0.26846212638623 0.394171811958763 no 1927 0.459208597232715 1527 NA FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE|HISTONE ACETYLTRANSFERASE Component of both the SAGA histone acetylase and TREX-2 complexes; interacts with RNA polymerase II; involved in mRNA export coupled transcription activation and elongation; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP poly(A)+ mRNA export from nucleus|regulation of protein localization|nuclear retention of pre-mRNA at the site of transcription|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|histone deubiquitination|histone H3-K4 methylation|transcription elongation from RNA polymerase II promoter|histone H3-K79 methylation|positive regulation of transcription from RNA polymerase II promoter enzyme activator activity DUBm complex|nucleoplasm|transcription export complex 2|SAGA complex|nuclear pore
YIL096C_p YIL096C YIL096C hom Uncharacterized 0.267406035436383 0.394578276491609 no 1928 0.386874713352008 1278 NA FT NUCLEUS Putative S-adenosylmethionine-dependent methyltransferase; associates with precursors of the 60S ribosomal subunit; predicted to be involved in ribosome biogenesis biological_process S-adenosylmethionine-dependent methyltransferase activity nucleolus|nucleus
YDL085C-A_p YDL085C-A YDL085C-A hom Uncharacterized 0.266099969862232 0.395081109104447 no 1929 0.401864505371685 1345 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus biological_process molecular_function nucleus|cytoplasm
YJL197W YJL197W UBP12 hom Verified 0.262915258300714 0.396307947755318 no 1930 0.391989943859242 1310 NA FT PROTEOLYSIS NUCLEUS Ubiquitin-specific protease; cleaves ubiquitin from ubiquitinated proteins; present in the nucleus and cytoplasm biological_process ubiquitin-specific protease activity nucleus|cytoplasm
YGR042W YGR042W YGR042W hom Verified 0.262015600989914 0.396654707204508 no 1931 0.387427908385931 1276 NA FT NUCLEUS Protein of unknown function; involved in maintenance of proper telomere length; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; forms nuclear foci upon DNA replication stress biological_process molecular_function nucleus|cytoplasm
YDR179C YDR179C CSN9 hom Verified 0.260220453656838 0.3973468639265 no 1932 0.397783453015649 1315 NA FT SIGNALING NUCLEUS Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|cullin deneddylation molecular_function signalosome
YGL202W YGL202W ARO8 hom Verified 0.259107915115609 0.39777598896076 no 1933 0.392718959619261 1299 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis aromatic amino acid family metabolic process aromatic-amino-acid:2-oxoglutarate aminotransferase activity|2-aminoadipate transaminase activity cytoplasm
YOR177C YOR177C MPC54 hom Verified 0.258761885015012 0.397909483902579 no 1934 0.406477883063638 1342 NA FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION NUCLEUS|CYTOSKELETON Component of the meiotic outer plaque, a membrane-organizing center which is assembled on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; potential Cdc28p substrate ascospore wall assembly|vesicle docking structural molecule activity spindle pole body
YLR385C YLR385C SWC7 hom Verified 0.258313625213902 0.398082435807757 no 1935 0.389757162531106 1296 NA FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin chromatin remodeling molecular_function Swr1 complex|nucleus
YLR174W YLR174W IDP2 hom Verified 0.257849353818247 0.398261586573215 no 1936 0.383695320065441 1289 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM Cytosolic NADP-specific isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose; IDP2 has a paralog, IDP3, that arose from the whole genome duplication glutamate biosynthetic process|isocitrate metabolic process isocitrate dehydrogenase (NADP+) activity cytosol
YJR134C YJR134C SGM1 hom Verified 0.257472280998987 0.39840710536569 no 1937 0.397827158096164 1333 NA FT GOLGI APPARATUS Protein of unknown function, required for wild-type growth rate on galactose and mannose; localizes to COPI coated vesicles and the Golgi apparatus biological_process molecular_function COPI-coated vesicle|Golgi apparatus
YMR127C YMR127C SAS2 hom Verified 0.256701122284881 0.398704752557443 no 1938 0.390504702531024 1277 NA FT CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME HISTONE ACETYLTRANSFERASE Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family histone acetylation|histone exchange|chromatin silencing at telomere acetyltransferase activity|histone acetyltransferase activity nuclear chromatin|SAS acetyltransferase complex|nuclear chromosome, telomeric region
YGL025C YGL025C PGD1 hom Verified 0.2559426376123 0.398997565382448 no 1939 0.430093356371331 1440 NA FF|FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II repressing transcription factor binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription factor recruiting transcription factor activity core mediator complex
YNR007C YNR007C ATG3 hom Verified 0.255908143516505 0.399010883172469 no 1940 0.410744802229176 1366 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS E2-like enzyme involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; plays a role in formation of Atg8p-phosphatidylethanolamine conjugates, which are involved in membrane dynamics during autophagy and Cvt; interaction with Atg8p is regulated by its acetylation by Esa1p (catalytic subunit of NuA4 histone acetyltransferase complex) while attenuation of Atg3 acetylation is mediated by histone deacetylase Rpd3p C-terminal protein lipidation|piecemeal microautophagy of nucleus|mitochondrion degradation|CVT pathway|autophagic vacuole assembly Atg8 ligase activity cytosol|cytoplasm
YLR062C_d YLR062C BUD28 hom Dubious 0.255671527674806 0.399102241108087 no 1941 0.413682930786125 1372 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene RPL22A; diploid mutant displays a weak budding pattern phenotype in a systematic assay Unknown Unknown Unknown
YER176W YER176W ECM32 hom Verified 0.254054009206279 0.399726916594871 no 1942 0.381240466241271 1289 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes regulation of translational termination RNA helicase activity|DNA helicase activity polysome
YDL210W YDL210W UGA4 hom Verified 0.253654466212477 0.399881257195407 no 1943 0.386558480355684 1248 NA Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane gamma-aminobutyric acid transport|putrescine transport|transmembrane transport putrescine transmembrane transporter activity|gamma-aminobutyric acid:hydrogen symporter activity fungal-type vacuole membrane|integral to membrane
YGR088W YGR088W CTT1 hom Verified 0.252769663731005 0.40022310570915 no 1944 0.366625004010249 1214 NA FT OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide response to reactive oxygen species catalase activity cytoplasm
YAR047C_d YAR047C YAR047C hom Dubious 0.252722600183365 0.400241291124693 no 1945 0.396244214144027 1301 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR365W_d YLR365W YLR365W hom Dubious 0.252251832842771 0.400423208129197 no 1946 0.380621482258435 1247 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious gene YLR364C-A; YLR365W is not an essential gene Unknown Unknown Unknown
YNL044W YNL044W YIP3 hom Verified 0.252186617346776 0.400448410833621 no 1947 0.40160931558687 1319 NA FT VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Protein localized to COPII vesicles, proposed to be involved in ER to Golgi transport; interacts with members of the Rab GTPase family and Yip1p; also interacts with Rtn1p ER to Golgi vesicle-mediated transport molecular_function Golgi apparatus|endoplasmic reticulum|ER to Golgi transport vesicle
YEL056W YEL056W HAT2 hom Verified 0.251828349555491 0.400586871779002 no 1948 0.387543639572987 1261 NA FT CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING NUCLEUS HISTONE ACETYLTRANSFERASE Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing histone acetylation|chromatin assembly or disassembly|chromatin silencing at telomere histone acetyltransferase activity|histone binding histone acetyltransferase complex|nucleus|cytoplasm
YOL030W YOL030W GAS5 hom Verified 0.251825185151964 0.400588094792245 no 1949 0.401837018772841 1313 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM 1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall (1->3)-beta-D-glucan metabolic process 1,3-beta-glucanosyltransferase activity fungal-type cell wall|integral to membrane
YOL119C YOL119C MCH4 hom Verified 0.250736516981268 0.401008912925937 no 1950 0.380087849728794 1239 NA Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport transport monocarboxylic acid transmembrane transporter activity|transporter activity fungal-type vacuole membrane|integral to membrane
YBR156C YBR156C SLI15 hom Verified 0.250497557862056 0.401101296528626 no 1951 0.403572540590475 1320 NA FT CELL DIVISION|PROTEIN PHOSPHORYLATION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME|CYTOSKELETON Subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly chromosome segregation|protein phosphorylation|regulation of cytokinesis protein kinase activator activity spindle microtubule|spindle midzone|chromosome passenger complex|kinetochore microtubule
YOR085W YOR085W OST3 hom Verified 0.249589622289752 0.40145236242914 no 1952 0.398655811681067 1313 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins protein glycosylation|protein complex assembly|protein O-linked mannosylation|protein N-linked glycosylation dolichyl-diphosphooligosaccharide-protein glycotransferase activity oligosaccharyltransferase complex|integral to membrane
YLR438W YLR438W CAR2 hom Verified 0.249143869606961 0.401624748032468 no 1953 0.405077518195396 1341 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS L-ornithine transaminase (OTAse); catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive; protein abundance increases in response to DNA replication stress ornithine metabolic process|arginine catabolic process ornithine-oxo-acid transaminase activity cytosol|nucleus|cytoplasm
YHL028W YHL028W WSC4 hom Verified 0.249123220093113 0.401632734267845 no 1954 0.393939678180433 1299 NA FT PROTEIN LOCALIZATION|CELL WALL ORG/BIOGENESIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM ER membrane protein involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3 response to heat|SRP-dependent cotranslational protein targeting to membrane, translocation|protein targeting to ER|response to stress transmembrane signaling receptor activity endoplasmic reticulum membrane
YJL063C YJL063C MRPL8 hom Verified 0.248485653708264 0.401879334376589 no 1955 0.411188165828022 1397 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial genome maintenance|mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YLR024C YLR024C UBR2 hom Verified 0.247576496781832 0.402231048762632 no 1956 0.389861535767001 1288 NA Cytoplasmic ubiquitin-protein ligase (E3); required for ubiquitylation of Rpn4p; mediates formation of a Mub1p-Ubr2p-Rad6p complex protein monoubiquitination ubiquitin-protein ligase activity cytoplasm
YNL024C_p YNL024C YNL024C hom Uncharacterized 0.245766488230267 0.40293150001589 no 1957 0.404768119308541 1367 NA Putative methyltransferase; has seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; despite similarity to methyltransferases, null mutant does not display alterations in lysine methylation pattern biological_process S-adenosylmethionine-dependent methyltransferase activity cytoplasm
YGL179C YGL179C TOS3 hom Verified 0.244313676846396 0.403493945890615 no 1958 0.393236040637351 1333 NA FT CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome protein phosphorylation|glucose metabolic process protein serine/threonine kinase activity|protein kinase activity nucleus|cytoplasm
YML110C YML110C COQ5 hom Verified 0.243935553103572 0.40364036667355 no 1959 0.40514790397569 1318 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes ubiquinone biosynthetic process|aerobic respiration 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity mitochondrion|mitochondrial matrix
YOR226C YOR226C ISU2 hom Verified 0.24336136296793 0.403862736027647 no 1960 0.399135698073491 1310 NA FT RNA PROCESSING|ION HOMEOSTASIS|ION HOMEOSTASIS|COFACTOR METABOLISM MITOCHONDRION Protein required for synthesis of iron-sulfur proteins; localized to the mitochondrial matrix; performs a scaffolding function in mitochondria during Fe/S cluster assembly; involved in Fe-S cluster assembly for both mitochondrial and cytosolic proteins; isu1 isu2 double mutant is inviable; protein abundance increases in response to DNA replication stress; evolutionarily conserved cellular iron ion homeostasis|iron-sulfur cluster assembly|tRNA wobble uridine modification molecular_function mitochondrial matrix
YGR204C-A_p YGR204C-A YGR204C-A hom Uncharacterized 0.243162231224281 0.403939861989102 no 1961 0.399729987777883 1333 NA Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YGR149W_p YGR149W YGR149W hom Uncharacterized 0.242674124494628 0.404128926999662 no 1962 0.394447529639807 1294 NA Putative protein of unknown function; predicted to be an integal membrane protein biological_process molecular_function integral to membrane
YJR146W_p YJR146W YJR146W hom Uncharacterized 0.242388500479245 0.404239572019721 no 1963 0.402545772218537 1340 NA Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps HMS2 biological_process molecular_function cellular_component
YGR133W YGR133W PEX4 hom Verified 0.241643898767321 0.404528051796353 no 1964 0.397970887812602 1301 NA FT PROTEIN LOCALIZATION|SIGNALING|PEROXISOME ORGANIZATION Peroxisomal ubiquitin conjugating enzyme required for peroxisomal matrix protein import and peroxisome biogenesis peroxisome organization|protein import into peroxisome matrix, receptor recycling|protein autoubiquitination|protein monoubiquitination|protein polyubiquitination ubiquitin-protein ligase activity peroxisome
YER037W YER037W PHM8 hom Verified 0.239493222517948 0.405361575612377 no 1965 0.394434754068956 1286 NA FT RESPONSE TO NUTRIENT LEVELS NUCLEUS Lysophosphatidic acid (LPA) phosphatase involved in LPA hydrolysis in response to phosphate starvation; phosphatase activity is soluble and Mg2+ dependent; expression is induced by low phosphate levels and by inactivation of Pho85p cellular response to phosphate starvation lysophosphatidic acid phosphatase activity nucleus|cytoplasm
YJR130C YJR130C STR2 hom Verified 0.239010900282449 0.405548565233308 no 1966 0.402524488337107 1335 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Cystathionine gamma-synthase, converts cysteine into cystathionine sulfur compound metabolic process|transsulfuration cystathionine gamma-synthase activity nucleus|cytoplasm
YDR165W YDR165W TRM82 hom Verified 0.238933931505734 0.405578406952913 no 1967 0.432627428816636 1442 NA FT RNA PROCESSING NUCLEUS Catalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p tRNA methylation tRNA (guanine-N7-)-methyltransferase activity tRNA methyltransferase complex|nucleus
YLR263W YLR263W RED1 hom Verified 0.238588841332271 0.405712209303778 no 1968 0.385755079749858 1267 NA FT CELL CYCLE|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Protein component of the synaptonemal complex axial elements, involved in chromosome segregation during the first meiotic division; critical for coupling checkpoint signaling to SC formation; interacts with Hop1p, Mec3p and Ddc1p synaptonemal complex assembly|meiotic recombination checkpoint|positive regulation of catalytic activity chromatin DNA binding|structural molecule activity lateral element
YDR265W YDR265W PEX10 hom Verified 0.237156908461939 0.406267532401298 no 1969 0.405193640706781 1331 NA FT PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION Peroxisomal membrane E3 ubiquitin ligase, required for for Ubc4p-dependent Pex5p ubiquitination and peroxisomal matrix protein import; contains zinc-binding RING domain; mutations in human homolog cause various peroxisomal disorders protein import into peroxisome matrix|protein ubiquitination ubiquitin-protein ligase activity|protein binding peroxisomal membrane
YKL113C YKL113C RAD27 hom Verified 0.236878625862685 0.406375476112017 no 1970 0.41871173194523 1392 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION 5' to 3' exonuclease, 5' flap endonuclease, required for Okazaki fragment processing and maturation as well as for long-patch base-excision repair; member of the S. pombe RAD2/FEN1 family double-strand break repair via nonhomologous end joining|replicative cell aging|DNA replication, removal of RNA primer|base-excision repair, base-free sugar-phosphate removal|gene conversion at mating-type locus, DNA repair synthesis 5'-3' exonuclease activity|5'-flap endonuclease activity mitochondrion|nucleus
YPL223C YPL223C GRE1 hom Verified 0.23680798695882 0.40640287754004 no 1971 0.421243193111646 1373 NA Hydrophilin essential in dessication-rehydration process; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway biological_process molecular_function cytoplasm
YLR342W YLR342W FKS1 hom Verified 0.236089732342469 0.406681520581103 no 1972 0.407670741761015 1356 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM MITOCHONDRION|PLASMA MEMBRANE|CYTOSKELETON Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling (1->3)-beta-D-glucan biosynthetic process|positive regulation of endocytosis|regulation of cell size 1,3-beta-D-glucan synthase activity mitochondrion|1,3-beta-D-glucan synthase complex|integral to membrane|plasma membrane|cellular bud neck|cellular bud tip|actin cortical patch
YDR131C_p YDR131C YDR131C hom Uncharacterized 0.235079107765934 0.40707366697678 no 1973 0.394576124343713 1314 NA FT PROTEOLYSIS F-box protein, substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity|protein binding, bridging SCF ubiquitin ligase complex
YJR122W YJR122W IBA57 hom Verified 0.235018146204372 0.407097324497503 no 1974 0.426703390358566 1406 NA FF|FT COFACTOR METABOLISM MITOCHONDRION Mitochondrial matrix protein involved in the incorporation of iron-sulfur clusters into mitochondrial aconitase-type proteins; activates the radical-SAM family members Bio2p and Lip5p; interacts with Ccr4p in the two-hybrid system iron-sulfur cluster assembly molecular_function mitochondrion|mitochondrial matrix
YIR036C_p YIR036C IRC24 hom Uncharacterized 0.234816193190487 0.40717569937945 no 1975 0.408594878539591 1351 NA FT OXIDATION-REDUCTION PROCESS Putative benzil reductase;(GFP)-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS; sequence similarity with short-chain dehydrogenase/reductases; null mutant has increased spontaneous Rad52p foci biological_process molecular_function integral to membrane|cytoplasm
YKR010C YKR010C TOF2 hom Verified 0.233819599712377 0.407562516463813 no 1976 0.399525154402081 1346 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CHROMOSOME SEGREGATION|GENE SILENCING NUCLEUS|MITOCHONDRION Protein required for rDNA silencing and mitotic rDNA condensation; stimulates Cdc14p phosphatase activity and biphasic release to promote rDNA repeat segregation; required for condensin recruitment to the replication fork barrier site; TOF2 has a paralog, NET1, that arose from the whole genome duplication nucleolus organization|rDNA condensation|chromatin silencing at rDNA|protein localization to nucleolar rDNA repeats phosphatase activator activity mitochondrion|nucleolus
YOR033C YOR033C EXO1 hom Verified 0.233278273392223 0.407772664281944 no 1977 0.411625512190977 1378 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS 5'-3' exonuclease and flap-endonuclease; involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved N and I nuclease domains; relative distribution to the nucleus increases upon DNA replication stress mismatch repair|telomeric 3' overhang formation|DNA double-strand break processing|meiotic DNA double-strand break processing|telomere maintenance|gene conversion at mating-type locus, DNA double-strand break processing 5'-3' exonuclease activity|5'-flap endonuclease activity nucleus
YDR169C-A_p YDR169C-A YDR169C-A hom Uncharacterized 0.232970974756784 0.407891972229669 no 1978 0.425122017321412 1402 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YJL132W_p YJL132W YJL132W hom Uncharacterized 0.232938326756427 0.407904648238533 no 1979 0.414591124110147 1383 NA Putative protein of unknown function; localizes to the membrane fraction; possible Zap1p-regulated target gene induced by zinc deficiency; YJL132W is a non-essential gene biological_process molecular_function membrane
YDR448W YDR448W ADA2 hom Verified 0.232642125687237 0.408019656542038 no 1980 0.453032411799025 1488 NA FF|FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS HISTONE ACETYLTRANSFERASE Transcription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes chromatin silencing at rDNA|chromatin modification|regulation of transcription from RNA polymerase II promoter|positive regulation of histone acetylation|chromatin silencing at telomere chromatin binding|transcription coactivator activity|histone acetyltransferase activity|phosphatidylserine binding SLIK (SAGA-like) complex|Ada2/Gcn5/Ada3 transcription activator complex|SAGA complex
YDR515W YDR515W SLF1 hom Verified 0.231755702015941 0.408363882497371 no 1981 0.415417871597572 1364 NA FT TRANSLATION|ION HOMEOSTASIS|ION HOMEOSTASIS RNA binding protein that associates with polysomes; may be involved in regulating mRNA translation; involved in the copper-dependent mineralization of copper sulfide complexes on cell surface in cells cultured in copper salts; SLF1 has a paralog, SRO9, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress cellular copper ion homeostasis|regulation of translation RNA binding polysome|cytoplasm
YLR250W YLR250W SSP120 hom Verified 0.231714808510663 0.408379764429321 no 1982 0.413399654675173 1354 NA Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern biological_process molecular_function cytoplasm
YBR261C YBR261C TAE1 hom Verified 0.231676570514188 0.408394615169591 no 1983 0.39454791713874 1311 NA FT TRANSLATION AdoMet-dependent proline methyltransferase; catalyzes the dimethylation of ribosomal proteins Rpl12 and Rps25 at N-terminal proline residues; has a role in protein synthesis; fusion protein localizes to the cytoplasm cytoplasmic translation|N-terminal peptidyl-proline dimethylation N-terminal protein N-methyltransferase activity cytosol|cytoplasm
YLR408C_p YLR408C BLS1 hom Uncharacterized 0.231570556710161 0.408435789130552 no 1984 0.392843140424582 1293 NA Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene biological_process molecular_function endosome|BLOC-1 complex
YJR039W_p YJR039W YJR039W hom Uncharacterized 0.230468041239241 0.408864047251619 no 1985 0.379927948031835 1263 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YNR061C YNR061C YNR061C hom Verified 0.230102145501021 0.409006198877237 no 1986 0.397546462231353 1326 NA Protein of unknown function; relocalizes from vacuole to cytoplasm upon DNA replication stress biological_process molecular_function integral to membrane|fungal-type vacuole
YMR165C YMR165C PAH1 hom Verified 0.229950196704477 0.409065234972765 no 1987 0.402296335909534 1331 NA FT LIPID METABOLISM|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Mg2+-dependent phosphatidate (PA) phosphatase; dephosphorylates PA to yield diacylglycerol; responsible for de novo lipid synthesis and formation of lipid droplets; phosphorylation by Pho80p-Pho85p decreases catalytic activity and alters Pah1p localization and abundance; phosphorylation by protein kinase A decreases catalytic efficiency; dephosphorylation by Nem1p-Spo7p anchors Pah1p to the membrane increasing substrate catalysis; homologous to mammalian lipins 1 and 2 plasmid maintenance|vacuole fusion, non-autophagic|lipid particle organization|aerobic respiration|phospholipid biosynthetic process phosphatidate phosphatase activity cytosol|nuclear membrane|vacuole|cytoplasm|extrinsic to membrane
YGR012W YGR012W YGR012W hom Verified 0.228974596649584 0.409444330284679 no 1988 0.40324631467611 1325 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Putative cysteine synthase, localized to the mitochondrial outer membrane cysteine biosynthetic process cysteine synthase activity mitochondrial outer membrane|mitochondrion
YPR051W YPR051W MAK3 hom Verified 0.227410056925165 0.410052450420968 no 1989 0.430838627728984 1430 NA FT NUCLEUS Catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus N-terminal protein amino acid acetylation peptide alpha-N-acetyltransferase activity NatC complex
YPL240C YPL240C HSP82 hom Verified 0.227101205057816 0.410172523514531 no 1990 0.422967984411682 1408 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION Hsp90 chaperone; redundant in function with Hsc82p; required for pheromone signaling, negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding, nucleotide addition; protein abundance increases in response to DNA replication stress; contains two acid-rich unstructured regions that promote solubility of chaperone-substrate complexes; HSP82 has a paralog, HSC82, that arose from the whole genome duplication proteasome assembly|positive regulation of telomere maintenance via telomerase|box C/D snoRNP assembly|response to stress|protein refolding|protein targeting to mitochondrion|response to osmotic stress|'de novo' protein folding unfolded protein binding|ATPase activity, coupled cytoplasm
YGR132C YGR132C PHB1 hom Verified 0.225890078876748 0.410643457160377 no 1991 0.396793195560377 1296 NA FT MEMBRANE ORGANIZATION|PROTEOLYSIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation mitochondrion inheritance|protein folding|negative regulation of proteolysis|replicative cell aging|mitochondrion morphogenesis|inner mitochondrial membrane organization molecular_function mitochondrion|mitochondrial inner membrane
YKR065C YKR065C PAM17 hom Verified 0.225888654794505 0.410644010975717 no 1992 0.405571035337782 1349 NA FT PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Constituent of the TIM23 complex; proposed alternatively to be a component of the import motor (PAM complex) or to interact with and modulate the core TIM23 (Translocase of the Inner mitochondrial Membrane) complex; protein abundance increases in response to DNA replication stress protein import into mitochondrial matrix molecular_function mitochondrion|presequence translocase-associated import motor
YHR187W YHR187W IKI1 hom Verified 0.224611527449938 0.411140748205334 no 1993 0.40240408198965 1349 NA FT RNA PROCESSING NUCLEUS Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin tRNA modification tRNA binding|ATPase activity Elongator holoenzyme complex|nucleus|cytoplasm
YPL127C YPL127C HHO1 hom Verified 0.222932630272614 0.411793970046924 no 1994 0.409667242257859 1377 NA FT CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Histone H1, linker histone with roles in meiosis and sporulation; decreasing levels early in sporulation may promote meiosis, and increasing levels during sporulation facilitate compaction of spore chromatin; binds to promoters and within genes in mature spores; may be recruited by Ume6p to promoter regions, contributing to transcriptional repression outside of meiosis; suppresses DNA repair involving homologous recombination negative regulation of DNA recombination|negative regulation of chromatin silencing|regulation of transcription, DNA-dependent DNA binding nucleus|nuclear nucleosome
YDL045W-A YDL045W-A MRP10 hom Verified 0.222801761271453 0.411844898583395 no 1995 0.426865755840942 1430 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit; contains twin cysteine-x9-cysteine motifs mitochondrial translation|mitochondrial respiratory chain complex assembly structural constituent of ribosome mitochondrial small ribosomal subunit
YGR234W YGR234W YHB1 hom Verified 0.2222305125526 0.412067221173958 no 1996 0.404472862107786 1318 NA FT OXIDATION-REDUCTION PROCESS MITOCHONDRION Nitric oxide oxidoreductase; flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress response to stress nitric oxide reductase activity cytosol|mitochondrion|mitochondrial matrix|cytoplasm
YMR159C YMR159C ATG16 hom Verified 0.221267189857942 0.412442197765811 no 1997 0.412777428616561 1368 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Conserved protein involved in autophagy; interacts with Atg12p-Atg5p conjugates to form Atg12p-Atg5p-Atg16p multimers, which localize to the pre-autophagosomal structure and are required for autophagy; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress C-terminal protein lipidation|piecemeal microautophagy of nucleus|mitochondrion degradation|macroautophagy|CVT pathway protein binding, bridging|Atg8 ligase activity Atg12-Atg5-Atg16 complex|pre-autophagosomal structure
YNL233W YNL233W BNI4 hom Verified 0.220078106871564 0.412905162503756 no 1998 0.447089474428801 1471 NA FT PROTEIN LOCALIZATION|CELL DIVISION|CARBOHYDRATE METABOLISM SITE OF POLARIZED GROWTH|CYTOSKELETON Targeting subunit for Glc7p protein phosphatase, localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p asymmetric protein localization|barrier septum assembly|chitin biosynthetic process protein binding incipient cellular bud site|cellular bud neck septin collar|cellular bud neck|septin ring
YHR045W_p YHR045W YHR045W hom Uncharacterized 0.219747204408455 0.413034019641711 no 1999 0.411153855433789 1345 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS ENDOPLASMIC RETICULUM Putative protein of unknown function; possible role in iron metabolism and/or amino acid and carbohydrate metabolism; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum biological_process molecular_function endoplasmic reticulum
YBR300C_d YBR300C YBR300C hom Dubious 0.219621664105159 0.413082908899228 no 2000 0.401303258826838 1327 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR301W; YBR300C is not an essential gene Unknown Unknown Unknown
YGR200C YGR200C ELP2 hom Verified 0.21844317144238 0.413541915829301 no 2001 0.420329018464166 1393 NA FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin regulation of transcription from RNA polymerase II promoter|protein urmylation|tRNA wobble uridine modification molecular_function Elongator holoenzyme complex|nucleus|cytoplasm
YML022W YML022W APT1 hom Verified 0.218169690697472 0.413648449791878 no 2002 0.376774411225588 1251 NA FT NUCLEOTIDE METABOLISM NUCLEUS Adenine phosphoribosyltransferase; catalyzes the formation of AMP from adenine and 5-phosphoribosylpyrophosphate; involved in the salvage pathway of purine nucleotide biosynthesis; APT1 has a paralog, APT2, that arose from the whole genome duplication AMP biosynthetic process|adenine salvage adenine phosphoribosyltransferase activity nucleus|cytoplasm
YER011W YER011W TIR1 hom Verified 0.217528031969447 0.413898431806392 no 2003 0.38851203370149 1292 NA Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking response to stress structural constituent of cell wall fungal-type cell wall
YDL051W YDL051W LHP1 hom Verified 0.217232028656265 0.414013762669956 no 2004 0.415384891857145 1355 NA FT RNA PROCESSING NUCLEUS RNA binding protein required for maturation of tRNA and U6 snRNA precursors; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen tRNA processing RNA binding|tRNA binding nucleoplasm|nucleolus|nucleus
YNL295W_p YNL295W YNL295W hom Uncharacterized 0.216449459278271 0.414318708473894 no 2005 0.391699024611832 1283 NA Putative protein of unknown function biological_process molecular_function cellular_component
YIL098C YIL098C FMC1 hom Verified 0.216402659765936 0.414336946597918 no 2006 0.425375010267249 1420 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial matrix protein, required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase; null mutant temperature sensitive growth on glycerol is suppressed by multicopy expression of Odc1p mitochondrial proton-transporting ATP synthase complex assembly molecular_function mitochondrion|mitochondrial matrix
YBR059C YBR059C AKL1 hom Verified 0.215031130871467 0.414871523651688 no 2007 0.416955647946627 1371 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION SITE OF POLARIZED GROWTH Ser-Thr protein kinase, member (with Ark1p and Prk1p) of the Ark kinase family; involved in endocytosis and actin cytoskeleton organization regulation of endocytosis|protein phosphorylation|actin cytoskeleton organization protein kinase activity cellular bud neck|cytoplasm
YNL335W_p YNL335W DDI3 hom Uncharacterized 0.21474400100267 0.414983457465493 no 2008 0.415221522524946 1386 NA Protein of unknown function; expression is induced over 100-fold by DNA damage; induction decreased in rad6 and rad18 mutants biological_process molecular_function cellular_component
YDL104C YDL104C QRI7 hom Verified 0.213626024264756 0.415419351709327 no 2009 0.429869522248614 1401 NA FT RNA PROCESSING|PROTEOLYSIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Highly conserved mitochondrial protein, essential for t6A modification of mitochondrial tRNAs that decode ANN codons; similar to Kae1p and E. coli YgjD, both of which are also required for tRNA t6A modification mitochondrial tRNA threonylcarbamoyladenosine modification molecular_function mitochondrion
YPR127W YPR127W YPR127W hom Verified 0.213491296340931 0.415471888577872 no 2010 0.406831438349909 1355 NA FT OXIDATION-REDUCTION PROCESS NUCLEUS Putative pyridoxine 4-dehydrogenase; differentially expressed during alcoholic fermentation; expression activated by transcription factor YRM1/YOR172W; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus biological_process molecular_function nucleus|cytoplasm
YGR039W_d YGR039W YGR039W hom Dubious 0.212760872245745 0.415756742187944 no 2011 0.435013019636374 1459 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the Autonomously Replicating Sequence ARS722 Unknown Unknown Unknown
YMR114C YMR114C YMR114C hom Verified 0.211832283842229 0.416118940578289 no 2012 0.413144052938354 1345 NA FT NUCLEUS Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR114C is not an essential gene biological_process molecular_function ribosome|nucleus|cytoplasm
YJL108C YJL108C PRM10 hom Verified 0.21144642636676 0.416269466291169 no 2013 0.428136814904787 1405 NA Pheromone-regulated protein, proposed to be involved in mating; predicted to have 5 transmembrane segments; induced by treatment with 8-methoxypsoralen and UVA irradiation biological_process molecular_function integral to membrane
YLR262C YLR262C YPT6 hom Verified 0.211202612335577 0.4163645861916 no 2014 0.455791299496975 1505 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING GOLGI APPARATUS|PLASMA MEMBRANE Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6 intracellular protein transport|retrograde transport, endosome to Golgi GTPase activity Golgi apparatus
YGL078C YGL078C DBP3 hom Verified 0.210042152482277 0.416817386926541 no 2015 0.417851422210776 1398 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS RNA-Dependent ATPase, member of DExD/H-box family; involved in cleavage of site A3 within the ITS1 spacer during rRNA processing; not essential for growth, but deletion causes severe slow-growth phenotype endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) RNA-dependent ATPase activity nucleolus|preribosome, large subunit precursor
YER044C YER044C ERG28 hom Verified 0.20975341387702 0.416930067239737 no 2016 0.423005869744465 1388 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Endoplasmic reticulum membrane protein, may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER, also interacts with Erg6p ergosterol biosynthetic process protein binding, bridging endoplasmic reticulum membrane
YDL155W YDL155W CLB3 hom Verified 0.20971032787699 0.416946882147453 no 2017 0.419945508808751 1381 NA FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION NUCLEUS B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress G2/M transition of mitotic cell cycle|S phase of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|positive regulation of spindle pole body separation cyclin-dependent protein kinase regulator activity nucleus|cytoplasm
YER066C-A_d YER066C-A YER066C-A hom Dubious 0.208142302387931 0.417558928930697 no 2018 0.40634442535532 1347 NA Dubious open reading frame unlikely to encode a protein, partially overlaps uncharacterized ORF YER067W Unknown Unknown Unknown
YFR032C_p YFR032C RRT5 hom Uncharacterized 0.208138438975285 0.417560437182385 no 2019 0.416457609271023 1389 NA Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; expressed at high levels during sporulation biological_process molecular_function cellular_component
YGL133W YGL133W ITC1 hom Verified 0.207532416734156 0.417797039407619 no 2020 0.408280928377307 1320 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS Subunit of the ATP-dependent Isw2p-Itc1p chromatin remodeling complex, required for repression of a-specific genes, repression of early meiotic genes during mitotic growth, and repression of INO1; similar to mammalian Acf1p, the regulatory subunit of the mammalian ATP-utilizing chromatin assembly and modifying factor (ACF) complex negative regulation of transcription from RNA polymerase II promoter by pheromones|chromatin remodeling|chromatin silencing at telomere molecular_function chromatin accessibility complex
YGR043C YGR043C NQM1 hom Verified 0.207483850718034 0.417816001762344 no 2021 0.415386076380392 1380 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS NUCLEUS Transaldolase of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift biological_process sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity nucleus
YGR038W YGR038W ORM1 hom Verified 0.20672821453663 0.418111060665601 no 2022 0.431557790552283 1425 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Evolutionarily conserved protein, similar to Orm2p, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control cellular sphingolipid homeostasis|negative regulation of sphingolipid biosynthetic process|response to unfolded protein molecular_function integral to membrane|endoplasmic reticulum|SPOTS complex
YDR305C YDR305C HNT2 hom Verified 0.206341591849089 0.418262045949971 no 2023 0.410792838484689 1335 NA FT NUCLEUS|MITOCHONDRION Dinucleoside triphosphate hydrolase; has similarity to the tumor suppressor FHIT and belongs to the histidine triad (HIT) superfamily of nucleotide-binding proteins nucleoside catabolic process hydrolase activity|nucleoside-triphosphatase activity mitochondrion|nucleus|cytoplasm
YPL118W YPL118W MRP51 hom Verified 0.205958818790404 0.418411539729709 no 2024 0.433903961969931 1439 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit; MRP51 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences mitochondrial translational initiation|mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YIL165C_p YIL165C YIL165C hom Uncharacterized 0.205054116024362 0.418764922369224 no 2025 0.407448754111991 1336 NA Putative protein of unknown function; mutant exhibits mitophagy defects; in closely related species and other S. cerevisiae strain backgrounds YIL165C and adjacent ORF, YIL164C, likely constitute a single ORF encoding a nitrilase gene mitochondrion degradation molecular_function cellular_component
YLR309C YLR309C IMH1 hom Verified 0.204567050989576 0.418955200229352 no 2026 0.40421458432035 1344 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Protein involved in vesicular transport, mediates transport between an endosomal compartment and the Golgi, contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi Golgi to plasma membrane protein transport|vesicle-mediated transport molecular_function cytosol|Golgi apparatus
YLR113W YLR113W HOG1 hom Verified 0.203327393231629 0.419439572996129 no 2027 0.446099862933625 1471 NA FT TRANSCRIPTION FROM RNA POL II|SIGNALING|PROTEIN PHOSPHORYLATION NUCLEUS Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNA Pol II in response to osmotic shock; acts via three independent osmosensors; mitophagy-specific regulator; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p; protein abundance increases in response to DNA replication stress negative regulation of transcription from RNA polymerase II promoter by pheromones|protein phosphorylation|hyperosmotic response|response to arsenic-containing substance|osmosensory signaling pathway|positive regulation of transcription from RNA polymerase II promoter|cellular response to heat MAP kinase activity nucleus|cytoplasm
YPL132W YPL132W COX11 hom Verified 0.202929834070741 0.419594937594005 no 2028 0.421915883359741 1372 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION RIBOSOME Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p protein complex assembly|aerobic respiration copper ion binding mitochondrial envelope|mitochondrion|mitochondrial ribosome|mitochondrial inner membrane
YDR504C YDR504C SPG3 hom Verified 0.202069068358388 0.419931364457132 no 2029 0.412343515566829 1363 NA Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources biological_process molecular_function cellular_component
YLR345W_p YLR345W YLR345W hom Uncharacterized 0.201866593578619 0.420010509432129 no 2030 0.411676890142498 1347 NA FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Similar to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase enzymes responsible for the metabolism of fructoso-2,6-bisphosphate; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene regulation of glycolysis|fructose 2,6-bisphosphate metabolic process 6-phosphofructo-2-kinase activity cytoplasm
YCL063W YCL063W VAC17 hom Verified 0.20072992216976 0.420454880687792 no 2031 0.411678330389816 1347 NA Phosphoprotein involved in vacuole inheritance; degraded in late M phase of the cell cycle; acts as a vacuole-specific receptor for myosin Myo2p vacuole inheritance protein anchor fungal-type vacuole membrane
YMR271C YMR271C URA10 hom Verified 0.19872379991077 0.421239402840371 no 2032 0.405303109189799 1327 NA FT NUCLEOTIDE METABOLISM Minor orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA10 has a paralog, URA5, that arose from the whole genome duplication 'de novo' pyrimidine nucleobase biosynthetic process|pyrimidine ribonucleoside biosynthetic process orotate phosphoribosyltransferase activity cytoplasm
YLR059C YLR059C REX2 hom Verified 0.198610064498931 0.421283890061991 no 2033 0.424024678771425 1404 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION 3'-5' RNA exonuclease; involved in 3'-end processing of U4 and U5 snRNAs, 5S and 5.8S rRNAs, and RNase P and RNase MRP RNA; localized to mitochondria and null suppresses escape of mtDNA to nucleus in yme1 yme2 mutants; RNase D exonuclease U5 snRNA 3'-end processing|U4 snRNA 3'-end processing|mitochondrial genome maintenance|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 3'-5'-exoribonuclease activity|3'-5' exonuclease activity mitochondrion
YJR036C YJR036C HUL4 hom Verified 0.198477858681298 0.421335603183306 no 2034 0.426541625490821 1408 NA FT PROTEOLYSIS NUCLEUS Protein with similarity to hect domain E3 ubiquitin-protein ligases; not essential for viability; found in association with Trf4 in TRAMP complex protein ubiquitination ubiquitin-protein ligase activity TRAMP complex
YPR097W YPR097W YPR097W hom Verified 0.196804716699388 0.421990179956796 no 2035 0.436976961528669 1458 NA FT MITOCHONDRION Protein that contains a Phox homology (PX) domain and binds phosphoinositides; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process phosphatidylinositol binding mitochondrion
YDR099W YDR099W BMH2 hom Verified 0.196634797978031 0.422056668679323 no 2036 0.429659431754983 1406 NA FT CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS 14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress glycogen metabolic process|ascospore formation|Ras protein signal transduction|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|DNA damage checkpoint|DNA replication initiation|signal transduction involved in filamentous growth|pseudohyphal growth|fungal-type cell wall chitin biosynthetic process|pre-replicative complex assembly DNA replication origin binding|phosphoserine binding nucleus|plasma membrane
YKL071W_p YKL071W YKL071W hom Uncharacterized 0.196438592384336 0.422133446145341 no 2037 0.424530231602381 1402 NA FT OXIDATION-REDUCTION PROCESS Putative protein of unknown function; expression induced in cells treated with the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm biological_process molecular_function integral to membrane|cytoplasm
YMR305C YMR305C SCW10 hom Verified 0.196295913263779 0.422189279956114 no 2038 0.428708222308695 1422 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM ENDOPLASMIC RETICULUM Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p conjugation with cellular fusion glucosidase activity fungal-type cell wall|extracellular region|endoplasmic reticulum|cytoplasm
YFL036W YFL036W RPO41 hom Verified 0.195706070728413 0.422420116272087 no 2039 0.427536589168409 1412 NA FT MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation transcription from mitochondrial promoter|mitochondrial genome maintenance DNA-directed RNA polymerase activity mitochondrial nucleoid|mitochondrion|mitochondrial DNA-directed RNA polymerase complex|mitochondrial matrix
YMR247W-A_p YMR247W-A YMR247W-A hom Uncharacterized 0.195541801357987 0.422484408238644 no 2040 0.415731284173823 1366 NA Putative protein of unknown function biological_process molecular_function cellular_component
YDR242W YDR242W AMD2 hom Verified 0.19529376388125 0.422581489391884 no 2041 0.383011535947018 1231 NA Putative amidase biological_process amidase activity cellular_component
YJR087W_d YJR087W YJR087W hom Dubious 0.195177815113818 0.42262687301851 no 2042 0.422047259133871 1409 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified genes STE18 and ECM2 Unknown Unknown Unknown
YNL146C-A_p YNL146C-A YNL146C-A hom Uncharacterized 0.195055495909659 0.422674751217598 no 2043 0.410850230224184 1377 NA Putative protein of unknown function biological_process molecular_function cellular_component
YCR016W_p YCR016W YCR016W hom Uncharacterized 0.194816255022551 0.422768398218788 no 2044 0.393245650812509 1313 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus and nucleus; predicted to be involved in ribosome biogenesis biological_process molecular_function nucleolus|nucleus
YML032C YML032C RAD52 hom Verified 0.193533834890614 0.423270455252709 no 2045 0.430583062789047 1420 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis postreplication repair|telomere maintenance via recombination|meiotic joint molecule formation|meiotic DNA recombinase assembly|DNA recombinase assembly|DNA strand renaturation|double-strand break repair via synthesis-dependent strand annealing|double-strand break repair via single-strand annealing|double-strand break repair via break-induced replication recombinase activity nuclear chromosome|nucleus
YER184C_p YER184C YER184C hom Uncharacterized 0.192945432728288 0.42350085166073 no 2046 0.433279182891588 1428 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Putative zinc cluster protein; deletion confers sensitivity to Calcufluor white, and prevents growth on glycerol or lactate as sole carbon source biological_process sequence-specific DNA binding cellular_component
YPR098C YPR098C YPR098C hom Verified 0.192860504420348 0.423534108590299 no 2047 0.433737404495454 1439 NA FT MITOCHONDRION Protein of unknown function, localized to the mitochondrial outer membrane biological_process molecular_function mitochondrial outer membrane|mitochondrion
YIR024C YIR024C YIR024C hom Verified 0.192083621663653 0.423838352021577 no 2048 0.431891406852649 1413 NA FT MITOCHONDRION Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; interacts with Arh1p, a mitochondrial oxidoreductase; deletion mutant has a respiratory growth defect biological_process molecular_function mitochondrion
YPL086C YPL086C ELP3 hom Verified 0.191557334868986 0.424044482675254 no 2049 0.413052455694048 1393 NA FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|CHROMATIN ORGANIZATION NUCLEUS Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin regulation of transcription from RNA polymerase II promoter|tRNA wobble uridine modification histone acetyltransferase activity Elongator holoenzyme complex|nucleus|cytoplasm
YKR098C YKR098C UBP11 hom Verified 0.191538867412276 0.424051716198419 no 2050 0.425699649179691 1420 NA FT PROTEOLYSIS Ubiquitin-specific protease that cleaves ubiquitin from ubiquitinated proteins biological_process ubiquitin-specific protease activity cellular_component
YHL016C YHL016C DUR3 hom Verified 0.191476316963999 0.424076216790683 no 2051 0.409528492338767 1344 NA FT PLASMA MEMBRANE Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway urea transport|spermidine transport|putrescine transport|urea catabolic process urea transmembrane transporter activity|spermidine transmembrane transporter activity|putrescine transmembrane transporter activity integral to membrane|plasma membrane
YMR018W_p YMR018W YMR018W hom Uncharacterized 0.191288180930893 0.424149910184887 no 2052 0.43472828772484 1417 NA FT PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION Putative protein of unknown function with similarity to human PEX5Rp (peroxin protein 5 related protein); transcription increases during colony development similar to genes involved in peroxisome biogenesis; YMR018W is not an essential gene biological_process molecular_function cellular_component
YMR205C YMR205C PFK2 hom Verified 0.191283007271885 0.424151936758627 no 2053 0.45113941108047 1873 NA FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes proton transport|glycolysis mRNA binding|6-phosphofructokinase activity mitochondrion|6-phosphofructokinase complex|cytoplasm
YPL064C YPL064C CWC27 hom Verified 0.191103866823736 0.424222109092223 no 2054 0.437101906480007 1437 NA FT RNA PROCESSING NUCLEUS Component of a complex containing Cef1p; putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p; protein abundance increases in response to DNA replication stress biological_process molecular_function U2-type spliceosomal complex
YMR192W YMR192W GYL1 hom Verified 0.190041729077396 0.424638215628328 no 2055 0.422774365847906 1380 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM MITOCHONDRION|GOLGI APPARATUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Putative GTPase activating protein (GAP) with a role in exocytosis; stimulates Gyp5p GAP activity on Ypt1p, colocalizes with Gyp5p at sites of polarized growth; interacts with Gyp5p, Rvs161p, and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; increases in abundance and relocalizes from bud neck to cytoplasm upon DNA replication stress ER to Golgi vesicle-mediated transport|regulation of exocytosis protein binding mitochondrion|incipient cellular bud site|cellular bud|cellular bud neck|cellular bud tip|cytoplasm|Golgi-associated vesicle|plasma membrane
YOR245C YOR245C DGA1 hom Verified 0.188795225359667 0.425126657079559 no 2056 0.435868317929041 1441 NA FT LIPID METABOLISM|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Diacylglycerol acyltransferase, catalyzes the terminal step of triacylglycerol (TAG) formation, acylates diacylglycerol using acyl-CoA as an acyl donor, localized to lipid particles lipid storage|triglyceride biosynthetic process diacylglycerol O-acyltransferase activity integral to membrane|lipid particle
YMR115W YMR115W MGR3 hom Verified 0.188372276059342 0.425292415571066 no 2057 0.423112034208856 1397 NA FT PROTEOLYSIS MITOCHONDRION Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA misfolded or incompletely synthesized protein catabolic process misfolded protein binding mitochondrion|mitochondrial inner membrane|i-AAA complex
YFL028C YFL028C CAF16 hom Verified 0.187703430284089 0.425554570545664 no 2058 0.419223011860936 1354 NA FT TRANSCRIPTION FROM RNA POL II|NUCLEOTIDE METABOLISM NUCLEUS Part of evolutionarily-conserved CCR4-NOT regulatory complex; contains single ABC-type ATPase domain but no transmembrane domain; interacts with several subunits of Mediator regulation of transcription from RNA polymerase II promoter ATPase activity CCR4-NOT complex|cytoplasm
YLR177W_p YLR177W YLR177W hom Uncharacterized 0.186362708208708 0.426080167314751 no 2059 0.427984201049066 1404 NA Putative protein of unknown function; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; not an essential gene; YLR177W has a paralog, PSP1, that arose from the whole genome duplication biological_process molecular_function cytoplasm
YPL070W YPL070W MUK1 hom Verified 0.186076795855191 0.42619226916924 no 2060 0.424254659608785 1381 NA Cytoplasmic protein of unknown function containing a Vps9 domain; computational analysis of large-scale protein-protein interaction data suggests a possible role in transcriptional regulation biological_process molecular_function cytoplasm
YKL029C YKL029C MAE1 hom Verified 0.185979065698714 0.426230589034862 no 2061 0.408967072778777 1366 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION Mitochondrial malic enzyme, catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids pyruvate metabolic process|cellular amino acid metabolic process malic enzyme activity mitochondrion
YER096W YER096W SHC1 hom Verified 0.184801248026886 0.426692464468398 no 2062 0.434883362520252 1427 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM Sporulation-specific activator of Chs3p (chitin synthase III); required for the synthesis of the chitosan layer of ascospores; transcriptionally induced at alkaline pH; SHC1 has a paralog, SKT5, that arose from the whole genome duplication ascospore formation|chitin biosynthetic process enzyme activator activity prospore membrane
YGL105W YGL105W ARC1 hom Verified 0.184389417990587 0.426853985356511 no 2063 0.434442159056977 1447 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p), delivering tRNA to them, stimulating catalysis, and ensuring their localization to the cytoplasm; also binds quadruplex nucleic acids; protein abundance increases in response to DNA replication stress positive regulation of ligase activity|tRNA aminoacylation for protein translation enzyme activator activity|tRNA binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding methionyl glutamyl tRNA synthetase complex|cytoplasm
YPL053C YPL053C KTR6 hom Verified 0.183675273282604 0.427134103963032 no 2064 0.431149877207657 1433 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM Probable mannosylphosphate transferase; involved in the synthesis of core oligosaccharides in protein glycosylation pathway; member of the KRE2/MNT1 mannosyltransferase family; KTR6 has a paralog, KRE2, that arose from the whole genome duplication fungal-type cell wall organization|protein N-linked glycosylation mannosylphosphate transferase activity membrane
YDL175C YDL175C AIR2 hom Verified 0.183136137748906 0.427345600710923 no 2065 0.431016900202319 1446 NA FT RNA PROCESSING NUCLEUS RNA-binding subunit of the TRAMP nuclear RNA surveillance complex; involved in nuclear RNA processing and degradation; involved in TRAMP complex assembly as a bridge between Mtr4p and Trf4p; stimulates the poly(A) polymerase activity of Pap2p in vitro; has 5 zinc knuckle motifs; AIR2 has a paralog, AIR1, that arose from the whole genome duplication nuclear polyadenylation-dependent CUT catabolic process|nuclear mRNA surveillance of mRNA 3'-end processing|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent snRNA catabolic process|ncRNA polyadenylation|tRNA modification polynucleotide adenylyltransferase activity|RNA binding|protein binding, bridging nucleolus|TRAMP complex
YMR255W YMR255W GFD1 hom Verified 0.183048571427805 0.427379953957302 no 2066 0.424592242224802 1420 NA FT PROTEIN LOCALIZATION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE Coiled-coiled protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; protein abundance increases in response to DNA replication stress mRNA export from nucleus molecular_function integral to membrane|nuclear pore|cytoplasm
YLR357W YLR357W RSC2 hom Verified 0.18303089468746 0.427386888806895 no 2067 0.437588213895043 1444 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS RSC COMPLEX Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenance ATP-dependent chromatin remodeling|chromosome segregation|nucleosome disassembly|plasmid maintenance|sister chromatid cohesion|double-strand break repair via nonhomologous end joining|transcription elongation from RNA polymerase II promoter|double-strand break repair via homologous recombination DNA translocase activity RSC complex
YGR040W YGR040W KSS1 hom Verified 0.182489826309348 0.427599168867457 no 2068 0.444701708149338 1481 NA FT CELL CYCLE|SIGNALING|PROTEIN PHOSPHORYLATION NUCLEUS Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains pheromone-dependent signal transduction involved in conjugation with cellular fusion|signal transduction involved in filamentous growth|negative regulation of sequence-specific DNA binding transcription factor activity|protein phosphorylation|invasive growth in response to glucose limitation MAP kinase activity|protein kinase activity|transcription factor binding nucleus
YDL227C YDL227C HO hom Verified 0.182349064329072 0.427654398156976 no 2069 0.416655928830882 1386 NA FT NUCLEUS Site-specific endonuclease required for gene conversion at the MAT locus (homothallic switching) through the generation of a ds DNA break; expression restricted to mother cells in late G1 as controlled by Swi4p-Swi6p, Swi5p and Ash1p mating type switching|gene conversion at mating-type locus, DNA double-strand break formation endonuclease activity nucleus
YNR027W YNR027W BUD17 hom Verified 0.18114919877691 0.428125234150837 no 2070 0.434617673517462 1462 NA FT CELL CYCLE|CELL DIVISION|COFACTOR METABOLISM NUCLEUS Putative pyridoxal kinase, a key enzyme in vitamin B6 metabolism; involved in bud-site selection; diploid mutants display a random rather than a bipolar budding pattern; similarity to yeast BUD16 and human pyridoxal kinase (PDXK) pyridoxal phosphate biosynthetic process|cellular bud site selection pyridoxal kinase activity nucleus|cytoplasm
YDR069C YDR069C DOA4 hom Verified 0.180275518440947 0.428468137119922 no 2071 0.444413167690517 1465 NA FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|PROTEOLYSIS MITOCHONDRION Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole protein deubiquitination|endocytosis|regulation of DNA replication|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|free ubiquitin chain depolymerization|ubiquitin homeostasis|ubiquitin-dependent protein catabolic process endopeptidase activity|ubiquitin-specific protease activity|ubiquitin thiolesterase activity endosome|proteasome complex|mitochondrion
YOR006C YOR006C TSR3 hom Verified 0.179943226685164 0.428598569526431 no 2072 0.446875628105432 1486 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Protein required for 20S pre-rRNA processing; involved in processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress maturation of SSU-rRNA molecular_function nucleus|cytoplasm
YBR134W_d YBR134W YBR134W hom Dubious 0.179083941826231 0.428935895369801 no 2073 0.426639999291452 1385 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YKR003W YKR003W OSH6 hom Verified 0.178826522833838 0.429036959377378 no 2074 0.405970665521189 1338 NA FT VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Member of an oxysterol-binding protein family; overlapping, redundant functions in sterol metabolism and which collectively perform a function essential for viability; GFP-fusion protein localizes to the cell periphery; overexpression extends lifespan by promoting vacuolar fusion sterol homeostasis|maintenance of cell polarity|endocytosis|sterol transport|exocytosis|sterol metabolic process phosphatidic acid binding|lipid binding|phosphatidylinositol-3,4-bisphosphate binding|oxysterol binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-5-phosphate binding|phosphatidylinositol-4-phosphate binding cortical endoplasmic reticulum|extrinsic to membrane|cytoplasm
YPL077C_p YPL077C YPL077C hom Uncharacterized 0.178328774632135 0.429232391046266 no 2075 0.431099584468537 1418 NA Putative protein of unknown function; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene; YPL077C has a paralog, YBR197C, that arose from the whole genome duplication biological_process molecular_function cellular_component
YDR051C YDR051C DET1 hom Verified 0.178070155140367 0.429333940080441 no 2076 0.426607607815351 1404 NA FT NUCLEUS Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel intracellular sterol transport|dephosphorylation acid phosphatase activity nucleus|cytoplasm
YBL015W YBL015W ACH1 hom Verified 0.177698412551695 0.429479916003976 no 2077 0.414059034614109 1370 NA FT KETONE METABOLISM|COFACTOR METABOLISM MITOCHONDRION Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth acetate metabolic process acetate CoA-transferase activity|acetyl-CoA hydrolase activity cytosol|mitochondrion
YJR117W YJR117W STE24 hom Verified 0.177295370233245 0.429638193603756 no 2078 0.421665894409958 1385 NA FT PROTEOLYSIS ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans CAAX-box protein processing|peptide pheromone maturation metalloendopeptidase activity mitochondrial outer membrane|integral to endoplasmic reticulum membrane|integral to membrane|nuclear inner membrane
YDR335W YDR335W MSN5 hom Verified 0.177066790697323 0.429727963449485 no 2079 0.441307709744519 1459 NA FT PROTEIN LOCALIZATION|RNA LOCALIZATION NUCLEUS Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm tRNA re-export from nucleus|protein export from nucleus protein binding|importin-alpha export receptor activity integral to membrane|nucleus|cytoplasm
YJR020W_d YJR020W YJR020W hom Dubious 0.175651604681576 0.430283828952517 no 2080 0.431022090298055 1427 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YNL058C_p YNL058C YNL058C hom Uncharacterized 0.174651649577149 0.430676680878645 no 2081 0.411593072333366 1363 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL058C is not an essential gene biological_process molecular_function fungal-type vacuole
YOR237W YOR237W HES1 hom Verified 0.173795515520836 0.431013084428507 no 2082 0.461697423660586 1546 NA FT VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION Protein implicated in the regulation of ergosterol biosynthesis; one of a seven member gene family with a common essential function and non-essential unique functions; similar to human oxysterol binding protein (OSBP); HES1 has a paralog, KES1, that arose from the whole genome duplication maintenance of cell polarity|endocytosis|exocytosis|sterol transport lipid binding|oxysterol binding|sterol transporter activity cellular_component
YGL249W YGL249W ZIP2 hom Verified 0.173257491738705 0.431224517498666 no 2083 0.4066026568521 1324 NA FT CELL CYCLE|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Meiosis-specific protein; involved in normal synaptonemal complex formation and pairing between homologous chromosomes during meiosis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress synaptonemal complex assembly|synapsis|reciprocal meiotic recombination molecular_function synaptonemal complex
YIL050W YIL050W PCL7 hom Verified 0.173027794527583 0.431314790122505 no 2084 0.381398387641649 1261 NA FT CELL CYCLE|OXIDATION-REDUCTION PROCESS|CELL DIVISION|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Pho85p cyclin of the Pho80p subfamily, forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism, expression is cell-cycle regulated regulation of glycogen catabolic process|regulation of cyclin-dependent protein kinase activity|regulation of protein stability|regulation of glycogen biosynthetic process cyclin-dependent protein kinase regulator activity cyclin-dependent protein kinase holoenzyme complex|nucleus
YLL056C_p YLL056C YLL056C hom Uncharacterized 0.172075711427981 0.431689003699873 no 2085 0.398537932841666 1289 NA Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p and genes involved in pleiotropic drug resistance (PDR); expression is induced in cells treated with the mycotoxin patulin biological_process molecular_function cellular_component
YLR388W YLR388W RPS29A hom Verified 0.171217667145536 0.432026308122371 no 2086 0.449305032254116 1511 NA FT TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29A has a paralog, RPS29B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic small ribosomal subunit
YMR081C YMR081C ISF1 hom Verified 0.170585290100929 0.432274932590705 no 2087 0.428183246756619 1428 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant aerobic respiration molecular_function cellular_component
YDR350C YDR350C ATP22 hom Verified 0.170182122180851 0.43243345552946 no 2088 0.440758185184769 1459 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Specific translational activator for the mitochondrial ATP6 mRNA, encoding a subunit of F1F0 ATP synthase; localized to the mitochondrial inner membrane proton-transporting ATP synthase complex biogenesis|positive regulation of mitochondrial translation translation regulator activity mitochondrial inner membrane
YJR060W YJR060W CBF1 hom Verified 0.167717868142683 0.433402619282896 no 2089 0.430439701936562 1420 NA FF|FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|CHROMOSOME SEGREGATION NUCLEUS|MITOCHONDRION|CHROMOSOME KINETOCHORE Dual function helix-loop-helix protein; binds the motif CACRTG present at several sites including MET gene promoters and centromere DNA element I (CDEI); affects nucleosome positioning at this motif; associates with other transcription factors such as Met4p and Isw1p to mediate transcriptional activation or repression; associates with kinetochore proteins and required for efficient chromosome segregation; protein abundance increases in response to DNA replication stress regulation of transcription from RNA polymerase II promoter in response to methionine|negative regulation of transcription from RNA polymerase II promoter|methionine biosynthetic process|chromosome segregation|Unknown|chromatin remodeling|negative regulation of ceramide biosynthetic process by negative regulation of transcription from RNA Polymerase II promoter RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor binding transcription factor activity|RNA polymerase II repressing transcription factor binding|centromeric DNA binding chromosome, centromeric region|mitochondrion|nucleus|kinetochore
YJL185C YJL185C ATG36 hom Verified 0.167464894568353 0.433502133753086 no 2090 0.427325550931279 1417 NA Pex3p interacting protein, required for pexophagy; interacts with Atg8p and Atg11p; mRNA is weakly cell cycle regulated, peaking in G2 phase; YJL185C is a non-essential gene peroxisome degradation molecular_function peroxisome
YHR026W YHR026W VMA16 hom Verified 0.166437688517963 0.433906258205187 no 2091 0.474777511351243 1772 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS Subunit c'' of the vacuolar ATPase, which functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domain vacuolar acidification proton-transporting ATPase activity, rotational mechanism vacuolar proton-transporting V-type ATPase, V0 domain|integral to membrane
YIL064W YIL064W SEE1 hom Verified 0.166341614287382 0.433944059366936 no 2092 0.428137468625573 1408 NA FT VESICLE-MEDIATED TRANSPORT Probable lysine methyltransferase involved in the dimethylation of eEF1A (Tef1p/Tef2p); sequence similarity to S-adenosylmethionine-dependent methyltransferases of the seven beta-strand family; role in vesicular transport vesicle-mediated transport|peptidyl-lysine dimethylation protein-lysine N-methyltransferase activity cytoplasm
YGL049C YGL049C TIF4632 hom Verified 0.166275734172979 0.433969980765343 no 2093 0.426776385361903 1436 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION RIBOSOME Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); TIF4632 has a paralog, TIF4631, that arose from the whole genome duplication translational initiation|stress granule assembly translation initiation factor binding|mRNA binding|translation initiation factor activity eukaryotic translation initiation factor 4F complex|cytoplasmic stress granule
YPR044C_d YPR044C OPI11 hom Dubious 0.163333624544681 0.435127880406152 no 2094 0.437662555571158 1449 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RPL43A/YPR043W; deletion confers sensitivity to GSAO Unknown Unknown Unknown
YAL047C YAL047C SPC72 hom Verified 0.162358314692237 0.435511847647974 no 2095 0.440800417629919 1472 NA FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION NUCLEUS|CYTOSKELETON Component of the cytoplasmic Tub4p (gamma-tubulin) complex, binds spindle pole bodies and links them to microtubules; has roles in astral microtubule formation and stabilization microtubule nucleation|nuclear migration along microtubule|mitotic cell cycle spindle orientation checkpoint|mitotic spindle elongation|mitotic sister chromatid segregation structural constituent of cytoskeleton outer plaque of spindle pole body
YJR097W YJR097W JJJ3 hom Verified 0.161198908929917 0.435968370214047 no 2096 0.440090701746212 1474 NA FT NUCLEUS Protein of unknown function, contains a CSL Zn finger and a DnaJ-domain; involved in diphthamide biosynthesis; ortholog human Dph4 peptidyl-diphthamide biosynthetic process from peptidyl-histidine ferrous iron binding nucleus|cytoplasm
YDL133W YDL133W SRF1 hom Verified 0.160028852574257 0.43642917301865 no 2097 0.485147934893518 1619 NA Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients positive regulation of catalytic activity molecular_function integral to membrane
YBR282W YBR282W MRPL27 hom Verified 0.159637771692845 0.436583211509717 no 2098 0.436902619936026 1446 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit; homolog of human Bcl-2 interacting protein BMRP mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YJR152W YJR152W DAL5 hom Verified 0.159354776639339 0.436694683277101 no 2099 0.430964808401289 1415 NA FT PLASMA MEMBRANE Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression dipeptide transport|allantoate transport dipeptide transporter activity|allantoate transmembrane transporter activity integral to membrane|plasma membrane
YGL262W_p YGL262W YGL262W hom Uncharacterized 0.158273532329588 0.437120631691959 no 2100 0.417103297590827 1387 NA Putative protein of unknown function; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein; YGL262W is not an essential gene biological_process molecular_function cellular_component
YJL082W YJL082W IML2 hom Verified 0.157352841042756 0.437483388884006 no 2101 0.414033478729944 1353 NA FT NUCLEUS|MITOCHONDRION Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; IML2 has a paralog, YKR018C, that arose from the whole genome duplication biological_process molecular_function mitochondrial outer membrane|mitochondrion|nucleus|cytoplasm
YBL071C-B_p YBL071C-B YBL071C-B hom Uncharacterized 0.155350359137522 0.43827255831181 no 2102 0.445667221569857 1483 NA Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YNL147W YNL147W LSM7 hom Verified 0.154146644176621 0.438747055509819 no 2103 0.414017093113624 1359 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress nuclear-transcribed mRNA catabolic process|mRNA splicing, via spliceosome|maturation of SSU-rRNA RNA binding U6 snRNP|nucleolus|small nucleolar ribonucleoprotein complex|U4/U6 x U5 tri-snRNP complex|cytoplasm
YKL204W YKL204W EAP1 hom Verified 0.153682790422926 0.438929927409226 no 2104 0.452444002140291 1488 NA FT TRANSLATION eIF4E-associated protein, competes with eIF4G for binding to eIF4E; accelerates mRNA degradation by promoting decapping, facilitated by interaction with eIF4E; essential for Puf5p mediated repression; associates with Puf5p and Dhh1p; inhibits cap-dependent translation; functions independently of eIF4E to maintain genetic stability; plays a role in cell growth, implicated in the TOR signaling cascade negative regulation of translation eukaryotic initiation factor 4E binding mRNA cap binding complex|cytoplasmic stress granule
YOL037C_d YOL037C YOL037C hom Dubious 0.152038744603839 0.439578188540412 no 2105 0.453259807800127 1501 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOL036W Unknown Unknown Unknown
YEL016C YEL016C NPP2 hom Verified 0.151712259455608 0.439706943728978 no 2106 0.443905838631491 1464 NA FT NUCLEOTIDE METABOLISM Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp1p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; NPP2 has a paralog, NPP1, that arose from the whole genome duplication nucleoside triphosphate metabolic process nucleotide diphosphatase activity|nucleoside-triphosphate diphosphatase activity|nucleoside-triphosphatase activity|phosphodiesterase I activity cellular_component
YGR028W YGR028W MSP1 hom Verified 0.149861313951319 0.440437016978327 no 2107 0.437726343980694 1449 NA FT PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial protein involved in sorting of proteins in the mitochondria; putative membrane-spanning ATPase protein targeting to mitochondrion ATPase activity mitochondrial outer membrane|mitochondrion
YNL100W YNL100W AIM37 hom Verified 0.149545024336982 0.440561792243207 no 2108 0.470337883822887 1556 NA FT MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial inner membrane protein; component of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture cristae formation molecular_function mitochondrion|mitochondrial crista junction|integral to mitochondrial inner membrane
YDL027C_p YDL027C YDL027C hom Uncharacterized 0.14949594415875 0.440581154749493 no 2109 0.444504658470777 1464 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL027C is not an essential gene biological_process molecular_function mitochondrion
YHR030C YHR030C SLT2 hom Verified 0.148798035050897 0.440856500590445 no 2110 0.468702439155468 1561 NA FF|FT PROTEIN LOCALIZATION|RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|CELL DIVISION|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION NUCLEUS|SITE OF POLARIZED GROWTH Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, progression through the cell cycle, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to the phagophore assembly site (PAS); regulated by the PKC1-mediated signaling pathway protein phosphorylation|endoplasmic reticulum unfolded protein response|signal transduction|UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response|fungal-type cell wall organization|peroxisome degradation|regulation of transcription factor import into nucleus|barrier septum assembly|response to acid|regulation of cell size MAP kinase activity|protein serine/threonine kinase activity|protein kinase activity nucleus|cytoplasm|cellular bud tip
YOR139C_d YOR139C YOR139C hom Dubious 0.148643125158066 0.440917621019923 no 2111 0.462863201593561 1530 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SFL1/YOR140W Unknown Unknown Unknown
YJL047C YJL047C RTT101 hom Verified 0.148617691972946 0.440927655937711 no 2112 0.45150271538186 1485 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEOLYSIS NUCLEUS UBIQUITIN LIGASE COMPLEX Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex with a role in anaphase progression; implicated in Mms22-dependent DNA repair; involved with Mms1p in nonfunctional rRNA decay; modified by the ubiquitin-like protein, Rub1p replication fork processing|negative regulation of transposition, RNA-mediated|regulation of mitosis|nonfunctional rRNA decay|ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity Cul8-RING ubiquitin ligase complex|nucleus|cytoplasm
YKL131W_d YKL131W YKL131W hom Dubious 0.14830216484566 0.441052153476599 no 2113 0.427657782109426 1421 NA Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDL050C_d YDL050C YDL050C hom Dubious 0.147925499158666 0.441200782084444 no 2114 0.439596489793203 1449 NA Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOL159C YOL159C YOL159C hom Verified 0.146868409089189 0.441617943687827 no 2115 0.434962047568372 1457 NA Soluble protein of unknown function; deletion mutants are viable and have elevated levels of Ty1 retrotransposition and Ty1 cDNA biological_process molecular_function cellular_component
YKL130C YKL130C SHE2 hom Verified 0.146797112420717 0.441646081973758 no 2116 0.429033020913461 1406 NA FT RNA LOCALIZATION NUCLEUS|SITE OF POLARIZED GROWTH RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud mating type switching|intracellular mRNA localization mRNA binding cellular bud tip|cytoplasm
YDR028C YDR028C REG1 hom Verified 0.146741268669454 0.441668121742773 no 2117 0.487436945052752 1621 NA FF|FT TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Regulatory subunit of type 1 protein phosphatase Glc7p; involved in negative regulation of glucose-repressible genes; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p cellular response to glucose starvation|vacuolar protein catabolic process|glycogen metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of carbohydrate metabolic process protein phosphatase type 1 regulator activity protein phosphatase type 1 complex|cytoplasm
YKR074W YKR074W AIM29 hom Verified 0.146128853537866 0.441909834534451 no 2118 0.419401883193242 1402 NA Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YKR074W is not an essential gene; null mutant displays elevated frequency of mitochondrial genome loss biological_process molecular_function cytoplasm
YIR017C YIR017C MET28 hom Verified 0.145239756499792 0.442260788779835 no 2119 0.454934307547792 1520 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Basic leucine zipper (bZIP) transcriptional activator in the Cbf1p-Met4p-Met28p complex, participates in the regulation of sulfur metabolism regulation of transcription from RNA polymerase II promoter|regulation of sulfur amino acid metabolic process|Unknown RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YDR415C_p YDR415C YDR415C hom Uncharacterized 0.144895477226314 0.442396698701385 no 2120 0.428699206517459 1407 NA FT PROTEOLYSIS Putative aminopeptidase biological_process molecular_function cellular_component
YDR315C YDR315C IPK1 hom Verified 0.144448680132592 0.44257308932993 no 2121 0.474425063079846 1577 NA FT NUCLEUS Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable nuclear-transcribed mRNA catabolic process, non-stop decay|inositol phosphate biosynthetic process inositol pentakisphosphate 2-kinase activity nucleus
YHR151C YHR151C MTC6 hom Verified 0.144400361733948 0.442592165590463 no 2122 0.451437120611281 1479 NA Protein of unknown function; mtc6 is synthetically sick with cdc13-1 biological_process molecular_function cellular_component
YMR041C YMR041C ARA2 hom Verified 0.143309630531672 0.443022825138577 no 2123 0.433599047332815 1421 NA FT OXIDATION-REDUCTION PROCESS NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase dehydro-D-arabinono-1,4-lactone biosynthetic process D-arabinose 1-dehydrogenase [NAD(P)+] activity cellular_component
YBL061C YBL061C SKT5 hom Verified 0.142805673037661 0.443221828285403 no 2124 0.446569209283471 1487 NA FT CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON Activator of Chs3p (chitin synthase III) during vegetative growth; recruits Chs3p to the bud neck via interaction with Bni4p; SKT5 has a paralog, SHC1, that arose from the whole genome duplication fungal-type cell wall chitin biosynthetic process|response to osmotic stress|cytokinesis enzyme activator activity incipient cellular bud site|cellular bud neck septin ring|cellular bud neck
YHR106W YHR106W TRR2 hom Verified 0.142270487383899 0.443433178513453 no 2125 0.396736690333189 1294 NA FT OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS MITOCHONDRION Mitochondrial thioredoxin reductase; involved in protection against oxidative stress, required with Glr1p to maintain the redox state of Trx3p; contains active-site motif (CAVC) present in prokaryotic orthologs; binds NADPH and FAD; TRR2 has a paralog, TRR1, that arose from the whole genome duplication cellular response to oxidative stress|cell redox homeostasis thioredoxin-disulfide reductase activity mitochondrion
YIL127C_p YIL127C RRT14 hom Uncharacterized 0.14142765920809 0.443766052490338 no 2126 0.433827045435055 1427 NA FT NUCLEUS Putative protein of unknown function; identified in a screen for mutants with decreased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis biological_process molecular_function nucleolus
YNL064C YNL064C YDJ1 hom Verified 0.140504037785985 0.444130881223075 no 2127 0.376608632534642 1271 NA FT PROTEIN LOCALIZATION|PROTEOLYSIS|MITOCHONDRION ORGANIZATION Type I HSP40 co-chaperone; involved in regulation of HSP90 and HSP70 functions; critical for determining cell size at Start as a function of growth rate; involved in protein translocation across membranes; member of the DnaJ family protein refolding|ER-associated protein catabolic process|protein targeting to mitochondrion|protein targeting to ER|'de novo' protein folding unfolded protein binding|ATPase activator activity cytosol|TRC complex|perinu