strainid orf gene zyg qualifier SGTC_2431|5490079.score SGTC_2431|5490079.expt.zyg.pval SGTC_2431|5490079.expt.zyg.significant SGTC_2431|5490079.expt.zyg.rank strain.pval strain.rank clearance Fclass Fterms.BP Fterms.CC Fterms.complex description GO_process GO_function GO_component
YJL204C YJL204C RCY1 hom Verified 7.8450181086554 2.16445508899242e-15 yes 1 5.12706379830155e-10 151 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION GOLGI APPARATUS|SITE OF POLARIZED GROWTH F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth early endosome to Golgi transport|endocytosis SNARE binding endosome|Golgi apparatus|site of polarized growth
YGL095C YGL095C VPS45 hom Verified 7.32446296605965 1.19928643784566e-13 yes 2 4.9422569656794e-07 28 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment vacuole inheritance|CVT pathway|positive regulation of SNARE complex assembly|Golgi vesicle fusion to target membrane|Golgi to vacuole transport|vacuole organization|vacuolar acidification|protein targeting to vacuole|Golgi to endosome transport unfolded protein binding|SNARE binding cytosol|SNARE complex|Golgi membrane|extrinsic to membrane
YNR032C-A YNR032C-A HUB1 hom Verified 7.11298684951641 5.67790515842049e-13 yes 3 5.10802765472348e-15 4 NA FT RNA PROCESSING Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear cellular protein modification process|cell morphogenesis involved in conjugation with cellular fusion|mRNA splicing, via spliceosome protein tag mating projection
YJR040W YJR040W GEF1 hom Verified 6.58815984051158 2.22655551150379e-11 yes 4 1.43128614195804e-10 26 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS ENDOPLASMIC RETICULUM|GOLGI APPARATUS|PLASMA MEMBRANE Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism cellular copper ion homeostasis|cellular iron ion homeostasis voltage-gated chloride channel activity endosome|integral to membrane|endoplasmic reticulum|Golgi apparatus|plasma membrane|fungal-type vacuole|Golgi medial cisterna
YIR005W YIR005W IST3 hom Verified 6.45377628833715 5.45484123713744e-11 yes 5 3.67710609514876e-11 2 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RNA LOCALIZATION NUCLEUS Component of the U2 snRNP, required for the first catalytic step of splicing and for spliceosomal assembly; interacts with Rds3p and is required for Mer1p-activated splicing mRNA export from nucleus|spliceosomal complex assembly|mRNA splicing, via spliceosome|generation of catalytic spliceosome for first transesterification step first spliceosomal transesterification activity RES complex|U2 snRNP
YKR019C YKR019C IRS4 hom Verified 6.31952905252234 1.31180811352884e-10 yes 6 0.00206305432746027 101 NA FF|FT LIPID METABOLISM|SIGNALING|CELL WALL ORG/BIOGENESIS|RESPONSE TO NUTRIENT LEVELS|GENE SILENCING MITOCHONDRION EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication autophagy|fungal-type cell wall organization|chromatin silencing at rDNA|inositol lipid-mediated signaling|CVT pathway|cellular response to starvation molecular_function mitochondrion|pre-autophagosomal structure
YDR484W YDR484W VPS52 hom Verified 5.89066207919439 1.92325698569968e-09 yes 7 3.2527305384522e-06 3 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT GOLGI APPARATUS|CYTOSKELETON Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin actin filament-based process|Golgi to vacuole transport|retrograde transport, endosome to Golgi protein binding Golgi apparatus|GARP complex
YMR247C YMR247C RKR1 hom Verified 5.78177776312464 3.69576564954528e-09 yes 8 2.00104011524969e-10 5 NA FT CHROMATIN ORGANIZATION|PROTEOLYSIS|GENE SILENCING NUCLEUS RING domain E3 ubiquitin ligase; involved in the ubiquitin-mediated degradation of non-stop proteins; functional connections to chromatin modification; nuclear protein that also co-localizes with ribosomes; homolog of mouse Listerin, whose mutation has been reported to cause neurodegeneration in mice chromatin modification|chromatin silencing at telomere|ubiquitin-dependent protein catabolic process|protein ubiquitination ubiquitin-protein ligase activity|ribosome binding ribosome|nucleus
YJL213W YJL213W YJL213W hom Verified 5.74731099560368 4.5336932280404e-09 yes 9 5.11842298554371e-10 2 NA Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p biological_process molecular_function ribosome
YPR053C_d YPR053C YPR053C hom Dubious 5.73972128442506 4.74162474725266e-09 yes 10 1.37818538795693e-09 1 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene NHP6A/YPR052C Unknown Unknown Unknown
YNL206C YNL206C RTT106 hom Verified 5.73308774021625 4.93092921728437e-09 yes 11 3.6670848537864e-08 4 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Histone chaperone, involved in regulation of chromatin structure in both transcribed and silenced chromosomal regions; affects transcriptional elongation; has a role in regulation of Ty1 transposition DNA replication-independent nucleosome assembly|negative regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|DNA replication-dependent nucleosome assembly|heterochromatin assembly involved in chromatin silencing double-stranded DNA binding|histone binding nucleus
YOL018C YOL018C TLG2 hom Verified 5.1708641545655 1.16506958814681e-07 yes 12 0.000963910523389126 59 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT GOLGI APPARATUS Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16) inositolphosphoceramide metabolic process|Golgi to vacuole transport|endocytosis|mannosyl-inositol phosphorylceramide metabolic process|protein exit from endoplasmic reticulum|vesicle fusion|CVT pathway SNAP receptor activity SNARE complex|trans-Golgi network|integral to endosome membrane
YHL026C_p YHL026C YHL026C hom Uncharacterized 4.99870363738896 2.8858515873496e-07 yes 13 5.19461920223901e-07 4 NA Putative protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History) biological_process molecular_function cellular_component
YER059W YER059W PCL6 hom Verified 4.9913037464817 2.99865494195896e-07 yes 14 2.6132753909543e-08 4 NA FT CELL CYCLE|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Pho85p cyclin of the Pho80p subfamily; forms the major Glc8p kinase together with Pcl7p and Pho85p; involved in the control of glycogen storage by Pho85p; stabilized by Elongin C binding regulation of glycogen catabolic process|regulation of glycogen biosynthetic process cyclin-dependent protein kinase regulator activity cyclin-dependent protein kinase holoenzyme complex
YDL144C YDL144C YDL144C hom Verified 4.81879701516617 7.2213199178686e-07 yes 15 1.99007233464423e-06 6 NA FT OXIDATION-REDUCTION PROCESS NUCLEUS Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDL144C is not an essential gene; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus|cytoplasm
YCR094W YCR094W CDC50 hom Verified 4.6447862589197 1.70214359918521e-06 yes 16 7.42405417842875e-05 153 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION GOLGI APPARATUS Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Lem3p; CDC50 has a paralog, YNR048W, that arose from the whole genome duplication intracellular protein transport|phospholipid translocation|endocytosis|actin cortical patch localization phospholipid-translocating ATPase activity trans-Golgi network|late endosome membrane
YBR284W_p YBR284W YBR284W hom Uncharacterized 4.62289483543154 1.89210798434643e-06 yes 17 2.28006879410035e-06 9 NA FT NUCLEOTIDE METABOLISM Putative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic defect of quadruple aah1 ade8 amd1 his1 mutant; null mutant exhibits longer telomeres, altered Ty mobility, decreased resistance to rapamycin and wortmannin; induced in response to hydrostatic pressure; not an essential gene; YBR284W has a paralog, YJL070C, that arose from the whole genome duplication biological_process AMP deaminase activity|molecular_function cellular_component
YBR297W YBR297W MAL33 hom Verified 4.52416173266078 3.03176726855407e-06 yes 18 2.92313525122478e-06 6 NA FT TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM NUCLEUS MAL-activator protein, part of complex locus MAL3; nonfunctional in genomic reference strain S288C cellular carbohydrate metabolic process|regulation of transcription, DNA-dependent sequence-specific DNA binding transcription factor activity nucleus
YGL246C YGL246C RAI1 hom Verified 4.49592625428915 3.46338713012277e-06 yes 19 7.08252310219082e-06 17 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z deadenylation-dependent decapping of nuclear-transcribed mRNA|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|termination of RNA polymerase II transcription, poly(A)-coupled|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) enzyme regulator activity|m7G(5')pppN diphosphatase activity nucleus
YMR189W YMR189W GCV2 hom Verified 4.45228956618642 4.24797435636942e-06 yes 20 3.30577960188772e-07 6 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION P subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of 5,10-methylene-THF in the cytoplasm glycine decarboxylation via glycine cleavage system|one-carbon metabolic process glycine dehydrogenase (decarboxylating) activity mitochondrion|glycine cleavage complex
YMR242W-A_p YMR242W-A YMR242W-A hom Uncharacterized 4.36924203248677 6.23392618922725e-06 yes 21 6.54845140664607e-06 12 NA Putative protein of unknown function biological_process molecular_function cellular_component
YIR042C_p YIR042C YIR042C hom Uncharacterized 4.2936495934663 8.78798975230695e-06 yes 22 3.02100209602909e-06 7 NA Putative protein of unknown function; YIR042C is a non-essential gene biological_process molecular_function cellular_component
YDR128W YDR128W MTC5 hom Verified 4.26514587381469 9.98858186483031e-06 yes 23 1.0509773340986e-06 7 NA Subunit of the SEA (Seh1-associated) complex; SEA is a coatomer-related complex that associates dynamically with the vacuole; has N-terminal WD-40 repeats and a C-terminal RING motif; mtc5 is synthetically sick with cdc13-1; relative distribution to vacuolar membrane punctae decreases upon DNA replication stress biological_process molecular_function fungal-type vacuole membrane|Seh1-associated complex|extrinsic to fungal-type vacuolar membrane
YHR064C YHR064C SSZ1 hom Verified 4.24038915345122 1.1156630174479e-05 yes 24 1.17011354640573e-05 24 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP cytoplasmic translation|regulation of translational fidelity|rRNA processing unfolded protein binding polysome|cytoplasm
YBR009C YBR009C HHF1 hom Verified 4.23433257211333 1.14615747083381e-05 yes 25 2.998976673466e-05 17 NA FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Histone H4, core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity chromatin assembly or disassembly|sexual sporulation resulting in formation of a cellular spore|histone H3-K79 methylation DNA binding replication fork protection complex|nuclear nucleosome
YCR004C YCR004C YCP4 hom Verified 4.19187542026226 1.38328955967341e-05 yes 26 8.16942102415244e-06 11 NA FT OXIDATION-REDUCTION PROCESS MITOCHONDRION Protein of unknown function, has sequence and structural similarity to flavodoxins; predicted to be palmitoylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process electron carrier activity mitochondrion|membrane raft|plasma membrane|cytoplasm
YKL041W YKL041W VPS24 hom Verified 4.1889287711692 1.40137173536844e-05 yes 27 4.33563410702992e-05 25 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); forms an ESCRT-III subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway intralumenal vesicle formation|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|late endosome to vacuole transport molecular_function ESCRT III complex|cytoplasm
YLR240W YLR240W VPS34 hom Verified 4.1201031714672 1.89351392203711e-05 yes 28 1.94918183763664e-05 15 NA FT PROTEIN LOCALIZATION|LIPID METABOLISM|SIGNALING|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION GOLGI APPARATUS Phosphatidylinositol (PI) 3-kinase that synthesizes PI-3-phosphate; forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting; activated by the GTP-bound form of Gpa1p; a fraction is localized, with Vps15p, to nuclear pores at nucleus-vacuole junctions and may facilitate transcription elongation for genes positioned at the nuclear periphery peroxisome degradation|phosphatidylinositol phosphorylation|protein phosphorylation 1-phosphatidylinositol-3-kinase activity|protein kinase activity endosome|fungal-type vacuole membrane|phosphatidylinositol 3-kinase complex I|phosphatidylinositol 3-kinase complex II|peroxisome|pre-autophagosomal structure
YMR233W YMR233W TRI1 hom Verified 4.10745653043776 2.00020018007312e-05 yes 29 4.57334730009747e-05 18 NA FT NUCLEUS Non-essential sumoylated protein of unknown function; similar to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus; TRI1 has a paralog, UAF30, that arose from the whole genome duplication biological_process molecular_function nucleolus|nucleus|cytoplasm
YMR060C YMR060C SAM37 hom Verified 4.06713389835587 2.37974491075578e-05 yes 30 0.000211043594739541 21 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; contributes to SAM complex stability mitochondrial outer membrane translocase complex assembly|protein import into mitochondrial outer membrane|phospholipid transport molecular_function mitochondrial outer membrane|mitochondrial sorting and assembly machinery complex|mitochondrion|integral to membrane
YML013W YML013W UBX2 hom Verified 4.04440671766361 2.6227894213642e-05 yes 31 0.000196286232791517 51 NA FF|FT PROTEOLYSIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION UBIQUITIN LIGASE COMPLEX Bridging factor involved in ER-associated protein degradation (ERAD); bridges the cytosolic Cdc48p-Npl1p-Ufd1p ATPase complex and the membrane associated Ssm4p and Hrd1p ubiquitin ligase complexes; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain; redistributes from the ER to lipid droplets during the diauxic shift and stationary phase; required for the maintenance of lipid homeostasis proteasomal ubiquitin-dependent protein catabolic process|ER-associated protein catabolic process|lipid particle organization protein binding, bridging mitochondrial outer membrane|Doa10p ubiquitin ligase complex|integral to endoplasmic reticulum membrane|lipid particle|endoplasmic reticulum
YDR032C YDR032C PST2 hom Verified 4.01233641197948 3.0060370008018e-05 yes 32 1.75066480257147e-05 13 NA FT OXIDATION-REDUCTION PROCESS MITOCHONDRION Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication biological_process molecular_function mitochondrion|membrane raft|plasma membrane|cytoplasm
YOR189W YOR189W IES4 hom Verified 3.99285347283769 3.2641456236574e-05 yes 33 5.89095180284847e-05 8 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Component of the INO80 chromatiin remodeling complex and target of the Mec1p/Tel1p DNA damage signaling pathway; proposed to link chromatin remodeling to replication checkpoint responses response to DNA damage stimulus molecular_function nucleus|Ino80 complex
YLR422W_p YLR422W YLR422W hom Uncharacterized 3.98559830239346 3.36551514112866e-05 yes 34 7.51595171672886e-05 11 NA Protein of unknown function with similarity to human DOCK proteins (guanine nucleotide exchange factors); interacts with Ino4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, YLR422W is not an essential protein biological_process molecular_function cytoplasm
YIL043C YIL043C CBR1 hom Verified 3.98251664805148 3.40946732929971e-05 yes 35 6.53009964253106e-05 28 NA FT OXIDATION-REDUCTION PROCESS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION Microsomal cytochrome b reductase, not essential for viability; also detected in mitochondria; mutation in conserved NADH binding domain of the human ortholog results in type I methemoglobinemia biological_process cytochrome-b5 reductase activity mitochondrial outer membrane|mitochondrion
YMR319C YMR319C FET4 hom Verified 3.97175362646487 3.56727433973121e-05 yes 36 0.0012676714183584 75 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Low-affinity Fe(II) transporter of the plasma membrane intracellular copper ion transport|zinc ion transport|low-affinity iron ion transport|copper ion import copper ion transmembrane transporter activity|iron ion transmembrane transporter activity integral to membrane|plasma membrane|integral to plasma membrane
YOR386W YOR386W PHR1 hom Verified 3.93317815325038 4.19150294888797e-05 yes 37 6.50441887240911e-05 16 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION DNA photolyase involved in photoreactivation, repairs pyrimidine dimers in the presence of visible light; induced by DNA damage; regulated by transcriptional repressor Rph1p photoreactive repair mRNA binding|deoxyribodipyrimidine photo-lyase activity mitochondrion|nucleus
YGL084C YGL084C GUP1 hom Verified 3.92551213262991 4.32727037505293e-05 yes 38 0.00219626228078395 78 NA FF|FT LIPID METABOLISM|CARBOHYDRATE METABOLISM ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; proposed to be involved in glycerol transport GPI anchor biosynthetic process|glycerol transport|glycerol catabolic process O-acyltransferase activity integral to membrane|endoplasmic reticulum|plasma membrane|membrane
YER170W YER170W ADK2 hom Verified 3.88605294232665 5.09436477502929e-05 yes 39 7.21399293231252e-05 12 NA FT NUCLEOTIDE METABOLISM MITOCHONDRION Mitochondrial adenylate kinase, catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background nucleotide metabolic process nucleoside triphosphate adenylate kinase activity|adenylate kinase activity mitochondrion|mitochondrial inner membrane
YER076C_p YER076C YER076C hom Uncharacterized 3.8589639624792 5.69343627971602e-05 yes 40 3.96922513274708e-05 9 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; analysis of HA-tagged protein suggests a membrane localization biological_process molecular_function mitochondrion
YNR018W YNR018W RCF2 hom Verified 3.84186000468342 6.10527388724761e-05 yes 41 2.56357159704447e-05 16 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast mitochondrial respiratory chain complex IV assembly molecular_function mitochondrion|mitochondrial respiratory chain supercomplex|mitochondrial respiratory chain complex IV|integral to mitochondrial inner membrane
YFR049W YFR049W YMR31 hom Verified 3.82373883241735 6.57215728352241e-05 yes 42 0.000161219629747776 21 NA FT TRANSLATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit, has similarity to human mitochondrial ribosomal protein MRP-S36 cytoplasmic translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YMR273C YMR273C ZDS1 hom Verified 3.79854618743587 7.27736544417491e-05 yes 43 0.000160671037242105 24 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CELL WALL ORG/BIOGENESIS|RNA LOCALIZATION|GENE SILENCING ENDOMEMBRANE SYSTEM|NUCLEUS|SITE OF POLARIZED GROWTH NUCLEAR PORE Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintaining Cdc55p in the cytoplasm where it promotes mitotic entry; involved in mitotic exit through Cdc14p regulation; interacts with silencing proteins at telomeres; has a role in Bcy1p localization; implicated in mRNA nuclear export; ZDS1 has a paralog, ZDS2, that arose from the whole genome duplication mRNA export from nucleus|positive regulation of G2/M transition of mitotic cell cycle|cell shape checkpoint|chromatin silencing|establishment of cell polarity|regulation of protein localization|cell aging protein phosphatase type 2A regulator activity incipient cellular bud site|nuclear pore|cellular bud neck|cellular bud tip|cytoplasm
YLR148W YLR148W PEP3 hom Verified 3.78021960674241 7.83450458349089e-05 yes 44 0.00240089106575619 80 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT Component of CORVET tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis regulation of SNARE complex assembly|regulation of vacuole fusion, non-autophagic|vacuole fusion, non-autophagic|late endosome to vacuole transport|vesicle docking involved in exocytosis|Golgi to endosome transport phosphatidylinositol binding|protein binding, bridging fungal-type vacuole membrane|HOPS complex|proteasome storage granule|CORVET complex|extrinsic to vacuolar membrane
YIL072W YIL072W HOP1 hom Verified 3.69591016837549 0.000109550219503768 yes 45 0.000647262647055586 39 NA FT CELL CYCLE NUCLEUS|CHROMOSOME Meiosis-specific protein required for chromosome synapsis; displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex; required for chiasma formation; in vitro, displays the ability to promote intra- and intermolecular synapsis between double-stranded DNA molecules and to fold DNA into rigid protein?DNA filaments synaptonemal complex assembly|meiotic recombination checkpoint|synapsis four-way junction DNA binding condensed nuclear chromosome|lateral element
YMR057C_d YMR057C YMR057C hom Dubious 3.63864336597265 0.000137039018464107 yes 46 8.6455451484312e-05 23 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF AAC1 Unknown Unknown Unknown
YAL064C-A_p YAL064C-A TDA8 hom Uncharacterized 3.62737200682211 0.000143160314308494 yes 47 8.7648728093569e-05 26 NA Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene biological_process molecular_function cellular_component
YJR044C YJR044C VPS55 hom Verified 3.62143861266519 0.00014648466389973 yes 48 0.00021790209628516 25 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT Late endosomal protein involved in late endosome to vacuole trafficking; functional homolog of human obesity receptor gene-related protein (OB-RGRP) late endosome to vacuole transport via multivesicular body sorting pathway molecular_function Vps55/Vps68 complex|late endosome|integral to membrane
YLR065C YLR065C ENV10 hom Verified 3.6149901919255 0.000150179496389145 yes 49 0.00137221021627091 77 NA FF|FT VACUOLAR PROTEIN PROCESSING Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing; YLR065C is not an essential gene vacuolar protein processing molecular_function integral to membrane
YGL209W YGL209W MIG2 hom Verified 3.57152186357719 0.000177456456818854 yes 50 8.73320868304883e-05 11 NA FT TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS NUCLEUS|MITOCHONDRION Zinc finger transcriptional repressor; cooperates with Mig1p in glucose-induced repression of many genes; under low glucose conditions Mig2p relocalizes to mitochondrion, where it interacts with Ups1p and antagonizes mitochondrial fission factor, Dnm1p, indicative of a role in mitochondrial fusion or regulating morphology; regulates filamentous growth along with Mig2p in response to glucose depletion; MIG2 has a paralog, MIG3, that arose from the whole genome duplication negative regulation of transcription from RNA polymerase II promoter by glucose|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding mitochondrion|nucleus
YCL008C YCL008C STP22 hom Verified 3.56878018602835 0.000179323584464891 yes 51 0.000798356513574817 92 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT PLASMA MEMBRANE Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype protein targeting to membrane|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|late endosome to vacuole transport|protein targeting to vacuole ubiquitin binding endosome|ESCRT I complex|internal side of plasma membrane
YPL234C YPL234C VMA11 hom Verified 3.53745104276622 0.000202004538815557 yes 52 0.000283815632919581 5 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Vacuolar ATPase V0 domain subunit c', involved in proton transport activity; hydrophobic integral membrane protein (proteolipid) containing four transmembrane segments; N and C termini are in the vacuolar lumen vacuolar acidification proton-transporting ATPase activity, rotational mechanism vacuolar proton-transporting V-type ATPase, V0 domain|integral to membrane|fungal-type vacuole
YNL093W YNL093W YPT53 hom Verified 3.52293258560415 0.000213399953317273 yes 53 0.00043559271814179 45 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|VACUOLAR TRANSPORT PLASMA MEMBRANE Rab family GTPase; similar to Ypt51p and Ypt52p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; YPT53 has a paralog, VPS21, that arose from the whole genome duplication endocytosis|protein targeting to vacuole GTPase activity late endosome
YNL051W YNL051W COG5 hom Verified 3.50385532372159 0.000229287210725333 yes 54 0.00833176895812145 86 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments intra-Golgi vesicle-mediated transport|CVT pathway molecular_function Golgi transport complex
YBR008C YBR008C FLR1 hom Verified 3.45447587209321 0.000275681774483133 yes 55 0.000127326998292388 34 NA FT PLASMA MEMBRANE Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; expression induced in cells treated with the mycotoxin patulin; relocalizes from nucleus to plasma membrane upon DNA replication stress drug transmembrane transport|transmembrane transport fluconazole transporter activity|drug transmembrane transporter activity integral to membrane|plasma membrane
YDR075W YDR075W PPH3 hom Verified 3.43891292260042 0.000292027533253664 yes 56 7.9539259616145e-05 27 NA FT CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Catalytic subunit of protein phosphatase PP4 complex; active complex is composed of Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; involved in activation of Gln3p to alleviate nitrogen catabolite repression; Pph3p and Psy2p localize to foci on meiotic chromosomes Unknown|signal transduction involved in meiotic recombination checkpoint|double-strand break repair via homologous recombination|protein dephosphorylation|positive regulation of nitrogen compound metabolic process protein serine/threonine phosphatase activity condensed nuclear chromosome|nucleus|cytoplasm
YDR451C YDR451C YHP1 hom Verified 3.43091807623054 0.000300771119149391 yes 57 0.00206857446187424 54 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE NUCLEUS|CHROMOSOME Homeobox transcriptional repressor; binds Mcm1p and early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval; YHP1 has a paralog, YOX1, that arose from the whole genome duplication negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription involved in G1 phase of mitotic cell cycle RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription nuclear chromatin|nucleus
YCR026C YCR026C NPP1 hom Verified 3.36662553673841 0.000380469694443088 yes 58 0.000738433481793163 61 NA FT NUCLEOTIDE METABOLISM|RESPONSE TO NUTRIENT LEVELS Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; NPP1 has a paralog, NPP2, that arose from the whole genome duplication cellular response to phosphate starvation|phosphate-containing compound metabolic process|nucleoside triphosphate metabolic process nucleotide diphosphatase activity|nucleoside-triphosphate diphosphatase activity|nucleoside-triphosphatase activity|phosphodiesterase I activity cellular_component
YNL084C YNL084C END3 hom Verified 3.36570229687828 0.000381745300171849 yes 59 0.00201713361985817 95 NA FF|FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p bipolar cellular bud site selection|ascospore wall assembly|endocytosis|actin filament organization|cytokinesis|actin cortical patch assembly protein binding, bridging mating projection tip|actin cortical patch
YKR027W YKR027W BCH2 hom Verified 3.3622608466143 0.000386535292453619 yes 60 0.000392050907325174 26 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM MITOCHONDRION|GOLGI APPARATUS Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; BCH2 has a paralog, CHS6, that arose from the whole genome duplication Golgi to plasma membrane transport|fungal-type cell wall chitin biosynthetic process molecular_function trans-Golgi network transport vesicle|mitochondrion|clathrin-coated vesicle|exomer complex
YER087C-B YER087C-B SBH1 hom Verified 3.34524955085639 0.000411042834705531 yes 61 0.00201220252803957 45 NA FT PROTEIN LOCALIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Beta subunit of the Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p); involved in protein translocation into the endoplasmic reticulum; interacts with the exocyst complex and also with Rtn1p; homologous to Sbh2p posttranslational protein targeting to membrane, translocation|SRP-dependent cotranslational protein targeting to membrane, translocation ARF guanyl-nucleotide exchange factor activity|P-P-bond-hydrolysis-driven protein transmembrane transporter activity Sec61 translocon complex
YOR005C YOR005C DNL4 hom Verified 3.3265929647125 0.000439573444479103 yes 62 0.000202671378544727 19 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION NUCLEUS|CHROMOSOME DNA ligase required for nonhomologous end-joining (NHEJ), forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth double-strand break repair via nonhomologous end joining|replicative cell aging DNA ligase (ATP) activity DNA ligase IV complex|nuclear chromatin
YMR119W YMR119W ASI1 hom Verified 3.32403294130526 0.000443628574601511 yes 63 0.00143456059652158 45 NA FT PROTEOLYSIS ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Putative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals; ASI1 has a paralog, ASI3, that arose from the whole genome duplication ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity integral to membrane|nuclear inner membrane|endoplasmic reticulum membrane
YER083C YER083C GET2 hom Verified 3.26853882127309 0.000540521731101071 yes 64 0.00840356580993493 140 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for meiotic nuclear division retrograde vesicle-mediated transport, Golgi to ER|protein insertion into ER membrane protein anchor integral to membrane|endoplasmic reticulum|GET complex
YDR350C YDR350C ATP22 hom Verified 3.23621108401063 0.000605638880414588 yes 65 0.000784329528811162 15 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Specific translational activator for the mitochondrial ATP6 mRNA, encoding a subunit of F1F0 ATP synthase; localized to the mitochondrial inner membrane proton-transporting ATP synthase complex biogenesis|positive regulation of mitochondrial translation translation regulator activity mitochondrial inner membrane
YKR072C YKR072C SIS2 hom Verified 3.19912697594934 0.000689222214031533 yes 66 0.00467760574434013 110 NA FF|FT CELL CYCLE|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM NUCLEUS Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis regulation of mitotic cell cycle|response to salt stress|coenzyme A biosynthetic process phosphopantothenoylcysteine decarboxylase activity|protein phosphatase inhibitor activity phosphopantothenoylcysteine decarboxylase complex|nucleus|cytoplasm
YLR110C YLR110C CCW12 hom Verified 3.19834894494571 0.000691084613705809 yes 67 0.00656487203084843 158 NA FF|FT CELL WALL ORG/BIOGENESIS SITE OF POLARIZED GROWTH Cell wall mannoprotein; plays a role in maintenance of newly synthesized areas of cell wall; localizes to periphery of small buds, septum region of larger buds, and shmoo tip; CCW12 has a paralog, YDR134C, that arose from the whole genome duplication conjugation with cellular fusion|agglutination involved in conjugation with cellular fusion|fungal-type cell wall organization molecular_function fungal-type cell wall|mating projection tip|cellular bud tip
YBR200W YBR200W BEM1 hom Verified 3.19216498926792 0.000706053233878837 yes 68 0.000322550050630736 7 NA FT SITE OF POLARIZED GROWTH|CYTOSKELETON Protein containing SH3-domains, involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p establishment of cell polarity|cell morphogenesis involved in conjugation with cellular fusion protein complex scaffold|phosphatidylinositol-3-phosphate binding incipient cellular bud site|mating projection tip|cellular bud neck|cellular bud tip
YNL133C YNL133C FYV6 hom Verified 3.18474959032136 0.000724396574128824 yes 69 0.00334754391282038 53 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Protein of unknown function, required for survival upon exposure to K1 killer toxin; proposed to regulate double-strand break repair via non-homologous end-joining double-strand break repair via nonhomologous end joining molecular_function nucleus
YFR032C-A YFR032C-A RPL29 hom Verified 3.17601645347071 0.000746562411614843 yes 70 0.000783767295489314 41 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L29; not essential for translation, but required for proper joining of large and small ribosomal subunits and for normal translation rate; homologous to mammalian ribosomal protein L29, no bacterial homolog cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit|cytoplasm
YPL100W YPL100W ATG21 hom Verified 3.15803949725877 0.000794170180682083 yes 71 0.000941165936353618 34 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Phosphoinositide binding protein required for vesicle formation in the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein piecemeal microautophagy of nucleus|vesicle organization|mitochondrion degradation|macroautophagy|protein localization to pre-autophagosomal structure|CVT pathway|protein lipidation phosphatidylinositol binding endosome|cytosol|fungal-type vacuole membrane
YNL334C YNL334C SNO2 hom Verified 3.15574745467462 0.000800437030940089 yes 72 0.000930065837384379 36 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Protein of unknown function, nearly identical to Sno3p; expression is induced before the diauxic shift and also in the absence of thiamin pyridoxine metabolic process|thiamine biosynthetic process molecular_function cellular_component
YKR088C YKR088C TVP38 hom Verified 3.1509576047344 0.00081368054980221 yes 73 0.000890664283667969 40 NA FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|CYTOSKELETON ORGANIZATION ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; required for asymmetric localization of Kar9p during mitosis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern vesicle-mediated transport|mitotic spindle elongation molecular_function integral to membrane|integral to Golgi membrane|cytoplasm
YNL045W YNL045W LAP2 hom Verified 3.14986223480229 0.000816737347929269 yes 74 0.000419919464996142 19 NA FT KETONE METABOLISM|LIPID METABOLISM|PROTEOLYSIS NUCLEUS Leucyl aminopeptidase yscIV (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus cellular lipid metabolic process|protein catabolic process aminopeptidase activity|leukotriene-A4 hydrolase activity|epoxide hydrolase activity nucleus|cytoplasm
YIL052C YIL052C RPL34B hom Verified 3.14003171541579 0.000844647725521423 yes 75 0.00404562998495487 112 NA FF|FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YDR320C YDR320C SWA2 hom Verified 3.12650963810436 0.000884473530146277 yes 76 0.00787343381776816 110 NA FF|FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|NUCLEOTIDE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles positive regulation of ATPase activity|endoplasmic reticulum inheritance|clathrin coat disassembly ubiquitin binding|clathrin binding endoplasmic reticulum membrane
YBR001C YBR001C NTH2 hom Verified 3.10809033300588 0.000941502516960991 yes 77 0.00130675516288965 97 NA FF|FT CARBOHYDRATE METABOLISM MITOCHONDRION Putative neutral trehalase, required for thermotolerance; may mediate resistance to other cellular stresses; NTH2 has a paralog, NTH1, that arose from the whole genome duplication trehalose catabolic process alpha,alpha-trehalase activity mitochondrion|cytoplasm
YLR450W YLR450W HMG2 hom Verified 3.0704159899045 0.00106880406649211 no 78 0.000138519903710211 21 NA FT LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM HMG-CoA reductase; converts HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; one of two isozymes; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks; forms foci at the nuclear periphery upon DNA replication stress ergosterol biosynthetic process hydroxymethylglutaryl-CoA reductase (NADPH) activity nuclear envelope|integral to membrane|endoplasmic reticulum membrane
YMR310C_p YMR310C YMR310C hom Uncharacterized 3.06214385100144 0.00109878907485965 no 79 0.00181479822482304 44 NA FT NUCLEUS Putative S-adenosylmethionine-dependent methyltransferase; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR310C is not an essential gene biological_process S-adenosylmethionine-dependent methyltransferase activity nucleus
YGR167W YGR167W CLC1 hom Verified 3.05400536013326 0.0011290402313271 no 80 0.00475846583544263 129 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|GOLGI APPARATUS|PLASMA MEMBRANE Clathrin light chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function; two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component; YGR167W endocytosis|vesicle-mediated transport structural molecule activity clathrin vesicle coat
YIL137C YIL137C TMA108 hom Verified 3.02505995778604 0.00124291921247585 no 81 0.000991464019462535 37 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|PROTEOLYSIS Protein that associates with ribosomes and is involved in ribosome biogenesis; putative metalloprotease ribosome biogenesis molecular_function ribosome|cytoplasm
YJR032W YJR032W CPR7 hom Verified 2.99705099871736 0.00136302552315671 no 82 0.00221064805132436 59 NA Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity protein refolding|response to stress unfolded protein binding|peptidyl-prolyl cis-trans isomerase activity cytosol
YNL271C YNL271C BNI1 hom Verified 2.99161625418702 0.0013875242740206 no 83 0.00722978205868072 101 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1 barbed-end actin filament capping|actin nucleation|actin filament bundle assembly involved in cytokinetic actomyosin contractile ring assembly|establishment of mitotic spindle orientation|formin-nucleated actin cable assembly profilin binding incipient cellular bud site|actin filament|polarisome|plasma membrane|cellular bud neck|mating projection tip|cellular bud tip
YIL153W YIL153W RRD1 hom Verified 2.95344337582774 0.00157125127168502 no 84 0.00343811785874079 96 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RESPONSE TO DNA DAMAGE|CYTOSKELETON ORGANIZATION NUCLEUS|CHROMOSOME Peptidyl-prolyl cis/trans-isomerase; activator of the phosphotyrosyl phosphatase activity of PP2A; involved in G1 phase progression, microtubule dynamics, bud morphogenesis and DNA repair; required for rapid reduction of Sgs1p levels in response to rapamycin; subunit of the Tap42p-Sit4p-Rrd1p complex; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress DNA repair|mitotic spindle organization in nucleus|G1/S transition of mitotic cell cycle|response to osmotic stress|regulation of transcription from RNA polymerase II promoter in response to stress peptidyl-prolyl cis-trans isomerase activity|protein phosphatase type 2A regulator activity nuclear chromatin|nucleus|cytoplasm
YJL212C YJL212C OPT1 hom Verified 2.92957841805894 0.00169711078796761 no 85 0.00143848048515334 41 NA FT PROTEIN LOCALIZATION PLASMA MEMBRANE Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family oligopeptide transport|sulfur compound metabolic process oligopeptide transporter activity|proton-dependent oligopeptide secondary active transmembrane transporter activity integral to membrane|integral to plasma membrane
YMR292W YMR292W GOT1 hom Verified 2.90088157606019 0.00186057239321365 no 86 0.000926632163117286 39 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Homodimeric protein that is packaged into COPII vesicles and cycles between the ER and Golgi; involved in secretory transport but not directly required for aspects of transport assayed in vitro; may influence membrane composition ER to Golgi vesicle-mediated transport|Golgi to endosome transport molecular_function integral to membrane|endoplasmic reticulum|Golgi apparatus|ER to Golgi transport vesicle|Golgi membrane
YMR099C YMR099C YMR099C hom Verified 2.89403687917134 0.00190161744837123 no 87 0.00329397477220654 84 NA FT CARBOHYDRATE METABOLISM NUCLEUS Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS cellular carbohydrate metabolic process glucose-6-phosphate 1-epimerase activity nucleus|cytoplasm
YBR231C YBR231C SWC5 hom Verified 2.88029593222912 0.00198651028643141 no 88 0.00977486576592344 159 NA FF|FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Component of the SWR1 complex; complex exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; protein abundance increases in response to DNA replication stress chromatin remodeling|histone exchange molecular_function Swr1 complex|nucleus
YGR200C YGR200C ELP2 hom Verified 2.87954822795357 0.00199122691184554 no 89 0.00430825983203923 52 NA FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin regulation of transcription from RNA polymerase II promoter|protein urmylation|tRNA wobble uridine modification molecular_function Elongator holoenzyme complex|nucleus|cytoplasm
YBL047C YBL047C EDE1 hom Verified 2.87763031886248 0.00200337188482469 no 90 0.000526866845664627 55 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING SITE OF POLARIZED GROWTH|CYTOSKELETON Endocytic protein; involved in a network of interactions with other endocytic proteins, binds membranes in a ubiquitin-dependent manner, may also bind ubiquitinated membrane-associated proteins; interacts with Cmk2 and functions upstream of CMK2 in regulating non-apoptotic cell death endoplasmic reticulum unfolded protein response|endocytosis ubiquitin binding cellular bud neck|mating projection tip|actin cortical patch|cellular bud tip
YPR199C YPR199C ARR1 hom Verified 2.87550732919498 0.00201689390293529 no 91 0.00111299109800575 42 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Transcriptional activator of the basic leucine zipper (bZIP) family, required for transcription of genes involved in resistance to arsenic compounds positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus|cytoplasm
YOL132W YOL132W GAS4 hom Verified 2.81795212135632 0.00241655081180094 no 92 0.00156504656088971 33 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM PLASMA MEMBRANE 1,3-beta-glucanosyltransferase, involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall ascospore wall assembly 1,3-beta-glucanosyltransferase activity fungal-type cell wall|integral to membrane
YEL062W YEL062W NPR2 hom Verified 2.80949710076879 0.00248094830280962 no 93 0.00419956367003241 79 NA FT SIGNALING|RESPONSE TO NUTRIENT LEVELS Subunit of SEA (Seh1-associated), Npr2/3, and Iml1p complexes; Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation; SEA complex is a coatomer-related complex that associates dynamically with the vacuole; Iml1p complex (Iml1p-Npr2p-Npr3p) is required for non-nitrogen-starvation (NNS)-induced autophagy; Iml1p interacts primarily with phosphorylated Npr2p; homolog of human NPRL2; target of Grr1p; required for growth on urea and proline proline transport|urea transport|regulation of TOR signaling cascade|cellular response to amino acid starvation|response to drug|cellular response to nitrogen starvation molecular_function Seh1-associated complex|extrinsic to fungal-type vacuolar membrane
YPL164C YPL164C MLH3 hom Verified 2.80178115604158 0.00254106678173875 no 94 0.0023489914655028 42 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Protein involved in DNA mismatch repair and crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian microsatellite instability mismatch repair|reciprocal meiotic recombination molecular_function nucleus|MutLbeta complex
YPL274W YPL274W SAM3 hom Verified 2.79696132623521 0.00257928538172788 no 95 0.00421780854254146 37 NA FT ENDOPLASMIC RETICULUM|PLASMA MEMBRANE High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p spermidine transport|putrescine transport|S-adenosylmethionine transport S-adenosylmethionine transmembrane transporter activity|spermidine transmembrane transporter activity|putrescine transmembrane transporter activity integral to membrane|plasma membrane
YPL254W YPL254W HFI1 hom Verified 2.79215781665036 0.0026178906406072 no 96 0.00436993163510144 73 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS HISTONE ACETYLTRANSFERASE Adaptor protein required for structural integrity of the SAGA complex, a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions histone acetylation|chromatin modification|transcription from RNA polymerase II promoter transcription coactivator activity|transcription cofactor activity SLIK (SAGA-like) complex|Ada2/Gcn5/Ada3 transcription activator complex|SAGA complex
YCR100C_p YCR100C YCR100C hom Uncharacterized 2.78505834308049 0.00267590462556124 no 97 0.00484185018839683 55 NA Putative protein of unknown function biological_process molecular_function integral to membrane
YGL226W YGL226W MTC3 hom Verified 2.78366568088104 0.00268742017850313 no 98 0.00155009002224474 62 NA FT MITOCHONDRION Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; mtc3 is synthetically sick with cdc13-1 biological_process molecular_function mitochondrion
YGR242W_d YGR242W YGR242W hom Dubious 2.77404837045858 0.00276817229001469 no 99 0.00290512589877484 59 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C Unknown Unknown Unknown
YBL046W YBL046W PSY4 hom Verified 2.76485561983596 0.00284739977345949 no 100 0.00235326531653883 98 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS Regulatory subunit of protein phosphatase PP4; presence of Psy4p in the PP4 complex (along with catalytic subunit Pph3p and Psy2p) is required for dephosphorylation of the histone variant H2AX, but not for dephosphorylation of Rad53p, during recovery from the DNA damage checkpoint; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; required for cisplatin resistance; homolog of mammalian R2 Unknown|protein dephosphorylation protein phosphatase regulator activity nucleus|cytoplasm
YOL004W YOL004W SIN3 hom Verified 2.76382849752931 0.00285637783993026 no 101 0.00276030246390114 84 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CELL DIVISION|GENE SILENCING NUCLEUS|CHROMOSOME Component of the Sin3p-Rpd3p histone deacetylase complex, involved in transcriptional repression and activation of diverse processes, including mating-type switching and meiosis; involved in the maintenance of chromosomal integrity positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of chromatin silencing at rDNA|histone deacetylation|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of transcription from RNA polymerase I promoter|negative regulation of transcription during meiosis|regulation of DNA-dependent DNA replication initiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of chromatin silencing at telomere|double-strand break repair via nonhomologous end joining|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription involved in G2/M-phase of mitotic cell cycle transcription coactivator activity|transcription corepressor activity Sin3-type complex|Rpd3S complex|Rpd3L-Expanded complex|Rpd3L complex
YER130C_p YER130C YER130C hom Uncharacterized 2.74284686534652 0.00304545414328352 no 102 0.0111922882762002 107 NA FT NUCLEUS Protein of unknown function; transcription is regulated by Haa1p, Sok2p and Zap1p transcriptional activators; computational analysis suggests a role as a transcription factor; C. albicans homolog (MNL1) plays a role in adaptation to stress biological_process sequence-specific DNA binding cellular_component
YCR044C YCR044C PER1 hom Verified 2.73912597499027 0.00308013820302349 no 103 0.0276368135079093 167 NA FF|FT LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein of the endoplasmic reticulum, required for GPI-phospholipase A2 activity that remodels the GPI anchor as a prerequisite for association of GPI-anchored proteins with lipid rafts; functionally complemented by human ortholog PERLD1 GPI anchor biosynthetic process|cellular manganese ion homeostasis molecular_function fungal-type vacuole membrane|integral to membrane|endoplasmic reticulum
YBR200W-A_p YBR200W-A YBR200W-A hom Uncharacterized 2.73890339543956 0.00308222419670233 no 104 0.00590640774713815 77 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YML099C YML099C ARG81 hom Verified 2.73782307973388 0.00309236689198489 no 105 0.00379494460205447 57 NA FT VESICLE-MEDIATED TRANSPORT|TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type, involved in the regulation of arginine-responsive genes; acts with Arg80p and Arg82p arginine metabolic process|negative regulation of calcium ion-dependent exocytosis transcription cofactor activity nucleus
YKR035W-A YKR035W-A DID2 hom Verified 2.73054010269247 0.00316153198392329 no 106 0.00328910757562077 57 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM Class E protein of the vacuolar protein-sorting (Vps) pathway; binds Vps4p and directs it to dissociate ESCRT-III complexes; forms a functional and physical complex with Ist1p; human ortholog may be altered in breast tumors late endosome to vacuole transport via multivesicular body sorting pathway|late endosome to vacuole transport|protein targeting to vacuole molecular_function late endosome|cytoplasm
YKL222C YKL222C YKL222C hom Verified 2.72468742717138 0.00321811938827036 no 107 0.00361025886890025 58 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS|CYTOSKELETON Protein of unknown function that may interact with ribosomes, based on co-purification experiments; similar to transcriptional regulators from the zinc cluster (binuclear cluster) family; null mutant is sensitive to caffeine biological_process sequence-specific DNA binding ribosome|nucleus|mitotic spindle
YKR049C YKR049C FMP46 hom Verified 2.72131357262006 0.00325115247877095 no 108 0.0024129023995872 51 NA FT OXIDATION-REDUCTION PROCESS MITOCHONDRION Putative redox protein containing a thioredoxin fold; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process oxidoreductase activity mitochondrion
YLR039C YLR039C RIC1 hom Verified 2.72101192672233 0.00325412066758937 no 109 0.030203921230415 140 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes intracellular protein transport|retrograde transport, endosome to Golgi guanyl-nucleotide exchange factor activity nucleus|Ric1p-Rgp1p complex|Golgi membrane|guanyl-nucleotide exchange factor complex
YNR023W YNR023W SNF12 hom Verified 2.71820157485656 0.003281891828526 no 110 0.0222501882134008 135 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS NUCLEUS RSC COMPLEX 73 kDa subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; homolog of Rsc6p subunit of the RSC chromatin remodeling complex; relocates to the cytosol under hypoxic conditions; deletion mutants are temperature-sensitive positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation|positive regulation of transcription from RNA polymerase II promoter molecular_function SWI/SNF complex
YOL076W YOL076W MDM20 hom Verified 2.67390947000303 0.00374863437016415 no 111 0.00840091435445838 164 NA FF|FT MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly mitochondrion inheritance|N-terminal peptidyl-methionine acetylation|cytoskeleton organization peptide alpha-N-acetyltransferase activity NatB complex
YNL077W YNL077W APJ1 hom Verified 2.66735062572936 0.00382259328401421 no 112 0.0102830304389935 89 NA FT NUCLEUS|MITOCHONDRION Chaperone with a role in SUMO-mediated protein degradation; member of the DnaJ-like family; conserved across eukaryotes; overexpression interferes with propagation of the [Psi+] prion; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress biological_process unfolded protein binding mitochondrion|nucleus|cytoplasm
YDL100C YDL100C GET3 hom Verified 2.66459112250905 0.00385409900045343 no 113 0.0225058737724076 180 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|NUCLEOTIDE METABOLISM ENDOPLASMIC RETICULUM|GOLGI APPARATUS Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity; protein abundance increases in response to DNA replication stress retrograde vesicle-mediated transport, Golgi to ER|pheromone-dependent signal transduction involved in conjugation with cellular fusion|response to heat|protein insertion into ER membrane|response to metal ion|posttranslational protein targeting to membrane ATPase activity|guanyl-nucleotide exchange factor activity endoplasmic reticulum|GET complex
YOR309C_d YOR309C YOR309C hom Dubious 2.66168772573755 0.00388749861774363 no 114 0.00793896837190461 92 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58 Unknown Unknown Unknown
YKL097C_d YKL097C YKL097C hom Dubious 2.65339273255901 0.00398435470043253 no 115 0.00200021563126391 29 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species Unknown Unknown Unknown
YNL115C_p YNL115C YNL115C hom Uncharacterized 2.65006414431624 0.0040238245049761 no 116 0.00250631808108703 58 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene biological_process molecular_function integral to membrane|fungal-type vacuole
YDL226C YDL226C GCS1 hom Verified 2.64770866614938 0.00405196648163276 no 117 0.0133996205041809 289 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|SIGNALING|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION MITOCHONDRION|GOLGI APPARATUS|CYTOSKELETON ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p retrograde vesicle-mediated transport, Golgi to ER|Golgi to plasma membrane protein transport|actin filament reorganization involved in cell cycle|ER to Golgi vesicle-mediated transport actin binding|ARF GTPase activator activity|GTPase activator activity endosome|trans-Golgi network|endoplasmic reticulum-Golgi intermediate compartment|cytoskeleton
YDR372C YDR372C VPS74 hom Verified 2.64409327001984 0.00409550410531588 no 118 0.00880103842284671 127 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33 retrograde vesicle-mediated transport, Golgi to ER|endoplasmic reticulum unfolded protein response|protein localization to Golgi apparatus enzyme binding|phosphatidylinositol-4-phosphate binding cytosol|Golgi apparatus|nucleus|extrinsic to membrane|cytoplasm
YPR101W YPR101W SNT309 hom Verified 2.64036351929465 0.00414085709820274 no 119 0.00724316271039638 98 NA FT RNA PROCESSING NUCLEUS Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; interacts physically and genetically with Prp19p mRNA splicing, via spliceosome first spliceosomal transesterification activity Prp19 complex|U2-type catalytic step 1 spliceosome
YAR031W YAR031W PRM9 hom Verified 2.639898337088 0.00414654502050648 no 120 0.00520282508999985 46 NA FT VESICLE-MEDIATED TRANSPORT ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Pheromone-regulated protein with 3 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; member of DUP240 gene family vesicle organization molecular_function integral to membrane|endoplasmic reticulum|plasma membrane
YDR173C YDR173C ARG82 hom Verified 2.63566395090545 0.00419864241268837 no 121 0.00565834661315777 120 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM NUCLEUS Inositol polyphosphate multikinase (IPMK), sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes protein stabilization|negative regulation of transcription from RNA polymerase II promoter|phosphatidylinositol phosphorylation|regulation of arginine metabolic process|inositol phosphate biosynthetic process|positive regulation of transcription from RNA polymerase II promoter inositol-1,4,5-trisphosphate 3-kinase activity|inositol-1,4,5-trisphosphate 6-kinase activity|phosphatidylinositol 3-kinase activity|protein binding, bridging|inositol tetrakisphosphate 6-kinase activity|inositol tetrakisphosphate 3-kinase activity|inositol-1,3,4,5,6-pentakisphosphate kinase activity nucleus
YEL059C-A YEL059C-A SOM1 hom Verified 2.61764463199678 0.0044269479086169 no 122 0.00277500684752656 55 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs proteolysis|mitochondrial respiratory chain complex assembly endopeptidase activity mitochondrial inner membrane peptidase complex|mitochondrial inner membrane
YDR202C YDR202C RAV2 hom Verified 2.60854120093878 0.00454645323677024 no 123 0.0101640326176585 103 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS Subunit of RAVE (Rav1p, Rav2p, Skp1p), a complex that associates with the V1 domain of the vacuolar membrane (H+)-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme vacuolar acidification|regulation of protein complex assembly molecular_function RAVE complex
YKR087C YKR087C OMA1 hom Verified 2.5982405842679 0.0046851408452263 no 124 0.00533969389602231 97 NA FT PROTEOLYSIS MITOCHONDRION Metalloendopeptidase of the mitochondrial inner membrane; involved in turnover of membrane-embedded proteins; mediates degradation of Cox1p in coa2 mutant cells; member of a family of predicted membrane-bound metallopeptidases in prokaryotes and higher eukaryotes misfolded or incompletely synthesized protein catabolic process metalloendopeptidase activity mitochondrion|mitochondrial inner membrane
YNL325C YNL325C FIG4 hom Verified 2.58158022685575 0.00491745646795648 no 125 0.00727561326351238 87 NA FT LIPID METABOLISM Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase; required for efficient mating and response to osmotic shock; physically associates with and regulated by Vac14p; contains a SAC1-like domain phosphatidylinositol dephosphorylation phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity fungal-type vacuole membrane|PAS complex|extrinsic to membrane
YML005W YML005W TRM12 hom Verified 2.57926254307027 0.00495057520079027 no 126 0.00626023891412432 52 NA FT RNA PROCESSING S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; required for wybutosine formation in phenylalanine-accepting tRNA wybutosine biosynthetic process|tRNA methylation S-adenosylmethionine-dependent methyltransferase activity|transferase activity, transferring alkyl or aryl (other than methyl) groups cytoplasm
YHL008C_p YHL008C YHL008C hom Uncharacterized 2.57832294595427 0.00496405816325088 no 127 0.00591323472010206 67 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Putative protein of unknown function, may be involved in the uptake of chloride ions; does not appear to be involved in monocarboxylic acid transport; green fluorescent protein (GFP)-fusion protein localizes to the vacuole chloride transport|monocarboxylic acid transport monocarboxylic acid transmembrane transporter activity|transporter activity integral to membrane|fungal-type vacuole
YOR348C YOR348C PUT4 hom Verified 2.57277686707446 0.00504431135029614 no 128 0.00843241296398005 75 NA FT PLASMA MEMBRANE Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells neutral amino acid transport|proline transport|gamma-aminobutyric acid transport neutral amino acid transmembrane transporter activity|L-proline transmembrane transporter activity integral to membrane|plasma membrane
YPL144W YPL144W POC4 hom Verified 2.540873538022 0.00552879532849748 no 129 0.00482765055188961 80 NA FT PROTEIN COMPLEX ORG/BIOGENESIS Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions proteasome assembly|chaperone-mediated protein complex assembly molecular_function intracellular|cytoplasm
YPR173C YPR173C VPS4 hom Verified 2.52497654252554 0.0057853006137241 no 130 0.0144910047233924 145 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|LIPID METABOLISM|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT ENDOPLASMIC RETICULUM AAA-ATPase involved in multivesicular body (MVB) protein sorting, ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism late endosome to vacuole transport via multivesicular body sorting pathway|protein retention in Golgi apparatus|intralumenal vesicle formation|protein homooligomerization|sterol metabolic process|late endosome to vacuole transport ATPase activity|protein homodimerization activity|ATP binding endosome|endoplasmic reticulum|membrane|cytoplasm
YKR059W YKR059W TIF1 hom Verified 2.52404466796267 0.00580065932740745 no 131 0.0054545456153837 60 NA FT TRANSLATION RIBOSOME Translation initiation factor eIF4A; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; protein abundance increases in response to DNA replication stress; TIF1 has a paralog, TIF2, that arose from the whole genome duplication translational initiation ATP-dependent RNA helicase activity|translation initiation factor activity ribosome|eukaryotic translation initiation factor 4F complex
YGR092W YGR092W DBF2 hom Verified 2.52241392389716 0.00582762354447108 no 132 0.0219852791518126 192 NA FF|FT CELL CYCLE|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS SITE OF POLARIZED GROWTH|CYTOSKELETON Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; phosphorylates Chs2p to regulate primary septum formation and Hof1p to regulate cytokinesis nuclear division|protein phosphorylation|vacuolar acidification protein serine/threonine kinase activity|protein kinase activity spindle pole body|cellular bud neck
YHR204W YHR204W MNL1 hom Verified 2.52119248166647 0.00584789276892642 no 133 0.00469244475322402 99 NA FT PROTEOLYSIS ENDOPLASMIC RETICULUM Alpha-1,2-specific exomannosidase of the endoplasmic reticulum; in complex with Pdi1p, generates a Man7GlcNac2 oligosaccharide signal on glycoproteins destined for ubiquitin-proteasome degradation ER-associated protein catabolic process carbohydrate binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity endoplasmic reticulum lumen
YGL020C YGL020C GET1 hom Verified 2.51998934791232 0.00586791928909168 no 134 0.0156549280072628 164 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance retrograde vesicle-mediated transport, Golgi to ER|protein insertion into ER membrane protein anchor mitochondrion|integral to membrane|endoplasmic reticulum|GET complex
YER180C-A YER180C-A SLO1 hom Verified 2.5194172173397 0.00587746389780692 no 135 0.00948275005576863 121 NA FT PROTEIN LOCALIZATION Protein interacting with Arl3p, which is a GTPase of the Ras superfamily involved in vesicle-tethering at the Golgi; putative ortholog of human SCOCO intracellular protein transport small GTPase regulator activity cytoplasm
YMR312W YMR312W ELP6 hom Verified 2.5144220763733 0.00596138236266306 no 136 0.00867274782443178 90 NA FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity protein urmylation|regulation of transcription from RNA polymerase II promoter|tRNA wobble uridine modification ATPase activity|tRNA binding Elongator holoenzyme complex
YML071C YML071C COG8 hom Verified 2.51043213616434 0.00602917486019255 no 137 0.0951907241669833 476 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments intra-Golgi vesicle-mediated transport|CVT pathway molecular_function Golgi transport complex
YGL184C YGL184C STR3 hom Verified 2.49774471207096 0.00624930830964661 no 138 0.006306785029777 66 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Peroxisomal cystathionine beta-lyase, converts cystathionine into homocysteine; may be redox regulated by Gto1p methionine biosynthetic process|transsulfuration cystathionine beta-lyase activity peroxisome
YMR317W_p YMR317W YMR317W hom Uncharacterized 2.48625811830458 0.0064547147099949 no 139 0.00486482734664927 78 NA Putative protein of unknown function with some similarity to sialidase from Trypanosoma; YMR317W is not an essential gene biological_process molecular_function cellular_component
YER015W YER015W FAA2 hom Verified 2.48126827148037 0.00654579009014931 no 140 0.00658451303910916 89 NA FT KETONE METABOLISM|LIPID METABOLISM MITOCHONDRION Medium chain fatty acyl-CoA synthetase, activates imported fatty acids; accepts a wide range of fatty acid chain lengths with a preference for medium chains, C9:0-C13:0; localized to the peroxisome long-chain fatty acid metabolic process long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity|medium-chain fatty acid-CoA ligase activity mitochondrion|peroxisome
YER037W YER037W PHM8 hom Verified 2.47856971100873 0.00659551657467614 no 141 0.00792027302739084 81 NA FT RESPONSE TO NUTRIENT LEVELS NUCLEUS Lysophosphatidic acid (LPA) phosphatase involved in LPA hydrolysis in response to phosphate starvation; phosphatase activity is soluble and Mg2+ dependent; expression is induced by low phosphate levels and by inactivation of Pho85p cellular response to phosphate starvation lysophosphatidic acid phosphatase activity nucleus|cytoplasm
YPL206C YPL206C PGC1 hom Verified 2.47817745562884 0.00660277241566029 no 142 0.00644771978650224 93 NA FT LIPID METABOLISM|CARBOHYDRATE METABOLISM MITOCHONDRION Phosphatidyl Glycerol phospholipase C; regulates the phosphatidylglycerol (PG) content via a phospholipase C-type degradation mechanism; contains glycerophosphodiester phosphodiesterase motifs glycerophospholipid catabolic process|phosphatidylglycerol catabolic process phosphatidylglycerol phospholipase C activity mitochondrion|lipid particle
YBR194W YBR194W AIM4 hom Verified 2.47774362088538 0.00661080559979078 no 143 0.0156073808769413 107 NA Protein proposed to be associated with the nuclear pore complex; null mutant is viable, displays elevated frequency of mitochondrial genome loss and is sensitive to freeze-thaw stress biological_process molecular_function cytoplasm
YKL032C YKL032C IXR1 hom Verified 2.47598523956953 0.00664345356013278 no 144 0.011545372783283 112 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Protein that binds DNA containing intrastrand cross-links formed by cisplatin, contains two HMG (high mobility group box) domains, which confer the ability to bend cisplatin-modified DNA; mediates aerobic transcriptional repression of COX5b DNA repair|cellular response to hypoxia|negative regulation of transcription from RNA polymerase II promoter damaged DNA binding|sequence-specific DNA binding nuclear chromatin
YOL111C YOL111C MDY2 hom Verified 2.47400805006162 0.00668033431182709 no 145 0.0133276947762704 124 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION NUCLEUS Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Get4p; required for efficient mating; involved in shmoo formation and nuclear migration in the pre-zygote; associates with ribosomes protein insertion into ER membrane|cell morphogenesis involved in conjugation with cellular fusion|posttranslational protein targeting to membrane molecular_function ribosome|TRC complex|nucleus|cytoplasm
YOL002C YOL002C IZH2 hom Verified 2.46591379212549 0.00683321107198337 no 146 0.0058783657873263 96 NA FT KETONE METABOLISM|LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc response to zinc ion|cellular zinc ion homeostasis|response to toxin|cellular lipid metabolic process protein binding|metal ion binding integral to membrane|plasma membrane|membrane
YGL071W YGL071W AFT1 hom Verified 2.46181573940725 0.00691178323024347 no 147 0.0657943261746794 346 NA FF|FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|ION HOMEOSTASIS|ION HOMEOSTASIS|RESPONSE TO NUTRIENT LEVELS|CHROMOSOME SEGREGATION NUCLEUS Transcription factor involved in iron utilization and homeostasis; binds consensus site PyPuCACCCPu and activates transcription in response to changes in iron availability; in iron-replete conditions activity is negatively regulated by Grx3p, Grx4p, and Fra2p, which regulate Aft1p translocation from the nucleus to the cytoplasm; AFT1 has a paralog, AFT2, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress positive regulation of transcription from RNA polymerase II promoter in response to iron ion starvation|meiotic chromosome segregation|positive regulation of iron ion transport|establishment of mitotic sister chromatid cohesion|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding nucleus|cytoplasm
YBR164C YBR164C ARL1 hom Verified 2.45809911304244 0.00698373102256366 no 148 0.0356983371125544 253 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|VACUOLAR TRANSPORT GOLGI APPARATUS Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor Golgi to plasma membrane protein transport|vesicle-mediated transport|protein targeting to vacuole GTPase activity trans-Golgi network|cytosol|Golgi apparatus
YDR455C_d YDR455C YDR455C hom Dubious 2.44977772450517 0.0071472212938295 no 149 0.0194330312766454 251 NA FF Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W Unknown Unknown Unknown
YPL061W YPL061W ALD6 hom Verified 2.4336083368116 0.00747458053856277 no 150 0.0137757654467878 156 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM MITOCHONDRION Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress response to salt stress|NADPH regeneration|acetate biosynthetic process aldehyde dehydrogenase [NAD(P)+] activity cytosol|mitochondrion
YOR228C YOR228C YOR228C hom Verified 2.42692740600454 0.00761365120937484 no 151 0.00771063521073949 92 NA FT MITOCHONDRION Protein of unknown function, localized to the mitochondrial outer membrane biological_process molecular_function mitochondrial outer membrane|mitochondrion|integral to membrane
YJL088W YJL088W ARG3 hom Verified 2.41018223354359 0.00797227707892681 no 152 0.0106050807724356 161 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Ornithine carbamoyltransferase (carbamoylphosphate:L-ornithine carbamoyltransferase), catalyzes the sixth step in the biosynthesis of the arginine precursor ornithine arginine biosynthetic process|ornithine metabolic process ornithine carbamoyltransferase activity cytosol
YJR135W-A YJR135W-A TIM8 hom Verified 2.40573037058937 0.00807008607740449 no 153 0.00592986881609028 66 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial intermembrane space protein, forms a complex with Tim13p that delivers a subset of hydrophobic proteins to the TIM22 complex for inner membrane insertion; homolog of human TIMM8A, implicated in Mohr-Tranebjaerg syndrome protein import into mitochondrial inner membrane protein transporter activity mitochondrion|integral to membrane|mitochondrial intermembrane space protein transporter complex
YOR209C YOR209C NPT1 hom Verified 2.39936072202988 0.00821186324164459 no 154 0.0209908049800421 181 NA FF|FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|GENE SILENCING|RESPONSE TO OXIDATIVE STRESS NUCLEUS Nicotinate phosphoribosyltransferase, acts in the salvage pathway of NAD+ biosynthesis; required for silencing at rDNA and telomeres and has a role in silencing at mating-type loci; localized to the nucleus chromatin silencing at rDNA|replicative cell aging|nicotinate nucleotide salvage|chromatin silencing at telomere nicotinate phosphoribosyltransferase activity nucleus
YHL029C_p YHL029C OCA5 hom Uncharacterized 2.38880357939698 0.00845166838818533 no 155 0.0179597496453865 149 NA FT SIGNALING|NUCLEOTIDE METABOLISM Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts biological_process molecular_function cytoplasm
YPL162C_p YPL162C YPL162C hom Uncharacterized 2.38548272961253 0.00852836161477355 no 156 0.00824673085104663 100 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of vacuole with cell cycle-correlated morphology biological_process molecular_function fungal-type vacuole membrane|integral to membrane
YPL208W YPL208W RKM1 hom Verified 2.38475167128683 0.00854532679101577 no 157 0.00773950130709266 75 NA FT NUCLEUS SET-domain lysine-N-methyltransferase, catalyzes the formation of dimethyllysine residues on the large ribsomal subunit proteins L23a (Rpl23Ap and Rpl23Bp) and L18 (Rps18Ap and Rps18Bp) peptidyl-lysine dimethylation protein-lysine N-methyltransferase activity nucleus|cytoplasm
YER106W YER106W MAM1 hom Verified 2.37023308211563 0.00888843725461703 no 158 0.00660957848317829 116 NA FT CELL CYCLE|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME KINETOCHORE Monopolin, kinetochore associated protein involved in chromosome attachment to meiotic spindle meiotic chromosome segregation|meiotic sister chromatid cohesion involved in meiosis I molecular_function condensed nuclear chromosome kinetochore|monopolin complex
YPL127C YPL127C HHO1 hom Verified 2.36807624256065 0.008940425347747 no 159 0.0060200715613583 72 NA FT CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Histone H1, linker histone with roles in meiosis and sporulation; decreasing levels early in sporulation may promote meiosis, and increasing levels during sporulation facilitate compaction of spore chromatin; binds to promoters and within genes in mature spores; may be recruited by Ume6p to promoter regions, contributing to transcriptional repression outside of meiosis; suppresses DNA repair involving homologous recombination negative regulation of DNA recombination|negative regulation of chromatin silencing|regulation of transcription, DNA-dependent DNA binding nucleus|nuclear nucleosome
YMR170C YMR170C ALD2 hom Verified 2.36371402875386 0.00904638624972959 no 160 0.00736468879732177 87 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p cellular aldehyde metabolic process|beta-alanine biosynthetic process|polyamine catabolic process aldehyde dehydrogenase (NAD) activity cytoplasm
YPL054W YPL054W LEE1 hom Verified 2.3614978383006 0.00910063901667275 no 161 0.00530581674850668 56 NA Zinc-finger protein of unknown function biological_process molecular_function cellular_component
YIR019C YIR019C FLO11 hom Verified 2.35793766572286 0.00918838922569478 no 162 0.00530862176457409 89 NA FT SITE OF POLARIZED GROWTH|PLASMA MEMBRANE GPI-anchored cell surface glycoprotein (flocculin); required for pseudohyphal formation, invasive growth, flocculation, and biofilms; transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p); required for the formation of fibrous interconnections between cells in a colony of a wild S. cerevisiae strain cell-cell adhesion|biofilm formation|pseudohyphal growth|filamentous growth|flocculation|invasive growth in response to glucose limitation molecular_function extracellular region|plasma membrane|cellular bud neck
YGR252W YGR252W GCN5 hom Verified 2.3569948818707 0.00921175039150374 no 163 0.0440908961151477 247 NA FF|FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME HISTONE ACETYLTRANSFERASE Acetyltransferase, modifies N-terminal lysines on histones H2B and H3; acetylates Rsc4p, a subunit of the RSC chromatin-remodeling complex, altering replication stress tolerance; catalytic subunit of the ADA and SAGA histone acetyltransferase complexes; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; greater involvement in repression of RNAPII-dependent transcription than in activation histone acetylation|regulation of transcription by chromatin organization|chromatin modification|positive regulation of transcription elongation from RNA polymerase II promoter histone acetyl-lysine binding|transcription coactivator activity|histone acetyltransferase activity|H3 histone acetyltransferase activity SLIK (SAGA-like) complex|chromosome, centromeric region|Ada2/Gcn5/Ada3 transcription activator complex|SAGA complex
YNL041C YNL041C COG6 hom Verified 2.35456085349486 0.00927230350207126 no 164 0.112012529309474 470 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments intra-Golgi vesicle-mediated transport|CVT pathway molecular_function Golgi transport complex
YCR063W YCR063W BUD31 hom Verified 2.35188089023638 0.0093393775332743 no 165 0.00638529610252773 93 NA FT CELL CYCLE|RNA PROCESSING|CELL DIVISION NUCLEUS Component of the SF3b subcomplex of the U2 snRNP; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; facilitates passage through G1/S Start, but is not required for G2/M transition or exit from mitosis RNA splicing|mRNA splicing, via spliceosome|cellular bud site selection molecular_function U2 snRNP|nucleus
YHR140W_p YHR140W YHR140W hom Uncharacterized 2.34726752849425 0.00945583523029395 no 166 0.00542603350058109 55 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Putative integral membrane protein of unknown function biological_process molecular_function integral to membrane
YBR233W YBR233W PBP2 hom Verified 2.34321022537404 0.00955930356637282 no 167 0.0101058383212293 73 NA FT NUCLEUS RNA binding protein; has similarity to mammalian heterogeneous nuclear RNP K protein, involved in the regulation of telomere position effect and telomere length; relative distribution to the nucleus increases upon DNA replication stress telomere maintenance via telomere shortening mRNA binding cytoplasm
YMR258C YMR258C ROY1 hom Verified 2.32746260461551 0.00997032853775887 no 168 0.0108373274907295 119 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|NUCLEUS GTPase inhibitor with similarity to F-box proteins; inhibits Ypt52p GTPase activity by preventing Ypt52p from binding GTP; involved in regulating intracellular trafficking; physically interacts with Skp1p endocytosis|protein targeting to vacuole|negative regulation of GTPase activity GTPase inhibitor activity nucleus|cytoplasm
YHL005C_d YHL005C YHL005C hom Dubious 2.31934092352332 0.0101882790696017 no 169 0.00599120309352697 81 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YHL004W Unknown Unknown Unknown
YDR477W YDR477W SNF1 hom Verified 2.31538556204586 0.010295920475801 no 170 0.00889362100670517 10 NA FT KETONE METABOLISM|SIGNALING|TRANSLATION|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION AMP-activated serine/threonine protein kinase; found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; regulates filamentous growth in response to starvation negative regulation of translation|protein phosphorylation|replicative cell aging|signal transduction|biofilm formation|positive regulation of gluconeogenesis|pseudohyphal growth|cell adhesion|regulation of carbohydrate metabolic process|invasive growth in response to glucose limitation|cellular response to nitrogen starvation AMP-activated protein kinase activity|protein kinase activity mitochondrion|AMP-activated protein kinase complex|nucleus|nuclear envelope lumen|fungal-type vacuole|cytoplasm
YOR220W YOR220W RCN2 hom Verified 2.30209501249281 0.0106649073165988 no 171 0.00881306149960737 99 NA Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; phosphorylated in response to alpha factor; protein abundance increases in response to DNA replication stress biological_process molecular_function cytoplasm
YNL091W YNL091W NST1 hom Verified 2.30128299190974 0.0106878202411421 no 172 0.0100326601982309 119 NA Protein of unknown function, mediates sensitivity to salt stress; interacts physically with the splicing factor Msl1p and also displays genetic interaction with MSL1 response to salt stress molecular_function cytoplasm
YDR270W YDR270W CCC2 hom Verified 2.29242434828412 0.0109405841782401 no 173 0.0194729125376337 187 NA FF|FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism cellular iron ion homeostasis|copper ion export|transmembrane transport copper ion binding|cation-transporting ATPase activity integral to membrane|trans-Golgi network transport vesicle membrane
YGL127C YGL127C SOH1 hom Verified 2.29226260609068 0.0109452471167542 no 174 0.0158034804739699 146 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS RNA POL II, HOLOENZYME Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance; conserved with other metazoan MED31 subunits DNA repair|meiotic gene conversion|meiotic sister chromatid segregation|transcription from RNA polymerase II promoter molecular_function core mediator complex|nucleus
YBR240C YBR240C THI2 hom Verified 2.29016872600368 0.0110057688031546 no 175 0.0172220052875973 108 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Transcriptional activator of thiamine biosynthetic genes; interacts with regulatory factor Thi3p to control expression of thiamine biosynthetic genes with respect to thiamine availability; acts together with Pdc2p to respond to thiaminediphosphate demand, possibly as related to carbon source availability; zinc finger protein of the Zn(II)2Cys6 type thiamine biosynthetic process|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II activating transcription factor binding|RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription nucleus
YDL194W YDL194W SNF3 hom Verified 2.28917848736949 0.011034491998205 no 176 0.00883659326539722 96 NA FT CELL CYCLE|SIGNALING PLASMA MEMBRANE Plasma membrane low glucose sensor, regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; also senses fructose and mannose; SNF3 has a paralog, RGT2, that arose from the whole genome duplication mannose transport|glucose transport|signal transduction|negative regulation of meiosis|detection of glucose|fructose transport glucose transmembrane transporter activity|receptor activity|glucose binding integral to membrane|plasma membrane
YFL001W YFL001W DEG1 hom Verified 2.28698446661971 0.0110983648867482 no 177 0.0211866132154097 118 NA FT RNA PROCESSING NUCLEUS tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm; non-essential for viability tRNA pseudouridine synthesis pseudouridine synthase activity nucleus|cytoplasm
YNL231C YNL231C PDR16 hom Verified 2.28184417508716 0.0112492708362431 no 178 0.0174069388517963 199 NA FF|FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Phosphatidylinositol transfer protein (PITP); controlled by the multiple drug resistance regulator Pdr1p; localizes to lipid particles and microsomes; controls levels of various lipids, may regulate lipid synthesis; homologous to Pdr17p; protein abundance increases in response to DNA replication stress response to drug|sterol biosynthetic process|phospholipid biosynthetic process|phospholipid transport phosphatidylinositol transporter activity|phosphatidylcholine transporter activity cell periphery|lipid particle|plasma membrane|cytoplasm
YLR370C YLR370C ARC18 hom Verified 2.26631842293394 0.0117159471219285 no 179 0.0476556677736551 289 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION MITOCHONDRION|CYTOSKELETON Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches mitochondrion inheritance|actin filament organization|establishment of mitochondrion localization molecular_function mitochondrion|Arp2/3 protein complex
YML020W_p YML020W YML020W hom Uncharacterized 2.26599201289427 0.0117259361383419 no 180 0.0114453220075146 114 NA Putative protein of unknown function biological_process molecular_function cellular_component
YER149C YER149C PEA2 hom Verified 2.2606333168214 0.0118909864331415 no 181 0.0105584507075681 92 NA FT CELL CYCLE|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Coiled-coil polarisome protein required for polarized morphogenesis, cell fusion, and low affinity Ca2+ influx; forms polarisome complex with Bni1p, Bud6p, and Spa2p; localizes to sites of polarized growth bipolar cellular bud site selection|regulation of initiation of mating projection growth|regulation of termination of mating projection growth|actin filament organization|pseudohyphal growth|establishment of cell polarity|filamentous growth|Rho protein signal transduction cytoskeletal regulatory protein binding polarisome|actin cap|mating projection tip
YKL126W YKL126W YPK1 hom Verified 2.25889817449012 0.0119448597924163 no 182 0.132384620716712 622 NA FF|FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Serine/threonine protein kinase; phosphorylates and downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p (inhibitors of serine:palmitoyl-coenzyme A transferase) by phosphorylation in response to compromised sphingolipid synthesis; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK; YPK1 has a paralog, YPK2, that arose from the whole genome duplication eisosome assembly|protein autophosphorylation|negative regulation of phospholipid translocation|protein phosphorylation protein serine/threonine kinase activity cytosol|plasma membrane|cellular bud neck
YBR064W_d YBR064W YBR064W hom Dubious 2.25886121905693 0.0119460094974341 no 183 0.00797323930745598 102 NA Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YBR063C Unknown Unknown Unknown
YER092W YER092W IES5 hom Verified 2.25165564957163 0.0121720206960434 no 184 0.0178924593661827 177 NA FT NUCLEUS Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions biological_process molecular_function nucleus
YLR178C YLR178C TFS1 hom Verified 2.25040954678652 0.0122114797702563 no 185 0.00435961289905997 49 NA FT SIGNALING|PROTEOLYSIS Protein that interacts with and inhibits carboxypeptidase Y and Ira2p; phosphatidylethanolamine-binding protein (PEBP) family member; targets to vacuolar membranes during stationary phase; acetylated by NatB N-terminal acetyltransferase; protein abundance increases in response to DNA replication stress regulation of Ras protein signal transduction|regulation of proteolysis lipid binding|peptidase inhibitor activity|phospholipid binding fungal-type vacuole lumen|fungal-type vacuole membrane|cytoplasm
YKL218C YKL218C SRY1 hom Verified 2.24774860844468 0.0122961122754604 no 186 0.00813776072429661 79 NA FT KETONE METABOLISM|AMINO ACID METABOLISM 3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required in the presence of hydroxyaspartate; highly similar to mouse serine racemase (Srr) but has no serine racemase activity cellular modified amino acid catabolic process serine racemase activity|threo-3-hydroxyaspartate ammonia-lyase activity cellular_component
YOR264W YOR264W DSE3 hom Verified 2.24294090773002 0.0124503126738522 no 187 0.0104196245529357 98 NA FT CELL CYCLE SITE OF POLARIZED GROWTH Daughter cell-specific protein, may help establish daughter fate; relocalizes from bud neck to cytoplasm upon DNA replication stress biological_process molecular_function cellular bud neck
YGR144W YGR144W THI4 hom Verified 2.24259660961575 0.0124614195404292 no 188 0.0189667886161532 125 NA FT MITOCHONDRION ORGANIZATION NUCLEUS Thiazole synthase, abundant protein involved in the formation of the thiazole moiety of thiamine during thiamine biosynthesis; acts more as a co-substrate rather than an enzyme by providing the sulphur source for thiazole formation; undergoes a single turnover only; required for mitochondrial genome stability in response to DNA damaging agents thiamine biosynthetic process|mitochondrial genome maintenance|thiazole biosynthetic process ferrous iron binding cytosol
YPL161C YPL161C BEM4 hom Verified 2.24112515820187 0.0125089844962404 no 189 0.0502978739542917 281 NA FF|FT SIGNALING|CYTOSKELETON ORGANIZATION NUCLEUS Protein involved in establishment of cell polarity and bud emergence; interacts with the Rho1p small GTP-binding protein and with the Rho-type GTPase Cdc42p; involved in maintenance of proper telomere length establishment of cell polarity|Rho protein signal transduction|actin cytoskeleton organization molecular_function nucleus|cytoplasm
YLR454W_p YLR454W FMP27 hom Uncharacterized 2.24031036567716 0.0125353903849801 no 190 0.00969878711314181 125 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YOR024W_d YOR024W YOR024W hom Dubious 2.23746758512693 0.0126278978010491 no 191 0.0115362441552203 78 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YFR012W YFR012W DCV1 hom Verified 2.23549465055896 0.0126924462160471 no 192 0.00718897753050409 71 NA Protein of unknown function; deletion mutant shows strong genetic interaction with cdc28-as1 mutant in the presence of 1-NM-PP1; DCV1 has a paralog, YOL019W, that arose from the whole genome duplication biological_process molecular_function integral to membrane
YEL043W YEL043W YEL043W hom Verified 2.22047961135625 0.0131931140954389 no 193 0.0127867138760074 123 NA FT ENDOPLASMIC RETICULUM Predicted cytoskeleton protein involved in intracellular signalling based on quantitative analysis of protein-protein interaction maps; may interact with ribosomes, based on co-purification studies; contains fibronectin type III domain fold biological_process molecular_function ribosome|endoplasmic reticulum
YOL029C_p YOL029C YOL029C hom Uncharacterized 2.21618312833297 0.0133394814391974 no 194 0.0118470380577103 103 NA Putative protein of unknown function; identified as interacting with Hsc82p and Hsp82p in high-throughput two-hybrid screens biological_process molecular_function cellular_component
YNR059W YNR059W MNT4 hom Verified 2.2064129696499 0.0136775488763853 no 195 0.0126592269964279 119 NA FT CARBOHYDRATE METABOLISM Putative alpha-1,3-mannosyltransferase, not required for protein O-glycosylation protein O-linked glycosylation alpha-1,3-mannosyltransferase activity cellular_component
YDL020C YDL020C RPN4 hom Verified 2.19651934215721 0.0140273961429028 no 196 0.153311803160316 651 NA FF|FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|PROTEOLYSIS NUCLEUS Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance|regulation of DNA repair|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YMR067C YMR067C UBX4 hom Verified 2.19515369738412 0.0140762872103655 no 197 0.0230040550884252 158 NA FT PROTEOLYSIS NUCLEUS UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the Cdc48p-Nplp-Ufd1p AAA ATPase complex during its role in delivery of misfolded proteins to the proteasome; protein abundance increases in response to DNA replication stress ER-associated protein catabolic process|sporulation resulting in formation of a cellular spore protein complex binding nucleus|cytoplasm|extrinsic to membrane
YDR471W YDR471W RPL27B hom Verified 2.19335690282484 0.0141408374206452 no 198 0.0130309545365138 99 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L27B; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27B has a paralog, RPL27A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YNL098C YNL098C RAS2 hom Verified 2.19292224120884 0.0141564909864773 no 199 0.0305751970264426 167 NA FT PROTEIN LOCALIZATION|SIGNALING|NUCLEOTIDE METABOLISM|RESPONSE TO NUTRIENT LEVELS PLASMA MEMBRANE GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes pseudohyphal growth|ascospore formation|activation of adenylate cyclase activity|regulation of protein localization|replicative cell aging|positive regulation of transcription by galactose|Ras protein signal transduction GTP binding|GTPase activity plasma membrane
YOR342C YOR342C YOR342C hom Verified 2.17757842793865 0.014718718510989 no 200 0.0188062391532913 108 NA FT NUCLEUS Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; relocalizes from nucleus to cytoplasm upon DNA replication stress; YOR342C has a paralog, YAL037W, that arose from the whole genome duplication biological_process molecular_function nucleus|cytoplasm
YAR003W YAR003W SWD1 hom Verified 2.17503670832686 0.0148136828365285 no 201 0.0238194310802426 177 NA FT CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member with similarity to mammalian Rbbp7 histone H3-K4 methylation|telomere maintenance|regulation of transcription, DNA-dependent|chromatin silencing at telomere histone methyltransferase activity (H3-K4 specific) Set1C/COMPASS complex
YLR262C YLR262C YPT6 hom Verified 2.17493590511567 0.0148174599079887 no 202 0.0847536172417113 333 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING GOLGI APPARATUS|PLASMA MEMBRANE Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6 intracellular protein transport|retrograde transport, endosome to Golgi GTPase activity Golgi apparatus
YER175W-A_p YER175W-A YER175W-A hom Uncharacterized 2.17038572530337 0.0149888186383873 no 203 0.0126375356714986 115 NA Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YNL249C YNL249C MPA43 hom Verified 2.16834404057518 0.0150662599752485 no 204 0.0182555343441698 124 NA FT CARBOHYDRATE METABOLISM MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YEL005C YEL005C VAB2 hom Verified 2.15997220880501 0.0153874105259995 no 205 0.0145176194159832 130 NA Protein with a potential role in vacuolar function, as suggested by its ability to bind Vac8p; likely member of BLOC complex involved in endosomal cargo sorting; Vab2p-GFP-fusion localizes to cytoplasm in punctate patter biological_process molecular_function cytoplasm
YPL232W YPL232W SSO1 hom Verified 2.15978774977014 0.0153945522065162 no 206 0.0174744977014661 149 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION PLASMA MEMBRANE Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p ascospore formation|ascospore-type prospore assembly|vesicle fusion phosphatidic acid binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|SNAP receptor activity SNARE complex|fungal-type vacuole membrane|plasma membrane|prospore membrane
YHR010W YHR010W RPL27A hom Verified 2.15744995215821 0.0154853113481176 no 207 0.0116231766708264 141 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L27A; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27A has a paralog, RPL27B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YFL050C YFL050C ALR2 hom Verified 2.15398057154354 0.0156208477849409 no 208 0.0191321987520188 121 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Probable Mg(2+) transporter; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; plays a role in regulating Ty1 transposition magnesium ion transport|cation transport|transmembrane transport inorganic cation transmembrane transporter activity integral to membrane|plasma membrane
YBR229C YBR229C ROT2 hom Verified 2.15334355656051 0.0156458440036497 no 209 0.0152931118605638 147 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM ENDOPLASMIC RETICULUM|MITOCHONDRION Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations fungal-type cell wall biogenesis alpha-glucosidase activity glucosidase II complex|mitochondrion|endoplasmic reticulum|endoplasmic reticulum lumen
YOL107W_p YOL107W YOL107W hom Uncharacterized 2.15040472290226 0.015761607546087 no 210 0.0121975101549097 120 NA FT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and colocalizes in a punctate pattern with the early golgi/COPI vesicles; YOL107W is not an essential protein biological_process molecular_function COPI-coated vesicle|Golgi apparatus
YHR078W_p YHR078W YHR078W hom Uncharacterized 2.13823246848572 0.0162489402070874 no 211 0.0126008223280782 88 NA High osmolarity-regulated gene of unknown function biological_process molecular_function integral to membrane
YNL273W YNL273W TOF1 hom Verified 2.13465703959011 0.0163945172848746 no 212 0.012375409302207 103 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Subunit of a replication-pausing checkpoint complex (Tof1p-Mrc1p-Csm3p) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase DNA repair|DNA replication checkpoint|maintenance of DNA repeat elements|replication fork arrest|replication fork protection|DNA replication|mitotic sister chromatid cohesion molecular_function nuclear chromosome|replication fork protection complex|nuclear replication fork
YLR044C YLR044C PDC1 hom Verified 2.11694496803574 0.0171322593112097 no 213 0.0227174600199259 166 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde; subject to glucose-, ethanol-, and autoregulation; involved in amino acid catabolism L-phenylalanine catabolic process|pyruvate metabolic process|glucose catabolic process to ethanol|tryptophan catabolic process|aromatic amino acid family catabolic process to alcohol via Ehrlich pathway pyruvate decarboxylase activity cytosol|nucleus|cytoplasm
YBR015C YBR015C MNN2 hom Verified 2.11379191833595 0.0172665217661196 no 214 0.0351282874548006 267 NA FF|FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment protein glycosylation alpha-1,2-mannosyltransferase activity Golgi apparatus
YMR191W YMR191W SPG5 hom Verified 2.11276258140574 0.0173105469296665 no 215 0.0206054725121172 114 NA Protein required for proteasome assembly during quiescence; binds to base of the proteasome regulartory particle; required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources biological_process molecular_function cellular_component
YLR436C YLR436C ECM30 hom Verified 2.08400582202515 0.0185798188439352 no 216 0.0265015365045978 178 NA FT CELL WALL ORG/BIOGENESIS Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants have abormal relative levels of mannose and glucose and have Gap1p sorting and transport defects; (GFP)-fusion protein localizes to the cytoplasm fungal-type cell wall organization molecular_function cytoplasm
YNL012W YNL012W SPO1 hom Verified 2.07993775236769 0.0187656213631659 no 217 0.013246411857259 100 NA FT CELL CYCLE|LIPID METABOLISM|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Meiosis-specific prospore protein; required for meiotic spindle pole body duplication and separation; required to produce bending force necessary for proper prospore membrane assembly during sporulation; has similarity to phospholipase B meiosis|spore membrane bending pathway phospholipase activity endoplasmic reticulum|nucleus|prospore membrane
YPL194W YPL194W DDC1 hom Verified 2.07882301766846 0.0188168102248815 no 218 0.014043627277409 102 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME DNA damage checkpoint protein; part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate; forms nuclear foci upon DNA replication stress meiosis|mitotic cell cycle G1/S transition checkpoint|intra-S DNA damage checkpoint|recombinational repair|G2/M transition checkpoint|cell cycle checkpoint molecular_function condensed nuclear chromosome|checkpoint clamp complex
YML128C YML128C MSC1 hom Verified 2.07394687487006 0.0190421224935946 no 219 0.0241179075048521 171 NA FT CELL CYCLE ENDOPLASMIC RETICULUM|MITOCHONDRION Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated reciprocal meiotic recombination molecular_function mitochondrion|endoplasmic reticulum|plasma membrane
YJR033C YJR033C RAV1 hom Verified 2.07164956799234 0.0191490668591787 no 220 0.0345199853727259 263 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate early endosome to late endosome transport|vacuolar acidification|regulation of protein complex assembly molecular_function RAVE complex|cytoplasm|extrinsic to membrane
YCL005W-A YCL005W-A VMA9 hom Verified 2.06787722058289 0.0193257849757759 no 221 0.0322911167634628 220 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex; essential for vacuolar acidification; interacts with the V-ATPase assembly factor Vma21p in the ER; involved in V0 biogenesis cell wall mannoprotein biosynthetic process|vacuolar acidification|protein complex assembly|transmembrane transport ATPase activity, coupled to transmembrane movement of ions vacuolar proton-transporting V-type ATPase, V0 domain|fungal-type vacuole membrane
YJL161W_p YJL161W FMP33 hom Uncharacterized 2.06782997509458 0.019328006979528 no 222 0.0109947601887851 115 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YHR160C YHR160C PEX18 hom Verified 2.06723054059382 0.0193562178545962 no 223 0.0221886148643121 178 NA FT PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex21p protein import into peroxisome matrix protein binding cytosol|peroxisome
YER152C YER152C YER152C hom Verified 2.06669848697268 0.0193812869199659 no 224 0.0146344213931032 95 NA FT NUCLEUS Protein with 2-aminoadipate transaminase activity; shares amino acid similarity with the aminotransferases Aro8p and Aro9p; YER152C is not an essential gene biological_process 2-aminoadipate transaminase activity nucleus|cytoplasm
YHR125W_d YHR125W YHR125W hom Dubious 2.06348185463662 0.0195334350217492 no 225 0.0254703549769467 188 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YHL025W YHL025W SNF6 hom Verified 2.06312131373411 0.0195505518173714 no 226 0.0200412223372609 64 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CARBOHYDRATE METABOLISM NUCLEUS RSC COMPLEX Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf5p; relocates to the cytosol under hypoxic conditions sucrose catabolic process|nucleotide-excision repair|chromatin remodeling|positive regulation of transcription from RNA polymerase II promoter molecular_function SWI/SNF complex|nucleus
YOR170W_d YOR170W YOR170W hom Dubious 2.06234405294642 0.0195874958603298 no 227 0.019947585545291 106 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene LCB4 Unknown Unknown Unknown
YDL178W YDL178W DLD2 hom Verified 2.06061676687964 0.0196698079371819 no 228 0.0378440236140447 195 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION D-lactate dehydrogenase, located in the mitochondrial matrix lactate metabolic process actin binding|D-lactate dehydrogenase (cytochrome) activity mitochondrion|mitochondrial matrix
YDR178W YDR178W SDH4 hom Verified 2.04245309792318 0.0205533036621675 no 229 0.0312821696922827 159 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain mitochondrial electron transport, succinate to ubiquinone|cellular respiration|tricarboxylic acid cycle succinate dehydrogenase (ubiquinone) activity mitochondrial respiratory chain complex II|mitochondrion
YJR021C YJR021C REC107 hom Verified 2.03195047832676 0.0210793347812314 no 230 0.0202584449010751 130 NA FT CELL CYCLE NUCLEUS|CHROMOSOME Protein involved in early stages of meiotic recombination; involved in coordination between the initiation of recombination and the first division of meiosis; part of a complex (Rec107p-Mei4p-Rec114p) required for ds break formation reciprocal meiotic recombination molecular_function condensed nuclear chromosome
YPL110C YPL110C GDE1 hom Verified 2.03187102392341 0.0210833573235959 no 231 0.0204000461760025 129 NA FT LIPID METABOLISM|SIGNALING|CARBOHYDRATE METABOLISM Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes glycerophospholipid catabolic process glycerophosphocholine phosphodiesterase activity ribosome|cytoplasm
YGL248W YGL248W PDE1 hom Verified 2.02843901741288 0.0212577306670125 no 232 0.0157001819159058 117 NA FT SIGNALING|NUCLEOTIDE METABOLISM Low-affinity cyclic AMP phosphodiesterase, controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation cAMP-mediated signaling 3',5'-cyclic-AMP phosphodiesterase activity cellular_component
YPR193C YPR193C HPA2 hom Verified 2.02763476116492 0.0212987692500262 no 233 0.016464498766327 154 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION Tetrameric histone acetyltransferase with similarity to Gcn5p, Hat1p, Elp3p, and Hpa3p; acetylates histones H3 and H4 in vitro and exhibits autoacetylation activity protein homotetramerization|histone acetylation histone acetyltransferase activity|protein homodimerization activity cytoplasm
YNL116W YNL116W DMA2 hom Verified 2.02474970394871 0.0214465360083301 no 234 0.0345876615602814 169 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION Ubiquitin-protein ligase (E3); controls septin dynamics and the spindle position checkpoint (SPOC) along with functionally redundant ligase Dma1p by regulating the recruitment of Elm1p to the bud neck; regulates levels of the translation initiation factor eIF2 subunit Gcd11p, as well as abundance, localization, and ubiquitination of Cdk inhibitory kinase Swe1p; ortholog of human RNF8 protein, with sequence similarity to human Chfr; contains FHA and RING finger domains establishment of mitotic spindle orientation|protein autoubiquitination|septin ring assembly|mitotic cell cycle spindle assembly checkpoint ubiquitin-protein ligase activity cytoplasm
YNL125C YNL125C ESBP6 hom Verified 2.0205738166527 0.0216619508263053 no 235 0.0191762322137557 159 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane transport monocarboxylic acid transmembrane transporter activity|transporter activity mitochondrion|integral to membrane|endoplasmic reticulum|membrane
YDL073W_p YDL073W YDL073W hom Uncharacterized 2.0173209347759 0.0218310161521683 no 236 0.0357469858980426 192 NA Putative protein of unknown function; YDL073W is not an essential gene biological_process molecular_function cellular_component
YGR056W YGR056W RSC1 hom Verified 2.01611567508298 0.0218939406541949 no 237 0.06484158785271 324 NA FF|FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS RSC COMPLEX Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook double-strand break repair|ATP-dependent chromatin remodeling|regulation of sporulation resulting in formation of a cellular spore|double-strand break repair via nonhomologous end joining|nucleosome disassembly|transcription elongation from RNA polymerase II promoter DNA-dependent ATPase activity RSC complex
YCR023C YCR023C YCR023C hom Verified 2.00950184944624 0.0222419693731164 no 238 0.0187945794821782 147 NA Vacuolar membrane protein of unknown function; member of the multidrug resistance family; YCR023C is not an essential gene biological_process molecular_function fungal-type vacuole membrane|integral to membrane
YER173W YER173W RAD24 hom Verified 1.98804579395429 0.0234033127673564 no 239 0.0269308709302515 129 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein reciprocal meiotic recombination|DNA damage checkpoint|nucleotide-excision repair DNA clamp loader activity Rad17 RFC-like complex|nucleus
YPL165C YPL165C SET6 hom Verified 1.97364565925205 0.0242110240502975 no 240 0.0158113406077175 104 NA SET domain protein of unknown function; deletion heterozygote is sensitive to compounds that target ergosterol biosynthesis, may be involved in compound availability biological_process molecular_function cellular_component
YPL155C YPL155C KIP2 hom Verified 1.95938492281553 0.0250338625133469 no 241 0.0123765423819513 103 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION MITOCHONDRION|CYTOSKELETON Kinesin-related motor protein involved in mitotic spindle positioning, stabilizes microtubules by targeting Bik1p to the plus end; Kip2p levels are controlled during the cell cycle nuclear migration along microtubule|mitotic anaphase B|negative regulation of microtubule depolymerization microtubule motor activity mitochondrion|kinesin complex|cytoplasmic microtubule
YDR162C YDR162C NBP2 hom Verified 1.95869912150696 0.0250740166975098 no 242 0.0810544443613704 393 NA FF|FT PROTEIN PHOSPHORYLATION NUCLEUS Protein involved in the HOG (high osmolarity glycerol) pathway; negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex; interacts with Bck1p and down regulates the cell wall integrity pathway; found in the nucleus and cytoplasm, contains an SH3 domain and a Ptc1p binding domain (PBM) negative regulation of protein kinase activity|response to heat|hyperosmotic response molecular_function nucleus|cytoplasm
YLR372W YLR372W SUR4 hom Verified 1.95809774965668 0.025109271887626 no 243 0.145738792400274 574 NA FF|FT VESICLE-MEDIATED TRANSPORT|KETONE METABOLISM|LIPID METABOLISM ENDOPLASMIC RETICULUM Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis post-Golgi vesicle-mediated transport|fatty acid elongation|fatty acid biosynthetic process|sphingolipid biosynthetic process fatty acid elongase activity integral to membrane|endoplasmic reticulum
YLR431C YLR431C ATG23 hom Verified 1.94876767751283 0.0256615877092398 no 244 0.0322293416561369 193 NA FT PROTEIN LOCALIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Peripheral membrane protein required for the cytoplasm-to-vacuole targeting (Cvt) pathway and efficient macroautophagy; cycles between the phagophore assembly site (PAS) and non-PAS locations; forms a complex with Atg9p and Atg27p protein localization to pre-autophagosomal structure|positive regulation of macroautophagy|CVT pathway molecular_function pre-autophagosomal structure|extrinsic to membrane
YBR092C YBR092C PHO3 hom Verified 1.94804903888678 0.0257045478439908 no 245 0.0171792111699107 125 NA Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin phosphate-containing compound metabolic process|thiamine-containing compound metabolic process acid phosphatase activity cell wall-bounded periplasmic space
YBL028C YBL028C YBL028C hom Verified 1.94140651961819 0.0261044940655823 no 246 0.0368017349846145 116 NA FT NUCLEUS Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis biological_process molecular_function ribosome|nucleolus|nucleus|preribosome, large subunit precursor
YBL056W YBL056W PTC3 hom Verified 1.93594591113544 0.0264371629539905 no 247 0.0222802988528968 174 NA FT CELL CYCLE|SIGNALING|PROTEIN PHOSPHORYLATION NUCLEUS Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress; dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p); role in DNA damage checkpoint inactivation; PTC3 has a paralog, PTC2, that arose from the whole genome duplication inactivation of MAPK activity involved in osmosensory signaling pathway|regulation of cyclin-dependent protein kinase activity|protein dephosphorylation protein serine/threonine phosphatase activity nucleus|cytoplasm
YDR458C YDR458C HEH2 hom Verified 1.93468218921602 0.0265146536566221 no 248 0.0292852867572572 187 NA FT ENDOMEMBRANE SYSTEM|NUCLEUS Inner nuclear membrane (INM) protein; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence; targeting to the INM requires the Srp1p-Kap95p karyopherins and the Ran cycle biological_process molecular_function nuclear envelope
YJR126C YJR126C VPS70 hom Verified 1.93132572740723 0.0267213918579508 no 249 0.0210256405725815 119 NA FT PROTEIN LOCALIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT Protein of unknown function involved in vacuolar protein sorting protein targeting to vacuole molecular_function cellular_component
YBR295W YBR295W PCA1 hom Verified 1.92770402276585 0.0269459757267496 no 250 0.0272406110959885 164 NA FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS PLASMA MEMBRANE Cadmium transporting P-type ATPase; may also have a role in copper and iron homeostasis; stabilized by Cd binding, which prevents ubiquitination; S288C and other lab strains contain a G970R mutation which eliminates Cd transport function cadmium ion transport|cellular iron ion homeostasis|cellular metal ion homeostasis|transmembrane transport copper-transporting ATPase activity|cadmium-exporting ATPase activity|copper ion binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism integral to membrane|plasma membrane
YDL013W YDL013W SLX5 hom Verified 1.92534673152059 0.0270929974777174 no 251 0.0457873863465132 244 NA FT RESPONSE TO DNA DAMAGE NUCLEUS UBIQUITIN LIGASE COMPLEX Subunit of the Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex, stimulated by SUMO-modified substrates; contains a RING domain and two SIMs (SUMO-interacting motifs); forms SUMO-dependent nuclear foci, including DNA repair centers protein sumoylation|telomere maintenance|response to DNA damage stimulus|protein ubiquitination SUMO binding|ubiquitin-protein ligase activity ubiquitin ligase complex|nucleus
YCR076C YCR076C FUB1 hom Verified 1.92467935525184 0.0271347424039409 no 252 0.0433280554367637 212 NA Putative protein of unknown function; interacts physically with multiple subunits of the 20S proteasome and genetically with genes encoding 20S core particle and 19S regulatory particle subunits; exhibits boundary activity which blocks the propagation of heterochromatic silencing; contains a PI31 proteasome regulator domain and sequence similarity with human PSMF1, a proteasome inhibitor; not an essential gene biological_process proteasome binding cellular_component
YKR090W YKR090W PXL1 hom Verified 1.9160447677919 0.0276796988123041 no 253 0.0282052903879201 199 NA FT SIGNALING SITE OF POLARIZED GROWTH Protein that localizes to sites of polarized growth; required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; contains LIM domains and has similarity to metazoan paxillin; relocalizes from bud neck to cytoplasm upon DNA replication stress maintenance of cell polarity|regulation of Rho protein signal transduction Rho GDP-dissociation inhibitor activity incipient cellular bud site|cellular bud|mating projection tip|cellular bud neck|cytoplasm|cellular bud tip
YFR057W_p YFR057W YFR057W hom Uncharacterized 1.91494551687753 0.0277497261021419 no 254 0.0338717640729622 147 NA Putative protein of unknown function biological_process molecular_function cellular_component
YPR071W_p YPR071W YPR071W hom Uncharacterized 1.91160140080456 0.027963669765881 no 255 0.0292130685165042 172 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Putative membrane protein; YPR071W is not an essential gene; YPR071W has paralog YIL029C biological_process molecular_function integral to membrane
YPL271W YPL271W ATP15 hom Verified 1.90912931802369 0.0281227057582403 no 256 0.0428586214430168 169 NA FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS MITOCHONDRION Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated ATP synthesis coupled proton transport hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism proton-transporting ATP synthase complex, catalytic core F(1)|mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase, central stalk
YHL040C YHL040C ARN1 hom Verified 1.90470402033203 0.0284092780571378 no 257 0.0195814657244235 84 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE ARN family transporter for siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores; protein increases in abundance and relocalizes to the vacuole upon DNA replication stress siderophore transport siderophore transmembrane transporter activity endosome|integral to membrane|plasma membrane|cytoplasmic membrane-bounded vesicle
YER056C YER056C FCY2 hom Verified 1.89951103739202 0.0287486584025895 no 258 0.0169846066719258 99 NA FT PLASMA MEMBRANE Purine-cytosine permease; mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation; relative distribution to the vacuole increases upon DNA replication stress cytosine transport|cytidine transport|purine nucleobase transport|transmembrane transport nucleobase transmembrane transporter activity|cytidine transmembrane transporter activity integral to membrane|plasma membrane
YBL059W_p YBL059W YBL059W hom Uncharacterized 1.88775651430739 0.0295293227649754 no 259 0.0386891067438109 177 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YBL059W has a paralog, YER093C-A, that arose from the whole genome duplication biological_process molecular_function mitochondrion
YPR134W YPR134W MSS18 hom Verified 1.8835207519479 0.0298149151179672 no 260 0.0315900510122223 217 NA FT RNA PROCESSING MITOCHONDRION Nuclear encoded protein needed for efficient splicing of mitochondrial COX1 aI5beta intron; mss18 mutations block cleavage of 5' exon - intron junction; phenotype of intronless strain suggests additional functions Group I intron splicing molecular_function mitochondrion
YIL139C YIL139C REV7 hom Verified 1.87844771486386 0.030159971659778 no 261 0.0255857525257623 144 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION|CHROMOSOME Accessory subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair error-prone translesion synthesis|error-free translesion synthesis DNA-directed DNA polymerase activity nuclear chromatin|mitochondrion|zeta DNA polymerase complex
YJL107C_p YJL107C YJL107C hom Uncharacterized 1.87828014743121 0.0301714254625429 no 262 0.0219881378756381 158 NA Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi biological_process molecular_function cellular_component
YLR248W YLR248W RCK2 hom Verified 1.87145065705463 0.0306413215363905 no 263 0.0332852850785273 166 NA FT CELL CYCLE|SIGNALING|PROTEIN PHOSPHORYLATION|RESPONSE TO OXIDATIVE STRESS Protein kinase involved in response to oxidative and osmotic stress; identified as suppressor of S. pombe cell cycle checkpoint mutations; similar to CaM (calmodulin) kinases; RCK2 has a paralog, RCK1, that arose from the whole genome duplication cellular response to oxidative stress|protein phosphorylation|osmosensory signaling pathway|regulation of meiosis protein serine/threonine kinase activity|protein kinase activity cytoplasm
YCR036W YCR036W RBK1 hom Verified 1.87035965819096 0.030716945066581 no 264 0.0639999256279691 300 NA FT CARBOHYDRATE METABOLISM NUCLEUS Putative ribokinase D-ribose metabolic process ribokinase activity|ATP binding nucleus|cytoplasm
YER090W YER090W TRP2 hom Verified 1.86485424441323 0.0311009187267267 no 265 0.231055128030907 859 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p tryptophan biosynthetic process anthranilate synthase activity anthranilate synthase complex|cytoplasm
YHR087W YHR087W RTC3 hom Verified 1.86152643569807 0.03133493550351 no 266 0.048414592440083 257 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1); null mutation suppresses cdc13-1 temperature sensitivity; protein abundance increases in response to DNA replication stress RNA metabolic process molecular_function nucleus|cytoplasm
YAL021C YAL021C CCR4 hom Verified 1.8559235505212 0.031732227823439 no 267 0.066393558304902 373 NA FF|FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RNA PROCESSING NUCLEUS RNA POL II, HOLOENZYME Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|DNA replication checkpoint|nuclear-transcribed mRNA poly(A) tail shortening|traversing start control point of mitotic cell cycle|replication fork protection|transcription elongation from RNA polymerase II promoter|DNA replication 3'-5'-exoribonuclease activity CCR4-NOT core complex|cytoplasmic mRNA processing body|Cdc73/Paf1 complex|cytoplasm
YDR264C YDR264C AKR1 hom Verified 1.85544768787241 0.0317661614409781 no 268 0.0863017460358697 380 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats; AKR1 has a paralog, AKR2, that arose from the whole genome duplication protein targeting to membrane|regulation of endocytosis|regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion|protein palmitoylation palmitoyltransferase activity integral to membrane|Golgi apparatus|membrane
YDR005C YDR005C MAF1 hom Verified 1.85465460068729 0.0318227828585419 no 269 0.0441741258583497 226 NA FT NUCLEUS Highly conserved negative regulator of RNA polymerase III; binds to the N-terminal domain of the Rpc160p subunit of Pol III to prevent closed-complex formation; localization and activity are regulated by phosphorylation, mediated by TORC1, protein kinase A, and Sch9p; localizes to cytoplasm during vegetative growth and translocates to the nucleus and nucleolus under stress conditions negative regulation of transcription from RNA polymerase III promoter RNA polymerase III core binding nucleolus|nucleus|cytoplasm
YOL104C YOL104C NDJ1 hom Verified 1.85008186319862 0.0321508757812037 no 270 0.0247349494109993 171 NA FT CELL CYCLE NUCLEUS|CHROMOSOME Meiosis-specific telomere protein, required for bouquet formation, effective homolog pairing, ordered cross-over distribution, sister chromatid cohesion at meiotic telomeres, chromosomal segregation and telomere-led rapid prophase movement meiotic telomere clustering|synapsis|attachment of telomeric heterochromatin to nuclear envelope|regulation of reciprocal meiotic recombination|reciprocal meiotic recombination telomeric DNA binding nuclear chromosome, telomeric region
YLR057W YLR057W MNL2 hom Verified 1.84864900511172 0.0322542558112145 no 271 0.0398314601102761 210 NA FT PROTEOLYSIS ENDOPLASMIC RETICULUM Putative mannosidase involved in ER-associated protein degradation; localizes to the endoplasmic reticulum; sequence similarity with seven-hairpin glycosidase (GH47) family members, such as Mns1p and Mnl1p, that hydrolyze 1,2-linked alpha-D-mannose residues; non-essential gene ER-associated protein catabolic process molecular_function endoplasmic reticulum
YIR028W YIR028W DAL4 hom Verified 1.84660832708443 0.0324019632333429 no 272 0.0281565137926746 168 NA Allantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation allantoin catabolic process|allantoin transport allantoin uptake transmembrane transporter activity integral to membrane|membrane
YDR256C YDR256C CTA1 hom Verified 1.84528662111213 0.0324979278155332 no 273 0.0297270081137856 168 NA FT OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS MITOCHONDRION Catalase A, breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation response to reactive oxygen species|age-dependent response to reactive oxygen species|hydrogen peroxide catabolic process catalase activity peroxisomal matrix|mitochondrial matrix
YJL126W YJL126W NIT2 hom Verified 1.84525062287829 0.0325005448013413 no 274 0.032079798643841 204 NA Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member biological_process hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds cellular_component
YGL241W YGL241W KAP114 hom Verified 1.83941762111262 0.0329268921480379 no 275 0.0325030728090713 155 NA FT PROTEIN LOCALIZATION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS Karyopherin, responsible for nuclear import of specific proteins; cargoes include Spt15p, Sua7p, histones H2A and H2B, and Nap1p; amino terminus shows similarity to those of other importins, particularly Cse1p; localization is primarily nuclear; function is regulated by sumoylation; protein abundance increases in response to DNA replication stress protein import into nucleus|transcription factor import into nucleus protein transporter activity integral to membrane|nucleus|cytoplasm
YJR060W YJR060W CBF1 hom Verified 1.83926001207466 0.0329384758064972 no 276 0.0542236578483026 295 NA FF|FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|CHROMOSOME SEGREGATION NUCLEUS|MITOCHONDRION|CHROMOSOME KINETOCHORE Dual function helix-loop-helix protein; binds the motif CACRTG present at several sites including MET gene promoters and centromere DNA element I (CDEI); affects nucleosome positioning at this motif; associates with other transcription factors such as Met4p and Isw1p to mediate transcriptional activation or repression; associates with kinetochore proteins and required for efficient chromosome segregation; protein abundance increases in response to DNA replication stress regulation of transcription from RNA polymerase II promoter in response to methionine|negative regulation of transcription from RNA polymerase II promoter|methionine biosynthetic process|chromosome segregation|Unknown|chromatin remodeling|negative regulation of ceramide biosynthetic process by negative regulation of transcription from RNA Polymerase II promoter RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor binding transcription factor activity|RNA polymerase II repressing transcription factor binding|centromeric DNA binding chromosome, centromeric region|mitochondrion|nucleus|kinetochore
YPL136W_d YPL136W YPL136W hom Dubious 1.83511402619517 0.0332443980561383 no 277 0.04271170264074 207 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene GIP3/YPL137C Unknown Unknown Unknown
YOL098C_p YOL098C YOL098C hom Uncharacterized 1.82767837950303 0.0337989174038511 no 278 0.0331214198212681 211 NA FT PROTEOLYSIS Putative metalloprotease biological_process molecular_function cytoplasm
YOL125W YOL125W TRM13 hom Verified 1.82067924394198 0.0343278145479767 no 279 0.0153807309604099 106 NA FT RNA PROCESSING NUCLEUS 2'-O-methyltransferase responsible for modification of tRNA at position 4; C-terminal domain has similarity to Rossmann-fold (RFM) superfamily of RNA methyltransferases tRNA methylation tRNA methyltransferase activity nucleus|cytoplasm
YMR054W YMR054W STV1 hom Verified 1.81771066347059 0.0345541835311406 no 280 0.0356922193276513 234 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Subunit a of the vacuolar-ATPase V0 domain, one of two isoforms (Stv1p and Vph1p); Stv1p is located in V-ATPase complexes of the Golgi and endosomes while Vph1p is located in V-ATPase complexes of the vacuole vacuolar acidification proton-transporting ATPase activity, rotational mechanism vacuolar proton-transporting V-type ATPase, V0 domain|late endosome|integral to membrane|Golgi apparatus
YML009W-B_d YML009W-B YML009W-B hom Dubious 1.80812028400738 0.0352938909352788 no 281 0.0368626896207243 222 NA Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition Unknown Unknown Unknown
YOL070C YOL070C NBA1 hom Verified 1.80592832800973 0.0354647677769463 no 282 0.0385586519496288 206 NA FT SITE OF POLARIZED GROWTH Protein of unknown function, localizes to the bud neck and cytoplasm; interacts with Nap1p; may interact with ribosomes, based on co-purification experiments; potential Cdc28p substrate biological_process molecular_function ribosome|cellular bud neck|cytoplasm
YMR087W YMR087W YMR087W hom Verified 1.80426126238872 0.0355951797372212 no 283 0.0345083074249103 209 NA FT RNA PROCESSING Putative ADP-ribose-1''-monophosphatase that converts ADP-ribose-1''-monophosphate to ADP-ribose; may have a role in tRNA splicing; contains an A1pp domain tRNA splicing, via endonucleolytic cleavage and ligation phosphatase activity cellular_component
YKR017C YKR017C HEL1 hom Verified 1.80015524198393 0.0359180644460433 no 284 0.0365826490082616 197 NA RING finger ubiquitin ligase (E3); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU) biological_process molecular_function cellular_component
YKR035C_d YKR035C OPI8 hom Dubious 1.79598917663427 0.0362481191977172 no 285 0.0635093437074033 268 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene DID2/YKR035W-A Unknown Unknown Unknown
YLR387C YLR387C REH1 hom Verified 1.79192252430439 0.0365726886738177 no 286 0.0509103828803274 190 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS RIBOSOME Cytoplasmic 60S subunit biogenesis factor, associates with pre-60S particles; similar to Rei1p and shares partially redundant function in cytoplasmic 60S subunit maturation; contains dispersed C2H2 zinc finger domains ribosomal large subunit biogenesis|budding cell bud growth molecular_function cytosolic large ribosomal subunit|preribosome, large subunit precursor|cytoplasm
YOR173W YOR173W DCS2 hom Verified 1.78591607444678 0.0370564239424786 no 287 0.0364999247504873 193 NA Non-essential, stress induced regulatory protein; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway; mutant has increased aneuploidy tolerance deadenylation-dependent decapping of nuclear-transcribed mRNA m7G(5')pppN diphosphatase activity cytoplasmic mRNA processing body|cytoplasm
YMR155W_p YMR155W YMR155W hom Uncharacterized 1.7770119046557 0.0377831405830094 no 288 0.0357613860812113 182 NA Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen biological_process molecular_function integral to membrane
YJL057C YJL057C IKS1 hom Verified 1.77397410741939 0.0380337166476262 no 289 0.0367724379994384 170 NA FT PROTEIN PHOSPHORYLATION Protein kinase of unknown cellular role; putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts with an N-terminal fragment of Sst2p protein phosphorylation protein kinase activity cellular_component
YLR414C YLR414C PUN1 hom Verified 1.7732886398346 0.0380904452534261 no 290 0.0221602738851335 122 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL WALL ORG/BIOGENESIS PLASMA MEMBRANE Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress fungal-type cell wall organization|protein oligomerization molecular_function integral to membrane|membrane raft|plasma membrane|cellular bud|cytoplasm
YKR044W YKR044W UIP5 hom Verified 1.77218072064732 0.0381822814375094 no 291 0.0318274511959148 139 NA FT ENDOMEMBRANE SYSTEM|NUCLEUS Protein of unknown function that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates biological_process molecular_function nuclear envelope
YFR043C YFR043C IRC6 hom Verified 1.7669087851558 0.0386217527573803 no 292 0.0407725739330685 231 NA Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci biological_process molecular_function cellular_component
YLR451W YLR451W LEU3 hom Verified 1.76565696968519 0.0387267080166099 no 293 0.0363124487063904 190 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Zinc-knuckle transcription factor, repressor and activator; regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; acts as a repressor in leucine-replete conditions and as an activator in the presence of alpha-isopropylmalate, an intermediate in leucine biosynthesis that accumulates during leucine starvation negative regulation of transcription from RNA polymerase II promoter|Unknown|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YMR053C YMR053C STB2 hom Verified 1.76532930748068 0.0387542183495806 no 294 0.0334220196138094 250 NA FT NUCLEUS|CHROMOSOME Protein that interacts with Sin3p in a two-hybrid assay and is part of a large protein complex with Sin3p and Stb1p biological_process molecular_function Sin3-type complex
YBL042C YBL042C FUI1 hom Verified 1.7624457222222 0.038997009666453 no 295 0.0523577349331743 354 NA FF|FT PLASMA MEMBRANE High affinity uridine permease, localizes to the plasma membrane; also mediates low but significant transport of the cytotoxic nucleoside analog 5-fluorouridine; not involved in uracil transport; relative distribution to the vacuole increases upon DNA replication stress uridine transport|transmembrane transport uridine transmembrane transporter activity integral to membrane|plasma membrane
YLR435W YLR435W TSR2 hom Verified 1.76119059822163 0.0391030744042876 no 296 0.0368161441965009 230 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Protein with a potential role in pre-rRNA processing maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function nucleus|cytoplasm
YPL184C YPL184C MRN1 hom Verified 1.75840459567885 0.0393393458696367 no 297 0.0412953282387497 225 NA FT TRANSLATION RNA-binding protein that may be involved in translational regulation; binds specific categories of mRNAs, including those that contain upstream open reading frames (uORFs) and internal ribosome entry sites (IRES); interacts genetically with chromatin remodelers and splicing factors, linking chromatin state, splicing and as a result mRNA maturation biological_process molecular_function cytoplasm
YPL099C YPL099C AIM43 hom Verified 1.75346231414798 0.0397613414284999 no 298 0.0301772952660698 162 NA FT MITOCHONDRION Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss biological_process molecular_function mitochondrion
YDR525W_d YDR525W API2 hom Dubious 1.75322974008254 0.0397812900304145 no 299 0.0668850930551239 272 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 26% of ORF overlaps the dubious ORF YDR524C-A; insertion mutation in a cdc34-2 mutant background causes altered bud morphology Unknown Unknown Unknown
YBL009W YBL009W ALK2 hom Verified 1.75294071230063 0.0398060921814213 no 300 0.0318528691120082 169 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; ALK2 has a paralog, ALK1, that arose from the whole genome duplication; similar to mammalian haspins meiosis|mitosis|protein phosphorylation protein serine/threonine kinase activity|protein kinase activity cellular_component
YKL221W YKL221W MCH2 hom Verified 1.7474741028145 0.0402775666335374 no 301 0.0484906640079125 148 NA Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport transport monocarboxylic acid transmembrane transporter activity|transporter activity integral to membrane|membrane
YBR218C YBR218C PYC2 hom Verified 1.74520359222168 0.040474718088019 no 302 0.0486659055030224 234 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc1p; mutations in the human homolog are associated with lactic acidosis; PYC2 has a paralog, PYC1, that arose from the whole genome duplication NADPH regeneration|gluconeogenesis pyruvate carboxylase activity cytosol
YDR151C YDR151C CTH1 hom Verified 1.74485060895081 0.0405054383473818 no 303 0.0436328696230954 197 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS NUCLEUS Member of the CCCH zinc finger family; has similarity to mammalian Tis11 protein, which activates transcription and also has a role in mRNA degradation; may function with Tis11p in iron homeostasis nuclear-transcribed mRNA catabolic process|cellular iron ion homeostasis mRNA binding nucleus
YFR047C YFR047C BNA6 hom Verified 1.74379839218115 0.040597125476082 no 304 0.0369177434744584 176 NA FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM NUCLEUS Quinolinate phosphoribosyl transferase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p de novo NAD biosynthetic process from tryptophan nicotinate-nucleotide diphosphorylase (carboxylating) activity nucleus|cytoplasm
YBR283C YBR283C SSH1 hom Verified 1.73835269944438 0.0410743428990375 no 305 0.041264076296967 184 NA FT PROTEIN LOCALIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Subunit of the Ssh1 translocon complex; Sec61p homolog involved in co-translational pathway of protein translocation; not essential SRP-dependent cotranslational protein targeting to membrane protein transmembrane transporter activity|signal sequence binding integral to membrane|Ssh1 translocon complex
YJL217W YJL217W REE1 hom Verified 1.73694096765796 0.0411987956112875 no 306 0.0405289480271048 242 NA Cytoplasmic protein involved in the regulation of enolase (ENO1); mRNA expression is induced by calcium shortage, copper deficiency (via Mac1p) and the presence of galactose (via Gal4p); mRNA expression is also regulated by the cell cycle biological_process molecular_function cytoplasm
YGL261C_p YGL261C PAU11 hom Uncharacterized 1.736541935635 0.0412340280677701 no 307 0.0391497114607507 195 NA Putative protein of unknown function and member of the seripauperin multigene family encoded mainly in subtelomeric regions; mRNA expression appears to be regulated by SUT1 and UPC2 biological_process molecular_function cellular_component
YBR296C-A_p YBR296C-A YBR296C-A hom Uncharacterized 1.73080050497187 0.0417436759061153 no 308 0.0514734900813866 272 NA Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YOL126C YOL126C MDH2 hom Verified 1.73011634272594 0.0418047454585516 no 309 0.0397872630250889 223 NA FT PROTEIN LOCALIZATION|KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|PEROXISOME ORGANIZATION Cytoplasmic malate dehydrogenase, one of three isozymes that catalyze interconversion of malate and oxaloacetate; involved in the glyoxylate cycle and gluconeogenesis during growth on two-carbon compounds; interacts with Pck1p and Fbp1 protein import into peroxisome matrix|gluconeogenesis|malate metabolic process L-malate dehydrogenase activity cytosol|cytoplasm
YER151C YER151C UBP3 hom Verified 1.72890845040829 0.0419127407098183 no 310 0.0652105830240878 321 NA FT VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS Ubiquitin-specific protease involved in transport and osmotic response; interacts with Bre5p to co-regulate anterograde and retrograde transport between the ER and Golgi; involved in transcription elongation in response to osmostress through phosphorylation at Ser695 by Hog1p; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin; also has mRNA binding activity; protein abundance increases in response to DNA replication stress protein deubiquitination|ribophagy|regulation of ER to Golgi vesicle-mediated transport|regulation of response to osmotic stress ubiquitin-specific protease activity|mRNA binding cytoplasm
YDR479C YDR479C PEX29 hom Verified 1.72747760427835 0.0420409619632206 no 311 0.045466834221468 217 NA FT PEROXISOME ORGANIZATION Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress peroxisome organization molecular_function integral to membrane|peroxisomal membrane
YER132C YER132C PMD1 hom Verified 1.72660445427713 0.0421193627164755 no 312 0.046408327559915 235 NA FT CELL CYCLE Protein with an N-terminal kelch-like domain, putative negative regulator of early meiotic gene expression; required, with Mds3p, for growth under alkaline conditions sporulation resulting in formation of a cellular spore molecular_function cytoplasm
YKR067W YKR067W GPT2 hom Verified 1.72342770289542 0.0424056043817176 no 313 0.0562322662074647 289 NA FT LIPID METABOLISM ENDOPLASMIC RETICULUM Glycerol-3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis; the most conserved motifs and functionally relevant residues are oriented towards the ER lumen phospholipid biosynthetic process glycerol-3-phosphate O-acyltransferase activity|glycerone-phosphate O-acyltransferase activity integral to membrane|lipid particle|endoplasmic reticulum|cytoplasm
YER142C YER142C MAG1 hom Verified 1.72175966492357 0.042556532025618 no 314 0.0297354393407895 192 NA FT RESPONSE TO DNA DAMAGE NUCLEUS 3-methyl-adenine DNA glycosylase; involved in protecting DNA against alkylating agents; initiates base excision repair by removing damaged bases to create abasic sites that are subsequently repaired; protein abundance increases in response to DNA replication stress base-excision repair, AP site formation|DNA dealkylation involved in DNA repair alkylbase DNA N-glycosylase activity nucleus
YCL032W YCL032W STE50 hom Verified 1.72070823937459 0.0426518902503102 no 315 0.0511057126897445 248 NA FT CELL CYCLE|SIGNALING Protein involved in mating response, invasive/filamentous growth, and osmotolerance, acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction pheromone-dependent signal transduction involved in conjugation with cellular fusion|MAPK cascade involved in osmosensory signaling pathway|osmosensory signaling pathway via Sho1 osmosensor|signal transduction involved in filamentous growth|cellular response to heat SAM domain binding|protein kinase regulator activity cytoplasm
YLR367W YLR367W RPS22B hom Verified 1.71736483893312 0.0429562659310163 no 316 0.0382291959581454 181 NA FT TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic small ribosomal subunit
YOR311C YOR311C DGK1 hom Verified 1.71636832424213 0.0430473251451829 no 317 0.0297555745554785 163 NA FT VESICLE-MEDIATED TRANSPORT|KETONE METABOLISM|LIPID METABOLISM ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Diacylglycerol kinase, localized to the endoplasmic reticulum (ER); overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation; contains a CTP transferase domain phosphatidic acid biosynthetic process diacylglycerol kinase activity integral to endoplasmic reticulum membrane|integral to membrane
YKL044W_p YKL044W YKL044W hom Uncharacterized 1.71143377308686 0.0435005335283019 no 318 0.0333896757803606 178 NA Protein of unknown function; mRNA identified as translated by ribosome profiling data biological_process molecular_function cellular_component
YPL223C YPL223C GRE1 hom Verified 1.70959711656221 0.0436701996109101 no 319 0.0523188956841812 206 NA Hydrophilin essential in dessication-rehydration process; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway biological_process molecular_function cytoplasm
YEL061C YEL061C CIN8 hom Verified 1.70722336901944 0.0438902715228463 no 320 0.0526716106379888 302 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION NUCLEUS|MITOCHONDRION|CHROMOSOME|CYTOSKELETON KINETOCHORE Kinesin motor protein involved in mitotic spindle assembly and chromosome segregation mitotic anaphase B|microtubule depolymerization|spindle pole body separation|mitotic spindle organization in nucleus|mitotic sister chromatid segregation plus-end-directed microtubule motor activity|minus-end-directed microtubule motor activity spindle microtubule|kinesin complex|mitochondrion|condensed nuclear chromosome kinetochore|kinetochore microtubule|astral microtubule
YGL190C YGL190C CDC55 hom Verified 1.7054662142557 0.0440537541301186 no 321 0.0690787499408859 328 NA FT CELL CYCLE|SIGNALING NUCLEUS|SITE OF POLARIZED GROWTH Non-essential regulatory subunit B of protein phosphatase 2A (PP2A); localization to the cytoplasm requires Zds1p and Zds2p and promotes mitotic entry; localization to the nucleus prevents mitotic exit; required for correct nuclear division and chromosome segregation in meiosis; maintains nucleolar sequestration of Cdc14p during early meiosis; limits formation of PP2A-Rts1p holocomplexes to ensure timely dissolution of sister chromosome cohesion negative regulation of exit from mitosis|positive regulation of G2/M transition of mitotic cell cycle|cell shape checkpoint|protein dephosphorylation protein phosphatase type 2A regulator activity nucleus|cellular bud neck|cytoplasm|cellular bud tip
YCR106W YCR106W RDS1 hom Verified 1.7041334206195 0.0441780820879911 no 322 0.0351063821222437 274 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Putative zinc cluster transcription factor; involved in conferring resistance to cycloheximide response to xenobiotic stimulus sequence-specific DNA binding|DNA binding nucleus
YGR100W YGR100W MDR1 hom Verified 1.70310313465104 0.0442743847166462 no 323 0.0516370723245051 182 NA FT PROTEIN LOCALIZATION|SIGNALING|NUCLEOTIDE METABOLISM Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function intracellular protein transport Rab GTPase activator activity cytoplasm
YOL112W YOL112W MSB4 hom Verified 1.70307325895042 0.0442771797728792 no 324 0.0458989178966701 251 NA FT SIGNALING|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH GTPase-activating protein of the Ras superfamily that acts primarily on Sec4p, localizes to the bud site and bud tip, has similarity to Msb3p; msb3 msb4 double mutation causes defects in secretion and actin organization actin filament organization Rab GTPase activator activity incipient cellular bud site|polarisome|cellular bud tip
YPR098C YPR098C YPR098C hom Verified 1.70083626566969 0.0444868686330018 no 325 0.0592457866999409 281 NA FT MITOCHONDRION Protein of unknown function, localized to the mitochondrial outer membrane biological_process molecular_function mitochondrial outer membrane|mitochondrion
YKR089C YKR089C TGL4 hom Verified 1.69933199075958 0.0446283240930134 no 326 0.0456873635839835 203 NA FT LIPID METABOLISM|CELL DIVISION Multifunctional triacylglycerol lipase, steryl ester hydrolase, and Ca2+-independent phospholipase A2; catalyzes acyl-CoA dependent acylation of LPA to PA; required with Tgl3p for timely bud formation; phosphorylated and activated by Cdc28p phospholipid metabolic process|triglyceride catabolic process|triglyceride mobilization|cell budding lysophosphatidic acid acyltransferase activity|triglyceride lipase activity|calcium-independent phospholipase A2 activity|sterol esterase activity lipid particle
YML107C YML107C PML39 hom Verified 1.69671987152136 0.0448748169734153 no 327 0.0399692727066154 165 NA FT RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE Protein required for nuclear retention of unspliced pre-mRNAs along with Mlp1p and Pml1p; anchored to nuclear pore complex via Mlp1p and Mlp2p; found with the subset of nuclear pores farthest from the nucleolus; may interact with ribosomes maintenance of RNA location molecular_function ribosome|nuclear pore
YIL113W YIL113W SDP1 hom Verified 1.69571939332312 0.0449695170100747 no 328 0.0526527679418678 251 NA FT SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION NUCLEUS Stress-inducible dual-specificity MAP kinase phosphatase, negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock inactivation of MAPK activity involved in cell wall biogenesis|MAPK cascade involved in cell wall biogenesis MAP kinase tyrosine phosphatase activity nucleus|cytoplasm
YDR323C YDR323C PEP7 hom Verified 1.69563673325626 0.0449773483689181 no 329 0.103687959148542 483 NA FF|FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance Golgi to vacuole transport|vacuole inheritance|vesicle fusion|vesicle docking involved in exocytosis|Golgi to endosome transport phosphatidylinositol-3-phosphate binding external side of endosome membrane|cytoplasm
YHR057C YHR057C CPR2 hom Verified 1.69538189618354 0.0450014989867804 no 330 0.0435872406018403 177 NA Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway biological_process peptidyl-prolyl cis-trans isomerase activity cellular_component
YLR289W YLR289W GUF1 hom Verified 1.69525707585636 0.0450133318740186 no 331 0.0550036136221933 263 NA FT TRANSLATION|NUCLEOTIDE METABOLISM MITOCHONDRION RIBOSOME Mitochondrial matrix GTPase that associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in translational fidelity; similar to bacterial LepA elongation factor positive regulation of translation ribosome binding|GTPase activity mitochondrion|mitochondrial ribosome|mitochondrial matrix
YJL055W_p YJL055W YJL055W hom Uncharacterized 1.69413399001501 0.0451199123647957 no 332 0.0464825277867527 232 NA FT NUCLEUS Putative protein of unknown function, proposed to be involved in the metabolism of purine and pyrimidine base analogues; deletion mutants are sensitive to HAP and AHA; overexpression confers resistance to 5-FOA and 5-FU response to chemical stimulus|response to purine-containing compound molecular_function nucleus|cytoplasm
YIL013C YIL013C PDR11 hom Verified 1.69260505745421 0.0452653338870218 no 333 0.0474239763592917 247 NA FT NUCLEOTIDE METABOLISM ATP-binding cassette (ABC) transporter, multidrug transporter involved in multiple drug resistance; mediates sterol uptake when sterol biosynthesis is compromised; regulated by Pdr1p; required for anaerobic growth sterol transport ATPase activity, coupled to transmembrane movement of substances integral to membrane|membrane
YFL013C YFL013C IES1 hom Verified 1.68982189098811 0.0455310172233175 no 334 0.0635378808273429 269 NA FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Subunit of the INO80 chromatin remodeling complex nucleosome mobilization molecular_function nucleus|Ino80 complex
YMR090W_p YMR090W YMR090W hom Uncharacterized 1.68860667187209 0.0456474156266897 no 335 0.0539366644264362 247 NA Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; GFP-fusion protein localizes to the cytoplasm; up-regulated in response to the fungicide mancozeb; not essential for viability biological_process molecular_function cytoplasm
YPR132W YPR132W RPS23B hom Verified 1.68796627118572 0.0457088518702094 no 336 0.0423481939955022 203 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23B has a paralog, RPS23A, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|regulation of translational fidelity structural constituent of ribosome cytosolic small ribosomal subunit
YGR122W YGR122W YGR122W hom Verified 1.68699081178672 0.0458025593641949 no 337 0.0743982959093558 409 NA FF|FT TRANSCRIPTION FROM RNA POL II Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress negative regulation of transcription from RNA polymerase II promoter|nuclear-transcribed mRNA catabolic process, non-stop decay molecular_function cytoplasm
YLR415C_p YLR415C YLR415C hom Uncharacterized 1.6859069681799 0.0459068597984209 no 338 0.0473767124532337 208 NA FT MITOCHONDRION Putative protein of unknown function; YLR415C is not an essential gene biological_process molecular_function cellular_component
YOL106W_d YOL106W YOL106W hom Dubious 1.67952297372802 0.0465250826602556 no 339 0.0378301109295038 184 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YHL024W YHL024W RIM4 hom Verified 1.67491318065182 0.0469756335718733 no 340 0.0611298832185263 227 NA FT CELL CYCLE Putative RNA-binding protein required for the expression of early and middle sporulation genes meiosis|reciprocal meiotic recombination|sporulation resulting in formation of a cellular spore|premeiotic DNA replication RNA binding cytoplasm
YKR028W YKR028W SAP190 hom Verified 1.67358462925218 0.0471061307177658 no 341 0.0468743029075698 217 NA FT CELL CYCLE|RNA PROCESSING|SIGNALING Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication TOR signaling cascade|dephosphorylation|G1/S transition of mitotic cell cycle|tRNA wobble uridine modification molecular_function cytoplasm
YML004C YML004C GLO1 hom Verified 1.67342479443959 0.0471218500816216 no 342 0.0492056640825845 241 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Monomeric glyoxalase I, catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione; expression regulated by methylglyoxal levels and osmotic stress methylglyoxal catabolic process to D-lactate|glutathione metabolic process lactoylglutathione lyase activity nucleus|cytoplasm
YIL119C YIL119C RPI1 hom Verified 1.67156809799411 0.0473047599715176 no 343 0.0395970625596057 191 NA FT SIGNALING NUCLEUS Transcription factor with allelic differences between S288C and Sigma1278b; mediates fermentation stress tolerance by modulating cell wall integrity; overexpression suppresses heat shock sensitivity of wild-type RAS2 overexpression and also suppresses cell lysis defect of mpk1 mutation; allele from S288c can confer fMAPK pathway independent transcription of FLO11; S288C and Sigma1278b alleles differ in number of tandem repeats within ORF fungal-type cell wall biogenesis|Ras protein signal transduction|positive regulation of transcription from RNA polymerase II promoter small GTPase regulator activity nucleus
YHR189W YHR189W PTH1 hom Verified 1.67156654761327 0.0473049129425681 no 344 0.0429459325296424 250 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION One of two (see also PTH2) mitochondrially-localized peptidyl-tRNA hydrolases; dispensable for respiratory growth on rich medium, but required for respiratory growth on minimal medium mitochondrial translation aminoacyl-tRNA hydrolase activity mitochondrion
YHR014W YHR014W SPO13 hom Verified 1.67082418780878 0.0473782047303419 no 345 0.027553773381528 160 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Meiosis-specific protein, involved in maintaining sister chromatid cohesion during meiosis I as well as promoting proper attachment of kinetochores to the spindle during meiosis I and meiosis II protein localization to chromosome, centromeric region|meiotic sister chromatid cohesion|positive regulation of sister chromatid cohesion molecular_function nucleus|condensed nuclear chromosome, centromeric region
YGL253W YGL253W HXK2 hom Verified 1.66984206412102 0.0474753077446595 no 346 0.0496523363000553 246 NA FT CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS|MITOCHONDRION Hexokinase isoenzyme 2; catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene; phosphorylation/dephosphorylation at serine-14 by protein kinase Snf1p and protein phosphatase Glc7p-Reg1p regulates nucleocytoplasmic shuttling of Hxk2p; HXK2 has a paralog, HXK1, that arose from the whole genome duplication replicative cell aging|fructose import|regulation of transcription by glucose|glucose import|mannose metabolic process|glycolysis|glucose metabolic process|regulation of cell size|fructose metabolic process hexokinase activity cytosol|mitochondrion|nucleus
YPL219W YPL219W PCL8 hom Verified 1.66823016354096 0.0476350226096715 no 347 0.0604929602679378 252 NA FT CELL CYCLE|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylation negative regulation of glycogen biosynthetic process cyclin-dependent protein kinase regulator activity cyclin-dependent protein kinase holoenzyme complex
YBR021W YBR021W FUR4 hom Verified 1.66555067484052 0.0479014712313809 no 348 0.0940578113255535 444 NA FF|FT PLASMA MEMBRANE Plasma membrane localized uracil permease; expression is tightly regulated by uracil levels and environmental cues; conformational alterations induced by unfolding or substrate binding result in Rsp5p-mediated ubiquitination and degradation uracil transport|transmembrane transport uracil:cation symporter activity integral to membrane|membrane raft|plasma membrane
YPR004C YPR004C AIM45 hom Verified 1.66372036701667 0.0480841620935571 no 349 0.0459594625998574 270 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-alpha; interacts with frataxin, Yfh1p; null mutant displays elevated frequency of mitochondrial genome loss; may have a role in oxidative stress response biological_process molecular_function mitochondrion
YBR061C YBR061C TRM7 hom Verified 1.66109956262025 0.048346726155336 no 350 0.0463784899312749 271 NA FT RNA PROCESSING|TRANSLATION 2'-O-ribose methyltransferase; methylates the 2'-O-ribose of tRNA-Phe, tRNA-Trp, and tRNA-Leu at positions C32 and N34 of the tRNA anticodon loop; crucial biological role likely modification of tRNA-Phe; interacts with Trm732p and Rtt10p in 2'-O-methylation of C32 and N34 substrate tRNAs, respectively cytoplasmic translation|tRNA methylation tRNA methyltransferase activity cytoplasm
YKR106W YKR106W GEX2 hom Verified 1.65994329119914 0.0484629306675486 no 351 0.0401338614310997 179 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Proton:glutathione antiporter localized to the vacuolar and plasma membranes; expressed at a very low level; almost identical to paralog Gex1p; potential role in resistance to oxidative stress and modulation of the PKA pathway glutathione transmembrane transport solute:hydrogen antiporter activity integral to membrane|plasma membrane|vacuolar membrane
YNR075W YNR075W COS10 hom Verified 1.65987682112788 0.0484696176489373 no 352 0.0384590533770921 220 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins endocytosis molecular_function nuclear envelope|integral to membrane|endoplasmic reticulum|cytoplasm
YDL010W YDL010W GRX6 hom Verified 1.65853635873826 0.0486046275671936 no 353 0.0457222219974957 186 NA FT RESPONSE TO OXIDATIVE STRESS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Cis-golgi localized monothiol glutaredoxin, binds Fe-S cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; GRX6 has a paralog, GRX7, that arose from the whole genome duplication cellular response to oxidative stress glutathione-disulfide reductase activity|iron ion binding|protein homodimerization activity|2 iron, 2 sulfur cluster binding integral to membrane|Golgi apparatus|Golgi lumen|endoplasmic reticulum membrane|fungal-type vacuole|cis-Golgi network
YKL038W YKL038W RGT1 hom Verified 1.65783281792366 0.0486756076511298 no 354 0.0740418287026687 318 NA FT TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM NUCLEUS Glucose-responsive transcription factor; regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor; RGT1 has a paralog, EDS1, that arose from the whole genome duplication glucose transport|regulation of glucose import|negative regulation of transcription from RNA polymerase II promoter|glucose metabolic process|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription nucleus
YGL013C YGL013C PDR1 hom Verified 1.65737423985889 0.0487219180850822 no 355 0.150543550565496 618 NA FF|FT TRANSCRIPTION FROM RNA POL II NUCLEUS RSC COMPLEX Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication Unknown|positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YOR161C YOR161C PNS1 hom Verified 1.6559385640118 0.0488671304694405 no 356 0.0524538513203608 245 NA FT PLASMA MEMBRANE Protein of unknown function; has similarity to Torpedo californica tCTL1p, which is postulated to be a choline transporter, neither null mutation nor overexpression affects choline transport biological_process choline transmembrane transporter activity|molecular_function integral to membrane|plasma membrane|integral to plasma membrane
YDR382W YDR382W RPP2B hom Verified 1.65427312696599 0.0490360152728508 no 357 0.039042629742149 205 NA FT TRANSLATION RIBOSOME Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm translational elongation|cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YDR456W YDR456W NHX1 hom Verified 1.6525389556185 0.0492123653129605 no 358 0.0515853548460539 322 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS GOLGI APPARATUS Na+/H+ and K+/H+ exchanger, required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion sodium ion transmembrane transport|potassium ion transmembrane transport|cellular monovalent inorganic cation homeostasis|vacuolar acidification sodium:hydrogen antiporter activity|potassium:hydrogen antiporter activity trans-Golgi network|late endosome|fungal-type vacuole membrane|integral to membrane|early endosome
YNL241C YNL241C ZWF1 hom Verified 1.64948040963564 0.0495246266845129 no 359 0.0446518081699098 256 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS Glucose-6-phosphate dehydrogenase (G6PD); catalyzes the first step of the pentose phosphate pathway; involved in adapting to oxidatve stress; homolog of the human G6PD which is deficient in patients with hemolytic anemia; protein abundance increases in response to DNA replication stress NADPH regeneration|response to hydrogen peroxide|pentose-phosphate shunt, oxidative branch|carbon catabolite repression of transcription glucose-6-phosphate dehydrogenase activity cytoplasm
YHL002W YHL002W HSE1 hom Verified 1.64775193995208 0.0497017924380086 no 360 0.058717379144956 195 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes late endosome to vacuole transport|protein targeting to vacuole ubiquitin binding endosome|ESCRT-0 complex
YNL197C YNL197C WHI3 hom Verified 1.64145016727613 0.0503520016818599 no 361 0.0537723719938287 289 NA FT PROTEIN LOCALIZATION|CELL CYCLE RNA binding protein that sequesters CLN3 mRNA in cytoplasmic foci;; Tpk1 (PKA) mediated phosphorylation of Whi3 affects G1/S transition by modulating Cln3 transcription; cytoplasmic retention factor for Cdc28p and associated cyclins; regulates cell fate and dose-dependently regulates the critical cell size required for passage through Start; WHI3 has a paralog, WHI4, that arose from the whole genome duplication pseudohyphal growth|invasive growth in response to glucose limitation|regulation of cell size|cytoplasmic sequestering of protein RNA binding cytoplasm
YGR106C YGR106C VOA1 hom Verified 1.63864349887605 0.0506437637544558 no 362 0.101626558239896 418 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Endoplasmic reticulum protein that functions, together with other assembly factors, in assembly of the V0 sector of the vacuolar ATPase (V-ATPase); null mutation enhances the V-ATPase deficiency of a vma21 mutant impaired in ER retrieval protein complex assembly molecular_function fungal-type vacuole membrane|endoplasmic reticulum membrane
YML062C YML062C MFT1 hom Verified 1.63295107709721 0.0512396432169533 no 363 0.0619006910368242 313 NA FT TRANSCRIPTION FROM RNA POL II|RNA LOCALIZATION NUCLEUS Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance mRNA export from nucleus|DNA recombination|transcription elongation from RNA polymerase II promoter protein complex scaffold|nucleic acid binding THO complex part of transcription export complex|nucleoplasmic THO complex
YML030W YML030W RCF1 hom Verified 1.63239478911223 0.0512981730829479 no 364 0.0478380417191591 246 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Cytochrome c oxidase subunit; required for assembly of the Complex III-Complex IV supercomplex, and for assembly of Cox13p and Rcf2p into cytochrome c oxidase; similar to Rcf2p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; required for growth under hypoxic conditions; member of the hypoxia induced gene family; C. elegans and human orthologs are functional in yeast mitochondrial respiratory chain complex IV assembly|mitochondrial respiratory chain supercomplex assembly molecular_function mitochondrion|mitochondrial respiratory chain supercomplex|integral to mitochondrial inner membrane|mitochondrial respiratory chain complex IV
YPL257W_p YPL257W YPL257W hom Uncharacterized 1.63086640652308 0.0514592557589419 no 365 0.0586477894764673 267 NA FT CELL CYCLE Putative protein of unknown function; homozygous diploid deletion strain exhibits low budding index; physically interacts with Hsp82p; YPL257W is not an essential gene biological_process molecular_function integral to membrane
YMR167W YMR167W MLH1 hom Verified 1.63049877812332 0.0514980616187966 no 366 0.0348297396380457 180 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION|CHROMOSOME Protein required for mismatch repair in mitosis and meiosis as well as crossing over during meiosis; forms a complex with Pms1p and Msh2p-Msh3p during mismatch repair; human homolog is associated with hereditary non-polyposis colon cancer mismatch repair|meiotic mismatch repair|reciprocal meiotic recombination|meiotic heteroduplex formation double-stranded DNA binding|DNA insertion or deletion binding|loop DNA binding|single-stranded DNA binding|dinucleotide insertion or deletion binding|ATPase activity|ATP binding mitochondrion|nucleus|MutLalpha complex|MutLbeta complex|cytoplasm
YFR009W YFR009W GCN20 hom Verified 1.62895015569475 0.051661785567869 no 367 0.0923510671032193 448 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|NUCLEOTIDE METABOLISM RIBOSOME Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA regulation of translational elongation ATPase activity cytosol|cytosolic ribosome
YNR064C YNR064C YNR064C hom Verified 1.62544348409599 0.0520340484100695 no 368 0.0471216666188437 298 NA Epoxide hydrolase, member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides response to toxin epoxide hydrolase activity cellular_component
YLR171W_d YLR171W YLR171W hom Dubious 1.61978370977357 0.0526393734087895 no 369 0.0588627146628033 329 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YBL012C_d YBL012C YBL012C hom Dubious 1.61897781103731 0.0527260186923992 no 370 0.0526538068843875 287 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOL061W YOL061W PRS5 hom Verified 1.61529816202083 0.0531230707481583 no 371 0.0552803170040199 219 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; forms cytoplasmic foci upon DNA replication stress fungal-type cell wall organization|5-phosphoribose 1-diphosphate biosynthetic process ribose phosphate diphosphokinase activity cytoplasm
YML012C-A_d YML012C-A YML012C-A hom Dubious 1.60828816362331 0.0538860408839504 no 372 0.0650283926385304 346 NA FF Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SEL1 Unknown Unknown Unknown
YHR096C YHR096C HXT5 hom Verified 1.60399342368387 0.0543577510958974 no 373 0.0627215769432512 255 NA FT PLASMA MEMBRANE Hexose transporter with moderate affinity for glucose; induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs; HXT5 has a paralog, HXT3, that arose from the whole genome duplication glucose transport|hexose transport mannose transmembrane transporter activity|fructose transmembrane transporter activity|glucose transmembrane transporter activity integral to membrane|plasma membrane
YCL058C YCL058C FYV5 hom Verified 1.60279409930784 0.0544900600092298 no 374 0.0580995515236934 269 NA FT SIGNALING|ION HOMEOSTASIS|ION HOMEOSTASIS Protein involved in regulation of the mating pathway; binds with Matalpha2p to promoters of haploid-specific genes; required for survival upon exposure to K1 killer toxin; involved in ion homeostasis pheromone-dependent signal transduction involved in conjugation with cellular fusion|cellular ion homeostasis molecular_function integral to membrane
YMR116C YMR116C ASC1 hom Verified 1.60184429359426 0.0545950227643102 no 375 0.0588714854435613 316 NA FT SIGNALING|TRANSLATION RIBOSOME G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; regulates P-body formation induced by replication stress; represses Gcn4p in the absence of amino acid starvation negative regulation of translation|glucose mediated signaling pathway|G-protein coupled receptor signaling pathway|invasive growth in response to glucose limitation G-protein alpha-subunit binding|GDP-dissociation inhibitor activity|signal transducer activity cytosolic small ribosomal subunit|cytoplasm
YLR124W_d YLR124W YLR124W hom Dubious 1.59849632583126 0.0549662812282746 no 376 0.0571902565942144 252 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YCL061C YCL061C MRC1 hom Verified 1.59834773782119 0.0549828043780683 no 377 0.0725971161073452 352 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|GENE SILENCING NUCLEUS|CHROMOSOME S-phase checkpoint protein required for DNA replication; interacts with and stabilizes Pol2p at stalled replication forks during stress, where it forms a pausing complex with Tof1p and is phosphorylated by Mec1p; protects uncapped telomeres maintenance of DNA repeat elements|intra-S DNA damage checkpoint|DNA repair|DNA replication checkpoint|telomere maintenance|replication fork protection|DNA replication|mitotic sister chromatid cohesion|chromatin silencing at silent mating-type cassette|chromatin silencing at telomere molecular_function nuclear chromosome|replication fork protection complex|nucleus|nuclear replication fork
YHR123W YHR123W EPT1 hom Verified 1.59737743123227 0.0550908000553142 no 378 0.0374070104571856 183 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability; EPT1 has a paralog, CPT1, that arose from the whole genome duplication phosphatidylethanolamine biosynthetic process|phosphatidylcholine biosynthetic process ethanolaminephosphotransferase activity|diacylglycerol cholinephosphotransferase activity integral to membrane|Golgi apparatus
YDR225W YDR225W HTA1 hom Verified 1.59644349131151 0.0551949063169447 no 379 0.0598143438506071 330 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME RSC COMPLEX Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p DNA repair|chromatin assembly or disassembly|negative regulation of transcription from RNA polymerase II promoter DNA binding replication fork protection complex|nuclear nucleosome
YBR299W YBR299W MAL32 hom Verified 1.5957786443617 0.0552691114323353 no 380 0.0595034083527057 278 NA FT CARBOHYDRATE METABOLISM Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose sucrose catabolic process|maltose catabolic process sucrose alpha-glucosidase activity|alpha-glucosidase activity|maltose alpha-glucosidase activity plasma membrane
YNR072W YNR072W HXT17 hom Verified 1.59007969625814 0.0559084209850071 no 381 0.0496551345749865 259 NA FT PLASMA MEMBRANE Hexose transporter, up-regulated in media containing raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose hexose transport mannose transmembrane transporter activity|glucose transmembrane transporter activity|fructose transmembrane transporter activity integral to membrane|plasma membrane
YPL015C YPL015C HST2 hom Verified 1.58263649706484 0.0567521699340441 no 382 0.0738360837235923 273 NA FT GENE SILENCING NUCLEUS Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro; contains a nuclear export signal (NES); function regulated by its nuclear export negative regulation of chromatin silencing at telomere|chronological cell aging|chromatin silencing at rDNA|negative regulation of mitotic recombination NAD-dependent histone deacetylase activity cytoplasm
YIL053W YIL053W RHR2 hom Verified 1.57907728729126 0.0571591653110985 no 383 0.0792328794002006 376 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Constitutively expressed glycerol-1-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and osmotic stress; RHR2 has a paralog, HOR2, that arose from the whole genome duplication glycerol biosynthetic process|response to osmotic stress glycerol-1-phosphatase activity nucleus|cytoplasm
YML113W YML113W DAT1 hom Verified 1.57856002411993 0.0572185050425996 no 384 0.0465811077843135 204 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS DNA binding protein that recognizes oligo(dA).oligo(dT) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; not essential for viability negative regulation of transcription from RNA polymerase II promoter AT DNA binding nucleus
YER040W YER040W GLN3 hom Verified 1.57755540789748 0.0573338917697332 no 385 0.0549985392814523 299 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS NUCLEUS Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR), localization and activity regulated by quality of nitrogen source nitrogen catabolite activation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity cytosol|nucleus
YJL121C YJL121C RPE1 hom Verified 1.57574925138227 0.0575418010389222 no 386 0.0769901433456496 330 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress pentose-phosphate shunt ribulose-phosphate 3-epimerase activity cytosol
YNL296W_d YNL296W YNL296W hom Dubious 1.57529254880238 0.0575944665496295 no 387 0.0737706764716787 322 NA Dubious open reading frame unlikely to encode a functional protein; deletion adversely affects sporulation; deletion mutant exhibits synthetic phenotype under expression of mutant huntingtin fragment, but gene does not have human ortholog Unknown Unknown Unknown
YNL069C YNL069C RPL16B hom Verified 1.57281945410687 0.057880314850639 no 388 0.079002322821143 333 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L16B; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16B has a paralog, RPL16A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YGL125W YGL125W MET13 hom Verified 1.57143275448766 0.0580410813775269 no 389 0.0642059443180759 208 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION Major isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway methionine biosynthetic process methylenetetrahydrofolate reductase (NADPH) activity mitochondrion
YGL211W YGL211W NCS6 hom Verified 1.56892469125487 0.0583327438897799 no 390 0.0630059761814433 269 NA FT RNA PROCESSING MITOCHONDRION Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae tRNA wobble position uridine thiolation|protein urmylation|tRNA wobble uridine modification tRNA binding cytosol|mitochondrion
YIR003W YIR003W AIM21 hom Verified 1.5666351679678 0.0585999963444201 no 391 0.0473743251834261 216 NA FT SITE OF POLARIZED GROWTH|CYTOSKELETON Protein of unknown function involved in mitochondrial migration along actin filament; may interact with ribosomes; GFP-fusion protein colocalizes with Sac1p to the actin cytoskeleton mitochondrion migration along actin filament molecular_function ribosome|mating projection tip|actin cytoskeleton
YFR033C YFR033C QCR6 hom Verified 1.56571697840097 0.0587074448420382 no 392 0.056246525324983 294 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Subunit 6 of the ubiquinol cytochrome-c reductase complex; the complex, also known as the cytochrome bc(1) complex or Complex III, is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1; may be loosely associated with the complex since it is easily released into the intermembrane space mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration ubiquinol-cytochrome-c reductase activity mitochondrion|integral to membrane|mitochondrial respiratory chain complex III
YGR161C_p YGR161C RTS3 hom Uncharacterized 1.5637777361481 0.0589348872676572 no 393 0.0570470394566607 247 NA FT NUCLEUS Putative component of the protein phosphatase type 2A complex biological_process molecular_function nucleus|cytoplasm
YLR394W YLR394W CST9 hom Verified 1.56344384178122 0.0589741174653667 no 394 0.0544662729728208 218 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME SUMO E3 ligase; required for synaptonemal complex formation; localizes to synapsis initiation sites on meiotic chromosomes; potential Cdc28p substrate synaptonemal complex assembly|protein sumoylation|synapsis|reciprocal meiotic recombination SUMO ligase activity condensed nuclear chromosome|nuclear chromosome
YJL062W YJL062W LAS21 hom Verified 1.56049668637999 0.0593212762084728 no 395 0.0625819616052036 343 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure; mutations affect cell wall integrity GPI anchor biosynthetic process mannose-ethanolamine phosphotransferase activity|transferase activity integral to endoplasmic reticulum membrane|integral to membrane|integral to plasma membrane
YIL001W_p YIL001W YIL001W hom Uncharacterized 1.55590586938577 0.0598652387522779 no 396 0.0729430264484283 277 NA Putative protein of unknown function; contains a BTB/POZ domain which generally function in protein interactions; deletion slightly improved competitive fitness in rich media; GFP-tagged protein is localized to the cytoplasm biological_process molecular_function cytoplasm
YMR250W YMR250W GAD1 hom Verified 1.55462184623603 0.0600180788472612 no 397 0.0651886210067244 295 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|RESPONSE TO OXIDATIVE STRESS Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress cellular response to oxidative stress|glutamate catabolic process calmodulin binding|glutamate decarboxylase activity cytoplasm
YCR092C YCR092C MSH3 hom Verified 1.5536691789403 0.0601316742587124 no 398 0.0688588794333607 353 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Mismatch repair protein, forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability mismatch repair|mitotic recombination|meiotic mismatch repair|removal of nonhomologous ends|DNA recombination DNA insertion or deletion binding|mismatched DNA binding|double-strand/single-strand DNA junction binding|loop DNA binding|Y-form DNA binding MutSbeta complex|nucleus|cytoplasm
YMR153W YMR153W NUP53 hom Verified 1.55249803332266 0.0602715514612213 no 399 0.0520154418448121 262 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE FG-nucleoporin component of central core of nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes directly to nucleocytoplasmic transport; involved in regulation of transcription and mitosis; induces membrane tubulation, which may contribute to nuclear pore assembly; NUP53 has a paralog, ASM4, that arose from the whole genome duplication positive regulation of transcription, DNA-dependent|NLS-bearing substrate import into nucleus|regulation of protein desumoylation|nuclear pore organization|protein import into nucleus|regulation of mitosis|mitotic cell cycle spindle assembly checkpoint nucleocytoplasmic transporter activity|phospholipid binding|single-stranded DNA binding nuclear pore central transport channel|nuclear pore nuclear basket|integral to membrane|nuclear pore
YJL108C YJL108C PRM10 hom Verified 1.54881207801941 0.0607134506264673 no 400 0.0712617594084452 277 NA Pheromone-regulated protein, proposed to be involved in mating; predicted to have 5 transmembrane segments; induced by treatment with 8-methoxypsoralen and UVA irradiation biological_process molecular_function integral to membrane
YGL033W YGL033W HOP2 hom Verified 1.54675198660414 0.0609615309901946 no 401 0.0997407968699927 418 NA FF|FT CELL CYCLE NUCLEUS|CHROMOSOME Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair synapsis|reciprocal meiotic recombination protein binding|double-stranded DNA binding condensed nuclear chromosome
YNR057C YNR057C BIO4 hom Verified 1.54438650272456 0.0612473639334882 no 402 0.0737110115407129 320 NA FT KETONE METABOLISM|COFACTOR METABOLISM Dethiobiotin synthetase, catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; expression appears to be repressed at low iron levels biotin biosynthetic process dethiobiotin synthase activity cytoplasm
YIR014W_p YIR014W YIR014W hom Uncharacterized 1.54305863742013 0.0614082746699377 no 403 0.0499739801640815 204 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; YIR014W is a non-essential gene biological_process molecular_function fungal-type vacuole
YJL185C YJL185C ATG36 hom Verified 1.54151380208765 0.0615958932016481 no 404 0.0537376095827497 241 NA Pex3p interacting protein, required for pexophagy; interacts with Atg8p and Atg11p; mRNA is weakly cell cycle regulated, peaking in G2 phase; YJL185C is a non-essential gene peroxisome degradation molecular_function peroxisome
YER124C YER124C DSE1 hom Verified 1.54052700171118 0.0617159731010061 no 405 0.0735699876403266 335 NA FT CELL CYCLE|SIGNALING|CELL WALL ORG/BIOGENESIS|CELL DIVISION SITE OF POLARIZED GROWTH Daughter cell-specific protein, may regulate cross-talk between the mating and filamentation pathways; deletion affects cell separation after division and sensitivity to alpha-factor and drugs affecting the cell wall; relocalizes from bud neck to cytoplasm upon DNA replication stress cytokinesis, completion of separation|regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion|invasive growth in response to glucose limitation molecular_function cellular bud neck
YGL021W YGL021W ALK1 hom Verified 1.53710070977184 0.0621343245987027 no 406 0.0627522874179586 265 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; ALK1 has a paralog, ALK2, that arose from the whole genome duplication; similar to mammalian haspins mitosis|protein phosphorylation protein serine/threonine kinase activity|protein kinase activity cellular_component
YBL088C YBL088C TEL1 hom Verified 1.53487835449527 0.0624068556815158 no 407 0.0584934570198839 243 NA FT CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION NUCLEUS|MITOCHONDRION|CHROMOSOME Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; regulates P-body formation induced by replication stress; homolog of human ataxia-telangiectasia mutated (ATM) gene, the gene responsible for ataxia telangiectasia (AT) (OMIM 607585) double-strand break repair|histone phosphorylation|telomere maintenance|response to DNA damage stimulus|phosphorylation|DNA damage induced protein phosphorylation protein kinase activity|telomeric DNA binding mitochondrion|nucleus
YML115C YML115C VAN1 hom Verified 1.5345535119108 0.0624467696234367 no 408 0.1039142913694 399 NA FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Component of the mannan polymerase I, which contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant protein N-linked glycosylation alpha-1,6-mannosyltransferase activity alpha-1,6-mannosyltransferase complex
YOR036W YOR036W PEP12 hom Verified 1.53178420813519 0.0627878471304486 no 409 0.100646000785362 458 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT GOLGI APPARATUS Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin Golgi to vacuole transport|vacuole inheritance SNAP receptor activity endosome|Golgi apparatus
YMR078C YMR078C CTF18 hom Verified 1.53084569689056 0.0629037663553743 no 410 0.0506602295563738 253 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS|MITOCHONDRION|CHROMOSOME Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint maintenance of DNA trinucleotide repeats|double-strand break repair via homologous recombination|DNA replication initiation|mitotic sister chromatid cohesion molecular_function mitochondrion|nuclear replication fork|Ctf18 RFC-like complex
YMR306W YMR306W FKS3 hom Verified 1.53026341917316 0.0629757695415006 no 411 0.0738850287005581 347 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM MITOCHONDRION|PLASMA MEMBRANE Protein involved in spore wall assembly, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies ascospore wall assembly 1,3-beta-D-glucan synthase activity mitochondrion|integral to membrane
YNL318C YNL318C HXT14 hom Verified 1.52738243206911 0.063332971173978 no 412 0.0506508972772055 214 NA FT MITOCHONDRION|PLASMA MEMBRANE Protein with similarity to hexose transporter family members, expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies hexose transport galactose transmembrane transporter activity mitochondrion|integral to membrane|plasma membrane
YOL122C YOL122C SMF1 hom Verified 1.52676040144576 0.0634103008088981 no 413 0.0543194546750891 277 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Divalent metal ion transporter with a broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins copper ion transport|cellular copper ion homeostasis|manganese ion transport|cadmium ion transport|cellular manganese ion homeostasis|cellular cadmium ion homeostasis|iron ion transport solute:hydrogen symporter activity|inorganic cation transmembrane transporter activity integral to membrane|plasma membrane
YJL146W YJL146W IDS2 hom Verified 1.52315027697694 0.0638605563645082 no 414 0.0546901253448657 221 NA FT CELL CYCLE NUCLEUS Protein involved in modulation of Ime2p activity during meiosis, appears to act indirectly to promote Ime2p-mediated late meiotic functions; found in growing cells and degraded during sporulation meiosis molecular_function nucleus|cytoplasm
YKL143W YKL143W LTV1 hom Verified 1.520300255454 0.0642177649357276 no 415 0.0574730252555308 297 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RESPONSE TO OXIDATIVE STRESS NUCLEUS Component of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; required for ribosomal small subunit export from nucleus; required for growth at low temperature ribosomal small subunit biogenesis|cellular response to oxidative stress|response to osmotic stress|ribosomal small subunit export from nucleus molecular_function preribosome, small subunit precursor|EGO complex|nucleus|late endosome membrane|cytoplasm
YBR195C YBR195C MSI1 hom Verified 1.51935177788959 0.0643369865529533 no 416 0.0515134939429746 220 NA FT CHROMATIN ORGANIZATION NUCLEUS Subunit of chromatin assembly factor I (CAF-1); chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription; Msi1p localizes to both nucleus and cytoplasm and has an independent role as a negative regulator of the RAS/cAMP pathway via sequestration of Npr1p kinase DNA replication-dependent nucleosome assembly histone binding nucleus|CAF-1 complex|cytoplasm
YJL135W_d YJL135W YJL135W hom Dubious 1.51748936660121 0.0645715880827561 no 417 0.0466012093131392 208 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3 Unknown Unknown Unknown
YKR056W YKR056W TRM2 hom Verified 1.516180683601 0.0647368355050988 no 418 0.0584233615259545 307 NA FT RNA PROCESSING|RESPONSE TO DNA DAMAGE tRNA methyltransferase, 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation; endo-exonuclease with a role in DNA repair double-strand break repair|DNA repair|tRNA modification tRNA (m5U54) methyltransferase activity|double-stranded DNA specific 5'-3' exodeoxyribonuclease activity|single-stranded DNA specific endodeoxyribonuclease activity cellular_component
YBR108W YBR108W AIM3 hom Verified 1.51158635386341 0.0653195626776437 no 419 0.0572766630473307 265 NA FT CYTOSKELETON ORGANIZATION CYTOSKELETON Protein interacting with Rvs167p; null mutant is viable and displays elevated frequency of mitochondrial genome loss actin cortical patch assembly molecular_function membrane raft|actin cortical patch
YGR087C YGR087C PDC6 hom Verified 1.50949495103421 0.0655861722997408 no 420 0.0605940530449208 264 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation L-phenylalanine catabolic process|ethanol metabolic process|tryptophan catabolic process|aromatic amino acid family catabolic process to alcohol via Ehrlich pathway pyruvate decarboxylase activity cytoplasm
YDL200C YDL200C MGT1 hom Verified 1.50665832109036 0.0659491300042458 no 421 0.0846457787712514 339 NA FT RESPONSE TO DNA DAMAGE NUCLEUS DNA repair methyltransferase (6-O-methylguanine-DNA methylase) involved in protection against DNA alkylation damage DNA dealkylation involved in DNA repair methylated-DNA-[protein]-cysteine S-methyltransferase activity nucleus
YOL093W YOL093W TRM10 hom Verified 1.50588414595187 0.0660484585608821 no 422 0.0813292508530136 343 NA FT RNA PROCESSING NUCLEUS tRNA methyltransferase; methylates the N-1 position of guanosine in tRNAs; protein abundance increases in response to DNA replication stress tRNA methylation tRNA (guanine) methyltransferase activity nucleus|cytoplasm
YKL206C YKL206C ADD66 hom Verified 1.50338828160561 0.0663694733218865 no 423 0.0611533887252179 263 NA FT PROTEIN COMPLEX ORG/BIOGENESIS Protein involved in 20S proteasome assembly; forms a heterodimer with Pba1p that binds to proteasome precursors; similar to human PAC2 constituent of the PAC1-PAC2 complex involved in proteasome assembly proteasome assembly molecular_function cytosol|cytoplasm
YHR103W YHR103W SBE22 hom Verified 1.49614274556637 0.0673082303982536 no 424 0.0700563630704344 296 NA FT PROTEIN LOCALIZATION|CELL WALL ORG/BIOGENESIS GOLGI APPARATUS Protein involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; involved in bud growth fungal-type cell wall organization molecular_function cytoplasm
YPL181W YPL181W CTI6 hom Verified 1.49589755563665 0.0673401767011219 no 425 0.0812415539776771 343 NA FT CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain negative regulation of chromatin silencing at silent mating-type cassette|positive regulation of transcription, DNA-dependent|regulation of DNA-dependent DNA replication initiation|negative regulation of chromatin silencing at telomere|negative regulation of chromatin silencing at rDNA methylated histone residue binding|transcription factor binding Rpd3L-Expanded complex|nucleus|Rpd3L complex
YFR023W YFR023W PES4 hom Verified 1.49583520673368 0.0673483021374533 no 426 0.0764093237379787 274 NA FT NUCLEUS Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation; PES4 has a paralog, MIP6, that arose from the whole genome duplication biological_process molecular_function cellular_component
YOL023W YOL023W IFM1 hom Verified 1.49575942924201 0.0673581786351394 no 427 0.089281646572971 403 NA FT TRANSLATION|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial translation initiation factor 2 translational initiation|mitochondrial translational initiation|mitochondrial translation tRNA binding|GTPase activity|translation initiation factor activity mitochondrion
YIL007C YIL007C NAS2 hom Verified 1.49282975925404 0.0677408776445824 no 428 0.0500303926676293 264 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS NUCLEUS Proteasome-interacting protein; involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); similar to mammalian proteasomal modulator subunit; non-essential gene; interacts with Rpn4p; protein abundance increases in response to DNA replication stress proteasome regulatory particle assembly|ubiquitin-dependent protein catabolic process molecular_function cytosol|nucleus|cytoplasm
YLR434C_d YLR434C YLR434C hom Dubious 1.49147611489563 0.0679182687846966 no 429 0.0824441850136075 303 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TSR2/YLR435W Unknown Unknown Unknown
YAL022C YAL022C FUN26 hom Verified 1.49118215957745 0.0679568381358776 no 430 0.0680229908328467 292 NA Vacuolar membrane transporter with broad nucleoside selectivity; may regulate balance of nicotinamide riboside (NmR) levels between cytosol and vacuole, contributing to salvage of NmR for use in cytosolic NAD+ synthesis nucleoside transport|nicotinamide riboside transport|transmembrane transport nicotinamide riboside transporter activity|nucleoside transmembrane transporter activity fungal-type vacuole membrane|integral to membrane|intracellular|membrane
YGR129W YGR129W SYF2 hom Verified 1.48967294966923 0.0681551252374116 no 431 0.0864477382652978 366 NA FT RNA PROCESSING NUCLEUS Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; isy1 syf2 cells have defective spindles activiating cell cycle arrest mRNA splicing, via spliceosome first spliceosomal transesterification activity|second spliceosomal transesterification activity U2-type post-mRNA release spliceosomal complex|Prp19 complex|U2-type prespliceosome|U2-type catalytic step 2 spliceosome|U2-type catalytic step 1 spliceosome
YFR032C_p YFR032C RRT5 hom Uncharacterized 1.486147328599 0.0686200779440571 no 432 0.0646357805020097 326 NA Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; expressed at high levels during sporulation biological_process molecular_function cellular_component
YDR129C YDR129C SAC6 hom Verified 1.48610256933071 0.0686259964043002 no 433 0.194335253051695 724 NA FF|FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton; relocalizes from plasma membrane to cytoplasm upon DNA replication stress bipolar cellular bud site selection|actin filament organization|endocytosis|response to osmotic stress actin filament binding|protein binding, bridging actin filament bundle|mating projection tip|actin cortical patch
YAR027W YAR027W UIP3 hom Verified 1.48585159582491 0.0686591895999281 no 434 0.0654615116404838 230 NA FT ENDOMEMBRANE SYSTEM|NUCLEUS|PLASMA MEMBRANE Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family biological_process molecular_function nuclear envelope
YIL044C YIL044C AGE2 hom Verified 1.48389236478178 0.0689187388858015 no 435 0.0714926176212647 319 NA FT VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM GOLGI APPARATUS ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in Trans-Golgi-Network (TGN) transport; contains C2C2H2 cysteine/histidine motif ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport ARF GTPase activator activity clathrin-coated vesicle
YHL003C YHL003C LAG1 hom Verified 1.48221887256037 0.0691410332559689 no 436 0.0470478644533554 234 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress replicative cell aging|ceramide biosynthetic process sphingosine N-acyltransferase activity integral to membrane|endoplasmic reticulum
YMR075W YMR075W RCO1 hom Verified 1.47887875648193 0.0695863609775943 no 437 0.0732617969489207 317 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p regulation of DNA-dependent DNA replication initiation|negative regulation of antisense RNA transcription|transcription elongation from RNA polymerase II promoter|histone deacetylation molecular_function Rpd3S complex|histone deacetylase complex|nucleus|Rpd3L complex
YJL059W YJL059W YHC3 hom Verified 1.47741869448731 0.0697817190064661 no 438 0.0587870073206122 277 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT Vacuolar membrane protein involved in the ATP-dependent transport of arginine into the vacuole and possibly in balancing ion homeostasis; homolog of human CLN3 involved in Batten disease (juvenile onset neuronal ceroid lipofuscinosis) basic amino acid transport|regulation of intracellular pH|arginine transport molecular_function integral to membrane|fungal-type vacuole
YPR001W YPR001W CIT3 hom Verified 1.47586672707665 0.0699898366346239 no 439 0.0850048921584045 344 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate propionate catabolic process, 2-methylcitrate cycle|propionate metabolic process|tricarboxylic acid cycle 2-methylcitrate synthase activity|citrate (Si)-synthase activity mitochondrion
YBR095C YBR095C RXT2 hom Verified 1.47404679119426 0.0702344966264871 no 440 0.100355436201088 406 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Subunit of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth conjugation with cellular fusion|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of transcription from RNA polymerase II promoter|negative regulation of chromatin silencing at telomere|negative regulation of chromatin silencing at rDNA|invasive growth in response to glucose limitation histone deacetylase activity Rpd3L-Expanded complex|nucleus|Rpd3L complex
YPL259C YPL259C APM1 hom Verified 1.47297013632871 0.0703795442452362 no 441 0.0975241198790742 410 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Mu1-like medium subunit of the clathrin-associated protein complex (AP-1); binds clathrin; involved in clathrin-dependent Golgi protein sorting Golgi to vacuole transport|vesicle-mediated transport clathrin binding AP-1 adaptor complex
YNL259C YNL259C ATX1 hom Verified 1.47290218998312 0.0703887057400521 no 442 0.0771573750382106 337 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake copper ion transport|cellular response to oxidative stress|cellular iron ion homeostasis copper chaperone activity cytosol
YJL154C YJL154C VPS35 hom Verified 1.47178571231446 0.0705393765276471 no 443 0.107412253050564 441 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p protein retention in Golgi apparatus|retrograde transport, endosome to Golgi protein transporter activity endosome|retromer complex, inner shell|retromer complex
YER088C YER088C DOT6 hom Verified 1.47085845384426 0.0706647001691795 no 444 0.0738755597858228 378 NA FT TRANSCRIPTION FROM RNA POL II|GENE SILENCING NUCLEUS|CHROMOSOME Protein involved in rRNA and ribosome biogenesis; binds polymerase A and C motif; subunit of the RPD3L histone deacetylase complex; has chromatin specific SANT domain; involved in telomeric gene silencing and filamentation; DOT6 has a paralog, TOD6, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress chromatin silencing at rDNA|filamentous growth|regulation of transcription from RNA polymerase II promoter|unidimensional cell growth|chromatin silencing at telomere sequence-specific DNA binding Rpd3L-Expanded complex|nucleus|Rpd3L complex|cytoplasm
YPL195W YPL195W APL5 hom Verified 1.4703694211841 0.0707308642730791 no 445 0.0965754205861838 395 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Delta adaptin-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function vesicle-mediated transport|Golgi to vacuole transport protein binding AP-3 adaptor complex
YHR139C YHR139C SPS100 hom Verified 1.47029710727633 0.070740652085544 no 446 0.080452573921586 342 NA FT KETONE METABOLISM|CELL CYCLE|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall; expression also induced in cells treated with the mycotoxin patulin ascospore wall assembly molecular_function ascospore wall
YAL055W YAL055W PEX22 hom Verified 1.46644769621853 0.071263180241337 no 447 0.084309594488373 306 NA FT PROTEIN LOCALIZATION|SIGNALING|PEROXISOME ORGANIZATION Putative peroxisomal membrane protein required for import of peroxisomal proteins, functionally complements a Pichia pastoris pex22 mutation protein import into peroxisome matrix, receptor recycling|protein targeting to peroxisome protein anchor integral to peroxisomal membrane
YDR034C YDR034C LYS14 hom Verified 1.46560804388792 0.0713775492977782 no 448 0.0711686803883388 283 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer Unknown|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YLR309C YLR309C IMH1 hom Verified 1.46407155395255 0.0715871993226886 no 449 0.0586303069114544 254 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Protein involved in vesicular transport, mediates transport between an endosomal compartment and the Golgi, contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi Golgi to plasma membrane protein transport|vesicle-mediated transport molecular_function cytosol|Golgi apparatus
YKR014C YKR014C YPT52 hom Verified 1.46375744246087 0.071630117121663 no 450 0.079013036221614 345 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|VACUOLAR TRANSPORT ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Rab family GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; protein abundance increases in response to DNA replication stress endocytosis|protein targeting to vacuole GTPase activity late endosome
YHR193C YHR193C EGD2 hom Verified 1.45887558089677 0.0722996776135152 no 451 0.0709560403977852 305 NA FT PROTEIN LOCALIZATION NUCLEUS Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes 'de novo' cotranslational protein folding unfolded protein binding|phosphatidic acid binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4-phosphate binding nascent polypeptide-associated complex
YDR360W_d YDR360W OPI7 hom Dubious 1.45800023882392 0.0724202385937156 no 452 0.0744862612922632 321 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene VID21/YDR359C. Unknown Unknown Unknown
YKL025C YKL025C PAN3 hom Verified 1.45656242779198 0.0726186026956587 no 453 0.0957723704702332 378 NA FT RNA PROCESSING|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes DNA repair|mRNA 3'-end processing|postreplication repair poly(A)-specific ribonuclease activity PAN complex|cytoplasm
YHR086W YHR086W NAM8 hom Verified 1.45471463727703 0.0728741393205543 no 454 0.0700176996242209 281 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING NUCLEUS|MITOCHONDRION RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of REC107 pre-mRNA; Nam8p regulon embraces the meiotic pre-mRNAs of REC107, HFM1, AMA1 SPO22 and PCH2; the putative RNA binding domains RRM2 and RRM3 are required for Nam8p meiotic function mRNA splicing, via spliceosome|positive regulation of mRNA splicing, via spliceosome|mRNA splice site selection mRNA binding|RNA binding commitment complex|U1 snRNP|U2-type prespliceosome
YGL132W_d YGL132W YGL132W hom Dubious 1.45459602568338 0.0728905659643254 no 455 0.0528719070088669 242 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SNT2/YGL131C Unknown Unknown Unknown
YDR541C_p YDR541C YDR541C hom Uncharacterized 1.45424917181717 0.0729386183834867 no 456 0.0793663013072846 344 NA FT OXIDATION-REDUCTION PROCESS Putative dihydrokaempferol 4-reductase biological_process carbonyl reductase (NADPH) activity cellular_component
YML058W YML058W SML1 hom Verified 1.4520642530535 0.0732418701582283 no 457 0.040923339959621 184 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION NUCLEUS Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase mitochondrion organization|response to DNA damage stimulus enzyme inhibitor activity nucleus|cytoplasm
YDR466W YDR466W PKH3 hom Verified 1.45103099720864 0.0733856145078855 no 458 0.128394568756465 459 NA FF|FT SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant MAPK cascade involved in cell wall biogenesis|protein phosphorylation protein kinase activity cellular_component
YER129W YER129W SAK1 hom Verified 1.44692988370185 0.0739582812134393 no 459 0.0864489171659275 349 NA FT CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION Upstream serine/threonine kinase for the SNF1 complex; partially redundant with Elm1p and Tos3p; members of this family have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome protein phosphorylation|glucose metabolic process|DNA-dependent DNA replication protein serine/threonine kinase activity|protein kinase activity cytoplasm
YOR219C YOR219C STE13 hom Verified 1.44597052101143 0.0740927351437234 no 460 0.0780940423782954 308 NA FT PROTEOLYSIS GOLGI APPARATUS Dipeptidyl aminopeptidase, Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences, required for maturation of alpha factor, transcription is induced by a-factor peptide pheromone maturation aminopeptidase activity trans-Golgi network
YER031C YER031C YPT31 hom Verified 1.44543137103734 0.0741683785022746 no 461 0.125019553560708 492 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING ENDOMEMBRANE SYSTEM|MITOCHONDRION|GOLGI APPARATUS Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication early endosome to Golgi transport|vesicle-mediated transport|exocytosis GTPase activity mitochondrial outer membrane|endosome|Golgi apparatus
YIL161W_p YIL161W YIL161W hom Uncharacterized 1.44196733852419 0.0746557939091695 no 462 0.0564343221272162 269 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; mRNA is enriched in Scp160p-associated mRNPs; YIL161W is a non-essential gene biological_process molecular_function cytoplasm
YMR007W_d YMR007W YMR007W hom Dubious 1.43878551551342 0.0751056507405782 no 463 0.0457264663870329 215 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YCR071C YCR071C IMG2 hom Verified 1.43758934980963 0.0752753022617957 no 464 0.0886261649146485 361 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YNL009W YNL009W IDP3 hom Verified 1.43696472362271 0.0753640086772159 no 465 0.072582981498796 281 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Peroxisomal NADP-dependent isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acids; IDP3 has a paralog, IDP2, that arose from the whole genome duplication NADPH regeneration|fatty acid beta-oxidation|isocitrate metabolic process isocitrate dehydrogenase (NADP+) activity mitochondrion|peroxisome|cytoplasm
YMR315W YMR315W YMR315W hom Verified 1.4327737781249 0.0759612486525788 no 466 0.079202648500589 330 NA FT OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM NUCLEUS Protein with NADP(H) oxidoreductase activity; transcription is regulated by Stb5p in response to NADPH depletion induced by diamide; promoter contains a putative Stb5p binding site; protein abundance increases in response to DNA replication stress NADPH regeneration oxidoreductase activity nucleus|cytoplasm
YOR003W YOR003W YSP3 hom Verified 1.43173635901192 0.0761096433367132 no 467 0.0613894136708813 296 NA FT PROTEOLYSIS Putative precursor to the subtilisin-like protease III protein catabolic process peptidase activity cellular_component
YNR067C YNR067C DSE4 hom Verified 1.42917455648569 0.0764770343624561 no 468 0.0616453517883548 274 NA FT CELL WALL ORG/BIOGENESIS|CELL DIVISION Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother cytokinesis, completion of separation glucan endo-1,3-beta-D-glucosidase activity fungal-type cell wall|extracellular region|cell septum
YGL126W YGL126W SCS3 hom Verified 1.42914783188582 0.0764808740657336 no 469 0.0840439532028464 331 NA FT LIPID METABOLISM ENDOPLASMIC RETICULUM Protein required for inositol prototrophy; required for normal ER membrane biosynthesis; ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; disputed role in the synthesis of inositol phospholipids from inositol phospholipid metabolic process molecular_function integral to membrane|endoplasmic reticulum
YOL037C_d YOL037C YOL037C hom Dubious 1.42371940225325 0.0772638574493126 no 470 0.0851705254240893 342 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOL036W Unknown Unknown Unknown
YJR107W_p YJR107W YJR107W hom Uncharacterized 1.42213143111965 0.0774940498922598 no 471 0.0707147584513262 268 NA FT LIPID METABOLISM Putative lipase biological_process lipase activity cellular_component
YDL049C YDL049C KNH1 hom Verified 1.42209756469455 0.0774989648382157 no 472 0.0680019555603868 236 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance (1->6)-beta-D-glucan biosynthetic process molecular_function fungal-type cell wall|extracellular region
YPR014C_d YPR014C YPR014C hom Dubious 1.42174898784603 0.0775495666452763 no 473 0.0764524791785396 331 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR014C is not an essential gene Unknown Unknown Unknown
YGR181W YGR181W TIM13 hom Verified 1.41811189341951 0.0780790497233369 no 474 0.0496836409604748 245 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial intermembrane space protein, forms a complex with Tim8p that delivers a subset of hydrophobic proteins to the TIM22 complex for insertion into the inner membrane protein import into mitochondrial inner membrane protein transporter activity mitochondrion|integral to membrane|mitochondrial intermembrane space protein transporter complex|mitochondrial intermembrane space
YGR204C-A_p YGR204C-A YGR204C-A hom Uncharacterized 1.41725573485422 0.0782040859361695 no 475 0.0646050295284639 291 NA Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YDR229W YDR229W IVY1 hom Verified 1.41674861004788 0.0782782196968954 no 476 0.0841138295660028 341 NA FT MEMBRANE ORGANIZATION Phospholipid-binding protein that interacts with both Ypt7p and Vps33p, may partially counteract the action of Vps33p and vice versa, localizes to the rim of the vacuole as cells approach stationary phase vacuole fusion, non-autophagic phospholipid binding fungal-type vacuole membrane
YLR375W YLR375W STP3 hom Verified 1.41664783535939 0.078292957734708 no 477 0.0922662218762871 349 NA FT NUCLEUS Zinc-finger protein of unknown function, possibly involved in pre-tRNA splicing and in uptake of branched-chain amino acids biological_process sequence-specific DNA binding nucleus
YER055C YER055C HIS1 hom Verified 1.4160098006278 0.0783863175065025 no 478 0.0794828037421587 316 NA FT KETONE METABOLISM|AMINO ACID METABOLISM ATP phosphoribosyltransferase, a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control histidine biosynthetic process ATP phosphoribosyltransferase activity cellular_component
YIL076W YIL076W SEC28 hom Verified 1.41560629790028 0.0784454031812387 no 479 0.0739906165185654 329 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth; protein abundance increases in response to DNA replication stress late endosome to vacuole transport via multivesicular body sorting pathway|ER to Golgi vesicle-mediated transport|vesicle coating molecular_function endosome|COPI vesicle coat
YML063W YML063W RPS1B hom Verified 1.41397756047721 0.0786842455722676 no 480 0.0926703053890023 368 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal protein 10 (rp10) of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1B has a paralog, RPS1A, that arose from the whole genome duplication cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit|90S preribosome
YLR150W YLR150W STM1 hom Verified 1.4138507629716 0.0787028625921374 no 481 0.0855536284628935 321 NA FT SIGNALING|TRANSLATION NUCLEUS RIBOSOME Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery translational elongation|TOR signaling cascade|regulation of translational initiation in response to stress|telomere maintenance|anti-apoptosis triplex DNA binding|DNA binding|telomeric DNA binding cytosolic ribosome|polysome|cytoplasm
YKL056C YKL056C TMA19 hom Verified 1.4135304386214 0.0787499090223288 no 482 0.0810891789345293 348 NA FT TRANSLATION|RESPONSE TO OXIDATIVE STRESS MITOCHONDRION|CYTOSKELETON Protein that associates with ribosomes; homolog of translationally controlled tumor protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and relocates to the mitochondrial outer surface upon oxidative stress cytoplasmic translation|cellular response to oxidative stress molecular_function cytosol|mitochondrion|ribosome|cytoplasm
YJL153C YJL153C INO1 hom Verified 1.41349080582246 0.0787557314212277 no 483 0.088572710690279 320 NA FT LIPID METABOLISM|CARBOHYDRATE METABOLISM Inositol-3-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element inositol biosynthetic process inositol-3-phosphate synthase activity cytoplasm
YMR068W YMR068W AVO2 hom Verified 1.41234593004795 0.0789240643572292 no 484 0.0835235816081058 325 NA FT SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION PLASMA MEMBRANE Component of a complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth fungal-type cell wall organization|TOR signaling cascade|regulation of cell growth|establishment or maintenance of actin cytoskeleton polarity molecular_function TORC2 complex|cytoplasm
YDR315C YDR315C IPK1 hom Verified 1.41141955140781 0.0790604706822211 no 485 0.123087367139515 408 NA FT NUCLEUS Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable nuclear-transcribed mRNA catabolic process, non-stop decay|inositol phosphate biosynthetic process inositol pentakisphosphate 2-kinase activity nucleus
YBR288C YBR288C APM3 hom Verified 1.41140114392289 0.0790631829341309 no 486 0.10066656059007 416 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway Golgi to vacuole transport|vesicle-mediated transport molecular_function AP-3 adaptor complex
YOL058W YOL058W ARG1 hom Verified 1.41036826635459 0.0792154852745284 no 487 0.0982072505053931 371 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Arginosuccinate synthetase, catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate argininosuccinate metabolic process|arginine biosynthetic process|citrulline metabolic process argininosuccinate synthase activity cytosol
YAL045C_d YAL045C YAL045C hom Dubious 1.40909808415334 0.0794030836459057 no 488 0.0602990497362925 237 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps YAL044W-A Unknown Unknown Unknown
YPR079W YPR079W MRL1 hom Verified 1.40780022800669 0.0795951164260562 no 489 0.0665800401180457 256 NA FT PROTEIN LOCALIZATION|VACUOLAR TRANSPORT GOLGI APPARATUS Membrane protein; has similarity to mammalian mannose-6-phosphate receptors; possibly functions as a sorting receptor in the delivery of vacuolar hydrolases; protein abundance increases in response to DNA replication stress vacuolar transport signal sequence binding late endosome|cytoplasm
YHR113W YHR113W APE4 hom Verified 1.40766026246977 0.0796158469141893 no 490 0.0695228065598768 340 NA FT PROTEOLYSIS Cytoplasmic aspartyl aminopeptidase that may also function in the vacuole; CVT pathway cargo protein; cleaves unblocked N-terminal acidic amino acids from peptide substrates; forms a 12-subunit homo-oligomer; M18 metalloprotease family proteolysis aminopeptidase activity fungal-type vacuole lumen|ribosome|cytoplasm
YML014W YML014W TRM9 hom Verified 1.40698831248945 0.0797154272351029 no 491 0.0655048119769102 330 NA FT RNA PROCESSING NUCLEUS tRNA methyltransferase; catalyzes modification of wobble bases in tRNA anticodons to 2, 5-methoxycarbonylmethyluridine and 5-methoxycarbonylmethyl-2-thiouridine; may act as part of a complex with Trm112p; deletion mutation increases translational infidelity, including amino acid misincorporation and -1 frameshifting, and also confers resistance to zymocin; null mutant displays activation of stress responses chronological cell aging|tRNA methylation|tRNA wobble uridine modification|response to stress tRNA (uracil) methyltransferase activity nucleus|cytoplasm
YLR416C_d YLR416C YLR416C hom Dubious 1.40558196394841 0.0799241474226743 no 492 0.0739293947997137 296 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR351C YLR351C NIT3 hom Verified 1.40286979708017 0.0803278344042865 no 493 0.0636113753169159 268 NA FT MITOCHONDRION Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member biological_process hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds mitochondrion|cytoplasm
YCR024C-A YCR024C-A PMP1 hom Verified 1.40094027878618 0.0806159663185759 no 494 0.105225348626311 416 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Regulatory subunit for the plasma membrane H(+)-ATPase Pma1p; small single-membrane span proteolipid; forms unique helix and positively charged cytoplasmic domain that is able to specifically segregate phosphatidylserines; PMP1 has a paralog, PMP2, that arose from the whole genome duplication cation transport enzyme regulator activity plasma membrane|membrane
YKR048C YKR048C NAP1 hom Verified 1.40009487942669 0.0807424541211549 no 495 0.0838491046778329 379 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION NUCLEUS|SITE OF POLARIZED GROWTH|CHROMOSOME Protein that interacts with mitotic cyclin Clb2p; required for the regulation of microtubule dynamics during mitosis; controls bud morphogenesis; involved in the transport of H2A and H2B histones to the nucleus; phosphorylated by CK2; protein abundance increases in response to DNA replication stress budding cell bud growth|M phase of mitotic cell cycle|nucleosome disassembly|protein import into nucleus|nucleosome assembly cyclin binding|histone binding nucleus|nuclear nucleosome|cytoplasm
YNL199C YNL199C GCR2 hom Verified 1.3981101684251 0.081039993409848 no 496 0.0961617136810826 406 NA FT TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY ENDOMEMBRANE SYSTEM|NUCLEUS Transcriptional activator of genes involved in glycolysis; interacts and functions with the DNA-binding protein Gcr1p positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter|regulation of glycolysis by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II activating transcription factor binding|RNA polymerase II transcription factor binding transcription factor activity nuclear envelope|nucleus
YKR032W_d YKR032W YKR032W hom Dubious 1.39753044318704 0.0811270592782544 no 497 0.0645446174828769 274 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YKL086W YKL086W SRX1 hom Verified 1.38737696180812 0.0826634231200526 no 498 0.0744172172924311 297 NA FT OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS NUCLEUS Sulfiredoxin; contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxin Tsa1p, which is formed upon exposure to oxidants; conserved in higher eukaryotes; protein abundance increases in response to DNA replication stress cellular response to oxidative stress sulfiredoxin activity nucleus|cytoplasm
YDR463W YDR463W STP1 hom Verified 1.3863847434153 0.0828147262779162 no 499 0.163885324952991 511 NA FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS|PLASMA MEMBRANE Transcription factor; undergoes proteolytic processing by SPS (Ssy1p-Ptr3p-Ssy5p)-sensor component Ssy5p in response to extracellular amino acids; activates transcription of amino acid permease genes and may have a role in tRNA processing; STP1 has a paralog, STP2, that arose from the whole genome duplication positive regulation of transcription, DNA-dependent|tRNA splicing, via endonucleolytic cleavage and ligation|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription plasma membrane|nucleus|cytoplasm
YLR373C YLR373C VID22 hom Verified 1.38507154911386 0.0830152952386476 no 500 0.0988522335585216 430 NA FT PROTEIN LOCALIZATION NUCLEUS|PLASMA MEMBRANE Glycosylated integral membrane protein localized to the plasma membrane; plays a role in fructose-1,6-bisphosphatase (FBPase) degradation; involved in FBPase transport from the cytosol to Vid (vacuole import and degradation) vesicles vacuolar protein catabolic process molecular_function integral to plasma membrane
YJL029C YJL029C VPS53 hom Verified 1.38459416133586 0.0830882988981069 no 501 0.0678681894823886 308 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT GOLGI APPARATUS Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; required for vacuolar protein sorting Golgi to vacuole transport|retrograde transport, endosome to Golgi molecular_function Golgi apparatus|GARP complex|cytoplasm
YBL087C YBL087C RPL23A hom Verified 1.38294784512222 0.0833404291807571 no 502 0.0850915291360112 304 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L23A; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23A has a paralog, RPL23B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YDR446W YDR446W ECM11 hom Verified 1.38065673348623 0.0836922652278038 no 503 0.0497857726278058 231 NA FT CELL CYCLE|CELL WALL ORG/BIOGENESIS NUCLEUS Non-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure fungal-type cell wall organization|reciprocal meiotic recombination molecular_function nucleus
YKL050C YKL050C YKL050C hom Verified 1.38001686043303 0.0837907268104315 no 504 0.0481697203553981 214 NA Protein of unknown function; the YKL050W protein is a target of the SCFCdc4 ubiquitin ligase complex and YKL050W transcription is regulated by Azf1p biological_process molecular_function cellular_component
YLR420W YLR420W URA4 hom Verified 1.37660823728681 0.0843167013882915 no 505 0.0931989839482133 374 NA FT NUCLEOTIDE METABOLISM NUCLEUS Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate 'de novo' pyrimidine nucleobase biosynthetic process|pyrimidine nucleotide biosynthetic process dihydroorotase activity nucleus|cytoplasm
YOL109W YOL109W ZEO1 hom Verified 1.37598723353721 0.0844127928892812 no 506 0.0899432271995136 329 NA FT CELL WALL ORG/BIOGENESIS MITOCHONDRION|PLASMA MEMBRANE Peripheral membrane protein of the plasma membrane that interacts with Mid2p; regulates the cell integrity pathway mediated by Pkc1p and Slt2p; the authentic protein is detected in a phosphorylated state in highly purified mitochondria fungal-type cell wall organization|response to stress molecular_function mitochondrial outer membrane|mitochondrion|extrinsic to plasma membrane|plasma membrane
YIL025C_d YIL025C YIL025C hom Dubious 1.37217759361921 0.08500407941685 no 507 0.115605215134049 424 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGR080W YGR080W TWF1 hom Verified 1.37164792460274 0.085086533492705 no 508 0.0738113090156643 305 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Twinfilin, highly conserved actin monomer-sequestering protein involved in regulation of the cortical actin cytoskeleton, composed of two cofilin-like regions, localizes actin monomers to sites of rapid filament assembly bipolar cellular bud site selection|actin polymerization or depolymerization|sequestering of actin monomers actin monomer binding mating projection tip|actin cortical patch
YMR063W YMR063W RIM9 hom Verified 1.3711959595986 0.0851569386948837 no 509 0.140784183098099 564 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Plasma membrane protein of unknown function; involved in the proteolytic activation of Rim101p in response to alkaline pH; interacts with Rim21p and Dfg16p to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; has similarity to A. nidulans PalI; ascospore formation molecular_function integral to membrane
YLL052C YLL052C AQY2 hom Verified 1.3670984264598 0.0857972282210398 no 510 0.0958505187451665 373 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains water transport water channel activity plasma membrane|endoplasmic reticulum membrane
YIL146C YIL146C ATG32 hom Verified 1.36398625385394 0.0862859460190722 no 511 0.069689728698971 285 NA FT CELL WALL ORG/BIOGENESIS MITOCHONDRION Mitochondrial outer membrane protein required to initiate mitophagy; recruits the autophagy adaptor protein Atg11p and the ubiquitin-like protein Atg8p to the mitochondrial surface to initiate mitophagy, the selective vacuolar degradation of mitochondria in response to starvation; can promote pexophagy when placed ectopically in the peroxisomal membrane fungal-type cell wall organization|mitochondrion degradation molecular_function integral to mitochondrial outer membrane
YOL138C YOL138C RTC1 hom Verified 1.36289195719093 0.0864582819280444 no 512 0.0887671498488696 371 NA Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; null mutation suppresses cdc13-1 temperature sensitivity; has N-terminal WD-40 repeats and a C-terminal RING motif biological_process molecular_function ribosome|fungal-type vacuole|Seh1-associated complex|extrinsic to fungal-type vacuolar membrane
YDL077C YDL077C VAM6 hom Verified 1.36052127299114 0.086832512869888 no 513 0.141085545689875 537 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p regulation of SNARE complex assembly|regulation of vacuole fusion, non-autophagic|piecemeal microautophagy of nucleus|vesicle-mediated transport|vacuole organization|vacuole fusion, non-autophagic Rab guanyl-nucleotide exchange factor activity|phosphatidylinositol binding fungal-type vacuole membrane|HOPS complex|fungal-type vacuole
YBR173C YBR173C UMP1 hom Verified 1.36024891158534 0.0868755846294562 no 514 0.0740883034387996 296 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE|PROTEOLYSIS NUCLEUS Short-lived chaperone required for correct maturation of the 20S proteasome; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its assembly proteasome assembly|response to DNA damage stimulus|ubiquitin-dependent protein catabolic process molecular_function nucleus|cytoplasm
YLR261C_d YLR261C VPS63 hom Dubious 1.35945378953419 0.0870014180870708 no 515 0.189385574583011 621 NA FF Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect Unknown Unknown Unknown
YMR254C_d YMR254C YMR254C hom Dubious 1.3551875506341 0.0876789050456809 no 516 0.0817406829143794 343 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR346C_p YLR346C YLR346C hom Uncharacterized 1.35515756165958 0.0876836812441774 no 517 0.0627569924523539 258 NA FT MITOCHONDRION Putative protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; YLR346C is not an essential gene biological_process molecular_function mitochondrion
YDR245W YDR245W MNN10 hom Verified 1.35415570812552 0.0878433531785124 no 518 0.0965880686032711 387 NA FT CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Subunit of a Golgi mannosyltransferase complex also containing Anp1p, Mnn9p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltransferase family N-glycan processing|cell wall mannoprotein biosynthetic process|substituted mannan metabolic process|barrier septum assembly alpha-1,6-mannosyltransferase activity alpha-1,6-mannosyltransferase complex
YOR258W YOR258W HNT3 hom Verified 1.35059476238271 0.0884126397585544 no 519 0.119560625632469 461 NA FT RESPONSE TO DNA DAMAGE NUCLEUS DNA 5' AMP hydrolase involved in DNA repair; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins; homolog of Aprataxin, a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxia; relative distribution to nuclear foci decreases upon DNA replication stress response to DNA damage stimulus DNA 5'-adenosine monophosphate hydrolase activity nucleus|cytoplasm
YCR084C YCR084C TUP1 hom Verified 1.34497123315299 0.0893172622867467 no 520 0.0829155954953967 327 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|RESPONSE TO NUTRIENT LEVELS NUCLEUS General repressor of transcription, forms complex with Cyc8p, involved in the establishment of repressive chromatin structure through interactions with histones H3 and H4, appears to enhance expression of some genes nucleosome positioning|regulation of transcription from RNA polymerase II promoter in response to osmotic stress|histone exchange|negative regulation of mating-type specific transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter by glucose|negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter in response to hypoxia|negative regulation of transcription from RNA polymerase II promoter during mitosis|Unknown ubiquitin binding|histone deacetylase binding|histone binding|phosphatidylinositol-3,5-bisphosphate binding|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription|mediator complex binding nucleus|transcriptional repressor complex
YGR121C YGR121C MEP1 hom Verified 1.34139571105843 0.089896004678999 no 521 0.0815261439127282 299 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation nitrogen utilization|ammonium transport ammonium transmembrane transporter activity integral to membrane|plasma membrane
YMR243C YMR243C ZRC1 hom Verified 1.34084412366271 0.089985533487468 no 522 0.0882472344550462 395 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Vacuolar membrane zinc transporter; transports zinc from cytosol to vacuole for storage; also has role in resistance to zinc shock resulting from sudden influx of zinc into cytoplasm; human ortholog SLC30A10 functions as a Mn transporter and mutations in SLC30A10 cause neurotoxic accumulation of Mn in liver and brain; ZRC1 has a paralog, COT1, that arose from the whole genome duplication cobalt ion transport|cellular zinc ion homeostasis|zinc ion transport|glutathione metabolic process zinc ion transmembrane transporter activity|inorganic cation transmembrane transporter activity integral to membrane|fungal-type vacuole
YJR145C YJR145C RPS4A hom Verified 1.33744506438249 0.0905387014675655 no 523 0.0837607286314082 348 NA FT TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4A has a paralog, RPS4B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic small ribosomal subunit|cytoplasm|90S preribosome
YPR045C YPR045C THP3 hom Verified 1.33633323046785 0.0907201897909047 no 524 0.0915637769605385 345 NA FT RNA PROCESSING NUCLEUS|CHROMOSOME Protein that forms a complex with Csn12p that is recruited to transcribed genes and may have a role in transcription elongation; possibly involved in splicing based on pre-mRNA accumulation defect for many intron-containing genes mRNA splicing, via spliceosome molecular_function nucleus|transcriptionally active chromatin
YGL045W YGL045W RIM8 hom Verified 1.33610231896136 0.0907579160751418 no 525 0.12781179691302 509 NA FF|FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family meiosis|protein processing|invasive growth in response to glucose limitation|ubiquitin-dependent endocytosis molecular_function internal side of plasma membrane
YMR102C_p YMR102C YMR102C hom Uncharacterized 1.33531180835673 0.0908871577214052 no 526 0.0806341227826189 349 NA Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene biological_process molecular_function cellular_component
YMR107W YMR107W SPG4 hom Verified 1.33467147811919 0.0909919462363674 no 527 0.0674258673305837 281 NA Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources biological_process molecular_function cellular_component
YLR209C YLR209C PNP1 hom Verified 1.33437079420726 0.0910411833521447 no 528 0.099973151466035 340 NA FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM Purine nucleoside phosphorylase, specifically metabolizes inosine and guanosine nucleosides; involved in the nicotinamide riboside salvage pathway guanosine catabolic process|inosine catabolic process|NAD biosynthesis via nicotinamide riboside salvage pathway|nicotinate nucleotide salvage nicotinamide riboside hydrolase activity|inosine nucleosidase activity|purine-nucleoside phosphorylase activity intracellular
YLR014C YLR014C PPR1 hom Verified 1.33299605488541 0.0912665492282827 no 529 0.12302932208622 401 NA FT TRANSCRIPTION FROM RNA POL II|NUCLEOTIDE METABOLISM NUCLEUS Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of URA1, URA3, URA4, and URA10, which are involved in de novo pyrimidine biosynthesis, in response to pyrimidine starvation; activity may be modulated by interaction with Tup1p positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding RNA polymerase II transcription factor activity|sequence-specific DNA binding|zinc ion binding nucleus
YOR138C YOR138C RUP1 hom Verified 1.33262048053048 0.091328190337139 no 530 0.102258239847799 394 NA FT NUCLEUS Protein that regulates Rsp5p, which is a HECT ubiquitin ligase; has a WW domain consensus motif of PPPSY (residues 131-135) that mediates binding of Rsp5p to Ubp2p; contains an UBA domain; relative distribution to the nucleus increases upon DNA replication stress protein deubiquitination protein binding nucleus|cytoplasm
YML075C YML075C HMG1 hom Verified 1.32849580354613 0.0920071844906673 no 531 0.0911402264860772 380 NA FT LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM HMG-CoA reductase; catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to the nuclear envelope; overproduction induces the formation of karmellae; forms foci at the nuclear periphery upon DNA replication stress ergosterol biosynthetic process|isopentenyl diphosphate biosynthetic process, mevalonate pathway hydroxymethylglutaryl-CoA reductase (NADPH) activity nuclear envelope|integral to membrane|endoplasmic reticulum membrane
YOR017W YOR017W PET127 hom Verified 1.3283483812977 0.0920315217807925 no 532 0.0745793619971388 315 NA FT RNA PROCESSING|MITOCHONDRION ORGANIZATION MITOCHONDRION Protein with a role in 5'-end processing of mitochondrial RNAs, located in the mitochondrial membrane mitochondrial RNA 5'-end processing molecular_function mitochondrial envelope|mitochondrion
YNR008W YNR008W LRO1 hom Verified 1.32716269827124 0.0922274343346573 no 533 0.0930560883099417 406 NA FT LIPID METABOLISM ENDOPLASMIC RETICULUM Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase lipid storage|triglyceride biosynthetic process phospholipid:diacylglycerol acyltransferase activity lipid particle|perinuclear endoplasmic reticulum
YMR142C YMR142C RPL13B hom Verified 1.32584657724206 0.0924452607138486 no 534 0.104442817755707 412 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L13B; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13B has a paralog, RPL13A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YNL101W YNL101W AVT4 hom Verified 1.32575113027127 0.0924610725847435 no 535 0.0835025633467997 345 NA FT VACUOLAR TRANSPORT Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters amino acid export from vacuole transporter activity|L-glutamine transmembrane transporter activity|L-isoleucine transmembrane transporter activity|L-tyrosine transmembrane transporter activity fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YOR028C YOR028C CIN5 hom Verified 1.32501997418589 0.0925822632453141 no 536 0.0730309180111442 269 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Basic leucine zipper (bZIP) transcription factor of the yAP-1 family; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; mediates pleiotropic drug resistance and salt tolerance; nuclearly localized under oxidative stress and sequestered in the cytoplasm by Lot6p under reducing conditions; CIN5 has a paralog, YAP6, that arose from the whole genome duplication hyperosmotic salinity response|response to drug|hyperosmotic response|regulation of transcription from RNA polymerase II promoter repressing transcription factor binding|sequence-specific DNA binding nucleus|cytoplasm
YPL052W YPL052W OAZ1 hom Verified 1.32448469492596 0.0926710613844181 no 537 0.0829978859893588 349 NA FT TRANSLATION|PROTEOLYSIS Regulator of ornithine decarboxylase (Spe1p), antizyme that binds to Spe1p to stimulate ubiquitin-independent degradation by the proteasome; binding of polyamines to nascent Oaz1p during translation stimulates +1 ribosomal frameshifting, allowing translation of full-length Oaz1p Unknown|regulation of proteasomal protein catabolic process ornithine decarboxylase inhibitor activity cytoplasm
YNL049C YNL049C SFB2 hom Verified 1.32412717764933 0.0927304054455914 no 538 0.0790211656137382 317 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Component of the Sec23p-Sfb2p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb3p cargo loading into COPII-coated vesicle signal sequence binding COPII vesicle coat
YHR198C YHR198C AIM18 hom Verified 1.32403881294782 0.0927450773758695 no 539 0.0945708880038394 380 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss biological_process molecular_function mitochondrion
YLR342W YLR342W FKS1 hom Verified 1.3236961584157 0.092801987409029 no 540 0.094527188252464 372 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM MITOCHONDRION|PLASMA MEMBRANE|CYTOSKELETON Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling (1->3)-beta-D-glucan biosynthetic process|positive regulation of endocytosis|regulation of cell size 1,3-beta-D-glucan synthase activity mitochondrion|1,3-beta-D-glucan synthase complex|integral to membrane|plasma membrane|cellular bud neck|cellular bud tip|actin cortical patch
YOR360C YOR360C PDE2 hom Verified 1.32309081300459 0.0929025897514437 no 541 0.109824168760862 381 NA FT SIGNALING NUCLEUS High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon cAMP-mediated signaling 3',5'-cyclic-AMP phosphodiesterase activity nucleus|cytoplasm
YIL050W YIL050W PCL7 hom Verified 1.32183894133742 0.0931108940291162 no 542 0.055769016487507 256 NA FT CELL CYCLE|OXIDATION-REDUCTION PROCESS|CELL DIVISION|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Pho85p cyclin of the Pho80p subfamily, forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism, expression is cell-cycle regulated regulation of glycogen catabolic process|regulation of cyclin-dependent protein kinase activity|regulation of protein stability|regulation of glycogen biosynthetic process cyclin-dependent protein kinase regulator activity cyclin-dependent protein kinase holoenzyme complex|nucleus
YPR108W-A_p YPR108W-A YPR108W-A hom Uncharacterized 1.31981571112671 0.0934482773748578 no 543 0.10335886493418 366 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YLL017W YLL017W YLL017W hom pseudogene 1.31927858786729 0.0935379967493067 no 544 0.0596027171668143 230 NA FT SIGNALING Non-essential Ras guanine nucleotide exchange factor (GEF); localized to the membrane; expressed in poor nutrient conditions and on nonfermentable carbon sources; contains a stop codon in S288C, full-length gene includes YLL016W; SDC25 has a paralog, CDC25, that arose from the whole genome duplication Ras protein signal transduction Ras guanyl-nucleotide exchange factor activity membrane
YBR255W YBR255W MTC4 hom Verified 1.31903285932705 0.0935790636716688 no 545 0.117452393088943 421 NA Protein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; mtc4 is synthetically sick with cdc13-1 biological_process molecular_function cytoplasm
YBR057C YBR057C MUM2 hom Verified 1.31652592448544 0.0939987915128471 no 546 0.0998673608279552 374 NA FT CELL CYCLE Cytoplasmic protein essential for meiotic DNA replication and sporulation; interacts with Orc2p, which is a component of the origin recognition complex premeiotic DNA replication molecular_function cytoplasm
YDR395W YDR395W SXM1 hom Verified 1.31575759506793 0.0941277080877693 no 547 0.0952095361555556 374 NA FT PROTEIN LOCALIZATION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS Nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucleoplasm; similar to Nmd5p, Cse1p, Lph2p, and the human cellular apoptosis susceptibility protein, CAS1 mRNA export from nucleus|nucleocytoplasmic transport protein transporter activity integral to membrane|nucleus|cytoplasm
YHR142W YHR142W CHS7 hom Verified 1.3153662388816 0.0941934231397254 no 548 0.218159089632964 730 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein of unknown function; may be involved in chitin biosynthesis by regulation of Chs3p export from the ER; relocalizes from bud neck to ER upon DNA replication stress protein folding|ER to Golgi vesicle-mediated transport|fungal-type cell wall chitin biosynthetic process unfolded protein binding integral to membrane|endoplasmic reticulum membrane
YOL052C YOL052C SPE2 hom Verified 1.31460288516845 0.0943216999861884 no 549 0.107214406164032 338 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM NUCLEUS S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically spermidine biosynthetic process|spermine biosynthetic process|pantothenate biosynthetic process adenosylmethionine decarboxylase activity nucleus|cytoplasm
YHR041C YHR041C SRB2 hom Verified 1.31141227107238 0.0948592576348858 no 550 0.136989385816531 482 NA FT TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|RESPONSE TO NUTRIENT LEVELS NUCLEUS RNA POL II, HOLOENZYME Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to chemical stimulus|RNA polymerase II transcriptional preinitiation complex assembly|negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to nutrient levels|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly|core RNA polymerase II binding transcription factor activity|RNA polymerase II transcription factor recruiting transcription factor activity|TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly|protein domain specific binding core mediator complex
YOR140W YOR140W SFL1 hom Verified 1.31110556057299 0.0949110511940681 no 551 0.091238261081716 362 NA FT TRANSCRIPTION FROM RNA POL II|GENE SILENCING NUCLEUS Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p gene silencing|Unknown|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II repressing transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity nucleus
YOR273C YOR273C TPO4 hom Verified 1.31007574449287 0.0950851064952392 no 552 0.144162864039861 547 NA FF|FT PLASMA MEMBRANE Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane spermidine transport|spermine transport spermidine transmembrane transporter activity|spermine transmembrane transporter activity fungal-type vacuole membrane|integral to membrane|plasma membrane
YHR063C YHR063C PAN5 hom Verified 1.306353662234 0.0957161580484978 no 553 0.107993179026361 403 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM 2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panE pantothenate biosynthetic process 2-dehydropantoate 2-reductase activity cytoplasm
YML094W YML094W GIM5 hom Verified 1.30587426237522 0.0957976602196443 no 554 0.0988135815160126 421 NA FT PROTEIN COMPLEX ORG/BIOGENESIS Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it tubulin complex assembly tubulin binding prefoldin complex|cytoplasm
YGR192C YGR192C TDH3 hom Verified 1.30574730076996 0.0958192533513714 no 555 0.101000245863454 392 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Glyceraldehyde-3-phosphate dehydrogenase, isozyme 3; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; TDH3 has a paralog, TDH2, that arose from the whole genome duplication gluconeogenesis|reactive oxygen species metabolic process|glycolysis|apoptotic process glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity mitochondrion|fungal-type cell wall|lipid particle|plasma membrane|cytoplasm
YMR318C YMR318C ADH6 hom Verified 1.30369652131236 0.0961685379924868 no 556 0.0926917975389352 353 NA FT OXIDATION-REDUCTION PROCESS NADPH-dependent medium chain alcohol dehydrogenase; has broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance; protein abundance increases in response to DNA replication stress cellular aldehyde metabolic process|furaldehyde metabolic process|alcohol metabolic process hydroxymethylfurfural reductase (NADH) activity|hydroxymethylfurfural reductase (NADPH) activity|alcohol dehydrogenase (NADP+) activity cellular_component
YGL100W YGL100W SEH1 hom Verified 1.30159765210694 0.0965269814340683 no 557 0.116896663959102 484 NA FF|FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|PLASMA MEMBRANE NUCLEAR PORE Component of two distinct complexes; subunit of the Nup84 nuclear pore sub-complex (NPC) and the Seh1-associated (SEA) complex; the the NUP84 subcomplex contributes to nucleocytoplasmic transport and NPC biogenesis; the SEA complex is a coatamer-related complex that associates dynamically with the vacuole; homologous to human SEH1 nucleocytoplasmic transport structural constituent of nuclear pore fungal-type vacuole membrane|integral to membrane|nuclear pore|Seh1-associated complex|nuclear pore outer ring
YLR406C YLR406C RPL31B hom Verified 1.30147942448328 0.0965472014290259 no 558 0.131020861443701 476 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L31B; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31B has a paralog, RPL31A, that arose from the whole genome duplication cytoplasmic translation|regulation of translational fidelity structural constituent of ribosome cytosolic large ribosomal subunit
YKL047W_p YKL047W ANR2 hom Uncharacterized 1.29940313372597 0.0969028084052877 no 559 0.0969232422115871 411 NA Putative protein of unknown function, predicted to be palmitoylated; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm biological_process molecular_function cytoplasm
YOR180C YOR180C DCI1 hom Verified 1.29924706964098 0.0969295763567694 no 560 0.11872352284222 450 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS Peroxisomal protein; identification as a delta(3,5)-delta(2,4)-dienoyl-CoA isomerase involved in fatty acid metabolism is disputed fatty acid beta-oxidation dodecenoyl-CoA delta-isomerase activity peroxisomal matrix
YGR104C YGR104C SRB5 hom Verified 1.29234187903206 0.0981193874472729 no 561 0.107524572442102 435 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; required for proper termination of transcription for some genes; involved in telomere maintenance transcriptional open complex formation at RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter core RNA polymerase II binding transcription factor activity|RNA polymerase II transcription factor recruiting transcription factor activity|TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly core mediator complex
YBR106W YBR106W PHO88 hom Verified 1.29119385082009 0.0983182334255511 no 562 0.174033286465252 659 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations phosphate ion transport molecular_function mitochondrion|membrane
YDR289C YDR289C RTT103 hom Verified 1.28784100144251 0.0989006581827461 no 563 0.119097474990311 478 NA FT RNA PROCESSING NUCLEUS|CHROMOSOME Protein that interacts with exonuclease Rat1p and Rai1p and plays a role in transcription termination by RNA polymerase II, has an RPR domain (carboxy-terminal domain interacting domain); also involved in regulation of Ty1 transposition negative regulation of transposition, RNA-mediated|mRNA 3'-end processing RNA polymerase II core binding nuclear chromatin|site of double-strand break
YLR446W_p YLR446W YLR446W hom Uncharacterized 1.28638645767534 0.0991541111358881 no 564 0.0918569522273167 394 NA FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Putative hexokinase; transcript is upregulated during sporulation and the unfolded protein response; YLR446W is not an essential gene biological_process molecular_function cellular_component
YJR102C YJR102C VPS25 hom Verified 1.28527940560128 0.0993473320773224 no 565 0.162133245028583 654 NA FF|FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome negative regulation of transcription from RNA polymerase II promoter by glucose|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein targeting to vacuole structural molecule activity ESCRT II complex
YIL034C YIL034C CAP2 hom Verified 1.28490613874885 0.0994125427625886 no 566 0.073762743405912 403 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Beta subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress barbed-end actin filament capping|filamentous growth actin filament binding actin filament|F-actin capping protein complex|mating projection tip|actin cortical patch
YEL029C YEL029C BUD16 hom Verified 1.2842009414876 0.0995358279352068 no 567 0.146692654627651 524 NA FT CELL CYCLE|CELL DIVISION|COFACTOR METABOLISM NUCLEUS Putative pyridoxal kinase, a key enzyme involved in pyridoxal 5'-phosphate synthesis, the active form of vitamin B6; required for genome integrity; involved in bud-site selection; similarity to yeast BUD17 and human pyridoxal kinase (PDXK) pyridoxal phosphate biosynthetic process|cellular bud site selection pyridoxal kinase activity cytoplasm
YNL227C YNL227C JJJ1 hom Verified 1.2824591299638 0.0998408165704892 no 568 0.0779751704469117 312 NA FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS|MITOCHONDRION RIBOSOME Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis ribosomal subunit export from nucleus|ribosomal large subunit biogenesis|endocytosis|regulation of cell size|rRNA processing ATPase activator activity cytosol|mitochondrion|cytosolic large ribosomal subunit|nucleolus|cytoplasm
YDR137W YDR137W RGP1 hom Verified 1.28216675398581 0.09989207800976 no 569 0.188801954180545 617 NA FF|FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|CELL DIVISION ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p retrograde transport, endosome to Golgi guanyl-nucleotide exchange factor activity Golgi apparatus|Ric1p-Rgp1p complex|Golgi membrane|guanyl-nucleotide exchange factor complex
YHR025W YHR025W THR1 hom Verified 1.28129841000749 0.100044435581778 no 570 0.120926306044029 448 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway threonine biosynthetic process|methionine metabolic process|isoleucine metabolic process|homoserine metabolic process homoserine kinase activity cellular_component
YOL128C YOL128C YGK3 hom Verified 1.28030758736104 0.100218490154498 no 571 0.105054592418062 378 NA FT PROTEOLYSIS|PROTEIN PHOSPHORYLATION Protein kinase related to mammalian glycogen synthase kinases of the GSK-3 family; GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradation proteolysis|protein phosphorylation|response to stress protein serine/threonine kinase activity|protein kinase activity cellular_component
YGL227W YGL227W VID30 hom Verified 1.27876490415193 0.100489928099778 no 572 0.100928235043559 361 NA FT KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS NUCLEUS Central component of GID Complex, involved in FBPase degradation; interacts strongly with Gid8p to serve as a scaffold for other GID Complex subunits; contains SPRY domain and 3 domains that are also found in Gid8p - LisH, CTLH, and CRA; required for association of Vid vesicles and actin patches in vacuole import and degradation pathway; shifts the balance of nitrogen metabolism toward glutamate production; localizes to the nucleus and the cytoplasm regulation of nitrogen utilization|negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|vacuolar protein catabolic process molecular_function nucleus|GID complex|cytoplasm
YBR089C-A YBR089C-A NHP6B hom Verified 1.27775004586657 0.100668786542318 no 573 0.0761690464298562 297 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME High-mobility group (HMG) protein, binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Ap; homologous to mammalian HMGB1 and HMGB2; NHP6B has a paralog, NHP6A, that arose from the whole genome duplication RNA polymerase III transcriptional preinitiation complex assembly|chromatin remodeling|transcription from RNA polymerase II promoter nucleosome binding|DNA binding, bending|sequence-specific DNA binding nucleus
YBL072C YBL072C RPS8A hom Verified 1.27677842641254 0.100840242040442 no 574 0.0945752123659015 428 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S8, no bacterial homolog; RPS8A has a paralog, RPS8B, that arose from the whole genome duplication cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit|90S preribosome
YMR183C YMR183C SSO2 hom Verified 1.27676699118944 0.100842261208411 no 575 0.0874314124319178 367 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p Golgi to plasma membrane transport|ascospore-type prospore assembly|vesicle fusion phosphatidic acid binding|SNAP receptor activity endoplasmic reticulum|plasma membrane|prospore membrane|cytoplasm
YPL133C YPL133C RDS2 hom Verified 1.27590729418093 0.100994146146319 no 576 0.0739443973290252 297 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|SIGNALING|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS NUCLEUS Transcription factor involved in regulating gluconeogenesis and glyoxylate cycle genes; member of the zinc cluster family of proteins; confers resistance to ketoconazole positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source|positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter|cellular response to xenobiotic stimulus|positive regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus|cytoplasm
YMR158W-B_d YMR158W-B YMR158W-B hom Dubious 1.27343370632048 0.101432091497988 no 577 0.08601082472686 369 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene ATG16/YMR159C Unknown Unknown Unknown
YPR060C YPR060C ARO7 hom Verified 1.26962598431989 0.102108944525006 no 578 0.151610944919101 603 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Chorismate mutase, catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis aromatic amino acid family biosynthetic process chorismate mutase activity nucleus|cytoplasm
YFL034C-A YFL034C-A RPL22B hom Verified 1.26652223902387 0.102663086294563 no 579 0.110396552139758 441 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L22B; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22B has a paralog, RPL22A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YML055W YML055W SPC2 hom Verified 1.26646100928329 0.102674040177269 no 580 0.122449048394683 477 NA FT PROTEIN LOCALIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC25 signal peptide processing|protein targeting to ER peptidase activity signal peptidase complex
YOR235W_d YOR235W IRC13 hom Dubious 1.26628675952654 0.102705217771827 no 581 0.142096427317871 508 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays increased levels of spontaneous Rad52 foci Unknown Unknown Unknown
YPR171W YPR171W BSP1 hom Verified 1.26595292662492 0.102764967958457 no 582 0.104677072852905 390 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON Adapter that links synaptojanins Inp52p and Inp53p to the cortical actin cytoskeleton actin cortical patch localization protein binding, bridging mating projection tip|membrane|cellular bud neck|actin cortical patch|cellular bud tip
YPR131C YPR131C NAT3 hom Verified 1.26553078619542 0.102840559793686 no 583 0.101088821377 397 NA FT MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION Catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met mitochondrion inheritance|N-terminal peptidyl-methionine acetylation|cytoskeleton organization peptide alpha-N-acetyltransferase activity NatB complex|cytoplasm
YBR248C YBR248C HIS7 hom Verified 1.26467510164276 0.102993909434875 no 584 0.0925128161916608 352 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM Imidazole glycerol phosphate synthase (glutamine amidotransferase:cyclase), catalyzes the fifth step of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR), a purine precursor purine nucleoside monophosphate biosynthetic process|histidine biosynthetic process imidazoleglycerol-phosphate synthase activity intracellular
YML007C-A_p YML007C-A YML007C-A hom Uncharacterized 1.26113790964 0.103629582147282 no 585 0.125990561495994 568 NA FF|FT MITOCHONDRION Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria biological_process molecular_function mitochondrion
YKR105C_p YKR105C VBA5 hom Uncharacterized 1.260257934313 0.103788164768996 no 586 0.101049449565764 399 NA Plasma membrane protein of the Major Facilitator Superfamily (MFS); involved in amino acid uptake and drug sensitivity; similar to Vba3p biological_process molecular_function integral to membrane
YDR285W YDR285W ZIP1 hom Verified 1.25953539125377 0.10391850767222 no 587 0.109025140903767 423 NA FT CELL CYCLE NUCLEUS|CHROMOSOME Transverse filament protein of the synaptonemal complex; required for normal levels of meiotic recombination and pairing between homologous chromosome during meiosis; potential Cdc28p substrate synapsis|reciprocal meiotic recombination chromatin binding|SUMO polymer binding transverse filament
YLR266C YLR266C PDR8 hom Verified 1.2580720871161 0.104182843496858 no 588 0.0924457177614816 380 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Transcription factor; targets include ATP-binding cassette (ABC) transporters, major facilitator superfamily transporters, and other genes involved in the pleiotropic drug resistance (PDR) phenomenon; PDR8 has a paralog, YRR1, that arose from the whole genome duplication positive regulation of transcription from RNA polymerase II promoter in response to stress RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|sequence-specific DNA binding nucleus
YGL034C_d YGL034C YGL034C hom Dubious 1.25714578350273 0.104350425604765 no 589 0.11939389569129 421 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR015W YLR015W BRE2 hom Verified 1.25665054772705 0.104440101224745 no 590 0.139479310271059 540 NA FT CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Subunit of COMPASS (Set1C) complex, which methylates Lys4 of histone H3 and functions in silencing at telomeres; has a C-terminal Sdc1 Dpy-30 Interaction (SDI) domain that mediates binding to Sdc1p; similar to trithorax-group protein ASH2L histone H3-K4 methylation|telomere maintenance|histone H3-K4 trimethylation|chromatin silencing at telomere histone methyltransferase activity (H3-K4 specific) Set1C/COMPASS complex
YDR439W YDR439W LRS4 hom Verified 1.25498497895335 0.104742106461068 no 591 0.120821096728413 498 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CHROMOSOME SEGREGATION|GENE SILENCING NUCLEUS|CHROMOSOME KINETOCHORE Nucleolar protein that forms a complex with Csm1p, and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation rDNA condensation|chromatin silencing at rDNA|homologous chromosome segregation|protein localization to nucleolar rDNA repeats molecular_function nucleolus|nucleus|monopolin complex
YDR300C YDR300C PRO1 hom Verified 1.25457509223381 0.104816525055047 no 592 0.108693384545187 386 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Gamma-glutamyl kinase; catalyzes the first step in proline biosynthesis; PRO1 has a paralog, YHR033W, that arose from the whole genome duplication proline biosynthetic process glutamate 5-kinase activity cytoplasm
YOR316C YOR316C COT1 hom Verified 1.25228616026145 0.105232805019007 no 593 0.119397314231854 437 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium; protein abundance increases in response to DNA replication stress; COT1 has a paralog, ZRC1, that arose from the whole genome duplication cellular zinc ion homeostasis|cobalt ion transport|zinc ion transport cobalt ion transmembrane transporter activity|zinc ion transmembrane transporter activity|inorganic cation transmembrane transporter activity mitochondrion|integral to membrane|fungal-type vacuole
YLR104W_p YLR104W LCL2 hom Uncharacterized 1.24887122619497 0.105856088643768 no 594 0.103102789731182 349 NA FT PROTEOLYSIS Putative protein of unknown function; mutant is deficient in amounts of cell wall mannosylphosphate and has long chronological lifespan; genetic interactions suggest a role in ER-associated protein degradation (ERAD) ER-associated protein catabolic process molecular_function cellular_component
YGR051C_d YGR051C YGR051C hom Dubious 1.24857741066067 0.105909839381555 no 595 0.0934338315160939 379 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene Unknown Unknown Unknown
YPL185W_d YPL185W YPL185W hom Dubious 1.24806010284531 0.106004523823479 no 596 0.112320147822906 362 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C Unknown Unknown Unknown
YPL096W YPL096W PNG1 hom Verified 1.24685494668663 0.10622534446434 no 597 0.114590976415239 395 NA FT RESPONSE TO DNA DAMAGE|PROTEOLYSIS NUCLEUS|MITOCHONDRION Conserved peptide N-glycanase required for deglycosylation of misfolded glycoproteins during proteasome-dependent degradation; localizes to the cytoplasm and nucleus; activity is enhanced by interaction with Rad23p misfolded or incompletely synthesized protein catabolic process|protein deglycosylation peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity cytosol|mitochondrion|nucleus
YIL103W YIL103W DPH1 hom Verified 1.24148590751057 0.107213150488085 no 598 0.111331390856782 420 NA Protein required, along with Dph2p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph2p and Kti11p peptidyl-diphthamide biosynthetic process from peptidyl-histidine molecular_function cytoplasm
YGL005C YGL005C COG7 hom Verified 1.23969976888634 0.107543231336263 no 599 0.265491203088139 930 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|MITOCHONDRION|GOLGI APPARATUS Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments intra-Golgi vesicle-mediated transport|CVT pathway molecular_function mitochondrion|Golgi transport complex
YLR182W YLR182W SWI6 hom Verified 1.23895926681148 0.107680291651728 no 600 0.138891550607904 495 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE NUCLEUS Transcription cofactor; forms complexes with Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; also binds Stb1p to regulate transcription at START; cell wall stress induces phosphorylation by Mpk1p, which regulates Swi6p localization; required for the unfolded protein response, independently of its known transcriptional coactivators positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription involved in G1/S phase of mitotic cell cycle|positive regulation of reciprocal meiotic recombination|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription coactivator activity SBF transcription complex|MBF transcription complex|nucleus|cytoplasm
YCR075C YCR075C ERS1 hom Verified 1.23609463487747 0.108211694462442 no 601 0.0958695929295919 422 NA Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains L-cystine transport|transmembrane transport L-cystine transmembrane transporter activity endosome|integral to membrane|fungal-type vacuole
YDR218C YDR218C SPR28 hom Verified 1.2346524262004 0.108479944267136 no 602 0.0865992615327725 330 NA FT CELL CYCLE|CELL DIVISION SITE OF POLARIZED GROWTH|CYTOSKELETON Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; meiotic septin expressed at high levels during meiotic divisions and ascospore formation sexual sporulation resulting in formation of a cellular spore structural molecule activity spindle microtubule|meiotic spindle|septin complex|prospore membrane|ascospore wall
YNL086W_p YNL086W SNN1 hom Uncharacterized 1.23086270620624 0.10918710895973 no 603 0.0862635774267434 325 NA Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to endosomes biological_process molecular_function endosome|BLOC-1 complex
YGL249W YGL249W ZIP2 hom Verified 1.22918772481699 0.109500715092611 no 604 0.0795531098801411 293 NA FT CELL CYCLE|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Meiosis-specific protein; involved in normal synaptonemal complex formation and pairing between homologous chromosomes during meiosis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress synaptonemal complex assembly|synapsis|reciprocal meiotic recombination molecular_function synaptonemal complex
YOL060C YOL060C MAM3 hom Verified 1.22795585582697 0.109731769907482 no 605 0.0977853480277978 393 NA FT ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS Protein required for normal mitochondrial morphology, has similarity to hemolysins cellular manganese ion homeostasis|mitochondrion organization molecular_function fungal-type vacuole membrane|integral to membrane
YJR148W YJR148W BAT2 hom Verified 1.22451068810385 0.110379818424476 no 606 0.0961480871423582 374 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Cytosolic branched-chain amino acid (BCAA) aminotransferase, preferentially involved in BCAA catabolism; homolog of murine ECA39; highly expressed during stationary phase and repressed during logarithmic phase branched-chain amino acid catabolic process|branched-chain amino acid biosynthetic process branched-chain-amino-acid transaminase activity nucleus|cytoplasm
YBR293W YBR293W VBA2 hom Verified 1.22377755954804 0.110518075957816 no 607 0.108826073739238 426 NA Permease of basic amino acids in the vacuolar membrane basic amino acid transport|transmembrane transport basic amino acid transmembrane transporter activity|drug transmembrane transporter activity fungal-type vacuole membrane|integral to membrane
YDR540C YDR540C IRC4 hom Verified 1.2235913008456 0.110553221446167 no 608 0.153796258788183 588 NA FF|FT NUCLEUS Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus mitotic recombination molecular_function nucleus|cytoplasm
YNL173C YNL173C MDG1 hom Verified 1.21916867312372 0.111390089684633 no 609 0.125477470702307 476 NA FT SIGNALING PLASMA MEMBRANE Plasma membrane protein involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations pheromone-dependent signal transduction involved in conjugation with cellular fusion molecular_function membrane raft|plasma membrane
YGL134W YGL134W PCL10 hom Verified 1.2180901067091 0.111594866512136 no 610 0.0812584339509239 336 NA FT CELL CYCLE|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|GEN. OF PRECURSOR METABOLITES AND ENERGY Pho85p cyclin; recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate negative regulation of glycogen biosynthetic process|regulation of cyclin-dependent protein kinase activity cyclin-dependent protein kinase regulator activity cyclin-dependent protein kinase holoenzyme complex
YHR162W YHR162W MPC2 hom Verified 1.21740893116623 0.111724333324851 no 611 0.110003279157238 428 NA Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; more highly expressed in glucose-containing minimal medium than in lactate-containing medium mitochondrial pyruvate transport pyruvate transmembrane transporter activity mitochondrion|integral to mitochondrial inner membrane
YDR156W YDR156W RPA14 hom Verified 1.21616400129746 0.111961226978732 no 612 0.0866989662130896 341 NA FT NUCLEUS RNA polymerase I subunit A14 transcription of nuclear large rRNA transcript from RNA polymerase I promoter|regulation of cell size molecular_function DNA-directed RNA polymerase I complex
YDR259C YDR259C YAP6 hom Verified 1.21557381456387 0.112073657096984 no 613 0.089378273960011 351 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Basic leucine zipper (bZIP) transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; overexpression increases sodium and lithium tolerance; computational analysis suggests a role in regulation of expression of genes involved in carbohydrate metabolism; YAP6 has a paralog, CIN5, that arose from the whole genome duplication negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding transcription factor recruiting transcription factor activity|sequence-specific DNA binding RNA polymerase II transcription factor activity|sequence-specific DNA binding nucleus
YLR461W YLR461W PAU4 hom Verified 1.21536185371581 0.112114055167263 no 614 0.116900707085569 437 NA Member of the seripauperin multigene family encoded mainly in subtelomeric regions; active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme biological_process molecular_function cellular_component
YOR042W YOR042W CUE5 hom Verified 1.21451608427899 0.11227535580211 no 615 0.122122703979314 441 NA Protein containing a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern biological_process ubiquitin binding cytoplasm
YER044C-A YER044C-A MEI4 hom Verified 1.21415371437594 0.112344515781809 no 616 0.102545178119913 407 NA FT CELL CYCLE NUCLEUS|CHROMOSOME Meiosis-specific protein involved in double-strand break formation during meiotic recombination; required for chromosome synapsis and production of viable spores meiotic DNA double-strand break formation molecular_function condensed nuclear chromosome
YLR077W YLR077W FMP25 hom Verified 1.21136569753729 0.112877639960998 no 617 0.118081088282926 432 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial inner membrane protein required for an early step in assembly of respiratory complex III (cytochrome bc1 complex); mRNA is targeted to mitochondria mitochondrial respiratory chain complex III assembly molecular_function mitochondrion|integral to mitochondrial inner membrane
YKL020C YKL020C SPT23 hom Verified 1.21060865181576 0.113022713410037 no 618 0.0973984317897058 403 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|GENE SILENCING ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Mga2p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting cellular response to cold|positive regulation of unsaturated fatty acid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette DNA binding integral to endoplasmic reticulum membrane|nucleus
YML123C YML123C PHO84 hom Verified 1.20961353682917 0.11321361066488 no 619 0.157698388401662 570 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p; cells overexpressing Pho84p accumulate heavy metals but do not develop symptoms of metal toxicity phosphate ion transport|manganese ion transport|polyphosphate metabolic process manganese ion transmembrane transporter activity|inorganic phosphate transmembrane transporter activity integral to membrane|integral to plasma membrane
YPL186C YPL186C UIP4 hom Verified 1.20932870096082 0.113268294294475 no 620 0.141252621890834 458 NA FT ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION Protein that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope biological_process molecular_function mitochondrial outer membrane|nuclear envelope|endoplasmic reticulum
YGR050C_p YGR050C YGR050C hom Uncharacterized 1.20767121435362 0.113586877310394 no 621 0.100045807238494 404 NA Protein of unknown function; mRNA identified as translated by ribosome profiling data biological_process molecular_function cellular_component
YPL253C YPL253C VIK1 hom Verified 1.20638310015256 0.113834904602114 no 622 0.117120989420719 473 NA FT CELL CYCLE|CHROMOSOME SEGREGATION NUCLEUS|CYTOSKELETON Protein that forms a complex with Kar3p at the spindle pole body, possible regulator of Kar3p function in microtubule-mediated processes; required for sister chromatid cohesion; has similarity to Cik1p microtubule-based process|mitotic sister chromatid cohesion microtubule motor activity kinesin complex|spindle pole body
YML073C YML073C RPL6A hom Verified 1.20632481207662 0.113846137132602 no 623 0.112801502019315 401 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal 60S subunit protein L6A; N-terminally acetylated; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6A has a paralog, RPL6B, that arose from the whole genome duplication cytoplasmic translation|ribosomal large subunit assembly structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YNL329C YNL329C PEX6 hom Verified 1.20385265677943 0.114323266560848 no 624 0.12315468371322 474 NA FT PROTEIN LOCALIZATION|SIGNALING|PEROXISOME ORGANIZATION AAA-peroxin that heterodimerizes with AAA-peroxin Pex1p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol protein import into peroxisome matrix, receptor recycling|replicative cell aging ATPase activity|protein heterodimerization activity cytosol|peroxisome
YNL193W_p YNL193W YNL193W hom Uncharacterized 1.19869407058578 0.115323462239368 no 625 0.0983686467790178 420 NA Putative protein of unknown function; exhibits a two-hybrid interaction with Yhr151cp in a large-scale analysis biological_process molecular_function cellular_component
YOR314W_d YOR314W YOR314W hom Dubious 1.19793806534199 0.115470564661036 no 626 0.110750108110977 424 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGL121C YGL121C GPG1 hom Verified 1.19786362841665 0.115485055698819 no 627 0.0906121482952004 348 NA FT SIGNALING Proposed gamma subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p; involved in regulation of pseudohyphal growth; requires Gpb1p or Gpb2p to interact with Gpa2p; overproduction causes prion curing signal transduction|invasive growth in response to glucose limitation signal transducer activity cellular_component
YER113C YER113C TMN3 hom Verified 1.1967263603373 0.115706614513247 no 628 0.105721932313262 437 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn2p; member of Transmembrane Nine family with 9 transmembrane segments; localizes to Golgi; induced by 8-methoxypsoralen plus UVA irradiation cellular copper ion homeostasis|vacuolar transport|pseudohyphal growth|invasive growth in response to glucose limitation molecular_function COPI-coated vesicle|integral to membrane|Golgi apparatus
YDL156W YDL156W CMR1 hom Verified 1.19585128998866 0.115877298238754 no 629 0.128007580689176 467 NA FT NUCLEUS|CHROMOSOME DNA-binding protein with preference for UV-damaged DNA; protein sequence contains three WD domains (WD-40 repeat); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; potential regulatory target of Mbp1p, which binds to the promoter region; co-localizes with Hos2p in nuclear foci in response to DNA damage by MMS biological_process DNA binding nuclear chromatin|nucleus|cytoplasm
YMR252C_p YMR252C YMR252C hom Uncharacterized 1.19426938702578 0.116186304244659 no 630 0.097609610399588 406 NA FT MITOCHONDRION Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YMR252C is not an essential gene biological_process molecular_function mitochondrion
YGR121W-A_p YGR121W-A YGR121W-A hom Uncharacterized 1.19376792943396 0.116284380003979 no 631 0.109286117429926 396 NA Putative protein of unknown function biological_process molecular_function cellular_component
YER081W YER081W SER3 hom Verified 1.19306396180727 0.116422162046727 no 632 0.117814247911302 396 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS 3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER3 has a paralog, SER33, that arose from the whole genome duplication serine family amino acid biosynthetic process phosphoglycerate dehydrogenase activity cytoplasm
YDL124W YDL124W YDL124W hom Verified 1.19105964991584 0.116815084372231 no 633 0.0885076546027911 369 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS NUCLEUS NADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress cellular response to oxidative stress|cellular ketone metabolic process|cellular amide metabolic process|cellular aromatic compound metabolic process alpha-keto amide reductase activity|aldo-keto reductase (NADP) activity|alditol:NADP+ 1-oxidoreductase activity|alpha-keto ester reductase activity nucleus|plasma membrane|cytoplasm
YMR302C YMR302C YME2 hom Verified 1.18949632789086 0.117122207582379 no 634 0.114990433361623 455 NA FT RNA PROCESSING|MITOCHONDRION ORGANIZATION MITOCHONDRION Integral inner mitochondrial membrane protein with a role in maintaining mitochondrial nucleoid structure and number; mutants exhibit an increased rate of mitochondrial DNA escape; shows some sequence similarity to exonucleases mitochondrial genome maintenance molecular_function mitochondrion|integral to mitochondrial inner membrane
YJL166W YJL166W QCR8 hom Verified 1.18940916705659 0.117139347628936 no 635 0.100609332001624 336 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration ubiquinol-cytochrome-c reductase activity mitochondrion|integral to membrane|mitochondrial respiratory chain complex III
YCR047C YCR047C BUD23 hom Verified 1.18819907122735 0.11737749476665 no 636 0.11096061876598 426 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|CELL DIVISION NUCLEUS Methyltransferase, methylates residue G1575 of 18S rRNA; required for rRNA processing and nuclear export of 40S ribosomal subunits independently of methylation activity; diploid mutant displays random budding pattern endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA (guanine-N7)-methylation|cellular bud site selection|ribosomal small subunit export from nucleus S-adenosylmethionine-dependent methyltransferase activity|rRNA (guanine) methyltransferase activity nucleolus|nucleus|cytoplasm
YLR413W_p YLR413W YLR413W hom Uncharacterized 1.18529654966298 0.117950108611033 no 637 0.109874190954043 441 NA FT PLASMA MEMBRANE Putative protein of unknown function; YLR413W is not an essential gene biological_process molecular_function integral to membrane
YOR076C YOR076C SKI7 hom Verified 1.18492465243595 0.118023619639743 no 638 0.125814650438427 461 NA FT TRANSLATION|NUCLEOTIDE METABOLISM Coupling protein that mediates interactions between the Ski complex and the cytoplasmic exosome during 3'-5' RNA degradation; eRF3-like domain targets nonstop mRNA for degradation; null mutants have superkiller phenotype nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, non-stop decay|nonfunctional rRNA decay protein binding, bridging Ski complex|cytoplasmic exosome (RNase complex)|cytoplasm
YGR159C YGR159C NSR1 hom Verified 1.18311749644142 0.118381292290201 no 639 0.134530702848642 429 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS|MITOCHONDRION Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis ribosomal small subunit assembly|rRNA processing single-stranded DNA binding|RNA binding mitochondrion|nucleolus|nucleus
YGR015C_p YGR015C YGR015C hom Uncharacterized 1.18003958781732 0.118992235082236 no 640 0.132369671228273 468 NA FT MITOCHONDRION Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion biological_process molecular_function mitochondrion
YCL001W-B_p YCL001W-B YCL001W-B hom Uncharacterized 1.17944490234643 0.119110532061436 no 641 0.130967187498044 433 NA Putative protein of unknown function; present in a region duplicated between chromosomes XIV and III; YCL001W-B has a paralog, DOM34, that arose from the whole genome duplication biological_process molecular_function cellular_component
YOR202W YOR202W HIS3 hom Verified 1.1793374173768 0.119131922215665 no 642 0.0924631609208974 351 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p histidine biosynthetic process imidazoleglycerol-phosphate dehydratase activity cellular_component
YMR259C YMR259C TRM732 hom Verified 1.17802152889403 0.119394011758899 no 643 0.1299208065172 497 NA Interacts with Trm7p for 2'-O-methylation of C32 of substrate tRNAs; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; non-essential gene biological_process molecular_function cytoplasm
YIL158W YIL158W AIM20 hom Verified 1.1769404752156 0.119609632751634 no 644 0.125820291017742 460 NA FT CELL CYCLE Putative protein of unknown function; overexpression causes a cell cycle delay or arrest; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; null mutant displays elevated frequency of mitochondrial genome loss; relocalizes from nucleus to cytoplasm upon DNA replication stress biological_process molecular_function fungal-type vacuole
YBR105C YBR105C VID24 hom Verified 1.17651255336936 0.11969505951172 no 645 0.131632868847953 483 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|KETONE METABOLISM|MEMBRANE ORGANIZATION|CARBOHYDRATE METABOLISM|PROTEOLYSIS|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM GID Complex regulatory subunit; binds GID Complex in response to glucose through interactions with complex member Vid28p; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; promotes proteasome-dependent catabolite degradation of FBPase; peripheral membrane protein located at Vid (vacuole import and degradation) vesicles negative regulation of gluconeogenesis|vesicle fusion with vacuole|vacuolar protein catabolic process|proteasomal ubiquitin-dependent protein catabolic process|vesicle-mediated transport|protein targeting to vacuole molecular_function cytoplasmic membrane-bounded vesicle|GID complex|extrinsic to membrane
YLR190W YLR190W MMR1 hom Verified 1.17579793434258 0.119837816023925 no 646 0.102706909311956 402 NA FT CELL CYCLE|CELL DIVISION|MITOCHONDRION ORGANIZATION MITOCHONDRION|SITE OF POLARIZED GROWTH Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p mitochondrion inheritance molecular_function mitochondrial outer membrane|incipient cellular bud site|mitochondrion|cellular bud|cellular bud neck
YDL037C YDL037C BSC1 hom Verified 1.1748114736187 0.120035074399337 no 647 0.123890408894513 438 NA Protein of unconfirmed function, similar to cell surface flocculin Flo11p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression biological_process molecular_function cellular_component
YGL192W YGL192W IME4 hom Verified 1.17093505923095 0.120812440748361 no 648 0.144976035581388 514 NA FT CELL CYCLE NUCLEUS Probable mRNA N6-adenosine methyltransferase required for entry into meiosis; transcribed in diploid cells; haploids repress IME4 transcription via production of antisense IME4 transcripts; antisense transcription is repressed in diploids meiosis|mRNA methylation mRNA (N6-adenosine)-methyltransferase activity cellular_component
YPL167C YPL167C REV3 hom Verified 1.17060367985924 0.120879058752093 no 649 0.125837531332501 474 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION|CHROMOSOME Catalytic subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair error-prone translesion synthesis|error-free translesion synthesis DNA-directed DNA polymerase activity nuclear chromatin|mitochondrion|zeta DNA polymerase complex
YMR044W YMR044W IOC4 hom Verified 1.17050211849677 0.12089948105522 no 650 0.142726466903979 497 NA FT CHROMATIN ORGANIZATION NUCLEUS Member of a complex (Isw1b) with Isw1p and Ioc2p; interacts directly with H3K36me3 nucleosomes through its PWWP domain to recruit the Isw1b complex to open reading frames in a Set2p-dependent manner; Isw1b exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing chromatin remodeling nucleosome binding|ATPase activity|DNA binding ISW1 complex
YDL240W YDL240W LRG1 hom Verified 1.16902221190436 0.121197341178209 no 651 0.123528971291764 474 NA FT SIGNALING|CELL WALL ORG/BIOGENESIS MITOCHONDRION|SITE OF POLARIZED GROWTH Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity; appears to specifically regulate 1,3-beta-glucan synthesis fungal-type cell wall biogenesis|small GTPase mediated signal transduction Rho GTPase activator activity mitochondrion|cellular bud neck|cytoplasm
YBR289W YBR289W SNF5 hom Verified 1.1681202643993 0.121379128679547 no 652 0.127984585452187 370 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS NUCLEUS|CHROMOSOME RSC COMPLEX Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf6p; relocates to the cytosol under hypoxic conditions sucrose catabolic process|double-strand break repair via homologous recombination|chromatin remodeling|carbon catabolite activation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II activating transcription factor binding SWI/SNF complex|nucleus
YDR028C YDR028C REG1 hom Verified 1.1674049863482 0.121523429196708 no 653 0.226669387812438 791 NA FF|FT TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Regulatory subunit of type 1 protein phosphatase Glc7p; involved in negative regulation of glucose-repressible genes; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p cellular response to glucose starvation|vacuolar protein catabolic process|glycogen metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of carbohydrate metabolic process protein phosphatase type 1 regulator activity protein phosphatase type 1 complex|cytoplasm
YBR052C YBR052C RFS1 hom Verified 1.16614287113611 0.121778342913549 no 654 0.0796394967156219 355 NA FT OXIDATION-REDUCTION PROCESS Protein of unknown function; member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; RFS1 has a paralog, PST2, that arose from the whole genome duplication biological_process molecular_function membrane raft|cytoplasm
YPL098C YPL098C MGR2 hom Verified 1.1652036437085 0.121968285539952 no 655 0.142880435783769 494 NA FT MITOCHONDRION Subunit of the TIM23 translocase complex; acts to couple Tim21p with the core Tim23 translocase; absolutely required for mitochondrial import of presequence-containing proteins at elevated temperature; required for viability of cells lacking the mitochondrial genome (petite-negative phenotype) protein import into mitochondrial matrix molecular_function mitochondrial inner membrane presequence translocase complex
YNL070W YNL070W TOM7 hom Verified 1.16273529931165 0.1224684575262 no 656 0.14078115001322 546 NA FF|FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex protein import into mitochondrial matrix|protein import into mitochondrial outer membrane protein channel activity mitochondrial outer membrane|mitochondrion|integral to membrane|mitochondrial outer membrane translocase complex
YOL031C YOL031C SIL1 hom Verified 1.16163441440202 0.122691998396547 no 657 0.110519252067234 472 NA FT PROTEIN LOCALIZATION ENDOPLASMIC RETICULUM Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, required for protein translocation into the ER; homolog of Yarrowia lipolytica SLS1; GrpE-like protein SRP-dependent cotranslational protein targeting to membrane, translocation adenyl-nucleotide exchange factor activity endoplasmic reticulum
YGL229C YGL229C SAP4 hom Verified 1.16156461328627 0.12270618154805 no 658 0.125268688059127 428 NA FT CELL CYCLE MITOCHONDRION Protein required for function of the Sit4p protein phosphatase, member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p G1/S transition of mitotic cell cycle protein serine/threonine phosphatase activity mitochondrion|cytoplasm
YCR017C YCR017C CWH43 hom Verified 1.16115145598523 0.122790156085023 no 659 0.162061892805716 576 NA FT LIPID METABOLISM|CELL WALL ORG/BIOGENESIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Putative sensor/transporter protein involved in cell wall biogenesis; contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites; null mutation is synthetically lethal with pkc1 deletion fungal-type cell wall organization|GPI anchor biosynthetic process molecular_function integral to membrane|integral to plasma membrane|cellular bud neck|cellular bud tip
YHR177W_p YHR177W YHR177W hom Uncharacterized 1.16027060504661 0.12296932425212 no 660 0.12476966478615 465 NA Putative protein of unknown function; overexpression causes a cell cycle delay or arrest biological_process molecular_function cellular_component
YHR026W YHR026W VMA16 hom Verified 1.16005436483371 0.123013336275633 no 661 0.219916406594569 721 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS Subunit c'' of the vacuolar ATPase, which functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domain vacuolar acidification proton-transporting ATPase activity, rotational mechanism vacuolar proton-transporting V-type ATPase, V0 domain|integral to membrane
YJL169W_d YJL169W YJL169W hom Dubious 1.15951571113001 0.123123018102233 no 662 0.113443801751638 421 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2 Unknown Unknown Unknown
YPL264C_p YPL264C YPL264C hom Uncharacterized 1.15930676258051 0.123165583101681 no 663 0.108188902781444 374 NA Putative membrane protein of unknown function; physically interacts with Hsp82p; YPL264C is not an essential gene biological_process molecular_function integral to membrane
YDR246W-A_p YDR246W-A YDR246W-A hom Uncharacterized 1.15862745863729 0.123304035663452 no 664 0.108875927293703 425 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YHR134W YHR134W WSS1 hom Verified 1.15794799437901 0.123442629951878 no 665 0.0854722596913725 398 NA FT RESPONSE TO DNA DAMAGE ENDOMEMBRANE SYSTEM|NUCLEUS Sumoylated protein that localizes to a single spot on the nuclear periphery of mother cells but not daughters; interacts genetically with SMT3; UV-sensitive mutant phenotype and genetic interactions suggest a role in the DNA damage response protein sumoylation|response to UV-B|response to UV-C|response to DNA damage stimulus molecular_function nuclear envelope
YFL041W-A_p YFL041W-A YFL041W-A hom Uncharacterized 1.15660800733147 0.123716274647454 no 666 0.123975306667319 436 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YDL074C YDL074C BRE1 hom Verified 1.15481102015966 0.124083911640712 no 667 0.192985663739166 648 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING NUCLEUS|CHROMOSOME E3 ubiquitin ligase, forms heterodimer with Rad6p to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR, transcription, silencing, and checkpoint control mitotic cell cycle G1/S transition DNA damage checkpoint|intra-S DNA damage checkpoint|meiotic DNA double-strand break formation|histone monoubiquitination|double-strand break repair via homologous recombination|transcription from RNA polymerase II promoter|chromatin silencing at telomere ubiquitin-protein ligase activity nuclear chromatin
YLR296W_d YLR296W YLR296W hom Dubious 1.15320141171488 0.124413862111872 no 668 0.122912342844837 463 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YIL014C-A_p YIL014C-A YIL014C-A hom Uncharacterized 1.15067378865219 0.124933231871437 no 669 0.140438859007649 497 NA Putative protein of unknown function biological_process molecular_function cellular_component
YPL049C YPL049C DIG1 hom Verified 1.15019063678069 0.1250326809132 no 670 0.149365146877631 550 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p negative regulation of transcription from RNA polymerase II promoter by pheromones|Unknown DNA binding|transcription factor binding nucleus
YLR437C YLR437C DIF1 hom Verified 1.1500903059084 0.125053339341002 no 671 0.105133898759191 405 NA FT NUCLEUS Protein that regulates the nuclear localization of ribonucleotide reductase Rnr2p and Rnr4p subunits; phosphorylated by Dun1p in response to DNA damage and degraded; N-terminal half has similarity to S. pombe Spd1 protein biological_process molecular_function cytoplasm
YOR379C_d YOR379C YOR379C hom Dubious 1.14865585233172 0.125348958360702 no 672 0.117050355198812 434 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR378W Unknown Unknown Unknown
YPR068C YPR068C HOS1 hom Verified 1.14813070722491 0.125457304655009 no 673 0.10082676947433 421 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS Class I histone deacetylase (HDAC) family member that deacetylates Smc3p on lysine residues at anaphase onset; has sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; interacts with the Tup1p-Ssn6p corepressor complex peptidyl-lysine deacetylation|histone H4 deacetylation|positive regulation of transcription from RNA polymerase II promoter histone deacetylase activity|protein deacetylase activity histone deacetylase complex
YKL181W YKL181W PRS1 hom Verified 1.14780096415603 0.125525369609362 no 674 0.124456606424973 491 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes fungal-type cell wall organization|5-phosphoribose 1-diphosphate biosynthetic process ribose phosphate diphosphokinase activity cytoplasm
YKR040C_d YKR040C YKR040C hom Dubious 1.14660194325794 0.125773086489706 no 675 0.116523403877219 430 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YKR041W Unknown Unknown Unknown
YHR067W YHR067W HTD2 hom Verified 1.14558780861385 0.125982872016602 no 676 0.159626016551841 582 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION Mitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology fatty acid biosynthetic process 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity mitochondrion
YKL092C YKL092C BUD2 hom Verified 1.14545224231842 0.126010933956003 no 677 0.117958802626043 409 NA FT CELL CYCLE|SIGNALING|CELL DIVISION|NUCLEOTIDE METABOLISM PLASMA MEMBRANE GTPase activating factor for Rsr1p/Bud1p; required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types; mutant deficient in mitotic spindle position checkpoint bipolar cellular bud site selection|small GTPase mediated signal transduction|filamentous growth|cellular bud site selection|axial cellular bud site selection GTPase activator activity|Ras GTPase activator activity intracellular
YDL101C YDL101C DUN1 hom Verified 1.14355505190564 0.126404105712089 no 678 0.140224140110696 553 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION NUCLEUS Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; also regulates postreplicative DNA repair protein phosphorylation|replication fork protection|cell cycle checkpoint|DNA damage checkpoint protein kinase activity nucleus
YOL050C_d YOL050C YOL050C hom Dubious 1.14293185961584 0.12653344172831 no 679 0.145277778044341 529 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) Unknown Unknown Unknown
YNL233W YNL233W BNI4 hom Verified 1.14214441079445 0.126696998990972 no 680 0.162017129575614 574 NA FT PROTEIN LOCALIZATION|CELL DIVISION|CARBOHYDRATE METABOLISM SITE OF POLARIZED GROWTH|CYTOSKELETON Targeting subunit for Glc7p protein phosphatase, localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p asymmetric protein localization|barrier septum assembly|chitin biosynthetic process protein binding incipient cellular bud site|cellular bud neck septin collar|cellular bud neck|septin ring
YER046W YER046W SPO73 hom Verified 1.141748542853 0.12677927843151 no 681 0.115404949598207 384 NA FT CELL WALL ORG/BIOGENESIS Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis ascospore wall assembly|ascospore formation molecular_function cytosol
YEL022W YEL022W GEA2 hom Verified 1.14132642418054 0.126867054952024 no 682 0.165389638350457 573 NA FT VESICLE-MEDIATED TRANSPORT|SIGNALING|CYTOSKELETON ORGANIZATION|RESPONSE TO NUTRIENT LEVELS GOLGI APPARATUS Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA2 has a paralog, GEA1, that arose from the whole genome duplication retrograde vesicle-mediated transport, Golgi to ER|secretory granule organization|ER to Golgi vesicle-mediated transport|macroautophagy|intra-Golgi vesicle-mediated transport|actin cytoskeleton organization ARF guanyl-nucleotide exchange factor activity integral to membrane|Golgi cis cisterna|extrinsic to membrane
YGR162W YGR162W TIF4631 hom Verified 1.14070307228267 0.126996753817923 no 683 0.141112276476695 526 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION MITOCHONDRION RIBOSOME Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication translational initiation|ribosomal large subunit biogenesis|stress granule assembly translation initiation factor activity mitochondrion|ribosome|eukaryotic translation initiation factor 4F complex|cytoplasmic stress granule
YPL108W_p YPL108W YPL108W hom Uncharacterized 1.13946810582677 0.127253981855739 no 684 0.139637154672895 487 NA Cytoplasmic protein of unknown function; non-essential gene that is induced in a GDH1 deleted strain with altered redox metabolism; GFP-fusion protein is induced in response to the DNA-damaging agent MMS biological_process molecular_function cytoplasm
YOR096W YOR096W RPS7A hom Verified 1.13811265940771 0.127536721322469 no 685 0.162491821905795 542 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION NUCLEUS RIBOSOME Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7A has a paralog, RPS7B, that arose from the whole genome duplication cytoplasmic translation|ribosome biogenesis structural constituent of ribosome small-subunit processome|cytosolic small ribosomal subunit|90S preribosome
YLR251W YLR251W SYM1 hom Verified 1.13725570123378 0.127715703805504 no 686 0.114988422240669 383 NA FT MITOCHONDRION Protein required for ethanol metabolism; induced by heat shock and localized to the inner mitochondrial membrane; homologous to mammalian peroxisomal membrane protein Mpv17 ethanol metabolic process molecular_function mitochondrion|integral to membrane|mitochondrial inner membrane
YGL056C YGL056C SDS23 hom Verified 1.1371693273249 0.127733753359323 no 687 0.130374455742664 492 NA FT CELL DIVISION NUCLEUS One of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; involved in cell separation during budding; SDS23 has a paralog, SDS24, that arose from the whole genome duplication cytokinetic cell separation molecular_function nucleus|cytoplasm
YOL014W_p YOL014W YOL014W hom Uncharacterized 1.13632139859132 0.127911039148239 no 688 0.150627616674447 522 NA Putative protein of unknown function biological_process molecular_function cellular_component
YCR033W YCR033W SNT1 hom Verified 1.13412867121926 0.128370289278644 no 689 0.132345418955596 463 NA FT CELL CYCLE|CHROMATIN ORGANIZATION|SIGNALING NUCLEUS|CHROMOSOME Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein; mutant has increased aneuploidy tolerance negative regulation of meiosis|regulation of transcription, DNA-dependent|histone deacetylation|positive regulation of stress-activated MAPK cascade molecular_function Rpd3L-Expanded complex|Set3 complex
YBL021C YBL021C HAP3 hom Verified 1.13215081369381 0.128785517439815 no 690 0.135830624753175 405 NA FT TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding carbon catabolite activation of transcription from RNA polymerase II promoter|regulation of cellular respiration RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription CCAAT-binding factor complex
YNL144C_p YNL144C YNL144C hom Uncharacterized 1.13124513841843 0.128975964098411 no 691 0.117198108217772 424 NA FT MITOCHONDRION Putative protein of unknown function; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; contains a PH domain and binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study biological_process molecular_function mitochondrion
YER086W YER086W ILV1 hom Verified 1.12864676128066 0.129523438097992 no 692 0.162954777024408 581 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation threonine catabolic process|isoleucine biosynthetic process L-threonine ammonia-lyase activity mitochondrion
YGR263C YGR263C SAY1 hom Verified 1.12784413656292 0.129692874870225 no 693 0.137954566868367 462 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Sterol deacetylase; component of the sterol acetylation/deacetylation cycle along with Atf2p; integral membrane protein with active site in the ER lumen; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum response to toxin|sterol metabolic process|sterol deacetylation steryl deacetylase activity integral to membrane|endoplasmic reticulum|endoplasmic reticulum lumen
YDR440W YDR440W DOT1 hom Verified 1.12582837278444 0.130119086066363 no 694 0.132395328876019 459 NA FT CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING NUCLEUS Nucleosomal histone H3-Lys79 methylase; methylation is required for telomeric silencing, meiotic checkpoint control, and DNA damage response meiotic recombination checkpoint|postreplication repair|recombinational repair|global genome nucleotide-excision repair|nucleotide-excision repair|DNA damage checkpoint|chromatin silencing at telomere|histone H3-K79 methylation nucleosomal histone binding|histone methyltransferase activity (H3-K79 specific) nucleus
YMR219W YMR219W ESC1 hom Verified 1.12524382263823 0.130242863899147 no 695 0.143842208749334 504 NA FT GENE SILENCING NUCLEUS Protein localized to the nuclear periphery, involved in telomeric silencing; interacts with PAD4-domain of Sir4p chromatin silencing at telomere molecular_function nuclear periphery
YOL067C YOL067C RTG1 hom Verified 1.12372477336574 0.130564901709953 no 696 0.159179780626475 544 NA FT TRANSCRIPTION FROM RNA POL II|SIGNALING NUCLEUS Transcription factor (bHLH) involved in interorganelle communication between mitochondria, peroxisomes, and nucleus cellular response to oleic acid|positive regulation of transcription from RNA polymerase II promoter|mitochondria-nucleus signaling pathway sequence-specific DNA binding RNA polymerase II transcription factor activity nucleus|cytoplasm
YMR163C YMR163C INP2 hom Verified 1.12283172001643 0.130754485442342 no 697 0.119723907612923 462 NA FT PEROXISOME ORGANIZATION Peroxisome-specific receptor important for peroxisome inheritance; co-fractionates with peroxisome membranes and co-localizes with peroxisomes in vivo; physically interacts with the myosin V motor Myo2p; INP2 is not an essential gene peroxisome inheritance protein anchor peroxisome|integral to peroxisomal membrane|cytoplasm
YGL232W YGL232W TAN1 hom Verified 1.12056799740757 0.131235896812805 no 698 0.136757933867958 465 NA FT RNA PROCESSING NUCLEUS Putative tRNA acetyltransferase; RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA; protein abundance increases in response to DNA replication stress tRNA modification RNA binding nucleus|cytoplasm
YNR055C YNR055C HOL1 hom Verified 1.12048526188908 0.131253514802094 no 699 0.120009072259466 447 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION|PLASMA MEMBRANE Putative transporter in the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; mutations in membrane-spanning domains permit cation and histidinol uptake organic alcohol transport|cation transport alcohol transmembrane transporter activity|inorganic cation transmembrane transporter activity mitochondrion|integral to membrane|plasma membrane
YGR287C YGR287C IMA1 hom Verified 1.11946073951458 0.131471815513773 no 700 0.130394859885104 482 NA FT CARBOHYDRATE METABOLISM MITOCHONDRION Major isomaltase (alpha-1,6-glucosidase/alpha-methylglucosidase); required for isomaltose utilization; specificity for isomaltose, alpha-methylglucoside, and palatinose; member of the IMA isomaltase family disaccharide catabolic process oligo-1,6-glucosidase activity mitochondrion|ribosome
YFR055W_p YFR055W IRC7 hom Uncharacterized 1.11641974446101 0.132121252902199 no 701 0.137922220126676 489 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Beta-lyase involved in the production of thiols; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner and by copper levels in a Mac1-dependent manner sulfur compound metabolic process|L-cysteine catabolic process to pyruvate cysteine-S-conjugate beta-lyase activity cellular_component
YNL196C_p YNL196C SLZ1 hom Uncharacterized 1.11516869760983 0.132389068606027 no 702 0.142288836169695 554 NA Sporulation-specific protein with a leucine zipper motif biological_process molecular_function cellular_component
YHL019C YHL019C APM2 hom Verified 1.11411353372674 0.132615241662518 no 703 0.121688972056041 474 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport Golgi to vacuole transport|vesicle-mediated transport clathrin binding AP-1 adaptor complex
YJL068C YJL068C YJL068C hom Verified 1.11395641276677 0.132648943098954 no 704 0.113946540398801 426 NA Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D formaldehyde catabolic process S-formylglutathione hydrolase activity cytosol
YCR087W_d YCR087W YCR087W hom Dubious 1.11039659477169 0.133414082470066 no 705 0.152205128130455 531 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YCR087C-A; YCR087W is not an essential gene Unknown Unknown Unknown
YOL030W YOL030W GAS5 hom Verified 1.11031210429805 0.133432279472264 no 706 0.129783980201514 476 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM 1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall (1->3)-beta-D-glucan metabolic process 1,3-beta-glucanosyltransferase activity fungal-type cell wall|integral to membrane
YPR197C_d YPR197C YPR197C hom Dubious 1.11011746619244 0.133474205842832 no 707 0.200432654069069 711 NA FF Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR317W YDR317W HIM1 hom Verified 1.10870110801817 0.133779571884345 no 708 0.11307148887702 420 NA FT RESPONSE TO DNA DAMAGE Protein of unknown function involved in DNA repair DNA repair molecular_function cellular_component
YLL040C YLL040C VPS13 hom Verified 1.10850451429305 0.133821995308278 no 709 0.131886052769221 481 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT MITOCHONDRION|GOLGI APPARATUS Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; involved in sporulation, vacuolar protein sorting, prospore membrane formation and protein-Golgi retention; homologous to human CHAC and COH1 which are involved in chorea acanthocytosis and Cohen syndrome, respectively protein retention in Golgi apparatus|late endosome to vacuole transport|protein targeting to vacuole|ascospore-type prospore membrane assembly molecular_function endosome|mitochondrion|prospore membrane|extrinsic to membrane
YKL139W YKL139W CTK1 hom Verified 1.10724571500461 0.134093853736657 no 710 0.160454011662712 543 NA FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|RESPONSE TO DNA DAMAGE|TRANSLATION|PROTEIN PHOSPHORYLATION NUCLEUS Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I); phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity; similar to the Drosophila dCDK12 and human CDK12 and probably CDK13 mRNA 3'-end processing|phosphorylation of RNA polymerase II C-terminal domain|positive regulation of translational fidelity|positive regulation of transcription from RNA polymerase I promoter|peptidyl-serine phosphorylation|positive regulation of DNA-dependent transcription, elongation|protein phosphorylation protein kinase activity|cyclin-dependent protein kinase activity nucleoplasm|nucleolus|nucleus|polysome|carboxy-terminal domain protein kinase complex
YBR063C_p YBR063C YBR063C hom Uncharacterized 1.10705379320944 0.13413533571808 no 711 0.118467509411571 447 NA Putative protein of unknown function; YBR063C is not an essential gene biological_process molecular_function cellular_component
YNL293W YNL293W MSB3 hom Verified 1.10517273714132 0.134542373844806 no 712 0.135476042156967 457 NA FT VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH Rab GTPase-activating protein; regulates endocytosis via activation of Vps21p and Ypt7p; also acts on Ypt52p and Sec4p; also required for proper actin organization; localizes to the plasma membrane and sites of polarized growth, and a portion localizes to endosomes and vacuoles; similar to Msb4p; relocalizes from bud neck to cytoplasm upon DNA replication stress actin filament organization|exocytosis Rab GTPase activator activity incipient cellular bud site|polarisome|cellular bud tip
YEL012W YEL012W UBC8 hom Verified 1.10410879910324 0.13477297238958 no 713 0.132560520021273 469 NA FT KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein polyubiquitination|protein monoubiquitination ubiquitin-protein ligase activity cytoplasm
YDL129W YDL129W YDL129W hom Verified 1.10339803784121 0.134927174209388 no 714 0.0962090876904448 326 NA FT NUCLEUS Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YDL129W is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress biological_process molecular_function nucleus|cytoplasm
YDR291W YDR291W HRQ1 hom Verified 1.10294643879586 0.135025212850037 no 715 0.12356123452145 440 NA FT NUCLEUS 3'-5'DNA helicase that has DNA strand annealing activity; helicase activity is stimulated by fork structure and 3'-tail length of substrates; belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity; similar to the human RecQ4p implicated in Rothmund-Thomson syndrome(RTS) biological_process molecular_function nucleus
YJR120W YJR120W YJR120W hom Verified 1.1019554517656 0.13524051962662 no 716 0.132945007906528 473 NA FT OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p cellular respiration|sterol transport|mitochondrion organization molecular_function cellular_component
YDL006W YDL006W PTC1 hom Verified 1.10154646899232 0.135329445835754 no 717 0.210793779907396 761 NA FF|FT RNA PROCESSING|SIGNALING|MITOCHONDRION ORGANIZATION|PROTEIN PHOSPHORYLATION NUCLEUS Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p, inactivating osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing, mitochondrial inheritance, and sporulation mitochondrion inheritance|inactivation of MAPK activity involved in osmosensory signaling pathway|pheromone-dependent signal transduction involved in conjugation with cellular fusion|tRNA splicing, via endonucleolytic cleavage and ligation|protein dephosphorylation protein serine/threonine phosphatase activity nucleus|cytoplasm
YGL090W YGL090W LIF1 hom Verified 1.10136452232644 0.135369019860495 no 718 0.137814085073239 529 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein double-strand break repair via nonhomologous end joining chromatin binding DNA ligase IV complex|nuclear chromatin|nucleus
YOL001W YOL001W PHO80 hom Verified 1.10080457827438 0.135490859377915 no 719 0.169106131873803 655 NA FF|FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CELL CYCLE|SIGNALING|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS|RESPONSE TO NUTRIENT LEVELS NUCLEUS Cyclin, interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling negative regulation of phosphate metabolic process|regulation of cyclin-dependent protein kinase activity|negative regulation of calcium-mediated signaling|negative regulation of transcription from RNA polymerase II promoter|cellular metal ion homeostasis|regulation of protein localization|negative regulation of macroautophagy cyclin-dependent protein kinase regulator activity cyclin-dependent protein kinase holoenzyme complex|nucleus
YOL117W YOL117W RRI2 hom Verified 1.10041679318493 0.135575282457613 no 720 0.133260897310866 502 NA FT SIGNALING NUCLEUS Subunit of the COP9 signalosome (CSN) complex that cleaves the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; plays a role in the mating pheromone response adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|cullin deneddylation molecular_function signalosome
YLR220W YLR220W CCC1 hom Verified 1.09903458013633 0.13587649144756 no 721 0.12630660590279 473 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Putative vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack the ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation; relative distribution to the vacuole decreases upon DNA replication stress manganese ion transport|cellular calcium ion homeostasis|cellular iron ion homeostasis|cellular manganese ion homeostasis|ferrous iron transport manganese ion transmembrane transporter activity|ferrous iron transmembrane transporter activity fungal-type vacuole membrane|integral to membrane|Golgi apparatus
YLR273C YLR273C PIG1 hom Verified 1.09902958197999 0.135877581466226 no 722 0.100417438629911 419 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Putative targeting subunit for the type-1 protein phosphatase Glc7p that tethers it to the Gsy2p glycogen synthase regulation of glycogen biosynthetic process protein phosphatase type 1 regulator activity protein phosphatase type 1 complex
YJR092W YJR092W BUD4 hom Verified 1.09842451284094 0.136009581692732 no 723 0.119018164158379 405 NA FT CELL CYCLE|CELL DIVISION SITE OF POLARIZED GROWTH|CYTOSKELETON Anillin-like protein involved in bud-site selection; required for the axial budding pattern; localizes with septins to the bud neck in mitosis and may constitute an axial landmark for the next round of budding; required for the formation and disassembly of the double septin ring structure, and generally for septin organization; in vivo substrate of Cdc28p/Clb2p cellular bud site selection|axial cellular bud site selection GTP binding cellular bud neck contractile ring
YLR231C YLR231C BNA5 hom Verified 1.0983513168584 0.136025555877977 no 724 0.10613522831762 410 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM NUCLEUS Kynureninase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p de novo NAD biosynthetic process from tryptophan kynureninase activity nucleus|cytoplasm
YPL203W YPL203W TPK2 hom Verified 1.09826146415961 0.1360451669568 no 725 0.132391101237374 518 NA FT SIGNALING|PROTEIN PHOSPHORYLATION NUCLEUS cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk3p; localizes to P-bodies during stationary phase protein phosphorylation|Ras protein signal transduction|invasive growth in response to glucose limitation cAMP-dependent protein kinase activity|protein kinase activity nucleus|cAMP-dependent protein kinase complex
YBR042C YBR042C CST26 hom Verified 1.09745401773743 0.136221485517925 no 726 0.126331803022032 500 NA FT LIPID METABOLISM Putative transferase involved in phospholipid biosynthesis; required for incorporation of stearic acid into phosphatidylinositol; affects chromosome stability when overexpressed; CST26 has a paralog, YDR018C, that arose from the whole genome duplication phospholipid biosynthetic process transferase activity, transferring acyl groups lipid particle
YPR149W YPR149W NCE102 hom Verified 1.09696685744038 0.136327940193979 no 727 0.120625842378703 467 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION ENDOPLASMIC RETICULUM|MITOCHONDRION|PLASMA MEMBRANE Protein of unknown function; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs) eisosome assembly|protein secretion|negative regulation of protein phosphorylation|plasma membrane organization|establishment of protein localization to plasma membrane molecular_function mitochondrion|integral to membrane|membrane raft|endoplasmic reticulum|cellular bud membrane|plasma membrane|mating projection membrane|cytoplasm
YOR230W YOR230W WTM1 hom Verified 1.09564705117079 0.136616631292081 no 728 0.133468418819046 448 NA FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CELL CYCLE|GENE SILENCING NUCLEUS Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; required for nuclear localization of the ribonucleotide reductase small subunit Rnr2p and Rnr4p; contains WD repeats negative regulation of chromatin silencing at silent mating-type cassette|maintenance of protein location in nucleus|negative regulation of transcription from RNA polymerase II promoter during meiosis|negative regulation of chromatin silencing at telomere|protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter protein binding|transcription corepressor activity nucleus
YJL152W_d YJL152W YJL152W hom Dubious 1.09449803445574 0.136868304478353 no 729 0.0709783047478006 300 NA Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPL138C YPL138C SPP1 hom Verified 1.09334436506093 0.137121315386189 no 730 0.141766539858716 502 NA FT CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS Subunit of COMPASS (Set1C), a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; interacts with Orc2p; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein histone H3-K4 methylation|regulation of transcription, DNA-dependent|chromatin silencing at telomere histone methyltransferase activity (H3-K4 specific)|chromatin binding|methylated histone residue binding Set1C/COMPASS complex
YOR242C YOR242C SSP2 hom Verified 1.09309825894672 0.137175330173614 no 731 0.11592349500748 429 NA FT CELL WALL ORG/BIOGENESIS Sporulation specific protein that localizes to the spore wall; required for sporulation at a point after meiosis II and during spore wall formation; SSP2 expression is induced midway in meiosis ascospore wall assembly|ascospore formation molecular_function ascospore wall
YBR294W YBR294W SUL1 hom Verified 1.09127163444762 0.137576687661554 no 732 0.107147658948812 412 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE High affinity sulfate permease of the SulP anion transporter family; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates sulfate transport|transmembrane transport sulfate transmembrane transporter activity integral to membrane|plasma membrane
YKR001C YKR001C VPS1 hom Verified 1.08805552267087 0.138285298562772 no 733 0.233629752270843 765 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION|VACUOLAR TRANSPORT|PEROXISOME ORGANIZATION MITOCHONDRION|CYTOSKELETON Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, endocytosis, late Golgi-retention of some proteins, regulation of peroxisome biogenesis vacuolar transport|peroxisome fission|endocytosis|actin cytoskeleton organization|protein retention in Golgi apparatus|peroxisome organization|lipid tube assembly|protein targeting to vacuole GTPase activity mitochondrial outer membrane|fungal-type vacuole membrane|peroxisome|actin cortical patch
YPL091W YPL091W GLR1 hom Verified 1.08567450472028 0.138811512111316 no 734 0.153655332281324 596 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS NUCLEUS|MITOCHONDRION Cytosolic and mitochondrial glutathione oxidoreductase; converts oxidized glutathione to reduced glutathione; mitochondrial but not cytosolic form has a role in resistance to hyperoxia; protein abundance increases in response to DNA replication stress cellular response to oxidative stress|protein glutathionylation glutathione-disulfide reductase activity mitochondrion|nucleus|cytoplasm
YJR036C YJR036C HUL4 hom Verified 1.08543275361545 0.138865016133429 no 735 0.143307464328839 496 NA FT PROTEOLYSIS NUCLEUS Protein with similarity to hect domain E3 ubiquitin-protein ligases; not essential for viability; found in association with Trf4 in TRAMP complex protein ubiquitination ubiquitin-protein ligase activity TRAMP complex
YIR033W YIR033W MGA2 hom Verified 1.08535326669993 0.138882611135651 no 736 0.113851596565938 396 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|GENE SILENCING ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting positive regulation of transcription from RNA polymerase II promoter in response to hypoxia|cellular response to cold|positive regulation of unsaturated fatty acid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|mRNA stabilization|positive regulation of transcription from RNA polymerase II promoter in response to cobalt ion|positive regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette molecular_function integral to endoplasmic reticulum membrane|nucleus
YKL062W YKL062W MSN4 hom Verified 1.08521081324085 0.138914148034656 no 737 0.133259327132581 469 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|RESPONSE TO OXIDATIVE STRESS NUCLEUS Transcriptional activator; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression; MSN4 has a paralog, MSN2, that arose from the whole genome duplication positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription from RNA polymerase II promoter in response to a hypotonic environment|positive regulation of transcription from RNA polymerase II promoter in response to alkalinity|positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation|positive regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation|positive regulation of transcription from RNA polymerase II promoter in response to acidity|chromatin remodeling|regulation of replicative cell aging by regulation of transcription from RNA polymerase II promoter in response to caloric restriction|positive regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide|positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance|positive regulation of transcription from RNA polymerase II promoter in response to increased salt|cellular response to acidity|positive regulation of transcription from RNA polymerase II promoter in response to freezing|positive regulation of transcription from RNA polymerase II promoter in response to ethanol|replicative cell aging|age-dependent response to oxidative stress involved in chronological cell aging|positive regulation of transcription from RNA polymerase II promoter in response to hydrostatic pressure|positive regulation of transcription from RNA polymerase II promoter in response to nitrosative stress|positive regulation of transcription from RNA polymerase II promoter in response to cold|positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding cytosol|nucleus
YPR073C YPR073C LTP1 hom Verified 1.08429120382724 0.13911785206877 no 738 0.123313754395988 470 NA FT NUCLEUS Protein phosphotyrosine phosphatase of unknown cellular role; activated by adenine protein dephosphorylation protein tyrosine phosphatase activity nucleus|cytoplasm
YPL039W_p YPL039W YPL039W hom Uncharacterized 1.08337516188112 0.13932096790642 no 739 0.155365089613683 561 NA Putative protein of unknown function; YPL039W is not an essential gene biological_process molecular_function cellular_component
YIL071C YIL071C PCI8 hom Verified 1.08260731025889 0.139491380578209 no 740 0.152135523920486 543 NA FT NUCLEUS Possible shared subunit of Cop9 signalosome (CSN) and eIF3, binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain cullin deneddylation molecular_function signalosome
YBL058W YBL058W SHP1 hom Verified 1.08179448696098 0.139671928424529 no 741 0.118570721935442 375 NA FT PROTEIN LOCALIZATION|CELL CYCLE|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEOLYSIS|CYTOSKELETON ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY|CHROMOSOME SEGREGATION NUCLEUS UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p; interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate glycogen metabolic process|proteasomal ubiquitin-dependent protein catabolic process|piecemeal microautophagy of nucleus|ER-associated protein catabolic process|ascospore formation|sister chromatid biorientation|autophagic vacuole assembly protein phosphatase type 1 regulator activity nucleus|cytoplasm
YMR202W YMR202W ERG2 hom Verified 1.08109255727677 0.139827971900194 no 742 0.273035606396376 1000 NA FF|FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis ergosterol biosynthetic process C-8 sterol isomerase activity endoplasmic reticulum
YAL066W_d YAL066W YAL066W hom Dubious 1.07771606005674 0.140580244561781 no 743 0.163614181112502 492 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YFL025C YFL025C BST1 hom Verified 1.07677623090267 0.140790123305162 no 744 0.219196392408667 751 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|PROTEOLYSIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules protein retention in ER lumen|vesicle organization|ER-associated protein catabolic process|ER to Golgi vesicle-mediated transport|GPI anchor metabolic process phosphatidylinositol deacylase activity integral to membrane|endoplasmic reticulum
YDR306C_p YDR306C YDR306C hom Uncharacterized 1.07643230603087 0.140866980288051 no 745 0.158597434045968 534 NA FT PROTEOLYSIS F-box protein of unknown function; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity|protein binding, bridging SCF ubiquitin ligase complex
YNL281W YNL281W HCH1 hom Verified 1.07417559857943 0.141371993380777 no 746 0.105844305479912 399 NA FT NUCLEOTIDE METABOLISM NUCLEUS Heat shock protein regulator; binds to Hsp90p and may stimulate ATPase activity; originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation; GFP-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress protein folding|response to stress ATPase activator activity|chaperone binding nucleus|cytoplasm
YER145C YER145C FTR1 hom Verified 1.07309230049014 0.141614852616497 no 747 0.151391083506958 602 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE High affinity iron permease; involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron; protein abundance increases in response to DNA replication stress iron assimilation by reduction and transport|high-affinity iron ion transport|transmembrane transport iron ion transmembrane transporter activity high affinity iron permease complex|integral to membrane|plasma membrane
YKL096C-B_p YKL096C-B YKL096C-B hom Uncharacterized 1.07231070686855 0.14179024964747 no 748 0.159251888082139 517 NA Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YMR143W YMR143W RPS16A hom Verified 1.07148520898237 0.141975658899994 no 749 0.14245544302555 488 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16A has a paralog, RPS16B, that arose from the whole genome duplication cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit|90S preribosome
YPL261C_d YPL261C YPL261C hom Dubious 1.07127108571187 0.142023778413418 no 750 0.137583056193142 546 NA Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YPL260W Unknown Unknown Unknown
YPL074W YPL074W YTA6 hom Verified 1.07071434062495 0.142148946340752 no 751 0.0965347434406046 396 NA Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family; localized to the cortex of mother cells but not to daughter cells; relocalizes from cytoplasm to plasma membrane foci upon DNA replication stress biological_process ATPase activity cell cortex
YLR388W YLR388W RPS29A hom Verified 1.06895585580573 0.142544780659146 no 752 0.189592972677799 668 NA FT TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29A has a paralog, RPS29B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic small ribosomal subunit
YOR303W YOR303W CPA1 hom Verified 1.06857159106911 0.142631377666055 no 753 0.124533196807302 398 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Small subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader arginine biosynthetic process carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity carbamoyl-phosphate synthase complex
YIL057C YIL057C RGI2 hom Verified 1.06750457740911 0.142872023877411 no 754 0.159256723829704 567 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY Protein of unknown function involved in energy metabolism under respiratory conditions; expression induced under carbon limitation and repressed under high glucose energy reserve metabolic process molecular_function cytoplasm
YDR352W YDR352W YPQ2 hom Verified 1.06439445330454 0.14357502272072 no 755 0.115912306339452 402 NA Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; mutant phenotype is functionally complemented by rat PQLC2 vacuolar transporter biological_process molecular_function fungal-type vacuole membrane|integral to membrane
YJL077W-B_p YJL077W-B YJL077W-B hom Uncharacterized 1.06260261561343 0.14398110018219 no 756 0.18743034168646 592 NA Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YBR220C_p YBR220C YBR220C hom Uncharacterized 1.06116703994657 0.144306997707804 no 757 0.14051326854775 484 NA Putative protein of unknown function; YBR220C is not an essential gene biological_process molecular_function integral to membrane
YKL087C YKL087C CYT2 hom Verified 1.06080664178041 0.144388891596307 no 758 0.144686628220525 499 NA FT PROTEIN COMPLEX ORG/BIOGENESIS MITOCHONDRION Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1 cytochrome c-heme linkage holocytochrome-c synthase activity mitochondrion|mitochondrial intermembrane space
YBL022C YBL022C PIM1 hom Verified 1.05932597535726 0.144725674574115 no 759 0.190683826856078 650 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION|RESPONSE TO OXIDATIVE STRESS MITOCHONDRION ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria chaperone-mediated protein complex assembly|misfolded or incompletely synthesized protein catabolic process ATP-dependent peptidase activity mitochondrion|mitochondrial matrix
YOR323C YOR323C PRO2 hom Verified 1.05858965294049 0.144893350605409 no 760 0.247561102858018 913 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS NUCLEUS Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis proline biosynthetic process glutamate-5-semialdehyde dehydrogenase activity nucleus|cytoplasm
YNL203C_d YNL203C YNL203C hom Dubious 1.05850815481479 0.144911917471484 no 761 0.150309438703689 587 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YNL170W_d YNL170W YNL170W hom Dubious 1.05708544876463 0.145236295777598 no 762 0.159352302552171 596 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPL089C YPL089C RLM1 hom Verified 1.05689827113435 0.145279008790751 no 763 0.181703772584758 582 NA FT TRANSCRIPTION FROM RNA POL II|SIGNALING NUCLEUS MADS-box transcription factor; component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p; RLM1 has a paralog, SMP1, that arose from the whole genome duplication signal transduction|positive regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|DNA binding, bending|sequence-specific DNA binding nucleus
YKL093W YKL093W MBR1 hom Verified 1.05573583094818 0.145544461127123 no 764 0.136299280825294 515 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants aerobic respiration molecular_function cellular_component
YMR256C YMR256C COX7 hom Verified 1.05474527382361 0.145770919851654 no 765 0.175729480695808 607 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain mitochondrial electron transport, cytochrome c to oxygen cytochrome-c oxidase activity mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YPR156C YPR156C TPO3 hom Verified 1.05335349781695 0.146089504220757 no 766 0.126970421467282 499 NA FT PLASMA MEMBRANE Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; TPO3 has a paralog, TPO2, that arose from the whole genome duplication spermine transport spermine transmembrane transporter activity fungal-type vacuole membrane|integral to membrane|plasma membrane
YBR016W YBR016W YBR016W hom Verified 1.05279464606769 0.146217559648398 no 767 0.150265363252511 577 NA FT PLASMA MEMBRANE Tail-anchored plasma membrane protein with a conserved CYSTM module; predicted to be palmitoylated; has similarity to hydrophilins, which are involved in the adaptive response to hyperosmotic conditions; YBR016W has a paralog, YDL012C, that arose from the whole genome duplication biological_process molecular_function cellular bud membrane|plasma membrane|mating projection membrane
YOR308C YOR308C SNU66 hom Verified 1.05269273781741 0.146240919054357 no 768 0.147649898163777 524 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Component of the U4/U6.U5 snRNP complex involved in pre-mRNA splicing via spliceosome; also required for pre-5S rRNA processing and may act in concert with Rnh70p; has homology to human SART-1 maturation of 5S rRNA|mRNA splicing, via spliceosome molecular_function U4/U6 x U5 tri-snRNP complex
YDR200C YDR200C VPS64 hom Verified 1.05208049878652 0.146381309220988 no 769 0.187602066891823 636 NA FT PROTEIN LOCALIZATION|CELL CYCLE|SIGNALING|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein required for cytoplasm to vacuole targeting of proteins; forms a complex with Far3p and Far7p to Far11p involved in recovery from pheromone-induced cell cycle arrest; mutant has increased aneuploidy tolerance re-entry into mitotic cell cycle after pheromone arrest|protein targeting to vacuole molecular_function endoplasmic reticulum membrane|cytoplasm
YDR384C YDR384C ATO3 hom Verified 1.05094274013131 0.146642444515747 no 770 0.140631932430153 478 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION|PLASMA MEMBRANE Plasma membrane protein, regulation pattern suggests a possible role in export of ammonia from the cell; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family of putative transporters ammonium transport|nitrogen utilization|transmembrane transport ammonium transmembrane transporter activity mitochondrion|integral to membrane|plasma membrane
YOR223W YOR223W YOR223W hom Verified 1.05076086197573 0.146684217662089 no 771 0.147145992206731 528 NA FT ENDOPLASMIC RETICULUM Subunit of the DSC ubiquitin ligase complex; protein of unknown function that localizes to the ER and vacuole lumen; overexpression affects endocytic protein trafficking; ortholog of fission yeast dsc3 biological_process molecular_function fungal-type vacuole lumen|endoplasmic reticulum
YFR053C YFR053C HXK1 hom Verified 1.05062133337194 0.146716269521604 no 772 0.165338132551005 580 NA FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Hexokinase isoenzyme 1; a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves hexokinase Hxk2p; HXK1 has a paralog, HXK2, that arose from the whole genome duplication mannose metabolic process|glucose import|glycolysis|fructose import|glucose metabolic process|fructose metabolic process hexokinase activity cytosol|mitochondrion|cytoplasm
YKR104W YKR104W YKR104W hom Verified 1.04520077054791 0.147965093701628 no 773 0.145142035925635 534 NA FT NUCLEOTIDE METABOLISM Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; contains a stop codon in S288C; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds transport ATPase activity, coupled to transmembrane movement of substances integral to membrane|membrane
YMR223W YMR223W UBP8 hom Verified 1.0438791908398 0.148270643458735 no 774 0.129421241121195 496 NA FT CHROMATIN ORGANIZATION|PROTEOLYSIS NUCLEUS HISTONE ACETYLTRANSFERASE Ubiquitin-specific protease that is a component of the SAGA (Spt-Ada-Gcn5-Acetyltransferase) acetylation complex; required for SAGA-mediated deubiquitination of histone H2B histone H3-K4 methylation|histone deubiquitination|histone H3-K79 methylation ubiquitin-specific protease activity|protein complex scaffold DUBm complex|SLIK (SAGA-like) complex|SAGA complex
YER091C-A_d YER091C-A YER091C-A hom Dubious 1.03931848966056 0.149328319246275 no 775 0.165224160222652 566 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YFR040W YFR040W SAP155 hom Verified 1.03860149817006 0.149495054376432 no 776 0.160279167424075 605 NA FT CELL CYCLE Protein required for function of the Sit4p protein phosphatase; forms a complex with Sit4p; member of a family of similar proteins including Sap4p, Sap185p, and Sap190p; protein abundance increases in response to DNA replication stress G1/S transition of mitotic cell cycle protein serine/threonine phosphatase activity cytoplasm
YBR086C YBR086C IST2 hom Verified 1.0384313470458 0.149534640961314 no 777 0.162755691644894 549 NA FT PLASMA MEMBRANE Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localizes to the mother cell in small-budded cells and to the bud in medium- and large-budded cells; mRNA is transported to the bud tip by an actomyosin-driven process response to osmotic stress lipid binding integral to membrane|cellular bud membrane|plasma membrane
YOR162C YOR162C YRR1 hom Verified 1.03678830533619 0.149917263476714 no 778 0.207204517322675 737 NA FF|FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO OXIDATIVE STRESS NUCLEUS Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication regulation of transcription from RNA polymerase II promoter in response to oxidative stress|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity nucleus
YER119C-A_d YER119C-A YER119C-A hom Dubious 1.03673822855981 0.149928935324687 no 779 0.190158673559521 701 NA FF Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene SCS2 Unknown Unknown Unknown
YER007W YER007W PAC2 hom Verified 1.03619828944062 0.150054822318837 no 780 0.150332753106659 548 NA FT CYTOSKELETON Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl protein folding|tubulin complex assembly|tubulin complex biogenesis alpha-tubulin binding cellular_component
YGL083W YGL083W SCY1 hom Verified 1.03574283988397 0.150161065319527 no 781 0.130637913916096 473 NA FT PROTEIN PHOSPHORYLATION Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase biological_process molecular_function clathrin-coated vesicle
YKL016C YKL016C ATP7 hom Verified 1.03504194177169 0.150324662190352 no 782 0.15732277227481 561 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS MITOCHONDRION Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis protein complex assembly|ATP synthesis coupled proton transport hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism mitochondrion|mitochondrial proton-transporting ATP synthase, stator stalk|integral to membrane|mitochondrial proton-transporting ATP synthase complex
YEL017C-A YEL017C-A PMP2 hom Verified 1.03380481658514 0.150613709731427 no 783 0.166683265841966 565 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog, PMP1, that arose from the whole genome duplication cation transport molecular_function membrane
YDR297W YDR297W SUR2 hom Verified 1.03357699904833 0.150666978385364 no 784 0.165873873667646 554 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis sphingolipid metabolic process sphingosine hydroxylase activity integral to membrane|endoplasmic reticulum membrane
YKL217W YKL217W JEN1 hom Verified 1.03214129191693 0.151002966318705 no 785 0.145603785976508 520 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION|PLASMA MEMBRANE Monocarboxylate/proton symporter of the plasma membrane; transport activity is dependent on the pH gradient across the membrane; mediates high-affinity uptake of carbon sources lactate, pyuvate, and acetate, and also of the micronutrient selenite, whose structure mimics that of monocarboxylates; expression and localization are tightly regulated, with transcription repression, mRNA degradation, and protein endocytosis and degradation all occurring in the presence of glucose plasma membrane lactate transport|plasma membrane selenite transport|plasma membrane pyruvate transport selenite:hydrogen symporter activity|secondary active monocarboxylate transmembrane transporter activity mitochondrion|integral to membrane|plasma membrane
YOR263C_d YOR263C YOR263C hom Dubious 1.0284635901373 0.151865904676866 no 786 0.154260935155832 545 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF DES3/YOR264W Unknown Unknown Unknown
YOR083W YOR083W WHI5 hom Verified 1.02829932045528 0.151904525312591 no 787 0.12785783287332 434 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE NUCLEUS Repressor of G1 transcription that binds to SCB binding factor (SBF) at SCB target promoters in early G1; phosphorylation of Whi5p by the CDK, Cln3p/Cdc28p relieves repression and promoter binding by Whi5; periodically expressed in G1 negative regulation of transcription involved in G1/S phase of mitotic cell cycle|regulation of cell size RNA polymerase II transcription factor recruiting transcription factor activity|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription SBF transcription complex|nucleus|cytoplasm
YOL036W_p YOL036W YOL036W hom Uncharacterized 1.02714297059981 0.152176573644139 no 788 0.150487068548257 525 NA Protein of unknown function; potential Cdc28p substrate; YOL036W has a paralog, YIR016W, that arose from the whole genome duplication biological_process molecular_function cellular_component
YIL170W YIL170W HXT12 hom pseudogene 1.02507781036369 0.152663237333391 no 789 0.142010753327029 515 NA Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family hexose transport|biological_process hexose transmembrane transporter activity|molecular_function integral to membrane
YNL065W YNL065W AQR1 hom Verified 1.02498995164265 0.152683964481002 no 790 0.134735020582367 493 NA FT PLASMA MEMBRANE Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids; AQR1 has a paralog, QDR1, that arose from the whole genome duplication; relocalizes from plasma membrane to cytoplasm upon DNA replication stress monocarboxylic acid transport|drug transmembrane transport|amino acid export monocarboxylic acid transmembrane transporter activity|drug transmembrane transporter activity integral to membrane|plasma membrane
YBR273C YBR273C UBX7 hom Verified 1.02344882752185 0.153047841579941 no 791 0.128863880068687 490 NA FT PROTEOLYSIS ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p; UBX7 has a paralog, UBX6, that arose from the whole genome duplication sporulation resulting in formation of a cellular spore|ubiquitin-dependent protein catabolic process molecular_function nuclear envelope|endoplasmic reticulum
YHR195W YHR195W NVJ1 hom Verified 1.02225013992854 0.153331262601679 no 792 0.166764865536196 602 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|NUCLEUS Nuclear envelope protein, anchored to the nuclear inner membrane, that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN) microautophagy|cellular protein localization protein binding nuclear envelope
YPR174C YPR174C YPR174C hom Verified 1.02165199854068 0.153472818776578 no 793 0.14393457342215 496 NA FT ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery; potential Cdc28p substrate; binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study; relative distribution to foci at the nuclear periphery increases upon DNA replication stress; YPR174C has a paralog, NBP1, that arose from the whole genome duplication biological_process molecular_function nuclear envelope|spindle pole body
YDR058C YDR058C TGL2 hom Verified 1.01921201785994 0.15405116120842 no 794 0.15886919575116 572 NA FT PROTEIN LOCALIZATION|LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION Triacylglycerol lipase that is localized to the mitochondria; has lipolytic activity towards triacylglycerols and diacylglycerols when expressed in E. coli triglyceride catabolic process triglyceride lipase activity mitochondrion
YKL212W YKL212W SAC1 hom Verified 1.01839906284647 0.154244173693694 no 795 0.262501327163506 934 NA FF|FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS Phosphatidylinositol phosphate (PtdInsP) phosphatase; involved in hydrolysis of PtdIns[4]P in the early and medial Golgi; regulated by interaction with Vps74p; ER localized transmembrane protein which cycles through the Golgi; involved in protein trafficking and processing, secretion, and cell wall maintenance; regulates sphingolipid biosynthesis through the modulation of PtdIns(4)P metabolism phosphatidylinositol dephosphorylation phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity|phosphatidylinositol-3-phosphatase activity|phosphatidylinositol-4-phosphate phosphatase activity mitochondrial outer membrane|integral to endoplasmic reticulum membrane|mitochondrion|SPOTS complex|integral to Golgi membrane
YLR460C_p YLR460C YLR460C hom Uncharacterized 1.01797949337113 0.154343850786653 no 796 0.141811898259553 516 NA FT OXIDATION-REDUCTION PROCESS Member of the quinone oxidoreductase family, up-regulated in response to the fungicide mancozeb; possibly up-regulated by iodine biological_process molecular_function cellular_component
YDL068W_d YDL068W YDL068W hom Dubious 1.01673142858745 0.154640605186349 no 797 0.18071078142772 654 NA Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YKR033C_d YKR033C YKR033C hom Dubious 1.01570551402854 0.15488482073315 no 798 0.155108559512434 501 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene DAL80 Unknown Unknown Unknown
YKR091W YKR091W SRL3 hom Verified 1.01515490036403 0.155015997479713 no 799 0.159601659251251 604 NA Cytoplasmic protein that, when overexpressed, suppresses the lethality of a rad53 null mutation; potential Cdc28p substrate nucleobase-containing compound metabolic process molecular_function cytoplasm
YMR002W YMR002W MIC17 hom Verified 1.01416063671787 0.155253054020985 no 800 0.16388396487437 573 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS|MITOCHONDRION Mitochondrial intermembrane space protein; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress aerobic respiration molecular_function nucleus|cytoplasm|mitochondrial intermembrane space
YFR048W YFR048W RMD8 hom Verified 1.01147235936821 0.155895201966717 no 801 0.156332638035725 555 NA FT CELL CYCLE Cytosolic protein required for sporulation biological_process molecular_function cytoplasm
YAL026C YAL026C DRS2 hom Verified 1.00960315389348 0.156342728993452 no 802 0.176302886512613 621 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RIBOSOME BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS GOLGI APPARATUS Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation and endocytosis; mutations in human homolog ATP8B1 result in liver disease intracellular protein transport|post-Golgi vesicle-mediated transport|phospholipid translocation|endocytosis|ribosomal small subunit assembly phospholipid-translocating ATPase activity trans-Golgi network|integral to membrane
YAR023C_p YAR023C YAR023C hom Uncharacterized 1.00846945173252 0.156614572931024 no 803 0.155643508272957 549 NA Putative integral membrane protein, member of DUP240 gene family biological_process molecular_function cellular_component
YOL009C YOL009C MDM12 hom Verified 1.00308612388718 0.157909654580719 no 804 0.155451819436924 584 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION Mitochondrial outer membrane protein, required for transmission of mitochondria to daughter cells; component of the ERMES complex that links the ER to mitochondria; may influence import and assembly of outer membrane beta-barrel proteins mitochondrion inheritance|mitochondrion organization|protein import into mitochondrial outer membrane|phospholipid transport molecular_function mitochondrial outer membrane|mitochondrion|ERMES complex
YJL149W YJL149W DAS1 hom Verified 1.00228252721929 0.158103579491253 no 805 0.172017578921678 626 NA FT PROTEOLYSIS UBIQUITIN LIGASE COMPLEX Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity|protein binding, bridging SCF ubiquitin ligase complex
YCL051W YCL051W LRE1 hom Verified 1.00148569366577 0.158296026607895 no 806 0.173372923256275 615 NA FT CELL WALL ORG/BIOGENESIS Protein involved in control of cell wall structure and stress response; overproduction confers resistance to cell-wall degrading enzymes; exhibits genetic interactions with genes involved in the cell wall integrity pathway;
LRE1 has a paralog, HLR1, that arose from the whole genome duplication fungal-type cell wall organization molecular_function cellular_component
YML011C YML011C RAD33 hom Verified 1.00140710173116 0.158315016049204 no 807 0.141971345217324 505 NA FT RESPONSE TO DNA DAMAGE NUCLEUS Protein involved in nucleotide excision repair; green fluorescent protein (GFP)-fusion protein localizes to the nucleus nucleotide-excision repair molecular_function nucleus
YBR054W YBR054W YRO2 hom Verified 0.999187235623563 0.158851999037706 no 808 0.137970271683972 515 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Protein of unknown function with similarity to archaeal rhodopsins; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; transcriptionally regulated by Haa1p; YRO2 has a paralog, MRH1, that arose from the whole genome duplication biological_process molecular_function mitochondrion|integral to membrane|cellular bud
YCR045C YCR045C RRT12 hom Verified 0.996898504224161 0.15940688890116 no 809 0.165767639453521 602 NA FT CELL WALL ORG/BIOGENESIS|PROTEOLYSIS ENDOMEMBRANE SYSTEM|NUCLEUS Probable subtilisin-family protease with a role in formation of the dityrosine layer of spore walls; localizes to the spore wall and also the nuclear envelope and ER region in mature spores ascospore wall assembly serine-type peptidase activity nuclear envelope|ascospore wall
YHR163W YHR163W SOL3 hom Verified 0.995742840047448 0.15968755467037 no 810 0.154562270948177 574 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS NUCLEUS 6-phosphogluconolactonase; catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p; SOL3 has a paralog, SOL4, that arose from the whole genome duplication pentose-phosphate shunt, oxidative branch 6-phosphogluconolactonase activity nucleus|cytoplasm
YDL192W YDL192W ARF1 hom Verified 0.995205748721934 0.159818103205912 no 811 0.19048485808861 662 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|RESPONSE TO NUTRIENT LEVELS GOLGI APPARATUS ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication ER to Golgi vesicle-mediated transport|Golgi to plasma membrane transport|intra-Golgi vesicle-mediated transport|macroautophagy GTPase activity cytosol|Golgi-associated vesicle
YMR120C YMR120C ADE17 hom Verified 0.992986151613382 0.16035835162065 no 812 0.137857134145344 524 NA FT NUCLEOTIDE METABOLISM Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE17 has a paralog, ADE16, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine purine nucleotide biosynthetic process|'de novo' IMP biosynthetic process phosphoribosylaminoimidazolecarboxamide formyltransferase activity|IMP cyclohydrolase activity cytosol|plasma membrane
YJL089W YJL089W SIP4 hom Verified 0.992423450996516 0.160495501971844 no 813 0.169657322907631 617 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS NUCLEUS C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source|positive regulation of gluconeogenesis|positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter|Unknown RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YNL095C_p YNL095C YNL095C hom Uncharacterized 0.99206360425625 0.160583249709207 no 814 0.155363736830879 565 NA Putative protein of unknown function; predicted to contain a transmembrane domain; not an essential gene; YNL095C has a paralog, ECM3, that arose from the whole genome duplication biological_process molecular_function integral to membrane
YGR281W YGR281W YOR1 hom Verified 0.991900934468428 0.160622926617359 no 815 0.176529734599151 626 NA FT NUCLEOTIDE METABOLISM PLASMA MEMBRANE Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter mediates export of many different organic anions including oligomycin; similar to human cystic fibrosis transmembrane receptor (CFTR) transport|response to drug xenobiotic-transporting ATPase activity integral to membrane|plasma membrane
YBR071W YBR071W YBR071W hom Verified 0.990968408667866 0.160850503227934 no 816 0.148128226073606 487 NA FT SITE OF POLARIZED GROWTH Protein of unknown function found in the cytoplasm and bud neck; mRNA expression may be regulated by the cell cycle and/or cell wall stress; overexpression of YBR071W affects endocytic protein trafficking biological_process molecular_function cellular bud neck|cytoplasm
YOL006C YOL006C TOP1 hom Verified 0.989417894323386 0.161229361512657 no 817 0.165681190095459 582 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|CHROMOSOME SEGREGATION|GENE SILENCING NUCLEUS|CHROMOSOME Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination nuclear migration|chromatin assembly or disassembly|DNA topological change|DNA strand elongation involved in DNA replication|regulation of mitotic recombination|chromatin silencing at rDNA|regulation of transcription from RNA polymerase II promoter|mitotic chromosome condensation|transcription elongation from RNA polymerase II promoter DNA topoisomerase type I activity replication fork protection complex|nucleolus|nucleus
YLR055C YLR055C SPT8 hom Verified 0.988861925310515 0.161365350668536 no 818 0.169199759144093 607 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS HISTONE ACETYLTRANSFERASE Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters histone acetylation|negative regulation of transcription from RNA polymerase II promoter|chromatin modification|positive regulation of transcription from RNA polymerase II promoter TBP-class protein binding|transcription cofactor activity nucleus|SAGA complex
YER178W YER178W PDA1 hom Verified 0.988004534574206 0.161575213700834 no 819 0.181388670296536 628 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose acetyl-CoA biosynthetic process from pyruvate pyruvate dehydrogenase (acetyl-transferring) activity mitochondrial nucleoid|mitochondrion|mitochondrial pyruvate dehydrogenase complex
YER045C YER045C ACA1 hom Verified 0.986620836580349 0.161914275773242 no 820 0.149975846066843 516 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS ATF/CREB family basic leucine zipper (bZIP) transcription factor; binds as a homodimer to the ATF/CREB consensus sequence TGACGTCA; important for carbon source utilization; target genes include GRE2 and COS8; ACA1 has a paralog, CST6, that arose from the whole genome duplication positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YGR151C_d YGR151C YGR151C hom Dubious 0.98586382034097 0.162099971453549 no 821 0.160993223039379 573 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF RSR1/BUD1/YGR152C; relative distribution to the nucleus increases upon DNA replication stress Unknown Unknown Unknown
YHR104W YHR104W GRE3 hom Verified 0.985789406454672 0.162118232624125 no 822 0.159331590831656 576 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS NUCLEUS Aldose reductase; involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress galactose catabolic process|cellular response to oxidative stress|arabinose catabolic process|D-xylose catabolic process|response to stress D-xylose:NADP reductase activity|mRNA binding|glucose 1-dehydrogenase (NADP+) activity|alditol:NADP+ 1-oxidoreductase activity nucleus|cytoplasm
YOR243C YOR243C PUS7 hom Verified 0.985348201133842 0.162226531944681 no 823 0.184522718499955 612 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Pseudouridine synthase, catalyzes pseudouridylation at positions 35 and 56 in U2 snRNA, position 50 in 5S rRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); conserved in archaea, vertebrates, and some bacteria snRNA pseudouridine synthesis|tRNA pseudouridine synthesis|enzyme-directed rRNA pseudouridine synthesis pseudouridine synthase activity nucleus
YOR144C YOR144C ELG1 hom Verified 0.985312877799463 0.162235204531468 no 824 0.154904541229203 571 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS|MITOCHONDRION|CHROMOSOME Subunit of an alternative replication factor C complex important for DNA replication and genome integrity; suppresses spontaneous DNA damage; involved in homologous recombination-mediated repair and telomere homeostasis; required for PCNA (Pol30p) unloading during DNA replication negative regulation of DNA recombination|negative regulation of transposition, RNA-mediated|telomere maintenance|double-strand break repair via homologous recombination|DNA-dependent DNA replication|mitotic sister chromatid cohesion chromatin binding Elg1 RFC-like complex|mitochondrion|nucleus|cytoplasm
YCR091W YCR091W KIN82 hom Verified 0.984581161303976 0.162414923489806 no 825 0.142559105874203 530 NA FT MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION Putative serine/threonine protein kinase implicated in the regulation of phospholipid asymmetry through the activation of phospholipid translocases (flippases) Lem3p-Dnf1p/Dnf2p; similar to Fpk1p phospholipid translocation|protein phosphorylation|response to pheromone protein kinase activity cellular_component
YDL167C YDL167C NRP1 hom Verified 0.984003376517223 0.162556926362711 no 826 0.173571415811965 555 NA Putative RNA binding protein of unknown function; localizes to stress granules induced by glucose deprivation; predicted to be involved in ribosome biogenesis biological_process molecular_function cytoplasmic stress granule|cytoplasm
YGL101W_p YGL101W YGL101W hom Uncharacterized 0.983193977911306 0.162755989052081 no 827 0.165188653533569 492 NA FT NUCLEUS Putative protein of unknown function; non-essential gene with similarity to YBR242W; interacts with the DNA helicase Hpr5p biological_process molecular_function nucleus|cytoplasm
YJR070C YJR070C LIA1 hom Verified 0.982484342940662 0.162930646352458 no 828 0.172066608681351 583 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CYTOSKELETON ORGANIZATION NUCLEUS Deoxyhypusine hydroxylase; HEAT-repeat containing metalloenzyme that catalyzes hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning; protein abundance increases in response to DNA replication stress microtubule cytoskeleton organization|peptidyl-lysine modification to hypusine deoxyhypusine monooxygenase activity nucleus|cytoplasm
YJL067W_d YJL067W YJL067W hom Dubious 0.982028286971427 0.163042956393891 no 829 0.142964771651708 493 NA Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR530C YDR530C APA2 hom Verified 0.981843409679721 0.163088499295698 no 830 0.109981068982187 388 NA FT NUCLEOTIDE METABOLISM NUCLEUS Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication nucleoside catabolic process bis(5'-nucleosyl)-tetraphosphatase activity nucleus|cytoplasm
YDR265W YDR265W PEX10 hom Verified 0.981747401443889 0.163112153345406 no 831 0.161004932721726 572 NA FT PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION Peroxisomal membrane E3 ubiquitin ligase, required for for Ubc4p-dependent Pex5p ubiquitination and peroxisomal matrix protein import; contains zinc-binding RING domain; mutations in human homolog cause various peroxisomal disorders protein import into peroxisome matrix|protein ubiquitination ubiquitin-protein ligase activity|protein binding peroxisomal membrane
YPL267W YPL267W ACM1 hom Verified 0.979196525404547 0.163741442555672 no 832 0.174498733464412 628 NA FT CELL CYCLE|CELL DIVISION NUCLEUS Pseudosubstrate inhibitor of the anaphase-promoting complex/cyclosome (APC/C), that suppresses APC/C [Cdh1]-mediated proteolysis of mitotic cyclins; associates with Cdh1p, Bmh1p and Bmh2p; cell cycle regulated protein negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle ubiquitin-protein ligase inhibitor activity nucleus|cytoplasm
YNL194C YNL194C YNL194C hom Verified 0.979187325580769 0.163743714957583 no 833 0.153417320276695 530 NA FT ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Integral membrane protein required for sporulation and plasma membrane sphingolipid content; has sequence similarity to SUR7 and FMP45; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; GFP-fusion protein is more abundant at MCCs (membrane compartment occupied by Can1) in the presence of glycerol and oleate ascospore formation molecular_function cell cortex|integral to membrane|endoplasmic reticulum|plasma membrane|cytoplasm
YBR005W YBR005W RCR1 hom Verified 0.978470863013835 0.163920747623641 no 834 0.151128901018698 531 NA FT VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein of the ER membrane involved in cell wall chitin deposition; may function in the endosomal-vacuolar trafficking pathway, helping determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR1 has a paralog, RCR2, that arose from the whole genome duplication fungal-type cell wall organization|vesicle-mediated transport molecular_function integral to endoplasmic reticulum membrane
YPR084W_p YPR084W YPR084W hom Uncharacterized 0.978290196155088 0.16396540868504 no 835 0.163288600840303 557 NA Putative protein of unknown function biological_process molecular_function cellular_component
YOR113W YOR113W AZF1 hom Verified 0.978147561932584 0.164000673610177 no 836 0.184412814761578 606 NA FT TRANSCRIPTION FROM RNA POL II|CELL WALL ORG/BIOGENESIS NUCLEUS Zinc-finger transcription factor; in the presence of glucose, activates transcription of genes involved in growth and carbon metabolism; in nonfermentable carbon sources, activates transcription of genes involved in maintenance of cell wall integrity regulation of fungal-type cell wall organization|regulation of transcription from RNA polymerase II promoter|cellular response to carbohydrate stimulus RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YLL063C YLL063C AYT1 hom Verified 0.977218388298864 0.164230523189159 no 837 0.133734309603649 451 NA Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis secondary metabolic process trichothecene 3-O-acetyltransferase activity cellular_component
YGL236C YGL236C MTO1 hom Verified 0.976233044815618 0.164474495611712 no 838 0.182436260237873 604 NA FT RNA PROCESSING|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants mitochondrial tRNA wobble uridine modification molecular_function mitochondrion
YPR200C YPR200C ARR2 hom Verified 0.975515533859075 0.16465230006501 no 839 0.148915079980291 511 NA Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p response to arsenic-containing substance arsenate reductase activity cellular_component
YLR365W_d YLR365W YLR365W hom Dubious 0.97438119473733 0.164933651570371 no 840 0.131020368870107 463 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious gene YLR364C-A; YLR365W is not an essential gene Unknown Unknown Unknown
YBR278W YBR278W DPB3 hom Verified 0.973039818548947 0.165266756238642 no 841 0.172574761786837 590 NA FT RESPONSE TO DNA DAMAGE|GENE SILENCING NUCLEUS|CHROMOSOME Third-largest subunit of DNA polymerase II (DNA polymerase epsilon); required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; mRNA abundance peaks at the G1/S boundary of the cell cycle; DPB3 has a paralog, DLS1, that arose from the whole genome duplication DNA-dependent DNA replication|chromatin silencing at telomere double-stranded DNA binding|single-stranded DNA binding|DNA-directed DNA polymerase activity epsilon DNA polymerase complex
YOR090C YOR090C PTC5 hom Verified 0.972336247726235 0.165441648302242 no 842 0.170080974414267 522 NA FT MITOCHONDRION Mitochondrial type 2C protein phosphatase (PP2C) involved in regulation of pyruvate dehydrogenase activity by dephosphorylating the serine 133 of the Pda1p subunit; localizes to the intermembrane space and is imported via the presequence pathway and processed by the inner membrane protease (Imp1p-Imp2p); acts in concert with kinases Pkp1p and Pkp2p and phosphatase Ptc6p positive regulation of catalytic activity|regulation of catalytic activity|protein dephosphorylation [pyruvate dehydrogenase (lipoamide)] phosphatase activity|protein serine/threonine phosphatase activity mitochondrion
YIL073C YIL073C SPO22 hom Verified 0.969661335948117 0.16610766437367 no 843 0.13980711399781 544 NA FT CELL CYCLE NUCLEUS|CHROMOSOME Meiosis-specific protein essential for chromosome synapsis, involved in completion of nuclear divisions during meiosis; induced early in meiosis regulation of synaptonemal complex assembly molecular_function condensed nuclear chromosome
YBR279W YBR279W PAF1 hom Verified 0.969345740388309 0.166186357391376 no 844 0.239904308541545 837 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|GENE SILENCING NUCLEUS|CHROMOSOME RNA POL II, HOLOENZYME Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cell cycle-regulated genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; homolog of human PD2/hPAF1 negative regulation of DNA recombination|mRNA 3'-end processing|snoRNA transcription from an RNA polymerase II promoter|regulation of transcription by chromatin organization|transcription from RNA polymerase I promoter|regulation of transcription-coupled nucleotide-excision repair|rRNA processing|transcription elongation from RNA polymerase I promoter|regulation of chromatin silencing at telomere|regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of histone H3-K4 methylation|negative regulation of transcription from RNA polymerase II promoter|global genome nucleotide-excision repair|chromatin silencing at rDNA|Unknown|snoRNA 3'-end processing|transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|chromatin binding|TFIIF-class binding transcription factor activity|RNA polymerase II core binding|RNA polymerase II transcription factor binding transcription factor activity transcriptionally active chromatin|nucleus|Cdc73/Paf1 complex
YOR382W YOR382W FIT2 hom Verified 0.96869450268041 0.166348818101066 no 845 0.128192861308159 429 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall siderophore transport molecular_function fungal-type cell wall
YPR114W_p YPR114W YPR114W hom Uncharacterized 0.968564860460688 0.166381171472633 no 846 0.176485492013595 615 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Putative protein of unknown function biological_process molecular_function integral to membrane|endoplasmic reticulum
YJR105W YJR105W ADO1 hom Verified 0.968372060343877 0.16642929397418 no 847 0.23602603813629 810 NA FF|FT NUCLEOTIDE METABOLISM NUCLEUS Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle purine nucleobase metabolic process adenosine kinase activity nucleus|cytoplasm
YAR014C YAR014C BUD14 hom Verified 0.967597016210481 0.166622834012238 no 848 0.1604697531519 657 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH Protein involved in bud-site selection; Bud14p-Glc7p complex is a cortical regulator of dynein; inhibitor of the actin assembly factor Bnr1p (formin); diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; relative distribution to the nucleus increases upon DNA replication stress regulation of cell shape during vegetative growth phase|regulation of protein localization|regulation of transcription, DNA-dependent|cytoskeleton organization|negative regulation of actin filament polymerization protein phosphatase type 1 regulator activity incipient cellular bud site|cellular bud neck|cellular bud tip
YDR401W_d YDR401W YDR401W hom Dubious 0.965693892661733 0.167098688223254 no 849 0.179509763993152 605 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOR295W YOR295W UAF30 hom Verified 0.96426671378178 0.167456112287414 no 850 0.158988487331429 587 NA FT CHROMATIN ORGANIZATION NUCLEUS Subunit of UAF (upstream activation factor); UAF is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; deletion decreases cellular growth rate; UAF30 has a paralog, TRI1, that arose from the whole genome duplication transcription of nuclear large rRNA transcript from RNA polymerase I promoter|chromatin organization RNA polymerase I upstream control element sequence-specific DNA binding|RNA polymerase I upstream control element sequence-specific DNA binding transcription factor activity nucleolus|RNA polymerase I upstream activating factor complex
YER110C YER110C KAP123 hom Verified 0.963911467270364 0.167545157079593 no 851 0.157639155844462 570 NA FT PROTEIN LOCALIZATION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE Karyopherin beta, mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1 NLS-bearing substrate import into nucleus|Unknown|protein import into nucleus|ribosomal protein import into nucleus protein transporter activity|nuclear localization sequence binding integral to membrane|nucleus|nuclear pore|cytoplasm
YNL242W YNL242W ATG2 hom Verified 0.963436127773016 0.167664351643896 no 852 0.158102311447448 542 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION Peripheral membrane protein required for autophagic vesicle formation; also required for vesicle formation during pexophagy and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria; forms cytoplasmic foci upon DNA replication stress mitochondrion degradation|piecemeal microautophagy of nucleus|peroxisome degradation|CVT pathway|autophagic vacuole assembly molecular_function pre-autophagosomal structure|cytoplasm|extrinsic to membrane
YBR175W YBR175W SWD3 hom Verified 0.962184928573603 0.167978359226924 no 853 0.164756388401189 578 NA FT CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5 histone H3-K4 methylation|telomere maintenance|chromatin silencing at telomere histone methyltransferase activity (H3-K4 specific) Set1C/COMPASS complex
YPL001W YPL001W HAT1 hom Verified 0.961243134221915 0.168214966446603 no 854 0.185498701854395 630 NA FT CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING NUCLEUS HISTONE ACETYLTRANSFERASE Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A, to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair histone acetylation|chromatin silencing at telomere histone acetyltransferase activity|histone binding histone acetyltransferase complex|nucleus|cytoplasm
YNL297C YNL297C MON2 hom Verified 0.961233391540726 0.168217415222642 no 855 0.202176725416881 634 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Peripheral membrane protein with a role in endocytosis and vacuole integrity, interacts with Arl1p and localizes to the endosome; member of the Sec7p family of proteins transport|endocytosis|protein targeting to vacuole|Golgi to endosome transport guanyl-nucleotide exchange factor activity cytosol|endosome|trans-Golgi network|extrinsic to membrane
YER005W YER005W YND1 hom Verified 0.960910069855906 0.168298693581023 no 856 0.166918219969021 583 NA FT LIPID METABOLISM|CARBOHYDRATE METABOLISM GOLGI APPARATUS Apyrase with wide substrate specificity, helps prevent inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates that inhibit glycotransferases; partially redundant with Gda1p; mediates adenovirus E4orf4-induced toxicity protein glycosylation nucleoside-triphosphatase activity|nucleoside-diphosphatase activity COPI-coated vesicle|Golgi apparatus|membrane|Golgi membrane
YGL059W YGL059W PKP2 hom Verified 0.958705973906035 0.168853444065516 no 857 0.168652751002584 569 NA FT CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION MITOCHONDRION Mitochondrial protein kinase; negatively regulates activity of the pyruvate dehydrogenase complex by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp1p and phosphatases Ptc5p and Ptc6p; relocalizes from mitochondrion to cytoplasm upon DNA replication stress peptidyl-serine phosphorylation|protein phosphorylation|carbon utilization|negative regulation of catalytic activity protein kinase activity|pyruvate dehydrogenase (acetyl-transferring) kinase activity mitochondrion
YPL229W_p YPL229W YPL229W hom Uncharacterized 0.957932499846492 0.16904839847191 no 858 0.169656719122455 622 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; not an essential gene; YPL229W has a paralog, YMR181C, that arose from the whole genome duplication biological_process molecular_function cytoplasm
YPR170C_d YPR170C YPR170C hom Dubious 0.957111891250224 0.169255391133736 no 859 0.224794765872987 713 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORFs YPR169W-A and YPR170W-B Unknown Unknown Unknown
YKL128C YKL128C PMU1 hom Verified 0.955470931088135 0.169669799400646 no 860 0.131377271409667 463 NA FT NUCLEUS Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant biological_process molecular_function nucleus|cytoplasm
YML041C YML041C VPS71 hom Verified 0.954740117496003 0.16985456843957 no 861 0.210232913047202 742 NA FF|FT PROTEIN LOCALIZATION|CHROMATIN ORGANIZATION|VACUOLAR TRANSPORT NUCLEUS|CHROMOSOME Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting chromatin remodeling|protein targeting to vacuole|histone exchange nucleosome binding Swr1 complex|nucleus
YNL322C YNL322C KRE1 hom Verified 0.954689498929744 0.169867370929981 no 862 0.183751065163654 673 NA FT CELL WALL ORG/BIOGENESIS PLASMA MEMBRANE Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor fungal-type cell wall organization structural constituent of cell wall fungal-type cell wall|integral to membrane
YGR239C YGR239C PEX21 hom Verified 0.952718472996619 0.170366365528032 no 863 0.185191867833914 607 NA FT PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION Peroxin required for peroxisomal matrix protein targeting; acts on proteins containing the PTS2 targeting sequence; interacts with Pex7p; partially redundant with Pex18p; relative distribution to cytoplasmic foci increases upon DNA replication stress protein import into peroxisome matrix|positive regulation of protein binding protein binding cytosol|peroxisome
YLR267W_p YLR267W BOP2 hom Uncharacterized 0.952527350215258 0.170414800994162 no 864 0.114292522389429 404 NA Protein of unknown function biological_process molecular_function cellular_component
YAL013W YAL013W DEP1 hom Verified 0.951979651039913 0.170553651004335 no 865 0.174886999834387 605 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Transcriptional modulator involved in regulation of structural phospholipid biosynthesis genes and metabolically unrelated genes, as well as maintenance of telomeres, mating efficiency, and sporulation positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of chromatin silencing at rDNA|regulation of transcription from RNA polymerase II promoter|histone deacetylation|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of chromatin silencing at telomere|negative regulation of transcription from RNA polymerase II promoter|regulation of DNA-dependent DNA replication initiation|Unknown molecular_function Rpd3L-Expanded complex|Rpd3L complex
YJL060W YJL060W BNA3 hom Verified 0.951807659442958 0.170597268411691 no 866 0.168952701815862 592 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Kynurenine aminotransferase, catalyzes formation of kynurenic acid from kynurenine; potential Cdc28p substrate kynurenic acid biosynthetic process arylformamidase activity|kynurenine-oxoglutarate transaminase activity mitochondrion|cytoplasm
YOR035C YOR035C SHE4 hom Verified 0.951744210019083 0.170613361113508 no 867 0.273340196962706 965 NA FF|FT CYTOSKELETON ORGANIZATION|RNA LOCALIZATION Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization mating type switching|intracellular mRNA localization|actin cytoskeleton organization myosin binding cytoplasm
YDL168W YDL168W SFA1 hom Verified 0.950517342647881 0.170924723022746 no 868 0.208525735637344 686 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION Bifunctional alcohol dehydrogenase and formaldehyde dehydrogenase; formaldehyde dehydrogenase activity is glutathione-dependent; functions in formaldehyde detoxification and formation of long chain and complex alcohols, regulated by Hog1p-Sko1p; protein abundance increases in response to DNA replication stress furaldehyde metabolic process|formaldehyde catabolic process|amino acid catabolic process to alcohol via Ehrlich pathway S-(hydroxymethyl)glutathione dehydrogenase activity|hydroxymethylfurfural reductase (NADH) activity|alcohol dehydrogenase (NAD) activity mitochondrion|cytoplasm
YPL030W YPL030W TRM44 hom Verified 0.94924057946828 0.17124913356781 no 869 0.150347372477847 537 NA FT RNA PROCESSING tRNA(Ser) Um(44) 2'-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS(CGA) and tS(UGA); conserved among metazoans and fungi but there does not appear to be a homolog in plants; TRM44 is a non-essential gene tRNA methylation tRNA (uracil) methyltransferase activity cytoplasm
YPL096C-A YPL096C-A ERI1 hom Verified 0.948970107513622 0.171317907817921 no 870 0.207874427415474 722 NA FT LIPID METABOLISM|SIGNALING ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Endoplasmic reticulum membrane protein that binds to and inhibits GTP-bound Ras2p at the ER; component of the GPI-GnT complex which catalyzes the first step in GPI-anchor biosynthesis; probable homolog of mammalian PIG-Y protein GPI anchor biosynthetic process|Ras protein signal transduction GTPase inhibitor activity glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|endoplasmic reticulum membrane
YOR376W_d YOR376W YOR376W hom Dubious 0.948469923080228 0.171445138715797 no 871 0.151469495995583 481 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YOR376W is not an essential gene. Unknown Unknown Unknown
YOL048C YOL048C RRT8 hom Verified 0.947492523544293 0.171693932100806 no 872 0.16535667928126 580 NA Protein of unknown function; identified in a screen for mutants with increased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to lipid particles; protein abundance increases in response to DNA replication stress biological_process molecular_function integral to membrane|lipid particle
YOR192C YOR192C THI72 hom Verified 0.945910797858474 0.172097042785065 no 873 0.185891859878537 651 NA Transporter of thiamine or related compound; shares sequence similarity with Thi7p thiamine transport transporter activity integral to membrane|membrane
YCR050C_p YCR050C YCR050C hom Uncharacterized 0.944968605058264 0.17233745217778 no 874 0.146257683361577 551 NA Non-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein biological_process molecular_function cellular_component
YFR035C_p YFR035C YFR035C hom Uncharacterized 0.94375154927276 0.172648312414926 no 875 0.162646024675146 595 NA Putative protein of unknown function, deletion mutant exhibits synthetic phenotype with alpha-synuclein biological_process molecular_function cellular_component
YNL294C YNL294C RIM21 hom Verified 0.942394163010375 0.172995437265788 no 876 0.199483850469921 711 NA FF|FT ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS PLASMA MEMBRANE pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH fungal-type cell wall biogenesis|ascospore formation|invasive growth in response to glucose limitation molecular_function integral to membrane
YER080W YER080W AIM9 hom Verified 0.941995326858488 0.173097516231051 no 877 0.181345607405934 596 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss biological_process molecular_function mitochondrion
YOL115W YOL115W PAP2 hom Verified 0.940973740852117 0.173359158060414 no 878 0.189478996671422 674 NA FT CELL CYCLE|RNA PROCESSING|RESPONSE TO DNA DAMAGE|CELL DIVISION NUCLEUS Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Trf5p polyadenylation-dependent mRNA catabolic process|nuclear polyadenylation-dependent CUT catabolic process|base-excision repair|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent snRNA catabolic process|ncRNA polyadenylation|histone mRNA catabolic process|nuclear polyadenylation-dependent mRNA catabolic process|nuclear polyadenylation-dependent antisense transcript catabolic process|U4 snRNA 3'-end processing|nuclear mRNA surveillance of mRNA 3'-end processing|polyadenylation-dependent snoRNA 3'-end processing|snoRNA polyadenylation|tRNA modification 5'-deoxyribose-5-phosphate lyase activity|polynucleotide adenylyltransferase activity nucleolus|nucleus|TRAMP complex
YJL211C_d YJL211C YJL211C hom Dubious 0.939076383159963 0.173845764371318 no 879 0.172526386288099 575 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL210W/PEX2 Unknown Unknown Unknown
YDL059C YDL059C RAD59 hom Verified 0.938182691113019 0.174075265972928 no 880 0.193197291459663 683 NA FT RESPONSE TO DNA DAMAGE NUCLEUS Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p DNA strand renaturation|telomere maintenance via recombination|double-strand break repair via break-induced replication|double-strand break repair via single-strand annealing protein binding nucleus
YOR092W YOR092W ECM3 hom Verified 0.937559903023556 0.174235312808627 no 881 0.166754800435774 523 NA FT CELL WALL ORG/BIOGENESIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from ER to cytoplasm upon DNA replication stress; ECM3 has a paralog, YNL095C, that arose from the whole genome duplication fungal-type cell wall organization ATPase activity integral to membrane|endoplasmic reticulum
YPL003W YPL003W ULA1 hom Verified 0.936721675974589 0.174450871676027 no 882 0.178860221686617 608 NA Protein that acts together with Uba3p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation protein neddylation NEDD8 activating enzyme activity cellular_component
YLR406C-A_p YLR406C-A YLR406C-A hom Uncharacterized 0.93667014601645 0.174464128669228 no 883 0.177815798104019 603 NA Putative protein of unknown function biological_process molecular_function cellular_component
YJL075C_d YJL075C APQ13 hom Dubious 0.934115561040293 0.175122142921499 no 884 0.17491765895396 590 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene NET1; null mutant is sensitive to sorbate Unknown Unknown Unknown
YCR066W YCR066W RAD18 hom Verified 0.933651777462103 0.175241773697029 no 885 0.200577067533966 756 NA FF|FT RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME E3 ubiquitin ligase; forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; required for postreplication repair; SUMO-targeted ubiquitin ligase (STUbl) that contains a SUMO-interacting motif (SIM) which stimulates its ubiquitin ligase activity towards the sumoylated form of PCNA protein monoubiquitination|error-free translesion synthesis|error-free postreplication DNA repair|error-prone translesion synthesis ubiquitin-protein ligase activity|single-stranded DNA-dependent ATPase activity|single-stranded DNA binding nuclear chromatin|nucleus
YGL082W_p YGL082W YGL082W hom Uncharacterized 0.933396553185232 0.175307629691653 no 886 0.142709969641649 510 NA FT NUCLEUS Putative protein of unknown function; predicted prenylation/proteolysis target of Afc1p and Rce1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YGL082W is not an essential gene biological_process molecular_function nucleus|plasma membrane|cytoplasm
YNL201C YNL201C PSY2 hom Verified 0.933007111043001 0.175408148408438 no 887 0.205711187262629 701 NA FT CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Subunit of protein phosphatase PP4 complex; active complex is composed of catalytic subunit Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; Pph3p and Psy2p localize to foci on meiotic chromosomes; putative homolog of mammalian R3 Unknown|response to DNA damage stimulus|protein dephosphorylation|signal transduction involved in meiotic recombination checkpoint protein serine/threonine phosphatase activity condensed nuclear chromosome|nucleus
YGL023C YGL023C PIB2 hom Verified 0.932145335246913 0.175630710782741 no 888 0.189364891020292 640 NA FT VESICLE-MEDIATED TRANSPORT MITOCHONDRION Protein of unknown function; contains FYVE domain; similar to Fab1 and Vps27 biological_process molecular_function mitochondrion
YML094C-A_d YML094C-A YML094C-A hom Dubious 0.931436029597262 0.175814030379391 no 889 0.180941707179086 671 NA FF Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene GIM5/YML094W; deletion confers sensitivity to GSAO Unknown Unknown Unknown
YBR034C YBR034C HMT1 hom Verified 0.930402721773845 0.176081304936366 no 890 0.1949708534843 655 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA LOCALIZATION NUCLEUS Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs, including Npl3p and Hrp1p, affecting their activity and nuclear export; methylates U1 snRNP protein Snp1p and ribosomal protein Rps2p; interacts genetically with genes encoding components of Rpd3(L) and this interaction is important for Rpd3 recruitment to the subtelomeric region. mRNA export from nucleus|negative regulation of DNA-dependent transcription, termination|positive regulation of transcription elongation from RNA polymerase II promoter|peptidyl-arginine methylation protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity nucleus
YNL292W YNL292W PUS4 hom Verified 0.93029786719081 0.176108440904852 no 891 0.180518888407637 632 NA FT RNA PROCESSING NUCLEUS|MITOCHONDRION Pseudouridine synthase, catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs; PUS4 overexpression leads to translational derepression of GCN4 (Gcd- phenotype) tRNA modification pseudouridine synthase activity mitochondrion|nucleus
YDL160C YDL160C DHH1 hom Verified 0.929348344199 0.176354294373456 no 892 0.209705558938748 717 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION|RNA LOCALIZATION Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping; coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, may have a role in mRNA export and translation; C-terminus of Dhh1p interacts with Ngr1p and promotes POR1, but not EDC1 mRNA decay; forms cytoplasmic foci upon DNA replication stress deadenylation-dependent decapping of nuclear-transcribed mRNA|cell morphogenesis involved in conjugation with cellular fusion|stress granule assembly|cytoplasmic mRNA processing body assembly protein binding|RNA helicase activity cytoplasmic mRNA processing body|cytoplasmic stress granule|cytoplasm
YPR044C_d YPR044C OPI11 hom Dubious 0.927917563477271 0.176725166528295 no 893 0.175889966544231 623 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RPL43A/YPR043W; deletion confers sensitivity to GSAO Unknown Unknown Unknown
YIL090W YIL090W ICE2 hom Verified 0.926233429863318 0.17716234149515 no 894 0.187918822373849 638 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Integral ER membrane protein with type-III transmembrane domains; required for maintenance of ER zinc homeostasis; necessary for efficient targeting of Trm1p tRNA methyltransferase to inner nuclear membrane; mutations cause defects in cortical ER morphology in both the mother and daughter cells endoplasmic reticulum inheritance molecular_function integral to endoplasmic reticulum membrane|integral to membrane|endoplasmic reticulum
YER087C-A_d YER087C-A YER087C-A hom Dubious 0.926032576645554 0.177214525429586 no 895 0.165094563345219 535 NA Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; overlaps the uncharacterized gene YER087W, a putative tRNA synthetase Unknown Unknown Unknown
YCR049C_d YCR049C YCR049C hom Dubious 0.92502524519753 0.177476387930632 no 896 0.202227174992993 692 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YEL014C_d YEL014C YEL014C hom Dubious 0.924743559489794 0.177549657679839 no 897 0.152645328840398 516 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YCR010C YCR010C ADY2 hom Verified 0.924422994712765 0.177633063551991 no 898 0.195710969131694 651 NA FT CELL CYCLE|ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION|PLASMA MEMBRANE Acetate transporter required for normal sporulation; phosphorylated in mitochondria; ADY2 has a paralog, ATO2, that arose from the whole genome duplication nitrogen utilization|ammonium transport|acetate transport|transmembrane transport acetate transmembrane transporter activity|ammonium transmembrane transporter activity mitochondrion|integral to membrane|plasma membrane
YDR500C YDR500C RPL37B hom Verified 0.924188970936424 0.177693968438516 no 899 0.159201196549697 551 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L37B; protein abundance increases in response to DNA replication stress; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37B has a paralog, RPL37A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YDR222W_p YDR222W YDR222W hom Uncharacterized 0.923720866660841 0.177815832503447 no 900 0.208913738179676 716 NA FT RESPONSE TO OXIDATIVE STRESS Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern biological_process molecular_function cytoplasm
YOL082W YOL082W ATG19 hom Verified 0.92312124616377 0.177972011879175 no 901 0.148771944500135 459 NA FT PROTEIN LOCALIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; delivers cargo proteins aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p) to the phagophore assembly site for packaging into Cvt vesicles vesicle organization|ER-associated protein catabolic process|protein processing|protein complex localization|CVT pathway protein binding, bridging pre-autophagosomal structure|cytoplasm|CVT complex|extrinsic to membrane
YPL060W YPL060W MFM1 hom Verified 0.922866666246171 0.178038346858492 no 902 0.210753117933246 712 NA FT RNA PROCESSING|ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Mitochondrial inner membrane magnesium transporter, involved in maintenance of mitochondrial magnesium concentrations and membrane potential; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p mitochondrial magnesium ion transport magnesium ion transmembrane transporter activity integral to membrane|mitochondrial inner membrane
YPL116W YPL116W HOS3 hom Verified 0.922176679006631 0.178218212736254 no 903 0.153437017162974 528 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION NUCLEUS|SITE OF POLARIZED GROWTH Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) with specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats regulation of transcription involved in G1/S phase of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|histone deacetylation histone deacetylase activity nucleus|cellular bud neck|cytoplasm
YKL191W YKL191W DPH2 hom Verified 0.920368339105643 0.178690153959039 no 904 0.161391276690809 582 NA Protein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11p peptidyl-diphthamide biosynthetic process from peptidyl-histidine molecular_function cytoplasm
YDL011C_d YDL011C YDL011C hom Dubious 0.918755705818145 0.179111682714839 no 905 0.165189919146789 572 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized ORF YDL010W Unknown Unknown Unknown
YLR089C YLR089C ALT1 hom Verified 0.918722809517734 0.179120288036046 no 906 0.17336549207379 601 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Alanine transaminase (glutamic pyruvic transaminase); involved in alanine biosynthetic and catabolic processes; expression is induced in the presence of alanine; repression is mediated by Nrg1p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; paralogous gene ALT2 is catalytically inactive alanine catabolic process|alanine biosynthetic process L-alanine:2-oxoglutarate aminotransferase activity mitochondrion
YKR031C YKR031C SPO14 hom Verified 0.917867577347336 0.179344098915542 no 907 0.174062034063336 618 NA FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|LIPID METABOLISM NUCLEUS Phospholipase D; catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions phospholipid metabolic process|exocytosis|cell morphogenesis involved in conjugation with cellular fusion|ascospore-type prospore assembly phospholipase D activity|phosphatidylinositol-3-phosphate binding endosome|nucleus|prospore membrane
YMR279C YMR279C YMR279C hom Verified 0.917273374155395 0.179499703023216 no 908 0.198001264505567 666 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Putative boron transporter involved in boron efflux and resistance; overexpression mutant but not null mutant displays boron tolerance phenotype; identified as a heat-induced gene in a high-throughout screen; YMR279C is not an essential gene; YMR279C has a paralog, ATR1, that arose from the whole genome duplication borate transmembrane transport borate efflux transmembrane transporter activity integral to membrane
YHR116W YHR116W COX23 hom Verified 0.917213994030493 0.179515257570902 no 909 0.175586564334998 587 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs mitochondrial respiratory chain complex assembly molecular_function mitochondrion|cytoplasm
YBR041W YBR041W FAT1 hom Verified 0.914647859184318 0.180188262589289 no 910 0.219092247132125 720 NA FT KETONE METABOLISM|LIPID METABOLISM ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Very long chain fatty acyl-CoA synthetase and long chain fatty acid transporter; activates imported fatty acids with a preference for very long lengths (C20-C26); has a separate function in the transport of long chain fatty acids very long-chain fatty acid metabolic process|long-chain fatty acid transport very long-chain fatty acid-CoA ligase activity|long-chain fatty acid transporter activity intrinsic to internal side of plasma membrane|integral to membrane|endoplasmic reticulum|lipid particle|peroxisome
YHL039W YHL039W EFM1 hom Verified 0.914174870165349 0.180312483257436 no 911 0.183154346764786 677 NA Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm peptidyl-lysine monomethylation protein-lysine N-methyltransferase activity cytoplasm
YJR124C_p YJR124C YJR124C hom Uncharacterized 0.912658588876018 0.180711064953468 no 912 0.151570120993864 553 NA Putative protein of unknown function; expression induced under calcium shortage biological_process molecular_function integral to membrane
YPR120C YPR120C CLB5 hom Verified 0.912125293637583 0.180851382371327 no 913 0.200892714939186 675 NA FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION NUCLEUS B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase spindle assembly|G1/S transition of mitotic cell cycle|regulation of S phase of mitotic cell cycle|G2/M transition of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|positive regulation of spindle pole body separation|premeiotic DNA replication|positive regulation of DNA replication cyclin-dependent protein kinase regulator activity nucleus
YGL010W_p YGL010W YGL010W hom Uncharacterized 0.911133608342947 0.181112490118241 no 914 0.180165714178951 606 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Putative protein of unknown function; YGL010W is not an essential gene biological_process molecular_function integral to membrane|endoplasmic reticulum
YGR214W YGR214W RPS0A hom Verified 0.910827515241969 0.181193131180846 no 915 0.179102122037235 615 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION RIBOSOME Ribosomal 40S subunit protein S0A; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2; RPS0A has a paralog, RPS0B, that arose from the whole genome duplication; cytoplasmic translation|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA export from nucleus|ribosomal small subunit assembly|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit|90S preribosome
YIL160C YIL160C POT1 hom Verified 0.908667263899671 0.181762894550086 no 916 0.169639856449711 561 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids fatty acid beta-oxidation mRNA binding|acetyl-CoA C-acyltransferase activity peroxisomal matrix|peroxisome
YDR095C_d YDR095C YDR095C hom Dubious 0.908087438517836 0.181916013298022 no 917 0.186486973341353 585 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOR126C YOR126C IAH1 hom Verified 0.907671190691889 0.182025984645998 no 918 0.148039819213723 527 NA FT KETONE METABOLISM|LIPID METABOLISM Isoamyl acetate-hydrolyzing esterase, required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate, which is particularly important in sake brewing acetate metabolic process hydrolase activity, acting on ester bonds cellular_component
YDR452W YDR452W PPN1 hom Verified 0.907111630249963 0.182173884211063 no 919 0.227941885197169 667 NA FT NUCLEUS Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress polyphosphate catabolic process|polyphosphate metabolic process endopolyphosphatase activity|exopolyphosphatase activity fungal-type vacuole membrane|nucleus
YPL173W YPL173W MRPL40 hom Verified 0.906602323873239 0.182308566209263 no 920 0.199577856713718 691 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YCR086W YCR086W CSM1 hom Verified 0.90608507537844 0.182445412101772 no 921 0.180745844475245 625 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CHROMOSOME SEGREGATION ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME KINETOCHORE Nucleolar protein that forms a complex with Lrs4p and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation meiotic chromosome segregation|rDNA condensation|protein localization to nucleolar rDNA repeats|homologous chromosome segregation molecular_function nuclear envelope|nucleolus|monopolin complex
YJL105W YJL105W SET4 hom Verified 0.905271274346266 0.182660845302383 no 922 0.189935208473914 684 NA FT CHROMATIN ORGANIZATION Protein of unknown function, contains a SET domain; SET4 has a paralog, SET3, that arose from the whole genome duplication biological_process molecular_function cellular_component
YLR342W-A_p YLR342W-A YLR342W-A hom Uncharacterized 0.903233194355397 0.18320107199158 no 923 0.184537772500424 625 NA Putative protein of unknown function biological_process molecular_function cellular_component
YEL006W YEL006W YEA6 hom Verified 0.900283675731345 0.183984653054662 no 924 0.187833906917181 642 NA FT MITOCHONDRION Putative mitochondrial NAD+ transporter, member of the mitochondrial carrier subfamily (see also YIA6); has putative human ortholog transport|NAD transmembrane transport transporter activity|NAD transporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YKR016W YKR016W FCJ1 hom Verified 0.899708357668099 0.184137737253692 no 925 0.173344897218027 574 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial inner membrane protein, ortholog of mammalian mitofilin; involved in import of intermembrane space (IMS) proteins, probably by positioning Mia40p relative to the TOM complex to receive incoming proteins; also has an essential role in the maintenance of crista junctions and inner membrane architecture, as a component of the mitochondrial inner membrane organizing system (MICOS, MitOS or MINOS), a scaffold-like structure on the IMS side of the inner membrane cristae formation|protein import into mitochondrial intermembrane space molecular_function mitochondrion|mitochondrial inner membrane|mitochondrial crista|mitochondrial crista junction|integral to mitochondrial inner membrane
YJR010C-A YJR010C-A SPC1 hom Verified 0.899460675140956 0.184203666563785 no 926 0.187114463737097 660 NA FT PROTEIN LOCALIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Subunit of the signal peptidase complex (SPC); SPC cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER); homolog of the SPC12 subunit of mammalian signal peptidase complex; protein abundance increases in response to DNA replication stress signal peptide processing|protein targeting to ER molecular_function signal peptidase complex
YML122C_d YML122C YML122C hom Dubious 0.899096170595934 0.184300718828547 no 927 0.287951994358722 968 NA FF Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YJL064W_d YJL064W YJL064W hom Dubious 0.898652323008188 0.18441893976801 no 928 0.17688895713029 640 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL065C/DLS1 Unknown Unknown Unknown
YML103C YML103C NUP188 hom Verified 0.898314729752759 0.184508890934348 no 929 0.169941475684828 589 NA FT PROTEIN LOCALIZATION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188 nuclear pore organization|protein import into nucleus|mRNA export from nucleus in response to heat stress structural constituent of nuclear pore integral to membrane|nuclear pore|nuclear pore inner ring
YGR127W_p YGR127W YGR127W hom Uncharacterized 0.897638833443199 0.184689064382725 no 930 0.163011280030306 565 NA Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response biological_process molecular_function cellular_component
YDR448W YDR448W ADA2 hom Verified 0.897181141224488 0.184811133335173 no 931 0.249045417486724 871 NA FF|FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS HISTONE ACETYLTRANSFERASE Transcription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes chromatin silencing at rDNA|chromatin modification|regulation of transcription from RNA polymerase II promoter|positive regulation of histone acetylation|chromatin silencing at telomere chromatin binding|transcription coactivator activity|histone acetyltransferase activity|phosphatidylserine binding SLIK (SAGA-like) complex|Ada2/Gcn5/Ada3 transcription activator complex|SAGA complex
YLR324W YLR324W PEX30 hom Verified 0.896441536359683 0.185008495857159 no 932 0.217818220093486 746 NA FF|FT PEROXISOME ORGANIZATION Peroxisomal integral membrane protein, involved in negative regulation of peroxisome number; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p peroxisome organization molecular_function integral to membrane|peroxisome|integral to peroxisomal membrane
YBR097W YBR097W VPS15 hom Verified 0.895919705301637 0.185147824503403 no 933 0.178216187375941 600 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|PROTEIN PHOSPHORYLATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION ENDOMEMBRANE SYSTEM|MITOCHONDRION|GOLGI APPARATUS Serine/threonine protein kinase involved in vacuolar protein sorting; functions as a membrane-associated complex with Vps34p; active form recruits Vps34p to the Golgi membrane; interacts with the GDP-bound form of Gpa1p; myristoylated; a fraction is localized, with Vps34p, to nuclear pores at nucleus-vacuole junctions and may facilitate transcription elongation for genes positioned at the nuclear periphery protein retention in Golgi apparatus|vacuole inheritance|peroxisome degradation|protein phosphorylation|macroautophagy|inositol lipid-mediated signaling|late endosome to vacuole transport|protein targeting to vacuole ubiquitin binding|protein serine/threonine kinase activity mitochondrion|phosphatidylinositol 3-kinase complex I|phosphatidylinositol 3-kinase complex II|Golgi membrane
YLR139C YLR139C SLS1 hom Verified 0.894734150132437 0.185464609323523 no 934 0.215640510651742 730 NA FT TRANSLATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Mitochondrial membrane protein that coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translation machinery aerobic respiration|mitochondrial translation molecular_function mitochondrial nucleoid|mitochondrion|integral to membrane|mitochondrial inner membrane
YAL047C YAL047C SPC72 hom Verified 0.894041433908302 0.185649861336035 no 935 0.192312503029903 634 NA FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION NUCLEUS|CYTOSKELETON Component of the cytoplasmic Tub4p (gamma-tubulin) complex, binds spindle pole bodies and links them to microtubules; has roles in astral microtubule formation and stabilization microtubule nucleation|nuclear migration along microtubule|mitotic cell cycle spindle orientation checkpoint|mitotic spindle elongation|mitotic sister chromatid segregation structural constituent of cytoskeleton outer plaque of spindle pole body
YLR318W YLR318W EST2 hom Verified 0.893256951645843 0.185859792772352 no 936 0.181697762108655 660 NA FT NUCLEUS|CHROMOSOME Reverse transcriptase subunit of the telomerase holoenzyme, essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia telomere maintenance via telomerase|replicative cell aging telomerase activity|telomeric template RNA reverse transcriptase activity|telomeric DNA binding telomerase catalytic core complex|nucleolus|nucleus|telomerase holoenzyme complex
YLR072W_p YLR072W YLR072W hom Uncharacterized 0.892800692854389 0.185981957626976 no 937 0.19010327462602 632 NA FT ENDOMEMBRANE SYSTEM Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YLR072W is not an esssential gene biological_process molecular_function cytoplasm
YKL027W YKL027W YKL027W hom Verified 0.891500725810047 0.186330301175417 no 938 0.190220931361258 666 NA FT MITOCHONDRION Protein of unknown function, localized to the mitochondrial outer membrane biological_process molecular_function mitochondrial outer membrane|mitochondrion
YDR266C YDR266C HEL2 hom Verified 0.890999860791531 0.186464622458164 no 939 0.192867559576465 613 NA RING finger ubiquitin ligase (E3); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; computational analysis suggests a role as a transcription factor biological_process molecular_function ribosome|cytoplasm
YGR262C YGR262C BUD32 hom Verified 0.8904506758181 0.186611971031219 no 940 0.222872410499012 684 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|LIPID METABOLISM|CELL DIVISION|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION NUCLEUS|CHROMOSOME Protein kinase, component of the EKC/KEOPS complex with Kae1p, Cgi121p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription threonylcarbamoyladenosine metabolic process|protein phosphorylation|telomere maintenance|cellular bud site selection|positive regulation of transcription from RNA polymerase II promoter protein serine/threonine kinase activity EKC/KEOPS complex|nucleus|cytoplasm
YNL285W_d YNL285W YNL285W hom Dubious 0.890003712109326 0.186731946421352 no 941 0.178612804306096 595 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YIL041W YIL041W GVP36 hom Verified 0.889865070396058 0.186769170761757 no 942 0.205738561216929 674 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION ENDOMEMBRANE SYSTEM|GOLGI APPARATUS BAR domain-containing protein that localizes to both early and late Golgi vesicles; required for adaptation to varying nutrient concentrations, fluid-phase endocytosis, polarization of the actin cytoskeleton, and vacuole biogenesis vacuole organization|endocytosis|establishment or maintenance of actin cytoskeleton polarity molecular_function integral to Golgi membrane|cytoplasm
YGL115W YGL115W SNF4 hom Verified 0.888569468530927 0.187117252872685 no 943 0.203269117150716 713 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|PLASMA MEMBRANE Activating gamma subunit of the AMP-activated Snf1p kinase complex; additional subunits of the complex are Snf1p and a Sip1p/Sip2p/Gal83p family member; activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis; protein abundance increases in response to DNA replication stress positive regulation of gluconeogenesis|peroxisome organization|protein phosphorylation|replicative cell aging|regulation of transcription from RNA polymerase II promoter AMP-activated protein kinase activity|protein serine/threonine kinase activator activity AMP-activated protein kinase complex|plasma membrane|nucleus|nuclear envelope lumen|cytoplasm
YHR016C YHR016C YSC84 hom Verified 0.88745118625097 0.187418017922152 no 944 0.192834845550612 640 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION CYTOSKELETON Actin-binding protein; involved in bundling of actin filaments and endocytosis of actin cortical patches; activity stimulated by Las17p; contains SH3 domain similar to Rvs167p; YSC84 has a paralog, LSB3, that arose from the whole genome duplication endocytosis|actin filament organization|actin filament bundle assembly|actin cortical patch localization|actin cytoskeleton organization actin filament binding actin cortical patch
YDL067C YDL067C COX9 hom Verified 0.887300056237406 0.187458687657123 no 945 0.191837494853122 676 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain mitochondrial electron transport, cytochrome c to oxygen cytochrome-c oxidase activity mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YGL223C YGL223C COG1 hom Verified 0.886191296632274 0.187757226396666 no 946 0.246948807749174 828 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments retrograde transport, vesicle recycling within Golgi|intra-Golgi vesicle-mediated transport|CVT pathway molecular_function Golgi transport complex
YMR294W YMR294W JNM1 hom Verified 0.886166251623278 0.187763973272936 no 947 0.22297477444206 798 NA FF|FT CELL CYCLE|CYTOSKELETON ORGANIZATION CYTOSKELETON Component of the yeast dynactin complex, consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B nuclear migration|establishment of mitotic spindle orientation structural constituent of cytoskeleton dynactin complex|cell cortex|spindle pole body|astral microtubule
YNL327W YNL327W EGT2 hom Verified 0.885291112664218 0.187999821028859 no 948 0.190351012592915 628 NA FT CELL CYCLE|CELL DIVISION Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis, expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner cytokinesis cellulase activity fungal-type cell wall|cellular bud|cell septum
YJL096W YJL096W MRPL49 hom Verified 0.884566691787985 0.188195188924481 no 949 0.212962411154912 717 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YCR079W YCR079W PTC6 hom Verified 0.883747220453403 0.188416341780268 no 950 0.204511548194346 734 NA FT RESPONSE TO NUTRIENT LEVELS MITOCHONDRION Mitochondrial type 2C protein phosphatase (PP2C) with similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase mitochondrion degradation|positive regulation of catalytic activity|macroautophagy|protein dephosphorylation protein serine/threonine phosphatase activity mitochondrion|mitochondrial matrix|mitochondrial intermembrane space
YPL111W YPL111W CAR1 hom Verified 0.883128410932207 0.188583447686642 no 951 0.200331931460373 690 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS|SITE OF POLARIZED GROWTH Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance regulation of ornithine metabolic process|arginine catabolic process to ornithine manganese ion binding|arginase activity|ornithine carbamoyltransferase inhibitor activity|zinc ion binding cytosol|nucleus|mating projection tip|cytoplasm
YMR052C-A_d YMR052C-A YMR052C-A hom Dubious 0.88289928801719 0.188645344168581 no 952 0.188174616739144 694 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YKL080W YKL080W VMA5 hom Verified 0.882203260189849 0.188833449621992 no 953 0.253299359538502 848 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane vacuolar acidification proton-transporting ATPase activity, rotational mechanism fungal-type vacuole membrane|vacuolar proton-transporting V-type ATPase, V1 domain|integral to membrane
YOR296W_p YOR296W YOR296W hom Uncharacterized 0.881769990364626 0.188950601588182 no 954 0.147002870645922 516 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; expressed during copper starvation; YOR296W is not an essential gene biological_process molecular_function cytoplasm
YMR257C YMR257C PET111 hom Verified 0.881319041982847 0.189072581207748 no 955 0.210708420689069 755 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membrane mitochondrial respiratory chain complex IV biogenesis|positive regulation of mitochondrial translation translation regulator activity mitochondrion|mitochondrial inner membrane
YDR409W YDR409W SIZ1 hom Verified 0.8812364536318 0.189094926258964 no 956 0.189225897107906 637 NA FT CHROMOSOME SEGREGATION NUCLEUS|SITE OF POLARIZED GROWTH|CHROMOSOME|CYTOSKELETON SUMO/Smt3 ligase that promotes the attachment of sumo (Smt3p; small ubiquitin-related modifier) to proteins; binds Ubc9p and may bind septins; specifically required for sumoylation of septins in vivo; localized to the septin ring protein sumoylation|chromosome segregation SUMO ligase activity nuclear chromatin|septin ring
YDR392W YDR392W SPT3 hom Verified 0.880519336237003 0.189289017446376 no 957 0.249911166598341 868 NA FF|FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS HISTONE ACETYLTRANSFERASE Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters conjugation with cellular fusion|histone acetylation|pseudohyphal growth|ascospore formation|chromatin modification|invasive growth in response to glucose limitation|transcription from RNA polymerase II promoter transcription cofactor activity SLIK (SAGA-like) complex|SAGA complex
YKL075C_p YKL075C YKL075C hom Uncharacterized 0.880339207270055 0.189337789461735 no 958 0.199723225839414 634 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; proposed to be involved in resistance to streptozotocin and camptothecin response to drug molecular_function cytoplasm
YDR138W YDR138W HPR1 hom Verified 0.880224180763172 0.189368938274552 no 959 0.254272575054068 863 NA FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION NUCLEUS RNA POL II, HOLOENZYME Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p mRNA 3'-end processing|mRNA export from nucleus|transcription-coupled nucleotide-excision repair|DNA recombination|response to DNA damage stimulus|transcription elongation from RNA polymerase II promoter protein complex scaffold|nucleic acid binding THO complex part of transcription export complex|Cdc73/Paf1 complex|nucleoplasmic THO complex
YOR185C YOR185C GSP2 hom Verified 0.880155038028586 0.189387663425256 no 960 0.208406685879011 699 NA FT PROTEIN LOCALIZATION|SIGNALING|NUCLEOTIDE METABOLISM NUCLEUS GTP binding protein (mammalian Ranp homolog); involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas); Gsp1p homolog that is not required for viability; protein abundance increases in response to DNA replication stress nucleus organization GTPase activity integral to membrane|nucleus
YPR195C_d YPR195C YPR195C hom Dubious 0.879159866354804 0.189657300826914 no 961 0.179945464687486 602 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGL242C_p YGL242C YGL242C hom Uncharacterized 0.878334312936002 0.189881160010318 no 962 0.212593613636625 693 NA Putative protein of unknown function; deletion mutant is viable biological_process molecular_function cellular_component
YDL214C YDL214C PRR2 hom Verified 0.877784785654933 0.190030261259152 no 963 0.182303503293019 606 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN PHOSPHORYLATION NUCLEUS Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor; mutant has increased aneuploidy tolerance negative regulation of transcription from RNA polymerase II promoter by pheromones|negative regulation of conjugation with cellular fusion|protein phosphorylation protein kinase activity|receptor signaling protein serine/threonine kinase activity nucleus
YDL175C YDL175C AIR2 hom Verified 0.876847795143828 0.190284657403877 no 964 0.199774660690556 672 NA FT RNA PROCESSING NUCLEUS RNA-binding subunit of the TRAMP nuclear RNA surveillance complex; involved in nuclear RNA processing and degradation; involved in TRAMP complex assembly as a bridge between Mtr4p and Trf4p; stimulates the poly(A) polymerase activity of Pap2p in vitro; has 5 zinc knuckle motifs; AIR2 has a paralog, AIR1, that arose from the whole genome duplication nuclear polyadenylation-dependent CUT catabolic process|nuclear mRNA surveillance of mRNA 3'-end processing|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent snRNA catabolic process|ncRNA polyadenylation|tRNA modification polynucleotide adenylyltransferase activity|RNA binding|protein binding, bridging nucleolus|TRAMP complex
YPR061C YPR061C JID1 hom Verified 0.87679426618852 0.190299197013671 no 965 0.184279840390841 679 NA FT MITOCHONDRION Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae biological_process molecular_function mitochondrion
YMR031C YMR031C EIS1 hom Verified 0.875746661924172 0.190583886104752 no 966 0.201427160508137 654 NA FT PROTEIN COMPLEX ORG/BIOGENESIS MITOCHONDRION|PLASMA MEMBRANE Component of the eisosome required for proper eisosome assembly; similarity to Ykl050cp and Uso1p; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress eisosome assembly molecular_function eisosome|mitochondrion|membrane raft|cytoplasm
YAL027W YAL027W SAW1 hom Verified 0.875689512564071 0.19059942410381 no 967 0.148220019390154 534 NA FT RESPONSE TO DNA DAMAGE NUCLEUS 5'- and 3'-flap DNA binding protein; stimulates the endonuclease activity of Rad1/Rad10p; involved in Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during double-strand break repair via single-strand annealing; green fluorescent protein (GFP)-fusion protein localizes to the nucleus double-strand break repair via single-strand annealing, removal of nonhomologous ends molecular_function nucleus
YIL121W YIL121W QDR2 hom Verified 0.875643142403006 0.190612031982106 no 968 0.172202401570213 576 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; exports copper; has broad substrate specificity and can transport many mono- and divalent cations; transports a variety of drugs and is required for resistance to quinidine, barban, cisplatin, and bleomycin; contributes to potassium homeostasis; expression is regulated by copper drug transmembrane transport|potassium ion import drug transmembrane transporter activity integral to membrane|integral to plasma membrane
YKR098C YKR098C UBP11 hom Verified 0.875222090202454 0.190726537973708 no 969 0.191638094362028 681 NA FT PROTEOLYSIS Ubiquitin-specific protease that cleaves ubiquitin from ubiquitinated proteins biological_process ubiquitin-specific protease activity cellular_component
YLR385C YLR385C SWC7 hom Verified 0.873766056780076 0.191122834481114 no 970 0.183873245091525 598 NA FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin chromatin remodeling molecular_function Swr1 complex|nucleus
YNL027W YNL027W CRZ1 hom Verified 0.872651323519604 0.191426578460413 no 971 0.178664156805117 569 NA FT TRANSCRIPTION FROM RNA POL II|SIGNALING|ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|ION HOMEOSTASIS NUCLEUS Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress regulation of potassium ion concentration by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter in response to calcium ion|positive regulation of sodium ion transport by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter in response to increased salt|cell wall chitin biosynthetic process|positive regulation of transcription from RNA polymerase II promoter in response to alkalinity|positive regulation of transcription from RNA polymerase II promoter by pheromones|ion homeostasis|Unknown|positive regulation of transcription from RNA polymerase II promoter core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus|cytoplasm
YIR043C YIR043C YIR043C hom pseudogene 0.872517216737236 0.191463139975189 no 972 0.192472517940365 633 NA Possible pseudogene in strain S288C; YIR043C and the adjacent ORF, YIR044C, together may encode a non-functional member of the conserved, often subtelomerically-encoded Cos protein family biological_process molecular_function cellular_component
YIL108W YIL108W YIL108W hom Verified 0.872130943186896 0.191568473591685 no 973 0.159015971116471 531 NA FT PROTEOLYSIS Putative metalloendopeptidase; forms cytoplasmic foci upon DNA replication stress biological_process molecular_function cytoplasm
YKL079W YKL079W SMY1 hom Verified 0.871086771439157 0.1918533882583 no 974 0.167890351830998 557 NA FT VESICLE-MEDIATED TRANSPORT SITE OF POLARIZED GROWTH|CYTOSKELETON Protein that interacts with Myo2p, proposed to be involved in exocytosis; N-terminal domain is related to the motor domain of kinesins exocytosis motor activity incipient cellular bud site|cellular bud neck|mating projection tip|cellular bud tip
YEL033W_p YEL033W MTC7 hom Uncharacterized 0.870442070567319 0.192029432012719 no 975 0.23800805441021 807 NA Predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant biological_process molecular_function cellular_component
YML076C YML076C WAR1 hom Verified 0.86906903523298 0.192404686049239 no 976 0.166610494354473 565 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS|MITOCHONDRION Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively response to acid sequence-specific DNA binding transcription factor activity mitochondrion|nucleus
YLR354C YLR354C TAL1 hom Verified 0.868838921725597 0.192467620495898 no 977 0.224551895837757 736 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS NUCLEUS Transaldolase, enzyme in the non-oxidative pentose phosphate pathway; converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate pentose-phosphate shunt sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity nucleus|cytoplasm
YHL010C YHL010C ETP1 hom Verified 0.868616058107226 0.192528584143646 no 978 0.143045528490813 486 NA Putative protein of unknown function that is required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences response to ethanol ubiquitin binding|nuclear localization sequence binding cellular_component
YAL009W YAL009W SPO7 hom Verified 0.868054481140966 0.192682254110551 no 979 0.221691574966189 776 NA FF|FT CELL CYCLE|LIPID METABOLISM|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology, premeiotic replication, and sporulation negative regulation of phospholipid biosynthetic process|nuclear envelope organization phosphoprotein phosphatase activity Nem1-Spo7 phosphatase complex|integral to membrane
YJL210W YJL210W PEX2 hom Verified 0.867489662937905 0.192836886588887 no 980 0.182633496154013 604 NA FT PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION RING-finger peroxin and E3 ubiquitin ligase, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import protein import into peroxisome matrix ubiquitin-protein ligase activity|protein binding peroxisomal membrane
YDL243C YDL243C AAD4 hom Verified 0.866934865440998 0.192988849439143 no 981 0.183878736124452 613 NA FT OXIDATION-REDUCTION PROCESS Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin cellular aldehyde metabolic process aryl-alcohol dehydrogenase (NAD+) activity cellular_component
YLR082C YLR082C SRL2 hom Verified 0.866844867786664 0.193013507307516 no 982 0.191411048909555 604 NA FT NUCLEUS Protein of unknown function; overexpression suppresses the lethality caused by a rad53 null mutation nucleobase-containing compound metabolic process molecular_function nucleus|cytoplasm
YFR010W YFR010W UBP6 hom Verified 0.866748921811129 0.193039797036145 no 983 0.239732084726226 817 NA FT PROTEOLYSIS Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains; works in opposition to Hul5p polyubiquitin elongation activity; mutant has aneuploidy tolerance protein deubiquitination ubiquitin-specific protease activity proteasome complex|proteasome regulatory particle
YPL105C YPL105C SYH1 hom Verified 0.866656047336101 0.193065247239133 no 984 0.188277135493121 688 NA FT PROTEIN LOCALIZATION MITOCHONDRION Protein of unknown function that influences nuclear pore distribution; co-purifies with ribosomes; contains a GYF domain, which bind proline-rich sequences; deletion extends chronological lifespan; SYH1 has a paralog, SMY2, that arose from the whole genome duplication nuclear pore distribution molecular_function mitochondrion|ribosome|cytoplasmic mRNA processing body|extrinsic to membrane|cytoplasm
YMR204C YMR204C INP1 hom Verified 0.866181172117945 0.193195408341437 no 985 0.179556958915179 588 NA FT PEROXISOME ORGANIZATION Peripheral membrane protein of peroxisomes involved in peroxisomal inheritance; recruitment to peroxisomes is mediated by interaction with Pex3p at the peroxisomal membrane peroxisome inheritance molecular_function peroxisome|extrinsic to intraperoxisomal membrane
YHR076W YHR076W PTC7 hom Verified 0.865653601146998 0.193340075898762 no 986 0.211394644871648 718 NA FT ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION Type 2C protein phosphatase (PP2C); alternatively spliced to create two mRNA isoforms; protein from spliced form localizes to the mitochondria while the one from the unspliced form is localized to the nuclear envelope biological_process protein serine/threonine phosphatase activity nuclear envelope|mitochondrion
YHR095W_d YHR095W YHR095W hom Dubious 0.865554626261293 0.193367223599735 no 987 0.192699452653967 637 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOR136W YOR136W IDH2 hom Verified 0.864652853622017 0.193614676841807 no 988 0.223656968544826 779 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylated glutamate biosynthetic process|isocitrate metabolic process|tricarboxylic acid cycle isocitrate dehydrogenase (NAD+) activity mitochondrial isocitrate dehydrogenase complex (NAD+)|mitochondrion|mitochondrial matrix
YLR025W YLR025W SNF7 hom Verified 0.864209111441127 0.193736513919444 no 989 0.271215728523922 951 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes cellular response to anoxia|intralumenal vesicle formation|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|late endosome to vacuole transport protein binding ESCRT III complex|cytoplasm
YAL049C YAL049C AIM2 hom Verified 0.863542500505428 0.193919631292297 no 990 0.18341077025194 653 NA Cytoplasmic protein involved in mitochondrial function or organization; null mutant displays reduced frequency of mitochondrial genome loss; potential Hsp82p interactor biological_process molecular_function cytoplasm
YPL230W YPL230W USV1 hom Verified 0.86317833917931 0.194019710588239 no 991 0.165688708592341 560 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS NUCLEUS Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in growth on non-fermentable carbon sources, response to salt stress and cell wall biosynthesis; USV1 has a paralog, RGM1, that arose from the whole genome duplication carbon catabolite activation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter in response to salt stress sequence-specific DNA binding nucleus
YPL260W YPL260W YPL260W hom Verified 0.86220570357662 0.194287165820909 no 992 0.218882373359997 751 NA FT NUCLEUS Putative substrate of cAMP-dependent protein kinase (PKA); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YPL260W is not an essential gene; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus|cytoplasm
YNL213C YNL213C RRG9 hom Verified 0.860777821386126 0.194680211193198 no 993 0.213367147005489 751 NA FT MITOCHONDRION ORGANIZATION MITOCHONDRION Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies mitochondrion organization|mitochondrial genome maintenance molecular_function mitochondrion
YJR052W YJR052W RAD7 hom Verified 0.860182359310933 0.194844263639484 no 994 0.192131976263182 644 NA FT RESPONSE TO DNA DAMAGE|PROTEOLYSIS NUCLEUS UBIQUITIN LIGASE COMPLEX Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex nucleotide-excision repair, DNA damage recognition|protein ubiquitination involved in ubiquitin-dependent protein catabolic process damaged DNA binding|ubiquitin-protein ligase activity|DNA-dependent ATPase activity nucleotide-excision repair factor 4 complex|Cul3-RING ubiquitin ligase complex
YPL156C YPL156C PRM4 hom Verified 0.859492544595852 0.195034415738376 no 995 0.167524290096184 627 NA Pheromone-regulated protein proposed to be involved in mating; predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift biological_process molecular_function integral to membrane
YPL051W YPL051W ARL3 hom Verified 0.859280365221806 0.195092927099802 no 996 0.236384645285875 825 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING ENDOMEMBRANE SYSTEM|GOLGI APPARATUS GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor intracellular protein transport|Golgi to plasma membrane protein transport|protein localization to organelle GTPase activity Golgi apparatus|nuclear outer membrane-endoplasmic reticulum membrane network
YGR250C YGR250C YGR250C hom Verified 0.858121100581343 0.195412798528645 no 997 0.200616081288863 675 NA Putative RNA binding protein; localizes to stress granules induced by glucose deprivation; interacts with Rbg1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress biological_process RNA binding cytoplasmic stress granule|cytoplasm
YOR061W YOR061W CKA2 hom Verified 0.857815450034649 0.195497188547125 no 998 0.217105799628791 800 NA FF|FT RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION NUCLEUS Alpha' catalytic subunit of casein kinase 2 (CK2); CK2 is a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; protein abundance increases in response to DNA replication stress; regulates Fkh1p-mediated donor preference during mating-type switching regulation of transcription from RNA polymerase I promoter|chronological cell aging|protein phosphorylation|regulation of transcription from RNA polymerase III promoter|response to DNA damage stimulus protein serine/threonine kinase activity protein kinase CK2 complex|UTP-C complex
YNL275W YNL275W BOR1 hom Verified 0.857271807601322 0.19564734273194 no 999 0.189715448109435 629 NA FT PROTEIN LOCALIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT PLASMA MEMBRANE Boron efflux transporter of the plasma membrane; binds HCO3-, I-, Br-, NO3- and Cl-; has similarity to the characterized boron efflux transporter A. thaliana BOR1 borate transport|protein targeting to vacuole borate efflux transmembrane transporter activity integral to membrane|plasma membrane|fungal-type vacuole
YOR367W YOR367W SCP1 hom Verified 0.857253648465238 0.195652359498296 no 1000 0.214695928455748 752 NA FT CYTOSKELETON ORGANIZATION CYTOSKELETON Component of yeast cortical actin cytoskeleton, binds and cross links actin filaments; originally identified by its homology to calponin (contains a calponin-like repeat) but the Scp1p domain structure is more similar to transgelin actin filament organization|chronological cell aging actin filament binding|protein binding, bridging actin cortical patch
YFR006W_p YFR006W YFR006W hom Uncharacterized 0.855227685742562 0.196212556027028 no 1001 0.188658671162607 632 NA Putative X-Pro aminopeptidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YFR006W is not an essential gene biological_process molecular_function cytoplasm
YBR047W_p YBR047W FMP23 hom Uncharacterized 0.853985539115355 0.196556500948074 no 1002 0.190630814944841 660 NA FT MITOCHONDRION Putative protein of unknown function; proposed to be involved in iron or copper homeostasis; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YMR062C YMR062C ARG7 hom Verified 0.853560928555948 0.196674157466089 no 1003 0.239958668906605 824 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS MITOCHONDRION Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine fungal-type cell wall organization|ornithine biosynthetic process|arginine biosynthetic process acetyl-CoA:L-glutamate N-acetyltransferase activity|glutamate N-acetyltransferase activity mitochondrion|mitochondrial matrix
YNR069C YNR069C BSC5 hom Verified 0.852165833719719 0.197061028404971 no 1004 0.206671921811619 693 NA Protein of unknown function; shows homology with N-terminal end of Bul1p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough expression includes YNR068C and the locus for this readthrough is termed BUL3; Bul3p is involved in ubiquitin-mediated sorting of plasma membrane proteins; readthrough and shortened forms of Bul3p interact with Rsp5p differently in vitro biological_process molecular_function cellular_component
YDR056C_p YDR056C YDR056C hom Uncharacterized 0.851952326122071 0.197120276376679 no 1005 0.18797472600195 650 NA FT ENDOPLASMIC RETICULUM Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR056C is not an essential protein biological_process molecular_function endoplasmic reticulum
YJL142C_d YJL142C IRC9 hom Dubious 0.851794523920869 0.197164073128618 no 1006 0.171482933673788 594 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene YJL141C; null mutant displays increased levels of spontaneous Rad52p foci Unknown Unknown Unknown
YDR003W YDR003W RCR2 hom Verified 0.851493532429473 0.197247627258757 no 1007 0.176049452990511 603 NA FT VESICLE-MEDIATED TRANSPORT Vacuolar protein; presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR2 has a paralog, RCR1, that arose from the whole genome duplication vesicle-mediated transport molecular_function vesicle|integral to membrane|fungal-type vacuole|cytoplasm
YLR133W YLR133W CKI1 hom Verified 0.850887768595065 0.197415849992725 no 1008 0.243213627974734 822 NA FT LIPID METABOLISM Choline kinase; catalyzes the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; CKI1 has a paralog, EKI1, that arose from the whole genome duplication phosphatidylethanolamine biosynthetic process|phosphatidylcholine biosynthetic process ethanolamine kinase activity|choline kinase activity cytoplasm
YLR444C_d YLR444C YLR444C hom Dubious 0.850354713298739 0.197563953052311 no 1009 0.183276827785731 637 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR455W YLR455W YLR455W hom Verified 0.849943348051378 0.197678291887352 no 1010 0.213540104766429 744 NA FT NUCLEUS Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus
YGL166W YGL166W CUP2 hom Verified 0.849599698463935 0.197773839830271 no 1011 0.207112919118596 668 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations; CUP2 has a paralog, HAA1, that arose from the whole genome duplication regulation of transcription from RNA polymerase II promoter|response to copper ion RNA polymerase II core promoter proximal region sequence-specific DNA binding|copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity|copper ion binding nucleus
YML131W YML131W YML131W hom Verified 0.849398212203498 0.197829873817498 no 1012 0.168240376718625 566 NA FT OXIDATION-REDUCTION PROCESS Protein of unknown function; similar to medium chain dehydrogenase/reductases; expression induced by stresses including osmotic shock, DNA damaging agents, and other chemicals; GFP-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress biological_process molecular_function cytoplasm
YBR217W YBR217W ATG12 hom Verified 0.84842564577223 0.198100482582755 no 1013 0.205565481001391 697 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Conserved ubiquitin-like modifier involved in autophagy and the Cvt pathway; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg12p-Atg5p also forms a complex with Atg16p that is required for autophagosome formation C-terminal protein lipidation|piecemeal microautophagy of nucleus|mitochondrion degradation|CVT pathway|autophagic vacuole assembly Atg8 ligase activity|protein tag Atg12-Atg5-Atg16 complex|pre-autophagosomal structure
YKR050W YKR050W TRK2 hom Verified 0.848266078604285 0.198144902193918 no 1014 0.2129721414978 685 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Component of the Trk1p-Trk2p potassium transport system; TRK2 has a paralog, TRK1, that arose from the whole genome duplication cellular potassium ion homeostasis potassium ion transmembrane transporter activity integral to membrane|plasma membrane
YGR231C YGR231C PHB2 hom Verified 0.848255225369056 0.198147923688529 no 1015 0.213324608208607 716 NA FT PROTEOLYSIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation mitochondrion inheritance|protein folding|negative regulation of proteolysis|replicative cell aging molecular_function mitochondrion|mitochondrial inner membrane
YPR089W_p YPR089W YPR089W hom Uncharacterized 0.847660548538938 0.198313521709126 no 1016 0.204142884566633 731 NA FT GOLGI APPARATUS Protein of unknown function; exhibits genetic interaction with ERG11 and protein-protein interaction with Hsp82p biological_process molecular_function cellular_component
YPL249C YPL249C GYP5 hom Verified 0.847475032989723 0.198365198801109 no 1017 0.181115023159069 576 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM GOLGI APPARATUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress vesicle-mediated transport|ER to Golgi vesicle-mediated transport Rab GTPase activator activity cytosol|incipient cellular bud site|plasma membrane|cellular bud neck|Golgi-associated vesicle|cellular bud tip
YNR063W_p YNR063W YNR063W hom Uncharacterized 0.846302916772983 0.198691890565228 no 1018 0.181019729680283 624 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Putative zinc-cluster protein of unknown function biological_process sequence-specific DNA binding cellular_component
YFR016C YFR016C YFR016C hom Verified 0.846211392778349 0.19871741374513 no 1019 0.153845849175869 518 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and bud; interacts with Spa2p; YFL016C is not an essential gene biological_process molecular_function cellular bud|cytoplasm
YOL056W YOL056W GPM3 hom Verified 0.844121750474671 0.199300687321017 no 1020 0.195848209147457 686 NA FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event biological_process phosphoglycerate mutase activity|molecular_function cytosol
YHR129C YHR129C ARP1 hom Verified 0.84370072733094 0.1994183305052 no 1021 0.18634195995104 689 NA FT CELL CYCLE|CYTOSKELETON ORGANIZATION CYTOSKELETON Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; putative ortholog of mammalian centractin nuclear migration|establishment of mitotic spindle orientation structural constituent of cytoskeleton cell cortex|dynactin complex|spindle pole body|astral microtubule
YBR144C_d YBR144C YBR144C hom Dubious 0.843491869185969 0.19947670560341 no 1022 0.173115707378793 603 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR144C is not an essential gene Unknown Unknown Unknown
YPL224C YPL224C MMT2 hom Verified 0.843154707841901 0.199570962685261 no 1023 0.187514934688489 623 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt1p cellular iron ion homeostasis molecular_function mitochondrion|integral to membrane
YOR320C YOR320C GNT1 hom Verified 0.842605960392067 0.199724428241341 no 1024 0.194810544886162 649 NA FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|GOLGI APPARATUS N-acetylglucosaminyltransferase capable of modification of N-linked glycans in the Golgi apparatus protein N-linked glycosylation acetylglucosaminyltransferase activity Golgi medial cisterna
YMR058W YMR058W FET3 hom Verified 0.842194417125366 0.199839569140006 no 1025 0.214407888156651 723 NA FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS PLASMA MEMBRANE Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress iron assimilation by reduction and transport|high-affinity iron ion transport|response to copper ion ferroxidase activity|iron ion transmembrane transporter activity integral to membrane|high affinity iron permease complex|plasma membrane
YPL207W YPL207W TYW1 hom Verified 0.841744434558191 0.199965510203783 no 1026 0.196850042071139 707 NA FT RNA PROCESSING|OXIDATION-REDUCTION PROCESS ENDOPLASMIC RETICULUM Iron-sulfer protein required for synthesis of Wybutosine modified tRNA; Wybutosine is a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions; induction by Yap5p in response to iron provides protection from high iron toxicity; overexpression results in increased cellular iron wybutosine biosynthetic process molecular_function endoplasmic reticulum
YGL057C YGL057C GEP7 hom Verified 0.840603015653641 0.200285184372272 no 1027 0.213489830079686 714 NA FT MITOCHONDRION Protein of unknown function; null mutant exhibits a respiratory growth defect and synthetic interactions with prohibitin (phb1) and gem1; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YDR001C YDR001C NTH1 hom Verified 0.840347415325061 0.200356811736298 no 1028 0.191377633520927 644 NA FT CARBOHYDRATE METABOLISM Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p; NTH1 has a paralog, NTH2, that arose from the whole genome duplication trehalose catabolic process|response to stress alpha,alpha-trehalase activity cytosol|cytoplasm
YCR102W-A_d YCR102W-A YCR102W-A hom Dubious 0.840089822389771 0.200429013059382 no 1029 0.168630230003239 536 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YKR029C YKR029C SET3 hom Verified 0.839999687780589 0.200454280789241 no 1030 0.205452769987256 708 NA FT CELL CYCLE|CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Defining member of the SET3 histone deacetylase complex which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains; SET3 has a paralog, SET4, that arose from the whole genome duplication negative regulation of meiosis|regulation of transcription, DNA-dependent|histone deacetylation methylated histone residue binding Rpd3L-Expanded complex|Set3 complex
YOR032C YOR032C HMS1 hom Verified 0.83817972215747 0.200964886940042 no 1031 0.21430678455487 730 NA FT NUCLEUS Basic helix-loop-helix (bHLH) protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant pseudohyphal growth sequence-specific DNA binding transcription factor activity cellular_component
YJL077C YJL077C ICS3 hom Verified 0.837886505375637 0.201047224215019 no 1032 0.204932419396499 690 NA Protein of unknown function; may play a role in vacuolar sorting, null mutants are hypersensitive to sortin2 biological_process molecular_function cellular_component
YKR003W YKR003W OSH6 hom Verified 0.837670327693829 0.201107941340968 no 1033 0.178676461483781 661 NA FT VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Member of an oxysterol-binding protein family; overlapping, redundant functions in sterol metabolism and which collectively perform a function essential for viability; GFP-fusion protein localizes to the cell periphery; overexpression extends lifespan by promoting vacuolar fusion sterol homeostasis|maintenance of cell polarity|endocytosis|sterol transport|exocytosis|sterol metabolic process phosphatidic acid binding|lipid binding|phosphatidylinositol-3,4-bisphosphate binding|oxysterol binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-5-phosphate binding|phosphatidylinositol-4-phosphate binding cortical endoplasmic reticulum|extrinsic to membrane|cytoplasm
YJL164C YJL164C TPK1 hom Verified 0.837198874687683 0.201240394959677 no 1034 0.197542239109532 660 NA FT CELL CYCLE|SIGNALING|CELL DIVISION|PROTEIN PHOSPHORYLATION NUCLEUS cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; regulates Whi3p; partially redundant with Tpk2p and Tpk3p; TPK1 has a paralog, TPK3, that arose from the whole genome duplication protein phosphorylation|Ras protein signal transduction cAMP-dependent protein kinase activity|protein kinase activity cAMP-dependent protein kinase complex|nucleus|cytoplasm
YDL183C YDL183C YDL183C hom Verified 0.834378819397614 0.202033774435121 no 1035 0.228933263869192 751 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene potassium ion transport|proton transport molecular_function integral to mitochondrial inner membrane
YOR129C YOR129C AFI1 hom Verified 0.834192080145775 0.202086376671162 no 1036 0.187543180352512 645 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION NUCLEUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Arf3p polarization-specific docking factor, required for the polarized distribution of the ADP-ribosylation factor, Arf3p; participates in polarity development and maintenance of a normal haploid budding pattern; interacts with Cnm7p asymmetric protein localization|actin cortical patch localization|cellular bud site selection molecular_function nucleus|plasma membrane|cellular bud neck|cytoplasm
YPL006W YPL006W NCR1 hom Verified 0.834124118629013 0.202105522659633 no 1037 0.194575498847869 671 NA FT LIPID METABOLISM Vacuolar membrane protein that transits through the biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism; glycoprotein and functional orthologue of human Niemann Pick C1 (NPC1) protein sphingolipid metabolic process sphingolipid transporter activity fungal-type vacuole membrane|integral to membrane
YPR002W YPR002W PDH1 hom Verified 0.833927567344524 0.202160900820062 no 1038 0.210674407078308 747 NA FT KETONE METABOLISM MITOCHONDRION Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate propionate metabolic process|propionate catabolic process, 2-methylcitrate cycle 2-methylcitrate dehydratase activity mitochondrial outer membrane|mitochondrion|cytoplasm
YKR101W YKR101W SIR1 hom Verified 0.832881053814815 0.202455907957498 no 1039 0.181167968809594 620 NA FT CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Protein involved in repression of transcription at the silent mating-type loci HML and HMR; recruitment to silent chromatin requires interactions with Orc1p and with Sir4p, through a common Sir1p domain; binds to centromeric chromatin establishment of chromatin silencing|chromatin silencing at silent mating-type cassette chromatin binding|sequence-specific DNA binding chromatin silencing complex
YDL125C YDL125C HNT1 hom Verified 0.831522582747417 0.202839238112424 no 1040 0.19797774939934 676 NA FT NUCLEOTIDE METABOLISM NUCLEUS Adenosine 5'-monophosphoramidase; interacts physically and genetically with Kin28p, a CDK and TFIIK subunit, and genetically with CAK1; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins and similar to Hint; protein abundance increases in response to DNA replication stress nucleotide metabolic process hydrolase activity|nucleotide binding nucleus|cytoplasm
YAL067W-A_p YAL067W-A YAL067W-A hom Uncharacterized 0.831490964314916 0.202848165287171 no 1041 0.187108938526597 636 NA Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YER039C-A_p YER039C-A YER039C-A hom Uncharacterized 0.830947389962652 0.203001675224413 no 1042 0.198693643271788 680 NA Putative protein of unknown function; YER039C-A is not an essential gene biological_process molecular_function integral to membrane
YJL073W YJL073W JEM1 hom Verified 0.830213421715088 0.203209064030712 no 1043 0.210396817337322 767 NA FT PROTEOLYSIS ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM DnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane; exhibits genetic interactions with KAR2 karyogamy involved in conjugation with cellular fusion|ER-associated protein catabolic process|protein folding in endoplasmic reticulum unfolded protein binding|chaperone binding endoplasmic reticulum|nuclear outer membrane-endoplasmic reticulum membrane network
YGR187C YGR187C HGH1 hom Verified 0.829445112467985 0.203426291591321 no 1044 0.203338266878074 708 NA Nonessential protein of unknown function; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16); relative distribution to the nucleus increases upon DNA replication stress biological_process molecular_function cytoplasm
YJL080C YJL080C SCP160 hom Verified 0.829355112426424 0.203451746773024 no 1045 0.190119017645086 704 NA FT CELL CYCLE|SIGNALING|RNA LOCALIZATION|CHROMOSOME SEGREGATION|GENE SILENCING ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins meiotic telomere clustering|pheromone-dependent signal transduction involved in conjugation with cellular fusion|chromosome segregation|intracellular mRNA localization|chromatin silencing at silent mating-type cassette|chromatin silencing at telomere G-protein alpha-subunit binding|RNA binding endoplasmic reticulum membrane|polysome|nuclear outer membrane-endoplasmic reticulum membrane network
YIL097W YIL097W FYV10 hom Verified 0.829300573980947 0.203467173090927 no 1046 0.210349759810613 728 NA FT KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS NUCLEUS Subunit of GID complex; involved in proteasome-dependent catabolite inactivation of gluconeogenic enzymes FBPase, PEPCK, and c-MDH; forms dimer with Rmd5p that is then recruited to GID Complex by Gid8p; contains a degenerate RING finger motif needed for GID complex ubiquitin ligase activity in vivo, as well as CTLH and CRA domains; plays role in anti-apoptosis; required for survival upon exposure to K1 killer toxin negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis ubiquitin-protein ligase activity nucleus|GID complex|cytoplasm
YGR061C YGR061C ADE6 hom Verified 0.828800329215167 0.203608700959409 no 1047 0.203686793431755 681 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM Formylglycinamidine-ribonucleotide (FGAM)-synthetase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway 'de novo' IMP biosynthetic process|purine nucleotide biosynthetic process phosphoribosylformylglycinamidine synthase activity cytoplasm
YLR386W YLR386W VAC14 hom Verified 0.827011112786396 0.204115381413643 no 1048 0.24265634566866 850 NA FT PROTEIN LOCALIZATION|LIPID METABOLISM Protein involved in regulated synthesis of PtdIns(3,5)P(2), in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; interacts with Fig4p; activator of Fab1p phosphatidylinositol biosynthetic process|positive regulation of kinase activity protein binding, bridging fungal-type vacuole membrane|PAS complex|extrinsic to vacuolar membrane
YNL130C-A_p YNL130C-A DGR1 hom Uncharacterized 0.826984165393577 0.204123018265598 no 1049 0.186022538511866 658 NA FT MITOCHONDRION Protein of unknown function; dgr1 null mutant is resistant to 2-deoxy-D-glucose biological_process molecular_function cellular_component
YBR113W_d YBR113W YBR113W hom Dubious 0.826619111994832 0.204226490636678 no 1050 0.170470006046537 581 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CYC8 Unknown Unknown Unknown
YIL032C_d YIL032C YIL032C hom Dubious 0.826275263228811 0.20432398123202 no 1051 0.219316059846397 703 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YIL018W YIL018W RPL2B hom Verified 0.825867969054237 0.204439496188985 no 1052 0.186633414708311 610 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L2B; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2B has a paralog, RPL2A, that arose from the whole genome duplication; expression is upregulated at low temperatures cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YDR149C_d YDR149C YDR149C hom Dubious 0.823397407700376 0.205141018372923 no 1053 0.202780864611983 718 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene NUM1; null mutation blocks anaerobic growth Unknown Unknown Unknown
YOR112W YOR112W CEX1 hom Verified 0.821911494646771 0.205563635223194 no 1054 0.207832471150573 702 NA FT RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS Cytoplasmic component of the nuclear aminoacylation-dependent tRNA export pathway; interacts with nuclear pore component Nup116p; copurifies with tRNA export receptors Los1p and Msn5p, as well as eIF-1a and the RAN GTPase Gsp1p tRNA export from nucleus tRNA binding nuclear pore|cytoplasm
YGR269W_d YGR269W YGR269W hom Dubious 0.819958578403165 0.206119860447448 no 1055 0.218094113663586 752 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF HUA1/YGR268C Unknown Unknown Unknown
YNL257C YNL257C SIP3 hom Verified 0.819565538957713 0.206231912836933 no 1056 0.239004367430437 819 NA FT TRANSCRIPTION FROM RNA POL II Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog, YSP1, that arose from the whole genome duplication positive regulation of transcription from RNA polymerase II promoter transcription cofactor activity integral to membrane
YML024W YML024W RPS17A hom Verified 0.819202611407274 0.206335412624731 no 1057 0.193306637492798 642 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17A has a paralog, RPS17B, that arose from the whole genome duplication cytoplasmic translation|ribosomal small subunit assembly structural constituent of ribosome cytosolic small ribosomal subunit
YCL024W YCL024W KCC4 hom Verified 0.819181465698526 0.206341443913159 no 1058 0.205090368408472 691 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION SITE OF POLARIZED GROWTH|CYTOSKELETON Protein kinase of the bud neck involved in the septin checkpoint; associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p; KCC4 has a paralog, GIN4, that arose from the whole genome duplication budding cell bud growth|protein phosphorylation|septin checkpoint|septin ring assembly phosphatidic acid binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|protein kinase activity incipient cellular bud site|cellular bud neck septin collar|plasma membrane|cellular bud neck|septin ring
YIR009W YIR009W MSL1 hom Verified 0.819117918584104 0.206359569778597 no 1059 0.23088206829705 797 NA FT RNA PROCESSING NUCLEUS U2B component of U2 snRNP, involved in splicing, binds the U2 snRNA stem-loop IV in vitro but requires association of Lea1p for in vivo binding; does not contain the conserved C-terminal RNA binding domain found in other family members mRNA splicing, via spliceosome U2 snRNA binding U2 snRNP|U2-type prespliceosome
YMR037C YMR037C MSN2 hom Verified 0.819117061472263 0.206359814263399 no 1060 0.202076624067267 670 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|RESPONSE TO OXIDATIVE STRESS NUCLEUS Transcriptional activator; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression; MSN2 has a paralog, MSN4, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription from RNA polymerase II promoter in response to a hypotonic environment|positive regulation of transcription from RNA polymerase II promoter in response to alkalinity|positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation|positive regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation|positive regulation of transcription from RNA polymerase II promoter in response to acidity|chromatin remodeling|positive regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide|regulation of replicative cell aging by regulation of transcription from RNA polymerase II promoter in response to caloric restriction|positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance|positive regulation of transcription from RNA polymerase II promoter in response to increased salt|positive regulation of transcription from RNA polymerase II promoter in response to freezing|positive regulation of transcription from RNA polymerase II promoter in response to ethanol|age-dependent response to oxidative stress involved in chronological cell aging|replicative cell aging|positive regulation of transcription from RNA polymerase II promoter in response to hydrostatic pressure|cellular response to methylmercury|positive regulation of transcription from RNA polymerase II promoter in response to nitrosative stress|positive regulation of transcription from RNA polymerase II promoter in response to cold|positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding cytosol|nucleus
YEL049W YEL049W PAU2 hom Verified 0.818589426860933 0.206510350701029 no 1061 0.174834478171305 571 NA Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme biological_process molecular_function cellular_component
YBR187W_p YBR187W GDT1 hom Uncharacterized 0.816480335650035 0.207112732939986 no 1062 0.21100931306866 739 NA Putative protein of unknown function; expression is reduced in a gcr1 null mutant; GFP-fusion protein localizes to the vacuole; expression pattern and physical interactions suggest a possible role in ribosome biogenesis biological_process molecular_function integral to membrane|fungal-type vacuole
YNR074C YNR074C AIF1 hom Verified 0.816077506352007 0.207227904025185 no 1063 0.21041584253505 723 NA FT OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS NUCLEUS|MITOCHONDRION|PLASMA MEMBRANE Mitochondrial cell death effector that translocates to the nucleus in response to apoptotic stimuli, homolog of mammalian Apoptosis-Inducing Factor, putative reductase response to singlet oxygen|positive regulation of apoptotic process oxidoreductase activity, acting on a sulfur group of donors, NAD or NADP as acceptor mitochondrion|nucleus|plasma membrane
YLR102C YLR102C APC9 hom Verified 0.816037679601778 0.207239292766598 no 1064 0.19391090990469 687 NA FT CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION NUCLEUS UBIQUITIN LIGASE COMPLEX Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition chromatin assembly|protein ubiquitination ubiquitin-protein ligase activity anaphase-promoting complex
YBR010W YBR010W HHT1 hom Verified 0.815437779772622 0.207410883147448 no 1065 0.219750057093549 768 NA FT CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT2); regulated by acetylation, methylation, and phosphorylation chromatin assembly or disassembly|global genome nucleotide-excision repair|rRNA transcription|sexual sporulation resulting in formation of a cellular spore|mitotic cell cycle spindle assembly checkpoint DNA binding replication fork protection complex|nucleus|nuclear nucleosome
YLR345W_p YLR345W YLR345W hom Uncharacterized 0.815076902224187 0.207514146020107 no 1066 0.207478608070088 700 NA FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Similar to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase enzymes responsible for the metabolism of fructoso-2,6-bisphosphate; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene regulation of glycolysis|fructose 2,6-bisphosphate metabolic process 6-phosphofructo-2-kinase activity cytoplasm
YKL114C YKL114C APN1 hom Verified 0.814290435592381 0.207739293806128 no 1067 0.265043017204592 922 NA FF|FT RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine base-excision repair 3'-tyrosyl-DNA phosphodiesterase activity|DNA-(apurinic or apyrimidinic site) lyase activity|double-stranded DNA specific 3'-5' exodeoxyribonuclease activity|phosphoric diester hydrolase activity mitochondrion|nucleus
YPR118W YPR118W MRI1 hom Verified 0.814114880721763 0.207789570927455 no 1068 0.219665793036815 709 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS 5'-methylthioribose-1-phosphate isomerase; catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway L-methionine salvage from methylthioadenosine S-methyl-5-thioribose-1-phosphate isomerase activity nucleus|cytoplasm
YGR176W_d YGR176W YGR176W hom Dubious 0.812865907253295 0.208147471566008 no 1069 0.187148427663469 641 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR207C YDR207C UME6 hom Verified 0.81213064006437 0.208358336687046 no 1070 0.288081683907291 985 NA FF|FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS NUCLEUS|CHROMOSOME Key transcriptional regulator of early meiotic genes, binds URS1 upstream regulatory sequence, couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms complex with Ime1p, and also with Sin3p-Rpd3p spore germination|positive regulation of transcription from RNA polymerase II promoter during meiosis|negative regulation of transcription from RNA polymerase II promoter during meiosis|lipid particle organization|nitrogen catabolite repression of transcription from RNA polymerase II promoter|pseudohyphal growth|negative regulation of transcription from RNA polymerase II promoter during mitosis|Unknown RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|repressing transcription factor binding|transcription factor binding transcription factor activity Rpd3L-Expanded complex|Rpd3L complex
YLR322W_d YLR322W VPS65 hom Dubious 0.810756457143878 0.20875277222201 no 1071 0.222944753395245 780 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 75% of ORF overlaps the verified gene SFH1; deletion causes a vacuolar protein sorting defect and blocks anaerobic growth Unknown Unknown Unknown
YPR083W YPR083W MDM36 hom Verified 0.810754332146964 0.208753382506327 no 1072 0.215926220208916 703 NA FT MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial protein required for normal mitochondrial morphology and inheritance; proposed involvement in the formation of Dnm1p and Num1p-containing cortical anchor complexes that promote mitochondrial fission mitochondrial fission|mitochondrion organization molecular_function mitochondrion|cytoplasm
YGL025C YGL025C PGD1 hom Verified 0.810534118704814 0.208816631973511 no 1073 0.279045025696594 959 NA FF|FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II repressing transcription factor binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription factor recruiting transcription factor activity core mediator complex
YOR251C YOR251C TUM1 hom Verified 0.808984060667743 0.209262157343781 no 1074 0.173872319990929 611 NA FT RNA PROCESSING MITOCHONDRION Rhodanese domain sulfur transferase, accepts persulfite from Nfs1p and transfers it to Uba4p in the pathway for 2-thiolation of the wobble uridine base of tRNAs; also stimulates sulfur transfer by Nfs1p; may be mitochondrially localized tRNA wobble position uridine thiolation|tRNA wobble uridine modification thiosulfate sulfurtransferase activity cytoplasm
YBR191W YBR191W RPL21A hom Verified 0.807918045037561 0.209568881296122 no 1075 0.224394335358893 751 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YGR295C YGR295C COS6 hom Verified 0.807648132919391 0.209646584860047 no 1076 0.185295701191432 576 NA Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins biological_process molecular_function integral to membrane|fungal-type vacuole
YOR317W YOR317W FAA1 hom Verified 0.806837787539594 0.209879972651349 no 1077 0.211503032655319 746 NA FT KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM MITOCHONDRION Long chain fatty acyl-CoA synthetase; activates imported fatty acids with a preference for C12:0-C16:0 chain lengths; functions in long chain fatty acid import; accounts for most acyl-CoA synthetase activity; localized to lipid particles; involved in sphingolipid-to-glycerolipid metabolism; forms ER foci upon DNA replication stress; FAA1 has a paralog, FAA4, that arose from the whole genome duplication long-chain fatty acid transport|long-chain fatty-acyl-CoA metabolic process long-chain fatty acid-CoA ligase activity mitochondrial outer membrane|mitochondrion|lipid particle|plasma membrane
YDL089W YDL089W NUR1 hom Verified 0.805893190835468 0.210152218869601 no 1078 0.221628117626716 774 NA FT ENDOMEMBRANE SYSTEM|NUCLEUS Protein of unknown function; interacts with Csm1p, Lrs4p; required for rDNA repeat stability; null mutant causes increase in unequal sister-chromatid exchange; GFP-fusion protein localizes to the nuclear periphery, possible Cdc28p substrate maintenance of rDNA molecular_function nuclear periphery
YPR067W YPR067W ISA2 hom Verified 0.805602549325789 0.21023602760413 no 1079 0.24386438974011 826 NA FT KETONE METABOLISM|COFACTOR METABOLISM MITOCHONDRION Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa1p and possibly Iba57p; localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations iron-sulfur cluster assembly|biotin biosynthetic process iron ion binding mitochondrion|mitochondrial intermembrane space
YGR079W_p YGR079W YGR079W hom Uncharacterized 0.803931256751193 0.210718338609085 no 1080 0.208512336707512 725 NA Putative protein of unknown function; YGR079W is not an essential gene biological_process molecular_function cellular_component
YPR007C YPR007C REC8 hom Verified 0.803684606490259 0.210789573251867 no 1081 0.214844402344574 720 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p synaptonemal complex assembly|protein localization to chromosome, centromeric region|reciprocal meiotic recombination|meiotic sister chromatid cohesion molecular_function condensed nuclear chromosome|condensed nuclear chromosome, centromeric region
YLR357W YLR357W RSC2 hom Verified 0.802536088583667 0.211121460715142 no 1082 0.218038239816248 725 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS RSC COMPLEX Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenance ATP-dependent chromatin remodeling|chromosome segregation|nucleosome disassembly|plasmid maintenance|sister chromatid cohesion|double-strand break repair via nonhomologous end joining|transcription elongation from RNA polymerase II promoter|double-strand break repair via homologous recombination DNA translocase activity RSC complex
YMR157C YMR157C AIM36 hom Verified 0.802488964860292 0.2111350846048 no 1083 0.211637680032795 739 NA FT MITOCHONDRION Protein of unknown function; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YJL124C YJL124C LSM1 hom Verified 0.802329318817414 0.211181243532118 no 1084 0.241273017065485 838 NA FF|FT RNA PROCESSING NUCLEUS Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; forms cytoplasmic foci upon DNA replication stress deadenylation-dependent decapping of nuclear-transcribed mRNA|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay RNA binding|RNA cap binding mRNA cap binding complex|cytoplasmic mRNA processing body|cytoplasm
YOR106W YOR106W VAM3 hom Verified 0.802113103418961 0.211243767949351 no 1085 0.246534703148268 863 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|RESPONSE TO NUTRIENT LEVELS Syntaxin-like vacuolar t-SNARE that functions with Vam7p in vacuolar protein trafficking; mediates docking/fusion of late transport intermediates with the vacuole; has an acidic di-leucine sorting signal and C-terminal transmembrane region autophagic vacuole fusion|vesicle fusion with vacuole|piecemeal microautophagy of nucleus|vacuole fusion, non-autophagic|vesicle docking|vesicle fusion protein homodimerization activity|SNAP receptor activity SNARE complex|fungal-type vacuole membrane
YOR376W-A_p YOR376W-A YOR376W-A hom Uncharacterized 0.801686603581735 0.211367133482422 no 1086 0.192797508470182 632 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YML084W_d YML084W YML084W hom Dubious 0.800637305532283 0.211670823622918 no 1087 0.183031666999241 641 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGL200C YGL200C EMP24 hom Verified 0.800560845157726 0.211692962930538 no 1088 0.218465882816082 757 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles protein retention in ER lumen|vesicle organization|ER to Golgi vesicle-mediated transport molecular_function integral to membrane|endoplasmic reticulum|ER to Golgi transport vesicle
YKL140W YKL140W TGL1 hom Verified 0.798903129861145 0.212173291988084 no 1089 0.164858445130859 544 NA FT LIPID METABOLISM Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes cellular lipid metabolic process|sterol metabolic process lipase activity|sterol esterase activity integral to membrane|lipid particle
YIL149C YIL149C MLP2 hom Verified 0.797413604176033 0.212605430454044 no 1090 0.191650451580465 628 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CYTOSKELETON ORGANIZATION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION|CYTOSKELETON Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved in the Tel1p pathway that controls telomere length poly(A)+ mRNA export from nucleus|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|regulation of transcription, DNA-dependent|telomere tethering at nuclear periphery|spindle pole body organization|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery ribonucleoprotein complex binding nucleoplasm|nuclear envelope|mitochondrion|ribonucleoprotein complex|integral to membrane|spindle pole body
YPL026C YPL026C SKS1 hom Verified 0.797317249540686 0.212633402374268 no 1091 0.151751282088048 525 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN PHOSPHORYLATION NUCLEUS Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway glucose transport|protein phosphorylation|response to glucose stimulus|positive regulation of transcription from RNA polymerase II promoter protein serine/threonine kinase activity|protein kinase activity nucleus|cytoplasm
YBR068C YBR068C BAP2 hom Verified 0.797169826625604 0.212676203665304 no 1092 0.200042753821136 705 NA FT PLASMA MEMBRANE High-affinity leucine permease; functions as a branched-chain amino acid permease involved in uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains; BAP2 has a paralog, BAP3, that arose from the whole genome duplication amino acid transport|transmembrane transport amino acid transmembrane transporter activity integral to membrane|plasma membrane
YDL188C YDL188C PPH22 hom Verified 0.796611298360153 0.212838406789774 no 1093 0.211890266050113 687 NA FT CELL CYCLE|TRANSLATION|CELL DIVISION|CYTOSKELETON ORGANIZATION NUCLEUS|CHROMOSOME Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; PPH22 has a paralog, PPH21, that arose from the whole genome duplication actin filament organization|budding cell bud growth|G1/S transition of mitotic cell cycle|protein dephosphorylation|mitotic cell cycle spindle assembly checkpoint|regulation of translation protein serine/threonine phosphatase activity condensed nuclear chromosome, centromeric region
YOR369C YOR369C RPS12 hom Verified 0.796591932819905 0.212844032063507 no 1094 0.206654440677598 714 NA FT TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S12, no bacterial homolog cytoplasmic translation structural constituent of ribosome cytosolic small ribosomal subunit
YMR161W YMR161W HLJ1 hom Verified 0.796029021452523 0.213007583651024 no 1095 0.224030394865232 761 NA FT PROTEOLYSIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Co-chaperone for Hsp40p, anchored in the ER membrane; with its homolog Ydj1p promotes ER-associated protein degradation (ERAD) of integral membrane substrates; similar to E. coli DnaJ ER-associated protein catabolic process ATPase activator activity endoplasmic reticulum|endoplasmic reticulum membrane
YCL046W_d YCL046W YCL046W hom Dubious 0.795966217536813 0.213025835616749 no 1096 0.23386895377784 815 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YCL045C Unknown Unknown Unknown
YNL226W_d YNL226W YNL226W hom Dubious 0.795668747416375 0.213112298265746 no 1097 0.213272347084636 722 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene JJJ1/YNL227C Unknown Unknown Unknown
YBL029W_p YBL029W YBL029W hom Uncharacterized 0.795080057153771 0.213283467273351 no 1098 0.226475606641492 759 NA FT NUCLEUS Non-essential protein of unknown function biological_process molecular_function nucleus|cytoplasm
YNL198C_d YNL198C YNL198C hom Dubious 0.795026616448224 0.213299009790248 no 1099 0.202950578940452 683 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGL081W_p YGL081W YGL081W hom Uncharacterized 0.794487736646825 0.21345577269774 no 1100 0.18034311532441 562 NA Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis biological_process molecular_function cellular_component
YER117W YER117W RPL23B hom Verified 0.793712516287672 0.213681406033916 no 1101 0.209868878242039 734 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L23B; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23B has a paralog, RPL23A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YMR111C YMR111C YMR111C hom Verified 0.792660801915876 0.213987736893514 no 1102 0.186499404101576 572 NA FT NUCLEUS Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress biological_process molecular_function nucleus
YAL067C YAL067C SEO1 hom Verified 0.792414257438632 0.214059584407377 no 1103 0.200330078676429 649 NA Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide transport transporter activity integral to membrane|membrane
YDR120C YDR120C TRM1 hom Verified 0.791605218059782 0.214295451702039 no 1104 0.22520856744261 783 NA FT RNA PROCESSING ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments tRNA methylation tRNA (guanine-N2-)-methyltransferase activity mitochondrion|nuclear envelope|nuclear inner membrane
YDR423C YDR423C CAD1 hom Verified 0.791521155592905 0.214319967935861 no 1105 0.22248862146498 740 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS AP-1-like basic leucine zipper (bZIP) transcriptional activator; involved in stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins; binds consensus sequence TTACTAA; CAD1 has a paralog, YAP1, that arose from the whole genome duplication cellular response to cadmium ion|positive regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus|cytoplasm
YLR111W_d YLR111W YLR111W hom Dubious 0.790388468880972 0.214650467189198 no 1106 0.23672501659763 877 NA FF Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YKL096W YKL096W CWP1 hom Verified 0.790355552707847 0.214660076011155 no 1107 0.195028372239433 667 NA FT MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS Cell wall mannoprotein that localizes specifically to birth scars of daughter cells, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; required for propionic acid resistance fungal-type cell wall organization|ascospore-type prospore membrane assembly structural constituent of cell wall fungal-type cell wall|cellular birth scar|prospore membrane
YBR291C YBR291C CTP1 hom Verified 0.789244294061959 0.214984619016397 no 1108 0.223333965831272 789 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family mitochondrial citrate transport|transmembrane transport tricarboxylate secondary active transmembrane transporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YMR194C-B YMR194C-B CMC4 hom Verified 0.788957212428037 0.215068507478147 no 1109 0.196924203232823 663 NA FT MITOCHONDRION Protein that localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; contains twin cysteine-x(9)-cysteine motifs biological_process molecular_function mitochondrial intermembrane space
YIL038C YIL038C NOT3 hom Verified 0.787521277570362 0.215488388867641 no 1110 0.217723668634654 724 NA FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation regulation of transcription from RNA polymerase II promoter|nuclear-transcribed mRNA poly(A) tail shortening|positive regulation of transcription elongation from RNA polymerase II promoter|protein ubiquitination ubiquitin-protein ligase activity CCR4-NOT core complex|cytoplasm
YDL061C YDL061C RPS29B hom Verified 0.786452582223658 0.215801194218898 no 1111 0.200883574949989 690 NA FT TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29B has a paralog, RPS29A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic small ribosomal subunit
YGR086C YGR086C PIL1 hom Verified 0.786004273994442 0.215932491608574 no 1112 0.200733487279673 681 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION MITOCHONDRION Primary protein component of eisosomes; eisosomes are large immobile cell cortex structures associated with endocytosis; null mutant shows activation of Pkc1p/Ypk1p stress resistance pathways; detected in phosphorylated state in mitochondria; member of the BAR domain family; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress eisosome assembly|endocytosis|negative regulation of protein kinase activity|response to heat|protein localization lipid binding mitochondrial outer membrane|eisosome|mitochondrion|plasma membrane|cytoplasm
YDL123W YDL123W SNA4 hom Verified 0.78597188891155 0.21594197811817 no 1113 0.23305221777519 758 NA Protein of unknown function, localized to the vacuolar outer membrane; predicted to be palmitoylated biological_process molecular_function fungal-type vacuole lumen|fungal-type vacuole membrane
YGL035C YGL035C MIG1 hom Verified 0.785849671079846 0.215977781363748 no 1114 0.236107708787531 824 NA FT TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS ENDOMEMBRANE SYSTEM|NUCLEUS Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion negative regulation of transcription from RNA polymerase II promoter by glucose|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding nucleus|nuclear envelope lumen|cytoplasm
YGL217C_d YGL217C YGL217C hom Dubious 0.785492982482923 0.216082291584358 no 1115 0.193772876107306 644 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF KIP3/YGL216W Unknown Unknown Unknown
YGR109C YGR109C CLB6 hom Verified 0.784433391897182 0.216392925692636 no 1116 0.207044306575449 703 NA FT CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION NUCLEUS B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 regulation of cyclin-dependent protein kinase activity|G1/S transition of mitotic cell cycle|regulation of S phase of mitotic cell cycle|premeiotic DNA replication cyclin-dependent protein kinase regulator activity cellular_component
YOR374W YOR374W ALD4 hom Verified 0.78394956597258 0.216534852077586 no 1117 0.20376019670137 680 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM MITOCHONDRION Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed NADPH regeneration|ethanol metabolic process|pyruvate metabolic process|acetate biosynthetic process aldehyde dehydrogenase [NAD(P)+] activity|aldehyde dehydrogenase (NAD) activity mitochondrial nucleoid|mitochondrion
YER091C YER091C MET6 hom Verified 0.783239203923494 0.216743328540461 no 1118 0.143039816247899 495 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Cobalamin-independent methionine synthase, involved in methionine biosynthesis and regeneration; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs methionine biosynthetic process 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity plasma membrane|cytoplasm
YPR093C YPR093C ASR1 hom Verified 0.782845897368669 0.216858805727052 no 1119 0.214698412038439 705 NA FT NUCLEUS Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain similar to the mammalian rA9 protein response to ethanol|protein ubiquitination ubiquitin-protein ligase activity nucleus|cytoplasm
YML002W_p YML002W YML002W hom Uncharacterized 0.782783686884786 0.216877074359295 no 1120 0.190671774281983 624 NA Putative protein of unknown function; expression induced by heat and by calcium shortage biological_process molecular_function cellular_component
YPR008W YPR008W HAA1 hom Verified 0.782479739820368 0.216966343764471 no 1121 0.205188817046954 698 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Transcriptional activator involved in adaptation to weak acid stress; activates transcription of TPO2, YRO2, and other genes encoding membrane stress proteins; HAA1 has a paralog, CUP2, that arose from the whole genome duplication; relocalizes from cytoplasm to nucleus upon DNA replication stress response to acid|positive regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding RNA polymerase II transcription factor activity nucleus
YER039C YER039C HVG1 hom Verified 0.782317492901649 0.217014004458488 no 1122 0.218673883522916 743 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Protein of unknown function, has homology to Vrg4p biological_process molecular_function integral to membrane
YNL004W YNL004W HRB1 hom Verified 0.78187078464713 0.217145258087367 no 1123 0.225390949196265 774 NA FT RNA LOCALIZATION NUCLEUS Poly(A+) RNA-binding protein; involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Npl3p; HRB1 has a paralog, GBP2, that arose from the whole genome duplication poly(A)+ mRNA export from nucleus RNA binding integral to membrane|nucleus|cytoplasm
YMR269W YMR269W TMA23 hom Verified 0.781834715281647 0.21715585813515 no 1124 0.217225116265745 759 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS NUCLEUS Nucleolar protein implicated in ribosome biogenesis; deletion extends chronological lifespan ribosomal small subunit biogenesis molecular_function ribosome|nucleolus
YOR054C YOR054C VHS3 hom Verified 0.780313549553547 0.217603169659929 no 1125 0.228077860181145 759 NA FT CELL CYCLE|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|COFACTOR METABOLISM Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis coenzyme A biosynthetic process|cellular monovalent inorganic cation homeostasis phosphopantothenoylcysteine decarboxylase activity|protein phosphatase inhibitor activity phosphopantothenoylcysteine decarboxylase complex
YNL139C YNL139C THO2 hom Verified 0.77919990057227 0.217930984338593 no 1126 0.258515274657952 840 NA FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION NUCLEUS Subunit of the THO complex, which is required for efficient transcription elongation and involved in transcriptional elongation-associated recombination; required for LacZ RNA expression from certain plasmids mRNA 3'-end processing|mRNA export from nucleus|transcription-coupled nucleotide-excision repair|DNA recombination|transcription elongation from RNA polymerase II promoter DNA binding|nucleic acid binding THO complex part of transcription export complex|nucleus|nucleoplasmic THO complex
YPR009W YPR009W SUT2 hom Verified 0.778748708453465 0.218063878656846 no 1127 0.232602174486654 745 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1p positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter RNA polymerase II repressing transcription factor binding|sequence-specific DNA binding nucleus
YLR308W YLR308W CDA2 hom Verified 0.778431887830095 0.21815722304909 no 1128 0.21456746371313 744 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM Chitin deacetylase, together with Cda1p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall ascospore wall assembly chitin deacetylase activity chitosan layer of spore wall
YLL062C YLL062C MHT1 hom Verified 0.778155089450185 0.21823879459174 no 1129 0.213736634002525 703 NA FT KETONE METABOLISM|AMINO ACID METABOLISM S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio sulfur amino acid metabolic process homocysteine S-methyltransferase activity cytoplasm
YPR188C YPR188C MLC2 hom Verified 0.778016075199537 0.218279768248014 no 1130 0.212825646846637 711 NA FT CELL CYCLE|CELL DIVISION SITE OF POLARIZED GROWTH|CYTOSKELETON Regulatory light chain for the type II myosin, Myo1p; binds to an IQ motif of Myo1p, localization to the bud neck depends on Myo1p; involved in the disassembly of the Myo1p ring actomyosin contractile ring contraction myosin II binding cellular bud neck contractile ring
YOR050C_d YOR050C YOR050C hom Dubious 0.777096240508309 0.218550995932962 no 1131 0.193215171333794 666 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable Unknown Unknown Unknown
YNL323W YNL323W LEM3 hom Verified 0.777089174809508 0.218553080115791 no 1132 0.311455021456973 1080 NA FF|FT MEMBRANE ORGANIZATION|SIGNALING ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Membrane protein of the plasma membrane and ER, interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane phospholipid translocation|cell surface receptor signaling pathway phospholipid-translocating ATPase activity integral to membrane|endoplasmic reticulum|plasma membrane|cytoplasm
YER063W YER063W THO1 hom Verified 0.776111179074361 0.218841671803209 no 1133 0.182499771704086 605 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA LOCALIZATION NUCLEUS Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation poly(A)+ mRNA export from nucleus|transcription, DNA-dependent|ribonucleoprotein complex assembly chromatin binding|double-stranded DNA binding|RNA binding nucleus
YIL099W YIL099W SGA1 hom Verified 0.775901729433251 0.218903505705293 no 1134 0.212628300611694 698 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation ascospore formation|glycogen catabolic process glucan 1,4-alpha-glucosidase activity fungal-type vacuole
YOR190W YOR190W SPR1 hom Verified 0.774503423452177 0.219316572242263 no 1135 0.220701272233569 767 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance ascospore formation glucan exo-1,3-beta-glucosidase activity fungal-type cell wall|ascospore wall
YLR123C_d YLR123C YLR123C hom Dubious 0.773619907281089 0.219577798081573 no 1136 0.194155258815039 666 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif Unknown Unknown Unknown
YLR187W YLR187W SKG3 hom Verified 0.773380549234271 0.219648598909819 no 1137 0.218727665696754 701 NA FT SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate; similar to Skg4p; relocalizes from bud neck to cytoplasm upon DNA replication stress; SKG3 has a paralog, CAF120, that arose from the whole genome duplication biological_process molecular_function cellular bud|cellular bud neck|cytoplasm
YGR053C_p YGR053C YGR053C hom Uncharacterized 0.773191599482965 0.21970449849187 no 1138 0.21810986293324 734 NA Putative protein of unknown function biological_process molecular_function cellular_component
YLR395C YLR395C COX8 hom Verified 0.773058547183085 0.219743866068923 no 1139 0.236566257368866 801 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain mitochondrial electron transport, cytochrome c to oxygen cytochrome-c oxidase activity mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YDR055W YDR055W PST1 hom Verified 0.772245665066027 0.219984469946266 no 1140 0.217569031899752 705 NA FT CELL WALL ORG/BIOGENESIS PLASMA MEMBRANE Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1 fungal-type cell wall organization molecular_function fungal-type cell wall|plasma membrane
YMR071C YMR071C TVP18 hom Verified 0.771985618329841 0.220061472728414 no 1141 0.252375245061281 876 NA FF|FT VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments vesicle-mediated transport molecular_function integral to membrane|integral to Golgi membrane|clathrin-coated vesicle
YMR313C YMR313C TGL3 hom Verified 0.771472520363751 0.220213452188105 no 1142 0.214366172622398 747 NA FT LIPID METABOLISM|CELL DIVISION Bifunctional enzyme with triacylglycerol lipase and lysophosphatidylethanolamine acyltransferase activity; responsible for all the triacylglycerol lipase activity of the lipid particle; required with Tgl4p for timely bud formation triglyceride catabolic process|cell budding|cellular lipid metabolic process triglyceride lipase activity|lysophosphatidylethanolamine acyltransferase activity lipid particle
YPR030W YPR030W CSR2 hom Verified 0.77112507614647 0.220316399227253 no 1143 0.232864256769049 808 NA FT VESICLE-MEDIATED TRANSPORT|TRANSCRIPTION FROM RNA POL II|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS NUCLEUS Nuclear ubiquitin protein ligase binding protein; may regulate utilization of nonfermentable carbon sources and endocytosis of plasma membrane proteins; overproduction suppresses chs5 spa2 lethality at high temp; ubiquitinated by Rsp5p, deubiquitinated by Ubp2p; CSR2 has a paralog, ECM21, that arose from the whole genome duplication fungal-type cell wall organization|regulation of transcription from RNA polymerase II promoter|ubiquitin-dependent endocytosis ubiquitin protein ligase binding nucleus
YNL079C YNL079C TPM1 hom Verified 0.770806856299111 0.220410711345838 no 1144 0.225049098475039 791 NA FF|FT VESICLE-MEDIATED TRANSPORT|CELL DIVISION|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|RNA LOCALIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently; TPM1 has a paralog, TPM2, that arose from the whole genome duplication vacuole inheritance|exocytosis|intracellular mRNA localization|filamentous growth|budding cell apical bud growth|mitochondrion inheritance|budding cell isotropic bud growth|actin polymerization or depolymerization|actin filament organization|pseudohyphal growth|vesicle-mediated transport|establishment of cell polarity|actin filament bundle assembly actin lateral binding cellular bud neck contractile ring|actin filament bundle
YBR099C_d YBR099C YBR099C hom Dubious 0.766963520738871 0.22155160244575 no 1145 0.207764520503154 694 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4 Unknown Unknown Unknown
YNR002C YNR002C ATO2 hom Verified 0.765842954349891 0.221884876129269 no 1146 0.193134206476385 637 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION|PLASMA MEMBRANE Putative transmembrane protein involved in export of ammonia; ammonia is a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Y. lipolytica Gpr1p; ATO2 has a paralog, ADY2, that arose from the whole genome duplication ammonium transport|nitrogen utilization ammonium transmembrane transporter activity mitochondrion|integral to membrane|plasma membrane
YER084W_p YER084W YER084W hom Uncharacterized 0.765045855360721 0.222122119800278 no 1147 0.231915018540032 791 NA Protein of unknown function; expressed at both mRNA and protein levels biological_process molecular_function cellular_component
YDR370C YDR370C DXO1 hom Verified 0.764325982312494 0.222336502783158 no 1148 0.21756722956082 735 NA Protein with decapping and 5′-3′ exoRNase activity; similar to Rai1p biological_process molecular_function cytoplasm
YKR060W YKR060W UTP30 hom Verified 0.764152893108322 0.222388067497081 no 1149 0.23445444712846 761 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION NUCLEUS Putative subunit of U3-containing 90S preribosome complex; complex is involved in production of 18S rRNA and assembly of small ribosomal subunit ribosomal small subunit biogenesis molecular_function nucleolus|nucleus|90S preribosome
YGL163C YGL163C RAD54 hom Verified 0.763277739992438 0.22264888730343 no 1150 0.291923396730829 974 NA FF|FT CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS DNA-dependent ATPase that stimulates strand exchange; modifies the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family; forms nuclear foci upon DNA replication stress positive regulation of endodeoxyribonuclease activity|DNA geometric change|heteroduplex formation|telomere maintenance via recombination|double-strand break repair via synthesis-dependent strand annealing|chromatin remodeling|double-strand break repair via single-strand annealing DNA-dependent ATPase activity|DNA translocase activity nucleus
YIL133C YIL133C RPL16A hom Verified 0.761579877041299 0.223155394344066 no 1151 0.223154330284839 781 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L16A; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16A has a paralog, RPL16B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress cytoplasmic translation structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YEL063C YEL063C CAN1 hom Verified 0.761005677242639 0.223326838146756 no 1152 0.238463687054937 833 NA FT MITOCHONDRION|PLASMA MEMBRANE Plasma membrane arginine permease; requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; CAN1 has a paralog, ALP1, that arose from the whole genome duplication basic amino acid transport|transmembrane transport basic amino acid transmembrane transporter activity|arginine transmembrane transporter activity mitochondrion|integral to membrane|membrane raft|plasma membrane
YMR118C_p YMR118C SHH3 hom Uncharacterized 0.758624387738695 0.224038639841107 no 1153 0.202733015918077 671 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Putative mitochondrial inner membrane protein of unknown function; although similar to Sdh3p, Shh3p is not a stoichiometric subunit of either succinate dehydrogenase or of the TIM22 translocase biological_process molecular_function integral to membrane
YOR155C YOR155C ISN1 hom Verified 0.758098891454478 0.224195891649094 no 1154 0.22157424858255 735 NA FT NUCLEOTIDE METABOLISM Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms nicotinamide riboside biosynthetic process|inosine salvage|nicotinic acid riboside biosynthetic process IMP 5'-nucleotidase activity cellular_component
YMR297W YMR297W PRC1 hom Verified 0.75770532452822 0.224313705376304 no 1155 0.186425663158116 649 NA FT PROTEOLYSIS ENDOPLASMIC RETICULUM Vacuolar carboxypeptidase Y (proteinase C; CPY), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family vacuolar protein catabolic process|phytochelatin biosynthetic process serine-type carboxypeptidase activity fungal-type vacuole lumen|endoplasmic reticulum|fungal-type vacuole|cytoplasm
YOR316C-A_p YOR316C-A YOR316C-A hom Uncharacterized 0.756722937180516 0.224607935003687 no 1156 0.199557050051977 661 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YDL085C-A_p YDL085C-A YDL085C-A hom Uncharacterized 0.754963700793725 0.225135381258118 no 1157 0.230346685270218 785 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus biological_process molecular_function nucleus|cytoplasm
YGR257C YGR257C MTM1 hom Verified 0.754463922280711 0.225285350470159 no 1158 0.258668773935547 922 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor manganese ion transport|transport transporter activity|metallochaperone activity mitochondrion|integral to membrane|mitochondrial inner membrane
YNR070W_p YNR070W PDR18 hom Uncharacterized 0.754250485560435 0.225349413950173 no 1159 0.204121243445876 719 NA FT NUCLEOTIDE METABOLISM MITOCHONDRION Putative transporter of the ATP-binding cassette (ABC) family, implicated in pleiotropic drug resistance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies transport ATPase activity, coupled to transmembrane movement of substances mitochondrion|integral to membrane|membrane
YNL338W_d YNL338W YNL338W hom Dubious 0.752180371606543 0.225971297952272 no 1160 0.210059645520533 735 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps TEL14L-XC, which is Telomeric X element Core sequence on the left arm of Chromosome XIV Unknown Unknown Unknown
YBR300C_d YBR300C YBR300C hom Dubious 0.752033945313954 0.226015322661828 no 1161 0.235714726106062 822 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR301W; YBR300C is not an essential gene Unknown Unknown Unknown
YMR031W-A_d YMR031W-A YMR031W-A hom Dubious 0.751869544917531 0.226064757264936 no 1162 0.224717727478435 747 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C Unknown Unknown Unknown
YMR209C_p YMR209C YMR209C hom Uncharacterized 0.751591469955497 0.226148387307173 no 1163 0.227631400157837 797 NA Putative S-adenosylmethionine-dependent methyltransferase; YMR209C is not an essential gene biological_process S-adenosylmethionine-dependent methyltransferase activity cellular_component
YKL220C YKL220C FRE2 hom Verified 0.747174043715286 0.227479254933407 no 1164 0.198079429562924 657 NA FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY PLASMA MEMBRANE Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels iron ion transport|copper ion import ferric-chelate reductase activity integral to membrane|plasma membrane
YGL060W YGL060W YBP2 hom Verified 0.746934123013274 0.227551663529612 no 1165 0.232815824187794 839 NA FT CELL CYCLE NUCLEUS|CHROMOSOME KINETOCHORE Central kinetochore associated protein; mediates mitotic progression; interacts with several central kinetochore proteins and centromeric histone Cse4p; role in resistance to oxidative stress; similar to Slk19p; YBP2 has a paralog, YBP1, that arose from the whole genome duplication G2/M transition of mitotic cell cycle molecular_function condensed nuclear chromosome kinetochore|centromere-specific nucleosome|cytoplasm
YNL035C YNL035C YNL035C hom Verified 0.746328166662452 0.227734600264474 no 1166 0.201594153593903 677 NA FT NUCLEUS Protein of unknown function; contains WD-40 domains; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YNL035C is not an essential gene; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus
YMR077C YMR077C VPS20 hom Verified 0.74590530245619 0.227862310954916 no 1167 0.264954726885492 918 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT Myristoylated subunit of ESCRTIII, the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranes intralumenal vesicle formation|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|late endosome to vacuole transport protein binding ESCRT III complex|cytoplasm
YPR160W YPR160W GPH1 hom Verified 0.745033535987311 0.228125723312101 no 1168 0.197169338337864 634 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway glycogen catabolic process glycogen phosphorylase activity cytoplasm
YOR069W YOR069W VPS5 hom Verified 0.744818962738549 0.22819058486699 no 1169 0.245285990878887 839 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Nexin-1 homolog required for localizing membrane proteins from a prevacuolar/late endosomal compartment back to the late Golgi apparatus; structural component of the retromer membrane coat complex; forms a retromer subcomplex with Vps17p; required for recruiting the retromer complex to the endosome membranes protein retention in Golgi apparatus|retrograde transport, endosome to Golgi protein transporter activity|phosphatidylinositol-3-phosphate binding cytosol|endosome|retromer complex, outer shell|retromer complex
YGR028W YGR028W MSP1 hom Verified 0.744019968396623 0.22843219735388 no 1170 0.210938174350541 692 NA FT PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial protein involved in sorting of proteins in the mitochondria; putative membrane-spanning ATPase protein targeting to mitochondrion ATPase activity mitochondrial outer membrane|mitochondrion
YKL197C YKL197C PEX1 hom Verified 0.743503407504989 0.228588479642121 no 1171 0.224059508006091 777 NA FT PROTEIN LOCALIZATION|SIGNALING|PEROXISOME ORGANIZATION AAA-peroxin that heterodimerizes with AAA-peroxin Pex6p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; induced by oleic acid and upregulated during anaerobiosis protein import into peroxisome matrix, receptor recycling ATPase activity|protein heterodimerization activity peroxisomal membrane|peroxisome
YML054C YML054C CYB2 hom Verified 0.74329460228287 0.228651669403946 no 1172 0.190122316657135 620 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions lactate metabolic process L-lactate dehydrogenase (cytochrome) activity mitochondrion|mitochondrial intermembrane space
YPR097W YPR097W YPR097W hom Verified 0.740507917237619 0.229495929480145 no 1173 0.248214507339741 858 NA FT MITOCHONDRION Protein that contains a Phox homology (PX) domain and binds phosphoinositides; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process phosphatidylinositol binding mitochondrion
YLR389C YLR389C STE23 hom Verified 0.738567304723551 0.230084891905586 no 1174 0.208780706910343 739 NA FT PROTEOLYSIS Metalloprotease involved, with homolog Axl1p, in N-terminal processing of pro-a-factor to the mature form; expressed in both haploids and diploids; member of the insulin-degrading enzyme family peptide pheromone maturation metallopeptidase activity|metalloendopeptidase activity extrinsic to membrane
YPR072W YPR072W NOT5 hom Verified 0.738484728214475 0.230109972047507 no 1175 0.231616111561043 777 NA FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation deadenylation-independent decapping of nuclear-transcribed mRNA|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|nuclear-transcribed mRNA poly(A) tail shortening|transcription elongation from RNA polymerase II promoter|protein ubiquitination ubiquitin-protein ligase activity CCR4-NOT core complex|cytoplasm
YDL117W YDL117W CYK3 hom Verified 0.73814351648263 0.230213621109808 no 1176 0.226598447322199 754 NA FT CELL CYCLE|CELL DIVISION SITE OF POLARIZED GROWTH|CYTOSKELETON SH3-domain protein located in the bud neck and cytokinetic actin ring; relocalizes from bud neck to nucleus upon DNA replication stress; activates the chitin synthase activity of Chs2p during cytokinesis; suppressor of growth and cytokinesis defects of chs2 phospho-mutants barrier septum assembly involved in cell cycle cytokinesis|cytokinesis molecular_function cellular bud neck contractile ring|cellular bud neck|cytoplasm
YLR144C YLR144C ACF2 hom Verified 0.737934699806747 0.230277065724869 no 1177 0.225976428076132 783 NA FT CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION Intracellular beta-1,3-endoglucanase; expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly; protein abundance increases in response to DNA replication stress actin cytoskeleton organization glucan endo-1,3-beta-D-glucosidase activity intracellular
YLR041W_d YLR041W YLR041W hom Dubious 0.737484216216935 0.230413969114309 no 1178 0.208955570597952 722 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YLR040C Unknown Unknown Unknown
YBR168W YBR168W PEX32 hom Verified 0.735551311362692 0.231001901201685 no 1179 0.24458589801173 854 NA FT PEROXISOME ORGANIZATION Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p peroxisome organization molecular_function integral to membrane|integral to peroxisomal membrane
YHR001W YHR001W OSH7 hom Verified 0.734872447135377 0.231208590016496 no 1180 0.205429650797055 678 NA FT VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT ENDOPLASMIC RETICULUM Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability maintenance of cell polarity|endocytosis|exocytosis|sterol transport|sterol metabolic process|late endosome to vacuole transport lipid binding|oxysterol binding integral to membrane|cortical endoplasmic reticulum|cytoplasm
YML003W_p YML003W YML003W hom Uncharacterized 0.734072806284968 0.231452183095644 no 1181 0.211457113994496 695 NA Putative protein of unknown function biological_process molecular_function cellular_component
YDL162C_d YDL162C YDL162C hom Dubious 0.733806384484404 0.231533374433909 no 1182 0.23047071420506 775 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps ENT1/YDL161W, a verified gene involved in endocytosis and actin cortical patch assembly Unknown Unknown Unknown
YJL118W YJL118W YJL118W hom Verified 0.732079364184351 0.232060064156443 no 1183 0.212123000487248 719 NA Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; YJL18W is a non-essential gene; deletion enhances the toxicity of heterologously expressed human alpha-synuclein biological_process molecular_function ribosome
YPL041C_p YPL041C YPL041C hom Uncharacterized 0.7319825643208 0.23208960495722 no 1184 0.224911156186135 701 NA Protein of unknown function involved in maintenance of proper telomere length biological_process molecular_function cellular_component
YLR325C YLR325C RPL38 hom Verified 0.730841619287817 0.232437949408173 no 1185 0.252364180703043 835 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L38; homologous to mammalian ribosomal protein L38, no bacterial homolog cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YKL039W YKL039W PTM1 hom Verified 0.729555369088983 0.232831005746411 no 1186 0.221523298995854 731 NA FT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Protein of unknown function; copurifies with late Golgi vesicles containing the v-SNARE Tlg2p; PTM1 has a paralog, YHL017W, that arose from the whole genome duplication biological_process molecular_function integral to membrane
YDR274C_d YDR274C YDR274C hom Dubious 0.72954035513059 0.232835595937952 no 1187 0.208055051073138 690 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YBR056W-A_p YBR056W-A YBR056W-A hom Uncharacterized 0.729424924358289 0.232870888067565 no 1188 0.265934437023355 880 NA Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the dubious ORF YBR056C-B biological_process molecular_function cellular_component
YLL048C YLL048C YBT1 hom Verified 0.729232216001544 0.232929813885255 no 1189 0.228666878917793 753 NA FT NUCLEOTIDE METABOLISM Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates the release of lumenal Ca2+ stores; similar to mammalian bile transporters bile acid and bile salt transport bile acid-exporting ATPase activity integral to membrane|fungal-type vacuole
YGL199C_d YGL199C YGL199C hom Dubious 0.728692229047849 0.233094973683527 no 1190 0.203002572749304 674 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YIP4/YGL198W Unknown Unknown Unknown
YBL071W-A YBL071W-A KTI11 hom Verified 0.728260208231784 0.233227157887574 no 1191 0.284990307748992 982 NA FT RNA PROCESSING NUCLEUS Zn-ribbon protein that co-purifies with Dph1 and Dph2 in a complex required for synthesis of diphthamide on translation factor eEF2 and with Elongator subunits Iki3p, Elp2p, and Elp3p involved in modification of wobble nucleosides in tRNAs peptidyl-diphthamide biosynthetic process from peptidyl-histidine|tRNA wobble uridine modification electron carrier activity|iron ion binding|zinc ion binding nucleus|cytoplasm
YIL006W YIL006W YIA6 hom Verified 0.727866693740058 0.233347596618235 no 1192 0.246172585678701 849 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Mitochondrial NAD+ transporter, involved in the transport of NAD+ into the mitochondria (see also YEA6); member of the mitochondrial carrier subfamily; disputed role as a pyruvate transporter; has putative mouse and human orthologs transport|mitochondrial pyruvate transport|NAD transmembrane transport pyruvate secondary active transmembrane transporter activity|transporter activity|NAD transporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YBR039W YBR039W ATP3 hom Verified 0.727358844775844 0.233503079459439 no 1193 0.258234080147485 917 NA FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS MITOCHONDRION Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis ATP synthesis coupled proton transport proton-transporting ATPase activity, rotational mechanism mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase, central stalk
YOL057W YOL057W YOL057W hom Verified 0.727100486906067 0.233582200250697 no 1194 0.219544089284731 712 NA FT PROTEOLYSIS NUCLEUS Dipeptidyl-peptidase III; cleaves dipeptides from the amino terminus of target proteins; highly active on synthetic substrate Arg-Arg-2-naphthylamide; mammalian ortholog may be a biomarker for some cancers proteolysis dipeptidyl-peptidase activity nucleus|cytoplasm
YIL163C_p YIL163C YIL163C hom Uncharacterized 0.72665849523116 0.233717592431852 no 1195 0.221208570441808 759 NA Protein of unknown function; mRNA identified as translated by ribosome profiling data biological_process molecular_function cellular_component
YCR048W YCR048W ARE1 hom Verified 0.724861108572065 0.234268621074551 no 1196 0.202508705477138 694 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the absence of oxygen; ARE1 has a paralog, ARE2, that arose from the whole genome duplication sterol metabolic process ergosterol O-acyltransferase activity|lanosterol O-acyltransferase activity integral to membrane|endoplasmic reticulum
YKL166C YKL166C TPK3 hom Verified 0.724203779981459 0.234470319140912 no 1197 0.206061932854904 717 NA FT SIGNALING|MITOCHONDRION ORGANIZATION|PROTEIN PHOSPHORYLATION NUCLEUS cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication protein phosphorylation|mitochondrion organization|Ras protein signal transduction cAMP-dependent protein kinase activity|protein kinase activity cAMP-dependent protein kinase complex|nucleus|cytoplasm
YNL097C-B_p YNL097C-B YNL097C-B hom Uncharacterized 0.723872001981817 0.23457216007235 no 1198 0.209711607891678 685 NA Putative protein of unknown function biological_process molecular_function cellular_component
YPL055C YPL055C LGE1 hom Verified 0.722237938581647 0.23507410090221 no 1199 0.262062641771711 899 NA FT CHROMATIN ORGANIZATION NUCLEUS Protein of unknown function; null mutant forms abnormally large cells, and homozygous diploid null mutant displays delayed premeiotic DNA synthesis and reduced efficiency of meiotic nuclear division histone methylation|protein monoubiquitination|regulation of cell size|histone ubiquitination|premeiotic DNA replication molecular_function nucleus
YER020W YER020W GPA2 hom Verified 0.720950077356789 0.235470115325756 no 1200 0.218048524775293 744 NA FT SIGNALING|NUCLEOTIDE METABOLISM MITOCHONDRION|PLASMA MEMBRANE Nucleotide binding alpha subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p, has signaling role in response to nutrients; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery adenylate cyclase-activating G-protein coupled receptor signaling pathway|ascospore formation|replicative cell aging|signal transduction|glucose mediated signaling pathway|pseudohyphal growth|hexose mediated signaling|regulation of cell size GTPase activity mitochondrion|plasma membrane
YBR043C YBR043C QDR3 hom Verified 0.71940454581602 0.235945848390379 no 1201 0.210250368549173 711 NA FT PLASMA MEMBRANE Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; has a role in polyamine homeostasis; expression is upregulated under polyamine stress; required for resistance to quinidine, barban, cisplatin, and bleomycin drug transmembrane transport|polyamine homeostasis drug transmembrane transporter activity|polyamine transmembrane transporter activity integral to membrane|plasma membrane
YKR093W YKR093W PTR2 hom Verified 0.718737793857082 0.236151246046328 no 1202 0.265922801277579 954 NA FF|FT PROTEIN LOCALIZATION PLASMA MEMBRANE Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p dipeptide transport|tripeptide transport|peptide transport dipeptide transporter activity|tripeptide transporter activity|peptide transporter activity integral to membrane|plasma membrane
YDL173W YDL173W PAR32 hom Verified 0.717360028905535 0.236575988151664 no 1203 0.263597760975561 906 NA Putative protein of unknown function; hyperphosphorylated upon rapamycin treatment in a Tap42p-dependent manner; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; PAR32 is not an essential gene biological_process molecular_function cytoplasm
YPR153W YPR153W YPR153W hom Verified 0.716788052754938 0.236752442318719 no 1204 0.218932743491382 738 NA Putative protein of unknown function biological_process molecular_function integral to membrane
YKR018C YKR018C YKR018C hom Verified 0.71589559305415 0.23702790991573 no 1205 0.232735442786579 808 NA FT NUCLEUS|MITOCHONDRION Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress; YKR018C has a paralog, IML2, that arose from the whole genome duplication biological_process molecular_function nucleus|cytoplasm
YFL052W_p YFL052W YFL052W hom Uncharacterized 0.713580109016334 0.23774343044583 no 1206 0.209557948296837 704 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Putative zinc cluster protein that contains a DNA binding domain; computational analysis suggests a role as a transcription factor; null mutant is sensitive to Calcofluor White, low osmolarity, and heat, suggesting a role for YFL052Wp in cell wall integrity biological_process DNA binding cellular_component
YOR070C YOR070C GYP1 hom Verified 0.711890310863858 0.238266351253323 no 1207 0.319938396689646 1126 NA FF|FT VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM MITOCHONDRION|GOLGI APPARATUS Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion vesicle-mediated transport Rab GTPase activator activity mitochondrion|Golgi apparatus
YOR121C_d YOR121C YOR121C hom Dubious 0.710908313011199 0.238570527130691 no 1208 0.234053438794784 791 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GCY1/YOR120W Unknown Unknown Unknown
YER118C YER118C SHO1 hom Verified 0.709997719097282 0.238852775307906 no 1209 0.229787940036715 763 NA FT SIGNALING SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Transmembrane osmosensor involved in activation of the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway; phosphorylated by Hog1p; interacts with Pbs2p, Msb2p, Hkr1p, and Ste11p signal transduction involved in filamentous growth|establishment of cell polarity|osmosensory signaling pathway|cellular response to heat|cytokinesis osmosensor activity|MAP-kinase scaffold activity integral to membrane|plasma membrane|plasma membrane part|cellular bud|cellular bud neck|mating projection tip
YDR290W_d YDR290W YDR290W hom Dubious 0.709593398176875 0.238978157362915 no 1210 0.271342944621066 902 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RTT103 Unknown Unknown Unknown
YJL066C YJL066C MPM1 hom Verified 0.709390839389053 0.239040985441657 no 1211 0.252994061730541 865 NA FT MITOCHONDRION Mitochondrial intermembrane space protein of unknown function biological_process molecular_function mitochondrion|extrinsic to membrane
YOR058C YOR058C ASE1 hom Verified 0.709261880278321 0.23908098966 no 1212 0.205656302443749 717 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION NUCLEUS|CYTOSKELETON Mitotic spindle midzone localized protein; microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate; relative distribution to microtubules decreases upon DNA replication stress cytokinesis, completion of separation|mitotic anaphase B|microtubule bundle formation|spindle pole body separation|spindle midzone assembly|mitotic spindle stabilization|mitotic spindle elongation microtubule binding spindle midzone|nuclear microtubule|spindle
YML116W-A_d YML116W-A YML116W-A hom Dubious 0.708281333314768 0.239385283372223 no 1213 0.198137129237339 699 NA Putative protein of unknown function Unknown Unknown Unknown
YKR064W YKR064W OAF3 hom Verified 0.708235671573758 0.239399458759691 no 1214 0.25330285546084 847 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS|MITOCHONDRION Putative transcriptional repressor with Zn(2)-Cys(6) finger; negatively regulates transcription in response to oleate levels, based on mutant phenotype and localization to oleate-responsive promoters; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress negative regulation of transcription from RNA polymerase II promoter|cellular response to oleic acid RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity mitochondrion|nucleus|cytoplasm
YLR027C YLR027C AAT2 hom Verified 0.707163235005607 0.239732521436168 no 1215 0.284806069737744 936 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells aspartate biosynthetic process L-aspartate:2-oxoglutarate aminotransferase activity cytosol|peroxisome
YMR154C YMR154C RIM13 hom Verified 0.705696808204903 0.240188353156519 no 1216 0.247342429611876 843 NA FF|FT ION HOMEOSTASIS|PROTEOLYSIS|ION HOMEOSTASIS Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB protein processing cysteine-type endopeptidase activity cellular_component
YBR030W YBR030W RKM3 hom Verified 0.705518120887784 0.24024392951845 no 1217 0.209566418321659 719 NA FT NUCLEUS Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 40); nuclear SET domain containing protein peptidyl-lysine monomethylation protein-lysine N-methyltransferase activity nucleus
YNR030W YNR030W ALG12 hom Verified 0.704402319821914 0.240591130862962 no 1218 0.271888687735376 909 NA FT LIPID METABOLISM|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Alpha-1,6-mannosyltransferase localized to the ER; responsible for the addition of the alpha-1,6 mannose to dolichol-linked Man7GlcNAc2, acts in the dolichol pathway for N-glycosylation dolichol-linked oligosaccharide biosynthetic process|protein glycosylation alpha-1,6-mannosyltransferase activity integral to membrane|endoplasmic reticulum
YBL089W YBL089W AVT5 hom Verified 0.70420486973895 0.24065259940283 no 1219 0.270055585557008 898 NA Putative transporter; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; AVT5 has a paralog, AVT6, that arose from the whole genome duplication transport transporter activity integral to membrane
YLL002W YLL002W RTT109 hom Verified 0.7037060587406 0.240807923219411 no 1220 0.246734738130796 852 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS Histone acetyltransferase critical for cell survival in the presence of DNA damage during S phase; acetylates H3-K56 and H3-K9; involved in non-homologous end joining and in regulation of Ty1 transposition; interacts physically with Vps75p negative regulation of transposition, RNA-mediated|histone acetylation|double-strand break repair via nonhomologous end joining|response to DNA damage stimulus|regulation of transcription from RNA polymerase II promoter in response to stress H3 histone acetyltransferase activity nucleus
YDR391C_p YDR391C YDR391C hom Uncharacterized 0.703299210179288 0.240934651404251 no 1221 0.240714477222995 793 NA FT NUCLEUS Putative protein of unknown function, possibly involved in zinc homeostasis; Bdf1p-dependent transcription induced by salt stress; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus biological_process molecular_function nucleus|cytoplasm
YMR065W YMR065W KAR5 hom Verified 0.701522971076819 0.241488352096657 no 1222 0.23990217753465 839 NA FT ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION Protein required for nuclear membrane fusion during karyogamy, localizes to the membrane with a soluble portion in the endoplasmic reticulum lumen, may form a complex with Jem1p and Kar2p; expression of the gene is regulated by pheromone karyogamy involved in conjugation with cellular fusion molecular_function mitochondrion|endoplasmic reticulum membrane
YNL080C YNL080C EOS1 hom Verified 0.700990288600805 0.241654537914545 no 1223 0.259559707758273 865 NA FT CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein involved in N-glycosylation; deletion mutation confers sensitivity to exidative stress and shows synthetic lethality with mutations in the spindle checkpoint genes BUB3 and MAD1; YNL080C is not an essential gene cellular response to oxidative stress|protein N-linked glycosylation molecular_function integral to membrane|endoplasmic reticulum membrane
YBL078C YBL078C ATG8 hom Verified 0.700642204768721 0.241763166338719 no 1224 0.283921444901154 993 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS ENDOMEMBRANE SYSTEM Component of autophagosomes and Cvt vesicles; unique ubiquitin-like protein whose conjugation target is the lipid phosphatidylethanolamine (PE); Atg8p-PE is anchored to membranes, is involved in phagophore expansion, and may mediate membrane fusion during autophagosome formation; deconjugation of Atg8p-PE is required for efficient autophagosome biogenesis piecemeal microautophagy of nucleus|mitochondrion degradation|cellular membrane fusion|ER to Golgi vesicle-mediated transport|CVT pathway|autophagic vacuole assembly molecular_function cytosol|fungal-type vacuole membrane|pre-autophagosomal structure|extrinsic to membrane|autophagic vacuole
YCR095W-A_p YCR095W-A YCR095W-A hom Uncharacterized 0.70028768290031 0.241873831151427 no 1225 0.235719124318444 819 NA Putative protein of unknown function biological_process molecular_function cellular_component
YBR018C YBR018C GAL7 hom Verified 0.698220108706402 0.242519776359158 no 1226 0.241052262055124 842 NA FT CARBOHYDRATE METABOLISM Galactose-1-phosphate uridyl transferase, synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism galactose catabolic process via UDP-galactose UDP-glucose:hexose-1-phosphate uridylyltransferase activity cytoplasm
YEL038W YEL038W UTR4 hom Verified 0.696868815003088 0.24294244774052 no 1227 0.20143716978403 678 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Protein with sequence similarity to 2,3-diketo-5-methylthiopentyl-1-phosphate enolase-phosphatases, involved in methionine salvage; found in both the cytoplasm and nucleus L-methionine salvage from methylthioadenosine acireductone synthase activity nucleus|cytoplasm
YML054C-A_p YML054C-A YML054C-A hom Uncharacterized 0.696187599331017 0.243155676300135 no 1228 0.217903871774545 741 NA Putative protein of unknown function biological_process molecular_function cellular_component
YGR273C_p YGR273C YGR273C hom Uncharacterized 0.695864476317569 0.243256852994672 no 1229 0.25086412004849 858 NA Putative protein of unknown function; expression downregulated by treatment with 8-methoxypsoralen plus UVA irradiation; YGR273C is not an essential gene biological_process molecular_function cellular_component
YMR177W YMR177W MMT1 hom Verified 0.695641280046064 0.243326753785132 no 1230 0.244580969107492 869 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt2p cellular iron ion homeostasis molecular_function mitochondrion|integral to membrane
YIR034C YIR034C LYS1 hom Verified 0.69375505798374 0.243917915622152 no 1231 0.26370089200525 898 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS Saccharopine dehydrogenase (NAD+, L-lysine-forming), catalyzes the conversion of saccharopine to L-lysine, which is the final step in the lysine biosynthesis pathway; also has mRNA binding activity lysine biosynthetic process|lysine biosynthetic process via aminoadipic acid saccharopine dehydrogenase (NAD+, L-lysine-forming) activity|mRNA binding cytoplasm
YOR177C YOR177C MPC54 hom Verified 0.69360920359814 0.243963660177788 no 1232 0.254028365198892 863 NA FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION NUCLEUS|CYTOSKELETON Component of the meiotic outer plaque, a membrane-organizing center which is assembled on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; potential Cdc28p substrate ascospore wall assembly|vesicle docking structural molecule activity spindle pole body
YLR188W YLR188W MDL1 hom Verified 0.693349256350168 0.24404519934321 no 1233 0.253221098226327 858 NA FT NUCLEOTIDE METABOLISM MITOCHONDRION Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, mediates export of peptides generated upon proteolysis of mitochondrial proteins, plays a role in the regulation of cellular resistance to oxidative stress oligopeptide transport|oligopeptide export from mitochondrion ATPase activity|oligopeptide-transporting ATPase activity mitochondrion|integral to membrane|mitochondrial inner membrane
YOR109W YOR109W INP53 hom Verified 0.691298523258726 0.244688979827534 no 1234 0.238108640348693 822 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION CYTOSKELETON Polyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains phosphatidylinositol dephosphorylation phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|phosphatidylinositol-3-phosphatase activity|phosphatidylinositol-4-phosphate phosphatase activity membrane|actin cortical patch|cytoplasm
YEL020C_p YEL020C YEL020C hom Uncharacterized 0.690666534377184 0.244887562367473 no 1235 0.252311860469714 858 NA Protein of unknown function with low sequence identity to Pdc1p; mRNA identified as translated by ribosome profiling data biological_process molecular_function cytoplasm
YJL116C YJL116C NCA3 hom Verified 0.689085090290056 0.245384861032738 no 1236 0.230245544885777 762 NA FT MITOCHONDRION ORGANIZATION MITOCHONDRION Protein involved in mitochondrion organization; functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; member of the SUN family; expression induced in cells treated with the mycotoxin patulin; NCA3 has a paralog, UTH1, that arose from the whole genome duplication mitochondrion organization molecular_function cellular_component
YML074C YML074C FPR3 hom Verified 0.688992399649418 0.245414025228199 no 1237 0.222981011872881 730 NA FT CELL CYCLE|CHROMATIN ORGANIZATION NUCLEUS Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p meiotic recombination checkpoint peptidyl-prolyl cis-trans isomerase activity|macrolide binding nucleolus
YKL074C YKL074C MUD2 hom Verified 0.688052017053306 0.245710012615017 no 1238 0.213853982393552 719 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING NUCLEUS Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65 mRNA branch site recognition pre-mRNA branch point binding commitment complex
YLR174W YLR174W IDP2 hom Verified 0.687520808001573 0.24587729645732 no 1239 0.220399981516579 749 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM Cytosolic NADP-specific isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose; IDP2 has a paralog, IDP3, that arose from the whole genome duplication glutamate biosynthetic process|isocitrate metabolic process isocitrate dehydrogenase (NADP+) activity cytosol
YJR048W YJR048W CYC1 hom Verified 0.68617764596838 0.246300546167477 no 1240 0.214541452713655 716 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; CYC1 has a paralog, CYC7, that arose from the whole genome duplication mitochondrial electron transport, cytochrome c to oxygen|mitochondrial electron transport, ubiquinol to cytochrome c electron carrier activity mitochondrion|mitochondrial intermembrane space
YBR051W_d YBR051W YBR051W hom Dubious 0.686000548718236 0.246356381192379 no 1241 0.242276291861663 835 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partiallly overlaps the REG2/YBR050C regulatory subunit of the Glc7p type-1 protein phosphatase Unknown Unknown Unknown
YKL061W_p YKL061W BLI1 hom Uncharacterized 0.685899894573058 0.246388118343318 no 1242 0.235149081840607 785 NA Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome biological_process molecular_function endosome
YKR013W YKR013W PRY2 hom Verified 0.6855121265276 0.246510405550698 no 1243 0.272908085513711 946 NA Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY1; may be involved in detoxification of hydrophobic compounds; PRY2 has a paralog, PRY1, that arose from the whole genome duplication biological_process molecular_function extracellular region|fungal-type vacuole
YIL009C-A YIL009C-A EST3 hom Verified 0.684401008033032 0.246860989829165 no 1244 0.255834078411748 848 NA FT NUCLEUS|CHROMOSOME Component of the telomerase holoenzyme, involved in telomere replication telomere maintenance via telomerase ATP-dependent DNA/RNA helicase activity|GTPase activity|telomeric DNA binding chromosome, telomeric region|nucleus|telomerase holoenzyme complex
YPL168W_p YPL168W YPL168W hom Uncharacterized 0.682904829462565 0.247333491024697 no 1245 0.253514969477073 854 NA FT MITOCHONDRION Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; expression may be cell cycle-regulated biological_process molecular_function mitochondrion
YLR050C_p YLR050C YLR050C hom Uncharacterized 0.682700357737904 0.247398101817957 no 1246 0.241215435243598 830 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLR050C is not an essential gene biological_process molecular_function integral to membrane|endoplasmic reticulum
YDL094C_d YDL094C YDL094C hom Dubious 0.682542327315165 0.247448043855362 no 1247 0.223922530459603 784 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verfied gene PMT5/YDL093W; YDL094C is not essential Unknown Unknown Unknown
YDR161W_p YDR161W YDR161W hom Uncharacterized 0.681016694732309 0.247930463407486 no 1248 0.252042520756758 864 NA FT PROTEOLYSIS NUCLEUS Putative protein of unknown function; non-essential gene; proposed function in rRNA and ribosome biosynthesis based on transcriptional co-regulation; genetic interactions suggest a role in ER-associated protein degradation (ERAD) ER-associated protein catabolic process molecular_function nucleus|cytoplasm
YJL098W YJL098W SAP185 hom Verified 0.679783318499942 0.248320835333299 no 1249 0.24807398849691 850 NA FT CELL CYCLE|RNA PROCESSING MITOCHONDRION Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap190p; SAP185 has a paralog, SAP190, that arose from the whole genome duplication tRNA wobble uridine modification|G1/S transition of mitotic cell cycle protein serine/threonine phosphatase activity mitochondrion|cytoplasm
YER120W YER120W SCS2 hom Verified 0.678943523453025 0.248586823545401 no 1250 0.243933402615072 856 NA FT PROTEIN LOCALIZATION|LIPID METABOLISM|GENE SILENCING ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH Integral ER membrane protein, regulates phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PI4P levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; interacts with FFAT motif of Opi1p; involved in telomeric silencing; null shows inositol auxotrophy above 34 deg C; VAP homolog; SCS2 has a paralog, SCS22, that arose from the whole genome duplication endoplasmic reticulum inheritance|regulation of intracellular lipid transport|negative regulation of transcription factor import into nucleus|phospholipid biosynthetic process|chromatin silencing at telomere phosphatidylinositol binding|FFAT motif binding nuclear membrane|integral to endoplasmic reticulum membrane|nuclear envelope|endoplasmic reticulum|cellular bud tip
YGR168C_p YGR168C YGR168C hom Uncharacterized 0.677623977448878 0.249005069649362 no 1251 0.284320292535514 1004 NA Putative protein of unknown function; YGR168C is not an essential gene biological_process molecular_function integral to membrane
YKL157W YKL157W APE2 hom Verified 0.675180249039539 0.249780626750317 no 1252 0.258248872983104 844 NA FT PROTEOLYSIS MITOCHONDRION Aminopeptidase yscII; may have a role in obtaining leucine from dipeptide substrates; APE2 has a paralog, AAP1, that arose from the whole genome duplication peptide catabolic process metalloaminopeptidase activity mitochondrion|extracellular region|cell wall-bounded periplasmic space
YPR146C_d YPR146C YPR146C hom Dubious 0.674789464833861 0.249904767337227 no 1253 0.231595876736031 838 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YCR090C_p YCR090C YCR090C hom Uncharacterized 0.673832423201729 0.250208929416438 no 1254 0.202580505554206 692 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YCR090C is not an essential gene biological_process molecular_function nucleus|cytoplasm
YDL085W YDL085W NDE2 hom Verified 0.670984196534618 0.251115298564775 no 1255 0.229002341362586 762 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain glucose catabolic process to ethanol|NADH oxidation NADH dehydrogenase activity mitochondrion
YLR114C YLR114C AVL9 hom Verified 0.67003653410009 0.251417250463311 no 1256 0.264858594963736 909 NA FT VESICLE-MEDIATED TRANSPORT Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress post-Golgi vesicle-mediated transport molecular_function cytoplasm
YCR102C_p YCR102C YCR102C hom Uncharacterized 0.669907723501057 0.251458307951709 no 1257 0.252319131520401 902 NA FT OXIDATION-REDUCTION PROCESS Putative protein of unknown function, involved in copper metabolism; similar to C. carbonum toxD gene; member of the quinone oxidoreductase family response to copper ion molecular_function cellular_component
YOR044W YOR044W IRC23 hom Verified 0.669851901484028 0.251476101934365 no 1258 0.241944579525549 818 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; null mutant displays increased levels of spontaneous Rad52p foci; IRC23 has a paralog, BSC2, that arose from the whole genome duplication biological_process molecular_function endoplasmic reticulum
YMR092C YMR092C AIP1 hom Verified 0.669772120831802 0.251501534193764 no 1259 0.242059154152314 826 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON Actin cortical patch component; interacts with the actin depolymerizing factor cofilin; required to restrict cofilin localization to cortical patches; contains WD repeats; protein increases in abundance and relocalizes from cytoplasm to plasma membrane upon DNA replication stress actin filament depolymerization|response to osmotic stress actin binding nucleus|mating projection tip|cytoplasm|actin cortical patch
YNL301C YNL301C RPL18B hom Verified 0.669259728973984 0.251664905465847 no 1260 0.231850084881678 818 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L18B; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18B has a paralog, RPL18A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YKL037W YKL037W AIM26 hom Verified 0.668953294995297 0.251762635803632 no 1261 0.296518320427177 1015 NA FF|FT MITOCHONDRION Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT mitochondrion degradation molecular_function mitochondrion|integral to membrane
YDR179W-A_p YDR179W-A YDR179W-A hom Uncharacterized 0.667800328944628 0.252130528286828 no 1262 0.254856097513619 829 NA Putative protein of unknown function biological_process molecular_function cellular_component
YDR520C_p YDR520C URC2 hom Uncharacterized 0.666348638951399 0.252594141635145 no 1263 0.288303617373421 972 NA FT TRANSCRIPTION FROM RNA POL II|NUCLEOTIDE METABOLISM NUCLEUS Putative Zn(II)2Cys6 motif containing transcription factor; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; similar to S. kluyveri Urc2p involved in uracil catabolism uracil catabolic process sequence-specific DNA binding nucleus|cytoplasm
YBR114W YBR114W RAD16 hom Verified 0.664637918029579 0.25314105526899 no 1264 0.261484447638726 901 NA FT RESPONSE TO DNA DAMAGE|PROTEOLYSIS NUCLEUS UBIQUITIN LIGASE COMPLEX Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex nucleotide-excision repair, DNA damage recognition|protein ubiquitination involved in ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity|damaged DNA binding|DNA-dependent ATPase activity nucleotide-excision repair factor 4 complex|Cul3-RING ubiquitin ligase complex
YBL005W YBL005W PDR3 hom Verified 0.664597564504944 0.25315396371515 no 1265 0.246654080871768 857 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Transcriptional activator of the pleiotropic drug resistance network; regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements); post-translationally up-regulated in cells lacking a functional mitochondrial genome; PDR3 has a paralog, PDR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress Unknown|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus|cytoplasm
YBR286W YBR286W APE3 hom Verified 0.663836010949751 0.253397637401973 no 1266 0.260695780901543 915 NA FT PROTEOLYSIS Vacuolar aminopeptidase Y, processed to mature form by Prb1p vacuolar protein catabolic process aminopeptidase activity fungal-type vacuole
YGR178C YGR178C PBP1 hom Verified 0.66278398064402 0.253734457369399 no 1267 0.262857776062664 935 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION NUCLEUS|MITOCHONDRION Component of glucose deprivation induced stress granules; involved in P-body-dependent granule assembly; similar to human ataxin-2; interacts with Pab1p to regulate mRNA polyadenylation; interacts with Mkt1p to regulate HO translation; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress positive regulation of translation|mRNA polyadenylation|stress granule assembly molecular_function mitochondrion|nucleus|polysome|cytoplasmic stress granule|cytoplasm
YHR022C-A_p YHR022C-A YHR022C-A hom Uncharacterized 0.662682834228464 0.253766852975777 no 1268 0.247218089254801 864 NA Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YAL011W YAL011W SWC3 hom Verified 0.662328344867129 0.253880407484073 no 1269 0.292483987026911 989 NA FF|FT CHROMATIN ORGANIZATION NUCLEUS|MITOCHONDRION|CHROMOSOME Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae endoplasmic reticulum organization|chromatin remodeling|histone exchange molecular_function mitochondrion|Swr1 complex|nucleus
YDR131C_p YDR131C YDR131C hom Uncharacterized 0.660732894864138 0.254391812123896 no 1270 0.220986485717937 765 NA FT PROTEOLYSIS F-box protein, substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity|protein binding, bridging SCF ubiquitin ligase complex
YBR019C YBR019C GAL10 hom Verified 0.660326097081152 0.254522293182269 no 1271 0.24703904902669 842 NA FT CARBOHYDRATE METABOLISM UDP-glucose-4-epimerase, catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes the conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers galactose catabolic process via UDP-galactose aldose 1-epimerase activity|UDP-glucose 4-epimerase activity cytosol
YOL051W YOL051W GAL11 hom Verified 0.660014942632701 0.254622120145012 no 1272 0.319898046929337 1096 NA FF|FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors; forms part of the tail domain of mediator negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly|TFIIE-class binding transcription factor activity|RNA polymerase II activating transcription factor binding|TFIIE-class transcription factor binding|TFIIH-class transcription factor binding|RNA polymerase II transcription factor recruiting transcription factor activity core mediator complex
YJR055W YJR055W HIT1 hom Verified 0.659830246996783 0.254681385316695 no 1273 0.205181059399371 698 NA FT NUCLEUS Protein of unknown function, required for growth at high temperature biological_process molecular_function nucleus|cytoplasm
YOR354C YOR354C MSC6 hom Verified 0.659452763107504 0.254802534886487 no 1274 0.264411103921416 915 NA FT CELL CYCLE MITOCHONDRION Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies reciprocal meiotic recombination molecular_function mitochondrion
YOR346W YOR346W REV1 hom Verified 0.659151362985806 0.254899287810078 no 1275 0.230459393082615 752 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION|CHROMOSOME Deoxycytidyl transferase; involved in repair of abasic sites and adducted guanines in damaged DNA by translesion synthesis (TLS); forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; relocalizes from nucleus to cytoplasm upon DNA replication stress error-prone translesion synthesis|error-free translesion synthesis deoxycytidyl transferase activity|DNA-directed DNA polymerase activity nuclear chromatin|mitochondrion|replication fork
YLR173W_p YLR173W YLR173W hom Uncharacterized 0.659100076230615 0.254915753365439 no 1276 0.258179084985805 863 NA Putative protein of unknown function biological_process molecular_function cellular_component
YLR087C YLR087C CSF1 hom Verified 0.65541127261386 0.256101497828677 no 1277 0.316801336182881 1096 NA FF|FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies fermentation molecular_function mitochondrion
YOL140W YOL140W ARG8 hom Verified 0.655271088381334 0.256146615903531 no 1278 0.240517215707269 791 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine arginine biosynthetic process|ornithine biosynthetic process N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity mitochondrion|mitochondrial matrix
YKL043W YKL043W PHD1 hom Verified 0.654990024701801 0.256237088291883 no 1279 0.228520316765813 737 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Transcriptional activator that enhances pseudohyphal growth; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate; PHD1 has a paralog, SOK2, that arose from the whole genome duplication pseudohyphal growth|positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nucleus
YKL068W YKL068W NUP100 hom Verified 0.654268370411627 0.256469459926409 no 1280 0.241938814086973 842 NA FT PROTEIN LOCALIZATION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; homologous to Nup116p positive regulation of transcription, DNA-dependent|mRNA export from nucleus|NLS-bearing substrate import into nucleus|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|protein import into nucleus|protein targeting to nuclear inner membrane|mRNA export from nucleus in response to heat stress nucleocytoplasmic transporter activity|structural constituent of nuclear pore nuclear pore central transport channel|integral to membrane|nuclear pore
YGR040W YGR040W KSS1 hom Verified 0.653848018805979 0.256604863116268 no 1281 0.255458632426522 881 NA FT CELL CYCLE|SIGNALING|PROTEIN PHOSPHORYLATION NUCLEUS Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains pheromone-dependent signal transduction involved in conjugation with cellular fusion|signal transduction involved in filamentous growth|negative regulation of sequence-specific DNA binding transcription factor activity|protein phosphorylation|invasive growth in response to glucose limitation MAP kinase activity|protein kinase activity|transcription factor binding nucleus
YDR223W YDR223W CRF1 hom Verified 0.653006486684403 0.256876048333888 no 1282 0.2568526420172 876 NA FT TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS NUCLEUS|CHROMOSOME Transcriptional corepressor involved in repression of ribosomal protein (RP) gene transcription via the TOR signaling pathway which promotes accumulation of Crf1p in the nucleus; role in repression of RP genes varies by strain negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter transcription corepressor activity nuclear chromatin|nucleus|cytoplasm
YMR103C_d YMR103C YMR103C hom Dubious 0.652778719419244 0.256949472375968 no 1283 0.25472509544157 842 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOL063C YOL063C CRT10 hom Verified 0.652081672023509 0.257174243415743 no 1284 0.244259406779466 825 NA FT TRANSCRIPTION FROM RNA POL II Protein involved in transcriptional regulation of RNR2 and RNR3; expression of the gene is induced by DNA damage and null mutations confer increased resistance to hydroxyurea; N-terminal region has a leucine repeat and a WD40 repeat regulation of transcription from RNA polymerase II promoter molecular_function cellular_component
YIR020W-A_d YIR020W-A YIR020W-A hom Dubious 0.651660666448406 0.25731005106325 no 1285 0.270457094796029 959 NA Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data Unknown Unknown Unknown
YML106W YML106W URA5 hom Verified 0.651462826908168 0.257373882857602 no 1286 0.253933493772867 874 NA FT NUCLEOTIDE METABOLISM NUCLEUS Major orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA5 has a paralog, URA10, that arose from the whole genome duplication 'de novo' pyrimidine nucleobase biosynthetic process|pyrimidine ribonucleoside biosynthetic process orotate phosphoribosyltransferase activity nucleus|cytoplasm
YJL144W YJL144W YJL144W hom Verified 0.651121004274952 0.257484189359348 no 1287 0.247525659917258 849 NA Cytoplasmic hydrophilin essential in dessication-rehydration process; expression induced by osmotic stress, starvation and during stationary phase; protein abundance increases in response to DNA replication stress cellular response to water deprivation molecular_function cytoplasm
YCR082W YCR082W AHC2 hom Verified 0.649590748142687 0.25797830542224 no 1288 0.265341523179865 920 NA FT CHROMATIN ORGANIZATION NUCLEUS HISTONE ACETYLTRANSFERASE Component of the ADA histone acetyltransferase complex; Ach2p and Ach1p are unique to the ADA complex and not shared with the related SAGA and SLIK complexes; may tether Ach1p to the complex histone acetylation histone acetyltransferase activity Ada2/Gcn5/Ada3 transcription activator complex|nucleus|cytoplasm
YLR374C_d YLR374C YLR374C hom Dubious 0.649414847054489 0.258035134967993 no 1289 0.31224540185145 1059 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF STP3/YLR375W Unknown Unknown Unknown
YGR237C_p YGR237C YGR237C hom Uncharacterized 0.648893846953982 0.258203496056931 no 1290 0.248945290606065 838 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm biological_process molecular_function cytoplasm
YGR033C YGR033C TIM21 hom Verified 0.647645040963502 0.258607279200022 no 1291 0.248561866338169 836 NA FT PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Nonessential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); interacts with the Translocase of the Outer Mitochondrial membrane (TOM complex) and with respiratory enzymes; may regulate TIM23 complex activity protein import into mitochondrial matrix molecular_function mitochondrion|mitochondrial inner membrane presequence translocase complex
YHR150W YHR150W PEX28 hom Verified 0.646810882076697 0.258877174290264 no 1292 0.229961206304447 800 NA FT PEROXISOME ORGANIZATION Peroxisomal integral membrane peroxin, involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p peroxisome organization molecular_function integral to membrane|peroxisomal membrane
YNL288W YNL288W CAF40 hom Verified 0.646400206036754 0.259010103506474 no 1293 0.262096923329722 896 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter molecular_function CCR4-NOT core complex
YGL050W YGL050W TYW3 hom Verified 0.645178964884651 0.259405608057675 no 1294 0.25812976333278 872 NA FT RNA PROCESSING tRNA methyltransferase required for synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions tRNA methylation|wybutosine biosynthetic process tRNA methyltransferase activity cellular_component
YPL019C YPL019C VTC3 hom Verified 0.645125167035911 0.259423037909402 no 1295 0.23274927537492 779 NA FT MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT ENDOPLASMIC RETICULUM Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion polyphosphate metabolic process|vacuolar transport|microautophagy|vacuole fusion, non-autophagic molecular_function fungal-type vacuole membrane|integral to membrane|vacuolar transporter chaperone complex|endoplasmic reticulum
YLR423C YLR423C ATG17 hom Verified 0.645092669390275 0.259433567046264 no 1296 0.273083728880263 938 NA FT MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION Scaffold protein responsible for phagophore assembly site organization; regulatory subunit of an autophagy-specific complex that includes Atg1p and Atg13p; stimulates Atg1p kinase activity; human ortholog RB1CC1/FIP200 interacts with p53, which inhibits autophagy in human cells piecemeal microautophagy of nucleus|mitochondrion degradation|peroxisome degradation|activation of protein kinase activity|autophagic vacuole assembly protein kinase activator activity|protein complex scaffold pre-autophagosomal structure|Atg1p signaling complex
YPL197C_d YPL197C YPL197C hom Dubious 0.643684112247718 0.259890147249219 no 1297 0.271834547285931 916 NA Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the ribosomal gene RPB7B Unknown Unknown Unknown
YML111W YML111W BUL2 hom Verified 0.6431980105242 0.260047812035109 no 1298 0.248091593614621 863 NA FT UBIQUITIN LIGASE COMPLEX Component of the Rsp5p E3-ubiquitin ligase complex; involved in intracellular amino acid permease sorting, functions in heat shock element mediated gene expression, essential for growth in stress conditions; BUL2 has a paralog, BUL1, that arose from the whole genome duplication protein polyubiquitination|protein monoubiquitination ubiquitin-ubiquitin ligase activity ubiquitin ligase complex|cytoplasm
YDL053C YDL053C PBP4 hom Verified 0.641003127356042 0.260760325547163 no 1299 0.267629691290251 928 NA FT NUCLEUS Pbp1p binding protein; interacts strongly with Pab1p-binding protein 1 (Pbp1p) in the yeast two-hybrid system; also interacts with Lsm12p in a copurification assay; relative distribution to the nucleus increases upon DNA replication stress biological_process molecular_function nucleus|cytoplasmic stress granule|cytoplasm
YCR101C_p YCR101C YCR101C hom Uncharacterized 0.640369500621713 0.260966203187714 no 1300 0.261984217590928 923 NA Putative protein of unknown function; localizes to the membrane fraction; YCR101C is not an essential gene biological_process molecular_function integral to membrane|membrane
YBR238C YBR238C YBR238C hom Verified 0.639757981189549 0.261164976967654 no 1301 0.299490095877455 1020 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Mitochondrial membrane protein with similarity to Rmd9p; not required for respiratory growth but causes a synthetic respiratory defect in combination with rmd9 mutations; transcriptionally up-regulated by TOR; deletion increases life span aerobic respiration molecular_function mitochondrion|integral to mitochondrial membrane|cytoplasm
YOR012W_p YOR012W YOR012W hom Uncharacterized 0.639056043424213 0.261393237015034 no 1302 0.211761596048966 712 NA Putative protein of unknown function biological_process molecular_function cellular_component
YJR003C_p YJR003C YJR003C hom Uncharacterized 0.638444843894572 0.261592073710341 no 1303 0.263268814271438 914 NA FT MITOCHONDRION Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; predicted to be involved in ribosome biogenesis biological_process molecular_function mitochondrion
YKL115C_d YKL115C YKL115C hom Dubious 0.638229658540181 0.261662096728068 no 1304 0.251899796781646 890 NA Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1 Unknown Unknown Unknown
YJL027C_p YJL027C YJL027C hom Uncharacterized 0.638082311186124 0.261710050271061 no 1305 0.246835588394159 838 NA Putative protein of unknown function biological_process molecular_function cellular_component
YNR014W_p YNR014W YNR014W hom Uncharacterized 0.637225172575466 0.261989091612005 no 1306 0.276223749574666 928 NA Putative protein of unknown function; expression is cell-cycle regulated, Azf1p-dependent, and heat-inducible; YNR014W has a paralog, YMR206W, that arose from the whole genome duplication biological_process molecular_function cytoplasm
YNL111C YNL111C CYB5 hom Verified 0.636071403754055 0.262364941568297 no 1307 0.304055712497357 1049 NA FF|FT LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation sterol biosynthetic process electron carrier activity endoplasmic reticulum membrane
YDR421W YDR421W ARO80 hom Verified 0.635174870591853 0.262657185356103 no 1308 0.22754669539521 753 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Zinc finger transcriptional activator of the Zn2Cys6 family; activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids aromatic amino acid family catabolic process|positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|nucleic acid binding transcription factor activity nucleus
YDR432W YDR432W NPL3 hom Verified 0.634906889144834 0.262744571851519 no 1309 0.291800380497458 1009 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION NUCLEUS RNA-binding protein; promotes elongation, regulates termination, and carries poly(A) mRNA from nucleus to cytoplasm; has a role in repressing translation initiation by binding eIF4G; required for pre-mRNA splicing; dissociation from mRNAs promoted by Mtr10p; phosphorylated by Sky1p in the cytoplasm; protein abundance increases in response to DNA replication stress translational termination|mRNA export from nucleus|negative regulation of translation|mRNA splicing, via spliceosome|Unknown|positive regulation of transcription elongation from RNA polymerase II promoter mRNA binding|RNA polymerase II core binding|eukaryotic initiation factor 4G binding|poly(A) RNA binding nucleus|cytoplasm
YDR528W YDR528W HLR1 hom Verified 0.632315716337857 0.263590297937122 no 1310 0.239884166370714 786 NA FT CELL WALL ORG/BIOGENESIS Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A;
HLR1 has a paralog, LRE1, that arose from the whole genome duplication fungal-type cell wall organization molecular_function cytoplasm
YJR005W YJR005W APL1 hom Verified 0.63169023658693 0.263794654542358 no 1311 0.259182337110358 914 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|PLASMA MEMBRANE Beta-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport; similar to mammalian beta-chain of the clathrin associated protein complex vesicle-mediated transport molecular_function AP-2 adaptor complex
YLR429W YLR429W CRN1 hom Verified 0.631199895025841 0.263954915302084 no 1312 0.249465755716398 862 NA FT CYTOSKELETON ORGANIZATION CYTOSKELETON Coronin, cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity; plays a role in regulation of actin patch assembly microtubule-based process|actin filament organization|actin cortical patch localization|Unknown|negative regulation of Arp2/3 complex-mediated actin nucleation microtubule binding|actin filament binding|protein binding, bridging Arp2/3 protein complex|actin cortical patch
YGR008C YGR008C STF2 hom Verified 0.630138349787429 0.264302035310319 no 1313 0.264902424114155 904 NA FT MITOCHONDRION Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress cellular response to desiccation molecular_function cytoplasm
YDR215C_d YDR215C YDR215C hom Dubious 0.628917087122289 0.26470166943054 no 1314 0.266468631019594 868 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein Unknown Unknown Unknown
YGR270W YGR270W YTA7 hom Verified 0.628278119535003 0.26491088135106 no 1315 0.307737864273022 1070 NA FT TRANSCRIPTION FROM RNA POL II|GENE SILENCING ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Protein that localizes to chromatin and has a role in regulation of histone gene expression; has a bromodomain-like region that interacts with the N-terminal tail of histone H3, and an ATPase domain; potentially phosphorylated by Cdc28p negative regulation of transcription from RNA polymerase II promoter|negative regulation of chromatin silencing|positive regulation of transcription from RNA polymerase II promoter chromatin binding|histone binding extrinsic to endoplasmic reticulum membrane|nucleus
YDR147W YDR147W EKI1 hom Verified 0.627330390252867 0.265221343269211 no 1316 0.268292063918971 894 NA FT LIPID METABOLISM Ethanolamine kinase; primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; exhibits some choline kinase activity, thus contributing to phosphatidylcholine synthesis via the CDP-choline pathway; EKI1 has a paralog, CKI1, that arose from the whole genome duplication phosphatidylethanolamine biosynthetic process|phosphatidylcholine biosynthetic process ethanolamine kinase activity|choline kinase activity cytoplasm
YIR035C_p YIR035C YIR035C hom Uncharacterized 0.627117566288102 0.265291086605125 no 1317 0.239383676904596 827 NA FT OXIDATION-REDUCTION PROCESS Putative cytoplasmic short-chain dehydrogenase/reductase biological_process molecular_function integral to membrane|cytoplasm
YOR201C YOR201C MRM1 hom Verified 0.625326220884496 0.26587848700185 no 1318 0.269863805381382 907 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS MITOCHONDRION Ribose methyltransferase that modifies a functionally critical, conserved nucleotide in mitochondrial 21S rRNA rRNA modification rRNA (guanine-N1-)-methyltransferase activity mitochondrion
YJL129C YJL129C TRK1 hom Verified 0.624738775128029 0.266071259852974 no 1319 0.308564817421995 1050 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication cellular potassium ion homeostasis potassium ion transmembrane transporter activity membrane raft|integral to membrane|plasma membrane
YFR054C_d YFR054C YFR054C hom Dubious 0.624031270480504 0.266303524472749 no 1320 0.238692465079123 830 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YKL130C YKL130C SHE2 hom Verified 0.623620276713753 0.266438495509512 no 1321 0.235836355198495 801 NA FT RNA LOCALIZATION NUCLEUS|SITE OF POLARIZED GROWTH RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud mating type switching|intracellular mRNA localization mRNA binding cellular bud tip|cytoplasm
YML051W YML051W GAL80 hom Verified 0.622203891807661 0.266903903652251 no 1322 0.267297297068093 894 NA FT TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM NUCLEUS Transcriptional regulator involved in the repression of GAL genes in the absence of galactose; inhibits transcriptional activation by Gal4p; inhibition relieved by Gal3p or Gal1p binding negative regulation of kinase activity|galactose metabolic process|negative regulation of transcription from RNA polymerase II promoter|negative regulation of sequence-specific DNA binding transcription factor activity RNA polymerase II activating transcription factor binding|kinase inhibitor activity nucleus|cytoplasm
YLR126C YLR126C YLR126C hom Verified 0.620758825557123 0.26737915904164 no 1323 0.256889972549278 893 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS Putative glutamine amidotransferase; has Aft1p-binding motif in the promoter; may be involved in copper and iron homeostasis; YLR126C is not an essential protein; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress cellular copper ion homeostasis|cellular iron ion homeostasis molecular_function cytoplasm
YBL099W YBL099W ATP1 hom Verified 0.6197336561455 0.267716576832415 no 1324 0.27838646643428 996 NA FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS MITOCHONDRION Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated ATP synthesis coupled proton transport hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism mitochondrial nucleoid|proton-transporting ATP synthase complex, catalytic core F(1)|mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase, catalytic core
YMR285C YMR285C NGL2 hom Verified 0.618660988826579 0.268069857354723 no 1325 0.244073986369433 808 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p; NGL2 has a paralog, NGL3, that arose from the whole genome duplication rRNA processing endoribonuclease activity intracellular
YPR129W YPR129W SCD6 hom Verified 0.617077480868578 0.268591810643125 no 1326 0.292017353318913 995 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION Repressor of translation initiation; binds eIF4G through its RGG domain and inhibits recruitment of the preinitiation complex; also contains an Lsm domain; may have a role in RNA processing; overproduction suppresses null mutation in clathrin heavy chain gene CHC1; forms cytoplasmic foci upon DNA replication stress stress granule assembly|negative regulation of translational initiation|cytoplasmic mRNA processing body assembly mRNA binding|RNA binding|eukaryotic initiation factor 4G binding cytoplasmic mRNA processing body|cytoplasmic stress granule|cytoplasm
YPL135W YPL135W ISU1 hom Verified 0.615780734032023 0.2690196222701 no 1327 0.276238922878656 948 NA FT RNA PROCESSING|ION HOMEOSTASIS|ION HOMEOSTASIS|COFACTOR METABOLISM MITOCHONDRION Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable cellular iron ion homeostasis|iron-sulfur cluster assembly|tRNA wobble uridine modification ferrous iron binding mitochondrion|mitochondrial matrix
YMR144W_p YMR144W YMR144W hom Uncharacterized 0.615656444479704 0.269060644771003 no 1328 0.264195014138937 866 NA FT NUCLEUS Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene biological_process molecular_function nucleus
YMR140W YMR140W SIP5 hom Verified 0.614316218949145 0.269503193469428 no 1329 0.25425340499219 881 NA FT RESPONSE TO NUTRIENT LEVELS Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase; forms cytoplasmic foci upon DNA replication stress cellular response to glucose starvation molecular_function cytoplasm
YGR208W YGR208W SER2 hom Verified 0.61423427258379 0.269530264370236 no 1330 0.25714527750619 878 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source L-serine biosynthetic process phosphoserine phosphatase activity nucleus|cytoplasm
YBR262C YBR262C AIM5 hom Verified 0.611942307990675 0.270287964222555 no 1331 0.220853599769319 727 NA FT MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture cristae formation molecular_function mitochondrion|mitochondrial crista junction|integral to mitochondrial inner membrane
YOR047C YOR047C STD1 hom Verified 0.609842694040291 0.270983008325776 no 1332 0.278332318008948 937 NA FT TRANSCRIPTION FROM RNA POL II|SIGNALING|CARBOHYDRATE METABOLISM NUCLEUS|PLASMA MEMBRANE Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+] response to salt stress|signal transduction|nicotinamide riboside biosynthetic process|glucose metabolic process|nicotinic acid riboside biosynthetic process|regulation of transcription from RNA polymerase II promoter protein kinase activator activity plasma membrane|nucleus
YHR141C YHR141C RPL42B hom Verified 0.608312238162525 0.271490202874296 no 1333 0.294762135735333 974 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L42B; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus; homologous to mammalian ribosomal protein L36A, no bacterial homolog; RPL42B has a paralog, RPL42A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YNR020C YNR020C ATP23 hom Verified 0.607663131534222 0.271705460149756 no 1334 0.28837552722813 983 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Putative metalloprotease of the mitochondrial inner membrane, required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex; substrate of the Mia40p-Erv1p disulfide relay system, and folding is assisted by Mia40p protein processing|mitochondrial proton-transporting ATP synthase complex assembly metalloendopeptidase activity mitochondrial inner membrane|mitochondrial intermembrane space
YBR147W YBR147W RTC2 hom Verified 0.607014401213908 0.271920677482256 no 1335 0.251793015630209 852 NA FT MITOCHONDRION Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; positive regulation by Lys14p suggests that lysine may be the primary substrate; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter biological_process molecular_function mitochondrion|integral to membrane
YJL117W YJL117W PHO86 hom Verified 0.606053425122517 0.272239638622624 no 1336 0.258210247683755 896 NA FT VESICLE-MEDIATED TRANSPORT|ION HOMEOSTASIS|ION HOMEOSTASIS ENDOPLASMIC RETICULUM Endoplasmic reticulum (ER) resident protein; required for ER exit of the high-affinity phosphate transporter Pho84p, specifically required for packaging of Pho84p into COPII vesicles; protein abundance increases in response to DNA replication stress protein folding|ER to Golgi vesicle-mediated transport|regulation of phosphate transport unfolded protein binding endoplasmic reticulum
YBR182C YBR182C SMP1 hom Verified 0.605198318428981 0.272523616502717 no 1337 0.256547339615945 899 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Putative transcription factor of the MADS-box family; involved in regulating the response to osmotic stress; SMP1 has a paralog, RLM1, that arose from the whole genome duplication positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress DNA binding, bending|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nucleus|cytoplasm
YCR105W YCR105W ADH7 hom Verified 0.60511937287645 0.272549841453008 no 1338 0.293453815479229 987 NA FT OXIDATION-REDUCTION PROCESS NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance alcohol metabolic process alcohol dehydrogenase (NADP+) activity cellular_component
YHR135C YHR135C YCK1 hom Verified 0.604768968723286 0.272666257449212 no 1339 0.267927545057444 924 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL DIVISION|PROTEIN PHOSPHORYLATION ENDOPLASMIC RETICULUM|MITOCHONDRION|PLASMA MEMBRANE Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; YCK1 has a paralog, YCK2, that arose from the whole genome duplication cell morphogenesis|endocytosis|protein phosphorylation|cytokinesis|response to glucose stimulus protein serine/threonine kinase activity|protein kinase activity mitochondrion|endoplasmic reticulum|plasma membrane
YGL148W YGL148W ARO2 hom Verified 0.604718586173332 0.27268299824886 no 1340 0.353609749703647 1183 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM Bifunctional chorismate synthase and flavin reductase; catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids; protein abundance increases in response to DNA replication stress aromatic amino acid family biosynthetic process chorismate synthase activity|riboflavin reductase (NADPH) activity cytoplasm
YPL189W YPL189W GUP2 hom Verified 0.604321517481633 0.272814951606478 no 1341 0.220201807015324 711 NA Probable membrane protein with a possible role in proton symport of glycerol; member of the MBOAT family of putative membrane-bound O-acyltransferases; Gup1p homolog glycerol transport O-acyltransferase activity integral to membrane|membrane
YDR313C YDR313C PIB1 hom Verified 0.603766739472655 0.272999367750088 no 1342 0.272037968416716 919 NA RING-type ubiquitin ligase of the endosomal and vacuolar membranes, binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain protein ubiquitination ubiquitin-protein ligase activity|phosphatidylinositol-3-phosphate binding fungal-type vacuole membrane|late endosome
YKL023W_p YKL023W YKL023W hom Uncharacterized 0.60182362168594 0.273645774804396 no 1343 0.266474267259445 932 NA Putative protein of unknown function, predicted by computational methods to be involved in mRNA degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm biological_process molecular_function cytoplasm
YJL150W_d YJL150W YJL150W hom Dubious 0.60174903508594 0.273670602230677 no 1344 0.248227544306893 874 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR048C_d YDR048C YDR048C hom Dubious 0.601369670629112 0.273796897428418 no 1345 0.275976176617315 969 NA Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YJR106W YJR106W ECM27 hom Verified 0.600335027491755 0.274141489569193 no 1346 0.247243322724842 844 NA FT CELL WALL ORG/BIOGENESIS Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants are hypersensitive to Papulacandin B; null mutants have increased plasmid loss; displays a two-hybrid interaction with Pdr5p fungal-type cell wall organization molecular_function integral to membrane
YLR330W YLR330W CHS5 hom Verified 0.600234933810241 0.2741748375425 no 1347 0.316641636837503 1084 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM GOLGI APPARATUS|SITE OF POLARIZED GROWTH Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane ascospore wall assembly|conjugation with cellular fusion|cell wall chitin catabolic process|Golgi to plasma membrane transport|cellular bud site selection|regulation of transcription, DNA-dependent molecular_function mating projection tip|cytoplasm|exomer complex
YMR210W YMR210W YMR210W hom Verified 0.600106264520207 0.274217708926415 no 1348 0.240483806079974 789 NA FT KETONE METABOLISM|LIPID METABOLISM Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification medium-chain fatty acid biosynthetic process transferase activity, transferring acyl groups cellular_component
YKR061W YKR061W KTR2 hom Verified 0.598419874446829 0.274779903917914 no 1349 0.259618954177186 891 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Mannosyltransferase involved in N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR2 has a paralog, YUR1, that arose from the whole genome duplication cell wall mannoprotein biosynthetic process|protein N-linked glycosylation mannosyltransferase activity Golgi apparatus
YGR007W YGR007W ECT1 hom Verified 0.59693311176125 0.275276019611817 no 1350 0.280421142251902 939 NA FT LIPID METABOLISM NUCLEUS Ethanolamine-phosphate cytidylyltransferase, catalyzes the second step of phosphatidylethanolamine biosynthesis; involved in the maintenance of plasma membrane; similar to mammalian CTP: phosphocholine cytidylyl-transferases phosphatidylethanolamine biosynthetic process ethanolamine-phosphate cytidylyltransferase activity nucleus|cytoplasm
YLR320W YLR320W MMS22 hom Verified 0.595556499311363 0.275735772201237 no 1351 0.27724506554657 965 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS UBIQUITIN LIGASE COMPLEX Subunit of an E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of the replication fork, such as the fork-pausing complex and leading strand polymerase, preventing fork collapse and promoting efficient recovery during replication stress; required for accurate meiotic chromosome segregation replication fork processing|double-strand break repair|recombinational repair|meiotic sister chromatid segregation|response to DNA damage stimulus molecular_function Cul8-RING ubiquitin ligase complex|nucleus
YOR006C YOR006C TSR3 hom Verified 0.593182877904665 0.276529385044356 no 1352 0.305879715865082 1019 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Protein required for 20S pre-rRNA processing; involved in processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress maturation of SSU-rRNA molecular_function nucleus|cytoplasm
YDL095W YDL095W PMT1 hom Verified 0.593149336158061 0.276540607640759 no 1353 0.303727052925499 1058 NA FT PROTEIN LOCALIZATION|CARBOHYDRATE METABOLISM|PROTEOLYSIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein O-mannosyltransferase of the ER membrane; transfers mannose from dolichyl phosphate-D-mannose to protein serine and threonine residues; 1 of 7 related proteins involved in O-glycosylation which is essential for cell wall rigidity; involved in ER quality control; amino terminus faces cytoplasm, carboxyl terminus faces ER lumen ER-associated misfolded protein catabolic process|Unknown|protein exit from endoplasmic reticulum|protein O-linked mannosylation dolichyl-phosphate-mannose-protein mannosyltransferase activity integral to membrane|dolichyl-phosphate-mannose-protein mannosyltransferase complex
YOL096C YOL096C COQ3 hom Verified 0.590052411115954 0.27757775612724 no 1354 0.27605409626109 986 NA FT KETONE METABOLISM|COFACTOR METABOLISM MITOCHONDRION O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein ubiquinone biosynthetic process hexaprenyldihydroxybenzoate methyltransferase activity mitochondrion|mitochondrial inner membrane|extrinsic to membrane
YNL043C_d YNL043C YNL043C hom Dubious 0.58778833248281 0.278337188211052 no 1355 0.282872307530108 971 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W Unknown Unknown Unknown
YML119W_p YML119W YML119W hom Uncharacterized 0.587787727707636 0.278337391203922 no 1356 0.277064931717589 931 NA Putative protein of unknown function; YML119W is not an essential gene; potential Cdc28p substrate biological_process molecular_function cellular_component
YDL075W YDL075W RPL31A hom Verified 0.585100997962106 0.279239903937338 no 1357 0.306448393051304 1049 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L31A; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31A has a paralog, RPL31B, that arose from the whole genome duplication cytoplasmic translation|regulation of translational fidelity structural constituent of ribosome cytosolic large ribosomal subunit
YPR123C_d YPR123C YPR123C hom Dubious 0.582514574742393 0.280110063605429 no 1358 0.383088814812551 1263 NA FF Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CTR Unknown Unknown Unknown
YJL082W YJL082W IML2 hom Verified 0.581815024099546 0.280345641522455 no 1359 0.262855237894224 893 NA FT NUCLEUS|MITOCHONDRION Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; IML2 has a paralog, YKR018C, that arose from the whole genome duplication biological_process molecular_function mitochondrial outer membrane|mitochondrion|nucleus|cytoplasm
YMR205C YMR205C PFK2 hom Verified 0.5802970973677 0.280857142256716 no 1360 0.396940898170212 1299 NA FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes proton transport|glycolysis mRNA binding|6-phosphofructokinase activity mitochondrion|6-phosphofructokinase complex|cytoplasm
YOR284W YOR284W HUA2 hom Verified 0.57717202566989 0.281911626286547 no 1361 0.279032174645123 937 NA Cytoplasmic protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly biological_process molecular_function cytoplasm
YDL201W YDL201W TRM8 hom Verified 0.576346368421591 0.282190543662917 no 1362 0.262262555482236 889 NA FT RNA PROCESSING NUCLEUS Noncatalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p tRNA methylation tRNA (guanine-N7-)-methyltransferase activity tRNA methyltransferase complex|nucleus
YDR321W YDR321W ASP1 hom Verified 0.57613079011873 0.282263390580017 no 1363 0.274990815083221 947 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Cytosolic L-asparaginase, involved in asparagine catabolism; catalyzes hydrolysis of L-asparagine to aspartic acid and ammonia, has an important role in therapy of acute lymphoblastic leukemia; synthesized constitutively asparagine catabolic process asparaginase activity intracellular
YEL064C YEL064C AVT2 hom Verified 0.575862378158808 0.28235410337319 no 1364 0.256434540399662 882 NA FT ENDOPLASMIC RETICULUM Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters transport transporter activity integral to membrane|endoplasmic reticulum
YDL127W YDL127W PCL2 hom Verified 0.575726184286541 0.282400136962901 no 1365 0.23310274140828 817 NA FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION NUCLEUS|SITE OF POLARIZED GROWTH Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; localizes to sites of polarized cell growth G1 phase of mitotic cell cycle|regulation of establishment or maintenance of cell polarity|regulation of cyclin-dependent protein kinase activity|septin ring organization cyclin-dependent protein kinase regulator activity cyclin-dependent protein kinase holoenzyme complex|incipient cellular bud site|nucleus|cellular bud neck|cellular bud tip
YNR013C YNR013C PHO91 hom Verified 0.575303626079236 0.282542984796765 no 1366 0.297704829105317 1001 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth phosphate ion transport|polyphosphate metabolic process phosphate ion transmembrane transporter activity fungal-type vacuole membrane|integral to membrane|membrane
YGR180C YGR180C RNR4 hom Verified 0.575183490217673 0.282583603643852 no 1367 0.319502992571849 1059 NA FT OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM NUCLEUS Ribonucleotide-diphosphate reductase (RNR) small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits; relocalizes from nucleus to cytoplasm upon DNA replication stress cofactor biosynthetic process|deoxyribonucleotide biosynthetic process ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor ribonucleoside-diphosphate reductase complex|nucleus|cytoplasm
YLL047W_d YLL047W YLL047W hom Dubious 0.574130515774445 0.28293974237234 no 1368 0.295169858579745 1025 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RNP1 Unknown Unknown Unknown
YDR017C YDR017C KCS1 hom Verified 0.573708856219294 0.283082417156831 no 1369 0.254964707637225 875 NA Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response and telomere maintenance inositol phosphate biosynthetic process inositol heptakisphosphate kinase activity|inositol hexakisphosphate kinase activity|inositol-1,3,4,5,6-pentakisphosphate kinase activity|inositol heptakisphosphate 5-kinase activity cytoplasm
YEL028W_d YEL028W YEL028W hom Dubious 0.573018894848596 0.28331595029774 no 1370 0.301680720683593 1048 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGR227W YGR227W DIE2 hom Verified 0.572831372917345 0.283379437329865 no 1371 0.282107123645015 990 NA FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Dolichyl-phosphoglucose-dependent alpha-1,2 glucosyltransferase of the ER, functions in the pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation, has a role in regulation of ITR1 and INO1 dolichol-linked oligosaccharide biosynthetic process|protein N-linked glycosylation dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity integral to membrane|endoplasmic reticulum membrane
YNL265C YNL265C IST1 hom Verified 0.57234657257918 0.283543601920608 no 1372 0.296163669070929 1018 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT Protein with a positive role in the multivesicular body sorting pathway; functions and forms a complex with Did2p; recruitment to endosomes is mediated by the Vps2p-Vps24p subcomplex of ESCRT-III; also interacts with Vps4p late endosome to vacuole transport via multivesicular body sorting pathway molecular_function endosome|cytoplasm
YPR013C_p YPR013C CMR3 hom Uncharacterized 0.572145129155029 0.283611828715677 no 1373 0.275956401529052 941 NA Putative zinc finger protein; YPR013C is not an essential gene biological_process sequence-specific DNA binding cellular_component
YOR350C YOR350C MNE1 hom Verified 0.570562484331882 0.284148127519471 no 1374 0.288233328829761 986 NA FT RNA PROCESSING MITOCHONDRION Mitochondrial matrix protein involved in splicing Group I aI5-beta intron from COX1 mRNA Group I intron splicing molecular_function mitochondrion|ribonucleoprotein complex|mitochondrial matrix
YOR318C_d YOR318C YOR318C hom Dubious 0.570387918046211 0.284207311151547 no 1375 0.27975232384274 957 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo Unknown Unknown Unknown
YOL143C YOL143C RIB4 hom Verified 0.570386436693429 0.284207813403399 no 1376 0.306461070380275 1055 NA FT NUCLEUS Lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, also known as DMRL synthase); catalyzes synthesis of immediate precursor to riboflavin riboflavin biosynthetic process 6,7-dimethyl-8-ribityllumazine synthase activity nucleus|cytoplasm
YPL005W YPL005W AEP3 hom Verified 0.570004935595086 0.284337175268385 no 1377 0.274717199186225 936 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Protein that may facilitate use of unformylated tRNA-Met in mitochondrial translation initiation; localized to the matrix face of the mitochondrial inner membrane; stabilizes the bicistronic AAP1-ATP6 mRNA mRNA metabolic process|mitochondrial translational initiation molecular_function mitochondrion|mitochondrial inner membrane|cytoplasm|extrinsic to membrane
YLL007C_p YLL007C YLL007C hom Uncharacterized 0.569977078755425 0.284346622248426 no 1378 0.300994129033902 1075 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL007C is not an essential gene biological_process molecular_function cytoplasm
YML047W-A_d YML047W-A YML047W-A hom Dubious 0.569971226542437 0.284348606905376 no 1379 0.282080002035817 918 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YNL191W YNL191W DUG3 hom Verified 0.569620489568278 0.284467564179134 no 1380 0.274788499893136 940 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Component of glutamine amidotransferase (GATase II); forms a complex with Dug2p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p) glutathione catabolic process peptidase activity|omega peptidase activity|gamma-glutamyltransferase activity|carbon-nitrogen ligase activity, with glutamine as amido-N-donor cytoplasm
YLR315W YLR315W NKP2 hom Verified 0.566764055076103 0.285437247410366 no 1381 0.330874312527401 1119 NA FT CELL CYCLE|CELL DIVISION NUCLEUS|CHROMOSOME|CYTOSKELETON KINETOCHORE Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2 biological_process molecular_function spindle pole body|kinetochore
YGL139W YGL139W FLC3 hom Verified 0.566060843631541 0.28567621012705 no 1382 0.272609366844954 934 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER FAD transport|transmembrane transport FAD transmembrane transporter activity mitochondrion|integral to membrane|endoplasmic reticulum
YGL088W_d YGL088W YGL088W hom Dubious 0.566056696857199 0.285677619550846 no 1383 0.283633830125247 969 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps snR10, a snoRNA required for preRNA processing Unknown Unknown Unknown
YER044C YER044C ERG28 hom Verified 0.565935175115395 0.285718924360854 no 1384 0.295301449173896 1022 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Endoplasmic reticulum membrane protein, may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER, also interacts with Erg6p ergosterol biosynthetic process protein binding, bridging endoplasmic reticulum membrane
YGR021W_p YGR021W YGR021W hom Uncharacterized 0.565428933588716 0.285891024626553 no 1385 0.29528349355369 1019 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YDR522C YDR522C SPS2 hom Verified 0.565204135015471 0.285967462235948 no 1386 0.264637321980241 923 NA FT CELL CYCLE|CELL WALL ORG/BIOGENESIS PLASMA MEMBRANE Protein expressed during sporulation; SPS2 has a paralog, SPS22, that arose from the whole genome duplication; redundant with Sps22p for organization of the beta-glucan layer of the spore wall; S. pombe ortholog is a spore wall component ascospore wall assembly|ascospore formation molecular_function fungal-type cell wall|plasma membrane
YPL187W YPL187W MF(ALPHA)1 hom Verified 0.564115052351506 0.286337917329705 no 1387 0.289457813013295 963 NA FT SIGNALING Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)2, although MF(ALPHA)1 produces most alpha-factor pheromone-dependent signal transduction involved in conjugation with cellular fusion mating pheromone activity extracellular region
YOR179C YOR179C SYC1 hom Verified 0.563975625573678 0.286385360257445 no 1388 0.28455994028487 984 NA FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS Subunit of the APT subcomplex of cleavage and polyadenylation factor; may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAs; SYC1 has a paralog, YSH1, that arose from the whole genome duplication termination of RNA polymerase II transcription, exosome-dependent|termination of RNA polymerase II transcription, poly(A)-coupled RNA binding mRNA cleavage and polyadenylation specificity factor complex|nucleus
YLL028W YLL028W TPO1 hom Verified 0.563089268035105 0.286687049487129 no 1389 0.239721117827506 795 NA FT PLASMA MEMBRANE Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane spermidine transport|putrescine transport|spermine transport spermidine transmembrane transporter activity|spermine transmembrane transporter activity fungal-type vacuole membrane|integral to membrane|cellular bud membrane|plasma membrane
YHR049C-A_d YHR049C-A YHR049C-A hom Dubious 0.562628283005532 0.286844014358144 no 1390 0.270441969813119 918 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YMR165C YMR165C PAH1 hom Verified 0.562324031511108 0.286947633947054 no 1391 0.288096637377622 984 NA FT LIPID METABOLISM|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Mg2+-dependent phosphatidate (PA) phosphatase; dephosphorylates PA to yield diacylglycerol; responsible for de novo lipid synthesis and formation of lipid droplets; phosphorylation by Pho80p-Pho85p decreases catalytic activity and alters Pah1p localization and abundance; phosphorylation by protein kinase A decreases catalytic efficiency; dephosphorylation by Nem1p-Spo7p anchors Pah1p to the membrane increasing substrate catalysis; homologous to mammalian lipins 1 and 2 plasmid maintenance|vacuole fusion, non-autophagic|lipid particle organization|aerobic respiration|phospholipid biosynthetic process phosphatidate phosphatase activity cytosol|nuclear membrane|vacuole|cytoplasm|extrinsic to membrane
YLR146C YLR146C SPE4 hom Verified 0.559673068730217 0.287851227587054 no 1392 0.27763742865863 955 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM Spermine synthase, required for the biosynthesis of spermine and also involved in biosynthesis of pantothenic acid pantothenate biosynthetic process|spermine biosynthetic process spermine synthase activity cytoplasm
YPL009C YPL009C TAE2 hom Verified 0.559434481472243 0.287932617093927 no 1393 0.287641556505277 994 NA FT TRANSLATION Protein of unknown function, involved in protein translation; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm cytoplasmic translation molecular_function ribosome|cytoplasm
YML050W YML050W AIM32 hom Verified 0.558886384359051 0.288119631144058 no 1394 0.306027335801638 1037 NA Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss biological_process molecular_function cellular_component
YBL013W YBL013W FMT1 hom Verified 0.55846534201739 0.288263332252164 no 1395 0.321020024219798 1082 NA FT KETONE METABOLISM|RNA PROCESSING|AMINO ACID METABOLISM|TRANSLATION MITOCHONDRION Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate translational initiation|methionyl-tRNA aminoacylation methionyl-tRNA formyltransferase activity mitochondrion
YMR326C_d YMR326C YMR326C hom Dubious 0.557682973948875 0.288530443003657 no 1396 0.280941281800356 953 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the telomere on the right arm of chromosome 13 Unknown Unknown Unknown
YDR231C YDR231C COX20 hom Verified 0.557023448588191 0.288755704194937 no 1397 0.290624816656385 983 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase mitochondrial respiratory chain complex IV assembly|protein processing|aerobic respiration unfolded protein binding mitochondrion|mitochondrial inner membrane
YMR038C YMR038C CCS1 hom Verified 0.556064791490387 0.289083281544901 no 1398 0.353813102829882 1187 NA FF|FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS NUCLEUS|MITOCHONDRION Copper chaperone for superoxide dismutase Sod1p; involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation; protein abundance increases in response to DNA replication stress intracellular copper ion transport superoxide dismutase copper chaperone activity cytosol|mitochondrial inner membrane|nucleus
YNR060W YNR060W FRE4 hom Verified 0.554703130536502 0.289548867282888 no 1399 0.283130133713416 974 NA FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY PLASMA MEMBRANE Ferric reductase, reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels siderophore transport ferric-chelate reductase activity integral to membrane|plasma membrane
YJR097W YJR097W JJJ3 hom Verified 0.553819017439419 0.289851355936333 no 1400 0.298524099520404 1024 NA FT NUCLEUS Protein of unknown function, contains a CSL Zn finger and a DnaJ-domain; involved in diphthamide biosynthesis; ortholog human Dph4 peptidyl-diphthamide biosynthetic process from peptidyl-histidine ferrous iron binding nucleus|cytoplasm
YKL147C_d YKL147C YKL147C hom Dubious 0.552971460170125 0.290141476540285 no 1401 0.245454334844137 817 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene AVT3 Unknown Unknown Unknown
YOR234C YOR234C RPL33B hom Verified 0.552221840941124 0.290398186093937 no 1402 0.285115033577811 969 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L33B; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33B has a paralog, RPL33A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YGR110W YGR110W CLD1 hom Verified 0.551999155400645 0.290474465966354 no 1403 0.30396560374192 1040 NA FT LIPID METABOLISM MITOCHONDRION Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58 cardiolipin acyl-chain remodeling|cardiolipin metabolic process phospholipase A2 activity mitochondrion
YDR281C YDR281C PHM6 hom Verified 0.551907310010866 0.290505929899126 no 1404 0.307461076573046 1069 NA Protein of unknown function, expression is regulated by phosphate levels biological_process molecular_function fungal-type vacuole
YAL012W YAL012W CYS3 hom Verified 0.549981626739373 0.291165987817012 no 1405 0.313295287961737 1067 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM Cystathionine gamma-lyase, catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine; protein abundance increases in response to DNA replication stress sulfur amino acid metabolic process|cysteine biosynthetic process|cysteine biosynthetic process via cystathionine|transsulfuration|cysteine metabolic process cystathionine gamma-lyase activity cytoplasm
YOL129W YOL129W VPS68 hom Verified 0.547399258540361 0.292052232284446 no 1406 0.30163417330293 1041 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT MITOCHONDRION Vacuolar membrane protein of unknown function involved in vacuolar protein sorting; also detected in the mitochondria late endosome to vacuole transport via multivesicular body sorting pathway|protein targeting to vacuole molecular_function Vps55/Vps68 complex|mitochondrion|fungal-type vacuole membrane|integral to membrane
YJR108W YJR108W ABM1 hom Verified 0.547389106957737 0.292055718688639 no 1407 0.277515019192919 945 NA FT CYTOSKELETON ORGANIZATION Protein of unknown function, required for normal microtubule organization microtubule cytoskeleton organization molecular_function cellular_component
YIL124W YIL124W AYR1 hom Verified 0.547215050343719 0.292115498756825 no 1408 0.293256252700113 989 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS ENDOPLASMIC RETICULUM|MITOCHONDRION NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase found in lipid particles, ER, and mitochondrial outer membrane; involved in phosphatidic acid biosynthesis; required for spore germination; capable of metabolizing steroid hormones phosphatidic acid biosynthetic process acylglycerone-phosphate reductase activity mitochondrial outer membrane|mitochondrion|integral to membrane|endoplasmic reticulum|lipid particle|cytoplasm
YOL044W YOL044W PEX15 hom Verified 0.547090625807581 0.292158236085618 no 1409 0.278783950309209 936 NA FT PROTEIN LOCALIZATION|SIGNALING|PEROXISOME ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Phosphorylated tail-anchored type II integral peroxisomal membrane protein required for peroxisome biogenesis, cells lacking Pex15p mislocalize peroxisomal matrix proteins to cytosol, overexpression results in impaired peroxisome assembly protein import into peroxisome matrix, receptor recycling protein anchor integral to peroxisomal membrane
YDR135C YDR135C YCF1 hom Verified 0.546498503922428 0.292361657916823 no 1410 0.268620472268767 926 NA FT NUCLEOTIDE METABOLISM Vacuolar glutathione S-conjugate transporter; member of the ATP-binding cassette family; has a role in detoxifying metals such as cadmium, mercury, and arsenite; also transports unconjugated bilirubin, selenodigluthatione, and oxidized glutathione; similar to human cystic fibrosis protein CFTR bilirubin transport|response to metal ion|transmembrane transport bilirubin transmembrane transporter activity|glutathione S-conjugate-exporting ATPase activity fungal-type vacuole membrane|integral to membrane
YHR100C YHR100C GEP4 hom Verified 0.546293747953927 0.292432016583864 no 1411 0.347594428525052 1162 NA FF|FT LIPID METABOLISM|CARBOHYDRATE METABOLISM MITOCHONDRION Mitochondrial phosphatidylglycerophosphatase (PGP phosphatase), dephosphorylates phosphatidylglycerolphosphate to generate phosphatidylglycerol, an essential step during cardiolipin biosynthesis; null mutant is sensitive to tunicamycin, DTT cardiolipin biosynthetic process|phosphorylated carbohydrate dephosphorylation phosphatidylglycerophosphatase activity mitochondrion|mitochondrial matrix
YDR046C YDR046C BAP3 hom Verified 0.545356662863273 0.292754120093888 no 1412 0.271533114084662 926 NA FT MITOCHONDRION|PLASMA MEMBRANE Amino acid permease; involved in uptake of cysteine, leucine, isoleucine and valine; BAP3 has a paralog, BAP2, that arose from the whole genome duplication amino acid transport|transmembrane transport amino acid transmembrane transporter activity mitochondrion|integral to membrane|plasma membrane
YIL116W YIL116W HIS5 hom Verified 0.545322740010229 0.292765783458391 no 1413 0.293562555734462 1017 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Histidinol-phosphate aminotransferase, catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts histidine biosynthetic process histidinol-phosphate transaminase activity intracellular
YKL105C YKL105C SEG2 hom Verified 0.543188842124955 0.293499894081252 no 1414 0.280423920345324 954 NA Eisosome component and paralog of Seg1p; likely plays only minor role in eisosome assembly; shown to interact with Seg1p; similar to A. gossypii SEG gene which is important for stabilizing eisosomes biological_process molecular_function cellular_component
YFL011W YFL011W HXT10 hom Verified 0.541329531263988 0.294140234568062 no 1415 0.319951687597789 1098 NA FT MITOCHONDRION|PLASMA MEMBRANE Putative hexose transporter, expressed at low levels and expression is repressed by glucose hexose transport|transmembrane transport galactose transmembrane transporter activity|mannose transmembrane transporter activity|fructose transmembrane transporter activity|glucose transmembrane transporter activity mitochondrion|integral to membrane|plasma membrane
YNR073C_p YNR073C YNR073C hom Uncharacterized 0.539900375061367 0.294632869611929 no 1416 0.331459351366652 1107 NA Putative mannitol dehydrogenase; identical in amino acid sequence to Dsf1p biological_process mannitol dehydrogenase activity cellular_component
YCL040W YCL040W GLK1 hom Verified 0.537557877296171 0.295441158742117 no 1417 0.301189741892123 1022 NA FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Glucokinase; catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources; GLK1 has a paralog, EMI2, that arose from the whole genome duplication glucose import|mannose metabolic process|glycolysis|glucose metabolic process glucokinase activity cytosol|plasma membrane
YKL067W YKL067W YNK1 hom Verified 0.537462996808633 0.295473919153136 no 1418 0.267757130966824 896 NA FT RESPONSE TO DNA DAMAGE|NUCLEOTIDE METABOLISM MITOCHONDRION Nucleoside diphosphate kinase; catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate; protein abundance increases in response to DNA replication stress nucleoside diphosphate phosphorylation|nucleoside triphosphate biosynthetic process|response to DNA damage stimulus nucleoside diphosphate kinase activity cytosol|mitochondrion|mitochondrial intermembrane space
YLR376C YLR376C PSY3 hom Verified 0.537366177250667 0.295507350810165 no 1419 0.287482808497933 1001 NA FT RESPONSE TO DNA DAMAGE NUCLEUS Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function; structural analysis reveals a similar DNA-binding region in both Psy3p and Csm2p and that both regions work together to form a single DNA binding site; deletion of PSY3 results in a mutator phenotype; deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C recombinational repair|error-free translesion synthesis molecular_function nucleus|Shu complex|cytoplasm
YDR181C YDR181C SAS4 hom Verified 0.536539217597551 0.295792969667015 no 1420 0.336885237091989 1142 NA FT CHROMATIN ORGANIZATION|PROTEOLYSIS|GENE SILENCING NUCLEUS|CHROMOSOME HISTONE ACETYLTRANSFERASE Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p chromatin silencing at telomere acetyltransferase activity|histone acetyltransferase activity nuclear chromatin|SAS acetyltransferase complex|nuclear chromosome, telomeric region
YKR045C_p YKR045C YKR045C hom Uncharacterized 0.536290910650624 0.295878755731485 no 1421 0.296756404383252 999 NA Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm biological_process molecular_function cytoplasm
YBL080C YBL080C PET112 hom Verified 0.536254254804 0.295891420705944 no 1422 0.321234811217924 1096 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; mutation is functionally complemented by the bacterial GatB ortholog glutaminyl-tRNAGln biosynthesis via transamidation|mitochondrial translation glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity mitochondrion|glutamyl-tRNA(Gln) amidotransferase complex
YOR299W YOR299W BUD7 hom Verified 0.53582289172828 0.296040479813725 no 1423 0.292956949549358 987 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM GOLGI APPARATUS Member of the ChAPs family (Chs5p-Arf1p-binding proteins); members include Bch1p, Bch2p, Bud7p, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; BUD7 has a paralog, BCH1, that arose from the whole genome duplication Golgi to plasma membrane transport|fungal-type cell wall chitin biosynthetic process|cellular bud site selection molecular_function trans-Golgi network transport vesicle|clathrin-coated vesicle|exomer complex
YDL119C_p YDL119C YDL119C hom Uncharacterized 0.533430366678274 0.296867850705974 no 1424 0.302696782808887 1048 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Putative mitochondrial transport protein; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in purified mitochondria transport transporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YKL001C YKL001C MET14 hom Verified 0.5329554495627 0.297032209928996 no 1425 0.28124653334258 971 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)|sulfur amino acid metabolic process adenylylsulfate kinase activity cytoplasm
YKR058W YKR058W GLG1 hom Verified 0.532152630893022 0.297310143857177 no 1426 0.28744975693629 1010 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG1 has a paralog, GLG2, that arose from the whole genome duplication glycogen biosynthetic process glycogenin glucosyltransferase activity cellular_component
YOR019W YOR019W YOR019W hom Verified 0.53189546444775 0.297399199394805 no 1427 0.291682645964946 990 NA FT CELL CYCLE Protein of unknown function that may interact with ribosomes, based on co-purification experiments mitochondrion degradation molecular_function ribosome
YIL087C YIL087C AIM19 hom Verified 0.530005353234319 0.298054109603966 no 1428 0.287392260224243 976 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth biological_process molecular_function mitochondrion
YDR004W YDR004W RAD57 hom Verified 0.529372651587589 0.298273482984938 no 1429 0.310432566855506 1083 NA FF|FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p DNA recombinase assembly|telomere maintenance via recombination|heteroduplex formation|meiotic DNA recombinase assembly|double-strand break repair via single-strand annealing DNA-dependent ATPase activity|protein heterodimerization activity nucleus|Rhp55-Rhp57 complex
YOL013C YOL013C HRD1 hom Verified 0.526571862106504 0.299245468102319 no 1430 0.282346850848088 971 NA FT CELL WALL ORG/BIOGENESIS|PROTEOLYSIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM UBIQUITIN LIGASE COMPLEX Ubiquitin-protein ligase; required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; likely plays a general role in targeting proteins that persistently associate with and potentially obstruct the ER-localized translocon fungal-type cell wall organization|ER-associated protein catabolic process ubiquitin-protein ligase activity Hrd1p ubiquitin ligase ERAD-M complex|integral to membrane|Hrd1p ubiquitin ligase ERAD-L complex|endoplasmic reticulum membrane
YJR118C YJR118C ILM1 hom Verified 0.526329652413185 0.299329591952291 no 1431 0.326864397717846 1086 NA FF|FT MITOCHONDRION ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth mitochondrial genome maintenance molecular_function integral to membrane|endoplasmic reticulum
YAL051W YAL051W OAF1 hom Verified 0.525660896742264 0.299561918686253 no 1432 0.291746108585197 946 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GENE SILENCING NUCLEUS Oleate-activated transcription factor; acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis; OAF1 has a paralog, PIP2, that arose from the whole genome duplication cellular response to oleic acid|positive regulation of fatty acid beta-oxidation|positive regulation of chromatin silencing at telomere|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YNL100W YNL100W AIM37 hom Verified 0.524491325778699 0.299968425717931 no 1433 0.325090318847846 1110 NA FT MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial inner membrane protein; component of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture cristae formation molecular_function mitochondrion|mitochondrial crista junction|integral to mitochondrial inner membrane
YBL091C-A YBL091C-A SCS22 hom Verified 0.523641476829345 0.300263963673999 no 1434 0.30135485533916 1039 NA FT LIPID METABOLISM Protein involved in regulation of phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; similar to D. melanogaster inturned protein; SCS22 has a paralog, SCS2, that arose from the whole genome duplication phospholipid biosynthetic process|chromatin silencing at telomere molecular_function cellular_component
YPR185W YPR185W ATG13 hom Verified 0.523176290264206 0.30042578965573 no 1435 0.291466092791048 973 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Regulatory subunit of the Atg1p signaling complex; stimulates Atg1p kinase activity; required for vesicle formation during autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; involved in Atg9p, Atg23p, and Atg27p cycling piecemeal microautophagy of nucleus|mitochondrion degradation|macroautophagy|activation of protein kinase activity|CVT pathway protein kinase regulator activity Atg1p signaling complex|extrinsic to membrane
YKL106W YKL106W AAT1 hom Verified 0.522091096802299 0.300803452555548 no 1436 0.285516820300297 985 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis aspartate catabolic process|chronological cell aging|replicative cell aging|asparagine biosynthetic process from oxaloacetate|aspartate biosynthetic process L-aspartate:2-oxoglutarate aminotransferase activity mitochondrion
YMR023C YMR023C MSS1 hom Verified 0.520793422896581 0.301255342668786 no 1437 0.270072510953267 902 NA FT RNA PROCESSING|SIGNALING|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial protein, forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; similar to human GTPBP3 mitochondrial tRNA wobble uridine modification|Unknown GTP binding mitochondrion|mitochondrial inner membrane
YGR035C_p YGR035C YGR035C hom Uncharacterized 0.520440111541608 0.301378429524163 no 1438 0.285199086923436 963 NA Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance biological_process molecular_function cellular_component
YCL044C YCL044C MGR1 hom Verified 0.517621801225239 0.302361083906861 no 1439 0.29306740028337 1000 NA FT PROTEOLYSIS MITOCHONDRION Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr3p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA misfolded or incompletely synthesized protein catabolic process misfolded protein binding mitochondrion|i-AAA complex
YJR077C YJR077C MIR1 hom Verified 0.515665835678082 0.303043909975267 no 1440 0.294769847889578 1018 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated phosphate ion transmembrane transport inorganic phosphate transmembrane transporter activity mitochondrion|integral to membrane|integral to mitochondrial inner membrane
YJR139C YJR139C HOM6 hom Verified 0.513096051844267 0.303942066583493 no 1441 0.319663017215205 1108 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS NUCLEUS Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions threonine biosynthetic process|methionine biosynthetic process|homoserine biosynthetic process homoserine dehydrogenase activity nucleus|cytoplasm
YHR043C YHR043C DOG2 hom Verified 0.51301973833776 0.303968756803483 no 1442 0.296696863979616 1018 NA FT CARBOHYDRATE METABOLISM NUCLEUS 2-deoxyglucose-6-phosphate phosphatase; member of a family of low molecular weight phosphatases, paralogous to DOG1, induced by oxidative and osmotic stress, confers 2-deoxyglucose resistance when overexpressed glucose metabolic process 2-deoxyglucose-6-phosphatase activity nucleus|cytoplasm
YMR152W YMR152W YIM1 hom Verified 0.5125507066585 0.304132820940443 no 1443 0.29521557522527 1021 NA FT RESPONSE TO DNA DAMAGE|OXIDATION-REDUCTION PROCESS MITOCHONDRION Protein of unknown function; null mutant displays sensitivity to DNA damaging agents; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress response to DNA damage stimulus molecular_function mitochondrion|lipid particle|cytoplasm
YOR368W YOR368W RAD17 hom Verified 0.510149634848445 0.304973317025526 no 1444 0.308126416233698 1042 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins double-strand break repair|reciprocal meiotic recombination|DNA damage checkpoint double-stranded DNA binding nucleus|checkpoint clamp complex
YNL053W YNL053W MSG5 hom Verified 0.508454835002056 0.305567202753094 no 1445 0.314747048226652 1083 NA FT PROTEIN LOCALIZATION|CELL CYCLE|SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION NUCLEUS Dual-specificity protein phosphatase; exists in 2 isoforms; required for maintenance of a low level of signaling through the cell integrity pathway, adaptive response to pheromone; regulates and is regulated by Slt2p; dephosphorylates Fus3p adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|regulation of fungal-type cell wall organization|inactivation of MAPK activity involved in cell wall biogenesis|regulation of MAPK export from nucleus|protein dephosphorylation|inactivation of MAPK activity involved in conjugation with cellular fusion protein tyrosine/serine/threonine phosphatase activity nucleus|cytoplasm
YGL185C_p YGL185C YGL185C hom Uncharacterized 0.507119698236789 0.306035417227265 no 1446 0.345721507104337 1158 NA FT OXIDATION-REDUCTION PROCESS Putative protein with sequence similarity to hydroxyacid dehydrogenases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm metabolic process oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor cytoplasm
YKR034W YKR034W DAL80 hom Verified 0.506827703442745 0.306137858150217 no 1447 0.302424397968556 1039 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS NUCLEUS Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Gzf3p; DAL80 has a paralog, GZF3, that arose from the whole genome duplication nitrogen catabolite repression of transcription|negative regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity nucleus
YLR421C YLR421C RPN13 hom Verified 0.504641095692703 0.30690547009591 no 1448 0.315382119404936 1090 NA FT PROTEOLYSIS NUCLEUS Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; protein abundance increases in response to DNA replication stress ubiquitin-dependent protein catabolic process ubiquitin binding proteasome storage granule|proteasome regulatory particle, lid subcomplex
YOR154W_p YOR154W SLP1 hom Uncharacterized 0.504219956147434 0.307053409184246 no 1449 0.279369240341045 964 NA Glycosylated integral ER membrane protein of unknown function; forms an ER-membrane associated protein complex with Emp65p; member of the SUN-like family of proteins; genetic interactions suggest a role in folding of ER membrane proteins; required for nuclear envelope localization of Mps3p protein folding in endoplasmic reticulum molecular_function cellular_component
YNL179C_d YNL179C YNL179C hom Dubious 0.504211516825571 0.307056374094222 no 1450 0.306580996589332 1075 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance Unknown Unknown Unknown
YJR147W YJR147W HMS2 hom Verified 0.504133925726223 0.307083634058659 no 1451 0.290977443366512 964 NA FT NUCLEUS Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant; HMS2 has a paralog, SKN7, that arose from the whole genome duplication pseudohyphal growth molecular_function nucleus|cytoplasm
YGL138C_p YGL138C YGL138C hom Uncharacterized 0.503849328349232 0.307183630355464 no 1452 0.30669078798402 1039 NA Putative protein of unknown function; has no significant sequence similarity to any known protein biological_process molecular_function cellular_component
YER134C YER134C YER134C hom Verified 0.501977860250837 0.307841547364507 no 1453 0.306712094416037 1050 NA FT NUCLEUS Magnesium-dependent acid phosphatase, member of the haloacid dehalogenase superfamily; non-essential gene biological_process acid phosphatase activity nucleus|cytoplasm
YPL157W YPL157W TGS1 hom Verified 0.500031956856449 0.308526287914766 no 1454 0.289069385076685 987 NA FT CELL CYCLE|RNA PROCESSING NUCLEUS Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs meiosis|RNA methylation|nucleologenesis|7-methylguanosine cap hypermethylation|regulation of telomere maintenance via telomerase RNA methyltransferase activity nucleolus
YDR295C YDR295C HDA2 hom Verified 0.49961257346966 0.30867395138262 no 1455 0.287488304938464 972 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex containing an Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance negative regulation of transcription from RNA polymerase II promoter|gene silencing by RNA|histone deacetylation|gene silencing involved in chronological cell aging histone deacetylase activity|chromatin binding|DNA binding nucleus|HDA1 complex
YML060W YML060W OGG1 hom Verified 0.499377934908346 0.30875658032439 no 1456 0.306719758148502 1030 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA, contributes to UVA resistance DNA repair|base-excision repair, AP site formation oxidized purine nucleobase lesion DNA N-glycosylase activity mitochondrion
YOR078W YOR078W BUD21 hom Verified 0.496921185373776 0.309622315632819 no 1457 0.300150024527496 999 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA; originally isolated as bud-site selection mutant that displays a random budding pattern endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) snoRNA binding small-subunit processome|nucleolus|90S preribosome
YIL074C YIL074C SER33 hom Verified 0.495297356235353 0.310195118421725 no 1458 0.297523317597431 1035 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS 3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER33 has a paralog, SER3, that arose from the whole genome duplication serine family amino acid biosynthetic process phosphoglycerate dehydrogenase activity cytoplasm
YDR070C YDR070C FMP16 hom Verified 0.495282740440655 0.310200276211365 no 1459 0.297851098869697 999 NA FT MITOCHONDRION Protein of unknown function; may be involved in responding to conditions of stress; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress biological_process molecular_function mitochondrion
YLR398C YLR398C SKI2 hom Verified 0.495016967192051 0.310294071841895 no 1460 0.313986010543525 1082 NA FT TRANSLATION Ski complex component and putative RNA helicase, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, non-stop decay RNA helicase activity Ski complex
YMR287C YMR287C DSS1 hom Verified 0.494675323122423 0.310414661626083 no 1461 0.324283303257757 1066 NA FT MITOCHONDRION 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs mitochondrial RNA catabolic process exoribonuclease II activity mitochondrion|mitochondrial degradosome
YOL073C YOL073C YOL073C hom Verified 0.494336044511707 0.310534436647055 no 1462 0.309628089763997 1049 NA Subunit of the DSC ubiquitin ligase complex; ortholog of fission yeast dsc2 biological_process molecular_function integral to membrane
YJL192C YJL192C SOP4 hom Verified 0.492017651698357 0.311353432538497 no 1463 0.381702574470386 1281 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM ER-membrane protein; suppressor of pma1-7, deletion of SOP4 slows down the export of wild-type Pma1p and Pma1-7 from the ER ER to Golgi vesicle-mediated transport molecular_function integral to membrane|endoplasmic reticulum
YKR046C YKR046C PET10 hom Verified 0.491288539763368 0.311611192129551 no 1464 0.307123093670099 1040 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY Protein of unknown function that co-purifies with lipid particles; expression pattern suggests a role in respiratory growth; computational analysis of large-scale protein-protein interaction data suggests a role in ATP/ADP exchange aerobic respiration molecular_function lipid particle
YJL191W YJL191W RPS14B hom Verified 0.490306735854156 0.311958430634838 no 1465 0.323443974473711 1092 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION NUCLEUS RIBOSOME Protein component of the small (40S) ribosomal subunit; required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; homologous to mammalian ribosomal protein S14 and bacterial S11; RPS14B has a paralog, RPS14A, that arose from the whole genome duplication cytoplasmic translation|ribosomal small subunit assembly|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome|SSU rRNA binding small-subunit processome|cytosolic small ribosomal subunit
YFL042C_p YFL042C YFL042C hom Uncharacterized 0.489769414797375 0.312148537922933 no 1466 0.317696041033978 1063 NA Putative protein of unknown function; YFL042C is not an essential gene biological_process molecular_function cellular_component
YDR506C YDR506C GMC1 hom Verified 0.489059700899233 0.312399715476701 no 1467 0.299952746674882 1004 NA FT CELL CYCLE|ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS Protein involved in meiotic progression; mutants are delayed in meiotic nuclear division and are defective in synaptonemal complex assembly; possible membrane-localized protein meiosis|synaptonemal complex organization molecular_function cellular_component
YDR333C YDR333C RQC1 hom Verified 0.488051404337555 0.312756715477466 no 1468 0.298092101931946 996 NA Component of the ribosome quality control complex (RQC); RQC (Rqc1p-Ltn1p-Tae2p-Cdc48p-Npl4p-Ufd1p), is a ribosome-bound complex required for the degradation of polypeptides arising from stalled translation; required along with Ltn1p for recruitment of the Cdc48p-Npl4p-Ufd1p AAA ATPase complex to the RQC biological_process molecular_function cytoplasm
YDR033W YDR033W MRH1 hom Verified 0.485396927432677 0.313697405739924 no 1469 0.314040217936808 1064 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION|PLASMA MEMBRANE Protein that localizes primarily to the plasma membrane; also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; MRH1 has a paralog, YRO2, that arose from the whole genome duplication biological_process molecular_function mitochondrion|integral to membrane|plasma membrane
YGR230W YGR230W BNS1 hom Verified 0.485189029829213 0.313771131517034 no 1470 0.304317461161581 1036 NA FT CELL CYCLE Protein with some similarity to Spo12p; overexpression bypasses need for Spo12p, but not required for meiosis meiosis molecular_function cellular_component
YGL107C YGL107C RMD9 hom Verified 0.485123046708101 0.313794532364648 no 1471 0.324298232189601 1084 NA FT TRANSLATION|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes translational initiation|regulation of mRNA stability|aerobic respiration molecular_function extrinsic to mitochondrial inner membrane|mitochondrion
YPR095C YPR095C SYT1 hom Verified 0.484951236224474 0.313855468294477 no 1472 0.322705444926627 1112 NA FT VESICLE-MEDIATED TRANSPORT|SIGNALING MITOCHONDRION|GOLGI APPARATUS Guanine nucleotide exchange factor (GEF) for Arf proteins; promotes activation of Arl1p, which recruits Imh1p to the Golgi; involved in vesicular transport; member of the Sec7-domain family; contains a PH domain vesicle-mediated transport|exocytosis|positive regulation of ARF protein signal transduction ARF guanyl-nucleotide exchange factor activity mitochondrion|Golgi apparatus part
YLR219W YLR219W MSC3 hom Verified 0.484839496599255 0.313895101650923 no 1473 0.279018920741192 958 NA FT CELL CYCLE PLASMA MEMBRANE Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; msc3 mutants are defective in directing meiotic recombination events to homologous chromatids; potential Cdc28p substrate; protein abundance increases in response to DNA replication stress reciprocal meiotic recombination molecular_function cellular_component
YOR118W YOR118W RTC5 hom Verified 0.48436835504422 0.314062236266264 no 1474 0.334264910091507 1138 NA Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity biological_process molecular_function cytoplasm
YMR286W YMR286W MRPL33 hom Verified 0.484044071751355 0.314177295966869 no 1475 0.308335963105151 1066 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YKL214C YKL214C YRA2 hom Verified 0.48401639687031 0.314187116191659 no 1476 0.296755948979494 1014 NA FT RNA LOCALIZATION NUCLEUS Member of the REF (RNA and export factor binding proteins) family; when overexpressed, can substitute for the function of Yra1p in export of poly(A)+ mRNA from the nucleus poly(A)+ mRNA export from nucleus RNA binding nucleus
YKL120W YKL120W OAC1 hom Verified 0.481154431812345 0.315203372242579 no 1477 0.309115287248896 1053 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Mitochondrial inner membrane transporter, transports oxaloacetate, sulfate, thiosulfate, and isopropylmalate; member of the mitochondrial carrier family sulfate transport|oxaloacetate transport|isopropylmalate transport secondary active sulfate transmembrane transporter activity|oxaloacetate secondary active transmembrane transporter activity|isopropylmalate transmembrane transporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YNR033W YNR033W ABZ1 hom Verified 0.480107918095026 0.315575329116838 no 1478 0.295107452249907 972 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress para-aminobenzoic acid biosynthetic process 4-amino-4-deoxychorismate synthase activity cytoplasm
YDL231C YDL231C BRE4 hom Verified 0.478150395040808 0.316271582865028 no 1479 0.322858496535338 1081 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION Zinc finger protein containing five transmembrane domains; null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect intracellular transport endocytosis molecular_function integral to membrane
YJL084C YJL084C ALY2 hom Verified 0.477535525723142 0.316490414853809 no 1480 0.298949186340563 1043 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION Alpha arrestin that controls nutrient-mediated intracellular sorting of permease Gap1p; interacts with AP-1 subunit Apl4p; phosphorylated by Npr1p and also by cyclin-CDK complex Pcl7p-Pho85p; promotes endocytosis of plasma membrane proteins; ALY2 has a paralog, ALY1, that arose from the whole genome duplication Unknown|regulation of intracellular transport|ubiquitin-dependent endocytosis protein binding, bridging|ubiquitin protein ligase binding late endosome|cytoplasm|early endosome
YLR061W YLR061W RPL22A hom Verified 0.47735122966444 0.316556018341166 no 1481 0.311193173746732 1047 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YPL038W-A_p YPL038W-A YPL038W-A hom Uncharacterized 0.476675550710096 0.316796587739989 no 1482 0.298750200657282 1005 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YER131W YER131W RPS26B hom Verified 0.476394119903134 0.316896811506954 no 1483 0.317967312461105 1051 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S26, no bacterial homolog; RPS26B has a paralog, RPS26A, that arose from the whole genome duplication cytoplasmic translation|rRNA export from nucleus structural constituent of ribosome cytosolic small ribosomal subunit
YCR095C_p YCR095C OCA4 hom Uncharacterized 0.476242657797478 0.316950756092618 no 1484 0.308655153664753 1051 NA Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts biological_process molecular_function cytoplasm
YJR024C YJR024C MDE1 hom Verified 0.476005907169501 0.317035084744172 no 1485 0.305087212173419 1015 NA FT KETONE METABOLISM|AMINO ACID METABOLISM 5'-methylthioribulose-1-phosphate dehydratase; acts in the methionine salvage pathway; potential Smt3p sumoylation substrate; expression downregulated by caspofungin and deletion mutant is caspofungin resistant L-methionine salvage from methylthioadenosine methylthioribulose 1-phosphate dehydratase activity cytoplasm
YGL208W YGL208W SIP2 hom Verified 0.475360100288176 0.317265164222483 no 1486 0.302857361997151 1062 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|SIGNALING|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS PLASMA MEMBRANE One of three beta subunits of the Snf1 serine/threonine protein kinase complex involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and the plasma membrane cellular response to glucose starvation|signal transduction|protein phosphorylation|replicative cell aging|invasive growth in response to glucose limitation|regulation of protein complex assembly AMP-activated protein kinase activity AMP-activated protein kinase complex|plasma membrane|cytoplasm
YDL133W YDL133W SRF1 hom Verified 0.474284088471796 0.317648668257075 no 1487 0.37543551361473 1248 NA Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients positive regulation of catalytic activity molecular_function integral to membrane
YDR146C YDR146C SWI5 hom Verified 0.474113943611018 0.317709327942045 no 1488 0.304859965947224 1035 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE NUCLEUS Transcription factor that recruits Mediator and Swi/Snf complexes; activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; required for expression of the HO gene controlling mating type switching; localization to nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase; SWI5 has a paralog, ACE2, that arose from the whole genome duplication positive regulation of mating type switching|regulation of transcription involved in G1 phase of mitotic cell cycle|positive regulation of transcription on exit from mitosis, from RNA polymerase II promoter RNA polymerase II distal enhancer sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity|mediator complex binding nucleus|cytoplasm
YML079W_p YML079W YML079W hom Uncharacterized 0.47374260183056 0.317841734919 no 1489 0.321433763159535 1067 NA FT NUCLEUS Non-essential protein of unknown function with structural resemblance to plant storage and ligand binding proteins (canavalin, glycinin, auxin binding protein) and to some enzymes (epimerase, germin); localizes to the nucleus and cytoplasm biological_process molecular_function nucleus|cytoplasm
YBR242W_p YBR242W YBR242W hom Uncharacterized 0.472207688245025 0.318389276282741 no 1490 0.356480923159259 1165 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR242W is not an essential gene biological_process molecular_function nucleus|cytoplasm
YNL138W YNL138W SRV2 hom Verified 0.471538478405252 0.318628124200422 no 1491 0.390730723003252 1286 NA FT SIGNALING|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON CAP (cyclase-associated protein) subunit of adenylyl cyclase complex; N-terminus binds adenylyl cyclase and facilitates activation by RAS; C-terminus binds ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis cytoskeleton organization|Ras protein signal transduction cytoskeletal protein binding|adenylate cyclase binding mating projection tip|actin cortical patch
YER079W_p YER079W YER079W hom Uncharacterized 0.47099895020385 0.318820742289109 no 1492 0.309286348826929 1019 NA FT NUCLEUS Putative protein of unknown function biological_process molecular_function nucleus|cytoplasm
YBR131W YBR131W CCZ1 hom Verified 0.468447063659657 0.319732459247785 no 1493 0.320422468953567 1081 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Protein involved in vacuolar assembly, essential for autophagy and the cytoplasm-to-vacuole pathway autophagy|autophagic vacuole fusion|vacuolar transport|vesicle docking|protein targeting to vacuole guanyl-nucleotide exchange factor activity Mon1-Ccz1 complex|membrane
YMR095C YMR095C SNO1 hom Verified 0.468132122938248 0.319845054362333 no 1494 0.294841110492666 1000 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Protein of unconfirmed function, involved in pyridoxine metabolism; expression is induced during stationary phase; forms a putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminase pyridoxine metabolic process|thiamine biosynthetic process|anti-apoptosis molecular_function cytoplasm
YGR166W YGR166W TRS65 hom Verified 0.467796185329927 0.319965174416198 no 1495 0.354937433183149 1169 NA FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|CELL WALL ORG/BIOGENESIS GOLGI APPARATUS Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p; involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi; role in cell wall beta-glucan biosynthesis and the stress response intra-Golgi vesicle-mediated transport|protein complex assembly Rab guanyl-nucleotide exchange factor activity TRAPP complex|trans-Golgi network
YOR289W_p YOR289W YOR289W hom Uncharacterized 0.466298650117157 0.320500872428611 no 1496 0.31105271823099 1028 NA FT NUCLEUS Putative protein of unknown function; transcription induced by the unfolded protein response; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus biological_process molecular_function nucleus|cytoplasm
YJR090C YJR090C GRR1 hom Verified 0.465799059021094 0.320679669350498 no 1497 0.355638731223709 1190 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CARBOHYDRATE METABOLISM|PROTEOLYSIS NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON UBIQUITIN LIGASE COMPLEX F-box protein component of the SCF ubiquitin-ligase complex; involved in carbon catabolite repression, glucose-dependent divalent cation transport, high-affinity glucose transport, morphogenesis, and sulfite detoxification SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular response to methylmercury|cell cycle arrest in response to pheromone|G1/S transition of mitotic cell cycle|response to DNA damage stimulus|protein ubiquitination ubiquitin-protein ligase activity|protein binding, bridging cellular bud neck contractile ring|SCF ubiquitin ligase complex|nucleus|cytoplasm
YNL120C_d YNL120C YNL120C hom Dubious 0.465677993940516 0.320723003176708 no 1498 0.311015667513926 1067 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; deletion enhances replication of Brome mosaic virus in S. cerevisiae, but likely due to effects on the overlapping gene Unknown Unknown Unknown
YOR107W YOR107W RGS2 hom Verified 0.465505911776146 0.320784602174151 no 1499 0.33404006585173 1164 NA FT SIGNALING NUCLEUS|PLASMA MEMBRANE Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p adenylate cyclase-modulating G-protein coupled receptor signaling pathway GTPase activator activity nucleus|cytoplasm
YJR014W YJR014W TMA22 hom Verified 0.465423715582712 0.320814027087625 no 1500 0.267461797187829 883 NA FT TRANSLATION RIBOSOME Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1; protein abundance increases in response to DNA replication stress biological_process RNA binding ribosome|cytoplasm
YIL024C_p YIL024C YIL024C hom Uncharacterized 0.465405097033781 0.320820692384667 no 1501 0.316140382174202 1080 NA Putative protein of unknown function; non-essential gene; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p biological_process molecular_function cellular_component
YBR224W_d YBR224W YBR224W hom Dubious 0.46470439990527 0.321071578529146 no 1502 0.310458317687522 1027 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TDP1 Unknown Unknown Unknown
YPR158W YPR158W CUR1 hom Verified 0.462395488658961 0.321898866948056 no 1503 0.343088967299841 1159 NA FT NUCLEUS Sorting factor, central regulator of spatial protein quality control; physically and functionally interacts with chaperones to promote sorting and deposition of misfolded proteins into cytosolic compartments; involved in destabilization of [URE3] prions; CUR1 has a paralog, BTN2, that arose from the whole genome duplication cellular response to stress|protein localization to nucleus chaperone binding nucleus
YDL142C YDL142C CRD1 hom Verified 0.458797787910564 0.323189691718128 no 1504 0.319972948456871 1084 NA FT LIPID METABOLISM|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS MITOCHONDRION Cardiolipin synthase; produces cardiolipin, which is a phospholipid of the mitochondrial inner membrane that is required for normal mitochondrial membrane potential and function; also required for normal vacuolar ion homeostasis lipid biosynthetic process|cellular ion homeostasis|mitochondrial membrane organization cardiolipin synthase activity mitochondrion|integral to membrane
YGL016W YGL016W KAP122 hom Verified 0.457980461038878 0.323483239449046 no 1505 0.318217358746293 1076 NA FT PROTEIN LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE Karyopherin beta, responsible for import of the Toa1p-Toa2p complex into the nucleus; binds to nucleoporins Nup1p and Nup2p; may play a role in regulation of pleiotropic drug resistance protein import into nucleus|regulation of cell size protein transporter activity integral to membrane|nuclear pore|cytoplasm
YGL129C YGL129C RSM23 hom Verified 0.457832790989718 0.323536287738175 no 1506 0.321545634980809 1096 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit, has similarity to mammalian apoptosis mediator proteins; null mutation prevents induction of apoptosis by overproduction of metacaspase Mca1p mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YOR086C YOR086C TCB1 hom Verified 0.455439666055144 0.324396482000548 no 1507 0.298350582514423 1007 NA FT ENDOPLASMIC RETICULUM|MITOCHONDRION|PLASMA MEMBRANE Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains three calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact biological_process lipid binding mitochondrion|plasma membrane|cortical endoplasmic reticulum
YOR222W YOR222W ODC2 hom Verified 0.45518138843333 0.324489374479724 no 1508 0.309731560356087 1055 NA FT MITOCHONDRION Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism mitochondrial transport dicarboxylic acid transmembrane transporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YPR135W YPR135W CTF4 hom Verified 0.454043656301589 0.324898702709966 no 1509 0.394511173246566 1305 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Chromatin-associated protein, required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion DNA repair|replicative cell aging|double-strand break repair via break-induced replication|DNA replication initiation|DNA-dependent DNA replication|mitotic sister chromatid cohesion chromatin binding|DNA binding nuclear chromosome|replication fork protection complex|nuclear replication fork|nucleus
YKL046C YKL046C DCW1 hom Verified 0.453814480445719 0.324981180191412 no 1510 0.288259501621619 994 NA FT CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM PLASMA MEMBRANE Putative mannosidase, GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p fungal-type cell wall biogenesis|budding cell bud growth mannosidase activity anchored to plasma membrane
YPR039W_d YPR039W YPR039W hom Dubious 0.453025884566342 0.325265051362255 no 1511 0.342178993177279 1158 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified non essential genes ERV2/YPR037C and TIP41/YPR040W Unknown Unknown Unknown
YOL085C_d YOL085C YOL085C hom Dubious 0.451519218776447 0.325807688348794 no 1512 0.326627113402573 1096 NA Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A Unknown Unknown Unknown
YGL006W-A_p YGL006W-A YGL006W-A hom Uncharacterized 0.448623182285215 0.326851753841905 no 1513 0.30355608414682 1033 NA Putative protein of unknown function; identified by SAGE biological_process molecular_function cellular_component
YBR226C_d YBR226C YBR226C hom Dubious 0.448167356796425 0.327016209723501 no 1514 0.35726183482451 1179 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YBR225W Unknown Unknown Unknown
YBR230C YBR230C OM14 hom Verified 0.447940273946142 0.327098150789739 no 1515 0.338210932115599 1133 NA FT MITOCHONDRION Integral mitochondrial outer membrane protein; abundance is decreased in cells grown in glucose relative to other carbon sources; appears to contain 3 alpha-helical transmembrane segments; ORF encodes a 97-basepair intron biological_process molecular_function mitochondrion|integral to mitochondrial outer membrane
YPR066W YPR066W UBA3 hom Verified 0.447556184332594 0.327236765486381 no 1516 0.334203768260507 1129 NA Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern protein neddylation NEDD8 activating enzyme activity cytoplasm
YIL054W_p YIL054W YIL054W hom Uncharacterized 0.446972575474131 0.327447430601015 no 1517 0.331323443571265 1148 NA Protein of unknown function; expressed at both mRNA and protein levels biological_process molecular_function cellular_component
YDR475C YDR475C JIP4 hom Verified 0.446930928221786 0.327462466098868 no 1518 0.320431759010099 1070 NA Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence biological_process molecular_function cellular_component
YBL010C_p YBL010C YBL010C hom Uncharacterized 0.445822745982231 0.327862644966159 no 1519 0.325226069015311 1127 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles biological_process molecular_function clathrin-coated vesicle
YMR295C YMR295C YMR295C hom Verified 0.44530606744746 0.328049291853565 no 1520 0.316906754400546 1060 NA FT SITE OF POLARIZED GROWTH Protein of unknown function that associates with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud; YMR295C is not an essential gene; protein abundance increases in response to DNA replication stress biological_process molecular_function ribosome|cellular bud|mating projection tip
YKL201C YKL201C MNN4 hom Verified 0.445111408488804 0.32811962232495 no 1521 0.324432823008881 1104 NA FT CARBOHYDRATE METABOLISM Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication protein O-linked glycosylation|protein N-linked glycosylation|response to stress molecular_function membrane
YPL067C_p YPL067C YPL067C hom Uncharacterized 0.444824733809967 0.328223209260951 no 1522 0.315065044894771 1045 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL067C is not an essential gene biological_process molecular_function cytoplasm
YIR004W YIR004W DJP1 hom Verified 0.444765013528231 0.328244790231152 no 1523 0.306463767772189 1045 NA FT PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION Cytosolic J-domain-containing protein, required for peroxisomal protein import and involved in peroxisome assembly, homologous to E. coli DnaJ protein import into peroxisome matrix chaperone binding cytosol
YOL052C-A YOL052C-A DDR2 hom Verified 0.444738936104276 0.328254213945022 no 1524 0.328112482071753 1101 NA Multi-stress response protein; expression is activated by a variety of xenobiotic agents and environmental or physiological stresses; DDR2 has a paralog, HOR7, that arose from the whole genome duplication response to stress molecular_function fungal-type vacuole|cytoplasm
YPR017C YPR017C DSS4 hom Verified 0.444709865364488 0.328264719495487 no 1525 0.34025408958091 1129 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING Guanine nucleotide dissociation stimulator for Sec4p, functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol post-Golgi vesicle-mediated transport zinc ion binding|guanyl-nucleotide exchange factor activity cytosol|membrane
YBR221W-A_p YBR221W-A YBR221W-A hom Uncharacterized 0.444570461110706 0.328315099131273 no 1526 0.325620704722999 1072 NA Putative protein of unknown function; identified by expression profiling and mass spectrometry biological_process molecular_function cellular_component
YLR356W YLR356W ATG33 hom Verified 0.443627294618314 0.328656034305232 no 1527 0.321793927024883 1092 NA FT MITOCHONDRION Mitochondrial mitophagy-specific protein; required primarily for mitophagy induced at the post-log phase; not required for other types of selective autophagy or macroautophagy; conserved within fungi, but not in higher eukaryotes mitochondrion degradation molecular_function mitochondrion|integral to membrane
YLR090W YLR090W XDJ1 hom Verified 0.443591995536753 0.328668796964384 no 1528 0.347958174314041 1173 NA FT NUCLEUS|MITOCHONDRION Chaperone with a role in facilitating mitochondrial protein import; ascomycete-specific member of the DnaJ-like family, closely related to Ydj1p; predicted to be C-terminally prenylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies protein folding chaperone binding mitochondrion|integral to mitochondrial outer membrane|nucleus
YDR336W_p YDR336W YDR336W hom Uncharacterized 0.443259049405327 0.328789186073808 no 1529 0.338223438146241 1136 NA Putative protein of unknown function; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene biological_process molecular_function cellular_component
YLL042C YLL042C ATG10 hom Verified 0.44274912862235 0.328973601420525 no 1530 0.310910288180498 1029 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Conserved E2-like conjugating enzyme that mediates formation of the Atg12p-Atg5p conjugate, which is a critical step in autophagy piecemeal microautophagy of nucleus|cellular protein modification process|mitochondrion degradation|macroautophagy|CVT pathway Atg12 ligase activity cellular_component
YDL190C YDL190C UFD2 hom Verified 0.441295572045268 0.329499515662211 no 1531 0.335948040660914 1121 NA FT PROTEOLYSIS NUCLEUS Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3 ER-associated protein catabolic process|protein ubiquitination|ubiquitin-dependent protein catabolic process|response to stress ubiquitin-ubiquitin ligase activity nucleus|cytoplasm
YHL028W YHL028W WSC4 hom Verified 0.440272839920018 0.329869754739969 no 1532 0.317646803311587 1055 NA FT PROTEIN LOCALIZATION|CELL WALL ORG/BIOGENESIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM ER membrane protein involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3 response to heat|SRP-dependent cotranslational protein targeting to membrane, translocation|protein targeting to ER|response to stress transmembrane signaling receptor activity endoplasmic reticulum membrane
YDR508C YDR508C GNP1 hom Verified 0.439741720787528 0.33006209088661 no 1533 0.298972761900793 1021 NA FT MITOCHONDRION|PLASMA MEMBRANE High-affinity glutamine permease; also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids; GNP1 has a paralog, AGP1, that arose from the whole genome duplication amino acid transport|transmembrane transport amino acid transmembrane transporter activity|L-proline transmembrane transporter activity mitochondrion|integral to membrane|plasma membrane
YPL270W YPL270W MDL2 hom Verified 0.439725526496703 0.3300679560914 no 1534 0.333772706314037 1138 NA FT NUCLEOTIDE METABOLISM MITOCHONDRION Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, required for respiratory growth at high temperature; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis oligopeptide transport|oligopeptide export from mitochondrion oligopeptide-transporting ATPase activity mitochondrion|integral to membrane|mitochondrial inner membrane
YDL047W YDL047W SIT4 hom Verified 0.438971690463899 0.330341024604937 no 1535 0.334498013902234 1133 NA FT CELL CYCLE|RNA PROCESSING|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CYTOSKELETON ORGANIZATION|RESPONSE TO OXIDATIVE STRESS NUCLEUS Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization intracellular protein kinase cascade|replicative cell aging|G1/S transition of mitotic cell cycle|actin cytoskeleton organization|DNA repair|cellular response to oxidative stress|fungal-type cell wall organization|TOR signaling cascade|dephosphorylation|tRNA wobble uridine modification protein serine/threonine phosphatase activity nucleus|cytoplasm
YDR254W YDR254W CHL4 hom Verified 0.437429807450657 0.330899835499145 no 1536 0.328976170264642 1082 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME KINETOCHORE Outer kinetochore protein required for chromosome stability; involved in new kinetochore assembly and sister chromatid cohesion; peripheral component of the Ctf19 kinetochore complex that interacts with Ctf19p, Ctf3p, Iml3p and Mif2p; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-N and fission yeast mis15 kinetochore assembly|chromosome segregation|establishment of meiotic sister chromatid cohesion|protein localization to chromosome, centromeric region|maintenance of meiotic sister chromatid cohesion|establishment of mitotic sister chromatid cohesion structural molecule activity condensed nuclear chromosome outer kinetochore
YDL151C_d YDL151C BUD30 hom Dubious 0.437278873075915 0.330954557574234 no 1537 0.344587057373629 1149 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 96% of ORF overlaps the verified gene RPC53; diploid mutant displays a weak budding pattern phenotype in a systematic assay Unknown Unknown Unknown
YOR052C YOR052C YOR052C hom Verified 0.436633258985606 0.331188669213573 no 1538 0.332218139147405 1114 NA FT NUCLEUS Nuclear protein of unknown function; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner and by weak acid; transcriptionally regulated by Rpn4p along with proteasome subunit genes; putative ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus
YCR043C_p YCR043C YCR043C hom Uncharacterized 0.43598224432008 0.331424806036469 no 1539 0.341712422384834 1141 NA FT GOLGI APPARATUS|SITE OF POLARIZED GROWTH Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene biological_process molecular_function Golgi apparatus|mating projection tip
YER105C YER105C NUP157 hom Verified 0.435869544081 0.331465691611666 no 1540 0.295849651291448 1002 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and tethering of DNA to the nuclear periphery; both Nup170p and NUP157p are similar to human Nup155p; NUP157 has a paralog, NUP170, that arose from the whole genome duplication nucleocytoplasmic transport|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|mitotic cell cycle spindle assembly checkpoint|nuclear pore complex assembly|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery structural constituent of nuclear pore integral to membrane|nuclear pore|nuclear pore inner ring
YLL061W YLL061W MMP1 hom Verified 0.431606421094925 0.333013745397988 no 1541 0.326584217473333 1096 NA FT ENDOPLASMIC RETICULUM|PLASMA MEMBRANE High-affinity S-methylmethionine permease, required for utilization of S-methylmethionine as a sulfur source; has similarity to S-adenosylmethionine permease Sam3p S-methylmethionine transport S-methylmethionine transmembrane transporter activity integral to membrane|plasma membrane
YPR059C_d YPR059C YPR059C hom Dubious 0.430914597243875 0.333265234588837 no 1542 0.352060249910524 1200 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YMC1/YPR058W Unknown Unknown Unknown
YIR036C_p YIR036C IRC24 hom Uncharacterized 0.43036613660195 0.333464662219128 no 1543 0.335263343736472 1114 NA FT OXIDATION-REDUCTION PROCESS Putative benzil reductase;(GFP)-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS; sequence similarity with short-chain dehydrogenase/reductases; null mutant has increased spontaneous Rad52p foci biological_process molecular_function integral to membrane|cytoplasm
YKL053W_d YKL053W YKL053W hom Dubious 0.42961678781736 0.333737211558893 no 1544 0.315065493979843 1067 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF ASK1 Unknown Unknown Unknown
YMR316W YMR316W DIA1 hom Verified 0.429565279475463 0.333755949136623 no 1545 0.350332638470146 1159 NA Protein of unknown function, involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern pseudohyphal growth|invasive growth in response to glucose limitation molecular_function cytoplasm
YNL205C_d YNL205C YNL205C hom Dubious 0.429098594156424 0.333925737662782 no 1546 0.337528940020002 1128 NA Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YMR158C-A_p YMR158C-A YMR158C-A hom Uncharacterized 0.428835246504977 0.334021563292517 no 1547 0.311076333484539 1048 NA Putative protein of unknown function, may contain a lipid attachment site; YMR158C-A is not an essential gene biological_process molecular_function cellular_component
YHR146W YHR146W CRP1 hom Verified 0.428626687242285 0.334097460476248 no 1548 0.354097072623651 1186 NA FT NUCLEUS Protein that binds to cruciform DNA structures biological_process DNA binding nucleus
YOR104W YOR104W PIN2 hom Verified 0.428429019886004 0.334169400229182 no 1549 0.342724727554916 1147 NA Protein that induces appearance of [PIN+] prion when overproduced; predicted to be palmitoylated biological_process molecular_function cellular_component
YLR361C YLR361C DCR2 hom Verified 0.428274406508416 0.334225675012345 no 1550 0.309873736346576 1067 NA FT CELL CYCLE|SIGNALING Phosphoesterase involved in downregulation of the unfolded protein response, at least in part via dephosphorylation of Ire1p; dosage-dependent positive regulator of the G1/S phase transition through control of the timing of START endoplasmic reticulum unfolded protein response|traversing start control point of mitotic cell cycle|protein dephosphorylation hydrolase activity, acting on ester bonds|phosphoprotein phosphatase activity|phosphoric ester hydrolase activity cellular_component
YDR539W YDR539W FDC1 hom Verified 0.428259289388174 0.334231177405478 no 1551 0.32717300337508 1109 NA FT KETONE METABOLISM|COFACTOR METABOLISM PLASMA MEMBRANE Putative phenylacrylic acid decarboxylase; essential for the decarboxylation of aromatic carboxylic acids to the corresponding vinyl derivatives; homolog of E. coli UbiD; GFP-fusion protein localizes to the cytoplasm cinnamic acid catabolic process molecular_function cytoplasm
YOR081C YOR081C TGL5 hom Verified 0.427413959753633 0.334538920708936 no 1552 0.320918774519283 1058 NA FT LIPID METABOLISM Bifunctional enzyme with triacylglycerol lipase and lysophosphatidic acid acyltransferase activity; involved in triacylglycerol mobilization; localizes to lipid particles; potential Cdc28p substrate triglyceride mobilization lysophosphatidic acid acyltransferase activity|triglyceride lipase activity lipid particle
YFR045W_p YFR045W YFR045W hom Uncharacterized 0.427216797420421 0.334610713901822 no 1553 0.310001785070325 1066 NA FT MITOCHONDRION Putative mitochondrial transport protein; null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white transport transporter activity integral to membrane|mitochondrial inner membrane
YLR418C YLR418C CDC73 hom Verified 0.426971808651309 0.334699930675001 no 1554 0.442097180420391 1462 NA FF|FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION NUCLEUS|CHROMOSOME RNA POL II, HOLOENZYME Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; protein abundance increases in response to DNA replication stress transcription elongation from RNA polymerase I promoter|negative regulation of DNA recombination|mRNA 3'-end processing|recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex|positive regulation of transcription elongation from RNA polymerase II promoter|Unknown|regulation of transcription-coupled nucleotide-excision repair|transcription elongation from RNA polymerase II promoter chromatin binding|TFIIF-class binding transcription factor activity|RNA polymerase II core binding|RNA polymerase II transcription factor binding transcription factor activity nucleus|transcriptionally active chromatin|Cdc73/Paf1 complex
YOR053W_d YOR053W YOR053W hom Dubious 0.426810229314485 0.334758777610931 no 1555 0.327088039405748 1105 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VHS3/YOR054C Unknown Unknown Unknown
YDL112W YDL112W TRM3 hom Verified 0.426561077564799 0.334849526232942 no 1556 0.351503234179277 1170 NA FT RNA PROCESSING 2'-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs tRNA methylation tRNA (guanine) methyltransferase activity cytoplasm
YGR268C YGR268C HUA1 hom Verified 0.426404037820562 0.33490672982538 no 1557 0.346231982904914 1168 NA Cytoplasmic protein containing a zinc finger domain with sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly biological_process molecular_function cytoplasm
YMR141C_d YMR141C YMR141C hom Dubious 0.424661011869904 0.335541904686094 no 1558 0.338455466148395 1148 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YNL319W_d YNL319W YNL319W hom Dubious 0.424518503538866 0.335593856866939 no 1559 0.346059308496221 1155 NA Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HXT14 Unknown Unknown Unknown
YHL001W YHL001W RPL14B hom Verified 0.423994864005039 0.335784779469861 no 1560 0.325121966451558 1095 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L14B; homologous to mammalian ribosomal protein L14, no bacterial homolog; RPL14B has a paralog, RPL14A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress cytoplasmic translation structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YKL006W YKL006W RPL14A hom Verified 0.422865280124115 0.336196777886864 no 1561 0.35466444753862 1184 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L14A; N-terminally acetylated; homologous to mammalian ribosomal protein L14, no bacterial homolog; RPL14A has a paralog, RPL14B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YML026C YML026C RPS18B hom Verified 0.422730723927561 0.336245868327344 no 1562 0.330099999841741 1129 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION MITOCHONDRION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18B has a paralog, RPS18A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress cytoplasmic translation|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA export from nucleus structural constituent of ribosome cytosolic small ribosomal subunit|mitochondrion
YMR008C YMR008C PLB1 hom Verified 0.422391846387909 0.336369514154374 no 1563 0.328914843653398 1071 NA FT LIPID METABOLISM PLASMA MEMBRANE Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol glycerophospholipid metabolic process lysophospholipase activity periplasmic space|plasma membrane
YHR124W YHR124W NDT80 hom Verified 0.422363595639799 0.336379822769197 no 1564 0.325297494028171 1134 NA FT CELL CYCLE|CELL DIVISION NUCLEUS|CHROMOSOME Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE) meiosis|transcription, DNA-dependent sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nuclear chromosome
YGR138C YGR138C TPO2 hom Verified 0.422098057618588 0.336476722822153 no 1565 0.292116105629816 997 NA FT PLASMA MEMBRANE Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; TPO2 has a paralog, TPO3, that arose from the whole genome duplication spermine transport spermine transmembrane transporter activity fungal-type vacuole membrane|integral to membrane|plasma membrane
YGL136C YGL136C MRM2 hom Verified 0.422016790014776 0.336506381142122 no 1566 0.317420547010785 1078 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS MITOCHONDRION Mitochondrial 2' O-ribose methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ rRNA methylation rRNA (uridine-2'-O-)-methyltransferase activity mitochondrion
YLR402W_d YLR402W YLR402W hom Dubious 0.421008012579098 0.336874615470204 no 1567 0.345047148901633 1162 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YBR216C YBR216C YBP1 hom Verified 0.420901264569994 0.336913590885269 no 1568 0.32814878893865 1111 NA FT RESPONSE TO OXIDATIVE STRESS Protein involved in cellular response to oxidative stress; required for oxidation of specific cysteine residues of transcription factor Yap1p, resulting in nuclear localization of Yap1p in response to stress; YBP1 has a paralog, YBP2, that arose from the whole genome duplication cellular response to oxidative stress molecular_function cytoplasm
YGR142W YGR142W BTN2 hom Verified 0.420042983322923 0.337227026786562 no 1569 0.337443277286814 1123 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ION HOMEOSTASIS|ION HOMEOSTASIS v-SNARE binding protein; facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase; BTN2 has a paralog, CUR1, that arose from the whole genome duplication intracellular protein transport|amino acid transport|retrograde transport, endosome to Golgi|regulation of pH SNARE binding cytosol|late endosome|perinuclear region of cytoplasm
YBL086C_p YBL086C YBL086C hom Uncharacterized 0.419719258220975 0.337345277385253 no 1570 0.322678373516969 1080 NA Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery biological_process molecular_function cellular_component
YJR078W YJR078W BNA2 hom Verified 0.418759193642843 0.337696065093945 no 1571 0.322123847551102 1083 NA FT OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for de novo biosynthesis of NAD from tryptophan via kynurenine; interacts genetically with telomere capping gene CDC13; regulated by Hst1p and Aftp de novo NAD biosynthetic process from tryptophan tryptophan 2,3-dioxygenase activity|indoleamine 2,3-dioxygenase activity cytoplasm
YMR082C_d YMR082C YMR082C hom Dubious 0.418644000229999 0.337738163863736 no 1572 0.353566346087628 1167 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPR111W YPR111W DBF20 hom Verified 0.417355166431098 0.33820932146147 no 1573 0.315435488736881 1060 NA FT CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION SITE OF POLARIZED GROWTH|CYTOSKELETON Ser/Thr kinase involved in late nuclear division, one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs cytokinesis after mitosis|protein phosphorylation|barrier septum assembly involved in cell cycle cytokinesis|regulation of mRNA catabolic process|exit from mitosis protein serine/threonine kinase activity spindle pole body|cellular bud neck|cytoplasm
YCL005W YCL005W LDB16 hom Verified 0.417021632547617 0.338331292404255 no 1574 0.36594197332723 1253 NA FT MITOCHONDRION Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria biological_process molecular_function mitochondrion|lipid particle
YLL025W YLL025W PAU17 hom Verified 0.415438415768065 0.338910494614259 no 1575 0.314089218788855 1043 NA Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; YLL025W is not an essential gene biological_process molecular_function cellular_component
YKL109W YKL109W HAP4 hom Verified 0.415285848977936 0.338966329623797 no 1576 0.336806929032434 1117 NA FT TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex regulation of cellular respiration|carbon catabolite activation of transcription from RNA polymerase II promoter RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor binding transcription factor activity CCAAT-binding factor complex
YER187W_p YER187W YER187W hom Uncharacterized 0.41497878349873 0.339078717386155 no 1577 0.323287943034353 1091 NA Putative protein of unknown function; induced in respiratory-deficient cells biological_process molecular_function cellular_component
YOR120W YOR120W GCY1 hom Verified 0.413861172516311 0.339487890406528 no 1578 0.366533952609233 1174 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS NUCLEUS Glycerol dehydrogenase;involved in an alternative pathway for glycerol catabolism used under microaerobic conditions; also has mRNA binding activity; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress; GCY1 has a paralog, YPR1, that arose from the whole genome duplication cellular response to oxidative stress|arabinose catabolic process|D-xylose catabolic process oxidoreductase activity|mRNA binding|alditol:NADP+ 1-oxidoreductase activity|aldo-keto reductase (NADP) activity nucleus|cytoplasm
YLR262C-A YLR262C-A TMA7 hom Verified 0.412140423487861 0.340118250662962 no 1579 0.323615442077282 1097 NA FT TRANSLATION NUCLEUS Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin; protein abundance increases in response to DNA replication stress cytoplasmic translation molecular_function nucleus|cytoplasm
YDR143C YDR143C SAN1 hom Verified 0.411317902838454 0.340419721890172 no 1580 0.345416408850482 1163 NA FT PROTEOLYSIS NUCLEUS Ubiquitin-protein ligase; involved in the proteasome-dependent degradation of aberrant nuclear proteins; targets substrates with regions of exposed hydrophobicity containing 5 or more contiguous hydrophobic residues; contains intrinsically disordered regions that contribute to substrate recognition nucleus-associated proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to misfolded protein|response to stress ubiquitin-protein ligase activity nucleus|cytoplasm
YOR100C YOR100C CRC1 hom Verified 0.411293796199221 0.340428559023193 no 1581 0.324180724079592 1117 NA FT KETONE METABOLISM|LIPID METABOLISM MITOCHONDRION Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation fatty acid metabolic process carnitine:acyl carnitine antiporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YPL042C YPL042C SSN3 hom Verified 0.406724583960564 0.342105141190628 no 1582 0.364298452927435 1234 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS NUCLEUS Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression phosphorylation of RNA polymerase II C-terminal domain|negative regulation of transcription from RNA polymerase II promoter|negative regulation of filamentous growth|protein phosphorylation|protein destabilization|nuclear-transcribed mRNA catabolic process, non-stop decay|positive regulation of transcription from RNA polymerase II promoter by galactose RNA polymerase II carboxy-terminal domain kinase activity|protein kinase activity|cyclin-dependent protein kinase activity mediator complex
YPL032C YPL032C SVL3 hom Verified 0.405975595333279 0.342380266055623 no 1583 0.373773707408513 1249 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS SITE OF POLARIZED GROWTH Protein of unknown function; mutant phenotype suggests a potential role in vacuolar function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; relocalizes from bud neck to cytoplasm upon DNA replication stress endocytosis molecular_function cellular bud|cellular bud neck|cytoplasm
YNL135C YNL135C FPR1 hom Verified 0.405959918482106 0.342386025504181 no 1584 0.35432784990184 1197 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|CHROMATIN ORGANIZATION NUCLEUS|MITOCHONDRION Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function protein folding|chromatin organization|homoserine metabolic process peptidyl-prolyl cis-trans isomerase activity|macrolide binding mitochondrion|nucleus|cytoplasm
YGR275W YGR275W RTT102 hom Verified 0.405893207552735 0.342410534545367 no 1585 0.355604678363183 1155 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|CHROMOSOME SEGREGATION NUCLEUS RSC COMPLEX Component of both the SWI/SNF and RSC chromatin remodeling complexes; suggested role in chromosome maintenance; possible weak regulator of Ty1 transposition; protein abundance increases in response to DNA replication stress chromosome segregation|nucleosome disassembly|chromatin remodeling|transcription elongation from RNA polymerase II promoter molecular_function RSC complex|SWI/SNF complex|nucleus
YAR018C YAR018C KIN3 hom Verified 0.404440723679548 0.342944329424757 no 1586 0.358902742009162 1200 NA FT PROTEIN PHOSPHORYLATION|CHROMOSOME SEGREGATION Nonessential serine/threonine protein kinase; possible role in DNA damage response chromosome segregation|protein phosphorylation protein kinase activity cellular_component
YDR049W YDR049W VMS1 hom Verified 0.403793318003717 0.343182355273869 no 1587 0.343508318205195 1157 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans ER-associated protein catabolic process|mitochondria-associated protein catabolic process|nucleus-associated proteasomal ubiquitin-dependent protein catabolic process molecular_function cytosol|mitochondrion|endoplasmic reticulum membrane|Cdc48p-Npl4p-Vms1p AAA ATPase complex|cytoplasm
YLR400W_d YLR400W YLR400W hom Dubious 0.403723731696743 0.343207943153886 no 1588 0.344368740551126 1143 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YER051W YER051W JHD1 hom Verified 0.403665376146176 0.343229401878398 no 1589 0.336878038552717 1103 NA FT CHROMATIN ORGANIZATION|OXIDATION-REDUCTION PROCESS NUCLEUS JmjC domain family histone demethylase specific for H3-K36, similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe histone demethylation methylated histone residue binding|histone demethylase activity (H3-K36 specific) cellular_component
YPL212C YPL212C PUS1 hom Verified 0.402818448603822 0.343540894162131 no 1590 0.328340086559005 1094 NA FT RNA PROCESSING NUCLEUS tRNA:pseudouridine synthase, introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA; nuclear protein that appears to be involved in tRNA export; also acts on U2 snRNA snRNA pseudouridine synthesis|tRNA pseudouridine synthesis pseudouridine synthase activity nucleus
YDR378C YDR378C LSM6 hom Verified 0.402452785960046 0.343675414434551 no 1591 0.352841723343922 1186 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA nuclear-transcribed mRNA catabolic process|mRNA splicing, via spliceosome|maturation of SSU-rRNA RNA binding U6 snRNP|nucleolus|small nucleolar ribonucleoprotein complex|U4/U6 x U5 tri-snRNP complex|cytoplasmic mRNA processing body
YHL012W_p YHL012W YHL012W hom Uncharacterized 0.401846276602215 0.343898581237846 no 1592 0.316821672420632 1089 NA Putative UTP glucose-1-phosphate uridylyltransferase; YHL012W has a paralog, UGP1, that arose from the whole genome duplication biological_process molecular_function cellular_component
YDL216C YDL216C RRI1 hom Verified 0.401592563499365 0.343991951820115 no 1593 0.343579794636397 1164 NA FT SIGNALING|PROTEOLYSIS NUCLEUS Catalytic subunit of the COP9 signalosome (CSN) complex that acts as an isopeptidase in cleaving the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; metalloendopeptidase involved in the adaptation to pheromone signaling adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|cullin deneddylation metalloendopeptidase activity signalosome
YIR007W_p YIR007W YIR007W hom Uncharacterized 0.400872404801531 0.344257033842592 no 1594 0.335248075915477 1082 NA FT CARBOHYDRATE METABOLISM Putative glycosidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YIR007W is a non-essential gene biological_process molecular_function cytoplasm
YBL104C YBL104C SEA4 hom Verified 0.39976746513458 0.344663898019196 no 1595 0.448631252880181 1502 NA Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; has an N-terminal beta-propeller fold and a C-terminal RING motif; promoter contains multiple GCN4 binding sites biological_process molecular_function Seh1-associated complex|extrinsic to fungal-type vacuolar membrane|cytoplasm
YGL032C YGL032C AGA2 hom Verified 0.399426544656144 0.344789469081094 no 1596 0.342329873399848 1152 NA Adhesion subunit of a-agglutinin of a-cells, C-terminal sequence acts as a ligand for alpha-agglutinin (Sag1p) during agglutination, modified with O-linked oligomannosyl chains, linked to anchorage subunit Aga1p via two disulfide bonds agglutination involved in conjugation with cellular fusion cell adhesion molecule binding fungal-type cell wall
YIR027C YIR027C DAL1 hom Verified 0.398940814822574 0.34496840723277 no 1597 0.356064494392136 1201 NA Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression allantoin assimilation pathway allantoinase activity cellular_component
YOR196C YOR196C LIP5 hom Verified 0.397984139479641 0.345320938511104 no 1598 0.359589523930378 1200 NA FT KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM MITOCHONDRION Protein involved in biosynthesis of the coenzyme lipoic acid, has similarity to E. coli lipoic acid synthase protein lipoylation lipoate synthase activity mitochondrion
YGR236C YGR236C SPG1 hom Verified 0.397559758694948 0.345477364241011 no 1599 0.344670851909819 1177 NA FT MITOCHONDRION Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YBR296C YBR296C PHO89 hom Verified 0.397250159018968 0.345591498584692 no 1600 0.345672665910519 1184 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p; mutations in related human transporter genes hPit1 and hPit2 are associated with hyperphosphatemia-induced calcification of vascular tissue and familial idiopathic basal ganglia calcification phosphate ion transport|transmembrane transport sodium:inorganic phosphate symporter activity integral to membrane|plasma membrane
YKL070W_p YKL070W YKL070W hom Uncharacterized 0.396824524479413 0.345748432253557 no 1601 0.314674058351381 1064 NA FT OXIDATION-REDUCTION PROCESS MITOCHONDRION Putative protein of unknown function; expression induced in cells treated with mycotoxins patulin or citrinin; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YDL109C_p YDL109C YDL109C hom Uncharacterized 0.395362278555671 0.346287771750442 no 1602 0.367798268133012 1228 NA FT LIPID METABOLISM Putative lipase; involved in lipid metabolism; not an essential gene; YDL109C has a paralog, ROG1, that arose from the whole genome duplication cellular lipid metabolic process molecular_function cellular_component
YJL128C YJL128C PBS2 hom Verified 0.393374959023605 0.34702128089536 no 1603 0.377895258645368 1246 NA FF|FT PROTEIN LOCALIZATION|SIGNALING|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION SITE OF POLARIZED GROWTH MAP kinase kinase of the HOG signaling pathway; activated under severe osmotic stress; mitophagy-specific regulator; plays a role in regulating Ty1 transposition activation of MAPK activity involved in osmosensory signaling pathway|actin filament organization|MAPK import into nucleus involved in osmosensory signaling pathway|protein phosphorylation|hyperosmotic response|osmosensory signaling pathway|cellular response to heat MAP-kinase scaffold activity|MAP kinase kinase activity|protein kinase activity cellular bud neck|cytoplasm|cellular bud tip
YMR320W_d YMR320W YMR320W hom Dubious 0.393225870514288 0.347076331839286 no 1604 0.340017922617301 1160 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YHR127W YHR127W YHR127W hom Verified 0.392408828119658 0.347378082090481 no 1605 0.343168871335921 1124 NA FT CELL CYCLE|CYTOSKELETON ORGANIZATION NUCLEUS Protein of unknown function; localizes to the nucleus; required for asymmetric localization of Kar9p during mitosis mitotic spindle elongation molecular_function nucleus
YAL031C YAL031C GIP4 hom Verified 0.392059377644502 0.347507170758394 no 1606 0.338777774138073 1119 NA FT CHROMOSOME SEGREGATION Cytoplasmic Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; potential Cdc28p substrate chromosome segregation|regulation of phosphoprotein phosphatase activity protein phosphatase 1 binding|protein phosphatase type 1 regulator activity cytoplasm
YPL021W YPL021W ECM23 hom Verified 0.390344093691519 0.34814106103877 no 1607 0.32365123903638 1079 NA FT CELL WALL ORG/BIOGENESIS Non-essential protein of unconfirmed function; affects pre-rRNA processing, may act as a negative regulator of the transcription of genes involved in pseudohyphal growth; homologous to Srd1p pseudohyphal growth sequence-specific DNA binding cellular_component
YER067W YER067W RGI1 hom Verified 0.390342019784177 0.348141827717101 no 1608 0.3241041694915 1080 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS|PLASMA MEMBRANE Protein of unknown function; involved in energy metabolism under respiratory conditions; protein abundance is increased upon intracellular iron depletion; protein abundance increases in response to DNA replication stress energy reserve metabolic process molecular_function cell periphery|nucleus|cytoplasm
YPL014W_p YPL014W YPL014W hom Uncharacterized 0.388065866944972 0.348983645326113 no 1609 0.345130467812054 1158 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus biological_process molecular_function nucleus|cytoplasm
YBR012C_d YBR012C YBR012C hom Dubious 0.387936452185033 0.349031530764422 no 1610 0.346734757943745 1139 NA Dubious open reading frame, unlikely to encode a functional protein; expression induced by iron-regulated transcriptional activator Aft2p Unknown Unknown Unknown
YGR134W YGR134W CAF130 hom Verified 0.387110668704707 0.34933713985286 no 1611 0.323730500742487 1063 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter molecular_function CCR4-NOT core complex
YPL025C_d YPL025C YPL025C hom Dubious 0.386264007145091 0.349650577024991 no 1612 0.35648529115827 1189 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YNR019W YNR019W ARE2 hom Verified 0.385170973319111 0.350055373685746 no 1613 0.35295602867083 1170 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen; ARE2 has a paralog, ARE1, that arose from the whole genome duplication ergosterol metabolic process ergosterol O-acyltransferase activity integral to membrane|endoplasmic reticulum
YER027C YER027C GAL83 hom Verified 0.38501241385611 0.350114109128741 no 1614 0.343320653282879 1118 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|SIGNALING|PROTEIN PHOSPHORYLATION ENDOMEMBRANE SYSTEM|NUCLEUS One of three possible beta-subunits of the Snf1 kinase complex, allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source; contains glycogen-binding domain signal transduction|cell adhesion|protein phosphorylation|invasive growth in response to glucose limitation|regulation of protein complex assembly AMP-activated protein kinase activity AMP-activated protein kinase complex|nucleus|nuclear envelope lumen|cytoplasm
YHR073W YHR073W OSH3 hom Verified 0.385010791734241 0.350114710032548 no 1615 0.341256438976824 1130 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOPLASMIC RETICULUM Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability karyogamy involved in conjugation with cellular fusion|endocytosis|exocytosis|positive regulation of phosphatase activity|maintenance of cell polarity|pseudohyphal growth|sterol transport|invasive growth in response to glucose limitation lipid binding|oxysterol binding|1-phosphatidylinositol binding|sterol transporter activity cortical endoplasmic reticulum|cytoplasm
YFL044C YFL044C OTU1 hom Verified 0.384473132839406 0.350313902713521 no 1616 0.331586577721841 1122 NA FT PROTEOLYSIS NUCLEUS Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family; protein abundance increases in response to DNA replication stress protein deubiquitination|regulation of transcription, DNA-dependent ubiquitin-specific protease activity nucleus|cytoplasm
YBR269C_p YBR269C FMP21 hom Uncharacterized 0.384331035710086 0.35036655395499 no 1617 0.350938450537037 1182 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YNL162W-A_p YNL162W-A YNL162W-A hom Uncharacterized 0.383352018329688 0.350729387316403 no 1618 0.343073372188026 1137 NA FT NUCLEUS Putative protein of unknown function; identified by homology biological_process molecular_function nucleus|cytoplasm
YNL090W YNL090W RHO2 hom Verified 0.382823567750518 0.350925292859034 no 1619 0.357309181347519 1193 NA FT SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION PLASMA MEMBRANE Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, involved in the establishment of cell polarity and in microtubule assembly microtubule-based process|fungal-type cell wall organization|actin filament organization|establishment of cell polarity|small GTPase mediated signal transduction GTPase activity membrane
YPL070W YPL070W MUK1 hom Verified 0.381863984844551 0.351281127727103 no 1620 0.344759226048435 1144 NA Cytoplasmic protein of unknown function containing a Vps9 domain; computational analysis of large-scale protein-protein interaction data suggests a possible role in transcriptional regulation biological_process molecular_function cytoplasm
YPL134C YPL134C ODC1 hom Verified 0.381553119607702 0.351396431511646 no 1621 0.344523860644384 1170 NA FT MITOCHONDRION Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation mitochondrial transport dicarboxylic acid transmembrane transporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YMR030W YMR030W RSF1 hom Verified 0.380036952600985 0.351958992570926 no 1622 0.333617854474194 1128 NA FT TRANSCRIPTION FROM RNA POL II|SIGNALING|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS|MITOCHONDRION Protein required for respiratory growth; localized to both the nucleus and mitochondrion; may interact with transcription factors to mediate the transition to respiratory growth and activate transcription of nuclear and mitochondrial genes transcription from mitochondrial promoter|calcium-mediated signaling|transcription from RNA polymerase II promoter|aerobic respiration molecular_function mitochondrion|nucleus
YDR221W YDR221W GTB1 hom Verified 0.379835983164201 0.352033584957566 no 1623 0.344881850800236 1157 NA FT CARBOHYDRATE METABOLISM ENDOPLASMIC RETICULUM Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p; involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER; relocalizes from ER to cytoplasm upon DNA replication stress polysaccharide biosynthetic process|protein N-linked glycosylation alpha-glucosidase activity glucosidase II complex|endoplasmic reticulum|endoplasmic reticulum lumen
YBL044W_p YBL044W YBL044W hom Uncharacterized 0.379326022357715 0.352222889009237 no 1624 0.342440126822817 1142 NA Putative protein of unknown function; YBL044W is not an essential protein biological_process molecular_function cellular_component
YKR020W YKR020W VPS51 hom Verified 0.378901951877922 0.352380337351701 no 1625 0.374247957895578 1252 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL DIVISION|VACUOLAR TRANSPORT GOLGI APPARATUS Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; links the (VFT/GARP) complex to the SNARE Tlg1p vesicle organization|retrograde transport, endosome to Golgi|budding cell apical bud growth|regulation of cell size|protein targeting to vacuole protein binding Golgi apparatus|GARP complex
YMR151W_d YMR151W YIM2 hom Dubious 0.377486258914764 0.352906137093571 no 1626 0.345418741476909 1152 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1 Unknown Unknown Unknown
YJL138C YJL138C TIF2 hom Verified 0.377261986230503 0.35298945958374 no 1627 0.348137633692642 1156 NA FT TRANSLATION RIBOSOME Translation initiation factor eIF4A; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; protein abundance increases in response to DNA replication stress; TIF2 has a paralog, TIF1, that arose from the whole genome duplication translational initiation|regulation of translational initiation ATP-dependent RNA helicase activity|translation initiation factor activity ribosome|eukaryotic translation initiation factor 4F complex|plasma membrane|cytoplasm
YBR081C YBR081C SPT7 hom Verified 0.376720711064954 0.353190584862501 no 1628 0.405282147378182 1336 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION NUCLEUS|MITOCHONDRION HISTONE ACETYLTRANSFERASE Subunit of the SAGA transcriptional regulatory complex, involved in proper assembly of the complex; also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex conjugation with cellular fusion|histone acetylation|protein complex assembly|chromatin modification structural molecule activity SLIK (SAGA-like) complex|mitochondrion|SAGA complex
YEL046C YEL046C GLY1 hom Verified 0.375475161770796 0.353653557750037 no 1629 0.381504913361448 1247 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Threonine aldolase, catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis threonine catabolic process|glycine biosynthetic process threonine aldolase activity|L-allo-threonine aldolase activity cytosol
YML052W YML052W SUR7 hom Verified 0.375276935758548 0.353727258703199 no 1630 0.331339696709618 1136 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION MITOCHONDRION|PLASMA MEMBRANE Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants endocytosis|ascospore formation molecular_function cell cortex|eisosome|mitochondrion|membrane raft|integral to membrane|plasma membrane|actin cortical patch
YJL165C YJL165C HAL5 hom Verified 0.372178164808269 0.354880101105323 no 1631 0.335932375891009 1088 NA FT PROTEIN LOCALIZATION|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication cellular cation homeostasis|protein phosphorylation|cellular protein localization|protein dephosphorylation protein kinase activity cellular_component
YGL158W YGL158W RCK1 hom Verified 0.371574616129551 0.355104795700812 no 1632 0.343087777426376 1140 NA FT CELL CYCLE|PROTEIN PHOSPHORYLATION Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations; RCK1 has a paralog, RCK2, that arose from the whole genome duplication protein phosphorylation|regulation of meiosis protein serine/threonine kinase activity|protein kinase activity cellular_component
YGR020C YGR020C VMA7 hom Verified 0.371204031890861 0.355242785150493 no 1633 0.385619971791263 1310 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane vacuolar acidification proton-transporting ATPase activity, rotational mechanism fungal-type vacuole membrane|vacuolar proton-transporting V-type ATPase, V1 domain|integral to membrane
YLR341W YLR341W SPO77 hom Verified 0.370889695637637 0.35535984517799 no 1634 0.359360021814776 1182 NA FT CELL WALL ORG/BIOGENESIS Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis ascospore wall assembly|ascospore formation molecular_function intracellular
YMR272W-B_p YMR272W-B YMR272W-B hom Uncharacterized 0.368360991355999 0.356302040026157 no 1635 0.317133165178268 1087 NA Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YOR307C YOR307C SLY41 hom Verified 0.368160484136227 0.356376786626794 no 1636 0.370065333794252 1218 NA FT VESICLE-MEDIATED TRANSPORT ENDOPLASMIC RETICULUM Protein involved in ER-to-Golgi transport ER to Golgi vesicle-mediated transport molecular_function integral to membrane|endoplasmic reticulum
YBL032W YBL032W HEK2 hom Verified 0.366958717679959 0.356824905789355 no 1637 0.352585886204877 1184 NA FT CHROMATIN ORGANIZATION|TRANSLATION|RNA LOCALIZATION NUCLEUS|CHROMOSOME RNA binding protein involved in the asymmetric localization of ASH1 mRNA; represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phosphoryation; regulates telomere position effect and length; similarity to hnRNP-K telomere maintenance via telomerase|intracellular mRNA localization|mRNA stabilization mRNA binding nuclear chromosome, telomeric region|cytoplasmic mRNA processing body|cytoplasm
YMR230W YMR230W RPS10B hom Verified 0.366645415963106 0.356941763408457 no 1638 0.368622086864783 1238 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10B has a paralog, RPS10A, that arose from the whole genome duplication cytoplasmic translation|rRNA export from nucleus structural constituent of ribosome cytosolic small ribosomal subunit
YJR099W YJR099W YUH1 hom Verified 0.366641376721056 0.35694327008286 no 1639 0.347716857568532 1157 NA FT PROTEOLYSIS Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p protein deubiquitination ubiquitin-specific protease activity cytoplasm
YMR153C-A_d YMR153C-A YMR153C-A hom Dubious 0.366102216509555 0.357144401814519 no 1640 0.317827791450588 1066 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NUP53 Unknown Unknown Unknown
YJL132W_p YJL132W YJL132W hom Uncharacterized 0.365558573686292 0.357347245969241 no 1641 0.361160847813288 1195 NA Putative protein of unknown function; localizes to the membrane fraction; possible Zap1p-regulated target gene induced by zinc deficiency; YJL132W is a non-essential gene biological_process molecular_function membrane
YLR095C YLR095C IOC2 hom Verified 0.36434053913593 0.357801865620555 no 1642 0.355978635236522 1215 NA FT CHROMATIN ORGANIZATION NUCLEUS Member of a complex (Isw1b) with Isw1p and Ioc4p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PHD finger motif chromatin remodeling protein binding|nucleosome binding|ATPase activity|DNA binding ISW1 complex
YER066W_p YER066W RRT13 hom Uncharacterized 0.362691124591897 0.358417815238133 no 1643 0.337479772368981 1162 NA Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription biological_process molecular_function cellular_component
YLR098C YLR098C CHA4 hom Verified 0.360189415305595 0.359352744805536 no 1644 0.369886164263754 1188 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS DNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain positive regulation of transcription, DNA-dependent|cellular amino acid catabolic process sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nucleus
YKR005C_p YKR005C YKR005C hom Uncharacterized 0.359568310532781 0.359584992590139 no 1645 0.351844869404734 1192 NA Putative protein of unknown function biological_process molecular_function cellular_component
YDL080C YDL080C THI3 hom Verified 0.359075005594592 0.359769489543371 no 1646 0.353455963217223 1160 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Probable alpha-ketoisocaproate decarboxylase, may have a role in catabolism of amino acids to long-chain and complex alcohols; required for expression of enzymes involved in thiamine biosynthesis regulation of thiamine biosynthetic process|branched-chain amino acid catabolic process to alcohol via Ehrlich pathway|positive regulation of transcription from RNA polymerase II promoter|leucine catabolic process carboxy-lyase activity cytosol|nucleus
YKR103W YKR103W NFT1 hom Verified 0.358875320472745 0.359844181440691 no 1647 0.365034313979993 1225 NA FT NUCLEOTIDE METABOLISM Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds. transport ATPase activity, coupled to transmembrane movement of substances integral to membrane|membrane
YBR069C YBR069C TAT1 hom Verified 0.358006108663284 0.360169371042142 no 1648 0.465871546088395 1524 NA FF|FT PLASMA MEMBRANE Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress amino acid transport|tyrosine transport|tryptophan transport|transmembrane transport amino acid transmembrane transporter activity|low-affinity tryptophan transmembrane transporter activity integral to membrane|plasma membrane
YBL065W_d YBL065W YBL065W hom Dubious 0.357538850613449 0.360344223506855 no 1649 0.376197702307206 1225 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene Unknown Unknown Unknown
YBR036C YBR036C CSG2 hom Verified 0.35752442601987 0.360349621793784 no 1650 0.373320642319336 1231 NA FF|FT LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Endoplasmic reticulum membrane protein, required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations; protein abundance increases in response to DNA replication stress cellular calcium ion homeostasis|glycosphingolipid biosynthetic process enzyme regulator activity integral to endoplasmic reticulum membrane|integral to membrane
YBR149W YBR149W ARA1 hom Verified 0.357453890809382 0.360376019424014 no 1651 0.350362289865674 1196 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM NADP+ dependent arabinose dehydrogenase, involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product cellular carbohydrate metabolic process alditol:NADP+ 1-oxidoreductase activity|D-arabinose 1-dehydrogenase [NAD(P)+] activity cytosol
YGR003W YGR003W CUL3 hom Verified 0.355666273602689 0.361045252669322 no 1652 0.35306833570847 1141 NA FT PROTEOLYSIS NUCLEUS UBIQUITIN LIGASE COMPLEX Ubiquitin-protein ligase, forms a complex with Elc1p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; cullin family member with similarity to Cdc53p and human CUL3 protein ubiquitination involved in ubiquitin-dependent protein catabolic process|ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity nucleus|Cul3-RING ubiquitin ligase complex|cytoplasm
YKR073C_d YKR073C YKR073C hom Dubious 0.354916380725164 0.361326118153045 no 1653 0.391597136198931 1291 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YHR161C YHR161C YAP1801 hom Verified 0.353301201745217 0.361931322343954 no 1654 0.362741341186129 1206 NA FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1801 has a paralog, YAP1802, that arose from the whole genome duplication endocytosis clathrin binding actin cortical patch
YIL105C YIL105C SLM1 hom Verified 0.353257128707191 0.361947841267334 no 1655 0.345438587687359 1141 NA FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|SIGNALING|CYTOSKELETON ORGANIZATION MITOCHONDRION|PLASMA MEMBRANE Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; protein abundance increases in response to DNA replication stress; SLM1 has a paralog, SLM2, that arose from the whole genome duplication eisosome assembly|TOR signaling cascade|regulation of cell growth|actin filament bundle assembly|endosomal transport|establishment or maintenance of actin cytoskeleton polarity|actin cytoskeleton organization phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol binding|sphingolipid binding eisosome|mitochondrion|membrane raft|plasma membrane|cytoplasm
YER139C YER139C RTR1 hom Verified 0.352831749510075 0.362107289972347 no 1656 0.345013434079989 1164 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS CTD phosphatase; dephosphorylates S5-P in the C-terminal domain of Rpo21p; has a cysteine-rich motif required for function and conserved in eukaryotes; shuttles between the nucleus and cytoplasm; RTR1 has a paralog, RTR2, that arose from the whole genome duplication dephosphorylation of RNA polymerase II C-terminal domain|transcription from RNA polymerase II promoter CTD phosphatase activity nucleus|cytoplasm
YPL177C YPL177C CUP9 hom Verified 0.351937692626586 0.362442495327012 no 1657 0.36628743089029 1240 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Homeodomain-containing transcriptional repressor; regulates expression of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription; CUP9 has a paralog, TOS8, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter|negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter RNA polymerase II repressing transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity nucleus
YEL003W YEL003W GIM4 hom Verified 0.351545085828707 0.362589727250667 no 1658 0.353162938293131 1170 NA FT PROTEIN COMPLEX ORG/BIOGENESIS Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it tubulin complex assembly tubulin binding prefoldin complex|cytoplasm
YGL041C_d YGL041C YGL041C hom Dubious 0.350756842194337 0.362885388735359 no 1659 0.370771065809028 1215 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR350W YLR350W ORM2 hom Verified 0.347479776367921 0.364115454621414 no 1660 0.366971273565046 1220 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Evolutionarily conserved protein, similar to Orm1p; required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control; protein abundance increases in response to DNA replication stress cellular sphingolipid homeostasis|negative regulation of sphingolipid biosynthetic process|response to unfolded protein molecular_function integral to membrane|endoplasmic reticulum|SPOTS complex
YBR013C_p YBR013C YBR013C hom Uncharacterized 0.345005650706411 0.365045061307487 no 1661 0.37795283711279 1260 NA Putative protein of unknown function, haploid deletion mutant exhibits synthetic phenotype with alpha-synuclein biological_process molecular_function cellular_component
YHR079C YHR079C IRE1 hom Verified 0.344531650965684 0.365223248656969 no 1662 0.387987236532858 1278 NA FF|FT RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress endoplasmic reticulum unfolded protein response|fungal-type cell wall organization|inositol metabolic process|protein phosphorylation unfolded protein binding|protein serine/threonine kinase activity|endoribonuclease activity|protein kinase activity|protein homodimerization activity nucleus
YDL033C YDL033C SLM3 hom Verified 0.344125648053545 0.365375897582997 no 1663 0.372014132698802 1259 NA FT RNA PROCESSING|MITOCHONDRION ORGANIZATION MITOCHONDRION tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF) mitochondrial tRNA thio-modification tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity mitochondrion
YCR073C YCR073C SSK22 hom Verified 0.344101604867514 0.365384938006347 no 1664 0.346135749715616 1176 NA FT SIGNALING|PROTEIN PHOSPHORYLATION MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; functionally redundant with, and homologous to, Ssk2p; interacts with and is activated by Ssk1p; phosphorylates Pbs2p MAPK cascade involved in osmosensory signaling pathway|protein phosphorylation protein kinase activity|MAP kinase kinase kinase activity cellular_component
YOR270C YOR270C VPH1 hom Verified 0.343936345224591 0.365447078930053 no 1665 0.352156051345157 1164 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS Subunit a of vacuolar-ATPase V0 domain; one of two isoforms (Vph1p and Stv1p); Vph1p is located in V-ATPase complexes of the vacuole while Stv1p is located in V-ATPase complexes of the Golgi and endosomes; relative distribution to the vacuolar membrane decreases upon DNA replication stress polyphosphate metabolic process|proton transport|protein complex assembly|vacuolar acidification proton-transporting ATPase activity, rotational mechanism vacuolar proton-transporting V-type ATPase, V0 domain|fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YEL030W YEL030W ECM10 hom Verified 0.343503051264304 0.365610022873137 no 1666 0.348089060530874 1170 NA FT PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Heat shock protein of the Hsp70 family; localized in mitochondrial nucleoids, plays a role in protein translocation, interacts with Mge1p in an ATP-dependent manner; overexpression induces extensive mitochondrial DNA aggregations; ECM10 has a paralog, SSC1, that arose from the whole genome duplication protein refolding|protein targeting to mitochondrion molecular_function mitochondrial nucleoid|mitochondrion
YBL057C YBL057C PTH2 hom Verified 0.342570944972924 0.365960631682443 no 1667 0.38471203432411 1286 NA FT PROTEOLYSIS MITOCHONDRION One of two (see also PTH1) mitochondrially-localized peptidyl-tRNA hydrolases; negatively regulates the ubiquitin-proteasome pathway via interactions with ubiquitin-like ubiquitin-associated proteins; dispensable for cell growth negative regulation of proteasomal ubiquitin-dependent protein catabolic process aminoacyl-tRNA hydrolase activity mitochondrial outer membrane|mitochondrion|cytoplasm
YNL068C YNL068C FKH2 hom Verified 0.341825203769249 0.36624122049954 no 1668 0.357636488980111 1192 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|MITOCHONDRION ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Forkhead family transcription factor; plays a major role in the expression of G2/M phase genes; positively regulates transcriptional elongation; negative role in chromatin silencing at HML and HMR; substrate of the Cdc28p/Clb5p kinase; FKH2 has a paralog, FKH1, that arose from the whole genome duplication negative regulation of chromatin silencing at silent mating-type cassette|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription involved in G2/M-phase of mitotic cell cycle|negative regulation of transcription involved in G1 phase of mitotic cell cycle|Unknown|chromatin remodeling|negative regulation of transcription involved in G2/M-phase of mitotic cell cycle RNA polymerase II transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II transcription factor binding transcription factor activity nucleus
YCR064C_d YCR064C YCR064C hom Dubious 0.341825049217936 0.366241278657655 no 1669 0.386238445697602 1294 NA FF Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31 Unknown Unknown Unknown
YDR338C_p YDR338C YDR338C hom Uncharacterized 0.34117648483573 0.36648536239246 no 1670 0.387501807861207 1304 NA Putative protein of unknown function, member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily transmembrane transport antiporter activity integral to membrane
YNL230C YNL230C ELA1 hom Verified 0.341129167102852 0.366503172283314 no 1671 0.37514144001075 1268 NA FT PROTEOLYSIS NUCLEUS UBIQUITIN LIGASE COMPLEX Elongin A; F-box protein that forms a heterodimer with Elc1p and is required for ubiquitin-dependent degradation of the RNA Polymerase II subunit Rpo21p; subunit of the Elongin-Cullin-Socs (ECS) ligase complex protein ubiquitination involved in ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity elongin complex|Cul3-RING ubiquitin ligase complex
YJL092W YJL092W SRS2 hom Verified 0.340699431792225 0.366664933235664 no 1672 0.375651955531651 1250 NA FT RESPONSE TO DNA DAMAGE NUCLEUS DNA helicase and DNA-dependent ATPase involved in DNA repair and checkpoint recovery, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability DNA repair|double-strand break repair via nonhomologous end joining|DNA duplex unwinding DNA helicase activity nucleus
YEL018W YEL018W EAF5 hom Verified 0.34058072838925 0.366709619742882 no 1673 0.380200860645348 1313 NA FT CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS HISTONE ACETYLTRANSFERASE Esa1p-associated factor, non-essential subunit of the NuA4 acetyltransferase complex DNA repair molecular_function nucleus|NuA4 histone acetyltransferase complex
YAL044C YAL044C GCV3 hom Verified 0.339916230418999 0.366959806773407 no 1674 0.390775496501121 1288 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5,10-methylene-THF glycine catabolic process|one-carbon metabolic process|protein lipoylation glycine dehydrogenase (decarboxylating) activity mitochondrion|glycine cleavage complex
YFR011C YFR011C AIM13 hom Verified 0.339353525355797 0.367171712428915 no 1675 0.35641680509928 1184 NA FT MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial protein peripheral to the inner membrane; component of the mitochondrial inner membrane organizing system (MINOS, MitOS, or MICOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture cristae formation molecular_function mitochondrion|extrinsic to mitochondrial inner membrane|mitochondrial crista junction|cytoplasm|mitochondrial intermembrane space
YER034W YER034W YER034W hom Verified 0.338640392949061 0.367440324731524 no 1676 0.376899622864893 1241 NA FT NUCLEUS Protein of unknown function; non-essential gene; expression induced upon calcium shortage; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus|cytoplasm
YGL070C YGL070C RPB9 hom Verified 0.338195220470203 0.367608038698952 no 1677 0.394018123406962 1313 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE NUCLEUS RNA POL II, HOLOENZYME RNA polymerase II subunit B12.6; contacts DNA; mutations affect transcription start site selection and fidelity of transcription transcription initiation from RNA polymerase II promoter|maintenance of transcriptional fidelity during DNA-dependent transcription elongation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|response to DNA damage stimulus|transcription from RNA polymerase II promoter RNA-directed RNA polymerase activity DNA-directed RNA polymerase II, core complex
YHL020C YHL020C OPI1 hom Verified 0.336987432600192 0.36806318696251 no 1678 0.380458276230727 1287 NA FT TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM|SIGNALING ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Transcriptional regulator of a variety of genes; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; involved in telomere maintenance endoplasmic reticulum unfolded protein response|negative regulation of transcription from RNA polymerase II promoter|phospholipid biosynthetic process|positive regulation of transcription from RNA polymerase II promoter transcription corepressor activity nuclear membrane|nucleoplasm|nuclear envelope|endoplasmic reticulum|nucleus
YGL031C YGL031C RPL24A hom Verified 0.336642932546957 0.368193043914304 no 1679 0.376058318198885 1262 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L24A; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24A has a paralog, RPL24B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YPL189C-A YPL189C-A COA2 hom Verified 0.334772744288434 0.368898261113187 no 1680 0.368719375342839 1220 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p mitochondrial respiratory chain complex IV assembly molecular_function mitochondrial matrix
YLR244C YLR244C MAP1 hom Verified 0.334763056044753 0.36890191554217 no 1681 0.377472307078764 1267 NA FT PROTEOLYSIS RIBOSOME Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p negative regulation of gene expression|protein initiator methionine removal involved in protein maturation metalloaminopeptidase activity|mRNA binding cytosolic ribosome
YJL106W YJL106W IME2 hom Verified 0.334208051721502 0.369111284295204 no 1682 0.362564187502055 1193 NA FT CELL CYCLE|PROTEIN PHOSPHORYLATION NUCLEUS Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p protein phosphorylation|regulation of meiosis protein kinase activity nucleus
YML034C-A_d YML034C-A YML034C-A hom Dubious 0.333186996487432 0.369496566599736 no 1683 0.391095089907181 1292 NA Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YCR083W YCR083W TRX3 hom Verified 0.333077480591455 0.369537898831662 no 1684 0.345945180733073 1175 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS MITOCHONDRION Mitochondrial thioredoxin, highly conserved oxidoreductase required to maintain the redox homeostasis of the cell, forms the mitochondrial thioredoxin system with Trr2p, redox state is maintained by both Trr2p and Glr1p cellular response to oxidative stress disulfide oxidoreductase activity mitochondrion
YML078W YML078W CPR3 hom Verified 0.331556150826487 0.370112217391556 no 1685 0.377955663145522 1253 NA FT MITOCHONDRION Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; involved in protein refolding after import into mitochondria protein folding|apoptotic process peptidyl-prolyl cis-trans isomerase activity mitochondrion
YEL040W YEL040W UTR2 hom Verified 0.331090506657696 0.370288061110642 no 1686 0.362394896912117 1215 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM SITE OF POLARIZED GROWTH|CYTOSKELETON Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck cell wall chitin metabolic process|fungal-type cell wall organization transferase activity, transferring glycosyl groups cellular bud neck septin ring|fungal-type cell wall
YDR182W-A_p YDR182W-A YDR182W-A hom Uncharacterized 0.331079566880775 0.370292192683706 no 1687 0.373467045689334 1227 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YBR048W YBR048W RPS11B hom Verified 0.330944985657789 0.370343020552769 no 1688 0.376365097022647 1236 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11B has a paralog, RPS11A, that arose from the whole genome duplication cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal small subunit assembly structural constituent of ribosome cytosolic small ribosomal subunit|90S preribosome
YOL124C YOL124C TRM11 hom Verified 0.330700390186066 0.370435403771736 no 1689 0.375986567423431 1229 NA FT RNA PROCESSING Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain tRNA methylation S-adenosylmethionine-dependent methyltransferase activity|RNA binding|tRNA (guanine-N2-)-methyltransferase activity cytoplasm|tRNA (m2G10) methyltransferase complex
YHR080C YHR080C YHR080C hom Verified 0.330122646241807 0.370653646164002 no 1690 0.377602263724218 1265 NA FT MITOCHONDRION Protein of unknown function; may interact with ribosomes, based on co-purification experiments; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YHR080C has a paralog, YSP2, that arose from the whole genome duplication biological_process molecular_function mitochondrion|ribosome
YPR147C_p YPR147C YPR147C hom Uncharacterized 0.330095806626315 0.370663785823345 no 1691 0.372904034123454 1255 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS biological_process molecular_function cytoplasm
YNL254C YNL254C RTC4 hom Verified 0.329905353207564 0.370735739239929 no 1692 0.347570862563123 1143 NA FT NUCLEUS Protein of unknown function; null mutation suppresses cdc13-1 temperature sensitivity; (GFP)-fusion protein localizes to both the cytoplasm and the nucleus biological_process molecular_function nucleus|cytoplasm
YCR065W YCR065W HCM1 hom Verified 0.329765805482897 0.370788463324635 no 1693 0.369476769428877 1270 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|RESPONSE TO OXIDATIVE STRESS NUCLEUS|CHROMOSOME Forkhead transcription factor that drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere maintenance role positive regulation of transcription involved in S-phase of mitotic cell cycle|cellular response to oxidative stress|mitochondrion organization|spindle pole body organization|positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding nuclear chromatin|nucleus|cytoplasm
YGR025W_d YGR025W YGR025W hom Dubious 0.327956880117142 0.371472132870748 no 1694 0.353279115069817 1201 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGR043C YGR043C NQM1 hom Verified 0.32762525958598 0.371597510385856 no 1695 0.36745899084069 1237 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS NUCLEUS Transaldolase of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift biological_process sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity nucleus
YOR233W YOR233W KIN4 hom Verified 0.327273170642634 0.37173064141058 no 1696 0.346617770422414 1172 NA FT CELL CYCLE|PROTEIN PHOSPHORYLATION SITE OF POLARIZED GROWTH|CYTOSKELETON Serine/threonine protein kinase; inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck; KIN4 has a paralog, FRK1, that arose from the whole genome duplication mitotic cell cycle spindle orientation checkpoint|protein phosphorylation protein serine/threonine kinase activity|protein kinase activity cell cortex|spindle pole body|cellular bud neck
YAL065C_p YAL065C YAL065C hom Uncharacterized 0.325169274245971 0.372526480877291 no 1697 0.357323483114479 1193 NA Putative protein of unknown function; has homology to FLO1; possible pseudogene biological_process molecular_function cellular_component
YPL159C YPL159C PET20 hom Verified 0.323893210504489 0.373009442193245 no 1698 0.378071689634674 1234 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Mitochondrial protein, required for respiratory growth under some conditions and for stability of the mitochondrial genome aerobic respiration molecular_function mitochondrion
YBR093C YBR093C PHO5 hom Verified 0.323539742247619 0.373143257289481 no 1699 0.368501503510643 1229 NA FT RESPONSE TO NUTRIENT LEVELS Repressible acid phosphatase (1 of 3) that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2 cellular response to phosphate starvation|phosphate-containing compound metabolic process|regulation of cell size nucleoside-triphosphate diphosphatase activity|nucleoside-triphosphatase activity|acid phosphatase activity fungal-type cell wall|cell wall-bounded periplasmic space
YNL300W_p YNL300W TOS6 hom Uncharacterized 0.323128974783437 0.373298783796557 no 1700 0.381565051089583 1284 NA Glycosylphosphatidylinositol-dependent cell wall protein, expression is periodic and decreases in respone to ergosterol perturbation or upon entry into stationary phase; depletion increases resistance to lactic acid biological_process molecular_function fungal-type cell wall
YDR310C YDR310C SUM1 hom Verified 0.322607094084323 0.373496410237896 no 1701 0.389639532183196 1288 NA FT TRANSCRIPTION FROM RNA POL II|GENE SILENCING NUCLEUS Transcriptional repressor required for mitotic repression of middle sporulation-specific genes; also acts as general replication initiation factor; involved in telomere maintenance, chromatin silencing; regulated by pachytene checkpoint negative regulation of transcription by competitive promoter binding|negative regulation of transcription from RNA polymerase II promoter during mitosis|DNA replication initiation|chromatin silencing at silent mating-type cassette DNA replication origin binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding nucleus
YNL177C YNL177C MRPL22 hom Verified 0.322451259199141 0.373555428442528 no 1702 0.383485510047941 1271 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YDR497C YDR497C ITR1 hom Verified 0.322171402275393 0.373661424049847 no 1703 0.364215669330808 1198 NA FT PLASMA MEMBRANE Myo-inositol transporter; has strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p; relative distribution to the vacuole increases upon DNA replication stress myo-inositol transport|transmembrane transport myo-inositol transmembrane transporter activity integral to membrane|plasma membrane|membrane
YHR035W_p YHR035W YHR035W hom Uncharacterized 0.321803188956983 0.373800899136119 no 1704 0.341315898488691 1167 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM Putative protein of unknown function; not an essential gene biological_process molecular_function cellular_component
YPL176C YPL176C TRE1 hom Verified 0.320873700002295 0.374153052636295 no 1705 0.370519904611398 1240 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT PLASMA MEMBRANE Transferrin receptor-like protein; plasma membrane protein that binds Bsd2p and regulates ubiquitylation and vacuolar degradation of the metal transporter Smf1p; functionally redundant with Tre2p; TRE1 has a paralog, TRE2, that arose from the whole genome duplication protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway molecular_function fungal-type vacuole
YKL090W YKL090W CUE2 hom Verified 0.320386150553059 0.37433781147554 no 1706 0.366310321455479 1191 NA Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination biological_process ubiquitin binding cellular_component
YKL190W YKL190W CNB1 hom Verified 0.320366198768093 0.37434537290029 no 1707 0.373729778691646 1245 NA FF|FT SIGNALING|ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1; protein abundance increases in response to DNA replication stress adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|fungal-type cell wall organization|cellular ion homeostasis calcium-dependent protein serine/threonine phosphatase activity|calcium ion binding calcineurin complex
YBR072C-A_p YBR072C-A YBR072C-A hom Uncharacterized 0.320365451466755 0.374345656117134 no 1708 0.373309606285366 1228 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YKR099W YKR099W BAS1 hom Verified 0.319557642882188 0.374651843989863 no 1709 0.379051503819479 1186 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes positive regulation of transcription from RNA polymerase II promoter core promoter sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|RNA polymerase II transcription factor recruiting transcription factor activity nucleus
YML001W YML001W YPT7 hom Verified 0.319020181474463 0.374855604576374 no 1710 0.364354911120554 1195 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|VACUOLAR TRANSPORT MITOCHONDRION Rab family GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion; interacts with the cargo selection/retromer complex for retrograde sorting; similar to mammalian Rab7 regulation of vacuole fusion, non-autophagic|piecemeal microautophagy of nucleus|vacuole inheritance|Golgi to vacuole transport|vesicle-mediated transport|endocytosis GTPase activity mitochondrial outer membrane|fungal-type vacuole
YER107C YER107C GLE2 hom Verified 0.317910697040174 0.375276339085666 no 1711 0.410837825455809 1355 NA FF|FT PROTEIN LOCALIZATION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE RNA export factor associated with the nuclear pore complex (NPC); associates with NUP116p; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p and human RAE1 poly(A)+ mRNA export from nucleus|Unknown|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|nuclear pore distribution|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery molecular_function integral to membrane|nuclear pore|cytoplasm
YDR101C YDR101C ARX1 hom Verified 0.316337802863515 0.375873060346788 no 1712 0.386515492543964 1271 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|PROTEOLYSIS NUCLEUS RIBOSOME Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex ribosomal large subunit biogenesis molecular_function nucleoplasm|cytosolic large ribosomal subunit|cytoplasm
YDR482C YDR482C CWC21 hom Verified 0.315815675812297 0.376071209521647 no 1713 0.386615653418942 1282 NA FT RNA PROCESSING NUCLEUS Protein involved in RNA splicing by the spliceosome; component of a complex containing Cef1p; interacts genetically with ISY1 and BUD13; may bind RNA; has similarity to S. pombe Cwf21p mRNA splicing, via spliceosome molecular_function U2-type spliceosomal complex
YMR192W YMR192W GYL1 hom Verified 0.31462257859848 0.37652411695804 no 1714 0.370230811863466 1214 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM MITOCHONDRION|GOLGI APPARATUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Putative GTPase activating protein (GAP) with a role in exocytosis; stimulates Gyp5p GAP activity on Ypt1p, colocalizes with Gyp5p at sites of polarized growth; interacts with Gyp5p, Rvs161p, and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; increases in abundance and relocalizes from bud neck to cytoplasm upon DNA replication stress ER to Golgi vesicle-mediated transport|regulation of exocytosis protein binding mitochondrion|incipient cellular bud site|cellular bud|cellular bud neck|cellular bud tip|cytoplasm|Golgi-associated vesicle|plasma membrane
YGR284C YGR284C ERV29 hom Verified 0.313178312148136 0.377072597315925 no 1715 0.381314564530514 1259 NA FT VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein localized to COPII-coated vesicles; involved in vesicle formation and incorporation of specific secretory cargo; protein abundance increases in response to DNA replication stress ER to Golgi vesicle-mediated transport molecular_function integral to membrane|ER to Golgi transport vesicle
YNL127W YNL127W FAR11 hom Verified 0.310987382286265 0.377905106922871 no 1716 0.428183325285269 1428 NA FT CELL CYCLE|SIGNALING Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far10p; has similarity to the N- and C-termini of N. crassa HAM-2 re-entry into mitotic cell cycle after pheromone arrest molecular_function cellular_component
YPL120W YPL120W VPS30 hom Verified 0.310438737490948 0.378113669970391 no 1717 0.377878902275838 1277 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy and Complex II is required for vacuolar protein sorting; required for overflow degradation of misfolded proteins when ERAD is saturated; ortholog of the higher eukaryotic gene Beclin 1 phosphatidylinositol biosynthetic process|piecemeal microautophagy of nucleus|ER-associated protein catabolic process|peroxisome degradation|retrograde transport, endosome to Golgi|macroautophagy|CVT pathway|late endosome to vacuole transport 1-phosphatidylinositol-3-kinase activity phosphatidylinositol 3-kinase complex I|phosphatidylinositol 3-kinase complex II|extrinsic to membrane|cytoplasm
YGR249W YGR249W MGA1 hom Verified 0.310230407959931 0.378192874128707 no 1718 0.37863402654309 1281 NA FT NUCLEUS Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants filamentous growth sequence-specific DNA binding|DNA binding|sequence-specific DNA binding transcription factor activity nucleus
YJL013C YJL013C MAD3 hom Verified 0.309538233413824 0.378456066564781 no 1719 0.365654229698983 1215 NA FT CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION NUCLEUS Subunit of the spindle-assembly checkpoint complex, which delays anaphase onset in cells with defects in mitotic spindle assembly; pseudosubstrate inhibitor of APC(Cdc20), the anaphase promoting complex involved in securin (Pds1p) turnover distributive segregation|mitotic cell cycle spindle assembly checkpoint|mitotic cell cycle G2/M transition decatenation checkpoint molecular_function mitotic checkpoint complex
YBR199W YBR199W KTR4 hom Verified 0.309049221137733 0.378642042585876 no 1720 0.349603066410038 1182 NA FT CARBOHYDRATE METABOLISM GOLGI APPARATUS Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family protein N-linked glycosylation mannosyltransferase activity Golgi apparatus
YGL015C_p YGL015C YGL015C hom Uncharacterized 0.308970739348606 0.378671892575578 no 1721 0.3685954228588 1209 NA Putative protein of unknown function; null mutants accumulate cargo in the Golgi biological_process molecular_function cellular_component
YLL006W-A_p YLL006W-A YLL006W-A hom Uncharacterized 0.308537946287019 0.378836515332333 no 1722 0.36720757762173 1183 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YOR178C YOR178C GAC1 hom Verified 0.308022500128613 0.379032605768413 no 1723 0.382222194962222 1255 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock meiosis|glycogen metabolic process|negative regulation of transcription from RNA polymerase II promoter|response to heat|mitotic cell cycle spindle assembly checkpoint protein phosphatase type 1 regulator activity|structural molecule activity|heat shock protein binding protein phosphatase type 1 complex
YJL007C_d YJL007C YJL007C hom Dubious 0.307866457856608 0.379091974845897 no 1724 0.380077232049153 1267 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YKL084W YKL084W HOT13 hom Verified 0.304363756239534 0.380425388532311 no 1725 0.376309117091579 1272 NA FT PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Zinc-binding mitochondrial intermembrane space (IMS) protein involved in a disulfide relay system for IMS import of cysteine-containing proteins; binds Mia40p and stimulates its Erv1p-dependent oxidation, probably by sequestering zinc protein import into mitochondrial intermembrane space zinc ion binding mitochondrial intermembrane space
YLR285W YLR285W NNT1 hom Verified 0.304329791222869 0.380438325372382 no 1726 0.370157075944497 1221 NA FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|GENE SILENCING S-adenosylmethionine-dependent methyltransferase; has a role in rDNA silencing and in lifespan determination chromatin silencing at rDNA|nicotinamide metabolic process S-adenosylmethionine-dependent methyltransferase activity|nicotinamide N-methyltransferase activity cytoplasm
YDL155W YDL155W CLB3 hom Verified 0.303749493823935 0.380659373871586 no 1727 0.382815061222523 1262 NA FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION NUCLEUS B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress G2/M transition of mitotic cell cycle|S phase of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|positive regulation of spindle pole body separation cyclin-dependent protein kinase regulator activity nucleus|cytoplasm
YKL162C_p YKL162C YKL162C hom Uncharacterized 0.303331096296989 0.380818775201059 no 1728 0.36714122887049 1227 NA FT MITOCHONDRION Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion biological_process molecular_function mitochondrion
YMR088C YMR088C VBA1 hom Verified 0.303221051411235 0.380860703526054 no 1729 0.381213563940286 1269 NA Permease of basic amino acids in the vacuolar membrane basic amino acid transport basic amino acid transmembrane transporter activity fungal-type vacuole membrane|integral to membrane
YLL009C YLL009C COX17 hom Verified 0.30271183370502 0.381054739342526 no 1730 0.374912029019514 1219 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS MITOCHONDRION Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs mitochondrial respiratory chain complex IV assembly|intracellular copper ion transport copper chaperone activity cytosol|mitochondrion|mitochondrial intermembrane space
YJL115W YJL115W ASF1 hom Verified 0.301884178753278 0.381370178475569 no 1731 0.343233041770471 1156 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition DNA replication-independent nucleosome assembly|histone acetylation|nucleosome disassembly|histone exchange|positive regulation of histone acetylation|chromatin silencing at silent mating-type cassette|chromatin silencing at telomere|DNA replication-dependent nucleosome assembly|regulation of transcription from RNA polymerase II promoter in response to stress histone binding chromatin assembly complex
YLR122C_d YLR122C YLR122C hom Dubious 0.300227010160909 0.382002001850511 no 1732 0.392824009561091 1261 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C Unknown Unknown Unknown
YER109C YER109C FLO8 hom Verified 0.298009022827296 0.382848138561472 no 1733 0.373036847529971 1236 NA FT TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM NUCLEUS Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this gene biofilm formation|Unknown|positive regulation of starch catabolic process by positive regulation of transcription from RNA polymerase II promoter|positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus|cytoplasm
YML087C YML087C AIM33 hom Verified 0.29659054917232 0.383389563527861 no 1734 0.376720279534716 1204 NA FT OXIDATION-REDUCTION PROCESS Putative protein of unknown function, highly conserved across species; homolog of human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss; AIM33 has a paralog, PGA3, that arose from the whole genome duplication biological_process molecular_function cellular_component
YHL031C YHL031C GOS1 hom Verified 0.296085800755988 0.383582278721772 no 1735 0.456873291921864 1529 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|GOLGI APPARATUS v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28 Golgi vesicle transport|vesicle fusion SNAP receptor activity SNARE complex|integral to membrane|Golgi medial cisterna
YBL027W YBL027W RPL19B hom Verified 0.295714190087114 0.383724179742165 no 1736 0.361839772030862 1209 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L19B; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19B has a paralog, RPL19A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YHR147C YHR147C MRPL6 hom Verified 0.294448052929549 0.384207776254979 no 1737 0.398842121714865 1308 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YOR150W YOR150W MRPL23 hom Verified 0.293556866194539 0.384548269980475 no 1738 0.420514478046945 1388 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YMR175W YMR175W SIP18 hom Verified 0.293484316112035 0.38457599295333 no 1739 0.370066980770663 1231 NA Phospholipid-binding hydrophilin; essential to overcome desiccation-rehydration process; expression is induced by osmotic stress cellular response to water deprivation phospholipid binding cytoplasm
YJR053W YJR053W BFA1 hom Verified 0.293470501284989 0.384581271967717 no 1740 0.365195798401675 1196 NA FT CELL CYCLE|CELL DIVISION CYTOSKELETON Component of the GTPase-activating Bfa1p-Bub2p complex involved in multiple cell cycle checkpoint pathways that control exit from mitosis regulation of exit from mitosis|mitotic cell cycle spindle orientation checkpoint GTPase activator activity spindle pole body
YDR036C YDR036C EHD3 hom Verified 0.291804740242442 0.385217960358305 no 1741 0.379681056631954 1246 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION 3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis fatty acid beta-oxidation|biological_process 3-hydroxyisobutyryl-CoA hydrolase activity mitochondrion
YLR031W_p YLR031W YLR031W hom Uncharacterized 0.291525362374305 0.385324774725771 no 1742 0.397164047209525 1297 NA Putative protein of unknown function biological_process molecular_function cellular_component
YER064C YER064C VHR2 hom Verified 0.291330097636446 0.385399435337897 no 1743 0.373647352000458 1234 NA FT NUCLEUS Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress regulation of transcription, DNA-dependent molecular_function nucleus
YER071C_p YER071C TDA2 hom Uncharacterized 0.291295360039899 0.385412717905755 no 1744 0.387379930090344 1259 NA FT SITE OF POLARIZED GROWTH Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele biological_process molecular_function mating projection tip|cytoplasm
YMR238W YMR238W DFG5 hom Verified 0.290320585243484 0.385785495976644 no 1745 0.40713377214633 1381 NA FT CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM PLASMA MEMBRANE Putative mannosidase, essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis in bud formation, involved in filamentous growth, homologous to Dcw1p pseudohyphal growth|fungal-type cell wall biogenesis|budding cell bud growth mannosidase activity anchored to plasma membrane
YJL070C_p YJL070C YJL070C hom Uncharacterized 0.290250749033395 0.385812207130532 no 1746 0.344650841964625 1137 NA FT NUCLEOTIDE METABOLISM MITOCHONDRION Putative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic defect of quadruple aah1 ade8 amd1 his1 mutant; may regulate purine nucleotide homeostasis as overexpression in an AMD1 strain grown in adenine results in greatly reduced GDP and GTP intracellular levels; not an essential gene; YJL070C has a paralog, YBR284W, that arose from the whole genome duplication biological_process AMP deaminase activity|molecular_function mitochondrion|cytoplasm
YOR071C YOR071C NRT1 hom Verified 0.290200764977179 0.385831325508134 no 1747 0.377253132980563 1248 NA FT PLASMA MEMBRANE High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity thiamine transport|nicotinamide riboside transport nicotinamide riboside transporter activity integral to membrane|plasma membrane
YHL023C YHL023C NPR3 hom Verified 0.290135136244276 0.38585642823169 no 1748 0.40405918836469 1337 NA FT CELL CYCLE|SIGNALING|RESPONSE TO NUTRIENT LEVELS Subunit of SEA (Seh1-associated), Npr2/3, and Iml1p complexes; Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation; SEA complex is a coatomer-related complex that associates dynamically with the vacuole; Iml1p complex (Iml1p-Npr2p-Npr3p) is required for non-nitrogen-starvation (NNS)-induced autophagy; required for Npr2p phosphorylation and Iml1p-Npr2p interaction; null mutant shows delayed meiotic DNA replication and double-strand break repair meiosis|regulation of TOR signaling cascade|cellular response to amino acid starvation molecular_function Seh1-associated complex|extrinsic to fungal-type vacuolar membrane
YOR125C YOR125C CAT5 hom Verified 0.289491583552895 0.386102609829328 no 1749 0.381185109520805 1271 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|COFACTOR METABOLISM MITOCHONDRION Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation ubiquinone biosynthetic process monooxygenase activity mitochondrion|mitochondrial inner membrane
YCL026C-B YCL026C-B HBN1 hom Verified 0.288928582795956 0.386318015090855 no 1750 0.393501255221157 1329 NA FT OXIDATION-REDUCTION PROCESS NUCLEUS Protein of unknown function; similar to bacterial nitroreductases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein becomes insoluble upon intracellular iron depletion; protein abundance increases in response to DNA replication stress biological_process NAD(P)H nitroreductase activity nucleus|cytoplasm
YGL237C YGL237C HAP2 hom Verified 0.288799543343116 0.386367390792629 no 1751 0.380972640438539 1260 NA FT TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding carbon catabolite activation of transcription from RNA polymerase II promoter|regulation of cellular respiration RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription CCAAT-binding factor complex|nucleus
YMR025W YMR025W CSI1 hom Verified 0.288694728878959 0.38640749839057 no 1752 0.373476703840725 1245 NA FT SIGNALING NUCLEUS Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling; functional equivalent of canonical Csn6 subunit of the COP9 signalosome adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|cullin deneddylation molecular_function signalosome
YDL035C YDL035C GPR1 hom Verified 0.287912707190306 0.386706779830556 no 1753 0.400783465204477 1329 NA FT SIGNALING PLASMA MEMBRANE Plasma membrane G protein coupled receptor (GPCR) that interacts with the heterotrimeric G protein alpha subunit, Gpa2p, and with Plc1p; sensor that integrates nutritional signals with the modulation of cell fate via PKA and cAMP synthesis replicative cell aging|G-protein coupled receptor signaling pathway|sucrose mediated signaling|glucose mediated signaling pathway|pseudohyphal growth|hexose mediated signaling|invasive growth in response to glucose limitation|detection of glucose|detection of sucrose stimulus G-protein coupled receptor activity|glucose binding integral to membrane|plasma membrane
YOR268C_p YOR268C YOR268C hom Uncharacterized 0.287759353841284 0.386765476407167 no 1754 0.358071147280444 1181 NA Putative protein of unknown function; sporulation is abnormal in homozygous diploid; YOR268C is not an essential gene biological_process molecular_function cellular_component
YMR056C YMR056C AAC1 hom Verified 0.287163710106067 0.386993485866338 no 1755 0.378739742174987 1247 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator; relocalizes from mitochondrion to cytoplasm upon DNA replication stress heme biosynthetic process|mitochondrial transport|heme transport|aerobic respiration ATP:ADP antiporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YOR082C_d YOR082C YOR082C hom Dubious 0.286766955475794 0.387145383212654 no 1756 0.386843703594038 1252 NA Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene YOR083W Unknown Unknown Unknown
YGR018C_p YGR018C YGR018C hom Uncharacterized 0.28658310777035 0.387215775091957 no 1757 0.377149703833068 1243 NA Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the uncharacterized ORF YGR017W biological_process molecular_function cellular_component
YGR212W YGR212W SLI1 hom Verified 0.286534945313599 0.38723421621725 no 1758 0.397803795143934 1329 NA FT ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin response to drug N-acetyltransferase activity nuclear envelope|plasma membrane
YDR171W YDR171W HSP42 hom Verified 0.286452239024615 0.38726588456924 no 1759 0.372289365757185 1236 NA FT CYTOSKELETON ORGANIZATION CYTOSKELETON Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress cytoskeleton organization unfolded protein binding cytoskeleton|chaperonin-containing T-complex|cytoplasm
YOL055C YOL055C THI20 hom Verified 0.286240695139992 0.387346888427368 no 1760 0.378399342331218 1281 NA Trifunctional enzyme of thiamine biosynthesis, degradation and salvage; has hydroxymethylpyrimidine (HMP) kinase, HMP-phosphate (HMP-P) kinase and thiaminase activities; member of a gene family with THI21 and THI22; HMP and HMP-P kinase activity redundant with Thi21p thiamine biosynthetic process|thiamine catabolic process phosphomethylpyrimidine kinase activity|thiaminase activity|hydroxymethylpyrimidine kinase activity cytosol
YHR017W YHR017W YSC83 hom Verified 0.286213815850455 0.387357181329356 no 1761 0.40113063639419 1312 NA FT MITOCHONDRION Non-essential mitochondrial protein of unknown function; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83 biological_process molecular_function mitochondrial outer membrane|mitochondrion
YMR311C YMR311C GLC8 hom Verified 0.2860728511823 0.3874111623082 no 1762 0.397513447733639 1318 NA FT SIGNALING|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|CHROMOSOME SEGREGATION NUCLEUS Regulatory subunit of protein phosphatase 1 (Glc7p); involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2; protein abundance increases in response to DNA replication stress chromosome segregation|glycogen biosynthetic process enzyme activator activity nucleus|cytoplasm
YJL196C YJL196C ELO1 hom Verified 0.28456132874897 0.387990120990346 no 1763 0.375520188082883 1232 NA FT KETONE METABOLISM|LIPID METABOLISM Elongase I, medium-chain acyl elongase; catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids; ELO1 has a paralog, FEN1, that arose from the whole genome duplication fatty acid elongation, unsaturated fatty acid fatty acid elongase activity integral to membrane|membrane
YOR045W YOR045W TOM6 hom Verified 0.283384300614252 0.388441130824604 no 1764 0.38942680217466 1300 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex mitochondrial outer membrane translocase complex assembly|protein import into mitochondrial matrix protein channel activity mitochondrion|integral to membrane|mitochondrial outer membrane translocase complex
YLL043W YLL043W FPS1 hom Verified 0.282643183847515 0.388725186781314 no 1765 0.381274046222353 1253 NA FT ION HOMEOSTASIS|CARBOHYDRATE METABOLISM|ION HOMEOSTASIS PLASMA MEMBRANE Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress conjugation with cellular fusion|transport|arsenite transport|glycerol transport|acetate transport|response to arsenic-containing substance glycerol transmembrane transporter activity|transporter activity integral to membrane|plasma membrane|fungal-type vacuole|cytoplasm
YOL147C YOL147C PEX11 hom Verified 0.282228757250945 0.388884054562478 no 1766 0.37941377595035 1231 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|PEROXISOME ORGANIZATION ENDOPLASMIC RETICULUM Peroxisomal membrane protein required for medium-chain fatty acid oxidation and peroxisome proliferation, possibly by inducing membrane curvature; localization regulated by phosphorylation; transcription regulated by Adr1p and Pip2p-Oaf1p peroxisome fission|fatty acid oxidation molecular_function endoplasmic reticulum|peroxisomal membrane
YJL205C YJL205C NCE101 hom Verified 0.281733491991512 0.389073935698546 no 1767 0.364859816286064 1248 NA FT PROTEIN LOCALIZATION Protein of unknown function, involved in secretion of proteins that lack classical secretory signal sequences protein secretion molecular_function cellular_component
YBL075C YBL075C SSA3 hom Verified 0.281539635042562 0.389148266275363 no 1768 0.397742515864077 1318 NA FT PROTEIN LOCALIZATION ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm; SSA3 has a paralog, SSA4, that arose from the whole genome duplication protein folding|SRP-dependent cotranslational protein targeting to membrane, translocation|response to stress unfolded protein binding|ATPase activity cytosol
YKL188C YKL188C PXA2 hom Verified 0.28120776619268 0.389275524176285 no 1769 0.381395560939055 1250 NA FT NUCLEOTIDE METABOLISM Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter ABCD1 and ABCD2 and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder fatty acid transport ATPase activity, coupled to transmembrane movement of substances integral to membrane|integral to peroxisomal membrane
YKL091C YKL091C YKL091C hom Verified 0.28097863731915 0.389363392500884 no 1770 0.39418768029957 1309 NA FT NUCLEUS Putative homolog of Sec14p, which is a phosphatidylinositol/phosphatidylcholine transfer protein involved in lipid metabolism; localizes to the nucleus; contains a CRAL/TRIO domain and binds several lipids in a large-scale study biological_process phosphatidylcholine binding|phosphatidylinositol transporter activity|phosphatidylinositol binding|phosphatidylcholine transporter activity nucleus
YAL053W YAL053W FLC2 hom Verified 0.280738192718232 0.389455606361685 no 1771 0.40226976734855 1352 NA FT CELL WALL ORG/BIOGENESIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication protein folding|fungal-type cell wall biogenesis|FAD transport|transmembrane transport FAD transmembrane transporter activity integral to membrane|endoplasmic reticulum|cytoplasm
YOR247W YOR247W SRL1 hom Verified 0.280304593103659 0.389621913597333 no 1772 0.391219927527402 1275 NA FT CELL WALL ORG/BIOGENESIS SITE OF POLARIZED GROWTH Mannoprotein that exhibits a tight association with the cell wall; required for cell wall stability in the absence of GPI-anchored mannoproteins; has a high serine-threonine content; expression is induced in cell wall mutants; SRL1 has a paralog, SVS1, that arose from the whole genome duplication fungal-type cell wall organization|nucleobase-containing compound metabolic process molecular_function fungal-type cell wall|fungal-type vacuole|cytoplasm|cellular bud tip
YJR103W YJR103W URA8 hom Verified 0.280203894372544 0.389660539513128 no 1773 0.371665101503199 1217 NA FT KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM Minor CTP synthase isozyme (see also URA7); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA8 has a paralog, URA7, that arose from the whole genome duplication pyrimidine nucleobase biosynthetic process|CTP biosynthetic process|phospholipid biosynthetic process CTP synthase activity cytosol
YJL183W YJL183W MNN11 hom Verified 0.27940518565093 0.389966945959775 no 1774 0.405724739304055 1343 NA FT CARBOHYDRATE METABOLISM GOLGI APPARATUS Subunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p protein glycosylation alpha-1,6-mannosyltransferase activity alpha-1,6-mannosyltransferase complex
YNL200C YNL200C YNL200C hom Verified 0.279038850857544 0.390107504863599 no 1775 0.379470306242715 1226 NA FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM MITOCHONDRION NADHX epimerase; catalyzes isomerization of (R)- and (S)-NADHX; homologous to AIBP in mammals and the N- terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies nicotinamide nucleotide metabolic process NADHX epimerase activity mitochondrion|cytoplasm
YJL120W_d YJL120W YJL120W hom Dubious 0.277669330042755 0.390633103084502 no 1776 0.430675889932627 1413 NA FF Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL121C/RPE1; deletion confers sensitivity to GSAO Unknown Unknown Unknown
YAL056W YAL056W GPB2 hom Verified 0.277019694800178 0.390882491729116 no 1777 0.390166263221276 1293 NA FT TRANSCRIPTION FROM RNA POL II|SIGNALING MITOCHONDRION|PLASMA MEMBRANE Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; GPB2 has a paralog, GPB1, that arose from the whole genome duplication signal transduction|glucose mediated signaling pathway|pseudohyphal growth|ascospore formation|negative regulation of Ras protein signal transduction|invasive growth in response to glucose limitation|positive regulation of transcription from RNA polymerase II promoter cAMP-dependent protein kinase inhibitor activity|signal transducer activity|GTPase activating protein binding mitochondrion|plasma membrane|cytoplasm
YBR171W YBR171W SEC66 hom Verified 0.276771536081541 0.390977769298021 no 1778 0.499221186020649 1671 NA FF|FT PROTEIN LOCALIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER posttranslational protein targeting to membrane, translocation|filamentous growth protein transporter activity integral to membrane|Sec62/Sec63 complex|endoplasmic reticulum membrane
YCL064C YCL064C CHA1 hom Verified 0.27676619303233 0.390979820769783 no 1779 0.393089877914621 1290 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine threonine catabolic process|L-serine catabolic process L-threonine ammonia-lyase activity|L-serine ammonia-lyase activity mitochondrial nucleoid|mitochondrion
YJL209W YJL209W CBP1 hom Verified 0.276481275513086 0.391089219671491 no 1780 0.380323301626709 1237 NA FT RNA PROCESSING|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Mitochondrial protein, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex at the inner membrane along with Pet309p; localizes to mitochondrial foci upon DNA replication stress mitochondrial mRNA catabolic process|aerobic respiration mRNA binding mitochondrion|extrinsic to mitochondrial inner membrane
YHR182W YHR182W YHR182W hom Verified 0.27619200690575 0.391200298063631 no 1781 0.408337022799454 1351 NA FT SIGNALING Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm; relocalizes from bud neck to cytoplasm upon DNA replication stress biological_process molecular_function cytoplasm
YPL214C YPL214C THI6 hom Verified 0.276148410523685 0.391217039730622 no 1782 0.355649712153714 1182 NA Bifunctional enzyme with thiamine-phosphate pyrophosphorylase and 4-methyl-5-beta-hydroxyethylthiazole kinase activities, required for thiamine biosynthesis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern thiamine biosynthetic process hydroxyethylthiazole kinase activity|thiamine-phosphate diphosphorylase activity cytosol|cytoplasm
YDR444W_p YDR444W YDR444W hom Uncharacterized 0.275173281400158 0.391591556610783 no 1783 0.393762909755931 1300 NA FT LIPID METABOLISM Putative hydrolase acting on ester bonds biological_process molecular_function cytoplasm
YDL223C YDL223C HBT1 hom Verified 0.274792337420313 0.391737892708943 no 1784 0.414613813014977 1380 NA Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis cell morphogenesis involved in conjugation with cellular fusion molecular_function plasma membrane|mating projection
YOL100W YOL100W PKH2 hom Verified 0.273370300486932 0.392284290183914 no 1785 0.380725308053342 1242 NA FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION NUCLEUS Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh1p regulation of nuclear-transcribed mRNA poly(A) tail shortening|protein phosphorylation|MAPK cascade involved in cell wall biogenesis|cytoplasmic mRNA processing body assembly protein kinase activity cell cortex|eisosome|nucleus
YGR209C YGR209C TRX2 hom Verified 0.273340740706229 0.39229565036693 no 1786 0.377159659382071 1259 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p; required for ER-Golgi transport and vacuole inheritance; protein abundance increases in response to DNA replication stress vacuole inheritance|regulation of DNA replication|cell redox homeostasis|protein deglutathionylation|sulfate assimilation|retrograde vesicle-mediated transport, Golgi to ER|cellular response to oxidative stress|ER to Golgi vesicle-mediated transport|vacuole fusion, non-autophagic disulfide oxidoreductase activity cytosol|fungal-type vacuole
YPL123C YPL123C RNY1 hom Verified 0.273086751863029 0.392393265148296 no 1787 0.380828864590944 1275 NA Vacuolar RNase of the T(2) family, relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; promotes apoptosis under stress conditions and this function is independent of its catalytic activity cell morphogenesis|RNA catabolic process|apoptotic process endoribonuclease activity cytosol|extracellular region|vacuole
YDL036C YDL036C PUS9 hom Verified 0.272863302581298 0.392479148349107 no 1788 0.380474695356245 1244 NA FT RNA PROCESSING NUCLEUS|MITOCHONDRION Mitochondrial tRNA:pseudouridine synthase, catalyzes the formation of pseudouridine at position 32 in mitochondrial tRNAs; contains an N-terminal mitochondrial targeting sequence tRNA pseudouridine synthesis pseudouridine synthase activity mitochondrion|nucleus|cytoplasm
YDL079C YDL079C MRK1 hom Verified 0.272104792137343 0.392770722466192 no 1789 0.390552170977694 1284 NA FT PROTEIN PHOSPHORYLATION Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation regulation of protein catabolic process|protein phosphorylation|response to stress protein serine/threonine kinase activity cellular_component
YPL141C YPL141C FRK1 hom Verified 0.272080848214299 0.39277992757626 no 1790 0.394489806042869 1307 NA FT PROTEIN PHOSPHORYLATION Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; interacts with rRNA transcription and ribosome biogenesis factors and the long chain fatty acyl-CoA synthetase Faa3p; FRK1 has a paralog, KIN4, that arose from the whole genome duplication protein phosphorylation protein kinase activity cytoplasm
YDL118W_d YDL118W YDL118W hom Dubious 0.272053489403751 0.392790445594531 no 1791 0.410881623073362 1365 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS Dubious open reading frame, unlikely to encode a protein; overlaps almost completely with YDL119C; mutations that would affect both YDL118W and YDL119C confer defective telomere maintenance and are synthetically sick or lethal with alpha-synuclein biological_process molecular_function cellular_component
YOR022C_p YOR022C YOR022C hom Uncharacterized 0.270794132035047 0.393274686638788 no 1792 0.38696269819393 1268 NA FT LIPID METABOLISM MITOCHONDRION Putative carboxylic ester hydrolase; similar to bovine phospholipase A1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process phospholipase activity mitochondrion
YDR140W YDR140W MTQ2 hom Verified 0.270193177064599 0.39350582073649 no 1793 0.382851911570582 1283 NA FT TRANSLATION NUCLEUS S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC peptidyl-glutamine methylation|regulation of translation protein methyltransferase activity|S-adenosylmethionine-dependent methyltransferase activity eRF1 methyltransferase complex|nucleus|cytoplasm
YBL051C YBL051C PIN4 hom Verified 0.268747324452653 0.394062065682382 no 1794 0.401186456785514 1356 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage G2/M transition of mitotic cell cycle|DNA damage checkpoint molecular_function cytoplasm
YNL160W YNL160W YGP1 hom Verified 0.267144787866205 0.39467884225683 no 1795 0.398461367789933 1327 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p cell wall assembly molecular_function extracellular region
YMR137C YMR137C PSO2 hom Verified 0.265803793675369 0.395195160680183 no 1796 0.385167104817585 1273 NA FT RESPONSE TO DNA DAMAGE NUCLEUS Nuclease required for DNA single- and double-strand break repair; acts at a post-incision step in repair of breaks that result from interstrand cross-links produced by a variety of mono- and bi-functional psoralen derivatives; induced by UV-irradiation; forms nuclear foci upon DNA replication stress DNA repair|double-strand break repair damaged DNA binding|5'-3' exonuclease activity nucleus
YOR133W YOR133W EFT1 hom Verified 0.265409752412338 0.395346912073895 no 1797 0.401012013451048 1325 NA FT TRANSLATION|NUCLEOTIDE METABOLISM RIBOSOME Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication translational elongation translation elongation factor activity ribosome
YNL059C YNL059C ARP5 hom Verified 0.26510009005681 0.395466178981747 no 1798 0.411938418721692 1373 NA FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes nucleosome mobilization|chromatin remodeling ATP-dependent 3'-5' DNA helicase activity nucleus|Ino80 complex
YDR066C YDR066C RTR2 hom Verified 0.264821349542907 0.395573544670947 no 1799 0.399924552540927 1313 NA FT NUCLEUS Protein of unknown function; exhibits genetic interactions with Rtr1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDR066C is not an essential gene; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; RTR2 has a paralog, RTR1, that arose from the whole genome duplication biological_process molecular_function cytoplasm
YJL093C YJL093C TOK1 hom Verified 0.263481597438439 0.396089702854572 no 1800 0.399866970253239 1308 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Outward-rectifier potassium channel of the plasma membrane with two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin cellular potassium ion homeostasis potassium channel activity integral to membrane|plasma membrane
YBL085W YBL085W BOI1 hom Verified 0.263398355792022 0.396121778881819 no 1801 0.399573719980854 1307 NA FT SIGNALING|CELL DIVISION SITE OF POLARIZED GROWTH Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication cytokinesis, completion of separation|establishment of cell polarity|budding cell apical bud growth|Rho protein signal transduction phospholipid binding site of polarized growth|cellular bud|mating projection tip|cellular bud neck
YER026C YER026C CHO1 hom Verified 0.263290735736576 0.396163249837152 no 1802 0.407969481433668 1345 NA FT LIPID METABOLISM ENDOPLASMIC RETICULUM|MITOCHONDRION Phosphatidylserine synthase, functions in phospholipid biosynthesis; catalyzes the reaction CDP-diaclyglycerol + L-serine = CMP + L-1-phosphatidylserine, transcriptionally repressed by myo-inositol and choline phosphatidylserine biosynthetic process CDP-diacylglycerol-serine O-phosphatidyltransferase activity mitochondrial outer membrane|integral to membrane|endoplasmic reticulum
YBL102W YBL102W SFT2 hom Verified 0.263289464570059 0.396163739683077 no 1803 0.411164869363279 1368 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Non-essential tetra-spanning membrane protein found mostly in the late Golgi, can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to mammalian syntaxin 5 Golgi to endosome transport molecular_function integral to membrane|Golgi membrane
YBR120C YBR120C CBP6 hom Verified 0.262588829738236 0.396433755294352 no 1804 0.393872838535421 1302 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex positive regulation of mitochondrial translation|mitochondrial respiratory chain complex III assembly ribosome binding mitochondrion|mitochondrial ribosome
YLR405W YLR405W DUS4 hom Verified 0.262366899717487 0.396519294623522 no 1805 0.38933527536757 1298 NA FT RNA PROCESSING|OXIDATION-REDUCTION PROCESS Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p tRNA modification tRNA dihydrouridine synthase activity cellular_component
YOR332W YOR332W VMA4 hom Verified 0.262043709604652 0.396643871921003 no 1806 0.409263200817946 1361 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Subunit E of the V1 domain of the vacuolar H+-ATPase (V-ATPase); V-ATPase is an electrogenic proton pump found throughout the endomembrane system; V1 domain has eight subunits; required for the V1 domain to assemble onto the vacuolar membrane; protein abundance increases in response to DNA replication stress vacuolar acidification proton-transporting ATPase activity, rotational mechanism vacuolar proton-transporting V-type ATPase, V1 domain|fungal-type vacuole membrane|integral to membrane
YDR169C-A_p YDR169C-A YDR169C-A hom Uncharacterized 0.261989582737961 0.396664736767968 no 1807 0.414030355285211 1359 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YER068W YER068W MOT2 hom Verified 0.261228337869243 0.396958213071553 no 1808 0.411150665197362 1354 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications deadenylation-independent decapping of nuclear-transcribed mRNA|positive regulation of transcription elongation from RNA polymerase II promoter|protein polyubiquitination|protein ubiquitination ubiquitin-protein ligase activity|sequence-specific DNA binding CCR4-NOT core complex|cytoplasm
YAR015W YAR015W ADE1 hom Verified 0.260683238897259 0.397168396343077 no 1809 0.394258688032642 1269 NA FT NUCLEOTIDE METABOLISM NUCLEUS N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase, required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine; protein abundance increases in response to DNA replication stress purine nucleotide biosynthetic process|'de novo' IMP biosynthetic process phosphoribosylaminoimidazolesuccinocarboxamide synthase activity nucleus|cytoplasm
YER068C-A_d YER068C-A YER068C-A hom Dubious 0.259803431638745 0.39750770188295 no 1810 0.399519546721162 1349 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YNL298W YNL298W CLA4 hom Verified 0.258795053071094 0.397896687481031 no 1811 0.449410630062053 1486 NA FF|FT CELL CYCLE|SIGNALING|CELL DIVISION|PROTEIN PHOSPHORYLATION NUCLEUS Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p negative regulation of gene expression|vacuole inheritance|protein phosphorylation|budding cell apical bud growth|Rho protein signal transduction|regulation of exit from mitosis|establishment of cell polarity|sterol import|response to pheromone|cytokinesis protein serine/threonine kinase activity|protein kinase activity nucleus|cellular bud|fungal-type vacuole
YOR068C YOR068C VAM10 hom Verified 0.258344547237864 0.398070504531753 no 1812 0.400605837897995 1324 NA FT MEMBRANE ORGANIZATION Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering vacuole fusion, non-autophagic molecular_function fungal-type vacuole membrane
YDR035W YDR035W ARO3 hom Verified 0.256544317027219 0.398765282520167 no 1813 0.440397895934723 1470 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS|MITOCHONDRION 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan aromatic amino acid family biosynthetic process 3-deoxy-7-phosphoheptulonate synthase activity mitochondrion|nucleus|cytoplasm
YMR178W YMR178W YMR178W hom Verified 0.256490676442709 0.398785989416664 no 1814 0.384298365580671 1272 NA FT COFACTOR METABOLISM NUCLEUS Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; YMR178W is not an essential gene; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus|cytoplasm
YGL240W YGL240W DOC1 hom Verified 0.255924759936207 0.399004467741374 no 1815 0.405384368852897 1336 NA FT CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION|PROTEOLYSIS NUCLEUS|MITOCHONDRION UBIQUITIN LIGASE COMPLEX Processivity factor required for the ubiquitination activity of the anaphase promoting complex (APC), mediates the activity of the APC by contributing to substrate recognition; involved in cyclin proteolysis; contains a conserved DOC1 homology domain activation of mitotic anaphase-promoting complex activity|chromatin assembly|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cyclin catabolic process enzyme regulator activity|mitotic anaphase-promoting complex activity mitochondrion|anaphase-promoting complex
YBR133C YBR133C HSL7 hom Verified 0.254149748374143 0.39968993556495 no 1816 0.40205796089842 1359 NA FT CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION SITE OF POLARIZED GROWTH Protein arginine N-methyltransferase; exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p; relocalizes away from bud neck upon DNA replication stress G2/M transition of mitotic cell cycle|regulation of cell cycle protein-arginine omega-N symmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity cellular bud neck
YGL259W_p YGL259W YPS5 hom Uncharacterized 0.253833991088919 0.399811906083181 no 1817 0.393283543121526 1288 NA FT PROTEOLYSIS Protein with similarity to GPI-anchored aspartic proteases such as Yap1p and Yap3p biological_process aspartic-type endopeptidase activity cellular_component
YNL228W_d YNL228W YNL228W hom Dubious 0.253661093000643 0.399878697186905 no 1818 0.414020200014342 1380 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF YNL227C/JJJ1 Unknown Unknown Unknown
YJL215C_d YJL215C YJL215C hom Dubious 0.253561535451575 0.399917157926746 no 1819 0.401307241262357 1325 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YIL131C YIL131C FKH1 hom Verified 0.253416125465417 0.399973333971479 no 1820 0.400677260062688 1337 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RNA PROCESSING|CHROMATIN ORGANIZATION|MITOCHONDRION ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Forkhead family transcription factor; has a minor role in the expression of G2/M phase genes; negatively regulates transcriptional elongation; positive role in chromatin silencing at HML and HMR; binds to the recombination enhancer near HML, and regulates donor preference during mating-type switching by positioning HML near the MAT locus through FHA-domain mediated interactions with proteins near the DSB; FKH1 has a paralog, FKH2, that arose from the whole genome duplication mRNA 3'-end processing|termination of RNA polymerase II transcription|donor selection|negative regulation of transcription involved in G1 phase of mitotic cell cycle|positive regulation of transcription involved in G2/M-phase of mitotic cell cycle|cellular response to methylmercury|positive regulation of chromatin silencing at silent mating-type cassette|negative regulation of transcription elongation from RNA polymerase II promoter|Unknown|negative regulation of transcription involved in G2/M-phase of mitotic cell cycle|chromatin remodeling RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|centromeric DNA binding nucleus
YOL087C YOL087C DUF1 hom Verified 0.253276617224968 0.400027231948489 no 1821 0.451385575228457 1479 NA Ubiquitin-binding protein of unknown function; contains one WD40 repeat in a beta-propeller fold; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; homolog of human WDR48/UAF1, which is involved in regulating the Fanconi anemia pathway; deletion mutant is sensitive to various chemicals including phenanthroline, sanguinarine, and nordihydroguaiaretic acid biological_process ubiquitin binding cytoplasm
YER093C-A YER093C-A AIM11 hom Verified 0.253120161971793 0.400087679544043 no 1822 0.401628298870392 1333 NA Protein of unknown function; null mutant is viable but shows increased loss of mitochondrial genome and synthetic interaction with prohibitin (phb1); contains an intron; YER093C-A has a paralog, YBL059W, that arose from the whole genome duplication biological_process molecular_function cellular_component
YNR049C YNR049C MSO1 hom Verified 0.253088225109231 0.400100018871417 no 1823 0.398517748554793 1311 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Probable component of the secretory vesicle docking complex; acts at a late step in secretion; shows genetic and physical interactions with Sec1p; required for prospore membrane formation during sporulation; relocalizes from bud neck to nucleus upon DNA replication stress cellular membrane fusion|ascospore-type prospore membrane assembly|vesicle docking involved in exocytosis molecular_function SNARE complex|cellular bud membrane|plasma membrane|prospore membrane|cellular bud neck|cellular bud tip
YPL103C YPL103C FMP30 hom Verified 0.252448112761807 0.400347357726899 no 1824 0.412651491376781 1345 NA FT LIPID METABOLISM MITOCHONDRION Mitochondrial inner membrane protein with a role in maintaining mitochondrial morphology and normal cardiolipin levels; proposed to be involved in N-acylethanolamine metabolism; related to mammalian N-acylPE-specific phospholipase D N-acylphosphatidylethanolamine metabolic process|N-acylethanolamine metabolic process NAPE-specific phospholipase D activity mitochondrion|integral to mitochondrial inner membrane
YPR038W_d YPR038W IRC16 hom Dubious 0.251869515485191 0.400570961609604 no 1825 0.392688997160488 1296 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene YPR037C; null mutant displays increased levels of spontaneous Rad52p foci Unknown Unknown Unknown
YML117W YML117W NAB6 hom Verified 0.250761599307279 0.400999216208915 no 1826 0.399129143011878 1298 NA Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP biological_process molecular_function cytoplasm
YPL225W YPL225W YPL225W hom Verified 0.250335277184621 0.401164038754977 no 1827 0.399828347352079 1315 NA Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress biological_process molecular_function ribosome|cytoplasm
YDL180W_p YDL180W YDL180W hom Uncharacterized 0.249465739065323 0.401500269773419 no 1828 0.410769734515568 1378 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole biological_process molecular_function integral to membrane|fungal-type vacuole
YKL150W YKL150W MCR1 hom Verified 0.249134234536353 0.401628474407662 no 1829 0.428448608748176 1417 NA FT LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS MITOCHONDRION Mitochondrial NADH-cytochrome b5 reductase, involved in ergosterol biosynthesis ergosterol biosynthetic process|cellular response to oxidative stress cytochrome-b5 reductase activity mitochondrial outer membrane|mitochondrion|integral to mitochondrial outer membrane|mitochondrial intermembrane space
YDR006C YDR006C SOK1 hom Verified 0.248376016583772 0.401921744138551 no 1830 0.390505589548126 1308 NA FT SIGNALING NUCLEUS Protein whose overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13 cAMP-mediated signaling molecular_function nucleus
YDL161W YDL161W ENT1 hom Verified 0.247839793881539 0.402129182087398 no 1831 0.390381245489787 1302 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Epsin-like protein involved in endocytosis and actin patch assembly; functionally redundant with Ent2p; binds clathrin via a clathrin-binding domain motif at C-terminus; relocalizes from bud neck to cytoplasm upon DNA replication stress actin filament organization|endocytosis|actin cortical patch assembly clathrin binding mating projection tip|actin cortical patch
YMR105C YMR105C PGM2 hom Verified 0.247403605809205 0.402297941940221 no 1832 0.397355384575662 1301 NA FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY Phosphoglucomutase; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase; protein abundance increases in response to DNA replication stress glucose 6-phosphate metabolic process|cellular calcium ion homeostasis|galactose catabolic process|cellular cation homeostasis|glucose 1-phosphate metabolic process|trehalose biosynthetic process|UDP-glucose metabolic process|glycogen biosynthetic process phosphoglucomutase activity cytoplasm
YOR183W_p YOR183W FYV12 hom Uncharacterized 0.246997978789098 0.402454894157766 no 1833 0.389523006703954 1315 NA Protein of unknown function, required for survival upon exposure to K1 killer toxin biological_process molecular_function cellular_component
YMR172C-A_d YMR172C-A YMR172C-A hom Dubious 0.246959257863826 0.402469877550046 no 1834 0.398407684758222 1339 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YKL149C YKL149C DBR1 hom Verified 0.246866772713496 0.402505666047534 no 1835 0.382540313669883 1265 NA FT RNA PROCESSING NUCLEUS RNA lariat debranching enzyme, involved in intron turnover; required for efficient Ty1 transposition snoRNA metabolic process|pseudohyphal growth|RNA catabolic process|transposition, RNA-mediated RNA lariat debranching enzyme activity nucleus
YDL203C YDL203C ACK1 hom Verified 0.246601643361777 0.402608266301283 no 1836 0.39775690596881 1306 NA FT SIGNALING|CELL WALL ORG/BIOGENESIS MITOCHONDRION Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria fungal-type cell wall organization|positive regulation of signal transduction molecular_function mitochondrion
YGR177C YGR177C ATF2 hom Verified 0.24641875098067 0.402679046248225 no 1837 0.397380232117474 1318 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Alcohol acetyltransferase, may play a role in steroid detoxification; forms volatile esters during fermentation, which is important for brewing and winemaking steroid metabolic process|response to toxin|Unknown|sterol acetylation alcohol O-acetyltransferase activity integral to endoplasmic reticulum membrane|endoplasmic reticulum|cytoplasm
YDR278C_d YDR278C YDR278C hom Dubious 0.246158931749523 0.402779602620847 no 1838 0.398557094590013 1336 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YNL032W YNL032W SIW14 hom Verified 0.246074021363737 0.402812466403559 no 1839 0.395968106790174 1300 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION Tyrosine phosphatase that plays a role in actin filament organization and endocytosis; localized to the cytoplasm actin filament organization|endocytosis|protein dephosphorylation|response to stress protein tyrosine phosphatase activity cytoplasm
YOR246C YOR246C ENV9 hom Verified 0.24589087920974 0.402883352224842 no 1840 0.406839481310177 1343 NA FF|FT OXIDATION-REDUCTION PROCESS|VACUOLAR PROTEIN PROCESSING Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts vacuole organization|vacuolar protein processing oxidoreductase activity lipid particle
YOR292C_p YOR292C YOR292C hom Uncharacterized 0.245090578024632 0.403193149065833 no 1841 0.383694476717668 1272 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YOR292C is not an essential gene biological_process molecular_function integral to membrane|fungal-type vacuole
YOR315W YOR315W SFG1 hom Verified 0.243540011641895 0.403793546569723 no 1842 0.401326237365395 1329 NA FT CELL CYCLE NUCLEUS Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate mitotic cell cycle|pseudohyphal growth molecular_function nucleus|cytoplasm
YMR042W YMR042W ARG80 hom Verified 0.243363491973631 0.403861911460009 no 1843 0.40415643107349 1349 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Transcription factor involved in regulation of arginine-responsive genes; acts with Arg81p and Arg82p Unknown|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding nucleus
YPR117W_p YPR117W YPR117W hom Uncharacterized 0.242334685570864 0.404260419694737 no 1844 0.406214111660508 1355 NA Putative protein of unknown function biological_process molecular_function cellular_component
YER007C-A YER007C-A TMA20 hom Verified 0.24114328002383 0.404722034858127 no 1845 0.391500680160391 1305 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; interacts with Tma22p; null mutant exhibits translation defects; has homology to human oncogene MCT-1; protein abundance increases in response to DNA replication stress ribosome biogenesis RNA binding ribosome|cytoplasm
YLR280C_d YLR280C YLR280C hom Dubious 0.239928126006461 0.405192988096558 no 1846 0.375742507154779 1250 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOR321W YOR321W PMT3 hom Verified 0.239190846380022 0.405478800111325 no 1847 0.394482042815806 1325 NA FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt5p, can instead interact with Pmt1p in some conditions; antifungal drug target; PMT3 has a paralog, PMT2, that arose from the whole genome duplication protein O-linked glycosylation|protein O-linked mannosylation dolichyl-phosphate-mannose-protein mannosyltransferase activity integral to membrane|dolichyl-phosphate-mannose-protein mannosyltransferase complex
YIL011W YIL011W TIR3 hom Verified 0.236777711705155 0.406414621707232 no 1848 0.377551570617327 1249 NA Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth biological_process molecular_function fungal-type cell wall
YMR275C YMR275C BUL1 hom Verified 0.235904452413616 0.406753406612096 no 1849 0.415438345871184 1400 NA FT MITOCHONDRION ORGANIZATION PLASMA MEMBRANE UBIQUITIN LIGASE COMPLEX Ubiquitin-binding component of the Rsp5p E3-ubiquitin ligase complex; disruption causes temperature-sensitive growth, overexpression causes missorting of amino acid permeases; BUL1 has a paralog, BUL2, that arose from the whole genome duplication mitochondrion inheritance|protein monoubiquitination|protein polyubiquitination ubiquitin-ubiquitin ligase activity ubiquitin ligase complex|plasma membrane
YLR329W YLR329W REC102 hom Verified 0.235173116568558 0.407037185386956 no 1850 0.418592232184462 1379 NA FT CELL CYCLE NUCLEUS|CHROMOSOME Protein involved in early stages of meiotic recombination; required for chromosome synapsis; forms a complex with Rec104p and Spo11p necessary during the initiation of recombination meiotic DNA double-strand break formation|reciprocal meiotic recombination molecular_function condensed nuclear chromosome|nucleus
YLR381W YLR381W CTF3 hom Verified 0.235015259869169 0.407098444613942 no 1851 0.383952095683916 1269 NA FT CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME KINETOCHORE Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p; may bind the kinetochore to spindle microtubules; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-I and fission yeast mis6 chromosome segregation|DNA replication initiation|establishment of mitotic sister chromatid cohesion molecular_function condensed nuclear chromosome kinetochore
YPR140W YPR140W TAZ1 hom Verified 0.23459057890537 0.407263261234918 no 1852 0.410829103595909 1345 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|LIPID METABOLISM|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; human ortholog tafazzin is implicated in Barth syndrome cardiolipin acyl-chain remodeling|mitochondrial ATP synthesis coupled electron transport|protein complex assembly|inner mitochondrial membrane organization|cardiolipin metabolic process|phospholipid biosynthetic process 1-acylglycerophosphocholine O-acyltransferase activity mitochondrial outer membrane|mitochondrion|mitochondrial inner membrane|integral to mitochondrial outer membrane
YMR278W YMR278W PGM3 hom Verified 0.234468901631413 0.407310486622052 no 1853 0.390650482779787 1299 NA FT CARBOHYDRATE METABOLISM NUCLEUS Phosphoglucomutase, catalyzes interconversion of glucose-1-phosphate and glucose-6-phospate; transcription induced in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; non-essential biological_process phosphoglucomutase activity nucleus|cytoplasm
YCR087C-A_p YCR087C-A YCR087C-A hom Uncharacterized 0.233484005291511 0.407692794151317 no 1854 0.415863712742246 1401 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YCR087C-A is not an essential gene biological_process molecular_function nucleolus
YLR368W YLR368W MDM30 hom Verified 0.233340106054737 0.407748658934345 no 1855 0.395673515535602 1310 NA FT MEMBRANE ORGANIZATION|PROTEOLYSIS|MITOCHONDRION ORGANIZATION|RNA LOCALIZATION MITOCHONDRION UBIQUITIN LIGASE COMPLEX F-box component of an SCF ubiquitin protein ligase complex; associates with and is required for Fzo1p ubiquitination and for mitochondria fusion; stimulates nuclear export of specific mRNAs; promotes ubiquitin-mediated degradation of Gal4p in some strains SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|chronological cell aging|proteolysis involved in cellular protein catabolic process|mitochondrion organization|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of mRNA export from nucleus|mitochondrial fusion ubiquitin-protein ligase activity mitochondrion|SCF ubiquitin ligase complex
YLL041C YLL041C SDH2 hom Verified 0.233258613124509 0.407780297077096 no 1856 0.3982781930648 1287 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain mitochondrial electron transport, succinate to ubiquinone|cellular respiration|tricarboxylic acid cycle succinate dehydrogenase (ubiquinone) activity mitochondrial respiratory chain complex II|mitochondrion|mitochondrial membrane
YOL062C YOL062C APM4 hom Verified 0.232932176591568 0.407907036130462 no 1857 0.401343325309611 1328 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|PLASMA MEMBRANE Mu2-like subunit of the clathrin associated protein complex (AP-2); involved in vesicle transport intracellular protein transport|vesicle-mediated transport molecular_function AP-2 adaptor complex
YML016C YML016C PPZ1 hom Verified 0.232817870386795 0.407951417817591 no 1858 0.418714492784464 1389 NA FT PROTEIN LOCALIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS NUCLEUS|PLASMA MEMBRANE Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance cellular sodium ion homeostasis|cellular protein localization|protein dephosphorylation protein serine/threonine phosphatase activity extrinsic to plasma membrane|nucleus|cytoplasm
YMR306C-A_d YMR306C-A YMR306C-A hom Dubious 0.232717239602649 0.407990490724753 no 1859 0.398781911398648 1307 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR112W_d YDR112W IRC2 hom Dubious 0.232424533555575 0.408104147789183 no 1860 0.410046609557784 1300 NA Dubious open reading frame, unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR111C; null mutant displays increased levels of spontaneous Rad52p foci Unknown Unknown Unknown
YCR037C YCR037C PHO87 hom Verified 0.230792035417753 0.408738184517238 no 1861 0.416479671423524 1378 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Low-affinity inorganic phosphate (Pi) transporter; involved in activation of PHO pathway; expression is independent of Pi concentration and Pho4p activity; contains 12 membrane-spanning segments; PHO87 has a paralog, PHO90, that arose from the whole genome duplication phosphate ion transport|transmembrane transport inorganic phosphate transmembrane transporter activity integral to membrane|membrane
YIR038C YIR038C GTT1 hom Verified 0.22868663636341 0.409556241105717 no 1862 0.401434505232983 1331 NA FT KETONE METABOLISM|AMINO ACID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p glutathione metabolic process glutathione transferase activity|glutathione peroxidase activity mitochondrial outer membrane|mitochondrion|endoplasmic reticulum|plasma membrane
YJL058C YJL058C BIT61 hom Verified 0.227680912452645 0.409947156197488 no 1863 0.401285996983804 1334 NA FT SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION PLASMA MEMBRANE Subunit of TORC2 membrane-associated complex; involved in regulation of cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; BIT61 has a paralog, BIT2, that arose from the whole genome duplication fungal-type cell wall organization|TOR signaling cascade|regulation of cell growth|establishment or maintenance of actin cytoskeleton polarity molecular_function TORC2 complex|plasma membrane|cytoplasm
YEL036C YEL036C ANP1 hom Verified 0.226109997530454 0.410557934516774 no 1864 0.438941602990218 1442 NA FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol protein N-linked glycosylation alpha-1,6-mannosyltransferase activity|mannosyltransferase activity alpha-1,6-mannosyltransferase complex|Golgi cis cisterna
YNL001W YNL001W DOM34 hom Verified 0.22526324594631 0.410887245181654 no 1865 0.42348020740222 1388 NA FT CELL CYCLE|TRANSLATION|CELL DIVISION Protein that facilitates ribosomal subunit dissociation; acts when translation is stalled, with binding partner Hbs1p; required for RNA cleavage in no-go decay, but reports conflict on endonuclease activity; Pelota ortholog; protein abundance increases in response to DNA replication stress; DOM34 has a paralog, YCL001W-B, that arose from the whole genome duplication nuclear-transcribed mRNA catabolic process, no-go decay|ribosome disassembly|nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay|nonfunctional rRNA decay ribosome binding|endoribonuclease activity cytoplasm
YKL076C_d YKL076C PSY1 hom Dubious 0.224872985367386 0.411039042818839 no 1866 0.416484649853736 1404 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C Unknown Unknown Unknown
YOR137C YOR137C SIA1 hom Verified 0.224395671467082 0.4112247192448 no 1867 0.389736208617377 1271 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Protein of unassigned function involved in activation of the Pma1p plasma membrane H+-ATPase by glucose proton transport molecular_function cellular_component
YLR352W_p YLR352W YLR352W hom Uncharacterized 0.224041770894803 0.41136240038712 no 1868 0.418337843349479 1392 NA Putative protein of unknown function with similarity to F-box proteins; interacts with Skp1p and Cdc53p; YLR352W is not an essential gene biological_process molecular_function SCF ubiquitin ligase complex
YLR034C YLR034C SMF3 hom Verified 0.223669555620073 0.411507218442601 no 1869 0.408239977956124 1352 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteins; protein abundance increases in response to DNA replication stress cellular iron ion homeostasis|iron ion transport metal ion transmembrane transporter activity fungal-type vacuole membrane|integral to membrane
YDR532C YDR532C KRE28 hom Verified 0.223026926757691 0.411757274867678 no 1870 0.427831079923243 1393 NA FT ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME|CYTOSKELETON KINETOCHORE Subunit of a kinetochore-microtubule binding complex with Spc105p that bridges centromeric heterochromatin and kinetochore MAPs and motors, and is also required for sister chromatid bi-orientation and kinetochore binding of SAC components biological_process molecular_function chromosome, centromeric region|condensed nuclear chromosome kinetochore|spindle pole body
YAL017W YAL017W PSK1 hom Verified 0.222674071236337 0.411894591435549 no 1871 0.398111247997971 1319 NA FT SIGNALING|TRANSLATION|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|GEN. OF PRECURSOR METABOLITES AND ENERGY PAS domain-containing serine/threonine protein kinase; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status; PSK1 has a paralog, PSK2, that arose from the whole genome duplication regulation of (1->6)-beta-D-glucan biosynthetic process|negative regulation of glycogen biosynthetic process|protein phosphorylation protein serine/threonine kinase activity|protein kinase activity cytoplasm
YER017C YER017C AFG3 hom Verified 0.222112129465666 0.412113297868635 no 1872 0.415340880877777 1341 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Component, with Yta12p, of the mitochondrial inner membrane m-AAA protease; mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes; involved in cytoplasmic mRNA translation and aging proteolysis|signal peptide processing|protein complex assembly|protein import into mitochondrial intermembrane space metallopeptidase activity|protein binding|ATPase activity mitochondrion|mitochondrial inner boundary membrane|mitochondrial inner membrane|m-AAA complex
YOR363C YOR363C PIP2 hom Verified 0.222036915026496 0.412142573226762 no 1873 0.398299339333368 1297 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS NUCLEUS Autoregulatory oleate-specific transcriptional activator of peroxisome proliferation, contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes; PIP2 has a paralog, OAF1, that arose from the whole genome duplication cellular response to oleic acid|positive regulation of fatty acid beta-oxidation|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription integral to membrane|nucleus
YOR197W YOR197W MCA1 hom Verified 0.220720962763924 0.41265485402946 no 1874 0.407127858865529 1326 NA FT PROTEOLYSIS NUCLEUS Ca2+-dependent cysteine protease; may cleave specific substrates during the stress response; regulates apoptosis upon H2O2 treatment; required for clearance of insoluble protein aggregates during normal growth; implicated in cell cycle dynamics; undergoes autocatalytic processing; similar to mammalian metacaspases, but exists as a monomer due to an extra pair of anti-parallel beta-strands that form a continuous beta-sheet, blocking potential dimerization misfolded or incompletely synthesized protein catabolic process|apoptotic process cysteine-type peptidase activity nucleus
YLR003C YLR003C CMS1 hom Verified 0.220598390256772 0.412702577287537 no 1875 0.395418275761296 1324 NA FT NUCLEUS Putative subunit of the 90S preribosome processome complex; overexpression rescues supressor mutant of mcm10; null mutant is viable; relocalizes from nucleus to cytoplasm upon DNA replication stress biological_process molecular_function nucleus|90S preribosome
YDL044C YDL044C MTF2 hom Verified 0.219968216624924 0.412947953960777 no 1876 0.424465294162282 1382 NA FT RNA PROCESSING|TRANSLATION MITOCHONDRION Mitochondrial matrix protein that interacts with an N-terminal region of mitochondrial RNA polymerase (Rpo41p) and couples RNA processing and translation to transcription cytoplasmic translation|mRNA processing RNA binding mitochondrion
YPL147W YPL147W PXA1 hom Verified 0.219700931119657 0.413052039727493 no 1877 0.409728156298402 1337 NA FT NUCLEOTIDE METABOLISM Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter ABCD1 and ABCD2 and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder fatty acid transport ATPase activity, coupled to transmembrane movement of substances integral to membrane|integral to peroxisomal membrane
YLR218C YLR218C COA4 hom Verified 0.219545864354976 0.413112428307328 no 1878 0.391858593279409 1277 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION NUCLEUS|MITOCHONDRION Twin Cx(9)C protein involved in cytochrome c oxidase assembly or stability; localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; interacts genetically with CYC1 and with cytochrome c oxidase assembly factors mitochondrial respiratory chain complex IV assembly|mitochondrial respiratory chain complex assembly molecular_function nucleus|mitochondrial intermembrane space|cytoplasm
YBL031W YBL031W SHE1 hom Verified 0.218720576235537 0.413433859762166 no 1879 0.428055289304086 1408 NA FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON Mitotic spindle protein; interacts with components of the Dam1 (DASH) complex, its effector Sli15p, and microtubule-associated protein Bim1p; also localizes to nuclear microtubules and to the bud neck in a ring-shaped structure; inhibits dynein function mitotic spindle elongation molecular_function microtubule cytoskeleton|nuclear microtubule|cellular bud neck|astral microtubule|spindle
YOL141W YOL141W PPM2 hom Verified 0.218662738274461 0.413456388545981 no 1880 0.384101228488884 1271 NA FT RNA PROCESSING MITOCHONDRION AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p tRNA methylation|wybutosine biosynthetic process tRNA methyltransferase activity mitochondrion|cytoplasm
YJL052W YJL052W TDH1 hom Verified 0.218429827467896 0.413547113804412 no 1881 0.416828118770459 1372 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress gluconeogenesis|glycolysis glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity mitochondrion|fungal-type cell wall|lipid particle|plasma membrane|cytoplasm
YBL082C YBL082C ALG3 hom Verified 0.2183835151379 0.413565154299568 no 1882 0.407110228867676 1335 NA FT LIPID METABOLISM|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins oligosaccharide-lipid intermediate biosynthetic process|protein glycosylation alpha-1,3-mannosyltransferase activity integral to membrane|endoplasmic reticulum
YDR346C YDR346C SVF1 hom Verified 0.218183564846138 0.413643044987559 no 1883 0.431927931979999 1428 NA FT RESPONSE TO OXIDATIVE STRESS NUCLEUS Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis; mutant has increased aneuploidy tolerance cellular response to oxidative stress molecular_function nucleus|cytoplasm
YBR145W YBR145W ADH5 hom Verified 0.217584188180143 0.413876552671889 no 1884 0.414457404145125 1360 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM NUCLEUS Alcohol dehydrogenase isoenzyme V; involved in ethanol production; ADH5 has a paralog, ADH1, that arose from the whole genome duplication NADH oxidation|ethanol biosynthetic process involved in glucose fermentation to ethanol|amino acid catabolic process to alcohol via Ehrlich pathway alcohol dehydrogenase (NAD) activity nucleus|cytoplasm
YGL109W_d YGL109W YGL109W hom Dubious 0.21718196996963 0.414033267615992 no 1885 0.403301744275222 1333 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized gene YGL108C Unknown Unknown Unknown
YBR073W YBR073W RDH54 hom Verified 0.217070534359432 0.41407668832523 no 1886 0.447687162357354 1482 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS DNA-dependent ATPase; stimulates strand exchange by modifying the topology of double-stranded DNA; involved in recombinational repair of DNA double-strand breaks during mitosis and meiosis; proposed to be involved in crossover interference; interacts with Dmc1p; stimulates Dmc1p and Rad51p DNA geometric change|heteroduplex formation|meiotic sister chromatid segregation|reciprocal meiotic recombination|double-strand break repair via break-induced replication DNA-dependent ATPase activity|DNA translocase activity nucleus
YER096W YER096W SHC1 hom Verified 0.216145500101132 0.414437166959876 no 1887 0.422727891665687 1379 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM Sporulation-specific activator of Chs3p (chitin synthase III); required for the synthesis of the chitosan layer of ascospores; transcriptionally induced at alkaline pH; SHC1 has a paralog, SKT5, that arose from the whole genome duplication ascospore formation|chitin biosynthetic process enzyme activator activity prospore membrane
YJR079W_p YJR079W YJR079W hom Uncharacterized 0.215873646033645 0.414543120087253 no 1888 0.43238695226498 1423 NA Putative protein of unknown function; mutation results in impaired mitochondrial respiration biological_process molecular_function cellular_component
YKR055W YKR055W RHO4 hom Verified 0.215463940246349 0.414702811655457 no 1889 0.410272609038402 1387 NA FT SIGNALING|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely to be involved in the establishment of cell polarity positive regulation of formin-nucleated actin cable assembly|maintenance of cell polarity|regulation of formin-nucleated actin cable assembly GTPase activity incipient cellular bud site|plasma membrane|cellular bud neck
YHR030C YHR030C SLT2 hom Verified 0.215170243731809 0.414817294812147 no 1890 0.450358125171373 1498 NA FF|FT PROTEIN LOCALIZATION|RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|CELL DIVISION|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION NUCLEUS|SITE OF POLARIZED GROWTH Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, progression through the cell cycle, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to the phagophore assembly site (PAS); regulated by the PKC1-mediated signaling pathway protein phosphorylation|endoplasmic reticulum unfolded protein response|signal transduction|UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response|fungal-type cell wall organization|peroxisome degradation|regulation of transcription factor import into nucleus|barrier septum assembly|response to acid|regulation of cell size MAP kinase activity|protein serine/threonine kinase activity|protein kinase activity nucleus|cytoplasm|cellular bud tip
YIL125W YIL125W KGD1 hom Verified 0.214880542837309 0.414930227560704 no 1891 0.427371711542794 1431 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA tricarboxylic acid cycle|2-oxoglutarate metabolic process oxoglutarate dehydrogenase (succinyl-transferring) activity mitochondrial nucleoid|mitochondrion|mitochondrial matrix|mitochondrial oxoglutarate dehydrogenase complex
YJL056C YJL056C ZAP1 hom Verified 0.214639447245533 0.415024218091217 no 1892 0.499260404185738 1672 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS NUCLEUS Zinc-regulated transcription factor; binds to zinc-responsive promoters to induce transcription of certain genes in presence of zinc, represses other genes in low zinc; regulates its own transcription; contains seven zinc-finger domains regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation|positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding RNA polymerase II transcription factor activity|RNA polymerase II regulatory region sequence-specific DNA binding|zinc ion binding nucleus
YHR060W YHR060W VMA22 hom Verified 0.214256443243969 0.415173541269285 no 1893 0.425572244129777 1395 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Peripheral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER) vacuolar proton-transporting V-type ATPase complex assembly|vacuolar acidification unfolded protein binding extrinsic to endoplasmic reticulum membrane
YDR538W YDR538W PAD1 hom Verified 0.214201586774833 0.415194929366307 no 1894 0.405177250069554 1334 NA FT KETONE METABOLISM MITOCHONDRION Phenylacrylic acid decarboxylase, confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives; also has mRNA binding activity; homolog of E. coli UbiX cinnamic acid catabolic process|aromatic compound catabolic process mRNA binding|carboxy-lyase activity mitochondrion
YDR426C_d YDR426C YDR426C hom Dubious 0.214122990571681 0.415225573833057 no 1895 0.405340821277459 1340 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SNX41 Unknown Unknown Unknown
YOR349W YOR349W CIN1 hom Verified 0.213472213308087 0.415479330088313 no 1896 0.419906187077087 1378 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl protein folding|tubulin complex assembly|tubulin complex biogenesis beta-tubulin binding cellular_component
YOL047C_p YOL047C YOL047C hom Uncharacterized 0.212376785475824 0.415906547599827 no 1897 0.415381205980969 1356 NA Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern biological_process molecular_function integral to membrane|cytoplasm
YNL204C YNL204C SPS18 hom Verified 0.212151546681305 0.41599440320136 no 1898 0.426143007306152 1409 NA FT SIGNALING|NUCLEOTIDE METABOLISM Protein of unknown function, contains a putative zinc-binding domain; expressed during sporulation sporulation resulting in formation of a cellular spore molecular_function cellular_component
YDR074W YDR074W TPS2 hom Verified 0.209878696238816 0.416881174927904 no 1899 0.49120113930552 1734 NA FT CARBOHYDRATE METABOLISM MITOCHONDRION Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex; involved in synthesis of the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; protein abundance increases in response to DNA replication stress trehalose biosynthetic process|response to stress trehalose-phosphatase activity mitochondrion|alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
YER140W YER140W EMP65 hom Verified 0.209650074889545 0.416970396964345 no 1900 0.413563956334315 1369 NA FT MITOCHONDRION ER membrane protein of unknown function; forms an ER-membrane associated protein complex with Slp1p; identified along with SLP1 in a screen for mutants defective in the unfolded protein response (UPR); proposed to function in the folding of integral membrane proteins; interacts genetically with MPS1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies protein folding in endoplasmic reticulum molecular_function mitochondrion|integral to membrane
YCR007C_p YCR007C YCR007C hom Uncharacterized 0.20954029837848 0.417013239994571 no 1901 0.422221596956389 1399 NA Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene biological_process molecular_function cellular_component
YDR271C_d YDR271C YDR271C hom Dubious 0.209056520725774 0.417202058063136 no 1902 0.427937936236697 1418 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W Unknown Unknown Unknown
YDR250C_d YDR250C YDR250C hom Dubious 0.209035143853186 0.417210401881961 no 1903 0.417966767279803 1391 NA Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data Unknown Unknown Unknown
YFL016C YFL016C MDJ1 hom Verified 0.208638297191608 0.41736530579918 no 1904 0.47873020707437 1602 NA FT PROTEOLYSIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones protein refolding|response to heat|misfolded or incompletely synthesized protein catabolic process|mitochondrial genome maintenance|'de novo' protein folding unfolded protein binding|ATPase activator activity extrinsic to mitochondrial inner membrane|mitochondrion|mitochondrial matrix
YMR135W-A_d YMR135W-A YMR135W-A hom Dubious 0.208093369521524 0.417578032099653 no 1905 0.39371036887237 1287 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YBR290W YBR290W BSD2 hom Verified 0.20750818233425 0.417806501582286 no 1906 0.427573027785301 1428 NA FT PROTEIN LOCALIZATION|ION HOMEOSTASIS|PROTEOLYSIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT ENDOPLASMIC RETICULUM Heavy metal ion homeostasis protein, facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded, controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification metal ion transport|ubiquitin-dependent protein catabolic process|protein targeting to vacuole protein binding fungal-type vacuole membrane|integral to membrane|endoplasmic reticulum
YJR011C_p YJR011C YJR011C hom Uncharacterized 0.207045512217752 0.417987157446956 no 1907 0.415010198361788 1354 NA Putative protein of unknown function; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS biological_process molecular_function cellular_component
YIL017C YIL017C VID28 hom Verified 0.206570552433209 0.418172629982183 no 1908 0.406309313835021 1356 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS NUCLEUS GID Complex subunit, serves as adaptor for regulatory subunit Vid24p; protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); localized to the nucleus and the cytoplasm negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|vacuolar protein catabolic process|ascospore formation|positive regulation of transcription from RNA polymerase II promoter molecular_function nucleus|GID complex|cytoplasm
YCR020W-B YCR020W-B HTL1 hom Verified 0.205202157681913 0.418707091864853 no 1909 0.430481355983302 1428 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS RSC COMPLEX Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance regulation of cell cycle|nucleosome disassembly|response to DNA damage stimulus|chromatin remodeling|transcription elongation from RNA polymerase II promoter chromatin binding RSC complex
YPL256C YPL256C CLN2 hom Verified 0.204989623631467 0.418790116013724 no 1910 0.411424745731808 1348 NA FT CELL CYCLE|SIGNALING|CELL DIVISION|PROTEIN PHOSPHORYLATION NUCLEUS G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p) regulation of cyclin-dependent protein kinase activity|re-entry into mitotic cell cycle after pheromone arrest cyclin-dependent protein kinase regulator activity cyclin-dependent protein kinase holoenzyme complex|nucleus|cytoplasm
YPL058C YPL058C PDR12 hom Verified 0.204753245217261 0.418882458956283 no 1911 0.420286111150584 1361 NA FT KETONE METABOLISM|NUCLEOTIDE METABOLISM PLASMA MEMBRANE Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity propionate metabolic process|transport|organic acid transport xenobiotic-transporting ATPase activity|organic acid transmembrane transporter activity integral to membrane|plasma membrane
YHL017W_p YHL017W YHL017W hom Uncharacterized 0.204320588904579 0.419051490857513 no 1912 0.411652406029992 1342 NA FT GOLGI APPARATUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein co-localizes with clathrin-coated vesicles; YHL017W has a paralog, PTM1, that arose from the whole genome duplication biological_process molecular_function integral to membrane|clathrin-coated vesicle
YDR198C YDR198C RKM2 hom Verified 0.204263938092157 0.419073624530879 no 1913 0.435908286249699 1457 NA Ribosomal protein lysine methyltransferase, responsible for trimethylation of the lysine residue at position 3 of Rpl12Ap and Rpl12Bp peptidyl-lysine trimethylation|peptidyl-lysine monomethylation protein-lysine N-methyltransferase activity cellular_component
YJL020C YJL020C BBC1 hom Verified 0.203890557743514 0.419219511961508 no 1914 0.401957937886931 1320 NA FT CYTOSKELETON ORGANIZATION CYTOSKELETON Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches actin cytoskeleton organization myosin I binding actin cortical patch
YKL162C-A_d YKL162C-A YKL162C-A hom Dubious 0.203855306992382 0.419233285733704 no 1915 0.416763925646831 1371 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGR071C YGR071C ENV11 hom Verified 0.20338659840512 0.419416436914808 no 1916 0.418347786902676 1397 NA FT VACUOLAR PROTEIN PROCESSING NUCLEUS Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and fragmented vacuoles; deletion mutant has increased glycogen accumulation and displays elongated buds; green fluorescent protein (GFP)-fusion protein localizes to the nucleus vacuole organization|vacuolar protein processing molecular_function nucleus
YBR032W_d YBR032W YBR032W hom Dubious 0.202919756140465 0.419598876173572 no 1917 0.391880873496285 1321 NA Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data Unknown Unknown Unknown
YPL113C_p YPL113C YPL113C hom Uncharacterized 0.20219423117311 0.419882441425907 no 1918 0.393788945316576 1315 NA FT OXIDATION-REDUCTION PROCESS Glyoxylate reductase; acts on glyoxylate and hydroxypyruvate substrates; YPL113C is not an essential gene metabolic process oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor cellular_component
YOR200W_d YOR200W YOR200W hom Dubious 0.202130149334962 0.41990748926797 no 1919 0.441084038521495 1467 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRM1/YOR201c Unknown Unknown Unknown
YER174C YER174C GRX4 hom Verified 0.20107678076634 0.420319268727019 no 1920 0.420807942558742 1372 NA FT ION HOMEOSTASIS|CYTOSKELETON ORGANIZATION|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS NUCLEUS Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx3p and Grx5p; protects cells from oxidative damage; mutant has increased aneuploidy tolerance; transcription is regulated by Yap5 cellular iron ion homeostasis|cellular response to oxidative stress|actin cytoskeleton organization disulfide oxidoreductase activity nucleus
YAL044W-A_p YAL044W-A YAL044W-A hom Uncharacterized 0.201024167274181 0.420339838515318 no 1921 0.39244392237948 1281 NA Putative protein of unknown function; similar to S. pombe uvi31 which is a putative DNA repair protein biological_process molecular_function cellular_component
YDR263C YDR263C DIN7 hom Verified 0.200354475483967 0.420601680429048 no 1922 0.429327533639182 1414 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination DNA repair nuclease activity mitochondrion
YBR272C YBR272C HSM3 hom Verified 0.200312433321805 0.420618119612105 no 1923 0.416881063194616 1395 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE NUCLEUS Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); involved in DNA mismatch repair during slow growth; weak similarity to Msh1p; related to human 19S subunit S5b; structural study suggests Hsm3p is a scaffold protein for Rpt1p-Rpt2p complex formation mismatch repair|proteasome regulatory particle assembly molecular_function cytosol|proteasome regulatory particle, base subcomplex|nucleus|cytoplasm
YDR316W YDR316W OMS1 hom Verified 0.199904557758089 0.420777612908448 no 1924 0.433325896300053 1421 NA FT MITOCHONDRION Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif; multicopy suppressor of respiratory defects caused by OXA1 mutations biological_process S-adenosylmethionine-dependent methyltransferase activity mitochondrial envelope|mitochondrion
YGL043W YGL043W DST1 hom Verified 0.199820528595248 0.420810472801689 no 1925 0.423704185437017 1380 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION NUCLEUS General transcription elongation factor TFIIS, enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites; maintains RNAPII elongation activity on ribosomal protein genes during conditions of transcriptional stress transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|mRNA cleavage|maintenance of transcriptional fidelity during DNA-dependent transcription elongation from RNA polymerase II promoter|tRNA transcription from RNA polymerase III promoter|regulation of mRNA 3'-end processing|positive regulation of transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|transcription antitermination|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter RNA polymerase II regulatory region DNA binding|RNA polymerase II core binding|core RNA polymerase II recruiting transcription factor activity nucleus
YBR213W YBR213W MET8 hom Verified 0.198939364873431 0.421155088093677 no 1926 0.444234967184761 1469 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM Bifunctional dehydrogenase and ferrochelatase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis siroheme biosynthetic process|sulfate assimilation precorrin-2 dehydrogenase activity|ferrochelatase activity cellular_component
YGR164W_d YGR164W YGR164W hom Dubious 0.198200416620392 0.421444130768145 no 1927 0.421002658131775 1425 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR393W YLR393W ATP10 hom Verified 0.198173617517642 0.421454614144805 no 1928 0.411331658285197 1352 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, interacts genetically with ATP6 mitochondrial proton-transporting ATP synthase complex assembly unfolded protein binding integral to mitochondrial membrane|mitochondrion|mitochondrial inner membrane
YGR111W_p YGR111W YGR111W hom Uncharacterized 0.197821700501983 0.421592283567296 no 1929 0.44458750385333 1461 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus regulation of cell size molecular_function nucleus|cytoplasm
YCL035C YCL035C GRX1 hom Verified 0.197776784822927 0.421609855205381 no 1930 0.415194385040382 1370 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS NUCLEUS Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress protein glutathionylation|cellular response to oxidative stress disulfide oxidoreductase activity|glutathione transferase activity|glutathione peroxidase activity nucleus|cytoplasm
YHR048W_p YHR048W YHK8 hom Uncharacterized 0.19737567731259 0.421766780956984 no 1931 0.451220928160941 1506 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Presumed antiporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles drug transport molecular_function integral to membrane
YIL066C YIL066C RNR3 hom Verified 0.197173253673979 0.421845980108053 no 1932 0.426410080774813 1401 NA FT OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM MITOCHONDRION Minor isoform of the large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits deoxyribonucleotide biosynthetic process ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor mitochondrion|ribonucleoside-diphosphate reductase complex|cytoplasm
YIL135C YIL135C VHS2 hom Verified 0.196482854794127 0.422116125505615 no 1933 0.395773623833546 1290 NA FT CELL CYCLE Cytoplasmic protein of unknown function; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; similar to Mlf3p G1/S transition of mitotic cell cycle molecular_function cytoplasm
YGL054C YGL054C ERV14 hom Verified 0.196234620877477 0.422213265638149 no 1934 0.497651497187813 1663 NA FF|FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|SIGNALING|CELL DIVISION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS COPII-coated vesicle protein; involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon; ERV14 has a paralog, ERV15, that arose from the whole genome duplication ascospore formation|ER to Golgi vesicle-mediated transport|axial cellular bud site selection molecular_function integral to membrane|ER to Golgi transport vesicle|endoplasmic reticulum membrane
YFR030W YFR030W MET10 hom Verified 0.195829420809639 0.422371840710442 no 1935 0.419841698314477 1414 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY Subunit alpha of assimilatory sulfite reductase, which converts sulfite into sulfide sulfate assimilation sulfite reductase (NADPH) activity sulfite reductase complex (NADPH)
YIR002C YIR002C MPH1 hom Verified 0.195673405413305 0.42243290070235 no 1936 0.411610870096846 1363 NA FT RESPONSE TO DNA DAMAGE NUCLEUS 3'-5' DNA helicase involved in error-free bypass of DNA lesions; binds to flap DNA in an error-free bypass pathway and stimulates the activity of Rad27p and Dna2p; also involved in interstrand cross-link repair mutations confer a mutator phenotype; similarity to FANCM, a human Fanconi anemia complementation group protein that along with the MHF complex is involved in stabilizing and remodeling blocked replication forks; member of the SF2 DExD/H superfamily of helicases negative regulation of strand invasion|recombinational repair|DNA replication, Okazaki fragment processing flap-structured DNA binding|3'-5' DNA helicase activity nucleus
YOL064C YOL064C MET22 hom Verified 0.19552367488385 0.422491502728953 no 1937 0.420596937595483 1379 NA FT KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM NUCLEUS Bisphosphate-3'-nucleotidase, involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway methionine biosynthetic process|hyperosmotic salinity response|sulfate assimilation 3'(2'),5'-bisphosphate nucleotidase activity cellular_component
YPL071C_p YPL071C YPL071C hom Uncharacterized 0.194363140269716 0.42294577466596 no 1938 0.406559050804061 1324 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus biological_process molecular_function nucleus|cytoplasm
YBR263W YBR263W SHM1 hom Verified 0.194208443030811 0.423006336075913 no 1939 0.388017790124075 1270 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Mitochondrial serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine serine family amino acid biosynthetic process|one-carbon metabolic process glycine hydroxymethyltransferase activity mitochondrion
YIL035C YIL035C CKA1 hom Verified 0.193438872137815 0.423307637362308 no 1940 0.408768916149426 1361 NA FT RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION NUCLEUS Alpha catalytic subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; regulates Fkh1p-mediated donor preference during mating-type switching regulation of transcription from RNA polymerase I promoter|protein phosphorylation|regulation of transcription from RNA polymerase III promoter|response to DNA damage stimulus protein serine/threonine kinase activity|protein kinase activity protein kinase CK2 complex|UTP-C complex
YDR220C_d YDR220C YDR220C hom Dubious 0.193310468791019 0.423357914026699 no 1941 0.415984035488633 1386 NA Dubious open reading frame, null mutant exhibits synthetic phenotype with alpha-synuclein Unknown Unknown Unknown
YPL140C YPL140C MKK2 hom Verified 0.193251246091734 0.423381103249215 no 1942 0.423874733682213 1394 NA FT SIGNALING|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1p; MKK2 has a paralog, MKK1, that arose from the whole genome duplication signal transduction|peroxisome degradation|protein phosphorylation MAP kinase kinase activity intracellular
YDR535C_d YDR535C YDR535C hom Dubious 0.192728848572466 0.423585664553271 no 1943 0.456522824222195 1511 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YDR535C is not an essential gene. Unknown Unknown Unknown
YBR264C YBR264C YPT10 hom Verified 0.192584150088745 0.423642329475142 no 1944 0.425428700306627 1411 NA FT PROTEIN LOCALIZATION|SIGNALING PLASMA MEMBRANE Rab family GTP-binding protein that contains the PEST signal sequence specific for proteolytic enzymes; may be involved in vesicular transport; overexpression leads to accumulation of Golgi-like cisternae with budding vesicles Golgi organization GTPase activity|guanyl nucleotide binding cytoplasm
YGR130C YGR130C YGR130C hom Verified 0.192255377287028 0.4237710850347 no 1945 0.434788898653435 1449 NA Component of the eisosome with unknown function; GFP-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7) biological_process molecular_function eisosome|membrane raft|cytoplasm
YGL119W YGL119W COQ8 hom Verified 0.191548387831114 0.424047987139768 no 1946 0.413338007323107 1363 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication ubiquinone biosynthetic process|aerobic respiration molecular_function mitochondrion|extrinsic to mitochondrial inner membrane|mitochondrial matrix
YLR283W_p YLR283W YLR283W hom Uncharacterized 0.1914026369418 0.42410507713902 no 1947 0.412252376529404 1357 NA FT MITOCHONDRION Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR283W is not an essential gene biological_process molecular_function mitochondrion
YDL229W YDL229W SSB1 hom Verified 0.191104216023644 0.424221972302394 no 1948 0.413402226798453 1359 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RESPONSE TO NUTRIENT LEVELS Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in folding of newly-made polypeptide chains; member of the HSP70 family; interacts with phosphatase subunit Reg1p; SSB1 has a paralog, SSB2, that arose from the whole genome duplication cytoplasmic translation|cellular response to glucose starvation|translational termination|ribosomal subunit export from nucleus|regulation of translational fidelity|rRNA processing|'de novo' cotranslational protein folding unfolded protein binding|ATPase activity|calmodulin binding plasma membrane|polysome|cytoplasm
YMR303C YMR303C ADH2 hom Verified 0.19088326689869 0.424308525102312 no 1949 0.4174264302027 1372 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1 ethanol metabolic process|NADH oxidation|fermentation|amino acid catabolic process to alcohol via Ehrlich pathway alcohol dehydrogenase (NAD) activity cytoplasm
YDR441C YDR441C APT2 hom Verified 0.190651104455967 0.424399474448466 no 1950 0.424401993934874 1402 NA Potential adenine phosphoribosyltransferase; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity; APT2 has a paralog, APT1, that arose from the whole genome duplication biological_process adenine phosphoribosyltransferase activity|molecular_function cytoplasm
YIL102C_p YIL102C YIL102C hom Uncharacterized 0.190230987316228 0.424564065042177 no 1951 0.414261369879745 1356 NA Putative protein of unknown function biological_process molecular_function cellular_component
YMR283C YMR283C RIT1 hom Verified 0.189922205015136 0.42468504603004 no 1952 0.387751784750738 1296 NA FT RNA PROCESSING 2'-O-ribosyl phosphate transferase, modifies the initiator methionine tRNA at position 64 to distinguish it from elongator methionine tRNA charged-tRNA amino acid modification transferase activity, transferring pentosyl groups cytoplasm
YNL097C YNL097C PHO23 hom Verified 0.188452228435854 0.425261080340493 no 1953 0.405745994117152 1341 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5; affects termination of snoRNAs and cryptic unstable transcripts (CUTs); C-terminus has similarity to human candidate tumor suppressor p33(ING1) and its isoform ING3 positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of transcription from RNA polymerase I promoter|negative regulation of chromatin silencing at telomere|negative regulation of chromatin silencing at rDNA|chromatin modification|positive regulation of transcription from RNA polymerase II promoter methylated histone residue binding histone deacetylase complex|Rpd3L-Expanded complex|nucleus|Rpd3L complex
YAL005C YAL005C SSA1 hom Verified 0.187946375693046 0.425459343963147 no 1954 0.398682522962119 1322 NA FT PROTEIN LOCALIZATION|TRANSLATION|MITOCHONDRION ORGANIZATION NUCLEUS ATPase involved in protein folding and NLS-directed nuclear transport; member of HSP70 family; forms chaperone complex with Ydj1p; localized to nucleus, cytoplasm, and cell wall; 98% identical with paralog Ssa2p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes; general targeting factor of Hsp104p to prion fibrils cytoplasmic translation|protein folding|protein refolding|protein targeting to mitochondrion|SRP-dependent cotranslational protein targeting to membrane, translocation|protein import into nucleus, translocation|response to stress unfolded protein binding|ATPase activity fungal-type vacuole membrane|fungal-type cell wall|plasma membrane|nucleus|polysome|chaperonin-containing T-complex|cytoplasm
YMR027W_p YMR027W YMR027W hom Uncharacterized 0.187750865241728 0.4255359772664 no 1955 0.419382903066704 1404 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR027W is not an essential gene biological_process molecular_function nucleus|cytoplasm
YOR020W-A_p YOR020W-A YOR020W-A hom Uncharacterized 0.186586694979736 0.425992349704769 no 1956 0.432372841487077 1412 NA FT MITOCHONDRION Putative protein of unknown function, conserved in A. gossypii; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YKL064W YKL064W MNR2 hom Verified 0.18617598127549 0.426153379409087 no 1957 0.427240283628093 1405 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Vacuolar membrane protein required for magnesium homeostasis; putative magnesium transporter; has similarity to Alr1p and Alr2p, which mediate influx of Mg2+ and other divalent cations cellular magnesium ion homeostasis magnesium ion transmembrane transporter activity fungal-type vacuole membrane|integral to membrane
YNR062C_p YNR062C YNR062C hom Uncharacterized 0.186161480077509 0.426159065160732 no 1958 0.395608144640779 1303 NA Putative membrane protein of unknown function biological_process molecular_function integral to membrane
YPR164W YPR164W MMS1 hom Verified 0.185315021608531 0.426490978273914 no 1959 0.43090712661744 1425 NA FT RESPONSE TO DNA DAMAGE NUCLEUS UBIQUITIN LIGASE COMPLEX Subunit of an E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of the replication fork such as the fork-pausing complex and leading strand polymerase, preventing fork collapse and promoting efficient recovery during replication stress; regulates Ty1 transposition; involved with Rtt101p in nonfunctional rRNA decay replication fork processing|negative regulation of transposition, RNA-mediated|recombinational repair|nonfunctional rRNA decay molecular_function Cul8-RING ubiquitin ligase complex
YJR133W YJR133W XPT1 hom Verified 0.184524900493659 0.426800847386034 no 1960 0.438482629593769 1428 NA FT NUCLEOTIDE METABOLISM Xanthine-guanine phosphoribosyl transferase, required for xanthine utilization and for optimal utilization of guanine XMP salvage|hypoxanthine metabolic process xanthine phosphoribosyltransferase activity|hypoxanthine phosphoribosyltransferase activity cytoplasm
YGR290W_d YGR290W YGR290W hom Dubious 0.183497529030405 0.427203828703683 no 1961 0.440487394956249 1445 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; putative HLH protein; partially overlaps the verified ORF MAL11/YGR289C (a high-affinity maltose transporter) Unknown Unknown Unknown
YHR192W YHR192W LNP1 hom Verified 0.182292082252709 0.427676756014795 no 1962 0.466698000139929 1554 NA Lunapark family member involved in ER network formation; localizes to ER junctions and this localization is regulated by the yeast atlastin ortholog Sey1p; interacts with the reticulon protein Rtn1p; induced in response to the DNA-damaging agent MMS endoplasmic reticulum tubular network organization molecular_function endoplasmic reticulum tubular network|cytoplasm
YER019W YER019W ISC1 hom Verified 0.181542943287619 0.427970714618569 no 1963 0.434985266845615 1420 NA FT LIPID METABOLISM ENDOPLASMIC RETICULUM|MITOCHONDRION Mitochondrial membrane localized inositol phosphosphingolipid phospholipase C, hydrolyzes complex sphingolipids to produce ceramide; activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol; mediates Na+ and Li+ halotolerance response to salt stress|ceramide biosynthetic process|sphingolipid catabolic process inositol phosphosphingolipid phospholipase activity mitochondrion|endoplasmic reticulum|integral to mitochondrial outer membrane
YDR076W YDR076W RAD55 hom Verified 0.181526423532809 0.427977197343734 no 1964 0.454285469897833 1504 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p DNA recombinase assembly|heteroduplex formation|meiotic DNA recombinase assembly|double-strand break repair via single-strand annealing DNA-dependent ATPase activity|protein heterodimerization activity nucleus|Rhp55-Rhp57 complex
YER123W YER123W YCK3 hom Verified 0.181473655654105 0.427997904782206 no 1965 0.455782516126509 1523 NA FT VESICLE-MEDIATED TRANSPORT|PROTEIN PHOSPHORYLATION ENDOMEMBRANE SYSTEM|NUCLEUS|PLASMA MEMBRANE Palmitoylated, vacuolar membrane-localized casein kinase I isoform; negatively regulates vacuole fusion during hypertonic stress via phosphorylation of Vps41p; shares essential functions with Hrr25p; regulates vesicle fusion in AP-3 pathway vesicle-mediated transport|protein phosphorylation protein serine/threonine kinase activity|protein kinase activity fungal-type vacuole membrane|plasma membrane|nucleus|fungal-type vacuole
YNL154C YNL154C YCK2 hom Verified 0.180848844517972 0.428243111395246 no 1966 0.433542662718496 1453 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL DIVISION|PROTEIN PHOSPHORYLATION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; YCK2 has a paralog, YCK1, that arose from the whole genome duplication endocytosis|cell morphogenesis|protein phosphorylation|cytokinesis|response to glucose stimulus protein serine/threonine kinase activity|protein kinase activity plasma membrane|cellular bud neck|mating projection
YHR209W YHR209W CRG1 hom Verified 0.179856126463092 0.428632759723007 no 1967 0.429510509129721 1414 NA S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin lipid homeostasis mRNA binding|S-adenosylmethionine-dependent methyltransferase activity|methyltransferase activity cellular_component
YLR432W YLR432W IMD3 hom Verified 0.179434111151969 0.428798424589465 no 1968 0.45390332222822 1499 NA FT OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed GTP biosynthetic process IMP dehydrogenase activity plasma membrane|cytoplasm
YKR095W YKR095W MLP1 hom Verified 0.179108324609415 0.428926322806374 no 1969 0.433621417079654 1398 NA FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs protein localization to nuclear pore|poly(A)+ mRNA export from nucleus|protein import into nucleus|transcriptional activation by promoter-terminator looping|nuclear retention of unspliced pre-mRNA at the site of transcription|telomere tethering at nuclear periphery ribonucleoprotein complex binding nucleoplasm|nuclear envelope|integral to membrane|ribonucleoprotein complex|spindle pole body
YJR005C-A_p YJR005C-A YJR005C-A hom Uncharacterized 0.178548504500172 0.429146116016832 no 1970 0.42431046637654 1390 NA Putative protein of unknown function; originally identified as a syntenic homolog of an Ashbya gossypii gene; YJR005C-A has a paralog, YGR169C-A, that arose from the whole genome duplication biological_process molecular_function cellular_component
YHR176W YHR176W FMO1 hom Verified 0.17805098012446 0.42934146949176 no 1971 0.432978484538991 1424 NA FT OXIDATION-REDUCTION PROCESS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins protein folding N,N-dimethylaniline monooxygenase activity endoplasmic reticulum membrane
YDR319C_p YDR319C YFT2 hom Uncharacterized 0.177898595018364 0.42940130712987 no 1972 0.423663678657242 1414 NA Protein required for normal ER membrane biosynthesis; member of the highly conserved FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; interacts with Sst2p and Hsp82p in high-throughput two-hybrid screens biological_process molecular_function integral to membrane
YNR042W_d YNR042W YNR042W hom Dubious 0.17755921429143 0.429534578875755 no 1973 0.431384014846253 1409 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2 Unknown Unknown Unknown
YDR184C YDR184C ATC1 hom Verified 0.176756385857201 0.429849874293307 no 1974 0.441029648428735 1461 NA FT CELL CYCLE|CELL DIVISION NUCLEUS Nuclear protein; possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding pattern; relative distribution to the nucleus decreases upon DNA replication stress bipolar cellular bud site selection|response to stress molecular_function nucleus
YLL046C YLL046C RNP1 hom Verified 0.175641784330383 0.430287686734764 no 1975 0.412022893753698 1343 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS Ribonucleoprotein that contains two RNA recognition motifs (RRM) ribosome biogenesis RNA binding cytoplasm
YPL265W YPL265W DIP5 hom Verified 0.175315061203232 0.430416038958193 no 1976 0.408401798127068 1362 NA FT PLASMA MEMBRANE Dicarboxylic amino acid permease; mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly; relocalizes from plasma membrane to vacuole upon DNA replication stress amino acid transport amino acid transmembrane transporter activity integral to membrane|plasma membrane
YNL328C YNL328C MDJ2 hom Verified 0.174281280966346 0.430822204867173 no 1977 0.445592621141139 1470 NA FT PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Constituent of the mitochondrial import motor associated with the presequence translocase; function overlaps with that of Pam18p; stimulates the ATPase activity of Ssc1p to drive mitochondrial import; contains a J domain protein import into mitochondrial matrix protein transporter activity|ATPase activator activity mitochondrial inner membrane|presequence translocase-associated import motor
YJR096W YJR096W YJR096W hom Verified 0.174240331015855 0.430838295361027 no 1978 0.439128833484917 1467 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS NUCLEUS Putative xylose and arabinose reductase; member of the aldo-keto reductase (AKR) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS cellular response to oxidative stress|D-xylose catabolic process|arabinose catabolic process alditol:NADP+ 1-oxidoreductase activity|aldo-keto reductase (NADP) activity nucleus|cytoplasm
YPL002C YPL002C SNF8 hom Verified 0.173762368730596 0.431026109913116 no 1979 0.42579108412277 1411 NA FF|FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression negative regulation of transcription from RNA polymerase II promoter by glucose|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein targeting to vacuole molecular_function ESCRT II complex
YMR013W-A_d YMR013W-A YMR013W-A hom Dubious 0.172799672583426 0.431404447206371 no 1980 0.415950718067578 1352 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the characterized snoRNA gene snR73 Unknown Unknown Unknown
YBR158W YBR158W AMN1 hom Verified 0.172620325894581 0.431474936993465 no 1981 0.451342258339965 1501 NA FT CELL CYCLE|CELL DIVISION NUCLEUS Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN) mitotic cell cycle checkpoint|negative regulation of exit from mitosis protein binding nucleus|cellular bud|cytoplasm
YKL040C YKL040C NFU1 hom Verified 0.171435384791724 0.431940716783386 no 1982 0.423097139066345 1393 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS|COFACTOR METABOLISM MITOCHONDRION Protein involved in iron metabolism in mitochondria; similar to NifU, which is a protein required for the maturation of the Fe/S clusters of nitrogenase in nitrogen-fixing bacteria cellular iron ion homeostasis|iron-sulfur cluster assembly|intracellular sequestering of iron ion molecular_function mitochondrion|mitochondrial matrix
YGL017W YGL017W ATE1 hom Verified 0.171258134411837 0.432010398984305 no 1983 0.426017241867348 1428 NA FT PROTEOLYSIS Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway cellular protein modification process|protein arginylation arginyltransferase activity cytoplasm
YCR020C-A YCR020C-A MAK31 hom Verified 0.171183571002502 0.432039712628265 no 1984 0.417255335499831 1394 NA Non-catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus; member of the Sm protein family N-terminal protein amino acid acetylation peptide alpha-N-acetyltransferase activity NatC complex
YFR038W YFR038W IRC5 hom Verified 0.171150960905042 0.432052532985655 no 1985 0.408892010782383 1351 NA FT NUCLEUS Putative ATPase containing the DEAD/H helicase-related sequence motif; null mutant displays increased levels of spontaneous Rad52p foci mitotic recombination molecular_function cellular_component
YDR099W YDR099W BMH2 hom Verified 0.170877363918258 0.432160097920941 no 1986 0.439465151360868 1445 NA FT CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS 14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress glycogen metabolic process|ascospore formation|Ras protein signal transduction|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|DNA damage checkpoint|DNA replication initiation|signal transduction involved in filamentous growth|pseudohyphal growth|fungal-type cell wall chitin biosynthetic process|pre-replicative complex assembly DNA replication origin binding|phosphoserine binding nucleus|plasma membrane
YHL046C YHL046C PAU13 hom Verified 0.170568824266419 0.432281406633715 no 1987 0.424214241080631 1399 NA Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; expression is induced after ethanol shock biological_process molecular_function cellular_component
YGL003C YGL003C CDH1 hom Verified 0.170149844432805 0.432446147395433 no 1988 0.431222423912517 1429 NA FT CELL CYCLE|CELL DIVISION|PROTEOLYSIS|CYTOSKELETON ORGANIZATION NUCLEUS UBIQUITIN LIGASE COMPLEX Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including Cdc20p, Ase1p, Cin8p and Fin1p activation of mitotic anaphase-promoting complex activity|negative regulation of spindle pole body separation|positive regulation of mitotic metaphase/anaphase transition|Unknown|regulation of cell size anaphase-promoting complex binding|cyclin binding|ubiquitin-protein ligase activator activity nucleus|anaphase-promoting complex|cytoplasm
YLR149C YLR149C YLR149C hom Verified 0.169008177756951 0.432895104507151 no 1989 0.450170363345184 1485 NA Protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene; protein abundance increases in response to DNA replication stress biological_process molecular_function cellular_component
YGL258W YGL258W VEL1 hom Verified 0.16827849664033 0.433182094908324 no 1990 0.445164386976464 1479 NA Protein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants; VEL1 has paralog YOR387C biological_process molecular_function cytosol
YHR097C_p YHR097C YHR097C hom Uncharacterized 0.168069107430165 0.43326445615516 no 1991 0.426135883689813 1408 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus biological_process molecular_function nucleus|cytoplasm
YDR203W_d YDR203W YDR203W hom Dubious 0.167907691605363 0.433327949507489 no 1992 0.447781983806359 1481 NA FF Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YNL092W_p YNL092W YNL092W hom Uncharacterized 0.166961767704778 0.433700065777291 no 1993 0.426868980671366 1415 NA Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; YNL092W is not an essential gene biological_process S-adenosylmethionine-dependent methyltransferase activity cellular_component
YGR077C YGR077C PEX8 hom Verified 0.166915070042663 0.433718437659417 no 1994 0.399562963004135 1332 NA FT PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p protein targeting to peroxisome|peroxisome organization peroxisome targeting sequence binding peroxisomal matrix|peroxisomal membrane|extrinsic to intraperoxisomal membrane
YDL025C YDL025C RTK1 hom Verified 0.166656476464949 0.433820176622572 no 1995 0.457459582513125 1529 NA FT PROTEIN PHOSPHORYLATION Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance increases in response to DNA replication stress biological_process protein serine/threonine kinase activity|protein kinase activity cellular_component
YJL189W YJL189W RPL39 hom Verified 0.166653059547418 0.433821520976301 no 1996 0.418256238179444 1385 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YKL101W YKL101W HSL1 hom Verified 0.166159120550823 0.434015864626426 no 1997 0.440880782396214 1460 NA FT CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION SITE OF POLARIZED GROWTH|CYTOSKELETON Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p G2/M transition of mitotic cell cycle|regulation of cell cycle|cell shape checkpoint|protein autophosphorylation|protein phosphorylation|septin checkpoint protein kinase activity cellular bud neck|septin ring
YOL155C YOL155C HPF1 hom Verified 0.166095427030718 0.43404092643617 no 1998 0.435721604635139 1452 NA FT CELL WALL ORG/BIOGENESIS Haze-protective mannoprotein that reduces the particle size of aggregated proteins in white wines fungal-type cell wall organization glucosidase activity fungal-type cell wall|extracellular region
YDR119W_p YDR119W VBA4 hom Uncharacterized 0.165798548308775 0.434157744296635 no 1999 0.418509341927278 1386 NA Protein of unknown function with proposed role as a basic amino acid permease based on phylogeny; GFP-fusion protein localizes to vacuolar membrane; physical interaction with Atg27p suggests a possible role in autophagy; non-essential gene biological_process molecular_function fungal-type vacuole membrane|integral to membrane
YJR047C YJR047C ANB1 hom Verified 0.163414522625567 0.435096034589621 no 2000 0.440085086380614 1459 NA FT KETONE METABOLISM|PROTEIN COMPLEX ORG/BIOGENESIS|AMINO ACID METABOLISM|TRANSLATION RIBOSOME Translation elongation factor eIF-5A; previously thought to function in translation initiation; undergoes an essential hypusination modification; expressed under anaerobic conditions; ANB1 has a paralog, HYP2, that arose from the whole genome duplication translational frameshifting|positive regulation of translational termination|positive regulation of translational elongation ribosome binding|RNA binding|translation elongation factor activity cytosolic ribosome
YGL027C YGL027C CWH41 hom Verified 0.16306850333771 0.435232249257952 no 2001 0.443801620984534 1465 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Processing alpha glucosidase I, ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress fungal-type cell wall biogenesis|protein N-linked glycosylation mannosyl-oligosaccharide glucosidase activity endoplasmic reticulum membrane
YDR020C_p YDR020C DAS2 hom Uncharacterized 0.162549649345262 0.435436516792197 no 2002 0.419409104675808 1393 NA FT NUCLEOTIDE METABOLISM NUCLEUS Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases biological_process molecular_function nucleus|cytoplasm
YDR242W YDR242W AMD2 hom Verified 0.16233418536786 0.435521347832234 no 2003 0.397611152068016 1278 NA Putative amidase biological_process amidase activity cellular_component
YCR008W YCR008W SAT4 hom Verified 0.161873858714303 0.43570259450839 no 2004 0.422214359167106 1396 NA FT PROTEIN LOCALIZATION|CELL CYCLE|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; partially redundant with Hal5p; has similarity to Npr1p cellular cation homeostasis|protein phosphorylation|cellular protein localization|G1/S transition of mitotic cell cycle|protein dephosphorylation protein kinase activity cellular_component
YBR006W YBR006W UGA2 hom Verified 0.1614645061942 0.435863782235057 no 2005 0.484962952908742 1738 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm cellular response to oxidative stress|gamma-aminobutyric acid catabolic process|glutamate decarboxylation to succinate succinate-semialdehyde dehydrogenase [NAD(P)+] activity cytoplasm
YCR053W YCR053W THR4 hom Verified 0.160944876529418 0.436068408323384 no 2006 0.426935077559987 1396 NA FT VESICLE-MEDIATED TRANSPORT|KETONE METABOLISM|MEMBRANE ORGANIZATION|AMINO ACID METABOLISM NUCLEUS Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway endocytosis|threonine metabolic process threonine synthase activity nucleus|cytoplasm
YDR496C YDR496C PUF6 hom Verified 0.16030892312349 0.436318865073012 no 2007 0.420122586042588 1385 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION NUCLEUS|SITE OF POLARIZED GROWTH RIBOSOME Pumilio-homology domain protein that binds the 3' UTR of ASH1 mRNA and represses its translation, resulting in proper asymmetric localization of ASH1 mRNA; also co-sediments with the 60S ribosomal subunit and is required for its biogenesis ribosomal large subunit biogenesis|negative regulation of translation mRNA 3'-UTR binding|translation repressor activity, nucleic acid binding nucleolus|nucleus|large ribosomal subunit
YER061C YER061C CEM1 hom Verified 0.159799643003231 0.436519452654981 no 2008 0.447603123296411 1468 NA FT KETONE METABOLISM|LIPID METABOLISM MITOCHONDRION Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration fatty acid biosynthetic process fatty acid synthase activity mitochondrion
YLR232W_d YLR232W YLR232W hom Dubious 0.159745864526346 0.436540635065176 no 2009 0.430729792544884 1449 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene BNA5 Unknown Unknown Unknown
YKL176C YKL176C LST4 hom Verified 0.159614872727193 0.436592231226428 no 2010 0.452359914940564 1498 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface intracellular protein transport|vesicle-mediated transport|protein transport|Golgi to plasma membrane transport protein transporter activity vesicle coat
YKR102W YKR102W FLO10 hom Verified 0.159306101159691 0.436713857058192 no 2011 0.434478933888405 1435 NA Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth filamentous growth of a population of unicellular organisms|flocculation via cell wall protein-carbohydrate interaction|flocculation|invasive growth in response to glucose limitation mannose binding fungal-type cell wall
YDR183W YDR183W PLP1 hom Verified 0.159176267030282 0.436765000808274 no 2012 0.419350976833019 1356 NA FT TRANSCRIPTION FROM RNA POL II|SIGNALING Protein that interacts with CCT (chaperonin containing TCP-1) complex and has a role in actin and tubulin folding; has weak similarity to phosducins, which are G-protein regulators protein folding|positive regulation of transcription from RNA polymerase II promoter by pheromones G-protein beta/gamma-subunit complex binding cellular_component
YER177W YER177W BMH1 hom Verified 0.158694561915561 0.436954761423138 no 2013 0.4218720269311 1397 NA FT CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS 14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress glycogen metabolic process|pseudohyphal growth|signal transduction involved in filamentous growth|ascospore formation|fungal-type cell wall chitin biosynthetic process|Ras protein signal transduction|DNA damage checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle DNA replication origin binding|phosphoserine binding plasma membrane|nucleus
YLR154C YLR154C RNH203 hom Verified 0.15784560459682 0.437289230905079 no 2014 0.426317187746153 1398 NA FT NUCLEUS Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS3 that causes Aicardi-Goutieres syndrome RNA catabolic process|DNA replication, removal of RNA primer ribonuclease H activity ribonuclease H2 complex|nucleus|cytoplasm
YOR013W_d YOR013W IRC11 hom Dubious 0.157623265451015 0.437376834785039 no 2015 0.421795977659986 1379 NA Dubious opening reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YOR012C; null mutant displays increased levels of spontaneous Rad52 foci Unknown Unknown Unknown
YIL014W YIL014W MNT3 hom Verified 0.156372910826587 0.437869544256536 no 2016 0.420317656646863 1398 NA FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Alpha-1,3-mannosyltransferase, adds the fourth and fifth alpha-1,3-linked mannose residues to O-linked glycans during protein O-glycosylation protein O-linked glycosylation alpha-1,3-mannosyltransferase activity cellular_component
YGR070W YGR070W ROM1 hom Verified 0.15616557292095 0.437951256290357 no 2017 0.446170454874198 1487 NA FT SIGNALING|NUCLEOTIDE METABOLISM GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP small GTPase mediated signal transduction|activation of Rho GTPase activity Rho guanyl-nucleotide exchange factor activity intracellular
YDR007W YDR007W TRP1 hom Verified 0.156101343601805 0.437976569653131 no 2018 0.490886724024808 1634 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA) tryptophan biosynthetic process phosphoribosylanthranilate isomerase activity cytoplasm
YDR512C YDR512C EMI1 hom Verified 0.155830438486449 0.438083338631108 no 2019 0.422445749378338 1405 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|MITOCHONDRION ORGANIZATION Non-essential protein required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation; contains twin cysteine-x9-cysteine motifs ascospore formation|mitochondrial respiratory chain complex assembly|positive regulation of transcription from RNA polymerase II promoter molecular_function cellular_component
YLR097C YLR097C HRT3 hom Verified 0.154663256842735 0.438543399079253 no 2020 0.407883350232575 1348 NA FT PROTEOLYSIS UBIQUITIN LIGASE COMPLEX Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular response to methylmercury ubiquitin-protein ligase activity|protein binding, bridging SCF ubiquitin ligase complex
YJR031C YJR031C GEA1 hom Verified 0.15400176451571 0.438804172150735 no 2021 0.42943362149773 1419 NA FT VESICLE-MEDIATED TRANSPORT|SIGNALING|CYTOSKELETON ORGANIZATION|RESPONSE TO NUTRIENT LEVELS GOLGI APPARATUS Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA1 has a paralog, GEA2, that arose from the whole genome duplication retrograde vesicle-mediated transport, Golgi to ER|ER to Golgi vesicle-mediated transport|macroautophagy|intra-Golgi vesicle-mediated transport|actin cytoskeleton organization ARF guanyl-nucleotide exchange factor activity integral to membrane|Golgi cis cisterna|Golgi-associated vesicle|extrinsic to membrane
YIL077C_p YIL077C YIL077C hom Uncharacterized 0.152591737744169 0.439360120508961 no 2022 0.449332739774649 1500 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) biological_process molecular_function mitochondrion
YOR331C_d YOR331C YOR331C hom Dubious 0.151857309970319 0.439649739706751 no 2023 0.491193280571803 1650 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene VMA4/YOR332W Unknown Unknown Unknown
YBR026C YBR026C ETR1 hom Verified 0.151154703660357 0.439926840449503 no 2024 0.465901422211688 1533 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION 2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family; localized to in mitochondria, where it has a probable role in fatty acid synthesis fatty acid biosynthetic process|aerobic respiration enoyl-[acyl-carrier-protein] reductase activity mitochondrion
YJR137C YJR137C MET5 hom Verified 0.14998737027556 0.440387289799723 no 2025 0.413742320179123 1375 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine fungal-type cell wall organization|sulfate assimilation sulfite reductase (NADPH) activity sulfite reductase complex (NADPH)|cytoplasm
YPR040W YPR040W TIP41 hom Verified 0.149335031763718 0.44064463691818 no 2026 0.447576681320822 1475 NA FT SIGNALING NUCLEUS Protein that interacts with Tap42p, which regulates PP2A; component of the TOR (target of rapamycin) signaling pathway; protein abundance increases in response to DNA replication stress signal transduction molecular_function nucleus|cytoplasm
YDR524C YDR524C AGE1 hom Verified 0.148129207718841 0.44112039964301 no 2027 0.396783617981552 1326 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM GOLGI APPARATUS ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport phospholipid binding|ARF GTPase activator activity endosome|trans-Golgi network|cytoplasm
YOL101C YOL101C IZH4 hom Verified 0.148078289608175 0.44114049146318 no 2028 0.458096040625019 1501 NA FT LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family; expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism; protein increases in abundance and relocalizes from nucleus to ER upon DNA replication stress cellular zinc ion homeostasis|cellular lipid metabolic process metal ion binding integral to membrane|membrane
YDR165W YDR165W TRM82 hom Verified 0.148040050451877 0.441155580383674 no 2029 0.468049188389827 1566 NA FT RNA PROCESSING NUCLEUS Catalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p tRNA methylation tRNA (guanine-N7-)-methyltransferase activity tRNA methyltransferase complex|nucleus
YMR299C YMR299C DYN3 hom Verified 0.146390909338569 0.441806401649436 no 2030 0.442300975151266 1491 NA FT CYTOSKELETON Dynein light intermediate chain (LIC); localizes with dynein, null mutant is defective in nuclear migration nuclear migration along microtubule motor activity cytoplasmic dynein complex|cytoplasmic microtubule
YOR304W YOR304W ISW2 hom Verified 0.146009745286003 0.441956847625939 no 2031 0.423900053598036 1402 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS ATP-dependent DNA translocase involved in chromatin remodeling; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth negative regulation of transcription from RNA polymerase II promoter by pheromones|nucleosome positioning|termination of RNA polymerase II transcription|negative regulation of antisense RNA transcription|chromatin silencing at rDNA|chromatin remodeling|chromatin silencing at telomere single-stranded DNA binding|DNA translocase activity chromatin accessibility complex|nucleus
YGL231C YGL231C EMC4 hom Verified 0.145988924983215 0.441965065669491 no 2032 0.45275975413281 1487 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm ZK616.6/EMC-4, fly CG11137, human TMM85 protein folding in endoplasmic reticulum molecular_function ER membrane protein complex|endoplasmic reticulum
YKL002W YKL002W DID4 hom Verified 0.145358838713929 0.442213780692732 no 2033 0.437314407633199 1442 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT Class E Vps protein of the ESCRT-III complex, required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis protein retention in Golgi apparatus|intralumenal vesicle formation|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|late endosome to vacuole transport molecular_function ESCRT III complex|cytoplasm
YOL086W-A YOL086W-A MHF1 hom Verified 0.145356603520678 0.442214663034967 no 2034 0.43421390388198 1453 NA FT RESPONSE TO DNA DAMAGE Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM, a Fanconi anemia complementation group protein, to stabilize and remodel blocked replication forks and repair damaged DNA; mhf1 srs2 double mutants are MMS hypersensitive; ortholog of human centromere constitutive-associated network (CCAN) subunit CENP-S, also known as MHF1 response to DNA damage stimulus molecular_function cellular_component
YLR377C YLR377C FBP1 hom Verified 0.144889740459661 0.442398963442113 no 2035 0.443260214075328 1483 NA FT CARBOHYDRATE METABOLISM Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism; undergoes either proteasome-mediated or autophagy-mediated degradation depending on growth conditions; interacts with Vid30p gluconeogenesis|reactive oxygen species metabolic process fructose 1,6-bisphosphate 1-phosphatase activity cytosol
YBR119W YBR119W MUD1 hom Verified 0.144638683200575 0.442498076793897 no 2036 0.460267389935201 1544 NA FT RNA PROCESSING NUCLEUS U1 snRNP A protein, homolog of human U1-A; involved in nuclear mRNA splicing mRNA splicing, via spliceosome U1 snRNA binding|RNA binding U1 snRNP|U2-type prespliceosome
YML019W YML019W OST6 hom Verified 0.144373141593071 0.442602912249 no 2037 0.454650984739098 1502 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p protein N-linked glycosylation via asparagine|protein complex assembly dolichyl-diphosphooligosaccharide-protein glycotransferase activity oligosaccharyltransferase complex|integral to membrane
YHR007C-A_p YHR007C-A YHR007C-A hom Uncharacterized 0.143553287938053 0.442926614653995 no 2038 0.437146919835794 1440 NA Putative protein of unknown function; identified by expression profiling and mass spectrometry biological_process molecular_function cellular_component
YIL093C YIL093C RSM25 hom Verified 0.143442287374862 0.442970443883445 no 2039 0.434529228547426 1443 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YBL093C YBL093C ROX3 hom Verified 0.143245204677795 0.443048264872202 no 2040 0.452052370959099 1499 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme negative regulation of transcription from RNA polymerase II promoter|transcriptional open complex formation at RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription factor recruiting transcription factor activity core mediator complex|nucleus
YBR259W YBR259W YBR259W hom Verified 0.143062547241334 0.443120391797329 no 2041 0.443947983149062 1462 NA Protein of unknown function; YBR259W is not an essential gene; forms cytoplasmic foci upon DNA replication stress biological_process molecular_function cellular_component
YHR183W YHR183W GND1 hom Verified 0.142159303386123 0.443477088219698 no 2042 0.427247009961138 1409 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS MITOCHONDRION 6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress; GND1 has a paralog, GND2, that arose from the whole genome duplication cellular response to oxidative stress|pentose-phosphate shunt, oxidative branch phosphogluconate dehydrogenase (decarboxylating) activity mitochondrion|cytoplasm
YFR012W-A_p YFR012W-A YFR012W-A hom Uncharacterized 0.141951545321354 0.44355913961688 no 2043 0.43289572900086 1426 NA Putative protein of unknown function; identified by homology biological_process molecular_function cellular_component
YBR062C_p YBR062C YBR062C hom Uncharacterized 0.141551873296353 0.443716991786543 no 2044 0.443466544849311 1471 NA Protein of unknown function that interacts with Msb2p; may play a role in activation of the filamentous growth pathway. biological_process molecular_function cellular_component
YCR011C YCR011C ADP1 hom Verified 0.141310633648369 0.443812274737318 no 2045 0.430513778346935 1435 NA FT NUCLEOTIDE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Putative ATP-dependent permease of the ABC transporter family of proteins transport|transmembrane transport ATPase activity, coupled to transmembrane movement of substances integral to membrane|endoplasmic reticulum|cytoplasm
YCR020C YCR020C PET18 hom Verified 0.14126520987358 0.443830216228434 no 2046 0.464071095578451 1547 NA Protein of unknown function, has weak similarity to proteins involved in thiamin metabolism; expression is induced in the absence of thiamin thiamine metabolic process molecular_function cytosol
YER060W-A YER060W-A FCY22 hom Verified 0.139125914210159 0.444675325391981 no 2047 0.420896581397175 1365 NA Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function transmembrane transport nucleobase transmembrane transporter activity integral to membrane
YLR080W YLR080W EMP46 hom Verified 0.138937820067341 0.444749642347745 no 2048 0.423646026153359 1379 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport ER to Golgi vesicle-mediated transport glycoprotein binding ER to Golgi transport vesicle|Golgi membrane
YPL088W_p YPL088W YPL088W hom Uncharacterized 0.138911936696568 0.44475986915171 no 2049 0.440227800655766 1435 NA FT OXIDATION-REDUCTION PROCESS Putative aryl alcohol dehydrogenase; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance cellular aldehyde metabolic process aryl-alcohol dehydrogenase (NAD+) activity cellular_component
YHR037W YHR037W PUT2 hom Verified 0.138283814538313 0.445008058369989 no 2050 0.453370569341545 1500 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION Delta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism glutamate biosynthetic process|proline catabolic process to glutamate 1-pyrroline-5-carboxylate dehydrogenase activity mitochondrion|mitochondrial matrix
YOL068C YOL068C HST1 hom Verified 0.138252842725352 0.445020296786919 no 2051 0.447920897478719 1494 NA FT CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME NAD(+)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing and mitotic repression; non-essential subunit of the Set3C deacetylase complex; involved in telomere maintenance chromatin silencing|negative regulation of mitotic recombination|histone deacetylation NAD-independent histone deacetylase activity|NAD-dependent histone deacetylase activity Set3 complex
YBR232C_d YBR232C YBR232C hom Dubious 0.137158537678697 0.445452741622076 no 2052 0.443615899974342 1470 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YKL017C YKL017C HCS1 hom Verified 0.136771300738382 0.44560578455979 no 2053 0.392970990081908 1276 NA FT NUCLEUS|CHROMOSOME Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities lagging strand elongation ATP-dependent 5'-3' DNA helicase activity DNA helicase A complex|alpha DNA polymerase:primase complex
YER047C YER047C SAP1 hom Verified 0.136467724624285 0.445725768917787 no 2054 0.463744013781336 1530 NA Putative ATPase of the AAA family, interacts with the Sin1p transcriptional repressor in the two-hybrid system biological_process ATPase activity cytoplasm
YOR345C_d YOR345C YOR345C hom Dubious 0.136010722849256 0.445906402066203 no 2055 0.437062595500166 1422 NA Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2 Unknown Unknown Unknown
YPL247C_p YPL247C YPL247C hom Uncharacterized 0.135555858331158 0.446086201598272 no 2056 0.424821830276551 1376 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; overexpression causes a cell cycle delay or arrest biological_process molecular_function nucleus|cytoplasm
YLR202C_d YLR202C YLR202C hom Dubious 0.134368318499493 0.44655566629583 no 2057 0.450251761647906 1484 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron Unknown Unknown Unknown
YDL130W-A YDL130W-A STF1 hom Verified 0.133991278124634 0.446704735645049 no 2058 0.455533469078834 1517 NA FT NUCLEOTIDE METABOLISM MITOCHONDRION Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p act as stabilizing factors that enhance inhibitory action of the Inh1p protein; protein abundance increases in response to DNA replication stress negative regulation of ATPase activity molecular_function mitochondrion|mitochondrial proton-transporting ATP synthase complex
YMR011W YMR011W HXT2 hom Verified 0.133942328250058 0.446724089366446 no 2059 0.445860998259695 1465 NA FT PLASMA MEMBRANE High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose glucose transport pentose transmembrane transporter activity|mannose transmembrane transporter activity|fructose transmembrane transporter activity|glucose transmembrane transporter activity integral to membrane|plasma membrane
YBL081W_p YBL081W YBL081W hom Uncharacterized 0.133920341995391 0.446732782297177 no 2060 0.440125194745078 1438 NA Non-essential protein of unknown function; null mutation results in a decrease in plasma membrane electron transport biological_process molecular_function cellular_component
YPL107W_p YPL107W YPL107W hom Uncharacterized 0.133897818315318 0.446741687741838 no 2061 0.42798602046407 1405 NA FT MITOCHONDRION Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YPL107W is not an essential gene biological_process molecular_function mitochondrion
YNL146W_p YNL146W YNL146W hom Uncharacterized 0.133818930045798 0.446772878909778 no 2062 0.458461331106434 1507 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNL146W is not an essential gene biological_process molecular_function endoplasmic reticulum
YKL202W_d YKL202W YKL202W hom Dubious 0.133498206529685 0.446899691279164 no 2063 0.4236693848009 1405 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR046C_p YLR046C YLR046C hom Uncharacterized 0.132550572745401 0.447274412302014 no 2064 0.431809080582558 1421 NA Putative membrane protein; member of the fungal lipid-translocating exporter (LTE) family of proteins; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance biological_process molecular_function integral to membrane
YER049W YER049W TPA1 hom Verified 0.132340892812351 0.447357332010226 no 2065 0.451845244599312 1478 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|OXIDATION-REDUCTION PROCESS NUCLEUS Poly(rA)-binding protein involved in translation termination efficiency, mRNA poly(A) tail length and mRNA stability; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; similar to prolyl 4-hydroxylases; binds Fe(III) and 2-oxoglutarate nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|translational termination poly(A) RNA binding nucleus
YIL114C YIL114C POR2 hom Verified 0.131998924261907 0.447492571309261 no 2066 0.444470312924669 1469 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Putative mitochondrial porin (voltage-dependent anion channel); not required for mitochondrial membrane permeability or mitochondrial osmotic stability; POR2 has a paralog, POR1, that arose from the whole genome duplication DNA transport|ion transport|cell redox homeostasis voltage-gated anion channel activity mitochondrial outer membrane|mitochondrion|integral to membrane
YMR016C YMR016C SOK2 hom Verified 0.131667427105673 0.447623675282901 no 2067 0.423341581580047 1396 NA FT NUCLEUS Nuclear protein that negatively regulates pseudohyphal differentiation; plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; SOK2 has a paralog, PHD1, that arose from the whole genome duplication pseudohyphal growth sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nucleus
YMR316C-A_p YMR316C-A YMR316C-A hom Uncharacterized 0.130866572545276 0.44794042923177 no 2068 0.452252564784528 1512 NA Protein of unknown function; mRNA identified as translated by ribosome profiling data; overlaps the verified gene DIA1/YMR316W biological_process molecular_function cellular_component
YNL081C YNL081C SWS2 hom Verified 0.130500620276713 0.448085181714949 no 2069 0.462070332766393 1542 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency regulation of sporulation resulting in formation of a cellular spore|mitochondrial translation structural constituent of ribosome mitochondrial small ribosomal subunit|cytoplasm
YJR038C_d YJR038C YJR038C hom Dubious 0.12978257676072 0.448369224023913 no 2070 0.448048446473323 1498 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR314C YDR314C RAD34 hom Verified 0.129710608478717 0.448397694564004 no 2071 0.473495027438373 1578 NA FT RESPONSE TO DNA DAMAGE NUCLEUS Protein involved in nucleotide excision repair (NER); homologous to RAD4 nucleotide-excision repair molecular_function nucleus
YHR207C YHR207C SET5 hom Verified 0.129209011003164 0.448596133116271 no 2072 0.453078607912472 1501 NA FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Methyltransferase involved in methylation of histone H4 Lys5, -8, -12; S-adenosylmethionine-dependent; zinc-finger protein, contains one canonical and two unusual fingers in unusual arrangements; deletion enhances replication of positive-strand RNA virus histone lysine methylation S-adenosylmethionine-dependent methyltransferase activity nuclear chromatin|nucleus|cytoplasm
YDR148C YDR148C KGD2 hom Verified 0.129077825348217 0.448648034008851 no 2073 0.452172470659378 1496 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated tricarboxylic acid cycle|mitochondrial genome maintenance|2-oxoglutarate metabolic process dihydrolipoyllysine-residue succinyltransferase activity mitochondrial nucleoid|mitochondrion|mitochondrial oxoglutarate dehydrogenase complex
YHR138C YHR138C YHR138C hom Verified 0.128824593830656 0.448748222308955 no 2074 0.455021565049756 1485 NA FT MEMBRANE ORGANIZATION Protein of unknown function; similar to Pbi2p; double null mutant lacking Pbi2p and Yhr138cp exhibits highly fragmented vacuoles; protein abundance increases in response to DNA replication stress vacuole fusion, non-autophagic endopeptidase inhibitor activity cellular_component
YDR100W YDR100W TVP15 hom Verified 0.127887464831066 0.449119015600403 no 2075 0.457521526677086 1528 NA FT VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p vesicle-mediated transport molecular_function COPI-coated vesicle|integral to membrane|integral to Golgi membrane
YML029W YML029W USA1 hom Verified 0.127469473658543 0.449284416277755 no 2076 0.440972249645125 1445 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|PROTEOLYSIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM UBIQUITIN LIGASE COMPLEX Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p ER-associated protein catabolic process|mRNA splicing, via spliceosome|positive regulation of protein oligomerization protein complex scaffold Hrd1p ubiquitin ligase ERAD-L complex|endoplasmic reticulum membrane
YMR271C YMR271C URA10 hom Verified 0.127316750673045 0.449344851536663 no 2077 0.434897214832785 1437 NA FT NUCLEOTIDE METABOLISM Minor orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA10 has a paralog, URA5, that arose from the whole genome duplication 'de novo' pyrimidine nucleobase biosynthetic process|pyrimidine ribonucleoside biosynthetic process orotate phosphoribosyltransferase activity cytoplasm
YGR063C YGR063C SPT4 hom Verified 0.126963876964372 0.449484494563655 no 2078 0.484731912563446 1614 NA FF|FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION|CHROMOSOME SEGREGATION|GENE SILENCING NUCLEUS|CHROMOSOME Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair; Spt4p also localizes to kinetochores and heterochromatin and affects chromosome dynamics and silencing; required for transcription through lengthy trinucleotide repeats in ORFs or non-protein coding regions 7-methylguanosine mRNA capping|chromosome segregation|chromatin organization|intracellular mRNA localization|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription, DNA-dependent|regulation of transcription-coupled nucleotide-excision repair|chromatin silencing|mRNA splicing, via spliceosome|Unknown core RNA polymerase I binding transcription factor activity|core RNA polymerase II binding transcription factor activity|rDNA binding DSIF complex|nuclear telomeric heterochromatin|rDNA heterochromatin|mating-type region heterochromatin|kinetochore
YHR178W YHR178W STB5 hom Verified 0.126711256322601 0.449584468198915 no 2079 0.43631555234129 1444 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO OXIDATIVE STRESS NUCLEUS Transcription factor, involved in regulating multidrug resistance and oxidative stress response; forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that interacts with a pleiotropic drug resistance element in vitro response to xenobiotic stimulus|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|transcription, DNA-dependent sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nucleus
YOR199W_d YOR199W YOR199W hom Dubious 0.12665875127151 0.449605247270322 no 2080 0.467145583193488 1545 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPL031C YPL031C PHO85 hom Verified 0.124855378074139 0.450319022495751 no 2081 0.484352010573897 1608 NA FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES A NUCLEUS Cyclin-dependent kinase, with ten cyclin partners; involved in regulating the cellular response to nutrient levels and environmental conditions and progression through the cell cycle regulation of transcription involved in G1/S phase of mitotic cell cycle|negative regulation of calcium-mediated signaling|regulation of protein stability|regulation of protein localization|protein phosphorylation|response to DNA damage stimulus|negative regulation of phosphate metabolic process|fungal-type cell wall organization|regulation of establishment or maintenance of cell polarity|negative regulation of glycogen biosynthetic process|negative regulation of transcription from RNA polymerase II promoter|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of macroautophagy|negative regulation of macroautophagy protein kinase activity|cyclin-dependent protein kinase activity cyclin-dependent protein kinase holoenzyme complex|nucleus
YMR098C YMR098C ATP25 hom Verified 0.124655115040427 0.45039829657458 no 2082 0.455445987054047 1516 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial protein required for the stability of Oli1p (Atp