strainid orf gene zyg qualifier SGTC_2695|st077686.score SGTC_2695|st077686.expt.zyg.pval SGTC_2695|st077686.expt.zyg.significant SGTC_2695|st077686.expt.zyg.rank strain.pval strain.rank clearance Fclass Fterms.BP Fterms.CC Fterms.complex description GO_process GO_function GO_component
YMR277W YMR277W FCP1 het Verified 5.15310603528069 1.28103498517802e-07 yes 1 6.32258507173944e-06 26 1.055 FF|FT TRANSCRIPTION FROM RNA POL II NUCLEUS Carboxy-terminal domain (CTD) phosphatase, essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p) dephosphorylation of RNA polymerase II C-terminal domain|regulation of transcription from RNA polymerase II promoter protein serine/threonine phosphatase activity nucleus
YNL188W YNL188W KAR1 het Verified 4.09831745295712 2.08082129998998e-05 yes 2 2.21082535612263e-05 6 0.010 FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION NUCLEUS|CYTOSKELETON Essential protein involved in karyogamy during mating and in spindle pole body duplication during mitosis, localizes to the half-bridge of the spindle pole body, interacts with Spc72p during karyogamy, also interacts with Cdc31p karyogamy involved in conjugation with cellular fusion|spindle pole body duplication associated with nuclear envelope protein binding half bridge of spindle pole body
YJL195C_d YJL195C YJL195C het Dubious 4.08847906988209 2.1710535758004e-05 yes 3 0.000136544475751622 52 0.659 FF Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL194W/CDC6 Unknown Unknown Unknown
YBR142W YBR142W MAK5 het Verified 3.4289878484778 0.000302918325783518 yes 4 0.000200324737310017 22 0.061 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Essential nucleolar protein, putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunits maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal large subunit biogenesis|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ATP-dependent RNA helicase activity nucleolus
YGL065C YGL065C ALG2 het Verified 3.36831916049736 0.000378139961972257 yes 5 0.000258866700788669 21 0.024 FT LIPID METABOLISM|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Mannosyltransferase that catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol oligosaccharide-lipid intermediate biosynthetic process GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity|glycolipid 6-alpha-mannosyltransferase activity integral to membrane|endoplasmic reticulum
YIL144W YIL144W TID3 het Verified 3.34393530991864 0.000412994977194009 yes 6 0.000625151257456931 45 0.001 FT PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME KINETOCHORE Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint activity, kinetochore assembly and clustering microtubule nucleation|chromosome segregation|protein localization to kinetochore structural constituent of cytoskeleton Ndc80 complex|condensed nuclear chromosome kinetochore|condensed nuclear chromosome, centromeric region
YBR123C YBR123C TFC1 het Verified 3.34255443305992 0.000415055362735305 yes 7 0.00122852666075421 48 0.003 FT NUCLEUS One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes; human homolog is TFIIIC-63 transcription from a RNA polymerase III hybrid type promoter|transcription from RNA polymerase III type 2 promoter|5S class rRNA transcription from RNA polymerase III type 1 promoter RNA polymerase III type 1 promoter sequence-specific DNA binding|RNA polymerase III type 2 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity|RNA polymerase III type 2 promoter sequence-specific DNA binding|RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity|DNA binding, bending transcription factor TFIIIC complex
YKL112W YKL112W ABF1 het Verified 3.33933997138548 0.000419888602099128 yes 8 0.00144885604616172 47 0.316 FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING NUCLEUS DNA binding protein with possible chromatin-reorganizing activity involved in transcriptional activation, gene silencing, and DNA replication and repair negative regulation of transcription from RNA polymerase II promoter|global genome nucleotide-excision repair|chromatin remodeling|DNA-dependent DNA replication|positive regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette DNA replication origin binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding, bending nucleotide-excision repair factor 4 complex|nucleus
YML023C YML023C NSE5 het Verified 3.02352349007399 0.00124924815661624 no 9 0.000344122559128856 13 0.037 FT RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair DNA repair molecular_function Smc5-Smc6 complex|nucleus
YLR208W YLR208W SEC13 het Verified 2.98625535251592 0.00141208355461349 no 10 0.0194369064966993 294 0.183 FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM NUCLEAR PORE Structural component of 3 distinct complexes; subunit of Nup84 nuclear pore sub-complex (NPC), COPII vesicle coat, and Seh1-associated (SEA) complex; COPII vesicle coat is required for ER to Golgi transport; the Nup84 subcomplex contributes to nucleocytoplasmic transport, NPC biogenesis and processes that may require localization of chromosomes at the nuclear periphery, including transcription; homologous to human SEC13; abundance increases under DNA replication stress positive regulation of transcription, DNA-dependent|ER-associated protein catabolic process|positive regulation of GTPase activity|nuclear pore distribution|COPII-coated vesicle budding structural molecule activity COPII vesicle coat|nuclear pore outer ring|Seh1-associated complex
YLR310C YLR310C CDC25 het Verified 2.80374800616682 0.00252561836465198 no 11 0.00618835722322854 86 0.063 FT CELL CYCLE|SIGNALING|CELL DIVISION NUCLEUS|PLASMA MEMBRANE Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor); indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1 regulation of cell cycle|replicative cell aging|Ras protein signal transduction|traversing start control point of mitotic cell cycle Ras guanyl-nucleotide exchange factor activity cytosol|nucleus|plasma membrane|cytoplasm
YMR128W YMR128W ECM16 het Verified 2.74107088649929 0.00306196470199172 no 12 0.00202212137994938 58 0.042 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS|MITOCHONDRION Essential DEAH-box ATP-dependent RNA helicase specific to the U3 snoRNP, predominantly nucleolar in distribution, required for 18S rRNA synthesis maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosome biogenesis RNA helicase activity small-subunit processome|mitochondrion|nucleolus|90S preribosome
YKL006C-A YKL006C-A SFT1 het Verified 2.69904557459097 0.0034769326326874 no 13 0.00200836158350949 44 0.011 FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Intra-Golgi v-SNARE, required for transport of proteins between an early and a later Golgi compartment intra-Golgi vesicle-mediated transport|vesicle fusion SNAP receptor activity SNARE complex|Golgi membrane
YDR381W YDR381W YRA1 het Verified 2.68846707260734 0.00358904573213329 no 14 0.00354808232820859 58 0.008 FT RESPONSE TO DNA DAMAGE|RNA LOCALIZATION NUCLEUS RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member mRNA export from nucleus|transcription-coupled nucleotide-excision repair RNA binding transcription export complex
YDR341C YDR341C YDR341C het Verified 2.68042740851599 0.00367641051584969 no 15 0.00663679638188335 36 0.005 FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION MITOCHONDRION Arginyl-tRNA synthetase, proposed to be cytoplasmic but the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies cytoplasmic translation|arginyl-tRNA aminoacylation arginine-tRNA ligase activity mitochondrion|cytoplasm
YPR133C YPR133C SPN1 het Verified 2.67523134951259 0.00373388488246175 no 16 0.0199797345668197 139 0.040 FF|FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RNA LOCALIZATION NUCLEUS Protein involved in RNA polymerase II transcription; interacts genetically or physically with RNAP II, TBP, TFIIS, and chromatin remodelling factors; central domain highly conserved throughout eukaryotes; mutations confer an Spt- phenotype poly(A)+ mRNA export from nucleus|regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription by chromatin organization|regulation of transcription from RNA polymerase II promoter core RNA polymerase II binding transcription factor activity|RNA polymerase II transcription factor binding transcription factor activity nucleus
YHR062C YHR062C RPP1 het Verified 2.63498780852575 0.00420701526001142 no 17 0.120046988458939 548 0.019 FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs tRNA processing|intronic box C/D snoRNA processing|mRNA cleavage|rRNA processing ribonuclease MRP activity|ribonuclease P activity nucleolar ribonuclease P complex|ribonuclease MRP complex
YPR181C YPR181C SEC23 het Verified 2.61604812189411 0.00444770099439316 no 18 0.0257725026389655 174 0.020 FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS GTPase-activating protein, stimulates the GTPase activity of Sar1p; component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, involved in ER to Golgi transport; substrate of Ubp3/Bre5 complex; ubiquitylated by Ub-ligase Rsp5p; proteasome-mediated degradation of Sec23p is regulated by Cdc48p regulation of COPII vesicle coating GTPase activator activity COPII vesicle coat
YHR020W YHR020W YHR020W het Verified 2.59584527917814 0.00471792721041057 no 19 0.0022248986490912 46 0.060 FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION Prolyl-tRNA synthetase; N-terminal domain shows weak homology to prokaryotic posttransfer editing domain, but does not possess posttransfer editing activity; may interact with ribosomes, based on co-purification experiments chromosome organization|tRNA aminoacylation for protein translation proline-tRNA ligase activity ribosome
YBR060C YBR060C ORC2 het Verified 2.53550923341749 0.00561419841710609 no 20 0.00397244347779332 61 0.007 FT CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; interacts with Spp1p and with trimethylated histone H3; phosphorylated by Cdc28p histone H3-K4 methylation|DNA replication initiation|pre-replicative complex assembly|chromatin silencing at silent mating-type cassette|chromatin silencing at telomere chromatin binding|DNA replication origin binding DNA replication preinitiation complex|pre-replicative complex|nuclear origin of replication recognition complex
YDL029W YDL029W ARP2 het Verified 2.52816223872898 0.00573306766837369 no 21 0.0105115650009113 80 0.069 FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL WALL ORG/BIOGENESIS|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|VACUOLAR TRANSPORT MITOCHONDRION|CYTOSKELETON Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity mitochondrion inheritance|Arp2/3 complex-mediated actin nucleation|ascospore wall assembly|actin filament organization|establishment of mitochondrion localization|ATP catabolic process|CVT pathway ATPase activity|ATP binding Arp2/3 protein complex|mitochondrion
YDL195W YDL195W SEC31 het Verified 2.45933957791056 0.00695964449017256 no 22 0.0357003466402229 341 0.001 FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance COPII-coated vesicle budding structural molecule activity COPII vesicle coat|mating projection tip
YIL068C YIL068C SEC6 het Verified 2.458005378872 0.0069855540778981 no 23 0.00652899563925779 84 0.109 FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION SITE OF POLARIZED GROWTH Essential 88kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; anchors the assembled complex to sites of secretion; interacts with SM-like protein and SNARE regulator Sec1p and may recruit it to sites of secretion; interacts with Sec9p and inhibits formation of the t-SNARE complex between Sec9p and Sso1p exocyst localization|Golgi to plasma membrane transport|exocytosis|vesicle fusion|negative regulation of SNARE complex assembly|vesicle docking involved in exocytosis protein homodimerization activity mating projection tip|cellular bud neck|cellular bud tip|exocyst
YGL011C YGL011C SCL1 het Verified 2.34902207866488 0.00941139532531887 no 24 0.0253800555364197 138 0.013 FT PROTEOLYSIS ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION Alpha 1 subunit of the 20S proteasome involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process molecular_function mitochondrion|proteasome core complex, alpha-subunit complex|nucleus|proteasome storage granule|nuclear outer membrane-endoplasmic reticulum membrane network
YOR353C YOR353C SOG2 het Verified 2.33553054902514 0.00975786096828701 no 25 0.0121101622048996 52 0.061 FT CELL CYCLE|SIGNALING|CELL DIVISION SITE OF POLARIZED GROWTH Key component of the RAM signaling network, required for proper cell morphogenesis and cell separation after mitosis signal transduction|cytokinetic cell separation|budding cell apical bud growth molecular_function incipient cellular bud site|cellular bud|mating projection tip|cytoplasm
YKL033W YKL033W TTI1 het Verified 2.27498308275295 0.011453472345281 no 26 0.0149879935961089 38 0.015 FT CHROMATIN ORGANIZATION NUCLEUS|MITOCHONDRION|CHROMOSOME Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1; similar to S. pombe Tti1p; detected in highly purified mitochondria in high-throughput studies biological_process molecular_function ASTRA complex|mitochondrion|cytoplasm
YPL016W YPL016W SWI1 het Verified 2.25984188262131 0.0119155329830996 no 27 0.0234229396453931 136 0.094 FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS NUCLEUS RSC COMPLEX Subunit of the SWI/SNF chromatin remodeling complex; regulates transcription by remodeling chromatin; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; can form the prion [SWI+]; human homolog ARID1A is a candidate tumor suppressor gene in breast cancer cellular alcohol catabolic process|ATP-dependent chromatin remodeling|positive regulation of mating type switching|sucrose catabolic process|carbon catabolite activation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation|positive regulation of transcription from RNA polymerase II promoter|DNA-dependent DNA replication RNA polymerase II activating transcription factor binding SWI/SNF complex|nucleus
YGL068W YGL068W MNP1 het Verified 2.16603351832301 0.015154312855623 no 28 0.0160713610035169 128 0.012 FT TRANSLATION|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Protein associated with the mitochondrial nucleoid; putative mitochondrial ribosomal protein with similarity to E. coli L7/L12 ribosomal protein; required for normal respiratory growth aerobic respiration structural constituent of ribosome mitochondrial nucleoid|mitochondrion
YGL111W YGL111W NSA1 het Verified 2.15405257390087 0.0156180245972624 no 29 0.01418732936382 113 0.009 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis ribosomal large subunit biogenesis molecular_function nucleolus|nucleus|preribosome, large subunit precursor
YPR086W YPR086W SUA7 het Verified 2.14536737434508 0.015961742756657 no 30 0.0184625671975786 103 0.011 FT TRANSCRIPTION FROM RNA POL II|TRANSLATION NUCLEUS Transcription factor TFIIB, a general transcription factor required for transcription initiation and start site selection by RNA polymerase II transcriptional start site selection at RNA polymerase II promoter|transcriptional open complex formation at RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|Unknown TBP-class protein binding|RNA polymerase II core binding|TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly|core RNA polymerase II recruiting transcription factor activity nucleus
YMR298W YMR298W LIP1 het Verified 2.13467322916839 0.016393855601704 no 31 0.0107573569103838 85 0.005 FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Ceramide synthase subunit; single-span ER membrane protein associated with Lag1p and Lac1p and required for ceramide synthase activity, null mutant grows extremely slowly and is defective in ceramide synthesis ceramide biosynthetic process sphingosine N-acyltransferase activity nuclear envelope|endoplasmic reticulum|endoplasmic reticulum membrane
YBR140C YBR140C IRA1 het Verified 2.12964702209504 0.0166003829243052 no 32 0.0705011474067744 345 0.009 FF|FT SIGNALING|NUCLEOTIDE METABOLISM MITOCHONDRION|PLASMA MEMBRANE GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase; IRA1 has a paralog, IRA2, that arose from the whole genome duplication negative regulation of cAMP biosynthetic process|negative regulation of Ras protein signal transduction|regulation of adenylate cyclase activity|positive regulation of Ras GTPase activity Ras GTPase activator activity mitochondrion|integral to membrane|membrane
YHR101C YHR101C BIG1 het Verified 2.12093153071498 0.0169637823890146 no 33 0.00933475754634492 92 0.013 FT CELL WALL ORG/BIOGENESIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Integral membrane protein of the endoplasmic reticulum, required for normal content of cell wall beta-1,6-glucan fungal-type cell wall biogenesis molecular_function integral to endoplasmic reticulum membrane
YNL221C YNL221C POP1 het Verified 2.10801904747905 0.0175146709396146 no 34 0.0172770837377564 183 0.005 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P tRNA processing|intronic box C/D snoRNA processing|mRNA cleavage|rRNA processing ribonuclease MRP activity|ribonuclease P activity nucleolar ribonuclease P complex|ribonuclease MRP complex
YFL017C YFL017C GNA1 het Verified 2.10270602800713 0.0177457374026248 no 35 0.0150235187610924 126 0.018 FT CARBOHYDRATE METABOLISM NUCLEUS Evolutionarily conserved glucosamine-6-phosphate acetyltransferase required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA UDP-N-acetylglucosamine biosynthetic process glucosamine 6-phosphate N-acetyltransferase activity nucleus|cytoplasm
YAL041W YAL041W CDC24 het Verified 2.08435662098469 0.018563870275109 no 36 0.0254832275463829 185 0.008 FT CELL CYCLE|SIGNALING NUCLEUS|SITE OF POLARIZED GROWTH Guanine nucleotide exchange factor for Cdc42p; also known as a GEF or GDP-release factor; required for polarity establishment and maintenance, and mutants have morphological defects in bud formation and shmooing; relocalizes from nucleus to cytoplasm upon DNA replication stress regulation of exit from mitosis|establishment of cell polarity|small GTPase mediated signal transduction Rho guanyl-nucleotide exchange factor activity incipient cellular bud site|nucleus|cellular bud neck|mating projection tip|cellular bud tip|cytoplasm
YBR252W YBR252W DUT1 het Verified 2.0759359715524 0.0189499366164048 no 37 0.0208661891715917 180 0.000 FT NUCLEOTIDE METABOLISM NUCLEUS deoxyuridine triphosphate diphosphatase (dUTPase); catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability; also has diphosphatase activity on deoxyinosine triphosphate pyrimidine deoxyribonucleoside triphosphate catabolic process|dUTP catabolic process|dITP catabolic process dITP diphosphatase activity|dUTP diphosphatase activity nucleus|cytoplasm
YDL015C YDL015C TSC13 het Verified 2.07546549969805 0.0189717065725738 no 38 0.019337733982948 111 0.036 FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION Enoyl reductase; catalyzes the last step in each cycle of very long chain fatty acid elongation; localizes to the ER, highly enriched in a structure marking nuclear-vacuolar junctions; coimmunoprecipitates with elongases Fen1p and Sur4p; protein increases in abundance and relative distribution to ER foci increases upon DNA replication stress very long-chain fatty acid metabolic process oxidoreductase activity mitochondrion|integral to membrane|endoplasmic reticulum membrane
YCL052C YCL052C PBN1 het Verified 2.03966794435559 0.0206917048680805 no 39 0.0234560436634317 163 0.037 FT LIPID METABOLISM|PROTEOLYSIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Essential component of glycosylphosphatidylinositol-mannosyltransferase I, required for the autocatalytic post-translational processing of the protease B precursor Prb1p, localizes to ER in lumenal orientation; homolog of mammalian PIG-X GPI anchor biosynthetic process|ER-associated protein catabolic process|protein processing mannosyltransferase activity endoplasmic reticulum
YJR057W YJR057W CDC8 het Verified 2.00290085344526 0.0225939657396232 no 40 0.0168060078764052 117 0.010 FT NUCLEOTIDE METABOLISM NUCLEUS Thymidylate and uridylate kinase, functions in de novo biosynthesis of pyrimidine deoxyribonucleotides; converts dTMP to dTDP and dUMP to dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe Tmp1p dTDP biosynthetic process|dTTP biosynthetic process|dUDP biosynthetic process uridylate kinase activity|thymidylate kinase activity nucleus|cytoplasm
YLR424W YLR424W SPP382 het Verified 1.99268987907921 0.0231477081623991 no 41 0.0342565921494664 186 0.002 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING NUCLEUS|MITOCHONDRION Essential protein that forms a dimer with Ntr2p; also forms a trimer, with Ntr2p and Prp43p, that is involved in spliceosome disassembly; found also in a multisubunit complex with the splicing factor Clf1p; suppressor of prp38-1 mutation spliceosomal complex disassembly|mRNA splicing, via spliceosome|generation of catalytic spliceosome for first transesterification step RNA binding|ATP-dependent RNA helicase activity mitochondrion|U2-type post-mRNA release spliceosomal complex|nucleus|spliceosomal complex|cytoplasm
YLR166C YLR166C SEC10 het Verified 1.99076237811946 0.0232535086410769 no 42 0.0321404641396927 175 0.012 FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION SITE OF POLARIZED GROWTH Essential 100kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion exocytosis|establishment of cell polarity|Golgi to plasma membrane transport|vesicle fusion|vesicle docking involved in exocytosis molecular_function mating projection tip|exocyst
YDR427W YDR427W RPN9 het Verified 1.97851718839376 0.0239351957418348 no 43 0.0269582551468929 156 0.012 FT PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS Non-ATPase regulatory subunit of the 26S proteasome; has similarity to putative proteasomal subunits in other species; null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defects; protein abundance increases in response to DNA replication stress proteasome assembly|ubiquitin-dependent protein catabolic process structural molecule activity proteasome storage granule|proteasome regulatory particle, lid subcomplex
YBR055C YBR055C PRP6 het Verified 1.96662721553074 0.0246131017569629 no 44 0.0225215755899636 139 0.025 FT RNA PROCESSING NUCLEUS Splicing factor, component of the U4/U6-U5 snRNP complex mRNA splicing, via spliceosome molecular_function U4/U6 x U5 tri-snRNP complex
YOR370C YOR370C MRS6 het Verified 1.94132735880521 0.0261092915421375 no 45 0.0138279660791701 125 0.003 FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM|PROTEIN PRENYLATION Rab escort protein; forms a complex with the Ras-like small GTPase Ypt1p that is required for the prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p); sequence similarity to mammalian choroideraemia gene; relative distribution to the nucleus increases upon DNA replication stress protein targeting to membrane|protein geranylgeranylation|ER to Golgi vesicle-mediated transport|activation of Rab GTPase activity Rab geranylgeranyltransferase activity|Rab GTPase binding Rab-protein geranylgeranyltransferase complex|membrane|cytoplasm
YGR191W YGR191W HIP1 het Verified 1.93882706650331 0.0262611995788287 no 46 0.037020098384972 137 0.009 FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE High-affinity histidine permease, also involved in the transport of manganese ions manganese ion transport|histidine transport high affinity L-histidine transmembrane transporter activity integral to membrane|plasma membrane
YJL076W YJL076W NET1 het Verified 1.92936306880255 0.0268429025696194 no 47 0.0288801733604454 173 0.011 FT CELL CYCLE|CELL DIVISION|GENE SILENCING NUCLEUS Core subunit of the RENT complex; involved in nucleolar silencing and telophase exit; stimulates transcription by RNA polymerase I and regulates nucleolar structure; NET1 has a paralog, TOF2, that arose from the whole genome duplication regulation of exit from mitosis|nucleolus organization|chromatin silencing at rDNA rDNA binding nucleolus|RENT complex
YGL069C_d YGL069C YGL069C het Dubious 1.91795888676085 0.0275581122325507 no 48 0.0424388507789234 204 0.019 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 92% of ORF overlaps the uncharacterized ORF YGL068W; deletion in cyr1 mutant results in loss of stress resistance Unknown Unknown Unknown
YDL208W YDL208W NHP2 het Verified 1.8985633747859 0.0288109538873531 no 49 0.0164010863953863 101 0.002 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing cleavage involved in rRNA processing|rRNA pseudouridine synthesis|snRNA pseudouridine synthesis snoRNA binding box H/ACA snoRNP complex
YMR061W YMR061W RNA14 het Verified 1.89619242378788 0.0289673023182585 no 50 0.0377732187923226 186 0.003 FT RNA PROCESSING NUCLEUS|MITOCHONDRION Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; bridges interaction between Rna15p and Hrp1p in the CF I complex; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping mRNA cleavage|mRNA polyadenylation RNA binding|protein heterodimerization activity mRNA cleavage factor complex|mitochondrion|nucleus
YAL038W YAL038W CDC19 het Verified 1.89310193159803 0.0291721576795366 no 51 0.0351312167069709 233 0.038 FT KETONE METABOLISM|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Pyruvate kinase; functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration; regulated via allosteric activation by fructose bisphosphate; CDC19 has a paralog, PYK2, that arose from the whole genome duplication pyruvate metabolic process|glycolysis pyruvate kinase activity cytosol|plasma membrane
YHR083W YHR083W SAM35 het Verified 1.85463875318558 0.0318239151191654 no 52 0.0429610631174451 182 0.019 FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Essential component of the sorting and assembly machinery (SAM complex or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their insertion into the outer membrane mitochondrial outer membrane translocase complex assembly|protein import into mitochondrial outer membrane molecular_function mitochondrial outer membrane|mitochondrial sorting and assembly machinery complex|mitochondrion
YPR177C_d YPR177C YPR177C het Dubious 1.83608979431696 0.0331721887196069 no 53 0.030313529076944 100 0.009 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 5' end of the essential PRP4 gene encoding a component of the U4/U6-U5 snRNP complex Unknown Unknown Unknown
YJL010C YJL010C NOP9 het Verified 1.82704100488679 0.0338468021672218 no 54 0.0298873465402734 166 0.004 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Essential subunit of U3-containing 90S preribosome involved in production of 18S rRNA and assembly of small ribosomal subunit; also part of pre-40S ribosome and required for its export into cytoplasm; binds RNA and contains pumilio domain endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal small subunit export from nucleus RNA binding preribosome, small subunit precursor|nucleolus|nucleus|90S preribosome
YIL046W YIL046W MET30 het Verified 1.82329592127891 0.0341292918675095 no 55 0.0341051807121894 195 0.000 FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CELL CYCLE|AMINO ACID METABOLISM|PROTEOLYSIS NUCLEUS UBIQUITIN LIGASE COMPLEX F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus response to cadmium ion|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|regulation of DNA-dependent DNA replication initiation|M phase of mitotic cell cycle|response to arsenic-containing substance|G1/S transition of mitotic cell cycle|protein polyubiquitination|regulation of transcription involved in G1 phase of mitotic cell cycle|protein ubiquitination ubiquitin binding nuclear SCF ubiquitin ligase complex|SCF ubiquitin ligase complex|nucleus
YOR340C YOR340C RPA43 het Verified 1.82301034947644 0.0341509117049214 no 56 0.108666137353401 425 0.012 FF|FT NUCLEUS RNA polymerase I subunit A43 transcription of nuclear large rRNA transcript from RNA polymerase I promoter DNA-directed RNA polymerase activity DNA-directed RNA polymerase I complex
YBR038W YBR038W CHS2 het Verified 1.81054401005027 0.035105732953911 no 57 0.0502814332192707 199 0.005 FT CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM SITE OF POLARIZED GROWTH Chitin synthase II; catalyzes transfer of N-acetylglucosamine (GlcNAc) to chitin upon activation of zymogenic form; required for chitin synthesis in the primary septum during cytokinesis; localization regulated by Cdk1p during mitosis; phosphorylation by Dbf2p kinase regulates its dynamics and chitin synthesis during cytokinesis actomyosin contractile ring contraction|cytokinesis chitin synthase activity integral to membrane|cellular bud neck
YMR220W YMR220W ERG8 het Verified 1.8055151824126 0.0354970509462595 no 58 0.0329293075629096 181 0.006 FT LIPID METABOLISM|COFACTOR METABOLISM NUCLEUS Phosphomevalonate kinase, an essential cytosolic enzyme that acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate organic acid phosphorylation|ergosterol biosynthetic process|isopentenyl diphosphate biosynthetic process, mevalonate pathway|farnesyl diphosphate biosynthetic process, mevalonate pathway phosphomevalonate kinase activity nucleus|cytoplasm
YER168C YER168C CCA1 het Verified 1.79937397104045 0.035979772052996 no 59 0.0322495666389957 183 0.017 FT RNA PROCESSING NUCLEUS|MITOCHONDRION ATP (CTP):tRNA-specific tRNA nucleotidyltransferase; different forms targeted to the nucleus, cytosol, and mitochondrion are generated via the use of multiple transcriptional and translational start sites tRNA 3'-terminal CCA addition tRNA adenylyltransferase activity mitochondrion|nucleus|mitochondrial matrix|cytoplasm
YGR245C YGR245C SDA1 het Verified 1.78245921215442 0.0373371884833803 no 60 0.0504436214528535 173 0.007 FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RIBOSOME BIOGENESIS|CYTOSKELETON ORGANIZATION NUCLEUS Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis ribosomal large subunit biogenesis|ribosomal large subunit export from nucleus|traversing start control point of mitotic cell cycle|actin cytoskeleton organization molecular_function nucleus
YIR022W YIR022W SEC11 het Verified 1.77510053641639 0.0379406442224765 no 61 0.0351550325593945 184 0.004 FT PROTEIN LOCALIZATION|PROTEOLYSIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM 18kDa catalytic subunit of the Signal Peptidase Complex (SPC; Spc1p, Spc2p, Spc3p, and Sec11p) which cleaves the signal sequence of proteins targeted to the endoplasmic reticulum signal peptide processing|protein targeting to ER peptidase activity signal peptidase complex|endoplasmic reticulum
YBR193C YBR193C MED8 het Verified 1.77144332910129 0.038243504356375 no 62 0.0318812064665643 188 0.007 FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter TBP-class protein binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II transcription corepressor activity|structural molecule activity core mediator complex
YGL207W YGL207W SPT16 het Verified 1.76484153084428 0.0387952012865279 no 63 0.0565790683794257 234 0.007 FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; some mutations cause reduced nucleosome occupancy over highly transcribed regions of the yeast genome DNA replication-independent nucleosome organization|regulation of transcription by chromatin organization|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription initiation from RNA polymerase II promoter|nucleosome assembly|transcription elongation from RNA polymerase II promoter|DNA-dependent DNA replication chromatin binding|nucleosome binding|histone binding nuclear chromatin|FACT complex|replication fork protection complex|alpha DNA polymerase:primase complex|transcription elongation factor complex
YER172C YER172C BRR2 het Verified 1.75782200996347 0.0393888995547226 no 64 0.0187885047205013 107 0.012 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING NUCLEUS RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) ATP-dependent RNA helicase activity U4/U6 x U5 tri-snRNP complex|U5 snRNP
YHR148W YHR148W IMP3 het Verified 1.74619912800988 0.0403881781511908 no 65 0.0627897378717793 227 0.031 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA rRNA processing|ribosome biogenesis snoRNA binding small-subunit processome|Mpp10 complex|90S preribosome
YJR023C_d YJR023C YJR023C het Dubious 1.71544000833303 0.043132292751085 no 66 0.0309268964165693 183 0.012 Putative protein of unknown function; open reading frame overlaps LSM8/YJR022W encoding an essential snRNP protein required for RNA processing and splicing Unknown Unknown Unknown
YNL163C YNL163C RIA1 het Verified 1.70323548923485 0.044262003838744 no 67 0.0368069808216072 199 0.006 FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEOTIDE METABOLISM Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis; with Sdo1p, promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; required for quality control check of newly made large ribosomal subunits before they are released into the pool of translating ribosomes mature ribosome assembly GTPase activity cytoplasm
YLL011W YLL011W SOF1 het Verified 1.69732371776139 0.0448177377832017 no 68 0.0261660862402944 149 0.011 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Essential protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function small-subunit processome|nucleolus|90S preribosome
YBR070C YBR070C ALG14 het Verified 1.68647886758483 0.0458518010193924 no 69 0.0510311643212693 229 0.011 FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Component of UDP-GlcNAc transferase required for the second step of dolichyl-linked oligosaccharide synthesis; anchors the catalytic subunit Alg13p to the ER membrane; similar to bacterial and human glycosyltransferases dolichol-linked oligosaccharide biosynthetic process protein anchor|N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity UDP-N-acetylglucosamine transferase complex|integral to endoplasmic reticulum membrane|nuclear outer membrane-endoplasmic reticulum membrane network|intrinsic to endoplasmic reticulum membrane
YDR082W YDR082W STN1 het Verified 1.67596761858026 0.0468722677443923 no 70 0.0329680398380323 168 0.002 FT NUCLEUS|CHROMOSOME Telomere end-binding and capping protein, plays a key role with Pol12p in linking telomerase action with completion of lagging strand synthesis, and in a regulatory step required for telomere capping telomere capping|negative regulation of telomere maintenance via telomerase single-stranded telomeric DNA binding nuclear telomere cap complex
YPL128C YPL128C TBF1 het Verified 1.67377896895767 0.0470870235455299 no 71 0.0337410953087628 182 0.000 FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|GENE SILENCING NUCLEUS|CHROMOSOME Telobox-containing general regulatory factor; binds TTAGGG repeats within subtelomeric anti-silencing regions (STARs), blocking silent chromatin propagation; binds majority of snoRNA gene promoters, required for full snoRNA expression; caps DSB flanked by long T2AG3 repeats and blocks checkpoint activation telomere maintenance via telomere lengthening|negative regulation of chromatin silencing|snoRNA transcription from an RNA polymerase II promoter|negative regulation of telomere maintenance via telomerase RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|chromatin insulator sequence binding|telomeric DNA binding nuclear chromosome, telomeric region|nucleus
YKL024C YKL024C URA6 het Verified 1.67375702632785 0.0470891805989303 no 72 0.032385655706593 160 0.002 FT NUCLEOTIDE METABOLISM NUCLEUS Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP) 'de novo' pyrimidine nucleobase biosynthetic process|nucleobase-containing compound metabolic process uridylate kinase activity|adenylate kinase activity nucleus|cytoplasm
YBR004C YBR004C GPI18 het Verified 1.67189260277885 0.0472727508607591 no 73 0.0474868113357272 326 0.005 FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION Functional ortholog of human PIG-V, which is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis; the authentic, non-tagged protein was localized to mitochondria GPI anchor biosynthetic process mannosyltransferase activity|dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity integral to endoplasmic reticulum membrane|mitochondrion|mannosyltransferase complex|integral to membrane|endoplasmic reticulum
YPR055W YPR055W SEC8 het Verified 1.66657376609955 0.0477995944708964 no 74 0.0521229447444131 234 0.030 FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Essential 121 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in ER and Golgi inheritance in small buds; relocalizes away from bud neck upon DNA replication stress Golgi inheritance|endoplasmic reticulum inheritance|Golgi to plasma membrane transport|exocytosis|vesicle fusion|vesicle docking involved in exocytosis molecular_function incipient cellular bud site|cellular bud neck|mating projection tip|exocyst|cellular bud tip
YGL055W YGL055W OLE1 het Verified 1.63698778725593 0.0508165107025652 no 75 0.0654528174398475 348 0.003 FF|FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria unsaturated fatty acid biosynthetic process electron carrier activity|stearoyl-CoA 9-desaturase activity integral to endoplasmic reticulum membrane|integral to membrane
YPR142C_d YPR142C YPR142C het Dubious 1.6340146745022 0.0511278846813081 no 76 0.0360236739445158 189 0.047 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RRP15, which is required for ribosomal RNA processing Unknown Unknown Unknown
YIL026C YIL026C IRR1 het Verified 1.58707822229651 0.0562474647676249 no 77 0.0826925158664548 387 0.028 FF|FT CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Subunit of the cohesin complex, which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms, essential for viability spore germination|fungal-type cell wall organization|cytogamy|mitotic sister chromatid cohesion chromatin binding nucleus|nuclear mitotic cohesin complex
YHR068W YHR068W DYS1 het Verified 1.55866031976771 0.0595383990635059 no 78 0.0619284896551737 271 0.016 FT KETONE METABOLISM|AMINO ACID METABOLISM Deoxyhypusine synthase, catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels; tetrameric peptidyl-lysine modification to hypusine transferase activity, transferring alkyl or aryl (other than methyl) groups cytoplasm
YBL034C YBL034C STU1 het Verified 1.54229727851109 0.0615006849967078 no 79 0.0365332046685248 170 0.004 FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION NUCLEUS|CHROMOSOME|CYTOSKELETON Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles microtubule nucleation structural constituent of cytoskeleton spindle pole body
YDR302W YDR302W GPI11 het Verified 1.53818260559717 0.0620019863977125 no 80 0.0972422179962792 333 0.003 FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog GPI anchor biosynthetic process mannose-ethanolamine phosphotransferase activity integral to membrane|endoplasmic reticulum|endoplasmic reticulum membrane
YDR145W YDR145W TAF12 het Verified 1.53487018143575 0.0624078596747463 no 81 0.123403582862603 514 0.010 FF|FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS RNA POL II, HOLOENZYME|HISTONE ACETYLTRANSFERASE Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A histone acetylation|RNA polymerase II transcriptional preinitiation complex assembly|chromatin modification|transcription from RNA polymerase II promoter TBP-class protein binding|chromatin binding|RNA polymerase II activating transcription factor binding|protein complex scaffold|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly SLIK (SAGA-like) complex|SAGA complex|transcription factor TFIID complex
YGR073C_d YGR073C YGR073C het Dubious 1.52515422916817 0.0636103169173395 no 82 0.0793603740302662 322 0.012 Dubious open reading frame unlikely to encode a functional protein, extensively overlaps essential SMD1 gene encoding a U6 snRNP protein Unknown Unknown Unknown
YOR254C YOR254C SEC63 het Verified 1.51269227713801 0.0651789210952404 no 83 0.0594552957279756 299 0.005 FT PROTEIN LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER posttranslational protein targeting to membrane, translocation|cytosol to ER transport|SRP-dependent cotranslational protein targeting to membrane|posttranslational protein targeting to membrane protein transporter activity mitochondrion|integral to membrane|Sec62/Sec63 complex|endoplasmic reticulum membrane
YJR002W YJR002W MPP10 het Verified 1.50748759281247 0.0658428608648782 no 84 0.0477747442260338 200 0.003 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Component of the SSU processome and 90S preribosome, required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and Imp4p, essential for viability; similar to human Mpp10p endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function small-subunit processome|Mpp10 complex|nucleolus|nucleus|90S preribosome
YGL099W YGL099W LSG1 het Verified 1.50444938102389 0.0662328488013621 no 85 0.122260317901814 644 0.003 FF|FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS SITE OF POLARIZED GROWTH Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm conjugation with cellular fusion|ribosomal large subunit assembly|ribosomal subunit export from nucleus|ascospore formation GTPase activity mating projection tip|cytoplasm
YDR367W YDR367W KEI1 het Verified 1.5016424822803 0.0665947328477649 no 86 0.0904659925272406 368 0.007 FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene inositolphosphoceramide metabolic process inositol phosphoceramide synthase regulator activity integral to membrane|Golgi apparatus|integral to Golgi membrane|inositol phosphoceramide synthase complex|cytoplasm
YDR325W YDR325W YCG1 het Verified 1.49464917517359 0.0675030125594139 no 87 0.0686297652790837 279 0.016 FT CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation and chromatin binding of the condensin complex; required for clustering of tRNA genes at the nucleolus; required for replication slow zone (RSZ) breakage following Mec1p inactivation rDNA condensation|meiotic chromosome condensation|mitotic chromosome condensation|tRNA gene clustering|mitotic sister chromatid segregation molecular_function nuclear condensin complex
YGL238W YGL238W CSE1 het Verified 1.47815828143689 0.069682708701001 no 88 0.0863603740073624 347 0.005 FT PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION ENDOMEMBRANE SYSTEM|NUCLEUS Nuclear envelope protein that mediates the nuclear export of importin alpha (Srp1p), homolog of metazoan CAS protein, required for accurate chromosome segregation protein export from nucleus importin-alpha export receptor activity nuclear envelope|integral to membrane
YLR186W YLR186W EMG1 het Verified 1.47349505365916 0.0703087983069751 no 89 0.0826378628121495 250 0.002 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS|CYTOSKELETON Methyltransferase for rRNA; catalyzes methylation of the pseudouridine residue 1191 of 18S rRNA; member of the SPOUT methyltransferase family; required for maturation of 18S rRNA and for 40S ribosomal subunit production independently of methyltransferase activity; forms homodimers; human ortholog is mutated in Bowen-Conradi syndrome, and the equivalent mutation in yeast affects Emg1p dimerization and localization but not its methyltransferase activity endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal small subunit biogenesis|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA base methylation|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA processing rRNA (pseudouridine) methyltransferase activity small-subunit processome|nucleolus|nucleus|nuclear microtubule|cytoplasm|90S preribosome
YOR232W YOR232W MGE1 het Verified 1.47199394336359 0.0705112565601078 no 90 0.0955606101011146 379 0.010 FT PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial matrix cochaperone, acts as a nucleotide release factor for Ssc1p in protein translocation and folding; also acts as cochaperone for Ssq1p in folding of Fe-S cluster proteins; homolog of E. coli GrpE protein refolding|protein import into mitochondrial matrix adenyl-nucleotide exchange factor activity mitochondrion|presequence translocase-associated import motor|mitochondrial matrix
YBR110W YBR110W ALG1 het Verified 1.46232308456092 0.071826347767097 no 91 0.0592483060386928 280 0.020 FT LIPID METABOLISM|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Mannosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability, mutation is functionally complemented by human ortholog oligosaccharide-lipid intermediate biosynthetic process|protein N-linked glycosylation beta-1,4-mannosyltransferase activity integral to membrane|endoplasmic reticulum
YLR116W YLR116W MSL5 het Verified 1.44237500749959 0.0745983052245947 no 92 0.0934548268957052 345 0.006 FT RNA PROCESSING NUCLEUS Component of the commitment complex, which defines the first step in the splicing pathway; essential protein that interacts with Mud2p and Prp40p, forming a bridge between the intron ends; also involved in nuclear retention of pre-mRNA mRNA splicing, via spliceosome pre-mRNA branch point binding commitment complex
YGR009C YGR009C SEC9 het Verified 1.4359386496035 0.0755098997047198 no 93 0.0586396501235746 272 0.030 FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION PLASMA MEMBRANE t-SNARE protein important for fusion of secretory vesicles with the plasma membrane; similar to but not functionally redundant with Spo20p; SNAP-25 homolog Golgi to plasma membrane transport|vesicle fusion SNAP receptor activity SNARE complex|extrinsic to plasma membrane
YMR168C YMR168C CEP3 het Verified 1.40560046276265 0.0799213992814282 no 94 0.0619410909389968 307 0.002 FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CYTOSKELETON ORGANIZATION NUCLEUS|CHROMOSOME KINETOCHORE Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain septin ring assembly|mitotic cell cycle spindle assembly checkpoint sequence-specific DNA binding|DNA binding, bending|centromeric DNA binding condensed nuclear chromosome kinetochore|CBF3 complex
YDR355C_d YDR355C YDR355C het Dubious 1.4031644577399 0.0802839017740905 no 95 0.0492753971061984 207 0.006 Dubious: Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified essential ORF SPC110/YDR356W Unknown Unknown Unknown
YAL025C YAL025C MAK16 het Verified 1.39737673431956 0.0811501558349048 no 96 0.081567024200623 326 0.016 FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Essential nuclear protein, constituent of 66S pre-ribosomal particles; required for maturation of 25S and 5.8S rRNAs; required for maintenance of M1 satellite double-stranded RNA of the L-A virus maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal large subunit biogenesis|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function nucleolus|preribosome, large subunit precursor
YPR088C YPR088C SRP54 het Verified 1.38177849282392 0.0835198623525349 no 97 0.0769263061886806 276 0.013 FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition|SRP-dependent cotranslational protein targeting to membrane|protein targeting to ER 7S RNA binding|GTP binding|signal sequence binding signal recognition particle, endoplasmic reticulum targeting
YBL026W YBL026W LSM2 het Verified 1.36908859751291 0.0854857910710325 no 98 0.138108951089836 548 0.005 FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress nuclear-transcribed mRNA catabolic process|mRNA splicing, via spliceosome RNA binding U6 snRNP|nucleolus|small nucleolar ribonucleoprotein complex|cytoplasmic mRNA processing body|U4/U6 x U5 tri-snRNP complex
YDL087C YDL087C LUC7 het Verified 1.3645243455225 0.0862012986397494 no 99 0.0964100223930041 356 0.007 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING NUCLEUS Essential protein associated with the U1 snRNP complex; splicing factor involved in recognition of 5' splice site; contains two zinc finger motifs; N-terminal zinc finger binds pre-mRNA mRNA splice site selection mRNA binding U1 snRNP|U2-type prespliceosome
YPL082C YPL082C MOT1 het Verified 1.35789848809413 0.0872479486035515 no 100 0.0687972952486047 298 0.017 FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS|MITOCHONDRION|CHROMOSOME Essential protein involved in regulation of transcription; removes Spt15p (TBP) from DNA via its C-terminal ATPase activity, forms a complex with TBP that binds TATA DNA with high affinity but with altered specificity; the Mot1p-Spt15p-DNA ternary complex contains unbent DNA regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription of nuclear large rRNA transcript from RNA polymerase I promoter|regulation of transcription from RNA polymerase II promoter|rRNA processing TBP-class protein binding|ATPase activity nuclear chromosome|mitochondrion
YJL194W YJL194W CDC6 het Verified 1.34108387049108 0.0899466117564458 no 101 0.0937539976060376 354 0.002 FT CELL CYCLE|CELL DIVISION|GENE SILENCING NUCLEUS|PLASMA MEMBRANE Essential ATP-binding protein required for DNA replication; component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p; relocalizes from nucleus to cytoplasm upon DNA replication stress regulation of DNA-dependent DNA replication initiation|regulation of chromatin silencing at telomere|pre-replicative complex assembly|G1/S transition of mitotic cell cycle DNA replication origin binding|protein binding|chromatin binding|ATPase activity|GTP binding|GTPase activity|ATP binding DNA replication preinitiation complex|pre-replicative complex
YPR183W YPR183W DPM1 het Verified 1.33902901802608 0.0902806131953485 no 102 0.0921940417458941 364 0.002 FT LIPID METABOLISM|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION Dolichol phosphate mannose (Dol-P-Man) synthase of the ER membrane, catalyzes the formation of Dol-P-Man from Dol-P and GDP-Man; required for glycosyl phosphatidylinositol membrane anchoring, O mannosylation, and protein glycosylation GPI anchor biosynthetic process|protein O-linked glycosylation|protein N-linked glycosylation dolichyl-phosphate beta-D-mannosyltransferase activity mitochondrial outer membrane|mitochondrion|endoplasmic reticulum|nuclear outer membrane-endoplasmic reticulum membrane network
YNR016C YNR016C ACC1 het Verified 1.3368052110022 0.0906431138965698 no 103 0.150461089538357 585 0.005 FF|FT PROTEIN LOCALIZATION|KETONE METABOLISM|LIPID METABOLISM|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids; nuclear envelope organization|protein import into nucleus|fatty acid biosynthetic process biotin carboxylase activity|acetyl-CoA carboxylase activity mitochondrion|endoplasmic reticulum membrane
YBL097W YBL097W BRN1 het Verified 1.33164801603337 0.0914879394016996 no 104 0.0955080631454908 386 0.003 FT CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Subunit of the condensin complex; required for chromosome condensation and for clustering of tRNA genes at the nucleolus; may influence multiple aspects of chromosome transmission mitotic chromosome condensation|tRNA gene clustering|mitotic sister chromatid segregation molecular_function nucleus|SMC loading complex|nuclear condensin complex
YGR103W YGR103W NOP7 het Verified 1.32827677085399 0.0920433453536939 no 105 0.087358675330994 310 0.001 FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Component of several different pre-ribosomal particles; forms a complex with Ytm1p and Erb1p that is required for maturation of the large ribosomal subunit; required for exit from G0 and the initiation of cell proliferation ribosomal large subunit biogenesis|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|cell cycle molecular_function PeBoW complex|nucleolus|nucleus|preribosome, large subunit precursor
YAR008W YAR008W SEN34 het Verified 1.32737516902699 0.0921923047228525 no 106 0.0556486591454865 267 0.000 FT RNA PROCESSING ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease tRNA-type intron splice site recognition and cleavage tRNA-intron endonuclease activity mitochondrial outer membrane|mitochondrion|tRNA-intron endonuclease complex
YJR067C YJR067C YAE1 het Verified 1.32697560298001 0.0922583766064597 no 107 0.104703643663826 341 0.012 FT NUCLEUS Protein that forms a complex with Lto1p and Rli1p; essential for growth under standard (aerobic) conditions but not under anaerobic conditions; may have a role in protection of ribosomal assembly and function from damage due to reactive oxygen species biological_process molecular_function nucleus|cytoplasm
YOR048C YOR048C RAT1 het Verified 1.31470240248648 0.0943049694199565 no 108 0.105939777081281 426 0.005 FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS|MITOCHONDRION Nuclear 5' to 3' single-stranded RNA exonuclease, involved in RNA metabolism, including rRNA and snRNA processing as well as poly (A+) dependent and independent mRNA transcription termination termination of RNA polymerase II transcription, exosome-dependent|nuclear mRNA surveillance|termination of RNA polymerase II transcription, poly(A)-coupled|rRNA processing|RNA processing 5'-3' exoribonuclease activity mitochondrion|nucleus
YER104W YER104W RTT105 het Verified 1.30948388544906 0.0951852464144615 no 109 0.108693681102346 412 0.011 FT NUCLEUS Protein with a role in regulation of Ty1 transposition negative regulation of transposition, RNA-mediated molecular_function nucleus|cytoplasm
YHR197W YHR197W RIX1 het Verified 1.29886905029246 0.0969944363456965 no 110 0.11720691468178 440 0.001 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and possibly pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; RIX1 is an essential gene ribosomal large subunit assembly|ribosomal subunit export from nucleus|rRNA processing molecular_function nucleoplasm|nucleus
YDR180W YDR180W SCC2 het Verified 1.29831704698632 0.0970892054600459 no 111 0.0895614425433752 364 0.002 FT PROTEIN LOCALIZATION|CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during DSB repair via histone H2AX; evolutionarily-conserved adherin double-strand break repair|establishment of protein localization to chromatin|protein localization to chromatin|2-micrometer plasmid partitioning|mitotic chromosome condensation|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery|establishment of mitotic sister chromatid cohesion|rDNA condensation|tRNA gene clustering molecular_function nuclear chromatin|2-micrometer circle DNA|SMC loading complex
YBR155W YBR155W CNS1 het Verified 1.29623735114811 0.0974468624700811 no 112 0.0720420936946363 282 0.003 TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion protein folding Hsp70 protein binding|Hsp90 protein binding cytoplasm
YIL078W YIL078W THS1 het Verified 1.2930494670818 0.0979969754352223 no 113 0.0833436573128701 336 0.001 FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION MITOCHONDRION Threonyl-tRNA synthetase, essential cytoplasmic protein cytoplasmic translation|threonyl-tRNA aminoacylation threonine-tRNA ligase activity mitochondrion|cytoplasm
YOR294W YOR294W RRS1 het Verified 1.29167238308295 0.0982353126733449 no 114 0.103616242627182 432 0.016 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Essential protein that binds ribosomal protein L11; required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; localizes to the nucleolus and in foci along nuclear periphery; cooperates with Ebp2p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering; mouse homolog shows altered expression in Huntington's disease model mice endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal large subunit biogenesis|ribosomal large subunit export from nucleus molecular_function nucleoplasm|nuclear periphery|nucleolus|preribosome, large subunit precursor
YOR176W YOR176W HEM15 het Verified 1.27548577523143 0.101068677909121 no 115 0.111351423582288 355 0.002 FT COFACTOR METABOLISM MITOCHONDRION Ferrochelatase, a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway heme biosynthetic process ferrochelatase activity mitochondrion|mitochondrial inner membrane
YOR075W YOR075W UFE1 het Verified 1.27312709607858 0.10148647263512 no 116 0.107179256491805 421 0.014 FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM t-SNARE required for retrograde vesicular traffic and homotypic ER membrane fusion; forms a complex with the SNAREs Sec22p, Sec20p and Use1p to mediate fusion of Golgi-derived vesicles at the ER retrograde vesicle-mediated transport, Golgi to ER|endoplasmic reticulum membrane fusion|vesicle fusion with endoplasmic reticulum SNAP receptor activity SNARE complex|integral to membrane|endoplasmic reticulum
YKR037C YKR037C SPC34 het Verified 1.25865307479533 0.10407783378572 no 117 0.101380357809486 383 0.003 FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME|CYTOSKELETON KINETOCHORE Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body microtubule nucleation|mitotic spindle organization in nucleus|regulation of microtubule polymerization or depolymerization microtubule binding|structural constituent of cytoskeleton spindle microtubule|DASH complex|condensed nuclear chromosome kinetochore|spindle pole body|spindle
YLR317W_d YLR317W YLR317W het Dubious 1.25518905329473 0.104705069213225 no 118 0.0811970872965596 333 0.029 Dubious open reading frame; may be part of a bicistronic transcript with NKP2/YLR315W; overlaps the verified ORF TAD3/YLR316C Unknown Unknown Unknown
YDL003W YDL003W MCD1 het Verified 1.22624142101608 0.110053919091765 no 119 0.118054473662713 433 0.004 FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION|CHROMOSOME SEGREGATION NUCLEUS|MITOCHONDRION|CHROMOSOME Essential alpha-kleisin subunit of the cohesin complex; required for sister chromatid cohesion in mitosis and meiosis; apoptosis induces cleavage and translocation of a C-terminal fragment to mitochondria; expression peaks in S phase double-strand break repair|apoptotic process|response to DNA damage stimulus|mitotic chromosome condensation|establishment of mitotic sister chromatid cohesion chromatin binding condensed nuclear chromosome|mitochondrion|nucleus|nuclear mitotic cohesin complex
YDL016C_d YDL016C YDL016C het Dubious 1.2223929893437 0.11077952457218 no 120 0.116727837256364 426 0.006 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CDC7/YDL153C, the catalytic subunit of a complex that regulates DNA replication Unknown Unknown Unknown
YNL256W YNL256W FOL1 het Verified 1.21668368524966 0.111862294376624 no 121 0.0828350546468704 315 0.006 FT KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM MITOCHONDRION Multifunctional enzyme of the folic acid biosynthesis pathway, has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities tetrahydrofolate biosynthetic process dihydroneopterin aldolase activity|2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity|dihydropteroate synthase activity mitochondrial envelope|mitochondrion|cytoplasm
YDR478W YDR478W SNM1 het Verified 1.2110105750591 0.112945675884839 no 122 0.128721291357532 438 0.031 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP mRNA cleavage|rRNA processing ribonuclease MRP activity|RNA binding ribonuclease MRP complex
YOR373W YOR373W NUD1 het Verified 1.17988730828535 0.119022519171138 no 123 0.125284437668666 375 0.006 FT CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON Component of the spindle pole body outer plaque; acts through the mitotic exit network to specify asymmetric spindle pole body inheritance meiotic chromosome segregation|spindle pole body separation|exit from mitosis|establishment of spindle localization structural constituent of cytoskeleton spindle pole body
YDL043C YDL043C PRP11 het Verified 1.17399806585415 0.120197900169575 no 124 0.124826998152485 400 0.007 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING NUCLEUS Subunit of the SF3a splicing factor complex, required for spliceosome assembly spliceosomal complex assembly RNA binding U2 snRNP|U2-type prespliceosome
YNL222W YNL222W SSU72 het Verified 1.16712435993189 0.121580075819188 no 125 0.0790481779534945 329 0.002 FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Phosphatase and transcription/RNA-processing factor; associates with TFIIB and cleavage/polyadenylation factor Pta1p; exhibits phosphatase activity on serine-5 and serine-7 of the RNA polymerase II C-terminal domain; affects start site selection and transcriptional read through in vivo transcription initiation from RNA polymerase II promoter|mRNA 3'-end processing|mRNA cleavage|termination of RNA polymerase II transcription|termination of RNA polymerase II transcription, poly(A)-coupled|transcription antitermination|transcriptional start site selection at RNA polymerase II promoter|dephosphorylation of RNA polymerase II C-terminal domain|termination of RNA polymerase II transcription, exosome-dependent|snoRNA transcription|transcription elongation from RNA polymerase II promoter protein tyrosine phosphatase activity|phosphoprotein phosphatase activity|CTD phosphatase activity mRNA cleavage and polyadenylation specificity factor complex|nucleus
YGR190C_d YGR190C YGR190C het Dubious 1.16551713810963 0.121904863556175 no 126 0.111233705217601 435 0.000 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W Unknown Unknown Unknown
YPL233W YPL233W NSL1 het Verified 1.16544523354798 0.121919408275238 no 127 0.125815935368968 413 0.004 FT CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME|CYTOSKELETON KINETOCHORE Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation chromosome segregation molecular_function nuclear MIS12/MIND type complex|kinetochore|spindle pole
YDR053W_d YDR053W YDR053W het Dubious 1.16102982820443 0.122814884701413 no 128 0.126156960859685 473 0.000 Putative protein of unknown function; open reading frame overlaps 5' end of essential DBF4 gene encoding the regulatory subunit of the Cdc7p-Dbf4p kinase complex Unknown Unknown Unknown
YOL040C YOL040C RPS15 het Verified 1.16093478921188 0.122834209878569 no 129 0.184206065712729 644 0.003 FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19 cytoplasmic translation|rRNA export from nucleus structural constituent of ribosome cytosolic small ribosomal subunit
YBR089W_d YBR089W YBR089W het Dubious 1.15749412309064 0.12353526949637 no 130 0.0966924684665083 360 0.001 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene POL30 Unknown Unknown Unknown
YIL150C YIL150C MCM10 het Verified 1.15689257935937 0.123658125440408 no 131 0.146183455538486 495 0.009 FT CELL CYCLE|RESPONSE TO DNA DAMAGE|GENE SILENCING NUCLEUS|CHROMOSOME Essential chromatin-associated protein involved in the initiation of DNA replication; required for the association of the MCM2-7 complex with replication origins S phase of mitotic cell cycle|DNA strand elongation involved in DNA replication|double-strand break repair via break-induced replication|DNA replication initiation|chromatin silencing at telomere|chromatin silencing at silent mating-type cassette double-stranded DNA binding|protein binding|DNA replication origin binding|single-stranded DNA binding replication fork protection complex|replication fork|nucleus
YOR119C YOR119C RIO1 het Verified 1.14740829717881 0.125606456811168 no 132 0.132700773588293 449 0.014 FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|CELL DIVISION|PROTEIN PHOSPHORYLATION NUCLEUS Essential serine kinase involved in cell cycle progression and processing of the 20S pre-rRNA into mature 18S rRNA regulation of exit from mitosis|S phase of mitotic cell cycle|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) protein kinase activity nucleus|cytoplasm
YDR168W YDR168W CDC37 het Verified 1.13367410804934 0.128465637166491 no 133 0.133430506087223 469 0.018 FT CELL CYCLE|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION Essential Hsp90p co-chaperone; necessary for passage through the START phase of the cell cycle; stabilizes protein kinase nascent chains and participates along with Hsp90p in their folding regulation of stress-activated MAPK cascade|regulation of cell cycle|MAPK cascade involved in osmosensory signaling pathway|protein stabilization|spindle pole body duplication associated with nuclear envelope unfolded protein binding cytoplasm
YDR324C YDR324C UTP4 het Verified 1.11569300705177 0.132276782455945 no 134 0.174148375660321 593 0.004 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcript positive regulation of transcription from RNA polymerase I promoter|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function small-subunit processome|nucleolus|t-UTP complex|90S preribosome
YLR379W_d YLR379W YLR379W het Dubious 1.11173840989598 0.13312531997504 no 135 0.142551873187451 466 0.003 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential ORF SEC61/YLR378C Unknown Unknown Unknown
YNL150W_d YNL150W YNL150W het Dubious 1.10828038968868 0.133870370964674 no 136 0.163396870446713 561 0.024 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; extensive overlap with PGA2/YNL149C, an uncharacterized gene with a proposed role in protein trafficking Unknown Unknown Unknown
YPL153C YPL153C RAD53 het Verified 1.08462316578195 0.139044295250677 no 137 0.129269422952264 458 0.022 FT PROTEIN LOCALIZATION|CELL CYCLE|RESPONSE TO DNA DAMAGE|NUCLEOTIDE METABOLISM|PROTEIN PHOSPHORYLATION NUCLEUS Protein kinase, required for cell-cycle arrest in response to DNA damage; activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p; also interacts with ARS1 and plays a role in initiation of DNA replication DNA repair|protein localization|protein phosphorylation|nucleobase-containing compound metabolic process|DNA damage checkpoint|DNA replication initiation|deoxyribonucleoside triphosphate biosynthetic process protein serine/threonine/tyrosine kinase activity|DNA replication origin binding|protein kinase activity nucleus
YPR085C YPR085C ASA1 het Verified 1.06278663034907 0.143939361957194 no 138 0.180555092465821 600 0.001 FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1 biological_process molecular_function ASTRA complex
YLL018C YLL018C DPS1 het Verified 1.06128692573436 0.144279762797064 no 139 0.185505575629587 629 0.000 FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION NUCLEUS Aspartyl-tRNA synthetase, primarily cytoplasmic; homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulation cytoplasmic translation|aspartyl-tRNA aminoacylation RNA binding|aspartate-tRNA ligase activity nucleus|cytoplasm
YOL130W YOL130W ALR1 het Verified 1.06114260557428 0.14431254898224 no 140 0.152055011126154 520 0.001 FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions magnesium ion transport|cation transport inorganic cation transmembrane transporter activity integral to membrane|plasma membrane
YMR076C YMR076C PDS5 het Verified 1.06062589895727 0.144429973885884 no 141 0.152820936837852 526 0.001 FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Protein required for establishment and maintenance of sister chromatid condensation and cohesion, colocalizes with cohesin on chromosomes, may function as a protein-protein interaction scaffold; also required during meiosis double-strand break repair|meiosis|synapsis|mitotic chromosome condensation|mitotic sister chromatid cohesion structural molecule activity condensed nuclear chromosome
YDL064W YDL064W UBC9 het Verified 1.05993740512025 0.144586538570565 no 142 0.12201767214693 446 0.001 FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION NUCLEUS|CHROMOSOME SUMO-conjugating enzyme involved in the Smt3p conjugation pathway; nuclear protein required for S- and M-phase cyclin degradation and mitotic control; involved in proteolysis mediated by the anaphase-promoting complex cyclosome (APCC) G2/M transition of mitotic cell cycle|protein sumoylation|mitotic spindle elongation SUMO ligase activity condensed nuclear chromosome|nucleus
YDL209C YDL209C CWC2 het Verified 1.0591699994882 0.144761182631072 no 143 0.174266784598484 587 0.001 FT CELL CYCLE|RNA PROCESSING NUCLEUS Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; binds directly to U6 snRNA; similar to S. pombe Cwf2 mRNA cis splicing, via spliceosome|mRNA splicing, via spliceosome|spliceosomal snRNP assembly pre-mRNA binding|first spliceosomal transesterification activity|U6 snRNA binding|second spliceosomal transesterification activity Prp19 complex|U2-type catalytic step 1 spliceosome|U2-type catalytic step 2 spliceosome
YJR042W YJR042W NUP85 het Verified 1.05837130963736 0.144943097080643 no 144 0.17390410247549 610 0.010 FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RIBOSOME BIOGENESIS|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP85 aka NUP75 positive regulation of transcription, DNA-dependent|mRNA export from nucleus|ribosomal large subunit export from nucleus|protein import into nucleus|nuclear pore distribution structural constituent of nuclear pore integral to membrane|nuclear pore|nuclear pore outer ring
YPL028W YPL028W ERG10 het Verified 1.04874237106019 0.147148353700553 no 145 0.124438378323973 472 0.003 FT LIPID METABOLISM Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis ergosterol biosynthetic process acetyl-CoA C-acetyltransferase activity cytosol
YLR359W YLR359W ADE13 het Verified 1.0455162248087 0.147892222904504 no 146 0.139704626198355 518 0.002 FT NUCLEOTIDE METABOLISM Adenylosuccinate lyase, catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human ortholog ADSL cause adenylosuccinase deficiency purine nucleotide biosynthetic process|'de novo' IMP biosynthetic process N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity cellular_component
YBL084C YBL084C CDC27 het Verified 1.04342103211142 0.148376668402246 no 147 0.172684922887853 562 0.001 FT CELL CYCLE|CELL DIVISION|PROTEOLYSIS NUCLEUS UBIQUITIN LIGASE COMPLEX Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination ubiquitin-protein ligase activity anaphase-promoting complex
YDR021W YDR021W FAL1 het Verified 1.04242178251358 0.148608085924494 no 148 0.113003409107831 385 0.001 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Nucleolar protein required for maturation of 18S rRNA, member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ATP-dependent RNA helicase activity nucleolus|FAl1-SGD1 complex
YML025C YML025C YML6 het Verified 1.0409732221767 0.148943988143288 no 149 0.15229380637429 477 0.003 FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YNL110C YNL110C NOP15 het Verified 1.03825009640493 0.149576817603676 no 150 0.203794634985415 716 0.002 FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|CELL DIVISION|CYTOSKELETON ORGANIZATION NUCLEUS Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm cytokinesis, actomyosin contractile ring assembly|ribosomal large subunit biogenesis molecular_function nucleolus|nucleus|preribosome, large subunit precursor
YGL201C YGL201C MCM6 het Verified 1.0367231300252 0.14993245459584 no 151 0.154716598005033 535 0.008 FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex; forms a subcomplex with Mcm4p and Mcm7p S phase of mitotic cell cycle|DNA strand elongation involved in DNA replication|DNA unwinding involved in replication|double-strand break repair via break-induced replication|pre-replicative complex assembly|DNA replication initiation four-way junction helicase activity|DNA helicase activity|DNA replication origin binding|single-stranded DNA-dependent ATPase activity|ATP-dependent 3'-5' DNA helicase activity replication fork protection complex|DNA replication preinitiation complex|nucleus|pre-replicative complex|cytoplasm|MCM complex
YNL178W YNL178W RPS3 het Verified 1.02847159034644 0.151864023953713 no 152 0.202187513195209 694 0.000 FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION RIBOSOME Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; homologous to mammalian ribosomal protein S3 and bacterial S3 cytoplasmic translation|rRNA export from nucleus structural constituent of ribosome|DNA-(apurinic or apyrimidinic site) lyase activity preribosome, small subunit precursor|cytosolic small ribosomal subunit|90S preribosome
YCL054W YCL054W SPB1 het Verified 1.02798385951504 0.151978710075251 no 153 0.168602086459597 620 0.006 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA methylation rRNA (uridine-2'-O-)-methyltransferase activity|rRNA (guanine) methyltransferase activity nucleolus|nucleus|preribosome, large subunit precursor
YGL233W YGL233W SEC15 het Verified 1.02194404128948 0.153403693112843 no 154 0.11816752518066 458 0.003 FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Essential 113 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; interacts with and functions as a downstream effector of active, GTP-bound Sec4p, a Rab family GTPase Golgi to plasma membrane transport|exocytosis|vesicle fusion|vesicle docking involved in exocytosis Rab GTPase binding incipient cellular bud site|cellular bud neck|mating projection tip|cellular bud tip|exocyst
YKL045W YKL045W PRI2 het Verified 1.01863274307145 0.15418867676028 no 155 0.156593157028084 522 0.007 FT RESPONSE TO DNA DAMAGE ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair lagging strand elongation|DNA replication, synthesis of RNA primer|DNA synthesis involved in DNA repair|DNA replication|DNA replication initiation single-stranded DNA binding|DNA primase activity nuclear envelope|alpha DNA polymerase:primase complex|nucleus
YGR145W YGR145W ENP2 het Verified 1.01198290240124 0.155773114222955 no 156 0.167235601961039 567 0.002 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Essential nucleolar protein, required for biogenesis of the small ribosomal subunit; contains WD repeats, interacts with Mpp10p and Bfr2p, and has homology to Spb1p ribosomal small subunit biogenesis|rRNA processing molecular_function nucleolus|90S preribosome
YBR237W YBR237W PRP5 het Verified 1.01030082280492 0.156175593535493 no 157 0.134918911839313 494 0.000 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING NUCLEUS RNA helicase in the DEAD-box family, necessary for prespliceosome formation, bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA mRNA branch site recognition RNA-dependent ATPase activity spliceosomal complex
YBR011C YBR011C IPP1 het Verified 1.01026389135775 0.156184437981228 no 158 0.174541396876765 593 0.010 Cytoplasmic inorganic pyrophosphatase (PPase), homodimer that catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase phosphate-containing compound metabolic process inorganic diphosphatase activity|protein homodimerization activity cytosol
YFL037W YFL037W TUB2 het Verified 0.999833492825337 0.158695547147423 no 159 0.152558964715686 530 0.000 FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|NUCLEOTIDE METABOLISM|CHROMOSOME SEGREGATION NUCLEUS|CYTOSKELETON Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria nuclear migration along microtubule|nuclear migration involved in conjugation with cellular fusion|homologous chromosome segregation|mitotic sister chromatid segregation structural constituent of cytoskeleton tubulin complex|kinetochore microtubule|cytoplasmic microtubule|nuclear microtubule|spindle pole body|polar microtubule
YPL020C YPL020C ULP1 het Verified 0.999437213835205 0.158791470026984 no 160 0.193994838528365 622 0.003 FT CELL CYCLE|PROTEOLYSIS ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE Protease that specifically cleaves Smt3p protein conjugates; required for cell cycle progression; associates with nucleoporins and may interact with septin rings during telophase; sequestered to the nucleolus under stress conditions G2/M transition of mitotic cell cycle|protein desumoylation cysteine-type peptidase activity|SUMO-specific protease activity nuclear envelope|nucleolus|nuclear pore
YMR211W YMR211W DML1 het Verified 0.996523682116365 0.159497883167688 no 161 0.21241587605463 740 0.001 FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family plasmid maintenance|mitochondrial genome maintenance molecular_function mitochondrion|cytoplasm
YER013W YER013W PRP22 het Verified 0.995758907299162 0.159683650346158 no 162 0.127249810777224 475 0.002 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING NUCLEUS DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes spliceosomal complex disassembly|generation of catalytic spliceosome for second transesterification step second spliceosomal transesterification activity|ATP-dependent RNA helicase activity U2-type post-spliceosomal complex|U2-type catalytic step 2 spliceosome
YKR083C YKR083C DAD2 het Verified 0.993567490901373 0.160216738816262 no 163 0.189359431081316 646 0.003 FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME|CYTOSKELETON KINETOCHORE Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis mitotic spindle organization in nucleus|regulation of microtubule polymerization or depolymerization microtubule binding|structural constituent of cytoskeleton DASH complex|condensed nuclear chromosome kinetochore|mitotic spindle
YFR002W YFR002W NIC96 het Verified 0.990679317174284 0.160921096774214 no 164 0.231792548958264 805 0.012 FF|FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup57p, and Nup49p) ribosomal large subunit export from nucleus|protein import into nucleus|nuclear pore organization structural constituent of nuclear pore integral to membrane|nuclear pore nuclear basket|nuclear pore linkers|nuclear pore
YNL062C YNL062C GCD10 het Verified 0.978771819669576 0.163846368310404 no 165 0.202233563778913 696 0.002 FT RNA PROCESSING|TRANSLATION NUCLEUS Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression tRNA methylation tRNA (adenine-N1-)-methyltransferase activity tRNA (m1A) methyltransferase complex|nucleus
YKR081C YKR081C RPF2 het Verified 0.977264573708138 0.164219093378158 no 166 0.193695640913675 646 0.004 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Essential protein involved in the processing of pre-rRNA and the assembly of the 60S ribosomal subunit; interacts with ribosomal protein L11; localizes predominantly to the nucleolus; constituent of 66S pre-ribosomal particles ribosomal large subunit assembly|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 7S RNA binding|5S rRNA binding|rRNA binding nucleolus|preribosome, large subunit precursor
YDL031W YDL031W DBP10 het Verified 0.973127068857867 0.165245076093435 no 167 0.157069320543483 530 0.004 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Putative ATP-dependent RNA helicase of the DEAD-box protein family, constituent of 66S pre-ribosomal particles; essential protein involved in ribosome biogenesis maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ATP-dependent RNA helicase activity nucleolus|preribosome, large subunit precursor
YMR049C YMR049C ERB1 het Verified 0.969268511886606 0.166205617805277 no 168 0.184323481618958 622 0.002 FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Ytm1p that is required for maturation of the large ribosomal subunit; required for maturation of the 25S and 5.8S ribosomal RNAs; homologous to mammalian Bop1 ribosomal large subunit biogenesis|rRNA processing molecular_function PeBoW complex|nucleolus|nucleus|preribosome, large subunit precursor
YGR002C YGR002C SWC4 het Verified 0.967734417669754 0.166588512237072 no 169 0.159232750936055 564 0.001 FT CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME HISTONE ACETYLTRANSFERASE Component of the Swr1p complex that incorporates Htz1p into chromatin; component of the NuA4 histone acetyltransferase complex DNA repair|histone acetylation|chromosome organization|chromatin modification|chromatin remodeling|histone exchange|establishment of mitotic sister chromatid cohesion DNA binding Swr1 complex|histone acetyltransferase complex|nucleus|NuA4 histone acetyltransferase complex
YDR468C YDR468C TLG1 het Verified 0.966933054832663 0.166788750507797 no 170 0.15935260292537 576 0.005 FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION GOLGI APPARATUS Essential t-SNARE that forms a complex with Tlg2p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds the docking complex VFT (Vps fifty-three) through interaction with Vps51p endocytosis|vesicle fusion SNAP receptor activity trans-Golgi network|SNARE complex|endosome
YOR250C YOR250C CLP1 het Verified 0.962009307717521 0.168022464241222 no 171 0.204263910275519 689 0.002 FT RNA PROCESSING NUCLEUS Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation mRNA 3'-end processing|mRNA cleavage|mRNA polyadenylation RNA binding mRNA cleavage factor complex
YDL139C YDL139C SCM3 het Verified 0.959890361454233 0.168555198838403 no 172 0.157239043373265 576 0.010 FT PROTEIN LOCALIZATION|CELL CYCLE|PROTEOLYSIS|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Nonhistone component of centromeric chromatin; binds stoichiometrically to CenH3-H4 histones, required for kinetochore assembly; required for G2/M progression and localization of Cse4p; may protect Cse4p from ubiquitylation; homolog of mammalian HJURP G2/M transition of mitotic cell cycle|chromosome segregation|protein localization to chromosome, centromeric region|Unknown centromere-specific nucleosome binding nucleus|condensed nuclear chromosome, centromeric region|cytoplasm
YLL004W YLL004W ORC3 het Verified 0.949467494019805 0.171191448494534 no 173 0.15994038533977 568 0.001 FT GENE SILENCING NUCLEUS|CHROMOSOME Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing pre-replicative complex assembly|DNA replication initiation|chromatin silencing at silent mating-type cassette chromatin binding|DNA replication origin binding DNA replication preinitiation complex|pre-replicative complex|nuclear origin of replication recognition complex
YGR114C_d YGR114C YGR114C het Dubious 0.948893386976911 0.171337419144801 no 174 0.271265979567827 914 0.001 FF Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps 5' end of the essential gene SPT6 Unknown Unknown Unknown
YLR051C YLR051C FCF2 het Verified 0.947423459772202 0.171711520744599 no 175 0.203056465076188 671 0.004 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Essential nucleolar protein involved in the early steps of 35S rRNA processing; interacts with Faf1p; member of a transcriptionally co-regulated set of genes called the RRB regulon endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function nucleolus|nucleus
YKL021C YKL021C MAK11 het Verified 0.943298332806515 0.172764164201297 no 176 0.163275830621648 574 0.004 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS ENDOMEMBRANE SYSTEM|NUCLEUS Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats ribosomal large subunit assembly|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal large subunit biogenesis|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function membrane
YDL205C YDL205C HEM3 het Verified 0.93944039276444 0.173752341278634 no 177 0.167562775976417 587 0.000 FT COFACTOR METABOLISM NUCLEUS Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme heme biosynthetic process hydroxymethylbilane synthase activity nucleus|cytoplasm
YOR174W YOR174W MED4 het Verified 0.938995452757319 0.173866539505465 no 178 0.215393501851409 748 0.002 FF|FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation transcription from RNA polymerase II promoter molecular_function core mediator complex
YKL019W YKL019W RAM2 het Verified 0.937026985491476 0.174372338529688 no 179 0.140152495087755 484 0.003 FT PROTEIN PRENYLATION Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor protein farnesylation|protein geranylgeranylation|peptide pheromone maturation protein geranylgeranyltransferase activity|protein farnesyltransferase activity|CAAX-protein geranylgeranyltransferase activity CAAX-protein geranylgeranyltransferase complex|protein farnesyltransferase complex
YBR143C YBR143C SUP45 het Verified 0.934323481230502 0.175068527715873 no 180 0.184004144486688 643 0.002 FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|CELL DIVISION Polypeptide release factor (eRF1) in translation termination; mutant form acts as a recessive omnipotent suppressor; methylated by Mtq2p-Trm112p in ternary complex eRF1-eRF3-GTP; mutation of methylation site confers resistance to zymocin; has a role in cytokinesis through interaction with Mlc1p translational termination|cytokinesis translation release factor activity, codon specific|translation release factor activity cytosol|translation release factor complex
YER021W YER021W RPN3 het Verified 0.93212701639842 0.175635443753362 no 181 0.201514558692211 706 0.010 FT PROTEOLYSIS Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control ubiquitin-dependent protein catabolic process molecular_function proteasome regulatory particle, lid subcomplex
YER094C YER094C PUP3 het Verified 0.921674943611639 0.178349077014676 no 182 0.236815928472121 772 0.000 FT PROTEOLYSIS ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10 proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process endopeptidase activator activity proteasome storage granule|nucleus|endoplasmic reticulum membrane|proteasome core complex, beta-subunit complex
YMR047C YMR047C NUP116 het Verified 0.921574793891404 0.178375205641751 no 183 0.15413583750718 545 0.001 FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup159p) poly(A)+ mRNA export from nucleus|mRNA export from nucleus|ribosomal large subunit export from nucleus|protein import into nucleus|nuclear pore organization|tRNA export from nucleus nucleocytoplasmic transporter activity|structural constituent of nuclear pore nuclear pore central transport channel|integral to membrane|nuclear pore cytoplasmic filaments|nuclear pore
YBR029C YBR029C CDS1 het Verified 0.920522917859274 0.178649781207609 no 184 0.234413611989964 732 0.003 FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase); an enzyme that catalyzes that conversion of CTP + phosphate into diphosphate + CDP-diaclglyerol, a critical step in the synthesis of all major yeast phospholipids phosphatidylserine metabolic process|phosphatidylglycerol biosynthetic process phosphatidate cytidylyltransferase activity mitochondrion|integral to membrane|endoplasmic reticulum
YDR390C YDR390C UBA2 het Verified 0.917172110190664 0.179526229498646 no 185 0.171992067734741 571 0.001 FT NUCLEUS Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Aos1p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability protein sumoylation SUMO activating enzyme activity SUMO activating enzyme complex|nucleus
YDL217C YDL217C TIM22 het Verified 0.916392626090162 0.179730500755027 no 186 0.169288320547178 632 0.003 FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Essential core component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; forms the channel through which proteins are imported protein import into mitochondrial inner membrane mitochondrion targeting sequence binding|protein channel activity mitochondrion|integral to membrane|mitochondrial inner membrane protein insertion complex
YBL014C YBL014C RRN6 het Verified 0.912897374126949 0.180648259352243 no 187 0.175202433515166 642 0.004 FT NUCLEUS Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p transcription initiation from RNA polymerase I promoter|transcription of nuclear large rRNA transcript from RNA polymerase I promoter RNA polymerase I regulatory region DNA binding|RNA polymerase I transcription factor binding|RNA polymerase I CORE element sequence-specific DNA binding transcription factor recruiting transcription factor activity RNA polymerase I core factor complex
YNL207W YNL207W RIO2 het Verified 0.909058489657482 0.181659626257881 no 188 0.198558423355537 684 0.003 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|PROTEIN PHOSPHORYLATION NUCLEUS Essential serine kinase involved in the processing of the 20S pre-rRNA into mature 18S rRNA; has similarity to Rio1p maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) nucleocytoplasmic transporter activity|protein kinase activity cytosol|nucleus|cytoplasm
YLR010C YLR010C TEN1 het Verified 0.906508885584347 0.182333281970355 no 189 0.196929314260249 657 0.002 FT NUCLEUS|CHROMOSOME Protein that regulates telomeric length; protects telomeric ends in a complex with Cdc13p and Stn1p negative regulation of telomere maintenance|telomere capping|telomere maintenance via telomerase single-stranded telomeric DNA binding nuclear telomere cap complex
YAL001C YAL001C TFC3 het Verified 0.904456395954086 0.182876722792579 no 190 0.222483210269655 797 0.002 FF|FT PROTEIN LOCALIZATION NUCLEUS|MITOCHONDRION|CHROMOSOME Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding protein localization to chromatin|transcription from a RNA polymerase III hybrid type promoter|transcription from RNA polymerase III type 2 promoter|5S class rRNA transcription from RNA polymerase III type 1 promoter RNA polymerase III type 1 promoter sequence-specific DNA binding|RNA polymerase III type 2 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity|RNA polymerase III type 2 promoter sequence-specific DNA binding|RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity|DNA binding, bending transcription factor TFIIIC complex|mitochondrion|nuclear condensin complex
YFL022C YFL022C FRS2 het Verified 0.902757576924528 0.183327285495213 no 191 0.191292984868213 652 0.001 FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar phenylalanyl-tRNA aminoacylation phenylalanine-tRNA ligase activity phenylalanine-tRNA ligase complex|cytoplasm
YLR274W YLR274W MCM5 het Verified 0.902169631782452 0.183483382061951 no 192 0.210357961959607 714 0.002 FT CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING NUCLEUS|CHROMOSOME Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase S phase of mitotic cell cycle|establishment of chromatin silencing|DNA replication initiation|regulation of DNA-dependent DNA replication initiation|negative regulation of chromatin silencing at telomere|pre-replicative complex assembly|double-strand break repair via break-induced replication|chromatin silencing at telomere DNA helicase activity|chromatin binding|DNA replication origin binding|single-stranded DNA binding replication fork protection complex|nuclear chromosome, telomeric region|DNA replication preinitiation complex|nucleus|pre-replicative complex|cytoplasm|MCM complex
YGL225W YGL225W VRG4 het Verified 0.900205062767047 0.184005566204304 no 193 0.21286588396034 739 0.000 FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi GDP-mannose transport GDP-mannose transmembrane transporter activity mitochondrion|integral to membrane|Golgi apparatus
YDL098C YDL098C SNU23 het Verified 0.899935982835049 0.184077159860803 no 194 0.183299977685653 615 0.001 FT RNA PROCESSING NUCLEUS Component of U4/U6.U5 snRNP involved in mRNA splicing via spliceosome mRNA splicing, via spliceosome molecular_function U4/U6 x U5 tri-snRNP complex
YBR152W YBR152W SPP381 het Verified 0.899074385585251 0.184306520270204 no 195 0.200386553303698 715 0.002 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING NUCLEUS mRNA splicing factor, component of U4/U6.U5 tri-snRNP; interacts genetically and physically with Prp38p mRNA splicing, via spliceosome|generation of catalytic spliceosome for first transesterification step molecular_function U4/U6 x U5 tri-snRNP complex
YMR033W YMR033W ARP9 het Verified 0.897071051564443 0.184840502314001 no 196 0.268129611454145 913 0.002 FF|FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS RSC COMPLEX Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation nucleosome positioning|ATP-dependent chromatin remodeling|nucleosome mobilization|chromatin organization|nucleosome disassembly|transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter DNA translocase activity RSC complex|SWI/SNF complex|nucleus
YDR396W_d YDR396W YDR396W het Dubious 0.894892747437534 0.185422212042653 no 197 0.205200319746428 682 0.001 Dubious open reading frame unlikely to encode a functional protein; extensively overlaps essential NCB2 gene encoding the beta subunit of the NC2 dimeric histone-fold complex Unknown Unknown Unknown
YOR103C YOR103C OST2 het Verified 0.894352395145945 0.185566687263455 no 198 0.196377603519633 692 0.000 FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins protein N-linked glycosylation dolichyl-diphosphooligosaccharide-protein glycotransferase activity oligosaccharyltransferase complex|integral to membrane
YOR249C YOR249C APC5 het Verified 0.893989345506751 0.185663795895031 no 199 0.21747202871087 686 0.003 FT CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION|PROTEOLYSIS NUCLEUS UBIQUITIN LIGASE COMPLEX Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to nuclear foci decreases upon DNA replication stress chromatin assembly|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination ubiquitin-protein ligase activity anaphase-promoting complex
YGL061C YGL061C DUO1 het Verified 0.890669273482789 0.186553311749139 no 200 0.153634662702478 497 0.002 FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME|CYTOSKELETON KINETOCHORE Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis mitotic spindle organization in nucleus|regulation of microtubule polymerization or depolymerization microtubule binding|structural constituent of cytoskeleton spindle microtubule|DASH complex|condensed nuclear chromosome kinetochore|spindle pole body|spindle
YOL097C YOL097C WRS1 het Verified 0.888528605859875 0.187128237741121 no 201 0.221186629689885 732 0.003 FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION Cytoplasmic tryptophanyl-tRNA synthetase, aminoacylates tryptophanyl-tRNA tryptophanyl-tRNA aminoacylation tryptophan-tRNA ligase activity cytoplasm
YKL153W_d YKL153W YKL153W het Dubious 0.885560016716822 0.187927332604504 no 202 0.186370981354857 664 0.000 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLK153W and the overlapping essential gene GPM1 is reduced in the gcr1 null mutant Unknown Unknown Unknown
YPL169C YPL169C MEX67 het Verified 0.885373110042866 0.18797771517902 no 203 0.252444494843899 894 0.001 FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE Poly(A)RNA binding protein involved in nuclear mRNA export, component of the nuclear pore; ortholog of human TAP mRNA export from nucleus|ribosomal large subunit export from nucleus protein binding|RNA binding|structural constituent of nuclear pore integral to membrane|nuclear RNA export factor complex|nuclear pore|cytoplasm
YGL092W YGL092W NUP145 het Verified 0.884704852912756 0.188157918808827 no 204 0.196511564307957 694 0.004 FT PROTEIN LOCALIZATION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE Essential protein with distinct roles in two nuclear pore subcomplexes; catalyzes its own proteolytic cleavage in vivo to generate a C-terminal fragment that is a structural component of the Nup84p subcomplex (with roles in NPC biogenesis and localization of genes to the nuclear periphery), and an N-terminal fragment that is one of several FG-nucleoporins within the NPC central core directly responsible for nucleocytoplasmic transport; homologous to human NUP98 double-strand break repair|poly(A)+ mRNA export from nucleus|maintenance of chromatin silencing at telomere|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|tRNA export from nucleus|protein targeting to nuclear inner membrane|telomere tethering at nuclear periphery|nuclear pore distribution|positive regulation of transcription, DNA-dependent|NLS-bearing substrate import into nucleus|protein import into nucleus nucleocytoplasmic transporter activity|RNA binding|structural constituent of nuclear pore nuclear pore central transport channel|integral to membrane|nuclear pore|nuclear pore outer ring
YOR341W YOR341W RPA190 het Verified 0.880914893072117 0.189181942970491 no 205 0.181930203492127 647 0.000 FT NUCLEUS RNA polymerase I largest subunit A190 transcription of nuclear large rRNA transcript from RNA polymerase I promoter DNA-directed RNA polymerase activity DNA-directed RNA polymerase I complex|nucleolus
YDR240C YDR240C SNU56 het Verified 0.880895001425029 0.189187326609833 no 206 0.215943514927688 725 0.002 FT RNA PROCESSING NUCLEUS Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart; interacts with mRNA in commitment complex mRNA splicing, via spliceosome mRNA binding commitment complex|U1 snRNP|U2-type prespliceosome
YOL010W YOL010W RCL1 het Verified 0.879280543589177 0.189624591283618 no 207 0.172848153256934 590 0.005 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Endonuclease that cleaves pre-rRNA at site A2 for 18S rRNA biogenesis; subunit of U3-containing 90S preribosome processome complex involved in small ribosomal subunit assembly; stimulates Bms1p GTPase and U3 binding activity; similar to RNA cyclase-like proteins but no cyclase activity detected endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) RNA-3'-phosphate cyclase activity|endoribonuclease activity|enzyme activator activity nucleolus|90S preribosome
YKR004C YKR004C ECM9 het Verified 0.874169421963162 0.191012997862801 no 208 0.20384976484786 681 0.002 FT CELL WALL ORG/BIOGENESIS Non-essential protein of unknown function fungal-type cell wall organization molecular_function cellular_component
YDR464W YDR464W SPP41 het Verified 0.87199923001149 0.191604398804427 no 209 0.214294581358596 731 0.006 FT TRANSCRIPTION FROM RNA POL II NUCLEUS Protein involved in negative regulation of expression of spliceosome components PRP4 and PRP3 negative regulation of transcription from RNA polymerase II promoter molecular_function nucleus
YDR489W YDR489W SLD5 het Verified 0.866465273865923 0.193117530929842 no 210 0.212300463253713 725 0.005 FT RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery double-strand break repair via break-induced replication|DNA-dependent DNA replication molecular_function GINS complex|replication fork protection complex|DNA replication preinitiation complex
YEL026W YEL026W SNU13 het Verified 0.861304412946233 0.194535202922386 no 211 0.170822766225023 594 0.002 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS RNA binding protein, part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|mRNA splicing, via spliceosome RNA binding box C/D snoRNP complex|small-subunit processome|nucleolus|U4/U6 x U5 tri-snRNP complex
YNL310C YNL310C ZIM17 het Verified 0.859427059927075 0.19505247289223 no 212 0.148629319510441 534 0.002 FT PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Heat shock protein with a zinc finger motif; essential for protein import into mitochondria; may act with Pam18p to facilitate recognition and folding of imported proteins by Ssc1p (mtHSP70) in the mitochondrial matrix protein folding|protein stabilization|protein import into mitochondrial matrix|response to unfolded protein|mitochondrion organization chaperone binding mitochondrion|mitochondrial matrix
YDR062W YDR062W LCB2 het Verified 0.857776350630976 0.195507985476526 no 213 0.203372073581131 647 0.008 FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Component of serine palmitoyltransferase, responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine sphingolipid biosynthetic process serine C-palmitoyltransferase activity SPOTS complex|serine C-palmitoyltransferase complex
YGR060W YGR060W ERG25 het Verified 0.849381221040074 0.197834599554045 no 214 0.238931068680343 798 0.006 FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol ergosterol biosynthetic process C-4 methylsterol oxidase activity plasma membrane|endoplasmic reticulum membrane
YLL037W_d YLL037W YLL037W het Dubious 0.84306900097572 0.199594927234143 no 215 0.180945381888026 643 0.005 Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential PRP19 gene encoding an RNA splicing factor Unknown Unknown Unknown
YKL165C YKL165C MCD4 het Verified 0.837814201377898 0.201067530780994 no 216 0.248905433062361 856 0.001 FF|FT LIPID METABOLISM|CELL WALL ORG/BIOGENESIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes GPI anchor biosynthetic process|ATP transport mannose-ethanolamine phosphotransferase activity integral to membrane|fungal-type cell wall|endoplasmic reticulum|fungal-type vacuole
YPR144C YPR144C NOC4 het Verified 0.836543484033923 0.201424612298869 no 217 0.21432225833383 750 0.001 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits ribosomal small subunit biogenesis|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA processing molecular_function small-subunit processome|nucleolus|nucleus|90S preribosome|Noc4p-Nop14p complex
YOR278W YOR278W HEM4 het Verified 0.835339342191785 0.201763336040441 no 218 0.226447764689984 767 0.000 FT COFACTOR METABOLISM Uroporphyrinogen III synthase, catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in heme biosynthesis; deficiency in the human homolog can result in the disease congenital erythropoietic porphyria heme biosynthetic process uroporphyrinogen-III synthase activity cellular_component
YAR007C YAR007C RFA1 het Verified 0.835042113234642 0.201846998672854 no 219 0.236816195729284 776 0.001 FT PROTEIN LOCALIZATION|CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination establishment of protein localization|telomere maintenance via telomerase|telomere maintenance via recombination|nucleotide-excision repair|DNA repair|mitotic recombination|heteroduplex formation|DNA unwinding involved in replication|reciprocal meiotic recombination|DNA replication|double-strand break repair via homologous recombination|protein ubiquitination double-stranded DNA binding|single-stranded DNA binding|sequence-specific DNA binding condensed nuclear chromosome|chromosome, telomeric region|DNA replication factor A complex|cytoplasm
YKL144C YKL144C RPC25 het Verified 0.834266487835955 0.202065415923772 no 220 0.180516221518361 613 0.002 FT NUCLEUS RNA polymerase III subunit C25, required for transcription initiation; forms a heterodimer with Rpc17p; paralog of Rpb7p transcription initiation from RNA polymerase III promoter|tRNA transcription from RNA polymerase III promoter DNA-directed RNA polymerase activity DNA-directed RNA polymerase III complex
YDL126C YDL126C CDC48 het Verified 0.832272518755951 0.202627569358117 no 221 0.196237151513246 726 0.006 FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|CHROMOSOME SEGREGATION ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION|SITE OF POLARIZED GROWTH UBIQUITIN LIGASE COMPLEX AAA ATPase involved in multiple processes; subunit of polyubiquitin-selective segregase complex involved in ERAD, cell wall integrity during heat stress, mitotic spindle disassembly; subunit of complex involved in mitochondria-associated degradation; role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing; roles in macroautophagy, PMN, RAD, ribophagy, and homotypic ER membrane fusion; functional ortholog of human p97/VCP proteasomal ubiquitin-dependent protein catabolic process|mitotic spindle disassembly|ER-associated protein catabolic process|mitochondria-associated protein catabolic process|macroautophagy|sister chromatid biorientation|ER-associated misfolded protein catabolic process|nucleus-associated proteasomal ubiquitin-dependent protein catabolic process|retrograde protein transport, ER to cytosol|piecemeal microautophagy of nucleus|endoplasmic reticulum membrane fusion|ribophagy|Unknown|cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process ubiquitin binding|ATPase activity mitochondrion|Cdc48p-Npl4p-Ufd1p AAA ATPase complex|Cdc48p-Npl4p-Vms1p AAA ATPase complex|cytosol|Doa10p ubiquitin ligase complex|nucleus|endoplasmic reticulum membrane|mating projection tip
YNL039W YNL039W BDP1 het Verified 0.825858110468836 0.204442292718744 no 222 0.212736831956513 683 0.006 FT NUCLEUS Essential subunit of RNA polymerase III transcription factor (TFIIIB), which is involved in transcription of genes encoding tRNAs, 5S rRNA, U6 snRNA, and other small RNAs DNA-dependent transcriptional open complex formation|positive regulation of transposon integration|RNA polymerase III transcriptional preinitiation complex assembly TFIIIC-class transcription factor binding|TFIIIB-type transcription factor activity transcription factor TFIIIB complex
YOL005C YOL005C RPB11 het Verified 0.819990051211278 0.206110889363889 no 223 0.207916704041719 729 0.003 FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit termination of RNA polymerase II transcription|transcription from RNA polymerase II promoter RNA-directed RNA polymerase activity|DNA-directed RNA polymerase activity DNA-directed RNA polymerase II, core complex
YPR110C YPR110C RPC40 het Verified 0.817235962261513 0.206896797344294 no 224 0.232881677758347 766 0.002 FT NUCLEUS RNA polymerase subunit AC40, common to RNA polymerase I and III tRNA transcription from RNA polymerase III promoter|transcription from RNA polymerase I promoter DNA-directed RNA polymerase activity DNA-directed RNA polymerase III complex|DNA-directed RNA polymerase I complex
YML126C YML126C ERG13 het Verified 0.814765142336378 0.207603378636763 no 225 0.186396823985943 635 0.003 FT LIPID METABOLISM ENDOPLASMIC RETICULUM 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis ergosterol biosynthetic process hydroxymethylglutaryl-CoA synthase activity endoplasmic reticulum
YPR182W YPR182W SMX3 het Verified 0.812078986299705 0.208373155054179 no 226 0.174352799374719 606 0.001 FT RNA PROCESSING NUCLEUS Core Sm protein Sm F; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm F mRNA splicing, via spliceosome molecular_function U1 snRNP|U4/U6 x U5 tri-snRNP complex|U5 snRNP
YDR303C YDR303C RSC3 het Verified 0.81085468303858 0.208724563576636 no 227 0.214759701059748 734 0.001 FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION NUCLEUS RSC COMPLEX Component of the RSC chromatin remodeling complex; essential gene required for maintenance of proper ploidy and regulation of ribosomal protein genes and the cell wall/stress response; highly similar to Rsc30p nucleosome positioning|ATP-dependent chromatin remodeling|regulation of cell cycle|nucleosome disassembly|regulation of DNA replication involved in S phase|regulation of transcription, DNA-dependent|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|transcription elongation from RNA polymerase II promoter sequence-specific DNA binding|DNA translocase activity|DNA binding RSC complex|nucleus
YFL034C-B YFL034C-B MOB2 het Verified 0.809628097170343 0.209076977274028 no 228 0.199673610931372 662 0.002 FT CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION NUCLEUS|SITE OF POLARIZED GROWTH Activator of Cbk1p kinase; component of the RAM signaling network that regulates cellular polarity and morphogenesis; activation of Cbk1p facilitates the Ace2p-dependent daughter cell-specific transcription of genes involved in cell separation; similar to Mob1p positive regulation of protein phosphorylation|establishment or maintenance of cell polarity|Unknown|budding cell apical bud growth protein kinase activator activity nucleus|cellular bud|cellular bud neck|mating projection tip|cellular bud tip
YNL131W YNL131W TOM22 het Verified 0.807903424016219 0.209573090030166 no 229 0.260237534927679 905 0.002 FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Component of the TOM (translocase of outer mitochondrial membrane) complex responsible for initial import of mitochondrially directed proteins; acts as a receptor for precursor proteins and mediates interaction between TOM and TIM complexes protein import into mitochondrial matrix|protein import into mitochondrial outer membrane protein channel activity mitochondrial outer membrane|mitochondrion|integral to membrane|integral to mitochondrial outer membrane|mitochondrial outer membrane translocase complex
YDR499W YDR499W LCD1 het Verified 0.80603225343009 0.210112126033618 no 230 0.175138658241413 620 0.002 FT PROTEIN LOCALIZATION|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p; putative homolog of S. pombe Rad26 and human ATRIP; forms nuclear foci upon DNA replication stress establishment of protein localization|telomere maintenance via telomerase|DNA damage checkpoint damaged DNA binding nuclear chromosome
YJL026W YJL026W RNR2 het Verified 0.803846613473397 0.210742782698632 no 231 0.214050585385345 749 0.001 FT OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM NUCLEUS Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits deoxyribonucleotide biosynthetic process ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor ribonucleoside-diphosphate reductase complex|nucleus|cytoplasm
YOR160W YOR160W MTR10 het Verified 0.803163488746299 0.210940122818286 no 232 0.205704164836045 733 0.001 FT PROTEIN LOCALIZATION|RNA LOCALIZATION NUCLEUS Nuclear import receptor; mediates the nuclear localization of proteins involved in mRNA-nucleus export; promotes dissociation of mRNAs from the nucleus-cytoplasm mRNA shuttling protein Npl3p; required for retrograde import of mature tRNAs; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress RNA localization|tRNA transport|RNA import into nucleus|protein import into nucleus|mRNA-binding (hnRNP) protein import into nucleus nuclear localization sequence binding integral to membrane|nucleus|cytoplasm
YNL240C YNL240C NAR1 het Verified 0.802144950254672 0.211234557911074 no 233 0.206138999588478 730 0.000 FT COFACTOR METABOLISM NUCLEUS Component of the cytosolic iron-sulfur (FeS) protein assembly machinery, required for maturation of cytosolic and nuclear FeS proteins and for normal resistance to oxidative stress; homologous to human Narf iron-sulfur cluster assembly iron-sulfur cluster binding|ferredoxin hydrogenase activity cytosol|membrane
YGL145W YGL145W TIP20 het Verified 0.801703148554739 0.211362347044723 no 234 0.208628460586706 675 0.002 FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Peripheral membrane protein required for fusion of COPI vesicles with the ER; prohibits back-fusion of COPII vesicles with the ER; forms a tethering complex with Sec39p and Dsl1p that interacts with ER SNAREs Sec20p and Use1p retrograde vesicle-mediated transport, Golgi to ER molecular_function Dsl1p complex|endoplasmic reticulum
YOR148C YOR148C SPP2 het Verified 0.79979843970425 0.211913793605973 no 235 0.193845273674084 661 0.000 FT RNA PROCESSING NUCLEUS Essential protein that promotes the first step of splicing and is required for the final stages of spliceosome maturation; interacts with Prp2p, which may release Spp2p from the spliceosome following the first cleavage reaction mRNA splicing, via spliceosome molecular_function spliceosomal complex
YPR108W YPR108W RPN7 het Verified 0.799760871561929 0.211924678697797 no 236 0.239750196622411 783 0.002 FT PROTEOLYSIS NUCLEUS Essential, non-ATPase regulatory subunit of the 26S proteasome, similar to another S. cerevisiae regulatory subunit, Rpn5p, as well as to mammalian proteasome subunits ubiquitin-dependent protein catabolic process structural molecule activity nucleus|proteasome regulatory particle, lid subcomplex
YDL163W_d YDL163W YDL163W het Dubious 0.797724271706391 0.212515257758951 no 237 0.216595889695278 737 0.004 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene CDC9/YDL164C encoding DNA ligase Unknown Unknown Unknown
YJL202C_d YJL202C YJL202C het Dubious 0.79395059392082 0.213612097086642 no 238 0.224894743232585 765 0.004 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 3' end of essential PRP21 gene encoding a subunit of the SF3a splicing factor complex Unknown Unknown Unknown
YGR075C YGR075C PRP38 het Verified 0.790141301914317 0.214722625773588 no 239 0.218779966208697 726 0.000 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING NUCLEUS Unique component of the U4/U6.U5 tri-snRNP particle, required for conformational changes which result in the catalytic activation of the spliceosome; dispensible for spliceosome assembly spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) molecular_function U4/U6 x U5 tri-snRNP complex
YDL235C YDL235C YPD1 het Verified 0.789877746670435 0.214799584321776 no 240 0.226055995300464 728 0.004 FT SIGNALING NUCLEUS Phosphorelay intermediate protein, phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus osmosensory signaling pathway via two-component system protein histidine kinase binding|transferase activity, transferring phosphorus-containing groups nucleus|cytoplasm
YNL172W YNL172W APC1 het Verified 0.786024838644249 0.215926467764546 no 241 0.181719128285354 641 0.003 FT CELL CYCLE|CELL DIVISION|PROTEOLYSIS NUCLEUS|CYTOSKELETON UBIQUITIN LIGASE COMPLEX Largest subunit of the Anaphase-Promoting Complex/Cyclosome; APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; localizes to nuclear foci that become diffuse upon DNA replication stress mitotic metaphase/anaphase transition|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|exit from mitosis|cyclin catabolic process|protein ubiquitination ubiquitin-protein ligase activity anaphase-promoting complex
YDR429C YDR429C TIF35 het Verified 0.782959705621744 0.216825387278145 no 242 0.298267610315495 995 0.003 FF|FT TRANSLATION eIF3g subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation translation reinitiation|translational initiation translation initiation factor activity eukaryotic translation initiation factor 3 complex
YDR211W YDR211W GCD6 het Verified 0.779624326739461 0.217806016313649 no 243 0.213623813404556 720 0.002 FT TRANSLATION Catalytic epsilon subunit of the translation initiation factor eIF2B; eIF2B is the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression; forms cytoplasmic foci upon DNA replication stress regulation of translational initiation guanyl-nucleotide exchange factor activity|translation initiation factor activity eukaryotic translation initiation factor 2B complex|guanyl-nucleotide exchange factor complex
YLR230W_d YLR230W YLR230W het Dubious 0.778098921324843 0.218255349292242 no 244 0.236672956356203 796 0.000 Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential CDC42 gene which encodes a small Rho-like GTPase essential for establishment and maintenance of cell polarity Unknown Unknown Unknown
YGR147C YGR147C NAT2 het Verified 0.777844447261159 0.218330360715713 no 245 0.222786567383276 760 0.000 FT MITOCHONDRION Protein with an apparent role in acetylation of N-terminal methionine residues N-terminal peptidyl-methionine acetylation molecular_function mitochondrion
YPL235W YPL235W RVB2 het Verified 0.777669287328133 0.218382001308934 no 246 0.289421461842337 963 0.003 FF|FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME ATP-dependent DNA helicase, also known as reptin; member of the AAA+ and RuvB protein families, similar to Rvb1p; conserved component of multiple complexes including the INO80 complex, the Swr1 complex, and the R2TP complex (Rvb1-Rvb2-Tah1-Pih1); involved in multiple processes such as chromatin remodeling, box C/D snoRNP assembly, and RNA polymerase II assembly regulation of transcription from RNA polymerase II promoter|rRNA processing|chromatin remodeling|box C/D snoRNP assembly|histone exchange ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 3'-5' DNA helicase activity nuclear telomeric heterochromatin|ASTRA complex|R2TP complex|Swr1 complex|nucleus|Ino80 complex
YFR005C YFR005C SAD1 het Verified 0.774683922098663 0.219263226878784 no 247 0.237258112527585 764 0.001 FT RNA PROCESSING|PROTEOLYSIS NUCLEUS Conserved zinc-finger domain protein involved in pre-mRNA splicing, required for assembly of U4 snRNA into the U4/U6 particle mRNA splicing, via spliceosome molecular_function nucleus
YMR236W YMR236W TAF9 het Verified 0.773542292280007 0.219600754747052 no 248 0.210635583144178 736 0.002 FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS RNA POL II, HOLOENZYME|HISTONE ACETYLTRANSFERASE Subunit (17 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H3 histone acetylation|RNA polymerase II transcriptional preinitiation complex assembly|chromatin modification|transcription from RNA polymerase II promoter chromatin binding|protein complex scaffold|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly SLIK (SAGA-like) complex|SAGA complex|transcription factor TFIID complex
YDR236C YDR236C FMN1 het Verified 0.771107298298588 0.220321667510559 no 249 0.19981193111953 683 0.000 FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM ENDOPLASMIC RETICULUM|MITOCHONDRION Riboflavin kinase, produces riboflavin monophosphate (FMN); FMN is a necessary cofactor for many enzymes; predominantly localizes to the microsomal fraction and also found in the mitochondrial inner membrane FMN biosynthetic process riboflavin kinase activity|FMN adenylyltransferase activity intracellular membrane-bounded organelle|mitochondrial inner membrane
YDL140C YDL140C RPO21 het Verified 0.770726480410892 0.220434536336833 no 250 0.189248612891731 679 0.005 FT TRANSCRIPTION FROM RNA POL II NUCLEUS|MITOCHONDRION RNA POL II, HOLOENZYME RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime transcription from RNA polymerase II promoter RNA-directed RNA polymerase activity|DNA-directed RNA polymerase activity mitochondrion|DNA-directed RNA polymerase II, core complex
YDL220C YDL220C CDC13 het Verified 0.766074526472525 0.221815979556152 no 251 0.224591250465972 726 0.005 FT CELL CYCLE|CELL DIVISION NUCLEUS|CHROMOSOME Single stranded DNA-binding protein found at TG1-3 telomere G-tails; regulates telomere replication through recruitment of specific sub-complexes, but the essential function is telomere capping; autophagy and proteasome are involved in Cdc13p degradation telomere capping|telomere maintenance via telomerase|negative regulation of telomerase activity|telomere maintenance|regulation of telomere maintenance via telomerase single-stranded telomeric DNA binding|telomerase inhibitor activity nuclear telomere cap complex
YML010W YML010W SPT5 het Verified 0.761153671567044 0.223282643032074 no 252 0.226573445640589 748 0.003 FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION NUCLEUS|MITOCHONDRION|CHROMOSOME Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair 7-methylguanosine mRNA capping|intracellular mRNA localization|mRNA splicing, via spliceosome|positive regulation of transcription elongation from RNA polymerase II promoter|Unknown|regulation of transcription-coupled nucleotide-excision repair core RNA polymerase I binding transcription factor activity|core RNA polymerase II binding transcription factor activity|rRNA binding|RNA polymerase II core binding|RNA polymerase I transcription factor binding|RNA polymerase I core binding DSIF complex|mitochondrion|rDNA heterochromatin|nucleus
YMR146C YMR146C TIF34 het Verified 0.757688719354024 0.224318676885343 no 253 0.206438278340767 697 0.010 FT TRANSLATION eIF3i subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates rate of ribosomal scanning during translation reinitiation translation reinitiation|translational initiation translation initiation factor activity multi-eIF complex|eukaryotic translation initiation factor 3 complex
YOR256C YOR256C TRE2 het Verified 0.747830716282449 0.227281136089305 no 254 0.227174201628229 795 0.001 FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT Transferrin receptor-like protein; functions with Tre1p to regulate ubiquitylation and vacuolar degradation of the metal transporter Smf1p; inviability of null mutant in systematic studies is due to proximity to CDC31; TRE2 has a paralog, TRE1, that arose from the whole genome duplication protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway molecular_function cellular_component
YFL008W YFL008W SMC1 het Verified 0.747262943866392 0.227452427967554 no 255 0.228250497803943 770 0.001 FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Subunit of the multiprotein cohesin complex, essential protein involved in chromosome segregation and in double-strand DNA break repair; SMC chromosomal ATPase family member, binds DNA with a preference for DNA with secondary structure double-strand break repair|mitotic sister chromatid cohesion|mitotic sister chromatid segregation double-stranded DNA binding|ATPase activity|AT DNA binding|DNA secondary structure binding nuclear mitotic cohesin complex
YJL091C YJL091C GWT1 het Verified 0.746111084816988 0.227800156874952 no 256 0.230311565451895 768 0.000 FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein involved in the inositol acylation of glucosaminyl phosphatidylinositol (GlcN-PI) to form glucosaminyl(acyl)phosphatidylinositol (GlcN(acyl)PI), an intermediate in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors GPI anchor biosynthetic process glucosaminyl-phosphotidylinositol O-acyltransferase activity integral to membrane|nuclear outer membrane-endoplasmic reticulum membrane network
YPL217C YPL217C BMS1 het Verified 0.745975151530475 0.227841212814845 no 257 0.257946147410625 899 0.006 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEOTIDE METABOLISM NUCLEUS|MITOCHONDRION GTPase required for synthesis of 40S ribosomal subunits and for processing the 35S pre-rRNA at sites A0, A1, and A2; interacts with Rcl1p, which stimulates its GTPase and U3 snoRNA binding activities; has similarity to Tsr1p ribosome assembly|rRNA processing U3 snoRNA binding|GTP binding|GTPase activity mitochondrion|nucleolus|nucleus|90S preribosome|cytoplasm
YGR090W YGR090W UTP22 het Verified 0.739561872869873 0.229782941786836 no 258 0.229266600742087 782 0.001 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Component of the small-subunit processome; required for nuclear export of tRNAs; may facilitate binding of Utp8p to aminoacylated tRNAs and their delivery to Los1p for export; conserved from yeast to mammals maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA processing molecular_function small-subunit processome|nucleolus|nucleus|UTP-C complex|90S preribosome|CURI complex
YML046W YML046W PRP39 het Verified 0.738133652295403 0.230216617918426 no 259 0.190850306800001 647 0.001 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING NUCLEUS U1 snRNP protein involved in splicing, contains multiple tetriatricopeptide repeats mRNA 5'-splice site recognition pre-mRNA 5'-splice site binding commitment complex|U1 snRNP|U2-type prespliceosome
YML093W YML093W UTP14 het Verified 0.737530697833976 0.230399841098764 no 260 0.227245100519817 777 0.015 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function small-subunit processome|nucleolus
YJR046W YJR046W TAH11 het Verified 0.722964203390284 0.234850938447899 no 261 0.255138912226111 829 0.010 FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION NUCLEUS DNA replication licensing factor, required for pre-replication complex assembly regulation of DNA-dependent DNA replication initiation|double-strand break repair via break-induced replication|pre-replicative complex assembly DNA replication origin binding|ATP binding pre-replicative complex|nucleus|cytoplasm
YDR339C YDR339C FCF1 het Verified 0.713448912558463 0.237784007626904 no 262 0.188407512701018 637 0.000 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Putative PINc domain nuclease required for early cleavages of 35S pre-rRNA and maturation of 18S rRNA; component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; copurifies with Faf1p endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function small-subunit processome|nucleolus
YPL211W YPL211W NIP7 het Verified 0.713192169203987 0.237863425650002 no 263 0.236776370111996 806 0.008 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS RIBOSOME Nucleolar protein required for 60S ribosome subunit biogenesis, constituent of 66S pre-ribosomal particles; physically interacts with Nop8p and the exosome subunit Rrp43p ribosomal large subunit assembly|ribosomal large subunit biogenesis|rRNA processing molecular_function cytosolic large ribosomal subunit|nucleolus|preribosome, large subunit precursor
YGL130W YGL130W CEG1 het Verified 0.704893599299752 0.240438226865721 no 264 0.212765981180074 718 0.001 FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS Alpha (guanylyltransferase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CET1, an RNA 5'-triphosphatase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide 7-methylguanosine mRNA capping|positive regulation of transcription from RNA polymerase II promoter mRNA guanylyltransferase activity mRNA cap methyltransferase complex|nucleus
YCR057C YCR057C PWP2 het Verified 0.704359348429565 0.240604507636528 no 265 0.277667381602816 954 0.004 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|CELL DIVISION NUCLEUS Conserved 90S pre-ribosomal component essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesis endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|establishment of cell polarity|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|cytokinesis snoRNA binding small-subunit processome|nucleolus|Pwp2p-containing subcomplex of 90S preribosome|cytoplasm|90S preribosome
YBR236C YBR236C ABD1 het Verified 0.7007735149172 0.241722184550238 no 266 0.232010451288154 762 0.007 FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS RNA POL II, HOLOENZYME Methyltransferase, catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA 7-methylguanosine mRNA capping|transcription from RNA polymerase II promoter mRNA (guanine-N7-)-methyltransferase activity nucleus|DNA-directed RNA polymerase II, holoenzyme
YKR071C YKR071C DRE2 het Verified 0.693524207929151 0.243990319646362 no 267 0.281068883823323 950 0.002 FT COFACTOR METABOLISM MITOCHONDRION Component of the cytosolic Fe-S protein assembly (CIA) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18pin an early step in the CIA pathway; ortholog of human Ciapin1; protein abundance increases in response to DNA replication stress iron-sulfur cluster assembly electron carrier activity cytosol|cytoplasm|mitochondrial intermembrane space
YOR310C YOR310C NOP58 het Verified 0.691290323546811 0.244691555772641 no 268 0.262400740403669 921 0.005 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function box C/D snoRNP complex|small-subunit processome|nucleolus|90S preribosome
YDR331W YDR331W GPI8 het Verified 0.686752007334467 0.24611950884052 no 269 0.25937376126771 887 0.004 FT LIPID METABOLISM|PROTEOLYSIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog attachment of GPI anchor to protein GPI-anchor transamidase activity endoplasmic reticulum membrane|GPI-anchor transamidase complex
YLR430W YLR430W SEN1 het Verified 0.68312690698125 0.247263327216049 no 270 0.271241615495806 951 0.007 FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Presumed helicase and subunit of the Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3' end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; has a separate role in coordinating DNA replication with transcription, by associating with moving replication forks and preventing errors that occur when forks encounter transcribed regions; homolog of Senataxin, which is implicated in Ataxia-Oculomotor Apraxia 2 and a dominant form of ALS tRNA processing|mRNA 3'-end processing|termination of RNA polymerase II transcription|mRNA polyadenylation|snoRNA 3'-end processing|rRNA processing|snRNA processing ATP-dependent 5'-3' DNA helicase activity|DNA-dependent ATPase activity|RNA-dependent ATPase activity|ATP-dependent 5'-3' RNA helicase activity|protein domain specific binding Nrd1 complex|nucleus
YNL118C YNL118C DCP2 het Verified 0.675986036093159 0.24952475542901 no 271 0.247300320742174 876 0.003 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING NUCLEUS Catalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex; removes the 5' cap structure from mRNAs prior to their degradation; nudix hydrolase family member; forms cytoplasmic foci upon DNA replication stress deadenylation-dependent decapping of nuclear-transcribed mRNA|deadenylation-independent decapping of nuclear-transcribed mRNA|stress granule assembly hydrolase activity|mRNA binding|m7G(5')pppN diphosphatase activity nucleus|cytoplasmic mRNA processing body|cytoplasm
YAR019C YAR019C CDC15 het Verified 0.672995482860031 0.250475082345904 no 272 0.251256965047465 857 0.001 FT CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION SITE OF POLARIZED GROWTH|CYTOSKELETON Protein kinase of the Mitotic Exit Network; localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II; relocalizes to the cytoplasm upon DNA replication stress regulation of exit from mitosis|protein phosphorylation|meiotic anaphase II|cytokinesis protein kinase activity spindle pole body|cellular bud neck
YIR015W YIR015W RPR2 het Verified 0.672376695230825 0.250671957599517 no 273 0.263026104008056 893 0.001 FT RNA PROCESSING NUCLEUS Subunit of nuclear RNase P; nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; not shared between RNase MRP and RNase P, in contrast to all other RNase P protein subunits; protein abundance increases in response to DNA replication stress tRNA processing|intronic box C/D snoRNA processing ribonuclease P activity nucleolar ribonuclease P complex
YDR356W YDR356W SPC110 het Verified 0.671274746552569 0.251022759597709 no 274 0.231569390440125 808 0.002 FT CYTOSKELETON ORGANIZATION NUCLEUS|CYTOSKELETON Inner plaque spindle pole body (SPB) component, ortholog of human kendrin; involved in connecting nuclear microtubules to SPB; interacts with Tub4p-complex and calmodulin; phosphorylated by Mps1p in cell cycle-dependent manner karyogamy involved in conjugation with cellular fusion|microtubule nucleation structural constituent of cytoskeleton central plaque of spindle pole body|inner plaque of spindle pole body
YIL031W YIL031W ULP2 het Verified 0.668814446761593 0.251806924972088 no 275 0.268735307906938 905 0.001 FT CELL CYCLE|PROTEOLYSIS NUCLEUS Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins, plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate plasmid maintenance|protein desumoylation|chromosome condensation|mitotic cell cycle spindle assembly checkpoint cysteine-type peptidase activity|SUMO-specific protease activity nucleus
YDL164C YDL164C CDC9 het Verified 0.667314472819519 0.252285641857217 no 276 0.233564921034046 810 0.006 FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION NUCLEUS|MITOCHONDRION|CHROMOSOME DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication; also acts in nucleotide excision repair, base excision repair, and recombination lagging strand elongation|base-excision repair|mitotic cell cycle|DNA ligation|DNA recombination|nucleotide-excision repair DNA ligase (ATP) activity mitochondrion|nucleus|replication fork
YKL013C YKL013C ARC19 het Verified 0.661376967500693 0.254185296482361 no 277 0.26552099333388 925 0.002 FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION CYTOSKELETON Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches mitochondrion inheritance|actin cortical patch assembly structural molecule activity Arp2/3 protein complex
YLR115W YLR115W CFT2 het Verified 0.659377244086757 0.254826775560051 no 278 0.254888800334588 882 0.000 FT RNA PROCESSING NUCLEUS Subunit of the mRNA cleavage and polyadenlylation factor (CPF); required for pre-mRNA cleavage, polyadenylation and poly(A) site recognition, 43% similarity with the mammalian CPSF-100 protein. mRNA cleavage|mRNA polyadenylation RNA binding mRNA cleavage factor complex|mRNA cleavage and polyadenylation specificity factor complex
YNL132W YNL132W KRE33 het Verified 0.659270883638831 0.254860917998292 no 279 0.251540201308368 859 0.018 FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS NUCLEUS Essential protein, required for biogenesis of the small ribosomal subunit; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance ribosomal small subunit biogenesis molecular_function nucleolus|90S preribosome
YDR187C_d YDR187C YDR187C het Dubious 0.641064053527467 0.260740533855012 no 280 0.288091705541876 970 0.000 FF Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF CCT6/YDR188W Unknown Unknown Unknown
YIL021W YIL021W RPB3 het Verified 0.64091308961306 0.26078957546507 no 281 0.298859027976831 1022 0.018 FF|FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME RNA polymerase II third largest subunit B44, part of central core; similar to prokaryotic alpha subunit termination of RNA polymerase II transcription|transcription from RNA polymerase II promoter RNA-directed RNA polymerase activity|DNA-directed RNA polymerase activity nucleoplasm|DNA-directed RNA polymerase II, core complex
YIL104C YIL104C SHQ1 het Verified 0.622995685644759 0.266643678492949 no 282 0.248283998224367 823 0.000 FT PROTEIN COMPLEX ORG/BIOGENESIS NUCLEUS Chaperone protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Naf1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; homology with known Hsp90p cochaperones box H/ACA snoRNP assembly unfolded protein binding nucleoplasm
YML114C YML114C TAF8 het Verified 0.622759978373629 0.266721130906349 no 283 0.264102932696511 911 0.001 FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation RNA polymerase II transcriptional preinitiation complex assembly|transcription from RNA polymerase II promoter RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly nucleus|transcription factor TFIID complex
YDR413C_d YDR413C YDR413C het Dubious 0.621781972559744 0.267042620917476 no 284 0.280270167519196 947 0.003 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the essential uncharacterized ORF YDR412W that is implicated in rRNA processing Unknown Unknown Unknown
YJL085W YJL085W EXO70 het Verified 0.618639953348529 0.268076787686637 no 285 0.272803713008152 947 0.004 FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION SITE OF POLARIZED GROWTH Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in an actin-independent manner, targeting and anchoring the exocyst with Sec3p; involved in exocyst assembly; direct downstream effector of Rho3p and Cdc42p; relocalizes from bud neck to cytoplasm upon DNA replication stress Golgi to plasma membrane transport|exocytosis|exocyst localization|exocyst assembly|vesicle fusion|vesicle docking involved in exocytosis Rho GTPase binding|phosphatidylinositol-4,5-bisphosphate binding incipient cellular bud site|cellular bud neck|mating projection tip|cellular bud tip|exocyst
YPL242C YPL242C IQG1 het Verified 0.614678362292235 0.269383576093799 no 286 0.26094010135587 885 0.006 FT CELL CYCLE|SIGNALING|CELL DIVISION|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Essential protein required for determination of budding pattern; promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family; relocalizes from bud neck to cytoplasm upon DNA replication stress actin filament organization|response to osmotic stress|cytokinesis cytoskeletal protein binding cellular bud neck contractile ring
YDL030W YDL030W PRP9 het Verified 0.608289053523241 0.271497889920404 no 287 0.264096199662116 893 0.001 FT RNA PROCESSING NUCLEUS Subunit of the SF3a splicing factor complex, required for spliceosome assembly; acts after the formation of the U1 snRNP-pre-mRNA complex mRNA splicing, via spliceosome RNA binding U2 snRNP|U2-type prespliceosome
YBR121C YBR121C GRS1 het Verified 0.607718976467087 0.271686937467444 no 288 0.264638301251003 892 0.002 FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Cytoplasmic and mitochondrial glycyl-tRNA synthase; ligates glycine to the cognate anticodon-bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation; GRS1 has a paralog, GRS2, that arose from the whole genome duplication mitochondrial glycyl-tRNA aminoacylation|glycyl-tRNA aminoacylation|DNA-dependent transcription, termination glycine-tRNA ligase activity mitochondrion|cytoplasm
YPR082C YPR082C DIB1 het Verified 0.606156346900117 0.272205468585279 no 289 0.28726169536936 946 0.002 FT CELL CYCLE|RNA PROCESSING|CELL DIVISION NUCLEUS 17-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing, orthologue of hDIM1, the human U5-specific 15-kDa protein mRNA splicing, via spliceosome molecular_function U4/U6 x U5 tri-snRNP complex|U5 snRNP
YJR012C_p YJR012C YJR012C het Uncharacterized 0.603953495737304 0.272937280397005 no 290 0.244303109399127 854 0.007 Essential protein of unknown function; proposed involvement in transport based on mass spectrometry analysis of copurifying proteins; partially overlaps neighboring ORF, GPI14/YJR013W biological_process molecular_function cellular_component
YHR170W YHR170W NMD3 het Verified 0.596867672842558 0.27529786595606 no 291 0.340319135711477 1164 0.018 FF|FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS NUCLEUS RIBOSOME Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex ribosomal large subunit export from nucleus ribosomal large subunit binding cytosol|cytosolic large ribosomal subunit
YCR093W YCR093W CDC39 het Verified 0.579222900914004 0.281219390156214 no 292 0.307024757975477 1034 0.006 FF|FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RNA PROCESSING NUCLEUS Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor response to pheromone involved in conjugation with cellular fusion|regulation of cell cycle|regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|pseudohyphal growth|negative regulation of transcription from RNA polymerase II promoter|nuclear-transcribed mRNA poly(A) tail shortening|transcription elongation from RNA polymerase II promoter molecular_function CCR4-NOT core complex|nucleus|cytoplasm
YCL059C YCL059C KRR1 het Verified 0.573327891851664 0.283211351801761 no 293 0.252082919056848 883 0.003 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Essential nucleolar protein required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunit endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal small subunit biogenesis|rRNA processing molecular_function small-subunit processome|nucleolus|90S preribosome
YPL228W YPL228W CET1 het Verified 0.570258483239717 0.284251197553401 no 294 0.284163188431446 970 0.007 FT RNA PROCESSING NUCLEUS Beta (RNA 5'-triphosphatase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CEG1, a guanylyltransferase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide 7-methylguanosine mRNA capping polynucleotide 5'-phosphatase activity mRNA cap methyltransferase complex|nucleus
YLL034C YLL034C RIX7 het Verified 0.563329164015435 0.28660538129762 no 295 0.261338784103233 870 0.001 FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS NUCLEUS Putative ATPase of the AAA family, required for export of pre-ribosomal large subunits from the nucleus; distributed between the nucleolus, nucleoplasm, and nuclear periphery depending on growth conditions ribosomal large subunit biogenesis|ribosomal large subunit export from nucleus ATPase activity nucleolus|nucleus|preribosome, large subunit precursor
YGL047W YGL047W ALG13 het Verified 0.562375497106089 0.28693010495211 no 296 0.28259017746468 951 0.002 FT LIPID METABOLISM|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Catalytic component of UDP-GlcNAc transferase; required for the second step of dolichyl-linked oligosaccharide synthesis; anchored to the ER membrane via interaction with Alg14p; similar to bacterial and human glycosyltransferases; protein abundance increases in response to DNA replication stress dolichol-linked oligosaccharide biosynthetic process N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity cytosol|UDP-N-acetylglucosamine transferase complex|extrinsic to endoplasmic reticulum membrane|endoplasmic reticulum|nucleus|cytoplasm
YHR166C YHR166C CDC23 het Verified 0.560754979026062 0.287482290878738 no 297 0.275010949830848 914 0.000 FT CELL CYCLE|CELL DIVISION|PROTEOLYSIS NUCLEUS|CHROMOSOME UBIQUITIN LIGASE COMPLEX Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination ubiquitin-protein ligase activity|cyclin binding anaphase-promoting complex
YDR472W YDR472W TRS31 het Verified 0.560477038173629 0.287577048723993 no 298 0.310390016021926 1052 0.003 FT VESICLE-MEDIATED TRANSPORT ENDOPLASMIC RETICULUM|GOLGI APPARATUS One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic ER to Golgi vesicle-mediated transport Rab guanyl-nucleotide exchange factor activity TRAPP complex
YFL045C YFL045C SEC53 het Verified 0.557373346666755 0.288636186032817 no 299 0.285356657291939 958 0.003 FT PROTEIN LOCALIZATION|CARBOHYDRATE METABOLISM Phosphomannomutase, involved in synthesis of GDP-mannose and dolichol-phosphate-mannose; required for folding and glycosylation of secretory proteins in the ER lumen protein targeting to ER phosphomannomutase activity cytosol
YNL308C YNL308C KRI1 het Verified 0.55460783692971 0.28958146371497 no 300 0.297516490007867 1032 0.001 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Essential nucleolar protein required for 40S ribosome biogenesis; associate with snR30; physically and functionally interacts with Krr1p endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function nucleolus
YDR280W YDR280W RRP45 het Verified 0.553593122567396 0.289928666915781 no 301 0.382409974395315 1304 0.001 FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress U5 snRNA 3'-end processing|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nonfunctional rRNA decay|nuclear polyadenylation-dependent mRNA catabolic process|U4 snRNA 3'-end processing|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|polyadenylation-dependent snoRNA 3'-end processing|U1 snRNA 3'-end processing|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|nuclear-transcribed mRNA catabolic process, non-stop decay molecular_function nucleolus|nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)
YPR033C YPR033C HTS1 het Verified 0.552580553869085 0.290275330412276 no 302 0.245908785977417 871 0.010 FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Cytoplasmic and mitochondrial histidine tRNA synthetase; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence; mutations in human ortholog HARS2 are associated with Perrault syndrome histidyl-tRNA aminoacylation|mitochondrial translation aminoacyl-tRNA ligase activity mitochondrion|cytoplasm
YNR038W YNR038W DBP6 het Verified 0.542165589682254 0.293852218944964 no 303 0.300372040932532 1004 0.007 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Essential protein involved in ribosome biogenesis; putative ATP-dependent RNA helicase of the DEAD-box protein family maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ATP-dependent RNA helicase activity nucleolus|preribosome, large subunit precursor
YML091C YML091C RPM2 het Verified 0.535070238989214 0.29630064425286 no 304 0.324354781950367 1109 0.002 FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|TRANSLATION|MITOCHONDRION ORGANIZATION NUCLEUS|MITOCHONDRION Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus cytoplasmic translation|tRNA 5'-leader removal|mRNA processing|mitochondrion organization|RNA processing|positive regulation of transcription from RNA polymerase II promoter ribonuclease P activity mitochondrion|nucleus|mitochondrial matrix|cytoplasmic mRNA processing body|mitochondrial ribonuclease P complex
YGR280C YGR280C PXR1 het Verified 0.532745085189638 0.297105026088278 no 305 0.29056649481748 944 0.004 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain box C/D snoRNA 3'-end processing|negative regulation of telomere maintenance via telomerase telomerase inhibitor activity nucleoplasm|nucleolus
YPR025C YPR025C CCL1 het Verified 0.52863900902147 0.298527947096167 no 306 0.298919732225333 1009 0.001 FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|PROTEIN PHOSPHORYLATION NUCLEUS|MITOCHONDRION RNA POL II, HOLOENZYME Cyclin associated with protein kinase Kin28p, which is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters phosphorylation of RNA polymerase II C-terminal domain|transcription from RNA polymerase II promoter core RNA polymerase binding transcription factor activity|cyclin-dependent protein kinase regulator activity mitochondrion|holo TFIIH complex|TFIIK complex
YOR217W YOR217W RFC1 het Verified 0.52757399904143 0.298897521706324 no 307 0.323671176418087 1096 0.002 FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION NUCLEUS|CHROMOSOME Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon DNA repair|mismatch repair|mitotic cell cycle|leading strand elongation DNA clamp loader activity DNA replication factor C complex
YGL048C YGL048C RPT6 het Verified 0.525487101021453 0.29962230895889 no 308 0.294100729147715 1014 0.000 FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEOLYSIS NUCLEUS ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; bound by ubiquitin-protein ligases Ubr1p and Ufd4p; localized mainly to the nucleus throughout the cell cycle; protein abundance increases in response to DNA replication stress proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|nucleotide-excision repair|proteasome regulatory particle assembly|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|negative regulation of sequence-specific DNA binding transcription factor activity|chromatin remodeling ATPase activity|protein domain specific binding proteasome regulatory particle, base subcomplex|proteasome storage granule|nucleus
YOR056C YOR056C NOB1 het Verified 0.52536145850388 0.299665970464783 no 309 0.31330404156351 1050 0.000 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS|ENDOPLASMIC RETICULUM Protein involved in proteasomal and 40S ribosomal subunit biogenesis; required for cleavage of the 20S pre-rRNA to generate the mature 18S rRNA; cleavage is activated by Fun12p, a GTPase and translation initiation factor; relocalizes from nucleus to nucleolus upon DNA replication stress proteasome assembly|ribosomal small subunit biogenesis|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of SSU-rRNA endoribonuclease activity|SSU rRNA binding preribosome, small subunit precursor|nucleus|cytoplasm
YDR047W YDR047W HEM12 het Verified 0.525055006379583 0.299772476447797 no 310 0.276758313247801 940 0.005 FF|FT COFACTOR METABOLISM NUCLEUS Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda heme biosynthetic process uroporphyrinogen decarboxylase activity nucleus|cytoplasm
YIL143C YIL143C SSL2 het Verified 0.519965631638693 0.301543764770581 no 311 0.286026133567506 968 0.003 FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|RNA LOCALIZATION NUCLEUS RNA POL II, HOLOENZYME Component of RNA polymerase transcription factor TFIIH holoenzyme; has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; interacts functionally with TFIIB and has roles in transcription start site selection and in gene looping to juxtapose initiation and termination regions; involved in DNA repair; homolog of human ERCC3 poly(A)+ mRNA export from nucleus|promoter clearance from RNA polymerase II promoter|transcriptional open complex formation at RNA polymerase II promoter|nucleotide-excision repair, DNA incision|transcription from RNA polymerase II promoter|phosphorylation of RNA polymerase II C-terminal domain|regulation of transposition, RNA-mediated|regulation of mitotic recombination ATP-dependent DNA helicase activity|core RNA polymerase binding transcription factor activity core TFIIH complex|holo TFIIH complex|nucleotide-excision repair factor 3 complex
YLR086W YLR086W SMC4 het Verified 0.517087739553213 0.302547455930246 no 312 0.315248757832306 1071 0.004 FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Subunit of the condensin complex; reorganizes chromosomes during cell division; forms a complex with Smc2p that has ATP-hydrolyzing and DNA-binding activity; required for tRNA gene clustering at the nucleolus; potential Cdc28p substrate mitotic chromosome condensation|mitotic sister chromatid segregation|tRNA gene clustering chromatin binding|ATPase activity SMC loading complex|nuclear condensin complex
YDR311W YDR311W TFB1 het Verified 0.513107072267028 0.303938212338924 no 313 0.320887222689609 1092 0.007 FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION NUCLEUS RNA POL II, HOLOENZYME Subunit of TFIIH and nucleotide excision repair factor 3 complexes, required for nucleotide excision repair, target for transcriptional activators phosphorylation of RNA polymerase II C-terminal domain|transcription from RNA polymerase I promoter|nucleotide-excision repair|transcription from RNA polymerase II promoter core RNA polymerase binding transcription factor activity|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-5-phosphate binding core TFIIH complex|holo TFIIH complex|nucleotide-excision repair factor 3 complex
YDR081C YDR081C PDC2 het Verified 0.505947357188704 0.306446802937172 no 314 0.355284832045931 1191 0.001 FT TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Transcription factor for thiamine-regulated genes; required for expression of the two isoforms of pyruvate decarboxylase (PDC1 and PDC5) along with thiamine biosynthetic genes; binds a DNA sequence in the PDC5 promoter; mutant fails to grow on 2% glucose and thus is scored as inviable under standard conditions positive regulation of thiamine biosynthetic process|Unknown|positive regulation of transcription from RNA polymerase II promoter transcription regulatory region sequence-specific DNA binding nucleus
YOR181W YOR181W LAS17 het Verified 0.505116783111812 0.306738407086348 no 315 0.300029428067673 1018 0.012 FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Actin assembly factor, activates the Arp2/3 protein complex that nucleates branched actin filaments; localizes with the Arp2/3 complex to actin patches; homolog of the human Wiskott-Aldrich syndrome protein (WASP) bipolar cellular bud site selection|endocytosis|actin polymerization or depolymerization|actin filament organization|actin cortical patch localization|positive regulation of actin filament bundle assembly|response to osmotic stress|cytokinesis cytoskeletal protein binding mating projection tip|cytoplasm|actin cortical patch
YKL078W YKL078W DHR2 het Verified 0.493079382680518 0.310978249028009 no 316 0.305177193520122 1050 0.002 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Predominantly nucleolar DEAH-box ATP-dependent RNA helicase, required for 18S rRNA synthesis maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosome biogenesis RNA helicase activity nucleolus
YLR229C YLR229C CDC42 het Verified 0.490840927118616 0.311769480326117 no 317 0.317891328355521 1090 0.008 FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|SIGNALING|CELL DIVISION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins budding cell apical bud growth|Rho protein signal transduction|budding cell isotropic bud growth|regulation of initiation of mating projection growth|regulation of vacuole fusion, non-autophagic|regulation of exit from mitosis|pheromone-dependent signal transduction involved in conjugation with cellular fusion|pseudohyphal growth|establishment of cell polarity|invasive growth in response to glucose limitation|positive regulation of exocytosis GTPase activity|signal transducer activity nuclear membrane|fungal-type vacuole membrane|incipient cellular bud site|plasma membrane|cellular bud neck|mating projection tip|cellular bud tip
YDL028C YDL028C MPS1 het Verified 0.482558064469345 0.314704780508911 no 318 0.330012893072517 1095 0.001 FT PROTEIN LOCALIZATION|CELL CYCLE|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME|CYTOSKELETON KINETOCHORE Dual-specificity kinase; required for spindle pole body (SPB) duplication and spindle checkpoint function; substrates include SPB proteins Spc42p, Spc110p, and Spc98p, mitotic exit network protein Mob1p, kinetochore protein Cnn1p, and checkpoint protein Mad1p protein phosphorylation|sister chromatid biorientation|spindle assembly|spindle pole body duplication associated with nuclear envelope|mitotic cell cycle spindle assembly checkpoint protein serine/threonine/tyrosine kinase activity|protein kinase activity condensed nuclear chromosome kinetochore|spindle pole body
YBR265W YBR265W TSC10 het Verified 0.481190334337333 0.315190614916991 no 319 0.327554997530804 1098 0.001 FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION 3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis, essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine, member of short chain dehydrogenase/reductase protein family 3-keto-sphinganine metabolic process|sphingolipid biosynthetic process oxidoreductase activity, acting on NADH or NADPH mitochondrial outer membrane|endoplasmic reticulum|cytoplasm
YJL061W YJL061W NUP82 het Verified 0.47977804759141 0.315692612020251 no 320 0.306175692172007 1037 0.001 FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup159p, and Nup116p) mRNA export from nucleus|protein export from nucleus|ribosomal large subunit export from nucleus|protein import into nucleus|ribosomal small subunit export from nucleus structural constituent of nuclear pore integral to membrane|nuclear pore cytoplasmic filaments|nuclear pore linkers|nuclear pore
YDL166C YDL166C FAP7 het Verified 0.478513860486758 0.316142255761203 no 321 0.326319149437444 1116 0.001 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|RESPONSE TO OXIDATIVE STRESS NUCLEUS Essential NTPase required for small ribosome subunit synthesis, mediates processing of the 20S pre-rRNA at site D in the cytoplasm but associates only transiently with 43S preribosomes via Rps14p, may be the endonuclease for site D cellular response to oxidative stress|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal small subunit export from nucleus nucleoside-triphosphatase activity nucleus|preribosome|cytoplasm
YLR026C YLR026C SED5 het Verified 0.47701885869213 0.316674346339067 no 322 0.307563041113892 1029 0.002 FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|GOLGI APPARATUS cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|vesicle fusion with Golgi apparatus|vesicle fusion SNAP receptor activity SNARE complex|integral to membrane|cis-Golgi network
YGR186W YGR186W TFG1 het Verified 0.475328216829424 0.317276525067242 no 323 0.332505097075381 1102 0.001 FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME TFIIF (Transcription Factor II) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74 transcription initiation from RNA polymerase II promoter|transcriptional start site selection at RNA polymerase II promoter|dephosphorylation of RNA polymerase II C-terminal domain|promoter clearance from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|regulation of protein serine/threonine phosphatase activity core RNA polymerase II binding transcription factor activity|protein phosphatase activator activity|core RNA polymerase II recruiting transcription factor activity transcription factor TFIIF complex
YGL172W YGL172W NUP49 het Verified 0.474632026854812 0.317524637243669 no 324 0.348375945902418 1181 0.003 FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup57p) poly(A)+ mRNA export from nucleus|ribosomal large subunit export from nucleus|protein import into nucleus|tRNA export from nucleus nucleocytoplasmic transporter activity|structural constituent of nuclear pore nuclear pore central transport channel|nuclear envelope|integral to membrane|nuclear pore
YLR321C YLR321C SFH1 het Verified 0.471757038703344 0.318550109474601 no 325 0.354022465945319 1185 0.006 FF|FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME RSC COMPLEX Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog ATP-dependent chromatin remodeling|double-strand break repair|chromosome segregation|regulation of DNA replication involved in S phase|chromatin remodeling at centromere|nucleosome disassembly|G2/M transition of mitotic cell cycle|transcription elongation from RNA polymerase II promoter DNA translocase activity RSC complex
YOR236W YOR236W DFR1 het Verified 0.466067232388473 0.320583688539995 no 326 0.315276249259361 1114 0.002 FF|FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism tetrahydrofolate biosynthetic process|dihydrofolate metabolic process dihydrofolate reductase activity|mRNA binding cytosol
YPL255W YPL255W BBP1 het Verified 0.464420142565299 0.321173380795508 no 327 0.354206140992908 1142 0.003 FT CELL CYCLE|CYTOSKELETON ORGANIZATION NUCLEUS|CYTOSKELETON Protein required for the spindle pole body (SPB) duplication, localized at the central plaque periphery; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p microtubule nucleation|spindle pole body duplication associated with nuclear envelope structural constituent of cytoskeleton spindle pole body
YHR164C YHR164C DNA2 het Verified 0.461675834362068 0.322156901610658 no 328 0.300699712417474 1031 0.001 FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Tripartite DNA replication factor; has single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; required for Okazaki fragment processing; involved in DNA repair; cell-cycle dependent localization; forms nuclear foci upon DNA replication stress DNA repair|lagging strand elongation|meiotic DNA double-strand break processing|DNA strand renaturation|replicative cell aging|telomere maintenance|DNA-dependent DNA replication ATP-dependent DNA helicase activity|single-stranded DNA specific endodeoxyribonuclease activity|5'-flap endonuclease activity nuclear chromosome, telomeric region|nucleus|cytoplasm
YFL029C YFL029C CAK1 het Verified 0.460860705697503 0.322449272512479 no 329 0.34561518758114 1148 0.003 FT CELL CYCLE|PROTEIN PHOSPHORYLATION Cyclin-dependent kinase-activating kinase required for passage through the cell cycle, phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases G2/M transition of mitotic cell cycle|meiosis|G1 phase of mitotic cell cycle|protein phosphorylation cyclin-dependent protein kinase activating kinase activity cytoplasm
YML098W YML098W TAF13 het Verified 0.458025316579359 0.323467126467438 no 330 0.308325468544559 1028 0.006 FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME TFIID subunit (19 kDa), involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors RNA polymerase II transcriptional preinitiation complex assembly|transcription from RNA polymerase II promoter RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly nucleus|transcription factor TFIID complex
YDR412W YDR412W RRP17 het Verified 0.452228055062583 0.325552349584737 no 331 0.285235417137632 971 0.002 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Component of the pre-60S pre-ribosomal particle; required for cell viability under standard (aerobic) conditions but not under anaerobic conditions; exonuclease required for 5′ end processing of pre-60S ribosomal RNA rRNA processing molecular_function cytoplasm
YOR257W YOR257W CDC31 het Verified 0.449756444478492 0.326443033431484 no 332 0.329023743975697 1119 0.001 FF|FT PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|PROTEOLYSIS|CYTOSKELETON ORGANIZATION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON NUCLEAR PORE Calcium-binding component of the spindle pole body (SPB) half-bridge, required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation microtubule nucleation|proteasomal ubiquitin-dependent protein catabolic process|spindle pole body duplication associated with nuclear envelope structural constituent of cytoskeleton integral to membrane|transcription export complex 2|nucleotide-excision repair factor 2 complex|half bridge of spindle pole body|nuclear pore
YHR058C YHR058C MED6 het Verified 0.44865455378997 0.326840436649302 no 333 0.337455592693686 1146 0.003 FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; protein abundance increases in response to DNA replication stress RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly core mediator complex
YIL075C YIL075C RPN2 het Verified 0.445963928649985 0.327811651087465 no 334 0.292317748413441 1001 0.004 FT PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS NUCLEUS Subunit of the 26S proteasome; substrate of the N-acetyltransferase Nat1p; protein abundance increases in response to DNA replication stress proteasome assembly|ubiquitin-dependent protein catabolic process endopeptidase activity|protein binding, bridging proteasome regulatory particle, base subcomplex|nucleus|proteasome storage granule
YBR160W YBR160W CDC28 het Verified 0.441973126223057 0.329254326373554 no 335 0.31523491591006 1076 0.002 FT CELL CYCLE|LIPID METABOLISM|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION NUCLEUS|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH|CYTOSKELETON Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK); alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates; involved in modulating membrane trafficking dynamics; protein abundance increases in response to DNA replication stress regulation of budding cell apical bud growth|negative regulation of meiotic cell cycle|positive regulation of triglyceride catabolic process|protein phosphorylation|regulation of filamentous growth|negative regulation of transcription, DNA-dependent|positive regulation of meiotic cell cycle|positive regulation of transcription, DNA-dependent|regulation of double-strand break repair via homologous recombination|vesicle-mediated transport|positive regulation of DNA replication involved in S phase|positive regulation of mitotic cell cycle|positive regulation of spindle pole body separation|chromatin remodeling|negative regulation of mitotic cell cycle histone binding|protein kinase activity|cyclin-dependent protein kinase activity cyclin-dependent protein kinase holoenzyme complex|ribosome|endoplasmic reticulum|nucleus|spindle pole body|cellular bud neck|astral microtubule|cytoplasm
YPL151C YPL151C PRP46 het Verified 0.440223696403131 0.329887549377171 no 336 0.29154367995879 980 0.002 FT CELL CYCLE|RNA PROCESSING NUCLEUS Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs mRNA splicing, via spliceosome molecular_function Prp19 complex|spliceosomal complex
YKL195W YKL195W MIA40 het Verified 0.438722252570885 0.330431400545785 no 337 0.360987501458477 1219 0.003 FF|FT PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Oxidoreductase that mediates mitochondrial intermembrane space import; substrates include small proteins containing twin cysteine motifs; acts in concert with Erv1p, which oxidizes the cysteine residues of Mia40p to comprise a disulfide relay system that catalyzes import; also mediates folding of Atp23p protein import into mitochondrial intermembrane space molecular_function mitochondrion|mitochondrial inner membrane|mitochondrial outer membrane translocase complex|mitochondrial intermembrane space
YGR246C YGR246C BRF1 het Verified 0.43590958384841 0.331451165689975 no 338 0.300227647375332 1020 0.001 FT TRANSLATION NUCLEUS TFIIIB B-related factor, one of three subunits of RNA polymerase III transcription initiation factor TFIIIB, binds TFIIIC and TBP and recruits RNA pol III to promoters, amino-terminal half is homologous to TFIIB DNA-dependent transcriptional open complex formation|transposon integration|RNA polymerase III transcriptional preinitiation complex assembly|negative regulation of protein homodimerization activity TFIIIC-class transcription factor binding|RNA polymerase III core binding|DNA binding|TFIIIB-type transcription factor activity transcription factor TFIIIB complex
YLR298C YLR298C YHC1 het Verified 0.435093373893455 0.331747326414394 no 339 0.322369192321279 1101 0.005 FT RNA PROCESSING NUCLEUS Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice site mRNA splicing, via spliceosome mRNA binding commitment complex|U1 snRNP|U2-type prespliceosome
YMR301C YMR301C ATM1 het Verified 0.430528826907528 0.333405500933059 no 340 0.34192354979528 1172 0.000 FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS MITOCHONDRION Mitochondrial inner membrane ATP-binding cassette (ABC) transporter, exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol cellular iron ion homeostasis ATPase activity, coupled to transmembrane movement of substances|ATPase activity mitochondrion|integral to membrane|mitochondrial inner membrane
YOL127W YOL127W RPL25 het Verified 0.430192806728079 0.333527697073548 no 341 0.359504373746683 1216 0.004 FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal 60S subunit protein L25; primary rRNA-binding ribosomal protein component of large ribosomal subunit; binds to 25S rRNA via a conserved C-terminal motif; homologous to mammalian ribosomal protein L23A and bacterial L23 cytoplasmic translation|ribosomal large subunit assembly structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YML085C YML085C TUB1 het Verified 0.425941415584251 0.335075267730343 no 342 0.334106568644899 1143 0.012 FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|NUCLEOTIDE METABOLISM|CHROMOSOME SEGREGATION NUCLEUS|CYTOSKELETON Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; relative distribution to nuclear foci increases upon DNA replication stress; TUB1 has a paralog, TUB3, that arose from the whole genome duplication nuclear migration along microtubule|nuclear migration involved in conjugation with cellular fusion|homologous chromosome segregation|mitotic sister chromatid segregation structural constituent of cytoskeleton tubulin complex|cytoplasmic microtubule|kinetochore microtubule|nuclear microtubule|spindle pole body|polar microtubule
YNL262W YNL262W POL2 het Verified 0.413655237218402 0.339563306867836 no 343 0.310476596348659 1033 0.005 FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|GENE SILENCING NUCLEUS|CHROMOSOME Catalytic subunit of DNA polymerase (II) epsilon, a chromosomal DNA replication polymerase that exhibits processivity and proofreading exonuclease activity; also involved in DNA synthesis during DNA repair; interacts extensively with Mrc1p DNA replication involved in S phase|double-strand break repair via nonhomologous end joining|DNA synthesis involved in DNA repair|DNA-dependent DNA replication|mitotic cell cycle DNA replication checkpoint|mitotic sister chromatid cohesion|chromatin silencing at telomere double-stranded DNA binding|single-stranded DNA binding|DNA-directed DNA polymerase activity replication fork|epsilon DNA polymerase complex
YBR234C YBR234C ARC40 het Verified 0.408524730061245 0.341444239215284 no 344 0.340447922599761 1137 0.007 FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION CYTOSKELETON Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches mitochondrion inheritance|actin nucleation|actin filament organization ubiquitin binding Arp2/3 protein complex
YOR218C_d YOR218C YOR218C het Dubious 0.401346532521598 0.344082504340632 no 345 0.328937129043923 1079 0.004 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene RFC1/YOR217W Unknown Unknown Unknown
YDL008W YDL008W APC11 het Verified 0.397702050372257 0.345424912930816 no 346 0.325188159415741 1063 0.001 FT CELL CYCLE|CELL DIVISION|PROTEOLYSIS NUCLEUS UBIQUITIN LIGASE COMPLEX Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; contains a RING-H2 domain that is required for activity anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination ubiquitin-protein ligase activity anaphase-promoting complex
YLR316C YLR316C TAD3 het Verified 0.397089440529498 0.345650753211284 no 347 0.350761047684299 1150 0.002 FT RNA PROCESSING NUCLEUS Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad2p that converts adenosine to inosine at the wobble position of several tRNAs tRNA modification tRNA-specific adenosine deaminase activity nucleus|cytoplasm
YOL026C YOL026C MIM1 het Verified 0.395279195422697 0.346318425774139 no 348 0.338319333285529 1155 0.001 FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial protein required for outer membrane protein import; cooperates with Tom70p to import the subset of proteins with multiple alpha-helical transmembrane segments, including Ugo1p, Tom20p, and others; present in a complex with Mim2p in the outer membrane that may create a local environment to facilitate membrane insertion of substrate proteins; also has a role in assembly of Tom20p into the TOM complex mitochondrial outer membrane translocase complex assembly|protein import into mitochondrial outer membrane molecular_function mitochondrial outer membrane|integral to mitochondrial outer membrane
YAL034C-B_d YAL034C-B YAL034C-B het Dubious 0.394657554693897 0.346547815809057 no 349 0.35658856490685 1183 0.004 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOL133W YOL133W HRT1 het Verified 0.390340868024992 0.34814225349763 no 350 0.354065827656709 1200 0.009 FT CELL CYCLE|PROTEOLYSIS NUCLEUS UBIQUITIN LIGASE COMPLEX RING finger containing subunit of Skp1-Cullin-F-box ubiquitin protein ligases (SCF); required for Gic2p, Far1p, Sic1p and Cln2p degradation; may tether Cdc34p (a ubiquitin conjugating enzyme or E2) and Cdc53p (a cullin) subunits of SCF G2/M transition of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|G1/S transition of mitotic cell cycle ubiquitin-protein ligase activity SCF ubiquitin ligase complex|nucleus|cytoplasm
YOR149C YOR149C SMP3 het Verified 0.380976126036753 0.351610481852046 no 351 0.322905508082536 1099 0.006 FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Alpha 1,2-mannosyltransferase involved in glycosyl phosphatidyl inositol (GPI) biosynthesis; required for addition of the fourth, side branching mannose to the GPI core structure GPI anchor biosynthetic process|plasmid maintenance dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity integral to membrane|endoplasmic reticulum
YKR063C YKR063C LAS1 het Verified 0.375448304402374 0.353663543069121 no 352 0.350693665970422 1160 0.000 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS|MITOCHONDRION Protein required for pre-rRNA processing at both ends of ITS2; may coordinate the action of the Rat1p-Rai1p exoRNAse; required for the G1/S transition of the cell cycle; human ortholog is Las1L; mutants require the SSD1-v allele for viability maturation of LSU-rRNA|maturation of 5.8S rRNA molecular_function mitochondrion|nucleus|preribosome|cytoplasm
YDR060W YDR060W MAK21 het Verified 0.375371987482532 0.353691917537657 no 353 0.363180853378443 1215 0.010 FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS NUCLEUS Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein ribosomal large subunit assembly molecular_function Noc1p-Noc2p complex
YPL007C YPL007C TFC8 het Verified 0.365866881424151 0.357232205152121 no 354 0.341026567584238 1148 0.001 FT NUCLEUS One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; linker between TauB and TauA domains; human homolog is TFIIIC-90 transcription from a RNA polymerase III hybrid type promoter|transcription from RNA polymerase III type 2 promoter|5S class rRNA transcription from RNA polymerase III type 1 promoter|transcription from RNA polymerase III promoter RNA polymerase III type 1 promoter sequence-specific DNA binding|RNA polymerase III type 2 promoter sequence-specific DNA binding|RNA polymerase III type 2 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity|RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity|DNA binding, bending transcription factor TFIIIC complex
YJR016C YJR016C ILV3 het Verified 0.365282777072096 0.357450166692835 no 355 0.34594661172077 1146 0.003 FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids branched-chain amino acid biosynthetic process dihydroxy-acid dehydratase activity mitochondrion
YHR172W YHR172W SPC97 het Verified 0.362562775897494 0.358465760647018 no 356 0.36715016638302 1206 0.000 FT CYTOSKELETON ORGANIZATION NUCLEUS|CYTOSKELETON Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque microtubule nucleation structural constituent of cytoskeleton outer plaque of spindle pole body|gamma-tubulin small complex, spindle pole body|inner plaque of spindle pole body
YER126C YER126C NSA2 het Verified 0.362415640798436 0.358520726572627 no 357 0.358643939407974 1153 0.000 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Protein constituent of 66S pre-ribosomal particles, contributes to processing of the 27S pre-rRNA maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal large subunit biogenesis|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function nucleus|preribosome, large subunit precursor
YGL123W YGL123W RPS2 het Verified 0.362279052899459 0.358571754956384 no 358 0.4095220065091 1359 0.007 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION NUCLEUS RIBOSOME Protein component of the small (40S) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p; homologous to mammalian ribosomal protein S2 and bacterial S5 positive regulation of translational fidelity|rRNA export from nucleus structural constituent of ribosome|SSU rRNA binding small-subunit processome|cytosolic small ribosomal subunit
YFR031C YFR031C SMC2 het Verified 0.355637408595923 0.361056062407096 no 359 0.353744841334041 1180 0.005 FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION|CHROMOSOME SEGREGATION NUCLEUS|MITOCHONDRION|CHROMOSOME Subunit of the condensin complex; essential SMC chromosomal ATPase family member that forms a complex with Smc4p to form the active ATPase; Smc2p/Smc4p complex binds DNA; required for clustering of tRNA genes at the nucleolus mitotic chromosome condensation|mitotic sister chromatid segregation|tRNA gene clustering double-stranded DNA binding|ATPase activity|AT DNA binding|DNA secondary structure binding mitochondrion|nuclear condensin complex
YGL091C YGL091C NBP35 het Verified 0.350971322365809 0.362804931487858 no 360 0.339938088743482 1115 0.005 FT RNA PROCESSING|COFACTOR METABOLISM NUCLEUS Essential iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Cfd1p that is involved in iron-sulfur protein assembly in the cytosol; similar to P-loop NTPases iron-sulfur cluster assembly|tRNA wobble uridine modification 4 iron, 4 sulfur cluster binding|ATPase activity|iron ion binding mitochondrion|nucleus|cytoplasm
YNL181W_p YNL181W YNL181W het Uncharacterized 0.346055731993629 0.364650415547031 no 361 0.341772378845763 1135 0.001 FT OXIDATION-REDUCTION PROCESS ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Putative oxidoreductase; required for cell viability biological_process oxidoreductase activity|oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor nuclear envelope|endoplasmic reticulum
YNL272C YNL272C SEC2 het Verified 0.344773874918033 0.365132187492087 no 362 0.360207000109898 1218 0.005 FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT SITE OF POLARIZED GROWTH Guanyl-nucleotide exchange factor for the small G-protein Sec4p; essential for post-Golgi vesicle transport and for autophagy; associates with the exocyst, via exocyst subunit Sec15p, on secretory vesicles autophagy|exocytosis guanyl-nucleotide exchange factor activity|phosphatidylinositol-4-phosphate binding cytosol|transport vesicle|mating projection tip|cellular bud neck|cellular bud tip
YLR009W YLR009W RLP24 het Verified 0.339523274018382 0.367107783553751 no 363 0.396782340944884 1316 0.002 FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS NUCLEUS Essential protein required for ribosomal large subunit biogenesis; associated with pre-60S ribosomal subunits; stimulates the ATPase activity of Afg2p, which is required for release of Rlp24p from the pre-60S particle; has similarity to Rpl24Ap and Rpl24Bp ribosomal large subunit biogenesis molecular_function nucleolus|preribosome, large subunit precursor
YHR019C YHR019C DED81 het Verified 0.33750523326817 0.367868033883784 no 364 0.354549562768541 1204 0.008 FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA asparaginyl-tRNA aminoacylation asparagine-tRNA ligase activity cytosol
YMR281W YMR281W GPI12 het Verified 0.329708234538456 0.370810215553289 no 365 0.366338468120061 1235 0.002 FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM ER membrane protein involved in the second step of glycosylphosphatidylinositol (GPI) anchor assembly, the de-N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate; functional homolog of human PIG-Lp GPI anchor biosynthetic process N-acetylglucosaminylphosphatidylinositol deacetylase activity integral to membrane|endoplasmic reticulum membrane
YOR151C YOR151C RPB2 het Verified 0.327572680138835 0.371617390624967 no 366 0.376236119212749 1254 0.000 FT TRANSCRIPTION FROM RNA POL II NUCLEUS|MITOCHONDRION RNA POL II, HOLOENZYME RNA polymerase II second largest subunit B150, part of central core; similar to bacterial beta subunit transcription from RNA polymerase II promoter RNA-directed RNA polymerase activity|DNA-directed RNA polymerase activity mitochondrion|DNA-directed RNA polymerase II, core complex
YJR022W YJR022W LSM8 het Verified 0.327447425396896 0.371664750703458 no 367 0.336546977868194 1122 0.001 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNA mRNA splicing, via spliceosome RNA binding U6 snRNP|nucleolus|nucleus|U4/U6 x U5 tri-snRNP complex
YLR117C YLR117C CLF1 het Verified 0.32625695008262 0.372114978274273 no 368 0.348767996358249 1169 0.002 FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING NUCLEUS|CHROMOSOME Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins cis assembly of pre-catalytic spliceosome|DNA replication initiation DNA replication origin binding|chromatin binding|first spliceosomal transesterification activity|second spliceosomal transesterification activity chromatin|U2-type post-mRNA release spliceosomal complex|Prp19 complex|U2-type prespliceosome|U2-type catalytic step 2 spliceosome|U2-type catalytic step 1 spliceosome
YER043C YER043C SAH1 het Verified 0.324454655486688 0.372796923304763 no 369 0.344436903854295 1145 0.002 FT KETONE METABOLISM|AMINO ACID METABOLISM S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor methionine metabolic process|selenocysteine metabolic process adenosylhomocysteinase activity cytoplasm
YGR098C YGR098C ESP1 het Verified 0.322362665463456 0.373588982221484 no 370 0.39704793600675 1316 0.004 FT CELL CYCLE|LIPID METABOLISM|PROTEOLYSIS|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION NUCLEUS|MITOCHONDRION|CYTOSKELETON Separase, a caspase-like cysteine protease; promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin; inhibits protein phosphatase 2A-Cdc55p to promote mitotic exit; inhibited by Pds1p; relative distribution to the nucleus increases upon DNA replication stress regulation of exit from mitosis|regulation of mitotic spindle elongation|negative regulation of protein phosphatase type 2A activity|apoptotic process|mitotic sister chromatid segregation cysteine-type endopeptidase activity mitochondrion|nucleus|cytoplasm|spindle
YDR091C YDR091C RLI1 het Verified 0.318628113921062 0.375004265970546 no 371 0.393592474213428 1344 0.005 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|NUCLEOTIDE METABOLISM NUCLEUS RIBOSOME Essential iron-sulfur protein required for ribosome biogenesis and translation initiation and termination; facilitates binding of a multifactor complex (MFC) of initiation factors to the small ribosomal subunit; predicted ABC family ATPase; forms a complex with Lto1p and Yae1p that may be involved in protection of the ribosome from damage due to reactive oxygen species translational termination|ribosomal subunit export from nucleus|ribosomal large subunit biogenesis|translational initiation ATPase activity|iron ion binding cytosolic ribosome|nucleus|cytoplasm
YJL009W_d YJL009W YJL009W het Dubious 0.313148735137015 0.37708383219541 no 372 0.435027851028135 1452 0.000 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex Unknown Unknown Unknown
YHR070W YHR070W TRM5 het Verified 0.313113508732553 0.377097213142619 no 373 0.374831361787718 1226 0.007 FT RNA PROCESSING NUCLEUS|MITOCHONDRION tRNA(m(1)G37)methyltransferase, methylates a tRNA base adjacent to the anticodon that has a role in prevention of frameshifting; highly conserved across Archaea, Bacteria, and Eukarya tRNA methylation tRNA (guanine) methyltransferase activity nucleus|mitochondrial matrix|cytoplasm
YDL092W YDL092W SRP14 het Verified 0.306115393393904 0.379758393966799 no 374 0.374116731217831 1225 0.001 FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION NUCLEUS Signal recognition particle (SRP) subunit, interacts with the RNA component of SRP to form the Alu domain, which is the region of SRP responsible for arrest of nascent chain elongation during membrane targeting; homolog of mammalian SRP14 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition|protein targeting to ER signal sequence binding signal recognition particle, endoplasmic reticulum targeting
YER127W YER127W LCP5 het Verified 0.304647479481436 0.380317327207231 no 375 0.369058862165969 1251 0.000 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus rRNA modification|rRNA processing RNA binding small nuclear ribonucleoprotein complex|small nucleolar ribonucleoprotein complex
YOR361C YOR361C PRT1 het Verified 0.304238870651922 0.380472956512062 no 376 0.371751582082617 1267 0.001 FT TRANSLATION eIF3b subunit of the core complex of translation initiation factor 3 (eIF3), essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes translational initiation translation initiation factor activity eukaryotic translation initiation factor 3 complex|multi-eIF complex|cytoplasmic stress granule|cytoplasm
YAL033W YAL033W POP5 het Verified 0.303505790219074 0.380752217748979 no 377 0.388039387101561 1305 0.000 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs tRNA processing|intronic box C/D snoRNA processing|mRNA cleavage|rRNA processing ribonuclease MRP activity|ribonuclease P activity nucleolar ribonuclease P complex|ribonuclease MRP complex
YDL148C YDL148C NOP14 het Verified 0.303256813832764 0.380847077492351 no 378 0.39250482492929 1298 0.000 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS|MITOCHONDRION Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal small subunit biogenesis|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA processing snoRNA binding small-subunit processome|mitochondrion|nucleolus|90S preribosome|Noc4p-Nop14p complex
YDR113C YDR113C PDS1 het Verified 0.302919203227929 0.380975718220616 no 379 0.383138948901609 1259 0.003 FT PROTEIN LOCALIZATION|CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION|CHROMOSOME SEGREGATION NUCLEUS|CYTOSKELETON Securin, inhibits anaphase by binding separin Esp1p; blocks cyclin destruction and mitotic exit, essential for meiotic progression and mitotic cell cycle arrest; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation protein localization|recombinational repair|meiosis I|mitotic sister chromatid segregation enzyme binding nucleus|cytoplasm|spindle
YLR409C YLR409C UTP21 het Verified 0.299482824237084 0.382285837638986 no 380 0.397310091301157 1319 0.001 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; synthetic defect with STI1 Hsp90 cochaperone; human homolog linked to glaucoma ribosomal small subunit biogenesis|rRNA processing molecular_function small-subunit processome|nucleolus|nucleus|Pwp2p-containing subcomplex of 90S preribosome|90S preribosome
YOR102W_d YOR102W YOR102W het Dubious 0.298673258256252 0.382594681511567 no 381 0.391105657314303 1283 0.008 Dubious open reading frame, unlikely to encode a functional protein; extensively overlaps essential OST2 gene encoding a subunit of the ER lumen oligosaccharyltransferase complex Unknown Unknown Unknown
YOR206W YOR206W NOC2 het Verified 0.290951291684698 0.385544286114058 no 382 0.399163034797171 1330 0.003 FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS NUCLEUS|MITOCHONDRION Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes, as well as a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors ribosomal subunit export from nucleus|ribosome assembly molecular_function mitochondrion|nucleus|Noc2p-Noc3p complex|Noc1p-Noc2p complex
YDR064W YDR064W RPS13 het Verified 0.288219641608698 0.386589307302006 no 383 0.417824320186363 1404 0.001 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S13 and bacterial S15 cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome|SSU rRNA binding cytosolic small ribosomal subunit|90S preribosome
YIL022W YIL022W TIM44 het Verified 0.287632083203259 0.386814191694062 no 384 0.372636469637461 1227 0.004 FT PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex) protein import into mitochondrial matrix protein binding, bridging|chaperone binding mitochondrion|integral to membrane|presequence translocase-associated import motor
YLR459W YLR459W GAB1 het Verified 0.283953716563925 0.388222925039265 no 385 0.366923928681724 1241 0.001 FT CELL CYCLE|LIPID METABOLISM|CELL DIVISION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM GPI transamidase subunit, involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins; may have a role in recognition of the attachment signal or of the lipid portion of GPI attachment of GPI anchor to protein GPI-anchor transamidase activity integral to membrane|GPI-anchor transamidase complex
YCR013C_d YCR013C YCR013C het Dubious 0.282968851255388 0.388600357321998 no 386 0.390756488160146 1286 0.000 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YCR013C and the overlapping essential gene PGK1 is reduced in a gcr1 null mutant Unknown Unknown Unknown
YNL026W YNL026W SAM50 het Verified 0.282780135203667 0.38867269144555 no 387 0.389972629917535 1298 0.001 FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Essential component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; homologous to bacterial Omp85 protein complex assembly|protein import into mitochondrial outer membrane protein channel activity mitochondrial outer membrane|mitochondrial sorting and assembly machinery complex|mitochondrion|integral to mitochondrial outer membrane
YFL039C YFL039C ACT1 het Verified 0.281566857350927 0.389137828179792 no 388 0.462614641486276 1530 0.001 FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|TRANSCRIPTION FROM RNA POL II|CELL CYCLE|MEMBRANE ORGANIZATION|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|RESPON NUCLEUS|SITE OF POLARIZED GROWTH|CHROMOSOME|CYTOSKELETON HISTONE ACETYLTRANSFERASE Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions ascospore wall assembly|vacuole inheritance|protein secretion|DNA repair|budding cell isotropic bud growth|mitochondrion inheritance|fungal-type cell wall organization|vesicle transport along actin filament|establishment of cell polarity|chronological cell aging|cytokinesis|actin filament reorganization involved in cell cycle|histone acetylation|endocytosis|exocytosis|establishment of mitotic spindle orientation|regulation of transcription from RNA polymerase II promoter|actomyosin contractile ring contraction|cellular response to oxidative stress structural constituent of cytoskeleton cellular bud neck contractile ring|actin filament|histone acetyltransferase complex|Swr1 complex|actin filament bundle|NuA4 histone acetyltransferase complex|Ino80 complex|actin cortical patch
YNL113W YNL113W RPC19 het Verified 0.280399459491213 0.389585525843243 no 389 0.403978650238511 1361 0.008 FT NUCLEUS RNA polymerase subunit AC19, common to RNA polymerases I and III tRNA transcription from RNA polymerase III promoter|transcription from RNA polymerase I promoter DNA-directed RNA polymerase activity DNA-directed RNA polymerase I complex|DNA-directed RNA polymerase III complex
YBR211C YBR211C AME1 het Verified 0.272867049100281 0.392477708323491 no 390 0.370827645127398 1269 0.002 FT PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME|CYTOSKELETON KINETOCHORE Essential kinetochore protein associated with microtubules and SPBs; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p); involved in spindle checkpoint maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-U and fission yeast Mis17; relative distribution to the nucleus increases upon DNA replication stress attachment of spindle microtubules to kinetochore|protein localization to kinetochore molecular_function COMA complex|spindle pole body|kinetochore
YLR457C YLR457C NBP1 het Verified 0.271076055657434 0.393166268572007 no 391 0.387763727659209 1274 0.002 FT CELL CYCLE|CYTOSKELETON ORGANIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON Spindle pole body (SPB) component; required for the insertion of the duplication plaque into the nuclear membrane during SPB duplication; essential for bipolar spindle formation; component of the Mps2p-Bbp1p complex; NBP1 has a paralog, YPR174C, that arose from the whole genome duplication establishment of spindle pole body localization to nuclear envelope|spindle pole body duplication associated with nuclear envelope lipid binding integral to nuclear inner membrane|central plaque of spindle pole body|spindle pole body
YDR224C YDR224C HTB1 het Verified 0.26898039357601 0.393972385245198 no 392 0.385914592432475 1297 0.001 FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB2; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation chromatin assembly or disassembly|negative regulation of transcription from RNA polymerase II promoter|postreplication repair DNA binding replication fork protection complex|nuclear nucleosome
YGL116W YGL116W CDC20 het Verified 0.268025519249225 0.394339837815372 no 393 0.441883067373999 1463 0.002 FF|FT CELL CYCLE|CELL DIVISION|PROTEOLYSIS NUCLEUS UBIQUITIN LIGASE COMPLEX Activator of anaphase-promoting complex/cyclosome (APC/C); APC/C is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; cell-cycle regulated; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress spindle checkpoint|activation of mitotic anaphase-promoting complex activity|meiotic anaphase I|positive regulation of protein catabolic process|activation of anaphase-promoting complex activity involved in meiotic cell cycle|positive regulation of mitotic metaphase/anaphase transition|cyclin catabolic process anaphase-promoting complex binding|ubiquitin-protein ligase activator activity mitotic checkpoint complex|anaphase-promoting complex
YBL030C YBL030C PET9 het Verified 0.26582219371117 0.395188074929629 no 394 0.412011486354201 1349 0.001 FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Major ADP/ATP carrier of the mitochondrial inner membrane; exchanges cytosolic ADP for mitochondrially synthesized ATP; also imports heme and ATP; phosphorylated; required for viability in many lab strains that carry a sal1 mutation; PET9 has a paralog, AAC3, that arose from the whole genome duplication heme transport|transmembrane transport|aerobic respiration|anaerobic respiration|ATP transport|ADP transport|apoptotic process|mitochondrial transport ATP:ADP antiporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YDR023W YDR023W SES1 het Verified 0.265235243792392 0.395414123118617 no 395 0.382570201844483 1252 0.000 FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p seryl-tRNA aminoacylation serine-tRNA ligase activity cytoplasm
YEL055C YEL055C POL5 het Verified 0.264785010428554 0.395587542409662 no 396 0.382874150114433 1239 0.005 FT NUCLEUS DNA Polymerase phi; has sequence similarity to the human MybBP1A and weak sequence similarity to B-type DNA polymerases, not required for chromosomal DNA replication; required for the synthesis of rRNA rRNA transcription|DNA replication DNA-directed DNA polymerase activity nucleolus
YDR365C YDR365C ESF1 het Verified 0.260150210361762 0.397373954291321 no 397 0.372806724987676 1222 0.002 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels rRNA processing RNA binding nucleolus|nucleus
YHR143W-A YHR143W-A RPC10 het Verified 0.258301508289086 0.398087111154303 no 398 0.422977308177365 1388 0.001 FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME RNA polymerase subunit ABC10-alpha, found in RNA pol I, II, and III; relocalizes from nucleolus to cytoplasm upon DNA replication stress transcription from RNA polymerase I promoter|transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter RNA-directed RNA polymerase activity|DNA-directed RNA polymerase activity DNA-directed RNA polymerase III complex|DNA-directed RNA polymerase I complex|DNA-directed RNA polymerase II, core complex
YKL180W YKL180W RPL17A het Verified 0.257668047093333 0.398331554146889 no 399 0.369033328362608 1242 0.002 FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L17A; copurifies with the Dam1 complex (aka DASH complex); homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17A has a paralog, RPL17B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit|cytoplasm
YDR141C YDR141C DOP1 het Verified 0.255708890265128 0.399087814956091 no 400 0.404997620443936 1352 0.000 FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|MITOCHONDRION|GOLGI APPARATUS Golgi-localized, leucine-zipper domain containing protein; involved in endosome to Golgi transport, organization of the ER, establishing cell polarity, and morphogenesis; detected in highly purified mitochondria in high-throughput studies endoplasmic reticulum organization|cell morphogenesis|Golgi to endosome transport molecular_function trans-Golgi network|endosome|mitochondrion|cytoplasm
YIL048W YIL048W NEO1 het Verified 0.255673797587585 0.399101364663136 no 401 0.409076818976363 1360 0.002 FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus retrograde vesicle-mediated transport, Golgi to ER|vacuole organization|endocytosis phospholipid-translocating ATPase activity|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism endosome|COPI-coated vesicle|integral to membrane|Golgi apparatus|Golgi membrane
YML015C YML015C TAF11 het Verified 0.253645013426546 0.399884908928508 no 402 0.407263968310735 1336 0.003 FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors RNA polymerase II transcriptional preinitiation complex assembly|transcription from RNA polymerase II promoter chromatin binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly transcription factor TFIID complex
YER082C YER082C UTP7 het Verified 0.250820778375377 0.400976338082942 no 403 0.406176039230778 1359 0.003 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function small-subunit processome|nucleolus|90S preribosome
YOR372C YOR372C NDD1 het Verified 0.247950176099367 0.402086478430637 no 404 0.414535394041928 1413 0.002 FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE NUCLEUS Transcriptional activator essential for nuclear division; localized to the nucleus; essential component of the mechanism that activates the expression of a set of late-S-phase-specific genes positive regulation of transcription involved in G2/M-phase of mitotic cell cycle transcription coactivator activity nucleus
YJL032W_d YJL032W YJL032W het Dubious 0.245679690478179 0.402965097536467 no 405 0.411092741345091 1353 0.002 Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential BET4 gene encoding the alpha subunit of Type II geranylgeranyltransferase Unknown Unknown Unknown
YKL172W YKL172W EBP2 het Verified 0.243508760838494 0.403805649583427 no 406 0.418613266910929 1378 0.001 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering nuclear division|rRNA processing molecular_function nuclear periphery|nucleolus|preribosome, large subunit precursor
YPR113W YPR113W PIS1 het Verified 0.242489861347087 0.404200305973322 no 407 0.406052063454934 1372 0.000 FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS Phosphatidylinositol synthase, required for biosynthesis of phosphatidylinositol, which is a precursor for polyphosphoinositides, sphingolipids, and glycolipid anchors for some of the plasma membrane proteins phosphatidylinositol biosynthetic process CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity mitochondrial outer membrane|mitochondrion|integral to membrane|Golgi apparatus
YOR362C YOR362C PRE10 het Verified 0.24245971471523 0.404211984334523 no 408 0.425480082684802 1411 0.003 FT PROTEOLYSIS ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION Alpha 7 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process mRNA binding mitochondrion|proteasome core complex, alpha-subunit complex|nucleus|proteasome storage granule|nuclear outer membrane-endoplasmic reticulum membrane network
YCL004W YCL004W PGS1 het Verified 0.239513698961188 0.405353637657832 no 409 0.409221975798963 1366 0.001 FT LIPID METABOLISM MITOCHONDRION Phosphatidylglycerolphosphate synthase, catalyzes the synthesis of phosphatidylglycerolphosphate from CDP-diacylglycerol and sn-glycerol 3-phosphate in the first committed and rate-limiting step of cardiolipin biosynthesis cardiolipin biosynthetic process CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity mitochondrion
YAL043C YAL043C PTA1 het Verified 0.238871249821569 0.405602709800524 no 410 0.399731357167154 1318 0.001 FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII tRNA processing|termination of RNA polymerase II transcription, exosome-dependent|mRNA cleavage|termination of RNA polymerase II transcription, poly(A)-coupled|mRNA polyadenylation RNA binding mRNA cleavage factor complex|mRNA cleavage and polyadenylation specificity factor complex
YEL034W YEL034W HYP2 het Verified 0.237832287388859 0.406005587674936 no 411 0.422982306161516 1382 0.001 FF|FT KETONE METABOLISM|PROTEIN COMPLEX ORG/BIOGENESIS|AMINO ACID METABOLISM|TRANSLATION MITOCHONDRION RIBOSOME Translation elongation factor eIF-5A; may function in translation initiation; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has a paralog, ANB1, that arose from the whole genome duplication positive regulation of translational initiation|translational frameshifting|positive regulation of translational termination|positive regulation of translational elongation ribosome binding|RNA binding|translation elongation factor activity|translation initiation factor activity mitochondrion|cytosolic ribosome|cytoplasm
YDL153C YDL153C SAS10 het Verified 0.237305328377483 0.406209964353522 no 412 0.403355399644971 1348 0.002 FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|GENE SILENCING NUCLEUS Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function small-subunit processome|nucleolus|nucleus
YOL135C YOL135C MED7 het Verified 0.23505085160166 0.407084632381952 no 413 0.403265500467536 1338 0.002 FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter molecular_function core mediator complex
YJR068W YJR068W RFC2 het Verified 0.233514149293746 0.40768109183814 no 414 0.388207533341051 1275 0.003 FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon mismatch repair|sister chromatid cohesion|cell cycle checkpoint|leading strand elongation DNA clamp loader activity|purine nucleotide binding Elg1 RFC-like complex|DNA replication factor C complex|Rad17 RFC-like complex|Ctf18 RFC-like complex
YFR003C YFR003C YPI1 het Verified 0.230244260445864 0.408950985359205 no 415 0.402316475353968 1316 0.000 FT CELL CYCLE|LIPID METABOLISM|ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Regulatory subunit of the type I protein phosphatase (PP1) Glc7p; Glc7p participates in the regulation of a variety of metabolic processes including mitosis and glycogen metabolism; in vitro evidence suggests Ypi1p is an inhibitor of Glc7p while in vivo evidence suggests it is an activator; overproduction causes decreased cellular content of glycogen; partial depletion causes lithium sensitivity, while overproduction confers lithium-tolerance negative regulation of phosphoprotein phosphatase activity|glycogen metabolic process|cellular ion homeostasis|Unknown|positive regulation of phosphoprotein phosphatase activity|negative regulation of protein dephosphorylation|mitotic cell cycle spindle assembly checkpoint protein serine/threonine phosphatase inhibitor activity|protein phosphatase type 1 activator activity nucleus
YOR262W YOR262W GPN2 het Verified 0.230135608303678 0.408993197977425 no 416 0.407735395686242 1351 0.001 FT PROTEIN LOCALIZATION|CELL CYCLE|CHROMOSOME SEGREGATION Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn3p; highly conserved across species and homologous to human gene GPN2/ATPBD1B; required for establishment of sister chromatid cohesion establishment of mitotic sister chromatid cohesion molecular_function cytoplasm
YNL313C YNL313C EMW1 het Verified 0.229183572877765 0.409363119881554 no 417 0.401523330895592 1324 0.001 FT CELL WALL ORG/BIOGENESIS NUCLEUS Essential conserved protein with a role in cell wall integrity; contains six TPR (tetratricopeptide repeat) domains clustered in the C-terminal region; conditional mutant is suppressed by overexpression of GFA1; protein abundance increases in response to DNA replication stress fungal-type cell wall organization molecular_function nucleus|cytoplasm
YHR186C YHR186C KOG1 het Verified 0.228371065088901 0.409678890926711 no 418 0.413314864886751 1353 0.001 FT SIGNALING|RESPONSE TO NUTRIENT LEVELS MITOCHONDRION|PLASMA MEMBRANE Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors TOR signaling cascade|regulation of cell growth|cellular response to starvation ubiquitin binding TORC1 complex|fungal-type vacuole membrane|mitochondrion|plasma membrane
YDR267C YDR267C CIA1 het Verified 0.227662677361404 0.409954244827343 no 419 0.403858192996172 1345 0.001 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|COFACTOR METABOLISM NUCLEUS Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia2p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; contains WD40 repeats; ortholog of human Ciao1 protein iron-sulfur cluster assembly|ribosomal large subunit export from nucleus|tRNA wobble uridine modification molecular_function cytosol|nucleus|cytoplasm
YDR196C YDR196C CAB5 het Verified 0.227159175418985 0.41014998559348 no 420 0.397721424876047 1313 0.001 FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION Probable dephospho-CoA kinase (DPCK) that catalyzes the last step in coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaE (encoding DPCK); detected in purified mitochondria in high-throughput studies coenzyme A biosynthetic process dephospho-CoA kinase activity nuclear envelope|mitochondrion|endoplasmic reticulum
YPR112C YPR112C MRD1 het Verified 0.226256808825877 0.410500844454686 no 421 0.414580998927748 1363 0.008 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Essential conserved small ribosomal subunit (40s) synthesis factor; component of the 90S preribosome; required for production of 18S rRNA and small ribosomal subunit; contains five consensus RNA-binding domains and binds to the pre-rRNA at two sites within the 18S region endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|small-subunit processome assembly|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function nucleolus|90S preribosome
YLR340W YLR340W RPP0 het Verified 0.217834555209689 0.413779009922376 no 422 0.428470009089579 1413 0.000 FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Conserved ribosomal protein P0 of the ribosomal stalk; involved in interaction between translational elongation factors and the ribosome; phosphorylated on serine 302; homologous to mammalian ribosomal protein LP0 and bacterial L10 translational elongation|cytoplasmic translation|ribosomal large subunit assembly structural constituent of ribosome|LSU rRNA binding cytosolic large ribosomal subunit|preribosome, large subunit precursor|90S preribosome|cytoplasm
YPL160W YPL160W CDC60 het Verified 0.217726341014697 0.413821169414363 no 423 0.402815889434676 1322 0.000 FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA leucyl-tRNA aminoacylation|DNA replication initiation leucine-tRNA ligase activity cytoplasm
YMR308C YMR308C PSE1 het Verified 0.217480534191652 0.413916937720024 no 424 0.371321900423217 1245 0.003 FT PROTEIN LOCALIZATION|CELL CYCLE|RNA LOCALIZATION NUCLEUS Karyopherin/importin that interacts with the nuclear pore complex; acts as the nuclear import receptor for specific proteins, including Pdr1p, Yap1p, Ste12p, and Aft1p mRNA export from nucleus|regulation of protein desumoylation|protein import into nucleus|regulation of mitosis protein transporter activity|nuclear localization sequence binding integral to membrane|nucleus|cytoplasm
YBR088C YBR088C POL30 het Verified 0.214472502264968 0.415089304036587 no 425 0.405509634950521 1335 0.001 FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|GENE SILENCING NUCLEUS|CHROMOSOME Proliferating cell nuclear antigen (PCNA), functions as the sliding clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair lagging strand elongation|postreplication repair|base-excision repair|nucleotide-excision repair|mismatch repair|meiotic mismatch repair|leading strand elongation|chromatin silencing at telomere|mitotic sister chromatid cohesion|chromatin silencing at silent mating-type cassette DNA polymerase processivity factor activity PCNA complex|nucleus|replication fork
YPR094W YPR094W RDS3 het Verified 0.213516985817092 0.415461870904425 no 426 0.428434183764886 1412 0.002 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING NUCLEUS Component of the SF3b subcomplex of the U2 snRNP, zinc cluster protein involved in pre-mRNA splicing and cycloheximide resistance spliceosomal complex assembly|response to xenobiotic stimulus|mRNA splicing, via spliceosome molecular_function U2 snRNP
YML105C YML105C SEC65 het Verified 0.211167283632347 0.41637836949115 no 427 0.415153760268091 1375 0.005 FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS Subunit of the signal recognition particle (SRP), involved in protein targeting to the ER; interacts with Srp54p; homolog of mammalian SRP19 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition|protein targeting to ER 7S RNA binding signal recognition particle, endoplasmic reticulum targeting
YJL173C YJL173C RFA3 het Verified 0.206190373790289 0.41832110344912 no 428 0.41718646673717 1385 0.001 FT PROTEIN LOCALIZATION|CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein complex involved in DNA replication, repair, and recombination; protein abundance increases in response to DNA replication stress establishment of protein localization|telomere maintenance via telomerase|telomere maintenance via recombination|nucleotide-excision repair|DNA repair|mitotic recombination|heteroduplex formation|DNA unwinding involved in replication|reciprocal meiotic recombination|double-strand break repair via homologous recombination|DNA replication|protein ubiquitination double-stranded DNA binding|sequence-specific DNA binding condensed nuclear chromosome|chromosome, telomeric region|DNA replication factor A complex
YDL111C YDL111C RRP42 het Verified 0.204824160975336 0.418854754731336 no 429 0.428036339553748 1427 0.004 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7) nuclear polyadenylation-dependent tRNA catabolic process|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nonfunctional rRNA decay|nuclear polyadenylation-dependent mRNA catabolic process|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|rRNA catabolic process|polyadenylation-dependent snoRNA 3'-end processing|nuclear-transcribed mRNA catabolic process, non-stop decay|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ncRNA 3'-end processing molecular_function nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)
YLR195C YLR195C NMT1 het Verified 0.200987131612471 0.420354318120348 no 430 0.414915095516961 1400 0.000 N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction N-terminal peptidyl-glycine N-myristoylation|replicative cell aging glycylpeptide N-tetradecanoyltransferase activity cytosol
YGL120C YGL120C PRP43 het Verified 0.200530518715223 0.420532846108534 no 431 0.420692269407258 1367 0.003 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS|MITOCHONDRION RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|spliceosomal complex disassembly|ribosomal large subunit biogenesis|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of SSU-rRNA|rRNA processing ATP-dependent RNA helicase activity mitochondrion|post-mRNA release spliceosomal complex|90S preribosome
YGR048W YGR048W UFD1 het Verified 0.197788899488874 0.421605115764264 no 432 0.433516660845192 1422 0.002 FT PROTEOLYSIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; polyubiquitin binding protein that assists in the dislocation of misfolded, ERAD substrates that are subsequently delivered to the proteasome for degradation; involved in regulated destruction of ER membrane proteins such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); involved in mobilizing membrane bound transaction factors by regulated Ub/proteasome-dependent processing (RUP) retrograde protein transport, ER to cytosol|proteasomal ubiquitin-dependent protein catabolic process|ER-associated protein catabolic process|ER-associated misfolded protein catabolic process|Unknown|cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process ubiquitin binding|polyubiquitin binding nucleus|Cdc48p-Npl4p-Ufd1p AAA ATPase complex
YPR162C YPR162C ORC4 het Verified 0.195619789789064 0.422453884764278 no 433 0.4288710027634 1430 0.005 FT GENE SILENCING NUCLEUS|CHROMOSOME Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing pre-replicative complex assembly|DNA replication initiation|chromatin silencing at silent mating-type cassette DNA replication origin binding DNA replication preinitiation complex|pre-replicative complex|nuclear origin of replication recognition complex
YMR043W YMR043W MCM1 het Verified 0.190672070720718 0.424391260775078 no 434 0.417078129562146 1407 0.004 FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CELL CYCLE|AMINO ACID METABOLISM NUCLEUS|CHROMOSOME Transcription factor involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexes regulation of mating type switching|positive regulation of transcription involved in G2/M-phase of mitotic cell cycle|DNA replication initiation|negative regulation of mating-type specific transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|Unknown|positive regulation of mating-type specific transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter DNA replication origin binding|RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding, bending|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity|RNA polymerase II repressing transcription factor binding nuclear chromatin
YML049C YML049C RSE1 het Verified 0.186528516403297 0.426015159197133 no 435 0.416455522149056 1403 0.001 FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING NUCLEUS Protein involved in pre-mRNA splicing; component of the pre-spliceosome; associates with U2 snRNA; involved in ER to Golgi transport spliceosomal complex assembly|mRNA splicing, via spliceosome U2 snRNA binding U2 snRNP|U2-type prespliceosome
YDR353W YDR353W TRR1 het Verified 0.185239414636019 0.426520627800267 no 436 0.424935818459694 1422 0.001 FT OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS Cytoplasmic thioredoxin reductase; key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress; protein abundance increases in response to DNA replication stress; TRR1 has a paralog, TRR2, that arose from the whole genome duplication cellular response to oxidative stress|cell redox homeostasis ferrous iron binding|thioredoxin-disulfide reductase activity cytosol
YLR305C YLR305C STT4 het Verified 0.184628147837543 0.426760353349137 no 437 0.421737483620026 1385 0.000 FT LIPID METABOLISM|SIGNALING MITOCHONDRION|PLASMA MEMBRANE Phosphatidylinositol-4-kinase that functions in the Pkc1p protein kinase pathway; required for normal vacuole morphology, cell wall integrity, and actin cytoskeleton organization phosphatidylinositol phosphorylation 1-phosphatidylinositol 4-kinase activity mitochondrion|plasma membrane
YKR038C YKR038C KAE1 het Verified 0.184359470240875 0.426865731426151 no 438 0.414504734845261 1361 0.001 FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|PROTEOLYSIS NUCLEUS|CHROMOSOME Highly conserved ATPase of HSP70/DnaK family; component of the EKC/KEOPS complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription chromosome organization|threonylcarbamoyladenosine metabolic process|telomere maintenance|positive regulation of transcription from RNA polymerase II promoter chromatin DNA binding nuclear chromatin|EKC/KEOPS complex|nucleus|cytoplasm
YJL090C YJL090C DPB11 het Verified 0.183273273157385 0.427291802064645 no 439 0.438548657048694 1443 0.004 FT CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION NUCLEUS|CHROMOSOME DNA replication initiation protein; loads DNA pol epsilon onto pre-replication complexes at origins; checkpoint sensor recruited to stalled replication forks by the checkpoint clamp complex where it activates Mec1p; ortholog of human TopBP1; forms nuclear foci upon DNA replication stress lagging strand elongation|recombinational repair|nucleotide-excision repair|DNA replication initiation|mismatch repair|positive regulation of protein phosphorylation|mating type switching|DNA replication checkpoint|double-strand break repair via break-induced replication|mitotic cell cycle G2/M transition DNA damage checkpoint|leading strand elongation protein kinase activator activity|protein binding DNA replication preinitiation complex|replication fork|epsilon DNA polymerase complex
YPR035W YPR035W GLN1 het Verified 0.179299452541412 0.428851288347975 no 440 0.427034673984917 1411 0.001 FT KETONE METABOLISM|AMINO ACID METABOLISM Glutamine synthetase (GS); synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress nitrogen compound metabolic process|glutamine biosynthetic process glutamate-ammonia ligase activity cytoplasm
YKR022C YKR022C NTR2 het Verified 0.17821243616122 0.42927807170825 no 441 0.427872348818447 1396 0.000 FT RNA PROCESSING NUCLEUS|ENDOPLASMIC RETICULUM Essential protein that forms a dimer with Ntr1p; also forms a trimer, with Ntr2p and the DExD/H-box RNA helicase Prp43p, that is involved in spliceosome disassembly spliceosomal complex disassembly|mRNA splicing, via spliceosome molecular_function endoplasmic reticulum|U2-type post-mRNA release spliceosomal complex|nucleus|spliceosomal complex|cytoplasm
YLL008W YLL008W DRS1 het Verified 0.177913583778903 0.429395421364414 no 442 0.429223843460088 1407 0.001 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Nucleolar DEAD-box protein required for ribosome assembly and function, including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles ribosomal large subunit assembly|rRNA processing ATP-dependent RNA helicase activity nucleolus|preribosome, large subunit precursor
YBL050W YBL050W SEC17 het Verified 0.177085091409217 0.429720776092683 no 443 0.420632642146427 1369 0.000 FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION Peripheral membrane protein required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, and autophagy; stimulates the ATPase activity of Sec18p; has similarity to mammalian alpha-SNAP autophagy|SNARE complex disassembly|vesicle fusion with Golgi apparatus|vacuole fusion, non-autophagic ATPase activator activity|soluble NSF attachment protein activity SNARE complex|cytosol|extrinsic to membrane
YJR065C YJR065C ARP3 het Verified 0.176627546360812 0.429900477697791 no 444 0.449791181994115 1502 0.001 FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION CYTOSKELETON Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity mitochondrion inheritance|Arp2/3 complex-mediated actin nucleation|actin filament organization ATP binding Arp2/3 protein complex|plasma membrane
YLR060W YLR060W FRS1 het Verified 0.175937969738416 0.430171337529456 no 445 0.430849829717715 1435 0.004 FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs2p to generate active enzyme; able to hydrolyze mis-aminoacylated tRNA-Phe, which could contribute to translational quality control phenylalanyl-tRNA aminoacylation phenylalanine-tRNA ligase activity phenylalanine-tRNA ligase complex|cytoplasm
YOR046C YOR046C DBP5 het Verified 0.172207761347138 0.431637098181897 no 446 0.420220214840594 1376 0.000 FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|SITE OF POLARIZED GROWTH NUCLEAR PORE Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family; involved in mRNA export from the nucleus; involved in translation termination; ATP/ADP cycling is regulated by Gle1p and Nup159p translational termination|mRNA export from nucleus RNA helicase activity|inositol hexakisphosphate binding|RNA-dependent ATPase activity nuclear pore cytoplasmic filaments|nucleus|polysome|nuclear pore|cellular bud tip|cytoplasm
YOR122C YOR122C PFY1 het Verified 0.172137903976879 0.43166455721861 no 447 0.431269224430523 1440 0.000 FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION PLASMA MEMBRANE|CYTOSKELETON Profilin; binds actin, phosphatidylinositol 4,5-bisphosphate, and polyproline regions; involved in cytoskeleton organization; required for normal timing of actin polymerization in response to thermal stress; protein abundance increases in response to DNA replication stress positive regulation of formin-nucleated actin cable assembly|sequestering of actin monomers|intracellular transport actin monomer binding|phosphatidylinositol-4,5-bisphosphate binding|proline-rich region binding cytosol|extrinsic to plasma membrane
YGR065C YGR065C VHT1 het Verified 0.172034170699894 0.431705332564227 no 448 0.426335440072304 1400 0.003 FT PLASMA MEMBRANE High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin biotin transport biotin transporter activity integral to membrane|plasma membrane
YLL003W YLL003W SFI1 het Verified 0.169510326649047 0.432697625204356 no 449 0.427149945365498 1415 0.000 FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION CYTOSKELETON Centrin (Cdc31p)-binding protein required for spindle pole body (SPB) duplication, localizes to the half-bridge of the SPB, required for progression through G(2)-M transition, has similarity to Xenopus laevis XCAP-C G2/M transition of mitotic cell cycle|spindle assembly|spindle pole body duplication associated with nuclear envelope molecular_function half bridge of spindle pole body
YPL083C YPL083C SEN54 het Verified 0.169405133948594 0.432738992781603 no 450 0.44418071596429 1495 0.000 FT RNA PROCESSING ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p tRNA-type intron splice site recognition and cleavage tRNA-intron endonuclease activity mitochondrial outer membrane|mitochondrion|tRNA-intron endonuclease complex
YMR208W YMR208W ERG12 het Verified 0.169176526167527 0.432828896523259 no 451 0.443478146983703 1460 0.000 FF|FT LIPID METABOLISM|COFACTOR METABOLISM Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate ergosterol biosynthetic process|isopentenyl diphosphate biosynthetic process, mevalonate pathway|farnesyl diphosphate biosynthetic process, mevalonate pathway mevalonate kinase activity cytosol
YHR088W YHR088W RPF1 het Verified 0.168912657434333 0.432932671532575 no 452 0.43400299870845 1451 0.003 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Nucleolar protein involved in the assembly and export of the large ribosomal subunit; constituent of 66S pre-ribosomal particles; contains a sigma(70)-like motif, which is thought to bind RNA maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal large subunit assembly|ribosomal large subunit export from nucleus|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) rRNA primary transcript binding nucleolus|preribosome, large subunit precursor
YDL143W YDL143W CCT4 het Verified 0.166133058235846 0.434026119464543 no 453 0.460730564699831 1549 0.002 FF Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo protein folding unfolded protein binding chaperonin-containing T-complex
YDL141W YDL141W BPL1 het Verified 0.164594367420023 0.434631632448628 no 454 0.426518485288637 1391 0.002 FT NUCLEUS Biotin:apoprotein ligase, covalently modifies proteins with the addition of biotin, required for acetyl-CoA carboxylase (Acc1p) holoenzyme formation protein biotinylation biotin-[pyruvate-carboxylase] ligase activity|biotin-[acetyl-CoA-carboxylase] ligase activity nucleus|cytoplasm
YHR085W YHR085W IPI1 het Verified 0.162138421879307 0.43559842509996 no 455 0.401393243938387 1332 0.003 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and possibly pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; IPI1 is an essential gene ribosomal large subunit assembly|rRNA processing molecular_function nucleoplasm|nucleus
YOL094C YOL094C RFC4 het Verified 0.158907656931594 0.436870813997329 no 456 0.431021748572564 1427 0.001 FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon mismatch repair|sister chromatid cohesion|leading strand elongation DNA clamp loader activity Elg1 RFC-like complex|Rad17 RFC-like complex|DNA replication factor C complex|Ctf18 RFC-like complex
YKL111C_d YKL111C YKL111C het Dubious 0.158281682137774 0.437117420860394 no 457 0.435512537042229 1424 0.001 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified essential gene ABF1 Unknown Unknown Unknown
YDR434W YDR434W GPI17 het Verified 0.157173537434557 0.437554041569126 no 458 0.428160094941594 1398 0.002 FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-S homolog attachment of GPI anchor to protein GPI-anchor transamidase activity integral to membrane|endoplasmic reticulum|GPI-anchor transamidase complex
YKR062W YKR062W TFA2 het Verified 0.155446648602134 0.438234605407531 no 459 0.444782153439284 1495 0.001 FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME TFIIE small subunit, involved in RNA polymerase II transcription initiation transcription from RNA polymerase II promoter single-stranded DNA binding|RNA polymerase II core binding|TFIIH-class transcription factor binding transcription factor TFIIE complex
YGR099W YGR099W TEL2 het Verified 0.154562233530746 0.438583222699822 no 460 0.4552605756165 1516 0.002 FT PROTEIN LOCALIZATION NUCLEUS|CHROMOSOME Subunit of the ASTRA complex, involved in chromatin remodeling; subunit of the telomere cap complex DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect; involved in the stability or biogenesis of PIKKs such as TORC1 protein localization to chromosome|telomere maintenance via telomerase|telomere maintenance telomeric DNA binding ASTRA complex|nuclear telomere cap complex
YDR473C YDR473C PRP3 het Verified 0.152535994290883 0.43938210162172 no 461 0.450097981322299 1480 0.000 FT RNA PROCESSING NUCLEUS Splicing factor, component of the U4/U6-U5 snRNP complex mRNA splicing, via spliceosome molecular_function U4/U6 x U5 tri-snRNP complex
YEL002C YEL002C WBP1 het Verified 0.152524874539669 0.439386486455049 no 462 0.441786884086609 1469 0.001 FT CELL CYCLE|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Beta subunit of the oligosaccharyl transferase (OST) glycoprotein complex; required for N-linked glycosylation of proteins in the endoplasmic reticulum cell cycle|protein N-linked glycosylation dolichyl-diphosphooligosaccharide-protein glycotransferase activity nuclear envelope|oligosaccharyltransferase complex|endoplasmic reticulum
YBR136W YBR136W MEC1 het Verified 0.151640842885928 0.439735108966042 no 463 0.44884254443618 1477 0.000 FT CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION NUCLEUS|MITOCHONDRION Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; regulates P-body formation induced by replication stress; monitors and participates in meiotic recombination; associates with shortened, dysfunctional telomeres histone phosphorylation|telomere maintenance via recombination|telomere maintenance|nucleobase-containing compound metabolic process|reciprocal meiotic recombination|DNA recombination|DNA damage checkpoint|DNA replication|DNA damage induced protein phosphorylation protein kinase activity mitochondrion|nucleus
YKL152C YKL152C GPM1 het Verified 0.151321993838005 0.439860860239947 no 464 0.43081731431874 1402 0.003 FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis gluconeogenesis|glycolysis phosphoglycerate mutase activity cytosol|mitochondrion
YPL076W YPL076W GPI2 het Verified 0.148190774656503 0.441096106095625 no 465 0.453292740113664 1526 0.001 FT LIPID METABOLISM ENDOPLASMIC RETICULUM Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-C protein GPI anchor biosynthetic process phosphatidylinositol N-acetylglucosaminyltransferase activity glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|integral to membrane|endoplasmic reticulum
YGL073W YGL073W HSF1 het Verified 0.146902638787082 0.441604434535379 no 466 0.425557508453229 1401 0.008 FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|SIGNALING|CYTOSKELETON ORGANIZATION NUCLEUS|MITOCHONDRION Trimeric heat shock transcription factor, activates multiple genes in response to stresses that include hyperthermia; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; posttranslationally regulated spindle pole body duplication|negative regulation of TOR signaling cascade|response to heat|regulation of transcription from RNA polymerase II promoter|response to stress sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity mitochondrion|nucleus
YGL150C YGL150C INO80 het Verified 0.138438965131661 0.444946751877913 no 467 0.460374692232524 1523 0.000 FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING NUCLEUS|CHROMOSOME ATPase and nucleosome spacing factor, subunit of complex containing actin and actin-related proteins that has chromatin remodeling activity and 3' to 5' DNA helicase activity in vitro; has a role in modulating stress gene transcription nucleosome positioning|histone exchange|transcription from RNA polymerase II promoter|DNA repair|nucleosome mobilization|chromatin remodeling|chromatin silencing at telomere|regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter ATPase activity|ATP-dependent 3'-5' DNA helicase activity Ino80 complex
YBL092W YBL092W RPL32 het Verified 0.138129569159227 0.445069008477876 no 468 0.450766025894271 1488 0.006 FF|FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L32; overexpression disrupts telomeric silencing; homologous to mammalian ribosomal protein L32, no bacterial homolog cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YHR118C YHR118C ORC6 het Verified 0.132549859970531 0.447274694170981 no 469 0.428537077706687 1407 0.003 FT GENE SILENCING NUCLEUS|CHROMOSOME Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; phosphorylated by Cdc28p DNA replication initiation|pre-replicative complex assembly|chromatin silencing at silent mating-type cassette DNA replication origin binding pre-replicative complex|DNA replication preinitiation complex|nuclear origin of replication recognition complex
YDR052C YDR052C DBF4 het Verified 0.129292578246091 0.448563071922703 no 470 0.456935266952922 1502 0.001 FT CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION|CHROMOSOME SEGREGATION Regulatory subunit of Cdc7p-Dbf4p kinase complex; required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated; relative distribution to the nucleus increases upon DNA replication stress negative regulation of exit from mitosis|DNA replication initiation|positive regulation of protein kinase activity DNA replication origin binding|protein serine/threonine kinase activator activity Dbf4-dependent protein kinase complex
YNR011C YNR011C PRP2 het Verified 0.127992314599391 0.4490775275391 no 471 0.458011661210902 1530 0.000 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING NUCLEUS RNA-dependent ATPase in the DEAH-box family, required for activation of the spliceosome before the first transesterification step in RNA splicing; orthologous to human protein DHX16 generation of catalytic spliceosome for first transesterification step RNA-dependent ATPase activity U2-type catalytic step 1 spliceosome
YDL105W YDL105W NSE4 het Verified 0.127598374495047 0.449233408791325 no 472 0.464677603859974 1554 0.000 FT RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair DNA repair molecular_function Smc5-Smc6 complex|nucleus
YOL066C YOL066C RIB2 het Verified 0.127344412827185 0.44933390503272 no 473 0.460959584842446 1521 0.007 FT RNA PROCESSING Bifunctional enzyme with DRAP deaminase and tRNA:pseudouridine synthase activity; the deaminase catalyzes the third step in riboflavin biosynthesis and the synthase catalyzes formation of pseudouridine at position 32 in cytoplasmic tRNAs riboflavin biosynthetic process|tRNA pseudouridine synthesis pseudouridine synthase activity|2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase activity cytoplasm
YDR201W YDR201W SPC19 het Verified 0.119903889593315 0.452279641629114 no 474 0.449721517031906 1471 0.002 FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME|CYTOSKELETON KINETOCHORE Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body microtubule nucleation|mitotic spindle organization in nucleus|regulation of microtubule polymerization or depolymerization microtubule binding|structural constituent of cytoskeleton spindle microtubule|condensed nuclear chromosome kinetochore|DASH complex|spindle pole body|spindle
YDR454C YDR454C GUK1 het Verified 0.118219441718392 0.452946892857036 no 475 0.446726062901051 1485 0.002 FT NUCLEOTIDE METABOLISM NUCLEUS Guanylate kinase, converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins GMP metabolic process guanylate kinase activity nucleus|cytoplasm
YIL142W YIL142W CCT2 het Verified 0.116393476077143 0.453670352794795 no 476 0.464832961461583 1535 0.003 Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo protein folding unfolded protein binding chaperonin-containing T-complex|cytoplasm
YMR268C YMR268C PRP24 het Verified 0.112958531707526 0.455031715815666 no 477 0.457719885301727 1515 0.000 FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING NUCLEUS Splicing factor that reanneals U4 and U6 snRNPs during spliceosome recycling assembly of spliceosomal tri-snRNP|spliceosomal complex assembly U6 snRNA binding|snRNA binding U6 snRNP
YNL151C YNL151C RPC31 het Verified 0.112554671567777 0.455191811724164 no 478 0.453814087648221 1494 0.000 FT NUCLEUS RNA polymerase III subunit C31 transcription initiation from RNA polymerase III promoter|tRNA transcription from RNA polymerase III promoter DNA-directed RNA polymerase activity DNA-directed RNA polymerase III complex
YLR336C YLR336C SGD1 het Verified 0.112251384721031 0.455312043733738 no 479 0.451862357962227 1506 0.001 FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS NUCLEUS Essential nuclear protein, required for biogenesis of the small ribosomal subunit; has a possible role in the osmoregulatory glycerol response; putative homolog of human NOM1 which is implicated in acute myeloid leukemia ribosomal small subunit biogenesis|hyperosmotic response molecular_function nucleolus|nucleus|FAl1-SGD1 complex
YDR166C YDR166C SEC5 het Verified 0.111404438288391 0.455647820363125 no 480 0.459659133068667 1527 0.002 FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION SITE OF POLARIZED GROWTH Essential 107kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in assembly of the exocyst complex; required with Sec3p for ER inheritance where it promotes anchoring of the cortical ER at the bud tip Golgi to plasma membrane transport|endoplasmic reticulum inheritance|exocytosis|exocyst assembly|vesicle fusion|vesicle docking involved in exocytosis molecular_function incipient cellular bud site|mating projection tip|cellular bud neck|exocyst|cellular bud tip
YDR328C YDR328C SKP1 het Verified 0.10953147512452 0.456390479202603 no 481 0.458596519776657 1500 0.000 FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|ION HOMEOSTASIS|CELL DIVISION|PROTEOLYSIS|CYTOSKELETON ORGANIZATION|ION HOMEOSTASIS NUCLEUS|CHROMOSOME UBIQUITIN LIGASE COMPLEX|KINETOCHORE Evolutionarily conserved kinetochore protein; part of multiple protein complexes, including the SCF ubiquitin ligase complex, the CBF3 complex that binds centromeric DNA, and the RAVE complex that regulates assembly of the V-ATPase; protein abundance increases in response to DNA replication stress kinetochore assembly|protein complex assembly|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of protein complex assembly|G1/S transition of mitotic cell cycle|septin ring assembly|regulation of exit from mitosis|G2/M transition of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|protein neddylation|vacuolar acidification|cytokinesis ubiquitin-protein ligase activity|DNA replication origin binding|protein binding RAVE complex|SCF ubiquitin ligase complex|nucleus|CBF3 complex|kinetochore|cytoplasm
YDR167W YDR167W TAF10 het Verified 0.109128730316219 0.456550193736054 no 482 0.462812869277265 1545 0.001 FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS RNA POL II, HOLOENZYME|HISTONE ACETYLTRANSFERASE Subunit (145 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification histone acetylation|RNA polymerase II transcriptional preinitiation complex assembly|chromatin modification|transcription from RNA polymerase II promoter chromatin binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly|protein complex scaffold SLIK (SAGA-like) complex|SAGA complex|transcription factor TFIID complex
YJL033W YJL033W HCA4 het Verified 0.108531457317883 0.456787064276717 no 483 0.43143172773486 1407 0.003 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis rRNA processing RNA-dependent ATPase activity|ATP-dependent RNA helicase activity nucleolus
YDL196W_d YDL196W YDL196W het Dubious 0.105161887067564 0.458123676348155 no 484 0.477555026214186 1587 0.005 FF Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31 Unknown Unknown Unknown
YGL075C YGL075C MPS2 het Verified 0.100332925571294 0.460040009271642 no 485 0.468963685248272 1576 0.001 FT CELL CYCLE|CYTOSKELETON ORGANIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON Essential membrane protein localized at the nuclear envelope and spindle pole body (SPB), required for insertion of the newly duplicated SPB into the nuclear envelope; potentially phosphorylated by Cdc28p mitotic anaphase|spindle pole body duplication associated with nuclear envelope structural constituent of cytoskeleton nuclear envelope|spindle pole body
YPL117C YPL117C IDI1 het Verified 0.0990838379643823 0.460535852185705 no 486 0.459146782937996 1532 0.003 FT LIPID METABOLISM NUCLEUS Isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IPP isomerase), catalyzes an essential activation step in the isoprenoid biosynthetic pathway; required for viability farnesyl diphosphate biosynthetic process isopentenyl-diphosphate delta-isomerase activity nucleus|cytoplasm
YHR196W YHR196W UTP9 het Verified 0.0965105860015485 0.461557533380253 no 487 0.484747820924125 1614 0.001 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS|CHROMOSOME Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA positive regulation of transcription from RNA polymerase I promoter|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) snoRNA binding small-subunit processome|rDNA heterochromatin|nucleolus|t-UTP complex|nucleus|90S preribosome
YHR024C YHR024C MAS2 het Verified 0.0953070381578843 0.462035476231404 no 488 0.475493550473647 1579 0.002 FT PROTEIN LOCALIZATION|PROTEOLYSIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Larger subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins protein processing involved in protein targeting to mitochondrion metalloendopeptidase activity mitochondrion|mitochondrial processing peptidase complex
YPL126W YPL126W NAN1 het Verified 0.0935531077825911 0.462732080369093 no 489 0.449979365762086 1496 0.001 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS|CHROMOSOME U3 snoRNP protein, component of the small (ribosomal) subunit (SSU) processosome containing U3 snoRNA; required for the biogenesis of18S rRNA positive regulation of transcription from RNA polymerase I promoter|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) snoRNA binding small-subunit processome|rDNA heterochromatin|nucleolus|t-UTP complex|RENT complex|90S preribosome
YHR074W YHR074W QNS1 het Verified 0.0929572347504923 0.462968767891332 no 490 0.463408324373383 1519 0.000 FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM NUCLEUS Glutamine-dependent NAD(+) synthetase, essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide NAD biosynthetic process NAD+ synthase (glutamine-hydrolyzing) activity|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides nucleus|cytoplasm
YIL061C YIL061C SNP1 het Verified 0.0929239670578891 0.462981982583096 no 491 0.468967668258438 1540 0.001 FT RNA PROCESSING NUCLEUS Component of U1 snRNP required for mRNA splicing via spliceosome; substrate of the arginine methyltransferase Hmt1p; may interact with poly(A) polymerase to regulate polyadenylation; homolog of human U1 70K protein; protein abundance increases in response to DNA replication stress mRNA splicing, via spliceosome mRNA binding|U1 snRNA binding commitment complex|U1 snRNP|U2-type prespliceosome
YOL077C YOL077C BRX1 het Verified 0.0923740322772439 0.463200435219997 no 492 0.447828683635588 1483 0.001 FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS NUCLEUS Nucleolar protein, constituent of 66S pre-ribosomal particles; depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits; possesses a sigma(70)-like RNA-binding motif ribosomal large subunit assembly 5S rRNA binding|rRNA primary transcript binding nucleolus|preribosome, large subunit precursor
YGL103W YGL103W RPL28 het Verified 0.091524846460406 0.463537782233831 no 493 0.472561596103833 1567 0.003 FT TRANSLATION NUCLEUS RIBOSOME Ribosomal 60S subunit protein L28; homologous to mammalian ribosomal protein L27A and bacterial L15; may have peptidyl transferase activity; can mutate to cycloheximide resistance cytoplasmic translation structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit|nucleus
YNL247W YNL247W YNL247W het Verified 0.0882193488796659 0.464851169545616 no 494 0.474045194966705 1594 0.001 FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION Cysteinyl-tRNA synthetase; may interact with ribosomes, based on co-purification experiments cysteinyl-tRNA aminoacylation cysteine-tRNA ligase activity ribosome|cytoplasm
YIL115C YIL115C NUP159 het Verified 0.0867936164869957 0.465417780891065 no 495 0.452468605606935 1484 0.001 FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes directly to nucleocytoplasmic transport; regulates ADP release from the ATP-dependent RNA helicase Dbp5p; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup116p) poly(A)+ mRNA export from nucleus|NLS-bearing substrate import into nucleus|protein export from nucleus|ribosomal large subunit export from nucleus|ncRNA export from nucleus|nuclear pore distribution|ribosomal small subunit export from nucleus nucleocytoplasmic transporter activity|adenyl-nucleotide exchange factor activity nuclear pore central transport channel|integral to membrane|nuclear pore cytoplasmic filaments|nuclear pore
YGL245W YGL245W GUS1 het Verified 0.085788411066801 0.465817309571433 no 496 0.472313646680261 1566 0.003 FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION MITOCHONDRION Glutamyl-tRNA synthetase (GluRS); forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm; protein abundance increases in response to DNA replication stress glutamyl-tRNA aminoacylation glutamate-tRNA ligase activity methionyl glutamyl tRNA synthetase complex|mitochondrion|cytoplasm
YKL012W YKL012W PRP40 het Verified 0.0827984869224567 0.467005886129537 no 497 0.460405693553899 1512 0.000 FT RNA PROCESSING NUCLEUS U1 snRNP protein involved in splicing, interacts with the branchpoint-binding protein during the formation of the second commitment complex mRNA splicing, via spliceosome RNA binding U1 snRNP|nucleus|U2-type prespliceosome
YDR361C YDR361C BCP1 het Verified 0.0824865011813469 0.467129926124925 no 498 0.478569212940916 1580 0.001 FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS NUCLEUS Essential protein involved in nuclear export of Mss4p, which is a lipid kinase that generates phosphatidylinositol 4,5-biphosphate and plays a role in actin cytoskeleton organization and vesicular transport protein export from nucleus|ribosomal large subunit export from nucleus molecular_function nucleus|cytoplasm
YKL060C YKL060C FBA1 het Verified 0.0815727939222935 0.467493218239995 no 499 0.472212171373656 1573 0.000 FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Fructose 1,6-bisphosphate aldolase, required for glycolysis and gluconeogenesis; catalyzes conversion of fructose 1,6 bisphosphate to glyceraldehyde-3-P and dihydroxyacetone-P; locates to mitochondrial outer surface upon oxidative stress gluconeogenesis|glycolysis fructose-bisphosphate aldolase activity cytosol|mitochondrion|cytoplasm
YPL266W YPL266W DIM1 het Verified 0.081132099505731 0.467668449055523 no 500 0.465820251101017 1546 0.001 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing rRNA modification|rRNA processing rRNA (adenine-N6,N6-)-dimethyltransferase activity nucleolus|90S preribosome
YER006W YER006W NUG1 het Verified 0.0802919561770689 0.468002527800469 no 501 0.46527159345732 1537 0.002 FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS GTPase that associates with nuclear 60S pre-ribosomes, required for export of 60S ribosomal subunits from the nucleus ribosomal large subunit export from nucleus|rRNA processing RNA binding|GTPase activity nucleolus|nucleus|preribosome, large subunit precursor
YLR196W YLR196W PWP1 het Verified 0.0784289204693125 0.468743434585143 no 502 0.470451067863794 1561 0.001 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily rRNA processing molecular_function nucleolus|nucleus|cytoplasm
YOR143C YOR143C THI80 het Verified 0.0778973985667031 0.468954834383867 no 503 0.460307415266024 1520 0.003 FT COFACTOR METABOLISM Thiamine pyrophosphokinase, phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate) thiamine diphosphate biosynthetic process thiamine diphosphokinase activity cytoplasm
YGR128C YGR128C UTP8 het Verified 0.0746456146838343 0.470248340033319 no 504 0.473313748466375 1553 0.002 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|RNA LOCALIZATION NUCLEUS|CHROMOSOME Nucleolar protein required for export of tRNAs from the nucleus; also copurifies with the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA positive regulation of transcription from RNA polymerase I promoter|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|tRNA export from nucleus snoRNA binding|tRNA binding small-subunit processome|t-UTP complex|nucleolus|rDNA heterochromatin|90S preribosome
YCL031C YCL031C RRP7 het Verified 0.0729120261187293 0.4709380619791 no 505 0.479888750206369 1587 0.000 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Essential protein involved in rRNA processing and ribosome biogenesis; protein abundance increases in response to DNA replication stress ribosomal small subunit assembly|rRNA processing molecular_function nucleolus|nucleus|UTP-C complex|CURI complex
YMR113W YMR113W FOL3 het Verified 0.0728077017089241 0.470979571073925 no 506 0.461341147902276 1532 0.001 FT KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM Dihydrofolate synthetase, involved in folic acid biosynthesis; catalyzes the conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis folic acid-containing compound biosynthetic process dihydrofolate synthase activity cytoplasm
YDL103C YDL103C QRI1 het Verified 0.071903314324196 0.471339426215032 no 507 0.477464614784298 1602 0.000 FT CARBOHYDRATE METABOLISM NUCLEUS UDP-N-acetylglucosamine pyrophosphorylase; catalyzes the formation of UDP-N-acetylglucosamine (UDP-GlcNAc), which is important in cell wall biosynthesis, protein N-glycosylation, and GPI anchor biosynthesis; protein abundance increases in response to DNA replication stress UDP-N-acetylglucosamine biosynthetic process UDP-N-acetylglucosamine diphosphorylase activity nucleus|cytoplasm
YDR013W YDR013W PSF1 het Verified 0.0716821612012505 0.471427426468234 no 508 0.465422313209447 1547 0.002 FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery double-strand break repair via break-induced replication|DNA-dependent DNA replication molecular_function GINS complex|replication fork protection complex|DNA replication preinitiation complex
YJL167W YJL167W ERG20 het Verified 0.0701039170960775 0.472055474491826 no 509 0.478665116423807 1584 0.001 FT LIPID METABOLISM ENDOPLASMIC RETICULUM Farnesyl pyrophosphate synthetase, has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis farnesyl diphosphate biosynthetic process|ergosterol biosynthetic process|isoprenoid biosynthetic process dimethylallyltranstransferase activity|geranyltranstransferase activity endoplasmic reticulum|cytoplasm
YKL083W_d YKL083W YKL083W het Dubious 0.0689611927275096 0.472510254822166 no 510 0.455312437982562 1497 0.000 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified essential gene RRP14 Unknown Unknown Unknown
YNL152W YNL152W INN1 het Verified 0.0686317815458161 0.472641360244051 no 511 0.465449372429884 1551 0.000 FT CELL CYCLE|CELL DIVISION SITE OF POLARIZED GROWTH|CYTOSKELETON Essential protein that associates with contractile actomyosin ring; required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function; activates chitin synthase activity of Chs2p during cytokinesis cytokinesis after mitosis|chromosome organization|barrier septum assembly involved in cell cycle cytokinesis|cytokinesis phospholipid binding cellular bud neck contractile ring|cytoplasm
YFL005W YFL005W SEC4 het Verified 0.068429397667813 0.472721910358007 no 512 0.484158292560214 1628 0.001 FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|SIGNALING|CELL DIVISION ENDOMEMBRANE SYSTEM|MITOCHONDRION|PLASMA MEMBRANE|CYTOSKELETON Rab family GTPase essential for vesicle-mediated exocytic secretion and autophagy; associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane bipolar cellular bud site selection|autophagy|exocytosis|Golgi to plasma membrane transport|small GTPase mediated signal transduction|ascospore-type prospore assembly|membrane addition at site of cytokinesis|vesicle fusion|cytokinesis GTP binding|GTPase activity mitochondrial outer membrane|vesicle|incipient cellular bud site|mitochondrion|transport vesicle|actin cap|plasma membrane
YJL109C YJL109C UTP10 het Verified 0.0670875831233776 0.473255989428549 no 513 0.47381630975215 1567 0.004 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS|MITOCHONDRION|CHROMOSOME Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; mutant has increased aneuploidy tolerance endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|positive regulation of transcription from RNA polymerase I promoter|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) snoRNA binding mitochondrion|90S preribosome|small-subunit processome|preribosome, small subunit precursor|integral to membrane|t-UTP complex|rDNA heterochromatin|nucleolus
YER147C YER147C SCC4 het Verified 0.0625947854373345 0.47504459094731 no 514 0.48069962065158 1592 0.003 FT PROTEIN LOCALIZATION|CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX double-strand break repair|establishment of protein localization to chromatin|rDNA condensation|mitotic chromosome condensation|mitotic sister chromatid cohesion molecular_function nuclear chromatin|SMC loading complex
YLR100W YLR100W ERG27 het Verified 0.0596556781690549 0.476214936262231 no 515 0.477108397095108 1598 0.003 FT LIPID METABOLISM|OXIDATION-REDUCTION PROCESS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION 3-keto sterol reductase, catalyzes the last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants are sterol auxotrophs ergosterol biosynthetic process 3-keto sterol reductase activity mitochondrial outer membrane|endoplasmic reticulum|endoplasmic reticulum membrane
YMR131C YMR131C RRB1 het Verified 0.0570128493930128 0.477267479727805 no 516 0.482941961308394 1609 0.003 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Essential nuclear protein involved in early steps of ribosome biogenesis; physically interacts with the ribosomal protein Rpl3p ribosome biogenesis molecular_function nucleolus
YDR172W YDR172W SUP35 het Verified 0.054122337517394 0.478418847781267 no 517 0.476151930956854 1587 0.001 FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|NUCLEOTIDE METABOLISM Translation termination factor eRF3, has a role in mRNA deadenylation and decay; altered protein conformation creates the [PSI(+)] prion that alters translational fidelity and results in a nonsense suppressor phenotype translational termination|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay translation release factor activity cytosol|translation release factor complex
YDR182W YDR182W CDC1 het Verified 0.0535817162957255 0.478634211932723 no 518 0.481945834415423 1597 0.002 FT CELL CYCLE|RESPONSE TO DNA DAMAGE|ION HOMEOSTASIS|CELL DIVISION|CYTOSKELETON ORGANIZATION|ION HOMEOSTASIS ENDOPLASMIC RETICULUM Putative lipid phosphatase of the endoplasmic reticulum; shows Mn2+ dependence and may affect Ca2+ signaling; mutants display actin and general growth defects and pleiotropic defects in cell cycle progression and organelle distribution DNA repair|cellular manganese ion homeostasis|dephosphorylation|actin cytoskeleton organization molecular_function integral to membrane|endoplasmic reticulum
YNL263C YNL263C YIF1 het Verified 0.051957829734705 0.479281147497932 no 519 0.474811993673538 1570 0.001 FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Integral membrane protein required for the fusion of ER-derived COPII transport vesicles with the Golgi; interacts with Yip1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; homolog of human YIPF3 ER to Golgi vesicle-mediated transport molecular_function integral to membrane|integral to Golgi membrane|endoplasmic reticulum membrane|ER to Golgi transport vesicle
YFL009W YFL009W CDC4 het Verified 0.050826149600889 0.479732026717052 no 520 0.471735348304806 1570 0.002 FT CELL CYCLE|CELL DIVISION|PROTEOLYSIS NUCLEUS UBIQUITIN LIGASE COMPLEX F-box protein required for G1/S and G2/M transition, associates with Skp1p and Cdc53p to form a complex, SCFCdc4, which acts as ubiquitin-protein ligase directing ubiquitination of the phosphorylated CDK inhibitor Sic1p meiosis|G2/M transition of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|G1/S transition of mitotic cell cycle ubiquitin-protein ligase activity|ubiquitin binding nuclear SCF ubiquitin ligase complex|SCF ubiquitin ligase complex|nucleus|nuclear matrix
YJL014W YJL014W CCT3 het Verified 0.0488476541258387 0.480520352488104 no 521 0.491638409066094 1643 0.000 FF Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo protein folding unfolded protein binding chaperonin-containing T-complex
YLR088W YLR088W GAA1 het Verified 0.0487104289074576 0.480575032338421 no 522 0.482210575356351 1605 0.000 FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Subunit of the GPI (glycosylphosphatidylinositol):protein transamidase complex, removes the GPI-anchoring signal and attaches GPI to proteins in the ER attachment of GPI anchor to protein GPI-anchor transamidase activity integral to membrane|GPI-anchor transamidase complex
YCL043C YCL043C PDI1 het Verified 0.0482576433053696 0.480755455472351 no 523 0.462041225045689 1524 0.001 FT ENDOPLASMIC RETICULUM Protein disulfide isomerase; multifunctional protein of ER lumen, essential for formation of disulfide bonds in secretory and cell-surface proteins, unscrambles non-native disulfide bonds; key regulator of Ero1p; forms complex with Mnl1p that has exomannosidase activity, processing unfolded protein-bound Man8GlcNAc2 oligosaccharides to Man7GlcNAc2, promoting degradation in unfolded protein response; PDI1 has a paralog, EUG1, that arose from the whole genome duplication protein folding protein disulfide oxidoreductase activity|protein disulfide isomerase activity endoplasmic reticulum lumen
YGR253C YGR253C PUP2 het Verified 0.0471000437198533 0.48121674624724 no 524 0.491196796783211 1638 0.004 FT PROTEOLYSIS ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process molecular_function mitochondrion|proteasome core complex, alpha-subunit complex|proteasome storage granule|nucleus|nuclear outer membrane-endoplasmic reticulum membrane network
YOR335C YOR335C ALA1 het Verified 0.0435050482034787 0.482649470226737 no 525 0.477822565544821 1599 0.001 FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Cytoplasmic and mitochondrial alanyl-tRNA synthetase, required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog alanyl-tRNA aminoacylation|mitochondrial alanyl-tRNA aminoacylation alanine-tRNA ligase activity mitochondrion|cytoplasm
YCL017C YCL017C NFS1 het Verified 0.042864996559787 0.482904575894585 no 526 0.485750653376034 1622 0.005 FT KETONE METABOLISM|RNA PROCESSING|AMINO ACID METABOLISM|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS|COFACTOR METABOLISM NUCLEUS|MITOCHONDRION Cysteine desulfurase involved in iron-sulfur cluster (Fe/S) biogenesis and in thio-modification of mitochondrial and cytoplasmic tRNAs; essential protein located predominantly in mitochondria cellular iron ion homeostasis|iron-sulfur cluster assembly|mitochondrial tRNA thio-modification|tRNA thio-modification|tRNA wobble uridine modification cysteine desulfurase activity mitochondrion|nucleus
YGL247W YGL247W BRR6 het Verified 0.0380808014965048 0.484811629196338 no 527 0.490038378906086 1647 0.002 FT PROTEIN LOCALIZATION|LIPID METABOLISM|MEMBRANE ORGANIZATION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS Essential nuclear envelope integral membrane protein required for nuclear envelope morphology, nuclear pore complex localization, nuclear export; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism mRNA export from nucleus|protein export from nucleus|cellular lipid metabolic process molecular_function nuclear envelope
YJL025W YJL025W RRN7 het Verified 0.0363666334060915 0.485495009627949 no 528 0.47058327112917 1570 0.002 FT NUCLEUS Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p transcription initiation from RNA polymerase I promoter|transcription of nuclear large rRNA transcript from RNA polymerase I promoter TBP-class protein binding|RNA polymerase I CORE element sequence-specific DNA binding|RNA polymerase I CORE element sequence-specific DNA binding transcription factor recruiting transcription factor activity nucleolus|RNA polymerase I core factor complex
YOR095C YOR095C RKI1 het Verified 0.0343970373378649 0.486280272968677 no 529 0.488540401512689 1630 0.001 FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS NUCLEUS Ribose-5-phosphate ketol-isomerase, catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway; participates in pyridoxine biosynthesis pyridoxine biosynthetic process|pentose-phosphate shunt ribose-5-phosphate isomerase activity nucleus|cytoplasm
YDR050C YDR050C TPI1 het Verified 0.0338064264246781 0.486515755665252 no 530 0.496316227589174 1659 0.001 FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS MITOCHONDRION Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region; inhibition of Tpi1p activity by PEP (phosphoenolpyruvate) stimulates redox metabolism in respiring cells; E104D mutation in human TPI causes a rare autosomal disease glycolysis triose-phosphate isomerase activity mitochondrion|plasma membrane|cytoplasm
YDR088C YDR088C SLU7 het Verified 0.0329915374490397 0.486840668053353 no 531 0.496760973895281 1691 0.002 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING NUCLEUS RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain generation of catalytic spliceosome for second transesterification step second spliceosomal transesterification activity spliceosomal complex
YLR007W YLR007W NSE1 het Verified 0.0310713187949439 0.487606331453679 no 532 0.483558473698584 1605 0.002 FT RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair DNA repair|postreplication repair molecular_function Smc5-Smc6 complex|nucleus
YOR272W YOR272W YTM1 het Verified 0.0294561576478021 0.488250392441665 no 533 0.480394432626027 1604 0.002 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Erb1p that is required for maturation of the large ribosomal subunit; has seven C-terminal WD repeats chromosome organization|ribosomal large subunit biogenesis molecular_function PeBoW complex|nucleolus|nucleus|preribosome, large subunit precursor
YLR022C YLR022C SDO1 het Verified 0.027845602640662 0.488892647200662 no 534 0.492392787842916 1651 0.001 FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS NUCLEUS Essential protein involved in ribosome maturation; with Ria1p, promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; ortholog of the human protein (SBDS) responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome; highly conserved across archaea and eukaryotes mature ribosome assembly molecular_function nucleus|preribosome, large subunit precursor|polysome|cytoplasm
YDR002W YDR002W YRB1 het Verified 0.0267116338221807 0.489344866997908 no 535 0.485079958491808 1612 0.001 FT PROTEIN LOCALIZATION|CELL CYCLE|PROTEOLYSIS|RNA LOCALIZATION NUCLEUS Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1 RNA export from nucleus|protein import into nucleus|G1/S transition of mitotic cell cycle|ubiquitin-dependent protein catabolic process Ran GTPase binding nucleus|cytoplasm
YKL122C YKL122C SRP21 het Verified 0.0252497320689957 0.489927884564709 no 536 0.487340751482088 1626 0.000 FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION NUCLEUS Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition|protein targeting to ER signal sequence binding nucleus|signal recognition particle, endoplasmic reticulum targeting
YPR105C YPR105C COG4 het Verified 0.0249567298180914 0.490044738725507 no 537 0.49356459319183 1632 0.005 FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments peroxisome degradation|intra-Golgi vesicle-mediated transport|retrograde transport, vesicle recycling within Golgi|macroautophagy|CVT pathway molecular_function Golgi transport complex
YGL098W YGL098W USE1 het Verified 0.0197939628989623 0.492103866925036 no 538 0.492961228362735 1652 0.001 FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Essential SNARE protein localized to the ER, involved in retrograde traffic from the Golgi to the ER; forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p retrograde vesicle-mediated transport, Golgi to ER|vesicle fusion with endoplasmic reticulum SNAP receptor activity SNARE complex|integral to cytosolic side of endoplasmic reticulum membrane
YMR240C YMR240C CUS1 het Verified 0.0187494139552593 0.492520504267373 no 539 0.49961966921336 1680 0.002 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING NUCLEUS Protein required for assembly of U2 snRNP into the spliceosome, forms a complex with Hsh49p and Hsh155p spliceosomal complex assembly|mRNA splicing, via spliceosome molecular_function U2 snRNP|U2-type prespliceosome
YMR288W YMR288W HSH155 het Verified 0.0168435741260658 0.493280703846966 no 540 0.474970513854689 1582 0.002 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING NUCLEUS U2-snRNP associated splicing factor that forms extensive associations with the branch site-3' splice site-3' exon region upon prespliceosome formation; similarity to the mammalian U2 snRNP-associated splicing factor SAP155 spliceosomal complex assembly|mRNA splicing, via spliceosome mRNA binding U2 snRNP|U2-type prespliceosome
YDL212W YDL212W SHR3 het Verified 0.0152757708792643 0.493906086133088 no 541 0.495662473056358 1691 0.006 FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface protein folding|ER to Golgi vesicle-mediated transport unfolded protein binding integral to endoplasmic reticulum membrane|integral to membrane|mating projection tip
YPL209C YPL209C IPL1 het Verified 0.0095009503254289 0.49620972623472 no 542 0.491140375257092 1636 0.000 FT PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME|CYTOSKELETON KINETOCHORE Aurora kinase subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), involved in regulating kinetochore-microtubule attachments; helps maintain condensed chromosomes during anaphase and early telophase; required for SPB cohesion and prevention of multipolar spindle formation; localizes to nuclear foci that become diffuse upon DNA replication stress; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon SAC arrest spindle checkpoint|attachment of spindle microtubules to kinetochore|chromosome segregation|mitotic spindle disassembly|protein phosphorylation|meiotic sister chromatid segregation|homologous chromosome segregation|regulation of cytokinesis|mitotic cell cycle G2/M transition decatenation checkpoint protein kinase activity spindle microtubule|spindle midzone|chromosome passenger complex|condensed nuclear chromosome kinetochore|kinetochore microtubule|spindle
YNL258C YNL258C DSL1 het Verified 0.00948041645734185 0.496217917693957 no 543 0.5 1678 0.004 FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PEROXISOME ORGANIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Peripheral membrane protein needed for Golgi-to-ER retrograde traffic; forms a complex with Sec39p and Tip20p that interacts with ER SNAREs Sec20p and Use1p; component of the ER target site that interacts with coatomer; interacts with Cin5p; similar to the fly and human ZW10 gene retrograde vesicle-mediated transport, Golgi to ER|ER-dependent peroxisome organization molecular_function Dsl1p complex|endoplasmic reticulum|peroxisome|nucleus
YBL004W YBL004W UTP20 het Verified 0.00518400971296799 0.497931888606546 no 544 0.493523754741417 1699 0.000 FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function nucleoplasm|small-subunit processome|preribosome, small subunit precursor|nucleolus|90S preribosome|cytoplasm
YMR112C YMR112C MED11 het Verified 0.00470619137982895 0.49812250820945 no 545 0.48907229650844 1636 0.001 FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential protein negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter TFIIH-class transcription factor binding|TFIIH-class transcription factor recruiting transcription factor activity core mediator complex
YBR196C YBR196C PGI1 het Verified 0.00352459296861874 0.498593893754899 no 546 0.46471072118287 1559 0.000 FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS MITOCHONDRION Glycolytic enzyme phosphoglucose isomerase, catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate; required for cell cycle progression and completion of the gluconeogenic events of sporulation gluconeogenesis|pentose-phosphate shunt|glycolysis glucose-6-phosphate isomerase activity cytosol|mitochondrion|plasma membrane
YKL182W YKL182W FAS1 het Verified 0.00311825973953675 0.498755996364646 no 547 0.487901806101979 1623 NA FF|FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities fatty acid biosynthetic process palmitoyltransferase activity|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|fatty acid synthase activity|3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity cytosol|fatty acid synthase complex|mitochondrion|lipid particle|cytoplasm
YIL126W YIL126W STH1 het Verified -0.00311825973953675 0.498755996364646 no 548 0.49307972787203 1706 NA FF|FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION NUCLEUS RSC COMPLEX ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p double-strand break repair|ATP-dependent chromatin remodeling|nucleosome positioning|chromosome segregation|chromatin remodeling at centromere|nucleosome disassembly|regulation of transcription, DNA-dependent|G2/M transition of mitotic cell cycle|meiosis|cytoskeleton organization|transcription elongation from RNA polymerase II promoter histone acetyl-lysine binding|DNA translocase activity|helicase activity|DNA-dependent ATPase activity RSC complex|nucleus
YNL088W YNL088W TOP2 het Verified -0.00461702678454373 0.49815807934992 no 549 0.49342616361148 1711 NA FT CELL CYCLE|CHROMATIN ORGANIZATION|CHROMOSOME SEGREGATION NUCLEUS|MITOCHONDRION|CHROMOSOME Topoisomerase II, relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis; required for replication slow zone (RSZ) breakage following Mec1p inactivation chromatin assembly or disassembly|chromatin remodeling at centromere|replication fork progression beyond termination site|mitotic cell cycle G2/M transition decatenation checkpoint|DNA topological change|DNA strand elongation involved in DNA replication|regulation of mitotic recombination|reciprocal meiotic recombination DNA topoisomerase (ATP-hydrolyzing) activity DNA replication termination region|synaptonemal complex|mitochondrion|nucleus
YNL061W YNL061W NOP2 het Verified -0.00610786066628653 0.497563331287805 no 550 0.497643299788258 1689 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles rRNA processing S-adenosylmethionine-dependent methyltransferase activity|RNA methyltransferase activity nucleolus|preribosome, large subunit precursor
YMR028W YMR028W TAP42 het Verified -0.00758171714124205 0.496975361451607 no 551 0.491035376770614 1635 NA FT SIGNALING Essential protein involved in the TOR signaling pathway; physically associates with the protein phosphatase 2A and the SIT4 protein phosphatase catalytic subunits TOR signaling cascade|positive regulation of transcription from RNA polymerase I promoter molecular_function cytosol|extrinsic to membrane
YLR167W YLR167W RPS31 het Verified -0.00983671049118738 0.496075783570201 no 552 0.486964457150126 1744 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|RESPONSE TO DNA DAMAGE|TRANSLATION NUCLEUS RIBOSOME Fusion protein cleaved to yield ribosomal protein S31 and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B; homologous to mammalian ribosomal protein S27A, no bacterial homolog cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S)|ribosomal small subunit assembly|ribosome biogenesis structural constituent of ribosome|protein tag cytosolic small ribosomal subunit|cytoplasm
YER146W YER146W LSM5 het Verified -0.00986626617100194 0.496063993132053 no 553 0.497030395194398 1686 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA nuclear-transcribed mRNA catabolic process|mRNA splicing, via spliceosome RNA binding U6 snRNP|nucleolus|small nucleolar ribonucleoprotein complex|U4/U6 x U5 tri-snRNP complex
YBR257W YBR257W POP4 het Verified -0.00998162790956741 0.496017972723233 no 554 0.484919445210323 1766 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P tRNA processing|intronic box C/D snoRNA processing|mRNA cleavage|rRNA processing ribonuclease MRP activity|ribonuclease P activity nucleolar ribonuclease P complex|ribonuclease MRP complex
YDR235W YDR235W PRP42 het Verified -0.0106452565305693 0.495753237292632 no 555 0.484264002072196 1627 NA FT RNA PROCESSING NUCLEUS U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats mRNA splicing, via spliceosome RNA binding U1 snRNP|U2-type prespliceosome
YMR059W YMR059W SEN15 het Verified -0.0123259856503994 0.495082767689203 no 556 0.488732061599209 1736 NA FT RNA PROCESSING ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p tRNA-type intron splice site recognition and cleavage tRNA-intron endonuclease activity tRNA-intron endonuclease complex
YLR045C YLR045C STU2 het Verified -0.014285066029725 0.4943012769996 no 557 0.495324900590311 1699 NA FT CELL CYCLE|CYTOSKELETON ORGANIZATION NUCLEUS|CHROMOSOME|CYTOSKELETON KINETOCHORE Microtubule-associated protein (MAP) of the XMAP215/Dis1 family; regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment; interacts with spindle pole body component Spc72p microtubule nucleation|mitotic spindle organization in nucleus microtubule binding|structural constituent of cytoskeleton cell cortex|spindle microtubule|condensed nuclear chromosome kinetochore|spindle pole body|kinetochore
YIL063C YIL063C YRB2 het Verified -0.0149828674175461 0.494022924334945 no 558 0.489550186930616 1720 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|GENE SILENCING ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE Protein of unknown function involved in nuclear processes of the Ran-GTPase cycle; involved in nuclear protein export; contains Ran Binding Domain and FxFG repeats; interacts with Srm1p, GTP-Gsp1p, Rna1p and Crm1p; is not essential protein export from nucleus|regulation of chromatin silencing at telomere|ribosomal small subunit export from nucleus molecular_function integral to membrane|nucleus|nuclear pore
YPR136C_d YPR136C YPR136C het Dubious -0.0174252049293783 0.493048700790286 no 559 0.492778810617115 1713 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF RRP9 Unknown Unknown Unknown
YER008C YER008C SEC3 het Verified -0.0190675933634314 0.492393591738878 no 560 0.485497159754557 1749 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION SITE OF POLARIZED GROWTH Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in a Rho1p-dependent, actin-independent manner, targeting and anchoring the exocyst to the plasma membrane with Exo70p; direct GTP Rho1p effector; required for ER inheritance; relocalizes away from bud neck upon DNA replication stress exocytosis|Golgi to plasma membrane transport|endoplasmic reticulum inheritance|exocyst localization|exocyst assembly|vesicle fusion|vesicle docking involved in exocytosis Rho GTPase binding|phosphatidylinositol-4,5-bisphosphate binding incipient cellular bud site|cellular bud neck|mating projection tip|exocyst|cellular bud tip
YPR186C YPR186C PZF1 het Verified -0.0204574798269771 0.491839215576778 no 561 0.485252068168718 1746 NA FT NUCLEUS Transcription factor IIIA (TFIIIA); essential DNA binding protein required for transcription of 5S rRNA by RNA polymerase III; not involved in transcription of other RNAP III genes; nine conserved zinc fingers; may also bind 5S rRNA 5S class rRNA transcription from RNA polymerase III type 1 promoter RNA polymerase III type 1 promoter sequence-specific DNA binding|TFIIIC-class transcription factor binding|RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIC recruiting transcription factor activity nucleus
YAL032C YAL032C PRP45 het Verified -0.0238640497530777 0.490480525125981 no 562 0.480733914069668 1769 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING NUCLEUS Protein required for pre-mRNA splicing; associates with the spliceosome and interacts with splicing factors Prp22p and Prp46p; orthologous to human transcriptional coactivator SKIP and can activate transcription of a reporter gene generation of catalytic spliceosome for second transesterification step first spliceosomal transesterification activity|second spliceosomal transesterification activity nucleus|post-mRNA release spliceosomal complex|U2-type catalytic step 2 spliceosome|U2-type catalytic step 1 spliceosome
YLR076C_d YLR076C YLR076C het Dubious -0.0280611226119679 0.48880670075743 no 563 0.48766454398275 1721 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPL10 which encodes the ribosomal protein L10 Unknown Unknown Unknown
YJR006W YJR006W POL31 het Verified -0.0284138677957277 0.488666031882925 no 564 0.491533619622645 1722 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Subunit of DNA polymerase delta (polymerase III); essential for cell viability; involved in DNA replication and DNA repair mismatch repair|RNA-dependent DNA replication|lagging strand elongation|base-excision repair|postreplication repair|DNA replication, removal of RNA primer|leading strand elongation|nucleotide-excision repair single-stranded DNA specific 3'-5' exodeoxyribonuclease activity|DNA-directed DNA polymerase activity delta DNA polymerase complex
YPR180W YPR180W AOS1 het Verified -0.0294208590470684 0.488264468445301 no 565 0.487429816819913 1714 NA FT RESPONSE TO DNA DAMAGE NUCLEUS Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability protein sumoylation SUMO activating enzyme activity nucleus|SUMO activating enzyme complex
YDR188W YDR188W CCT6 het Verified -0.0298611020483191 0.488088914036784 no 566 0.491940259294786 1645 NA Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif protein folding unfolded protein binding chaperonin-containing T-complex
YIL118W YIL118W RHO3 het Verified -0.029977172278545 0.488042629435055 no 567 0.494929194136691 1663 NA FT VESICLE-MEDIATED TRANSPORT|SIGNALING|CYTOSKELETON ORGANIZATION PLASMA MEMBRANE Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p positive regulation of formin-nucleated actin cable assembly|establishment or maintenance of actin cytoskeleton polarity|positive regulation of exocytosis GTP binding|GTPase activity cytosol|plasma membrane|cellular bud
YJL011C YJL011C RPC17 het Verified -0.0312937566107007 0.487517634737036 no 568 0.495083192480766 1658 NA FT NUCLEUS RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex; protein abundance increases in response to DNA replication stress transcription initiation from RNA polymerase III promoter|tRNA transcription from RNA polymerase III promoter DNA-directed RNA polymerase activity DNA-directed RNA polymerase III complex
YML043C YML043C RRN11 het Verified -0.0348606999035006 0.486095409242754 no 569 0.487178552192793 1636 NA FT NUCLEUS Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p transcription initiation from RNA polymerase I promoter|transcription of nuclear large rRNA transcript from RNA polymerase I promoter TBP-class protein binding|RNA polymerase I CORE element sequence-specific DNA binding|RNA polymerase I CORE element sequence-specific DNA binding transcription factor recruiting transcription factor activity RNA polymerase I core factor complex
YBR202W YBR202W MCM7 het Verified -0.0361169333570192 0.485594560135065 no 570 0.486928949431351 1722 NA FF|FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RESPONSE TO DNA DAMAGE|GENE SILENCING NUCLEUS|CHROMOSOME Component of the heterohexameric MCM2-7 complex, which primes origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation in S-phase; forms an Mcm4p-6p-7p subcomplex S phase of mitotic cell cycle|regulation of transcription from RNA polymerase II promoter|DNA replication initiation|DNA strand elongation involved in DNA replication|DNA unwinding involved in replication|pre-replicative complex assembly|double-strand break repair via break-induced replication|chromatin silencing at silent mating-type cassette|chromatin silencing at telomere DNA replication origin binding|single-stranded DNA-dependent ATPase activity|transcription cofactor activity|single-stranded DNA binding|ATP-dependent 3'-5' DNA helicase activity|ATP binding|four-way junction helicase activity|DNA helicase activity|chromatin binding replication fork protection complex|DNA replication preinitiation complex|nucleus|pre-replicative complex|cytoplasm|MCM complex
YDR460W YDR460W TFB3 het Verified -0.0379280069951587 0.484872541378401 no 571 0.479383343903537 1769 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION NUCLEUS RNA POL II, HOLOENZYME Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair; ring finger protein similar to mammalian CAK and TFIIH subunit phosphorylation of RNA polymerase II C-terminal domain|nucleotide-excision repair|transcription from RNA polymerase II promoter core RNA polymerase binding transcription factor activity holo TFIIH complex|TFIIK complex
YDR498C YDR498C SEC20 het Verified -0.0392418919312829 0.484348767205656 no 572 0.493332487560389 1711 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Membrane glycoprotein v-SNARE involved in retrograde transport from the Golgi to the ER; required for N- and O-glycosylation in the Golgi but not in the ER; interacts with the Dsl1p complex through Tip20p retrograde vesicle-mediated transport, Golgi to ER|vesicle fusion with endoplasmic reticulum SNAP receptor activity SNARE complex|integral to membrane|endoplasmic reticulum|peroxisome
YPR104C YPR104C FHL1 het Verified -0.0431413767605579 0.482794418050509 no 573 0.497291684584697 1669 NA FT TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS NUCLEUS|CHROMOSOME Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter|positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter RNA polymerase II transcription corepressor binding|RNA polymerase II transcription coactivator binding|sequence-specific DNA binding|DNA binding nuclear chromatin|nucleolus|nucleus|CURI complex
YNL261W YNL261W ORC5 het Verified -0.0433001889580786 0.482731120299201 no 574 0.478358952462942 1767 NA FT GENE SILENCING NUCLEUS|CHROMOSOME Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing regulation of chromatin silencing at telomere|DNA replication initiation|pre-replicative complex assembly|chromatin silencing at silent mating-type cassette DNA replication origin binding|ATP binding DNA replication preinitiation complex|pre-replicative complex|nuclear origin of replication recognition complex
YMR296C YMR296C LCB1 het Verified -0.0435239762087744 0.482641926190887 no 575 0.48547596732232 1736 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine sphingolipid biosynthetic process serine C-palmitoyltransferase activity SPOTS complex|serine C-palmitoyltransferase complex
YLR071C YLR071C RGR1 het Verified -0.0449459400681665 0.482075199471214 no 576 0.481833679721327 1746 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for glucose repression, HO repression, RME1 repression and sporulation negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II repressing transcription factor binding core mediator complex
YDR228C YDR228C PCF11 het Verified -0.0464856947491397 0.481461567848627 no 577 0.499609603120657 1677 NA FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS mRNA 3' end processing factor, essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II (Rpo21p); required for gene looping mRNA cleavage|termination of RNA polymerase II transcription|mRNA polyadenylation mRNA binding|RNA polymerase II core binding mRNA cleavage factor complex
YLR277C YLR277C YSH1 het Verified -0.0464928152597174 0.481458730243944 no 578 0.484142094963941 1736 NA FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS Putative endoribonuclease; subunit of the mRNA cleavage and polyadenylation specificity complex; required for 3' processing, splicing, and transcriptional termination of mRNAs and snoRNAs; protein abundance increases in response to DNA replication stress; YSH1 has a paralog, SYC1, that arose from the whole genome duplication termination of RNA polymerase II transcription|mRNA cleavage|mRNA polyadenylation|RNA splicing|snoRNA splicing|snoRNA 3'-end processing endoribonuclease activity|RNA binding mRNA cleavage factor complex|mRNA cleavage and polyadenylation specificity factor complex
YDR044W YDR044W HEM13 het Verified -0.0476532861124516 0.480996282028522 no 579 0.483957322410904 1743 NA FT OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; transcription is repressed by oxygen and heme (via Rox1p and Hap1p) heme biosynthetic process coproporphyrinogen oxidase activity cytosol
YFR037C YFR037C RSC8 het Verified -0.0476876376156678 0.480982593323939 no 580 0.494004761534107 1644 NA FF|FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS RSC COMPLEX Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters ATP-dependent chromatin remodeling|double-strand break repair via nonhomologous end joining|nucleosome disassembly|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|G1/S transition of mitotic cell cycle DNA translocase activity|DNA binding RSC complex|nucleus
YDL108W YDL108W KIN28 het Verified -0.0505854803823851 0.479827916494276 no 581 0.478683527764113 1756 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION NUCLEUS RNA POL II, HOLOENZYME Serine/threonine protein kinase, subunit of the transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promoters phosphorylation of RNA polymerase II C-terminal domain|transcription from RNA polymerase I promoter|protein phosphorylation|transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter core RNA polymerase binding transcription factor activity|RNA polymerase II carboxy-terminal domain kinase activity|cyclin-dependent protein kinase activating kinase activity|protein kinase activity TFIIK complex|holo TFIIH complex
YER148W YER148W SPT15 het Verified -0.0508743485919933 0.479712822945741 no 582 0.470600361859985 1805 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability transposon integration|transcription of nuclear large rRNA transcript from RNA polymerase I promoter|RNA polymerase II transcriptional preinitiation complex assembly|RNA polymerase III transcriptional preinitiation complex assembly RNA polymerase III regulatory region DNA binding|RNA polymerase I transcription factor recruiting transcription factor activity|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly|RNA polymerase II activating transcription factor binding|DNA binding, bending|sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding|TFIIIB-type transcription factor activity|chromatin binding|RNA polymerase I transcription factor binding transcription factor TFIIIB complex|RNA polymerase I upstream activating factor complex|nucleus|RNA polymerase I core factor complex|transcription factor TFIID complex
YBL035C YBL035C POL12 het Verified -0.052474164716618 0.479075440267763 no 583 0.498683318451492 1672 NA FT ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME B subunit of DNA polymerase alpha-primase complex, required for initiation of DNA replication during mitotic and premeiotic DNA synthesis; also functions in telomere capping and length regulation telomere capping|lagging strand elongation|DNA replication initiation DNA-directed DNA polymerase activity nuclear envelope|alpha DNA polymerase:primase complex|nucleus
YKL022C YKL022C CDC16 het Verified -0.0612108939492825 0.475595626943049 no 584 0.480076757014347 1765 NA FT CELL CYCLE|CELL DIVISION|PROTEOLYSIS NUCLEUS UBIQUITIN LIGASE COMPLEX Subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulation anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|negative regulation of DNA-dependent DNA replication initiation|protein ubiquitination ubiquitin-protein ligase activity anaphase-promoting complex
YDL014W YDL014W NOP1 het Verified -0.0637359763735969 0.474590228983683 no 585 0.472350177310459 1778 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Nucleolar protein, component of the small subunit processome complex, which is required for processing of pre-18S rRNA; has similarity to mammalian fibrillarin box C/D snoRNA 3'-end processing|rRNA processing|snoRNA processing|rRNA methylation rRNA methyltransferase activity small-subunit processome|box C/D snoRNP complex|ribosome|nucleolus|90S preribosome
YPR137W YPR137W RRP9 het Verified -0.0655871032297542 0.473853278568012 no 586 0.473109604773968 1780 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein rRNA modification|rRNA processing snoRNA binding box C/D snoRNP complex|small-subunit processome|nucleolus|90S preribosome
YOR159C YOR159C SME1 het Verified -0.065612879741536 0.473843017330286 no 587 0.462407833130093 1827 NA FT RNA PROCESSING NUCLEUS Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E mRNA splicing, via spliceosome molecular_function U1 snRNP|U2-type prespliceosome|U4/U6 x U5 tri-snRNP complex|U5 snRNP
YLR215C YLR215C CDC123 het Verified -0.0669403195995697 0.473314607303999 no 588 0.476910300133072 1767 NA FT CELL CYCLE|TRANSLATION|CELL DIVISION Protein involved in nutritional control of the cell cycle; regulates abundance of the translation initiation factor eIF2; ortholog of human D123 protein regulation of mitotic cell cycle|regulation of translation molecular_function cytoplasm
YKL141W YKL141W SDH3 het Verified -0.0701746860756241 0.472027311114193 no 589 0.484940499722917 1744 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Subunit of both succinate dehydrogenase and of TIM22 translocase; functions as the cytochrome b subunit of succinate dehydrogenase, which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; also required for mitochondrial inner membrane protein import as part of the TIM22 complex mitochondrial electron transport, succinate to ubiquinone|cellular respiration|tricarboxylic acid cycle|protein import into mitochondrial inner membrane succinate dehydrogenase (ubiquinone) activity mitochondrial respiratory chain complex II|mitochondrion|integral to membrane|mitochondrial inner membrane protein insertion complex
YIL004C YIL004C BET1 het Verified -0.0711325125165837 0.471646146226855 no 590 0.461399529045229 1833 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Type II membrane protein required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins retrograde vesicle-mediated transport, Golgi to ER|ER to Golgi vesicle-mediated transport|vesicle fusion SNAP receptor activity SNARE complex|integral to membrane|endoplasmic reticulum membrane|ER to Golgi transport vesicle
YBR049C YBR049C REB1 het Verified -0.0752622444409321 0.470003030410439 no 591 0.464888041764713 1806 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA polymerase I enhancer binding protein; DNA binding protein that binds to genes transcribed by both RNA polymerase I and RNA polymerase II; required for termination of RNA polymerase I transcription; REB1 has a paralog, NSI1, that arose from the whole genome duplication termination of RNA polymerase I transcription|regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding nucleoplasm
YIL019W YIL019W FAF1 het Verified -0.0762934391980904 0.469592822697028 no 592 0.481867279487101 1747 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Protein required for pre-rRNA processing and 40S ribosomal subunit assembly maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function nucleolus|nucleus|cytoplasm
YOL134C_d YOL134C YOL134C het Dubious -0.0804704244320705 0.467931558908491 no 593 0.466884133779391 1821 NA Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps HRT1, a verified gene that encodes an SCF ubiquitin ligase subunit Unknown Unknown Unknown
YDR437W YDR437W GPI19 het Verified -0.0825618317420252 0.467099975737737 no 594 0.461060781255051 1818 NA FT LIPID METABOLISM|CELL WALL ORG/BIOGENESIS ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Subunit of GPI-GlcNAc transferase involved in synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), which is the first intermediate in glycosylphosphatidylinositol (GPI) anchor synthesis, shares similarity with mammalian PIG-P GPI anchor biosynthetic process UDP-glycosyltransferase activity glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|nuclear envelope|integral to endoplasmic reticulum membrane|endoplasmic reticulum
YLR198C_d YLR198C YLR198C het Dubious -0.0855312951067553 0.465919508362477 no 595 0.48894122935762 1725 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIK1/YLR197W Unknown Unknown Unknown
YGR013W YGR013W SNU71 het Verified -0.0859644033562172 0.465747357223194 no 596 0.460309813982294 1827 NA FT RNA PROCESSING NUCLEUS Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart mRNA splicing, via spliceosome RNA binding U1 snRNP|U2-type prespliceosome
YNR054C YNR054C ESF2 het Verified -0.0863162885139487 0.465607495219584 no 597 0.449824041067066 1857 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|small-subunit processome assembly|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ATPase activator activity|RNA binding nucleolus|90S preribosome|cytoplasm
YNL245C YNL245C CWC25 het Verified -0.087885582619274 0.464983807832084 no 598 0.462561283560421 1817 NA FT RNA PROCESSING NUCLEUS Splicing factor required for the first step of pre-mRNA splicing; binding to the spliceosome requires Prp2p and Yju2p; heat-stable protein; has similarity to S. pombe Cwf25p mRNA splicing, via spliceosome molecular_function U2-type spliceosomal complex
YPL131W YPL131W RPL5 het Verified -0.0960296358042394 0.4617485176782 no 599 0.466657828719803 1830 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal 60S subunit protein L5; homologous to mammalian ribosomal protein L5 and bacterial L18; binds 5S rRNA and is required for 60S subunit assembly cytoplasmic translation|ribosomal large subunit assembly structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YGR265W_d YGR265W YGR265W het Dubious -0.0966065400847703 0.461519431277703 no 600 0.43724536749607 1912 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MES1/YGR264C, which encodes methionyl-tRNA synthetase Unknown Unknown Unknown
YDR531W YDR531W CAB1 het Verified -0.104649970930096 0.458326780649464 no 601 0.440736660888428 1894 NA FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM NUCLEUS Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway for synthesis of coenzyme A (CoA); transcriptionally regulated by Upc2p via a sterol response element coenzyme A biosynthetic process pantothenate kinase activity nucleus|cytoplasm
YLR153C YLR153C ACS2 het Verified -0.105487903984534 0.457994333829602 no 602 0.46388316078065 1817 NA FT CHROMATIN ORGANIZATION|COFACTOR METABOLISM NUCLEUS Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions histone acetylation|acetyl-CoA biosynthetic process|replicative cell aging acetate-CoA ligase activity|acid-ammonia (or amide) ligase activity cytosol|nucleolus|nucleus
YJR141W_p YJR141W YJR141W het Uncharacterized -0.106165712774087 0.457725437202995 no 603 0.444696805556958 1900 NA Essential protein of unknown function biological_process molecular_function cellular_component
YLR275W YLR275W SMD2 het Verified -0.108163463517803 0.456933013381791 no 604 0.454195616831731 1863 NA FT RNA PROCESSING NUCLEUS Core Sm protein Sm D2; part of heteroheptameric complex (with Smb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D2 mRNA splicing, via spliceosome molecular_function U1 snRNP|U4/U6 x U5 tri-snRNP complex|U2-type prespliceosome|U5 snRNP
YDL084W YDL084W SUB2 het Verified -0.113718454048567 0.454730491602625 no 605 0.465040165340198 1807 NA FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Component of the TREX complex required for nuclear mRNA export; member of the DEAD-box RNA helicase superfamily and is involved in early and late steps of spliceosome assembly; homolog of the human splicing factor hUAP56; relocalizes from nucleus to cytoplasm upon DNA replication stress mRNA 3'-end processing|mRNA export from nucleus|transcription-coupled nucleotide-excision repair|mRNA splicing, via spliceosome|transcription elongation from RNA polymerase II promoter|chromatin silencing at telomere ATP-dependent RNA helicase activity chromosome, telomeric region|nucleus|transcription export complex|spliceosomal complex
YOR261C YOR261C RPN8 het Verified -0.114753179894269 0.454320380420414 no 606 0.448046873695365 1879 NA FT PROTEOLYSIS Essential, non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11p ubiquitin-dependent protein catabolic process molecular_function proteasome storage granule|proteasome regulatory particle, lid subcomplex
YLR222C YLR222C UTP13 het Verified -0.115596372415017 0.453986219013427 no 607 0.474524384945284 1770 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) snoRNA binding small-subunit processome|nucleolus|Pwp2p-containing subcomplex of 90S preribosome|90S preribosome
YLR440C YLR440C SEC39 het Verified -0.115783144768503 0.453912204594879 no 608 0.443663538154769 1893 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PEROXISOME ORGANIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Component of the Dsl1p tethering complex that interacts with ER SNAREs Sec20p and Use1p; proposed to be involved in protein secretion; localizes to the ER and nuclear envelope retrograde vesicle-mediated transport, Golgi to ER|vesicle-mediated transport|ER-dependent peroxisome organization molecular_function Dsl1p complex|nuclear envelope|endoplasmic reticulum|peroxisome|endoplasmic reticulum membrane
YHR023W YHR023W MYO1 het Verified -0.120949182987626 0.451865642847149 no 609 0.454077696618218 1852 NA FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Type II myosin heavy chain, required for wild-type cytokinesis and cell separation; localizes to the actomyosin ring; binds to myosin light chains Mlc1p and Mlc2p through its IQ1 and IQ2 motifs respectively cytokinesis, actomyosin contractile ring assembly|cytokinesis, completion of separation|actomyosin contractile ring contraction|cytokinesis microfilament motor activity cellular bud neck contractile ring|incipient cellular bud site|cellular bud neck|myosin II complex
YNL244C YNL244C SUI1 het Verified -0.121892925603705 0.451491909199915 no 610 0.449536916729856 1858 NA FT TRANSLATION Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase translational initiation translation initiation factor binding|translation initiation factor activity multi-eIF complex
YGR120C YGR120C COG2 het Verified -0.121985517560991 0.451455243960069 no 611 0.450699617278175 1872 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments peroxisome degradation|ER to Golgi vesicle-mediated transport|macroautophagy|intra-Golgi vesicle-mediated transport|retrograde transport, vesicle recycling within Golgi|CVT pathway molecular_function Golgi transport complex|extrinsic to membrane
YPL204W YPL204W HRR25 het Verified -0.128313519221428 0.448950433376517 no 612 0.454514307237042 1838 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|RESPONSE TO DNA DAMAGE|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|CHROMOSOME SEGREGATION NUCLEUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CHROMOSOME|CYTOSKELETON KINETOCHORE Protein kinase involved in regulating diverse events including vesicular trafficking, DNA repair, and chromosome segregation; binds the CTD of RNA pol II; homolog of mammalian casein kinase 1delta (CK1delta) ribosomal small subunit biogenesis|DNA repair|mitosis|ER to Golgi vesicle-mediated transport|protein phosphorylation|attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation|tRNA wobble uridine modification protein serine/threonine kinase activity|protein kinase activity chromosome, centromeric region|plasma membrane|nucleus|spindle pole body|monopolin complex|cellular bud neck|cellular bud tip
YML069W YML069W POB3 het Verified -0.128696044572446 0.448799082678173 no 613 0.447376794618978 1877 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Subunit of the heterodimeric FACT complex (Spt16p-Pob3p); FACT associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; protein abundance increases in response to DNA replication stress DNA replication-independent nucleosome organization|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|regulation of transcription by chromatin organization|DNA-dependent DNA replication chromatin binding|nucleosome binding|histone binding nuclear chromatin|FACT complex|replication fork protection complex|alpha DNA polymerase:primase complex
YDR045C YDR045C RPC11 het Verified -0.12876603774051 0.448771389855668 no 614 0.439971625617143 1886 NA FT NUCLEUS RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS termination of RNA polymerase III transcription|tRNA transcription from RNA polymerase III promoter DNA-directed RNA polymerase activity DNA-directed RNA polymerase III complex
YJR093C YJR093C FIP1 het Verified -0.135108130593702 0.446263190920262 no 615 0.440496963411648 1903 NA FT RNA PROCESSING NUCLEUS Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; bridging factor that links Pap1p and the CPF complex via Yth1p mRNA cleavage|mRNA polyadenylation RNA binding|protein binding, bridging mRNA cleavage and polyadenylation specificity factor complex
YDR308C YDR308C SRB7 het Verified -0.142554368513519 0.443321068975974 no 616 0.438266379058894 1905 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; target of the global repressor Tup1p negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription coactivator activity|RNA polymerase II repressing transcription factor binding|RNA polymerase II transcription corepressor activity core mediator complex
YER038C YER038C KRE29 het Verified -0.145211072100439 0.442272112160287 no 617 0.439541805283522 1924 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Subunit of the SMC5-SMC6 complex; this complex is involved in removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance DNA repair molecular_function Smc5-Smc6 complex|nucleus|cytoplasm
YBR153W YBR153W RIB7 het Verified -0.145454758929649 0.442175916470662 no 618 0.436665979575005 1922 NA FT OXIDATION-REDUCTION PROCESS Diaminohydroxyphoshoribosylaminopyrimidine deaminase; catalyzes the second step of the riboflavin biosynthesis pathway riboflavin biosynthetic process 5-amino-6-(5-phosphoribosylamino)uracil reductase activity cellular_component
YKL145W YKL145W RPT1 het Verified -0.145487911644657 0.442162829657085 no 619 0.451146066153375 1837 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS NUCLEUS One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and Ubr1p; mutant has aneuploidy tolerance positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of protein catabolic process|proteasome regulatory particle assembly|ubiquitin-dependent protein catabolic process ATPase activity proteasome regulatory particle, base subcomplex
YOR168W YOR168W GLN4 het Verified -0.151125746800199 0.439938261371367 no 620 0.406496034249098 1992 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION MITOCHONDRION Glutamine tRNA synthetase, monomeric class I tRNA synthetase that catalyzes the specific glutaminylation of tRNA(Glu); N-terminal domain proposed to be involved in enzyme-tRNA interactions glutaminyl-tRNA aminoacylation glutamine-tRNA ligase activity cytosol|mitochondrion
YBL076C YBL076C ILS1 het Verified -0.153849872928294 0.438864054507249 no 621 0.438166882124028 1912 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION Cytoplasmic isoleucine-tRNA synthetase, target of the G1-specific inhibitor reveromycin A cytoplasmic translation|isoleucyl-tRNA aminoacylation isoleucine-tRNA ligase activity cytosol
YIR011C YIR011C STS1 het Verified -0.157641732887943 0.437369558310491 no 622 0.427581566428701 1947 NA FT PROTEIN LOCALIZATION|PROTEOLYSIS|CHROMOSOME SEGREGATION NUCLEUS Protein required for localizing proteasomes to the nucleus; interacts with the karyopherin Srp1p; involved in ubiquitin-mediated protein degradation proteasome localization|chromosome segregation|nucleus-associated proteasomal ubiquitin-dependent protein catabolic process molecular_function nucleus
YBR253W YBR253W SRB6 het Verified -0.158793283213851 0.43691587044259 no 623 0.442759914699787 1895 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation positive regulation of transcription from RNA polymerase II promoter molecular_function core mediator complex
YBR167C YBR167C POP7 het Verified -0.159439902469711 0.436661151678712 no 624 0.431279766796383 1930 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs tRNA processing|intronic box C/D snoRNA processing|mRNA cleavage|rRNA processing ribonuclease MRP activity|ribonuclease P activity nucleolar ribonuclease P complex|ribonuclease MRP complex
YPR161C YPR161C SGV1 het Verified -0.16008556140786 0.436406837407753 no 625 0.435477969073563 1940 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|PROTEIN PHOSPHORYLATION NUCLEUS Cyclin (Bur2p)-dependent protein kinase that functions in transcriptional regulation; phosphorylates the carboxy-terminal domain of Rpo21p and the C-terminal repeat domain of Spt5p; regulated by Cak1p; similar to metazoan CDK9 proteins phosphorylation of RNA polymerase II C-terminal domain|protein phosphorylation|transcription, DNA-dependent|positive regulation of histone H3-K4 methylation RNA polymerase II carboxy-terminal domain kinase activity|cyclin-dependent protein kinase activity cyclin-dependent protein kinase holoenzyme complex|nucleus
YBR102C YBR102C EXO84 het Verified -0.160629213556445 0.436192722286851 no 626 0.430179532852865 1946 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING SITE OF POLARIZED GROWTH Exocyst subunit with dual roles in exocytosis and spliceosome assembly; subunit of the the exocyst complex which mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane (PM) prior to SNARE-mediated fusion; required for exocyst assembly and targeting the complex to specific sites on the bud tip PM; associates the U1 snRNP; role in pre-mRNA splicing and prespliceosome formation; possible Cdc28 substrate spliceosomal complex assembly|Golgi to plasma membrane transport|exocyst localization|exocytosis|exocyst assembly molecular_function incipient cellular bud site|mating projection tip|cellular bud neck|cellular bud tip|exocyst
YNL251C YNL251C NRD1 het Verified -0.16277182284457 0.435349047235241 no 627 0.427940530253215 1940 NA FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3′ end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; interacts with the C-terminal domain of the RNA polymerase II large subunit (Rpo21p), preferentially at phosphorylated Ser5, to direct transcription termination of non-polyadenylated transcripts; H3K4 trimethylation of transcribed regions by Set1p enhances recruitment of Nrd1p to those sites mRNA 3'-end processing|nuclear mRNA surveillance|termination of RNA polymerase II transcription, exosome-dependent|antisense RNA transcript catabolic process|tRNA 3'-end processing|snRNA 3'-end processing|snoRNA 3'-end processing|CUT catabolic process RNA binding|transcription regulatory region RNA binding|protein domain specific binding Nrd1 complex|nucleus
YDR416W YDR416W SYF1 het Verified -0.164785803817718 0.434556289097624 no 628 0.432585362209274 1933 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING NUCLEUS Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; null mutant has splicing defect and arrests in G2/M; homologs in human and C. elegans generation of catalytic spliceosome for first transesterification step first spliceosomal transesterification activity|second spliceosomal transesterification activity U2-type post-mRNA release spliceosomal complex|Prp19 complex|U2-type prespliceosome|U2-type catalytic step 1 spliceosome|U2-type catalytic step 2 spliceosome
YGR046W YGR046W TAM41 het Verified -0.164994139151379 0.434474297557208 no 629 0.434474100553577 1909 NA FT PROTEIN LOCALIZATION|LIPID METABOLISM|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial protein required for cardiolipin biosynthesis; viability of null mutant is strain-dependent; mRNA is targeted to the bud; mutant displays defect in mitochondrial protein import, likely due to altered membrane lipid composition cardiolipin biosynthetic process|protein import into mitochondrial matrix molecular_function extrinsic to mitochondrial inner membrane|mitochondrion|mitochondrial matrix
YJL156C YJL156C SSY5 het Verified -0.166405163145987 0.433919055500977 no 630 0.43478919255611 1929 NA FT PROTEOLYSIS PLASMA MEMBRANE Serine protease of SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p); contains an inhibitory domain that dissociates in response to extracellular amino acids, freeing a catalytic domain to activate transcription factor Stp1p protein processing|response to amino acid stimulus serine-type endopeptidase activity extrinsic to plasma membrane
YPR168W YPR168W NUT2 het Verified -0.181063603142321 0.428158826421016 no 631 0.426789166751955 1962 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for transcriptional activation and has a role in basal transcription; protein abundance increases in response to DNA replication stress negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter molecular_function core mediator complex
YNL006W YNL006W LST8 het Verified -0.183551087038221 0.427182818962298 no 632 0.432891708703533 1944 NA FT SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION ENDOMEMBRANE SYSTEM|GOLGI APPARATUS|PLASMA MEMBRANE Protein required for the transport of amino acid permease Gap1p from the Golgi to the cell surface; component of the TOR signaling pathway; associates with both Tor1p and Tor2p; contains a WD-repeat transport|TOR signaling cascade|fungal-type cell wall organization|signal transduction|regulation of cell growth|establishment or maintenance of actin cytoskeleton polarity|mitochondria-nucleus signaling pathway protein kinase activator activity|protein binding TORC1 complex|TORC2 complex|endosome membrane|extrinsic to internal side of plasma membrane|Golgi membrane
YDR487C YDR487C RIB3 het Verified -0.189034482702067 0.425032895349978 no 633 0.413807584420801 1969 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION 3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase), required for riboflavin biosynthesis from ribulose-5-phosphate, also has an unrelated function in mitochondrial respiration riboflavin biosynthetic process|aerobic respiration 3,4-dihydroxy-2-butanone-4-phosphate synthase activity cytosol|mitochondrial intermembrane space
YLR008C YLR008C PAM18 het Verified -0.194291535586704 0.422973806488566 no 634 0.407362256131169 2012 NA FT PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Constituent of the import motor (PAM complex) component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); essential J-protein cochaperone that stimulates Ssc1p ATPase activity to drive import; inhibited by Pam16p protein import into mitochondrial matrix unfolded protein binding|ATPase activator activity mitochondrion|presequence translocase-associated import motor|mitochondrial inner membrane presequence translocase complex
YER171W YER171W RAD3 het Verified -0.195514657259429 0.422495032131216 no 635 0.428993295741171 1960 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION NUCLEUS RNA POL II, HOLOENZYME 5' to 3' DNA helicase; involved in nucleotide excision repair and transcription; subunit of RNA polII initiation factor TFIIH and of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress regulation of transposition, RNA-mediated|phosphorylation of RNA polymerase II C-terminal domain|nucleotide-excision repair, DNA incision|regulation of mitotic recombination|transcription from RNA polymerase II promoter damaged DNA binding|ATP-dependent 5'-3' DNA helicase activity|core RNA polymerase binding transcription factor activity core TFIIH complex|holo TFIIH complex|nucleotide-excision repair factor 3 complex
YJL174W YJL174W KRE9 het Verified -0.199591688678197 0.420899964235287 no 636 0.417402524340657 1984 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects (1->6)-beta-D-glucan metabolic process|fungal-type cell wall organization molecular_function extracellular region
YPR041W YPR041W TIF5 het Verified -0.2001498336211 0.42068170009616 no 637 0.418160791024157 1981 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Translation initiation factor eIF5; functions both as a GTPase-activating protein to mediate hydrolysis of ribosome-bound GTP and as a GDP dissociation inhibitor to prevent recycling of eIF2 mature ribosome assembly|negative regulation of translational initiation|regulation of translational initiation translation initiation factor binding|GDP-dissociation inhibitor activity|GTPase activator activity|translation initiation factor activity cytosolic small ribosomal subunit|multi-eIF complex
YIL091C YIL091C UTP25 het Verified -0.201633981327422 0.420101438777891 no 638 0.416607826678716 1967 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Nucleolar protein required for 35S pre-RNA processing and 40S ribosomal subunit biogenesis ribosomal small subunit biogenesis|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) U3 snoRNA binding|rRNA binding small-subunit processome|nucleolus|nucleus
YDR373W YDR373W FRQ1 het Verified -0.206202715929229 0.418316283215978 no 639 0.406161310570478 2029 NA FT SIGNALING ENDOMEMBRANE SYSTEM|GOLGI APPARATUS|PLASMA MEMBRANE N-myristoylated calcium-binding protein that may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p; member of the recoverin/frequenin branch of the EF-hand superfamily regulation of signal transduction enzyme activator activity|calcium ion binding Golgi membrane
YJL041W YJL041W NSP1 het Verified -0.206749966614378 0.418102566324214 no 640 0.417333582631834 1985 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RIBOSOME BIOGENESIS|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nup82p, Gle2p and two other FG-nucleoporins (Nup159p and Nup116p); also found in stable complex with Nic96p and two other FG-nucleoproteins (Nup49p and Nup57p); forms foci at the nuclear periphery upon DNA replication stress poly(A)+ mRNA export from nucleus|NLS-bearing substrate import into nucleus|ncRNA export from nucleus|ribosomal large subunit export from nucleus|tRNA export from nucleus|protein import into nucleus|ribosomal small subunit export from nucleus nucleocytoplasmic transporter activity|phospholipid binding|structural constituent of nuclear pore nuclear pore central transport channel|integral to membrane|nuclear pore nuclear basket|nuclear pore
YER009W YER009W NTF2 het Verified -0.212452942941904 0.415876842921638 no 641 0.416933867793898 1981 NA FT PROTEIN LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport nucleocytoplasmic transport|protein import into nucleus Ran GTPase binding nuclear envelope|integral to membrane
YMR079W YMR079W SEC14 het Verified -0.214038068999488 0.415258685125326 no 642 0.417654865723844 1983 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; has a role in localization of lipid raft proteins; functionally homologous to mammalian PITPs Golgi vesicle budding|phosphatidylinositol metabolic process|Golgi to plasma membrane protein transport|Golgi to vacuole transport|ascospore formation|Unknown|phospholipid transport phosphatidylinositol transporter activity|phosphatidylcholine transporter activity cytosol|Golgi apparatus|Golgi membrane|cytoplasm
YDR301W YDR301W CFT1 het Verified -0.215720918180315 0.414602647375508 no 643 0.4183532137531 1969 NA FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS|MITOCHONDRION RNA-binding subunit of the mRNA cleavage and polyadenylation factor; involved in poly(A) site recognition and required for both pre-mRNA cleavage and polyadenylation, 51% sequence similarity with mammalian AAUAA-binding subunit of CPSF mRNA cleavage|termination of RNA polymerase II transcription|mRNA polyadenylation RNA binding mRNA cleavage factor complex|mitochondrion|mRNA cleavage and polyadenylation specificity factor complex
YDR404C YDR404C RPB7 het Verified -0.221116235593584 0.412500964472683 no 644 0.481367372297472 1759 NA FF|FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|TRANSLATION NUCLEUS RNA POL II, HOLOENZYME RNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4p; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions; also involved in translation initiation transcription initiation from RNA polymerase II promoter|positive regulation of translational initiation|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|nuclear-transcribed mRNA catabolic process, exonucleolytic|transcription from RNA polymerase II promoter RNA-directed RNA polymerase activity|translation initiation factor binding|single-stranded RNA binding|single-stranded DNA binding nucleus|DNA-directed RNA polymerase II, core complex|cytoplasmic mRNA processing body|cytoplasm
YPL043W YPL043W NOP4 het Verified -0.2258463909956 0.410660447144163 no 645 0.397100932429559 2027 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs) rRNA processing RNA binding nucleolus
YGL169W YGL169W SUA5 het Verified -0.228075890489864 0.40979362138403 no 646 0.412746043040588 1977 NA FT RNA PROCESSING|TRANSLATION NUCLEUS|CHROMOSOME Single-stranded telomeric DNA-binding protein, required for normal telomere length; null mutant lacks N6-threonylcarbamoyl adenosine (t6A) modification in the anticodon loop of ANN-decoding tRNA; member of conserved YrdC/Sua5 family threonylcarbamoyladenosine metabolic process|telomere maintenance|regulation of translational fidelity single-stranded telomeric DNA binding cytoplasm
YLR105C YLR105C SEN2 het Verified -0.231059831258196 0.408634160378919 no 647 0.398268227733288 2037 NA FT RNA PROCESSING ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease tRNA-type intron splice site recognition and cleavage tRNA-intron endonuclease activity mitochondrial outer membrane|mitochondrion|tRNA-intron endonuclease complex
YLR339C_d YLR339C YLR339C het Dubious -0.231963444376156 0.408283203305757 no 648 0.390415754442255 2071 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPP0 Unknown Unknown Unknown
YKL193C YKL193C SDS22 het Verified -0.232910341335036 0.407915514017477 no 649 0.396790813108515 2027 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION NUCLEUS Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p; whether it functions as a positive or negative regulator of Glc7p is controversial; involved in the regulation of Glc7p nuclear localization and function maintenance of protein location in nucleus|chromosome segregation protein serine/threonine phosphatase inhibitor activity|protein phosphatase type 1 activator activity protein phosphatase type 1 complex|nucleus|cytoplasm
YBR109C YBR109C CMD1 het Verified -0.236363507973888 0.406575305207062 no 650 0.406910256721281 1985 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|LIPID METABOLISM|MEMBRANE ORGANIZATION|CELL DIVISION|CYTOSKELETON ORGANIZATION NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON Calmodulin; Ca++ binding protein that regulates Ca++ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca++ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin karyogamy involved in conjugation with cellular fusion|phosphatidylinositol biosynthetic process|NLS-bearing substrate import into nucleus|microautophagy|cell budding|vacuole fusion, non-autophagic|receptor-mediated endocytosis|cytoskeleton organization|spindle pole body organization|transcription factor import into nucleus calcium-dependent protein binding|protein binding|calcium ion binding incipient cellular bud site|central plaque of spindle pole body|mating projection tip|cellular bud neck|cellular bud tip
YKL036C_d YKL036C YKL036C het Dubious -0.239267667288053 0.405449017551215 no 651 0.406643518678795 2035 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the essential gene UGP1 gene and uncharacterized ORF YKL037W Unknown Unknown Unknown
YEL019C YEL019C MMS21 het Verified -0.240015436787489 0.405159144757973 no 652 0.398507769106304 2036 NA FT RESPONSE TO DNA DAMAGE ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME SUMO ligase and component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; mutants are sensitive to methyl methanesulfonate and show increased spontaneous mutation and mitotic recombination DNA repair SUMO ligase activity nuclear envelope|Smc5-Smc6 complex|nucleus|cytoplasm
YKL004W YKL004W AUR1 het Verified -0.240320425262763 0.405040930924155 no 653 0.415273731353759 1985 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance inositolphosphoceramide metabolic process|sphingolipid biosynthetic process inositol phosphoceramide synthase activity integral to membrane|Golgi apparatus|inositol phosphoceramide synthase complex
YLR078C YLR078C BOS1 het Verified -0.240918708096947 0.404809061085531 no 654 0.403333994514372 2017 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi ER to Golgi vesicle-mediated transport|vesicle fusion with Golgi apparatus|vesicle fusion SNAP receptor activity SNARE complex|integral to membrane|ER to Golgi transport vesicle membrane|endoplasmic reticulum membrane
YFR051C YFR051C RET2 het Verified -0.246888469696323 0.402497270005591 no 655 0.402009568136031 2025 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER retrograde vesicle-mediated transport, Golgi to ER|Golgi inheritance|ER to Golgi vesicle-mediated transport|Golgi localization molecular_function COPI vesicle coat
YNL038W YNL038W GPI15 het Verified -0.250880007268552 0.400953441035031 no 656 0.393348759020519 2058 NA FT LIPID METABOLISM ENDOPLASMIC RETICULUM Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-H protein GPI anchor biosynthetic process phosphatidylinositol N-acetylglucosaminyltransferase activity glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|integral to membrane
YFL017W-A YFL017W-A SMX2 het Verified -0.255109254474056 0.399319358282631 no 657 0.390423580682148 2062 NA FT RNA PROCESSING NUCLEUS Core Sm protein Sm G; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx3p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm G mRNA splicing, via spliceosome molecular_function U1 snRNP|U2-type prespliceosome|U4/U6 x U5 tri-snRNP complex|U5 snRNP
YLR066W YLR066W SPC3 het Verified -0.255556982002659 0.399146469448503 no 658 0.39030465600275 2055 NA FT PROTEIN LOCALIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23 signal peptide processing|protein targeting to ER peptidase activity signal peptidase complex
YDL060W YDL060W TSR1 het Verified -0.257960940125838 0.398218526237666 no 659 0.388512621295035 2070 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress rRNA processing|ribosome biogenesis ribonucleoprotein complex binding nucleolus|cytoplasm|90S preribosome
YMR213W YMR213W CEF1 het Verified -0.261619450692312 0.396807423348608 no 660 0.37620160088168 2094 NA FT CELL CYCLE|RNA PROCESSING NUCLEUS Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p mRNA splicing, via spliceosome first spliceosomal transesterification activity Prp19 complex|U2-type catalytic step 1 spliceosome
YBR254C YBR254C TRS20 het Verified -0.264388500787282 0.395740285710767 no 661 0.390971284614344 2065 NA FT VESICLE-MEDIATED TRANSPORT ENDOPLASMIC RETICULUM|GOLGI APPARATUS One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; mutations in the human homolog cause the spondyloepiphyseal dysplasia tarda (SEDL) disorder ER to Golgi vesicle-mediated transport molecular_function TRAPP complex
YPL044C_d YPL044C YPL044C het Dubious -0.269971855891211 0.393590952830879 no 662 0.375721793878181 2145 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP4/YPL043W Unknown Unknown Unknown
YJR123W YJR123W RPS5 het Verified -0.277956820792899 0.390522752536637 no 663 0.449054199254391 1865 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION RIBOSOME Protein component of the small (40S) ribosomal subunit; least basic of non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; homologous to mammalian ribosomal protein S5 and bacterial S7 cytoplasmic translation|rRNA export from nucleus|regulation of translational fidelity structural constituent of ribosome cytosolic small ribosomal subunit|90S preribosome
YLR145W YLR145W RMP1 het Verified -0.286377023853397 0.387294685213342 no 664 0.387225411437551 2075 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Subunit of RNase MRP, which processes pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; unlike most subunits, not shared between RNase MRP and nuclear RNase P maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|mRNA cleavage ribonuclease MRP activity nucleolus|nucleus|ribonuclease MRP complex|cytoplasm
YDL045C YDL045C FAD1 het Verified -0.28674599201755 0.387153409544903 no 665 0.380746524246888 2090 NA FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM Flavin adenine dinucleotide (FAD) synthetase, performs the second step in synthesis of FAD from riboflavin FAD biosynthetic process FMN adenylyltransferase activity cytoplasm
YML130C YML130C ERO1 het Verified -0.287443139597182 0.386886516785594 no 666 0.364986470023572 2150 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds protein folding|protein thiol-disulfide exchange thiol oxidase activity endoplasmic reticulum
YOR287C YOR287C RRP36 het Verified -0.288101634434441 0.386634470773667 no 667 0.372282573782342 2147 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Component of 90S preribosomes; involved in early cleavages of the 35S pre-rRNA and in production of the 40S ribosomal subunit ribosomal small subunit biogenesis|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|cleavage involved in rRNA processing molecular_function nucleolus|90S preribosome
YJL125C YJL125C GCD14 het Verified -0.292927271286438 0.384788871617108 no 668 0.380744148907721 2104 NA FT RNA PROCESSING NUCLEUS Subunit of tRNA (1-methyladenosine) methyltransferase, with Gcd10p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression tRNA methylation tRNA (adenine-N1-)-methyltransferase activity tRNA (m1A) methyltransferase complex|nucleus
YOL123W YOL123W HRP1 het Verified -0.29436632804933 0.384238996980587 no 669 0.371214776754388 2133 NA FT RNA PROCESSING NUCLEUS Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences mRNA cleavage|mRNA polyadenylation mRNA binding|RNA binding mRNA cleavage factor complex|nucleus|cytoplasmic stress granule|cytoplasm
YER022W YER022W SRB4 het Verified -0.297916672343361 0.382883381369612 no 670 0.379025643322276 2089 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; homozygosity of the human MED17 L371P mutation is associated with infantile cerebral and cerebellar atrophy with poor myelination transcription initiation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter activating transcription factor binding|structural molecule activity|core RNA polymerase II recruiting transcription factor activity core mediator complex
YLR438C-A YLR438C-A LSM3 het Verified -0.300408138210309 0.381932928404098 no 671 0.378089617225049 2099 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress nuclear-transcribed mRNA catabolic process|mRNA splicing, via spliceosome RNA binding U6 snRNP|nucleolus|small nucleolar ribonucleoprotein complex|U4/U6 x U5 tri-snRNP complex
YMR309C YMR309C NIP1 het Verified -0.300471472962261 0.381908776490602 no 672 0.416000426647249 1982 NA FT TRANSLATION eIF3c subunit of the eukaryotic translation initiation factor 3 (eIF3), involved in the assembly of preinitiation complex and start codon selection translational initiation translation initiation factor activity multi-eIF complex|eukaryotic translation initiation factor 3 complex|cytoplasmic stress granule|cytoplasm
YCL041C_d YCL041C YCL041C het Dubious -0.300936904466756 0.381731304127497 no 673 0.384452808739195 2099 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps both the verified gene PDI1/YCL043C and the uncharacterized gene YCL042W Unknown Unknown Unknown
YMR290C YMR290C HAS1 het Verified -0.311091921601152 0.37786537115033 no 674 0.358919594604365 2139 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS ENDOMEMBRANE SYSTEM|NUCLEUS ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles rRNA processing RNA binding|RNA-dependent ATPase activity|ATP-dependent RNA helicase activity nuclear envelope|nucleolus|preribosome, large subunit precursor|90S preribosome
YBL040C YBL040C ERD2 het Verified -0.318018720231308 0.375235368408277 no 675 0.357234154672049 2152 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM HDEL receptor, an integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteins protein retention in ER lumen|ER to Golgi vesicle-mediated transport HDEL sequence binding integral to endoplasmic reticulum membrane|integral to membrane
YJL001W YJL001W PRE3 het Verified -0.319571575774167 0.37464656226316 no 676 0.386915317364421 2052 NA FT PROTEOLYSIS ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Beta 1 subunit of the 20S proteasome, responsible for cleavage after acidic residues in peptides proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process endopeptidase activity nucleus|proteasome storage granule|endoplasmic reticulum membrane|proteasome core complex, beta-subunit complex
YDR164C YDR164C SEC1 het Verified -0.320987647346193 0.3741098759939 no 677 0.369005171443833 2163 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Sm-like protein involved in docking and fusion of exocytic vesicles; binds to assembled SNARE complexes at the membrane and stimulates membrane fusion; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function positive regulation of vesicle fusion|exocytosis|vesicle docking involved in exocytosis SNARE binding plasma membrane|cellular bud neck|cellular bud tip
YGL137W YGL137W SEC27 het Verified -0.325432473494299 0.372426890805531 no 678 0.40189612354867 2031 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Essential beta'-coat protein of the COPI coatomer, involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP retrograde vesicle-mediated transport, Golgi to ER|late endosome to vacuole transport via multivesicular body sorting pathway|ER to Golgi vesicle-mediated transport ubiquitin binding COPI vesicle coat
YKR086W YKR086W PRP16 het Verified -0.327534046127149 0.371631998326387 no 679 0.379342761809425 2122 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING NUCLEUS DEAH-box RNA helicase involved in second catalytic step of splicing; exhibits ATP-dependent RNA unwinding activity; mediates the release of Yju2p and Cwc25p in the second step; in the absence of ATP, stabilizes the binding of Cwc25p to the spliceosome in the first catalytic step generation of catalytic spliceosome for second transesterification step second spliceosomal transesterification activity|RNA-dependent ATPase activity U2-type catalytic step 2 spliceosome
YBR198C YBR198C TAF5 het Verified -0.339783558389389 0.367009765271907 no 680 0.361089164747173 2119 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS RNA POL II, HOLOENZYME|HISTONE ACETYLTRANSFERASE Subunit (90 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification histone acetylation|RNA polymerase II transcriptional preinitiation complex assembly|chromatin modification|transcription from RNA polymerase II promoter ubiquitin binding|chromatin binding|protein complex scaffold|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly SLIK (SAGA-like) complex|SAGA complex|transcription factor TFIID complex
YLR033W YLR033W RSC58 het Verified -0.341668548641172 0.366300171862949 no 681 0.428363391571415 1930 NA FF|FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION NUCLEUS RSC COMPLEX Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance nucleosome disassembly|transcription elongation from RNA polymerase II promoter|G1/S transition of mitotic cell cycle|chromatin remodeling molecular_function RSC complex
YNL149C YNL149C PGA2 het Verified -0.346154504214403 0.364613301946669 no 682 0.34432621191269 2250 NA FT PROTEIN LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect protein transport molecular_function nuclear envelope|endoplasmic reticulum
YOR074C YOR074C CDC21 het Verified -0.348509589066255 0.363728756826311 no 683 0.359212575439745 2153 NA FT NUCLEOTIDE METABOLISM NUCLEUS Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S dTMP biosynthetic process thymidylate synthase activity nucleus
YLR103C YLR103C CDC45 het Verified -0.350120614690257 0.36312409028158 no 684 0.342841087802271 2208 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|GENE SILENCING NUCLEUS|CHROMOSOME DNA replication initiation factor; recruited to MCM pre-RC complexes at replication origins; promotes release of MCM from Mcm10p, recruits elongation machinery; mutants in human homolog may cause velocardiofacial and DiGeorge syndromes S phase of mitotic cell cycle|regulation of chromatin silencing at telomere|DNA replication initiation|pre-replicative complex assembly|double-strand break repair via break-induced replication DNA replication origin binding|chromatin binding replication fork protection complex|nucleus|DNA replication preinitiation complex|nuclear replication fork|pre-replicative complex
YKL203C YKL203C TOR2 het Verified -0.350320539268602 0.363049076306827 no 685 0.357890650880819 2168 NA FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|MEMBRANE ORGANIZATION|RIBOSOME BIOGENESIS|SIGNALING|CYTOSKELETON ORGANIZATION MITOCHONDRION|PLASMA MEMBRANE PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication G1 phase of mitotic cell cycle|regulation of cell cycle|actin filament reorganization involved in cell cycle|positive regulation of endocytosis|regulation of cell growth|establishment or maintenance of actin cytoskeleton polarity|Rho protein signal transduction|ribosome biogenesis|signal transduction|TOR signaling cascade|cytoskeleton organization|negative regulation of autophagy protein binding|protein serine/threonine kinase activity TORC1 complex|TORC2 complex|mitochondrion|fungal-type vacuole membrane|extrinsic to internal side of plasma membrane|plasma membrane|cytoplasm
YJL039C YJL039C NUP192 het Verified -0.350894955816524 0.362833577928405 no 686 0.372094888611523 2115 NA FT PROTEIN LOCALIZATION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE Essential subunit of the inner ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport; homologous to human NUP205 nucleocytoplasmic transport|nuclear pore organization structural constituent of nuclear pore integral to membrane|nuclear pore nuclear basket|nuclear pore|nuclear pore inner ring
YOR282W_d YOR282W YOR282W het Dubious -0.351444135300483 0.36262758810886 no 687 0.351368952853789 2185 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C Unknown Unknown Unknown
YER157W YER157W COG3 het Verified -0.353993842516264 0.361671748905798 no 688 0.336445184742968 2235 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments peroxisome degradation|ER to Golgi vesicle-mediated transport|macroautophagy|retrograde transport, vesicle recycling within Golgi|intra-Golgi vesicle-mediated transport|CVT pathway protein transporter activity Golgi transport complex
YOR063W YOR063W RPL3 het Verified -0.354615283941343 0.361438912229005 no 689 0.365115082353112 2146 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal 60S subunit protein L3; homologous to mammalian ribosomal protein L3 and bacterial L3; involved in the replication and maintenance of killer double stranded RNA virus cytoplasmic translation|ribosomal large subunit assembly structural constituent of ribosome cytosolic large ribosomal subunit
YAL034W-A YAL034W-A MTW1 het Verified -0.356514541068137 0.360727632178515 no 690 0.342394610916492 2266 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME|CYTOSKELETON KINETOCHORE Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly chromosome segregation|protein localization to kinetochore molecular_function nuclear MIS12/MIND type complex|spindle pole
YOR260W YOR260W GCD1 het Verified -0.363594719513502 0.358080335251145 no 691 0.373646995433867 2126 NA FT TRANSLATION Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression regulation of translational initiation translation initiation factor activity|guanyl-nucleotide exchange factor activity eukaryotic translation initiation factor 2B complex|guanyl-nucleotide exchange factor complex
YMR235C YMR235C RNA1 het Verified -0.363692202823784 0.358043933227426 no 692 0.339018413660794 2250 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION|GENE SILENCING NUCLEUS GTPase activating protein (GAP) for Gsp1p, involved in nuclear transport rRNA metabolic process|ribosomal subunit export from nucleus|tRNA metabolic process|rRNA export from nucleus|RNA import into nucleus|protein import into nucleus|chromatin silencing at telomere Ran GTPase activator activity cytosol|integral to membrane|nucleus
YGR029W YGR029W ERV1 het Verified -0.365610826316478 0.35732774770188 no 693 0.360345951345926 2149 NA FT PROTEIN LOCALIZATION|ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS MITOCHONDRION Flavin-linked sulfhydryl oxidase of the mitochondrial intermembrane space (IMS), oxidizes Mia40p as part of a disulfide relay system that promotes IMS retention of imported proteins; ortholog of human hepatopoietin (ALR) cellular response to oxidative stress|cellular iron ion homeostasis|protein import into mitochondrial intermembrane space thiol oxidase activity|flavin-linked sulfhydryl oxidase activity mitochondrion|mitochondrial intermembrane space
YER093C YER093C TSC11 het Verified -0.369329321806562 0.355941136218571 no 694 0.353373249561759 2227 NA FT LIPID METABOLISM|SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION PLASMA MEMBRANE Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p), a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; involved in sphingolipid metabolism; contains a RasGEFN domain fungal-type cell wall organization|TOR signaling cascade|regulation of cell growth|establishment or maintenance of actin cytoskeleton polarity|sphingolipid biosynthetic process protein binding TORC2 complex
YOL120C YOL120C RPL18A het Verified -0.370212758783533 0.355611985392556 no 695 0.385014612612795 2101 NA FF|FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YMR013C YMR013C SEC59 het Verified -0.37196696100774 0.354958724241991 no 696 0.342015876727641 2239 NA FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Dolichol kinase, catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis; required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylation protein glycosylation dolichol kinase activity integral to membrane|endoplasmic reticulum membrane
YLL031C YLL031C GPI13 het Verified -0.374966228657236 0.353842791452627 no 697 0.366367525967315 2133 NA FT LIPID METABOLISM|CELL WALL ORG/BIOGENESIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM ER membrane localized phosphoryltransferase that adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein GPI anchor biosynthetic process mannose-ethanolamine phosphotransferase activity|transferase activity, transferring phosphorus-containing groups integral to membrane|endoplasmic reticulum
YER003C YER003C PMI40 het Verified -0.376850348432195 0.353142410890833 no 698 0.358051861610016 2200 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM NUCLEUS Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation protein glycosylation|cell wall mannoprotein biosynthetic process|GDP-mannose biosynthetic process mannose-6-phosphate isomerase activity nucleus|cytoplasm
YJL008C YJL008C CCT8 het Verified -0.377311045407576 0.352971232362048 no 699 0.329643067662656 2295 NA Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo protein folding unfolded protein binding chaperonin-containing T-complex|cytoplasm
YFR027W YFR027W ECO1 het Verified -0.383272864315293 0.350758728518895 no 700 0.331295312878358 2242 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Acetyltransferase; required for establishment of sister chromatid cohesion; acetylates Mps3p to regulate nuclear organization; modifies Smc3p at replication forks and Mcd1p in response to ds DNA breaks; has a C2H2-type zinc finger; mutations in human homolog ESCO2 cause Roberts syndrome; relative distribution to the nucleus increases upon DNA replication stress double-strand break repair|regulation of DNA replication|mitotic chromosome condensation|internal peptidyl-lysine acetylation|establishment of mitotic sister chromatid cohesion|DNA repair|chromosome organization|DNA replication|regulation of mitosis|telomere organization|tRNA gene clustering acetyltransferase activity|chromatin binding nuclear chromatin|nuclear replication fork
YER048W-A YER048W-A ISD11 het Verified -0.38554346988136 0.349917403284742 no 701 0.350807157249663 2208 NA FT COFACTOR METABOLISM MITOCHONDRION Cysteine desulfurase (Nfs1p) activator; essential for the formation of the persulfide intermediate at the desulfurase active site during pyridoxal phosphate-dependent desulfuration of cysteine; required for mitochondrial iron-sulfur cluster biosynthesis iron-sulfur cluster assembly enzyme activator activity extrinsic to mitochondrial inner membrane|mitochondrion|mitochondrial matrix
YAL003W YAL003W EFB1 het Verified -0.38620526885064 0.349672325959291 no 702 0.347716688064036 2213 NA FT TRANSLATION RIBOSOME Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site translational elongation translation elongation factor activity|guanyl-nucleotide exchange factor activity ribosome|eukaryotic translation elongation factor 1 complex
YPR019W YPR019W MCM4 het Verified -0.386430013326346 0.34958911285005 no 703 0.324585923776639 2296 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Essential helicase component of heterohexameric MCM2-7 complexes which bind pre-replication complexes on DNA and melt DNA prior to replication; forms an Mcm4p-6p-7p subcomplex; shows nuclear accumulation in G1; homolog of S. pombe Cdc21p S phase of mitotic cell cycle|DNA strand elongation involved in DNA replication|DNA unwinding involved in replication|double-strand break repair via break-induced replication|DNA replication initiation|pre-replicative complex assembly four-way junction helicase activity|DNA helicase activity|DNA replication origin binding|single-stranded DNA-dependent ATPase activity|single-stranded DNA binding|ATP-dependent 3'-5' DNA helicase activity replication fork protection complex|nuclear replication fork|DNA replication preinitiation complex|nucleus|pre-replicative complex|cytoplasm|MCM complex
YLR378C YLR378C SEC61 het Verified -0.388530762205417 0.348811646818096 no 704 0.336885099859784 2258 NA FT PROTEIN LOCALIZATION|PROTEOLYSIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER posttranslational protein targeting to membrane, translocation|retrograde protein transport, ER to cytosol|ER-associated protein catabolic process|SRP-dependent cotranslational protein targeting to membrane, translocation|peptide transport peptide transporter activity|P-P-bond-hydrolysis-driven protein transmembrane transporter activity|signal sequence binding integral to membrane|Sec61 translocon complex
YJR045C YJR045C SSC1 het Verified -0.392765948116121 0.347246178552378 no 705 0.379967162300489 2096 NA FT PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION NUCLEUS|MITOCHONDRION Hsp70 family ATPase; constituent of the import motor component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein translocation and folding; subunit of SceI endonuclease; SSC1 has a paralog, ECM10, that arose from the whole genome duplication protein refolding|positive regulation of endodeoxyribonuclease activity|protein import into mitochondrial matrix|protein unfolding enzyme regulator activity|ATPase activity mitochondrial nucleoid|mitochondrion|TRC complex|mitochondrial inner membrane|presequence translocase-associated import motor
YGL074C_d YGL074C YGL074C het Dubious -0.398332113715739 0.345192695760302 no 706 0.34175076780751 2230 NA Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential HSF1 gene encoding heat shock transcription factor Unknown Unknown Unknown
YGL155W YGL155W CDC43 het Verified -0.400467910940862 0.344405956892977 no 707 0.343133517834133 2230 NA FT SIGNALING|ION HOMEOSTASIS|ION HOMEOSTASIS|PROTEIN PRENYLATION Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis cellular calcium ion homeostasis|protein geranylgeranylation|establishment of cell polarity|small GTPase mediated signal transduction protein geranylgeranyltransferase activity|CAAX-protein geranylgeranyltransferase activity CAAX-protein geranylgeranyltransferase complex|intracellular
YBR091C YBR091C TIM12 het Verified -0.400566286562321 0.344369735586687 no 708 0.347450228251819 2208 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins protein import into mitochondrial inner membrane phospholipid binding|protein channel activity mitochondrion|integral to membrane|mitochondrial inner membrane protein insertion complex
YNR017W YNR017W TIM23 het Verified -0.401079378893859 0.34418084124908 no 709 0.345092666060181 2208 NA FT PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein import into mitochondrial matrix and inner membrane; with Tim17p, contributes to architecture and function of the import channel protein import into mitochondrial matrix mitochondrion targeting sequence binding|protein channel activity mitochondrion|integral to membrane|mitochondrial inner membrane presequence translocase complex
YKR079C YKR079C TRZ1 het Verified -0.401362928449938 0.344076469486469 no 710 0.321766777810124 2277 NA FT RNA PROCESSING NUCLEUS|MITOCHONDRION tRNA 3'-end processing endonuclease tRNase Z; also localized to mitochondria and interacts genetically with Rex2 exonuclease; homolog of the human candidate prostate cancer susceptibility gene ELAC2 tRNA 3'-trailer cleavage, endonucleolytic 3'-tRNA processing endoribonuclease activity mitochondrion|nucleus|cytoplasm
YOR326W YOR326W MYO2 het Verified -0.407809645660005 0.341706715780279 no 711 0.333493935712875 2252 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|PEROXISOME ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Type V myosin motor involved in actin-based transport of cargos; required for the polarized delivery of secretory vesicles, the vacuole, late Golgi elements, peroxisomes, and the mitotic spindle; MYO2 has a paralog, MYO4, that arose from the whole genome duplication vacuole inheritance|establishment of mitotic spindle orientation|peroxisome inheritance|budding cell apical bud growth|unidimensional cell growth|mitochondrion inheritance|membrane addition at site of cytokinesis|vesicle transport along actin filament|vesicle-mediated transport|Golgi inheritance microfilament motor activity|actin filament binding|calmodulin binding fungal-type vacuole membrane|incipient cellular bud site|filamentous actin|myosin V complex|actin filament bundle|cellular bud neck|cellular bud tip|vesicle|mating projection tip
YGR198W YGR198W YPP1 het Verified -0.409323733691784 0.341151050224582 no 712 0.321279470478481 2285 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT PLASMA MEMBRANE|CYTOSKELETON Cargo-transport protein involved in endocytosis; interacts with phosphatidylinositol-4-kinase Stt4; GFP-fusion protein localizes to the cytoplasm; YGR198W is an essential gene receptor-mediated endocytosis|response to pheromone|protein targeting to vacuole molecular_function endosome|cytosol|ribosome|plasma membrane|actin cortical patch|cytoplasm
YDR397C YDR397C NCB2 het Verified -0.413335916045229 0.339680259567429 no 713 0.311916118366274 2329 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Subunit of a heterodimeric NC2 transcription regulator complex with Bur6p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2beta negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter transcription coactivator activity|transcription corepressor activity nucleus|negative cofactor 2 complex
YKR002W YKR002W PAP1 het Verified -0.414354697804039 0.339307180527576 no 714 0.344245313334782 2218 NA FT RNA PROCESSING NUCLEUS Poly(A) polymerase, one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs; required for gene looping mRNA polyadenylation|snoRNA polyadenylation polynucleotide adenylyltransferase activity nucleoplasm|mRNA cleavage and polyadenylation specificity factor complex
YNL124W YNL124W NAF1 het Verified -0.425631382002692 0.335188234652777 no 715 0.325016019480359 2279 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS RNA-binding protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p box H/ACA snoRNP assembly RNA binding nucleoplasm|nucleus
YGL112C YGL112C TAF6 het Verified -0.426735210754187 0.334786100630181 no 716 0.362768067979286 2164 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS RNA POL II, HOLOENZYME|HISTONE ACETYLTRANSFERASE Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4 histone acetylation|RNA polymerase II transcriptional preinitiation complex assembly|chromatin modification|transcription from RNA polymerase II promoter chromatin binding|RNA polymerase II activating transcription factor binding|protein complex scaffold|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly SLIK (SAGA-like) complex|SAGA complex|transcription factor TFIID complex
YIL147C YIL147C SLN1 het Verified -0.427401050903479 0.334543621054421 no 717 0.325151466250399 2283 NA FT SIGNALING|PROTEIN PHOSPHORYLATION PLASMA MEMBRANE Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators negative regulation of protein kinase activity|protein autophosphorylation|peptidyl-histidine phosphorylation|osmosensory signaling pathway via two-component system osmosensor activity|protein histidine kinase activity|histidine phosphotransfer kinase activity plasma membrane|integral to plasma membrane
YKL173W YKL173W SNU114 het Verified -0.4285379953764 0.33412973855219 no 718 0.344659456192857 2239 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|NUCLEOTIDE METABOLISM NUCLEUS GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2 assembly of spliceosomal tri-snRNP|spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)|mRNA splicing, via spliceosome|generation of catalytic spliceosome for first transesterification step GTP binding|GTPase activity|U5 snRNA binding U4/U6 x U5 tri-snRNP complex|U5 snRNP
YNL290W YNL290W RFC3 het Verified -0.428730048049241 0.334059845407217 no 719 0.306447998524487 2310 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon mismatch repair|sister chromatid cohesion|leading strand elongation DNA clamp loader activity|ATPase activity Elg1 RFC-like complex|DNA replication factor C complex|Rad17 RFC-like complex|nucleus|Ctf18 RFC-like complex
YKL028W YKL028W TFA1 het Verified -0.430217808906494 0.333518604244184 no 720 0.343951276436886 2217 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS|MITOCHONDRION RNA POL II, HOLOENZYME TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening transcriptional open complex formation at RNA polymerase II promoter|transcription from RNA polymerase II promoter single-stranded DNA binding|TFIIH-class transcription factor binding|RNA polymerase II core binding mitochondrion|transcription factor TFIIE complex
YPR056W YPR056W TFB4 het Verified -0.43133547067527 0.333112231331064 no 721 0.340067760676846 2251 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION NUCLEUS RNA POL II, HOLOENZYME Subunit of TFIIH complex, involved in transcription initiation, similar to 34 kDa subunit of human TFIIH; interacts with Ssl1p phosphorylation of RNA polymerase II C-terminal domain|nucleotide-excision repair|transcription from RNA polymerase II promoter core RNA polymerase binding transcription factor activity core TFIIH complex|holo TFIIH complex|nucleotide-excision repair factor 3 complex
YPL075W YPL075W GCR1 het Verified -0.444092181712926 0.328487969391708 no 722 0.327903167222573 2311 NA FT TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY ENDOMEMBRANE SYSTEM|NUCLEUS Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p negative regulation of transcription from RNA polymerase II promoter by glucose|nucleosome organization|positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter|regulation of glycolysis by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from a mobile element promoter|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II distal enhancer sequence-specific DNA binding|RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nuclear envelope
YEL032W YEL032W MCM3 het Verified -0.445383764198241 0.328021221643931 no 723 0.341459151672255 2229 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|GENE SILENCING NUCLEUS|CHROMOSOME Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex S phase of mitotic cell cycle|DNA strand elongation involved in DNA replication|double-strand break repair via break-induced replication|DNA replication initiation|pre-replicative complex assembly|chromatin silencing at telomere|chromatin silencing at silent mating-type cassette DNA helicase activity|chromatin binding|DNA replication origin binding|ATPase activity replication fork protection complex|DNA replication preinitiation complex|pre-replicative complex|nucleus|cytoplasm|MCM complex
YLR175W YLR175W CBF5 het Verified -0.447179619053965 0.32737268784869 no 724 0.318535776510794 2322 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|CELL DIVISION NUCLEUS|CHROMOSOME|CYTOSKELETON Pseudouridine synthase catalytic subunit of box H/ACA small nucleolar ribonucleoprotein particles (snoRNPs), acts on both large and small rRNAs and on snRNA U2; mutations in human ortholog dyskerin cause the disorder dyskeratosis congenita box H/ACA snoRNA 3'-end processing|rRNA pseudouridine synthesis|rRNA processing|snRNA pseudouridine synthesis pseudouridine synthase activity box H/ACA snoRNP complex|nucleolus|90S preribosome
YFL038C YFL038C YPT1 het Verified -0.447237155156711 0.327351918538603 no 725 0.334101894478105 2246 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|SIGNALING|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p) Golgi vesicle budding|Golgi vesicle docking|early endosome to Golgi transport|macroautophagy|endocytic recycling|protein complex assembly|CVT pathway|retrograde vesicle-mediated transport, Golgi to ER|SNARE complex disassembly|ER to Golgi vesicle-mediated transport|COPII-coated vesicle budding SNARE binding|GTPase activity trans-Golgi network|mitochondrion|Golgi stack|endoplasmic reticulum membrane|Golgi membrane|pre-autophagosomal structure
YMR149W YMR149W SWP1 het Verified -0.449847410630669 0.326410234758304 no 726 0.303799130853216 2367 NA FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Delta subunit of the oligosaccharyl transferase glycoprotein complex, which is required for N-linked glycosylation of proteins in the endoplasmic reticulum protein N-linked glycosylation dolichyl-diphosphooligosaccharide-protein glycotransferase activity oligosaccharyltransferase complex|integral to membrane
YER159C YER159C BUR6 het Verified -0.452734099648477 0.325370111010622 no 727 0.299428251415333 2347 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter transcription coactivator activity|transcription corepressor activity nucleus|negative cofactor 2 complex
YGL102C_d YGL102C YGL102C het Dubious -0.453502458801886 0.325093486610097 no 728 0.323400614272017 2269 NA Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential RPL28 gene encoding a large subunit ribosomal protein Unknown Unknown Unknown
YKL042W YKL042W SPC42 het Verified -0.454537486181063 0.324721008778965 no 729 0.348229111240093 2209 NA FT CELL CYCLE|CYTOSKELETON ORGANIZATION NUCLEUS|CYTOSKELETON Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane microtubule nucleation|spindle pole body duplication associated with nuclear envelope structural constituent of cytoskeleton central plaque of spindle pole body|intermediate layer of spindle pole body
YFR042W YFR042W KEG1 het Verified -0.457569946951664 0.323630719458587 no 730 0.323412585040095 2301 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Integral membrane protein of the ER; physically interacts with Kre6p; has a role in the synthesis of beta-1,6-glucan in the cell wall; required for cell viability chromosome organization|(1->6)-beta-D-glucan biosynthetic process molecular_function integral to endoplasmic reticulum membrane|integral to membrane
YDR118W YDR118W APC4 het Verified -0.462540931566749 0.321846728290217 no 731 0.307149776937255 2336 NA FT CELL CYCLE|CELL DIVISION|PROTEOLYSIS NUCLEUS UBIQUITIN LIGASE COMPLEX Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to the nucleus increases upon DNA replication stress anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination ubiquitin-protein ligase activity anaphase-promoting complex
YGR082W YGR082W TOM20 het Verified -0.466422228758217 0.320456651721781 no 732 0.287243881362183 2384 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|RNA LOCALIZATION MITOCHONDRION Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins tRNA import into mitochondrion|protein import into mitochondrial matrix|mitochondrial outer membrane translocase complex assembly protein channel activity|mitochondrion targeting sequence binding mitochondrial outer membrane|mitochondrion|integral to membrane|integral to mitochondrial outer membrane|mitochondrial outer membrane translocase complex
YJL019W YJL019W MPS3 het Verified -0.466513597409485 0.320423958500856 no 733 0.311069200786451 2324 NA FT CELL CYCLE|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME|CYTOSKELETON Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p meiotic telomere clustering|synapsis|nuclear migration involved in conjugation with cellular fusion|spindle pole body duplication associated with nuclear envelope|telomere tethering at nuclear periphery|mitotic sister chromatid cohesion molecular_function nuclear envelope|nuclear periphery|integral to membrane|nuclear chromosome, telomeric region|half bridge of spindle pole body
YKL125W YKL125W RRN3 het Verified -0.470941665778215 0.318841196396936 no 734 0.321459967994134 2288 NA FT NUCLEUS Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNA; structure reveals unique HEAT repeat fold and a surface serine patch; phosphorylation of serine patch impairs cell growth and reduces RNA polymerase I binding in vitro and RNA polymerase I recruitment to the rDNA gene in vivo transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript core RNA polymerase I binding transcription factor activity|RNA polymerase I transcription factor binding transcription factor activity|RNA polymerase I transcription factor binding|RNA polymerase I core binding nucleolus
YDL221W_d YDL221W YDL221W het Dubious -0.471346597187587 0.318696622502307 no 735 0.302589433544086 2351 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 3' end of essential gene CDC13 Unknown Unknown Unknown
YDR243C YDR243C PRP28 het Verified -0.473182038790658 0.318041655437345 no 736 0.304983512110086 2331 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING NUCLEUS RNA helicase in the DEAD-box family, involved in RNA isomerization at the 5' splice site cis assembly of pre-catalytic spliceosome ATP-dependent RNA helicase activity spliceosomal complex|U5 snRNP
YKL052C YKL052C ASK1 het Verified -0.477854953476016 0.31637672249255 no 737 0.278528108380977 2413 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME|CYTOSKELETON KINETOCHORE Essential subunit of the Dam1 complex (aka DASH complex); couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; phosphorylated during the cell cycle by cyclin-dependent kinases; protein abundance increases in response to DNA replication stress attachment of spindle microtubules to kinetochore|attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|mitotic spindle organization in nucleus|regulation of microtubule polymerization or depolymerization|mitotic sister chromatid segregation microtubule binding|structural constituent of cytoskeleton condensed nuclear chromosome kinetochore|DASH complex|condensed nuclear chromosome, centromeric region|mitotic spindle
YOR117W YOR117W RPT5 het Verified -0.478556451500491 0.316127102635847 no 738 0.353339489232822 2188 NA FF|FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS NUCLEUS One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription; similar to human TBP1 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|proteasome regulatory particle assembly|ubiquitin-dependent protein catabolic process ATPase activity proteasome regulatory particle, base subcomplex
YNL161W YNL161W CBK1 het Verified -0.480506907081706 0.315433496491073 no 739 0.297038629886961 2362 NA FT CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION NUCLEUS|SITE OF POLARIZED GROWTH Serine/threonine protein kinase of the the RAM signaling network; Ndr/LATS family member; binds regulatory subunit Mob2p; involved in regulation of cellular morphogenesis, polarized growth, and septum destruction; phosphorylation by Cbk1p regulates localization and activity of Ace2p transcription factor and Ssd1p translational repressor; Cbk1p activity is regulated by both phosphorylation and specific localization; relocalizes to cytoplasm upon DNA replication stress regulation of fungal-type cell wall organization|establishment or maintenance of cell polarity|protein phosphorylation|establishment or maintenance of actin cytoskeleton polarity|budding cell apical bud growth|Unknown protein serine/threonine kinase activity incipient cellular bud site|cellular bud|cellular bud neck|cellular bud tip|cytoplasm|cell cortex|nucleus|mating projection tip
YNL102W YNL102W POL1 het Verified -0.481661360200903 0.315023264646992 no 740 0.295594672524874 2359 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION|CHROMOSOME Catalytic subunit of the DNA polymerase I alpha-primase complex, required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis RNA-dependent DNA replication|lagging strand elongation|DNA synthesis involved in DNA repair|DNA replication|DNA replication initiation|premeiotic DNA replication DNA-directed DNA polymerase activity mitochondrion|alpha DNA polymerase:primase complex|replication fork
YNR043W YNR043W MVD1 het Verified -0.483196513599834 0.314478105294915 no 741 0.292756689042666 2383 NA FT LIPID METABOLISM Mevalonate pyrophosphate decarboxylase, essential enzyme involved in the biosynthesis of isoprenoids and sterols, including ergosterol; acts as a homodimer sterol biosynthetic process diphosphomevalonate decarboxylase activity cytoplasm
YNL182C YNL182C IPI3 het Verified -0.492414974901281 0.311213007603586 no 742 0.297217635420757 2362 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; highly conserved protein which contains several WD40 motifs; IPI3 is an essential gene ribosomal large subunit assembly|rRNA processing molecular_function nucleoplasm|nucleus
YJL054W YJL054W TIM54 het Verified -0.504402864523392 0.306989152752993 no 743 0.303823181798736 2362 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane protein import into mitochondrial inner membrane protein channel activity mitochondrion|integral to membrane|mitochondrial inner membrane protein insertion complex
YDR292C YDR292C SRP101 het Verified -0.505565820778672 0.306580740385031 no 744 0.280262914129505 2464 NA FT PROTEIN LOCALIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Signal recognition particle (SRP) receptor alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with the beta subunit, Srp102p SRP-dependent cotranslational protein targeting to membrane|protein targeting to ER GTP binding|signal recognition particle binding endoplasmic reticulum membrane|signal recognition particle receptor complex
YGR179C YGR179C OKP1 het Verified -0.508969113588875 0.305386936915202 no 745 0.298851857957043 2363 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME KINETOCHORE Outer kinetochore protein required for accurate chromosome segregation; component of COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) a kinetochore sub-complex which functions as a platform for kinetochore assembly; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-Q and fission yeast fta7 attachment of spindle microtubules to kinetochore|chromosome segregation molecular_function COMA complex|condensed nuclear chromosome kinetochore
YKL089W YKL089W MIF2 het Verified -0.509839025964904 0.305082121109129 no 746 0.316212859718983 2325 NA FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME KINETOCHORE Protein required for structural integrity of elongating spindles; localizes to the kinetochore; interacts with histones H2A, H2B, and H4; phosphorylated by Ipl1p; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-C and fission yeast cnp3 chromosome segregation|mitotic spindle organization in nucleus centromeric DNA binding condensed nuclear chromosome, centromeric region|condensed nuclear chromosome inner kinetochore
YMR185W YMR185W RTP1 het Verified -0.510289311495535 0.304924394907853 no 747 0.294741849793169 2398 NA Protein required for the nuclear import and biogenesis of RNA pol II; conflicting evidence on whether null mutant is viable with elongated buds, or inviable; interacts with Rpb2, Rpb3, Nup116p, Nup100p and components of the R2TP complex (Rvb1p, Rvb2p, Pih1p); similar to human TMCO7 gene biological_process molecular_function cellular_component
YBR079C YBR079C RPG1 het Verified -0.51508450960187 0.303246983378164 no 748 0.285308659681489 2419 NA FT TRANSLATION eIF3a subunit of the core complex of translation initiation factor 3 (eIF3), essential for translation; part of a Prt1p-Rpg1p-Nip1p subcomplex that stimulates binding of mRNA and tRNA(i)Met to ribosomes; involved in translation reinitiation translation reinitiation|translational initiation translation initiation factor activity incipient cellular bud site|eukaryotic translation initiation factor 3 complex|cytoplasmic stress granule|cytoplasm
YDR527W YDR527W RBA50 het Verified -0.516076567930523 0.30290046644198 no 749 0.302213677441898 2374 NA FF|FT TRANSCRIPTION FROM RNA POL II Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1 transcription from RNA polymerase II promoter molecular_function cytoplasm
YGR156W YGR156W PTI1 het Verified -0.516384894455134 0.302792806912119 no 750 0.296407029107102 2378 NA FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64 termination of RNA polymerase II transcription, exosome-dependent|mRNA cleavage|termination of RNA polymerase II transcription, poly(A)-coupled|mRNA polyadenylation|snoRNA 3'-end processing RNA binding mRNA cleavage and polyadenylation specificity factor complex|nucleus
YFR028C YFR028C CDC14 het Verified -0.519653892793896 0.301652414169105 no 751 0.308031226283238 2321 NA FT CELL CYCLE NUCLEUS|CYTOSKELETON Protein phosphatase required for mitotic exit; located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit; required for meiosis I spindle disassembly; released from nucleolus upon entry into anaphase I of meiosis, resequestered in metaphase II, then released again upon entry into anaphase II; maintained in nucleolus by Cdc55p in early meiosis regulation of exit from mitosis|mitotic cell cycle|protein dephosphorylation phosphoprotein phosphatase activity nucleolus|RENT complex|nucleus|spindle pole body
YNR026C YNR026C SEC12 het Verified -0.520160368514391 0.301475902650857 no 752 0.289730730410836 2435 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Guanine nucleotide exchange factor (GEF), activates Sar1p by catalyzing the exchange of GDP for GTP; required for the initiation of COPII vesicle formation in ER to Golgi transport; glycosylated integral membrane protein of the ER regulation of COPII vesicle coating Sar guanyl-nucleotide exchange factor activity Golgi apparatus|endoplasmic reticulum
YKL088W YKL088W CAB3 het Verified -0.522617317138707 0.300620293576226 no 753 0.299571597151321 2334 NA FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM Subunit of a phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaBC response to salt stress|coenzyme A biosynthetic process phosphopantothenoylcysteine decarboxylase activity|purine nucleotide binding phosphopantothenoylcysteine decarboxylase complex|cytoplasm
YJL087C YJL087C TRL1 het Verified -0.523001446732202 0.300486623236685 no 754 0.266185827335986 2474 NA FT RNA PROCESSING|SIGNALING|TRANSLATION ENDOMEMBRANE SYSTEM|NUCLEUS tRNA ligase, required for tRNA splicing and for both splicing and translation of HAC1 mRNA in the UPR; has phosphodiesterase, polynucleotide kinase, and ligase activities; localized at the inner nuclear envelope and partially to polysomes UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response|tRNA splicing, via endonucleolytic cleavage and ligation|positive regulation of translation in response to stress GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity|RNA ligase (ATP) activity|2',3'-cyclic-nucleotide 3'-phosphodiesterase activity nuclear inner membrane|polysome
YGL097W YGL097W SRM1 het Verified -0.525029166062674 0.299781457911041 no 755 0.296111548973075 2372 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RIBOSOME BIOGENESIS|CELL DIVISION|RNA LOCALIZATION NUCLEUS|CHROMOSOME Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p ribosomal subunit export from nucleus|rRNA export from nucleus signal transducer activity nuclear chromatin|integral to membrane|nucleus
YDL102W YDL102W POL3 het Verified -0.527184471656452 0.299032745509102 no 756 0.298002625817459 2348 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER) lagging strand elongation|RNA-dependent DNA replication|base-excision repair|postreplication repair|DNA replication, removal of RNA primer|nucleotide-excision repair|mismatch repair|maintenance of fidelity involved in DNA-dependent DNA replication|DNA replication|leading strand elongation single-stranded DNA specific 3'-5' exodeoxyribonuclease activity|DNA-directed DNA polymerase activity delta DNA polymerase complex|replication fork
YKR068C YKR068C BET3 het Verified -0.527229814915433 0.29901700324145 no 757 0.289397520999933 2390 NA FT VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Hydrophilic protein that acts in conjunction with SNARE proteins in targeting and fusion of ER to Golgi transport vesicles; component of the TRAPP (transport protein particle) complex ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport Rab guanyl-nucleotide exchange factor activity TRAPP complex|cis-Golgi network membrane
YLR397C YLR397C AFG2 het Verified -0.529915925784284 0.298085111860996 no 758 0.277549659223966 2437 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex; is essential for pre-60S maturation and release of several preribosome maturation factors; releases Rlp24p from purified pre-60S particles in vitro; may be involved in degradation of aberrant mRNAs ribosomal large subunit biogenesis|response to drug ATPase activity intracellular|preribosome, large subunit precursor
YKL035W YKL035W UGP1 het Verified -0.530248635863648 0.297969777046417 no 759 0.29877344453445 2350 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY UDP-glucose pyrophosphorylase (UGPase); catalyses the reversible formation of UDP-Glc from glucose 1-phosphate and UTP, involved in a wide variety of metabolic pathways, expression modulated by Pho85p through Pho4p; UGP1 has a paralog, YHL012W, that arose from the whole genome duplication (1->6)-beta-D-glucan biosynthetic process|UDP-glucose metabolic process|trehalose biosynthetic process|glycogen biosynthetic process UTP:glucose-1-phosphate uridylyltransferase activity plasma membrane|cytoplasm
YMR094W YMR094W CTF13 het Verified -0.535669780754988 0.296093396164094 no 760 0.256242180196872 2503 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION NUCLEUS|CHROMOSOME KINETOCHORE Subunit of the CBF3 complex, which binds to the CDE III element of centromeres, bending the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis kinetochore assembly|septin ring assembly DNA binding, bending|centromeric DNA binding condensed nuclear chromosome kinetochore|CBF3 complex
YJL002C YJL002C OST1 het Verified -0.539933932212811 0.294621297984405 no 761 0.28516084454229 2398 NA FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Alpha subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins protein N-linked glycosylation via asparagine|protein N-linked glycosylation dolichyl-diphosphooligosaccharide-protein glycotransferase activity oligosaccharyltransferase complex
YPL190C YPL190C NAB3 het Verified -0.542147417653341 0.293858477680468 no 762 0.285011038005569 2427 NA FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3′ end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; required for termination of non-poly(A) transcripts and efficient splicing nuclear mRNA surveillance|mRNA 3'-end processing|antisense RNA transcript catabolic process|CUT catabolic process|termination of RNA polymerase II transcription, exosome-dependent|tRNA 3'-end processing|snRNA 3'-end processing|snoRNA 3'-end processing RNA binding|transcription regulatory region RNA binding Nrd1 complex|nucleus
YKL186C YKL186C MTR2 het Verified -0.548667226657912 0.291616920642337 no 763 0.278895448189827 2452 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE mRNA transport regulator, essential nuclear protein; Mex67p and Mtr2p form a mRNA export complex which binds to RNA poly(A)+ mRNA export from nucleus|ribosomal large subunit export from nucleus protein binding integral to membrane|nuclear RNA export factor complex|nuclear pore
YIR006C YIR006C PAN1 het Verified -0.553144724249392 0.290082156823694 no 764 0.268597705354574 2471 NA FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION|CYTOSKELETON ORGANIZATION NUCLEUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p, associates with actin patches on the cell cortex; promotes protein-protein interactions essential for endocytosis; binds to and activates the Arp2/3 complex in vitro; previously thought to be a subunit of poly(A) ribonuclease bipolar cellular bud site selection|endocytosis|axial cellular bud site selection|cytokinesis|actin cortical patch assembly protein binding, bridging nucleus|plasma membrane|mating projection tip|cytoplasm|actin cortical patch
YGL122C YGL122C NAB2 het Verified -0.556578401901735 0.288907756871322 no 765 0.26156922303402 2490 NA FT RNA PROCESSING|RNA LOCALIZATION NUCLEUS Nuclear polyadenylated RNA-binding protein; required for nuclear mRNA export and poly(A) tail length control; binds nuclear pore protein Mlp1p; autoregulates mRNA levels; related to human hnRNPs; nuclear localization sequence binds Kap104p; protein abundance increases in response to DNA replication stress poly(A)+ mRNA export from nucleus|mRNA polyadenylation|regulation of mRNA stability poly(A) RNA binding nucleus|cytoplasm
YKL014C YKL014C URB1 het Verified -0.558048416884701 0.288405661462628 no 766 0.2613422413585 2494 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs, associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function nucleolus
YGR140W YGR140W CBF2 het Verified -0.561436596598156 0.287249970823868 no 767 0.262579529536336 2463 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME|CYTOSKELETON KINETOCHORE Essential kinetochore protein; component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo; relative distribution to the spindle pole body decreases upon DNA replication stress chromosome segregation|septin ring assembly|mitotic spindle elongation DNA binding, bending|centromeric DNA binding spindle midzone|condensed nuclear chromosome kinetochore|CBF3 complex|condensed nuclear chromosome, centromeric region|spindle
YPL146C YPL146C NOP53 het Verified -0.561457605821794 0.287242811528204 no 768 0.267567239135935 2489 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Nucleolar protein; involved in biogenesis of the 60S subunit of the ribosome; interacts with rRNA processing factors Cbf5p and Nop2p; null mutant is viable but growth is severely impaired ribosomal large subunit export from nucleus|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) rRNA binding nucleolus|nucleus
YGR030C YGR030C POP6 het Verified -0.56308606565268 0.286688139754158 no 769 0.293444083500949 2386 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs tRNA processing|intronic box C/D snoRNA processing|mRNA cleavage|rRNA processing ribonuclease MRP activity|ribonuclease P activity nucleolar ribonuclease P complex|ribonuclease MRP complex
YOR157C YOR157C PUP1 het Verified -0.575219852614517 0.282571308945117 no 770 0.30317811966403 2354 NA FF|FT PROTEOLYSIS ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Beta 2 subunit of the 20S proteasome; endopeptidase with trypsin-like activity that cleaves after basic residues; synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process endopeptidase activity proteasome storage granule|nucleus|endoplasmic reticulum membrane|proteasome core complex, beta-subunit complex
YMR117C YMR117C SPC24 het Verified -0.576867198899006 0.282014585126748 no 771 0.255090618082009 2530 NA FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME KINETOCHORE Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering microtubule nucleation|chromosome segregation structural constituent of cytoskeleton Ndc80 complex|condensed nuclear chromosome kinetochore|condensed nuclear chromosome, centromeric region
YBL077W_d YBL077W YBL077W het Dubious -0.589791576809376 0.277665195253424 no 772 0.261384459442133 2504 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ILS1/YBL076C Unknown Unknown Unknown
YKR008W YKR008W RSC4 het Verified -0.593114311832103 0.276552326525651 no 773 0.295820795730421 2375 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION NUCLEUS RSC COMPLEX Component of the RSC chromatin remodeling complex; found in close proximity to nucleosomal DNA; displaced from the surface of nucleosomal DNA after chromatin remodeling; acetylated (K25) by Gcn5p, altering replication stress tolerance; contains tandem bromodomains that recognize histone H3 acetylated on K14 (H3K14ac) by Gcn5p G2/M transition of mitotic cell cycle|ATP-dependent chromatin remodeling|nucleosome disassembly|transcription elongation from RNA polymerase II promoter histone acetyl-lysine binding|DNA translocase activity RSC complex
YDR232W YDR232W HEM1 het Verified -0.593651918312136 0.276372474120862 no 774 0.279582003257484 2451 NA FT COFACTOR METABOLISM MITOCHONDRION 5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p heme biosynthetic process 5-aminolevulinate synthase activity mitochondrion|mitochondrial matrix
YGR175C YGR175C ERG1 het Verified -0.595435155261084 0.275776316035966 no 775 0.287185741948111 2438 NA FT LIPID METABOLISM|OXIDATION-REDUCTION PROCESS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine ergosterol biosynthetic process drug binding|squalene monooxygenase activity endoplasmic reticulum|lipid particle
YDR160W YDR160W SSY1 het Verified -0.596029237927399 0.275577847314975 no 776 0.271689505814769 2472 NA FT PLASMA MEMBRANE Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes response to amino acid stimulus molecular_function integral to membrane|plasma membrane
YML031W YML031W NDC1 het Verified -0.597038813756227 0.275240733512008 no 777 0.28738543796274 2390 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CYTOSKELETON ORGANIZATION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON NUCLEAR PORE Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NDC1 nucleocytoplasmic transport|nuclear pore organization|spindle pole body duplication associated with nuclear envelope structural constituent of nuclear pore integral to membrane|nuclear pore transmembrane ring|spindle pole body|nuclear pore
YOR146W_d YOR146W YOR146W het Dubious -0.599905615502716 0.274284569877223 no 778 0.316510009457252 2333 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene PNO1/YOR145C Unknown Unknown Unknown
YFR052W YFR052W RPN12 het Verified -0.601542883132971 0.273739229232389 no 779 0.27079441619757 2452 NA FT PROTEOLYSIS Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p; protein abundance increases in response to DNA replication stress ubiquitin-dependent protein catabolic process molecular_function proteasome storage granule|proteasome regulatory particle, lid subcomplex
YDL017W YDL017W CDC7 het Verified -0.605324117079869 0.272481829994586 no 780 0.245507456928794 2539 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION|PROTEIN PHOSPHORYLATION|GENE SILENCING NUCLEUS DDK (Dbf4-dependent kinase) catalytic subunit required for origin firing and replication fork progression in mitotic S phase through phosphorylation of Mcm2-7p complexes and Cdc45p; kinase activity correlates with cyclical DBF4 expression; required for pre-meiotic DNA replication, meiotic DSB formation, recruitment of the monopolin complex to kinetochores during meiosis I and as a gene-specific regulator of the meiosis-specific transcription factor Ndt80p negative regulation of exit from mitosis|regulation of chromatin silencing at telomere|protein phosphorylation|double-strand break repair via break-induced replication|DNA replication initiation protein serine/threonine kinase activity nucleus|Dbf4-dependent protein kinase complex
YJR112W YJR112W NNF1 het Verified -0.606852679397382 0.27197434215824 no 781 0.245639994232953 2547 NA FT CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME KINETOCHORE Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation chromosome segregation molecular_function nuclear MIS12/MIND type complex|kinetochore
YLR005W YLR005W SSL1 het Verified -0.609957088792533 0.270945116790877 no 782 0.277206236859471 2464 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|TRANSLATION|PROTEIN PHOSPHORYLATION NUCLEUS RNA POL II, HOLOENZYME Component of the core form of RNA polymerase transcription factor TFIIH, which has both protein kinase and DNA-dependent ATPase/helicase activities and is essential for transcription and nucleotide excision repair; interacts with Tfb4p phosphorylation of RNA polymerase II C-terminal domain|translational initiation|nucleotide-excision repair|transcription from RNA polymerase II promoter core RNA polymerase binding transcription factor activity core TFIIH complex|holo TFIIH complex|nucleotide-excision repair factor 3 complex
YCR072C YCR072C RSA4 het Verified -0.610713458096298 0.270694647422084 no 783 0.229084547926126 2601 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS NUCLEUS WD-repeat protein involved in ribosome biogenesis; may interact with ribosomes; required for maturation and efficient intra-nuclear transport or pre-60S ribosomal subunits, localizes to the nucleolus ribosomal large subunit assembly molecular_function ribosome|nucleolus
YNL075W YNL075W IMP4 het Verified -0.614534625425913 0.269431049762107 no 784 0.280805464849202 2419 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs rRNA processing snoRNA binding|single-stranded telomeric DNA binding|rRNA primary transcript binding small-subunit processome|Mpp10 complex|90S preribosome
YNL189W YNL189W SRP1 het Verified -0.614934368840353 0.269299032182963 no 785 0.274554592803065 2463 NA FT PROTEIN LOCALIZATION NUCLEUS Karyopherin alpha homolog, forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during import; may also play a role in regulation of protein degradation protein targeting to membrane|protein import into nucleus protein transporter activity integral to membrane|nuclear exosome (RNase complex)|nucleus|cytoplasm
YMR239C YMR239C RNT1 het Verified -0.619895934094522 0.267663151401031 no 786 0.258672477869864 2469 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION NUCLEUS Nuclear dsRNA-specific ribonuclease (RNase III); involved in rDNA transcription, rRNA processing and U2 snRNA 3' end formation by cleavage of a stem-loop structure at the 3' end of U2 snRNA; involved in polyadenylation-independent transcription termination; involved in the cell wall stress response, regulating the degradation of cell wall integrity and morphogenesis checkpoint genes U5 snRNA 3'-end processing|mRNA cleavage|chromatin organization|termination of RNA polymerase II transcription, exosome-dependent|U4 snRNA 3'-end processing|U1 snRNA 3'-end processing|rRNA transcription|rRNA processing ribonuclease III activity nucleoplasm|nucleolus
YOR077W YOR077W RTS2 het Verified -0.620682414738474 0.26740430101548 no 787 0.244589700033971 2554 NA FT NUCLEUS Basic zinc-finger protein, similar to human and mouse Kin17 proteins which are chromatin-associated proteins involved in UV response and DNA replication biological_process molecular_function nucleus|cytoplasm
YDR170C YDR170C SEC7 het Verified -0.621483515863507 0.267140768538401 no 788 0.261751720379029 2473 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|RESPONSE TO NUTRIENT LEVELS GOLGI APPARATUS Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|autophagic vacuole assembly ARF guanyl-nucleotide exchange factor activity trans-Golgi network|cytosol|late endosome|integral to membrane|Golgi-associated vesicle
YOL102C YOL102C TPT1 het Verified -0.621568756716855 0.267112735187195 no 789 0.243746372302373 2536 NA FT RNA PROCESSING NUCLEUS tRNA 2'-phosphotransferase, catalyzes the final step in yeast tRNA splicing: the transfer of the 2'-PO(4) from the splice junction to NAD(+) to form ADP-ribose 1''-2''cyclic phosphate and nicotinamide tRNA splicing, via endonucleolytic cleavage and ligation tRNA 2'-phosphotransferase activity nucleus|cytoplasm
YLR314C YLR314C CDC3 het Verified -0.623679058442074 0.266419189371509 no 790 0.265325317643849 2443 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble with other septins into rod-like complexes that can associate with other rods to form filament polymers; septin rings at the mother-bud neck act as scaffolds for recruiting factors needed for cell division and as barriers to prevent diffusion of specific proteins between mother and daughter cells septin ring disassembly|maintenance of cell polarity|cell cycle cytokinesis|septin ring assembly structural molecule activity|GTP binding|1-phosphatidylinositol binding mating projection base|septin filament array|cellular bud neck septin ring|septin complex|prospore membrane|ascospore wall
YDR208W YDR208W MSS4 het Verified -0.624180416649653 0.266254553181168 no 791 0.237290317304427 2578 NA FT LIPID METABOLISM NUCLEUS|PLASMA MEMBRANE Phosphatidylinositol-4-phosphate 5-kinase, involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation phosphatidylinositol phosphorylation|ascospore-type prospore assembly 1-phosphatidylinositol-4-phosphate 5-kinase activity nucleus|plasma membrane
YGL001C YGL001C ERG26 het Verified -0.625609498097334 0.265785553666493 no 792 0.265329890313392 2501 NA FT LIPID METABOLISM|OXIDATION-REDUCTION PROCESS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis ergosterol biosynthetic process C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity endoplasmic reticulum|endoplasmic reticulum membrane
YKL104C YKL104C GFA1 het Verified -0.625834139674043 0.265711868338065 no 793 0.266072051308143 2487 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM Glutamine-fructose-6-phosphate amidotransferase; catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis; GFA1 has a paralogous region, comprising ORFs YMR084W-YMR085W, that arose from the whole genome duplication fungal-type cell wall chitin biosynthetic process glutamine-fructose-6-phosphate transaminase (isomerizing) activity cellular_component
YER136W YER136W GDI1 het Verified -0.627952616486173 0.265017490446862 no 794 0.24100513145545 2560 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins vesicle-mediated transport Rab GDP-dissociation inhibitor activity cellular_component
YGL044C YGL044C RNA15 het Verified -0.632274280969068 0.263603833192878 no 795 0.265515041240987 2477 NA FT RNA PROCESSING NUCLEUS Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; interacts with the A-rich polyadenylation signal in complex with Rna14p and Hrp1p; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping mRNA cleavage|mRNA polyadenylation mRNA binding|protein heterodimerization activity mRNA cleavage factor complex
YGR158C YGR158C MTR3 het Verified -0.633925313740357 0.263064782285047 no 796 0.269755520746796 2469 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6) nuclear mRNA surveillance|nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear polyadenylation-dependent mRNA catabolic process|nonfunctional rRNA decay|U4 snRNA 3'-end processing|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|polyadenylation-dependent snoRNA 3'-end processing|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|nuclear-transcribed mRNA catabolic process, non-stop decay molecular_function nucleolus|nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)
YDL132W YDL132W CDC53 het Verified -0.637359159985805 0.261945461975465 no 797 0.28640343436979 2405 NA FT CELL CYCLE|CELL DIVISION|PROTEOLYSIS NUCLEUS UBIQUITIN LIGASE COMPLEX Cullin, structural protein of SCF complexes (which also contain Skp1p, Cdc34p, Hrt1p and an F-box protein) involved in ubiquitination; SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|G2/M transition of mitotic cell cycle|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|G1/S transition of mitotic cell cycle ubiquitin-protein ligase activity|DNA replication origin binding|protein binding, bridging SCF ubiquitin ligase complex
YBR190W_d YBR190W YBR190W het Dubious -0.637389391061076 0.261935618499856 no 798 0.290768848781689 2382 NA Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified ribosomal protein gene RPL21A/YBR191W Unknown Unknown Unknown
YMR229C YMR229C RRP5 het Verified -0.638250418711721 0.261655340784713 no 799 0.250288837749845 2514 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS RNA binding protein involved in synthesis of both 18S and 5.8S rRNAs; component of both the ribosomal small subunit (SSU) processosome and the 90S preribosome; has binding preference for single stranded tracts of U's; relocalizes from nucleolus to nucleus upon DNA replication stress endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) poly(U) RNA binding small-subunit processome|nucleolus|90S preribosome
YDR087C YDR087C RRP1 het Verified -0.638538440129477 0.261561619756418 no 800 0.261160025205154 2491 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Essential evolutionarily conserved nucleolar protein necessary for biogenesis of 60S ribosomal subunits and processing of pre-rRNAs to mature rRNAs, associated with several distinct 66S pre-ribosomal particles rRNA processing molecular_function nucleolus|nucleus|preribosome, large subunit precursor
YLR075W YLR075W RPL10 het Verified -0.640994007012234 0.260763288331222 no 801 0.313582758005547 2327 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal 60S subunit protein L10; responsible for joining the 40S and 60S subunits; regulates translation initiation; similar to members of the QM gene family; homologous to mammalian ribosomal protein L10 and bacterial L16; protein abundance increases in response to DNA replication stress; mutations in the human ortholog are associated with development of T-cell acute lymphoblastic leukemia and similar changes in the yeast gene result in ribosome biogenesis defects cytoplasmic translation|translational termination|ribosomal large subunit assembly structural constituent of ribosome cytosolic large ribosomal subunit
YER133W YER133W GLC7 het Verified -0.641698380963472 0.260534520333364 no 802 0.358774303457598 2181 NA FF|FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|CELL DIVISION|CARBOHYDRATE METABOLISM NUCLEUS|SITE OF POLARIZED GROWTH|CHROMOSOME|CYTOSKELETON KINETOCHORE Type 1 serine/threonine protein phosphatase catalytic subunit; involved in various processes including glycogen metabolism, sporulation, mitosis; accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; import into nucleus is inhibited during spindle assembly checkpoint arrest replication fork processing|glycogen metabolic process|chromosome segregation|regulation of cell shape during vegetative growth phase|termination of RNA polymerase II transcription, poly(A)-coupled|protein dephosphorylation|mitotic cell cycle spindle assembly checkpoint|rRNA processing|regulation of cell cycle|ascospore formation|protein localization to kinetochore|cell budding|DNA damage checkpoint|meiosis|termination of RNA polymerase II transcription, exosome-dependent|DNA replication checkpoint|response to heat|cellular ion homeostasis|histone dephosphorylation|regulation of carbohydrate metabolic process protein serine/threonine phosphatase activity protein phosphatase type 1 complex|mating projection base|condensed nuclear chromosome kinetochore|mRNA cleavage and polyadenylation specificity factor complex|nucleolus|spindle pole body|cellular bud neck
YMR218C YMR218C TRS130 het Verified -0.642278679524653 0.260346127456318 no 803 0.244241952238493 2537 NA FT VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM GOLGI APPARATUS One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in ER to Golgi membrane traffic; mutation activates transcription of OCH1; mutants are defective in cytoplasm-to-vacuole targeting (Cvt) pathway and starvation-induced autophagy regulation of Rab GTPase activity|early endosome to Golgi transport|intra-Golgi vesicle-mediated transport Rab guanyl-nucleotide exchange factor activity TRAPP complex|trans-Golgi network|early endosome
YMR005W YMR005W TAF4 het Verified -0.643920187539188 0.259813595142149 no 804 0.26103547190118 2460 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME TFIID subunit (48 kDa), involved in RNA polymerase II transcription initiation; potential Cdc28p substrate RNA polymerase II transcriptional preinitiation complex assembly|transcription from RNA polymerase II promoter chromatin binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly|RNA polymerase II activating transcription factor binding transcription factor TFIID complex
YNL317W YNL317W PFS2 het Verified -0.643935168729526 0.259808737585928 no 805 0.266911572370049 2481 NA FT RNA PROCESSING NUCLEUS Integral subunit of the pre-mRNA cleavage and polyadenylation factor (CPF) complex; plays an essential role in mRNA 3'-end formation by bridging different processing factors and thereby promoting the assembly of the processing complex mRNA cleavage|mRNA polyadenylation RNA binding mRNA cleavage and polyadenylation specificity factor complex
YLR243W YLR243W GPN3 het Verified -0.650758576551805 0.257601171961977 no 806 0.240294128037338 2547 NA FT PROTEIN LOCALIZATION Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn2p biological_process signal sequence binding cellular_component
YLR272C YLR272C YCS4 het Verified -0.652150101609299 0.257152172975367 no 807 0.255152276588281 2496 NA FT CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION|GENE SILENCING NUCLEUS|CHROMOSOME Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation, chromatin binding of condensin, tRNA gene clustering at the nucleolus, and silencing at the mating type locus; required for replication slow zone (RSZ) breakage following Mec1p inactivation maintenance of rDNA|meiotic chromosome condensation|mitotic chromosome condensation|tRNA gene clustering|mitotic sister chromatid segregation|chromatin silencing at silent mating-type cassette molecular_function nucleolus|nuclear condensin complex
YKL192C YKL192C ACP1 het Verified -0.65402778681404 0.256546951890304 no 808 0.232527700376437 2581 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Mitochondrial matrix acyl carrier protein, involved in biosynthesis of octanoate, which is a precursor to lipoic acid; activated by phosphopantetheinylation catalyzed by Ppt2p lipoate biosynthetic process ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process mitochondrion
YJL143W YJL143W TIM17 het Verified -0.657129824827731 0.255548721550502 no 809 0.24512632628438 2557 NA FT PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Essential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); with Tim23p, contributes to the architecture and function of the import channel; may link the import motor to the core TIM23 complex protein import into mitochondrial matrix|mitochondrial genome maintenance protein channel activity mitochondrion|integral to membrane|mitochondrial inner membrane presequence translocase complex
YIL129C YIL129C TAO3 het Verified -0.657354818456741 0.255476397999421 no 810 0.257659247606804 2492 NA FT CELL DIVISION MITOCHONDRION|SITE OF POLARIZED GROWTH Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p cell morphogenesis|cell budding|budding cell apical bud growth molecular_function incipient cellular bud site|mitochondrion|cellular bud|mating projection tip
YKL058W YKL058W TOA2 het Verified -0.65865421956579 0.255058918597925 no 811 0.262669913727175 2479 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA; protein abundance increases in response to DNA replication stress transcription initiation from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly TBP-class protein binding|TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly|TBP-class protein binding RNA polymerase II transcription factor activity transcription factor TFIIA complex
YPL124W YPL124W SPC29 het Verified -0.664661620536796 0.253133473377987 no 812 0.247504287264059 2537 NA FT CELL CYCLE|CYTOSKELETON ORGANIZATION NUCLEUS|CYTOSKELETON Inner plaque spindle pole body (SPB) component, links the central plaque component Spc42p to the inner plaque component Spc110p; required for SPB duplication microtubule nucleation|spindle pole body duplication associated with nuclear envelope structural constituent of cytoskeleton central plaque of spindle pole body
YOR224C YOR224C RPB8 het Verified -0.665587601323937 0.252837366767796 no 813 0.321484226917751 2301 NA FF|FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III tRNA transcription from RNA polymerase III promoter|transcription from RNA polymerase I promoter|transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter RNA-directed RNA polymerase activity|DNA-directed RNA polymerase activity DNA-directed RNA polymerase III complex|DNA-directed RNA polymerase I complex|DNA-directed RNA polymerase II, core complex
YOL146W YOL146W PSF3 het Verified -0.666671910023661 0.252490862569917 no 814 0.246106942725881 2532 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery double-strand break repair via break-induced replication|DNA-dependent DNA replication molecular_function replication fork protection complex|GINS complex|DNA replication preinitiation complex
YMR001C YMR001C CDC5 het Verified -0.668794865527169 0.251813171234764 no 815 0.270041241259362 2466 NA FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|CHROMOSOME SEGREGATION NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON Polo-like kinase with multiple functions in mitosis and cytokinesis through substrate phosphorylation, also functions in adaptation to DNA damage during meiosis; has similarity to Xenopus Plx1 and S. pombe Plo1p; possible Cdc28p substrate synaptonemal complex disassembly|spindle assembly involved in meiosis|protein phosphorylation|resolution of meiotic recombination intermediates|positive regulation of spindle pole body separation protein kinase activity nucleus|cellular bud neck|spindle pole
YNL158W YNL158W PGA1 het Verified -0.669763531842169 0.251504272249557 no 816 0.23280195383968 2568 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Essential component of GPI-mannosyltransferase II, responsible for second mannose addition to GPI precursors as a partner of Gpi18p; required for maturation of Gas1p and Pho8p; has synthetic genetic interations with secretory pathway genes GPI anchor biosynthetic process mannosyltransferase activity integral to endoplasmic reticulum membrane|nuclear envelope|mannosyltransferase complex
YDL120W YDL120W YFH1 het Verified -0.670091348610173 0.25139977979173 no 817 0.234596793650423 2597 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|COFACTOR METABOLISM MITOCHONDRION Mitochondrial matrix iron chaperone; oxidizes and stores iron; interacts with Isu1p to promote Fe-S cluster assembly; mutation results in multiple Fe/S-dependent enzyme deficiencies; human frataxin homolog is mutated in Friedrich's ataxia cellular iron ion homeostasis|iron-sulfur cluster assembly|glutathione metabolic process ferrous iron binding|ferroxidase activity|iron chaperone activity mitochondrion|mitochondrial matrix
YGR216C YGR216C GPI1 het Verified -0.672407373857374 0.250662194868767 no 818 0.214828513068081 2611 NA FT LIPID METABOLISM ENDOPLASMIC RETICULUM Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs GPI anchor biosynthetic process phosphatidylinositol N-acetylglucosaminyltransferase activity glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|integral to membrane
YPL210C YPL210C SRP72 het Verified -0.672445447525489 0.25065007912499 no 819 0.257863546930568 2521 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition|protein targeting to ER signal sequence binding signal recognition particle, endoplasmic reticulum targeting
YML064C YML064C TEM1 het Verified -0.67673401167131 0.249287366382647 no 820 0.244041607915766 2543 NA FT CELL CYCLE|SIGNALING|CELL DIVISION CYTOSKELETON GTP-binding protein of the ras superfamily involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis regulation of exit from mitosis protein binding|GTPase activity spindle pole body
YEL035C_p YEL035C UTR5 het Uncharacterized -0.677443611430246 0.249062267920202 no 821 0.27223669643009 2463 NA Protein of unknown function; transcription may be regulated by Gcr1p; essential for growth under standard (aerobic) conditions but not under anaerobic conditions biological_process molecular_function cellular_component
YHR188C YHR188C GPI16 het Verified -0.67980985507869 0.248312432878691 no 822 0.218556765484699 2629 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Tp homolog attachment of GPI anchor to protein GPI-anchor transamidase activity GPI-anchor transamidase complex
YER165W YER165W PAB1 het Verified -0.681586252299979 0.247750305186007 no 823 0.263707462322523 2488 NA FF|FT RNA PROCESSING|TRANSLATION|RNA LOCALIZATION NUCLEUS RIBOSOME Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G regulation of nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation poly(A) RNA binding ribosome|nucleus|cytoplasmic stress granule|cytoplasm
YPR169W YPR169W JIP5 het Verified -0.682844724248513 0.247352482668457 no 824 0.269016499232803 2435 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS NUCLEUS Essential protein required for biogenesis of the large ribosomal subunit; interacts with proteins involved in RNA processing, ribosome biogenesis, ubiquitination and demethylation; similar to WDR55, a human WD repeat protein ribosomal large subunit biogenesis molecular_function nucleolus|nucleus
YBL023C YBL023C MCM2 het Verified -0.683273062837859 0.247217156122571 no 825 0.281889670855444 2440 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex; relative distribution to the nucleus increases upon DNA replication stress S phase of mitotic cell cycle|DNA strand elongation involved in DNA replication|pre-replicative complex assembly|double-strand break repair via break-induced replication chromatin binding|DNA replication origin binding|DNA helicase activity|single-stranded DNA binding replication fork protection complex|nucleus|DNA replication preinitiation complex|pre-replicative complex|cytoplasm|MCM complex
YBR135W YBR135W CKS1 het Verified -0.696877318544527 0.242939786670918 no 826 0.215941501548692 2623 NA FT CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION NUCLEUS Cyclin-dependent protein kinase regulatory subunit and adaptor; modulates proteolysis of M-phase targets through interactions with the proteasome; role in transcriptional regulation, recruiting proteasomal subunits to target gene promoters positive regulation of transcription, DNA-dependent|regulation of cell cycle|transcription, DNA-dependent|chromatin remodeling ubiquitin binding|protein kinase activator activity|histone binding cyclin-dependent protein kinase holoenzyme complex|nucleus|cytoplasm
YGR083C YGR083C GCD2 het Verified -0.699815251908 0.242021344271547 no 827 0.278573224067721 2433 NA FT TRANSLATION Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression regulation of translational initiation enzyme regulator activity|guanyl-nucleotide exchange factor activity|translation initiation factor activity eukaryotic translation initiation factor 2B complex|guanyl-nucleotide exchange factor complex
YML077W YML077W BET5 het Verified -0.700127599978591 0.24192381040733 no 828 0.223002105755056 2626 NA FT VESICLE-MEDIATED TRANSPORT ENDOPLASMIC RETICULUM|GOLGI APPARATUS Component of the TRAPP (transport protein particle) complex, which plays an essential role in the vesicular transport from endoplasmic reticulum to Golgi ER to Golgi vesicle-mediated transport Rab guanyl-nucleotide exchange factor activity TRAPP complex
YKL095W YKL095W YJU2 het Verified -0.701556733828752 0.24147782091471 no 829 0.228812833038229 2622 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING NUCLEUS Essential protein required for pre-mRNA splicing; associates transiently with the spliceosomal NTC (nineteen complex) and acts after Prp2p to promote the first catalytic reaction of splicing generation of catalytic spliceosome for first transesterification step first spliceosomal transesterification activity nucleus|U2-type catalytic step 1 spliceosome
YPR190C YPR190C RPC82 het Verified -0.702034273225772 0.241328894896441 no 830 0.26379319754182 2548 NA FT NUCLEUS RNA polymerase III subunit C82 tRNA transcription from RNA polymerase III promoter DNA-directed RNA polymerase activity DNA-directed RNA polymerase III complex
YER036C YER036C ARB1 het Verified -0.706387945447536 0.239973457636537 no 831 0.206520638884741 2657 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|NUCLEOTIDE METABOLISM NUCLEUS ATPase of the ATP-binding cassette (ABC) family involved in 40S and 60S ribosome biogenesis, has similarity to Gcn20p; shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p ribosomal small subunit export from nucleus|ribosome biogenesis ATPase activity, uncoupled ribosome|nucleus|cytoplasm
YEL058W YEL058W PCM1 het Verified -0.707651527777763 0.239580842802707 no 832 0.177745000664382 2745 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM NUCLEUS Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors fungal-type cell wall chitin biosynthetic process phosphoacetylglucosamine mutase activity nucleus|cytoplasm
YNL267W YNL267W PIK1 het Verified -0.708533837789515 0.239306903294674 no 833 0.269524280610389 2456 NA FF|FT LIPID METABOLISM|SIGNALING NUCLEUS|GOLGI APPARATUS Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton phosphatidylinositol phosphorylation 1-phosphatidylinositol 4-kinase activity trans-Golgi network|nucleus
YBL073W_d YBL073W YBL073W het Dubious -0.708674305903594 0.239263306565961 no 834 0.222716018389022 2656 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene AAR2/YBL074C Unknown Unknown Unknown
YNL114C_d YNL114C YNL114C het Dubious -0.709506597023528 0.239005079550827 no 835 0.262362821705503 2479 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPC19/YNL113W, an RNA polymerase subunit Unknown Unknown Unknown
YJL050W YJL050W MTR4 het Verified -0.709537586486242 0.238995467689394 no 836 0.252329972481137 2533 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|OXIDATION-REDUCTION PROCESS|RNA LOCALIZATION NUCLEUS ATP-dependent 3'-5' RNA helicase of the DExD/H family; involved in nuclear RNA processing and degradation both as a component of TRAMP complex and in TRAMP-independent processes; TRAMP unwinds RNA duplexes, with Mtr4p unwinding activity stimulated by Pap2p/Air2p but not dependent on ongoing polyadenylation; contains an arch domain, with two coiled-coil arms/stalks and a globular fist/KOW domain, which has RNA binding activity and is required for 5.8S rRNA processing U5 snRNA 3'-end processing|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|ncRNA polyadenylation|nuclear polyadenylation-dependent mRNA catabolic process|U4 snRNA 3'-end processing|nuclear mRNA surveillance of mRNA 3'-end processing|nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription|rRNA catabolic process|polyadenylation-dependent snoRNA 3'-end processing|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ATP-dependent 3'-5' RNA helicase activity|poly(A) RNA binding nucleolus|nucleus|TRAMP complex
YGR116W YGR116W SPT6 het Verified -0.710246978955325 0.238775496439339 no 837 0.24580668942874 2536 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|RNA LOCALIZATION NUCLEUS|MITOCHONDRION|CHROMOSOME Nucleosome remodeling protein; functions in various aspects of transcription, chromatin maintenance, and RNA processing; required for the maintenance of chromatin structure during transcription in order to inhibit transcription from promoters within the coding region poly(A)+ mRNA export from nucleus|regulation of transcription by chromatin organization|regulation of mRNA 3'-end processing|transcription antitermination|positive regulation of transcription involved in G1/S phase of mitotic cell cycle|regulation of transcriptional start site selection at RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter by glucose|negative regulation of transcription from RNA polymerase II promoter|nucleosome organization|chromatin maintenance|regulation of nucleosome density|nucleosome assembly|chromatin remodeling|regulation of histone H3-K36 methylation|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter in response to stress core RNA polymerase II binding transcription factor activity|nucleosome binding|histone binding|DNA binding transcription antitermination factor activity mitochondrion|nucleus|transcriptionally active chromatin
YPR103W YPR103W PRE2 het Verified -0.710991776202145 0.238544665971671 no 838 0.255295010562767 2495 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Beta 5 subunit of the 20S proteasome, responsible for the chymotryptic activity of the proteasome proteasomal ubiquitin-dependent protein catabolic process|proteasome core complex assembly|proteasomal ubiquitin-independent protein catabolic process endopeptidase activity nucleus|proteasome storage granule|endoplasmic reticulum membrane|proteasome core complex, beta-subunit complex
YDR037W YDR037W KRS1 het Verified -0.712949041927164 0.237938645239861 no 839 0.192029313735134 2768 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION Lysyl-tRNA synthetase lysyl-tRNA aminoacylation lysine-tRNA ligase activity cytoplasm
YNL287W YNL287W SEC21 het Verified -0.713541844204147 0.23775526481057 no 840 0.255244988594465 2520 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo retrograde vesicle-mediated transport, Golgi to ER|ER to Golgi vesicle-mediated transport molecular_function endosome|COPI vesicle coat
YHR122W YHR122W CIA2 het Verified -0.71556917731868 0.237128705734279 no 841 0.232880486230092 2587 NA FT CELL CYCLE|CHROMOSOME SEGREGATION NUCLEUS Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human FAM96B establishment of mitotic sister chromatid cohesion molecular_function nucleus|cytoplasm
YLR101C_d YLR101C YLR101C het Dubious -0.716778668440308 0.236755337975385 no 842 0.198502198273105 2673 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF ERG27/YLR100W Unknown Unknown Unknown
YMR197C YMR197C VTI1 het Verified -0.717269323961678 0.236603965722779 no 843 0.215543883808175 2657 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Protein involved in cis-Golgi membrane traffic; v-SNARE that interacts with two t-SNARES, Sed5p and Pep12p; required for multiple vacuolar sorting pathways Golgi to vacuole transport|vacuole fusion, non-autophagic|intra-Golgi vesicle-mediated transport|vesicle fusion SNAP receptor activity SNARE complex|integral to Golgi membrane
YDL097C YDL097C RPN6 het Verified -0.71870431824334 0.23616156104187 no 844 0.282923567051508 2413 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS Essential, non-ATPase regulatory subunit of the 26S proteasome lid; required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion; protein abundance increases in response to DNA replication stress proteasome assembly|ubiquitin-dependent protein catabolic process structural molecule activity proteasome storage granule|proteasome regulatory particle, lid subcomplex
YJL034W YJL034W KAR2 het Verified -0.719545682412413 0.235902382894001 no 845 0.208658759192217 2669 NA FT PROTEIN LOCALIZATION|PROTEOLYSIS ENDOPLASMIC RETICULUM ATPase involved in protein import into the ER, also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins; regulates the unfolded protein response via interaction with Ire1p karyogamy involved in conjugation with cellular fusion|posttranslational protein targeting to membrane, translocation|ER-associated protein catabolic process|SRP-dependent cotranslational protein targeting to membrane, translocation|response to unfolded protein unfolded protein binding|ATPase activity endoplasmic reticulum|luminal surveillance complex
YGR211W YGR211W ZPR1 het Verified -0.720008926556889 0.235759749736292 no 846 0.212467552104009 2667 NA FT CELL CYCLE|RESPONSE TO NUTRIENT LEVELS NUCLEUS Essential protein with two zinc fingers; present in the nucleus of growing cells but relocates to the cytoplasm in starved cells via a process mediated by Cpr1p; binds to translation elongation factor eEF-1 (Tef1p); relative distribution to the nucleus increases upon DNA replication stress regulation of mitotic cell cycle|cellular response to starvation protein binding nucleus|cytoplasm
YBR256C YBR256C RIB5 het Verified -0.720897806494709 0.235486196268448 no 847 0.246685223228907 2556 NA FT OXIDATION-REDUCTION PROCESS Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway riboflavin biosynthetic process riboflavin synthase activity cellular_component
YPR165W YPR165W RHO1 het Verified -0.721675943253868 0.23524686793998 no 848 0.280818433018079 2451 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM|CYTOSKELETON ORGANIZATION MITOCHONDRION|GOLGI APPARATUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p) regulation of fungal-type cell wall (1->3)-alpha-glucan biosynthetic process|regulation of fungal-type cell wall organization|positive regulation of endocytosis|budding cell bud growth|small GTPase mediated signal transduction|regulation of protein localization|positive regulation of protein kinase C signaling cascade|actin cytoskeleton organization|regulation of vacuole fusion, non-autophagic|actin cytoskeleton reorganization|regulation of exocyst localization|regulation of cell size GTPase activity|signal transducer activity incipient cellular bud site|mitochondrion|Golgi apparatus|peroxisome|cellular bud neck|cellular bud tip|mitochondrial outer membrane|1,3-beta-D-glucan synthase complex|plasma membrane|mating projection tip
YGR278W YGR278W CWC22 het Verified -0.723868947038484 0.234573097916287 no 849 0.213325028169191 2674 NA FT RNA PROCESSING NUCLEUS Spliceosome-associated protein that is required for pre-mRNA splicing; necessary for Prp2p function at the first catalytic step of splicing; has similarity to S. pombe Cwf22p; CWC22 is an essential protein mRNA splicing, via spliceosome molecular_function U2-type spliceosomal complex|U2-type catalytic step 1 spliceosome
YJL111W YJL111W CCT7 het Verified -0.728163883995166 0.233256635616895 no 850 0.274915380442435 2388 NA FF Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance protein folding unfolded protein binding chaperonin-containing T-complex|cytoplasm
YJL097W YJL097W PHS1 het Verified -0.728368196498554 0.233194113119246 no 851 0.227564962548875 2599 NA FT KETONE METABOLISM|LIPID METABOLISM|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Essential 3-hydroxyacyl-CoA dehydratase of the ER membrane, involved in elongation of very long-chain fatty acids; evolutionarily conserved, similar to mammalian PTPLA and PTPLB; involved in sphingolipid biosynthesis and protein trafficking vacuolar transport|sphingolipid biosynthetic process enoyl-CoA hydratase activity fungal-type vacuole membrane|integral to endoplasmic reticulum membrane|integral to membrane|endoplasmic reticulum|fungal-type vacuole|nuclear outer membrane-endoplasmic reticulum membrane network
YGR274C YGR274C TAF1 het Verified -0.730165019835666 0.232644660753814 no 852 0.244143176241306 2567 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS RNA POL II, HOLOENZYME TFIID subunit (145 kDa), involved in RNA polymerase II transcription initiation; possesses in vitro histone acetyltransferase activity but its role in vivo appears to be minor; involved in promoter binding and G1/S progression RNA polymerase II transcriptional preinitiation complex assembly|transcription from RNA polymerase II promoter TBP-class protein binding|chromatin binding|protein complex scaffold|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly|histone acetyltransferase activity transcription factor TFIID complex
YPL142C_d YPL142C YPL142C het Dubious -0.730717014574025 0.232476010353467 no 853 0.23871843382113 2552 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPL33A/YPL143W, a component of the large (60S) ribosomal subunit Unknown Unknown Unknown
YPR048W YPR048W TAH18 het Verified -0.731207223696667 0.232326294268556 no 854 0.217554121343159 2655 NA FT OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM MITOCHONDRION Conserved NAPDH-dependent diflavin reductase; component of an early step in the cytosolic Fe-S protein assembly (CIA) machinery; transfers electrons from NADPH to the Fe-S cluster of Dre2p; plays a pro-death role under oxidative stress; Tah18p-dependent nitric oxide synthesis confers high-temperature stress tolerance oxidation-reduction process|iron-sulfur cluster assembly oxidoreductase activity, acting on NADH or NADPH mitochondrion
YGL008C YGL008C PMA1 het Verified -0.733480688704584 0.231632650925356 no 855 0.213734212389183 2632 NA FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS MITOCHONDRION|PLASMA MEMBRANE Plasma membrane H+-ATPase, pumps protons out of the cell; major regulator of cytoplasmic pH and plasma membrane potential; P2-type ATPase; Hsp30p plays a role in Pma1p regulation; interactions with Std1p appear to propagate [GAR+] proton transport|regulation of pH|transmembrane transport hydrogen-exporting ATPase activity, phosphorylative mechanism mitochondrion|integral to membrane|membrane raft|plasma membrane
YER112W YER112W LSM4 het Verified -0.735887467584846 0.230899592374814 no 856 0.255212196254834 2530 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; forms cytoplasmic foci upon DNA replication stress nuclear-transcribed mRNA catabolic process|mRNA splicing, via spliceosome|cytoplasmic mRNA processing body assembly U6 snRNA binding U6 snRNP|nucleolus|small nucleolar ribonucleoprotein complex|cytoplasmic mRNA processing body|U4/U6 x U5 tri-snRNP complex
YLR163C YLR163C MAS1 het Verified -0.736664524979704 0.230663192560793 no 857 0.297093966202106 2363 NA FF|FT PROTEIN LOCALIZATION|PROTEOLYSIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Smaller subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins protein processing involved in protein targeting to mitochondrion metalloendopeptidase activity mitochondrion|mitochondrial processing peptidase complex
YML065W YML065W ORC1 het Verified -0.737209399891663 0.230497509006963 no 858 0.18452939566376 2728 NA FT GENE SILENCING NUCLEUS|CHROMOSOME Largest subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; exhibits ATPase activity pre-replicative complex assembly|DNA replication initiation|chromatin silencing at silent mating-type cassette chromatin binding|DNA replication origin binding|ATPase activity|ATP binding DNA replication preinitiation complex|nucleus|pre-replicative complex|nuclear origin of replication recognition complex
YDR086C YDR086C SSS1 het Verified -0.738038313650997 0.230245583585616 no 859 0.24914036626332 2543 NA FT PROTEIN LOCALIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p posttranslational protein targeting to membrane, translocation|SRP-dependent cotranslational protein targeting to membrane, translocation structural molecule activity|P-P-bond-hydrolysis-driven protein transmembrane transporter activity Sec61 translocon complex|Ssh1 translocon complex
YLR140W_d YLR140W YLR140W het Dubious -0.738456030844537 0.230118688372426 no 860 0.234792754913176 2585 NA Dubious open reading frame unlikely to encode a functional protein; overlaps essential RRN5 gene which encodes a member of the UAF transcription factor involved in transcription of rDNA by RNA polymerase I Unknown Unknown Unknown
YOR060C YOR060C SLD7 het Verified -0.73933524182431 0.229851727270303 no 861 0.202994656539714 2728 NA FT CELL CYCLE ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|CYTOSKELETON Protein with a role in chromosomal DNA replication; interacts with Sld3p and reduces its affinity for Cdc45p; deletion mutant has aberrant mitochondria regulation of DNA-dependent DNA replication initiation molecular_function nuclear envelope|endoplasmic reticulum|DNA replication preinitiation complex|nucleus|spindle pole body|cytoplasm
YGR277C YGR277C CAB4 het Verified -0.740651057121159 0.229452520999148 no 862 0.203872956618923 2680 NA FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM NUCLEUS Probable pantetheine-phosphate adenylyltransferase (PPAT), which catalyzes the fourth step in the biosynthesis of coenzyme A from pantothenate; null mutant lethality is complemented by E. coli coaD (encoding PPAT); widely conserved coenzyme A biosynthetic process pantetheine-phosphate adenylyltransferase activity nucleus|cytoplasm
YPR143W YPR143W RRP15 het Verified -0.741079733845733 0.229322548384031 no 863 0.22901329707075 2619 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Nucleolar protein, constituent of pre-60S ribosomal particles; required for proper processing of the 27S pre-rRNA at the A3 and B1 sites to yield mature 5.8S and 25S rRNAs maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function nucleolus|nucleus|preribosome, large subunit precursor
YGR267C YGR267C FOL2 het Verified -0.748648668212539 0.22703449512195 no 864 0.211592782975894 2693 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM NUCLEUS GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway folic acid-containing compound biosynthetic process GTP cyclohydrolase I activity nucleus|cytoplasm
YDR407C YDR407C TRS120 het Verified -0.749191579610025 0.226870871808003 no 865 0.218715301317454 2670 NA FT VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM GOLGI APPARATUS One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic regulation of Rab GTPase activity|early endosome to Golgi transport|intra-Golgi vesicle-mediated transport Rab guanyl-nucleotide exchange factor activity trans-Golgi network|TRAPP complex|early endosome
YIL062C YIL062C ARC15 het Verified -0.75113897806922 0.226284509974555 no 866 0.212230436436399 2676 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION MITOCHONDRION|CYTOSKELETON Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; has mRNA binding activity mitochondrion inheritance|actin cortical patch assembly mRNA binding|structural molecule activity Arp2/3 protein complex|extrinsic to mitochondrial outer membrane
YDR288W YDR288W NSE3 het Verified -0.751223909447958 0.226258956627521 no 867 0.251273319101547 2501 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; protein abundance increases in response to DNA replication stress DNA repair DNA binding Smc5-Smc6 complex|nucleus|cytoplasm
YJL104W YJL104W PAM16 het Verified -0.753973923287959 0.225432440037994 no 868 0.206556062919143 2641 NA FT PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Constituent of the import motor (PAM complex) component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); forms a 1:1 subcomplex with Pam18p and inhibits its cochaperone activity; contains a J-like domain protein import into mitochondrial matrix protein domain specific binding mitochondrion|presequence translocase-associated import motor|mitochondrial inner membrane presequence translocase complex
YPL094C YPL094C SEC62 het Verified -0.755175828148706 0.225071745018288 no 869 0.19731368393174 2727 NA FT PROTEIN LOCALIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER posttranslational protein targeting to membrane, translocation protein transporter activity integral to membrane|Sec62/Sec63 complex|endoplasmic reticulum membrane
YNL103W YNL103W MET4 het Verified -0.757132775796466 0.22448515980424 no 870 0.231803904482772 2591 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p response to cadmium ion|sulfur amino acid metabolic process|response to arsenic-containing substance|positive regulation of transcription from RNA polymerase II promoter transcription coactivator activity nucleus
YOR004W YOR004W UTP23 het Verified -0.757319856581728 0.224429128745938 no 871 0.181252534544639 2777 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS|MITOCHONDRION Component of the small subunit processome, involved in 40S ribosomal subunit biogenesis; interacts with snR30 and is required for dissociation of snR30 from large pre-ribosomal particles; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function; essential protein endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function small-subunit processome|mitochondrion|nucleolus
YER025W YER025W GCD11 het Verified -0.757728926312876 0.224306639223487 no 872 0.272563116592217 2445 NA FT TRANSLATION|NUCLEOTIDE METABOLISM RIBOSOME Gamma subunit of the translation initiation factor eIF2, involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met positive regulation of translational fidelity GTP binding|tRNA binding|translation initiation factor activity multi-eIF complex|ribosome|eukaryotic translation initiation factor 2 complex
YOR244W YOR244W ESA1 het Verified -0.758188433632778 0.224169092226553 no 873 0.219065570306337 2656 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING NUCLEUS HISTONE ACETYLTRANSFERASE Catalytic subunit of the histone acetyltransferase complex (NuA4); acetylates four conserved internal lysines of histone H4 N-terminal tail and can acetylate histone H2A; required for cell cycle progression and transcriptional silencing at the rDNA locus and regulation of autophagy DNA repair|histone acetylation|regulation of cell cycle|regulation of transcription by chromatin organization|DNA-dependent transcription, elongation|chromatin silencing at rDNA|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter H4 histone acetyltransferase activity|histone acetyltransferase activity Piccolo NuA4 histone acetyltransferase complex|NuA4 histone acetyltransferase complex
YKL196C YKL196C YKT6 het Verified -0.759384618485665 0.223811255995249 no 874 0.202228046174875 2697 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION MITOCHONDRION|GOLGI APPARATUS|PLASMA MEMBRANE Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminus intra-Golgi vesicle-mediated transport|vacuole fusion, non-autophagic|vesicle fusion palmitoyltransferase activity|SNAP receptor activity SNARE complex|endosome|mitochondrion|Golgi apparatus|fungal-type vacuole|membrane
YLR212C YLR212C TUB4 het Verified -0.761928238965319 0.223051417440528 no 875 0.184718052546834 2793 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION NUCLEUS|CYTOSKELETON Gamma-tubulin; involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body; protein abundance increases in response to DNA replication stress microtubule nucleation|mitotic spindle organization in nucleus structural constituent of cytoskeleton outer plaque of spindle pole body|gamma-tubulin small complex, spindle pole body|inner plaque of spindle pole body
YBL074C YBL074C AAR2 het Verified -0.767547382272816 0.221378066483639 no 876 0.210982196162091 2677 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING NUCLEUS Component of the U5 snRNP, required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron assembly of spliceosomal tri-snRNP molecular_function U5 snRNP
YPL093W YPL093W NOG1 het Verified -0.771978134684098 0.220063688949496 no 877 0.247335668214228 2570 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Putative GTPase that associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN family of nucleolar G-proteins ribosomal subunit export from nucleus|ribosomal large subunit biogenesis|rRNA processing GTP binding nucleolus|preribosome, large subunit precursor
YGR113W YGR113W DAM1 het Verified -0.774685842012611 0.219262659499065 no 878 0.222806406823435 2621 NA FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME|CYTOSKELETON KINETOCHORE Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; Ipl1p target for regulating kinetochore-MT attachments mitotic spindle organization in nucleus|regulation of microtubule polymerization or depolymerization microtubule binding|structural constituent of cytoskeleton spindle midzone|DASH complex|condensed nuclear chromosome kinetochore|kinetochore microtubule|spindle
YJR064W YJR064W CCT5 het Verified -0.776912044637002 0.218605332284307 no 879 0.261457601402953 2493 NA Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo protein folding unfolded protein binding chaperonin-containing T-complex
YMR270C YMR270C RRN9 het Verified -0.780831248491684 0.217450876293933 no 880 0.205163831872886 2697 NA FT NUCLEUS Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I transcription of nuclear large rRNA transcript from RNA polymerase I promoter TBP-class protein binding|RNA polymerase I upstream control element sequence-specific DNA binding transcription factor activity nucleolus|RNA polymerase I upstream activating factor complex
YIR008C YIR008C PRI1 het Verified -0.784785771279155 0.216289591972512 no 881 0.197146834644935 2715 NA FT NUCLEUS|CHROMOSOME Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair lagging strand elongation|DNA replication, synthesis of RNA primer|DNA replication initiation|DNA replication single-stranded DNA binding|DNA primase activity alpha DNA polymerase:primase complex|nuclear replication fork
YGL040C YGL040C HEM2 het Verified -0.786527516471715 0.215779252513009 no 882 0.214031794985506 2680 NA FT COFACTOR METABOLISM NUCLEUS Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus heme biosynthetic process porphobilinogen synthase activity nucleus|cytoplasm
YPL010W YPL010W RET3 het Verified -0.788611217528984 0.2151696363061 no 883 0.199264394033219 2681 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Zeta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER retrograde vesicle-mediated transport, Golgi to ER molecular_function COPI vesicle coat
YIL003W YIL003W CFD1 het Verified -0.793363294288569 0.213783094926733 no 884 0.242698104087898 2573 NA FT RNA PROCESSING|COFACTOR METABOLISM Highly conserved, iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Nbp35p that is involved in iron-sulfur protein assembly in the cytosol iron-sulfur cluster assembly|tRNA wobble uridine modification 4 iron, 4 sulfur cluster binding|ATPase activity cytoplasm
YMR203W YMR203W TOM40 het Verified -0.798271243154936 0.212356551057081 no 885 0.297571569392403 2405 NA FF|FT PROTEIN LOCALIZATION|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS MITOCHONDRION Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore protein import into mitochondrial matrix protein channel activity mitochondrial outer membrane|mitochondrion|integral to membrane|mitochondrial outer membrane translocase complex
YLR323C YLR323C CWC24 het Verified -0.799755423384855 0.211926257294028 no 886 0.17791957907179 2765 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING NUCLEUS Spliceosome assembly factor, essential for the first step of splicing; component of the pre-catalytic spliceosome complex containing Cef1p; has similarity to S. pombe Cwf24p generation of catalytic spliceosome for first transesterification step|snoRNA splicing molecular_function nucleus|U2-type spliceosomal complex
YLR127C YLR127C APC2 het Verified -0.806522055031875 0.209970948182162 no 887 0.174510090113552 2799 NA FT CELL CYCLE|CELL DIVISION|PROTEOLYSIS NUCLEUS UBIQUITIN LIGASE COMPLEX Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the catalytic core of the APC/C; has similarity to cullin Cdc53p mitotic metaphase/anaphase transition|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|exit from mitosis|cyclin catabolic process|protein ubiquitination ubiquitin-protein ligase activity anaphase-promoting complex
YLR259C YLR259C HSP60 het Verified -0.807023469998265 0.209826480713412 no 888 0.179954639718305 2774 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated protein refolding|protein stabilization|chaperone-mediated protein complex assembly|'de novo' protein folding|protein maturation|protein import into mitochondrial intermembrane space unfolded protein binding|DNA replication origin binding|single-stranded DNA binding|ATPase activity|chaperone binding mitochondrial nucleoid|mitochondrion
YOL078W YOL078W AVO1 het Verified -0.807038124078849 0.209822259464867 no 889 0.176303349133267 2774 NA FT SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION PLASMA MEMBRANE Component of a membrane-bound complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth TOR signaling cascade|fungal-type cell wall organization|regulation of cell growth|negative regulation of Ras protein signal transduction|establishment or maintenance of actin cytoskeleton polarity phosphatidylinositol-4,5-bisphosphate binding|Ras GTPase binding TORC2 complex|plasma membrane|cytoplasm
YPL238C_d YPL238C YPL238C het Dubious -0.80880551982603 0.209313510348834 no 890 0.27381046247363 2434 NA FF Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified essential gene SUI3/YPL237W Unknown Unknown Unknown
YOR259C YOR259C RPT4 het Verified -0.809374803044928 0.209149795518271 no 891 0.265503291642026 2487 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE|PROTEOLYSIS NUCLEUS One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in degradation of ubiquitinated substrates; contributes preferentially to ERAD; required for spindle pole body duplication; mainly nuclear localization ER-associated protein catabolic process|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription elongation from RNA polymerase II promoter|nucleotide-excision repair|proteasome regulatory particle assembly ATPase activity|protein domain specific binding proteasome regulatory particle, base subcomplex|nucleus
YOR336W YOR336W KRE5 het Verified -0.814667212375999 0.207631413049307 no 892 0.201402716781592 2711 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM ENDOPLASMIC RETICULUM Protein required for beta-1,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defects (1->6)-beta-D-glucan biosynthetic process UDP-glucose:glycoprotein glucosyltransferase activity endoplasmic reticulum
YHR190W YHR190W ERG9 het Verified -0.817290811276349 0.206881128317148 no 893 0.192861891214475 2716 NA FT LIPID METABOLISM|OXIDATION-REDUCTION PROCESS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION Farnesyl-diphosphate farnesyl transferase (squalene synthase), joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway ergosterol biosynthetic process squalene synthase activity|farnesyl-diphosphate farnesyltransferase activity mitochondrial outer membrane|integral to membrane|endoplasmic reticulum
YOR116C YOR116C RPO31 het Verified -0.82454817863749 0.204814076222904 no 894 0.26494959806209 2496 NA FF|FT NUCLEUS RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21 tRNA transcription from RNA polymerase III promoter DNA-directed RNA polymerase activity DNA-directed RNA polymerase III complex
YOR194C YOR194C TOA1 het Verified -0.82802832503519 0.20382722942313 no 895 0.200192756469613 2707 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME TFIIA large subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to largest and second largest subunits of human and Drosophila TFIIA transcription initiation from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly TBP-class protein binding|TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly transcription factor TFIIA complex
YLR276C YLR276C DBP9 het Verified -0.829219608653056 0.203490075596758 no 896 0.161243448888316 2829 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS DEAD-box protein required for 27S rRNA processing; exhibits DNA, RNA and DNA/RNA helicase activities; ATPase activity shows preference for DNA over RNA; DNA helicase activity abolished by mutation in RNA-binding domain maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ATP-dependent DNA helicase activity|ATP-dependent DNA/RNA helicase activity|ATP-dependent RNA helicase activity nucleolus
YHR005C-A YHR005C-A TIM10 het Verified -0.829946308399262 0.203284570485531 no 897 0.199643000118884 2670 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner membrane protein import into mitochondrial inner membrane protein transporter activity|unfolded protein binding mitochondrion|integral to membrane|mitochondrial inner membrane protein insertion complex|mitochondrial intermembrane space protein transporter complex
YBL105C YBL105C PKC1 het Verified -0.831001951474773 0.202986263466128 no 898 0.281482502018402 2433 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC) intracellular protein kinase cascade|regulation of nuclear-transcribed mRNA poly(A) tail shortening|fungal-type cell wall organization|signal transduction|actin filament organization|peroxisome degradation|protein phosphorylation|cytoplasmic mRNA processing body assembly protein kinase C activity site of polarized growth|cytoskeleton|nucleus|plasma membrane|cytoplasm
YDR362C YDR362C TFC6 het Verified -0.831517667160819 0.202840625967858 no 899 0.22597830134905 2642 NA FT NUCLEUS One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; cooperates with Tfc3p in DNA binding; human homolog is TFIIIC-110 transcription from a RNA polymerase III hybrid type promoter|transcription from RNA polymerase III type 2 promoter|5S class rRNA transcription from RNA polymerase III type 1 promoter RNA polymerase III type 1 promoter sequence-specific DNA binding|RNA polymerase III type 2 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity|RNA polymerase III type 2 promoter sequence-specific DNA binding|RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity transcription factor TFIIIC complex
YLR355C YLR355C ILV5 het Verified -0.845097195238586 0.199028287093443 no 900 0.238768188039586 2588 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION MITOCHONDRION Bifunctional acetohydroxyacid reductoisomerase and mtDNA binding protein; involved in branched-chain amino acid biosynthesis and maintenance of wild-type mitochondrial DNA; found in mitochondrial nucleoids mitochondrial genome maintenance|branched-chain amino acid biosynthetic process double-stranded DNA binding|ketol-acid reductoisomerase activity mitochondrial nucleoid|mitochondrion
YJR007W YJR007W SUI2 het Verified -0.846195002083935 0.198721984805933 no 901 0.262455792239533 2489 NA FF|FT TRANSLATION RIBOSOME Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress translational initiation translation initiation factor activity ribosome|multi-eIF complex|eukaryotic translation initiation factor 2 complex|cytoplasm
YIL051C YIL051C MMF1 het Verified -0.849484441303302 0.197805892049178 no 902 0.17132555324458 2764 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial protein required for transamination of isoleucine but not of valine or leucine; may regulate specificity of branched-chain transaminases Bat1p and Bat2p; interacts genetically with mitochondrial ribosomal protein genes isoleucine biosynthetic process|mitochondrial translation molecular_function mitochondrion|mitochondrial matrix
YKL108W YKL108W SLD2 het Verified -0.852151748626975 0.197064936660624 no 903 0.153216946716505 2837 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS Single-stranded DNA origin-binding and annealing protein; required for the initiation of DNA replication; phosphorylated in S phase by cyclin-dependent kinases (Cdks), promoting origin binding, DNA replication and Dpb11p complex formation; component of the preloading complex; unphosphorylated or CDK-phosphorylated Sld2p binds to the MCM2-7 complex;required for the S phase checkpoint; relative distribution to the nucleus increases upon DNA replication stress DNA replication preinitiation complex assembly|DNA strand renaturation|DNA replication initiation|double-strand break repair via break-induced replication|mitotic cell cycle DNA replication checkpoint DNA replication origin binding|single-stranded DNA binding DNA replication preinitiation complex
YPL175W YPL175W SPT14 het Verified -0.853164185437169 0.196784130660998 no 904 0.221138116054446 2651 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis, mutations cause defects in transcription and in biogenesis of cell wall proteins GPI anchor biosynthetic process UDP-glycosyltransferase activity glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|endoplasmic reticulum
YDL007W YDL007W RPT2 het Verified -0.853875133464849 0.196587089452673 no 905 0.199497950855421 2707 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS NUCLEUS One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle positive regulation of protein catabolic process|proteasome regulatory particle assembly|peptide catabolic process|ubiquitin-dependent protein catabolic process ATPase activity proteasome regulatory particle, base subcomplex|nucleus
YPL243W YPL243W SRP68 het Verified -0.857927470925474 0.195466257045817 no 906 0.17026670008879 2826 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS NUCLEUS Core component of the signal recognition particle (SRP) complex; SRP complex functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition|protein targeting to ER signal sequence binding signal recognition particle, endoplasmic reticulum targeting
YGL093W YGL093W SPC105 het Verified -0.859240376998723 0.195103955593523 no 907 0.254852562156315 2571 NA FF|FT PROTEIN LOCALIZATION|CELL CYCLE|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION|CHROMOSOME|CYTOSKELETON KINETOCHORE Subunit of a kinetochore-microtubule binding complex with Kre28p that bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components microtubule nucleation|protein localization to kinetochore|sister chromatid biorientation|mitotic cell cycle spindle assembly checkpoint microtubule binding|structural constituent of cytoskeleton mitochondrion|condensed nuclear chromosome kinetochore|spindle pole body
YHR069C YHR069C RRP4 het Verified -0.86551369182132 0.193378452137343 no 908 0.222669994518692 2630 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|RNA LOCALIZATION NUCLEUS Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; has similarity to human hRrp4p (EXOSC2) nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear polyadenylation-dependent mRNA catabolic process|nonfunctional rRNA decay|U4 snRNA 3'-end processing|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription|polyadenylation-dependent snoRNA 3'-end processing|nuclear-transcribed mRNA catabolic process, non-stop decay|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)
YCR012W YCR012W PGK1 het Verified -0.875332956399408 0.190696383595205 no 909 0.143563401928187 2928 NA FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION 3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis gluconeogenesis|glycolysis phosphoglycerate kinase activity mitochondrion|plasma membrane|cytoplasm
YER125W YER125W RSP5 het Verified -0.876784654645066 0.190301807786831 no 910 0.223917112000166 2664 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|PROTEIN COMPLEX ORG/BIOGENESIS|LIPID METABOLISM|MEMBRANE ORGANIZATION|RNA PROCESSING|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION|PROTEOLYSIS|MITOCHONDRION ORGAN NUCLEUS|MITOCHONDRION|GOLGI APPARATUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE UBIQUITIN LIGASE COMPLEX E3 ubiquitin ligase of the NEDD4 family; involved in regulating many cellular processes including MVB sorting, heat shock response, transcription, endocytosis, and ribosome stability; human homolog is involved in Liddle syndrome; mutant tolerates aneuploidy; ubiquitylates Sec23p cellular response to UV|late endosome to vacuole transport via multivesicular body sorting pathway|chromatin assembly or disassembly|response to drug|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|ubiquitin-dependent endocytosis|protein monoubiquitination|positive regulation of fatty acid biosynthetic process|positive regulation of receptor-mediated endocytosis|regulation of phosphate metabolic process|regulation of ubiquinone biosynthetic process|regulation of dolichol biosynthetic process|regulation of multivesicular body size|positive regulation of transcription from RNA polymerase II promoter|regulation of nitrogen utilization|proteasomal ubiquitin-dependent protein catabolic process|positive regulation of endocytosis|regulation of actin cytoskeleton organization|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|regulation of protein localization|mitochondrion organization|regulation of mRNA export from nucleus|regulation of ergosterol biosynthetic process|ribophagy|Unknown|protein polyubiquitination ubiquitin binding|ubiquitin-protein ligase activity|phosphatidylinositol binding mitochondrion|ubiquitin ligase complex|Golgi apparatus|cytoplasm|cellular bud tip|endosome membrane|extrinsic to internal side of plasma membrane|plasma membrane|nucleus
YDL165W YDL165W CDC36 het Verified -0.877440556605183 0.190123696327931 no 911 0.187757861569598 2751 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RNA PROCESSING NUCLEUS Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor response to pheromone involved in conjugation with cellular fusion|regulation of cell cycle|deadenylation-independent decapping of nuclear-transcribed mRNA|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|negative regulation of transcription from RNA polymerase II promoter|nuclear-transcribed mRNA poly(A) tail shortening|transcription elongation from RNA polymerase II promoter|protein ubiquitination ubiquitin-protein ligase activity CCR4-NOT core complex|nucleus|cytoplasm
YFL002C YFL002C SPB4 het Verified -0.881322423357678 0.189071666379802 no 912 0.226770115119938 2660 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients ribosomal large subunit assembly|rRNA processing ATP-dependent RNA helicase activity nucleolus|90S preribosome
YLR223C YLR223C IFH1 het Verified -0.882478913847351 0.188758938844237 no 913 0.166297840055213 2795 NA FT TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|GENE SILENCING NUCLEUS|CHROMOSOME Coactivator that regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter|chromatin silencing at telomere transcription coactivator activity nuclear chromatin|nucleolus|nucleus|CURI complex
YLL050C YLL050C COF1 het Verified -0.885104240323974 0.188050206341385 no 914 0.155849270575244 2847 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION NUCLEUS|CYTOSKELETON Cofilin, involved in pH-dependent actin filament depolarization; binds both actin monomers and filaments and severs filaments; involved in the selective sorting, export of the secretory cargo from the late golgi; genetically interacts with pmr1; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes actin filament depolymerization|actin filament severing actin filament binding plasma membrane|actin cortical patch
YIL109C YIL109C SEC24 het Verified -0.891671197717475 0.186284597934149 no 915 0.162358354688823 2847 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sfb2p and Sfb3p cargo loading into COPII-coated vesicle signal sequence binding COPII vesicle coat
YKR025W YKR025W RPC37 het Verified -0.894813672579392 0.185443350104791 no 916 0.175071847854091 2744 NA FT NUCLEUS RNA polymerase III subunit C37 tRNA transcription from RNA polymerase III promoter DNA-directed RNA polymerase activity DNA-directed RNA polymerase III complex
YPL012W YPL012W RRP12 het Verified -0.901042257768278 0.183782926009476 no 917 0.18173212389689 2747 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS RIBOSOME Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; has a role in nuclear import in association with Pse1p; contains HEAT-repeats maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosome biogenesis molecular_function ribosome|nucleus|90S preribosome
YJL069C YJL069C UTP18 het Verified -0.908229435316474 0.18187850770362 no 918 0.156966122078197 2814 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function small-subunit processome|nucleolus|Pwp2p-containing subcomplex of 90S preribosome|90S preribosome
YLR106C YLR106C MDN1 het Verified -0.911832576031019 0.180928429478907 no 919 0.155540227720071 2833 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEOTIDE METABOLISM NUCLEUS|MITOCHONDRION Huge dynein-related AAA-type ATPase (midasin), forms extended pre-60S particle with the Rix1 complex (Rix1p-Ipi1p-Ipi3p); acts in removal of ribosomal biogenesis factors at successive steps of pre-60S assembly and export from nucleus ribosomal large subunit assembly|rRNA processing ATPase activity nucleoplasm|mitochondrion|nucleus
YML125C YML125C PGA3 het Verified -0.919629007933834 0.178883331301389 no 920 0.148316884703752 2829 NA FT PROTEIN LOCALIZATION|OXIDATION-REDUCTION PROCESS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Putative cytochrome b5 reductase, localized to the plasma membrane; may be involved in regulation of lifespan; required for maturation of Gas1p and Pho8p, proposed to be involved in protein trafficking; PGA3 has a paralog, AIM33, that arose from the whole genome duplication protein transport|chronological cell aging|replicative cell aging molecular_function endoplasmic reticulum|plasma membrane
YDR376W YDR376W ARH1 het Verified -0.92216730572153 0.178220656952476 no 921 0.156273708571565 2864 NA FT KETONE METABOLISM|ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability ubiquinone biosynthetic process|cellular iron ion homeostasis NADPH-adrenodoxin reductase activity mitochondrion|mitochondrial inner membrane
YGR172C YGR172C YIP1 het Verified -0.925058655241308 0.177467698853554 no 922 0.172280154934223 2800 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Integral membrane protein required for the biogenesis of ER-derived COPII transport vesicles; interacts with Yif1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; homolog of human YIPF4 vesicle-mediated transport|ER to Golgi vesicle-mediated transport|vesicle fusion with Golgi apparatus molecular_function integral to membrane|ER to Golgi transport vesicle|integral to Golgi membrane|endoplasmic reticulum membrane
YFR029W YFR029W PTR3 het Verified -0.931038424730981 0.175916844097951 no 923 0.149996810622076 2892 NA FT PLASMA MEMBRANE Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes response to amino acid stimulus molecular_function extrinsic to plasma membrane
YNR046W YNR046W TRM112 het Verified -0.946247432241473 0.172011199270145 no 924 0.135059134017932 2904 NA FT RNA PROCESSING NUCLEUS Protein involved in methylation of tRNA, rRNA, and translation factors; subunit of tRNA methyltransferase (MTase) complexes in combination with Trm9p and Trm11p; interacts with and stabilizes 18S rRNA methyltransferase Bud23p; subunit of complex with Mtq2p that methylates Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; deletion confers resistance to zymocin; relative distribution to the nucleus increases upon DNA replication stress rRNA (guanine-N7)-methylation|peptidyl-glutamine methylation|tRNA methylation protein methyltransferase activity|zinc ion binding|tRNA (guanine-N2-)-methyltransferase activity|rRNA (guanine) methyltransferase activity eRF1 methyltransferase complex|nucleolus|nucleus|tRNA (m2G10) methyltransferase complex|cytoplasm
YPL231W YPL231W FAS2 het Verified -0.947896450155116 0.171591086149428 no 925 0.157323505184592 2821 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION Alpha subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains the acyl-carrier protein domain and beta-ketoacyl reductase, beta-ketoacyl synthase and self-pantetheinylation activities fatty acid biosynthetic process holo-[acyl-carrier-protein] synthase activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|fatty acid synthase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity cytosol|fatty acid synthase complex|mitochondrion|cytoplasm
YGL018C YGL018C JAC1 het Verified -0.953511182273654 0.170165566595861 no 926 0.156265918140174 2844 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Specialized J-protein that functions with Hsp70 in Fe-S cluster biogenesis in mitochondria, involved in iron metabolism; contains a J domain typical to J-type chaperones; localizes to the mitochondrial matrix iron-sulfur cluster assembly|aerobic respiration chaperone binding mitochondrion
YDR327W_d YDR327W YDR327W het Dubious -0.95916779061157 0.168737111903472 no 927 0.173032236576344 2783 NA Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SKP1 Unknown Unknown Unknown
YHR042W YHR042W NCP1 het Verified -0.960670379963762 0.168358964427385 no 928 0.158245254333951 2887 NA FT LIPID METABOLISM|OXIDATION-REDUCTION PROCESS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|PLASMA MEMBRANE NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p ergosterol biosynthetic process electron carrier activity mitochondrial outer membrane|mitochondrion
YDR177W YDR177W UBC1 het Verified -0.965015421597948 0.167268543793558 no 929 0.186797264216476 2749 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEOLYSIS Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived and abnormal proteins; plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD); component of the cellular stress response; protein abundance increases in response to DNA replication stress spore germination|vesicle organization|endocytosis|ER-associated protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein polyubiquitination|protein monoubiquitination ubiquitin-protein ligase activity proteasome complex
YGR094W YGR094W VAS1 het Verified -0.97027127084349 0.165955646763032 no 930 0.136643152821617 2911 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION MITOCHONDRION Mitochondrial and cytoplasmic valyl-tRNA synthetase valyl-tRNA aminoacylation valine-tRNA ligase activity mitochondrion|cytoplasm
YJR072C YJR072C NPA3 het Verified -0.98396610721691 0.162566088856786 no 931 0.127402232147634 2950 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CHROMOSOME SEGREGATION Member of the conserved GPN-loop GTPase family; has a role in transport of RNA polymerase II to the nucleus; exhibits GTP-dependent binding to PolII; has ATPase activity; involved in sister chromatid cohesion; phosphorylated by the Pcl1p-Pho85p kinase complex; human homolog XAB1 interacts with human RNA polymerase II; protein abundance increases in response to DNA replication stress cellular protein complex localization|nucleocytoplasmic transport|mitotic sister chromatid cohesion ATPase activity|GTPase activity cytoplasm
YNL002C YNL002C RLP7 het Verified -0.989255687200139 0.161269029396186 no 932 0.178275439222504 2774 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION NUCLEUS Nucleolar protein with similarity to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs ribosomal large subunit biogenesis|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) rRNA binding nucleolus|preribosome, large subunit precursor
YLR458W_d YLR458W YLR458W het Dubious -0.993644744416358 0.16019792620749 no 933 0.149088823523713 2887 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential NBP1 gene required for mitosis Unknown Unknown Unknown
YER023W YER023W PRO3 het Verified -0.99648398024777 0.159507523444069 no 934 0.126568253410419 2934 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS Delta 1-pyrroline-5-carboxylate reductase, catalyzes the last step in proline biosynthesis proline biosynthetic process pyrroline-5-carboxylate reductase activity cytoplasm
YPL085W YPL085W SEC16 het Verified -0.997099256123453 0.159358167036434 no 935 0.138081887873709 2887 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM COPII vesicle coat protein required for ER transport vesicle budding; Sec16p is bound to the periphery of ER membranes and may act to stabilize initial COPII complexes; interacts with Sec23p, Sec24p and Sec31p COPII vesicle coating protein anchor ER to Golgi transport vesicle membrane
YML127W YML127W RSC9 het Verified -1.00052218513669 0.158528933405561 no 936 0.306898021650842 2354 NA FF|FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION NUCLEUS RSC COMPLEX Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway G2/M transition of mitotic cell cycle|ATP-dependent chromatin remodeling|nucleosome disassembly|rRNA transcription|regulation of transcription from RNA polymerase II promoter|chromatin remodeling|transcription elongation from RNA polymerase II promoter|response to stress chromatin binding|DNA translocase activity RSC complex
YFL024C YFL024C EPL1 het Verified -1.00223434872811 0.158115210947333 no 937 0.157273276470531 2878 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS HISTONE ACETYLTRANSFERASE Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC (nucleosome core particle); required for autophagy; homologous to Drosophila Enhancer of Polycomb DNA repair|histone acetylation|regulation of transcription from RNA polymerase II promoter histone acetyltransferase activity Piccolo NuA4 histone acetyltransferase complex|NuA4 histone acetyltransferase complex
YBL018C YBL018C POP8 het Verified -1.00384199508153 0.157727389449595 no 938 0.14091659023599 2864 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs tRNA processing|intronic box C/D snoRNA processing|mRNA cleavage|rRNA processing ribonuclease MRP activity|ribonuclease P activity nucleolar ribonuclease P complex|ribonuclease MRP complex
YOR057W YOR057W SGT1 het Verified -1.00687622136962 0.15699713010043 no 939 0.148590732450552 2875 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|SIGNALING UBIQUITIN LIGASE COMPLEX Cochaperone protein; regulates activity of adenylyl cyclase Cyr1p; involved in kinetochore complex assembly; associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex; acts as a linker between Skp1p and HSP90 complexes; protein abundance increases in response to DNA replication stress regulation of cell cycle|kinetochore assembly|cAMP-mediated signaling|protein complex assembly|protein ubiquitination protein binding, bridging|chaperone binding ubiquitin ligase complex
YOL038W YOL038W PRE6 het Verified -1.01029659294144 0.156176606498238 no 940 0.184274673861133 2770 NA FT PROTEOLYSIS ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process molecular_function mitochondrion|proteasome core complex, alpha-subunit complex|proteasome storage granule|nucleus|nuclear outer membrane-endoplasmic reticulum membrane network
YJL081C YJL081C ARP4 het Verified -1.01201085280136 0.155766432177532 no 941 0.219373761819185 2671 NA FF|FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME HISTONE ACETYLTRANSFERASE Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes DNA repair|histone acetylation|kinetochore assembly|chromatin organization|regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|chromatin remodeling chromatin binding|histone acetyltransferase activity|ATP-dependent 3'-5' DNA helicase activity nuclear chromatin|Swr1 complex|nucleus|Ino80 complex|NuA4 histone acetyltransferase complex
YGR047C YGR047C TFC4 het Verified -1.01596936670062 0.15482198716211 no 942 0.133056890976993 2904 NA FT NUCLEUS One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TFIIIC-102 transcription from a RNA polymerase III hybrid type promoter|transcription from RNA polymerase III type 2 promoter|5S class rRNA transcription from RNA polymerase III type 1 promoter RNA polymerase III type 1 promoter sequence-specific DNA binding|RNA polymerase III type 2 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity|RNA polymerase III type 2 promoter sequence-specific DNA binding|RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity|DNA binding, bending transcription factor TFIIIC complex
YDR212W YDR212W TCP1 het Verified -1.01852665839081 0.154213869272407 no 943 0.189908810529002 2761 NA Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein protein folding unfolded protein binding plasma membrane|chaperonin-containing T-complex
YJL005W YJL005W CYR1 het Verified -1.0315945746393 0.151131041514764 no 944 0.127910539224683 2916 NA FT SIGNALING|NUCLEOTIDE METABOLISM MITOCHONDRION|PLASMA MEMBRANE Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation adenylate cyclase-modulating G-protein coupled receptor signaling pathway|Ras protein signal transduction adenylate cyclase activity mitochondrion|plasma membrane
YHR072W YHR072W ERG7 het Verified -1.03587819777057 0.150129485066093 no 945 0.147112574465564 2887 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis ergosterol biosynthetic process lanosterol synthase activity endoplasmic reticulum|lipid particle|plasma membrane
YKL210W YKL210W UBA1 het Verified -1.03906329041442 0.149387651152653 no 946 0.143769188290858 2936 NA FT NUCLEUS Ubiquitin activating enzyme (E1); involved in ubiquitin-mediated protein degradation and essential for viability; protein abundance increases in response to DNA replication stress protein ubiquitination ubiquitin activating enzyme activity nucleus|cytoplasm
YGR185C YGR185C TYS1 het Verified -1.03959742941004 0.149263485849752 no 947 0.114248626667046 2970 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION NUCLEUS Cytoplasmic tyrosyl-tRNA synthetase; required for cytoplasmic protein synthesis; interacts with positions 34 and 35 of the tRNATyr anticodon; mutations in human ortholog YARS are associated with Charcot-Marie-Tooth (CMT) neuropathies; protein abundance increases in response to DNA replication stress tyrosyl-tRNA aminoacylation tyrosine-tRNA ligase activity nucleus|cytoplasm
YLR029C YLR029C RPL15A het Verified -1.0423467784068 0.148625465954423 no 948 0.182358304903732 2790 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L15A; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15A has a paralog, RPL15B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YOL149W YOL149W DCP1 het Verified -1.04527655874502 0.147947584227673 no 949 0.152357428921337 2910 NA FT RNA PROCESSING Subunit of the Dcp1p-Dcp2p decapping enzyme complex; decapping complex removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p; forms cytoplasmic foci upon DNA replication stress deadenylation-dependent decapping of nuclear-transcribed mRNA mRNA binding|enzyme activator activity|m7G(5')pppN diphosphatase activity cytoplasmic mRNA processing body
YDL004W YDL004W ATP16 het Verified -1.05115572164431 0.146593537806396 no 950 0.161179215802432 2846 NA FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS MITOCHONDRION Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated ATP synthesis coupled proton transport hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism proton-transporting ATP synthase complex, catalytic core F(1)|mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase, central stalk
YOR329C YOR329C SCD5 het Verified -1.05997864654885 0.144577156980566 no 951 0.109347576923306 2973 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION NUCLEUS|CYTOSKELETON Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency protein secretion|endocytosis|actin filament organization|cortical actin cytoskeleton organization protein phosphatase 1 binding nucleus|actin cortical patch
YDR398W YDR398W UTP5 het Verified -1.06223750220774 0.144063939374178 no 952 0.160648719056949 2822 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS|CHROMOSOME Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit positive regulation of transcription from RNA polymerase I promoter|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function small-subunit processome|t-UTP complex|rDNA heterochromatin|nucleolus
YGL113W YGL113W SLD3 het Verified -1.06715723050041 0.142950421049441 no 953 0.173649605794173 2801 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Protein involved in the initiation of DNA replication; required for proper assembly of replication proteins at the origins of replication; interacts with Cdc45p; localizes to nuclear foci that become diffuse upon DNA replication stress DNA unwinding involved in replication|double-strand break repair via break-induced replication|DNA replication initiation chromatin binding nuclear chromatin|DNA replication preinitiation complex
YPR187W YPR187W RPO26 het Verified -1.07861229539104 0.140380298926992 no 954 0.198909201779027 2690 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit tRNA transcription from RNA polymerase III promoter|transcription from RNA polymerase I promoter|transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter RNA-directed RNA polymerase activity|DNA-directed RNA polymerase activity DNA-directed RNA polymerase III complex|DNA-directed RNA polymerase I complex|DNA-directed RNA polymerase II, core complex
YDL147W YDL147W RPN5 het Verified -1.0811708742295 0.13981055566788 no 955 0.181044090974971 2836 NA FT PROTEOLYSIS NUCLEUS Subunit of the COP9 signalosome (CSN) and non-ATPase regulatory subunit of the 26S proteasome lid, similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p; Rpn5p is an essential protein cullin deneddylation|ubiquitin-dependent protein catabolic process molecular_function proteasome complex|signalosome|proteasome storage granule|proteasome regulatory particle, lid subcomplex
YCR035C YCR035C RRP43 het Verified -1.08371195669464 0.139246266267782 no 956 0.175236058465626 2777 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp43p (OIP2, EXOSC8); protein abundance increases in response to DNA replication stress nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear polyadenylation-dependent mRNA catabolic process|nonfunctional rRNA decay|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|polyadenylation-dependent snoRNA 3'-end processing|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|nuclear-transcribed mRNA catabolic process, non-stop decay|ncRNA 3'-end processing molecular_function nucleoplasm|nucleolus|nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)|cytoplasm
YKL049C YKL049C CSE4 het Verified -1.09745810350761 0.136220592932617 no 957 0.0939824416818843 3045 NA FT CELL CYCLE|CHROMATIN ORGANIZATION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME KINETOCHORE Centromere protein that resembles histone H3; required for proper kinetochore function; homolog of human CENP-A; levels are regulated by E3 ubiquitin ligase Psh1p; Cse4p marks a subset of open chromatin; associated with promoters, accessible chromatin and RNA polymerase II-bound regions 2-micrometer plasmid partitioning|mitotic sister chromatid segregation sequence-specific DNA binding|centromeric DNA binding extrachromosomal circular DNA|nuclear nucleosome|condensed nuclear chromosome, centromeric region|centromere-specific nucleosome|kinetochore
YNL216W YNL216W RAP1 het Verified -1.12616767611837 0.130047276321426 no 958 0.141611142095314 2916 NA FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|GENE SILENCING NUCLEUS|CHROMOSOME Essential DNA-binding transcription regulator that binds at many loci; involved in either transcription activation or repression, chromatin silencing, and telomere length maintenance; conserved protein with an N-terminal BRCT domain, a central region with homology to the Myb DNA binding domain, and a C-terminal Rap1-specific protein-interaction domain (RCT domain) negative regulation of chromatin silencing|establishment of protein localization to chromatin|establishment of chromatin silencing at telomere|regulation of transcription by chromatin organization|protection from non-homologous end joining at telomere|negative regulation of transcription from RNA polymerase II promoter|telomere maintenance via telomere lengthening|telomere maintenance|regulation of glycolysis by positive regulation of transcription from RNA polymerase II promoter|establishment of protein localization to telomere|positive regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette|chromatin silencing at telomere core promoter proximal region sequence-specific DNA binding|DNA binding, bending|sequence-specific DNA binding|TFIID-class transcription factor binding|TBP-class protein binding RNA polymerase II transcription factor activity|telomeric DNA binding|RNA polymerase II transcription factor binding transcription factor activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|G-quadruplex DNA binding|nucleosomal DNA binding nuclear chromosome|nuclear nucleosome|nuclear chromosome, telomeric region|nuclear telomere cap complex
YPL252C YPL252C YAH1 het Verified -1.12812970522251 0.129632572783432 no 959 0.155483217616219 2863 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin ubiquinone biosynthetic process|iron-sulfur cluster assembly|heme a biosynthetic process oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor mitochondrial matrix
YGR091W YGR091W PRP31 het Verified -1.13564599903885 0.128052374639621 no 960 0.112807643296275 2960 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING NUCLEUS|MITOCHONDRION Splicing factor, component of the U4/U6-U5 snRNP complex mRNA splicing, via spliceosome|spliceosomal snRNP assembly molecular_function mitochondrion|U4/U6 x U5 tri-snRNP complex
YNL232W YNL232W CSL4 het Verified -1.14239120034184 0.126645723671406 no 961 0.125232924009355 2919 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain an S1 RNA binding domain; has similarity to human hCsl4p (EXOSC1) nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear polyadenylation-dependent mRNA catabolic process|nonfunctional rRNA decay|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|polyadenylation-dependent snoRNA 3'-end processing|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|nuclear-transcribed mRNA catabolic process, non-stop decay|ncRNA 3'-end processing molecular_function nucleus|nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)|cytoplasm
YJL015C_d YJL015C YJL015C het Dubious -1.14436552937619 0.1262360387564 no 962 0.118663935755317 2943 NA Dubious open reading frame unlikely to encode a functional protein; expression if heat-inducible; located in promoter region of essential CCT3 gene encoding a subunit of the cytosolic chaperonin Cct ring complex, overlaps ORF YJL016W Unknown Unknown Unknown
YKL154W YKL154W SRP102 het Verified -1.14645035400604 0.125804428987553 no 963 0.120506472893192 2946 NA FT PROTEIN LOCALIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors the alpha subunit, Srp101p to the ER membrane protein targeting to ER|SRP-dependent cotranslational protein targeting to membrane signal recognition particle binding|GTP binding|GTPase activity integral to endoplasmic reticulum membrane|signal recognition particle receptor complex
YBR154C YBR154C RPB5 het Verified -1.14693959451848 0.125703293507769 no 964 0.164314325175409 2861 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III; contacts DNA and affects transactivation tRNA transcription from RNA polymerase III promoter|transcription from RNA polymerase I promoter|transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter RNA-directed RNA polymerase activity|DNA-directed RNA polymerase activity DNA-directed RNA polymerase III complex|DNA-directed RNA polymerase I complex|DNA-directed RNA polymerase II, core complex
YGR074W YGR074W SMD1 het Verified -1.15186648909789 0.124687970290808 no 965 0.112185880110944 3009 NA FT RNA PROCESSING NUCLEUS Core Sm protein Sm D1; part of heteroheptameric complex (with Smb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D1; protein abundance increases in response to DNA replication stress mRNA splicing, via spliceosome mRNA binding commitment complex|U1 snRNP|U4/U6 x U5 tri-snRNP complex|U2-type prespliceosome|U5 snRNP
YLL036C YLL036C PRP19 het Verified -1.15233949216148 0.124590797311248 no 966 0.110022975236477 3025 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION Splicing factor associated with the spliceosome; contains a U-box, a motif found in a class of ubiquitin ligases, and a WD40 domain generation of catalytic spliceosome for first transesterification step ubiquitin-protein ligase activity|first spliceosomal transesterification activity mitochondrion|nucleus|Prp19 complex|cytoplasm|U2-type catalytic step 1 spliceosome
YDR238C YDR238C SEC26 het Verified -1.16298098478927 0.122418608741844 no 967 0.169019626805975 2816 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP) ER to Golgi vesicle-mediated transport molecular_function coated vesicle|COPI vesicle coat
YGL030W YGL030W RPL30 het Verified -1.16617480702368 0.121771888083937 no 968 0.12273713650838 2963 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal 60S subunit protein L30; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript; homologous to mammalian ribosomal protein L30, no bacterial homolog cytoplasmic translation|negative regulation of mRNA splicing, via spliceosome|negative regulation of translation|rRNA processing structural constituent of ribosome|RNA binding|pre-mRNA 5'-splice site binding cytosolic large ribosomal subunit|cytoplasm
YIR012W YIR012W SQT1 het Verified -1.16626160471677 0.121754345890036 no 969 0.103974420546524 3023 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS RIBOSOME Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress ribosomal large subunit assembly molecular_function cytosol|cytosolic ribosome|cytoplasm
YPL251W_d YPL251W YPL251W het Dubious -1.16700117000156 0.121604948524543 no 970 0.107204606065177 2993 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C Unknown Unknown Unknown
YKL189W YKL189W HYM1 het Verified -1.16827972592682 0.121346975268621 no 971 0.0705643892598348 3074 NA FT CELL DIVISION SITE OF POLARIZED GROWTH Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response cytokinesis, completion of separation|regulation of cell shape|regulation of transcription, DNA-dependent|budding cell apical bud growth molecular_function incipient cellular bud site|intracellular|cellular bud|mating projection tip
YGL128C YGL128C CWC23 het Verified -1.17292974422375 0.120411990245662 no 972 0.0872889260442234 3033 NA FT RNA PROCESSING NUCLEUS Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; has similarity to E. coli DnaJ and other DnaJ-like proteins and to S. pombe Cwf23p spliceosomal complex disassembly molecular_function U2-type spliceosomal complex
YBR002C YBR002C RER2 het Verified -1.17686114566426 0.119625466195759 no 973 0.147017785687292 2888 NA FF|FT VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting dolichol biosynthetic process|protein glycosylation|ER to Golgi vesicle-mediated transport dehydrodolichyl diphosphate synthase activity|prenyltransferase activity endoplasmic reticulum
YNL306W YNL306W MRPS18 het Verified -1.19133471495709 0.116761105447495 no 974 0.0772617177235706 3106 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit; essential for viability, unlike most other mitoribosomal proteins mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YMR227C YMR227C TAF7 het Verified -1.1949354806631 0.116056119540348 no 975 0.122324523015619 2986 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation RNA polymerase II transcriptional preinitiation complex assembly|transcription from RNA polymerase II promoter RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly nucleus|transcription factor TFIID complex
YBR080C YBR080C SEC18 het Verified -1.20305798445332 0.114476941407591 no 976 0.0926876971734781 3030 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RESPONSE TO NUTRIENT LEVELS SITE OF POLARIZED GROWTH ATPase required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, autophagy, and protein secretion; releases Sec17p from SNAP complexes; has similarity to mammalian NSF Golgi vesicle docking|SNARE complex disassembly|Golgi to plasma membrane protein transport|vesicle fusion with Golgi apparatus|vacuole fusion, non-autophagic|inter-Golgi cisterna vesicle-mediated transport|autophagic vacuole assembly ATPase activity mating projection tip|cytoplasm
YDR299W YDR299W BFR2 het Verified -1.21199631725385 0.112756895181737 no 977 0.0800796812154203 3067 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Essential protein that is a component of 90S preribosomes; may be involved in rRNA processing; multicopy suppressor of sensitivity to Brefeldin A; expression is induced during lag phase and also by cold shock rRNA processing molecular_function nucleolus|90S preribosome
YHR107C YHR107C CDC12 het Verified -1.2274952879919 0.109818245878495 no 978 0.127381690141887 2987 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION SITE OF POLARIZED GROWTH|CYTOSKELETON Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells maintenance of cell polarity|cell cycle cytokinesis|positive regulation of protein kinase activity|septin ring assembly protein complex scaffold|structural molecule activity|GTP binding|GTPase activity|1-phosphatidylinositol binding septin filament array|cellular bud neck septin ring|septin complex|cytoplasm|mating projection
YFR004W YFR004W RPN11 het Verified -1.23365103079169 0.108666484316734 no 979 0.131532098928953 2917 NA FT PROTEOLYSIS|MITOCHONDRION ORGANIZATION|PEROXISOME ORGANIZATION NUCLEUS|MITOCHONDRION Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid; couples the deubiquitination and degradation of proteasome substrates; involved, independent of catalytic activity, in fission of mitochondria and peroxisomes; protein abundance increases in response to DNA replication stress protein deubiquitination|proteasomal ubiquitin-dependent protein catabolic process|peroxisome fission|mitochondrial fission metallopeptidase activity|ubiquitin-specific protease activity cytosol|mitochondrion|proteasome storage granule|nucleus|proteasome regulatory particle, lid subcomplex
YHR065C YHR065C RRP3 het Verified -1.23467954864238 0.108474895101954 no 980 0.06259080803527 3137 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) RNA-dependent ATPase activity|ATP-dependent RNA helicase activity nucleolus
YOR319W YOR319W HSH49 het Verified -1.24195035069877 0.107127440552021 no 981 0.168114332697606 2888 NA FF|FT RNA PROCESSING NUCLEUS U2-snRNP associated splicing factor with similarity to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM) mRNA splicing, via spliceosome RNA binding U2 snRNP|U2-type prespliceosome
YDL145C YDL145C COP1 het Verified -1.24476147100133 0.106609721329888 no 982 0.100804926890107 3049 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway retrograde vesicle-mediated transport, Golgi to ER|ER to Golgi vesicle-mediated transport ubiquitin binding COPI vesicle coat
YDR394W YDR394W RPT3 het Verified -1.24875271338575 0.105877767054076 no 983 0.151077701867454 2885 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS NUCLEUS One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|proteasome regulatory particle assembly|ubiquitin-dependent protein catabolic process ATPase activity proteasome regulatory particle, base subcomplex
YNL126W YNL126W SPC98 het Verified -1.25493684490058 0.104750843644764 no 984 0.171514152460778 2853 NA FF|FT CELL CYCLE|CYTOSKELETON ORGANIZATION NUCLEUS|CYTOSKELETON Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque microtubule nucleation|mitotic spindle organization in nucleus structural constituent of cytoskeleton outer plaque of spindle pole body|gamma-tubulin small complex, spindle pole body|inner plaque of spindle pole body
YMR260C YMR260C TIF11 het Verified -1.26492444881413 0.102949206085872 no 985 0.109855112642826 2993 NA FT TRANSLATION RIBOSOME Translation initiation factor eIF1A, essential protein that forms a complex with Sui1p (eIF1) and the 40S ribosomal subunit and scans for the start codon; C-terminus associates with Fun12p (eIF5B); N terminus interacts with eIF2 and eIF3 translational initiation double-stranded RNA binding|translation initiation factor activity ribosome
YJR017C YJR017C ESS1 het Verified -1.26514239604093 0.102910143714187 no 986 0.0858155905518518 3023 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CHROMATIN ORGANIZATION|PROTEOLYSIS|GENE SILENCING NUCLEUS Peptidylprolyl-cis/trans-isomerase (PPIase); specific for phosphorylated serine and threonine residues N-terminal to proline; regulates phosphorylation of the RNAP II large subunit (Rpo21p) C-terminal domain (CTD); associates with phospho-Ser5 form of RNAP II in vivo; regulates phosphorylation of Ser7 within CTD; present along entire coding length of genes; represses initiation of CUTs; required for efficient termination of mRNA transcription and trimethylation of histone H3 termination of RNA polymerase II transcription|positive regulation of protein dephosphorylation|negative regulation of histone deacetylation|negative regulation of transcription from RNA polymerase II promoter|protein peptidyl-prolyl isomerization|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|Unknown|regulation of transcription involved in G1 phase of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription involved in G2/M-phase of mitotic cell cycle peptidyl-prolyl cis-trans isomerase activity|RNA polymerase II core binding nucleus
YLR347C YLR347C KAP95 het Verified -1.27482551704483 0.101185503420695 no 987 0.107723094919854 3019 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|LIPID METABOLISM ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE Karyopherin beta, forms a complex with Srp1p/Kap60p; interacts with nucleoporins to mediate nuclear import of NLS-containing cargo proteins via the nuclear pore complex; regulates PC biosynthesis; GDP-to-GTP exchange factor for Gsp1p protein targeting to membrane|regulation of protein desumoylation|protein import into nucleus|phosphatidylcholine biosynthetic process|nuclear pore complex assembly protein transporter activity|Ran guanyl-nucleotide exchange factor activity integral to membrane|nuclear exosome (RNase complex)|nuclear pore|cytoplasm
YHL015W YHL015W RPS20 het Verified -1.2754241717942 0.101079573807689 no 988 0.126706932377989 2888 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10 cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit
YPL237W YPL237W SUI3 het Verified -1.2898730143692 0.0985473758462438 no 989 0.142310596140119 2854 NA FT TRANSLATION RIBOSOME Beta subunit of the translation initiation factor eIF2, involved in the identification of the start codon; proposed to be involved in mRNA binding translational initiation translation initiation factor activity multi-eIF complex|ribosome|eukaryotic translation initiation factor 2 complex
YPL122C YPL122C TFB2 het Verified -1.29641312154564 0.097416596908268 no 990 0.0983581935579044 3049 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION NUCLEUS RNA POL II, HOLOENZYME Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair, similar to 52 kDa subunit of human TFIIH phosphorylation of RNA polymerase II C-terminal domain|nucleotide-excision repair|transcription from RNA polymerase II promoter double-stranded DNA binding|core RNA polymerase binding transcription factor activity core TFIIH complex|holo TFIIH complex|nucleotide-excision repair factor 3 complex
YDR190C YDR190C RVB1 het Verified -1.30435238019358 0.0960567317672594 no 991 0.0819420123099784 3125 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME ATP-dependent DNA helicase, also known as pontin; member of the AAA+ and RuvB-like protein families; similar to Rvb2p; conserved component of multiple complexes including the INO80 complex, the Swr1 complex, and the R2TP complex (Rvb1-Rvb2-Tah1-Pih1); involved in multiple processes such as chromatin remodeling, box C/D snoRNP assembly, and RNA polymerase II assembly regulation of transcription from RNA polymerase II promoter|box C/D snoRNP assembly|chromatin remodeling|histone exchange ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 3'-5' DNA helicase activity ASTRA complex|R2TP complex|Swr1 complex|nucleus|Ino80 complex
YMR314W YMR314W PRE5 het Verified -1.30545309712884 0.095869304112551 no 992 0.108763021047463 2995 NA FT PROTEOLYSIS ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process molecular_function mitochondrion|proteasome core complex, alpha-subunit complex|proteasome storage granule|nucleus|nuclear outer membrane-endoplasmic reticulum membrane network
YJL031C YJL031C BET4 het Verified -1.3271877995892 0.0922232836024719 no 993 0.131319766236862 2973 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN PRENYLATION Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p protein targeting to membrane|protein geranylgeranylation|ER to Golgi vesicle-mediated transport Rab geranylgeranyltransferase activity Rab-protein geranylgeranyltransferase complex
YJL074C YJL074C SMC3 het Verified -1.33662259892031 0.0906729292527209 no 994 0.0539775378818403 3170 NA FT CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Subunit of the multiprotein cohesin complex required for sister chromatid cohesion in mitotic cells; also required, with Rec8p, for cohesion and recombination during meiosis; phylogenetically conserved SMC chromosomal ATPase family member synaptonemal complex assembly|ascospore formation|reciprocal meiotic recombination|mitotic sister chromatid cohesion|meiotic sister chromatid cohesion ATPase activity nucleus|nuclear mitotic cohesin complex
YIL106W YIL106W MOB1 het Verified -1.34650938841158 0.0890691473364467 no 995 0.0969604687891952 3052 NA FT CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION NUCLEUS|SITE OF POLARIZED GROWTH|CHROMOSOME|CYTOSKELETON Component of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required for cytokinesis and cell separation; component of the CCR4 transcriptional complex; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress regulation of exit from mitosis|protein phosphorylation kinase regulator activity spindle pole body|cellular bud neck
YGR218W YGR218W CRM1 het Verified -1.35401129196019 0.0878663875974635 no 996 0.0909763423826415 3035 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION NUCLEUS|CHROMOSOME|CYTOSKELETON KINETOCHORE Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus; exportin mRNA export from nucleus|protein export from nucleus|protein localization to kinetochore|ribosomal large subunit export from nucleus protein transporter activity integral to membrane|nucleus|spindle pole body|kinetochore
YMR200W YMR200W ROT1 het Verified -1.35789571074923 0.0872483893059784 no 997 0.0730561791721464 3123 NA FT CELL CYCLE|SIGNALING|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM|CYTOSKELETON ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Molecular chaperone involved in protein folding in the ER; mutation causes defects in cell wall synthesis and in lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations; involved in N-linked glycosylation and O-mannosylation budding cell apical bud growth|cell cycle cytokinesis|establishment or maintenance of actin cytoskeleton polarity|protein O-linked mannosylation|endoplasmic reticulum unfolded protein response|protein folding|fungal-type cell wall biogenesis|'de novo' protein folding|protein N-linked glycosylation unfolded protein binding endoplasmic reticulum|endoplasmic reticulum membrane
YMR093W YMR093W UTP15 het Verified -1.36421621823112 0.0862497626428599 no 998 0.104604552920383 2957 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS|CHROMOSOME Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA positive regulation of transcription from RNA polymerase I promoter|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) snoRNA binding small-subunit processome|rDNA heterochromatin|nucleolus|t-UTP complex|90S preribosome
YPR010C YPR010C RPA135 het Verified -1.36770133797746 0.0857027904877727 no 999 0.0700276142869156 3151 NA FT NUCLEUS RNA polymerase I second largest subunit A135 transcription of nuclear large rRNA transcript from RNA polymerase I promoter DNA-directed RNA polymerase activity DNA-directed RNA polymerase I complex
YDR041W YDR041W RSM10 het Verified -1.37634725111373 0.084357075283117 no 1000 0.0871906061891068 3050 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YDL193W YDL193W NUS1 het Verified -1.41070860560692 0.0791652762363953 no 1001 0.128301664343657 2925 NA FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Putative prenyltransferase, required for cell viability; proposed to be involved in protein trafficking because tet-repressible mutant shows accumulation of hypoglycosylated forms of CPY protein glycosylation prenyltransferase activity nuclear envelope|lipid particle|endoplasmic reticulum
YPL063W YPL063W TIM50 het Verified -1.41174241493542 0.0790129097936938 no 1002 0.0818370925579565 3064 NA FT PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); acts as receptor for the TIM23 complex guiding incoming precursors from the TOM complex; may control the gating of the Tim23p-Tim17p channel protein import into mitochondrial matrix mitochondrion targeting sequence binding|protein channel activity mitochondrion|mitochondrial inner membrane presequence translocase complex
YPR016C YPR016C TIF6 het Verified -1.41513586720947 0.0785143318693058 no 1003 0.130273341618452 2949 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION NUCLEUS Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits ribosomal subunit export from nucleus|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal large subunit biogenesis|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA processing ribosomal large subunit binding nucleolus|nucleus|preribosome, large subunit precursor|cytoplasm
YER018C YER018C SPC25 het Verified -1.41542979454413 0.0784712595175592 no 1004 0.070095547226081 3111 NA FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME KINETOCHORE Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering microtubule nucleation|chromosome segregation structural constituent of cytoskeleton Ndc80 complex|condensed nuclear chromosome kinetochore|condensed nuclear chromosome, centromeric region
YDR449C YDR449C UTP6 het Verified -1.42495619462871 0.0770849320485581 no 1005 0.125980279420936 2912 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) snoRNA binding small-subunit processome|nucleolus|Pwp2p-containing subcomplex of 90S preribosome|90S preribosome
YDL152W_d YDL152W YDL152W het Dubious -1.43241880963144 0.0760119993031213 no 1006 0.155182621448776 2844 NA FF Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SAS10/YDL153C, a component of the small ribosomal subunit processosome Unknown Unknown Unknown
YLR132C YLR132C USB1 het Verified -1.43430623603408 0.075742445758818 no 1007 0.0542818798213518 3170 NA FT RNA PROCESSING NUCLEUS|MITOCHONDRION Putative phosphodiesterase specific for U6 snRNA 3' end modification; trims the 3' poly(u) tract to leave a terminal 3' phosphate; human homolog, hUSB1 (aka C16orf57) produces a 2',3' cyclic phosphate; mutations in hUSB1 are associated with a rare skin condition (OMIM 604173); essential protein that localizes to the nucleus and mitochondria; overexpression suppresses the respiratory defects of oxa1 and mtf2 mutants U6 snRNA 3'-end processing phosphoric diester hydrolase activity mitochondrion|nucleus|cytoplasm
YGL142C YGL142C GPI10 het Verified -1.43534234470218 0.0755947833788581 no 1008 0.0622496332427869 3126 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Integral membrane protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; putative alpha 1,2 mannosyltransferase required for addition of the third mannose onto the GPI core structure; human PIG-Bp is a functional homolog GPI anchor biosynthetic process dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity integral to membrane
YKL082C YKL082C RRP14 het Verified -1.44457390440934 0.0742888035379929 no 1009 0.05710364975161 3149 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS RIBOSOME Essential protein, constituent of 66S pre-ribosomal particles; interacts with proteins involved in ribosomal biogenesis and cell polarity; member of the SURF-6 family ribosomal small subunit biogenesis|ribosomal large subunit biogenesis molecular_function cytosolic large ribosomal subunit|nucleolus
YMR134W YMR134W ERG29 het Verified -1.44792486157801 0.0738190328655587 no 1010 0.0758185158685726 3044 NA FT LIPID METABOLISM|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Protein of unknown function that may be involved in iron metabolism; mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p; shows localization to the ER; highly conserved in ascomycetes cellular iron ion homeostasis|mitochondrion organization molecular_function nuclear envelope|endoplasmic reticulum|cytoplasm
YDR054C YDR054C CDC34 het Verified -1.45630054092779 0.0726547780377898 no 1011 0.0419959534215467 3218 NA FT CELL CYCLE|CELL DIVISION|PROTEOLYSIS NUCLEUS UBIQUITIN LIGASE COMPLEX Ubiquitin-conjugating enzyme (E2); catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation; protein abundance increases in response to DNA replication stress G2/M transition of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|protein autoubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|G1/S transition of mitotic cell cycle|protein polyubiquitination ubiquitin-protein ligase activity|protein homodimerization activity SCF ubiquitin ligase complex|nucleus|cytoplasm
YGR024C YGR024C THG1 het Verified -1.46597443956609 0.0713276252239229 no 1012 0.0662915026530046 3129 NA FT RNA PROCESSING NUCLEUS tRNAHis guanylyltransferase, adds a guanosine residue to the 5' end of tRNAHis after transcription and RNase P cleavage; couples nuclear division and migration to cell budding and cytokinesis; essential enzyme conserved among eukaryotes tRNA modification tRNA guanylyltransferase activity nucleus|cytoplasm
YIR010W YIR010W DSN1 het Verified -1.48079677242046 0.0693303684359058 no 1013 0.06354617754337 3159 NA FT CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME|CYTOSKELETON KINETOCHORE Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; important for chromosome segregation chromosome segregation molecular_function nuclear MIS12/MIND type complex|kinetochore|spindle pole
YGL171W YGL171W ROK1 het Verified -1.48568251334634 0.0686815590509127 no 1014 0.0725782434485056 3136 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|RNA LOCALIZATION NUCLEUS RNA-dependent ATPase; involved in pre-rRNA processing at sites A0, A1, and A2, and in control of cell cycle progression; contains two upstream open reading frames (uORFs) in 5' untranslated region which regulate translation endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|snoRNA localization RNA-dependent ATPase activity nucleolus|90S preribosome
YJR041C YJR041C URB2 het Verified -1.48905007200504 0.0682370919126678 no 1015 0.0519755527835873 3180 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Nucleolar protein required for normal metabolism of the rRNA primary transcript, proposed to be involved in ribosome biogenesis rRNA metabolic process|ribosome biogenesis molecular_function nucleolus
YNL282W YNL282W POP3 het Verified -1.4904465963599 0.0680534241768818 no 1016 0.0582495826448298 3182 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs tRNA processing|intronic box C/D snoRNA processing|mRNA cleavage|rRNA processing ribonuclease MRP activity|ribonuclease P activity nucleolar ribonuclease P complex|ribonuclease MRP complex
YBR247C YBR247C ENP1 het Verified -1.49672326203079 0.0672326404148324 no 1017 0.0659956852285441 3120 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Protein associated with U3 and U14 snoRNAs, required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA processing snoRNA binding preribosome, small subunit precursor|nucleolus|nucleus|cytoplasm|90S preribosome
YOR203W_d YOR203W YOR203W het Dubious -1.49679938255362 0.0672227335082349 no 1018 0.0686528306248596 3099 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps 5' end of essential DED1 gene required for translation initiation Unknown Unknown Unknown
YLR147C YLR147C SMD3 het Verified -1.49912666308059 0.0669203878738273 no 1019 0.0782347905386601 3067 NA FT RNA PROCESSING NUCLEUS Core Sm protein Sm D3; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D3 mRNA splicing, via spliceosome mRNA binding commitment complex|U1 snRNP|U2-type prespliceosome|U4/U6 x U5 tri-snRNP complex|U5 snRNP
YIL083C YIL083C CAB2 het Verified -1.50516629673819 0.0661406638907102 no 1020 0.0593828361929145 3128 NA FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM NUCLEUS Probable phosphopantothenoylcysteine synthetase (PPCS), which catalyzes the second step of coenzyme A biosynthesis from pantothenate; null mutant lethality is complemented by E. coli coaBC (encoding a bifunctional enzyme with PPCS activity) coenzyme A biosynthetic process phosphopantothenate--cysteine ligase activity nucleus|cytoplasm
YOR098C YOR098C NUP1 het Verified -1.51155953903425 0.0653229756724288 no 1021 0.0393073787264564 3229 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC; both NUP1 and NUP60 are homologous to human NUP153 poly(A)+ mRNA export from nucleus|NLS-bearing substrate import into nucleus|ribosomal large subunit export from nucleus|protein import into nucleus|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery nucleocytoplasmic transporter activity|structural constituent of nuclear pore nuclear pore central transport channel|nuclear pore nuclear basket|integral to membrane|nuclear pore
YOL021C YOL021C DIS3 het Verified -1.51644028373566 0.0647040297082648 no 1022 0.112209538726867 2969 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS|MITOCHONDRION Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3; protein abundance increases in response to DNA replication stress nuclear mRNA surveillance|nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nonfunctional rRNA decay|nuclear polyadenylation-dependent mRNA catabolic process|rRNA catabolic process|polyadenylation-dependent snoRNA 3'-end processing|nuclear-transcribed mRNA catabolic process, non-stop decay|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ncRNA 3'-end processing 3'-5'-exoribonuclease activity|endoribonuclease activity|tRNA binding mitochondrion|nucleolus|nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)
YHR007C YHR007C ERG11 het Verified -1.51942204910011 0.0643281477154628 no 1023 0.142306743946494 2959 NA FF|FT LIPID METABOLISM|OXIDATION-REDUCTION PROCESS ENDOPLASMIC RETICULUM Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p ergosterol biosynthetic process sterol 14-demethylase activity endoplasmic reticulum
YKL059C YKL059C MPE1 het Verified -1.5213829984431 0.0640818764204738 no 1024 0.0529771002985727 3204 NA FT RNA PROCESSING NUCLEUS Essential conserved subunit of CPF (cleavage and polyadenylation factor), plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA, contains a putative RNA-binding zinc knuckle motif mRNA cleavage|mRNA polyadenylation RNA binding mRNA cleavage and polyadenylation specificity factor complex
YNL137C YNL137C NAM9 het Verified -1.58610062094735 0.0563582430224878 no 1025 0.0487734269220566 3169 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal component of the small subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YPR176C YPR176C BET2 het Verified -1.61768638910458 0.0528651003673274 no 1026 0.0209501818127659 3253 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN PRENYLATION Beta subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p protein targeting to membrane|protein geranylgeranylation|ER to Golgi vesicle-mediated transport Rab geranylgeranyltransferase activity Rab-protein geranylgeranyltransferase complex
YGR264C YGR264C MES1 het Verified -1.63135594851622 0.0514076171363275 no 1027 0.0576327928910589 3140 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs methionyl-tRNA aminoacylation methionine-tRNA ligase activity methionyl glutamyl tRNA synthetase complex|cytoplasm
YLR129W YLR129W DIP2 het Verified -1.63187888307732 0.0513525016836868 no 1028 0.0368842731496553 3191 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Nucleolar protein, specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) snoRNA binding small-subunit processome|nucleolus|Pwp2p-containing subcomplex of 90S preribosome|90S preribosome
YPR107C YPR107C YTH1 het Verified -1.64259122604706 0.0502337686608538 no 1029 0.131133711586511 2987 NA FF|FT RNA PROCESSING NUCLEUS Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation mRNA cleavage|mRNA polyadenylation RNA binding mRNA cleavage and polyadenylation specificity factor complex
YML092C YML092C PRE8 het Verified -1.66117755981275 0.0483388955200631 no 1030 0.0692603002695317 3078 NA FF|FT PROTEOLYSIS ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION Alpha 2 subunit of the 20S proteasome proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process molecular_function mitochondrion|proteasome core complex, alpha-subunit complex|proteasome storage granule|nucleus|nuclear outer membrane-endoplasmic reticulum membrane network
YBL041W YBL041W PRE7 het Verified -1.68253806786975 0.0462322747828013 no 1031 0.0498108430641251 3175 NA FT PROTEOLYSIS ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Beta 6 subunit of the 20S proteasome proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process molecular_function nucleus|proteasome storage granule|endoplasmic reticulum membrane|proteasome core complex, beta-subunit complex
YLR291C YLR291C GCD7 het Verified -1.68648369756515 0.0458513362461764 no 1032 0.043864244384151 3209 NA FT TRANSLATION MITOCHONDRION Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression regulation of translational initiation enzyme regulator activity|translation initiation factor activity|guanyl-nucleotide exchange factor activity mitochondrion|eukaryotic translation initiation factor 2B complex|guanyl-nucleotide exchange factor complex
YNL260C YNL260C LTO1 het Verified -1.70090645828329 0.0444802768566925 no 1033 0.0283659474021698 3266 NA FT NUCLEUS Essential protein that forms a complex with Rli1p and Yae1p; ortholog of human ORAOV1, which is overexpressed in solid tumors; inviability of null mutant under standard conditions is complemented by overexpression of ORAOV1; essential for growth under standard (aerobic) conditions but not under anaerobic conditions; may have a role in protection of ribosomal assembly and function from damage due to reactive oxygen species biological_process molecular_function nucleus|cytoplasm
YBL020W YBL020W RFT1 het Verified -1.71406626198996 0.0432582785641396 no 1034 0.0636577429142667 3159 NA FT MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Essential integral membrane protein that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane but is not the flippase; mutation is suppressed by expression of human p53 protein glycolipid translocation molecular_function|glycolipid-translocating activity integral to membrane|endoplasmic reticulum membrane
YGR095C YGR095C RRP46 het Verified -1.71735649307564 0.042957027909427 no 1035 0.0667966052785283 3106 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5) nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear polyadenylation-dependent mRNA catabolic process|nonfunctional rRNA decay|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|polyadenylation-dependent snoRNA 3'-end processing|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|nuclear-transcribed mRNA catabolic process, non-stop decay|ncRNA 3'-end processing molecular_function nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)
YDR016C YDR016C DAD1 het Verified -1.72377778675373 0.042373983080368 no 1036 0.0561416547266489 3170 NA FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME|CYTOSKELETON KINETOCHORE Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis mitotic spindle organization in nucleus|regulation of microtubule polymerization or depolymerization microtubule binding|structural constituent of cytoskeleton condensed nuclear chromosome kinetochore|DASH complex|spindle
YOL034W YOL034W SMC5 het Verified -1.73889375524892 0.0410267264365328 no 1037 0.0247726587109348 3229 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; binds single-stranded DNA and has ATPase activity; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair DNA repair|resolution of recombination intermediates|recombinational repair|rDNA separation damaged DNA binding|single-stranded DNA binding|ATPase activity Smc5-Smc6 complex|nucleus
YHR040W YHR040W BCD1 het Verified -1.74608885267719 0.0403977567595216 no 1038 0.0247048166652685 3262 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS NUCLEUS Essential protein required for the accumulation of box C/D snoRNA snoRNA metabolic process nucleic acid binding nucleus|cytoplasm
YOR207C YOR207C RET1 het Verified -1.75080723774021 0.0399895597338226 no 1039 0.0527333839695525 3165 NA FF|FT NUCLEUS Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs tRNA transcription from RNA polymerase III promoter DNA-directed RNA polymerase activity DNA-directed RNA polymerase III complex
YMR290W-A_d YMR290W-A YMR290W-A het Dubious -1.75680894880271 0.0394751896298667 no 1040 0.0810905787805139 3131 NA FF Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase Unknown Unknown Unknown
YPR178W YPR178W PRP4 het Verified -1.79600267906097 0.0362470454766966 no 1041 0.0259847611642955 3236 NA FT RNA PROCESSING NUCLEUS Splicing factor, component of the U4/U6-U5 snRNP complex mRNA splicing, via spliceosome molecular_function U4/U6 x U5 tri-snRNP complex
YDR246W YDR246W TRS23 het Verified -1.80142617404835 0.0358178668847496 no 1042 0.0133635801148088 3283 NA FT VESICLE-MEDIATED TRANSPORT ENDOPLASMIC RETICULUM|GOLGI APPARATUS One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic; human homolog is TRAPPC4 chromosome organization|ER to Golgi vesicle-mediated transport Rab guanyl-nucleotide exchange factor activity TRAPP complex
YJL086C_d YJL086C YJL086C het Dubious -1.80215629296102 0.0357604095247733 no 1043 0.0810646964787781 3048 NA FF Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL085W/EXO70 and YJL087C/TRL1 Unknown Unknown Unknown
YGR005C YGR005C TFG2 het Verified -1.80730395938383 0.035357449519779 no 1044 0.0267947404057131 3241 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30 transcriptional start site selection at RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|promoter clearance from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter core RNA polymerase II binding transcription factor activity|core RNA polymerase II recruiting transcription factor activity transcription factor TFIIF complex
YDL207W YDL207W GLE1 het Verified -1.81029402831877 0.0351251013138061 no 1045 0.0304209297880103 3274 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION NUCLEAR PORE Cytoplasmic nucleoporin required for polyadenylated RNA export; not essential for protein import; contains a nuclear export signal; when bound to inositol hexakisphosphate (IP6), functions as an activator for the Dbp5p ATPase activity at the nuclear pore complex during mRNA export poly(A)+ mRNA export from nucleus|mRNA export from nucleus|regulation of translational initiation|regulation of translational termination translation initiation factor binding|inositol hexakisphosphate binding|phospholipid binding|enzyme activator activity mitochondrion|integral to membrane|nuclear pore cytoplasmic filaments|nuclear pore|cytoplasm
YOR210W YOR210W RPB10 het Verified -1.83254625042796 0.0334350388450107 no 1046 0.0646575832405208 3099 NA FF|FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III transcription from RNA polymerase I promoter|transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter RNA-directed RNA polymerase activity|DNA-directed RNA polymerase activity DNA-directed RNA polymerase I complex|DNA-directed RNA polymerase III complex|DNA-directed RNA polymerase II, core complex
YPL143W YPL143W RPL33A het Verified -1.84942782349694 0.0321980304524058 no 1047 0.0288834809565968 3211 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L33A; N-terminally acetylated; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33A has a paralog, RPL33B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YBR124W_d YBR124W YBR124W het Dubious -1.85195533866869 0.0320161182071812 no 1048 0.0296892419281895 3224 NA Putative protein of unknown function Unknown Unknown Unknown
YJL035C YJL035C TAD2 het Verified -1.86463525487537 0.0311162738462438 no 1049 0.0165034601802932 3253 NA FT RNA PROCESSING NUCLEUS Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNAs tRNA modification tRNA-specific adenosine deaminase activity nucleus|cytoplasm
YDR526C_d YDR526C YDR526C het Dubious -1.87001180434205 0.0307410893239529 no 1050 0.0649150619300823 3105 NA FF Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPL011C YPL011C TAF3 het Verified -1.88695001110537 0.029583524788109 no 1051 0.0213767550513213 3265 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME TFIID subunit (47 kDa), involved in promoter binding and RNA polymerase II transcription initiation RNA polymerase II transcriptional preinitiation complex assembly|transcription from RNA polymerase II promoter chromatin binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly transcription factor TFIID complex
YOL139C YOL139C CDC33 het Verified -1.97473579970555 0.024149069013102 no 1052 0.0171718237532481 3287 NA FT CELL CYCLE|TRANSLATION NUCLEUS RIBOSOME mRNA cap binding protein and translation initiation factor eIF4E; the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with translation initiation factor eIF4G (Tif4631p or Tif4632p); protein abundance increases in response to DNA replication stress; mutants are defective for adhesion and pseudohyphal growth regulation of cell cycle|translational initiation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay phosphatidylinositol-3-phosphate binding|translation initiation factor activity ribosome|nucleus|eukaryotic translation initiation factor 4F complex|cytoplasmic stress granule|cytoplasm
YJR013W YJR013W GPI14 het Verified -2.00013920144967 0.022742617373484 no 1053 0.024072138746923 3246 NA FT LIPID METABOLISM|CELL WALL ORG/BIOGENESIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M fungal-type cell wall organization|GPI anchor biosynthetic process mannosyltransferase activity integral to membrane|endoplasmic reticulum membrane
YGR115C_d YGR115C YGR115C het Dubious -2.01900882231863 0.0217431512752881 no 1054 0.0490907427397185 3185 NA FF Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified and essential ORF SPT6/YGR115C Unknown Unknown Unknown
YDL055C YDL055C PSA1 het Verified -2.02665368797553 0.0213489209194064 no 1055 0.0171334968770315 3288 NA FT CELL CYCLE|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure protein glycosylation|cell wall mannoprotein biosynthetic process|GDP-mannose biosynthetic process mannose-1-phosphate guanylyltransferase activity cytoplasm
YOL069W YOL069W NUF2 het Verified -2.04585831783131 0.020385156169991 no 1056 0.0207500635241262 3257 NA FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME|CYTOSKELETON KINETOCHORE Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering microtubule nucleation|chromosome segregation structural constituent of cytoskeleton spindle microtubule|Ndc80 complex|condensed nuclear chromosome kinetochore|condensed nuclear chromosome, centromeric region|spindle pole body
YDL058W YDL058W USO1 het Verified -2.05343803266343 0.0200150569376279 no 1057 0.0209118650297544 3293 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS|CYTOSKELETON Essential protein involved in the vesicle-mediated ER to Golgi transport step of secretion; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex Golgi vesicle docking|ER to Golgi vesicle-mediated transport|SNARE complex assembly molecular_function integral to membrane|ER to Golgi transport vesicle membrane|Golgi membrane
YLL035W YLL035W GRC3 het Verified -2.06708096290565 0.0193632628037647 no 1058 0.0101741198507018 3307 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS|CHROMOSOME Polynucleotide kinase present on rDNA that is required for efficient transcription termination by RNA polymerase I; required for cell growth; mRNA is cell-cycle regulated termination of RNA polymerase I transcription|rRNA processing polynucleotide 5'-hydroxyl-kinase activity nucleolar chromatin
YOL144W YOL144W NOP8 het Verified -2.07460602499344 0.0190115316283001 no 1059 0.0465772754587139 3172 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS NUCLEUS Nucleolar protein required for 60S ribosomal subunit biogenesis ribosomal large subunit biogenesis molecular_function nucleolus
YPL218W YPL218W SAR1 het Verified -2.10904442725656 0.01747037349855 no 1060 0.0158559015418186 3275 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS GTPase, GTP-binding protein of the ARF family, component of COPII coat of vesicles; required for transport vesicle formation during ER to Golgi protein transport regulation of COPII vesicle coating GTPase activity COPII vesicle coat
YNL312W YNL312W RFA2 het Verified -2.12513344589759 0.0167877397434591 no 1061 0.00585290973838761 3323 NA FT PROTEIN LOCALIZATION|CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; protein abundance increases in response to DNA replication stress establishment of protein localization|telomere maintenance via telomerase|telomere maintenance via recombination|nucleotide-excision repair|DNA repair|mitotic recombination|heteroduplex formation|DNA unwinding involved in replication|reciprocal meiotic recombination|double-strand break repair via homologous recombination|DNA replication|protein ubiquitination double-stranded DNA binding|single-stranded DNA binding|sequence-specific DNA binding condensed nuclear chromosome|chromosome, telomeric region|DNA replication factor A complex
YOR169C_d YOR169C YOR169C het Dubious -2.14019274040915 0.0161695968096891 no 1062 0.0036752559792161 3318 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GLN4/YOR168W Unknown Unknown Unknown
YKL018W YKL018W SWD2 het Verified -2.24881061684184 0.0122622738109833 no 1063 0.0139681172231094 3299 NA FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination mRNA 3'-end processing|termination of RNA polymerase II transcription, exosome-dependent|histone H3-K4 methylation|termination of RNA polymerase II transcription, poly(A)-coupled|telomere maintenance|snoRNA 3'-end processing|histone H3-K79 methylation histone methyltransferase activity (H3-K4 specific) mRNA cleavage and polyadenylation specificity factor complex|Set1C/COMPASS complex
YPR175W YPR175W DPB2 het Verified -2.25439461119753 0.0120856770014228 no 1064 0.00319323138236294 3332 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Second largest subunit of DNA polymerase II (DNA polymerase epsilon), required for maintenance of fidelity of chromosomal replication; expression peaks at the G1/S phase boundary; Cdc28p substrate DNA-dependent DNA replication double-stranded DNA binding|single-stranded DNA binding|DNA-directed DNA polymerase activity nucleus|epsilon DNA polymerase complex|cytoplasm
YFR050C YFR050C PRE4 het Verified -2.28227441234063 0.0112365721188206 no 1065 0.0182813576472719 3249 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Beta 7 subunit of the 20S proteasome proteasome assembly|proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process molecular_function nucleus|proteasome storage granule|endoplasmic reticulum membrane|proteasome core complex, beta-subunit complex
YOR020C YOR020C HSP10 het Verified -2.29811787599598 0.0107775405517394 no 1066 0.0123597396552347 3288 NA FT MITOCHONDRION Mitochondrial matrix co-chaperonin that inhibits the ATPase activity of Hsp60p, a mitochondrial chaperonin; involved in protein folding and sorting in the mitochondria; 10 kD heat shock protein with similarity to E. coli groES protein folding|protein refolding unfolded protein binding|chaperone binding mitochondrion|mitochondrial matrix
YNL007C YNL007C SIS1 het Verified -2.31664740735048 0.0102614733337852 no 1067 0.00534334823750523 3315 NA FT CELL CYCLE|TRANSLATION NUCLEUS RIBOSOME Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p; not functionally redundant with Ydj1p due to due to substrate specificity; has similarity to bacterial DnaJ proteins; protein abundance increases in response to DNA replication stress protein folding|translational initiation unfolded protein binding cytosolic small ribosomal subunit
YDR189W YDR189W SLY1 het Verified -2.33585996702627 0.00974927050401734 no 1068 0.0122698127076862 3299 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Hydrophilic protein involved in vesicle trafficking between the ER and Golgi; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex retrograde vesicle-mediated transport, Golgi to ER|ER to Golgi vesicle-mediated transport|vesicle fusion with Golgi apparatus|positive regulation of SNARE complex assembly SNARE binding|syntaxin binding SNARE complex|endoplasmic reticulum|ER to Golgi transport vesicle|Golgi membrane
YDL150W YDL150W RPC53 het Verified -2.34965450800343 0.00939542176571572 no 1069 0.0553416722457647 3171 NA FF|FT NUCLEUS RNA polymerase III subunit C53 tRNA transcription from RNA polymerase III promoter DNA-directed RNA polymerase activity DNA-directed RNA polymerase III complex
YJL203W YJL203W PRP21 het Verified -2.35786551621852 0.00919017517826696 no 1070 0.00418090660567631 3332 NA FT RNA PROCESSING NUCLEUS Subunit of the SF3a splicing factor complex, required for spliceosome assembly mRNA splicing, via spliceosome RNA binding U2 snRNP|U2-type prespliceosome
YGR195W YGR195W SKI6 het Verified -2.39489130373745 0.00831264651465948 no 1071 0.00351248302140804 3314 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4) nuclear mRNA surveillance|U5 snRNA 3'-end processing|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent CUT catabolic process|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear polyadenylation-dependent mRNA catabolic process|nonfunctional rRNA decay|U4 snRNA 3'-end processing|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|rRNA catabolic process|polyadenylation-dependent snoRNA 3'-end processing|U1 snRNA 3'-end processing|nuclear-transcribed mRNA catabolic process, non-stop decay|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)
YBR243C YBR243C ALG7 het Verified -2.40280082318196 0.008135023226668 no 1072 0.00395973876160497 3305 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin protein N-linked glycosylation|aerobic respiration UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity UDP-N-acetylglucosamine transferase complex|integral to membrane
YCR052W YCR052W RSC6 het Verified -2.4731809716433 0.00669581550933847 no 1073 0.0664887300564217 3150 NA FF|FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION NUCLEUS RSC COMPLEX Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p nucleosome positioning|ATP-dependent chromatin remodeling|G2/M transition of mitotic cell cycle|G1 phase of mitotic cell cycle|nucleosome disassembly|positive regulation of transcription elongation from RNA polymerase II promoter DNA translocase activity RSC complex
YJL072C YJL072C PSF2 het Verified -2.49667876413613 0.00626812319337195 no 1074 0.00917716989849553 3308 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery double-strand break repair via break-induced replication|DNA-dependent DNA replication molecular_function GINS complex|replication fork protection complex|nuclear replication fork|nucleus|DNA replication preinitiation complex
YNR003C YNR003C RPC34 het Verified -2.52569627164645 0.00577346308933719 no 1075 0.00236867655037427 3337 NA FT NUCLEUS|MITOCHONDRION RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex tRNA transcription from RNA polymerase III promoter DNA-directed RNA polymerase activity mitochondrion|DNA-directed RNA polymerase III complex|nucleus|cytoplasm
YNL112W YNL112W DBP2 het Verified -2.52711753698766 0.00575015037629451 no 1076 0.0140171505895438 3270 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS|MITOCHONDRION ATP-dependent RNA helicase of the DEAD-box protein family; has a strong preference for dsRNA; involved mRNA decay and rRNA processing; may be involved in suppression of transcription from cryptic initiation sites nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|rRNA processing RNA helicase activity mitochondrion|nucleus|cytoplasm
YKL099C YKL099C UTP11 het Verified -2.53112327350245 0.00568489406253917 no 1077 0.00285307124926217 3334 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function small-subunit processome|nucleolus
YDR510W YDR510W SMT3 het Verified -2.57970453352405 0.00494424404926765 no 1078 0.00219087819743025 3336 NA FT NUCLEUS|CHROMOSOME|CYTOSKELETON Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics; phosphorylated at Ser2 protein sumoylation protein tag condensed nuclear chromosome|nucleus|septin ring
YBR087W YBR087W RFC5 het Verified -2.630203801087 0.00426668473823066 no 1079 0.00175847266717435 3344 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon mismatch repair|sister chromatid cohesion|leading strand elongation DNA clamp loader activity Elg1 RFC-like complex|Rad17 RFC-like complex|DNA replication factor C complex|Ctf18 RFC-like complex
YPR034W YPR034W ARP7 het Verified -2.68621886499866 0.00361328672743102 no 1080 0.0308165842959613 3247 NA FF|FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS RSC COMPLEX Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation nucleosome mobilization|ATP-dependent chromatin remodeling|chromatin organization|nucleosome disassembly|transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter DNA translocase activity RSC complex|SWI/SNF complex|nucleus
YOL022C YOL022C TSR4 het Verified -2.75239343740673 0.00295806985387189 no 1081 0.000777515195646692 3324 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS Cytoplasmic protein required for correct processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; essential gene in S288C background but not in CEN.PK2 maturation of SSU-rRNA molecular_function cytoplasm
YER012W YER012W PRE1 het Verified -2.75751945879725 0.00291208733747518 no 1082 0.00859543202681078 3280 NA FT PROTEOLYSIS ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-independent protein catabolic process endopeptidase activator activity proteasome storage granule|nucleus|endoplasmic reticulum membrane|proteasome core complex, beta-subunit complex
YGR119C YGR119C NUP57 het Verified -2.79110231786314 0.00262644320600277 no 1083 0.0109743008434992 3307 NA FT PROTEIN LOCALIZATION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup49p) NLS-bearing substrate import into nucleus|protein import into nucleus|nuclear pore organization|protein targeting to nuclear inner membrane nucleocytoplasmic transporter activity|structural constituent of nuclear pore nuclear pore central transport channel|integral to membrane|nuclear pore
YLR197W YLR197W NOP56 het Verified -2.83973775078849 0.00225753177393747 no 1084 0.0259475064869539 3237 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects rRNA modification|rRNA processing molecular_function box C/D snoRNP complex|small-subunit processome|nucleolus|nucleus|90S preribosome
YNR053C YNR053C NOG2 het Verified -2.84767973140381 0.00220196094744532 no 1085 0.00289967561953498 3325 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS NUCLEUS Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation ribosomal large subunit export from nucleus GTPase activity nucleoplasm|nucleolus|nucleus|preribosome, large subunit precursor
YHR036W YHR036W BRL1 het Verified -3.02816056133444 0.00123023659987921 no 1086 0.0062493761762692 3313 NA FF|FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export mRNA export from nucleus|protein export from nucleus|nuclear envelope organization molecular_function nuclear envelope|endoplasmic reticulum
YLR141W YLR141W RRN5 het Verified -3.03804037494211 0.00119061024137867 no 1087 0.00070900091858159 3341 NA FT CHROMATIN ORGANIZATION NUCLEUS Protein involved in transcription of rDNA by RNA polymerase I; transcription factor, member of UAF (upstream activation factor) family along with Rrn9p and Rrn10p transcription of nuclear large rRNA transcript from RNA polymerase I promoter|chromatin organization RNA polymerase I upstream control element sequence-specific DNA binding transcription factor activity nucleolus|RNA polymerase I upstream activating factor complex
YLR002C YLR002C NOC3 het Verified -3.04345510888695 0.00116939166269662 no 1088 0.000343117925159235 3346 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|CELL DIVISION NUCLEUS Component of a nuclear complex with Noc2p and pre-replicative complexes; the Noc2p-Noc3p complex binds to 66S ribosomal precursors to mediate their maturation and intranuclear transport; binds to chromatin at active replication origins, and is required for pre-RC formation and maintenance during DNA replication licensing rRNA processing|DNA replication initiation chromatin binding nucleoplasm|nucleolus|Noc2p-Noc3p complex|nucleus
YOR204W YOR204W DED1 het Verified -3.2234944480447 0.000633183766820367 yes 1089 0.00152561267253997 3340 NA FT TRANSLATION ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, required for translation initiation of all yeast mRNAs; mutations in human DEAD-box DBY are a frequent cause of male infertility translational initiation RNA strand annealing activity|ATP-dependent RNA helicase activity cytoplasm
YBR192W YBR192W RIM2 het Verified -3.33512731486652 0.00042630177087722 yes 1090 0.00166469874161562 3347 NA FF|FT ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS MITOCHONDRION Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family pyrimidine nucleotide transport|mitochondrial genome maintenance|transmembrane transport pyrimidine nucleotide transmembrane transporter activity|transporter activity mitochondrion|integral to membrane
YCR054C YCR054C CTR86 het Verified -3.88093455114686 5.20279215385581e-05 yes 1091 5.33059122610481e-06 3351 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Essential protein of unknown function; with orthologs in Ashbya gossypii and Candida albicans; similar to human ATXN10, mutations in which cause spinocerebellar ataxia type 10; codon usage corresponds to that observed for yeast genes expressed at low levels; relative distribution to the nucleus increases upon DNA replication stress biological_process molecular_function cytoplasm
YGR251W YGR251W NOP19 het Verified -4.20642116832308 1.29723262742529e-05 yes 1092 3.32343611427126e-06 3350 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Ribosome biogenesis factor; nucleolar protein associated with pre-rRNA components of the 90S preribosome, required for cleavage of pre-rRNA at A0, A1 and A2 sites; interacts with RNA helicase Dhr2p and RNA helicase-like protein Utp25p; required for incorporation of Utp25p into preribosomes endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function nucleoplasm|nucleolus|nucleus|90S preribosome
YJR076C YJR076C CDC11 het Verified -4.33111398896394 7.41784248591831e-06 yes 1093 1.3375511420709e-05 3346 NA FT CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION SITE OF POLARIZED GROWTH|CYTOSKELETON Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells maintenance of cell polarity|cell cycle cytokinesis|positive regulation of protein kinase activity structural molecule activity|GTP binding|1-phosphatidylinositol binding spindle microtubule|septin complex|prospore membrane|ascospore wall|mating projection base|meiotic spindle|cellular bud neck septin ring|septin filament array|cytoplasmic microtubule|mating projection tip
YLR249W YLR249W YEF3 het Verified -4.57997387657665 2.32517005136412e-06 yes 1094 8.03542712819931e-07 3353 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|NUCLEOTIDE METABOLISM RIBOSOME Gamma subunit of translational elongation factor eEF1B; stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex; contains two ABC cassettes; binds and hydrolyzes ATP; YEF3 has a paralog, HEF3, that arose from the whole genome duplication translational elongation|translational termination ATPase activity|translation elongation factor activity cytosolic ribosome|ribosome
YNR035C YNR035C ARC35 het Verified -4.7413224120452 1.06163862706081e-06 yes 1095 2.80633479441735e-05 3351 NA FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION CYTOSKELETON Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin mitochondrion inheritance|receptor-mediated endocytosis|microtubule cytoskeleton organization|actin cytoskeleton organization structural molecule activity cytosol|Arp2/3 protein complex