strainid orf gene zyg qualifier SGTC_2787|5284540.score SGTC_2787|5284540.expt.zyg.pval SGTC_2787|5284540.expt.zyg.significant SGTC_2787|5284540.expt.zyg.rank strain.pval strain.rank clearance Fclass Fterms.BP Fterms.CC Fterms.complex description GO_process GO_function GO_component
YHL032C YHL032C GUT1 hom Verified 13.9564667038069 1.43664643170891e-44 yes 1 6.4319696573149e-42 1 NA FT CARBOHYDRATE METABOLISM MITOCHONDRION Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p glycerol metabolic process glycerol kinase activity mitochondrion|cytoplasm
YDL020C YDL020C RPN4 hom Verified 11.4239845511836 1.58671653365707e-30 yes 2 5.65840185781247e-08 56 NA FF|FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|PROTEOLYSIS NUCLEUS Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance|regulation of DNA repair|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YPL207W YPL207W TYW1 hom Verified 6.36120642967166 1.00087600565356e-10 yes 3 7.18943147267703e-11 3 NA FT RNA PROCESSING|OXIDATION-REDUCTION PROCESS ENDOPLASMIC RETICULUM Iron-sulfer protein required for synthesis of Wybutosine modified tRNA; Wybutosine is a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions; induction by Yap5p in response to iron provides protection from high iron toxicity; overexpression results in increased cellular iron wybutosine biosynthetic process molecular_function endoplasmic reticulum
YLR099C YLR099C ICT1 hom Verified 6.34009519545262 1.14811618219368e-10 yes 4 1.66205261037309e-10 3 NA FT KETONE METABOLISM|LIPID METABOLISM Lysophosphatidic acid acyltransferase; responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stress; ICT1 has a paralog, ECM18, that arose from the whole genome duplication phosphatidic acid biosynthetic process lysophosphatidic acid acyltransferase activity cellular_component
YNL270C YNL270C ALP1 hom Verified 6.13398308491728 4.28528176605483e-10 yes 5 6.42129908334768e-11 1 NA FT PLASMA MEMBRANE Arginine transporter; expression is normally very low and it is unclear what conditions would induce significant expression; ALP1 has a paralog, CAN1, that arose from the whole genome duplication basic amino acid transport basic amino acid transmembrane transporter activity integral to membrane|plasma membrane
YAL067W-A_p YAL067W-A YAL067W-A hom Uncharacterized 6.12966086828254 4.4033294789759e-10 yes 6 2.89780768550365e-10 3 NA Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YFR048W YFR048W RMD8 hom Verified 5.32860041695177 4.94862360342241e-08 yes 7 7.56778100799609e-08 8 NA FT CELL CYCLE Cytosolic protein required for sporulation biological_process molecular_function cytoplasm
YER158C_p YER158C YER158C hom Uncharacterized 5.2105651556999 9.41331236127685e-08 yes 8 3.39689374569318e-10 1 NA Protein of unknown function; potentially phosphorylated by Cdc28p; YER158C has a paralog, AFR1, that arose from the whole genome duplication biological_process molecular_function cellular_component
YLR283W_p YLR283W YLR283W hom Uncharacterized 4.96217735357891 3.48536499348035e-07 yes 9 7.26927514274648e-08 2 NA FT MITOCHONDRION Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR283W is not an essential gene biological_process molecular_function mitochondrion
YLL020C_d YLL020C YLL020C hom Dubious 4.78419394279936 8.58374313351463e-07 yes 10 1.94960565838062e-07 5 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KNS1 Unknown Unknown Unknown
YAL020C YAL020C ATS1 hom Verified 4.57198154548473 2.41566749080195e-06 yes 11 4.74879217784362e-06 10 NA FT RNA PROCESSING|CELL DIVISION|CYTOSKELETON ORGANIZATION Protein required, with Elongator complex, Kti11p, and Kti12p, for modification of wobble nucleosides in tRNA; has a potential role in regulatory interactions between microtubules and the cell cycle microtubule-based process|budding cell bud growth|microtubule cytoskeleton organization|tRNA wobble uridine modification molecular_function cytoplasm
YOR375C YOR375C GDH1 hom Verified 4.55510688329437 2.61794742685534e-06 yes 12 2.71477083992683e-06 5 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS NUCLEUS NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources; GDH1 has a paralog, GDH3, that arose from the whole genome duplication glutamate biosynthetic process|ammonia assimilation cycle glutamate dehydrogenase (NADP+) activity nucleus|cytoplasm
YLR131C YLR131C ACE2 hom Verified 4.55262041199477 2.64909089725403e-06 yes 13 0.000131458397884315 87 NA FF|FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CELL DIVISION NUCLEUS Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication Unknown|regulation of transcription involved in G1 phase of mitotic cell cycle RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding cytosol|nucleus
YPL224C YPL224C MMT2 hom Verified 4.47954277720574 3.74015492354318e-06 yes 14 2.22912858990105e-06 5 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt1p cellular iron ion homeostasis molecular_function mitochondrion|integral to membrane
YHR129C YHR129C ARP1 hom Verified 4.46335238206905 4.03435966065737e-06 yes 15 5.34517625516125e-07 14 NA FT CELL CYCLE|CYTOSKELETON ORGANIZATION CYTOSKELETON Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; putative ortholog of mammalian centractin nuclear migration|establishment of mitotic spindle orientation structural constituent of cytoskeleton cell cortex|dynactin complex|spindle pole body|astral microtubule
YIL008W YIL008W URM1 hom Verified 4.44819167100476 4.32981204446294e-06 yes 16 8.28999514724772e-06 10 NA FT RNA PROCESSING|CELL DIVISION|RESPONSE TO OXIDATIVE STRESS NUCLEUS Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs; receives sulfur from the E1-like enzyme Uba4p and transfers it to tRNA; also functions as a protein tag with roles in nutrient sensing and oxidative stress response cellular response to oxidative stress|tRNA wobble position uridine thiolation|cell budding|protein urmylation|invasive growth in response to glucose limitation|tRNA wobble uridine modification protein tag cytosol|nucleus|cytoplasm
YJL176C YJL176C SWI3 hom Verified 4.41036832156551 5.15974714014707e-06 yes 17 5.28480000559239e-05 9 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS NUCLEUS RSC COMPLEX Subunit of the SWI/SNF chromatin remodeling complex; SWI/SNF regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; relocates to the cytosol under hypoxic conditions cellular alcohol catabolic process|ATP-dependent chromatin remodeling|positive regulation of mating type switching|sucrose catabolic process|carbon catabolite activation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter histone binding|DNA binding SWI/SNF complex|nucleus
YKL065C YKL065C YET1 hom Verified 4.37195041453739 6.15707481818823e-06 yes 18 7.23643950255505e-07 3 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Endoplasmic reticulum transmembrane protein; may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein biological_process molecular_function ribosome|integral to membrane|endoplasmic reticulum|endoplasmic reticulum membrane
YCR025C_d YCR025C YCR025C hom Dubious 4.35542494605276 6.64045088497822e-06 yes 19 7.705297933823e-06 16 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR025C is not an essential gene Unknown Unknown Unknown
YGR225W YGR225W AMA1 hom Verified 4.06492887885213 2.40235555559604e-05 yes 20 1.38965413693563e-05 6 NA FT CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION NUCLEUS UBIQUITIN LIGASE COMPLEX Activator of meiotic anaphase promoting complex (APC/C); Cdc20p family member; required for initiation of spore wall assembly; required for Clb1p degradation during meiosis ascospore wall assembly|positive regulation of protein catabolic process|ascospore formation|meiosis I enzyme activator activity anaphase-promoting complex
YER075C YER075C PTP3 hom Verified 4.04745505943568 2.58887595183867e-05 yes 21 4.51160008560661e-06 5 NA FT PROTEIN LOCALIZATION|SIGNALING|PROTEIN PHOSPHORYLATION NUCLEUS Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the cytoplasm inactivation of MAPK activity involved in osmosensory signaling pathway|regulation of sporulation|regulation of protein localization|protein dephosphorylation|inactivation of MAPK activity involved in conjugation with cellular fusion protein tyrosine phosphatase activity nucleus|cytoplasm
YGR122W YGR122W YGR122W hom Verified 3.99394262068714 3.24917979831048e-05 yes 22 0.000330654350560554 100 NA FF|FT TRANSCRIPTION FROM RNA POL II Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress negative regulation of transcription from RNA polymerase II promoter|nuclear-transcribed mRNA catabolic process, non-stop decay molecular_function cytoplasm
YPL144W YPL144W POC4 hom Verified 3.92756996627149 4.29042312581384e-05 yes 23 3.36419582721531e-05 22 NA FT PROTEIN COMPLEX ORG/BIOGENESIS Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions proteasome assembly|chaperone-mediated protein complex assembly molecular_function intracellular|cytoplasm
YHR007C-A_p YHR007C-A YHR007C-A hom Uncharacterized 3.84777895407845 5.95967614888652e-05 yes 24 7.54866273636073e-06 7 NA Putative protein of unknown function; identified by expression profiling and mass spectrometry biological_process molecular_function cellular_component
YLR453C YLR453C RIF2 hom Verified 3.84592899030383 6.00482713928286e-05 yes 25 3.06521446679715e-05 29 NA FT NUCLEUS|CHROMOSOME Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation telomere capping|telomere maintenance via telomerase telomeric DNA binding nuclear telomere cap complex
YHR185C YHR185C PFS1 hom Verified 3.83703209942227 6.22650999695844e-05 yes 26 0.000102636285154533 10 NA FT CELL WALL ORG/BIOGENESIS NUCLEUS|CYTOSKELETON Sporulation protein required for prospore membrane formation at selected spindle poles, ensures functionality of all four spindle pole bodies during meiosis II; not required for meiotic recombination or meiotic chromosome segregation ascospore wall assembly molecular_function cellular_component
YDR316W YDR316W OMS1 hom Verified 3.81708897583623 6.75177415129338e-05 yes 27 0.000269451548296369 20 NA FT MITOCHONDRION Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif; multicopy suppressor of respiratory defects caused by OXA1 mutations biological_process S-adenosylmethionine-dependent methyltransferase activity mitochondrial envelope|mitochondrion
YGR212W YGR212W SLI1 hom Verified 3.81225122635985 6.88534015761856e-05 yes 28 8.69148155340772e-05 10 NA FT ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin response to drug N-acetyltransferase activity nuclear envelope|plasma membrane
YOL125W YOL125W TRM13 hom Verified 3.7794594417868 7.85845951029306e-05 yes 29 3.97744516946032e-06 4 NA FT RNA PROCESSING NUCLEUS 2'-O-methyltransferase responsible for modification of tRNA at position 4; C-terminal domain has similarity to Rossmann-fold (RFM) superfamily of RNA methyltransferases tRNA methylation tRNA methyltransferase activity nucleus|cytoplasm
YML029W YML029W USA1 hom Verified 3.75300053256578 8.73652418504276e-05 yes 30 4.05999793397074e-05 8 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|PROTEOLYSIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM UBIQUITIN LIGASE COMPLEX Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p ER-associated protein catabolic process|mRNA splicing, via spliceosome|positive regulation of protein oligomerization protein complex scaffold Hrd1p ubiquitin ligase ERAD-L complex|endoplasmic reticulum membrane
YPL148C YPL148C PPT2 hom Verified 3.7522405236432 8.7630596390824e-05 yes 31 0.00148620730735854 55 NA FF|FT KETONE METABOLISM|LIPID METABOLISM MITOCHONDRION Phosphopantetheine:protein transferase (PPTase), activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation protein-cofactor linkage holo-[acyl-carrier-protein] synthase activity mitochondrion
YGR248W YGR248W SOL4 hom Verified 3.74796350961801 8.91380912560766e-05 yes 32 5.2978520447026e-05 12 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS NUCLEUS 6-phosphogluconolactonase; protein abundance increases in response to DNA replication stress; SOL4 has a paralog, SOL3, that arose from the whole genome duplication pentose-phosphate shunt, oxidative branch 6-phosphogluconolactonase activity cytosol|nucleus|cytoplasm
YCR028C YCR028C FEN2 hom Verified 3.71897170023372 0.000100017729615501 yes 33 0.000493646551363141 13 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION PLASMA MEMBRANE Plasma membrane H+-pantothenate symporter; confers sensitivity to the antifungal agent fenpropimorph; relocalizes from vacuole to cytoplasm upon DNA replication stress pantothenate transmembrane transport|endocytosis pantothenate transmembrane transporter activity integral to membrane|plasma membrane
YPL202C YPL202C AFT2 hom Verified 3.7091745129011 0.000103968038330035 yes 34 6.56721770282805e-05 28 NA FT TRANSCRIPTION FROM RNA POL II|ION HOMEOSTASIS|ION HOMEOSTASIS|RESPONSE TO NUTRIENT LEVELS|RESPONSE TO OXIDATIVE STRESS NUCLEUS|MITOCHONDRION Iron-regulated transcriptional activator; activates genes involved in intracellular iron use and required for iron homeostasis and resistance to oxidative stress; AFT2 has a paralog, AFT1, that arose from the whole genome duplication cellular response to oxidative stress|cellular iron ion homeostasis|positive regulation of transcription from RNA polymerase II promoter in response to iron ion starvation|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription mitochondrion|nucleus
YNL304W YNL304W YPT11 hom Verified 3.70367624956756 0.000106248711208919 yes 35 0.000126252757401541 4 NA FT SIGNALING|MITOCHONDRION ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH Rab family GTPase that interacts with the C-terminal tail domain of Myo2p; mediates distribution of mitochondria and endoplasmic reticuli to daughter cells mitochondrion inheritance|endoplasmic reticulum inheritance|Golgi inheritance|Golgi localization GTPase activity incipient cellular bud site|endoplasmic reticulum|cellular bud neck|cellular bud tip
YGL006W-A_p YGL006W-A YGL006W-A hom Uncharacterized 3.68839897452688 0.000112834797472561 yes 36 8.46275531009948e-06 7 NA Putative protein of unknown function; identified by SAGE biological_process molecular_function cellular_component
YDR007W YDR007W TRP1 hom Verified 3.64622352996242 0.00013306125293227 yes 37 0.0271761122142776 380 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA) tryptophan biosynthetic process phosphoribosylanthranilate isomerase activity cytoplasm
YDR295C YDR295C HDA2 hom Verified 3.64459116595416 0.000133908595701342 yes 38 4.66940674474784e-05 10 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex containing an Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance negative regulation of transcription from RNA polymerase II promoter|gene silencing by RNA|histone deacetylation|gene silencing involved in chronological cell aging histone deacetylase activity|chromatin binding|DNA binding nucleus|HDA1 complex
YKL157W YKL157W APE2 hom Verified 3.58138587044317 0.000170888217046191 yes 39 0.000234247655879702 17 NA FT PROTEOLYSIS MITOCHONDRION Aminopeptidase yscII; may have a role in obtaining leucine from dipeptide substrates; APE2 has a paralog, AAP1, that arose from the whole genome duplication peptide catabolic process metalloaminopeptidase activity mitochondrion|extracellular region|cell wall-bounded periplasmic space
YDL136W YDL136W RPL35B hom Verified 3.58131385532618 0.000170935335248307 yes 40 0.000448550657625117 39 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal 60S subunit protein L35B; homologous to mammalian ribosomal protein L35 and bacterial L29; RPL35B has a paralog, RPL35A, that arose from the whole genome duplication cytoplasmic translation|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic large ribosomal subunit|preribosome, large subunit precursor
YNR051C YNR051C BRE5 hom Verified 3.55827141001395 0.000186651735502007 yes 41 0.000214932712629234 56 NA FT VESICLE-MEDIATED TRANSPORT Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A protein deubiquitination|ribophagy|regulation of ER to Golgi vesicle-mediated transport|Unknown molecular_function cytoplasm
YGR192C YGR192C TDH3 hom Verified 3.53931929606275 0.000200580157512795 yes 42 0.000262197966897404 22 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Glyceraldehyde-3-phosphate dehydrogenase, isozyme 3; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; TDH3 has a paralog, TDH2, that arose from the whole genome duplication gluconeogenesis|reactive oxygen species metabolic process|glycolysis|apoptotic process glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity mitochondrion|fungal-type cell wall|lipid particle|plasma membrane|cytoplasm
YHR207C YHR207C SET5 hom Verified 3.38922092224483 0.000350457576797243 yes 43 0.000484159101334446 51 NA FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Methyltransferase involved in methylation of histone H4 Lys5, -8, -12; S-adenosylmethionine-dependent; zinc-finger protein, contains one canonical and two unusual fingers in unusual arrangements; deletion enhances replication of positive-strand RNA virus histone lysine methylation S-adenosylmethionine-dependent methyltransferase activity nuclear chromatin|nucleus|cytoplasm
YNL058C_p YNL058C YNL058C hom Uncharacterized 3.35809599331767 0.000392406766564534 yes 44 0.000220392998131268 23 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL058C is not an essential gene biological_process molecular_function fungal-type vacuole
YAL013W YAL013W DEP1 hom Verified 3.33588479708994 0.000425141954782161 yes 45 0.000402037973884734 34 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Transcriptional modulator involved in regulation of structural phospholipid biosynthesis genes and metabolically unrelated genes, as well as maintenance of telomeres, mating efficiency, and sporulation positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of chromatin silencing at rDNA|regulation of transcription from RNA polymerase II promoter|histone deacetylation|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of chromatin silencing at telomere|negative regulation of transcription from RNA polymerase II promoter|regulation of DNA-dependent DNA replication initiation|Unknown molecular_function Rpd3L-Expanded complex|Rpd3L complex
YLR065C YLR065C ENV10 hom Verified 3.33056805346922 0.000433344877071065 yes 46 0.00286883656587074 101 NA FF|FT VACUOLAR PROTEIN PROCESSING Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing; YLR065C is not an essential gene vacuolar protein processing molecular_function integral to membrane
YAL004W_d YAL004W YAL004W hom Dubious 3.32394942248705 0.000443761452418188 yes 47 0.00111013954364323 26 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene SSA1/YAL005C Unknown Unknown Unknown
YBR269C_p YBR269C FMP21 hom Uncharacterized 3.32057589726796 0.000449159650296098 yes 48 0.000505310588271236 19 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YIL166C_p YIL166C YIL166C hom Uncharacterized 3.31857473491116 0.000452390536506654 yes 49 0.00051519711314897 16 NA Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; YIL166C is a non-essential gene transport transporter activity integral to membrane|membrane
YBL093C YBL093C ROX3 hom Verified 3.30928783918893 0.00046766812077959 yes 50 0.001178403326619 55 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme negative regulation of transcription from RNA polymerase II promoter|transcriptional open complex formation at RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription factor recruiting transcription factor activity core mediator complex|nucleus
YEL006W YEL006W YEA6 hom Verified 3.30129485932951 0.000481198417233151 yes 51 0.000545777983077594 21 NA FT MITOCHONDRION Putative mitochondrial NAD+ transporter, member of the mitochondrial carrier subfamily (see also YIA6); has putative human ortholog transport|NAD transmembrane transport transporter activity|NAD transporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YMR319C YMR319C FET4 hom Verified 3.26591156436713 0.000545561597624667 yes 52 0.00655923552687607 131 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Low-affinity Fe(II) transporter of the plasma membrane intracellular copper ion transport|zinc ion transport|low-affinity iron ion transport|copper ion import copper ion transmembrane transporter activity|iron ion transmembrane transporter activity integral to membrane|plasma membrane|integral to plasma membrane
YHR037W YHR037W PUT2 hom Verified 3.26412928192891 0.000549005253474636 yes 53 0.00111953419158781 42 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION Delta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism glutamate biosynthetic process|proline catabolic process to glutamate 1-pyrroline-5-carboxylate dehydrogenase activity mitochondrion|mitochondrial matrix
YGR231C YGR231C PHB2 hom Verified 3.2051095160949 0.000675055499500593 yes 54 0.00146436091410578 19 NA FT PROTEOLYSIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation mitochondrion inheritance|protein folding|negative regulation of proteolysis|replicative cell aging molecular_function mitochondrion|mitochondrial inner membrane
YKR019C YKR019C IRS4 hom Verified 3.19341405448525 0.000703005920559967 yes 55 0.0738238254060098 418 NA FF|FT LIPID METABOLISM|SIGNALING|CELL WALL ORG/BIOGENESIS|RESPONSE TO NUTRIENT LEVELS|GENE SILENCING MITOCHONDRION EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication autophagy|fungal-type cell wall organization|chromatin silencing at rDNA|inositol lipid-mediated signaling|CVT pathway|cellular response to starvation molecular_function mitochondrion|pre-autophagosomal structure
YDR175C YDR175C RSM24 hom Verified 3.17132020809896 0.00075873885333097 yes 56 0.00136428127764607 36 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YDL188C YDL188C PPH22 hom Verified 3.16601076397715 0.000772725373601565 yes 57 0.000767612584683378 19 NA FT CELL CYCLE|TRANSLATION|CELL DIVISION|CYTOSKELETON ORGANIZATION NUCLEUS|CHROMOSOME Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; PPH22 has a paralog, PPH21, that arose from the whole genome duplication actin filament organization|budding cell bud growth|G1/S transition of mitotic cell cycle|protein dephosphorylation|mitotic cell cycle spindle assembly checkpoint|regulation of translation protein serine/threonine phosphatase activity condensed nuclear chromosome, centromeric region
YBL068W YBL068W PRS4 hom Verified 3.16359485671118 0.000779167801167093 yes 58 0.000124073172964687 17 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication fungal-type cell wall organization|5-phosphoribose 1-diphosphate biosynthetic process ribose phosphate diphosphokinase activity cytoplasm
YOR070C YOR070C GYP1 hom Verified 3.16002214348645 0.000788785743520361 yes 59 0.0161279319688282 239 NA FF|FT VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM MITOCHONDRION|GOLGI APPARATUS Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion vesicle-mediated transport Rab GTPase activator activity mitochondrion|Golgi apparatus
YBL069W YBL069W AST1 hom Verified 3.13948248456039 0.000846232660065618 yes 60 0.000899001095728774 47 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS GOLGI APPARATUS|PLASMA MEMBRANE Lipid raft associated protein; interacts with the plasma membrane ATPase Pma1p and has a role in its targeting to the plasma membrane by influencing its incorporation into lipid rafts; sometimes classified in the medium-chain dehydrogenase/reductases (MDRs) superfamily; AST1 has a paralog, AST2, that arose from the whole genome duplication protein targeting to membrane|protein transport into membrane raft molecular_function late endosome|membrane raft|Golgi apparatus|plasma membrane
YOR030W YOR030W DFG16 hom Verified 3.11340190678197 0.000924719887256638 yes 61 0.00326693098045265 118 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS Probable multiple transmembrane protein; involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; is glycosylated and phosphorylated; interacts with Rim21p and Rim9p in the plasma membrane to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; required for accumulation of processed Rim101p pseudohyphal growth|protein processing molecular_function integral to membrane
YNR033W YNR033W ABZ1 hom Verified 3.10773621104603 0.000942631300379493 yes 62 0.000254472801923268 18 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress para-aminobenzoic acid biosynthetic process 4-amino-4-deoxychorismate synthase activity cytoplasm
YDR245W YDR245W MNN10 hom Verified 3.10529166220102 0.000950457406352805 yes 63 0.00159078937721925 56 NA FT CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Subunit of a Golgi mannosyltransferase complex also containing Anp1p, Mnn9p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltransferase family N-glycan processing|cell wall mannoprotein biosynthetic process|substituted mannan metabolic process|barrier septum assembly alpha-1,6-mannosyltransferase activity alpha-1,6-mannosyltransferase complex
YLR021W YLR021W IRC25 hom Verified 3.09564290247009 0.000981933579548339 yes 64 0.00140623440574066 43 NA FT PROTEIN COMPLEX ORG/BIOGENESIS Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions proteasome assembly|chaperone-mediated protein complex assembly|nuclear-transcribed mRNA catabolic process, non-stop decay molecular_function intracellular
YMR209C_p YMR209C YMR209C hom Uncharacterized 3.07698540844948 0.00104552768284 no 65 0.00102672574191478 45 NA Putative S-adenosylmethionine-dependent methyltransferase; YMR209C is not an essential gene biological_process S-adenosylmethionine-dependent methyltransferase activity cellular_component
YOL044W YOL044W PEX15 hom Verified 3.04165091629586 0.00117642292762271 no 66 0.000518519258751632 31 NA FT PROTEIN LOCALIZATION|SIGNALING|PEROXISOME ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Phosphorylated tail-anchored type II integral peroxisomal membrane protein required for peroxisome biogenesis, cells lacking Pex15p mislocalize peroxisomal matrix proteins to cytosol, overexpression results in impaired peroxisome assembly protein import into peroxisome matrix, receptor recycling protein anchor integral to peroxisomal membrane
YDR034W-B_p YDR034W-B YDR034W-B hom Uncharacterized 3.03881005299508 0.00118757278607434 no 67 0.0012470642169816 33 NA Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery biological_process molecular_function cellular_component
YPL177C YPL177C CUP9 hom Verified 3.03121095697671 0.00121787501935258 no 68 0.00148050798828362 48 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Homeodomain-containing transcriptional repressor; regulates expression of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription; CUP9 has a paralog, TOS8, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter|negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter RNA polymerase II repressing transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity nucleus
YMR171C YMR171C EAR1 hom Verified 3.00718801186383 0.00131838314083408 no 69 0.00100355365102216 30 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT Specificity factor required for Rsp5p-dependent ubiquitination and sorting of specific cargo proteins at the multivesicular body; mRNA is targeted to the bud via the mRNA transport system involving She2p protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway molecular_function endosome
YLR385C YLR385C SWC7 hom Verified 2.97700788409089 0.00145538262371096 no 70 0.00125534489908646 16 NA FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin chromatin remodeling molecular_function Swr1 complex|nucleus
YJL218W_p YJL218W YJL218W hom Uncharacterized 2.9768481271114 0.00145614118254438 no 71 0.00146214627244649 28 NA Putative acetyltransferase; similar to bacterial galactoside O-acetyltransferases; induced by oleate in an OAF1/PIP2-dependent manner; promoter contains an oleate response element consensus sequence; non-essential gene biological_process acetyltransferase activity cellular_component
YDR375C YDR375C BCS1 hom Verified 2.97480743343874 0.00146586260942 no 72 0.00242251505417423 41 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases protein insertion into mitochondrial membrane from inner side|chaperone-mediated protein complex assembly|mitochondrial respiratory chain complex III assembly protein transmembrane transporter activity|ATPase activity mitochondrion|mitochondrial inner membrane
YKL129C YKL129C MYO3 hom Verified 2.97066619047181 0.00148577289070489 no 73 0.000200541503524254 15 NA FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION CYTOSKELETON One of two type I myosins; localizes to actin cortical patches; deletion of MYO3 has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization bipolar cellular bud site selection|fungal-type cell wall organization|endocytosis|exocytosis|actin cortical patch localization|response to osmotic stress microfilament motor activity actin cortical patch
YIL114C YIL114C POR2 hom Verified 2.96895752119307 0.00149405950382408 no 74 0.00141815887505951 20 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Putative mitochondrial porin (voltage-dependent anion channel); not required for mitochondrial membrane permeability or mitochondrial osmotic stability; POR2 has a paralog, POR1, that arose from the whole genome duplication DNA transport|ion transport|cell redox homeostasis voltage-gated anion channel activity mitochondrial outer membrane|mitochondrion|integral to membrane
YDR020C_p YDR020C DAS2 hom Uncharacterized 2.92686730665925 0.00171197465388032 no 75 0.000814696518088341 37 NA FT NUCLEOTIDE METABOLISM NUCLEUS Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases biological_process molecular_function nucleus|cytoplasm
YBR008C YBR008C FLR1 hom Verified 2.91857653541099 0.00175816771670838 no 76 0.000987639439594424 60 NA FT PLASMA MEMBRANE Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; expression induced in cells treated with the mycotoxin patulin; relocalizes from nucleus to plasma membrane upon DNA replication stress drug transmembrane transport|transmembrane transport fluconazole transporter activity|drug transmembrane transporter activity integral to membrane|plasma membrane
YPL048W YPL048W CAM1 hom Verified 2.91689983423778 0.00176764642303905 no 77 0.00186432464629123 42 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION NUCLEUS Nuclear protein required for transcription of MXR1; binds the MXR1 promoter in the presence of other nuclear factors; binds calcium and phospholipids; has similarity to translational cofactor EF-1 gamma ribosome biogenesis|positive regulation of transcription from RNA polymerase II promoter phospholipid binding|transcription coactivator activity|calcium ion binding nucleus
YDL199C_p YDL199C YDL199C hom Uncharacterized 2.89443661876022 0.00189919792239429 no 78 0.000763076432871376 20 NA Putative transporter, member of the sugar porter family transport|transmembrane transport substrate-specific transmembrane transporter activity integral to membrane|membrane
YIR016W_p YIR016W YIR016W hom Uncharacterized 2.88977509104179 0.0019275876821016 no 79 0.000592388042513238 28 NA Putative protein of unknown function; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; overexpression causes a cell cycle delay or arrest; non-essential gene; YIR016W has a paralog, YOL036W, that arose from the whole genome duplication biological_process molecular_function cellular_component
YER137C_p YER137C YER137C hom Uncharacterized 2.88936123427869 0.00193012670511597 no 80 0.00223937548626857 53 NA Putative protein of unknown function biological_process molecular_function cellular_component
YGL148W YGL148W ARO2 hom Verified 2.87489014243465 0.0020208404828757 no 81 0.0186757060750389 208 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM Bifunctional chorismate synthase and flavin reductase; catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids; protein abundance increases in response to DNA replication stress aromatic amino acid family biosynthetic process chorismate synthase activity|riboflavin reductase (NADPH) activity cytoplasm
YOR066W YOR066W MSA1 hom Verified 2.84928178063431 0.00219090266403919 no 82 0.00162107237675834 50 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE NUCLEUS Activator of G1-specific transcription factors, MBF and SBF; involved in regulation of the timing of G1-specific gene transcription and cell cycle initiation; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation G1/S transition of mitotic cell cycle|regulation of transcription involved in G1 phase of mitotic cell cycle|regulation of cell size molecular_function nucleus|cytoplasm
YNR068C_p YNR068C YNR068C hom Uncharacterized 2.84464240668479 0.00222306531814172 no 83 0.00181875318370501 51 NA Putative protein of unknown function; exhibits homology to C-terminal end of Bul1p; expressed as a readthrough product of BSC5, the readthrough locus being termed BUL3; the BUL3 readthrough product is involved in ubiquitin-mediated sorting of plasma membrane proteins and interacts with WW domains of Rsp5p in vitro, but in a functionally different way than the non-readthrough form biological_process molecular_function cellular_component
YNL047C YNL047C SLM2 hom Verified 2.84056631758668 0.00225167541927164 no 84 0.000910530272374827 26 NA FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|SIGNALING|CYTOSKELETON ORGANIZATION PLASMA MEMBRANE Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; SLM2 has a paralog, SLM1, that arose from the whole genome duplication eisosome assembly|TOR signaling cascade|regulation of cell growth|actin filament bundle assembly|endosomal transport|establishment or maintenance of actin cytoskeleton polarity|actin cytoskeleton organization phosphatidylinositol binding plasma membrane
YLR286C YLR286C CTS1 hom Verified 2.82100118852754 0.00239370127531127 no 85 0.00253617499453981 56 NA FT CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH Endochitinase, required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p cytokinesis, completion of separation|chitin catabolic process endochitinase activity nuclear envelope|extracellular region|fungal-type cell wall|endoplasmic reticulum|cellular bud neck
YHR073W YHR073W OSH3 hom Verified 2.8189172602154 0.00240929685801801 no 86 0.00264765773261004 80 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOPLASMIC RETICULUM Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability karyogamy involved in conjugation with cellular fusion|endocytosis|exocytosis|positive regulation of phosphatase activity|maintenance of cell polarity|pseudohyphal growth|sterol transport|invasive growth in response to glucose limitation lipid binding|oxysterol binding|1-phosphatidylinositol binding|sterol transporter activity cortical endoplasmic reticulum|cytoplasm
YHR125W_d YHR125W YHR125W hom Dubious 2.81532541609417 0.00243639323181806 no 87 0.00390160427797467 81 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YEL057C_p YEL057C YEL057C hom Uncharacterized 2.80946200031828 0.00248121884905309 no 88 0.000806383451425078 27 NA Protein of unknown function involved in telomere maintenance; target of UME6 regulation biological_process molecular_function cellular_component
YOL152W YOL152W FRE7 hom Verified 2.78811800881057 0.00265076140688889 no 89 0.0027804668225264 43 NA FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY PLASMA MEMBRANE Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels iron ion transport|copper ion import ferric-chelate reductase activity integral to membrane|plasma membrane
YGR007W YGR007W ECT1 hom Verified 2.7850901808944 0.00267564188893118 no 90 0.0033384898631983 65 NA FT LIPID METABOLISM NUCLEUS Ethanolamine-phosphate cytidylyltransferase, catalyzes the second step of phosphatidylethanolamine biosynthesis; involved in the maintenance of plasma membrane; similar to mammalian CTP: phosphocholine cytidylyl-transferases phosphatidylethanolamine biosynthetic process ethanolamine-phosphate cytidylyltransferase activity nucleus|cytoplasm
YGL200C YGL200C EMP24 hom Verified 2.77131293271139 0.00279153710622049 no 91 0.00283430445488311 68 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles protein retention in ER lumen|vesicle organization|ER to Golgi vesicle-mediated transport molecular_function integral to membrane|endoplasmic reticulum|ER to Golgi transport vesicle
YKR093W YKR093W PTR2 hom Verified 2.76814760570126 0.00281879581395096 no 92 0.00794752747155563 156 NA FF|FT PROTEIN LOCALIZATION PLASMA MEMBRANE Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p dipeptide transport|tripeptide transport|peptide transport dipeptide transporter activity|tripeptide transporter activity|peptide transporter activity integral to membrane|plasma membrane
YMR207C YMR207C HFA1 hom Verified 2.76079830468348 0.00288301368539488 no 93 0.00216554304121378 45 NA FT KETONE METABOLISM|LIPID METABOLISM MITOCHONDRION Mitochondrial acetyl-coenzyme A carboxylase; catalyzes the production of malonyl-CoA in mitochondrial fatty acid biosynthesis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress fatty acid biosynthetic process acetyl-CoA carboxylase activity mitochondrion
YJL144W YJL144W YJL144W hom Verified 2.73902490075709 0.00308108530318066 no 94 0.0020102403243575 34 NA Cytoplasmic hydrophilin essential in dessication-rehydration process; expression induced by osmotic stress, starvation and during stationary phase; protein abundance increases in response to DNA replication stress cellular response to water deprivation molecular_function cytoplasm
YIL013C YIL013C PDR11 hom Verified 2.73802222828845 0.00309049490149204 no 95 0.00338799352930752 69 NA FT NUCLEOTIDE METABOLISM ATP-binding cassette (ABC) transporter, multidrug transporter involved in multiple drug resistance; mediates sterol uptake when sterol biosynthesis is compromised; regulated by Pdr1p; required for anaerobic growth sterol transport ATPase activity, coupled to transmembrane movement of substances integral to membrane|membrane
YOR032C YOR032C HMS1 hom Verified 2.73228085498441 0.00314487493757481 no 96 0.00487147240612252 46 NA FT NUCLEUS Basic helix-loop-helix (bHLH) protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant pseudohyphal growth sequence-specific DNA binding transcription factor activity cellular_component
YHR176W YHR176W FMO1 hom Verified 2.72245592847399 0.00323993378509444 no 97 0.0029585873302726 79 NA FT OXIDATION-REDUCTION PROCESS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins protein folding N,N-dimethylaniline monooxygenase activity endoplasmic reticulum membrane
YNL248C YNL248C RPA49 hom Verified 2.71071944314155 0.00335687032906132 no 98 0.00395115480023449 66 NA FT NUCLEUS RNA polymerase I subunit A49 transcription elongation from RNA polymerase I promoter|transcription of nuclear large rRNA transcript from RNA polymerase I promoter|regulation of cell size molecular_function DNA-directed RNA polymerase I complex
YNL318C YNL318C HXT14 hom Verified 2.69146972905825 0.00355689769259781 no 99 0.00217173790733956 36 NA FT MITOCHONDRION|PLASMA MEMBRANE Protein with similarity to hexose transporter family members, expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies hexose transport galactose transmembrane transporter activity mitochondrion|integral to membrane|plasma membrane
YBR044C YBR044C TCM62 hom Verified 2.6770791014764 0.00371335494936207 no 100 0.000525627978975821 35 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; putative chaperone mitochondrial respiratory chain complex II assembly unfolded protein binding mitochondrion|mitochondrial inner membrane
YPR008W YPR008W HAA1 hom Verified 2.67184148302775 0.00377181372124076 no 101 0.00272099827550558 44 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Transcriptional activator involved in adaptation to weak acid stress; activates transcription of TPO2, YRO2, and other genes encoding membrane stress proteins; HAA1 has a paralog, CUP2, that arose from the whole genome duplication; relocalizes from cytoplasm to nucleus upon DNA replication stress response to acid|positive regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding RNA polymerase II transcription factor activity nucleus
YLR149C YLR149C YLR149C hom Verified 2.67038298656145 0.00378823869705035 no 102 0.0061203232630047 91 NA Protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene; protein abundance increases in response to DNA replication stress biological_process molecular_function cellular_component
YER113C YER113C TMN3 hom Verified 2.65785107422533 0.00393203176637735 no 103 0.00261166125536461 53 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn2p; member of Transmembrane Nine family with 9 transmembrane segments; localizes to Golgi; induced by 8-methoxypsoralen plus UVA irradiation cellular copper ion homeostasis|vacuolar transport|pseudohyphal growth|invasive growth in response to glucose limitation molecular_function COPI-coated vesicle|integral to membrane|Golgi apparatus
YGR142W YGR142W BTN2 hom Verified 2.65346820212335 0.00398346382948376 no 104 0.00356949598494795 67 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|ION HOMEOSTASIS|ION HOMEOSTASIS v-SNARE binding protein; facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase; BTN2 has a paralog, CUR1, that arose from the whole genome duplication intracellular protein transport|amino acid transport|retrograde transport, endosome to Golgi|regulation of pH SNARE binding cytosol|late endosome|perinuclear region of cytoplasm
YLR312C_p YLR312C YLR312C hom Uncharacterized 2.65240853867255 0.00399598883876738 no 105 0.00470713491550394 53 NA Putative protein of unknown function biological_process molecular_function cellular_component
YIL024C_p YIL024C YIL024C hom Uncharacterized 2.65071690681643 0.00401605668184211 no 106 0.00253045038553888 51 NA Putative protein of unknown function; non-essential gene; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p biological_process molecular_function cellular_component
YAL047C YAL047C SPC72 hom Verified 2.64985529386781 0.00402631264800177 no 107 0.00468429743925148 75 NA FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION NUCLEUS|CYTOSKELETON Component of the cytoplasmic Tub4p (gamma-tubulin) complex, binds spindle pole bodies and links them to microtubules; has roles in astral microtubule formation and stabilization microtubule nucleation|nuclear migration along microtubule|mitotic cell cycle spindle orientation checkpoint|mitotic spindle elongation|mitotic sister chromatid segregation structural constituent of cytoskeleton outer plaque of spindle pole body
YIL041W YIL041W GVP36 hom Verified 2.63780122277583 0.00417227395001724 no 108 0.00695091813365067 54 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION ENDOMEMBRANE SYSTEM|GOLGI APPARATUS BAR domain-containing protein that localizes to both early and late Golgi vesicles; required for adaptation to varying nutrient concentrations, fluid-phase endocytosis, polarization of the actin cytoskeleton, and vacuole biogenesis vacuole organization|endocytosis|establishment or maintenance of actin cytoskeleton polarity molecular_function integral to Golgi membrane|cytoplasm
YHR139C-A_d YHR139C-A YHR139C-A hom Dubious 2.63058301883658 0.0042619274046749 no 109 0.00295284041782902 66 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGR143W YGR143W SKN1 hom Verified 2.62041958039431 0.00439108203704912 no 110 0.00857958449843965 69 NA FT LIPID METABOLISM|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM Protein involved in sphingolipid biosynthesis; type II membrane protein with similarity to Kre6p fungal-type cell wall organization|(1->6)-beta-D-glucan biosynthetic process|sphingolipid biosynthetic process glucosidase activity integral to membrane
YLR055C YLR055C SPT8 hom Verified 2.61902308040481 0.00440909904857955 no 111 0.00513667224988366 99 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS HISTONE ACETYLTRANSFERASE Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters histone acetylation|negative regulation of transcription from RNA polymerase II promoter|chromatin modification|positive regulation of transcription from RNA polymerase II promoter TBP-class protein binding|transcription cofactor activity nucleus|SAGA complex
YBR280C YBR280C SAF1 hom Verified 2.61607706306056 0.00444732401518761 no 112 0.00415037182911036 47 NA FT PROTEOLYSIS UBIQUITIN LIGASE COMPLEX F-Box protein involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence; interacts with Skp1 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity SCF ubiquitin ligase complex
YHR194W YHR194W MDM31 hom Verified 2.60228155100198 0.00463028954948584 no 113 0.00662532965128042 85 NA FT ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS NUCLEUS|MITOCHONDRION Mitochondrial protein that may have a role in phospholipid metabolism; inner membrane protein with similarity to Mdm32p; required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MMM2, MDM10, MDM12, and MDM34 mitochondrion inheritance|cellular ion homeostasis|mitochondrion organization|Unknown molecular_function mitochondrial inner membrane|nucleus
YGL235W_p YGL235W YGL235W hom Uncharacterized 2.60136290757338 0.00464270845886488 no 114 0.00264533080261973 27 NA Putative protein of unknown function; potential Cdc28p substrate; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2 biological_process molecular_function cellular_component
YHR192W YHR192W LNP1 hom Verified 2.59637446044405 0.00471066634273275 no 115 0.0115379921165815 81 NA Lunapark family member involved in ER network formation; localizes to ER junctions and this localization is regulated by the yeast atlastin ortholog Sey1p; interacts with the reticulon protein Rtn1p; induced in response to the DNA-damaging agent MMS endoplasmic reticulum tubular network organization molecular_function endoplasmic reticulum tubular network|cytoplasm
YMR205C YMR205C PFK2 hom Verified 2.59293906614267 0.00475798143941644 no 116 0.012279630391647 152 NA FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes proton transport|glycolysis mRNA binding|6-phosphofructokinase activity mitochondrion|6-phosphofructokinase complex|cytoplasm
YIL094C YIL094C LYS12 hom Verified 2.5886929011116 0.0048170485069741 no 117 0.00457676301338595 79 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate lysine biosynthetic process homoisocitrate dehydrogenase activity mitochondrion
YPL055C YPL055C LGE1 hom Verified 2.58463139706992 0.00487415760729321 no 118 0.00883330223435062 133 NA FT CHROMATIN ORGANIZATION NUCLEUS Protein of unknown function; null mutant forms abnormally large cells, and homozygous diploid null mutant displays delayed premeiotic DNA synthesis and reduced efficiency of meiotic nuclear division histone methylation|protein monoubiquitination|regulation of cell size|histone ubiquitination|premeiotic DNA replication molecular_function nucleus
YDR169C-A_p YDR169C-A YDR169C-A hom Uncharacterized 2.5803066041011 0.00493563148704734 no 119 0.00648343797634378 73 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YOR038C YOR038C HIR2 hom Verified 2.57747185131263 0.0049762993652267 no 120 0.00376669474281069 58 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p DNA replication-independent nucleosome assembly|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter nucleosome binding|transcription corepressor activity|DNA binding HIR complex|nucleus
YBR232C_d YBR232C YBR232C hom Dubious 2.57534986942091 0.00500693677639486 no 121 0.00415538228492155 83 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YJL136W-A_p YJL136W-A YJL136W-A hom Uncharacterized 2.57402929344174 0.00502608810177567 no 122 0.00156649518970132 21 NA Putative protein of unknown function; identified by SAGE biological_process molecular_function cellular_component
YGR070W YGR070W ROM1 hom Verified 2.57368484277932 0.00503109412712217 no 123 0.00659980459271822 87 NA FT SIGNALING|NUCLEOTIDE METABOLISM GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP small GTPase mediated signal transduction|activation of Rho GTPase activity Rho guanyl-nucleotide exchange factor activity intracellular
YBR111W-A YBR111W-A SUS1 hom Verified 2.57201039085655 0.00505549285205402 no 124 0.0108738823085079 117 NA FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE|HISTONE ACETYLTRANSFERASE Component of both the SAGA histone acetylase and TREX-2 complexes; interacts with RNA polymerase II; involved in mRNA export coupled transcription activation and elongation; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP poly(A)+ mRNA export from nucleus|regulation of protein localization|nuclear retention of pre-mRNA at the site of transcription|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|histone deubiquitination|histone H3-K4 methylation|transcription elongation from RNA polymerase II promoter|histone H3-K79 methylation|positive regulation of transcription from RNA polymerase II promoter enzyme activator activity DUBm complex|nucleoplasm|transcription export complex 2|SAGA complex|nuclear pore
YKR007W YKR007W MEH1 hom Verified 2.55148901293653 0.00536318530300151 no 125 0.00790953231419043 140 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; loss results in a defect in vacuolar acidification microautophagy|vacuolar acidification molecular_function fungal-type vacuole membrane|EGO complex|late endosome membrane
YJL099W YJL099W CHS6 hom Verified 2.55104727571923 0.00536998781607634 no 126 0.00918224504293454 118 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM GOLGI APPARATUS Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication Golgi to plasma membrane transport|fungal-type cell wall chitin biosynthetic process molecular_function trans-Golgi network transport vesicle|clathrin-coated vesicle|exomer complex
YKL197C YKL197C PEX1 hom Verified 2.53800791741829 0.00557427311270844 no 127 0.00479840440496158 62 NA FT PROTEIN LOCALIZATION|SIGNALING|PEROXISOME ORGANIZATION AAA-peroxin that heterodimerizes with AAA-peroxin Pex6p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; induced by oleic acid and upregulated during anaerobiosis protein import into peroxisome matrix, receptor recycling ATPase activity|protein heterodimerization activity peroxisomal membrane|peroxisome
YLR084C YLR084C RAX2 hom Verified 2.53264896733533 0.00566021283623153 no 128 0.00877775020894058 47 NA FT CELL CYCLE|CELL DIVISION MITOCHONDRION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p; RAX2 mRNA stability is regulated by Mpt5p cellular bud site selection molecular_function mitochondrion|cellular bud scar|cellular bud neck|membrane
YLR261C_d YLR261C VPS63 hom Dubious 2.52763313355346 0.00574171382935702 no 129 0.0458195751415018 234 NA FF Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect Unknown Unknown Unknown
YHR080C YHR080C YHR080C hom Verified 2.52746073807197 0.00574453345990653 no 130 0.00682692003483617 88 NA FT MITOCHONDRION Protein of unknown function; may interact with ribosomes, based on co-purification experiments; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YHR080C has a paralog, YSP2, that arose from the whole genome duplication biological_process molecular_function mitochondrion|ribosome
YOL111C YOL111C MDY2 hom Verified 2.50271664430945 0.00616220856280507 no 131 0.0124510726932947 121 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION NUCLEUS Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Get4p; required for efficient mating; involved in shmoo formation and nuclear migration in the pre-zygote; associates with ribosomes protein insertion into ER membrane|cell morphogenesis involved in conjugation with cellular fusion|posttranslational protein targeting to membrane molecular_function ribosome|TRC complex|nucleus|cytoplasm
YNL242W YNL242W ATG2 hom Verified 2.49320769900272 0.00632973848041361 no 132 0.00485147491404246 58 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION Peripheral membrane protein required for autophagic vesicle formation; also required for vesicle formation during pexophagy and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria; forms cytoplasmic foci upon DNA replication stress mitochondrion degradation|piecemeal microautophagy of nucleus|peroxisome degradation|CVT pathway|autophagic vacuole assembly molecular_function pre-autophagosomal structure|cytoplasm|extrinsic to membrane
YOL105C YOL105C WSC3 hom Verified 2.49245265270021 0.00634321217887551 no 133 0.00394600411448694 70 NA FT SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|PEROXISOME ORGANIZATION SITE OF POLARIZED GROWTH Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity; involved in the response to heat shock and other stressors; regulates 1,3-beta-glucan synthesis response to heat|peroxisome degradation|Rho protein signal transduction transmembrane signaling receptor activity mating projection tip
YDL167C YDL167C NRP1 hom Verified 2.48772989401926 0.00642806662577421 no 134 0.00857013431295245 99 NA Putative RNA binding protein of unknown function; localizes to stress granules induced by glucose deprivation; predicted to be involved in ribosome biogenesis biological_process molecular_function cytoplasmic stress granule|cytoplasm
YPR164W YPR164W MMS1 hom Verified 2.4871456491044 0.0064386333355989 no 135 0.00659184593733121 111 NA FT RESPONSE TO DNA DAMAGE NUCLEUS UBIQUITIN LIGASE COMPLEX Subunit of an E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of the replication fork such as the fork-pausing complex and leading strand polymerase, preventing fork collapse and promoting efficient recovery during replication stress; regulates Ty1 transposition; involved with Rtt101p in nonfunctional rRNA decay replication fork processing|negative regulation of transposition, RNA-mediated|recombinational repair|nonfunctional rRNA decay molecular_function Cul8-RING ubiquitin ligase complex
YLR443W YLR443W ECM7 hom Verified 2.47885995874082 0.00659015218464539 no 136 0.00658613036349718 78 NA FT ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency fungal-type cell wall organization|calcium ion transport molecular_function integral to membrane
YAR035W YAR035W YAT1 hom Verified 2.46657804064874 0.00682054998260776 no 137 0.00443645666654669 55 NA FT KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated carnitine metabolic process|alcohol metabolic process carnitine O-acetyltransferase activity mitochondrion
YML054C YML054C CYB2 hom Verified 2.46225922113537 0.00690324201043127 no 138 0.00432991601789907 46 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions lactate metabolic process L-lactate dehydrogenase (cytochrome) activity mitochondrion|mitochondrial intermembrane space
YOR107W YOR107W RGS2 hom Verified 2.46179253245952 0.00691223044040713 no 139 0.00944995735546822 98 NA FT SIGNALING NUCLEUS|PLASMA MEMBRANE Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p adenylate cyclase-modulating G-protein coupled receptor signaling pathway GTPase activator activity nucleus|cytoplasm
YEL036C YEL036C ANP1 hom Verified 2.45841249130837 0.00697763911250451 no 140 0.0167880385499696 156 NA FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol protein N-linked glycosylation alpha-1,6-mannosyltransferase activity|mannosyltransferase activity alpha-1,6-mannosyltransferase complex|Golgi cis cisterna
YMR269W YMR269W TMA23 hom Verified 2.44233653997963 0.00729626812237605 no 141 0.00729184722515555 102 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS NUCLEUS Nucleolar protein implicated in ribosome biogenesis; deletion extends chronological lifespan ribosomal small subunit biogenesis molecular_function ribosome|nucleolus
YMR085W_p YMR085W YMR085W hom Uncharacterized 2.43775937128461 0.00738930395122187 no 142 0.00805858457950634 79 NA FT CARBOHYDRATE METABOLISM Putative protein of unknown function; YMR085W and adjacent ORF YMR084W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1 biological_process molecular_function cellular_component
YJL117W YJL117W PHO86 hom Verified 2.42871989257034 0.00757611682746772 no 143 0.0112394815992395 84 NA FT VESICLE-MEDIATED TRANSPORT|ION HOMEOSTASIS|ION HOMEOSTASIS ENDOPLASMIC RETICULUM Endoplasmic reticulum (ER) resident protein; required for ER exit of the high-affinity phosphate transporter Pho84p, specifically required for packaging of Pho84p into COPII vesicles; protein abundance increases in response to DNA replication stress protein folding|ER to Golgi vesicle-mediated transport|regulation of phosphate transport unfolded protein binding endoplasmic reticulum
YFL049W YFL049W SWP82 hom Verified 2.41874008381012 0.00778718208729565 no 144 0.00521461493056127 77 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS RSC COMPLEX Member of the SWI/SNF chromatin remodeling complex; has an as yet unidentified role in the complex; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p; relocates to the cytosol under hypoxic conditions positive regulation of transcription from RNA polymerase II promoter molecular_function SWI/SNF complex|nucleus
YCR009C YCR009C RVS161 hom Verified 2.41703442525236 0.00782376858409638 no 145 0.0115635699482534 134 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION|RESPONSE TO NUTRIENT LEVELS SITE OF POLARIZED GROWTH|CYTOSKELETON Amphiphysin-like lipid raft protein; interacts with Rvs167p and regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress conjugation with cellular fusion|actin cytoskeleton reorganization|endocytosis|actin cortical patch localization|response to starvation|response to osmotic stress|lipid tube assembly|actin cytoskeleton organization cytoskeletal protein binding|lipid binding membrane raft|mating projection tip|mating projection|actin cortical patch
YJL064W_d YJL064W YJL064W hom Dubious 2.41008159728485 0.00797447652635889 no 146 0.00681903643625354 74 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL065C/DLS1 Unknown Unknown Unknown
YOR118W YOR118W RTC5 hom Verified 2.40940159195022 0.007989352314379 no 147 0.0145768334003058 84 NA Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity biological_process molecular_function cytoplasm
YLR093C YLR093C NYV1 hom Verified 2.40841390835866 0.00801100232148438 no 148 0.00603933874978451 60 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION v-SNARE component of the vacuolar SNARE complex involved in vesicle fusion; inhibits ATP-dependent Ca(2+) transport activity of Pmc1p in the vacuolar membrane vesicle-mediated transport|vacuole fusion, non-autophagic|vesicle fusion SNAP receptor activity SNARE complex|fungal-type vacuole membrane
YDR204W YDR204W COQ4 hom Verified 2.39883157583595 0.00822373895130578 no 149 0.0056941785125206 101 NA FT KETONE METABOLISM|COFACTOR METABOLISM MITOCHONDRION Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex ubiquinone biosynthetic process molecular_function mitochondrial inner membrane
YLR319C YLR319C BUD6 hom Verified 2.39686813260356 0.00826793676085763 no 150 0.0109064359312211 54 NA FT CELL CYCLE|CHROMATIN ORGANIZATION|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Actin- and formin-interacting protein; stimulates actin cable nucleation by recruiting actin monomers to Bni1p; involved in polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate bipolar cellular bud site selection|positive regulation of formin-nucleated actin cable assembly|cellular bud site selection|Rho protein signal transduction|extrachromosomal circular DNA localization involved in cell aging|establishment of cell polarity|response to osmotic stress|cytokinesis cytoskeletal regulatory protein binding polarisome|actin cap|spindle pole body|mating projection tip
YIR039C YIR039C YPS6 hom Verified 2.39660624711291 0.00827384763808466 no 151 0.0118769016892674 109 NA FT CELL WALL ORG/BIOGENESIS|PROTEOLYSIS PLASMA MEMBRANE Putative GPI-anchored aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance fungal-type cell wall organization aspartic-type endopeptidase activity fungal-type cell wall
YMR035W YMR035W IMP2 hom Verified 2.39264238844462 0.00836376805256039 no 152 0.00362536325220279 74 NA FT PROTEIN LOCALIZATION|PROTEOLYSIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p protein processing involved in protein targeting to mitochondrion endopeptidase activity mitochondrial inner membrane peptidase complex
YOL027C YOL027C MDM38 hom Verified 2.37428909517714 0.00879138892789301 no 153 0.0127281975349657 99 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|TRANSLATION|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS MITOCHONDRION Mitochondrial protein, forms a complex with Mba1p to facilitate recruitment of mRNA-specific translational activators to ribosomes; roles in protein export and K+/H+ exchange; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome potassium ion transport|mitochondrial respiratory chain complex III biogenesis|cellular potassium ion homeostasis|proton transport|positive regulation of mitochondrial translation|mitochondrial respiratory chain complex IV biogenesis|protein insertion into mitochondrial membrane ribosome binding mitochondrion|mitochondrial inner membrane
YAL051W YAL051W OAF1 hom Verified 2.37287220908162 0.00882518471491978 no 154 0.00595899975229309 81 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GENE SILENCING NUCLEUS Oleate-activated transcription factor; acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis; OAF1 has a paralog, PIP2, that arose from the whole genome duplication cellular response to oleic acid|positive regulation of fatty acid beta-oxidation|positive regulation of chromatin silencing at telomere|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YKL115C_d YKL115C YKL115C hom Dubious 2.36864618001809 0.00892666183968149 no 155 0.00752685011404827 96 NA Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1 Unknown Unknown Unknown
YKR013W YKR013W PRY2 hom Verified 2.36337701000612 0.0090546182278239 no 156 0.0178006461484145 135 NA Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY1; may be involved in detoxification of hydrophobic compounds; PRY2 has a paralog, PRY1, that arose from the whole genome duplication biological_process molecular_function extracellular region|fungal-type vacuole
YGR285C YGR285C ZUO1 hom Verified 2.36012237034426 0.00913445382886616 no 157 0.0102476545631407 145 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION NUCLEUS|MITOCHONDRION RIBOSOME Ribosome-associated chaperone, functions in ribosome biogenesis and, in partnership with Ssz1p and SSb1/2, as a chaperone for nascent polypeptide chains; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p protein folding|ribosomal subunit export from nucleus|rRNA processing|regulation of translational fidelity unfolded protein binding mitochondrion|ribosome|nucleolus|polysome|cytoplasm
YMR124W_p YMR124W YMR124W hom Uncharacterized 2.35749952673734 0.0091992393788149 no 158 0.00584681930186001 100 NA Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization biological_process molecular_function cytoplasm
YBR165W YBR165W UBS1 hom Verified 2.35396414971826 0.00928720119515847 no 159 0.00323448464520526 32 NA FT PROTEIN LOCALIZATION NUCLEUS Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity protein export from nucleus|protein ubiquitination molecular_function nucleus
YNL335W_p YNL335W DDI3 hom Uncharacterized 2.34645826307905 0.00947639437429166 no 160 0.00965034416819669 87 NA Protein of unknown function; expression is induced over 100-fold by DNA damage; induction decreased in rad6 and rad18 mutants biological_process molecular_function cellular_component
YJL053W YJL053W PEP8 hom Verified 2.33751897325592 0.0097061077829869 no 161 0.0130653315252056 157 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress protein retention in Golgi apparatus|retrograde transport, endosome to Golgi protein transporter activity endosome|retromer complex, inner shell|retromer complex
YLR148W YLR148W PEP3 hom Verified 2.33389710187862 0.00980055527216876 no 162 0.0413484059956318 252 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT Component of CORVET tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis regulation of SNARE complex assembly|regulation of vacuole fusion, non-autophagic|vacuole fusion, non-autophagic|late endosome to vacuole transport|vesicle docking involved in exocytosis|Golgi to endosome transport phosphatidylinositol binding|protein binding, bridging fungal-type vacuole membrane|HOPS complex|proteasome storage granule|CORVET complex|extrinsic to vacuolar membrane
YGL147C YGL147C RPL9A hom Verified 2.32867206270682 0.00993822261056061 no 163 0.0103318146160847 114 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L9A; nearly identical to paralog Rpl9Bp; homologous to mammalian ribosomal protein L9 and bacterial L6 cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YER034W YER034W YER034W hom Verified 2.32486018641757 0.0100397187386796 no 164 0.0128601182940128 86 NA FT NUCLEUS Protein of unknown function; non-essential gene; expression induced upon calcium shortage; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus|cytoplasm
YKL081W YKL081W TEF4 hom Verified 2.32111090588773 0.0101404294698479 no 165 0.0126166221965312 97 NA FT TRANSLATION MITOCHONDRION RIBOSOME Gamma subunit of translational elongation factor eEF1B, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex translational elongation translation elongation factor activity mitochondrion|ribosome|eukaryotic translation elongation factor 1 complex
YPR130C_d YPR130C YPR130C hom Dubious 2.32076773807094 0.0101496912975892 no 166 0.011493708172376 116 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR209C_d YDR209C YDR209C hom Dubious 2.31504409304385 0.0103052595632499 no 167 0.00721004950851253 66 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YDR210W. Unknown Unknown Unknown
YER118C YER118C SHO1 hom Verified 2.28813610004673 0.0110647982620526 no 168 0.0102258097068262 61 NA FT SIGNALING SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Transmembrane osmosensor involved in activation of the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway; phosphorylated by Hog1p; interacts with Pbs2p, Msb2p, Hkr1p, and Ste11p signal transduction involved in filamentous growth|establishment of cell polarity|osmosensory signaling pathway|cellular response to heat|cytokinesis osmosensor activity|MAP-kinase scaffold activity integral to membrane|plasma membrane|plasma membrane part|cellular bud|cellular bud neck|mating projection tip
YAR029W_p YAR029W YAR029W hom Uncharacterized 2.28330303700072 0.0112062621282739 no 169 0.00872319698567841 101 NA Member of DUP240 gene family but contains no transmembrane domains; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern biological_process molecular_function cytoplasm
YCR011C YCR011C ADP1 hom Verified 2.2778497101018 0.011367766710653 no 170 0.00758735113886368 75 NA FT NUCLEOTIDE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Putative ATP-dependent permease of the ABC transporter family of proteins transport|transmembrane transport ATPase activity, coupled to transmembrane movement of substances integral to membrane|endoplasmic reticulum|cytoplasm
YCR027C YCR027C RHB1 hom Verified 2.27356645083545 0.0114960332627708 no 171 0.0124164234789602 99 NA FT VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM PLASMA MEMBRANE Putative Rheb-related GTPase involved in regulating canavanine resistance and arginine uptake; member of the Ras superfamily of G-proteins lysine transport|retrograde transport, endosome to Golgi|arginine transport GTPase activity extrinsic to plasma membrane
YKR018C YKR018C YKR018C hom Verified 2.25823034596595 0.0119656511359632 no 172 0.010030108400118 89 NA FT NUCLEUS|MITOCHONDRION Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress; YKR018C has a paralog, IML2, that arose from the whole genome duplication biological_process molecular_function nucleus|cytoplasm
YGL229C YGL229C SAP4 hom Verified 2.24517229477206 0.0123785369757442 no 173 0.0125346646225177 83 NA FT CELL CYCLE MITOCHONDRION Protein required for function of the Sit4p protein phosphatase, member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p G1/S transition of mitotic cell cycle protein serine/threonine phosphatase activity mitochondrion|cytoplasm
YDR125C YDR125C ECM18 hom Verified 2.23482924476836 0.0127142805599898 no 174 0.0249926534613624 132 NA FT CELL WALL ORG/BIOGENESIS MITOCHONDRION Protein of unknown function; ECM18 has a paralog, ICT1, that arose from the whole genome duplication fungal-type cell wall organization molecular_function mitochondrion
YHL044W_p YHL044W YHL044W hom Uncharacterized 2.23418423499306 0.0127354766519441 no 175 0.00809392185124235 113 NA FT PLASMA MEMBRANE Putative integral membrane protein, member of DUP240 gene family; green fluorescent protein (GFP)-fusion protein localizes to the plasma membrane in a punctate pattern biological_process molecular_function plasma membrane
YML116W-A_d YML116W-A YML116W-A hom Dubious 2.2304703626653 0.0128581164437341 no 176 0.00392335213755998 52 NA Putative protein of unknown function Unknown Unknown Unknown
YNL276C_d YNL276C YNL276C hom Dubious 2.2254716778766 0.0130247951883127 no 177 0.011074429820707 104 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene MET2/YNL277W Unknown Unknown Unknown
YDR382W YDR382W RPP2B hom Verified 2.22533635444127 0.0130293333303372 no 178 0.00898019222285935 72 NA FT TRANSLATION RIBOSOME Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm translational elongation|cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YKR073C_d YKR073C YKR073C hom Dubious 2.22497642962675 0.0130414102499941 no 179 0.0201927220811503 208 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YHL031C YHL031C GOS1 hom Verified 2.22090727081583 0.0131786213379546 no 180 0.0417944357973463 241 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|GOLGI APPARATUS v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28 Golgi vesicle transport|vesicle fusion SNAP receptor activity SNARE complex|integral to membrane|Golgi medial cisterna
YMR011W YMR011W HXT2 hom Verified 2.19957904953519 0.0139183874762201 no 181 0.0133505951150331 123 NA FT PLASMA MEMBRANE High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose glucose transport pentose transmembrane transporter activity|mannose transmembrane transporter activity|fructose transmembrane transporter activity|glucose transmembrane transporter activity integral to membrane|plasma membrane
YCR044C YCR044C PER1 hom Verified 2.19274472529245 0.0141628881993308 no 182 0.0658377775787258 277 NA FF|FT LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein of the endoplasmic reticulum, required for GPI-phospholipase A2 activity that remodels the GPI anchor as a prerequisite for association of GPI-anchored proteins with lipid rafts; functionally complemented by human ortholog PERLD1 GPI anchor biosynthetic process|cellular manganese ion homeostasis molecular_function fungal-type vacuole membrane|integral to membrane|endoplasmic reticulum
YKL114C YKL114C APN1 hom Verified 2.18533785357426 0.0144320419311543 no 183 0.0303171537052774 263 NA FF|FT RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine base-excision repair 3'-tyrosyl-DNA phosphodiesterase activity|DNA-(apurinic or apyrimidinic site) lyase activity|double-stranded DNA specific 3'-5' exodeoxyribonuclease activity|phosphoric diester hydrolase activity mitochondrion|nucleus
YIL120W YIL120W QDR1 hom Verified 2.17714146585388 0.0147350070178109 no 184 0.0120844535094636 71 NA FT PLASMA MEMBRANE Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for resistance to quinidine, ketoconazole, fluconazole, and barban; QDR1 has a paralog, AQR1, that arose from the whole genome duplication drug transmembrane transport drug transmembrane transporter activity integral to membrane|plasma membrane
YDR001C YDR001C NTH1 hom Verified 2.17664095495343 0.0147536834648335 no 185 0.0115054677326175 91 NA FT CARBOHYDRATE METABOLISM Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p; NTH1 has a paralog, NTH2, that arose from the whole genome duplication trehalose catabolic process|response to stress alpha,alpha-trehalase activity cytosol|cytoplasm
YML021C YML021C UNG1 hom Verified 2.17294125897256 0.0148923693202459 no 186 0.013628886818431 125 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION Uracil-DNA glycosylase, required for repair of uracil in DNA formed by spontaneous cytosine deamination, not required for strand-specific mismatch repair, cell-cycle regulated, expressed in late G1, localizes to mitochondria and nucleus DNA repair uracil DNA N-glycosylase activity mitochondrion|nucleus
YCR017C YCR017C CWH43 hom Verified 2.17187971554913 0.0149323684287621 no 187 0.0259492250867625 176 NA FT LIPID METABOLISM|CELL WALL ORG/BIOGENESIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Putative sensor/transporter protein involved in cell wall biogenesis; contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites; null mutation is synthetically lethal with pkc1 deletion fungal-type cell wall organization|GPI anchor biosynthetic process molecular_function integral to membrane|integral to plasma membrane|cellular bud neck|cellular bud tip
YPR126C_d YPR126C YPR126C hom Dubious 2.16361896047357 0.0152468025756157 no 188 0.015900344570503 106 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR159W YDR159W SAC3 hom Verified 2.14935729350649 0.0158030440282545 no 189 0.041928446441118 279 NA FF|FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE Nuclear pore-associated protein; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; similar to the human germinal center-associated nuclear protein (GANP) ribosomal small subunit biogenesis|actin filament-based process|mRNA export from nucleus|mRNA 3'-end processing|mitosis|protein export from nucleus|transcription-coupled nucleotide-excision repair|nuclear retention of pre-mRNA at the site of transcription|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery protein binding transcription export complex 2|nuclear pore
YGL066W YGL066W SGF73 hom Verified 2.14713473448403 0.0158912783714922 no 190 0.0269587280082251 153 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|RNA LOCALIZATION NUCLEUS HISTONE ACETYLTRANSFERASE SAGA complex subunit; has a role in anchoring the deubiquitination module into SAGA and SLIK complexes; involved in preinitiation complex assembly at promoters; human ortholog ataxin-7 is associated with spinocerebellar ataxia diseases; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay histone deubiquitination|mRNA export from nucleus|histone acetylation|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|protein complex assembly|chromatin modification histone acetyltransferase activity|enzyme activator activity|structural molecule activity DUBm complex|SLIK (SAGA-like) complex|SAGA complex
YMR036C YMR036C MIH1 hom Verified 2.14560191394245 0.0159523763106606 no 191 0.00684982037836652 60 NA FT CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION NUCLEUS Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25 G2/M transition of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity protein tyrosine phosphatase activity nucleus|cytoplasm
YJR015W_p YJR015W YJR015W hom Uncharacterized 2.13746719364517 0.0162800056375987 no 192 0.0115032713457801 71 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Putative protein of unknown function; localizes to the endoplasmic reticulum and cytoplasm; predicted to encode a membrane transporter based on phylogenetic analysis; YJR015W is a non-essential gene biological_process molecular_function integral to membrane|endoplasmic reticulum|cytoplasm
YHR013C YHR013C ARD1 hom Verified 2.13672837232967 0.0163100454679766 no 193 0.015781541915573 161 NA FT CHROMATIN ORGANIZATION RIBOSOME Subunit of protein N-terminal acetyltransferase NatA; NatA is comprised of Nat1p, Ard1p, and Nat5p; acetylates many proteins and thus affects telomeric silencing, cell cycle, heat-shock resistance, mating, and sporulation; human Ard1p levels are elevated in cancer cells; protein abundance increases in response to DNA replication stress histone acetylation|N-terminal protein amino acid acetylation peptide alpha-N-acetyltransferase activity cytosolic ribosome|NatA complex
YLR218C YLR218C COA4 hom Verified 2.13407699973815 0.0164182391461764 no 194 0.0144779752666858 109 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION NUCLEUS|MITOCHONDRION Twin Cx(9)C protein involved in cytochrome c oxidase assembly or stability; localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; interacts genetically with CYC1 and with cytochrome c oxidase assembly factors mitochondrial respiratory chain complex IV assembly|mitochondrial respiratory chain complex assembly molecular_function nucleus|mitochondrial intermembrane space|cytoplasm
YNL154C YNL154C YCK2 hom Verified 2.13334682717738 0.016448142755065 no 195 0.0187966799634216 118 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL DIVISION|PROTEIN PHOSPHORYLATION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; YCK2 has a paralog, YCK1, that arose from the whole genome duplication endocytosis|cell morphogenesis|protein phosphorylation|cytokinesis|response to glucose stimulus protein serine/threonine kinase activity|protein kinase activity plasma membrane|cellular bud neck|mating projection
YGL045W YGL045W RIM8 hom Verified 2.13144039920056 0.0165264388198887 no 196 0.0348317129058321 287 NA FF|FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family meiosis|protein processing|invasive growth in response to glucose limitation|ubiquitin-dependent endocytosis molecular_function internal side of plasma membrane
YLR418C YLR418C CDC73 hom Verified 2.13109875001248 0.0165405038408037 no 197 0.0594480869286903 347 NA FF|FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION NUCLEUS|CHROMOSOME RNA POL II, HOLOENZYME Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; protein abundance increases in response to DNA replication stress transcription elongation from RNA polymerase I promoter|negative regulation of DNA recombination|mRNA 3'-end processing|recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex|positive regulation of transcription elongation from RNA polymerase II promoter|Unknown|regulation of transcription-coupled nucleotide-excision repair|transcription elongation from RNA polymerase II promoter chromatin binding|TFIIF-class binding transcription factor activity|RNA polymerase II core binding|RNA polymerase II transcription factor binding transcription factor activity nucleus|transcriptionally active chromatin|Cdc73/Paf1 complex
YPL164C YPL164C MLH3 hom Verified 2.12980379100654 0.0165939077913789 no 198 0.0158839263775397 111 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Protein involved in DNA mismatch repair and crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian microsatellite instability mismatch repair|reciprocal meiotic recombination molecular_function nucleus|MutLbeta complex
YOR271C_p YOR271C FSF1 hom Uncharacterized 2.12685199694462 0.0167161911981677 no 199 0.0143421786798616 100 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis biological_process molecular_function mitochondrion|integral to membrane
YHR204W YHR204W MNL1 hom Verified 2.12593537142086 0.0167543205951068 no 200 0.0143004781407589 153 NA FT PROTEOLYSIS ENDOPLASMIC RETICULUM Alpha-1,2-specific exomannosidase of the endoplasmic reticulum; in complex with Pdi1p, generates a Man7GlcNac2 oligosaccharide signal on glycoproteins destined for ubiquitin-proteasome degradation ER-associated protein catabolic process carbohydrate binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity endoplasmic reticulum lumen
YPL191C_p YPL191C YPL191C hom Uncharacterized 2.12589510409829 0.0167559973225676 no 201 0.0144246531213266 119 NA Putative protein of unknown function; diploid deletion strain exhibits high budding index; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm biological_process molecular_function cytoplasm
YDL021W YDL021W GPM2 hom Verified 2.1211668419277 0.0169538822816999 no 202 0.0186559380231252 139 NA FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event biological_process phosphoglycerate mutase activity|molecular_function cytosol|cytoplasm
YLR032W YLR032W RAD5 hom Verified 2.11216440157942 0.0173361753508623 no 203 0.0209006541950286 178 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME DNA helicase; proposed to promote replication fork regression during postreplication repair by template switching; RING finger containing ubiquitin ligase; stimulates the synthesis of free and PCNA-bound polyubiquitin chains by Ubc13p-Mms2p; required for error-prone translesion synthesis; forms nuclear foci upon DNA replication stress double-strand break repair|postreplication repair|protein polyubiquitination|free ubiquitin chain polymerization four-way junction helicase activity|four-way junction DNA binding|DNA-dependent ATPase activity|Y-form DNA binding nuclear chromatin
YPR173C YPR173C VPS4 hom Verified 2.11031355153859 0.0174156785487839 no 204 0.0340874469136836 222 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|LIPID METABOLISM|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT ENDOPLASMIC RETICULUM AAA-ATPase involved in multivesicular body (MVB) protein sorting, ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism late endosome to vacuole transport via multivesicular body sorting pathway|protein retention in Golgi apparatus|intralumenal vesicle formation|protein homooligomerization|sterol metabolic process|late endosome to vacuole transport ATPase activity|protein homodimerization activity|ATP binding endosome|endoplasmic reticulum|membrane|cytoplasm
YHL043W YHL043W ECM34 hom Verified 2.10495214395083 0.0176477370054211 no 205 0.0125758101625554 91 NA FT CELL WALL ORG/BIOGENESIS Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins fungal-type cell wall organization molecular_function cellular_component
YDR515W YDR515W SLF1 hom Verified 2.09895214017008 0.0179105599441472 no 206 0.0189488665575399 137 NA FT TRANSLATION|ION HOMEOSTASIS|ION HOMEOSTASIS RNA binding protein that associates with polysomes; may be involved in regulating mRNA translation; involved in the copper-dependent mineralization of copper sulfide complexes on cell surface in cells cultured in copper salts; SLF1 has a paralog, SRO9, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress cellular copper ion homeostasis|regulation of translation RNA binding polysome|cytoplasm
YHR121W YHR121W LSM12 hom Verified 2.09389314723358 0.0181347499325162 no 207 0.0161645818632688 136 NA FT NUCLEUS Protein of unknown function that may function in RNA processing; interacts with Pbp1p and Pbp4p and associates with ribosomes; contains an RNA-binding LSM domain and an AD domain; GFP-fusion protein is induced by the DNA-damaging agent MMS; relative distribution to the nucleus increases upon DNA replication stress RNA metabolic process RNA binding ribosome|nucleus|cytoplasmic stress granule|cytoplasm
YIL085C YIL085C KTR7 hom Verified 2.08971556416322 0.0183216790203838 no 208 0.0157140148667788 133 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM GOLGI APPARATUS Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR7 has a paralog, KTR5, that arose from the whole genome duplication fungal-type cell wall organization|protein N-linked glycosylation mannosyltransferase activity Golgi apparatus
YGL144C YGL144C ROG1 hom Verified 2.08920607125329 0.0183445885779778 no 209 0.0217114611012855 109 NA FT LIPID METABOLISM Protein with putative serine active lipase domain; ROG1 has a paralog, YDL109C, that arose from the whole genome duplication cellular lipid metabolic process lipase activity cellular_component
YGL056C YGL056C SDS23 hom Verified 2.08255566764231 0.0186458718623746 no 210 0.0200696745841416 141 NA FT CELL DIVISION NUCLEUS One of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; involved in cell separation during budding; SDS23 has a paralog, SDS24, that arose from the whole genome duplication cytokinetic cell separation molecular_function nucleus|cytoplasm
YPL135W YPL135W ISU1 hom Verified 2.07789119500178 0.0188596908451106 no 211 0.0211676892504837 149 NA FT RNA PROCESSING|ION HOMEOSTASIS|ION HOMEOSTASIS|COFACTOR METABOLISM MITOCHONDRION Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable cellular iron ion homeostasis|iron-sulfur cluster assembly|tRNA wobble uridine modification ferrous iron binding mitochondrion|mitochondrial matrix
YLR039C YLR039C RIC1 hom Verified 2.07640184381388 0.0189284004364448 no 212 0.0794812174196848 283 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes intracellular protein transport|retrograde transport, endosome to Golgi guanyl-nucleotide exchange factor activity nucleus|Ric1p-Rgp1p complex|Golgi membrane|guanyl-nucleotide exchange factor complex
YIL018W YIL018W RPL2B hom Verified 2.0625343115761 0.0195784471871515 no 213 0.0164744448864916 120 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L2B; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2B has a paralog, RPL2A, that arose from the whole genome duplication; expression is upregulated at low temperatures cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YBR020W YBR020W GAL1 hom Verified 2.05978590315699 0.0197095064044513 no 214 0.0178426808768453 146 NA FT CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; GAL1 has a paralog, GAL3, that arose from the whole genome duplication galactose catabolic process via UDP-galactose|carbohydrate phosphorylation|positive regulation of transcription by galactose galactokinase activity cytoplasm
YHR028C YHR028C DAP2 hom Verified 2.05931473964352 0.0197320486905991 no 215 0.0298871299675365 135 NA FT PROTEOLYSIS Dipeptidyl aminopeptidase, synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p protein processing dipeptidyl-peptidase activity fungal-type vacuole membrane
YDR304C YDR304C CPR5 hom Verified 2.05890233854859 0.0197517975138832 no 216 0.0158071646931678 123 NA FT ENDOPLASMIC RETICULUM Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum, catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfolded proteins in the ER biological_process peptidyl-prolyl cis-trans isomerase activity endoplasmic reticulum|cytoplasm
YGL246C YGL246C RAI1 hom Verified 2.05086967760573 0.0201398198885767 no 217 0.0226120407312309 131 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z deadenylation-dependent decapping of nuclear-transcribed mRNA|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|termination of RNA polymerase II transcription, poly(A)-coupled|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) enzyme regulator activity|m7G(5')pppN diphosphatase activity nucleus
YOR351C YOR351C MEK1 hom Verified 2.04863327760106 0.0202489940354719 no 218 0.0139551588394432 140 NA FT CELL CYCLE|PROTEIN PHOSPHORYLATION NUCLEUS Meiosis-specific serine/threonine protein kinase, functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids meiosis|meiotic recombination checkpoint|protein phosphorylation protein serine/threonine kinase activity|protein kinase activity nucleus
YLR338W_d YLR338W OPI9 hom Dubious 2.04617675886974 0.0203694915458297 no 219 0.0549467933281452 323 NA FF Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF VRP1/YLR337C Unknown Unknown Unknown
YGR084C YGR084C MRP13 hom Verified 2.03997605445454 0.0206763553854613 no 220 0.0130673544457126 107 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YHR146W YHR146W CRP1 hom Verified 2.03364845141723 0.020993526499128 no 221 0.0279849824796662 174 NA FT NUCLEUS Protein that binds to cruciform DNA structures biological_process DNA binding nucleus
YNR002C YNR002C ATO2 hom Verified 2.03323241376979 0.0210145238703036 no 222 0.0125476034176533 104 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION|PLASMA MEMBRANE Putative transmembrane protein involved in export of ammonia; ammonia is a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Y. lipolytica Gpr1p; ATO2 has a paralog, ADY2, that arose from the whole genome duplication ammonium transport|nitrogen utilization ammonium transmembrane transporter activity mitochondrion|integral to membrane|plasma membrane
YOR059C YOR059C YOR059C hom Verified 2.03191251200244 0.0210812568233634 no 223 0.0129115120505559 104 NA FT LIPID METABOLISM Lipid particle protein of unknown function; contains a putative lipase serine active site; induced by transcription factor Rpn4p; protein abundance increases in response to DNA replication stress biological_process molecular_function lipid particle
YOL018C YOL018C TLG2 hom Verified 2.03002384371643 0.0211770578413047 no 224 0.115312562680097 436 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT GOLGI APPARATUS Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16) inositolphosphoceramide metabolic process|Golgi to vacuole transport|endocytosis|mannosyl-inositol phosphorylceramide metabolic process|protein exit from endoplasmic reticulum|vesicle fusion|CVT pathway SNAP receptor activity SNARE complex|trans-Golgi network|integral to endosome membrane
YKL090W YKL090W CUE2 hom Verified 2.02570235497886 0.0213976476153889 no 225 0.0183540555855851 121 NA Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination biological_process ubiquitin binding cellular_component
YGL072C_d YGL072C YGL072C hom Dubious 2.01559471481487 0.0219211864491588 no 226 0.0420513378072195 293 NA FF Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2 Unknown Unknown Unknown
YPL273W YPL273W SAM4 hom Verified 2.0127776440183 0.0220690134082507 no 227 0.0165182782455144 129 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM NUCLEUS S-adenosylmethionine-homocysteine methyltransferase, functions along with Mht1p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio homocysteine metabolic process|L-methionine biosynthetic process from S-adenosylmethionine|S-adenosylhomocysteine metabolic process homocysteine S-methyltransferase activity nucleus|cytoplasm
YER175W-A_p YER175W-A YER175W-A hom Uncharacterized 2.00959959432237 0.0222367921170682 no 228 0.0191435473493642 139 NA Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YGL242C_p YGL242C YGL242C hom Uncharacterized 2.00669446470644 0.0223911028897938 no 229 0.0326428311415791 119 NA Putative protein of unknown function; deletion mutant is viable biological_process molecular_function cellular_component
YER099C YER099C PRS2 hom Verified 2.00399832311012 0.022535120025966 no 230 0.0232006324830351 167 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS2 has a paralog, PRS4, that arose from the whole genome duplication fungal-type cell wall organization|5-phosphoribose 1-diphosphate biosynthetic process ribose phosphate diphosphokinase activity cytoplasm
YBR239C_p YBR239C ERT1 hom Uncharacterized 1.99137220116011 0.023219991537785 no 231 0.0170115114292204 100 NA FT TRANSCRIPTION FROM RNA POL II|SIGNALING|CARBOHYDRATE METABOLISM NUCLEUS Transcriptional regulator of nonfermentable carbon utilization; GFP-fusion protein localizes to cytoplasm, nucleus; null mutation affects periodicity of transcriptional and metabolic oscillation; plays role in restricting Ty1 transposition biological_process sequence-specific DNA binding nucleus|cytoplasm
YDL184C YDL184C RPL41A hom Verified 1.98727171775887 0.0234461470247163 no 232 0.0157948550762406 72 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L41A; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41A has a paralog, RPL41B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YDL229W YDL229W SSB1 hom Verified 1.98169850312099 0.0237564974283096 no 233 0.013085225399686 101 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RESPONSE TO NUTRIENT LEVELS Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in folding of newly-made polypeptide chains; member of the HSP70 family; interacts with phosphatase subunit Reg1p; SSB1 has a paralog, SSB2, that arose from the whole genome duplication cytoplasmic translation|cellular response to glucose starvation|translational termination|ribosomal subunit export from nucleus|regulation of translational fidelity|rRNA processing|'de novo' cotranslational protein folding unfolded protein binding|ATPase activity|calmodulin binding plasma membrane|polysome|cytoplasm
YIL025C_d YIL025C YIL025C hom Dubious 1.97977551932036 0.0238643791745422 no 234 0.0395305158726607 208 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YMR190C YMR190C SGS1 hom Verified 1.97759588157326 0.0239871571275962 no 235 0.0239530485048993 171 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Nucleolar DNA helicase of the RecQ family; involved in genome integrity maintenance; regulates chromosome synapsis and meiotic joint molecule/crossover formation; potential role as repressor of a subset of rapamycin responsive genes; rapidly lost in response to rapamycin in Rrd1p-dependent manner; similar to human BLM and WRN proteins implicated in Bloom and Werner syndromes; forms nuclear foci upon DNA replication stress DNA double-strand break processing|meiotic DNA double-strand break processing|telomeric 3' overhang formation|meiotic chromosome segregation|DNA unwinding involved in replication|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint|telomere maintenance via recombination|replicative cell aging|DNA duplex unwinding|response to DNA damage stimulus|negative regulation of meiotic joint molecule formation|chromosome organization|regulation of reciprocal meiotic recombination|gene conversion at mating-type locus, DNA double-strand break processing|mitotic sister chromatid segregation ATP-dependent DNA helicase activity RecQ helicase-Topo III complex|nucleolus
YGR222W YGR222W PET54 hom Verified 1.97226894573585 0.0242894563528101 no 236 0.031183997647029 195 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial inner membrane protein; binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing Group I intron splicing|positive regulation of mitochondrial translation|mitochondrial respiratory chain complex IV biogenesis translation regulator activity|RNA binding mitochondrion|extrinsic to mitochondrial inner membrane|mitochondrial inner membrane|mitochondrial matrix
YKR087C YKR087C OMA1 hom Verified 1.97036341274309 0.0243983678063047 no 237 0.0257808348337986 182 NA FT PROTEOLYSIS MITOCHONDRION Metalloendopeptidase of the mitochondrial inner membrane; involved in turnover of membrane-embedded proteins; mediates degradation of Cox1p in coa2 mutant cells; member of a family of predicted membrane-bound metallopeptidases in prokaryotes and higher eukaryotes misfolded or incompletely synthesized protein catabolic process metalloendopeptidase activity mitochondrion|mitochondrial inner membrane
YIR021W YIR021W MRS1 hom Verified 1.97011444261957 0.0244126280237223 no 238 0.0147733529824097 116 NA FT RNA PROCESSING MITOCHONDRION Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA Group I intron splicing endodeoxyribonuclease activity|RNA binding mitochondrion
YJL164C YJL164C TPK1 hom Verified 1.96692396956567 0.0245959883533741 no 239 0.0253731547892178 170 NA FT CELL CYCLE|SIGNALING|CELL DIVISION|PROTEIN PHOSPHORYLATION NUCLEUS cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; regulates Whi3p; partially redundant with Tpk2p and Tpk3p; TPK1 has a paralog, TPK3, that arose from the whole genome duplication protein phosphorylation|Ras protein signal transduction cAMP-dependent protein kinase activity|protein kinase activity cAMP-dependent protein kinase complex|nucleus|cytoplasm
YER122C YER122C GLO3 hom Verified 1.96370845382278 0.0247819558363114 no 240 0.0262257036693067 158 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|NUCLEOTIDE METABOLISM ENDOMEMBRANE SYSTEM|GOLGI APPARATUS ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Gcs1p retrograde vesicle-mediated transport, Golgi to ER|COPI coating of Golgi vesicle|ER to Golgi vesicle-mediated transport ARF GTPase activator activity COPI-coated vesicle|endoplasmic reticulum-Golgi intermediate compartment|COPI vesicle coat
YIR004W YIR004W DJP1 hom Verified 1.96031778886009 0.024979329050148 no 241 0.0181056487587676 118 NA FT PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION Cytosolic J-domain-containing protein, required for peroxisomal protein import and involved in peroxisome assembly, homologous to E. coli DnaJ protein import into peroxisome matrix chaperone binding cytosol
YDR275W YDR275W BSC2 hom Verified 1.95765348379638 0.0251353434770203 no 242 0.0235725421465945 138 NA Protein of unknown function; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; BSC2 has a paralog, IRC23, that arose from the whole genome duplication biological_process molecular_function lipid particle
YLR040C_p YLR040C YLR040C hom Uncharacterized 1.9556268041742 0.0252545664787002 no 243 0.0285939291496822 174 NA Protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; mRNA identified as translated by ribosome profiling data; YLR040C is not essential biological_process molecular_function fungal-type cell wall
YGL213C YGL213C SKI8 hom Verified 1.95561149518146 0.0252554688571804 no 244 0.0195842321418265 148 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE NUCLEUS|CHROMOSOME Ski complex component and WD-repeat protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; also required for meiotic double-strand break recombination; null mutants have superkiller phenotype nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|protein complex assembly|nuclear-transcribed mRNA catabolic process, non-stop decay|protein-DNA complex assembly|reciprocal meiotic recombination molecular_function Ski complex|nuclear chromosome
YOR316C-A_p YOR316C-A YOR316C-A hom Uncharacterized 1.94884543603629 0.0256569429193336 no 245 0.0166941964443818 99 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YPR120C YPR120C CLB5 hom Verified 1.94603168731087 0.0258254666966466 no 246 0.0350829188529126 220 NA FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION NUCLEUS B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase spindle assembly|G1/S transition of mitotic cell cycle|regulation of S phase of mitotic cell cycle|G2/M transition of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|positive regulation of spindle pole body separation|premeiotic DNA replication|positive regulation of DNA replication cyclin-dependent protein kinase regulator activity nucleus
YHL014C YHL014C YLF2 hom Verified 1.93847183863306 0.0262828416704132 no 247 0.0250948139192871 135 NA FT MITOCHONDRION Protein of unknown function, has weak similarity to E. coli GTP-binding protein gtp1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process GTP binding mitochondrion
YBR073W YBR073W RDH54 hom Verified 1.93262871389409 0.0266409762829918 no 248 0.0316542825270343 179 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS DNA-dependent ATPase; stimulates strand exchange by modifying the topology of double-stranded DNA; involved in recombinational repair of DNA double-strand breaks during mitosis and meiosis; proposed to be involved in crossover interference; interacts with Dmc1p; stimulates Dmc1p and Rad51p DNA geometric change|heteroduplex formation|meiotic sister chromatid segregation|reciprocal meiotic recombination|double-strand break repair via break-induced replication DNA-dependent ATPase activity|DNA translocase activity nucleus
YHR162W YHR162W MPC2 hom Verified 1.93260745445716 0.0266422867139053 no 249 0.027056617758797 170 NA Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; more highly expressed in glucose-containing minimal medium than in lactate-containing medium mitochondrial pyruvate transport pyruvate transmembrane transporter activity mitochondrion|integral to mitochondrial inner membrane
YJR035W YJR035W RAD26 hom Verified 1.92160894050804 0.0273274913890643 no 250 0.0181173655432198 132 NA FT RESPONSE TO DNA DAMAGE NUCLEUS Protein involved in transcription-coupled nucleotide excision repair of UV-induced DNA lesions; recruitment to DNA lesions is dependent on an elongating RNA polymerase II; homolog of human CSB protein transcription-coupled nucleotide-excision repair|nucleotide-excision repair DNA-dependent ATPase activity nucleus|cytoplasm
YOL116W YOL116W MSN1 hom Verified 1.92014036113535 0.0274200861715834 no 251 0.0286366212347233 157 NA FT TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM NUCLEUS Transcriptional activator; involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress; localizes to the nucleus; relative distribution to the nucleus increases upon DNA replication stress positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription from RNA polymerase II promoter in response to methylglyoxal|positive regulation of transcription from RNA polymerase II promoter in response to increased salt|Unknown|positive regulation of starch catabolic process by positive regulation of transcription from RNA polymerase II promoter|positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding nucleus
YML101C YML101C CUE4 hom Verified 1.91710427747239 0.0276123426661284 no 252 0.0100536887226011 71 NA FT ENDOPLASMIC RETICULUM Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; CUE4 has a paralog, CUE1, that arose from the whole genome duplication biological_process molecular_function endoplasmic reticulum|cytoplasm
YJL003W YJL003W COX16 hom Verified 1.9168177453583 0.0276305448637863 no 253 0.0277331040583405 141 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial inner membrane protein, required for assembly of cytochrome c oxidase mitochondrial respiratory chain complex IV assembly molecular_function mitochondrion|mitochondrial inner membrane
YIR018C-A_p YIR018C-A YIR018C-A hom Uncharacterized 1.90501506072429 0.0283890567000953 no 254 0.0240688720102417 177 NA Putative protein of unknown function; identified by expression profiling and mass spectrometry biological_process molecular_function cellular_component
YPR054W YPR054W SMK1 hom Verified 1.90393025912251 0.0284596338144848 no 255 0.0152476731019161 139 NA FT SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION MITOCHONDRION Middle sporulation-specific mitogen-activated protein kinase (MAPK) required for production of the outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p ascospore wall assembly|protein phosphorylation|negative regulation of sporulation resulting in formation of a cellular spore MAP kinase activity mitochondrion
YDR438W YDR438W THI74 hom Verified 1.90080632005945 0.0286636929806133 no 256 0.031966168513024 182 NA FT MITOCHONDRION Mitochondrial transporter repressible by thiamine; THI74 has a paralog, YML018C, that arose from the whole genome duplication biological_process molecular_function mitochondrion|integral to membrane
YKL106W YKL106W AAT1 hom Verified 1.89944434075568 0.0287530391013394 no 257 0.0205749681048118 153 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis aspartate catabolic process|chronological cell aging|replicative cell aging|asparagine biosynthetic process from oxaloacetate|aspartate biosynthetic process L-aspartate:2-oxoglutarate aminotransferase activity mitochondrion
YKL079W YKL079W SMY1 hom Verified 1.89647283973058 0.0289487740651769 no 258 0.020152435523725 127 NA FT VESICLE-MEDIATED TRANSPORT SITE OF POLARIZED GROWTH|CYTOSKELETON Protein that interacts with Myo2p, proposed to be involved in exocytosis; N-terminal domain is related to the motor domain of kinesins exocytosis motor activity incipient cellular bud site|cellular bud neck|mating projection tip|cellular bud tip
YBL055C YBL055C YBL055C hom Verified 1.88959795861811 0.0294058752023348 no 259 0.0194790095954565 134 NA FT RESPONSE TO OXIDATIVE STRESS 3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases cellular response to oxidative stress|apoptotic DNA fragmentation 3'-5'-exodeoxyribonuclease activity|endonuclease activity cytoplasm
YGR168C_p YGR168C YGR168C hom Uncharacterized 1.88818008467175 0.029500889237723 no 260 0.0518384743360487 254 NA Putative protein of unknown function; YGR168C is not an essential gene biological_process molecular_function integral to membrane
YCL049C_p YCL049C YCL049C hom Uncharacterized 1.88473617839835 0.0297327326602656 no 261 0.0282570743729175 162 NA Protein of unknown function; localizes to membrane fraction; YCL049C is not an essential gene biological_process molecular_function membrane
YGR203W YGR203W YCH1 hom Verified 1.88430090489905 0.0297621425495371 no 262 0.0282558680195317 194 NA FT NUCLEUS Phosphatase with sequence similarity to Cdc25p, Arr2p and Mih1p; member of the single-domain rhodanese homology superfamily; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus dephosphorylation phosphatase activity|protein tyrosine phosphatase activity|thiosulfate sulfurtransferase activity nucleus|cytoplasm
YNL264C YNL264C PDR17 hom Verified 1.88200816798867 0.029917453316947 no 263 0.0313248818275304 171 NA FT LIPID METABOLISM Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition Golgi to plasma membrane protein transport|phosphatidylserine metabolic process|response to drug|sterol biosynthetic process|Unknown|phospholipid transport|phospholipid biosynthetic process phosphatidylinositol transporter activity|phosphatidylcholine transporter activity endosome|cell periphery|cytosol|cytoplasm
YBR196C-B_p YBR196C-B YBR196C-B hom Uncharacterized 1.87359257246538 0.0304933012837628 no 264 0.0238877718305271 157 NA Putative protein of unknown function; identified by expression profiling and mass spectrometry biological_process molecular_function cellular_component
YOR076C YOR076C SKI7 hom Verified 1.87099532073259 0.0306728648004762 no 265 0.0341760980606959 181 NA FT TRANSLATION|NUCLEOTIDE METABOLISM Coupling protein that mediates interactions between the Ski complex and the cytoplasmic exosome during 3'-5' RNA degradation; eRF3-like domain targets nonstop mRNA for degradation; null mutants have superkiller phenotype nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, non-stop decay|nonfunctional rRNA decay protein binding, bridging Ski complex|cytoplasmic exosome (RNase complex)|cytoplasm
YNR025C_d YNR025C YNR025C hom Dubious 1.86540288550726 0.0310624766080613 no 266 0.0256391500058296 182 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion reduces expression of PIS1 gene encoding phosphatidylinositol synthase Unknown Unknown Unknown
YOR350C YOR350C MNE1 hom Verified 1.85822530033057 0.0315685133007149 no 267 0.0320186928741922 176 NA FT RNA PROCESSING MITOCHONDRION Mitochondrial matrix protein involved in splicing Group I aI5-beta intron from COX1 mRNA Group I intron splicing molecular_function mitochondrion|ribonucleoprotein complex|mitochondrial matrix
YJR131W YJR131W MNS1 hom Verified 1.85735619723603 0.0316302470063841 no 268 0.0329594298754998 137 NA FT CARBOHYDRATE METABOLISM|PROTEOLYSIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Alpha-1,2-mannosidase involved in ER-associated protein degradation (ERAD); catalyzes the removal of one mannose residue from a glycosylated protein, converting the modification from Man9GlcNAc to Man8GlcNAc; catalyzes the last step in glycoprotein maturation in the ER and is critical for ER protein degradation ER-associated protein catabolic process|protein deglycosylation involved in glycoprotein catabolic process mannosyl-oligosaccharide 1,2-alpha-mannosidase activity endoplasmic reticulum
YNL279W YNL279W PRM1 hom Verified 1.85580767602522 0.0317404880379336 no 269 0.0320262716450069 174 NA FT MEMBRANE ORGANIZATION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p plasma membrane fusion involved in cytogamy|response to pheromone molecular_function integral to membrane|mating projection tip
YER026C YER026C CHO1 hom Verified 1.8490471321288 0.0322255036486189 no 270 0.0397099218147841 204 NA FT LIPID METABOLISM ENDOPLASMIC RETICULUM|MITOCHONDRION Phosphatidylserine synthase, functions in phospholipid biosynthesis; catalyzes the reaction CDP-diaclyglycerol + L-serine = CMP + L-1-phosphatidylserine, transcriptionally repressed by myo-inositol and choline phosphatidylserine biosynthetic process CDP-diacylglycerol-serine O-phosphatidyltransferase activity mitochondrial outer membrane|integral to membrane|endoplasmic reticulum
YLR240W YLR240W VPS34 hom Verified 1.84378042772899 0.0326075731079464 no 271 0.0352738571609262 219 NA FT PROTEIN LOCALIZATION|LIPID METABOLISM|SIGNALING|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION GOLGI APPARATUS Phosphatidylinositol (PI) 3-kinase that synthesizes PI-3-phosphate; forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting; activated by the GTP-bound form of Gpa1p; a fraction is localized, with Vps15p, to nuclear pores at nucleus-vacuole junctions and may facilitate transcription elongation for genes positioned at the nuclear periphery peroxisome degradation|phosphatidylinositol phosphorylation|protein phosphorylation 1-phosphatidylinositol-3-kinase activity|protein kinase activity endosome|fungal-type vacuole membrane|phosphatidylinositol 3-kinase complex I|phosphatidylinositol 3-kinase complex II|peroxisome|pre-autophagosomal structure
YLR417W YLR417W VPS36 hom Verified 1.84373009754713 0.0326112422199315 no 272 0.0720675513500703 398 NA FF|FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome negative regulation of transcription from RNA polymerase II promoter by glucose|protein retention in Golgi apparatus|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein targeting to vacuole ubiquitin binding ESCRT II complex
YOR142W YOR142W LSC1 hom Verified 1.84336708212739 0.0326377164309598 no 273 0.0244274839122934 170 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Alpha subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated tricarboxylic acid cycle|succinyl-CoA metabolic process succinate-CoA ligase (ADP-forming) activity mitochondrial nucleoid|mitochondrion
YGL257C YGL257C MNT2 hom Verified 1.83498560976249 0.0332539108338256 no 274 0.0315668618523838 125 NA FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans protein O-linked glycosylation alpha-1,3-mannosyltransferase activity cellular_component
YPL071C_p YPL071C YPL071C hom Uncharacterized 1.83483100908457 0.0332653662510523 no 275 0.0272669919260914 142 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus biological_process molecular_function nucleus|cytoplasm
YNL056W YNL056W OCA2 hom Verified 1.83082889087719 0.0335630433326939 no 276 0.0319136020324392 169 NA Putative protein with similarity to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene biological_process molecular_function cytoplasm
YJL139C YJL139C YUR1 hom Verified 1.8284307346326 0.0337424661078086 no 277 0.0363183790328769 202 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Mannosyltransferase involved in protein N-glycosylation; member of the KTR1 family; located in the Golgi apparatus; YUR1 has a paralog, KTR2, that arose from the whole genome duplication cell wall mannoprotein biosynthetic process|protein N-linked glycosylation mannosyltransferase activity Golgi apparatus
YLL063C YLL063C AYT1 hom Verified 1.82836976059238 0.0337470382687083 no 278 0.0215569714429292 136 NA Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis secondary metabolic process trichothecene 3-O-acetyltransferase activity cellular_component
YHL046C YHL046C PAU13 hom Verified 1.82827065179321 0.0337544710662516 no 279 0.0228954762094794 143 NA Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; expression is induced after ethanol shock biological_process molecular_function cellular_component
YOR096W YOR096W RPS7A hom Verified 1.82579343678287 0.0339406911551097 no 280 0.0543818304423177 237 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION NUCLEUS RIBOSOME Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7A has a paralog, RPS7B, that arose from the whole genome duplication cytoplasmic translation|ribosome biogenesis structural constituent of ribosome small-subunit processome|cytosolic small ribosomal subunit|90S preribosome
YKR012C_d YKR012C YKR012C hom Dubious 1.82430647915139 0.034052875725006 no 281 0.016998989880697 117 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PRY2 Unknown Unknown Unknown
YMR182C YMR182C RGM1 hom Verified 1.82322813832243 0.034134422505605 no 282 0.0315706375834957 160 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS|CHROMOSOME Putative zinc finger DNA binding transcription factor; contains two N-terminal C2H2 zinc fingers and C-terminal proline rich domain; overproduction impairs cell growth and induces expression of genes involved in monosaccharide catabolism and aldehyde metabolism; regulates expression of of Y-prime telomeric elements and subtelomeric COS genes; RGM1 has a paralog, USV1, that arose from the whole genome duplication positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity nuclear chromatin
YDR400W YDR400W URH1 hom Verified 1.82244921224036 0.0341934266249345 no 283 0.0264059791723496 127 NA FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM NUCLEUS Uridine nucleosidase (uridine-cytidine N-ribohydrolase), cleaves N-glycosidic bonds in nucleosides; involved in the pyrimidine salvage and nicotinamide riboside salvage pathways pyrimidine-containing compound salvage|NAD biosynthesis via nicotinamide riboside salvage pathway|pyrimidine nucleoside catabolic process|nicotinate nucleotide salvage ribosylpyrimidine nucleosidase activity|nicotinic acid riboside hydrolase activity|nicotinamide riboside hydrolase activity|uridine nucleosidase activity nucleus|cytoplasm
YBR021W YBR021W FUR4 hom Verified 1.81219218828845 0.0349782528393133 no 284 0.0756485861100515 385 NA FF|FT PLASMA MEMBRANE Plasma membrane localized uracil permease; expression is tightly regulated by uracil levels and environmental cues; conformational alterations induced by unfolding or substrate binding result in Rsp5p-mediated ubiquitination and degradation uracil transport|transmembrane transport uracil:cation symporter activity integral to membrane|membrane raft|plasma membrane
YOR015W_d YOR015W YOR015W hom Dubious 1.81169125829897 0.0350169575546575 no 285 0.0285608543226665 178 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YEL033W_p YEL033W MTC7 hom Uncharacterized 1.80950780507639 0.0351860743438975 no 286 0.0599985334185839 278 NA Predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant biological_process molecular_function cellular_component
YLR067C YLR067C PET309 hom Verified 1.80844545487742 0.0352685994242495 no 287 0.0395005267243621 223 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Specific translational activator for the COX1 mRNA, also influences stability of intron-containing COX1 primary transcripts; localizes to the mitochondrial inner membrane; contains seven pentatricopeptide repeats (PPRs) positive regulation of mitochondrial translational initiation|RNA metabolic process|mitochondrial respiratory chain complex IV biogenesis|aerobic respiration translation regulator activity extrinsic to mitochondrial inner membrane|mitochondrion|integral to membrane|mitochondrial inner membrane
YML050W YML050W AIM32 hom Verified 1.80063163151409 0.0358804800455172 no 288 0.0468741267331479 210 NA Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss biological_process molecular_function cellular_component
YDR018C_p YDR018C YDR018C hom Uncharacterized 1.79942075999688 0.0359760740489441 no 289 0.0320439464022975 172 NA FT LIPID METABOLISM Probable membrane protein with three predicted transmembrane domains; similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase; YDR018C has a paralog, CST26, that arose from the whole genome duplication phospholipid biosynthetic process transferase activity, transferring acyl groups integral to membrane
YOL088C YOL088C MPD2 hom Verified 1.79907659281984 0.0360032828665411 no 290 0.0718573084631692 351 NA FT ENDOPLASMIC RETICULUM Member of the protein disulfide isomerase (PDI) family, exhibits chaperone activity; overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions; undergoes oxidation by Ero1p protein folding protein disulfide isomerase activity|protein disulfide oxidoreductase activity endoplasmic reticulum
YGL079W_p YGL079W KXD1 hom Uncharacterized 1.78887601688637 0.036817392510696 no 291 0.0284018614403847 170 NA Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; GFP-fusion protein localizes to the endosome biological_process molecular_function endosome
YDR541C_p YDR541C YDR541C hom Uncharacterized 1.78387998954867 0.0372215840624375 no 292 0.0422462592297742 208 NA FT OXIDATION-REDUCTION PROCESS Putative dihydrokaempferol 4-reductase biological_process carbonyl reductase (NADPH) activity cellular_component
YAL019W YAL019W FUN30 hom Verified 1.77967805228997 0.037564332163115 no 293 0.0342245625761823 194 NA FT CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|MITOCHONDRION|CHROMOSOME Snf2p family member with ATP-dependent chromatin remodeling activity; has a role in silencing at the mating type locus, telomeres and centromeres; enriched at centromeres and is required for correct chromatin structure around centromeres, as well as at the boundary element of the silent HMR; recruited to DNA double-strand breaks (DSBs) where it promotes 5' strand resection of DSBs; potential Cdc28p substrate chromosome organization|chromatin silencing at rDNA|heterochromatin maintenance involved in chromatin silencing|chromatin silencing at telomere|chromatin silencing at silent mating-type cassette|heterochromatin assembly involved in chromatin silencing chromatin binding|DNA-dependent ATPase activity|DNA binding|protein homodimerization activity mitochondrion|mating-type region heterochromatin|nucleus
YDR340W_d YDR340W YDR340W hom Dubious 1.77914105672437 0.037608319515563 no 294 0.0256098334536179 142 NA Putative protein of unknown function Unknown Unknown Unknown
YGR155W YGR155W CYS4 hom Verified 1.77660392280457 0.0378167148863048 no 295 0.0452028830302263 267 NA FT KETONE METABOLISM|CELL CYCLE|AMINO ACID METABOLISM MITOCHONDRION Cystathionine beta-synthase, catalyzes synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis; responsible for hydrogen sulfide generation; advances passage through START by promoting cell growth which requires catalytic activity, and reducing critical cell size independent of catalytic activity; mutations in human ortholog cause homocystinuria cysteine biosynthetic process from serine|hydrogen sulfide biosynthetic process|cysteine biosynthetic process via cystathionine|transsulfuration|traversing start control point of mitotic cell cycle cystathionine beta-synthase activity mitochondrion|cytoplasm
YMR255W YMR255W GFD1 hom Verified 1.77308102678942 0.0381076407106056 no 296 0.032861198709778 197 NA FT PROTEIN LOCALIZATION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE Coiled-coiled protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; protein abundance increases in response to DNA replication stress mRNA export from nucleus molecular_function integral to membrane|nuclear pore|cytoplasm
YKR046C YKR046C PET10 hom Verified 1.77042274357643 0.038328371874939 no 297 0.0326134173546298 192 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY Protein of unknown function that co-purifies with lipid particles; expression pattern suggests a role in respiratory growth; computational analysis of large-scale protein-protein interaction data suggests a role in ATP/ADP exchange aerobic respiration molecular_function lipid particle
YGR290W_d YGR290W YGR290W hom Dubious 1.76921226620491 0.0384292289765383 no 298 0.0427898786379936 247 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; putative HLH protein; partially overlaps the verified ORF MAL11/YGR289C (a high-affinity maltose transporter) Unknown Unknown Unknown
YBL062W_d YBL062W YBL062W hom Dubious 1.7669515162268 0.0386181741751319 no 299 0.0525180501513009 248 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YMR201C YMR201C RAD14 hom Verified 1.76381267586554 0.0388817613274539 no 300 0.0436666327080913 212 NA FT RESPONSE TO DNA DAMAGE NUCLEUS Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein nucleotide-excision repair, DNA damage recognition damaged DNA binding|zinc ion binding nucleotide-excision repair factor 1 complex|nucleus
YPL046C YPL046C ELC1 hom Verified 1.75394848645776 0.0397196671848526 no 301 0.0271301847585688 182 NA FT RESPONSE TO DNA DAMAGE|PROTEOLYSIS NUCLEUS UBIQUITIN LIGASE COMPLEX Elongin C, conserved among eukaryotes; forms a complex with Cul3p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; plays a role in global genomic repair global genome nucleotide-excision repair|protein ubiquitination involved in ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity elongin complex|Cul3-RING ubiquitin ligase complex
YOR378W_p YOR378W YOR378W hom Uncharacterized 1.75362137135432 0.0397477032800693 no 302 0.0273850773655802 116 NA FT PLASMA MEMBRANE Putative paralog of ATR1, but not required for boron tolerance; member of the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene biological_process molecular_function integral to membrane
YGL042C_d YGL042C YGL042C hom Dubious 1.75098720816561 0.0399740567352587 no 303 0.0399419566246361 202 NA Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene DST1 Unknown Unknown Unknown
YML075C YML075C HMG1 hom Verified 1.74926085171059 0.0401229698530907 no 304 0.0395320017921771 243 NA FT LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM HMG-CoA reductase; catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to the nuclear envelope; overproduction induces the formation of karmellae; forms foci at the nuclear periphery upon DNA replication stress ergosterol biosynthetic process|isopentenyl diphosphate biosynthetic process, mevalonate pathway hydroxymethylglutaryl-CoA reductase (NADPH) activity nuclear envelope|integral to membrane|endoplasmic reticulum membrane
YPR171W YPR171W BSP1 hom Verified 1.74559503467921 0.0404406728345752 no 305 0.0414380474000832 220 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON Adapter that links synaptojanins Inp52p and Inp53p to the cortical actin cytoskeleton actin cortical patch localization protein binding, bridging mating projection tip|membrane|cellular bud neck|actin cortical patch|cellular bud tip
YBR077C YBR077C SLM4 hom Verified 1.73833796622396 0.0410756401456856 no 306 0.0599336949017567 295 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|SIGNALING Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4 signal transduction|microautophagy phosphatidylinositol-3,4-bisphosphate binding fungal-type vacuole membrane|EGO complex|late endosome membrane|cytoplasm
YKL074C YKL074C MUD2 hom Verified 1.73773482121527 0.0411287750418722 no 307 0.0303243286098287 172 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING NUCLEUS Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65 mRNA branch site recognition pre-mRNA branch point binding commitment complex
YGR037C YGR037C ACB1 hom Verified 1.73407368278557 0.0414525051695995 no 308 0.10948797932396 486 NA FF|FT KETONE METABOLISM|LIPID METABOLISM NUCLEUS Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion; protein abundance increases in response to DNA replication stress long-chain fatty acid transport|chronological cell aging|fatty acid metabolic process long-chain fatty acid transporter activity|fatty-acyl-CoA binding extracellular region|nucleus|cytoplasm
YOR331C_d YOR331C YOR331C hom Dubious 1.72973363828474 0.0418389378873651 no 309 0.0660668483916664 248 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene VMA4/YOR332W Unknown Unknown Unknown
YOL163W_p YOL163W YOL163W hom Uncharacterized 1.72617657122355 0.0421578258149162 no 310 0.0337766275126355 144 NA Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family transmembrane transport transmembrane transporter activity integral to membrane|membrane
YAL059W YAL059W ECM1 hom Verified 1.72451454092107 0.0423074981180019 no 311 0.0308529018369754 155 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|CELL WALL ORG/BIOGENESIS NUCLEUS Pre-ribosomal factor involved in 60S ribosomal protein subunit export; associates with the pre-60S particle; shuttles between the nucleus and cytoplasm fungal-type cell wall organization|ribosomal large subunit export from nucleus molecular_function nucleolus|nucleus|preribosome, large subunit precursor
YDR529C YDR529C QCR7 hom Verified 1.72248782199027 0.0424905934792777 no 312 0.0611332245194789 312 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Subunit 7 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the mitochondrial matrix; N-terminus appears to play a role in complex assembly mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration|mitochondrial respiratory chain complex III assembly ubiquinol-cytochrome-c reductase activity mitochondrion|integral to membrane|mitochondrial respiratory chain complex III
YPR118W YPR118W MRI1 hom Verified 1.72128611669687 0.0425994587557686 no 313 0.0505589562386599 178 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS 5'-methylthioribose-1-phosphate isomerase; catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway L-methionine salvage from methylthioadenosine S-methyl-5-thioribose-1-phosphate isomerase activity nucleus|cytoplasm
YDR532C YDR532C KRE28 hom Verified 1.71747723752131 0.0429460049819879 no 314 0.0624891960857152 199 NA FT ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME|CYTOSKELETON KINETOCHORE Subunit of a kinetochore-microtubule binding complex with Spc105p that bridges centromeric heterochromatin and kinetochore MAPs and motors, and is also required for sister chromatid bi-orientation and kinetochore binding of SAC components biological_process molecular_function chromosome, centromeric region|condensed nuclear chromosome kinetochore|spindle pole body
YGR268C YGR268C HUA1 hom Verified 1.71423828045273 0.0432424865515881 no 315 0.0547892353906236 251 NA Cytoplasmic protein containing a zinc finger domain with sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly biological_process molecular_function cytoplasm
YDR073W YDR073W SNF11 hom Verified 1.71347363507492 0.0433127198517572 no 316 0.0318561351635614 171 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS RSC COMPLEX Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p; relocates to the cytosol under hypoxic conditions positive regulation of transcription from RNA polymerase II promoter molecular_function SWI/SNF complex
YJR003C_p YJR003C YJR003C hom Uncharacterized 1.71243951330042 0.0434078512674629 no 317 0.0444884854081041 192 NA FT MITOCHONDRION Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; predicted to be involved in ribosome biogenesis biological_process molecular_function mitochondrion
YLR109W YLR109W AHP1 hom Verified 1.71009418016864 0.04362422940842 no 318 0.0391632552656547 203 NA FT OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p cellular response to oxidative stress|response to metal ion|cell redox homeostasis thioredoxin peroxidase activity plasma membrane|cytoplasm
YDR476C_p YDR476C YDR476C hom Uncharacterized 1.70850089076227 0.0437717206219775 no 319 0.034640056868826 190 NA FT ENDOPLASMIC RETICULUM Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR476C is not an essential gene biological_process molecular_function endoplasmic reticulum
YEL029C YEL029C BUD16 hom Verified 1.70554676747534 0.0440462488757959 no 320 0.0820242922119298 350 NA FT CELL CYCLE|CELL DIVISION|COFACTOR METABOLISM NUCLEUS Putative pyridoxal kinase, a key enzyme involved in pyridoxal 5'-phosphate synthesis, the active form of vitamin B6; required for genome integrity; involved in bud-site selection; similarity to yeast BUD17 and human pyridoxal kinase (PDXK) pyridoxal phosphate biosynthetic process|cellular bud site selection pyridoxal kinase activity cytoplasm
YML063W YML063W RPS1B hom Verified 1.70370029950376 0.0442185460823524 no 321 0.0546209721040293 241 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal protein 10 (rp10) of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1B has a paralog, RPS1A, that arose from the whole genome duplication cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit|90S preribosome
YGR234W YGR234W YHB1 hom Verified 1.70356938261785 0.0442307827659862 no 322 0.0283649610132019 161 NA FT OXIDATION-REDUCTION PROCESS MITOCHONDRION Nitric oxide oxidoreductase; flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress response to stress nitric oxide reductase activity cytosol|mitochondrion|mitochondrial matrix|cytoplasm
YER016W YER016W BIM1 hom Verified 1.70030554140999 0.0445367343329916 no 323 0.0399743103724026 240 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION CHROMOSOME|CYTOSKELETON KINETOCHORE Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally nuclear migration along microtubule|microtubule nucleation|microtubule depolymerization|negative regulation of microtubule depolymerization|positive regulation of microtubule polymerization|mitotic sister chromatid cohesion|mitotic cell cycle spindle assembly checkpoint microtubule plus-end binding|protein homodimerization activity|structural constituent of cytoskeleton spindle midzone|microtubule plus end|cytoplasmic microtubule|spindle pole body|kinetochore|spindle pole|spindle
YCR094W YCR094W CDC50 hom Verified 1.69919325046625 0.0446413888530722 no 324 0.084319711780253 501 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION GOLGI APPARATUS Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Lem3p; CDC50 has a paralog, YNR048W, that arose from the whole genome duplication intracellular protein transport|phospholipid translocation|endocytosis|actin cortical patch localization phospholipid-translocating ATPase activity trans-Golgi network|late endosome membrane
YNL084C YNL084C END3 hom Verified 1.69766131880892 0.0447858511813629 no 325 0.0738083300134589 355 NA FF|FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p bipolar cellular bud site selection|ascospore wall assembly|endocytosis|actin filament organization|cytokinesis|actin cortical patch assembly protein binding, bridging mating projection tip|actin cortical patch
YGL124C YGL124C MON1 hom Verified 1.69488942856797 0.0450481991533777 no 326 0.05637741494621 282 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT Protein required for fusion of cvt-vesicles and autophagosomes with the vacuole; associates, as a complex with Ccz1p, with a perivacuolar compartment; potential Cdc28p substrate autophagy|vesicle docking|protein targeting to vacuole molecular_function cytosol|fungal-type vacuole membrane|Mon1-Ccz1 complex
YGR223C YGR223C HSV2 hom Verified 1.69271167279576 0.0452551811562024 no 327 0.0500986077091078 250 NA FT MEMBRANE ORGANIZATION|RESPONSE TO NUTRIENT LEVELS Phosphatidylinositol 3,5-bisphosphate-binding protein, plays a role in micronucleophagy; belongs to the PROPPIN family of proteins; predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization piecemeal microautophagy of nucleus phosphatidylinositol binding endosome|fungal-type vacuole|extrinsic to membrane|cytoplasm
YPR042C YPR042C PUF2 hom Verified 1.68881208383852 0.0456277236880953 no 328 0.0532961579970346 292 NA Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding membrane-associated proteins nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay mRNA binding cytoplasm
YGR076C YGR076C MRPL25 hom Verified 1.6883838884915 0.0456687806086952 no 329 0.0572086076046613 273 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit; mutation confers increased replicative lifespan mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YOL008W YOL008W COQ10 hom Verified 1.6842715621092 0.0460645993349571 no 330 0.0455738114904257 223 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Coenzyme Q (ubiquinone) binding protein, functions in the delivery of Q6 to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes cellular respiration ubiquinone binding mitochondrion|mitochondrial inner membrane
YMR222C YMR222C FSH2 hom Verified 1.68258085492989 0.0462281302336228 no 331 0.0386859387173609 191 NA Putative serine hydrolase that localizes to the cytoplasm; sequence is similar to S. cerevisiae Fsh1p and Fsh3p and the human candidate tumor suppressor OVCA2 biological_process molecular_function cytoplasm
YDR463W YDR463W STP1 hom Verified 1.6779288643783 0.0466804934335082 no 332 0.111610851746707 377 NA FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS|PLASMA MEMBRANE Transcription factor; undergoes proteolytic processing by SPS (Ssy1p-Ptr3p-Ssy5p)-sensor component Ssy5p in response to extracellular amino acids; activates transcription of amino acid permease genes and may have a role in tRNA processing; STP1 has a paralog, STP2, that arose from the whole genome duplication positive regulation of transcription, DNA-dependent|tRNA splicing, via endonucleolytic cleavage and ligation|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription plasma membrane|nucleus|cytoplasm
YNL206C YNL206C RTT106 hom Verified 1.67633230092783 0.046836560670155 no 333 0.0577922215296163 257 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Histone chaperone, involved in regulation of chromatin structure in both transcribed and silenced chromosomal regions; affects transcriptional elongation; has a role in regulation of Ty1 transposition DNA replication-independent nucleosome assembly|negative regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|DNA replication-dependent nucleosome assembly|heterochromatin assembly involved in chromatin silencing double-stranded DNA binding|histone binding nucleus
YOR385W_p YOR385W YOR385W hom Uncharacterized 1.67583482853084 0.046885275012907 no 334 0.0482600495695286 265 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YOR385W is not an essential gene biological_process molecular_function cytoplasm
YHR075C YHR075C PPE1 hom Verified 1.67385691410876 0.0470793618477253 no 335 0.0444418613217457 225 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Protein with carboxyl methyl esterase activity that may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein cellular protein modification process|mitochondrial translation structural constituent of ribosome|carboxylesterase activity mitochondrial small ribosomal subunit
YAL037C-A_p YAL037C-A YAL037C-A hom Uncharacterized 1.67253761548654 0.0472091784342567 no 336 0.0487563089696516 234 NA Putative protein of unknown function biological_process molecular_function cellular_component
YPR001W YPR001W CIT3 hom Verified 1.65956908906006 0.048500585537804 no 337 0.0611984957391623 278 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate propionate catabolic process, 2-methylcitrate cycle|propionate metabolic process|tricarboxylic acid cycle 2-methylcitrate synthase activity|citrate (Si)-synthase activity mitochondrion
YJR099W YJR099W YUH1 hom Verified 1.65917444585106 0.0485403226765508 no 338 0.0349517734747417 141 NA FT PROTEOLYSIS Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p protein deubiquitination ubiquitin-specific protease activity cytoplasm
YKR049C YKR049C FMP46 hom Verified 1.65913167651153 0.0485446307400821 no 339 0.041370912713396 206 NA FT OXIDATION-REDUCTION PROCESS MITOCHONDRION Putative redox protein containing a thioredoxin fold; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process oxidoreductase activity mitochondrion
YAL026C YAL026C DRS2 hom Verified 1.65812447658315 0.048646172222045 no 340 0.0656260176339828 344 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RIBOSOME BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS GOLGI APPARATUS Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation and endocytosis; mutations in human homolog ATP8B1 result in liver disease intracellular protein transport|post-Golgi vesicle-mediated transport|phospholipid translocation|endocytosis|ribosomal small subunit assembly phospholipid-translocating ATPase activity trans-Golgi network|integral to membrane
YDR307W_p YDR307W PMT7 hom Uncharacterized 1.65495408642148 0.0489669058439599 no 341 0.0434989269100992 195 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Putative protein mannosyltransferase similar to Pmt1p; has a potential role in protein O-glycosylation biological_process molecular_function integral to membrane|endoplasmic reticulum
YCL061C YCL061C MRC1 hom Verified 1.64810242901097 0.0496658269805369 no 342 0.0664944278309314 338 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|GENE SILENCING NUCLEUS|CHROMOSOME S-phase checkpoint protein required for DNA replication; interacts with and stabilizes Pol2p at stalled replication forks during stress, where it forms a pausing complex with Tof1p and is phosphorylated by Mec1p; protects uncapped telomeres maintenance of DNA repeat elements|intra-S DNA damage checkpoint|DNA repair|DNA replication checkpoint|telomere maintenance|replication fork protection|DNA replication|mitotic sister chromatid cohesion|chromatin silencing at silent mating-type cassette|chromatin silencing at telomere molecular_function nuclear chromosome|replication fork protection complex|nucleus|nuclear replication fork
YFL019C_d YFL019C YFL019C hom Dubious 1.64803729827463 0.0496725088038912 no 343 0.0326919313061112 245 NA Dubious open reading frame unlikely to encode a protein; YFL019C is not an essential gene Unknown Unknown Unknown
YNR005C_d YNR005C YNR005C hom Dubious 1.64650758034605 0.049829650359341 no 344 0.0686493054644811 331 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YBL053W_d YBL053W YBL053W hom Dubious 1.64640630696291 0.0498400677319723 no 345 0.0451701653336536 199 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YHR012W YHR012W VPS29 hom Verified 1.64036911251505 0.0504642217458138 no 346 0.0664354504785069 356 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval retrograde transport, endosome to Golgi protein transporter activity endosome|retromer complex, inner shell|retromer complex
YOR324C YOR324C FRT1 hom Verified 1.64007989253337 0.050494278302934 no 347 0.0583850281612169 252 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Tail-anchored ER membrane protein of unknown function; substrate of the phosphatase calcineurin; interacts with homolog Frt2p; promotes cell growth in stress conditions, possibly via a role in posttranslational translocation; FRT1 has a paralog, FRT2, that arose from the whole genome duplication response to stress molecular_function endoplasmic reticulum
YCR026C YCR026C NPP1 hom Verified 1.63691597422181 0.0508240138435473 no 348 0.0647312581181083 309 NA FT NUCLEOTIDE METABOLISM|RESPONSE TO NUTRIENT LEVELS Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; NPP1 has a paralog, NPP2, that arose from the whole genome duplication cellular response to phosphate starvation|phosphate-containing compound metabolic process|nucleoside triphosphate metabolic process nucleotide diphosphatase activity|nucleoside-triphosphate diphosphatase activity|nucleoside-triphosphatase activity|phosphodiesterase I activity cellular_component
YIL086C_d YIL086C YIL086C hom Dubious 1.63667934492818 0.0508487434937356 no 349 0.0389438992017191 196 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YNL300W_p YNL300W TOS6 hom Uncharacterized 1.63567504647097 0.0509538073324976 no 350 0.0662390971173467 328 NA Glycosylphosphatidylinositol-dependent cell wall protein, expression is periodic and decreases in respone to ergosterol perturbation or upon entry into stationary phase; depletion increases resistance to lactic acid biological_process molecular_function fungal-type cell wall
YGR209C YGR209C TRX2 hom Verified 1.63546660659866 0.0509756347338436 no 351 0.0360402045502125 138 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p; required for ER-Golgi transport and vacuole inheritance; protein abundance increases in response to DNA replication stress vacuole inheritance|regulation of DNA replication|cell redox homeostasis|protein deglutathionylation|sulfate assimilation|retrograde vesicle-mediated transport, Golgi to ER|cellular response to oxidative stress|ER to Golgi vesicle-mediated transport|vacuole fusion, non-autophagic disulfide oxidoreductase activity cytosol|fungal-type vacuole
YPL245W_p YPL245W YPL245W hom Uncharacterized 1.63440756462847 0.0510866504618186 no 352 0.0491876259819385 217 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm biological_process molecular_function nucleus|cytoplasm
YBR169C YBR169C SSE2 hom Verified 1.63279501058096 0.0512560583980358 no 353 0.0296915277304476 109 NA Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication protein folding|protein refolding adenyl-nucleotide exchange factor activity cytoplasm
YNR012W YNR012W URK1 hom Verified 1.63244390017054 0.051293003721147 no 354 0.0587310920848307 281 NA FT NUCLEOTIDE METABOLISM NUCLEUS Uridine/cytidine kinase, component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP; involved in the pyrimidine deoxyribonucleotide salvage pathway, converting deoxycytidine into dCMP pyrimidine-containing compound salvage uridine kinase activity nucleus|cytoplasm
YFR035C_p YFR035C YFR035C hom Uncharacterized 1.63217330409473 0.0513214914377902 no 355 0.047133949070357 254 NA Putative protein of unknown function, deletion mutant exhibits synthetic phenotype with alpha-synuclein biological_process molecular_function cellular_component
YNL081C YNL081C SWS2 hom Verified 1.63165315569289 0.0513762867830378 no 356 0.0908472066787041 389 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency regulation of sporulation resulting in formation of a cellular spore|mitochondrial translation structural constituent of ribosome mitochondrial small ribosomal subunit|cytoplasm
YFL001W YFL001W DEG1 hom Verified 1.62964438530702 0.0515883389054514 no 357 0.074526876980886 273 NA FT RNA PROCESSING NUCLEUS tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm; non-essential for viability tRNA pseudouridine synthesis pseudouridine synthase activity nucleus|cytoplasm
YBR069C YBR069C TAT1 hom Verified 1.62915396406104 0.0516402148587704 no 358 0.212964264268507 714 NA FF|FT PLASMA MEMBRANE Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress amino acid transport|tyrosine transport|tryptophan transport|transmembrane transport amino acid transmembrane transporter activity|low-affinity tryptophan transmembrane transporter activity integral to membrane|plasma membrane
YMR244C-A YMR244C-A COA6 hom Verified 1.62838119328578 0.0517220414331279 no 359 0.0396879993667528 196 NA FT NUCLEUS|MITOCHONDRION Protein involved in cytochrome c oxidase assembly; also required for efficient formation of respiratory supercomplexes comprised of Complexes III and IV; localizes to the mitochondrial intermembrane space; has a human homolog; transcription is induced in response to the DNA-damaging agent MMS; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus|cytoplasm
YML059C YML059C NTE1 hom Verified 1.6241062002318 0.052176572468132 no 360 0.0511018727949695 210 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Serine esterase, homolog of human neuropathy target esterase (NTE); Nte1p-mediated phosphatidylcholine turnover influences transcription factor Opi1p localization, affecting transcriptional regulation of phospholipid biosynthesis genes phosphatidylcholine catabolic process|regulation of phospholipid biosynthetic process lysophospholipase activity|carboxylesterase activity integral to membrane|endoplasmic reticulum
YPL102C_d YPL102C YPL102C hom Dubious 1.6181243638275 0.0528178994288863 no 361 0.0535362868161761 263 NA Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation enhances replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene ELP4 Unknown Unknown Unknown
YML120C YML120C NDI1 hom Verified 1.61715345020277 0.0529225808049412 no 362 0.0337024606992748 175 NA FT OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION NADH:ubiquinone oxidoreductase; transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; involved in Mn and H2O2 induced apoptosis; upon apoptotic stress, Ndip is activated in the mitochondria by N-terminal cleavage, and the truncated protein translocates to the cytoplasm to induce apoptosis; homolog of human AMID mitochondrial electron transport, NADH to ubiquinone|NADH oxidation|chronological cell aging|positive regulation of apoptotic process NADH dehydrogenase (ubiquinone) activity mitochondrion|mitochondrial matrix
YGL140C_p YGL140C YGL140C hom Uncharacterized 1.61346919321618 0.053321305501964 no 363 0.0263228839764814 154 NA Putative protein of unknown function; non-essential gene; contains multiple predicted transmembrane domains biological_process molecular_function integral to membrane
YMR246W YMR246W FAA4 hom Verified 1.61306665915264 0.0533650132112311 no 364 0.0497468548102008 251 NA FT KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM Long chain fatty acyl-CoA synthetase; activates imported fatty acids with a preference for C12:0-C16:0 chain lengths; functions in long chain fatty acid import; important for survival during stationary phase; localized to lipid particles; involved in sphingolipid-to-glycerolipid metabolism; forms cytoplasmic foci upon DNA replication stress; FAA4 has a paralog, FAA1, that arose from the whole genome duplication long-chain fatty acid transport|long-chain fatty-acyl-CoA metabolic process long-chain fatty acid-CoA ligase activity lipid particle|cytoplasm
YLR292C YLR292C SEC72 hom Verified 1.61176796006281 0.0535062213737155 no 365 0.069549072124005 318 NA FT PROTEIN LOCALIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER posttranslational protein targeting to membrane, translocation protein transporter activity Sec62/Sec63 complex|endoplasmic reticulum membrane
YNL063W YNL063W MTQ1 hom Verified 1.61113567313162 0.0535750773009758 no 366 0.0568662176118883 252 NA FT TRANSLATION MITOCHONDRION S-adenosylmethionine-dependent methyltransferase; methylates translational release factor Mrf1p; similar to E.coli PrmC; is not an essential gene translational readthrough S-adenosylmethionine-dependent methyltransferase activity mitochondrion
YFR024C-A YFR024C-A LSB3 hom Verified 1.60605499151467 0.0541309139258251 no 367 0.0477432658629434 234 NA FT MITOCHONDRION|SITE OF POLARIZED GROWTH Protein containing a C-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein abundance increases in response to DNA replication stress; LSB3 has a paralog, YSC84, that arose from the whole genome duplication actin cortical patch localization molecular_function mitochondrion|cellular bud neck|cytoplasm
YLR015W YLR015W BRE2 hom Verified 1.60338840937512 0.0544244641949646 no 368 0.083644576007377 366 NA FT CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Subunit of COMPASS (Set1C) complex, which methylates Lys4 of histone H3 and functions in silencing at telomeres; has a C-terminal Sdc1 Dpy-30 Interaction (SDI) domain that mediates binding to Sdc1p; similar to trithorax-group protein ASH2L histone H3-K4 methylation|telomere maintenance|histone H3-K4 trimethylation|chromatin silencing at telomere histone methyltransferase activity (H3-K4 specific) Set1C/COMPASS complex
YER090W YER090W TRP2 hom Verified 1.60308123352855 0.0544583603267202 no 369 0.269890329957452 988 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p tryptophan biosynthetic process anthranilate synthase activity anthranilate synthase complex|cytoplasm
YLR087C YLR087C CSF1 hom Verified 1.60219136383921 0.0545566496100482 no 370 0.119853762557972 480 NA FF|FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies fermentation molecular_function mitochondrion
YCR102C_p YCR102C YCR102C hom Uncharacterized 1.59880606275217 0.0549318507576093 no 371 0.0548098728431643 312 NA FT OXIDATION-REDUCTION PROCESS Putative protein of unknown function, involved in copper metabolism; similar to C. carbonum toxD gene; member of the quinone oxidoreductase family response to copper ion molecular_function cellular_component
YPR021C YPR021C AGC1 hom Verified 1.59080807063343 0.0558263880514647 no 372 0.0602130510573931 311 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Mitochondrial amino acid transporter, acts both as a glutamate uniporter and as an aspartate-glutamate exchanger; involved in nitrogen metabolism and nitrogen compound biosynthesis L-glutamate transport|aspartate transport|cellular nitrogen compound biosynthetic process antiporter activity|L-aspartate transmembrane transporter activity|L-glutamate transmembrane transporter activity|uniporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YDL227C YDL227C HO hom Verified 1.58957924541358 0.0559648391956895 no 373 0.0303361283458713 171 NA FT NUCLEUS Site-specific endonuclease required for gene conversion at the MAT locus (homothallic switching) through the generation of a ds DNA break; expression restricted to mother cells in late G1 as controlled by Swi4p-Swi6p, Swi5p and Ash1p mating type switching|gene conversion at mating-type locus, DNA double-strand break formation endonuclease activity nucleus
YOR071C YOR071C NRT1 hom Verified 1.58920202265495 0.0560073949918926 no 374 0.0474734787431375 233 NA FT PLASMA MEMBRANE High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity thiamine transport|nicotinamide riboside transport nicotinamide riboside transporter activity integral to membrane|plasma membrane
YOL039W YOL039W RPP2A hom Verified 1.58804393675783 0.0561382021154025 no 375 0.0746808391961153 339 NA FT TRANSLATION RIBOSOME Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm translational elongation|cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YLR287C-A YLR287C-A RPS30A hom Verified 1.5857068322747 0.0564029142923733 no 376 0.0606877754388302 286 NA FT TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S30, no bacterial homolog; RPS30A has a paralog, RPS30B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic small ribosomal subunit|cytoplasmic stress granule
YNL190W_p YNL190W YNL190W hom Uncharacterized 1.58419186583809 0.0565750318908909 no 377 0.0646608838033782 310 NA Hydrophilin essential in dessication-rehydration process; cell wall protein; contains a putative GPI-attachment site cellular response to water deprivation molecular_function fungal-type cell wall
YMR038C YMR038C CCS1 hom Verified 1.58313298069043 0.0566955789354431 no 378 0.119727427351056 497 NA FF|FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS NUCLEUS|MITOCHONDRION Copper chaperone for superoxide dismutase Sod1p; involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation; protein abundance increases in response to DNA replication stress intracellular copper ion transport superoxide dismutase copper chaperone activity cytosol|mitochondrial inner membrane|nucleus
YML055W YML055W SPC2 hom Verified 1.58281248004389 0.0567321056695707 no 379 0.0726162487629411 318 NA FT PROTEIN LOCALIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC25 signal peptide processing|protein targeting to ER peptidase activity signal peptidase complex
YOR003W YOR003W YSP3 hom Verified 1.57989600767146 0.0570653418368524 no 380 0.0442415499945488 227 NA FT PROTEOLYSIS Putative precursor to the subtilisin-like protease III protein catabolic process peptidase activity cellular_component
YBR130C YBR130C SHE3 hom Verified 1.5791647597966 0.0571491353734744 no 381 0.0600337507773856 245 NA FT RNA LOCALIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH|CYTOSKELETON Protein that acts as an adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritance mating type switching|endoplasmic reticulum inheritance|intracellular mRNA localization mRNA binding actin cap|cytoplasm|cellular bud tip
YOR139C_d YOR139C YOR139C hom Dubious 1.57492658314306 0.0576366959176929 no 382 0.0760846571000098 313 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SFL1/YOR140W Unknown Unknown Unknown
YNL109W_d YNL109W YNL109W hom Dubious 1.57361636831567 0.0577880833951614 no 383 0.0602015839829447 267 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YNL108C Unknown Unknown Unknown
YCR102W-A_d YCR102W-A YCR102W-A hom Dubious 1.57138441197933 0.0580466922726341 no 384 0.0393712086717451 187 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR370C YLR370C ARC18 hom Verified 1.57125150517609 0.0580621203577838 no 385 0.125830527684882 543 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION MITOCHONDRION|CYTOSKELETON Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches mitochondrion inheritance|actin filament organization|establishment of mitochondrion localization molecular_function mitochondrion|Arp2/3 protein complex
YDR350C YDR350C ATP22 hom Verified 1.57104592480915 0.0580859908811202 no 386 0.0635658531772216 242 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Specific translational activator for the mitochondrial ATP6 mRNA, encoding a subunit of F1F0 ATP synthase; localized to the mitochondrial inner membrane proton-transporting ATP synthase complex biogenesis|positive regulation of mitochondrial translation translation regulator activity mitochondrial inner membrane
YEL018W YEL018W EAF5 hom Verified 1.56965716132185 0.058247446234201 no 387 0.069535620762962 280 NA FT CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS HISTONE ACETYLTRANSFERASE Esa1p-associated factor, non-essential subunit of the NuA4 acetyltransferase complex DNA repair molecular_function nucleus|NuA4 histone acetyltransferase complex
YLR085C YLR085C ARP6 hom Verified 1.56925547034689 0.0582942118387405 no 388 0.0950745314016331 469 NA FF|FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A chromatin remodeling|histone exchange nucleosome binding Swr1 complex|cytoplasm
YHR187W YHR187W IKI1 hom Verified 1.56498031026035 0.0587937630721652 no 389 0.0607538106126233 290 NA FT RNA PROCESSING NUCLEUS Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin tRNA modification tRNA binding|ATPase activity Elongator holoenzyme complex|nucleus|cytoplasm
YJR088C YJR088C EMC2 hom Verified 1.56473236032245 0.0588228387106461 no 390 0.038337153204319 231 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-2, fly CG17556, human TTC35 protein folding in endoplasmic reticulum molecular_function ER membrane protein complex|endoplasmic reticulum
YLR176C YLR176C RFX1 hom Verified 1.55704012347368 0.0597304797558571 no 391 0.053893046593649 262 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Major transcriptional repressor of DNA-damage-regulated genes, recruits repressors Tup1p and Cyc8p to their promoters; involved in DNA damage and replication checkpoint pathway; similar to a family of mammalian DNA binding RFX1-4 proteins negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding nucleus|cytoplasm
YDR220C_d YDR220C YDR220C hom Dubious 1.55626346447448 0.059822727744955 no 392 0.0448396640744089 213 NA Dubious open reading frame, null mutant exhibits synthetic phenotype with alpha-synuclein Unknown Unknown Unknown
YPR152C YPR152C URN1 hom Verified 1.55286789974447 0.0602273485259439 no 393 0.0557725358397531 228 NA FT RNA PROCESSING NUCLEUS Putative protein of unknown function containing WW and FF domains; overexpression causes accumulation of cells in G1 phase biological_process molecular_function nucleus
YLR178C YLR178C TFS1 hom Verified 1.55206836415777 0.0603229333340565 no 394 0.0351833266164655 163 NA FT SIGNALING|PROTEOLYSIS Protein that interacts with and inhibits carboxypeptidase Y and Ira2p; phosphatidylethanolamine-binding protein (PEBP) family member; targets to vacuolar membranes during stationary phase; acetylated by NatB N-terminal acetyltransferase; protein abundance increases in response to DNA replication stress regulation of Ras protein signal transduction|regulation of proteolysis lipid binding|peptidase inhibitor activity|phospholipid binding fungal-type vacuole lumen|fungal-type vacuole membrane|cytoplasm
YBR007C YBR007C DSF2 hom Verified 1.54676964574134 0.0609594010789839 no 395 0.0707134629700594 406 NA FF Deletion suppressor of mpt5 mutation; relocalizes from bud neck to cytoplasm upon DNA replication stress biological_process molecular_function cellular_component
YML001W YML001W YPT7 hom Verified 1.54623014855617 0.0610244974032632 no 396 0.0500675206630834 284 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|VACUOLAR TRANSPORT MITOCHONDRION Rab family GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion; interacts with the cargo selection/retromer complex for retrograde sorting; similar to mammalian Rab7 regulation of vacuole fusion, non-autophagic|piecemeal microautophagy of nucleus|vacuole inheritance|Golgi to vacuole transport|vesicle-mediated transport|endocytosis GTPase activity mitochondrial outer membrane|fungal-type vacuole
YKL053W_d YKL053W YKL053W hom Dubious 1.54480076728686 0.0611972308300507 no 397 0.0528522391577862 274 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF ASK1 Unknown Unknown Unknown
YJL137C YJL137C GLG2 hom Verified 1.54363626004501 0.0613382378173141 no 398 0.05558358353764 232 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG2 has a paralog, GLG1, that arose from the whole genome duplication glycogen biosynthetic process glycogenin glucosyltransferase activity cytoplasm
YJL045W YJL045W YJL045W hom Verified 1.54149510638605 0.0615981665120864 no 399 0.0591341862606917 278 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner cellular respiration succinate dehydrogenase (ubiquinone) activity mitochondrion
YPL193W YPL193W RSA1 hom Verified 1.54004610461629 0.0617745577942116 no 400 0.0919626152583147 384 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS NUCLEUS Protein involved in the assembly of 60S ribosomal subunits; functionally interacts with Dbp6p; functions in a late nucleoplasmic step of the assembly ribosomal large subunit assembly molecular_function nucleoplasm
YDL171C YDL171C GLT1 hom Verified 1.53937043660742 0.0618569435502069 no 401 0.0542968115193971 217 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION NAD(+)-dependent glutamate synthase (GOGAT), synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source glutamate biosynthetic process|ammonia assimilation cycle glutamate synthase (NADH) activity mitochondrion
YNR055C YNR055C HOL1 hom Verified 1.53880467930266 0.0619259935878902 no 402 0.0539463511746284 250 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION|PLASMA MEMBRANE Putative transporter in the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; mutations in membrane-spanning domains permit cation and histidinol uptake organic alcohol transport|cation transport alcohol transmembrane transporter activity|inorganic cation transmembrane transporter activity mitochondrion|integral to membrane|plasma membrane
YML042W YML042W CAT2 hom Verified 1.53330761903475 0.0626000391197646 no 403 0.0560162089854448 216 NA FT KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes carnitine metabolic process carnitine O-acetyltransferase activity mitochondrion|peroxisomal matrix|peroxisome
YIL167W YIL167W SDL1 hom pseudogene 1.52624052680206 0.0634749869748961 no 404 0.0649914814393554 297 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Open reading frame, unlikely to produce a functional protein in S288C; in closely related species and other S. cerevisiae strain backgrounds YIL167W and adjacent ORF, YIL168W, constitute a single ORF encoding L-serine dehydratase serine family amino acid metabolic process L-serine ammonia-lyase activity cellular_component
YJR084W YJR084W YJR084W hom Verified 1.52614884608702 0.0634863998077244 no 405 0.0452451819670563 211 NA FT RNA PROCESSING|SIGNALING NUCLEUS|CHROMOSOME Protein that forms a complex with Thp3p; may have a role in transcription elongation and/or mRNA splicing; identified as a COP9 signalosome component but phenotype and interactions suggest it may not be involved with the signalosome adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|mRNA splicing, via spliceosome molecular_function transcriptionally active chromatin
YLL048C YLL048C YBT1 hom Verified 1.52527225151349 0.0635956029422736 no 406 0.0568335968825904 259 NA FT NUCLEOTIDE METABOLISM Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates the release of lumenal Ca2+ stores; similar to mammalian bile transporters bile acid and bile salt transport bile acid-exporting ATPase activity integral to membrane|fungal-type vacuole
YDL056W YDL056W MBP1 hom Verified 1.52492230748299 0.063639238564767 no 407 0.0771889944240377 347 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE NUCLEUS Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes positive regulation of transcription involved in G1/S phase of mitotic cell cycle sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription MBF transcription complex|nucleus
YBR119W YBR119W MUD1 hom Verified 1.52437887263398 0.0637070473388992 no 408 0.0813618259517144 296 NA FT RNA PROCESSING NUCLEUS U1 snRNP A protein, homolog of human U1-A; involved in nuclear mRNA splicing mRNA splicing, via spliceosome U1 snRNA binding|RNA binding U1 snRNP|U2-type prespliceosome
YMR202W YMR202W ERG2 hom Verified 1.52387434643882 0.0637700514689957 no 409 0.187739336460527 778 NA FF|FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis ergosterol biosynthetic process C-8 sterol isomerase activity endoplasmic reticulum
YIR036C_p YIR036C IRC24 hom Uncharacterized 1.52312398101379 0.0638638451013255 no 410 0.0653943746776662 288 NA FT OXIDATION-REDUCTION PROCESS Putative benzil reductase;(GFP)-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS; sequence similarity with short-chain dehydrogenase/reductases; null mutant has increased spontaneous Rad52p foci biological_process molecular_function integral to membrane|cytoplasm
YGR239C YGR239C PEX21 hom Verified 1.52304150979158 0.063874160320076 no 411 0.0725776112517919 280 NA FT PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION Peroxin required for peroxisomal matrix protein targeting; acts on proteins containing the PTS2 targeting sequence; interacts with Pex7p; partially redundant with Pex18p; relative distribution to cytoplasmic foci increases upon DNA replication stress protein import into peroxisome matrix|positive regulation of protein binding protein binding cytosol|peroxisome
YEL017C-A YEL017C-A PMP2 hom Verified 1.52292586512799 0.063888626941951 no 412 0.0766818180332448 300 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog, PMP1, that arose from the whole genome duplication cation transport molecular_function membrane
YJL159W YJL159W HSP150 hom Verified 1.52256145520659 0.0639342296334324 no 413 0.0515437322984176 222 NA FT CELL WALL ORG/BIOGENESIS O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication fungal-type cell wall organization structural constituent of cell wall|ATPase activity fungal-type cell wall|extracellular region
YJL105W YJL105W SET4 hom Verified 1.52106859064156 0.0641213127865526 no 414 0.0693598874321548 361 NA FT CHROMATIN ORGANIZATION Protein of unknown function, contains a SET domain; SET4 has a paralog, SET3, that arose from the whole genome duplication biological_process molecular_function cellular_component
YHR014W YHR014W SPO13 hom Verified 1.51957750157998 0.0643085979796359 no 415 0.0404597255508776 192 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Meiosis-specific protein, involved in maintaining sister chromatid cohesion during meiosis I as well as promoting proper attachment of kinetochores to the spindle during meiosis I and meiosis II protein localization to chromosome, centromeric region|meiotic sister chromatid cohesion|positive regulation of sister chromatid cohesion molecular_function nucleus|condensed nuclear chromosome, centromeric region
YPL031C YPL031C PHO85 hom Verified 1.51878779030227 0.0644079600994179 no 416 0.0901759507455623 316 NA FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES A NUCLEUS Cyclin-dependent kinase, with ten cyclin partners; involved in regulating the cellular response to nutrient levels and environmental conditions and progression through the cell cycle regulation of transcription involved in G1/S phase of mitotic cell cycle|negative regulation of calcium-mediated signaling|regulation of protein stability|regulation of protein localization|protein phosphorylation|response to DNA damage stimulus|negative regulation of phosphate metabolic process|fungal-type cell wall organization|regulation of establishment or maintenance of cell polarity|negative regulation of glycogen biosynthetic process|negative regulation of transcription from RNA polymerase II promoter|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of macroautophagy|negative regulation of macroautophagy protein kinase activity|cyclin-dependent protein kinase activity cyclin-dependent protein kinase holoenzyme complex|nucleus
YAL042C-A_d YAL042C-A YAL042C-A hom Dubious 1.51849655998381 0.0644446330290196 no 417 0.0647644071094692 263 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF ERV46/YAL042W; YAL042C-A is a non-essential gene Unknown Unknown Unknown
YMR294W-A_d YMR294W-A YMR294W-A hom Dubious 1.51588717232955 0.0647739422248365 no 418 0.0736411255784752 296 NA Dubious open reading frame unlikely to encode a functional protein, substantially overlaps YMR295C; deletion causes sensitivity to unfolded protein response-inducing agents Unknown Unknown Unknown
YJL201W YJL201W ECM25 hom Verified 1.51452534291138 0.0649463255791041 no 419 0.0609130701211108 291 NA FT SIGNALING|CELL WALL ORG/BIOGENESIS Non-essential protein of unknown function; promoter contains a consensus binding sequence for factor Abf1p fungal-type cell wall organization|filamentous growth molecular_function cytoplasm
YDR276C YDR276C PMP3 hom Verified 1.51437954870335 0.0649648016135326 no 420 0.0689270342132112 327 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential regulation of membrane potential|cation transport molecular_function plasma membrane
YPR174C YPR174C YPR174C hom Verified 1.50958158863122 0.0655751111113464 no 421 0.0589809158526386 221 NA FT ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery; potential Cdc28p substrate; binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study; relative distribution to foci at the nuclear periphery increases upon DNA replication stress; YPR174C has a paralog, NBP1, that arose from the whole genome duplication biological_process molecular_function nuclear envelope|spindle pole body
YOR266W YOR266W PNT1 hom Verified 1.50815403440537 0.065757554233731 no 422 0.0431236610602132 170 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial integral inner membrane protein involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p; deletion mutant sensitive to the anti-Pneumocystis carinii drug pentamidine protein insertion into mitochondrial membrane from inner side molecular_function mitochondrion|integral to mitochondrial inner membrane
YHL042W_p YHL042W YHL042W hom Uncharacterized 1.5074302150087 0.0658502094135064 no 423 0.0579990773389371 237 NA Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins biological_process molecular_function cellular_component
YIL140W YIL140W AXL2 hom Verified 1.50682251181677 0.0659280788194174 no 424 0.0641600219048073 265 NA FT CELL CYCLE|CELL DIVISION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON Integral plasma membrane protein required for axial budding in haploid cells, localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate axial cellular bud site selection|cellular bud site selection molecular_function integral to plasma membrane|cellular bud neck|septin ring
YCL057W YCL057W PRD1 hom Verified 1.50557392727634 0.0660882928851644 no 425 0.06777001841525 303 NA FT PROTEOLYSIS MITOCHONDRION Zinc metalloendopeptidase; found in the cytoplasm and intermembrane space of mitochondria; with Cym1p, involved in degradation of mitochondrial proteins and of presequence peptides cleaved from imported proteins; protein abundance increases in response to DNA replication stress proteolysis metalloendopeptidase activity mitochondrion|cytoplasm|mitochondrial intermembrane space
YLR389C YLR389C STE23 hom Verified 1.50459295623673 0.066214379157287 no 426 0.0489315857126626 270 NA FT PROTEOLYSIS Metalloprotease involved, with homolog Axl1p, in N-terminal processing of pro-a-factor to the mature form; expressed in both haploids and diploids; member of the insulin-degrading enzyme family peptide pheromone maturation metallopeptidase activity|metalloendopeptidase activity extrinsic to membrane
YJR109C YJR109C CPA2 hom Verified 1.50225694463735 0.0665153817179729 no 427 0.0486407068257399 210 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Large subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor arginine biosynthetic process carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity carbamoyl-phosphate synthase complex
YDL006W YDL006W PTC1 hom Verified 1.5021256831285 0.06653232656335 no 428 0.136017151998688 529 NA FF|FT RNA PROCESSING|SIGNALING|MITOCHONDRION ORGANIZATION|PROTEIN PHOSPHORYLATION NUCLEUS Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p, inactivating osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing, mitochondrial inheritance, and sporulation mitochondrion inheritance|inactivation of MAPK activity involved in osmosensory signaling pathway|pheromone-dependent signal transduction involved in conjugation with cellular fusion|tRNA splicing, via endonucleolytic cleavage and ligation|protein dephosphorylation protein serine/threonine phosphatase activity nucleus|cytoplasm
YEL028W_d YEL028W YEL028W hom Dubious 1.50120318110607 0.0666515087194414 no 429 0.0867268219256269 354 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YBR217W YBR217W ATG12 hom Verified 1.49609485209723 0.0673144696164681 no 430 0.0773210748332591 318 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Conserved ubiquitin-like modifier involved in autophagy and the Cvt pathway; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg12p-Atg5p also forms a complex with Atg16p that is required for autophagosome formation C-terminal protein lipidation|piecemeal microautophagy of nucleus|mitochondrion degradation|CVT pathway|autophagic vacuole assembly Atg8 ligase activity|protein tag Atg12-Atg5-Atg16 complex|pre-autophagosomal structure
YMR295C YMR295C YMR295C hom Verified 1.49472088739801 0.0674936503526998 no 431 0.0619909113575524 251 NA FT SITE OF POLARIZED GROWTH Protein of unknown function that associates with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud; YMR295C is not an essential gene; protein abundance increases in response to DNA replication stress biological_process molecular_function ribosome|cellular bud|mating projection tip
YJL206C_p YJL206C YJL206C hom Uncharacterized 1.49395939486074 0.0675931163291174 no 432 0.0607045026658633 286 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Putative protein of unknown function; similar to transcriptional regulators from the Zn[2]-Cys[6] binuclear cluster protein family; mRNA is weakly cell cycle regulated, peaking in S phase; induced rapidly upon MMS treatment biological_process molecular_function cellular_component
YJL145W YJL145W SFH5 hom Verified 1.49296459150385 0.0677232278897753 no 433 0.0448887979910621 231 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Non-classical phosphatidylinositol transfer protein (PITP); exhibits PI- but not PC-transfer activity; localizes to the peripheral endoplasmic reticulum, cytosol and microsomes; similar to Sec14p; partially relocalizes to the plasma membrane upon DNA replication stress Golgi to plasma membrane protein transport|phosphatidylinositol metabolic process|Unknown|regulation of exocytosis|phospholipid transport phosphatidylinositol transporter activity|phosphatidylcholine transporter activity cell periphery|cytosol|plasma membrane|cortical endoplasmic reticulum
YHR155W YHR155W YSP1 hom Verified 1.49065037181458 0.0680266560267606 no 434 0.0819356945287972 376 NA FF|FT MITOCHONDRION Mitochondrial protein; potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone; YSP1 has a paralog, SIP3, that arose from the whole genome duplication biological_process molecular_function mitochondrion
YMR037C YMR037C MSN2 hom Verified 1.48955581929462 0.0681705330329883 no 435 0.0678710643886427 272 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|RESPONSE TO OXIDATIVE STRESS NUCLEUS Transcriptional activator; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression; MSN2 has a paralog, MSN4, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription from RNA polymerase II promoter in response to a hypotonic environment|positive regulation of transcription from RNA polymerase II promoter in response to alkalinity|positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation|positive regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation|positive regulation of transcription from RNA polymerase II promoter in response to acidity|chromatin remodeling|positive regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide|regulation of replicative cell aging by regulation of transcription from RNA polymerase II promoter in response to caloric restriction|positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance|positive regulation of transcription from RNA polymerase II promoter in response to increased salt|positive regulation of transcription from RNA polymerase II promoter in response to freezing|positive regulation of transcription from RNA polymerase II promoter in response to ethanol|age-dependent response to oxidative stress involved in chronological cell aging|replicative cell aging|positive regulation of transcription from RNA polymerase II promoter in response to hydrostatic pressure|cellular response to methylmercury|positive regulation of transcription from RNA polymerase II promoter in response to nitrosative stress|positive regulation of transcription from RNA polymerase II promoter in response to cold|positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding cytosol|nucleus
YKL211C YKL211C TRP3 hom Verified 1.48846053120171 0.0683147417337015 no 436 0.298412657199434 1079 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p tryptophan biosynthetic process indole-3-glycerol-phosphate synthase activity|anthranilate synthase activity anthranilate synthase complex|cytoplasm
YBL099W YBL099W ATP1 hom Verified 1.48692537153087 0.0685172612182403 no 437 0.0797519082089574 351 NA FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS MITOCHONDRION Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated ATP synthesis coupled proton transport hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism mitochondrial nucleoid|proton-transporting ATP synthase complex, catalytic core F(1)|mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase, catalytic core
YHR092C YHR092C HXT4 hom Verified 1.48158297569767 0.0692256458141211 no 438 0.0488528046766887 246 NA FT PLASMA MEMBRANE High-affinity glucose transporter; member of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose; HXT4 has a paralog, HXT7, that arose from the whole genome duplication hexose transport pentose transmembrane transporter activity|mannose transmembrane transporter activity|glucose transmembrane transporter activity|fructose transmembrane transporter activity integral to membrane|plasma membrane
YMR103C_d YMR103C YMR103C hom Dubious 1.47889789986022 0.0695838023705219 no 439 0.0720164070360506 280 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOR137C YOR137C SIA1 hom Verified 1.46648171199712 0.0712585499184874 no 440 0.0592069827789638 276 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Protein of unassigned function involved in activation of the Pma1p plasma membrane H+-ATPase by glucose proton transport molecular_function cellular_component
YJL147C_p YJL147C YJL147C hom Uncharacterized 1.46640865473302 0.0712684949621477 no 441 0.0579115393444712 266 NA FT MITOCHONDRION Mitochondrial protein of unknown function; homozygous diploid deletion strain has a sporulation defect characterized by elevated dityrosine in the soluble fraction; expression induced by calcium shortage; YJL147W is a non-essential gene biological_process molecular_function mitochondrion
YJR010W YJR010W MET3 hom Verified 1.4645055465055 0.0715279343547556 no 442 0.0680449772962432 281 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)|sulfur amino acid metabolic process sulfate adenylyltransferase (ATP) activity mitochondrion|cytoplasm
YDL241W_p YDL241W YDL241W hom Uncharacterized 1.46421144239179 0.0715680923840847 no 443 0.0578384748746471 229 NA Putative protein of unknown function; YDL241W is not an essential gene biological_process molecular_function cellular_component
YMR186W YMR186W HSC82 hom Verified 1.46238713649405 0.0718175762090965 no 444 0.072634796580851 284 NA FT PROTEIN COMPLEX ORG/BIOGENESIS MITOCHONDRION Cytoplasmic chaperone of the Hsp90 family; redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock; contains two acid-rich unstructured regions that promote the solubility of chaperone-substrate complexes; HSC82 has a paralog, HSP82, that arose from the whole genome duplication protein folding|proteasome assembly|protein refolding|telomere maintenance|'de novo' protein folding|box C/D snoRNP assembly|response to stress unfolded protein binding|ATPase activity, coupled|ATPase activity mitochondrion|plasma membrane|cytoplasm
YCR086W YCR086W CSM1 hom Verified 1.46123304986299 0.0719757479910724 no 445 0.0806566924366811 317 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CHROMOSOME SEGREGATION ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME KINETOCHORE Nucleolar protein that forms a complex with Lrs4p and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation meiotic chromosome segregation|rDNA condensation|protein localization to nucleolar rDNA repeats|homologous chromosome segregation molecular_function nuclear envelope|nucleolus|monopolin complex
YER150W YER150W SPI1 hom Verified 1.45990837163718 0.0721576290606458 no 446 0.0747504929000395 345 NA GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p response to acid molecular_function fungal-type cell wall
YKL142W YKL142W MRP8 hom Verified 1.45554624500978 0.0727590486734899 no 447 0.07382908404675 314 NA Protein of unknown function; undergoes sumoylation; transcription induced under cell wall stress; protein levels are reduced under anaerobic conditions; protein abundance increases in response to DNA replication stress; originally thought to be a mitochondrial ribosomal protein based on sequence analysis biological_process molecular_function cytoplasm
YNL269W YNL269W BSC4 hom Verified 1.45480599861032 0.0728614885261055 no 448 0.0639403080186754 286 NA Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough is increased upon depletion of Sup35p biological_process molecular_function cellular_component
YGR027C YGR027C RPS25A hom Verified 1.45266114822996 0.0731589295912902 no 449 0.0961995494038049 364 NA FT TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S25, no bacterial homolog; RPS25A has a paralog, RPS25B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic small ribosomal subunit
YDR371W_p YDR371W CTS2 hom Uncharacterized 1.45185136845661 0.0732714685772067 no 450 0.0611607133902296 259 NA FT CARBOHYDRATE METABOLISM Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect sporulation resulting in formation of a cellular spore molecular_function cytoplasm
YLL047W_d YLL047W YLL047W hom Dubious 1.45046064737456 0.0734650527330689 no 451 0.0832097597139427 324 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RNP1 Unknown Unknown Unknown
YFL010W-A YFL010W-A AUA1 hom Verified 1.44992179600426 0.07354016425532 no 452 0.0830172320941501 309 NA Protein required for the negative regulation by ammonia of Gap1p, which is a general amino acid permease amino acid transport molecular_function cellular_component
YCR087W_d YCR087W YCR087W hom Dubious 1.4491495253133 0.0736479149097888 no 453 0.0867662336693462 352 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YCR087C-A; YCR087W is not an essential gene Unknown Unknown Unknown
YJL049W_p YJL049W YJL049W hom Uncharacterized 1.44741247488222 0.0738907169535007 no 454 0.0437051833931067 189 NA FT PROTEIN LOCALIZATION Putative protein of unknown function; YJL049W is a non-essential gene biological_process molecular_function cellular_component
YKL134C YKL134C OCT1 hom Verified 1.44291315402807 0.0745224685970593 no 455 0.0778690453139363 340 NA FT PROTEIN LOCALIZATION|ION HOMEOSTASIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS MITOCHONDRION Mitochondrial intermediate peptidase, cleaves destabilizing N-terminal residues of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may contribute to mitochondrial iron homeostasis cellular iron ion homeostasis|protein processing involved in protein targeting to mitochondrion metalloendopeptidase activity mitochondrion
YOR085W YOR085W OST3 hom Verified 1.44145542055177 0.0747280314617631 no 456 0.0724392913095505 277 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins protein glycosylation|protein complex assembly|protein O-linked mannosylation|protein N-linked glycosylation dolichyl-diphosphooligosaccharide-protein glycotransferase activity oligosaccharyltransferase complex|integral to membrane
YDR485C YDR485C VPS72 hom Verified 1.43472178288593 0.0756831971902325 no 457 0.125921342756405 528 NA FF|FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting chromatin remodeling|histone exchange histone binding Swr1 complex|nucleus|cytoplasm
YBR230C YBR230C OM14 hom Verified 1.43368916574364 0.0758304926670739 no 458 0.0877673454362115 327 NA FT MITOCHONDRION Integral mitochondrial outer membrane protein; abundance is decreased in cells grown in glucose relative to other carbon sources; appears to contain 3 alpha-helical transmembrane segments; ORF encodes a 97-basepair intron biological_process molecular_function mitochondrion|integral to mitochondrial outer membrane
YMR129W YMR129W POM152 hom Verified 1.43012136176471 0.076341095082444 no 459 0.0405115969381399 168 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CYTOSKELETON ORGANIZATION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION NUCLEAR PORE Glycoprotein subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NUP210 nucleocytoplasmic transport|nuclear pore organization|protein import into nucleus|spindle pole body duplication associated with nuclear envelope protein anchor|structural constituent of nuclear pore mitochondrion|integral to membrane|nuclear pore transmembrane ring|nuclear envelope lumen|nuclear pore
YJL107C_p YJL107C YJL107C hom Uncharacterized 1.42565432286041 0.0769840737299099 no 460 0.0629043788867002 300 NA Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi biological_process molecular_function cellular_component
YIL009C-A YIL009C-A EST3 hom Verified 1.42564572663693 0.0769853150128161 no 461 0.0867935832174605 325 NA FT NUCLEUS|CHROMOSOME Component of the telomerase holoenzyme, involved in telomere replication telomere maintenance via telomerase ATP-dependent DNA/RNA helicase activity|GTPase activity|telomeric DNA binding chromosome, telomeric region|nucleus|telomerase holoenzyme complex
YLR327C YLR327C TMA10 hom Verified 1.42175473398194 0.0775487322934375 no 462 0.0770682722730254 318 NA FT NUCLEUS|MITOCHONDRION Protein of unknown function that associates with ribosomes; putative homolog of the F1F0-ATPase synthase regulator Stf2p; protein abundance increases in response to DNA replication stress biological_process molecular_function ribosome|nucleus|cytoplasm
YLR262C YLR262C YPT6 hom Verified 1.41887964887689 0.077967053221989 no 463 0.187372766004498 631 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING GOLGI APPARATUS|PLASMA MEMBRANE Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6 intracellular protein transport|retrograde transport, endosome to Golgi GTPase activity Golgi apparatus
YLR012C_p YLR012C YLR012C hom Uncharacterized 1.41684323202545 0.078264383392428 no 464 0.108508051362717 421 NA Putative protein of unknown function; YLR012C is not an essential gene biological_process molecular_function cellular_component
YDL112W YDL112W TRM3 hom Verified 1.41355045192026 0.0787469690206065 no 465 0.0886556367692229 326 NA FT RNA PROCESSING 2'-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs tRNA methylation tRNA (guanine) methyltransferase activity cytoplasm
YKL096W-A YKL096W-A CWP2 hom Verified 1.41326464465433 0.0787889626829246 no 466 0.0794293909335026 350 NA FT ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored fungal-type cell wall organization|regulation of pH structural constituent of cell wall fungal-type cell wall
YHR193C YHR193C EGD2 hom Verified 1.41320315182786 0.078798000041753 no 467 0.0774988207818599 323 NA FT PROTEIN LOCALIZATION NUCLEUS Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes 'de novo' cotranslational protein folding unfolded protein binding|phosphatidic acid binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4-phosphate binding nascent polypeptide-associated complex
YOL086W-A YOL086W-A MHF1 hom Verified 1.41099304129174 0.0791233329403795 no 468 0.0510447703223668 243 NA FT RESPONSE TO DNA DAMAGE Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM, a Fanconi anemia complementation group protein, to stabilize and remodel blocked replication forks and repair damaged DNA; mhf1 srs2 double mutants are MMS hypersensitive; ortholog of human centromere constitutive-associated network (CCAN) subunit CENP-S, also known as MHF1 response to DNA damage stimulus molecular_function cellular_component
YPR012W_d YPR012W YPR012W hom Dubious 1.41006062745735 0.0792608908888631 no 469 0.0732721484184917 319 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR012W is not an essential gene Unknown Unknown Unknown
YMR195W YMR195W ICY1 hom Verified 1.40893445801749 0.0794272746832719 no 470 0.0684680291135054 264 NA Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation biological_process molecular_function fungal-type vacuole membrane
YML058W YML058W SML1 hom Verified 1.40771147937517 0.0796082606340397 no 471 0.045583474822204 199 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION NUCLEUS Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase mitochondrion organization|response to DNA damage stimulus enzyme inhibitor activity nucleus|cytoplasm
YLR351C YLR351C NIT3 hom Verified 1.40652919761752 0.0797835203988298 no 472 0.0631156990896097 263 NA FT MITOCHONDRION Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member biological_process hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds mitochondrion|cytoplasm
YPL098C YPL098C MGR2 hom Verified 1.40443657798336 0.0800944425441918 no 473 0.0968395158052042 357 NA FT MITOCHONDRION Subunit of the TIM23 translocase complex; acts to couple Tim21p with the core Tim23 translocase; absolutely required for mitochondrial import of presequence-containing proteins at elevated temperature; required for viability of cells lacking the mitochondrial genome (petite-negative phenotype) protein import into mitochondrial matrix molecular_function mitochondrial inner membrane presequence translocase complex
YGR161C_p YGR161C RTS3 hom Uncharacterized 1.40291133101737 0.0803216407742124 no 474 0.0781843701748219 314 NA FT NUCLEUS Putative component of the protein phosphatase type 2A complex biological_process molecular_function nucleus|cytoplasm
YDR426C_d YDR426C YDR426C hom Dubious 1.39928358474832 0.0808639800759753 no 475 0.0491258076840488 211 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SNX41 Unknown Unknown Unknown
YIL014C-A_p YIL014C-A YIL014C-A hom Uncharacterized 1.39522298255031 0.0814743042921832 no 476 0.096077006053886 381 NA Putative protein of unknown function biological_process molecular_function cellular_component
YGR196C YGR196C FYV8 hom Verified 1.39354643163725 0.0817273072439721 no 477 0.0814821591243809 337 NA Protein of unknown function, required for survival upon exposure to K1 killer toxin biological_process molecular_function cytoplasm
YPL259C YPL259C APM1 hom Verified 1.39321460917203 0.081777451647642 no 478 0.110183097798798 437 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Mu1-like medium subunit of the clathrin-associated protein complex (AP-1); binds clathrin; involved in clathrin-dependent Golgi protein sorting Golgi to vacuole transport|vesicle-mediated transport clathrin binding AP-1 adaptor complex
YBL091C-A YBL091C-A SCS22 hom Verified 1.39171520738924 0.0820043276879588 no 479 0.0806045708926089 357 NA FT LIPID METABOLISM Protein involved in regulation of phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; similar to D. melanogaster inturned protein; SCS22 has a paralog, SCS2, that arose from the whole genome duplication phospholipid biosynthetic process|chromatin silencing at telomere molecular_function cellular_component
YNL197C YNL197C WHI3 hom Verified 1.39010638331782 0.0822482876075839 no 480 0.0862788479629823 398 NA FT PROTEIN LOCALIZATION|CELL CYCLE RNA binding protein that sequesters CLN3 mRNA in cytoplasmic foci;; Tpk1 (PKA) mediated phosphorylation of Whi3 affects G1/S transition by modulating Cln3 transcription; cytoplasmic retention factor for Cdc28p and associated cyclins; regulates cell fate and dose-dependently regulates the critical cell size required for passage through Start; WHI3 has a paralog, WHI4, that arose from the whole genome duplication pseudohyphal growth|invasive growth in response to glucose limitation|regulation of cell size|cytoplasmic sequestering of protein RNA binding cytoplasm
YGL107C YGL107C RMD9 hom Verified 1.38892290359019 0.0824280975375882 no 481 0.0938045272002808 337 NA FT TRANSLATION|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes translational initiation|regulation of mRNA stability|aerobic respiration molecular_function extrinsic to mitochondrial inner membrane|mitochondrion
YOR354C YOR354C MSC6 hom Verified 1.38736504661887 0.0826652388295677 no 482 0.0921757341646362 345 NA FT CELL CYCLE MITOCHONDRION Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies reciprocal meiotic recombination molecular_function mitochondrion
YKR061W YKR061W KTR2 hom Verified 1.38091305604555 0.0836528475395829 no 483 0.0684123661235001 263 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Mannosyltransferase involved in N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR2 has a paralog, YUR1, that arose from the whole genome duplication cell wall mannoprotein biosynthetic process|protein N-linked glycosylation mannosyltransferase activity Golgi apparatus
YDR488C YDR488C PAC11 hom Verified 1.36811935614618 0.0856373594315364 no 484 0.0591489690815859 242 NA FT CYTOSKELETON Dynein intermediate chain, acts in the cytoplasmic dynein pathway, forms cortical cytoplasmic microtubule capture site with Num1p; null mutant is defective in nuclear migration, essential in the absence of CIN8 nuclear migration along microtubule|microtubule-based process plus-end-directed microtubule motor activity|microtubule motor activity cytoplasmic dynein complex|cytoplasmic microtubule
YJL157C YJL157C FAR1 hom Verified 1.36689883611452 0.0858285084373722 no 485 0.0506303222926822 244 NA FT PROTEIN LOCALIZATION|CELL CYCLE|SIGNALING|CELL DIVISION NUCLEUS|SITE OF POLARIZED GROWTH Cyclin-dependent kinase inhibitor; mediates cell cycle arrest in response to pheromone; also forms a complex with Cdc24p, Ste4p, and Ste18p that may specify the direction of polarized growth during mating; potential Cdc28p substrate; relocalizes from nucleus to cytoplasm upon DNA replication stress maintenance of protein location in nucleus|pheromone-dependent signal transduction involved in conjugation with cellular fusion|cell cycle arrest in response to pheromone cyclin-dependent protein kinase inhibitor activity nucleus|mating projection tip|membrane|cytoplasm
YNL090W YNL090W RHO2 hom Verified 1.36364924892507 0.0863389920262705 no 486 0.0893708849196216 387 NA FT SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION PLASMA MEMBRANE Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, involved in the establishment of cell polarity and in microtubule assembly microtubule-based process|fungal-type cell wall organization|actin filament organization|establishment of cell polarity|small GTPase mediated signal transduction GTPase activity membrane
YOR054C YOR054C VHS3 hom Verified 1.36312866218157 0.0864209825177337 no 487 0.0951668143378304 338 NA FT CELL CYCLE|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|COFACTOR METABOLISM Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis coenzyme A biosynthetic process|cellular monovalent inorganic cation homeostasis phosphopantothenoylcysteine decarboxylase activity|protein phosphatase inhibitor activity phosphopantothenoylcysteine decarboxylase complex
YDR272W YDR272W GLO2 hom Verified 1.36307069534736 0.0864301156811706 no 488 0.0838606506259387 340 NA FT KETONE METABOLISM|CARBOHYDRATE METABOLISM Cytoplasmic glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate cellular carbohydrate metabolic process|methylglyoxal catabolic process to D-lactate hydroxyacylglutathione hydrolase activity cytoplasm
YER091C-A_d YER091C-A YER091C-A hom Dubious 1.3623049348352 0.0865508354525422 no 489 0.100385520216456 389 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR462W YDR462W MRPL28 hom Verified 1.36174373564937 0.0866393867689664 no 490 0.0924846107492783 410 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YMR130W_p YMR130W YMR130W hom Uncharacterized 1.36171215943964 0.0866443711735058 no 491 0.0535132045988741 211 NA Putative protein of unknown function; YMR130W is not an essential gene biological_process molecular_function cellular_component
YPL047W YPL047W SGF11 hom Verified 1.36071616811437 0.0868017015731148 no 492 0.0839453506223818 372 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS HISTONE ACETYLTRANSFERASE Integral subunit of SAGA histone acetyltransferase complex, regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation histone deubiquitination|regulation of transcription from RNA polymerase II promoter enzyme activator activity DUBm complex|nucleus|SAGA complex
YKL208W YKL208W CBT1 hom Verified 1.36056245072082 0.0868260023327896 no 493 0.0855892921852369 352 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS MITOCHONDRION Protein involved in 5' end processing of mitochondrial COB, 15S_rRNA, and RPM1 transcripts; may also have a role in 3' end processing of the COB pre-mRNA; displays genetic interaction with cell cycle-regulated kinase Dbf2p cytochrome complex assembly|mRNA processing|mRNA stabilization molecular_function mitochondrion
YPR063C_p YPR063C YPR063C hom Uncharacterized 1.3604130930458 0.0868496187452067 no 494 0.0978083822339929 385 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM ER-localized protein of unknown function biological_process molecular_function endoplasmic reticulum
YLL015W YLL015W BPT1 hom Verified 1.35896780465442 0.0870783954962484 no 495 0.071042872664425 241 NA FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS ABC type transmembrane transporter of MRP/CFTR family, found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p cadmium ion transport|bilirubin transport bilirubin transmembrane transporter activity|cadmium ion transmembrane transporter activity fungal-type vacuole membrane|integral to membrane
YDR326C YDR326C YSP2 hom Verified 1.35893501507747 0.0870835910213033 no 496 0.092942330572093 411 NA FT MITOCHONDRION Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification; YSP2 has a paralog, YHR080C, that arose from the whole genome duplication apoptotic process molecular_function mitochondrion
YCR075C YCR075C ERS1 hom Verified 1.35889514618037 0.0870899085800992 no 497 0.0756127184175173 350 NA Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains L-cystine transport|transmembrane transport L-cystine transmembrane transporter activity endosome|integral to membrane|fungal-type vacuole
YIL139C YIL139C REV7 hom Verified 1.35868660122836 0.0871229598425668 no 498 0.0777608920227224 299 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION|CHROMOSOME Accessory subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair error-prone translesion synthesis|error-free translesion synthesis DNA-directed DNA polymerase activity nuclear chromatin|mitochondrion|zeta DNA polymerase complex
YNR056C YNR056C BIO5 hom Verified 1.35773031386673 0.0872746370833447 no 499 0.084489420334277 342 NA FT KETONE METABOLISM|COFACTOR METABOLISM PLASMA MEMBRANE Putative transmembrane protein involved in the biotin biosynthesis pathway; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis biotin biosynthetic process|vitamin transport transmembrane transporter activity integral to membrane|plasma membrane
YOR031W YOR031W CRS5 hom Verified 1.3560896424249 0.0875353239831315 no 500 0.0767873843819202 312 NA Copper-binding metallothionein, required for wild-type copper resistance response to metal ion copper ion binding cytoplasm
YHL039W YHL039W EFM1 hom Verified 1.35351542616712 0.0879455126204336 no 501 0.0905559881013924 409 NA Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm peptidyl-lysine monomethylation protein-lysine N-methyltransferase activity cytoplasm
YIL153W YIL153W RRD1 hom Verified 1.35273316492231 0.0880704456169595 no 502 0.1078175240367 438 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RESPONSE TO DNA DAMAGE|CYTOSKELETON ORGANIZATION NUCLEUS|CHROMOSOME Peptidyl-prolyl cis/trans-isomerase; activator of the phosphotyrosyl phosphatase activity of PP2A; involved in G1 phase progression, microtubule dynamics, bud morphogenesis and DNA repair; required for rapid reduction of Sgs1p levels in response to rapamycin; subunit of the Tap42p-Sit4p-Rrd1p complex; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress DNA repair|mitotic spindle organization in nucleus|G1/S transition of mitotic cell cycle|response to osmotic stress|regulation of transcription from RNA polymerase II promoter in response to stress peptidyl-prolyl cis-trans isomerase activity|protein phosphatase type 2A regulator activity nuclear chromatin|nucleus|cytoplasm
YDR055W YDR055W PST1 hom Verified 1.35231948649862 0.0881365666343226 no 503 0.0887611536429409 316 NA FT CELL WALL ORG/BIOGENESIS PLASMA MEMBRANE Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1 fungal-type cell wall organization molecular_function fungal-type cell wall|plasma membrane
YJR100C YJR100C AIM25 hom Verified 1.34506864990129 0.0893015330641338 no 504 0.0746014720663636 275 NA FT MITOCHONDRION Putative protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to murine NOR1; null mutant is viable and displays elevated frequency of mitochondrial genome loss biological_process molecular_function mitochondrion
YPL079W YPL079W RPL21B hom Verified 1.34472877030807 0.0893564200691537 no 505 0.0818992318686384 348 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L21B; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21B has a paralog, RPL21A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YGR197C YGR197C SNG1 hom Verified 1.34464295925032 0.0893702816258883 no 506 0.0747279269910593 295 NA FT PLASMA MEMBRANE Protein involved in resistance to nitrosoguanidine (MNNG) and 6-azauracil (6-AU); expression is regulated by transcription factors involved in multidrug resistance nucleobase-containing compound transport molecular_function integral to membrane|plasma membrane
YER032W YER032W FIR1 hom Verified 1.34459294537504 0.0893783613943828 no 507 0.105948326732548 387 NA FT RNA PROCESSING SITE OF POLARIZED GROWTH Protein involved in 3' mRNA processing, interacts with Ref2p; potential Cdc28p substrate mRNA polyadenylation|RNA polyadenylation molecular_function cellular bud neck
YJL131C YJL131C AIM23 hom Verified 1.34195027894967 0.0898060588579759 no 508 0.0771578741275788 287 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial translation initiation factor 3 (IF3, mIF3); evolutionarily conserved; binds to E. coli ribosomes in vitro; null mutant displays severe respiratory growth defect and elevated frequency of mitochondrial genome loss positive regulation of mitochondrial translational initiation ribosome binding|translation initiation factor activity mitochondrion
YAL015C YAL015C NTG1 hom Verified 1.33972124278533 0.0901679943224065 no 509 0.0773541090115132 287 NA FT RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION|RESPONSE TO OXIDATIVE STRESS NUCLEUS|MITOCHONDRION DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication DNA repair|cellular response to oxidative stress|base-excision repair|base-excision repair, AP site formation|positive regulation of mitochondrial DNA replication oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity|oxidized purine nucleobase lesion DNA N-glycosylase activity|DNA-(apurinic or apyrimidinic site) lyase activity mitochondrion|nucleus
YBR178W_d YBR178W YBR178W hom Dubious 1.33755802810974 0.0905202771196993 no 510 0.0973315640731312 363 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR177C Unknown Unknown Unknown
YOR001W YOR001W RRP6 hom Verified 1.33735382572228 0.0905535844961463 no 511 0.0489588905861204 243 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|RNA LOCALIZATION NUCLEUS Nuclear exosome exonuclease component; has 3'-5' exonuclease activity; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10); mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent snRNA catabolic process|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|histone mRNA catabolic process|nuclear polyadenylation-dependent antisense transcript catabolic process|U1 snRNA 3'-end processing|polyadenylation-dependent snoRNA 3'-end processing|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|U5 snRNA 3'-end processing|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear retention of pre-mRNA at the site of transcription|nuclear polyadenylation-dependent mRNA catabolic process|U4 snRNA 3'-end processing|nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription 3'-5'-exoribonuclease activity nucleolus|nucleus|nuclear exosome (RNase complex)
YGL218W_d YGL218W YGL218W hom Dubious 1.3357183213728 0.0908206793151952 no 512 0.129458176204346 444 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 93% of ORF overlaps the verified gene MDM34; deletion in cyr1 mutant results in loss of stress resistance Unknown Unknown Unknown
YNL072W YNL072W RNH201 hom Verified 1.33253474770285 0.0913422655559971 no 513 0.18908179282473 650 NA FT NUCLEUS Ribonuclease H2 catalytic subunit, removes RNA primers during Okazaki fragment synthesis and errant ribonucleotides misincorporated during DNA replication; homolog of RNAse HI; related to human AGS4 which causes Aicardi-Goutieres syndrome DNA replication, removal of RNA primer ribonuclease H activity ribonuclease H2 complex|nucleus
YKR067W YKR067W GPT2 hom Verified 1.33013644415307 0.091736659918814 no 514 0.110195014236859 453 NA FT LIPID METABOLISM ENDOPLASMIC RETICULUM Glycerol-3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis; the most conserved motifs and functionally relevant residues are oriented towards the ER lumen phospholipid biosynthetic process glycerol-3-phosphate O-acyltransferase activity|glycerone-phosphate O-acyltransferase activity integral to membrane|lipid particle|endoplasmic reticulum|cytoplasm
YDR418W YDR418W RPL12B hom Verified 1.329753934319 0.0917996790740308 no 515 0.0869409100822757 382 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal 60S subunit protein L12B; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12B has a paralog, RPL12A, that arose from the whole genome duplication cytoplasmic translation|ribosomal large subunit assembly structural constituent of ribosome cytosolic large ribosomal subunit
YOL155C YOL155C HPF1 hom Verified 1.32684337554297 0.0922802493334706 no 516 0.100734805376397 435 NA FT CELL WALL ORG/BIOGENESIS Haze-protective mannoprotein that reduces the particle size of aggregated proteins in white wines fungal-type cell wall organization glucosidase activity fungal-type cell wall|extracellular region
YKR075C_p YKR075C YKR075C hom Uncharacterized 1.3239584208631 0.0927584270372643 no 517 0.0998495369669543 408 NA FT NUCLEUS Protein of unknown function; similar to YOR062Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS biological_process molecular_function nucleus|cytoplasm
YJR094C YJR094C IME1 hom Verified 1.32363016511552 0.0928129509203756 no 518 0.0619060620798261 238 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE NUCLEUS Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p pseudohyphal growth|regulation of transcription from RNA polymerase II promoter|regulation of meiosis protein binding transcription factor activity nucleus
YMR031C YMR031C EIS1 hom Verified 1.32355101965184 0.092826100672526 no 519 0.101666064471571 346 NA FT PROTEIN COMPLEX ORG/BIOGENESIS MITOCHONDRION|PLASMA MEMBRANE Component of the eisosome required for proper eisosome assembly; similarity to Ykl050cp and Uso1p; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress eisosome assembly molecular_function eisosome|mitochondrion|membrane raft|cytoplasm
YPR160W YPR160W GPH1 hom Verified 1.3176027838412 0.0938183266080661 no 520 0.0699636614261487 288 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway glycogen catabolic process glycogen phosphorylase activity cytoplasm
YMR306C-A_d YMR306C-A YMR306C-A hom Dubious 1.31658941635732 0.0939881441598872 no 521 0.0785672328605335 347 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLL026W YLL026W HSP104 hom Verified 1.31615848800631 0.0940604267369365 no 522 0.0962476001983643 338 NA FT PROTEIN LOCALIZATION|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS NUCLEUS Disaggregase; heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress trehalose metabolism in response to heat stress|protein folding in endoplasmic reticulum|protein unfolding|chaperone cofactor-dependent protein refolding|inheritance of oxidatively modified proteins involved in replicative cell aging|cellular heat acclimation ADP binding|unfolded protein binding|ATPase activity, coupled|chaperone binding|ATP binding TRC complex|nucleus|cytoplasm
YER065C YER065C ICL1 hom Verified 1.31545022627369 0.0941793174428249 no 523 0.0714730430471106 284 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose glyoxylate cycle isocitrate lyase activity cellular_component
YKL191W YKL191W DPH2 hom Verified 1.31111202712754 0.0949099589855916 no 524 0.0798271105754189 330 NA Protein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11p peptidyl-diphthamide biosynthetic process from peptidyl-histidine molecular_function cytoplasm
YOL031C YOL031C SIL1 hom Verified 1.3110970331095 0.0949124915065837 no 525 0.0837708676018815 392 NA FT PROTEIN LOCALIZATION ENDOPLASMIC RETICULUM Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, required for protein translocation into the ER; homolog of Yarrowia lipolytica SLS1; GrpE-like protein SRP-dependent cotranslational protein targeting to membrane, translocation adenyl-nucleotide exchange factor activity endoplasmic reticulum
YER184C_p YER184C YER184C hom Uncharacterized 1.30915552553665 0.0952408369367967 no 526 0.102643455868483 401 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Putative zinc cluster protein; deletion confers sensitivity to Calcufluor white, and prevents growth on glycerol or lactate as sole carbon source biological_process sequence-specific DNA binding cellular_component
YOR172W YOR172W YRM1 hom Verified 1.30850515488452 0.0953510136415836 no 527 0.0943056776541298 374 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrr1p, acting on an overlapping set of target genes regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding|nucleic acid binding transcription factor activity nucleus|cytoplasm
YBL096C_d YBL096C YBL096C hom Dubious 1.30583566162966 0.0958042249042651 no 528 0.07898838912488 339 NA Non-essential protein of unknown function Unknown Unknown Unknown
YKL039W YKL039W PTM1 hom Verified 1.30487532392296 0.0959676524935104 no 529 0.0875544326566893 344 NA FT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Protein of unknown function; copurifies with late Golgi vesicles containing the v-SNARE Tlg2p; PTM1 has a paralog, YHL017W, that arose from the whole genome duplication biological_process molecular_function integral to membrane
YGL006W YGL006W PMC1 hom Verified 1.30478679574857 0.0959827282854679 no 530 0.0833605567555197 316 NA FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions; prevents growth inhibition by activation of calcineurin in the presence of elevated concentrations of calcium; similar to mammalian PMCA1a cellular calcium ion homeostasis|calcium ion transport|transmembrane transport calcium-transporting ATPase activity fungal-type vacuole membrane|integral to membrane
YGR020C YGR020C VMA7 hom Verified 1.30397939751477 0.096120303512798 no 531 0.147526156304488 552 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane vacuolar acidification proton-transporting ATPase activity, rotational mechanism fungal-type vacuole membrane|vacuolar proton-transporting V-type ATPase, V1 domain|integral to membrane
YBR041W YBR041W FAT1 hom Verified 1.30320070371562 0.0962531249799084 no 532 0.125814827034239 434 NA FT KETONE METABOLISM|LIPID METABOLISM ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Very long chain fatty acyl-CoA synthetase and long chain fatty acid transporter; activates imported fatty acids with a preference for very long lengths (C20-C26); has a separate function in the transport of long chain fatty acids very long-chain fatty acid metabolic process|long-chain fatty acid transport very long-chain fatty acid-CoA ligase activity|long-chain fatty acid transporter activity intrinsic to internal side of plasma membrane|integral to membrane|endoplasmic reticulum|lipid particle|peroxisome
YOR235W_d YOR235W IRC13 hom Dubious 1.30141726668635 0.0965578332749798 no 533 0.135426489792337 493 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays increased levels of spontaneous Rad52 foci Unknown Unknown Unknown
YCR095W-A_p YCR095W-A YCR095W-A hom Uncharacterized 1.29915563494049 0.0969452616643574 no 534 0.0888522719960088 346 NA Putative protein of unknown function biological_process molecular_function cellular_component
YML007C-A_p YML007C-A YML007C-A hom Uncharacterized 1.2981550695219 0.0971170269920405 no 535 0.119182103370527 548 NA FF|FT MITOCHONDRION Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria biological_process molecular_function mitochondrion
YNL129W YNL129W NRK1 hom Verified 1.296842930289 0.0973426180258227 no 536 0.0743187539869683 261 NA FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM Nicotinamide riboside kinase, catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis nicotinamide riboside metabolic process|NAD biosynthesis via nicotinamide riboside salvage pathway|NAD biosynthetic process nicotinic acid riboside kinase activity|ribosylnicotinamide kinase activity cytoplasm
YGL084C YGL084C GUP1 hom Verified 1.2963510355803 0.0974272865817726 no 537 0.203475321253093 742 NA FF|FT LIPID METABOLISM|CARBOHYDRATE METABOLISM ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; proposed to be involved in glycerol transport GPI anchor biosynthetic process|glycerol transport|glycerol catabolic process O-acyltransferase activity integral to membrane|endoplasmic reticulum|plasma membrane|membrane
YNL076W YNL076W MKS1 hom Verified 1.29476416553595 0.0977007986153517 no 538 0.0856530048498353 327 NA FT TRANSCRIPTION FROM RNA POL II|SIGNALING NUCLEUS Pleiotropic negative transcriptional regulator involved in Ras-CAMP and lysine biosynthetic pathways and nitrogen regulation; involved in retrograde (RTG) mitochondria-to-nucleus signaling regulation of nitrogen utilization|negative regulation of transcription from RNA polymerase II promoter|Unknown|mitochondria-nucleus signaling pathway molecular_function cytoplasm
YMR135W-A_d YMR135W-A YMR135W-A hom Dubious 1.29452059810659 0.0977428295481144 no 539 0.0688829072040346 249 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YMR192W YMR192W GYL1 hom Verified 1.29290104978191 0.0980226421974927 no 540 0.0803600511954457 296 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM MITOCHONDRION|GOLGI APPARATUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Putative GTPase activating protein (GAP) with a role in exocytosis; stimulates Gyp5p GAP activity on Ypt1p, colocalizes with Gyp5p at sites of polarized growth; interacts with Gyp5p, Rvs161p, and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; increases in abundance and relocalizes from bud neck to cytoplasm upon DNA replication stress ER to Golgi vesicle-mediated transport|regulation of exocytosis protein binding mitochondrion|incipient cellular bud site|cellular bud|cellular bud neck|cellular bud tip|cytoplasm|Golgi-associated vesicle|plasma membrane
YGL012W YGL012W ERG4 hom Verified 1.2892852801773 0.0986494632227396 no 541 0.218415885726189 804 NA FF|FT LIPID METABOLISM|OXIDATION-REDUCTION PROCESS ENDOPLASMIC RETICULUM C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol ergosterol biosynthetic process delta24(24-1) sterol reductase activity integral to membrane|endoplasmic reticulum
YJR048W YJR048W CYC1 hom Verified 1.28849885152784 0.0987861841887571 no 542 0.0713294798479366 321 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; CYC1 has a paralog, CYC7, that arose from the whole genome duplication mitochondrial electron transport, cytochrome c to oxygen|mitochondrial electron transport, ubiquinol to cytochrome c electron carrier activity mitochondrion|mitochondrial intermembrane space
YKL215C YKL215C OXP1 hom Verified 1.28584675678667 0.0992482742549248 no 543 0.0783506421353434 276 NA FT KETONE METABOLISM|AMINO ACID METABOLISM 5-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress glutathione metabolic process 5-oxoprolinase (ATP-hydrolyzing) activity cytoplasm
YJR150C YJR150C DAN1 hom Verified 1.28272792801683 0.0997937059363302 no 544 0.0768269723277214 326 NA Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth sterol transport molecular_function fungal-type cell wall
YLL006W-A_p YLL006W-A YLL006W-A hom Uncharacterized 1.28002287935363 0.100268544737812 no 545 0.0727644047933412 293 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YMR225C YMR225C MRPL44 hom Verified 1.27966952403082 0.100330693596314 no 546 0.0963255767368101 398 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YMR008C YMR008C PLB1 hom Verified 1.27752590858915 0.100708319740432 no 547 0.0945386657734625 327 NA FT LIPID METABOLISM PLASMA MEMBRANE Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol glycerophospholipid metabolic process lysophospholipase activity periplasmic space|plasma membrane
YDR387C_p YDR387C YDR387C hom Uncharacterized 1.27253962977806 0.101590726400041 no 548 0.074788435844539 291 NA Putative transporter, member of the sugar porter family; YDR387C is not an essential gene transport|transmembrane transport substrate-specific transmembrane transporter activity integral to membrane|membrane
YMR286W YMR286W MRPL33 hom Verified 1.27107738821573 0.101850559352504 no 549 0.104569770713599 429 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YDR124W_p YDR124W YDR124W hom Uncharacterized 1.27081108112469 0.101897932803455 no 550 0.090307316726254 340 NA Putative protein of unknown function; non-essential gene; expression is strongly induced by alpha factor biological_process molecular_function cellular_component
YBR299W YBR299W MAL32 hom Verified 1.26947667372864 0.102135552469071 no 551 0.107155595036403 409 NA FT CARBOHYDRATE METABOLISM Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose sucrose catabolic process|maltose catabolic process sucrose alpha-glucosidase activity|alpha-glucosidase activity|maltose alpha-glucosidase activity plasma membrane
YER005W YER005W YND1 hom Verified 1.26877837773568 0.102260059503092 no 552 0.102036748293366 409 NA FT LIPID METABOLISM|CARBOHYDRATE METABOLISM GOLGI APPARATUS Apyrase with wide substrate specificity, helps prevent inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates that inhibit glycotransferases; partially redundant with Gda1p; mediates adenovirus E4orf4-induced toxicity protein glycosylation nucleoside-triphosphatase activity|nucleoside-diphosphatase activity COPI-coated vesicle|Golgi apparatus|membrane|Golgi membrane
YPR172W_p YPR172W YPR172W hom Uncharacterized 1.26829640580342 0.102346060062077 no 553 0.0960157871976117 447 NA FT OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM NUCLEUS Putative pyridoxal 5'-phosphate synthase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; YPR172W has a paralog, YLR456W, that arose from the whole genome duplication biological_process molecular_function nucleus|cytoplasm
YNL134C YNL134C YNL134C hom Verified 1.26648071466877 0.102670514829049 no 554 0.0792078234534865 286 NA FT OXIDATION-REDUCTION PROCESS NUCLEUS Protein of unknown function; similar to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress biological_process alcohol dehydrogenase (NADP+) activity nucleus|cytoplasm
YGR181W YGR181W TIM13 hom Verified 1.26620926697992 0.102719085316724 no 555 0.070427335403047 309 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial intermembrane space protein, forms a complex with Tim8p that delivers a subset of hydrophobic proteins to the TIM22 complex for insertion into the inner membrane protein import into mitochondrial inner membrane protein transporter activity mitochondrion|integral to membrane|mitochondrial intermembrane space protein transporter complex|mitochondrial intermembrane space
YNL336W YNL336W COS1 hom Verified 1.26401092832786 0.103113052259438 no 556 0.107047782982837 430 NA Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins biological_process molecular_function integral to membrane|fungal-type vacuole
YBR290W YBR290W BSD2 hom Verified 1.26340770715817 0.103221347885688 no 557 0.110033378451815 463 NA FT PROTEIN LOCALIZATION|ION HOMEOSTASIS|PROTEOLYSIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT ENDOPLASMIC RETICULUM Heavy metal ion homeostasis protein, facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded, controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification metal ion transport|ubiquitin-dependent protein catabolic process|protein targeting to vacuole protein binding fungal-type vacuole membrane|integral to membrane|endoplasmic reticulum
YMR142C YMR142C RPL13B hom Verified 1.26168191494407 0.103531633533929 no 558 0.116098234109574 447 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L13B; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13B has a paralog, RPL13A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YHR079C-A YHR079C-A SAE3 hom Verified 1.26153622568501 0.103557858418036 no 559 0.114511191730942 387 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Mei5p; proposed to be an assembly factor for Dmc1p double-strand break repair|reciprocal meiotic recombination|meiotic DNA recombinase assembly molecular_function condensed nuclear chromosome
YNL333W YNL333W SNZ2 hom Verified 1.25823888343027 0.104152688300839 no 560 0.103954578475848 391 NA FT COFACTOR METABOLISM Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO2; interacts with Thi11p pyridoxine metabolic process|thiamine biosynthetic process protein binding cellular_component
YJL121C YJL121C RPE1 hom Verified 1.257505263885 0.104285367073881 no 561 0.128524720375407 476 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress pentose-phosphate shunt ribulose-phosphate 3-epimerase activity cytosol
YJL044C YJL044C GYP6 hom Verified 1.25308005727857 0.105088286487116 no 562 0.107275539572171 387 NA FT PROTEIN LOCALIZATION|SIGNALING|NUCLEOTIDE METABOLISM GTPase-activating protein (GAP) for the yeast Rab family member, Ypt6p; involved in vesicle mediated protein transport intracellular protein transport GTPase activator activity endosome|clathrin-coated vesicle
YPR106W YPR106W ISR1 hom Verified 1.25069811303811 0.105522319588236 no 563 0.108687996068329 426 NA FT PROTEIN PHOSPHORYLATION Predicted protein kinase, overexpression causes sensitivity to staurosporine, which is a potent inhibitor of protein kinase C biological_process protein kinase activity cellular_component
YOR221C YOR221C MCT1 hom Verified 1.24817948939836 0.105982666707819 no 564 0.137988936604428 517 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Predicted malonyl-CoA:ACP transferase, putative component of a type-II mitochondrial fatty acid synthase that produces intermediates for phospholipid remodeling fatty acid metabolic process|aerobic respiration [acyl-carrier-protein] S-malonyltransferase activity mitochondrion
YNL146C-A_p YNL146C-A YNL146C-A hom Uncharacterized 1.24487893927811 0.106588126776869 no 565 0.0968738279780007 361 NA Putative protein of unknown function biological_process molecular_function cellular_component
YPL002C YPL002C SNF8 hom Verified 1.24354015734982 0.106834426277705 no 566 0.130701213428596 514 NA FF|FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression negative regulation of transcription from RNA polymerase II promoter by glucose|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein targeting to vacuole molecular_function ESCRT II complex
YMR303C YMR303C ADH2 hom Verified 1.24104117133871 0.107295269956447 no 567 0.106206117741233 395 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1 ethanol metabolic process|NADH oxidation|fermentation|amino acid catabolic process to alcohol via Ehrlich pathway alcohol dehydrogenase (NAD) activity cytoplasm
YOL051W YOL051W GAL11 hom Verified 1.24103647714819 0.107296136969254 no 568 0.176302684940446 652 NA FF|FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors; forms part of the tail domain of mediator negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly|TFIIE-class binding transcription factor activity|RNA polymerase II activating transcription factor binding|TFIIE-class transcription factor binding|TFIIH-class transcription factor binding|RNA polymerase II transcription factor recruiting transcription factor activity core mediator complex
YMR243C YMR243C ZRC1 hom Verified 1.23924017296134 0.107628283626502 no 569 0.106062139627307 436 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Vacuolar membrane zinc transporter; transports zinc from cytosol to vacuole for storage; also has role in resistance to zinc shock resulting from sudden influx of zinc into cytoplasm; human ortholog SLC30A10 functions as a Mn transporter and mutations in SLC30A10 cause neurotoxic accumulation of Mn in liver and brain; ZRC1 has a paralog, COT1, that arose from the whole genome duplication cobalt ion transport|cellular zinc ion homeostasis|zinc ion transport|glutathione metabolic process zinc ion transmembrane transporter activity|inorganic cation transmembrane transporter activity integral to membrane|fungal-type vacuole
YER079W_p YER079W YER079W hom Uncharacterized 1.2388436980512 0.107701693744395 no 570 0.099349572109306 356 NA FT NUCLEUS Putative protein of unknown function biological_process molecular_function nucleus|cytoplasm
YOR255W YOR255W OSW1 hom Verified 1.23804412661801 0.107849849732828 no 571 0.103607088252329 413 NA FT CELL WALL ORG/BIOGENESIS Protein involved in sporulation; required for the construction of the outer spore wall layers; required for proper localization of Spo14p ascospore wall assembly|ascospore formation molecular_function prospore membrane
YOR339C YOR339C UBC11 hom Verified 1.23670870758655 0.108097622412176 no 572 0.0990357298676699 345 NA Ubiquitin-conjugating enzyme most similar in sequence to Xenopus ubiquitin-conjugating enzyme E2-C, but not a true functional homolog of this E2; unlike E2-C, not required for the degradation of mitotic cyclin Clb2 protein polyubiquitination|protein monoubiquitination ubiquitin-protein ligase activity cytoplasm
YPL147W YPL147W PXA1 hom Verified 1.23486587433416 0.108440212928675 no 573 0.0987808751679127 371 NA FT NUCLEOTIDE METABOLISM Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter ABCD1 and ABCD2 and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder fatty acid transport ATPase activity, coupled to transmembrane movement of substances integral to membrane|integral to peroxisomal membrane
YGL237C YGL237C HAP2 hom Verified 1.23292750171976 0.108801406878681 no 574 0.0958832260288616 383 NA FT TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding carbon catabolite activation of transcription from RNA polymerase II promoter|regulation of cellular respiration RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription CCAAT-binding factor complex|nucleus
YJL171C YJL171C YJL171C hom Verified 1.23251511059394 0.10887836279901 no 575 0.0829370626296302 286 NA FT MITOCHONDRION|PLASMA MEMBRANE GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress biological_process molecular_function mitochondrion|fungal-type cell wall|plasma membrane
YGR022C_d YGR022C YGR022C hom Dubious 1.23168237188177 0.109033878663644 no 576 0.078041837538738 298 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W Unknown Unknown Unknown
YNL087W YNL087W TCB2 hom Verified 1.2315536422229 0.109057933463315 no 577 0.113252254481003 416 NA FT ENDOPLASMIC RETICULUM|PLASMA MEMBRANE ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains 3 calcium and lipid binding domains; mRNA is targeted to the bud biological_process lipid binding cellular bud|cortical endoplasmic reticulum
YKL143W YKL143W LTV1 hom Verified 1.23057940819249 0.109240105344741 no 578 0.0978594354618616 412 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RESPONSE TO OXIDATIVE STRESS NUCLEUS Component of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; required for ribosomal small subunit export from nucleus; required for growth at low temperature ribosomal small subunit biogenesis|cellular response to oxidative stress|response to osmotic stress|ribosomal small subunit export from nucleus molecular_function preribosome, small subunit precursor|EGO complex|nucleus|late endosome membrane|cytoplasm
YAL022C YAL022C FUN26 hom Verified 1.23055407070059 0.109244846113979 no 579 0.109561344110933 400 NA Vacuolar membrane transporter with broad nucleoside selectivity; may regulate balance of nicotinamide riboside (NmR) levels between cytosol and vacuole, contributing to salvage of NmR for use in cytosolic NAD+ synthesis nucleoside transport|nicotinamide riboside transport|transmembrane transport nicotinamide riboside transporter activity|nucleoside transmembrane transporter activity fungal-type vacuole membrane|integral to membrane|intracellular|membrane
YLR170C YLR170C APS1 hom Verified 1.23042918522135 0.109268214960618 no 580 0.123359774597919 451 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex Golgi to vacuole transport|vesicle-mediated transport clathrin binding AP-1 adaptor complex
YML117W YML117W NAB6 hom Verified 1.22887975749199 0.109558446029055 no 581 0.10626381886538 405 NA Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP biological_process molecular_function cytoplasm
YOR283W YOR283W YOR283W hom Verified 1.22847892449663 0.109633618108562 no 582 0.105504239930595 388 NA FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Phosphatase with a broad substrate specificity and some similarity to GPM1/YKL152C, a phosphoglycerate mutase; YOR283W is not an essential gene dephosphorylation phosphatase activity nucleus|cytoplasm
YKL073W YKL073W LHS1 hom Verified 1.22797891578022 0.10972744146833 no 583 0.134625320897176 512 NA FT PROTEIN LOCALIZATION|NUCLEOTIDE METABOLISM ENDOPLASMIC RETICULUM Molecular chaperone of the endoplasmic reticulum lumen, involved in polypeptide translocation and folding; nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; regulated by the unfolded protein response pathway posttranslational protein targeting to membrane, translocation|response to unfolded protein unfolded protein binding|adenyl-nucleotide exchange factor activity|ATP binding endoplasmic reticulum lumen
YLR025W YLR025W SNF7 hom Verified 1.22773255800335 0.109773690081114 no 584 0.192045360584699 717 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes cellular response to anoxia|intralumenal vesicle formation|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|late endosome to vacuole transport protein binding ESCRT III complex|cytoplasm
YHL025W YHL025W SNF6 hom Verified 1.22736653801671 0.109842428650787 no 585 0.115444539753129 304 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CARBOHYDRATE METABOLISM NUCLEUS RSC COMPLEX Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf5p; relocates to the cytosol under hypoxic conditions sucrose catabolic process|nucleotide-excision repair|chromatin remodeling|positive regulation of transcription from RNA polymerase II promoter molecular_function SWI/SNF complex|nucleus
YNL127W YNL127W FAR11 hom Verified 1.22380847519609 0.110512243203908 no 586 0.156921757960541 599 NA FT CELL CYCLE|SIGNALING Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far10p; has similarity to the N- and C-termini of N. crassa HAM-2 re-entry into mitotic cell cycle after pheromone arrest molecular_function cellular_component
YOL129W YOL129W VPS68 hom Verified 1.22104496099818 0.11103449847449 no 587 0.122898536788478 491 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT MITOCHONDRION Vacuolar membrane protein of unknown function involved in vacuolar protein sorting; also detected in the mitochondria late endosome to vacuole transport via multivesicular body sorting pathway|protein targeting to vacuole molecular_function Vps55/Vps68 complex|mitochondrion|fungal-type vacuole membrane|integral to membrane
YPL203W YPL203W TPK2 hom Verified 1.22016765182053 0.111200663442023 no 588 0.107659409233313 442 NA FT SIGNALING|PROTEIN PHOSPHORYLATION NUCLEUS cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk3p; localizes to P-bodies during stationary phase protein phosphorylation|Ras protein signal transduction|invasive growth in response to glucose limitation cAMP-dependent protein kinase activity|protein kinase activity nucleus|cAMP-dependent protein kinase complex
YKL160W YKL160W ELF1 hom Verified 1.2193485033362 0.111355973262471 no 589 0.104382924562665 407 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS Transcription elongation factor that contains a conserved zinc finger domain; implicated in the maintenance of proper chromatin structure in actively transcribed regions; deletion inhibits Brome mosaic virus (BMV) gene expression regulation of transcription by chromatin organization|transcription elongation from RNA polymerase II promoter RNA polymerase II core binding transcription elongation factor complex|nucleus
YDR171W YDR171W HSP42 hom Verified 1.21368362471511 0.112434279929308 no 590 0.0894120490429559 298 NA FT CYTOSKELETON ORGANIZATION CYTOSKELETON Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress cytoskeleton organization unfolded protein binding cytoskeleton|chaperonin-containing T-complex|cytoplasm
YMR140W YMR140W SIP5 hom Verified 1.21354347581269 0.112461051431979 no 591 0.10392120480476 383 NA FT RESPONSE TO NUTRIENT LEVELS Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase; forms cytoplasmic foci upon DNA replication stress cellular response to glucose starvation molecular_function cytoplasm
YNL184C_p YNL184C YNL184C hom Uncharacterized 1.21268508610948 0.112625121986837 no 592 0.136785545714351 489 NA Protein of unknown function; expressed at both mRNA and protein levels biological_process molecular_function cellular_component
YPL077C_p YPL077C YPL077C hom Uncharacterized 1.21265944372488 0.11263002583917 no 593 0.116080323974182 434 NA Putative protein of unknown function; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene; YPL077C has a paralog, YBR197C, that arose from the whole genome duplication biological_process molecular_function cellular_component
YPL194W YPL194W DDC1 hom Verified 1.21206858210248 0.11274306452044 no 594 0.100001559152462 374 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME DNA damage checkpoint protein; part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate; forms nuclear foci upon DNA replication stress meiosis|mitotic cell cycle G1/S transition checkpoint|intra-S DNA damage checkpoint|recombinational repair|G2/M transition checkpoint|cell cycle checkpoint molecular_function condensed nuclear chromosome|checkpoint clamp complex
YEL011W YEL011W GLC3 hom Verified 1.21129450400863 0.112891277184622 no 595 0.0945728765395077 356 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress glycogen biosynthetic process 1,4-alpha-glucan branching enzyme activity cytoplasm
YBR039W YBR039W ATP3 hom Verified 1.21128883549283 0.11289236304759 no 596 0.136569317460553 523 NA FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS MITOCHONDRION Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis ATP synthesis coupled proton transport proton-transporting ATPase activity, rotational mechanism mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase, central stalk
YGL224C YGL224C SDT1 hom Verified 1.2096255743564 0.113211300079805 no 597 0.108260092247265 420 NA Pyrimidine nucleotidase; overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II, as well as resistance to other pyrimidine derivatives pyrimidine nucleobase metabolic process nucleotidase activity cellular_component
YMR001C-A_p YMR001C-A YMR001C-A hom Uncharacterized 1.20749673003787 0.113620451808671 no 598 0.102754424741396 460 NA Putative protein of unknown function biological_process molecular_function cellular_component
YKR097W YKR097W PCK1 hom Verified 1.20507744525112 0.114086703007274 no 599 0.112805531445817 482 NA FT CARBOHYDRATE METABOLISM Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol gluconeogenesis phosphoenolpyruvate carboxykinase (ATP) activity cytosol
YLR111W_d YLR111W YLR111W hom Dubious 1.20141104866739 0.114795896188989 no 600 0.13614729357361 604 NA FF Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YAL008W YAL008W FUN14 hom Verified 1.20118466096171 0.114839789074297 no 601 0.134386874787135 448 NA FT MITOCHONDRION Mitochondrial protein of unknown function biological_process molecular_function mitochondrial outer membrane|mitochondrion
YDR031W YDR031W MIC14 hom Verified 1.19838363368603 0.11538385048262 no 602 0.0972228469614584 290 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS|MITOCHONDRION Mitochondrial intermembrane space protein of unknown function; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress aerobic respiration molecular_function nucleus|mitochondrial intermembrane space|cytoplasm
YLR069C YLR069C MEF1 hom Verified 1.19834266328887 0.115391821994207 no 603 0.126530096967725 489 NA FT TRANSLATION|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial elongation factor involved in translational elongation mitochondrial translational elongation|mitochondrial translation translation elongation factor activity mitochondrion
YML047W-A_d YML047W-A YML047W-A hom Dubious 1.19811379994979 0.115436358583073 no 604 0.109522203899381 404 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YKR065C YKR065C PAM17 hom Verified 1.1980907943488 0.115440836126783 no 605 0.0914331861093603 365 NA FT PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Constituent of the TIM23 complex; proposed alternatively to be a component of the import motor (PAM complex) or to interact with and modulate the core TIM23 (Translocase of the Inner mitochondrial Membrane) complex; protein abundance increases in response to DNA replication stress protein import into mitochondrial matrix molecular_function mitochondrion|presequence translocase-associated import motor
YJR019C YJR019C TES1 hom Verified 1.19777539121594 0.115502234984355 no 606 0.110492835151561 370 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM MITOCHONDRION Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids fatty acid beta-oxidation|fatty acid oxidation acyl-CoA hydrolase activity mitochondrion|peroxisome
YNL332W YNL332W THI12 hom Verified 1.19686311440103 0.115679956579637 no 607 0.100516556071014 410 NA Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13 thiamine biosynthetic process molecular_function cellular_component
YPL258C YPL258C THI21 hom Verified 1.19601554246255 0.11584524693638 no 608 0.107605206630792 415 NA Hydroxymethylpyrimidine (HMP) and HMP-phosphate kinase; involved in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p thiamine biosynthetic process phosphomethylpyrimidine kinase activity|hydroxymethylpyrimidine kinase activity cellular_component
YMR062C YMR062C ARG7 hom Verified 1.19535215004454 0.115974736235058 no 609 0.151439007899844 555 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS MITOCHONDRION Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine fungal-type cell wall organization|ornithine biosynthetic process|arginine biosynthetic process acetyl-CoA:L-glutamate N-acetyltransferase activity|glutamate N-acetyltransferase activity mitochondrion|mitochondrial matrix
YHR091C YHR091C MSR1 hom Verified 1.19492053706685 0.116059039056373 no 610 0.116850574165102 460 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial arginyl-tRNA synthetase; mutations in human ortholog are associated with pontocerebellar hypoplasia type 6 arginyl-tRNA aminoacylation|mitochondrial arginyl-tRNA aminoacylation|mitochondrial translation arginine-tRNA ligase activity mitochondrion
YOR018W YOR018W ROD1 hom Verified 1.19100718181349 0.116825382751998 no 611 0.0988986669280783 365 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION PLASMA MEMBRANE Membrane protein, binds the ubiquitin ligase Rsp5p via its 2 PY motifs; overexpression confers resistance to the GST substrate o-dinitrobenzene, zinc, and calcium; proposed to regulate the endocytosis of plasma membrane proteins; protein abundance increases in response to DNA replication stress; ROD1 has a paralog, ROG3, that arose from the whole genome duplication response to drug|ubiquitin-dependent endocytosis ubiquitin protein ligase binding plasma membrane
YJL060W YJL060W BNA3 hom Verified 1.19053371683962 0.116918343029314 no 612 0.114604227636884 443 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Kynurenine aminotransferase, catalyzes formation of kynurenic acid from kynurenine; potential Cdc28p substrate kynurenic acid biosynthetic process arylformamidase activity|kynurenine-oxoglutarate transaminase activity mitochondrion|cytoplasm
YBR101C YBR101C FES1 hom Verified 1.18835988871547 0.117345826107745 no 613 0.11600877596478 449 NA FT TRANSLATION RIBOSOME Hsp70 (Ssa1p) nucleotide exchange factor; cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum; protein abundance increases in response to DNA replication stress cytoplasmic translation adenyl-nucleotide exchange factor activity cytosol|cytosolic ribosome
YFR014C YFR014C CMK1 hom Verified 1.18798702162511 0.117419261457165 no 614 0.0905648711572707 291 NA FT SIGNALING|PROTEIN PHOSPHORYLATION Calmodulin-dependent protein kinase; may play a role in stress response, many Ca++/calmodulin dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK1 has a paralog, CMK2, that arose from the whole genome duplication signal transduction|protein phosphorylation protein kinase activity|calmodulin-dependent protein kinase activity cytoplasm
YDR030C YDR030C RAD28 hom Verified 1.18689316381042 0.117634882084076 no 615 0.117327398671337 405 NA FT RESPONSE TO DNA DAMAGE NUCLEUS Protein involved in DNA repair, related to the human CSA protein that is involved in transcription-coupled repair nucleotide excision repair DNA repair molecular_function nucleus
YOR158W YOR158W PET123 hom Verified 1.18666428431688 0.117680034113788 no 616 0.129769574870059 470 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YBL029C-A YBL029C-A YBL029C-A hom Verified 1.18563694086006 0.117882853615245 no 617 0.118840148029927 415 NA FT PLASMA MEMBRANE Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; protein abundance increases in response to DNA replication stress; has potential orthologs in Saccharomyces species and in Yarrowia lipolytica biological_process molecular_function plasma membrane
YLL051C YLL051C FRE6 hom Verified 1.18304860551131 0.118394942341025 no 618 0.0882372013398777 353 NA FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels intracellular sequestering of iron ion|copper ion import ferric-chelate reductase activity fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YML002W_p YML002W YML002W hom Uncharacterized 1.18167706617701 0.11866693077682 no 619 0.0993775863831082 366 NA Putative protein of unknown function; expression induced by heat and by calcium shortage biological_process molecular_function cellular_component
YPL015C YPL015C HST2 hom Verified 1.18146157942718 0.118709703810816 no 620 0.139615108530856 463 NA FT GENE SILENCING NUCLEUS Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro; contains a nuclear export signal (NES); function regulated by its nuclear export negative regulation of chromatin silencing at telomere|chronological cell aging|chromatin silencing at rDNA|negative regulation of mitotic recombination NAD-dependent histone deacetylase activity cytoplasm
YCR071C YCR071C IMG2 hom Verified 1.18060860693099 0.118879121438521 no 621 0.13336734279652 480 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YLR290C_p YLR290C YLR290C hom Uncharacterized 1.17956532195841 0.119086571056322 no 622 0.089063176430424 304 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR290C is not an essential gene biological_process molecular_function mitochondrion
YMR070W YMR070W MOT3 hom Verified 1.17878000008058 0.119242895101229 no 623 0.151050402429058 559 NA FT TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM NUCLEUS Transcriptional repressor and activator with two C2-H2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes in response to hyperosmotic stress; contributes to recruitment of the Tup1p-Cyc8p general repressor to promoters; involved in positive transcriptional regulation of CWP2 and other genes; can form the [MOT3+] prion cellular hyperosmotic response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of ergosterol biosynthetic process|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II repressing transcription factor binding|RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding nucleus
YPR032W YPR032W SRO7 hom Verified 1.17877558240542 0.119243774881145 no 624 0.122044503760973 476 NA FT VESICLE-MEDIATED TRANSPORT|SIGNALING PLASMA MEMBRANE Effector of Rab GTPase Sec4p; forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lgl tumor suppressor; SRO7 has a paralog, SRO77, that arose from the whole genome duplication establishment of cell polarity|exocytosis|Golgi to plasma membrane transport|small GTPase mediated signal transduction SNARE binding|Rab GTPase binding cytosol|plasma membrane
YMR101C YMR101C SRT1 hom Verified 1.1780214636921 0.11939402475544 no 625 0.0962873680623764 333 NA FT CARBOHYDRATE METABOLISM Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase protein glycosylation dehydrodolichyl diphosphate synthase activity|prenyltransferase activity lipid particle
YDL237W YDL237W AIM6 hom Verified 1.17778569406372 0.119441026664749 no 626 0.123353326195998 415 NA Putative protein of unknown function, required for respiratory growth; YDL237W is not an essential gene biological_process molecular_function cellular_component
YBR005W YBR005W RCR1 hom Verified 1.17569983173411 0.119857422946669 no 627 0.108955943492484 399 NA FT VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein of the ER membrane involved in cell wall chitin deposition; may function in the endosomal-vacuolar trafficking pathway, helping determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR1 has a paralog, RCR2, that arose from the whole genome duplication fungal-type cell wall organization|vesicle-mediated transport molecular_function integral to endoplasmic reticulum membrane
YDR152W YDR152W GIR2 hom Verified 1.17404274857113 0.120188951666262 no 628 0.122129178898754 467 NA FT TRANSLATION Highly-acidic cytoplasmic RWD domain-containing protein of unknown function; forms a complex with Rbg2p; interacts with Rbg1p and Gcn1p; associates with translating ribosomes; putative intrinsically unstructured protein cytoplasmic translation molecular_function polysome|cytoplasm
YOL033W YOL033W MSE1 hom Verified 1.17377459486366 0.120242661227489 no 629 0.154758102040193 529 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial glutamyl-tRNA synthetase, predicted to be palmitoylated mitochondrial glutamyl-tRNA aminoacylation|glutamyl-tRNA aminoacylation|mitochondrial translation glutamate-tRNA(Gln) ligase activity|glutamate-tRNA ligase activity mitochondrion
YEL071W YEL071W DLD3 hom Verified 1.17301776663424 0.120394340538387 no 630 0.113932368352974 380 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS D-lactate dehydrogenase, part of the retrograde regulon which consists of genes whose expression is stimulated by damage to mitochondria and reduced in cells grown with glutamate as the sole nitrogen source, located in the cytoplasm lactate metabolic process|filamentous growth D-lactate dehydrogenase (cytochrome) activity cytoplasm
YLR392C YLR392C ART10 hom Verified 1.17060825361483 0.12087813910294 no 631 0.0863427842852196 359 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION Protein of unknown function that contains 2 PY motifs and is ubiquinated by Rsp5p; overexpression confers resistance to arsenite; green fluorescent protein (GFP)-fusion protein localizes it to the cytoplasm; non-essential gene biological_process molecular_function cytoplasm
YIL148W YIL148W RPL40A hom Verified 1.17008236184621 0.120983912900631 no 632 0.126814916607377 446 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RESPONSE TO DNA DAMAGE|TRANSLATION NUCLEUS RIBOSOME Ubiquitin-ribosomal 60S subunit protein L40A fusion protein; cleaved to yield ubiquitin and ribosomal protein L40A; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40A has a paralog, RPL40B, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress cytoplasmic translation|protein ubiquitination|ribosome biogenesis structural constituent of ribosome|protein tag cytosolic large ribosomal subunit
YGL228W YGL228W SHE10 hom Verified 1.16926327941485 0.121148786472815 no 633 0.117505973379476 458 NA FT MITOCHONDRION Putative glycosylphosphatidylinositol (GPI)-anchored protein of unknown function; overexpression causes growth arrest biological_process molecular_function cellular_component
YDR019C YDR019C GCV1 hom Verified 1.16908099415993 0.121185500265957 no 634 0.134155169987472 477 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION T subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm glycine catabolic process|glycine metabolic process|one-carbon metabolic process glycine dehydrogenase (decarboxylating) activity mitochondrion|glycine cleavage complex
YGL208W YGL208W SIP2 hom Verified 1.1671641715996 0.121572038395249 no 635 0.109564294869595 425 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|SIGNALING|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS PLASMA MEMBRANE One of three beta subunits of the Snf1 serine/threonine protein kinase complex involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and the plasma membrane cellular response to glucose starvation|signal transduction|protein phosphorylation|replicative cell aging|invasive growth in response to glucose limitation|regulation of protein complex assembly AMP-activated protein kinase activity AMP-activated protein kinase complex|plasma membrane|cytoplasm
YPL219W YPL219W PCL8 hom Verified 1.16618850273988 0.121769120001726 no 636 0.13967932308387 483 NA FT CELL CYCLE|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylation negative regulation of glycogen biosynthetic process cyclin-dependent protein kinase regulator activity cyclin-dependent protein kinase holoenzyme complex
YNL105W_d YNL105W RRT16 hom Dubious 1.16474562079323 0.12206098825301 no 637 0.0883880135460054 314 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription Unknown Unknown Unknown
YLR264C-A_p YLR264C-A YLR264C-A hom Uncharacterized 1.16343762726584 0.1223259953008 no 638 0.123387143132192 467 NA Putative protein of unknown function biological_process molecular_function cellular_component
YDL127W YDL127W PCL2 hom Verified 1.16342876679161 0.122327791860131 no 639 0.0846318253392524 350 NA FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION NUCLEUS|SITE OF POLARIZED GROWTH Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; localizes to sites of polarized cell growth G1 phase of mitotic cell cycle|regulation of establishment or maintenance of cell polarity|regulation of cyclin-dependent protein kinase activity|septin ring organization cyclin-dependent protein kinase regulator activity cyclin-dependent protein kinase holoenzyme complex|incipient cellular bud site|nucleus|cellular bud neck|cellular bud tip
YIL072W YIL072W HOP1 hom Verified 1.16324940168807 0.122364164104554 no 640 0.155126352776791 527 NA FT CELL CYCLE NUCLEUS|CHROMOSOME Meiosis-specific protein required for chromosome synapsis; displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex; required for chiasma formation; in vitro, displays the ability to promote intra- and intermolecular synapsis between double-stranded DNA molecules and to fold DNA into rigid protein?DNA filaments synaptonemal complex assembly|meiotic recombination checkpoint|synapsis four-way junction DNA binding condensed nuclear chromosome|lateral element
YLR374C_d YLR374C YLR374C hom Dubious 1.1624281674242 0.122530793618015 no 641 0.17596187417808 611 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF STP3/YLR375W Unknown Unknown Unknown
YDR442W_d YDR442W YDR442W hom Dubious 1.16227622394458 0.122561640595186 no 642 0.155877715649551 509 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YIL070C YIL070C MAM33 hom Verified 1.16060176806622 0.1229019430447 no 643 0.139543643611901 499 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Acidic protein of the mitochondrial matrix involved in oxidative phosphorylation; related to the human complement receptor gC1q-R aerobic respiration molecular_function mitochondrion|mitochondrial matrix
YIL011W YIL011W TIR3 hom Verified 1.16019982685361 0.122983728735924 no 644 0.102535063833469 398 NA Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth biological_process molecular_function fungal-type cell wall
YOL143C YOL143C RIB4 hom Verified 1.15962568253067 0.123100619922256 no 645 0.136376216218337 475 NA FT NUCLEUS Lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, also known as DMRL synthase); catalyzes synthesis of immediate precursor to riboflavin riboflavin biosynthetic process 6,7-dimethyl-8-ribityllumazine synthase activity nucleus|cytoplasm
YLR037C YLR037C PAU23 hom Verified 1.15931109504017 0.12316470042976 no 646 0.123784546308732 465 NA FT CELL WALL ORG/BIOGENESIS Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth biological_process molecular_function fungal-type cell wall
YIR034C YIR034C LYS1 hom Verified 1.15838772083413 0.123352923928503 no 647 0.140361508390831 462 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS Saccharopine dehydrogenase (NAD+, L-lysine-forming), catalyzes the conversion of saccharopine to L-lysine, which is the final step in the lysine biosynthesis pathway; also has mRNA binding activity lysine biosynthetic process|lysine biosynthetic process via aminoadipic acid saccharopine dehydrogenase (NAD+, L-lysine-forming) activity|mRNA binding cytoplasm
YPL267W YPL267W ACM1 hom Verified 1.15829211888649 0.123372423236443 no 648 0.135041491179723 516 NA FT CELL CYCLE|CELL DIVISION NUCLEUS Pseudosubstrate inhibitor of the anaphase-promoting complex/cyclosome (APC/C), that suppresses APC/C [Cdh1]-mediated proteolysis of mitotic cyclins; associates with Cdh1p, Bmh1p and Bmh2p; cell cycle regulated protein negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle ubiquitin-protein ligase inhibitor activity nucleus|cytoplasm
YOR322C YOR322C LDB19 hom Verified 1.1580505711815 0.123421699772473 no 649 0.161174398996973 562 NA FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION GOLGI APPARATUS|PLASMA MEMBRANE Protein involved in regulating the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target; inhibited by Npr1p-mediated phosphorylation, which affects translocation between the cytosol and the plasma membrane; null mutant has reduced affinity for alcian blue dye ubiquitin-dependent endocytosis ubiquitin protein ligase binding cytosol|Golgi apparatus|plasma membrane|clathrin-coated vesicle|cytoplasm
YDR467C_d YDR467C YDR467C hom Dubious 1.15754614790657 0.123524648255317 no 650 0.131207112375898 447 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YKR045C_p YKR045C YKR045C hom Uncharacterized 1.15569099983907 0.123903785417508 no 651 0.124321548973105 474 NA Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm biological_process molecular_function cytoplasm
YMR313C YMR313C TGL3 hom Verified 1.1523331392626 0.124592102089625 no 652 0.118100406009099 433 NA FT LIPID METABOLISM|CELL DIVISION Bifunctional enzyme with triacylglycerol lipase and lysophosphatidylethanolamine acyltransferase activity; responsible for all the triacylglycerol lipase activity of the lipid particle; required with Tgl4p for timely bud formation triglyceride catabolic process|cell budding|cellular lipid metabolic process triglyceride lipase activity|lysophosphatidylethanolamine acyltransferase activity lipid particle
YBR051W_d YBR051W YBR051W hom Dubious 1.14715109711114 0.125659589394993 no 653 0.123631695865887 437 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partiallly overlaps the REG2/YBR050C regulatory subunit of the Glc7p type-1 protein phosphatase Unknown Unknown Unknown
YDR415C_p YDR415C YDR415C hom Uncharacterized 1.1442673157054 0.126256396815314 no 654 0.0992872862393164 363 NA FT PROTEOLYSIS Putative aminopeptidase biological_process molecular_function cellular_component
YGR038W YGR038W ORM1 hom Verified 1.14373500608119 0.126366775546481 no 655 0.16239375518503 551 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Evolutionarily conserved protein, similar to Orm2p, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control cellular sphingolipid homeostasis|negative regulation of sphingolipid biosynthetic process|response to unfolded protein molecular_function integral to membrane|endoplasmic reticulum|SPOTS complex
YOL013C YOL013C HRD1 hom Verified 1.14048447670473 0.12704225815923 no 656 0.099980446440407 428 NA FT CELL WALL ORG/BIOGENESIS|PROTEOLYSIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM UBIQUITIN LIGASE COMPLEX Ubiquitin-protein ligase; required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; likely plays a general role in targeting proteins that persistently associate with and potentially obstruct the ER-localized translocon fungal-type cell wall organization|ER-associated protein catabolic process ubiquitin-protein ligase activity Hrd1p ubiquitin ligase ERAD-M complex|integral to membrane|Hrd1p ubiquitin ligase ERAD-L complex|endoplasmic reticulum membrane
YML036W YML036W CGI121 hom Verified 1.13952269311645 0.127242604356545 no 657 0.149510902790782 514 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS|CHROMOSOME Component of the EKC/KEOPS complex with Bud32p, Kae1p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription; Cgi121p is dispensable for tRNA modification telomere maintenance|positive regulation of transcription from RNA polymerase II promoter molecular_function EKC/KEOPS complex
YHR016C YHR016C YSC84 hom Verified 1.13721673028076 0.127723847345186 no 658 0.132972991350857 485 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION CYTOSKELETON Actin-binding protein; involved in bundling of actin filaments and endocytosis of actin cortical patches; activity stimulated by Las17p; contains SH3 domain similar to Rvs167p; YSC84 has a paralog, LSB3, that arose from the whole genome duplication endocytosis|actin filament organization|actin filament bundle assembly|actin cortical patch localization|actin cytoskeleton organization actin filament binding actin cortical patch
YBL060W YBL060W YEL1 hom Verified 1.13615731895855 0.127945364815899 no 659 0.138571257300458 492 NA FT PROTEIN LOCALIZATION|LIPID METABOLISM|SIGNALING SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Guanine nucleotide exchange factor specific for Arf3p; localized to the bud neck and tip; required for localization of Arf3p to the bud neck and tip positive regulation of phosphatidylinositol biosynthetic process|protein localization|actin cortical patch localization ARF guanyl-nucleotide exchange factor activity cellular bud neck|cellular bud tip|cytoplasm
YDR287W YDR287W INM2 hom Verified 1.1361005065189 0.127957251541992 no 660 0.127535147761632 462 NA FT LIPID METABOLISM|CARBOHYDRATE METABOLISM Inositol monophosphatase, involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy inositol phosphate dephosphorylation inositol monophosphate 1-phosphatase activity cellular_component
YPL149W YPL149W ATG5 hom Verified 1.13435294927218 0.128323263452212 no 661 0.110741985708628 433 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Conserved protein involved in autophagy and the Cvt pathway; undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation; conjugated Atg12p also forms a complex with Atg16p that is essential for autophagosome formation C-terminal protein lipidation|mitochondrion degradation|piecemeal microautophagy of nucleus|macroautophagy|CVT pathway Atg8 ligase activity cytosol|Atg12-Atg5-Atg16 complex|pre-autophagosomal structure|autophagic vacuole
YBR277C_d YBR277C YBR277C hom Dubious 1.13269229128471 0.128671748008705 no 662 0.132378838755192 518 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR278W Unknown Unknown Unknown
YNL097C YNL097C PHO23 hom Verified 1.13083632431497 0.129061994043873 no 663 0.120045413095403 503 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5; affects termination of snoRNAs and cryptic unstable transcripts (CUTs); C-terminus has similarity to human candidate tumor suppressor p33(ING1) and its isoform ING3 positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of transcription from RNA polymerase I promoter|negative regulation of chromatin silencing at telomere|negative regulation of chromatin silencing at rDNA|chromatin modification|positive regulation of transcription from RNA polymerase II promoter methylated histone residue binding histone deacetylase complex|Rpd3L-Expanded complex|nucleus|Rpd3L complex
YBL045C YBL045C COR1 hom Verified 1.12663304378714 0.129948831090486 no 664 0.139680804764879 431 NA FT OXIDATION-REDUCTION PROCESS|PROTEOLYSIS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Core subunit of the ubiquinol-cytochrome c reductase complex (bc1 complex), which is a component of the mitochondrial inner membrane electron transport chain aerobic respiration ubiquinol-cytochrome-c reductase activity mitochondrion|integral to membrane|mitochondrial respiratory chain complex III
YML086C YML086C ALO1 hom Verified 1.1266205524956 0.12995147286068 no 665 0.10484406527126 393 NA FT OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS MITOCHONDRION D-Arabinono-1,4-lactone oxidase, catalyzes the final step in biosynthesis of dehydro-D-arabinono-1,4-lactone, which is protective against oxidative stress cellular response to oxidative stress|dehydro-D-arabinono-1,4-lactone biosynthetic process D-arabinono-1,4-lactone oxidase activity mitochondrial outer membrane|mitochondrion|integral to mitochondrial outer membrane
YOR229W YOR229W WTM2 hom Verified 1.12600022789478 0.130082711430989 no 666 0.125836398226663 482 NA FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RESPONSE TO DNA DAMAGE|GENE SILENCING NUCLEUS Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; involved in response to replication stress; contains WD repeats negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of transcription from RNA polymerase II promoter during meiosis|cellular protein complex localization|negative regulation of chromatin silencing at telomere|response to DNA damage stimulus|positive regulation of transcription from RNA polymerase II promoter protein binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|transcription corepressor activity nucleus
YDR313C YDR313C PIB1 hom Verified 1.12590955323605 0.130101902637513 no 667 0.127337547825926 486 NA RING-type ubiquitin ligase of the endosomal and vacuolar membranes, binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain protein ubiquitination ubiquitin-protein ligase activity|phosphatidylinositol-3-phosphate binding fungal-type vacuole membrane|late endosome
YOL068C YOL068C HST1 hom Verified 1.12579327562687 0.130126515551839 no 668 0.140366655894798 528 NA FT CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME NAD(+)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing and mitotic repression; non-essential subunit of the Set3C deacetylase complex; involved in telomere maintenance chromatin silencing|negative regulation of mitotic recombination|histone deacetylation NAD-independent histone deacetylase activity|NAD-dependent histone deacetylase activity Set3 complex
YPL157W YPL157W TGS1 hom Verified 1.12520245335708 0.130251626883407 no 669 0.127915515318058 513 NA FT CELL CYCLE|RNA PROCESSING NUCLEUS Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs meiosis|RNA methylation|nucleologenesis|7-methylguanosine cap hypermethylation|regulation of telomere maintenance via telomerase RNA methyltransferase activity nucleolus
YMR158C-A_p YMR158C-A YMR158C-A hom Uncharacterized 1.12395592632938 0.130515861892311 no 670 0.11313562446733 422 NA Putative protein of unknown function, may contain a lipid attachment site; YMR158C-A is not an essential gene biological_process molecular_function cellular_component
YJR151W-A_p YJR151W-A YJR151W-A hom Uncharacterized 1.12096577309237 0.131151215876488 no 671 0.123003859318444 404 NA Putative protein of unknown function; identified by fungal homology and RT-PCR; predicted to have a role in transcription based on computational guilt by association analysis biological_process molecular_function cellular_component
YGL184C YGL184C STR3 hom Verified 1.12033851743987 0.131284767093515 no 672 0.139557855746854 509 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Peroxisomal cystathionine beta-lyase, converts cystathionine into homocysteine; may be redox regulated by Gto1p methionine biosynthetic process|transsulfuration cystathionine beta-lyase activity peroxisome
YOR291W YOR291W YPK9 hom Verified 1.11999745958821 0.131357422326873 no 673 0.112685173805634 365 NA FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome biological_process molecular_function fungal-type vacuole membrane|integral to membrane
YMR012W YMR012W CLU1 hom Verified 1.11972447532593 0.131415595908082 no 674 0.119817115433843 431 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION eIF3 component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation, can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant translational initiation|mitochondrion organization molecular_function eukaryotic translation initiation factor 3 complex|cytoplasm
YBL104C YBL104C SEA4 hom Verified 1.11963142435855 0.131435429349838 no 675 0.192709607661062 669 NA Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; has an N-terminal beta-propeller fold and a C-terminal RING motif; promoter contains multiple GCN4 binding sites biological_process molecular_function Seh1-associated complex|extrinsic to fungal-type vacuolar membrane|cytoplasm
YHR017W YHR017W YSC83 hom Verified 1.11803751566892 0.131775485510273 no 676 0.160790135881178 622 NA FT MITOCHONDRION Non-essential mitochondrial protein of unknown function; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83 biological_process molecular_function mitochondrial outer membrane|mitochondrion
YDL172C_d YDL172C YDL172C hom Dubious 1.11759572937499 0.131869846782326 no 677 0.154937177145423 563 NA Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YML110C YML110C COQ5 hom Verified 1.11728341013963 0.13193658326211 no 678 0.162701964286352 544 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes ubiquinone biosynthetic process|aerobic respiration 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity mitochondrion|mitochondrial matrix
YJL004C YJL004C SYS1 hom Verified 1.11438645309457 0.132556716233771 no 679 0.19009923285333 699 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation vesicle organization|Golgi to plasma membrane protein transport|Golgi to endosome transport molecular_function trans-Golgi network|integral to membrane|integral to Golgi membrane
YOR338W_p YOR338W YOR338W hom Uncharacterized 1.11434256954726 0.132566125517268 no 680 0.111036377954228 444 NA FT TRANSCRIPTION FROM RNA POL II Putative protein of unknown function; YOR338W transcription is regulated by Azf1p and its transcript is a specific target of the G protein effector Scp160p; identified as being required for sporulation in a high-throughput mutant screen; YOR338W has a paralog, FUN19, that arose from the whole genome duplication ascospore formation|positive regulation of transcription from RNA polymerase II promoter molecular_function cellular_component
YMR002W YMR002W MIC17 hom Verified 1.11336707087742 0.132775405710707 no 681 0.14128108667134 495 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS|MITOCHONDRION Mitochondrial intermembrane space protein; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress aerobic respiration molecular_function nucleus|cytoplasm|mitochondrial intermembrane space
YLR285W YLR285W NNT1 hom Verified 1.11294448030462 0.132866137462933 no 682 0.114204718068945 414 NA FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|GENE SILENCING S-adenosylmethionine-dependent methyltransferase; has a role in rDNA silencing and in lifespan determination chromatin silencing at rDNA|nicotinamide metabolic process S-adenosylmethionine-dependent methyltransferase activity|nicotinamide N-methyltransferase activity cytoplasm
YJL205C YJL205C NCE101 hom Verified 1.1119370583423 0.133082606837026 no 683 0.116270672492591 450 NA FT PROTEIN LOCALIZATION Protein of unknown function, involved in secretion of proteins that lack classical secretory signal sequences protein secretion molecular_function cellular_component
YHR147C YHR147C MRPL6 hom Verified 1.11167326405555 0.133139329605573 no 684 0.155954813339938 553 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YPR040W YPR040W TIP41 hom Verified 1.10914413446117 0.133684004056201 no 685 0.150072478832602 557 NA FT SIGNALING NUCLEUS Protein that interacts with Tap42p, which regulates PP2A; component of the TOR (target of rapamycin) signaling pathway; protein abundance increases in response to DNA replication stress signal transduction molecular_function nucleus|cytoplasm
YGL126W YGL126W SCS3 hom Verified 1.10907710758582 0.133698459801666 no 686 0.142669119225066 519 NA FT LIPID METABOLISM ENDOPLASMIC RETICULUM Protein required for inositol prototrophy; required for normal ER membrane biosynthesis; ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; disputed role in the synthesis of inositol phospholipids from inositol phospholipid metabolic process molecular_function integral to membrane|endoplasmic reticulum
YHL028W YHL028W WSC4 hom Verified 1.10903522126712 0.133707494006673 no 687 0.116573284182414 435 NA FT PROTEIN LOCALIZATION|CELL WALL ORG/BIOGENESIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM ER membrane protein involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3 response to heat|SRP-dependent cotranslational protein targeting to membrane, translocation|protein targeting to ER|response to stress transmembrane signaling receptor activity endoplasmic reticulum membrane
YDR503C YDR503C LPP1 hom Verified 1.10675496191188 0.134199942669301 no 688 0.112238068492718 394 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Lipid phosphate phosphatase, catalyzes Mg(2+)-independent dephosphorylation of phosphatidic acid (PA), lysophosphatidic acid, and diacylglycerol pyrophosphate; involved in control of the cellular levels of phosphatidylinositol and PA phospholipid metabolic process phosphatidate phosphatase activity integral to membrane|membrane
YMR194C-B YMR194C-B CMC4 hom Verified 1.10571017722979 0.134425991790321 no 689 0.115896227785802 427 NA FT MITOCHONDRION Protein that localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; contains twin cysteine-x(9)-cysteine motifs biological_process molecular_function mitochondrial intermembrane space
YLL014W YLL014W EMC6 hom Verified 1.10389059658119 0.13482029922277 no 690 0.164148036331075 619 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93 protein folding in endoplasmic reticulum molecular_function ER membrane protein complex|integral to membrane|endoplasmic reticulum
YNL325C YNL325C FIG4 hom Verified 1.10373225185021 0.134854650394681 no 691 0.149336088566016 530 NA FT LIPID METABOLISM Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase; required for efficient mating and response to osmotic shock; physically associates with and regulated by Vac14p; contains a SAC1-like domain phosphatidylinositol dephosphorylation phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity fungal-type vacuole membrane|PAS complex|extrinsic to membrane
YGR086C YGR086C PIL1 hom Verified 1.10333520108061 0.134940812656262 no 692 0.120670136687266 453 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION MITOCHONDRION Primary protein component of eisosomes; eisosomes are large immobile cell cortex structures associated with endocytosis; null mutant shows activation of Pkc1p/Ypk1p stress resistance pathways; detected in phosphorylated state in mitochondria; member of the BAR domain family; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress eisosome assembly|endocytosis|negative regulation of protein kinase activity|response to heat|protein localization lipid binding mitochondrial outer membrane|eisosome|mitochondrion|plasma membrane|cytoplasm
YGR217W YGR217W CCH1 hom Verified 1.10259152110922 0.135102296997574 no 693 0.131480204846134 445 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together calcium ion transport voltage-gated calcium channel activity|calcium channel activity integral to membrane|plasma membrane
YDR285W YDR285W ZIP1 hom Verified 1.10091950335308 0.135465846438265 no 694 0.141379645543551 507 NA FT CELL CYCLE NUCLEUS|CHROMOSOME Transverse filament protein of the synaptonemal complex; required for normal levels of meiotic recombination and pairing between homologous chromosome during meiosis; potential Cdc28p substrate synapsis|reciprocal meiotic recombination chromatin binding|SUMO polymer binding transverse filament
YHR109W YHR109W CTM1 hom Verified 1.09950019438964 0.135774974619032 no 695 0.109428409110319 425 NA Cytochrome c lysine methyltransferase, trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol; not required for normal respiratory growth peptidyl-lysine methylation [cytochrome c]-lysine N-methyltransferase activity cytosol
YPL272C_p YPL272C YPL272C hom Uncharacterized 1.09888254317346 0.135909650978173 no 696 0.163083632010147 595 NA Putative protein of unknown function; gene expression induced in response to ketoconazole; YPL272C is not an essential gene biological_process molecular_function cellular_component
YLR146C YLR146C SPE4 hom Verified 1.09879260188162 0.135929269941321 no 697 0.122787712764355 472 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM Spermine synthase, required for the biosynthesis of spermine and also involved in biosynthesis of pantothenic acid pantothenate biosynthetic process|spermine biosynthetic process spermine synthase activity cytoplasm
YGR199W YGR199W PMT6 hom Verified 1.09859753948097 0.135971825715476 no 698 0.125845137605578 433 NA FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein O-mannosyltransferase, transfers mannose from dolichyl phosphate-D-mannose to protein serine/threonine residues of secretory proteins; reaction is essential for cell wall rigidity; member of a family of mannosyltransferases protein O-linked glycosylation|protein O-linked mannosylation dolichyl-phosphate-mannose-protein mannosyltransferase activity integral to membrane
YDL238C YDL238C GUD1 hom Verified 1.09668713864979 0.136389090295041 no 699 0.137524257657988 507 NA Guanine deaminase, a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine; activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures guanine metabolic process guanine deaminase activity|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides cytoplasm
YEL066W YEL066W HPA3 hom Verified 1.09596223535867 0.136547650730348 no 700 0.0893918459912639 333 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro D-amino acid metabolic process D-amino-acid N-acetyltransferase activity nucleus|cytoplasm
YBR296C-A_p YBR296C-A YBR296C-A hom Uncharacterized 1.09460436528259 0.136845001165236 no 701 0.151784808970007 560 NA Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YDL107W YDL107W MSS2 hom Verified 1.09445786380024 0.136877108928063 no 702 0.137454965615622 491 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Peripherally bound inner membrane protein of the mitochondrial matrix involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p protein insertion into mitochondrial membrane from inner side molecular_function extrinsic to mitochondrial inner membrane|mitochondrial matrix
YER153C YER153C PET122 hom Verified 1.09426959691575 0.13691837769785 no 703 0.130766222920976 502 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet494p; located in the mitochondrial inner membrane positive regulation of mitochondrial translation|mitochondrial respiratory chain complex IV biogenesis translation initiation factor activity mitochondrion|mitochondrial inner membrane|integral to mitochondrial inner membrane
YOR193W YOR193W PEX27 hom Verified 1.09313170342962 0.137167989004403 no 704 0.132204070216419 448 NA FT PEROXISOME ORGANIZATION Peripheral peroxisomal membrane protein involved in controlling peroxisome size and number, interacts with homologous protein Pex25p peroxisome organization molecular_function peroxisomal membrane
YKL064W YKL064W MNR2 hom Verified 1.09225464493185 0.137360594874841 no 705 0.128618824143465 454 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Vacuolar membrane protein required for magnesium homeostasis; putative magnesium transporter; has similarity to Alr1p and Alr2p, which mediate influx of Mg2+ and other divalent cations cellular magnesium ion homeostasis magnesium ion transmembrane transporter activity fungal-type vacuole membrane|integral to membrane
YGL115W YGL115W SNF4 hom Verified 1.09124553731543 0.137582427690464 no 706 0.156522016730521 585 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|PLASMA MEMBRANE Activating gamma subunit of the AMP-activated Snf1p kinase complex; additional subunits of the complex are Snf1p and a Sip1p/Sip2p/Gal83p family member; activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis; protein abundance increases in response to DNA replication stress positive regulation of gluconeogenesis|peroxisome organization|protein phosphorylation|replicative cell aging|regulation of transcription from RNA polymerase II promoter AMP-activated protein kinase activity|protein serine/threonine kinase activator activity AMP-activated protein kinase complex|plasma membrane|nucleus|nuclear envelope lumen|cytoplasm
YDR246W-A_p YDR246W-A YDR246W-A hom Uncharacterized 1.08856787911864 0.138172243965975 no 707 0.12348649310372 478 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YIL154C YIL154C IMP2' hom Verified 1.08713465968942 0.138488651115523 no 708 0.198610341635988 723 NA FF|FT RESPONSE TO DNA DAMAGE|ION HOMEOSTASIS|CARBOHYDRATE METABOLISM|ION HOMEOSTASIS Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeat DNA repair|cellular carbohydrate metabolic process transcription coactivator activity cytoplasm
YNL293W YNL293W MSB3 hom Verified 1.08656376540336 0.138614822972025 no 709 0.139484938456976 467 NA FT VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH Rab GTPase-activating protein; regulates endocytosis via activation of Vps21p and Ypt7p; also acts on Ypt52p and Sec4p; also required for proper actin organization; localizes to the plasma membrane and sites of polarized growth, and a portion localizes to endosomes and vacuoles; similar to Msb4p; relocalizes from bud neck to cytoplasm upon DNA replication stress actin filament organization|exocytosis Rab GTPase activator activity incipient cellular bud site|polarisome|cellular bud tip
YDR286C_p YDR286C YDR286C hom Uncharacterized 1.08590608514962 0.138760272216458 no 710 0.112427613555953 383 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site biological_process molecular_function cellular_component
YBR036C YBR036C CSG2 hom Verified 1.08537288472225 0.138878268403781 no 711 0.179184023364226 654 NA FF|FT LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Endoplasmic reticulum membrane protein, required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations; protein abundance increases in response to DNA replication stress cellular calcium ion homeostasis|glycosphingolipid biosynthetic process enzyme regulator activity integral to endoplasmic reticulum membrane|integral to membrane
YOR289W_p YOR289W YOR289W hom Uncharacterized 1.0842845869907 0.1391193185103 no 712 0.121963206372149 411 NA FT NUCLEUS Putative protein of unknown function; transcription induced by the unfolded protein response; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus biological_process molecular_function nucleus|cytoplasm
YHR130C_d YHR130C YHR130C hom Dubious 1.08415022928668 0.139149097510363 no 713 0.145111986340353 503 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR057W YLR057W MNL2 hom Verified 1.08294235114809 0.139417006060277 no 714 0.153747192677981 530 NA FT PROTEOLYSIS ENDOPLASMIC RETICULUM Putative mannosidase involved in ER-associated protein degradation; localizes to the endoplasmic reticulum; sequence similarity with seven-hairpin glycosidase (GH47) family members, such as Mns1p and Mnl1p, that hydrolyze 1,2-linked alpha-D-mannose residues; non-essential gene ER-associated protein catabolic process molecular_function endoplasmic reticulum
YPL263C YPL263C KEL3 hom Verified 1.08273317843819 0.139463436391161 no 715 0.110392218582886 433 NA Cytoplasmic protein of unknown function biological_process molecular_function cytoplasm
YMR152W YMR152W YIM1 hom Verified 1.08213617163449 0.13959601259008 no 716 0.138258878078852 516 NA FT RESPONSE TO DNA DAMAGE|OXIDATION-REDUCTION PROCESS MITOCHONDRION Protein of unknown function; null mutant displays sensitivity to DNA damaging agents; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress response to DNA damage stimulus molecular_function mitochondrion|lipid particle|cytoplasm
YBL079W YBL079W NUP170 hom Verified 1.08205083436548 0.139614970278452 no 717 0.164142693431004 589 NA FF|FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA LOCALIZATION|CHROMOSOME SEGREGATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication nucleocytoplasmic transport|chromosome segregation|protein targeting to nuclear inner membrane|mitotic cell cycle spindle assembly checkpoint|nuclear pore complex assembly structural constituent of nuclear pore integral to membrane|nuclear pore|nuclear pore inner ring
YLR209C YLR209C PNP1 hom Verified 1.08166090925392 0.139701614480642 no 718 0.150079824575371 492 NA FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM Purine nucleoside phosphorylase, specifically metabolizes inosine and guanosine nucleosides; involved in the nicotinamide riboside salvage pathway guanosine catabolic process|inosine catabolic process|NAD biosynthesis via nicotinamide riboside salvage pathway|nicotinate nucleotide salvage nicotinamide riboside hydrolase activity|inosine nucleosidase activity|purine-nucleoside phosphorylase activity intracellular
YBR270C_p YBR270C BIT2 hom Uncharacterized 1.08100846424357 0.139846674267085 no 719 0.118212708492241 432 NA Subunit of TORC2 membrane-associated complex; involved in regulation of actin cytoskeletal dynamics during polarized growth and cell wall integrity; interacts with Slm1p and Slm2p, homologous PH domain-containing TORC2 substrates; BIT2 has a paralog, BIT61, that arose from the whole genome duplication biological_process molecular_function cellular_component
YJL067W_d YJL067W YJL067W hom Dubious 1.08085910422068 0.139879896263411 no 720 0.120349889911 418 NA Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YKL071W_p YKL071W YKL071W hom Uncharacterized 1.07981441322951 0.140112415773695 no 721 0.145476786211069 490 NA FT OXIDATION-REDUCTION PROCESS Putative protein of unknown function; expression induced in cells treated with the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm biological_process molecular_function integral to membrane|cytoplasm
YKL201C YKL201C MNN4 hom Verified 1.07685893452346 0.140771645749337 no 722 0.135963156755539 463 NA FT CARBOHYDRATE METABOLISM Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication protein O-linked glycosylation|protein N-linked glycosylation|response to stress molecular_function membrane
YCR010C YCR010C ADY2 hom Verified 1.07667751427975 0.140812180623379 no 723 0.158942559028693 541 NA FT CELL CYCLE|ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION|PLASMA MEMBRANE Acetate transporter required for normal sporulation; phosphorylated in mitochondria; ADY2 has a paralog, ATO2, that arose from the whole genome duplication nitrogen utilization|ammonium transport|acetate transport|transmembrane transport acetate transmembrane transporter activity|ammonium transmembrane transporter activity mitochondrion|integral to membrane|plasma membrane
YBR168W YBR168W PEX32 hom Verified 1.07605943725567 0.140950337524732 no 724 0.155714839124784 535 NA FT PEROXISOME ORGANIZATION Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p peroxisome organization molecular_function integral to membrane|integral to peroxisomal membrane
YDL088C YDL088C ASM4 hom Verified 1.0760307106395 0.140956760934233 no 725 0.134019954486283 534 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE FG-nucleoporin component of central core of nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport; induces membrane tubulation, which may contribute to nuclear pore assembly; ASM4 has a paralog, NUP53, that arose from the whole genome duplication nuclear pore organization|mRNA export from nucleus in response to heat stress|mitotic cell cycle spindle assembly checkpoint nucleocytoplasmic transporter activity|phospholipid binding|single-stranded DNA binding nuclear pore central transport channel|integral to membrane|nuclear pore
YDR219C YDR219C MFB1 hom Verified 1.07481836680824 0.141228027865601 no 726 0.118857912121729 430 NA FT PROTEOLYSIS|MITOCHONDRION ORGANIZATION MITOCHONDRION UBIQUITIN LIGASE COMPLEX Mitochondria-associated F-box protein involved in maintenance of normal mitochondrial morphology; interacts with Skp1p through the F-box motif; preferentially localizes to the mother cell during budding SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|mitochondrion organization molecular_function extrinsic to mitochondrial outer membrane|SCF ubiquitin ligase complex
YNL071W YNL071W LAT1 hom Verified 1.07481633538461 0.141228482701831 no 727 0.159487886986737 563 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA acetyl-CoA biosynthetic process from pyruvate dihydrolipoyllysine-residue acetyltransferase activity mitochondrion|mitochondrial pyruvate dehydrogenase complex
YOR253W YOR253W NAT5 hom Verified 1.07373410305855 0.14147093597563 no 728 0.139182236991859 481 NA FT RIBOSOME Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing N-terminal protein amino acid acetylation peptide alpha-N-acetyltransferase activity NatA complex|cytosolic ribosome
YHR049C-A_d YHR049C-A YHR049C-A hom Dubious 1.07345648409857 0.141533176578499 no 729 0.12654646915525 466 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YML082W_p YML082W YML082W hom Uncharacterized 1.07338522863823 0.141549154642027 no 730 0.171358307669714 573 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Putative protein predicted to have carbon-sulfur lyase activity; transcriptionally regulated by Upc2p via an upstream sterol response element; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and the cytoplasm; YML082W is not an essential gene sulfur compound metabolic process carbon-sulfur lyase activity nucleus|cytoplasm
YDR193W_d YDR193W YDR193W hom Dubious 1.07325457448039 0.141578455226892 no 731 0.10923783512777 387 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YER047C YER047C SAP1 hom Verified 1.07322951823068 0.141584074827008 no 732 0.156569736577622 575 NA Putative ATPase of the AAA family, interacts with the Sin1p transcriptional repressor in the two-hybrid system biological_process ATPase activity cytoplasm
YGL192W YGL192W IME4 hom Verified 1.07146480576761 0.141980243599643 no 733 0.16672101634207 576 NA FT CELL CYCLE NUCLEUS Probable mRNA N6-adenosine methyltransferase required for entry into meiosis; transcribed in diploid cells; haploids repress IME4 transcription via production of antisense IME4 transcripts; antisense transcription is repressed in diploids meiosis|mRNA methylation mRNA (N6-adenosine)-methyltransferase activity cellular_component
YGR266W YGR266W YGR266W hom Verified 1.07135152115112 0.142005701016332 no 734 0.135882348339102 484 NA FT MITOCHONDRION|PLASMA MEMBRANE Protein of unknown function; predicted to contain a single transmembrane domain; mutant has increased aneuploidy tolerance; localized to both the mitochondrial outer membrane and the plasma membrane; protein abundance increases in response to DNA replication stress biological_process molecular_function mitochondrial outer membrane|mitochondrion|plasma membrane
YDL204W YDL204W RTN2 hom Verified 1.07084550568819 0.142119450973764 no 735 0.166491391010329 577 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Reticulon protein; stabilizes membrane curvature; involved in nuclear pore assembly and maintenance of tubular ER morphology; interacts with exocyst subunit Sec6p, Yip3p, and Sbh1p; much less abundant than Rtn1p; rtn1 rtn2 yop1 triple mutant lacks tubular ER; member of RTNLA (reticulon-like A) subfamily; protein increases in abundance and relocalizes to plasma membrane upon DNA replication stress; RTN2 has a paralog, RTN1, that arose from the whole genome duplication endoplasmic reticulum tubular network organization|endoplasmic reticulum tubular network maintenance molecular_function endoplasmic reticulum|cortical endoplasmic reticulum|endoplasmic reticulum tubular network
YMR259C YMR259C TRM732 hom Verified 1.06807525820874 0.142743282721164 no 736 0.153756105640975 561 NA Interacts with Trm7p for 2'-O-methylation of C32 of substrate tRNAs; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; non-essential gene biological_process molecular_function cytoplasm
YJL192C YJL192C SOP4 hom Verified 1.0655643169851 0.143310318398536 no 737 0.201494437631061 693 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM ER-membrane protein; suppressor of pma1-7, deletion of SOP4 slows down the export of wild-type Pma1p and Pma1-7 from the ER ER to Golgi vesicle-mediated transport molecular_function integral to membrane|endoplasmic reticulum
YGR051C_d YGR051C YGR051C hom Dubious 1.06469074617193 0.143507949533084 no 738 0.130106967560203 490 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene Unknown Unknown Unknown
YFL050C YFL050C ALR2 hom Verified 1.06463189137702 0.143521271081585 no 739 0.155141901790839 539 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Probable Mg(2+) transporter; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; plays a role in regulating Ty1 transposition magnesium ion transport|cation transport|transmembrane transport inorganic cation transmembrane transporter activity integral to membrane|plasma membrane
YGL013C YGL013C PDR1 hom Verified 1.06441530267222 0.143570302260897 no 740 0.267855640198127 953 NA FF|FT TRANSCRIPTION FROM RNA POL II NUCLEUS RSC COMPLEX Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication Unknown|positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YMR115W YMR115W MGR3 hom Verified 1.06327712249143 0.143828148394374 no 741 0.136154502164625 486 NA FT PROTEOLYSIS MITOCHONDRION Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA misfolded or incompletely synthesized protein catabolic process misfolded protein binding mitochondrion|mitochondrial inner membrane|i-AAA complex
YPR062W YPR062W FCY1 hom Verified 1.05915718920849 0.144764099164291 no 742 0.164376801560832 603 NA FT NUCLEUS Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU) cytosine metabolic process|pyrimidine-containing compound salvage|cytidine metabolic process cytosine deaminase activity nucleus|cytoplasm
YIL071C YIL071C PCI8 hom Verified 1.0554211348865 0.145616380508598 no 743 0.158254256024086 560 NA FT NUCLEUS Possible shared subunit of Cop9 signalosome (CSN) and eIF3, binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain cullin deneddylation molecular_function signalosome
YLR102C YLR102C APC9 hom Verified 1.05501598306074 0.145709007468158 no 744 0.13241599370013 472 NA FT CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION NUCLEUS UBIQUITIN LIGASE COMPLEX Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition chromatin assembly|protein ubiquitination ubiquitin-protein ligase activity anaphase-promoting complex
YPL101W YPL101W ELP4 hom Verified 1.05248666435826 0.146288162863911 no 745 0.177852465530186 605 NA FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity regulation of transcription from RNA polymerase II promoter|tRNA wobble uridine modification ATPase activity|tRNA binding Elongator holoenzyme complex|cytoplasm
YER128W YER128W VFA1 hom Verified 1.05236241543628 0.146316652767072 no 746 0.150082799100905 556 NA FT VACUOLAR TRANSPORT Protein that interacts with Vps4p and has a role in vacuolar sorting; localizes to endosomes in a Vps4-dependent manner; overexpression causes canavanine sensitivity and confers a partial class D vacuole morphology vacuolar transport molecular_function endosome|cytoplasm
YMR110C YMR110C HFD1 hom Verified 1.05198507304557 0.146403199077113 no 747 0.120925493502439 447 NA FT OXIDATION-REDUCTION PROCESS MITOCHONDRION Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder cellular aldehyde metabolic process 3-chloroallyl aldehyde dehydrogenase activity mitochondrial outer membrane|endosome|mitochondrion|lipid particle|integral to mitochondrial outer membrane
YGL244W YGL244W RTF1 hom Verified 1.05143979436904 0.146528323539817 no 748 0.212167741099673 734 NA FF|FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|GENE SILENCING NUCLEUS|CHROMOSOME RNA POL II, HOLOENZYME Subunit of RNAPII-associated chromatin remodeling Paf1 complex; regulates gene expression by directing cotranscriptional histone modification, influences transcription and chromatin structure through several independent functional domains; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay mRNA 3'-end processing|snoRNA transcription from an RNA polymerase II promoter|regulation of chromatin silencing at telomere|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of histone H3-K4 methylation|regulation of transcription-coupled nucleotide-excision repair|negative regulation of transcription from RNA polymerase II promoter|recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex|global genome nucleotide-excision repair|snoRNA 3'-end processing|Unknown|transcription elongation from RNA polymerase II promoter RNA binding|RNA polymerase II transcription factor binding transcription factor activity nucleus|transcriptionally active chromatin|Cdc73/Paf1 complex
YOL098C_p YOL098C YOL098C hom Uncharacterized 1.05045664558626 0.146754106877133 no 749 0.147868479798978 571 NA FT PROTEOLYSIS Putative metalloprotease biological_process molecular_function cytoplasm
YCL022C_d YCL022C YCL022C hom Dubious 1.04957284777358 0.146957273065045 no 750 0.109330481443 368 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene KCC4/YCL024W Unknown Unknown Unknown
YNR004W_p YNR004W SWM2 hom Uncharacterized 1.04663319826573 0.147634392155847 no 751 0.140019156529052 515 NA FT NUCLEUS Putative protein of unknown function; haploid disruptant exhibits cold-sensitive growth and elongated buds biological_process molecular_function nucleolus
YKR033C_d YKR033C YKR033C hom Dubious 1.04634315219137 0.147701314473196 no 752 0.147948308050114 484 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene DAL80 Unknown Unknown Unknown
YOR315W YOR315W SFG1 hom Verified 1.04609790923585 0.147757915217873 no 753 0.139808107878354 477 NA FT CELL CYCLE NUCLEUS Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate mitotic cell cycle|pseudohyphal growth molecular_function nucleus|cytoplasm
YBR214W YBR214W SDS24 hom Verified 1.0432613559611 0.148413631821208 no 754 0.147657056507787 506 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL DIVISION Protein involved in cell separation during budding; one of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; may play an indirect role in fluid-phase endocytosis; protein abundance increases in response to DNA replication stress; SDS24 has a paralog, SDS23, that arose from the whole genome duplication endocytosis|cytokinetic cell separation molecular_function cytoplasm
YMR105C YMR105C PGM2 hom Verified 1.04086772247985 0.148968471947133 no 755 0.125268329913186 438 NA FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY Phosphoglucomutase; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase; protein abundance increases in response to DNA replication stress glucose 6-phosphate metabolic process|cellular calcium ion homeostasis|galactose catabolic process|cellular cation homeostasis|glucose 1-phosphate metabolic process|trehalose biosynthetic process|UDP-glucose metabolic process|glycogen biosynthetic process phosphoglucomutase activity cytoplasm
YDL101C YDL101C DUN1 hom Verified 1.04025809179448 0.149110004426404 no 756 0.162993080520481 605 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION NUCLEUS Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; also regulates postreplicative DNA repair protein phosphorylation|replication fork protection|cell cycle checkpoint|DNA damage checkpoint protein kinase activity nucleus
YMR232W YMR232W FUS2 hom Verified 1.0388988637641 0.149425887447968 no 757 0.10817376915595 437 NA FT SIGNALING NUCLEUS|MITOCHONDRION|SITE OF POLARIZED GROWTH Cytoplasmic protein localized to the shmoo tip; required for the alignment of parental nuclei before nuclear fusion during mating karyogamy involved in conjugation with cellular fusion|regulation of termination of mating projection growth|cytogamy molecular_function mitochondrion|nucleus|mating projection tip|cytoplasm
YMR032W YMR032W HOF1 hom Verified 1.03872129290652 0.1494671876753 no 758 0.153312542314266 612 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION SITE OF POLARIZED GROWTH|CYTOSKELETON Bud neck-localized, SH3 domain-containing protein required for cytokinesis; is phosphorylated by Dbf2p; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p cytokinesis after mitosis|barrier septum assembly involved in cell cycle cytokinesis|response to DNA damage stimulus|cytokinesis cytoskeletal protein binding cellular bud neck contractile ring|cellular bud neck septin ring
YGL226C-A YGL226C-A OST5 hom Verified 1.03799273376851 0.149636718984546 no 759 0.146194734890151 532 NA FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Zeta subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins protein N-linked glycosylation dolichyl-diphosphooligosaccharide-protein glycotransferase activity oligosaccharyltransferase complex
YLR346C_p YLR346C YLR346C hom Uncharacterized 1.03769015460022 0.149707165022105 no 760 0.119050289049464 425 NA FT MITOCHONDRION Putative protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; YLR346C is not an essential gene biological_process molecular_function mitochondrion
YPR015C_p YPR015C YPR015C hom Uncharacterized 1.03639514583968 0.150008917020271 no 761 0.158988721128941 517 NA Putative protein of unknown function; overexpression causes a cell cycle delay or arrest biological_process sequence-specific DNA binding cellular_component
YIL128W YIL128W MET18 hom Verified 1.03511127814513 0.150308473071992 no 762 0.257014310066674 845 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|RESPONSE TO DNA DAMAGE NUCLEUS Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Cia2p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human MMS19 methionine metabolic process|nucleotide-excision repair|transcription from RNA polymerase II promoter molecular_function cytoplasm
YPL005W YPL005W AEP3 hom Verified 1.03503515769901 0.150326246243236 no 763 0.153587222628779 539 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Protein that may facilitate use of unformylated tRNA-Met in mitochondrial translation initiation; localized to the matrix face of the mitochondrial inner membrane; stabilizes the bicistronic AAP1-ATP6 mRNA mRNA metabolic process|mitochondrial translational initiation molecular_function mitochondrion|mitochondrial inner membrane|cytoplasm|extrinsic to membrane
YBR014C YBR014C GRX7 hom Verified 1.03411253482759 0.150541778484244 no 764 0.132701762977549 535 NA FT RESPONSE TO OXIDATIVE STRESS GOLGI APPARATUS Cis-golgi localized monothiol glutaredoxin; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; does not bind metal ions; GRX7 has a paralog, GRX6, that arose from the whole genome duplication cellular response to oxidative stress glutathione-disulfide reductase activity|protein homodimerization activity integral to membrane|Golgi apparatus|Golgi lumen|fungal-type vacuole|cis-Golgi network
YEL012W YEL012W UBC8 hom Verified 1.03309373629259 0.150780017170362 no 765 0.14836970176027 527 NA FT KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein polyubiquitination|protein monoubiquitination ubiquitin-protein ligase activity cytoplasm
YKL123W_d YKL123W YKL123W hom Dubious 1.03203190471388 0.151028585824407 no 766 0.162692044360472 538 NA Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene SSH4 Unknown Unknown Unknown
YLR082C YLR082C SRL2 hom Verified 1.03040562021082 0.151409818029507 no 767 0.150333556577867 467 NA FT NUCLEUS Protein of unknown function; overexpression suppresses the lethality caused by a rad53 null mutation nucleobase-containing compound metabolic process molecular_function nucleus|cytoplasm
YGL096W YGL096W TOS8 hom Verified 1.02953565285769 0.151614017517524 no 768 0.131586932441573 426 NA FT NUCLEUS|CHROMOSOME Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication biological_process chromatin binding|sequence-specific DNA binding nuclear chromatin
YJL141C YJL141C YAK1 hom Verified 1.02836925958839 0.151888081469983 no 769 0.136729339159507 512 NA FT PROTEIN PHOSPHORYLATION NUCLEUS Serine-threonine protein kinase; component of a glucose-sensing system that inhibits growth in response to glucose availability; upon nutrient deprivation Yak1p phosphorylates Pop2p to regulate mRNA deadenylation, the co-repressor Crf1p to inhibit transcription of ribosomal genes, and the stress-responsive transcription factors Hsf1p and Msn2p; nuclear localization negatively regulated by the Ras/PKA signaling pathway in the presence of glucose protein phosphorylation protein serine/threonine kinase activity|protein tyrosine kinase activity|protein kinase activity nucleus|cytoplasm
YKR098C YKR098C UBP11 hom Verified 1.02726054668517 0.152148897373255 no 770 0.152892788841751 558 NA FT PROTEOLYSIS Ubiquitin-specific protease that cleaves ubiquitin from ubiquitinated proteins biological_process ubiquitin-specific protease activity cellular_component
YDR507C YDR507C GIN4 hom Verified 1.02585712826164 0.152479466639773 no 771 0.157710636175094 602 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION SITE OF POLARIZED GROWTH Protein kinase involved in bud growth and assembly of the septin ring; proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Hsl1p; GIN4 has a paralog, KCC4, that arose from the whole genome duplication protein autophosphorylation|budding cell bud growth|protein phosphorylation|septin checkpoint|septin ring assembly protein kinase activity cellular bud neck
YJL142C_d YJL142C IRC9 hom Dubious 1.02557022408248 0.152547104337326 no 772 0.127997646856289 443 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene YJL141C; null mutant displays increased levels of spontaneous Rad52p foci Unknown Unknown Unknown
YBR138C_p YBR138C YBR138C hom Uncharacterized 1.02515891049792 0.152644106291292 no 773 0.114094412889118 451 NA Cytoplasmic protein of unknown function, potentially phosphorylated by Cdc28p; YBR138C is not an essential gene biological_process molecular_function cytoplasm
YDL010W YDL010W GRX6 hom Verified 1.02462249360042 0.152770673396618 no 774 0.148344115319277 488 NA FT RESPONSE TO OXIDATIVE STRESS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Cis-golgi localized monothiol glutaredoxin, binds Fe-S cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; GRX6 has a paralog, GRX7, that arose from the whole genome duplication cellular response to oxidative stress glutathione-disulfide reductase activity|iron ion binding|protein homodimerization activity|2 iron, 2 sulfur cluster binding integral to membrane|Golgi apparatus|Golgi lumen|endoplasmic reticulum membrane|fungal-type vacuole|cis-Golgi network
YNL199C YNL199C GCR2 hom Verified 1.02357065890734 0.153019054882898 no 775 0.170911454573078 608 NA FT TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY ENDOMEMBRANE SYSTEM|NUCLEUS Transcriptional activator of genes involved in glycolysis; interacts and functions with the DNA-binding protein Gcr1p positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter|regulation of glycolysis by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II activating transcription factor binding|RNA polymerase II transcription factor binding transcription factor activity nuclear envelope|nucleus
YJL189W YJL189W RPL39 hom Verified 1.02246733162732 0.153279883415995 no 776 0.155785219708097 542 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YBR009C YBR009C HHF1 hom Verified 1.02060256541813 0.15372138676909 no 777 0.139316438078239 517 NA FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Histone H4, core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity chromatin assembly or disassembly|sexual sporulation resulting in formation of a cellular spore|histone H3-K79 methylation DNA binding replication fork protection complex|nuclear nucleosome
YKL185W YKL185W ASH1 hom Verified 1.02051648462631 0.153741787625683 no 778 0.111143007659971 417 NA FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate Unknown RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|core promoter proximal region sequence-specific DNA binding Rpd3L-Expanded complex|nucleus|cellular bud|Rpd3L complex
YML070W YML070W DAK1 hom Verified 1.01853166578838 0.154212680076974 no 779 0.111094666601715 368 NA FT CARBOHYDRATE METABOLISM Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation response to stress|glycerol catabolic process glycerone kinase activity cytoplasm
YNL204C YNL204C SPS18 hom Verified 1.01780653667832 0.154384952491635 no 780 0.168075212241607 604 NA FT SIGNALING|NUCLEOTIDE METABOLISM Protein of unknown function, contains a putative zinc-binding domain; expressed during sporulation sporulation resulting in formation of a cellular spore molecular_function cellular_component
YLR357W YLR357W RSC2 hom Verified 1.0172697106212 0.154512570778769 no 781 0.160026958659702 555 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS RSC COMPLEX Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenance ATP-dependent chromatin remodeling|chromosome segregation|nucleosome disassembly|plasmid maintenance|sister chromatid cohesion|double-strand break repair via nonhomologous end joining|transcription elongation from RNA polymerase II promoter|double-strand break repair via homologous recombination DNA translocase activity RSC complex
YJL106W YJL106W IME2 hom Verified 1.01510103454474 0.155028834268827 no 782 0.145779780712806 487 NA FT CELL CYCLE|PROTEIN PHOSPHORYLATION NUCLEUS Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p protein phosphorylation|regulation of meiosis protein kinase activity nucleus
YOL079W_d YOL079W YOL079W hom Dubious 1.01499034430092 0.155055215116901 no 783 0.174792733818785 543 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOL028C YOL028C YAP7 hom Verified 1.01405878138339 0.155277352305044 no 784 0.161919080445383 581 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Putative basic leucine zipper (bZIP) transcription factor; YAP7 has a paralog, YAP5, that arose from the whole genome duplication positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding nucleus
YLR216C YLR216C CPR6 hom Verified 1.01219350256694 0.155722771121973 no 785 0.121876549674566 415 NA Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity; protein abundance increases in response to DNA replication stress protein folding|protein refolding unfolded protein binding|peptidyl-prolyl cis-trans isomerase activity cytoplasm
YPR192W YPR192W AQY1 hom Verified 1.01190157684488 0.155792557633674 no 786 0.131224042820146 463 NA FT PLASMA MEMBRANE Spore-specific water channel that mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance ascospore formation|water transport water channel activity integral to membrane|plasma membrane
YML095C YML095C RAD10 hom Verified 1.01074570205216 0.156069078545556 no 787 0.137230157213407 488 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS Single-stranded DNA endonuclease (with Rad1p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein mitotic recombination|meiotic mismatch repair|DNA strand renaturation|nucleotide-excision repair, DNA incision, 5'-to lesion|removal of nonhomologous ends|double-strand break repair via single-strand annealing, removal of nonhomologous ends single-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity nucleotide-excision repair factor 1 complex|nucleus
YML048W YML048W GSF2 hom Verified 1.01044799678319 0.156140351179468 no 788 0.192398383724275 692 NA FF|FT PROTEIN LOCALIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression protein folding|protein localization to cell surface unfolded protein binding mitochondrial outer membrane|integral to endoplasmic reticulum membrane|cytoplasm
YER114C YER114C BOI2 hom Verified 1.00933798505889 0.156406284445556 no 789 0.18984669798117 634 NA FT SIGNALING|CELL DIVISION SITE OF POLARIZED GROWTH|CYTOSKELETON Protein implicated in polar growth, functionally redundant with Boi1p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; BOI2 has a paralog, BOI1, that arose from the whole genome duplication cytokinesis, completion of separation|establishment of cell polarity|budding cell apical bud growth|Rho protein signal transduction phospholipid binding site of polarized growth|cellular bud|cellular bud neck
YBR052C YBR052C RFS1 hom Verified 1.00717697462276 0.156924867959468 no 790 0.111827132684482 443 NA FT OXIDATION-REDUCTION PROCESS Protein of unknown function; member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; RFS1 has a paralog, PST2, that arose from the whole genome duplication biological_process molecular_function membrane raft|cytoplasm
YER163C YER163C GCG1 hom Verified 1.0067219572245 0.157034203718924 no 791 0.15424969099271 578 NA FT NUCLEUS Gamma-glutamyl cyclotransferase; cleaves the gamma-glutamyl bond of glutathione to yield 5-oxoproline and a Cys-Gly dipeptide; similar to mammalian pro-apoptotic protein ChaC1; expression of mouse ChaC1 in yeast increases apoptosis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; periodically expressed during the metabolic cycle biological_process molecular_function nucleus|cytoplasm
YPL215W YPL215W CBP3 hom Verified 1.00654085098342 0.157077735527446 no 792 0.130372927417151 485 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex positive regulation of mitochondrial translation|mitochondrial respiratory chain complex III assembly ribosome binding integral to mitochondrial membrane|mitochondrion|mitochondrial ribosome
YNL196C_p YNL196C SLZ1 hom Uncharacterized 1.00583185347518 0.157248230871953 no 793 0.167410829753077 622 NA Sporulation-specific protein with a leucine zipper motif biological_process molecular_function cellular_component
YJR087W_d YJR087W YJR087W hom Dubious 1.0028713306059 0.157961473451636 no 794 0.149976849594272 550 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified genes STE18 and ECM2 Unknown Unknown Unknown
YDR003W YDR003W RCR2 hom Verified 1.00185164091212 0.15820762584544 no 795 0.136127033683054 478 NA FT VESICLE-MEDIATED TRANSPORT Vacuolar protein; presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR2 has a paralog, RCR1, that arose from the whole genome duplication vesicle-mediated transport molecular_function vesicle|integral to membrane|fungal-type vacuole|cytoplasm
YIL043C YIL043C CBR1 hom Verified 1.0014806178807 0.158297252977687 no 796 0.16986616040227 585 NA FT OXIDATION-REDUCTION PROCESS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION Microsomal cytochrome b reductase, not essential for viability; also detected in mitochondria; mutation in conserved NADH binding domain of the human ortholog results in type I methemoglobinemia biological_process cytochrome-b5 reductase activity mitochondrial outer membrane|mitochondrion
YBL031W YBL031W SHE1 hom Verified 1.00021557253181 0.158603097312122 no 797 0.154351865488122 579 NA FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON Mitotic spindle protein; interacts with components of the Dam1 (DASH) complex, its effector Sli15p, and microtubule-associated protein Bim1p; also localizes to nuclear microtubules and to the bud neck in a ring-shaped structure; inhibits dynein function mitotic spindle elongation molecular_function microtubule cytoskeleton|nuclear microtubule|cellular bud neck|astral microtubule|spindle
YML051W YML051W GAL80 hom Verified 0.999646393439974 0.1587408314947 no 798 0.16402728417601 528 NA FT TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM NUCLEUS Transcriptional regulator involved in the repression of GAL genes in the absence of galactose; inhibits transcriptional activation by Gal4p; inhibition relieved by Gal3p or Gal1p binding negative regulation of kinase activity|galactose metabolic process|negative regulation of transcription from RNA polymerase II promoter|negative regulation of sequence-specific DNA binding transcription factor activity RNA polymerase II activating transcription factor binding|kinase inhibitor activity nucleus|cytoplasm
YGR228W_d YGR228W YGR228W hom Dubious 0.998705970017664 0.15896857389541 no 799 0.189942744414953 693 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SMI1/YGR229C Unknown Unknown Unknown
YGL223C YGL223C COG1 hom Verified 0.997591861834894 0.159238654477105 no 800 0.218040141519713 713 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments retrograde transport, vesicle recycling within Golgi|intra-Golgi vesicle-mediated transport|CVT pathway molecular_function Golgi transport complex
YKR036C YKR036C CAF4 hom Verified 0.996886129641299 0.159409892493205 no 801 0.14836479277626 528 NA FT TRANSCRIPTION FROM RNA POL II|MITOCHONDRION ORGANIZATION|PEROXISOME ORGANIZATION NUCLEUS|MITOCHONDRION WD40 repeat-containing protein associated with the CCR4-NOT complex; interacts in a Ccr4p-dependent manner with Ssn2p; also interacts with Fis1p, Mdv1p and Dnm1p and plays a role in mitochondrial fission; CAF4 has a paralog, MDV1, that arose from the whole genome duplication peroxisome fission|mitochondrial fission|regulation of transcription from RNA polymerase II promoter molecular_function mitochondrion|CCR4-NOT complex
YNL159C YNL159C ASI2 hom Verified 0.996523141150927 0.159498014520562 no 802 0.127605415412462 485 NA FT PROTEOLYSIS ENDOMEMBRANE SYSTEM|NUCLEUS Integral inner nuclear membrane protein that acts with Asi1p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals ubiquitin-dependent protein catabolic process molecular_function nuclear inner membrane
YOR213C YOR213C SAS5 hom Verified 0.995012161708938 0.1598651747021 no 803 0.181595691217252 641 NA FT CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME HISTONE ACETYLTRANSFERASE Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity chromatin silencing at telomere acetyltransferase activity|histone acetyltransferase activity nuclear chromatin|SAS acetyltransferase complex|nuclear chromosome, telomeric region
YKL217W YKL217W JEN1 hom Verified 0.994529957963246 0.159982463994733 no 804 0.154134132118212 546 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION|PLASMA MEMBRANE Monocarboxylate/proton symporter of the plasma membrane; transport activity is dependent on the pH gradient across the membrane; mediates high-affinity uptake of carbon sources lactate, pyuvate, and acetate, and also of the micronutrient selenite, whose structure mimics that of monocarboxylates; expression and localization are tightly regulated, with transcription repression, mRNA degradation, and protein endocytosis and degradation all occurring in the presence of glucose plasma membrane lactate transport|plasma membrane selenite transport|plasma membrane pyruvate transport selenite:hydrogen symporter activity|secondary active monocarboxylate transmembrane transporter activity mitochondrion|integral to membrane|plasma membrane
YGR261C YGR261C APL6 hom Verified 0.993990995686741 0.160113625587985 no 805 0.191055355646927 671 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools vesicle-mediated transport|Golgi to vacuole transport molecular_function AP-3 adaptor complex
YER123W YER123W YCK3 hom Verified 0.992985291282793 0.160358561255638 no 806 0.199152549199602 700 NA FT VESICLE-MEDIATED TRANSPORT|PROTEIN PHOSPHORYLATION ENDOMEMBRANE SYSTEM|NUCLEUS|PLASMA MEMBRANE Palmitoylated, vacuolar membrane-localized casein kinase I isoform; negatively regulates vacuole fusion during hypertonic stress via phosphorylation of Vps41p; shares essential functions with Hrr25p; regulates vesicle fusion in AP-3 pathway vesicle-mediated transport|protein phosphorylation protein serine/threonine kinase activity|protein kinase activity fungal-type vacuole membrane|plasma membrane|nucleus|fungal-type vacuole
YMR018W_p YMR018W YMR018W hom Uncharacterized 0.992957702193593 0.16036528392731 no 807 0.178669636993562 604 NA FT PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION Putative protein of unknown function with similarity to human PEX5Rp (peroxin protein 5 related protein); transcription increases during colony development similar to genes involved in peroxisome biogenesis; YMR018W is not an essential gene biological_process molecular_function cellular_component
YOL029C_p YOL029C YOL029C hom Uncharacterized 0.992689400805134 0.160430670903447 no 808 0.149985759868174 542 NA Putative protein of unknown function; identified as interacting with Hsc82p and Hsp82p in high-throughput two-hybrid screens biological_process molecular_function cellular_component
YCL026C-A YCL026C-A FRM2 hom Verified 0.992241783330432 0.160539797266793 no 809 0.136790902460521 510 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS NUCLEUS Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin cellular response to oxidative stress|negative regulation of fatty acid metabolic process oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor nucleus|cytoplasm
YDR391C_p YDR391C YDR391C hom Uncharacterized 0.991101744666651 0.160817950588488 no 810 0.159588016829986 527 NA FT NUCLEUS Putative protein of unknown function, possibly involved in zinc homeostasis; Bdf1p-dependent transcription induced by salt stress; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus biological_process molecular_function nucleus|cytoplasm
YNL143C_p YNL143C YNL143C hom Uncharacterized 0.990958560161719 0.160852907811984 no 811 0.179867658509847 568 NA Protein of unknown function; expressed at both mRNA and protein levels biological_process molecular_function cellular_component
YMR121C YMR121C RPL15B hom Verified 0.988839171836791 0.161370917725759 no 812 0.1383052696967 505 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress cytoplasmic translation structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YNR019W YNR019W ARE2 hom Verified 0.987904946664509 0.161599601304352 no 813 0.163275605592865 527 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen; ARE2 has a paralog, ARE1, that arose from the whole genome duplication ergosterol metabolic process ergosterol O-acyltransferase activity integral to membrane|endoplasmic reticulum
YKL096C-B_p YKL096C-B YKL096C-B hom Uncharacterized 0.987383928567355 0.161727230030933 no 814 0.179330309541646 578 NA Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YER087C-B YER087C-B SBH1 hom Verified 0.987265047685588 0.16175636032432 no 815 0.203147695951697 718 NA FT PROTEIN LOCALIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Beta subunit of the Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p); involved in protein translocation into the endoplasmic reticulum; interacts with the exocyst complex and also with Rtn1p; homologous to Sbh2p posttranslational protein targeting to membrane, translocation|SRP-dependent cotranslational protein targeting to membrane, translocation ARF guanyl-nucleotide exchange factor activity|P-P-bond-hydrolysis-driven protein transmembrane transporter activity Sec61 translocon complex
YBL054W YBL054W TOD6 hom Verified 0.986879538642869 0.161850848080372 no 816 0.157738563093603 547 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS|CHROMOSOME PAC motif binding protein involved in rRNA and ribosome biogenesis; subunit of the RPD3L histone deacetylase complex; Myb-like HTH transcription factor; hypophosphorylated by rapamycin treatment in a Sch9p-dependent manner; TOD6 has a paralog, DOT6, that arose from the whole genome duplication regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding Rpd3L-Expanded complex|nucleus|Rpd3L complex|cytoplasm
YHR063C YHR063C PAN5 hom Verified 0.985588612119622 0.162167514246032 no 817 0.177359458321911 611 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM 2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panE pantothenate biosynthetic process 2-dehydropantoate 2-reductase activity cytoplasm
YGR260W YGR260W TNA1 hom Verified 0.984322437779332 0.162478500301829 no 818 0.179851942643777 596 NA FT MITOCHONDRION|PLASMA MEMBRANE High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA) nicotinamide mononucleotide transport nicotinamide mononucleotide transmembrane transporter activity mitochondrion|integral to membrane|integral to plasma membrane
YIL052C YIL052C RPL34B hom Verified 0.98423437409788 0.162500144115744 no 819 0.201275834104502 725 NA FF|FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YBR025C YBR025C OLA1 hom Verified 0.981628548919557 0.163141438750132 no 820 0.166085421428086 580 NA P-loop ATPase with similarity to human OLA1 and bacterial YchF; identified as specifically interacting with the proteasome; protein abundance increases in response to hydrogen peroxide and to DNA replication stress biological_process ATPase activity cytoplasm
YPL269W YPL269W KAR9 hom Verified 0.981476666086463 0.163178867835836 no 821 0.20886922300405 728 NA FT NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase nuclear migration along microtubule|establishment of spindle localization molecular_function cell cortex|spindle pole body|mating projection tip
YJL213W YJL213W YJL213W hom Verified 0.980379674515399 0.163449369487403 no 822 0.149347419934386 485 NA Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p biological_process molecular_function ribosome
YCR087C-A_p YCR087C-A YCR087C-A hom Uncharacterized 0.97847818601371 0.163918937535877 no 823 0.176798988127184 635 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YCR087C-A is not an essential gene biological_process molecular_function nucleolus
YMR054W YMR054W STV1 hom Verified 0.978227403055276 0.163980933062365 no 824 0.166848153410345 616 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Subunit a of the vacuolar-ATPase V0 domain, one of two isoforms (Stv1p and Vph1p); Stv1p is located in V-ATPase complexes of the Golgi and endosomes while Vph1p is located in V-ATPase complexes of the vacuole vacuolar acidification proton-transporting ATPase activity, rotational mechanism vacuolar proton-transporting V-type ATPase, V0 domain|late endosome|integral to membrane|Golgi apparatus
YNL321W YNL321W VNX1 hom Verified 0.976576967629673 0.164389313167996 no 825 0.178015189897892 610 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Calcium/H+ antiporter localized to the endoplasmic reticulum membrane; member of the calcium exchanger (CAX) family; potential Cdc28p substrate potassium ion transport|sodium ion transport|hydrogen transport potassium:hydrogen antiporter activity|sodium:hydrogen antiporter activity|calcium:hydrogen antiporter activity fungal-type vacuole membrane|integral to membrane|endoplasmic reticulum membrane|fungal-type vacuole
YCR065W YCR065W HCM1 hom Verified 0.976283527008134 0.164461990443735 no 826 0.165901663467798 621 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|RESPONSE TO OXIDATIVE STRESS NUCLEUS|CHROMOSOME Forkhead transcription factor that drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere maintenance role positive regulation of transcription involved in S-phase of mitotic cell cycle|cellular response to oxidative stress|mitochondrion organization|spindle pole body organization|positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding nuclear chromatin|nucleus|cytoplasm
YEL020C_p YEL020C YEL020C hom Uncharacterized 0.976251072150962 0.164470029909713 no 827 0.172785230827751 576 NA Protein of unknown function with low sequence identity to Pdc1p; mRNA identified as translated by ribosome profiling data biological_process molecular_function cytoplasm
YBR086C YBR086C IST2 hom Verified 0.975790321553173 0.164584190958487 no 828 0.178119342071297 593 NA FT PLASMA MEMBRANE Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localizes to the mother cell in small-budded cells and to the bud in medium- and large-budded cells; mRNA is transported to the bud tip by an actomyosin-driven process response to osmotic stress lipid binding integral to membrane|cellular bud membrane|plasma membrane
YJL151C YJL151C SNA3 hom Verified 0.974208612731591 0.164976484564913 no 829 0.154882455533484 525 NA FT VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM Protein involved in efficient MVB sorting of proteins to the vacuole; may function as an RSP5 adapter protein for MVB cargos; integral membrane protein localized to vacuolar intralumenal vesicles cellular protein catabolic process|endosome transport via multivesicular body sorting pathway ubiquitin protein ligase binding fungal-type vacuole lumen|integral to membrane
YBR301W YBR301W PAU24 hom Verified 0.973697878992955 0.165103285370939 no 830 0.152532213617001 539 NA FT CELL WALL ORG/BIOGENESIS Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth biological_process molecular_function fungal-type cell wall
YLR031W_p YLR031W YLR031W hom Uncharacterized 0.972983526139809 0.165280744874936 no 831 0.179016994404492 616 NA Putative protein of unknown function biological_process molecular_function cellular_component
YJR069C YJR069C HAM1 hom Verified 0.971406247645277 0.16567300930588 no 832 0.146981926133226 518 NA FT NUCLEOTIDE METABOLISM NUCLEUS Nucleoside triphosphate pyrophosphohydrolase; active against a wide range of substrates including ITP, dITP and XTP; mediates exclusion of noncanonical purines and pyrimadines from deoxyribonucleoside triphosphate pools; mutant is sensitive to the base analog 6-N-hydroxylaminopurine; protein abundance increases in response to DNA replication stress purine deoxyribonucleoside triphosphate catabolic process|pyrimidine deoxyribonucleoside triphosphate catabolic process dITP diphosphatase activity|ITP diphosphatase activity|XTP diphosphatase activity|dCTP diphosphatase activity|UTP diphosphatase activity|dTTP diphosphatase activity|dATP pyrophosphohydrolase activity|dGTP diphosphatase activity|dUTP diphosphatase activity|GTP diphosphatase activity nucleus|cytoplasm
YCR014C YCR014C POL4 hom Verified 0.969549316425526 0.166135593424275 no 833 0.161972670633075 574 NA FT RESPONSE TO DNA DAMAGE NUCLEUS DNA polymerase IV, undergoes pair-wise interactions with Dnl4p-Lif1p and Rad27p to mediate repair of DNA double-strand breaks by non-homologous end joining (NHEJ); homologous to mammalian DNA polymerase beta double-strand break repair|base-excision repair, gap-filling|double-strand break repair via nonhomologous end joining DNA-directed DNA polymerase activity nucleus
YOR165W YOR165W SEY1 hom Verified 0.967968533693497 0.166530042456603 no 834 0.171596066608891 610 NA FT MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Dynamin-like GTPase that mediates homotypic ER fusion; has a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; functional ortholog of the human atlastin ATL1, defects in which cause a form of the human disease hereditary spastic paraplegia; homolog of Arabidopsis RHD3 cellular membrane organization|endoplasmic reticulum organization|endoplasmic reticulum membrane fusion|endoplasmic reticulum inheritance GTPase activity integral to membrane|endoplasmic reticulum|cortical endoplasmic reticulum|cytoplasm
YDR300C YDR300C PRO1 hom Verified 0.967244790421166 0.166710838013405 no 835 0.171120214163171 576 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Gamma-glutamyl kinase; catalyzes the first step in proline biosynthesis; PRO1 has a paralog, YHR033W, that arose from the whole genome duplication proline biosynthetic process glutamate 5-kinase activity cytoplasm
YDR504C YDR504C SPG3 hom Verified 0.967220977914938 0.166716788676484 no 836 0.141429662435259 481 NA Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources biological_process molecular_function cellular_component
YER027C YER027C GAL83 hom Verified 0.964451689762533 0.16740975895832 no 837 0.166990940415226 521 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|SIGNALING|PROTEIN PHOSPHORYLATION ENDOMEMBRANE SYSTEM|NUCLEUS One of three possible beta-subunits of the Snf1 kinase complex, allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source; contains glycogen-binding domain signal transduction|cell adhesion|protein phosphorylation|invasive growth in response to glucose limitation|regulation of protein complex assembly AMP-activated protein kinase activity AMP-activated protein kinase complex|nucleus|nuclear envelope lumen|cytoplasm
YDR143C YDR143C SAN1 hom Verified 0.963294735321584 0.16769981728448 no 838 0.166139693270887 519 NA FT PROTEOLYSIS NUCLEUS Ubiquitin-protein ligase; involved in the proteasome-dependent degradation of aberrant nuclear proteins; targets substrates with regions of exposed hydrophobicity containing 5 or more contiguous hydrophobic residues; contains intrinsically disordered regions that contribute to substrate recognition nucleus-associated proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to misfolded protein|response to stress ubiquitin-protein ligase activity nucleus|cytoplasm
YEL037C YEL037C RAD23 hom Verified 0.96247082089104 0.167906576833808 no 839 0.161712109661835 539 NA FT RESPONSE TO DNA DAMAGE|PROTEOLYSIS NUCLEUS|MITOCHONDRION Protein with ubiquitin-like N terminus, subunit of Nuclear Excision Repair Factor 2 (NEF2) with Rad4p that binds damaged DNA; enhances protein deglycosylation activity of Png1p; also involved, with Rad4p, in ubiquitylated protein turnover proteasomal ubiquitin-dependent protein catabolic process|nucleotide-excision repair, DNA damage recognition|ER-associated protein catabolic process|protein deglycosylation damaged DNA binding|ubiquitin binding|peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity|protein binding, bridging proteasome complex|mitochondrion|nucleotide-excision repair factor 2 complex
YMR282C YMR282C AEP2 hom Verified 0.961493085375096 0.168152150268285 no 840 0.205461256659077 689 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial protein, likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader mitochondrial translational initiation molecular_function mitochondrion
YHR026W YHR026W VMA16 hom Verified 0.959661699205356 0.168612752771294 no 841 0.272947336643874 915 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS Subunit c'' of the vacuolar ATPase, which functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domain vacuolar acidification proton-transporting ATPase activity, rotational mechanism vacuolar proton-transporting V-type ATPase, V0 domain|integral to membrane
YEL043W YEL043W YEL043W hom Verified 0.958232032575029 0.168972883998331 no 842 0.167030877235175 602 NA FT ENDOPLASMIC RETICULUM Predicted cytoskeleton protein involved in intracellular signalling based on quantitative analysis of protein-protein interaction maps; may interact with ribosomes, based on co-purification studies; contains fibronectin type III domain fold biological_process molecular_function ribosome|endoplasmic reticulum
YLR413W_p YLR413W YLR413W hom Uncharacterized 0.955539104957828 0.169652569816821 no 843 0.159460611481409 573 NA FT PLASMA MEMBRANE Putative protein of unknown function; YLR413W is not an essential gene biological_process molecular_function integral to membrane
YOL132W YOL132W GAS4 hom Verified 0.953175569894993 0.17025056109421 no 844 0.157252968277176 545 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM PLASMA MEMBRANE 1,3-beta-glucanosyltransferase, involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall ascospore wall assembly 1,3-beta-glucanosyltransferase activity fungal-type cell wall|integral to membrane
YDR329C YDR329C PEX3 hom Verified 0.952659546467536 0.170381298097388 no 845 0.176429847792455 601 NA FT PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION ENDOPLASMIC RETICULUM Peroxisomal membrane protein (PMP) required for proper localization and stability of PMPs; anchors peroxisome retention factor Inp1p at the peroxisomal membrane; interacts with Pex19p protein import into peroxisome membrane|peroxisome inheritance|ER-dependent peroxisome organization protein binding peroxisomal membrane|endoplasmic reticulum
YGR072W YGR072W UPF3 hom Verified 0.950701518440391 0.170877958585904 no 846 0.158087618033965 512 NA FT NUCLEUS Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|translational frameshifting|protein ubiquitination molecular_function nucleolus|nucleus|polysome|cytoplasm
YER132C YER132C PMD1 hom Verified 0.950479563804483 0.170934316534965 no 847 0.177023262324815 603 NA FT CELL CYCLE Protein with an N-terminal kelch-like domain, putative negative regulator of early meiotic gene expression; required, with Mds3p, for growth under alkaline conditions sporulation resulting in formation of a cellular spore molecular_function cytoplasm
YDR420W YDR420W HKR1 hom Verified 0.948567707987485 0.171420260619796 no 848 0.145510246065712 486 NA FT CELL CYCLE|SIGNALING|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Mucin family member that functions as an osmosensor in the Sho1p-mediated HOG pathway with Msb2p; proposed to be a negative regulator of filamentous growth; mutant displays defects in beta-1,3 glucan synthesis and bud site selection (1->3)-beta-D-glucan biosynthetic process|fungal-type cell wall organization|osmosensory signaling pathway via Sho1 osmosensor|hyperosmotic response|cellular bud site selection osmosensor activity site of polarized growth|plasma membrane
YJL042W YJL042W MHP1 hom Verified 0.948562235237963 0.171421652916737 no 849 0.15333368163255 495 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION CYTOSKELETON Microtubule-associated protein involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; similar to Drosophila protein MAP and to mammalian MAP4 proteins fungal-type cell wall organization|negative regulation of microtubule depolymerization structural constituent of cytoskeleton microtubule
YDR458C YDR458C HEH2 hom Verified 0.945405609137137 0.172225919830262 no 850 0.179525206570056 653 NA FT ENDOMEMBRANE SYSTEM|NUCLEUS Inner nuclear membrane (INM) protein; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence; targeting to the INM requires the Srp1p-Kap95p karyopherins and the Ran cycle biological_process molecular_function nuclear envelope
YOL097W-A_p YOL097W-A YOL097W-A hom Uncharacterized 0.944642549703052 0.172420698158247 no 851 0.176447294534141 567 NA Putative protein of unknown function; identified by expression profiling and mass spectrometry biological_process molecular_function cellular_component
YGR276C YGR276C RNH70 hom Verified 0.943686954413921 0.17266482121005 no 852 0.169414183381687 566 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS 3'-5' exoribonuclease; required for maturation of 3' ends of 5S rRNA and tRNA-Arg3 from dicistronic transcripts U5 snRNA 3'-end processing|generation of mature 3'-end of 5S rRNA generated by RNA polymerase III|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|tRNA 3'-trailer cleavage, exonucleolytic 3'-5'-exoribonuclease activity|3'-5' exonuclease activity nucleus
YKR021W YKR021W ALY1 hom Verified 0.943418930768949 0.172733331954952 no 853 0.167806713521111 580 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION Alpha arrestin that controls nutrient-mediated intracellular sorting of permease Gap1p; interacts with AP-1 subunit Apl4p; may regulate endocytosis of plasma membrane proteins by recruiting ubiquitin ligase Rsp5p to plasma membrane targets; ALY1 has a paralog, ALY2, that arose from the whole genome duplication Unknown|regulation of intracellular transport|ubiquitin-dependent endocytosis ubiquitin protein ligase binding late endosome|cytoplasm|early endosome
YDR383C YDR383C NKP1 hom Verified 0.942774040527207 0.172898246281949 no 854 0.183005032474104 639 NA FT CELL CYCLE|CELL DIVISION NUCLEUS|CHROMOSOME KINETOCHORE Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein fta4 biological_process molecular_function kinetochore
YIL133C YIL133C RPL16A hom Verified 0.942361800704404 0.173003718712576 no 855 0.175926663184622 632 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L16A; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16A has a paralog, RPL16B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress cytoplasmic translation structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YJL150W_d YJL150W YJL150W hom Dubious 0.94187113768248 0.173129309302138 no 856 0.14972455986304 533 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YML026C YML026C RPS18B hom Verified 0.941789194053661 0.173150289331312 no 857 0.187340682442125 659 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION MITOCHONDRION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18B has a paralog, RPS18A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress cytoplasmic translation|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA export from nucleus structural constituent of ribosome cytosolic small ribosomal subunit|mitochondrion
YNL277W-A_p YNL277W-A YNL277W-A hom Uncharacterized 0.939365772825303 0.173771489888918 no 858 0.139768772669162 446 NA Putative protein of unknown function biological_process molecular_function cellular_component
YCL056C YCL056C PEX34 hom Verified 0.938477966782979 0.173999417394959 no 859 0.172033021664145 599 NA FT PEROXISOME ORGANIZATION Peroxisomal integral membrane protein that regulates peroxisome populations; interacts with Pex11p, Pex25p, and Pex27p to control both constitutive peroxisome division and peroxisome morphology and abundance during peroxisome proliferation peroxisome organization molecular_function integral to peroxisomal membrane|cytoplasm
YJL129C YJL129C TRK1 hom Verified 0.935299028405828 0.174817107944091 no 860 0.222022424736213 754 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication cellular potassium ion homeostasis potassium ion transmembrane transporter activity membrane raft|integral to membrane|plasma membrane
YHR113W YHR113W APE4 hom Verified 0.935288626629745 0.174819787499166 no 861 0.162738809138213 597 NA FT PROTEOLYSIS Cytoplasmic aspartyl aminopeptidase that may also function in the vacuole; CVT pathway cargo protein; cleaves unblocked N-terminal acidic amino acids from peptide substrates; forms a 12-subunit homo-oligomer; M18 metalloprotease family proteolysis aminopeptidase activity fungal-type vacuole lumen|ribosome|cytoplasm
YHL026C_p YHL026C YHL026C hom Uncharacterized 0.934353601777673 0.17506076156405 no 862 0.184307796814482 625 NA Putative protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History) biological_process molecular_function cellular_component
YER120W YER120W SCS2 hom Verified 0.933490726712366 0.175283328094709 no 863 0.170696084771532 625 NA FT PROTEIN LOCALIZATION|LIPID METABOLISM|GENE SILENCING ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH Integral ER membrane protein, regulates phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PI4P levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; interacts with FFAT motif of Opi1p; involved in telomeric silencing; null shows inositol auxotrophy above 34 deg C; VAP homolog; SCS2 has a paralog, SCS22, that arose from the whole genome duplication endoplasmic reticulum inheritance|regulation of intracellular lipid transport|negative regulation of transcription factor import into nucleus|phospholipid biosynthetic process|chromatin silencing at telomere phosphatidylinositol binding|FFAT motif binding nuclear membrane|integral to endoplasmic reticulum membrane|nuclear envelope|endoplasmic reticulum|cellular bud tip
YHR123W YHR123W EPT1 hom Verified 0.932602642820245 0.175512584171076 no 864 0.138728610290552 492 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability; EPT1 has a paralog, CPT1, that arose from the whole genome duplication phosphatidylethanolamine biosynthetic process|phosphatidylcholine biosynthetic process ethanolaminephosphotransferase activity|diacylglycerol cholinephosphotransferase activity integral to membrane|Golgi apparatus
YOR296W_p YOR296W YOR296W hom Uncharacterized 0.932357502804663 0.175575899753257 no 865 0.133533091347725 462 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; expressed during copper starvation; YOR296W is not an essential gene biological_process molecular_function cytoplasm
YGR057C YGR057C LST7 hom Verified 0.932347371302506 0.175578516862924 no 866 0.235588219758903 800 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface intracellular protein transport|vesicle-mediated transport|protein transport|Golgi to plasma membrane transport protein transporter activity vesicle coat
YGL253W YGL253W HXK2 hom Verified 0.930258007824269 0.176118757052174 no 867 0.179034411926794 615 NA FT CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS|MITOCHONDRION Hexokinase isoenzyme 2; catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene; phosphorylation/dephosphorylation at serine-14 by protein kinase Snf1p and protein phosphatase Glc7p-Reg1p regulates nucleocytoplasmic shuttling of Hxk2p; HXK2 has a paralog, HXK1, that arose from the whole genome duplication replicative cell aging|fructose import|regulation of transcription by glucose|glucose import|mannose metabolic process|glycolysis|glucose metabolic process|regulation of cell size|fructose metabolic process hexokinase activity cytosol|mitochondrion|nucleus
YGL210W YGL210W YPT32 hom Verified 0.930012428091198 0.176182324872807 no 868 0.141762064563333 489 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING ENDOMEMBRANE SYSTEM|MITOCHONDRION|GOLGI APPARATUS Rab family GTPase involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; protein abundance increases in response to DNA replication stress; YPT32 has a paralog, YPT31, that arose from the whole genome duplication early endosome to Golgi transport|vesicle-mediated transport|exocytosis GTPase activity endosome|mitochondrial outer membrane|Golgi apparatus
YBR183W YBR183W YPC1 hom Verified 0.928069617267172 0.176685729319594 no 869 0.186664437260738 644 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Alkaline ceramidase; also has reverse (CoA-independent) ceramide synthase activity; catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistance; YPC1 has a paralog, YDC1, that arose from the whole genome duplication ceramide catabolic process|ceramide biosynthetic process phytoceramidase activity|sphingosine N-acyltransferase activity integral to membrane|endoplasmic reticulum
YHR001W-A YHR001W-A QCR10 hom Verified 0.927881652988764 0.176734481211899 no 870 0.156388463733671 554 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Subunit of the ubiqunol-cytochrome c oxidoreductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration ubiquinol-cytochrome-c reductase activity mitochondrion|mitochondrial respiratory chain complex III
YOR188W YOR188W MSB1 hom Verified 0.927084159872073 0.176941419866703 no 871 0.217139554136824 801 NA FT MITOCHONDRION|SITE OF POLARIZED GROWTH Protein of unknown function; may be involved in positive regulation of 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4; potential Cdc28p substrate; relocalizes from bud neck to cytoplasm upon DNA replication stress establishment of cell polarity molecular_function mitochondrion|cellular bud neck|cellular bud tip
YDR368W YDR368W YPR1 hom Verified 0.927073524188457 0.176944180716704 no 872 0.173013476807577 595 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS NUCLEUS NADPH-dependent aldo-keto reductase; reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases; protein abundance increases in response to DNA replication stress; YPR1 has a paralog, GCY1, that arose from the whole genome duplication cellular response to oxidative stress|D-xylose catabolic process|arabinose catabolic process glucose 1-dehydrogenase (NADP+) activity|alditol:NADP+ 1-oxidoreductase activity|carbonyl reductase (NADPH) activity nucleus|cytoplasm
YMR089C YMR089C YTA12 hom Verified 0.926286990742211 0.177148427413323 no 873 0.139061573510401 527 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Component, with Afg3p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes proteolysis|signal peptide processing|protein complex assembly|protein import into mitochondrial intermembrane space metallopeptidase activity|protein binding|ATPase activity|ATP binding mitochondrion|mitochondrial inner boundary membrane|mitochondrial inner membrane|m-AAA complex|cytoplasm
YLL024C YLL024C SSA2 hom Verified 0.926036890048566 0.177213404656775 no 874 0.160167038639447 567 NA FT PROTEIN LOCALIZATION MITOCHONDRION ATP binding protein involved in protein folding and vacuolar import of proteins; member of heat shock protein 70 (HSP70) family; associated with the chaperonin-containing T-complex; present in the cytoplasm, vacuolar membrane and cell wall; 98% identical with paralog Ssa1p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes protein folding|SRP-dependent cotranslational protein targeting to membrane, translocation|response to stress unfolded protein binding|ATPase activity|ATP binding cytosol|fungal-type vacuole membrane|mitochondrion|fungal-type cell wall|plasma membrane|polysome|chaperonin-containing T-complex|cytoplasm
YPL096W YPL096W PNG1 hom Verified 0.923055318027091 0.17798918904252 no 875 0.18782880674104 638 NA FT RESPONSE TO DNA DAMAGE|PROTEOLYSIS NUCLEUS|MITOCHONDRION Conserved peptide N-glycanase required for deglycosylation of misfolded glycoproteins during proteasome-dependent degradation; localizes to the cytoplasm and nucleus; activity is enhanced by interaction with Rad23p misfolded or incompletely synthesized protein catabolic process|protein deglycosylation peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity cytosol|mitochondrion|nucleus
YNR006W YNR006W VPS27 hom Verified 0.922533400678502 0.178125208233998 no 876 0.222356830352753 775 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p) protein retention in Golgi apparatus|late endosome to vacuole transport|protein targeting to vacuole ubiquitin binding|phosphatidylinositol-3-phosphate binding endosome|ESCRT-0 complex
YDR417C_d YDR417C YDR417C hom Dubious 0.922251170618283 0.178198788749578 no 877 0.186195032147647 620 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RPL12B/YDR418W Unknown Unknown Unknown
YNL070W YNL070W TOM7 hom Verified 0.921657729727397 0.17835356787068 no 878 0.198816620158382 705 NA FF|FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex protein import into mitochondrial matrix|protein import into mitochondrial outer membrane protein channel activity mitochondrial outer membrane|mitochondrion|integral to membrane|mitochondrial outer membrane translocase complex
YPR145W YPR145W ASN1 hom Verified 0.921505586838071 0.178393262870508 no 879 0.19178311464856 666 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN1 has a paralog, ASN2, that arose from the whole genome duplication asparagine biosynthetic process asparagine synthase (glutamine-hydrolyzing) activity cytoplasm
YBR047W_p YBR047W FMP23 hom Uncharacterized 0.920986882009811 0.178528637929701 no 880 0.172549963349022 596 NA FT MITOCHONDRION Putative protein of unknown function; proposed to be involved in iron or copper homeostasis; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YOR014W YOR014W RTS1 hom Verified 0.920309764819658 0.178705453843488 no 881 0.209928077093942 762 NA FT PROTEIN LOCALIZATION|CELL CYCLE|SIGNALING|CHROMOSOME SEGREGATION NUCLEUS|SITE OF POLARIZED GROWTH|CHROMOSOME|CYTOSKELETON B-type regulatory subunit of protein phosphatase 2A (PP2A); Rts1p and Cdc55p are alternative regulatory subunits for PP2A catalytic subunits, Pph21p and Pph22p; PP2A-Rts1p protects cohesin when recruited by Sgo1p to the pericentromere; highly enriched at centromeres in the absence of Cdc55p; required for maintenance of septin ring organization during cytokinesis, for ring disassembly in G1 and for dephosphorylation of septin, Shs1p; homolog of the mammalian B' subunit of PP2A mitotic cell cycle spindle orientation checkpoint|cellular protein localization|meiotic sister chromatid cohesion, centromeric|protein dephosphorylation protein serine/threonine phosphatase activity nucleus|spindle pole body|condensed nuclear chromosome, centromeric region|cellular bud neck|cytoplasm
YJL036W YJL036W SNX4 hom Verified 0.920265332399654 0.178717060354839 no 882 0.218305242128107 758 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT Sorting nexin, involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX phosphoinositide-binding domain; forms complexes with Snx41p and with Atg20p piecemeal microautophagy of nucleus|mitochondrion degradation|early endosome to Golgi transport|CVT pathway|protein targeting to vacuole phosphatidylinositol-3-phosphate binding cytosol|pre-autophagosomal structure|extrinsic to membrane|early endosome
YOR202W YOR202W HIS3 hom Verified 0.920092708216991 0.178762157260289 no 883 0.149534748487446 518 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p histidine biosynthetic process imidazoleglycerol-phosphate dehydratase activity cellular_component
YJR080C YJR080C AIM24 hom Verified 0.918936793287482 0.179064316821402 no 884 0.146507501226513 532 NA FT MITOCHONDRION Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss biological_process molecular_function mitochondrion
YGL063W YGL063W PUS2 hom Verified 0.915524216132953 0.179958247774958 no 885 0.175994758450585 610 NA FT RNA PROCESSING MITOCHONDRION Mitochondrial tRNA:pseudouridine synthase; acts at positions 27 and 28, but not at position 72; efficiently and rapidly targeted to mitochondria, specifically dedicated to mitochondrial tRNA modification tRNA pseudouridine synthesis pseudouridine synthase activity mitochondrion
YJR054W YJR054W KCH1 hom Verified 0.915521637634563 0.179958924275224 no 886 0.161804686119528 537 NA Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate biological_process molecular_function integral to membrane|fungal-type vacuole
YJR073C YJR073C OPI3 hom Verified 0.915025534533049 0.180089112640778 no 887 0.225857239400048 802 NA FF|FT LIPID METABOLISM MITOCHONDRION Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis phosphatidylcholine biosynthetic process phosphatidyl-N-dimethylethanolamine N-methyltransferase activity|phosphatidyl-N-methylethanolamine N-methyltransferase activity mitochondrion|integral to membrane
YEL027W YEL027W VMA3 hom Verified 0.913820506578498 0.1804055846411 no 888 0.199045737307831 666 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis cellular copper ion homeostasis|cellular iron ion homeostasis|endocytosis|vacuole organization|proton transport|vacuolar acidification|protein targeting to vacuole hydrogen ion transmembrane transporter activity vacuolar proton-transporting V-type ATPase, V0 domain|integral to membrane
YMR063W YMR063W RIM9 hom Verified 0.91277763552571 0.180679751440737 no 889 0.233950474588429 835 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Plasma membrane protein of unknown function; involved in the proteolytic activation of Rim101p in response to alkaline pH; interacts with Rim21p and Dfg16p to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; has similarity to A. nidulans PalI; ascospore formation molecular_function integral to membrane
YKL136W_d YKL136W YKL136W hom Dubious 0.912491617058076 0.180754990226533 no 890 0.207603978457231 690 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF APL2/YKL135C Unknown Unknown Unknown
YBR210W YBR210W ERV15 hom Verified 0.9115848522829 0.180993649681917 no 891 0.160434901383824 515 NA FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|SIGNALING|CELL DIVISION Protein involved in export of proteins from the endoplasmic reticulum; ERV15 has a paralog, ERV14, that arose from the whole genome duplication ER to Golgi vesicle-mediated transport|axial cellular bud site selection molecular_function integral to membrane|ER to Golgi transport vesicle
YOR069W YOR069W VPS5 hom Verified 0.906281436036363 0.182393454372997 no 892 0.199711615285296 671 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Nexin-1 homolog required for localizing membrane proteins from a prevacuolar/late endosomal compartment back to the late Golgi apparatus; structural component of the retromer membrane coat complex; forms a retromer subcomplex with Vps17p; required for recruiting the retromer complex to the endosome membranes protein retention in Golgi apparatus|retrograde transport, endosome to Golgi protein transporter activity|phosphatidylinositol-3-phosphate binding cytosol|endosome|retromer complex, outer shell|retromer complex
YDR284C YDR284C DPP1 hom Verified 0.905046638235433 0.18272033998294 no 893 0.178092036970521 619 NA FT LIPID METABOLISM|SIGNALING Diacylglycerol pyrophosphate (DGPP) phosphatase, zinc-regulated vacuolar membrane-associated lipid phosphatase, dephosphorylates DGPP to phosphatidate (PA) and Pi, then PA to diacylglycerol; involved in lipid signaling and cell metabolism phospholipid metabolic process|signal transduction diacylglycerol diphosphate phosphatase activity|phosphatidate phosphatase activity fungal-type vacuole membrane|integral to membrane
YIR029W YIR029W DAL2 hom Verified 0.904393567826378 0.182893373822297 no 894 0.171276080479309 595 NA Allantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation allantoin catabolic process allantoicase activity cellular_component
YMR251W-A YMR251W-A HOR7 hom Verified 0.90398984267879 0.183000393686535 no 895 0.166711790419677 596 NA FT ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Protein of unknown function; overexpression suppresses Ca2+ sensitivity of mutants lacking inositol phosphorylceramide mannosyltransferases Csg1p and Csh1p; transcription is induced under hyperosmotic stress and repressed by alpha factor; HOR7 has a paralog, DDR2, that arose from the whole genome duplication plasma membrane organization molecular_function endoplasmic reticulum|plasma membrane
YDR347W YDR347W MRP1 hom Verified 0.903509076495699 0.183127886623697 no 896 0.195056378081072 672 NA FT TRANSLATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit mitochondrial ribosomal protein mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YBR212W YBR212W NGR1 hom Verified 0.903324574459079 0.183176828871576 no 897 0.198739323535573 661 NA FT MITOCHONDRION ORGANIZATION RNA binding protein that negatively regulates growth rate; interacts with the 3' UTR of the mitochondrial porin (POR1) mRNA and enhances its degradation; overexpression impairs mitochondrial function; interacts with Dhh1p to mediate POR1 mRNA decay; expressed in stationary phase 3'-UTR-mediated mRNA destabilization|mitochondrion organization mRNA binding cytoplasmic mRNA processing body|cytoplasmic stress granule|perinuclear region of cytoplasm|cytoplasm
YCR085W_d YCR085W YCR085W hom Dubious 0.902425554944263 0.183415425531476 no 898 0.177001188113857 647 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGR169C YGR169C PUS6 hom Verified 0.902034717963232 0.183519212705708 no 899 0.135891678852442 484 NA FT RNA PROCESSING MITOCHONDRION tRNA:pseudouridine synthase, catalyzes the conversion of uridine to pseudouridine at position 31 in cytoplasmic and mitochondrial tRNAs; mutation of Asp168 to Ala abolishes enzyme activity; not essential for viability tRNA pseudouridine synthesis pseudouridine synthase activity mitochondrion|cytoplasm
YLR191W YLR191W PEX13 hom Verified 0.900191476091697 0.184009180773089 no 900 0.195412439650296 704 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PEROXISOME ORGANIZATION Integral peroxisomal membrane protein required for translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p protein import into peroxisome matrix, docking protein binding, bridging peroxisomal membrane
YPR109W_p YPR109W YPR109W hom Uncharacterized 0.899991318926313 0.184062435261444 no 901 0.204148260174171 660 NA FT CELL CYCLE Predicted membrane protein; dipoid deletion strain has high budding index biological_process molecular_function cellular_component
YKL091C YKL091C YKL091C hom Verified 0.89933066949761 0.184238277961406 no 902 0.188946833011501 662 NA FT NUCLEUS Putative homolog of Sec14p, which is a phosphatidylinositol/phosphatidylcholine transfer protein involved in lipid metabolism; localizes to the nucleus; contains a CRAL/TRIO domain and binds several lipids in a large-scale study biological_process phosphatidylcholine binding|phosphatidylinositol transporter activity|phosphatidylinositol binding|phosphatidylcholine transporter activity nucleus
YKL070W_p YKL070W YKL070W hom Uncharacterized 0.897603450226224 0.184698499486904 no 903 0.157319819455479 534 NA FT OXIDATION-REDUCTION PROCESS MITOCHONDRION Putative protein of unknown function; expression induced in cells treated with mycotoxins patulin or citrinin; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YIL113W YIL113W SDP1 hom Verified 0.897399700690829 0.184752836106808 no 904 0.201706504343838 680 NA FT SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION NUCLEUS Stress-inducible dual-specificity MAP kinase phosphatase, negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock inactivation of MAPK activity involved in cell wall biogenesis|MAPK cascade involved in cell wall biogenesis MAP kinase tyrosine phosphatase activity nucleus|cytoplasm
YFL040W_p YFL040W YFL040W hom Uncharacterized 0.897361659625283 0.184762982128455 no 905 0.173100664296128 536 NA Putative transporter, member of the sugar porter family; YFL040W is not an essential gene transmembrane transport substrate-specific transmembrane transporter activity integral to membrane|membrane
YOR131C YOR131C YOR131C hom Verified 0.897011075982883 0.184856503416676 no 906 0.200009729057359 676 NA FT NUCLEUS Putative haloacid dehalogenase-like hydrolase; non-essential gene; overexpression causes a cell cycle delay or arrest; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus|cytoplasm
YLR373C YLR373C VID22 hom Verified 0.89578458416768 0.185183912402307 no 907 0.202817883116669 714 NA FT PROTEIN LOCALIZATION NUCLEUS|PLASMA MEMBRANE Glycosylated integral membrane protein localized to the plasma membrane; plays a role in fructose-1,6-bisphosphatase (FBPase) degradation; involved in FBPase transport from the cytosol to Vid (vacuole import and degradation) vesicles vacuolar protein catabolic process molecular_function integral to plasma membrane
YDR025W YDR025W RPS11A hom Verified 0.895273303981264 0.185320503690593 no 908 0.193237249479847 650 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11A has a paralog, RPS11B, that arose from the whole genome duplication cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal small subunit assembly structural constituent of ribosome cytosolic small ribosomal subunit|90S preribosome
YPL081W YPL081W RPS9A hom Verified 0.894290336828321 0.185583284407975 no 909 0.187758138510219 671 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION NUCLEUS RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9A has a paralog, RPS9B, that arose from the whole genome duplication cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome|rRNA binding small-subunit processome|cytosolic small ribosomal subunit|90S preribosome|cytoplasm
YBR149W YBR149W ARA1 hom Verified 0.893230092326503 0.185866983068227 no 910 0.173450191114612 592 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM NADP+ dependent arabinose dehydrogenase, involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product cellular carbohydrate metabolic process alditol:NADP+ 1-oxidoreductase activity|D-arabinose 1-dehydrogenase [NAD(P)+] activity cytosol
YBR085C-A YBR085C-A YBR085C-A hom Verified 0.891945200074365 0.186211152903618 no 911 0.160860817645828 576 NA FT NUCLEUS Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus|cytoplasm
YMR178W YMR178W YMR178W hom Verified 0.890686427717423 0.186548709003467 no 912 0.164785533990172 586 NA FT COFACTOR METABOLISM NUCLEUS Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; YMR178W is not an essential gene; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus|cytoplasm
YBR116C_d YBR116C YBR116C hom Dubious 0.889553514023259 0.186852838248117 no 913 0.164398829870594 539 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TKL2 Unknown Unknown Unknown
YDR221W YDR221W GTB1 hom Verified 0.888881504760406 0.187033383183772 no 914 0.176216271226586 608 NA FT CARBOHYDRATE METABOLISM ENDOPLASMIC RETICULUM Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p; involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER; relocalizes from ER to cytoplasm upon DNA replication stress polysaccharide biosynthetic process|protein N-linked glycosylation alpha-glucosidase activity glucosidase II complex|endoplasmic reticulum|endoplasmic reticulum lumen
YNL068C YNL068C FKH2 hom Verified 0.887893849037898 0.187298926852379 no 915 0.17156922553904 639 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|MITOCHONDRION ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Forkhead family transcription factor; plays a major role in the expression of G2/M phase genes; positively regulates transcriptional elongation; negative role in chromatin silencing at HML and HMR; substrate of the Cdc28p/Clb5p kinase; FKH2 has a paralog, FKH1, that arose from the whole genome duplication negative regulation of chromatin silencing at silent mating-type cassette|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription involved in G2/M-phase of mitotic cell cycle|negative regulation of transcription involved in G1 phase of mitotic cell cycle|Unknown|chromatin remodeling|negative regulation of transcription involved in G2/M-phase of mitotic cell cycle RNA polymerase II transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II transcription factor binding transcription factor activity nucleus
YFL034C-A YFL034C-A RPL22B hom Verified 0.88774172859893 0.187339847052116 no 916 0.197208905961705 699 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L22B; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22B has a paralog, RPL22A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YMR159C YMR159C ATG16 hom Verified 0.884012844034332 0.188344639703797 no 917 0.187012117332017 667 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Conserved protein involved in autophagy; interacts with Atg12p-Atg5p conjugates to form Atg12p-Atg5p-Atg16p multimers, which localize to the pre-autophagosomal structure and are required for autophagy; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress C-terminal protein lipidation|piecemeal microautophagy of nucleus|mitochondrion degradation|macroautophagy|CVT pathway protein binding, bridging|Atg8 ligase activity Atg12-Atg5-Atg16 complex|pre-autophagosomal structure
YJR124C_p YJR124C YJR124C hom Uncharacterized 0.88374796309661 0.18841614128868 no 918 0.159119349049734 573 NA Putative protein of unknown function; expression induced under calcium shortage biological_process molecular_function integral to membrane
YER060W YER060W FCY21 hom Verified 0.883530057453821 0.188474974978913 no 919 0.178107432933755 616 NA Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function transmembrane transport nucleobase transmembrane transporter activity integral to membrane
YDR535C_d YDR535C YDR535C hom Dubious 0.88201975466621 0.188883062273867 no 920 0.219234939137548 747 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YDR535C is not an essential gene. Unknown Unknown Unknown
YKL034W YKL034W TUL1 hom Verified 0.880180060810432 0.189380886654539 no 921 0.186936763242106 674 NA FT PROTEOLYSIS ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Subunit of the DSC ubiquitin ligase complex; golgi-localized RING-finger ubiquitin ligase (E3) involved in sorting polar transmembrane domain containing membrane proteins to multivesicular bodies for delivery to the vacuole; proposed involvement in the quality control of misfolded TMD containing proteins; ortholog of fission yeast dsc1 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein ubiquitination ubiquitin-protein ligase activity integral to membrane|Golgi apparatus
YOR337W YOR337W TEA1 hom Verified 0.880132621207226 0.189393734565988 no 922 0.185568893592903 671 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Ty1 enhancer activator required for full levels of Ty enhancer-mediated transcription; C6 zinc cluster DNA-binding protein transcription, DNA-dependent sequence-specific DNA binding|DNA binding nucleus
YJL217W YJL217W REE1 hom Verified 0.879665233094757 0.189520344426296 no 923 0.190789506566968 671 NA Cytoplasmic protein involved in the regulation of enolase (ENO1); mRNA expression is induced by calcium shortage, copper deficiency (via Mac1p) and the presence of galactose (via Gal4p); mRNA expression is also regulated by the cell cycle biological_process molecular_function cytoplasm
YIR002C YIR002C MPH1 hom Verified 0.878811563572941 0.189751727698229 no 924 0.192263241760792 675 NA FT RESPONSE TO DNA DAMAGE NUCLEUS 3'-5' DNA helicase involved in error-free bypass of DNA lesions; binds to flap DNA in an error-free bypass pathway and stimulates the activity of Rad27p and Dna2p; also involved in interstrand cross-link repair mutations confer a mutator phenotype; similarity to FANCM, a human Fanconi anemia complementation group protein that along with the MHF complex is involved in stabilizing and remodeling blocked replication forks; member of the SF2 DExD/H superfamily of helicases negative regulation of strand invasion|recombinational repair|DNA replication, Okazaki fragment processing flap-structured DNA binding|3'-5' DNA helicase activity nucleus
YPR129W YPR129W SCD6 hom Verified 0.875593969120214 0.190625402578306 no 925 0.217156804663319 748 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION Repressor of translation initiation; binds eIF4G through its RGG domain and inhibits recruitment of the preinitiation complex; also contains an Lsm domain; may have a role in RNA processing; overproduction suppresses null mutation in clathrin heavy chain gene CHC1; forms cytoplasmic foci upon DNA replication stress stress granule assembly|negative regulation of translational initiation|cytoplasmic mRNA processing body assembly mRNA binding|RNA binding|eukaryotic initiation factor 4G binding cytoplasmic mRNA processing body|cytoplasmic stress granule|cytoplasm
YMR299C YMR299C DYN3 hom Verified 0.874720340954516 0.190863044802218 no 926 0.188568704077155 679 NA FT CYTOSKELETON Dynein light intermediate chain (LIC); localizes with dynein, null mutant is defective in nuclear migration nuclear migration along microtubule motor activity cytoplasmic dynein complex|cytoplasmic microtubule
YDL202W YDL202W MRPL11 hom Verified 0.874355252018172 0.190962409239107 no 927 0.195998319495502 682 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YJR135C YJR135C MCM22 hom Verified 0.873410710664574 0.191219627553088 no 928 0.173822156343746 592 NA FT CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME KINETOCHORE Outer kinetochore protein and component of the Ctf3 subcomplex; binds to centromeric DNA in a Ctf19p-dependent manner; involved in chromosome segregation and minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-K and fission yeast sim4 chromosome segregation|establishment of mitotic sister chromatid cohesion molecular_function condensed nuclear chromosome kinetochore
YLR266C YLR266C PDR8 hom Verified 0.873307065932322 0.19124786510183 no 929 0.176468820854014 596 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Transcription factor; targets include ATP-binding cassette (ABC) transporters, major facilitator superfamily transporters, and other genes involved in the pleiotropic drug resistance (PDR) phenomenon; PDR8 has a paralog, YRR1, that arose from the whole genome duplication positive regulation of transcription from RNA polymerase II promoter in response to stress RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|sequence-specific DNA binding nucleus
YMR039C YMR039C SUB1 hom Verified 0.869680336562907 0.192237560503084 no 930 0.178433004493431 585 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Transcriptional coactivator; facilitates elongation through factors that modify RNAP II; role in peroxide resistance involving Rad2p; role in the hyperosmotic stress response through polymerase recruitment at RNAP II and RNAP III genes; protein abundance increases in response to DNA replication stress termination of RNA polymerase II transcription|hyperosmotic response|RNA polymerase III transcriptional preinitiation complex assembly|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase III promoter transcription coactivator activity nucleus
YJL122W YJL122W ALB1 hom Verified 0.869435159535048 0.192304579535161 no 931 0.163388402593029 574 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS NUCLEUS Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p ribosomal large subunit biogenesis molecular_function ribosome|nucleus|cytoplasm
YGR110W YGR110W CLD1 hom Verified 0.868871502377538 0.192458709149059 no 932 0.206564336058949 653 NA FT LIPID METABOLISM MITOCHONDRION Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58 cardiolipin acyl-chain remodeling|cardiolipin metabolic process phospholipase A2 activity mitochondrion
YJR062C YJR062C NTA1 hom Verified 0.867149237094112 0.192930122901588 no 933 0.170051923839287 603 NA FT PROTEOLYSIS MITOCHONDRION Amidase, removes the amide group from N-terminal asparagine and glutamine residues to generate proteins with N-terminal aspartate and glutamate residues that are targets of ubiquitin-mediated degradation cellular protein modification process|protein catabolic process protein-N-terminal asparagine amidohydrolase activity mitochondrion
YIL087C YIL087C AIM19 hom Verified 0.864440074532953 0.193673093182613 no 934 0.180476059632459 598 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth biological_process molecular_function mitochondrion
YNL230C YNL230C ELA1 hom Verified 0.864072180973554 0.193774119979135 no 935 0.204334850141192 735 NA FT PROTEOLYSIS NUCLEUS UBIQUITIN LIGASE COMPLEX Elongin A; F-box protein that forms a heterodimer with Elc1p and is required for ubiquitin-dependent degradation of the RNA Polymerase II subunit Rpo21p; subunit of the Elongin-Cullin-Socs (ECS) ligase complex protein ubiquitination involved in ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity elongin complex|Cul3-RING ubiquitin ligase complex
YNL092W_p YNL092W YNL092W hom Uncharacterized 0.86321229497272 0.194010377482148 no 936 0.17417924648768 571 NA Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; YNL092W is not an essential gene biological_process S-adenosylmethionine-dependent methyltransferase activity cellular_component
YHL045W_d YHL045W YHL045W hom Dubious 0.862832107961797 0.194114891486024 no 937 0.186736020190977 621 NA Putative protein of unknown function; not an essential gene Unknown Unknown Unknown
YBR147W YBR147W RTC2 hom Verified 0.862681200521086 0.194156385684337 no 938 0.170079508863032 583 NA FT MITOCHONDRION Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; positive regulation by Lys14p suggests that lysine may be the primary substrate; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter biological_process molecular_function mitochondrion|integral to membrane
YPL239W YPL239W YAR1 hom Verified 0.861745486937617 0.194413794350189 no 939 0.19225965258547 636 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RESPONSE TO OXIDATIVE STRESS Ankyrin-repeat containing, nucleocytoplasmic shuttling chaperone; prevents aggregation of Rps3p in the cytoplasm, associates with free Rps3p in the cytoplasm and delivers it to the 90S in the nucleus; required for 40S ribosomal subunit export, biogenesis and adaptation to osmotic and oxidative stress; expression repressed by heat shock ribosomal small subunit biogenesis|cellular response to oxidative stress|response to osmotic stress molecular_function cytoplasm
YPL227C YPL227C ALG5 hom Verified 0.861573512546441 0.19446112596668 no 940 0.203335666926394 709 NA FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM UDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum protein N-linked glycosylation dolichyl-phosphate beta-glucosyltransferase activity endoplasmic reticulum membrane
YHL034C YHL034C SBP1 hom Verified 0.8608969322623 0.19464740570699 no 941 0.177043580396252 659 NA FT TRANSLATION NUCLEUS Protein that binds eIF4G and has a role in repression of translation; has an RGG motif; found in cytoplasmic P bodies; found associated with small nucleolar RNAs snR10 and snR11 negative regulation of translation|negative regulation of translation in response to stress RNA binding|eukaryotic initiation factor 4G binding nucleolus|cytoplasmic mRNA processing body|cytoplasm
YER087C-A_d YER087C-A YER087C-A hom Dubious 0.860888180232199 0.19464981607432 no 942 0.182444490154298 596 NA Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; overlaps the uncharacterized gene YER087W, a putative tRNA synthetase Unknown Unknown Unknown
YHL024W YHL024W RIM4 hom Verified 0.860595885283443 0.19473032647953 no 943 0.215967111141205 713 NA FT CELL CYCLE Putative RNA-binding protein required for the expression of early and middle sporulation genes meiosis|reciprocal meiotic recombination|sporulation resulting in formation of a cellular spore|premeiotic DNA replication RNA binding cytoplasm
YLR125W_p YLR125W YLR125W hom Uncharacterized 0.859273262989992 0.195094885821802 no 944 0.190762665465072 673 NA Putative protein of unknown function; mutant has decreased Ty3 transposition; YLR125W is not an essential gene biological_process molecular_function cellular_component
YDR105C YDR105C TMS1 hom Verified 0.859122140189807 0.195136566758631 no 945 0.20388772420594 685 NA Vacuolar membrane protein of unknown function that is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p, a protein involved in multidrug resistance biological_process molecular_function fungal-type vacuole membrane|integral to membrane|membrane
YML131W YML131W YML131W hom Verified 0.858144023441725 0.195406470426308 no 946 0.16589546043301 554 NA FT OXIDATION-REDUCTION PROCESS Protein of unknown function; similar to medium chain dehydrogenase/reductases; expression induced by stresses including osmotic shock, DNA damaging agents, and other chemicals; GFP-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress biological_process molecular_function cytoplasm
YFL028C YFL028C CAF16 hom Verified 0.857252579682919 0.195652654769797 no 947 0.183052580641364 618 NA FT TRANSCRIPTION FROM RNA POL II|NUCLEOTIDE METABOLISM NUCLEUS Part of evolutionarily-conserved CCR4-NOT regulatory complex; contains single ABC-type ATPase domain but no transmembrane domain; interacts with several subunits of Mediator regulation of transcription from RNA polymerase II promoter ATPase activity CCR4-NOT complex|cytoplasm
YMR086C-A_d YMR086C-A YMR086C-A hom Dubious 0.856270866323957 0.195923986047618 no 948 0.19202819252156 678 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YNR032W YNR032W PPG1 hom Verified 0.853444405793379 0.196706452539931 no 949 0.193425181749548 625 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Putative serine/threonine protein phosphatase of the type 2A-like phosphatase family, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases glycogen metabolic process|protein dephosphorylation protein serine/threonine phosphatase activity nucleus|cytoplasm
YPR147C_p YPR147C YPR147C hom Uncharacterized 0.853096628392159 0.19680286050286 no 950 0.205599741728227 728 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS biological_process molecular_function cytoplasm
YJR049C YJR049C UTR1 hom Verified 0.850222409226569 0.197600722563386 no 951 0.224573666602936 770 NA FF|FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|COFACTOR METABOLISM NUCLEUS ATP-NADH kinase; phosphorylates both NAD and NADH; active as a hexamer; enhances the activity of ferric reductase (Fre1p); UTR1 has a paralog, YEF1, that arose from the whole genome duplication cellular iron ion homeostasis|NADP biosynthetic process NAD+ kinase activity|NADH kinase activity nucleus|cytoplasm
YBL075C YBL075C SSA3 hom Verified 0.849310395101997 0.197854299041276 no 952 0.208149166668601 741 NA FT PROTEIN LOCALIZATION ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm; SSA3 has a paralog, SSA4, that arose from the whole genome duplication protein folding|SRP-dependent cotranslational protein targeting to membrane, translocation|response to stress unfolded protein binding|ATPase activity cytosol
YPL104W YPL104W MSD1 hom Verified 0.849198416894975 0.197885447015675 no 953 0.226797670218554 793 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial aspartyl-tRNA synthetase, required for acylation of aspartyl-tRNA; yeast and bacterial aspartyl-, asparaginyl-, and lysyl-tRNA synthetases contain regions with high sequence similarity, suggesting a common ancestral gene mitochondrial aspartyl-tRNA aminoacylation aspartate-tRNA ligase activity mitochondrion
YLR080W YLR080W EMP46 hom Verified 0.848394019777146 0.198109286011329 no 954 0.171959694975855 573 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport ER to Golgi vesicle-mediated transport glycoprotein binding ER to Golgi transport vesicle|Golgi membrane
YFR012W YFR012W DCV1 hom Verified 0.84673467518521 0.198571513307049 no 955 0.178919139624224 630 NA Protein of unknown function; deletion mutant shows strong genetic interaction with cdc28-as1 mutant in the presence of 1-NM-PP1; DCV1 has a paralog, YOL019W, that arose from the whole genome duplication biological_process molecular_function integral to membrane
YNL014W YNL014W HEF3 hom Verified 0.844885090497926 0.199087499829975 no 956 0.21145913936822 707 NA FT TRANSLATION|NUCLEOTIDE METABOLISM RIBOSOME Translational elongation factor EF-3; member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells; HEF3 has a paralog, YEF3, that arose from the whole genome duplication translational elongation ATPase activity|translation elongation factor activity cytosolic ribosome
YCL001W-A_p YCL001W-A YCL001W-A hom Uncharacterized 0.842694340364204 0.199699706644858 no 957 0.225073107006168 792 NA Putative protein of unknown function; YCL001W-A gene has similarity to DOM34 and is present in a region duplicated between chromosomes XIV and III biological_process molecular_function cellular_component
YJL077C YJL077C ICS3 hom Verified 0.842637592821338 0.199715579824326 no 958 0.203590158365884 689 NA Protein of unknown function; may play a role in vacuolar sorting, null mutants are hypersensitive to sortin2 biological_process molecular_function cellular_component
YLR194C YLR194C YLR194C hom Verified 0.842577352560343 0.199732430802489 no 959 0.197094384161813 661 NA FT CELL WALL ORG/BIOGENESIS PLASMA MEMBRANE Structural constituent of the cell wall attached to the plasma membrane by a GPI-anchor; expression is upregulated in response to cell wall stress fungal-type cell wall organization structural constituent of cell wall fungal-type cell wall|anchored to plasma membrane
YGR220C YGR220C MRPL9 hom Verified 0.841049056564696 0.2001602263412 no 960 0.179816577067616 579 NA FT TRANSLATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit cytoplasmic translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YLR013W YLR013W GAT3 hom Verified 0.835396887851793 0.201747140753947 no 961 0.195205373363914 648 NA FT NUCLEUS Protein containing GATA family zinc finger motifs transcription, DNA-dependent sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nucleus
YOR374W YOR374W ALD4 hom Verified 0.835057720550118 0.201842605081231 no 962 0.188499128821414 636 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM MITOCHONDRION Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed NADPH regeneration|ethanol metabolic process|pyruvate metabolic process|acetate biosynthetic process aldehyde dehydrogenase [NAD(P)+] activity|aldehyde dehydrogenase (NAD) activity mitochondrial nucleoid|mitochondrion
YJL154C YJL154C VPS35 hom Verified 0.83487886961988 0.201892956565936 no 963 0.242669988643141 853 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p protein retention in Golgi apparatus|retrograde transport, endosome to Golgi protein transporter activity endosome|retromer complex, inner shell|retromer complex
YHL030W YHL030W ECM29 hom Verified 0.833762911690566 0.202207299400845 no 964 0.191436685027856 685 NA FT PROTEIN COMPLEX ORG/BIOGENESIS NUCLEUS Scaffold protein; assists in association of the proteasome core particle with the regulatory particle; degraded by the mature proteasome after assembly; contains HEAT-like repeats; protein increases in abundance and relocalizes from nucleus to cytoplasm upon DNA replication stress proteasome assembly protein complex scaffold proteasome complex|nucleus|cytoplasm
YPL201C YPL201C YIG1 hom Verified 0.833724490975815 0.202218126952316 no 965 0.204654314107377 713 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol glycerol biosynthetic process molecular_function cytosol|nucleus
YDL073W_p YDL073W YDL073W hom Uncharacterized 0.833719202419304 0.202219617376468 no 966 0.234529457061017 853 NA Putative protein of unknown function; YDL073W is not an essential gene biological_process molecular_function cellular_component
YLR354C YLR354C TAL1 hom Verified 0.833399308258736 0.202309782359978 no 967 0.234373201983213 769 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS NUCLEUS Transaldolase, enzyme in the non-oxidative pentose phosphate pathway; converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate pentose-phosphate shunt sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity nucleus|cytoplasm
YDR282C_p YDR282C YDR282C hom Uncharacterized 0.833331629052538 0.20232886142098 no 968 0.173038689762109 605 NA Putative protein of unknown function; localizes to the inner mitochondrial membrane with the C terminus facing the intermembrane space; ortholog of human RMND1, mutation in which is implicated in infantile encephaloneuromyopathy and defective mitochondrial translation biological_process molecular_function cellular_component
YAL030W YAL030W SNC1 hom Verified 0.831647551763141 0.202803956552809 no 969 0.185057992562679 676 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|GOLGI APPARATUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; proposed to be involved in endocytosis; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC1 has a paralog, SNC2, that arose from the whole genome duplication endocytosis|exocytosis|Golgi to plasma membrane transport|vesicle fusion SNAP receptor activity SNARE complex|trans-Golgi network|endosome|transport vesicle membrane|plasma membrane|cellular bud neck
YIR028W YIR028W DAL4 hom Verified 0.831357621750591 0.202885815920572 no 970 0.196344276455158 656 NA Allantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation allantoin catabolic process|allantoin transport allantoin uptake transmembrane transporter activity integral to membrane|membrane
YHR136C YHR136C SPL2 hom Verified 0.829961457582552 0.203280287731083 no 971 0.216512059346216 740 NA Protein with similarity to cyclin-dependent kinase inhibitors; downregulates low-affinity phosphate transport during phosphate limitation; overproduction suppresses a plc1 null mutation; GFP-fusion protein localizes to the cytoplasm response to temperature stimulus enzyme inhibitor activity cytoplasm
YNL173C YNL173C MDG1 hom Verified 0.82926699932245 0.203476670103075 no 972 0.219400131907394 761 NA FT SIGNALING PLASMA MEMBRANE Plasma membrane protein involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations pheromone-dependent signal transduction involved in conjugation with cellular fusion molecular_function membrane raft|plasma membrane
YJR034W YJR034W PET191 hom Verified 0.828631943973534 0.203656353250381 no 973 0.214427373481911 738 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Protein required for assembly of cytochrome c oxidase; exists as an oligomer; described as both an integral mitochondrial inner membrane protein facing the intermembrane space (IMS) and as a soluble IMS protein; contains a twin Cx9C motif; imported into the IMS via the MIA import machinery mitochondrial respiratory chain complex IV assembly molecular_function mitochondrion|integral to mitochondrial inner membrane
YHR171W YHR171W ATG7 hom Verified 0.827647525700708 0.203935072394985 no 974 0.25370587772563 866 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS MITOCHONDRION Autophagy-related protein and dual specificity member of the E1 family of ubiquitin-activating enzymes; mediates the conjugation of Atg12p with Atg5p and Atg8p with phosphatidylethanolamine, required steps in autophagosome formation C-terminal protein lipidation|protein modification by small protein conjugation|piecemeal microautophagy of nucleus|mitochondrion degradation|macroautophagy|CVT pathway APG8 activating enzyme activity|APG12 activating enzyme activity cytosol|mitochondrion|membrane|pre-autophagosomal structure
YDR153C YDR153C ENT5 hom Verified 0.827045070911529 0.204105757972708 no 975 0.185558822852844 615 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin late endosome to vacuole transport via multivesicular body sorting pathway|early endosome to Golgi transport|Golgi to endosome transport clathrin binding|phosphatidylinositol-3,5-bisphosphate binding endosome|clathrin vesicle coat|cytoplasm
YOR246C YOR246C ENV9 hom Verified 0.823643604692351 0.205071046002928 no 976 0.216068838046543 770 NA FF|FT OXIDATION-REDUCTION PROCESS|VACUOLAR PROTEIN PROCESSING Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts vacuole organization|vacuolar protein processing oxidoreductase activity lipid particle
YPR087W_d YPR087W VPS69 hom Dubious 0.8231293445091 0.205217221531553 no 977 0.22820373036525 758 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene SRP54; deletion causes a vacuolar protein sorting defect Unknown Unknown Unknown
YOR307C YOR307C SLY41 hom Verified 0.822218983069302 0.205476138331146 no 978 0.216588691323922 703 NA FT VESICLE-MEDIATED TRANSPORT ENDOPLASMIC RETICULUM Protein involved in ER-to-Golgi transport ER to Golgi vesicle-mediated transport molecular_function integral to membrane|endoplasmic reticulum
YIL088C YIL088C AVT7 hom Verified 0.819856131646912 0.206149063716115 no 979 0.181378649651618 602 NA FT PLASMA MEMBRANE Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters amino acid transport amino acid transmembrane transporter activity integral to membrane|plasma membrane|fungal-type vacuole
YNL069C YNL069C RPL16B hom Verified 0.819326505197887 0.206300077096276 no 980 0.232192571492864 790 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L16B; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16B has a paralog, RPL16A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YGR078C YGR078C PAC10 hom Verified 0.818397788477263 0.206565042061395 no 981 0.243435241033783 827 NA FT PROTEIN COMPLEX ORG/BIOGENESIS Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding tubulin complex assembly tubulin binding prefoldin complex|polysome|cytoplasm
YOL013W-B_d YOL013W-B YOL013W-B hom Dubious 0.817991454822451 0.206681033325294 no 982 0.178826585177043 632 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the long terminal repeat (LTR) of a Ty1 element Unknown Unknown Unknown
YDR216W YDR216W ADR1 hom Verified 0.817817253709941 0.206730772266461 no 983 0.220340467478806 742 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|CHROMATIN ORGANIZATION|OXIDATION-REDUCTION PROCESS|RESPONSE TO NUTRIENT LEVELS|GENE SILENCING|PEROXISOME ORGANIZATION NUCLEUS Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization negative regulation of chromatin silencing|positive regulation of transcription from RNA polymerase II promoter in response to ethanol|chromatin organization|regulation of transcription by chromatin organization|positive regulation of fatty acid beta-oxidation by positive regulation of transcription from RNA polymerase II promoter|positive regulation of peroxisome organization by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter by oleic acid|cellular response to oleic acid|peroxisome organization|positive regulation of ethanol catabolic process by positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|TFIIB-class transcription factor binding|sequence-specific DNA binding|TFIID-class transcription factor binding|RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription nucleus
YIR037W YIR037W HYR1 hom Verified 0.817302956079602 0.206877658937746 no 984 0.214439429342326 752 NA FT OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS Thiol peroxidase that functions as a hydroperoxide receptor to sense intracellular hydroperoxide levels and transduce a redox signal to the Yap1p transcription factor cellular response to oxidative stress phospholipid-hydroperoxide glutathione peroxidase activity|glutathione peroxidase activity intracellular
YOR297C YOR297C TIM18 hom Verified 0.816564182966079 0.207088765298589 no 985 0.173298380778649 578 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS MITOCHONDRION Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex cellular response to oxidative stress|protein import into mitochondrial inner membrane|apoptotic process|response to acid|response to osmotic stress|response to arsenic-containing substance protein channel activity mitochondrion|integral to membrane|mitochondrial inner membrane protein insertion complex
YER068W YER068W MOT2 hom Verified 0.815776770994042 0.207313910586381 no 986 0.223180652389318 760 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications deadenylation-independent decapping of nuclear-transcribed mRNA|positive regulation of transcription elongation from RNA polymerase II promoter|protein polyubiquitination|protein ubiquitination ubiquitin-protein ligase activity|sequence-specific DNA binding CCR4-NOT core complex|cytoplasm
YKR040C_d YKR040C YKR040C hom Dubious 0.815157808602238 0.207490992519695 no 987 0.198783450512602 669 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YKR041W Unknown Unknown Unknown
YDR194C YDR194C MSS116 hom Verified 0.815099109936074 0.207507790543819 no 988 0.222459600804335 765 NA FT RNA PROCESSING|TRANSLATION MITOCHONDRION DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing RNA folding|Group I intron splicing|Group II intron splicing RNA binding|RNA strand annealing activity|ATP-dependent RNA helicase activity mitochondrion|mitochondrial matrix
YKL119C YKL119C VPH2 hom Verified 0.814347097332988 0.207723067996617 no 989 0.215289045042304 714 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Integral membrane protein required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER) vacuolar proton-transporting V-type ATPase complex assembly|vacuolar acidification molecular_function endoplasmic reticulum membrane
YDR182W-A_p YDR182W-A YDR182W-A hom Uncharacterized 0.813724354877344 0.207901439312025 no 990 0.218152841610686 717 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YAL062W YAL062W GDH3 hom Verified 0.812874663579543 0.208144961123953 no 991 0.187305253841405 639 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS NUCLEUS|MITOCHONDRION NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources; GDH3 has a paralog, GDH1, that arose from the whole genome duplication glutamate biosynthetic process|ammonia assimilation cycle glutamate dehydrogenase (NADP+) activity mitochondrion|nucleus
YKL159C YKL159C RCN1 hom Verified 0.811682079187239 0.208487040006029 no 992 0.198960270132171 682 NA FT SIGNALING Protein involved in calcineurin regulation during calcium signaling; has similarity to H. sapiens DSCR1 which is found in the Down Syndrome candidate region calcium-mediated signaling protein phosphatase 2B binding|calcium-dependent protein serine/threonine phosphatase regulator activity cytoplasm
YPL182C_d YPL182C YPL182C hom Dubious 0.810868894468957 0.208720482504862 no 993 0.209006176224117 723 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CTI6/YPL181W Unknown Unknown Unknown
YOL106W_d YOL106W YOL106W hom Dubious 0.810725910852621 0.208761545005224 no 994 0.196787269746017 660 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YBR006W YBR006W UGA2 hom Verified 0.810004183803839 0.208968885578544 no 995 0.258767760014382 913 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm cellular response to oxidative stress|gamma-aminobutyric acid catabolic process|glutamate decarboxylation to succinate succinate-semialdehyde dehydrogenase [NAD(P)+] activity cytoplasm
YNL067W-B_p YNL067W-B YNL067W-B hom Uncharacterized 0.809806148779219 0.209025799056506 no 996 0.225555877386131 777 NA Putative protein of unknown function biological_process molecular_function cellular_component
YGL166W YGL166W CUP2 hom Verified 0.809452343435901 0.209127502238558 no 997 0.21854685164069 724 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations; CUP2 has a paralog, HAA1, that arose from the whole genome duplication regulation of transcription from RNA polymerase II promoter|response to copper ion RNA polymerase II core promoter proximal region sequence-specific DNA binding|copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity|copper ion binding nucleus
YBR220C_p YBR220C YBR220C hom Uncharacterized 0.807876117191824 0.209580950569133 no 998 0.207419665155539 701 NA Putative protein of unknown function; YBR220C is not an essential gene biological_process molecular_function integral to membrane
YGR127W_p YGR127W YGR127W hom Uncharacterized 0.807709904993038 0.209628800131406 no 999 0.188595745893945 638 NA Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response biological_process molecular_function cellular_component
YMR199W YMR199W CLN1 hom Verified 0.806107081524866 0.210090554366948 no 1000 0.188824154488377 665 NA FT CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION NUCLEUS G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p) regulation of cyclin-dependent protein kinase activity cyclin-dependent protein kinase regulator activity nucleus|cytoplasm
YCL034W YCL034W LSB5 hom Verified 0.804820764137435 0.210461558815589 no 1001 0.23198655101173 775 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION CYTOSKELETON Protein of unknown function; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; may mediate disassembly of the Pan1 complex from the endocytic coat endocytosis|actin filament organization|actin cortical patch localization|actin cytoskeleton organization molecular_function cell cortex|cytoplasm|actin cortical patch
YKR017C YKR017C HEL1 hom Verified 0.804652427560477 0.210510139517961 no 1002 0.216376210515882 740 NA RING finger ubiquitin ligase (E3); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU) biological_process molecular_function cellular_component
YOR050C_d YOR050C YOR050C hom Dubious 0.803341065164645 0.210888814371246 no 1003 0.185388664874066 628 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable Unknown Unknown Unknown
YMR175W YMR175W SIP18 hom Verified 0.803163692279865 0.210940064005662 no 1004 0.18718138298381 649 NA Phospholipid-binding hydrophilin; essential to overcome desiccation-rehydration process; expression is induced by osmotic stress cellular response to water deprivation phospholipid binding cytoplasm
YGR102C YGR102C GTF1 hom Verified 0.801412527718703 0.211446432485182 no 1005 0.21227092304445 751 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION MITOCHONDRION Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria glutaminyl-tRNAGln biosynthesis via transamidation glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity mitochondrion|glutamyl-tRNA(Gln) amidotransferase complex
YCL033C YCL033C MXR2 hom Verified 0.801178395271627 0.211514188363853 no 1006 0.20051375755685 688 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS MITOCHONDRION Methionine-R-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR1; involved in the regulation of lifespan cellular response to oxidative stress peptide-methionine (R)-S-oxide reductase activity mitochondrion
YIL098C YIL098C FMC1 hom Verified 0.800813535010398 0.211619801064049 no 1007 0.224837225992729 753 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial matrix protein, required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase; null mutant temperature sensitive growth on glycerol is suppressed by multicopy expression of Odc1p mitochondrial proton-transporting ATP synthase complex assembly molecular_function mitochondrion|mitochondrial matrix
YBR108W YBR108W AIM3 hom Verified 0.800529450019689 0.211702053869885 no 1008 0.205099295662499 695 NA FT CYTOSKELETON ORGANIZATION CYTOSKELETON Protein interacting with Rvs167p; null mutant is viable and displays elevated frequency of mitochondrial genome loss actin cortical patch assembly molecular_function membrane raft|actin cortical patch
YDL130W-A YDL130W-A STF1 hom Verified 0.799865326372004 0.211894414497417 no 1009 0.227924735621151 814 NA FT NUCLEOTIDE METABOLISM MITOCHONDRION Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p act as stabilizing factors that enhance inhibitory action of the Inh1p protein; protein abundance increases in response to DNA replication stress negative regulation of ATPase activity molecular_function mitochondrion|mitochondrial proton-transporting ATP synthase complex
YOR124C YOR124C UBP2 hom Verified 0.798832108249288 0.212193884982754 no 1010 0.202994973156124 707 NA FT PROTEOLYSIS Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; interacts with Rsp5p and is required for MVB sorting of membrane proteins; can cleave polyubiquitin and has isopeptidase activity protein deubiquitination|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ubiquitin-specific protease activity cytoplasm
YER177W YER177W BMH1 hom Verified 0.798058734619778 0.212418203320587 no 1011 0.215090653344641 764 NA FT CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS 14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress glycogen metabolic process|pseudohyphal growth|signal transduction involved in filamentous growth|ascospore formation|fungal-type cell wall chitin biosynthetic process|Ras protein signal transduction|DNA damage checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle DNA replication origin binding|phosphoserine binding plasma membrane|nucleus
YCL044C YCL044C MGR1 hom Verified 0.797027515739315 0.212717525552886 no 1012 0.201491286778314 669 NA FT PROTEOLYSIS MITOCHONDRION Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr3p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA misfolded or incompletely synthesized protein catabolic process misfolded protein binding mitochondrion|i-AAA complex
YOR067C YOR067C ALG8 hom Verified 0.796679452953626 0.21281861003354 no 1013 0.255333535624558 898 NA FF|FT LIPID METABOLISM|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Glucosyl transferase, involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p oligosaccharide-lipid intermediate biosynthetic process|protein N-linked glycosylation dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity integral to membrane|endoplasmic reticulum membrane
YCL055W YCL055W KAR4 hom Verified 0.796210478187651 0.212954854134236 no 1014 0.194126701322943 697 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE NUCLEUS Transcription factor required for gene regulation in response to pheromones; also required during meiosis; exists in two forms, a slower-migrating form more abundant during vegetative growth and a faster-migrating form induced by pheromone karyogamy involved in conjugation with cellular fusion|meiosis|negative regulation of transcription from RNA polymerase II promoter by pheromones|positive regulation of transcription from RNA polymerase II promoter by pheromones|G1 phase of mitotic cell cycle sequence-specific DNA binding transcription factor activity nucleus|cytoplasm
YKL167C YKL167C MRP49 hom Verified 0.795510730480351 0.213158235783679 no 1015 0.218047014286453 741 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YPL095C YPL095C EEB1 hom Verified 0.795102369335849 0.213276978268009 no 1016 0.229901913985244 799 NA FT KETONE METABOLISM|LIPID METABOLISM Acyl-coenzymeA:ethanol O-acyltransferase; responsible for the major part of medium-chain fatty acid ethyl ester biosynthesis during fermentation; possesses short-chain esterase activity; may be involved in lipid metabolism and detoxification; EEB1 has a paralog, EHT1, that arose from the whole genome duplication medium-chain fatty acid catabolic process|medium-chain fatty acid biosynthetic process short-chain carboxylesterase activity|alcohol O-octanoyltransferase activity cellular_component
YMR322C_p YMR322C SNO4 hom Uncharacterized 0.794258529089018 0.213522470705773 no 1017 0.176343094999039 554 NA FT PROTEOLYSIS Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation biological_process cysteine-type peptidase activity cellular_component
YGR130C YGR130C YGR130C hom Verified 0.794239190370693 0.213528098710946 no 1018 0.236642342739727 813 NA Component of the eisosome with unknown function; GFP-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7) biological_process molecular_function eisosome|membrane raft|cytoplasm
YMR184W YMR184W ADD37 hom Verified 0.793657856847685 0.213697320289962 no 1019 0.21220439872756 688 NA FT PROTEOLYSIS Protein of unknown function; involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene; protein abundance increases in response to DNA replication stress ER-associated protein catabolic process molecular_function cytoplasm
YEL022W YEL022W GEA2 hom Verified 0.793561652813285 0.213725332053256 no 1020 0.246990710492942 852 NA FT VESICLE-MEDIATED TRANSPORT|SIGNALING|CYTOSKELETON ORGANIZATION|RESPONSE TO NUTRIENT LEVELS GOLGI APPARATUS Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA2 has a paralog, GEA1, that arose from the whole genome duplication retrograde vesicle-mediated transport, Golgi to ER|secretory granule organization|ER to Golgi vesicle-mediated transport|macroautophagy|intra-Golgi vesicle-mediated transport|actin cytoskeleton organization ARF guanyl-nucleotide exchange factor activity integral to membrane|Golgi cis cisterna|extrinsic to membrane
YNL089C_d YNL089C YNL089C hom Dubious 0.793129588040451 0.213851162877659 no 1021 0.215244368490167 736 NA Dubious open reading frame unlikely to encode a functional protein; almost completely overlaps YNL090W/RHO2 which encodes a small GTPase of the Rho/Rac subfamily of Ras-like proteins Unknown Unknown Unknown
YLR168C YLR168C UPS2 hom Verified 0.793019453393076 0.213883244442245 no 1022 0.214490197993614 757 NA FT LIPID METABOLISM|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial protein involved in phospholipid metabolism; localizes to the intermembrane space; has a role in regulation of phospholipid metabolism by inhibiting conversion of phosphatidylethanolamine to phosphatidylcholine; null mutant has defects in mitochondrial morphology; similar to Ups1p, Ups3p and to human PRELI cristae formation|Unknown|phosphatidylethanolamine metabolic process|cardiolipin metabolic process molecular_function extrinsic to mitochondrial inner membrane|mitochondrion|mitochondrial intermembrane space
YGL153W YGL153W PEX14 hom Verified 0.79280334344789 0.213946204121324 no 1023 0.212308817116709 731 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PEROXISOME ORGANIZATION Peroxisomal membrane peroxin that is a central component of the peroxisomal protein import machinery; interacts with both PTS1 (Pex5p) and PTS2 (Pex7p), peroxisomal matrix protein signal recognition factors and membrane receptor Pex13p protein import into peroxisome matrix, docking protein binding, bridging peroxisomal membrane
YJL186W YJL186W MNN5 hom Verified 0.792311915987833 0.214089412677796 no 1024 0.189789649927419 681 NA FT CARBOHYDRATE METABOLISM GOLGI APPARATUS Alpha-1,2-mannosyltransferase, responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment protein glycosylation alpha-1,2-mannosyltransferase activity Golgi apparatus
YFR017C YFR017C IGD1 hom Verified 0.791921248083176 0.214203298339211 no 1025 0.218076364260793 712 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Cytoplasmic protein that inhibits Gdb1p glycogen debranching activity; required for normal intracellular accumulation of glycogen; phosphorylated in vivo; expression increases during wine fermentation; protein abundance increases in response to DNA replication stress; IGD1 has a paralog, YOL024W, that arose from the whole genome duplication negative regulation of glycogen catabolic process enzyme inhibitor activity cytoplasm
YJL028W YJL028W YJL028W hom Verified 0.79174669666008 0.214254194135519 no 1026 0.172789055074884 558 NA Protein of unknown function; may interact with ribosomes, based on co-purification experiments biological_process molecular_function ribosome
YOR268C_p YOR268C YOR268C hom Uncharacterized 0.791381646966183 0.214360658256655 no 1027 0.168005624406927 548 NA Putative protein of unknown function; sporulation is abnormal in homozygous diploid; YOR268C is not an essential gene biological_process molecular_function cellular_component
YEL059C-A YEL059C-A SOM1 hom Verified 0.789070035423227 0.215035537071411 no 1028 0.201403490367205 674 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs proteolysis|mitochondrial respiratory chain complex assembly endopeptidase activity mitochondrial inner membrane peptidase complex|mitochondrial inner membrane
YDR385W YDR385W EFT2 hom Verified 0.78886827811199 0.215094498934499 no 1029 0.204987818027437 711 NA FT TRANSLATION|NUCLEOTIDE METABOLISM RIBOSOME Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT2 has a paralog, EFT1, that arose from the whole genome duplication translational elongation|positive regulation of translational elongation translation elongation factor activity ribosome
YCL010C YCL010C SGF29 hom Verified 0.788101817539275 0.215318576077536 no 1030 0.199943442904252 688 NA FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS HISTONE ACETYLTRANSFERASE Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes; HAT/Core module also contains Gcn5p, Ngg1p, and Ada2p; binds methylated histone H3K4; involved in transcriptional regulation through SAGA and TBP recruitment to target promoters and H3 acetylation histone H3-K14 acetylation|cellular protein complex localization|histone H3-K18 acetylation|cellular protein localization|histone H3-K9 acetylation|positive regulation of transcription from RNA polymerase II promoter methylated histone residue binding|RNA polymerase II transcription factor recruiting transcription factor activity Ada2/Gcn5/Ada3 transcription activator complex|SAGA complex
YNL246W YNL246W VPS75 hom Verified 0.788065949403698 0.21532906555571 no 1031 0.238237708589606 839 NA FT PROTEIN LOCALIZATION|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME NAP family histone chaperone; binds to histones and Rtt109p, stimulating histone acetyltransferase activity; possesses nucleosome assembly activity in vitro; proposed role in vacuolar protein sorting and in double-strand break repair; protein abundance increases in response to DNA replication stress double-strand break repair via nonhomologous end joining|nucleosome assembly|positive regulation of histone acetylation histone binding|acetyltransferase activator activity chromatin|nucleus
YER002W YER002W NOP16 hom Verified 0.788010233791624 0.215345359928915 no 1032 0.230258874514549 770 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis ribosomal large subunit biogenesis molecular_function nucleolus|nucleus|preribosome, large subunit precursor
YHR139C YHR139C SPS100 hom Verified 0.787085463528893 0.215615919145158 no 1033 0.226464024270416 792 NA FT KETONE METABOLISM|CELL CYCLE|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall; expression also induced in cells treated with the mycotoxin patulin ascospore wall assembly molecular_function ascospore wall
YML116W YML116W ATR1 hom Verified 0.786709980710015 0.215725830059368 no 1034 0.168619128897619 535 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Multidrug efflux pump of the major facilitator superfamily; required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; ATR1 has a paralog, YMR279C, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress borate transport|drug transmembrane transport drug transmembrane transporter activity|borate transmembrane transporter activity integral to membrane|plasma membrane|vacuole
YKL009W YKL009W MRT4 hom Verified 0.786534878434003 0.21577709690609 no 1035 0.230918781353493 785 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolus nuclear-transcribed mRNA catabolic process|ribosomal large subunit assembly|ribosomal large subunit biogenesis|rRNA processing LSU rRNA binding nucleoplasm|nucleolus|nucleus|preribosome, large subunit precursor
YAR020C YAR020C PAU7 hom Verified 0.786429876508809 0.215807842997783 no 1036 0.216864649420224 715 NA Member of the seripauperin multigene family, active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme biological_process molecular_function cellular_component
YLR420W YLR420W URA4 hom Verified 0.78610680541107 0.215902458840155 no 1037 0.22687587696828 760 NA FT NUCLEOTIDE METABOLISM NUCLEUS Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate 'de novo' pyrimidine nucleobase biosynthetic process|pyrimidine nucleotide biosynthetic process dihydroorotase activity nucleus|cytoplasm
YCL037C YCL037C SRO9 hom Verified 0.785206153448906 0.216166354106357 no 1038 0.250043588163286 873 NA FT TRANSLATION Cytoplasmic RNA-binding protein; associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif; SRO9 has a paralog, SLF1, that arose from the whole genome duplication cytoplasmic translation RNA binding polysome
YPR045C YPR045C THP3 hom Verified 0.785188436360067 0.216171547169457 no 1039 0.209200365288129 735 NA FT RNA PROCESSING NUCLEUS|CHROMOSOME Protein that forms a complex with Csn12p that is recruited to transcribed genes and may have a role in transcription elongation; possibly involved in splicing based on pre-mRNA accumulation defect for many intron-containing genes mRNA splicing, via spliceosome molecular_function nucleus|transcriptionally active chromatin
YHL002W YHL002W HSE1 hom Verified 0.784745769346068 0.216301320927733 no 1040 0.228290936027442 732 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes late endosome to vacuole transport|protein targeting to vacuole ubiquitin binding endosome|ESCRT-0 complex
YER180C-A YER180C-A SLO1 hom Verified 0.784521350895522 0.216367129423573 no 1041 0.234039444517159 833 NA FT PROTEIN LOCALIZATION Protein interacting with Arl3p, which is a GTPase of the Ras superfamily involved in vesicle-tethering at the Golgi; putative ortholog of human SCOCO intracellular protein transport small GTPase regulator activity cytoplasm
YPR038W_d YPR038W IRC16 hom Dubious 0.784200236633708 0.216461313163397 no 1042 0.207346361163422 727 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene YPR037C; null mutant displays increased levels of spontaneous Rad52p foci Unknown Unknown Unknown
YMR182W-A_p YMR182W-A YMR182W-A hom Uncharacterized 0.783687402192384 0.21661177817456 no 1043 0.181377725250276 605 NA Putative protein of unknown function biological_process molecular_function cellular_component
YOR316C YOR316C COT1 hom Verified 0.783312703372417 0.216721752601313 no 1044 0.23224665386628 776 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium; protein abundance increases in response to DNA replication stress; COT1 has a paralog, ZRC1, that arose from the whole genome duplication cellular zinc ion homeostasis|cobalt ion transport|zinc ion transport cobalt ion transmembrane transporter activity|zinc ion transmembrane transporter activity|inorganic cation transmembrane transporter activity mitochondrion|integral to membrane|fungal-type vacuole
YOL013W-A_p YOL013W-A YOL013W-A hom Uncharacterized 0.783057281945171 0.216796737514536 no 1045 0.215298729179593 726 NA Putative protein of unknown function; identified by SAGE biological_process molecular_function integral to membrane
YHR097C_p YHR097C YHR097C hom Uncharacterized 0.781147189994597 0.217357964883426 no 1046 0.2116974601248 730 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus biological_process molecular_function nucleus|cytoplasm
YKL163W YKL163W PIR3 hom Verified 0.780472373827781 0.217556441205737 no 1047 0.199742297743523 656 NA FT CELL WALL ORG/BIOGENESIS O-glycosylated covalently-bound cell wall protein; required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway; PIR3 has a paralog, HSP150, that arose from the whole genome duplication fungal-type cell wall organization structural constituent of cell wall fungal-type cell wall
YPL067C_p YPL067C YPL067C hom Uncharacterized 0.780017184573596 0.217690380113184 no 1048 0.204513088920649 656 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL067C is not an essential gene biological_process molecular_function cytoplasm
YDL216C YDL216C RRI1 hom Verified 0.779230307717307 0.217922029885217 no 1049 0.224696847988348 789 NA FT SIGNALING|PROTEOLYSIS NUCLEUS Catalytic subunit of the COP9 signalosome (CSN) complex that acts as an isopeptidase in cleaving the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; metalloendopeptidase involved in the adaptation to pheromone signaling adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|cullin deneddylation metalloendopeptidase activity signalosome
YCR001W_d YCR001W YCR001W hom Dubious 0.779105831943546 0.217958687498447 no 1050 0.19246776692524 668 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR001W is not an essential gene Unknown Unknown Unknown
YHR044C YHR044C DOG1 hom Verified 0.779101171863007 0.21796005994241 no 1051 0.196894805385029 675 NA FT CARBOHYDRATE METABOLISM 2-deoxyglucose-6-phosphate phosphatase; paralogous to DOG2; member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed, in vivo substrate has not yet been identified glucose metabolic process 2-deoxyglucose-6-phosphatase activity cellular_component
YOL009C YOL009C MDM12 hom Verified 0.779097710243348 0.217961079429946 no 1052 0.216354517849159 760 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION Mitochondrial outer membrane protein, required for transmission of mitochondria to daughter cells; component of the ERMES complex that links the ER to mitochondria; may influence import and assembly of outer membrane beta-barrel proteins mitochondrion inheritance|mitochondrion organization|protein import into mitochondrial outer membrane|phospholipid transport molecular_function mitochondrial outer membrane|mitochondrion|ERMES complex
YHR167W YHR167W THP2 hom Verified 0.777732241413059 0.21836344039669 no 1053 0.23511845113154 827 NA FT TRANSCRIPTION FROM RNA POL II|RNA LOCALIZATION NUCLEUS Subunit of the THO complex, which connects transcription elongation and mitotic recombination, and of the TREX complex, which is recruited to activated genes and couples transcription to mRNA export; involved in telomere maintenance mRNA export from nucleus|transcription elongation from RNA polymerase II promoter|DNA recombination nucleic acid binding THO complex part of transcription export complex|nucleoplasmic THO complex
YMR194W YMR194W RPL36A hom Verified 0.776903712291614 0.218607790445325 no 1054 0.203568080707637 692 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L36A; N-terminally acetylated; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36A has a paralog, RPL36B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YJL100W YJL100W LSB6 hom Verified 0.772483043538723 0.21991419299261 no 1055 0.236093688033565 822 NA FT LIPID METABOLISM PLASMA MEMBRANE Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization phosphatidylinositol phosphorylation 1-phosphatidylinositol 4-kinase activity fungal-type vacuole membrane|plasma membrane|cytoplasm
YPL001W YPL001W HAT1 hom Verified 0.770829977839159 0.220403857940877 no 1056 0.23721553206135 822 NA FT CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING NUCLEUS HISTONE ACETYLTRANSFERASE Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A, to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair histone acetylation|chromatin silencing at telomere histone acetyltransferase activity|histone binding histone acetyltransferase complex|nucleus|cytoplasm
YBR203W YBR203W COS111 hom Verified 0.770515685567458 0.220497027077333 no 1057 0.262165842240686 876 NA FT SIGNALING MITOCHONDRION Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies signal transduction molecular_function mitochondrion
YDR260C YDR260C SWM1 hom Verified 0.770264512112089 0.220571501427365 no 1058 0.225025162647754 770 NA FT CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|PROTEOLYSIS NUCLEUS UBIQUITIN LIGASE COMPLEX Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation ascospore wall assembly|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|regulation of mitotic metaphase/anaphase transition|protein ubiquitination molecular_function anaphase-promoting complex|nucleus
YER059W YER059W PCL6 hom Verified 0.769601673589291 0.220768105983241 no 1059 0.204789033806298 718 NA FT CELL CYCLE|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Pho85p cyclin of the Pho80p subfamily; forms the major Glc8p kinase together with Pcl7p and Pho85p; involved in the control of glycogen storage by Pho85p; stabilized by Elongin C binding regulation of glycogen catabolic process|regulation of glycogen biosynthetic process cyclin-dependent protein kinase regulator activity cyclin-dependent protein kinase holoenzyme complex
YFR022W YFR022W ROG3 hom Verified 0.769556976662608 0.220781367150944 no 1060 0.194581334864182 673 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION Protein that binds the ubiquitin ligase Rsp5p via its 2 PY motifs; mutation suppresses the temperature sensitivity of an mck1 rim11 double mutant; proposed to regulate the endocytosis of plasma membrane proteins; ROG3 has a paralog, ROD1, that arose from the whole genome duplication ubiquitin-dependent endocytosis ubiquitin protein ligase binding cellular_component
YDL001W YDL001W RMD1 hom Verified 0.769040694259208 0.220934576460427 no 1061 0.212911857781689 757 NA FT CELL CYCLE Cytoplasmic protein required for sporulation biological_process molecular_function cytoplasm
YNL195C_p YNL195C YNL195C hom Uncharacterized 0.768651716076601 0.221050047813842 no 1062 0.239661115210909 845 NA FT MITOCHONDRION Putative protein of unknown function; shares a promoter with YNL194C; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YNR064C YNR064C YNR064C hom Verified 0.768489076849085 0.221098338835619 no 1063 0.214425885773334 785 NA Epoxide hydrolase, member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides response to toxin epoxide hydrolase activity cellular_component
YJR001W YJR001W AVT1 hom Verified 0.768125550369531 0.221206299348724 no 1064 0.257092099129794 884 NA FT VACUOLAR TRANSPORT Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters amino acid transport|vacuolar transport transporter activity|L-glutamine transmembrane transporter activity|L-isoleucine transmembrane transporter activity|L-tyrosine transmembrane transporter activity fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YMR139W YMR139W RIM11 hom Verified 0.767497954152345 0.221392754551384 no 1065 0.178443214708881 605 NA FT PROTEOLYSIS|PROTEIN PHOSPHORYLATION Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress proteolysis|ascospore formation|protein phosphorylation|response to stress protein serine/threonine kinase activity|protein kinase activity cytoplasm
YIL149C YIL149C MLP2 hom Verified 0.764916563860445 0.222160614974484 no 1066 0.201404893913611 673 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CYTOSKELETON ORGANIZATION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION|CYTOSKELETON Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved in the Tel1p pathway that controls telomere length poly(A)+ mRNA export from nucleus|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|regulation of transcription, DNA-dependent|telomere tethering at nuclear periphery|spindle pole body organization|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery ribonucleoprotein complex binding nucleoplasm|nuclear envelope|mitochondrion|ribonucleoprotein complex|integral to membrane|spindle pole body
YDL065C YDL065C PEX19 hom Verified 0.764292669273437 0.222346426484568 no 1067 0.225093132768445 761 NA FT PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Chaperone and import receptor for newly-synthesized class I PMPs; binds peroxisomal membrane proteins (PMPs) in the cytoplasm and delivers them to the peroxisome for subsequent insertion into the peroxisomal membrane; interacts with Myo2p and contributes to peroxisome partitioning protein stabilization|protein import into peroxisome membrane|peroxisome inheritance|ER-dependent peroxisome organization|protein exit from endoplasmic reticulum peroxisome membrane targeting sequence binding|protein binding cytosol|peroxisomal membrane|endoplasmic reticulum
YDR378C YDR378C LSM6 hom Verified 0.764127927658278 0.222395505475204 no 1068 0.235724318819595 830 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA nuclear-transcribed mRNA catabolic process|mRNA splicing, via spliceosome|maturation of SSU-rRNA RNA binding U6 snRNP|nucleolus|small nucleolar ribonucleoprotein complex|U4/U6 x U5 tri-snRNP complex|cytoplasmic mRNA processing body
YEL017W YEL017W GTT3 hom Verified 0.76348441048609 0.222587278064625 no 1069 0.204720025617895 714 NA FT ENDOMEMBRANE SYSTEM|NUCLEUS Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery biological_process molecular_function cellular_component
YJL048C YJL048C UBX6 hom Verified 0.762815860338318 0.222786610468716 no 1070 0.209496798313636 712 NA FT PROTEOLYSIS NUCLEUS UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p, transcription is repressed when cells are grown in media containing inositol and choline; UBX6 has a paralog, UBX7, that arose from the whole genome duplication sporulation resulting in formation of a cellular spore|ubiquitin-dependent protein catabolic process molecular_function nucleus
YPL185W_d YPL185W YPL185W hom Dubious 0.762621755671997 0.222844503036119 no 1071 0.231202063836245 754 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C Unknown Unknown Unknown
YDR181C YDR181C SAS4 hom Verified 0.76239317409596 0.222912689481856 no 1072 0.264770015909899 905 NA FT CHROMATIN ORGANIZATION|PROTEOLYSIS|GENE SILENCING NUCLEUS|CHROMOSOME HISTONE ACETYLTRANSFERASE Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p chromatin silencing at telomere acetyltransferase activity|histone acetyltransferase activity nuclear chromatin|SAS acetyltransferase complex|nuclear chromosome, telomeric region
YLR183C YLR183C TOS4 hom Verified 0.761946448840244 0.223045983029033 no 1073 0.226126943782139 777 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION|CHROMOSOME Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; expression is periodic and peaks in G1; relative distribution to the nucleus increases upon DNA replication stress; TOS4 has a paralog, PLM2, that arose from the whole genome duplication response to DNA damage stimulus chromatin binding nuclear chromatin|Rpd3L-Expanded complex|mitochondrion|nucleus|cytoplasm
YBR297W YBR297W MAL33 hom Verified 0.761916606358389 0.223054889023489 no 1074 0.22377616383246 781 NA FT TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM NUCLEUS MAL-activator protein, part of complex locus MAL3; nonfunctional in genomic reference strain S288C cellular carbohydrate metabolic process|regulation of transcription, DNA-dependent sequence-specific DNA binding transcription factor activity nucleus
YDR158W YDR158W HOM2 hom Verified 0.761826529751855 0.223081772122928 no 1075 0.252642063110755 877 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS NUCLEUS Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis methionine biosynthetic process|threonine biosynthetic process|homoserine biosynthetic process aspartate-semialdehyde dehydrogenase activity nucleus|plasma membrane|cytoplasm
YJL149W YJL149W DAS1 hom Verified 0.76146449022027 0.22318984036863 no 1076 0.23608432132346 831 NA FT PROTEOLYSIS UBIQUITIN LIGASE COMPLEX Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity|protein binding, bridging SCF ubiquitin ligase complex
YBR089C-A YBR089C-A NHP6B hom Verified 0.761321938790634 0.223232399928229 no 1077 0.193919412388615 639 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME High-mobility group (HMG) protein, binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Ap; homologous to mammalian HMGB1 and HMGB2; NHP6B has a paralog, NHP6A, that arose from the whole genome duplication RNA polymerase III transcriptional preinitiation complex assembly|chromatin remodeling|transcription from RNA polymerase II promoter nucleosome binding|DNA binding, bending|sequence-specific DNA binding nucleus
YPR201W YPR201W ARR3 hom Verified 0.760983570294804 0.223333440307619 no 1078 0.207870445159042 747 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Plasma membrane metalloid/H+ antiporter; transports arsenite and antimonite; required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite arsenite transport|antimonite transport antiporter activity|arsenite transmembrane transporter activity|antimonite transmembrane transporter activity integral to membrane|plasma membrane
YIL060W_p YIL060W YIL060W hom Uncharacterized 0.760706835683573 0.22341609550601 no 1079 0.242776937822307 859 NA Putative protein of unknown function; mutant accumulates less glycogen than does wild type; null mutation results in a decrease in plasma membrane electron transport; YIL060W is not an essential gene biological_process molecular_function cellular_component
YIL125W YIL125W KGD1 hom Verified 0.760174668766146 0.223575092228333 no 1080 0.237528844528666 780 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA tricarboxylic acid cycle|2-oxoglutarate metabolic process oxoglutarate dehydrogenase (succinyl-transferring) activity mitochondrial nucleoid|mitochondrion|mitochondrial matrix|mitochondrial oxoglutarate dehydrogenase complex
YDR142C YDR142C PEX7 hom Verified 0.758347865113854 0.224121379869723 no 1081 0.246956322574305 799 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PEROXISOME ORGANIZATION Peroxisomal signal receptor for the N-terminal nonapeptide signal (PTS2) of peroxisomal matrix proteins; WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodysplasia punctata (RCDP) protein import into peroxisome matrix, docking peroxisome matrix targeting signal-2 binding cytosol|peroxisome
YGL212W YGL212W VAM7 hom Verified 0.757495941596397 0.224376398194052 no 1082 0.238727736119605 808 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION Vacuolar SNARE protein; functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding; SNAP-25 homolog; protein abundance increases in response to DNA replication stress piecemeal microautophagy of nucleus|vacuole fusion, non-autophagic|vesicle fusion SNAP receptor activity|phosphatidylinositol-3-phosphate binding SNARE complex|fungal-type vacuole membrane
YGL146C_p YGL146C RRT6 hom Uncharacterized 0.757167215434916 0.224474844469576 no 1083 0.198338065912503 648 NA Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins biological_process molecular_function membrane
YIR025W YIR025W MND2 hom Verified 0.75667175148405 0.224623271358761 no 1084 0.236941295353464 809 NA FT CELL CYCLE|CELL DIVISION|PROTEOLYSIS|CHROMOSOME SEGREGATION NUCLEUS UBIQUITIN LIGASE COMPLEX Subunit of the anaphase-promoting complex (APC); necessary for maintaining sister chromatid cohesion in prophase I of meiosis by inhibiting premature ubiquitination and subsequent degradation of substrates by the APC(Ama1) ubiquitin ligase anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|reciprocal meiotic recombination|regulation of mitotic metaphase/anaphase transition|protein ubiquitination|mitotic sister chromatid segregation molecular_function nucleus|anaphase-promoting complex
YJL175W_d YJL175W YJL175W hom Dubious 0.756485548750917 0.224679066784079 no 1085 0.213956887570509 679 NA Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor Unknown Unknown Unknown
YLR251W YLR251W SYM1 hom Verified 0.75645045356519 0.224689583894667 no 1086 0.212346875858967 703 NA FT MITOCHONDRION Protein required for ethanol metabolism; induced by heat shock and localized to the inner mitochondrial membrane; homologous to mammalian peroxisomal membrane protein Mpv17 ethanol metabolic process molecular_function mitochondrion|integral to membrane|mitochondrial inner membrane
YHR076W YHR076W PTC7 hom Verified 0.755843504446594 0.22487151485867 no 1087 0.241954976155025 816 NA FT ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION Type 2C protein phosphatase (PP2C); alternatively spliced to create two mRNA isoforms; protein from spliced form localizes to the mitochondria while the one from the unspliced form is localized to the nuclear envelope biological_process protein serine/threonine phosphatase activity nuclear envelope|mitochondrion
YIR020W-A_d YIR020W-A YIR020W-A hom Dubious 0.753762088721048 0.225496046088912 no 1088 0.238709875753598 829 NA Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data Unknown Unknown Unknown
YML099C YML099C ARG81 hom Verified 0.75345566813574 0.225588070779253 no 1089 0.223966661905333 789 NA FT VESICLE-MEDIATED TRANSPORT|TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type, involved in the regulation of arginine-responsive genes; acts with Arg80p and Arg82p arginine metabolic process|negative regulation of calcium ion-dependent exocytosis transcription cofactor activity nucleus
YOR199W_d YOR199W YOR199W hom Dubious 0.752932306649944 0.225745296624001 no 1090 0.249989676772211 829 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOR079C YOR079C ATX2 hom Verified 0.752240525211858 0.225953213500215 no 1091 0.186008009282428 615 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Golgi membrane protein involved in manganese homeostasis; overproduction suppresses the sod1 (copper, zinc superoxide dismutase) null mutation cellular manganese ion homeostasis manganese ion transmembrane transporter activity integral to membrane|Golgi membrane
YBR093C YBR093C PHO5 hom Verified 0.751944519678041 0.226042211868308 no 1092 0.215083127104174 732 NA FT RESPONSE TO NUTRIENT LEVELS Repressible acid phosphatase (1 of 3) that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2 cellular response to phosphate starvation|phosphate-containing compound metabolic process|regulation of cell size nucleoside-triphosphate diphosphatase activity|nucleoside-triphosphatase activity|acid phosphatase activity fungal-type cell wall|cell wall-bounded periplasmic space
YDL123W YDL123W SNA4 hom Verified 0.751677349821254 0.226122557381399 no 1093 0.243364302562157 790 NA Protein of unknown function, localized to the vacuolar outer membrane; predicted to be palmitoylated biological_process molecular_function fungal-type vacuole lumen|fungal-type vacuole membrane
YML057W YML057W CMP2 hom Verified 0.749243529422726 0.226855218596451 no 1094 0.190449798530869 638 NA FT SIGNALING|ION HOMEOSTASIS|ION HOMEOSTASIS Calcineurin A; one isoform (the other is CNA1) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1 adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|cellular ion homeostasis calcium-dependent protein serine/threonine phosphatase activity calcineurin complex|cytoplasm
YER066W_p YER066W RRT13 hom Uncharacterized 0.747960769313055 0.227241910483595 no 1095 0.192727644810876 680 NA Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription biological_process molecular_function cellular_component
YDR445C_d YDR445C YDR445C hom Dubious 0.747582855966979 0.227355904396162 no 1096 0.250712768325777 838 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPL026C YPL026C SKS1 hom Verified 0.747376317379954 0.227418218379784 no 1097 0.166091112579322 573 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN PHOSPHORYLATION NUCLEUS Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway glucose transport|protein phosphorylation|response to glucose stimulus|positive regulation of transcription from RNA polymerase II promoter protein serine/threonine kinase activity|protein kinase activity nucleus|cytoplasm
YLR107W YLR107W REX3 hom Verified 0.747090282582378 0.227504532753224 no 1098 0.212544921829823 727 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS RNA exonuclease; required for maturation of the RNA component of RNase MRP; functions redundantly with Rnh70p and Rex2p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases U5 snRNA 3'-end processing|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ncRNA 3'-end processing 3'-5'-exoribonuclease activity|3'-5' exonuclease activity nucleus|cytoplasm
YBR208C YBR208C DUR1,2 hom Verified 0.745889266624411 0.227867154785214 no 1099 0.214684006332946 728 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Urea amidolyase; contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; protein abundance increases in response to DNA replication stress allantoin catabolic process|urea catabolic process urea carboxylase activity|allophanate hydrolase activity cytoplasm
YGL159W_p YGL159W YGL159W hom Uncharacterized 0.745715059989651 0.227919779884757 no 1100 0.243526127026911 861 NA Putative protein of unknown function; deletion mutant has no detectable phenotype biological_process molecular_function cellular_component
YNR014W_p YNR014W YNR014W hom Uncharacterized 0.745675319584862 0.227931785797197 no 1101 0.243392154792314 821 NA Putative protein of unknown function; expression is cell-cycle regulated, Azf1p-dependent, and heat-inducible; YNR014W has a paralog, YMR206W, that arose from the whole genome duplication biological_process molecular_function cytoplasm
YDR322W YDR322W MRPL35 hom Verified 0.745659432631298 0.227936585479797 no 1102 0.247963794988923 836 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YCR069W YCR069W CPR4 hom Verified 0.7454104683663 0.228011808676978 no 1103 0.212081174265685 750 NA Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway biological_process peptidyl-prolyl cis-trans isomerase activity membrane
YBR268W YBR268W MRPL37 hom Verified 0.744080754382679 0.228413810880231 no 1104 0.271399551452028 942 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YBR058C YBR058C UBP14 hom Verified 0.743549324683953 0.228574585253607 no 1105 0.220907270141705 764 NA FT KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS NUCLEUS Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase T protein deubiquitination|negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process ubiquitin-specific protease activity cytoplasm
YGR288W YGR288W MAL13 hom Verified 0.743155652911665 0.228693724446705 no 1106 0.228515542919441 787 NA FT TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM NUCLEUS MAL-activator protein, part of complex locus MAL1; nonfunctional in genomic reference strain S288C cellular carbohydrate metabolic process|regulation of transcription, DNA-dependent sequence-specific DNA binding transcription factor activity nucleus
YLR246W YLR246W ERF2 hom Verified 0.743080195516403 0.228716564541561 no 1107 0.204498522540782 681 NA FT PROTEIN LOCALIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Subunit of a palmitoyltransferase, composed of Erf2p and Shr5p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; mutants partially mislocalize Ras2p to the vacuole protein targeting to membrane|protein palmitoylation palmitoyltransferase activity endoplasmic reticulum palmitoyltransferase complex|integral to endoplasmic reticulum membrane|integral to membrane
YER046W-A_d YER046W-A YER046W-A hom Dubious 0.741151341896909 0.229300841208821 no 1108 0.218796550081938 780 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YMR151W_d YMR151W YIM2 hom Dubious 0.740247970742171 0.229574772401723 no 1109 0.222084912913226 730 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1 Unknown Unknown Unknown
YMR132C_p YMR132C JLP2 hom Uncharacterized 0.739750188282649 0.229725794367748 no 1110 0.197092169527724 637 NA Protein of unknown function, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein) biological_process molecular_function cytoplasm
YGR256W YGR256W GND2 hom Verified 0.739015603869571 0.229948761158063 no 1111 0.215157668729402 751 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS 6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone; GND2 has a paralog, GND1, that arose from the whole genome duplication pentose-phosphate shunt, oxidative branch phosphogluconate dehydrogenase (decarboxylating) activity cytosol|plasma membrane
YMR250W YMR250W GAD1 hom Verified 0.73814857783011 0.230212083445747 no 1112 0.237671024285204 839 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|RESPONSE TO OXIDATIVE STRESS Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress cellular response to oxidative stress|glutamate catabolic process calmodulin binding|glutamate decarboxylase activity cytoplasm
YPL216W_p YPL216W YPL216W hom Uncharacterized 0.738037449182684 0.230245846236618 no 1113 0.230471837635655 787 NA FT CHROMATIN ORGANIZATION NUCLEUS Putative protein of unknown function; YPL216W is not an essential gene biological_process molecular_function cellular_component
YNL183C YNL183C NPR1 hom Verified 0.737053990813161 0.230544758444724 no 1114 0.213795950556023 754 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION GOLGI APPARATUS|PLASMA MEMBRANE Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex regulation of transmembrane transporter activity|regulation of nitrogen utilization|protein phosphorylation|negative regulation of endocytosis protein serine/threonine kinase activity Golgi apparatus|plasma membrane|cytoplasm
YPR099C_d YPR099C YPR099C hom Dubious 0.736957960105139 0.230573957623309 no 1115 0.226262621919687 788 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL51/YPR100W Unknown Unknown Unknown
YKL176C YKL176C LST4 hom Verified 0.736907052896629 0.230589437350455 no 1116 0.256614449982125 861 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface intracellular protein transport|vesicle-mediated transport|protein transport|Golgi to plasma membrane transport protein transporter activity vesicle coat
YDR200C YDR200C VPS64 hom Verified 0.73647431539438 0.230721046454342 no 1117 0.278755222409714 951 NA FT PROTEIN LOCALIZATION|CELL CYCLE|SIGNALING|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein required for cytoplasm to vacuole targeting of proteins; forms a complex with Far3p and Far7p to Far11p involved in recovery from pheromone-induced cell cycle arrest; mutant has increased aneuploidy tolerance re-entry into mitotic cell cycle after pheromone arrest|protein targeting to vacuole molecular_function endoplasmic reticulum membrane|cytoplasm
YLR072W_p YLR072W YLR072W hom Uncharacterized 0.736443783707085 0.230730333686521 no 1118 0.234820059782918 788 NA FT ENDOMEMBRANE SYSTEM Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YLR072W is not an esssential gene biological_process molecular_function cytoplasm
YGL194C YGL194C HOS2 hom Verified 0.736069648876262 0.230844156244936 no 1119 0.218987837256908 767 NA FT CELL CYCLE|CHROMATIN ORGANIZATION|SIGNALING NUCLEUS|CHROMOSOME Histone deacetylase and subunit of Set3 and Rpd3L complexes; required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; co-localizes with Cmr1p in nuclear foci in response to DNA damage by MMS negative regulation of meiosis|chromatin organization|regulation of transcription, DNA-dependent|positive regulation of stress-activated MAPK cascade|histone deacetylation NAD-independent histone deacetylase activity|NAD-dependent histone deacetylase activity Rpd3L-Expanded complex|Set3 complex
YOR317W YOR317W FAA1 hom Verified 0.735370797055616 0.2310568510007 no 1120 0.232512996350137 813 NA FT KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM MITOCHONDRION Long chain fatty acyl-CoA synthetase; activates imported fatty acids with a preference for C12:0-C16:0 chain lengths; functions in long chain fatty acid import; accounts for most acyl-CoA synthetase activity; localized to lipid particles; involved in sphingolipid-to-glycerolipid metabolism; forms ER foci upon DNA replication stress; FAA1 has a paralog, FAA4, that arose from the whole genome duplication long-chain fatty acid transport|long-chain fatty-acyl-CoA metabolic process long-chain fatty acid-CoA ligase activity mitochondrial outer membrane|mitochondrion|lipid particle|plasma membrane
YDR281C YDR281C PHM6 hom Verified 0.735146413435088 0.23112516509037 no 1121 0.251312892009144 849 NA Protein of unknown function, expression is regulated by phosphate levels biological_process molecular_function fungal-type vacuole
YGL240W YGL240W DOC1 hom Verified 0.73504544340347 0.23115590931657 no 1122 0.240923251491571 842 NA FT CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION|PROTEOLYSIS NUCLEUS|MITOCHONDRION UBIQUITIN LIGASE COMPLEX Processivity factor required for the ubiquitination activity of the anaphase promoting complex (APC), mediates the activity of the APC by contributing to substrate recognition; involved in cyclin proteolysis; contains a conserved DOC1 homology domain activation of mitotic anaphase-promoting complex activity|chromatin assembly|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cyclin catabolic process enzyme regulator activity|mitotic anaphase-promoting complex activity mitochondrion|anaphase-promoting complex
YML038C YML038C YMD8 hom Verified 0.734159025108733 0.231425911537758 no 1123 0.23360345808048 775 NA FT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Putative nucleotide sugar transporter, has similarity to Vrg4p UDP-glucose transport|nucleotide-sugar transport nucleotide-sugar transmembrane transporter activity COPI-coated vesicle|integral to membrane
YKR030W YKR030W GMH1 hom Verified 0.734044762794588 0.231460728527465 no 1124 0.211710114068461 744 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Golgi membrane protein of unknown function, interacts with Gea1p and Gea2p; required for localization of Gea2p; computational analysis suggests a possible role in either cell wall synthesis or protein-vacuolar targeting transport molecular_function integral to membrane|integral to Golgi membrane
YGR151C_d YGR151C YGR151C hom Dubious 0.733725874365653 0.231557912802944 no 1125 0.229937760629847 797 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF RSR1/BUD1/YGR152C; relative distribution to the nucleus increases upon DNA replication stress Unknown Unknown Unknown
YHR106W YHR106W TRR2 hom Verified 0.733111254466599 0.231745288202841 no 1126 0.192668927351327 645 NA FT OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS MITOCHONDRION Mitochondrial thioredoxin reductase; involved in protection against oxidative stress, required with Glr1p to maintain the redox state of Trx3p; contains active-site motif (CAVC) present in prokaryotic orthologs; binds NADPH and FAD; TRR2 has a paralog, TRR1, that arose from the whole genome duplication cellular response to oxidative stress|cell redox homeostasis thioredoxin-disulfide reductase activity mitochondrion
YJL183W YJL183W MNN11 hom Verified 0.733093314672129 0.231750758666555 no 1127 0.262425621839948 887 NA FT CARBOHYDRATE METABOLISM GOLGI APPARATUS Subunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p protein glycosylation alpha-1,6-mannosyltransferase activity alpha-1,6-mannosyltransferase complex
YDR514C YDR514C YDR514C hom Verified 0.731479192967352 0.232243254543729 no 1128 0.224161439524859 760 NA FT NUCLEUS|MITOCHONDRION Protein of unknown function that localizes to mitochondria; overexpression affects endocytic protein trafficking; YDR514C has a paralog, GFD2, that arose from the whole genome duplication biological_process molecular_function mitochondrion|nucleus
YBR196C-A_p YBR196C-A YBR196C-A hom Uncharacterized 0.73106525402548 0.232369648088505 no 1129 0.269490952161885 917 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YOL056W YOL056W GPM3 hom Verified 0.730953728346711 0.232403708266314 no 1130 0.230040941483882 801 NA FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event biological_process phosphoglycerate mutase activity|molecular_function cytosol
YLR020C YLR020C YEH2 hom Verified 0.730626237132448 0.232503740822345 no 1131 0.223985798968484 751 NA FT LIPID METABOLISM|CELL WALL ORG/BIOGENESIS PLASMA MEMBRANE Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism cell wall mannoprotein biosynthetic process|sterol metabolic process sterol esterase activity integral to membrane|plasma membrane
YML113W YML113W DAT1 hom Verified 0.729396332481276 0.232879630287821 no 1132 0.217649762051257 754 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS DNA binding protein that recognizes oligo(dA).oligo(dT) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; not essential for viability negative regulation of transcription from RNA polymerase II promoter AT DNA binding nucleus
YJL065C YJL065C DLS1 hom Verified 0.729359509800114 0.232890889418125 no 1133 0.261415355063779 888 NA FT GENE SILENCING NUCLEUS Subunit of ISW2/yCHRAC chromatin accessibility complex; ISW2/yCHRAC also includes Itc1p, Isw2p, and Dpb4p; involved in inheritance of telomeric silencing; DLS1 has a paralog, DPB3, that arose from the whole genome duplication chromatin silencing at telomere molecular_function chromatin accessibility complex|nucleus
YNL045W YNL045W LAP2 hom Verified 0.727220794482523 0.233545354814292 no 1134 0.218246438862254 752 NA FT KETONE METABOLISM|LIPID METABOLISM|PROTEOLYSIS NUCLEUS Leucyl aminopeptidase yscIV (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus cellular lipid metabolic process|protein catabolic process aminopeptidase activity|leukotriene-A4 hydrolase activity|epoxide hydrolase activity nucleus|cytoplasm
YOR087W YOR087W YVC1 hom Verified 0.726810813649592 0.233670928896824 no 1135 0.222875765016193 700 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Vacuolar cation channel, mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock cellular cation homeostasis voltage-gated ion channel activity|calcium activated cation channel activity|sodium channel activity|calcium channel activity|potassium channel activity fungal-type vacuole membrane|fungal-type vacuole
YMR238W YMR238W DFG5 hom Verified 0.726452324999397 0.233780761975411 no 1136 0.260197168859105 909 NA FT CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM PLASMA MEMBRANE Putative mannosidase, essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis in bud formation, involved in filamentous growth, homologous to Dcw1p pseudohyphal growth|fungal-type cell wall biogenesis|budding cell bud growth mannosidase activity anchored to plasma membrane
YOL057W YOL057W YOL057W hom Verified 0.726339189722642 0.23381543008771 no 1137 0.219784000400575 713 NA FT PROTEOLYSIS NUCLEUS Dipeptidyl-peptidase III; cleaves dipeptides from the amino terminus of target proteins; highly active on synthetic substrate Arg-Arg-2-naphthylamide; mammalian ortholog may be a biomarker for some cancers proteolysis dipeptidyl-peptidase activity nucleus|cytoplasm
YOL002C YOL002C IZH2 hom Verified 0.726299794221967 0.233827502743923 no 1138 0.231063968506773 804 NA FT KETONE METABOLISM|LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc response to zinc ion|cellular zinc ion homeostasis|response to toxin|cellular lipid metabolic process protein binding|metal ion binding integral to membrane|plasma membrane|membrane
YIL067C_p YIL067C YIL067C hom Uncharacterized 0.725743680885492 0.233997959186454 no 1139 0.238355055317793 804 NA Uncharacterized protein of unknown function biological_process molecular_function integral to membrane|fungal-type vacuole
YGL135W YGL135W RPL1B hom Verified 0.724423790285054 0.234402799359294 no 1140 0.258697843172642 898 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L1B; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1B has a paralog, RPL1A, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YPR194C YPR194C OPT2 hom Verified 0.724266776893108 0.234450984684679 no 1141 0.230270748433206 805 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION PLASMA MEMBRANE Oligopeptide transporter; member of the OPT family, with potential orthologs in S. pombe and C. albicans; also plays a role in formation of mature vacuoles oligopeptide transport|vacuole fusion, non-autophagic oligopeptide transporter activity integral to membrane|integral to plasma membrane
YLR090W YLR090W XDJ1 hom Verified 0.723695400194414 0.234626378858293 no 1142 0.251364499044172 844 NA FT NUCLEUS|MITOCHONDRION Chaperone with a role in facilitating mitochondrial protein import; ascomycete-specific member of the DnaJ-like family, closely related to Ydj1p; predicted to be C-terminally prenylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies protein folding chaperone binding mitochondrion|integral to mitochondrial outer membrane|nucleus
YKR058W YKR058W GLG1 hom Verified 0.723372400545957 0.234725561403882 no 1143 0.221887187158246 760 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG1 has a paralog, GLG2, that arose from the whole genome duplication glycogen biosynthetic process glycogenin glucosyltransferase activity cellular_component
YPR198W YPR198W SGE1 hom Verified 0.722966750449667 0.234850156008311 no 1144 0.276530403247456 965 NA FF|FT PLASMA MEMBRANE Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations response to drug|drug transport drug transmembrane transporter activity integral to membrane|integral to plasma membrane
YGL243W YGL243W TAD1 hom Verified 0.722071562201237 0.23512524056102 no 1145 0.216554171502145 735 NA FT RNA PROCESSING NUCLEUS tRNA-specific adenosine deaminase, deaminates adenosine-37 to inosine in tRNA-Ala tRNA modification tRNA-specific adenosine-37 deaminase activity nucleus
YML005W YML005W TRM12 hom Verified 0.721729462975758 0.235230412036445 no 1146 0.260783288616389 874 NA FT RNA PROCESSING S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; required for wybutosine formation in phenylalanine-accepting tRNA wybutosine biosynthetic process|tRNA methylation S-adenosylmethionine-dependent methyltransferase activity|transferase activity, transferring alkyl or aryl (other than methyl) groups cytoplasm
YLL030C_d YLL030C RRT7 hom Dubious 0.721390042245778 0.235334785728872 no 1147 0.219497499245313 763 NA Identified in a screen for mutants with increased levels of rDNA transcription; dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YBR092C YBR092C PHO3 hom Verified 0.720828903360956 0.235507394995562 no 1148 0.219176661417248 751 NA Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin phosphate-containing compound metabolic process|thiamine-containing compound metabolic process acid phosphatase activity cell wall-bounded periplasmic space
YKL040C YKL040C NFU1 hom Verified 0.720749709129929 0.235531761180558 no 1149 0.21340659950039 701 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS|COFACTOR METABOLISM MITOCHONDRION Protein involved in iron metabolism in mitochondria; similar to NifU, which is a protein required for the maturation of the Fe/S clusters of nitrogenase in nitrogen-fixing bacteria cellular iron ion homeostasis|iron-sulfur cluster assembly|intracellular sequestering of iron ion molecular_function mitochondrion|mitochondrial matrix
YDL068W_d YDL068W YDL068W hom Dubious 0.720405353803314 0.235637727311693 no 1150 0.259376398834079 908 NA Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR454W_p YLR454W FMP27 hom Uncharacterized 0.720293695882477 0.235672092691849 no 1151 0.226449210388857 807 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YDR218C YDR218C SPR28 hom Verified 0.719636181848634 0.235874514323934 no 1152 0.216281265459129 725 NA FT CELL CYCLE|CELL DIVISION SITE OF POLARIZED GROWTH|CYTOSKELETON Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; meiotic septin expressed at high levels during meiotic divisions and ascospore formation sexual sporulation resulting in formation of a cellular spore structural molecule activity spindle microtubule|meiotic spindle|septin complex|prospore membrane|ascospore wall
YCR106W YCR106W RDS1 hom Verified 0.719543890484327 0.235902934722098 no 1153 0.218617836850556 789 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Putative zinc cluster transcription factor; involved in conferring resistance to cycloheximide response to xenobiotic stimulus sequence-specific DNA binding|DNA binding nucleus
YOL053W YOL053W AIM39 hom Verified 0.719146248325705 0.236025407073429 no 1154 0.203112036005179 661 NA FT MITOCHONDRION Putative protein of unknown function; null mutant displays elevated frequency of mitochondrial genome loss biological_process molecular_function cellular_component
YDR075W YDR075W PPH3 hom Verified 0.718340834989586 0.236273578792223 no 1155 0.21109947392233 718 NA FT CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Catalytic subunit of protein phosphatase PP4 complex; active complex is composed of Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; involved in activation of Gln3p to alleviate nitrogen catabolite repression; Pph3p and Psy2p localize to foci on meiotic chromosomes Unknown|signal transduction involved in meiotic recombination checkpoint|double-strand break repair via homologous recombination|protein dephosphorylation|positive regulation of nitrogen compound metabolic process protein serine/threonine phosphatase activity condensed nuclear chromosome|nucleus|cytoplasm
YPR114W_p YPR114W YPR114W hom Uncharacterized 0.71829196818069 0.236288640726494 no 1156 0.243557758145746 833 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Putative protein of unknown function biological_process molecular_function integral to membrane|endoplasmic reticulum
YMR118C_p YMR118C SHH3 hom Uncharacterized 0.717110884961461 0.23665283995484 no 1157 0.215962389089668 725 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Putative mitochondrial inner membrane protein of unknown function; although similar to Sdh3p, Shh3p is not a stoichiometric subunit of either succinate dehydrogenase or of the TIM22 translocase biological_process molecular_function integral to membrane
YMR099C YMR099C YMR099C hom Verified 0.715734269598466 0.23707772298324 no 1158 0.255279624516529 869 NA FT CARBOHYDRATE METABOLISM NUCLEUS Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS cellular carbohydrate metabolic process glucose-6-phosphate 1-epimerase activity nucleus|cytoplasm
YOL070C YOL070C NBA1 hom Verified 0.715654486678512 0.237102360286599 no 1159 0.24528174658272 845 NA FT SITE OF POLARIZED GROWTH Protein of unknown function, localizes to the bud neck and cytoplasm; interacts with Nap1p; may interact with ribosomes, based on co-purification experiments; potential Cdc28p substrate biological_process molecular_function ribosome|cellular bud neck|cytoplasm
YPR119W YPR119W CLB2 hom Verified 0.715522623946366 0.237143083140254 no 1160 0.253406878537975 921 NA FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome G2/M transition of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|positive regulation of spindle pole body separation cyclin-dependent protein kinase regulator activity nucleus|spindle pole body|cellular bud neck|spindle|cytoplasm
YML009W-B_d YML009W-B YML009W-B hom Dubious 0.714423252095486 0.237482749058839 no 1161 0.241890526832794 852 NA Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition Unknown Unknown Unknown
YCR053W YCR053W THR4 hom Verified 0.713644453413756 0.237723531035714 no 1162 0.212047553449081 691 NA FT VESICLE-MEDIATED TRANSPORT|KETONE METABOLISM|MEMBRANE ORGANIZATION|AMINO ACID METABOLISM NUCLEUS Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway endocytosis|threonine metabolic process threonine synthase activity nucleus|cytoplasm
YDL012C YDL012C YDL012C hom Verified 0.71320072134864 0.237860779994213 no 1163 0.19961394606718 684 NA FT PLASMA MEMBRANE Tail-anchored plasma membrane protein with a conserved CYSTM module; possibly involved in response to stress; may contribute to non-homologous end-joining (NHEJ) based on ydl012c htz1 double null phenotype; YDL012C has a paralog, YBR016W, that arose from the whole genome duplication biological_process molecular_function plasma membrane
YGR014W YGR014W MSB2 hom Verified 0.712416445677504 0.238103467345742 no 1164 0.269002166921545 929 NA FT SIGNALING SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Mucin family member involved in signaling; functions in the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; is processed into secreted and cell-associated forms by the aspartyl protease, Yps1p; also functions as an osmosensor in parallel to the Sho1p-mediated pathway; potential Cdc28p substrate signal transduction involved in filamentous growth|osmosensory signaling pathway via Sho1 osmosensor|establishment of cell polarity|hyperosmotic response|response to osmotic stress osmosensor activity site of polarized growth|integral to plasma membrane
YMR311C YMR311C GLC8 hom Verified 0.71179963668511 0.238294428863316 no 1165 0.250764729013088 871 NA FT SIGNALING|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|CHROMOSOME SEGREGATION NUCLEUS Regulatory subunit of protein phosphatase 1 (Glc7p); involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2; protein abundance increases in response to DNA replication stress chromosome segregation|glycogen biosynthetic process enzyme activator activity nucleus|cytoplasm
YFR030W YFR030W MET10 hom Verified 0.71140429039954 0.238416870543868 no 1166 0.23832185622349 821 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY Subunit alpha of assimilatory sulfite reductase, which converts sulfite into sulfide sulfate assimilation sulfite reductase (NADPH) activity sulfite reductase complex (NADPH)
YKR088C YKR088C TVP38 hom Verified 0.710259878403609 0.23877149755246 no 1167 0.238084594148244 842 NA FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|CYTOSKELETON ORGANIZATION ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; required for asymmetric localization of Kar9p during mitosis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern vesicle-mediated transport|mitotic spindle elongation molecular_function integral to membrane|integral to Golgi membrane|cytoplasm
YBR298C YBR298C MAL31 hom Verified 0.710109143148515 0.238818228445499 no 1168 0.259426836459741 899 NA FT CARBOHYDRATE METABOLISM Maltose permease, high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL3 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; functional in genomic reference strain S288C alpha-glucoside transport|transmembrane transport alpha-glucoside:hydrogen symporter activity integral to membrane|membrane
YLR098C YLR098C CHA4 hom Verified 0.709766976187839 0.238924325496122 no 1169 0.247216992931526 814 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS DNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain positive regulation of transcription, DNA-dependent|cellular amino acid catabolic process sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nucleus
YDL192W YDL192W ARF1 hom Verified 0.708228709071035 0.239401620263193 no 1170 0.267670946289152 911 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|RESPONSE TO NUTRIENT LEVELS GOLGI APPARATUS ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication ER to Golgi vesicle-mediated transport|Golgi to plasma membrane transport|intra-Golgi vesicle-mediated transport|macroautophagy GTPase activity cytosol|Golgi-associated vesicle
YGR100W YGR100W MDR1 hom Verified 0.707726915710697 0.239557429679852 no 1171 0.248187612105135 863 NA FT PROTEIN LOCALIZATION|SIGNALING|NUCLEOTIDE METABOLISM Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function intracellular protein transport Rab GTPase activator activity cytoplasm
YBR206W_d YBR206W YBR206W hom Dubious 0.707179323879721 0.239727522906305 no 1172 0.249622598403642 857 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KTR3 Unknown Unknown Unknown
YGL261C_p YGL261C PAU11 hom Uncharacterized 0.7070854894837 0.239756676402114 no 1173 0.239207609043451 799 NA Putative protein of unknown function and member of the seripauperin multigene family encoded mainly in subtelomeric regions; mRNA expression appears to be regulated by SUT1 and UPC2 biological_process molecular_function cellular_component
YER135C_d YER135C YER135C hom Dubious 0.706758445077441 0.239858301252057 no 1174 0.250030208501588 817 NA Dubious open reading frame unlikely to encode a protein; YER135C is not an essential gene Unknown Unknown Unknown
YLR017W YLR017W MEU1 hom Verified 0.705502347662352 0.240248835734737 no 1175 0.221926832434936 758 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Methylthioadenosine phosphorylase (MTAP), catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity; regulates ADH2 gene expression L-methionine salvage from methylthioadenosine|glutamate biosynthetic process S-methyl-5-thioadenosine phosphorylase activity|mRNA binding cytoplasm
YMR034C_p YMR034C YMR034C hom Uncharacterized 0.70476350138787 0.240478712903118 no 1176 0.249292887821239 827 NA Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene biological_process sterol transporter activity integral to membrane
YMR048W YMR048W CSM3 hom Verified 0.704602511560126 0.240528817541071 no 1177 0.214566108681913 728 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Replication fork associated factor; required for stable replication fork pausing; component of the DNA replication checkpoint pathway; required for accurate chromosome segregation during meiosis; forms nuclear foci upon DNA replication stress DNA repair|DNA replication checkpoint|meiotic chromosome segregation|maintenance of DNA repeat elements|replication fork arrest|replication fork protection|mitotic sister chromatid cohesion|establishment of mitotic sister chromatid cohesion molecular_function replication fork protection complex|nucleus
YFL046W_p YFL046W FMP32 hom Uncharacterized 0.70409950580184 0.240685403936901 no 1178 0.235616703519971 763 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YBL059W_p YBL059W YBL059W hom Uncharacterized 0.704097808728238 0.240685932332183 no 1179 0.257895060587372 890 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YBL059W has a paralog, YER093C-A, that arose from the whole genome duplication biological_process molecular_function mitochondrion
YGR243W YGR243W FMP43 hom Verified 0.70298373033457 0.241032944353471 no 1180 0.240176238814703 867 NA FT MITOCHONDRION Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; more highly expressed in glucose-containing minimal medium than in lactate-containing medium; expression regulated by osmotic and alkaline stresses; protein abundance increases in response to DNA replication stress mitochondrial pyruvate transport pyruvate transmembrane transporter activity mitochondrion|mitochondrial membrane
YOL059W YOL059W GPD2 hom Verified 0.702963771485852 0.241039163595315 no 1181 0.276304509800937 945 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM MITOCHONDRION NAD-dependent glycerol 3-phosphate dehydrogenase, homolog of Gpd1p, expression is controlled by an oxygen-independent signaling pathway required to regulate metabolism under anoxic conditions; located in cytosol and mitochondria; constitutively active but is inactivated via phosphorylation by energy-stress responsive kinase SNF1 NADH oxidation|glycerol metabolic process glycerol-3-phosphate dehydrogenase [NAD+] activity cytosol|mitochondrion
YPL018W YPL018W CTF19 hom Verified 0.702954175608008 0.241042153732963 no 1182 0.274193139470078 934 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME KINETOCHORE Outer kinetochore protein, needed for accurate chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-P and fission yeast fta2 attachment of spindle microtubules to kinetochore|chromosome segregation|establishment of mitotic sister chromatid cohesion molecular_function COMA complex|condensed nuclear chromosome kinetochore|nucleus
YBR250W YBR250W SPO23 hom Verified 0.702905097709915 0.241057447039057 no 1183 0.246133036859269 847 NA FT CELL CYCLE Protein of unknown function; associates with meiosis-specific protein Spo1p meiosis molecular_function cellular_component
YJR113C YJR113C RSM7 hom Verified 0.70171706969184 0.24142781281159 no 1184 0.260078966433556 875 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S7 ribosomal protein mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YNL239W YNL239W LAP3 hom Verified 0.701304969290993 0.241556356600884 no 1185 0.230621637560427 778 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|PROTEOLYSIS MITOCHONDRION Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH response to antibiotic|negative regulation of transcription from RNA polymerase II promoter|homocysteine catabolic process double-stranded DNA binding|cysteine-type peptidase activity|mRNA binding|single-stranded DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding mitochondrion|cytoplasm
YJL136C YJL136C RPS21B hom Verified 0.701240434216508 0.241576489970775 no 1186 0.250657415981956 846 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|cytoplasmic translation|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit
YJL055W_p YJL055W YJL055W hom Uncharacterized 0.700848980395724 0.24169863354328 no 1187 0.24448697676762 845 NA FT NUCLEUS Putative protein of unknown function, proposed to be involved in the metabolism of purine and pyrimidine base analogues; deletion mutants are sensitive to HAP and AHA; overexpression confers resistance to 5-FOA and 5-FU response to chemical stimulus|response to purine-containing compound molecular_function nucleus|cytoplasm
YDR491C_d YDR491C YDR491C hom Dubious 0.7002710361789 0.241879028139083 no 1188 0.211698938584913 705 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDL156W YDL156W CMR1 hom Verified 0.700061351742229 0.241944495311616 no 1189 0.255384258841381 876 NA FT NUCLEUS|CHROMOSOME DNA-binding protein with preference for UV-damaged DNA; protein sequence contains three WD domains (WD-40 repeat); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; potential regulatory target of Mbp1p, which binds to the promoter region; co-localizes with Hos2p in nuclear foci in response to DNA damage by MMS biological_process DNA binding nuclear chromatin|nucleus|cytoplasm
YDR119W_p YDR119W VBA4 hom Uncharacterized 0.699175630530707 0.242221139088611 no 1190 0.207662362573743 699 NA Protein of unknown function with proposed role as a basic amino acid permease based on phylogeny; GFP-fusion protein localizes to vacuolar membrane; physical interaction with Atg27p suggests a possible role in autophagy; non-essential gene biological_process molecular_function fungal-type vacuole membrane|integral to membrane
YMR106C YMR106C YKU80 hom Verified 0.697149614507655 0.242854583627555 no 1191 0.22846046924527 817 NA FT PROTEIN LOCALIZATION|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING NUCLEUS|CHROMOSOME Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair chromatin assembly or disassembly|protein localization to chromosome|chromatin silencing|double-strand break repair via nonhomologous end joining|donor selection|telomere maintenance|double-strand break repair via homologous recombination damaged DNA binding|RNA binding|DNA binding|telomeric DNA binding nuclear chromatin|nuclear telomeric heterochromatin|Ku70:Ku80 complex
YOL122C YOL122C SMF1 hom Verified 0.697097855210586 0.242870778177871 no 1192 0.229620959471657 793 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Divalent metal ion transporter with a broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins copper ion transport|cellular copper ion homeostasis|manganese ion transport|cadmium ion transport|cellular manganese ion homeostasis|cellular cadmium ion homeostasis|iron ion transport solute:hydrogen symporter activity|inorganic cation transmembrane transporter activity integral to membrane|plasma membrane
YDL242W_d YDL242W YDL242W hom Dubious 0.696393905450535 0.243091089365326 no 1193 0.220003940193248 728 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOR252W YOR252W TMA16 hom Verified 0.695545833487925 0.243356649129415 no 1194 0.232000598093575 789 NA FT NUCLEUS Protein of unknown function that associates with ribosomes biological_process molecular_function ribosome|nucleus
YLR070C YLR070C XYL2 hom Verified 0.695472385681882 0.243379655474199 no 1195 0.249262178180342 823 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM Xylitol dehydrogenase, converts xylitol to D-xylulose; expression induced by xylose, even though this pentose sugar is not well utilized by S. cerevisiae; null mutant has cell wall defect xylulose biosynthetic process D-xylulose reductase activity cellular_component
YEL056W YEL056W HAT2 hom Verified 0.694415274817321 0.24371090861057 no 1196 0.221057057266967 739 NA FT CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING NUCLEUS HISTONE ACETYLTRANSFERASE Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing histone acetylation|chromatin assembly or disassembly|chromatin silencing at telomere histone acetyltransferase activity|histone binding histone acetyltransferase complex|nucleus|cytoplasm
YJR039W_p YJR039W YJR039W hom Uncharacterized 0.69355413940844 0.243980931255422 no 1197 0.205976845353959 726 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YKR103W YKR103W NFT1 hom Verified 0.693511082837448 0.243994436560552 no 1198 0.24586895902042 849 NA FT NUCLEOTIDE METABOLISM Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds. transport ATPase activity, coupled to transmembrane movement of substances integral to membrane|membrane
YLR224W_p YLR224W YLR224W hom Uncharacterized 0.69276908845007 0.244227236986301 no 1199 0.223074060041796 759 NA FT PROTEOLYSIS F-box protein and component of SCF ubiquitin ligase complexes involved in ubiquitin-dependent protein catabolism; readily monoubiquitinated in vitro by SCF-Ubc4 complexes; YLR224W is not an essential gene SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular response to methylmercury ubiquitin-protein ligase activity|protein binding, bridging SCF ubiquitin ligase complex
YOL131W_p YOL131W YOL131W hom Uncharacterized 0.692045965115498 0.244454231797423 no 1200 0.243751872056525 861 NA Putative protein of unknown function biological_process molecular_function cellular_component
YMR148W YMR148W OSW5 hom Verified 0.691961238431657 0.244480835690616 no 1201 0.196652605034146 648 NA Protein of unknown function that may play a role in spore wall assembly; predicted to contain an N-terminal transmembrane domain; osw5 null mutant spores exhibit increased spore wall permeability and sensitivity to beta-glucanase digestion biological_process molecular_function integral to membrane
YPL208W YPL208W RKM1 hom Verified 0.691642815693451 0.24458083330281 no 1202 0.242835945111863 822 NA FT NUCLEUS SET-domain lysine-N-methyltransferase, catalyzes the formation of dimethyllysine residues on the large ribsomal subunit proteins L23a (Rpl23Ap and Rpl23Bp) and L18 (Rps18Ap and Rps18Bp) peptidyl-lysine dimethylation protein-lysine N-methyltransferase activity nucleus|cytoplasm
YML080W YML080W DUS1 hom Verified 0.691162321843124 0.24473176948841 no 1203 0.199047034439095 661 NA FT RNA PROCESSING|OXIDATION-REDUCTION PROCESS NUCLEUS Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNA(Phe) at U17 tRNA modification tRNA dihydrouridine synthase activity nucleus
YMR088C YMR088C VBA1 hom Verified 0.690948896494264 0.244798828275625 no 1204 0.242513841611479 822 NA Permease of basic amino acids in the vacuolar membrane basic amino acid transport basic amino acid transmembrane transporter activity fungal-type vacuole membrane|integral to membrane
YPL200W YPL200W CSM4 hom Verified 0.690738246913422 0.244865024607001 no 1205 0.249272253943219 852 NA FT CELL CYCLE|CHROMOSOME SEGREGATION ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|CHROMOSOME Protein required for accurate chromosome segregation during meiosis; involved in meiotic telomere clustering (bouquet formation) and telomere-led rapid prophase movements meiotic telomere clustering|meiotic chromosome segregation|synapsis|regulation of reciprocal meiotic recombination molecular_function nuclear chromosome, telomeric region|endoplasmic reticulum membrane
YPL130W YPL130W SPO19 hom Verified 0.690463550292978 0.244951362100135 no 1206 0.216257182832031 727 NA FT CELL CYCLE|MEMBRANE ORGANIZATION Meiosis-specific prospore protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation; identified as a weak high-copy suppressor of the spo1-1 ts mutation meiosis|spore membrane bending pathway molecular_function fungal-type cell wall|prospore membrane
YLR207W YLR207W HRD3 hom Verified 0.690282826644589 0.245008172701749 no 1207 0.22381184124706 743 NA FT PROTEOLYSIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM UBIQUITIN LIGASE COMPLEX Resident protein of the ER membrane that plays a central role in ER-associated protein degradation (ERAD), forms HRD complex with Hrd1p and ERAD determinants that engages in lumen to cytosol communication and coordination of ERAD events ER-associated protein catabolic process ubiquitin-protein ligase activity Hrd1p ubiquitin ligase ERAD-M complex|luminal surveillance complex|Hrd1p ubiquitin ligase ERAD-L complex|endoplasmic reticulum membrane
YNR069C YNR069C BSC5 hom Verified 0.689363490239151 0.245297276435701 no 1208 0.253398699807215 857 NA Protein of unknown function; shows homology with N-terminal end of Bul1p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough expression includes YNR068C and the locus for this readthrough is termed BUL3; Bul3p is involved in ubiquitin-mediated sorting of plasma membrane proteins; readthrough and shortened forms of Bul3p interact with Rsp5p differently in vitro biological_process molecular_function cellular_component
YLR279W_d YLR279W YLR279W hom Dubious 0.689360803702717 0.245298121539496 no 1209 0.262058473560368 926 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPL223C YPL223C GRE1 hom Verified 0.688893432590563 0.245445166292746 no 1210 0.262439836098376 868 NA Hydrophilin essential in dessication-rehydration process; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway biological_process molecular_function cytoplasm
YPL265W YPL265W DIP5 hom Verified 0.687594748543776 0.245854008068466 no 1211 0.220855470458402 782 NA FT PLASMA MEMBRANE Dicarboxylic amino acid permease; mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly; relocalizes from plasma membrane to vacuole upon DNA replication stress amino acid transport amino acid transmembrane transporter activity integral to membrane|plasma membrane
YER058W YER058W PET117 hom Verified 0.687341531352931 0.245933766529137 no 1212 0.238321766135033 830 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Protein required for assembly of cytochrome c oxidase mitochondrial respiratory chain complex IV assembly molecular_function mitochondrion
YOR230W YOR230W WTM1 hom Verified 0.687194001711738 0.245980241880214 no 1213 0.234493026767628 792 NA FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CELL CYCLE|GENE SILENCING NUCLEUS Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; required for nuclear localization of the ribonucleotide reductase small subunit Rnr2p and Rnr4p; contains WD repeats negative regulation of chromatin silencing at silent mating-type cassette|maintenance of protein location in nucleus|negative regulation of transcription from RNA polymerase II promoter during meiosis|negative regulation of chromatin silencing at telomere|protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter protein binding|transcription corepressor activity nucleus
YGL220W YGL220W FRA2 hom Verified 0.686587705207746 0.246171289188235 no 1214 0.244748334093959 834 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; null mutant fails to repress iron regulon and is sensitive to nickel negative regulation of transcription from RNA polymerase II promoter in response to iron molecular_function cytosol|nucleus|cytoplasm
YIL095W YIL095W PRK1 hom Verified 0.685638197337771 0.246470644072875 no 1215 0.236493294618896 817 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION SITE OF POLARIZED GROWTH|CYTOSKELETON Protein serine/threonine kinase; regulates the organization and function of the actin cytoskeleton and reduces endocytic ability of cell through the phosphorylation of the Pan1p-Sla1p-End3p protein complex; PRK1 has a paralog, ARK1, that arose from the whole genome duplication regulation of endocytosis|actin filament organization|protein phosphorylation|actin cortical patch assembly|cytokinesis protein serine/threonine kinase activity|protein kinase activity mating projection tip|actin cortical patch
YPL189W YPL189W GUP2 hom Verified 0.685569668446359 0.246492256976342 no 1216 0.192978169970612 616 NA Probable membrane protein with a possible role in proton symport of glycerol; member of the MBOAT family of putative membrane-bound O-acyltransferases; Gup1p homolog glycerol transport O-acyltransferase activity integral to membrane|membrane
YOL047C_p YOL047C YOL047C hom Uncharacterized 0.683532143469842 0.247135323068993 no 1217 0.236491124787903 784 NA Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern biological_process molecular_function integral to membrane|cytoplasm
YLR390W YLR390W ECM19 hom Verified 0.683492971194959 0.247147695070566 no 1218 0.273907200348217 975 NA FT CELL WALL ORG/BIOGENESIS MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies fungal-type cell wall organization molecular_function mitochondrion
YKL220C YKL220C FRE2 hom Verified 0.683094077622018 0.247273698747663 no 1219 0.21856169610948 712 NA FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY PLASMA MEMBRANE Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels iron ion transport|copper ion import ferric-chelate reductase activity integral to membrane|plasma membrane
YOR081C YOR081C TGL5 hom Verified 0.682218209970796 0.247550490863708 no 1220 0.22882725734779 764 NA FT LIPID METABOLISM Bifunctional enzyme with triacylglycerol lipase and lysophosphatidic acid acyltransferase activity; involved in triacylglycerol mobilization; localizes to lipid particles; potential Cdc28p substrate triglyceride mobilization lysophosphatidic acid acyltransferase activity|triglyceride lipase activity lipid particle
YIL056W YIL056W VHR1 hom Verified 0.681667904271618 0.247724483370516 no 1221 0.214019985459176 728 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS NUCLEUS Transcriptional activator; required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations; VHR1 has a paralog, VHR2, that arose from the whole genome duplication regulation of transcription from RNA polymerase II promoter in response to biotin starvation|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity nucleus|cytoplasm
YDR247W YDR247W VHS1 hom Verified 0.681275644254364 0.247848545750441 no 1222 0.226535825997345 761 NA FT CELL CYCLE|PROTEIN PHOSPHORYLATION Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p protein phosphorylation|G1/S transition of mitotic cell cycle protein serine/threonine kinase activity|protein kinase activity cytoplasm
YJR063W YJR063W RPA12 hom Verified 0.679595234787598 0.24838039388267 no 1223 0.279950813389549 985 NA FF|FT NUCLEUS RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex termination of RNA polymerase I transcription|transcription of nuclear large rRNA transcript from RNA polymerase I promoter molecular_function DNA-directed RNA polymerase I complex
YNL136W YNL136W EAF7 hom Verified 0.679318817186598 0.248467938038953 no 1224 0.271085640229207 944 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS HISTONE ACETYLTRANSFERASE Subunit of the NuA4 histone acetyltransferase complex, which acetylates the N-terminal tails of histones H4 and H2A DNA repair|histone acetylation|regulation of transcription from RNA polymerase II promoter molecular_function histone acetyltransferase complex|nucleus|NuA4 histone acetyltransferase complex
YPR134W YPR134W MSS18 hom Verified 0.67930307866416 0.248472923077572 no 1225 0.254565488101184 900 NA FT RNA PROCESSING MITOCHONDRION Nuclear encoded protein needed for efficient splicing of mitochondrial COX1 aI5beta intron; mss18 mutations block cleavage of 5' exon - intron junction; phenotype of intronless strain suggests additional functions Group I intron splicing molecular_function mitochondrion
YFL011W YFL011W HXT10 hom Verified 0.678433194825995 0.248748533997197 no 1226 0.274099903153378 959 NA FT MITOCHONDRION|PLASMA MEMBRANE Putative hexose transporter, expressed at low levels and expression is repressed by glucose hexose transport|transmembrane transport galactose transmembrane transporter activity|mannose transmembrane transporter activity|fructose transmembrane transporter activity|glucose transmembrane transporter activity mitochondrion|integral to membrane|plasma membrane
YLR299W YLR299W ECM38 hom Verified 0.678262234801882 0.248802719500563 no 1227 0.227193175754523 753 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Gamma-glutamyltranspeptidase, major glutathione-degrading enzyme; involved in detoxification of electrophilic xenobiotics; expression induced mainly by nitrogen starvation xenobiotic metabolic process|glutathione catabolic process gamma-glutamyltransferase activity fungal-type vacuole
YER103W YER103W SSA4 hom Verified 0.677996940397552 0.248886816573808 no 1228 0.234136299708798 821 NA FT PROTEIN LOCALIZATION NUCLEUS Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation; SSA4 has a paralog, SSA3, that arose from the whole genome duplication protein folding|SRP-dependent cotranslational protein targeting to membrane, translocation|response to stress unfolded protein binding|ATPase activity nucleus|cytoplasm
YBL002W YBL002W HTB2 hom Verified 0.677849349112941 0.248933608863271 no 1229 0.225573868240555 781 NA FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB1; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation chromatin assembly or disassembly DNA binding replication fork protection complex|nuclear nucleosome
YOR264W YOR264W DSE3 hom Verified 0.677632607684282 0.249002332975682 no 1230 0.236677086866007 823 NA FT CELL CYCLE SITE OF POLARIZED GROWTH Daughter cell-specific protein, may help establish daughter fate; relocalizes from bud neck to cytoplasm upon DNA replication stress biological_process molecular_function cellular bud neck
YKR043C YKR043C SHB17 hom Verified 0.677401021597087 0.249075775169629 no 1231 0.290906870372759 986 NA FT CARBOHYDRATE METABOLISM NUCLEUS Sedoheptulose bisphosphatase involved in riboneogenesis; dephosphorylates sedoheptulose 1,7-bisphosphate, which is converted via the nonoxidative pentose phosphate pathway to ribose-5-phosphate; facilitates the conversion of glycolytic intermediates to pentose phosphate units; also has fructose 1,6-bisphosphatase activity but this is probably not biologically relevant, since deletion does not affect FBP levels; GFP-fusion protein localizes to the cytoplasm and nucleus ribose phosphate biosynthetic process sedoheptulose-bisphosphatase activity nucleus|cytoplasm
YML090W_d YML090W YML090W hom Dubious 0.677025790239298 0.249194795611034 no 1232 0.243207362105006 842 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source Unknown Unknown Unknown
YKL118W_d YKL118W YKL118W hom Dubious 0.675009647523633 0.249834817780084 no 1233 0.344681934221423 1130 NA FF Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene VPH2 Unknown Unknown Unknown
YBR260C YBR260C RGD1 hom Verified 0.674490759476595 0.249999679274407 no 1234 0.227404408662145 756 NA FT SIGNALING SITE OF POLARIZED GROWTH|CYTOSKELETON GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization response to acid|osmosensory signaling pathway Rho GTPase activator activity|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding cellular bud|mating projection tip|actin cortical patch
YOL141W YOL141W PPM2 hom Verified 0.673590389189821 0.250285882520442 no 1235 0.208108167853441 684 NA FT RNA PROCESSING MITOCHONDRION AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p tRNA methylation|wybutosine biosynthetic process tRNA methyltransferase activity mitochondrion|cytoplasm
YPR197C_d YPR197C YPR197C hom Dubious 0.673471165953072 0.250323793368027 no 1236 0.306558508985649 1045 NA FF Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YER091C YER091C MET6 hom Verified 0.673374977488445 0.250354381790597 no 1237 0.173171880365169 587 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Cobalamin-independent methionine synthase, involved in methionine biosynthesis and regeneration; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs methionine biosynthetic process 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity plasma membrane|cytoplasm
YHR061C YHR061C GIC1 hom Verified 0.673227392733077 0.250401318347973 no 1238 0.244819288864198 806 NA FT CELL CYCLE|SIGNALING|CELL DIVISION SITE OF POLARIZED GROWTH|CYTOSKELETON Protein involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain; relocalizes from bud neck to nucleus upon DNA replication stress regulation of exit from mitosis|establishment of cell polarity|axial cellular bud site selection|Rho protein signal transduction Rho GTPase binding|Rho GTPase activator activity incipient cellular bud site|actin cap|mating projection tip|cellular bud neck|cellular bud tip
YIL112W YIL112W HOS4 hom Verified 0.67256133154167 0.250613204601495 no 1239 0.233059965987145 814 NA FT CELL CYCLE|CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Subunit of the Set3 complex, which is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; potential Cdc28p substrate negative regulation of meiosis|histone deacetylation molecular_function Set3 complex
YLR059C YLR059C REX2 hom Verified 0.672411956299121 0.250660736634823 no 1240 0.25964614525814 909 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION 3'-5' RNA exonuclease; involved in 3'-end processing of U4 and U5 snRNAs, 5S and 5.8S rRNAs, and RNase P and RNase MRP RNA; localized to mitochondria and null suppresses escape of mtDNA to nucleus in yme1 yme2 mutants; RNase D exonuclease U5 snRNA 3'-end processing|U4 snRNA 3'-end processing|mitochondrial genome maintenance|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 3'-5'-exoribonuclease activity|3'-5' exonuclease activity mitochondrion
YOR239W YOR239W ABP140 hom Verified 0.67241188276579 0.250660760034714 no 1241 0.244616213468732 823 NA FT RNA PROCESSING|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON AdoMet-dependent tRNA methyltransferase and actin binding protein; C-terminal domain is responsible for 3-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA-Thr and tRNA-Ser and contains an S-adenosylmethionine (AdoMet) binding motif; N-terminal actin binding sequence interacts with actin filaments and localizes to actin patches and cables; N- and C-terminal domains are encoded in separate ORFs that are translated into one protein via a +1 frameshift actin filament bundle assembly|tRNA methylation tRNA (cytosine-3-)-methyltransferase activity|actin filament binding|protein binding, bridging actin filament|actin filament bundle|mating projection tip|actin cortical patch
YBL011W YBL011W SCT1 hom Verified 0.672263887498785 0.250707857662956 no 1242 0.246981369822081 863 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase of the glycerolipid biosynthesis pathway, prefers 16-carbon fatty acids, similar to Gpt2p, gene is constitutively transcribed phospholipid biosynthetic process glycerol-3-phosphate O-acyltransferase activity|glycerone-phosphate O-acyltransferase activity integral to membrane|endoplasmic reticulum
YFL030W YFL030W AGX1 hom Verified 0.671783782728818 0.250860677210102 no 1243 0.241686919096887 800 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases glycine biosynthetic process, by transamination of glyoxylate alanine-glyoxylate transaminase activity mitochondrion
YDR149C_d YDR149C YDR149C hom Dubious 0.671498592626014 0.250951477865873 no 1244 0.248912383397718 853 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene NUM1; null mutation blocks anaerobic growth Unknown Unknown Unknown
YBR266C_d YBR266C SLM6 hom Dubious 0.67143536238131 0.250971611872509 no 1245 0.259284893154011 857 NA Protein with a potential role in actin cytoskeleton organization; gene exhibits synthetic genetic interaction with MSS4 encoding phosphatidylinositol 4-phosphate kinase Unknown Unknown Unknown
YFL051C_p YFL051C YFL051C hom Uncharacterized 0.669211152999177 0.251680396361779 no 1246 0.222786937155145 735 NA FT PLASMA MEMBRANE Putative protein of unknown function; YFL051C is not an essential gene biological_process molecular_function cellular_component
YHR094C YHR094C HXT1 hom Verified 0.669065235777383 0.251726932444846 no 1247 0.247195140531031 848 NA FT PLASMA MEMBRANE Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting; HXT1 has a paralog, HXT6, what arose from the whole genome duplication mannose transport|glucose transport galactose transmembrane transporter activity|pentose transmembrane transporter activity|mannose transmembrane transporter activity|glucose transmembrane transporter activity|fructose transmembrane transporter activity integral to membrane|plasma membrane
YGL014W YGL014W PUF4 hom Verified 0.667924721773671 0.252090822941393 no 1248 0.277939910960114 968 NA FT PROTEIN LOCALIZATION|CHROMATIN ORGANIZATION|TRANSLATION|GENE SILENCING Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|negative regulation of translation|protein localization|negative regulation of chromatin silencing involved in replicative cell aging mRNA binding cytoplasm
YGR052W_p YGR052W FMP48 hom Uncharacterized 0.666613924153101 0.252509386333894 no 1249 0.290702650649599 981 NA FT PROTEIN PHOSPHORYLATION MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation protein phosphorylation protein kinase activity mitochondrion
YKR069W YKR069W MET1 hom Verified 0.665954044055589 0.25272023748321 no 1250 0.253546432449589 882 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis siroheme biosynthetic process|methionine biosynthetic process|sulfate assimilation uroporphyrin-III C-methyltransferase activity intracellular
YLR094C YLR094C GIS3 hom Verified 0.665607685496438 0.252830946348526 no 1251 0.27197804915497 916 NA FT SIGNALING NUCLEUS Protein of unknown function intracellular signal transduction molecular_function nucleus|cytoplasm
YJL208C YJL208C NUC1 hom Verified 0.665372343505786 0.252906184822448 no 1252 0.254178431595425 858 NA FT NUCLEUS|MITOCHONDRION Major mitochondrial nuclease, has RNAse and DNA endo- and exonucleolytic activities; has roles in mitochondrial recombination, apoptosis and maintenance of polyploidy DNA catabolic process|RNA catabolic process|apoptotic process|DNA recombination ribonuclease activity|endodeoxyribonuclease activity|exodeoxyribonuclease activity mitochondrion|mitochondrial inner membrane|nucleus
YER183C YER183C FAU1 hom Verified 0.66505852523246 0.253006530374353 no 1253 0.259475361596902 899 NA FT COFACTOR METABOLISM MITOCHONDRION 5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis folic acid-containing compound biosynthetic process 5-formyltetrahydrofolate cyclo-ligase activity mitochondrion
YHL035C YHL035C VMR1 hom Verified 0.664980767590581 0.253031397153345 no 1254 0.260901894734549 884 NA FT NUCLEOTIDE METABOLISM MITOCHONDRION Vacuolar membrane protein involved in multiple drug resistance and metal sensitivity; ATP-binding cassette (ABC) family member involved in drug transport; potential Cdc28p substrate; induced under respiratory conditions transport|response to drug|response to metal ion|drug transport ATPase activity, coupled to transmembrane movement of substances fungal-type vacuole membrane|mitochondrion|integral to membrane|ribosome
YNL053W YNL053W MSG5 hom Verified 0.664510113533166 0.253181939068301 no 1255 0.263190373089566 913 NA FT PROTEIN LOCALIZATION|CELL CYCLE|SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION NUCLEUS Dual-specificity protein phosphatase; exists in 2 isoforms; required for maintenance of a low level of signaling through the cell integrity pathway, adaptive response to pheromone; regulates and is regulated by Slt2p; dephosphorylates Fus3p adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|regulation of fungal-type cell wall organization|inactivation of MAPK activity involved in cell wall biogenesis|regulation of MAPK export from nucleus|protein dephosphorylation|inactivation of MAPK activity involved in conjugation with cellular fusion protein tyrosine/serine/threonine phosphatase activity nucleus|cytoplasm
YDR014W YDR014W RAD61 hom Verified 0.664136848750316 0.253301363841617 no 1256 0.273701526563253 945 NA FT CELL CYCLE|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Subunit of a complex (Scc3p, Pds5p, Rad61p) that inhibits sister chromatid cohesion; inhibited by Eco1p-acetylated cohesin subunits Smc3p and Mcd1p; related to the human Wapl protein that controls the association of cohesin with chromatin mitotic sister chromatid cohesion molecular_function nuclear cohesin complex
YNL016W YNL016W PUB1 hom Verified 0.663694776188486 0.253442841723751 no 1257 0.237422463996996 804 NA FT PROTEIN COMPLEX ORG/BIOGENESIS NUCLEUS Poly (A)+ RNA-binding protein; abundant mRNP-component protein that binds mRNA and is required for stability of many mRNAs; component of glucose deprivation induced stress granules, involved in P-body-dependent granule assembly; protein abundance increases in response to DNA replication stress nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|stress granule assembly|regulation of mRNA stability mRNA binding|poly(U) RNA binding nucleus|cytoplasmic stress granule|cytoplasm
YHR135C YHR135C YCK1 hom Verified 0.663419043655363 0.253531106303486 no 1258 0.248599536572068 862 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL DIVISION|PROTEIN PHOSPHORYLATION ENDOPLASMIC RETICULUM|MITOCHONDRION|PLASMA MEMBRANE Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; YCK1 has a paralog, YCK2, that arose from the whole genome duplication cell morphogenesis|endocytosis|protein phosphorylation|cytokinesis|response to glucose stimulus protein serine/threonine kinase activity|protein kinase activity mitochondrion|endoplasmic reticulum|plasma membrane
YNL198C_d YNL198C YNL198C hom Dubious 0.663343974369696 0.253555139485261 no 1259 0.243610083758287 823 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YMR196W_p YMR196W YMR196W hom Uncharacterized 0.663265141696588 0.253580378791294 no 1260 0.271577103956843 923 NA FT CARBOHYDRATE METABOLISM Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene biological_process molecular_function cytoplasm
YLL009C YLL009C COX17 hom Verified 0.662900131025456 0.253697258907479 no 1261 0.24229151758457 802 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS MITOCHONDRION Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs mitochondrial respiratory chain complex IV assembly|intracellular copper ion transport copper chaperone activity cytosol|mitochondrion|mitochondrial intermembrane space
YPL115C YPL115C BEM3 hom Verified 0.662838877387279 0.253716875714961 no 1262 0.278670720542348 959 NA FT SIGNALING SITE OF POLARIZED GROWTH Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly negative regulation of Rho protein signal transduction|establishment of cell polarity Rho GTPase activator activity|phosphatidylinositol-3-phosphate binding cell cortex|incipient cellular bud site|mating projection tip|cytoplasm|cellular bud tip
YJL210W YJL210W PEX2 hom Verified 0.662782948536886 0.253734787926118 no 1263 0.244213753069489 828 NA FT PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION RING-finger peroxin and E3 ubiquitin ligase, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import protein import into peroxisome matrix ubiquitin-protein ligase activity|protein binding peroxisomal membrane
YLR405W YLR405W DUS4 hom Verified 0.66268873365036 0.253764963424077 no 1264 0.242437647349904 807 NA FT RNA PROCESSING|OXIDATION-REDUCTION PROCESS Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p tRNA modification tRNA dihydrouridine synthase activity cellular_component
YIL158W YIL158W AIM20 hom Verified 0.662439675893338 0.253844741651514 no 1265 0.257743037302041 886 NA FT CELL CYCLE Putative protein of unknown function; overexpression causes a cell cycle delay or arrest; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; null mutant displays elevated frequency of mitochondrial genome loss; relocalizes from nucleus to cytoplasm upon DNA replication stress biological_process molecular_function fungal-type vacuole
YFL048C YFL048C EMP47 hom Verified 0.661810193808439 0.254046436143508 no 1266 0.250732832362736 871 NA FT VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport ER to Golgi vesicle-mediated transport glycoprotein binding fungal-type vacuole membrane|integral to endoplasmic reticulum membrane|integral to Golgi membrane|ER to Golgi transport vesicle
YML068W YML068W ITT1 hom Verified 0.660777589970809 0.254377478232703 no 1267 0.228832039323236 800 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION Protein that modulates the efficiency of translation termination, interacts with translation release factors eRF1 (Sup45p) and eRF3 (Sup35p) in vitro, contains a zinc finger domain characteristic of the TRIAD class of proteins regulation of translational termination molecular_function cellular_component
YDR372C YDR372C VPS74 hom Verified 0.659729876001082 0.254713595410636 no 1268 0.292861419873969 996 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33 retrograde vesicle-mediated transport, Golgi to ER|endoplasmic reticulum unfolded protein response|protein localization to Golgi apparatus enzyme binding|phosphatidylinositol-4-phosphate binding cytosol|Golgi apparatus|nucleus|extrinsic to membrane|cytoplasm
YIL079C YIL079C AIR1 hom Verified 0.658846914305378 0.254997038872542 no 1269 0.25660344024852 863 NA FT RNA PROCESSING NUCLEUS Zinc knuckle protein; involved in nuclear RNA processing and degradation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; AIR1 has a paralog, AIR2, that arose from the whole genome duplication nuclear mRNA surveillance of mRNA 3'-end processing|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|ncRNA polyadenylation|nuclear polyadenylation-dependent snRNA catabolic process polynucleotide adenylyltransferase activity nucleolus|TRAMP complex
YPL092W YPL092W SSU1 hom Verified 0.658502702043703 0.255107580671371 no 1270 0.259518557342199 848 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein sulfite transport sulfite transmembrane transporter activity integral to membrane|plasma membrane
YDR057W YDR057W YOS9 hom Verified 0.658186927660484 0.255209011847242 no 1271 0.249864747070648 826 NA FT PROTEOLYSIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM UBIQUITIN LIGASE COMPLEX ER quality-control lectin; integral subunit of the HRD ligase; binds to glycans with terminal alpha-1,6 linked mannose on misfolded N-glycosylated proteins and participates in targeting proteins to ERAD; member of the OS-9 protein family ER-associated protein catabolic process oligosaccharide binding luminal surveillance complex|Hrd1p ubiquitin ligase ERAD-L complex|endoplasmic reticulum lumen
YMR292W YMR292W GOT1 hom Verified 0.657534437257052 0.25541866773347 no 1272 0.235673662000452 813 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Homodimeric protein that is packaged into COPII vesicles and cycles between the ER and Golgi; involved in secretory transport but not directly required for aspects of transport assayed in vitro; may influence membrane composition ER to Golgi vesicle-mediated transport|Golgi to endosome transport molecular_function integral to membrane|endoplasmic reticulum|Golgi apparatus|ER to Golgi transport vesicle|Golgi membrane
YPL065W YPL065W VPS28 hom Verified 0.657507589132806 0.255427296404366 no 1273 0.275086761880635 976 NA FF|FT PROTEIN LOCALIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p protein targeting to membrane|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein targeting to vacuole protein complex binding endosome|ESCRT I complex
YEL042W YEL042W GDA1 hom Verified 0.657026574479261 0.25558191465615 no 1274 0.251719646661415 851 NA FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate protein glycosylation guanosine-diphosphatase activity|uridine-diphosphatase activity Golgi apparatus
YML024W YML024W RPS17A hom Verified 0.656386278755861 0.255787808338228 no 1275 0.241266164808273 826 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17A has a paralog, RPS17B, that arose from the whole genome duplication cytoplasmic translation|ribosomal small subunit assembly structural constituent of ribosome cytosolic small ribosomal subunit
YBR001C YBR001C NTH2 hom Verified 0.656352291170283 0.255798739815773 no 1276 0.310481645610194 1085 NA FF|FT CARBOHYDRATE METABOLISM MITOCHONDRION Putative neutral trehalase, required for thermotolerance; may mediate resistance to other cellular stresses; NTH2 has a paralog, NTH1, that arose from the whole genome duplication trehalose catabolic process alpha,alpha-trehalase activity mitochondrion|cytoplasm
YPL256C YPL256C CLN2 hom Verified 0.656054659294213 0.255894478014724 no 1277 0.244150152711782 829 NA FT CELL CYCLE|SIGNALING|CELL DIVISION|PROTEIN PHOSPHORYLATION NUCLEUS G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p) regulation of cyclin-dependent protein kinase activity|re-entry into mitotic cell cycle after pheromone arrest cyclin-dependent protein kinase regulator activity cyclin-dependent protein kinase holoenzyme complex|nucleus|cytoplasm
YGR200C YGR200C ELP2 hom Verified 0.65586137904534 0.25595665980567 no 1278 0.27431952494097 922 NA FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin regulation of transcription from RNA polymerase II promoter|protein urmylation|tRNA wobble uridine modification molecular_function Elongator holoenzyme complex|nucleus|cytoplasm
YNL296W_d YNL296W YNL296W hom Dubious 0.655066895535347 0.256212342465303 no 1279 0.293954280078705 1016 NA Dubious open reading frame unlikely to encode a functional protein; deletion adversely affects sporulation; deletion mutant exhibits synthetic phenotype under expression of mutant huntingtin fragment, but gene does not have human ortholog Unknown Unknown Unknown
YLR151C YLR151C PCD1 hom Verified 0.653328378657111 0.256772300465055 no 1280 0.255464720880766 870 NA FT NUCLEOTIDE METABOLISM Peroxisomal pyrophosphatase with specificity for coenzyme A and CoA derivatives, may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids; nudix hydrolase family member biological_process pyrophosphatase activity peroxisome
YDR450W YDR450W RPS18A hom Verified 0.653146957151144 0.256830771109666 no 1281 0.268830114497266 925 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION MITOCHONDRION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18A has a paralog, RPS18B, that arose from the whole genome duplication; protein increases in abundance and relocalizes from cytoplasm to nuclear foci upon DNA replication stress endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|cytoplasmic translation|rRNA export from nucleus structural constituent of ribosome cytosolic small ribosomal subunit|mitochondrion
YKL107W_p YKL107W YKL107W hom Uncharacterized 0.652905770412496 0.256908514320914 no 1282 0.235887539099434 810 NA FT OXIDATION-REDUCTION PROCESS Putative short-chain dehydrogenase/reductase; proposed to be a palmitoylated membrane protein biological_process molecular_function cellular_component
YLR104W_p YLR104W LCL2 hom Uncharacterized 0.652002485445508 0.257199784513848 no 1283 0.257588065012197 858 NA FT PROTEOLYSIS Putative protein of unknown function; mutant is deficient in amounts of cell wall mannosylphosphate and has long chronological lifespan; genetic interactions suggest a role in ER-associated protein degradation (ERAD) ER-associated protein catabolic process molecular_function cellular_component
YLL054C_p YLL054C YLL054C hom Uncharacterized 0.651758638116681 0.257278444112123 no 1284 0.261904113897982 874 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene biological_process sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity cellular_component
YGR004W YGR004W PEX31 hom Verified 0.650756774557273 0.257601753669681 no 1285 0.2240987268706 766 NA FT PEROXISOME ORGANIZATION Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex30p and Pex32p; probably acts at a step downstream of steps mediated by Pex28p and Pex29p peroxisome organization molecular_function integral to membrane|integral to peroxisomal membrane
YBL107C YBL107C MIC23 hom Verified 0.650608223530993 0.25764971025454 no 1286 0.262477971389315 883 NA Mitochondrial intermembrane space protein of unknown function; imported via the MIA import machinery; contains an unusual twin cysteine motif (CX13C CX14C) biological_process molecular_function cytoplasm
YDR409W YDR409W SIZ1 hom Verified 0.65049295970275 0.257686923958884 no 1287 0.256814007417194 855 NA FT CHROMOSOME SEGREGATION NUCLEUS|SITE OF POLARIZED GROWTH|CHROMOSOME|CYTOSKELETON SUMO/Smt3 ligase that promotes the attachment of sumo (Smt3p; small ubiquitin-related modifier) to proteins; binds Ubc9p and may bind septins; specifically required for sumoylation of septins in vivo; localized to the septin ring protein sumoylation|chromosome segregation SUMO ligase activity nuclear chromatin|septin ring
YGR112W YGR112W SHY1 hom Verified 0.650349382116509 0.257733282853573 no 1288 0.231675250804439 790 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome mitochondrial respiratory chain complex IV assembly|aerobic respiration unfolded protein binding mitochondrion|integral to membrane|mitochondrial inner membrane
YER092W YER092W IES5 hom Verified 0.648855656932816 0.25821583939513 no 1289 0.264714640338135 924 NA FT NUCLEUS Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions biological_process molecular_function nucleus
YCR101C_p YCR101C YCR101C hom Uncharacterized 0.648558055336088 0.258312037228988 no 1290 0.259334299596502 915 NA Putative protein of unknown function; localizes to the membrane fraction; YCR101C is not an essential gene biological_process molecular_function integral to membrane|membrane
YER077C_p YER077C YER077C hom Uncharacterized 0.648546352962288 0.258315820326782 no 1291 0.294316628839537 1016 NA FT MITOCHONDRION Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport biological_process molecular_function mitochondrion
YGR141W YGR141W VPS62 hom Verified 0.648493829278335 0.258332800332255 no 1292 0.238937402548879 820 NA FT PROTEIN LOCALIZATION|VACUOLAR TRANSPORT Vacuolar protein sorting (VPS) protein required for cytoplasm to vacuole targeting of proteins protein targeting to vacuole molecular_function cellular_component
YKL151C YKL151C YKL151C hom Verified 0.647968469407645 0.258502671980979 no 1293 0.224360641553035 741 NA FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM NADHX dehydratase; converts (S)-NADHX to NADH in an ATP-dependent manner; homologous to Carkd in mammals, and the C-terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; YKL151C promoter contains STREs (stress response elements) and expression is induced by heat shock or methyl methanesulfonate; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress nicotinamide nucleotide metabolic process ATP-dependent NAD(P)H-hydrate dehydratase activity cytoplasm
YJR107W_p YJR107W YJR107W hom Uncharacterized 0.647448762652157 0.258670772639086 no 1294 0.247706736613674 842 NA FT LIPID METABOLISM Putative lipase biological_process lipase activity cellular_component
YMR230W-A_p YMR230W-A YMR230W-A hom Uncharacterized 0.645954519588487 0.259154404960748 no 1295 0.257187044475832 887 NA Putative protein of unknown function biological_process molecular_function cellular_component
YMR163C YMR163C INP2 hom Verified 0.645739732596027 0.259223962131475 no 1296 0.24681397787053 845 NA FT PEROXISOME ORGANIZATION Peroxisome-specific receptor important for peroxisome inheritance; co-fractionates with peroxisome membranes and co-localizes with peroxisomes in vivo; physically interacts with the myosin V motor Myo2p; INP2 is not an essential gene peroxisome inheritance protein anchor peroxisome|integral to peroxisomal membrane|cytoplasm
YGR287C YGR287C IMA1 hom Verified 0.644297862417031 0.259691150753185 no 1297 0.260489280717704 905 NA FT CARBOHYDRATE METABOLISM MITOCHONDRION Major isomaltase (alpha-1,6-glucosidase/alpha-methylglucosidase); required for isomaltose utilization; specificity for isomaltose, alpha-methylglucoside, and palatinose; member of the IMA isomaltase family disaccharide catabolic process oligo-1,6-glucosidase activity mitochondrion|ribosome
YLR288C YLR288C MEC3 hom Verified 0.644241479292376 0.259709428598132 no 1298 0.240562498846326 776 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|GENE SILENCING NUCLEUS|CHROMOSOME DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1 telomere maintenance via recombination|DNA damage checkpoint|DNA metabolic process|chromatin silencing at telomere DNA binding nucleus|checkpoint clamp complex
YLR079W YLR079W SIC1 hom Verified 0.6425587887204 0.260255215633034 no 1299 0.270985410347037 918 NA FT CELL CYCLE|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS NUCLEUS Cyclin-dependent kinase inhibitor (CKI); inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1 regulation of cyclin-dependent protein kinase activity|negative regulation of macroautophagy|G1/S transition of mitotic cell cycle cyclin-dependent protein kinase inhibitor activity nucleus|cytoplasm
YDR017C YDR017C KCS1 hom Verified 0.64132307084276 0.260656401451773 no 1300 0.235914489876371 813 NA Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response and telomere maintenance inositol phosphate biosynthetic process inositol heptakisphosphate kinase activity|inositol hexakisphosphate kinase activity|inositol-1,3,4,5,6-pentakisphosphate kinase activity|inositol heptakisphosphate 5-kinase activity cytoplasm
YGL175C YGL175C SAE2 hom Verified 0.640897273955114 0.260794713559099 no 1301 0.242443317034186 842 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS Endonuclease that processes hairpin DNA structures with the MRX complex; involved in meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents DNA double-strand break processing|DNA catabolic process, endonucleolytic|meiotic DNA double-strand break formation|meiotic DNA double-strand break processing|gene conversion at mating-type locus, DNA double-strand break processing double-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity nucleus|cytoplasm
YBL044W_p YBL044W YBL044W hom Uncharacterized 0.640213689759111 0.26101684196616 no 1302 0.253788401344984 871 NA Putative protein of unknown function; YBL044W is not an essential protein biological_process molecular_function cellular_component
YNR067C YNR067C DSE4 hom Verified 0.639876199906257 0.261126544025824 no 1303 0.219532179693675 756 NA FT CELL WALL ORG/BIOGENESIS|CELL DIVISION Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother cytokinesis, completion of separation glucan endo-1,3-beta-D-glucosidase activity fungal-type cell wall|extracellular region|cell septum
YBR213W YBR213W MET8 hom Verified 0.636714729348953 0.262155338759426 no 1304 0.284451725557962 967 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM Bifunctional dehydrogenase and ferrochelatase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis siroheme biosynthetic process|sulfate assimilation precorrin-2 dehydrogenase activity|ferrochelatase activity cellular_component
YDL125C YDL125C HNT1 hom Verified 0.635625250439401 0.262510353781974 no 1305 0.253665799043369 878 NA FT NUCLEOTIDE METABOLISM NUCLEUS Adenosine 5'-monophosphoramidase; interacts physically and genetically with Kin28p, a CDK and TFIIK subunit, and genetically with CAK1; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins and similar to Hint; protein abundance increases in response to DNA replication stress nucleotide metabolic process hydrolase activity|nucleotide binding nucleus|cytoplasm
YER164W YER164W CHD1 hom Verified 0.635236991665732 0.262636930319889 no 1306 0.282407883704359 941 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION NUCLEUS|MITOCHONDRION|CHROMOSOME HISTONE ACETYLTRANSFERASE Chromatin remodeler that regulates various aspects of transcription; acts in in conjunction with Isw1b to regulate chromatin structure and maintain chromatin integrity during transcription elongation by RNAP II by preventing trans-histone exchange over coding regions; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SLIK complexes termination of RNA polymerase I transcription|ATP-dependent chromatin remodeling|nucleosome positioning|negative regulation of histone H3-K14 acetylation|termination of RNA polymerase II transcription|regulation of transcription by chromatin organization|regulation of transcriptional start site selection at RNA polymerase II promoter|nucleosome mobilization|Unknown|transcription elongation from RNA polymerase II promoter chromatin DNA binding|DNA-dependent ATPase activity|methylated histone residue binding|DNA binding|rDNA binding nuclear chromatin|SLIK (SAGA-like) complex|mitochondrion|SAGA complex|nucleolar chromatin
YER178W YER178W PDA1 hom Verified 0.634445752054216 0.262894979583695 no 1307 0.281370075953382 969 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose acetyl-CoA biosynthetic process from pyruvate pyruvate dehydrogenase (acetyl-transferring) activity mitochondrial nucleoid|mitochondrion|mitochondrial pyruvate dehydrogenase complex
YEL024W YEL024W RIP1 hom Verified 0.634156901004763 0.26298921570239 no 1308 0.2856181557947 961 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Ubiquinol-cytochrome-c reductase, a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration; during import, Rip1p is first imported into the mitochondrial matrix where it is processed, acquires its Fe-S cluster, and is folded, then is translocated into the inner membrane by the action of a homo-oligomer of Bcs1p, and finally is delivered by Bcs1p to Complex III for assembly mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration ubiquinol-cytochrome-c reductase activity mitochondrion|mitochondrial respiratory chain complex III
YBL071C_d YBL071C YBL071C hom Dubious 0.634077989259682 0.263014963242083 no 1309 0.257611415449575 864 NA Dubious open reading frame, predicted protein contains a peroxisomal targeting signal Unknown Unknown Unknown
YAR035C-A_p YAR035C-A YAR035C-A hom Uncharacterized 0.633586131677648 0.263175476914847 no 1310 0.244521503910788 860 NA Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; predicted to have a role in cell budding based on computational guilt by association analysis biological_process molecular_function cellular_component
YDR148C YDR148C KGD2 hom Verified 0.633237262904154 0.263289357695671 no 1311 0.264955513525509 946 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated tricarboxylic acid cycle|mitochondrial genome maintenance|2-oxoglutarate metabolic process dihydrolipoyllysine-residue succinyltransferase activity mitochondrial nucleoid|mitochondrion|mitochondrial oxoglutarate dehydrogenase complex
YGL230C_p YGL230C YGL230C hom Uncharacterized 0.632878527389736 0.26340648550226 no 1312 0.244663878660091 818 NA Putative protein of unknown function; non-essential gene biological_process molecular_function cellular_component
YOL055C YOL055C THI20 hom Verified 0.632657511682485 0.263478660778639 no 1313 0.245177046109781 847 NA Trifunctional enzyme of thiamine biosynthesis, degradation and salvage; has hydroxymethylpyrimidine (HMP) kinase, HMP-phosphate (HMP-P) kinase and thiaminase activities; member of a gene family with THI21 and THI22; HMP and HMP-P kinase activity redundant with Thi21p thiamine biosynthetic process|thiamine catabolic process phosphomethylpyrimidine kinase activity|thiaminase activity|hydroxymethylpyrimidine kinase activity cytosol
YEL046C YEL046C GLY1 hom Verified 0.632573347152408 0.26350614834858 no 1314 0.299793361635265 1008 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Threonine aldolase, catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis threonine catabolic process|glycine biosynthetic process threonine aldolase activity|L-allo-threonine aldolase activity cytosol
YDR298C YDR298C ATP5 hom Verified 0.631922008138267 0.263718920771802 no 1315 0.274882633405168 949 NA FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS MITOCHONDRION Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated ATP synthesis coupled proton transport hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase, stator stalk|mitochondrial proton-transporting ATP synthase complex
YDR072C YDR072C IPT1 hom Verified 0.63109114122394 0.263990466567939 no 1316 0.262987467660203 930 NA FT LIPID METABOLISM Inositolphosphotransferase, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin mannosyl diphosphorylinositol ceramide metabolic process|sphingolipid biosynthetic process transferase activity, transferring phosphorus-containing groups integral to membrane
YPR149W YPR149W NCE102 hom Verified 0.630752880714959 0.264101058430083 no 1317 0.249935302983948 880 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION ENDOPLASMIC RETICULUM|MITOCHONDRION|PLASMA MEMBRANE Protein of unknown function; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs) eisosome assembly|protein secretion|negative regulation of protein phosphorylation|plasma membrane organization|establishment of protein localization to plasma membrane molecular_function mitochondrion|integral to membrane|membrane raft|endoplasmic reticulum|cellular bud membrane|plasma membrane|mating projection membrane|cytoplasm
YFR025C YFR025C HIS2 hom Verified 0.630380078213732 0.264222970886022 no 1318 0.23795925259758 782 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Histidinolphosphatase, catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control histidine biosynthetic process histidinol-phosphatase activity intracellular
YPL270W YPL270W MDL2 hom Verified 0.63000817846472 0.264344616677059 no 1319 0.272101399289747 940 NA FT NUCLEOTIDE METABOLISM MITOCHONDRION Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, required for respiratory growth at high temperature; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis oligopeptide transport|oligopeptide export from mitochondrion oligopeptide-transporting ATPase activity mitochondrion|integral to membrane|mitochondrial inner membrane
YPL097W YPL097W MSY1 hom Verified 0.628789562225614 0.264743417150079 no 1320 0.276632184443832 942 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial tyrosyl-tRNA synthetase mitochondrial tyrosyl-tRNA aminoacylation tyrosine-tRNA ligase activity mitochondrion
YJR004C YJR004C SAG1 hom Verified 0.628743242531652 0.264758581618667 no 1321 0.265344622433135 887 NA Alpha-agglutinin of alpha-cells, binds to Aga1p during agglutination, N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin, C-terminal half is highly glycosylated and contains GPI anchor agglutination involved in conjugation with cellular fusion cell adhesion molecule binding fungal-type cell wall
YNL119W YNL119W NCS2 hom Verified 0.626797987374723 0.265395831484232 no 1322 0.253506258752151 890 NA FT RNA PROCESSING Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae tRNA wobble position uridine thiolation|pseudohyphal growth|protein urmylation|invasive growth in response to glucose limitation molecular_function cytosol|cytoplasm
YOR242C YOR242C SSP2 hom Verified 0.626069325714166 0.265634735389278 no 1323 0.247636272009252 844 NA FT CELL WALL ORG/BIOGENESIS Sporulation specific protein that localizes to the spore wall; required for sporulation at a point after meiosis II and during spore wall formation; SSP2 expression is induced midway in meiosis ascospore wall assembly|ascospore formation molecular_function ascospore wall
YPL023C YPL023C MET12 hom Verified 0.62599897018055 0.265657808399097 no 1324 0.273727326086652 935 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS Protein with methylenetetrahydrofolate reductase (MTHFR) activity in vitro; null mutant has no phenotype and is prototrophic for methionine; MET13 encodes major isozyme of MTHFR biological_process methylenetetrahydrofolate reductase (NADPH) activity cellular_component
YOR097C_p YOR097C YOR097C hom Uncharacterized 0.625854177953103 0.265705296027805 no 1325 0.284153781794613 998 NA Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; YOR097C is not an essential gene biological_process molecular_function cellular_component
YLR363W-A YLR363W-A YLR363W-A hom Verified 0.62526058192479 0.265900023195931 no 1326 0.227526933661623 787 NA FT NUCLEUS Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; relocalizes from nucleus to nucleolus upon DNA replication stress biological_process molecular_function nucleus
YGR178C YGR178C PBP1 hom Verified 0.625097054701852 0.265953680449753 no 1327 0.274508563568277 976 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION NUCLEUS|MITOCHONDRION Component of glucose deprivation induced stress granules; involved in P-body-dependent granule assembly; similar to human ataxin-2; interacts with Pab1p to regulate mRNA polyadenylation; interacts with Mkt1p to regulate HO translation; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress positive regulation of translation|mRNA polyadenylation|stress granule assembly molecular_function mitochondrion|nucleus|polysome|cytoplasmic stress granule|cytoplasm
YPL022W YPL022W RAD1 hom Verified 0.624911839341256 0.266014460732891 no 1328 0.266257474355954 899 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein mitotic recombination|meiotic mismatch repair|nucleotide-excision repair, DNA incision, 5'-to lesion|double-strand break repair via single-strand annealing, removal of nonhomologous ends|removal of nonhomologous ends single-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity nucleotide-excision repair factor 1 complex|nucleus
YER014C-A YER014C-A BUD25 hom Verified 0.624792109663399 0.266053754974672 no 1329 0.248209630762294 814 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern cellular bud site selection molecular_function cellular_component
YJL134W YJL134W LCB3 hom Verified 0.624007211843177 0.266311424415657 no 1330 0.258553351043963 861 NA FT LIPID METABOLISM|SIGNALING ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Long-chain base-1-phosphate phosphatase; specific for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids; LCB3 has a paralog, YSR3, that arose from the whole genome duplication calcium-mediated signaling|sphingolipid biosynthetic process sphingosine-1-phosphate phosphatase activity integral to membrane|endoplasmic reticulum
YIL099W YIL099W SGA1 hom Verified 0.624001462658288 0.266313312247215 no 1331 0.26143197078438 892 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation ascospore formation|glycogen catabolic process glucan 1,4-alpha-glucosidase activity fungal-type vacuole
YLR056W YLR056W ERG3 hom Verified 0.623094809523785 0.266611110201911 no 1332 0.311047567461989 1075 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM C-5 sterol desaturase, glycoprotein that catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources; substrate of the HRD ubiquitin ligase ergosterol biosynthetic process C-5 sterol desaturase activity integral to membrane|endoplasmic reticulum|endoplasmic reticulum lumen
YNR075W YNR075W COS10 hom Verified 0.622838438967141 0.266695347824237 no 1333 0.240820089125005 841 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins endocytosis molecular_function nuclear envelope|integral to membrane|endoplasmic reticulum|cytoplasm
YCR022C_d YCR022C YCR022C hom Dubious 0.621074845923002 0.267275189367035 no 1334 0.252603031651854 842 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR022C is not an essential gene Unknown Unknown Unknown
YKL216W YKL216W URA1 hom Verified 0.620121330396558 0.267588954950784 no 1335 0.254737008518576 893 NA FT OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid 'de novo' pyrimidine nucleobase biosynthetic process dihydroorotate dehydrogenase activity extrinsic to membrane|cytoplasm
YOR215C YOR215C AIM41 hom Verified 0.61979291581287 0.267697066637786 no 1336 0.260823804177682 881 NA FT MITOCHONDRION Putative protein of unknown function; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss biological_process molecular_function mitochondrion
YDL069C YDL069C CBS1 hom Verified 0.618250116485559 0.268205239351392 no 1337 0.275792083860759 943 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial translational activator of the COB mRNA; membrane protein that interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader mitochondrial respiratory chain complex III biogenesis|positive regulation of mitochondrial translation translation regulator activity extrinsic to mitochondrial inner membrane|mitochondrion|mitochondrial ribosome
YPR148C YPR148C YPR148C hom Verified 0.616533782339886 0.268771141378319 no 1338 0.255476800358661 882 NA Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern biological_process molecular_function ribosome|cytoplasm
YKL133C_p YKL133C YKL133C hom Uncharacterized 0.616303000452007 0.26884727947134 no 1339 0.286402736055832 984 NA Putative protein of unknown function; has similarity to Mgr3p, but unlike MGR3, is not required for growth of cells lacking the mitochondrial genome (null mutation does not confer a petite-negative phenotype) biological_process molecular_function cellular_component
YOR192C YOR192C THI72 hom Verified 0.613857422113248 0.269654774090927 no 1340 0.287828521527065 1003 NA Transporter of thiamine or related compound; shares sequence similarity with Thi7p thiamine transport transporter activity integral to membrane|membrane
YLR426W_p YLR426W TDA5 hom Uncharacterized 0.613789139733998 0.269677337368518 no 1341 0.321072842463014 1085 NA FT OXIDATION-REDUCTION PROCESS MITOCHONDRION Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele response to drug molecular_function mitochondrion|integral to membrane
YLR061W YLR061W RPL22A hom Verified 0.613372268972065 0.269815108945193 no 1342 0.270033645201105 917 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YPR024W YPR024W YME1 hom Verified 0.612956723139106 0.269952477710728 no 1343 0.242617999269503 840 NA FT PROTEOLYSIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover chronological cell aging|misfolded or incompletely synthesized protein catabolic process|mitochondrion organization ATP-dependent peptidase activity mitochondrion|mitochondrial inner membrane|i-AAA complex
YHR168W YHR168W MTG2 hom Verified 0.612776240613536 0.270012151492968 no 1344 0.261729583168147 887 NA FT TRANSLATION|NUCLEOTIDE METABOLISM MITOCHONDRION Putative GTPase, member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly cytoplasmic translation ribosome binding|GTPase activity mitochondrial inner membrane|extrinsic to membrane
YDL240W YDL240W LRG1 hom Verified 0.612681595388761 0.270043447124748 no 1345 0.275134166456696 938 NA FT SIGNALING|CELL WALL ORG/BIOGENESIS MITOCHONDRION|SITE OF POLARIZED GROWTH Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity; appears to specifically regulate 1,3-beta-glucan synthesis fungal-type cell wall biogenesis|small GTPase mediated signal transduction Rho GTPase activator activity mitochondrion|cellular bud neck|cytoplasm
YJL133W YJL133W MRS3 hom Verified 0.61079254047555 0.270668466213127 no 1346 0.252798253821637 863 NA FT RNA PROCESSING|ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Iron transporter, mediates Fe2+ transport across inner mito membrane; mitochondrial carrier family member; active under low-iron conditions; may transport other cations; MRS3 has a paralog, MRS4, that arose from the whole genome duplication mitochondrial iron ion transport|RNA splicing iron ion transmembrane transporter activity mitochondrion|integral to membrane
YBR150C YBR150C TBS1 hom Verified 0.610084308189872 0.270902980390921 no 1347 0.250899421183099 863 NA FT TRANSCRIPTION FROM RNA POL II ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; TBS1 has a paralog, HAL9, that arose from the whole genome duplication biological_process sequence-specific DNA binding mitochondrion|nucleus|cytoplasm
YNL083W YNL083W SAL1 hom Verified 0.609866871982291 0.270974999527127 no 1348 0.259970305413635 893 NA FT MITOCHONDRION ADP/ATP transporter; member of the Ca2+-binding subfamily of mitochondrial carriers, with two EF-hand motifs; transport activity of either Sal1p or Pet9p is critical for viability; polymorphic in different S. cerevisiae strains ATP transport|ADP transport|mitochondrial transport ATP:ADP antiporter activity|calcium ion binding mitochondrion|integral to membrane|mitochondrial inner membrane
YDR496C YDR496C PUF6 hom Verified 0.609626161787743 0.271054738603228 no 1349 0.247754283495115 830 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION NUCLEUS|SITE OF POLARIZED GROWTH RIBOSOME Pumilio-homology domain protein that binds the 3' UTR of ASH1 mRNA and represses its translation, resulting in proper asymmetric localization of ASH1 mRNA; also co-sediments with the 60S ribosomal subunit and is required for its biogenesis ribosomal large subunit biogenesis|negative regulation of translation mRNA 3'-UTR binding|translation repressor activity, nucleic acid binding nucleolus|nucleus|large ribosomal subunit
YER007C-A YER007C-A TMA20 hom Verified 0.609621691259287 0.271056219647496 no 1350 0.258885851491737 902 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; interacts with Tma22p; null mutant exhibits translation defects; has homology to human oncogene MCT-1; protein abundance increases in response to DNA replication stress ribosome biogenesis RNA binding ribosome|cytoplasm
YOR222W YOR222W ODC2 hom Verified 0.608625966766406 0.271386194394408 no 1351 0.253354895209141 874 NA FT MITOCHONDRION Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism mitochondrial transport dicarboxylic acid transmembrane transporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YNL148C YNL148C ALF1 hom Verified 0.607895898048087 0.271628260157185 no 1352 0.312288858023553 1042 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS NUCLEUS|CYTOSKELETON Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance protein folding|post-chaperonin tubulin folding pathway microtubule binding|alpha-tubulin binding nucleus|cytoplasm
YIL100W_d YIL100W YIL100W hom Dubious 0.60775351009369 0.271675483647092 no 1353 0.279763977559932 937 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YIL100C-A Unknown Unknown Unknown
YNL209W YNL209W SSB2 hom Verified 0.607632193831706 0.271715721856878 no 1354 0.211098569739442 689 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RESPONSE TO NUTRIENT LEVELS Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; SSB2 has a paralog, SSB1, that arose from the whole genome duplication cellular response to glucose starvation|cytoplasmic translation|ribosomal subunit export from nucleus|rRNA processing|regulation of translational fidelity|'de novo' cotranslational protein folding unfolded protein binding|ATPase activity plasma membrane|polysome|cytoplasm
YDR179C YDR179C CSN9 hom Verified 0.607353311196985 0.271808232969319 no 1355 0.269096154411224 886 NA FT SIGNALING NUCLEUS Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|cullin deneddylation molecular_function signalosome
YJL051W YJL051W IRC8 hom Verified 0.607273669661513 0.271834654583337 no 1356 0.247038003905673 811 NA Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52p foc mitotic recombination molecular_function integral to membrane|cellular bud
YMR316W YMR316W DIA1 hom Verified 0.604351677577316 0.272804927730742 no 1357 0.290603605152299 995 NA Protein of unknown function, involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern pseudohyphal growth|invasive growth in response to glucose limitation molecular_function cytoplasm
YGR121W-A_p YGR121W-A YGR121W-A hom Uncharacterized 0.604048234161438 0.272905787166822 no 1358 0.267910443913942 910 NA Putative protein of unknown function biological_process molecular_function cellular_component
YMR026C YMR026C PEX12 hom Verified 0.601662017946171 0.273699568783238 no 1359 0.293591586989212 977 NA FT PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION C3HC4-type RING-finger peroxin and E3 ubiquitin ligase, required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder protein import into peroxisome matrix ubiquitin-protein ligase activity|protein binding integral to peroxisomal membrane
YIL152W_p YIL152W YIL152W hom Uncharacterized 0.600600404146157 0.274053084361341 no 1360 0.251373490344396 835 NA Putative protein of unknown function biological_process molecular_function cellular_component
YHR131C_p YHR131C YHR131C hom Uncharacterized 0.60042676617283 0.274110926971362 no 1361 0.250268567168583 840 NA Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; overexpression causes cell cycle delay or arrest; contains a PH domain and binds phosphatidylinositols and other lipids in a large-scale study biological_process molecular_function cytoplasm
YBL052C YBL052C SAS3 hom Verified 0.600196429562797 0.274187666444482 no 1362 0.270680377112231 919 NA FT CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS HISTONE ACETYLTRANSFERASE Histone acetyltransferase catalytic subunit of NuA3 complex that acetylates histone H3, involved in transcriptional silencing; homolog of the mammalian MOZ proto-oncogene; mutant has aneuploidy tolerance; sas3gcn5 double mutation is lethal histone acetylation|chromatin modification|chromatin silencing at telomere|chromatin silencing at silent mating-type cassette histone acetyltransferase activity NuA3 histone acetyltransferase complex
YPR189W YPR189W SKI3 hom Verified 0.599852640198201 0.274302223832179 no 1363 0.251925844038024 888 NA FT NUCLEUS Ski complex component and TPR protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, non-stop decay molecular_function Ski complex
YMR204C YMR204C INP1 hom Verified 0.598499498590124 0.274753346693332 no 1364 0.260521794904224 869 NA FT PEROXISOME ORGANIZATION Peripheral membrane protein of peroxisomes involved in peroxisomal inheritance; recruitment to peroxisomes is mediated by interaction with Pex3p at the peroxisomal membrane peroxisome inheritance molecular_function peroxisome|extrinsic to intraperoxisomal membrane
YLR135W YLR135W SLX4 hom Verified 0.597741556621347 0.275006196128337 no 1365 0.262186775191618 879 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Endonuclease involved in processing DNA; acts during recombination and repair; cleaves branched structures in a complex with Slx1p; involved interstrand cross-link repair and in Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during DSBR via single-strand annealing; relative distribution to nuclear foci increases upon DNA replication stress double-strand break repair via single-strand annealing, removal of nonhomologous ends|DNA replication|response to DNA damage stimulus|DNA-dependent DNA replication 5'-flap endonuclease activity Slx1-Slx4 complex|nucleus
YOR364W_d YOR364W YOR364W hom Dubious 0.597171637219753 0.275196396711396 no 1366 0.255111818941199 822 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C Unknown Unknown Unknown
YDR297W YDR297W SUR2 hom Verified 0.59692408451792 0.275279033245737 no 1367 0.289657144254503 997 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis sphingolipid metabolic process sphingosine hydroxylase activity integral to membrane|endoplasmic reticulum membrane
YOR008C-A_p YOR008C-A YOR008C-A hom Uncharacterized 0.59612228335244 0.275546769440772 no 1368 0.262751101482017 889 NA Putative protein of unknown function, includes a potential transmembrane domain; deletion results in slightly lengthened telomeres biological_process molecular_function cellular_component
YLR380W YLR380W CSR1 hom Verified 0.595914021609277 0.2756163328233 no 1369 0.252237554041779 860 NA FT KETONE METABOLISM|LIPID METABOLISM|CELL WALL ORG/BIOGENESIS MITOCHONDRION Phosphatidylinositol transfer protein; has a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance; protein abundance increases in response to DNA replication stress phosphatidylinositol metabolic process|Golgi to plasma membrane protein transport|Golgi to plasma membrane transport|Unknown|negative regulation of fatty acid biosynthetic process|phospholipid transport phosphatidylinositol transporter activity|phosphatidylcholine transporter activity cytosol|endosome|mitochondrion|lipid particle
YGR053C_p YGR053C YGR053C hom Uncharacterized 0.594894490005476 0.275957000318358 no 1370 0.274600593205457 933 NA Putative protein of unknown function biological_process molecular_function cellular_component
YMR167W YMR167W MLH1 hom Verified 0.59448513237207 0.276093841727774 no 1371 0.251701077816007 869 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION|CHROMOSOME Protein required for mismatch repair in mitosis and meiosis as well as crossing over during meiosis; forms a complex with Pms1p and Msh2p-Msh3p during mismatch repair; human homolog is associated with hereditary non-polyposis colon cancer mismatch repair|meiotic mismatch repair|reciprocal meiotic recombination|meiotic heteroduplex formation double-stranded DNA binding|DNA insertion or deletion binding|loop DNA binding|single-stranded DNA binding|dinucleotide insertion or deletion binding|ATPase activity|ATP binding mitochondrion|nucleus|MutLalpha complex|MutLbeta complex|cytoplasm
YIL010W YIL010W DOT5 hom Verified 0.59355171023633 0.276405993665537 no 1372 0.24297481255405 809 NA FT OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS NUCLEUS|CHROMOSOME Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth cellular response to oxidative stress|cell redox homeostasis thioredoxin peroxidase activity nucleus
YBL038W YBL038W MRPL16 hom Verified 0.592216249890621 0.276852894646662 no 1373 0.300701730666321 1030 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome|peptidyltransferase activity mitochondrion|mitochondrial large ribosomal subunit
YGL049C YGL049C TIF4632 hom Verified 0.59200501561878 0.276923614884083 no 1374 0.255212263132317 880 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION RIBOSOME Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); TIF4632 has a paralog, TIF4631, that arose from the whole genome duplication translational initiation|stress granule assembly translation initiation factor binding|mRNA binding|translation initiation factor activity eukaryotic translation initiation factor 4F complex|cytoplasmic stress granule
YGR242W_d YGR242W YGR242W hom Dubious 0.591724408627566 0.277017574458326 no 1375 0.278917195008179 942 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C Unknown Unknown Unknown
YLR313C YLR313C SPH1 hom Verified 0.591187380412168 0.277197438646718 no 1376 0.300939043492723 1012 NA FT CELL CYCLE|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Protein involved in shmoo formation and bipolar bud site selection; homologous to Spa2p, localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p bipolar cellular bud site selection|pseudohyphal growth|invasive filamentous growth|mating projection assembly molecular_function incipient cellular bud site|cellular bud neck|cellular bud tip|mating projection
YBL098W YBL098W BNA4 hom Verified 0.590490612607516 0.277430888738279 no 1377 0.266237289344083 930 NA FT OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM MITOCHONDRION Kynurenine 3-mono oxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; putative therapeutic target for Huntington disease de novo NAD biosynthetic process from tryptophan kynurenine 3-monooxygenase activity mitochondrial outer membrane|mitochondrion
YGL197W YGL197W MDS3 hom Verified 0.589349769025889 0.277813332558519 no 1378 0.300526447717536 1021 NA FT CELL CYCLE|SIGNALING MITOCHONDRION Putative component of the TOR regulatory pathway; negative regulator of early meiotic gene expression; required, with Pmd1p, for growth under alkaline conditions; has an N-terminal kelch-like domain TOR signaling cascade|negative regulation of sporulation resulting in formation of a cellular spore molecular_function mitochondrion|cytoplasm
YBR042C YBR042C CST26 hom Verified 0.588738458379582 0.278018367461976 no 1379 0.264359697013969 941 NA FT LIPID METABOLISM Putative transferase involved in phospholipid biosynthesis; required for incorporation of stearic acid into phosphatidylinositol; affects chromosome stability when overexpressed; CST26 has a paralog, YDR018C, that arose from the whole genome duplication phospholipid biosynthetic process transferase activity, transferring acyl groups lipid particle
YIL162W YIL162W SUC2 hom Verified 0.588632257505709 0.2780539949893 no 1380 0.273821141364411 926 NA FT CARBOHYDRATE METABOLISM MITOCHONDRION Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively sucrose catabolic process beta-fructofuranosidase activity mitochondrion|extracellular region|cytoplasm
YJR047C YJR047C ANB1 hom Verified 0.587975763560215 0.278274280420932 no 1381 0.282106601198288 961 NA FT KETONE METABOLISM|PROTEIN COMPLEX ORG/BIOGENESIS|AMINO ACID METABOLISM|TRANSLATION RIBOSOME Translation elongation factor eIF-5A; previously thought to function in translation initiation; undergoes an essential hypusination modification; expressed under anaerobic conditions; ANB1 has a paralog, HYP2, that arose from the whole genome duplication translational frameshifting|positive regulation of translational termination|positive regulation of translational elongation ribosome binding|RNA binding|translation elongation factor activity cytosolic ribosome
YDR169C YDR169C STB3 hom Verified 0.587725771095148 0.278358187331806 no 1382 0.260674755520496 891 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS NUCLEUS Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress positive regulation of transcription from RNA polymerase II promoter by glucose sequence-specific DNA binding nucleus|cytoplasm
YAL046C YAL046C AIM1 hom Verified 0.58760880566877 0.278397449579378 no 1383 0.286599562686682 992 NA Protein involved in mitochondrial function or organization; null mutant displays elevated frequency of mitochondrial genome loss biological_process molecular_function cellular_component
YDR274C_d YDR274C YDR274C hom Dubious 0.587605805874682 0.278398456567625 no 1384 0.256253039027851 846 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPL167C YPL167C REV3 hom Verified 0.587560718701877 0.278413591904663 no 1385 0.280245731300212 953 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION|CHROMOSOME Catalytic subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair error-prone translesion synthesis|error-free translesion synthesis DNA-directed DNA polymerase activity nuclear chromatin|mitochondrion|zeta DNA polymerase complex
YPR076W_d YPR076W YPR076W hom Dubious 0.587514455299096 0.278429122507756 no 1386 0.29089544977663 996 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOL124C YOL124C TRM11 hom Verified 0.586667668040634 0.278713463155233 no 1387 0.28066346728309 941 NA FT RNA PROCESSING Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain tRNA methylation S-adenosylmethionine-dependent methyltransferase activity|RNA binding|tRNA (guanine-N2-)-methyltransferase activity cytoplasm|tRNA (m2G10) methyltransferase complex
YHR015W YHR015W MIP6 hom Verified 0.586460323786259 0.278783108320386 no 1388 0.254705942901388 836 NA FT RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE Putative RNA-binding protein; interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export; MIP6 has a paralog, PES4, that arose from the whole genome duplication mRNA export from nucleus RNA binding nuclear pore
YGR071C YGR071C ENV11 hom Verified 0.585366533742253 0.279150643194508 no 1389 0.265083398670988 913 NA FT VACUOLAR PROTEIN PROCESSING NUCLEUS Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and fragmented vacuoles; deletion mutant has increased glycogen accumulation and displays elongated buds; green fluorescent protein (GFP)-fusion protein localizes to the nucleus vacuole organization|vacuolar protein processing molecular_function nucleus
YJL066C YJL066C MPM1 hom Verified 0.584634492779499 0.279396754802554 no 1390 0.292141852909802 988 NA FT MITOCHONDRION Mitochondrial intermembrane space protein of unknown function biological_process molecular_function mitochondrion|extrinsic to membrane
YFL044C YFL044C OTU1 hom Verified 0.582688591468321 0.280051477322805 no 1391 0.255236557312832 862 NA FT PROTEOLYSIS NUCLEUS Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family; protein abundance increases in response to DNA replication stress protein deubiquitination|regulation of transcription, DNA-dependent ubiquitin-specific protease activity nucleus|cytoplasm
YER078C YER078C ICP55 hom Verified 0.582591948370748 0.280084013460831 no 1392 0.280218357026158 967 NA FT PROTEOLYSIS NUCLEUS|MITOCHONDRION Mitochondrial aminopeptidase; cleaves the N termini of at least 38 imported proteins after cleavage by the mitochondrial processing peptidase (MPP), thereby increasing their stability; member of the aminopeptidase P family protein stabilization|protein processing aminopeptidase activity extrinsic to mitochondrial inner membrane|mitochondrion|nucleus
YPL110C YPL110C GDE1 hom Verified 0.580439491506524 0.28080914006715 no 1393 0.288947412854627 1008 NA FT LIPID METABOLISM|SIGNALING|CARBOHYDRATE METABOLISM Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes glycerophospholipid catabolic process glycerophosphocholine phosphodiesterase activity ribosome|cytoplasm
YJL190C YJL190C RPS22A hom Verified 0.579681403820724 0.281064743064425 no 1394 0.282124395889232 976 NA FT TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22A has a paralog, RPS22B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic small ribosomal subunit
YMR069W YMR069W NAT4 hom Verified 0.579511628807907 0.281122001187013 no 1395 0.30204114890587 1032 NA FT CHROMATIN ORGANIZATION NUCLEUS N alpha-acetyl-transferase, involved in acetylation of the N-terminal residues of histones H4 and H2A histone acetylation histone acetyltransferase activity nucleus|cytoplasm
YAL065C_p YAL065C YAL065C hom Uncharacterized 0.579347404498258 0.281177392646375 no 1396 0.267920536780053 916 NA Putative protein of unknown function; has homology to FLO1; possible pseudogene biological_process molecular_function cellular_component
YGL216W YGL216W KIP3 hom Verified 0.579077805813073 0.28126833741153 no 1397 0.251312005449858 875 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CYTOSKELETON ORGANIZATION NUCLEUS|CYTOSKELETON Kinesin-related motor protein involved in mitotic spindle positioning nuclear migration along microtubule|mitotic spindle disassembly|establishment of mitotic spindle orientation|plus-end specific microtubule depolymerization|mitotic spindle organization in nucleus plus-end-directed microtubule motor activity|tubulin-dependent ATPase activity kinesin complex|cytoplasmic microtubule|nuclear microtubule
YBR063C_p YBR063C YBR063C hom Uncharacterized 0.57824509499452 0.28154932860694 no 1398 0.26827733394581 941 NA Putative protein of unknown function; YBR063C is not an essential gene biological_process molecular_function cellular_component
YLR120C YLR120C YPS1 hom Verified 0.577971330580461 0.281641737650299 no 1399 0.298993809034837 1021 NA FT CELL WALL ORG/BIOGENESIS|PROTEOLYSIS PLASMA MEMBRANE Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor fungal-type cell wall organization|protein processing aspartic-type endopeptidase activity fungal-type cell wall
YML072C YML072C TCB3 hom Verified 0.577830894669776 0.28168914739781 no 1400 0.287478178137782 983 NA FT ENDOPLASMIC RETICULUM|MITOCHONDRION|PLASMA MEMBRANE Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact biological_process lipid binding mitochondrion|cortical endoplasmic reticulum|cellular bud
YER039C YER039C HVG1 hom Verified 0.57737448725138 0.281843252507295 no 1401 0.282789679649426 980 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Protein of unknown function, has homology to Vrg4p biological_process molecular_function integral to membrane
YCR049C_d YCR049C YCR049C hom Dubious 0.576043531548286 0.282292879041273 no 1402 0.304454322396543 1037 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR117C YDR117C TMA64 hom Verified 0.575881957545381 0.282347485828573 no 1403 0.260765243415075 875 NA FT TRANSLATION Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; in mammals the corresponding protein, eIF2D, has been shown to possess translation initiation factor activity biological_process RNA binding ribosome
YMR242C YMR242C RPL20A hom Verified 0.575805105572212 0.28237346109322 no 1404 0.271890007033173 951 NA FF|FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L20A; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20A has a paralog, RPL20B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YPR005C YPR005C HAL1 hom Verified 0.574347601998458 0.282866301484364 no 1405 0.278574054493304 957 NA FT TRANSCRIPTION FROM RNA POL II Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p response to salt stress|positive regulation of transcription from RNA polymerase II promoter molecular_function cytoplasm
YLR077W YLR077W FMP25 hom Verified 0.574288178131951 0.282886403837628 no 1406 0.289941982345913 998 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial inner membrane protein required for an early step in assembly of respiratory complex III (cytochrome bc1 complex); mRNA is targeted to mitochondria mitochondrial respiratory chain complex III assembly molecular_function mitochondrion|integral to mitochondrial inner membrane
YDR455C_d YDR455C YDR455C hom Dubious 0.573510212368961 0.283149643221623 no 1407 0.322001719368572 1110 NA FF Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W Unknown Unknown Unknown
YHR057C YHR057C CPR2 hom Verified 0.572623199681158 0.283449924012465 no 1408 0.271001028729012 908 NA Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway biological_process peptidyl-prolyl cis-trans isomerase activity cellular_component
YKR044W YKR044W UIP5 hom Verified 0.572436707555537 0.283513076687522 no 1409 0.274964005978604 937 NA FT ENDOMEMBRANE SYSTEM|NUCLEUS Protein of unknown function that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates biological_process molecular_function nuclear envelope
YKR105C_p YKR105C VBA5 hom Uncharacterized 0.570938925403269 0.284020521850532 no 1410 0.278856983129074 961 NA Plasma membrane protein of the Major Facilitator Superfamily (MFS); involved in amino acid uptake and drug sensitivity; similar to Vba3p biological_process molecular_function integral to membrane
YJR050W YJR050W ISY1 hom Verified 0.57054658099371 0.284153519022842 no 1411 0.30226047497074 1010 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING NUCLEUS Member of NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of spliceosome containing U2, U5, and U6 snRNAs, interacts with Prp16p to modulate splicing fidelity; isy1 syf2 cells have defective spindles generation of catalytic spliceosome for second transesterification step|mRNA 3'-splice site recognition first spliceosomal transesterification activity|second spliceosomal transesterification activity post-spliceosomal complex|Prp19 complex|post-mRNA release spliceosomal complex|U2-type catalytic step 2 spliceosome|U2-type catalytic step 1 spliceosome
YOR035C YOR035C SHE4 hom Verified 0.570214509468205 0.284266108117923 no 1412 0.372871735368799 1246 NA FF|FT CYTOSKELETON ORGANIZATION|RNA LOCALIZATION Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization mating type switching|intracellular mRNA localization|actin cytoskeleton organization myosin binding cytoplasm
YOR225W_d YOR225W YOR225W hom Dubious 0.570208851261997 0.284268026721666 no 1413 0.289775548316254 1012 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YMR237W YMR237W BCH1 hom Verified 0.566041127847202 0.285682911243574 no 1414 0.292714173871268 987 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM GOLGI APPARATUS Member of the ChAPs family (Chs5p-Arf1p-binding proteins); members include Bch1p, Bch2p, Bud7p, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p to mediate export of specific cargo proteins from the Golgi to the plasma membrane; may interact with ribosomes; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress; BCH1 has a paralog, BUD7, that arose from the whole genome duplication Golgi to plasma membrane transport|fungal-type cell wall chitin biosynthetic process molecular_function ribosome|clathrin-coated vesicle|exomer complex
YOR009W YOR009W TIR4 hom Verified 0.565389550398835 0.285904415276976 no 1415 0.281276853444278 964 NA FT CELL WALL ORG/BIOGENESIS Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth; transcription is also induced by cold shock biological_process molecular_function fungal-type cell wall
YGR174C YGR174C CBP4 hom Verified 0.563340873947115 0.286601395148475 no 1416 0.281833582067337 953 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial protein required for assembly of cytochrome bc1 complex; interacts with the Cbp3p-Cbp6p complex and newly synthesized cytochrome b (Cobp) to promote assembly of Cobp into the cytochrome bc1 complex mitochondrial respiratory chain complex III assembly molecular_function mitochondrion|integral to mitochondrial membrane
YBR018C YBR018C GAL7 hom Verified 0.561862365260696 0.287104898479454 no 1417 0.288052701990392 996 NA FT CARBOHYDRATE METABOLISM Galactose-1-phosphate uridyl transferase, synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism galactose catabolic process via UDP-galactose UDP-glucose:hexose-1-phosphate uridylyltransferase activity cytoplasm
YGR109C YGR109C CLB6 hom Verified 0.561685017335769 0.287165322100565 no 1418 0.279610100745624 952 NA FT CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION NUCLEUS B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 regulation of cyclin-dependent protein kinase activity|G1/S transition of mitotic cell cycle|regulation of S phase of mitotic cell cycle|premeiotic DNA replication cyclin-dependent protein kinase regulator activity cellular_component
YKR029C YKR029C SET3 hom Verified 0.561670934281093 0.287170120549231 no 1419 0.291253334072278 992 NA FT CELL CYCLE|CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Defining member of the SET3 histone deacetylase complex which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains; SET3 has a paralog, SET4, that arose from the whole genome duplication negative regulation of meiosis|regulation of transcription, DNA-dependent|histone deacetylation methylated histone residue binding Rpd3L-Expanded complex|Set3 complex
YLR118C YLR118C YLR118C hom Verified 0.560286137288655 0.287642140751107 no 1420 0.270850436781803 915 NA FT KETONE METABOLISM|LIPID METABOLISM NUCLEUS Acyl-protein thioesterase responsible for depalmitoylation of Gpa1p; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS protein deacylation palmitoyl-(protein) hydrolase activity nucleus|cytoplasm
YDL159W-A_p YDL159W-A YDL159W-A hom Uncharacterized 0.56022571198003 0.287662745594211 no 1421 0.281139608426451 960 NA Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species biological_process molecular_function cellular_component
YJL070C_p YJL070C YJL070C hom Uncharacterized 0.558242479539572 0.288339408554167 no 1422 0.241284106620763 830 NA FT NUCLEOTIDE METABOLISM MITOCHONDRION Putative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic defect of quadruple aah1 ade8 amd1 his1 mutant; may regulate purine nucleotide homeostasis as overexpression in an AMD1 strain grown in adenine results in greatly reduced GDP and GTP intracellular levels; not an essential gene; YJL070C has a paralog, YBR284W, that arose from the whole genome duplication biological_process AMP deaminase activity|molecular_function mitochondrion|cytoplasm
YBR059C YBR059C AKL1 hom Verified 0.55804592938047 0.288406510742103 no 1423 0.292042367170621 989 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION SITE OF POLARIZED GROWTH Ser-Thr protein kinase, member (with Ark1p and Prk1p) of the Ark kinase family; involved in endocytosis and actin cytoskeleton organization regulation of endocytosis|protein phosphorylation|actin cytoskeleton organization protein kinase activity cellular bud neck|cytoplasm
YCL026C-B YCL026C-B HBN1 hom Verified 0.557747690163286 0.288508343612689 no 1424 0.299111741461491 1029 NA FT OXIDATION-REDUCTION PROCESS NUCLEUS Protein of unknown function; similar to bacterial nitroreductases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein becomes insoluble upon intracellular iron depletion; protein abundance increases in response to DNA replication stress biological_process NAD(P)H nitroreductase activity nucleus|cytoplasm
YGL191W YGL191W COX13 hom Verified 0.557096593464643 0.288730717446634 no 1425 0.267310483152746 922 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Subunit VIa of cytochrome c oxidase; present in a subclass of cytochrome c oxidase complexes that may have a role in mimimizing generation of reactive oxygen species; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; required for assembly of Rcf2p into cytochrome c oxidase - cytochrome bc1 supercomplexes mitochondrial respiratory chain supercomplex assembly|aerobic respiration enzyme regulator activity|cytochrome-c oxidase activity mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YNL219C YNL219C ALG9 hom Verified 0.556274400688015 0.289011642231794 no 1426 0.30131512291298 1009 NA FT LIPID METABOLISM|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Mannosyltransferase, involved in N-linked glycosylation; catalyzes both the transfer of seventh mannose residue on B-arm and ninth mannose residue on the C-arm from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation dolichol-linked oligosaccharide biosynthetic process|protein glycosylation mannosyltransferase activity integral to membrane|endoplasmic reticulum
YLR036C_p YLR036C YLR036C hom Uncharacterized 0.555886983908244 0.289144058387519 no 1427 0.275839283577693 966 NA Putative protein of unknown function predicted to have transmembrane domains; interacts with HSP90 by yeast two-hybrid analysis; YLR036C is not an essential protein biological_process molecular_function integral to membrane
YOR325W_d YOR325W YOR325W hom Dubious 0.553376738638777 0.290002731906331 no 1428 0.293071714868002 1019 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF FRT1 Unknown Unknown Unknown
YAL031C YAL031C GIP4 hom Verified 0.55298899927459 0.290135471490005 no 1429 0.279796758463723 951 NA FT CHROMOSOME SEGREGATION Cytoplasmic Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; potential Cdc28p substrate chromosome segregation|regulation of phosphoprotein phosphatase activity protein phosphatase 1 binding|protein phosphatase type 1 regulator activity cytoplasm
YDR066C YDR066C RTR2 hom Verified 0.552530829559421 0.290292359050227 no 1430 0.293920007894592 995 NA FT NUCLEUS Protein of unknown function; exhibits genetic interactions with Rtr1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDR066C is not an essential gene; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; RTR2 has a paralog, RTR1, that arose from the whole genome duplication biological_process molecular_function cytoplasm
YHR018C YHR018C ARG4 hom Verified 0.552480830131957 0.290309482377046 no 1431 0.284144011550146 969 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway arginine biosynthetic process via ornithine argininosuccinate lyase activity cytosol
YIL136W YIL136W OM45 hom Verified 0.551749503510168 0.29055999418265 no 1432 0.29567989209536 976 NA FT MITOCHONDRION Mitochondrial outer membrane protein of unknown function; major constituent of the outer membrane, located on the outer (cytosolic) face; protein abundance increases in response to DNA replication stress biological_process molecular_function mitochondrial outer membrane|mitochondrion|integral to mitochondrial outer membrane
YPL154C YPL154C PEP4 hom Verified 0.550560375495846 0.29096753907771 no 1433 0.300008879622878 1023 NA FT MEMBRANE ORGANIZATION|PROTEOLYSIS|RESPONSE TO NUTRIENT LEVELS MITOCHONDRION Vacuolar aspartyl protease (proteinase A), required for the posttranslational precursor maturation of vacuolar proteinases; important for protein turnover after oxidative damage; synthesized as a zymogen, self-activates microautophagy|proteolysis involved in cellular protein catabolic process|cellular response to starvation peptidase activity fungal-type vacuole lumen|mitochondrion|fungal-type vacuole
YNL316C YNL316C PHA2 hom Verified 0.550224753471054 0.291082613730971 no 1434 0.270015732962934 939 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Prephenate dehydratase, catalyzes the conversion of prephanate to phenylpyruvate, which is a step in the phenylalanine biosynthesis pathway L-phenylalanine biosynthetic process prephenate dehydratase activity cytoplasm
YGL186C YGL186C TPN1 hom Verified 0.548604702848644 0.29163837887091 no 1435 0.389007959500273 1297 NA FF|FT PLASMA MEMBRANE Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p vitamin transport vitamin transporter activity integral to membrane|plasma membrane
YLR304C YLR304C ACO1 hom Verified 0.548405623447917 0.291706708006105 no 1436 0.353193389651366 1182 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy propionate metabolic process|glutamate biosynthetic process|tricarboxylic acid cycle|mitochondrial genome maintenance|citrate metabolic process double-stranded DNA binding|aconitate hydratase activity|single-stranded DNA binding mitochondrial nucleoid|cytosol|mitochondrion|mitochondrial matrix
YKL025C YKL025C PAN3 hom Verified 0.548063892690649 0.291824016123583 no 1437 0.322615348323166 1091 NA FT RNA PROCESSING|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes DNA repair|mRNA 3'-end processing|postreplication repair poly(A)-specific ribonuclease activity PAN complex|cytoplasm
YML109W YML109W ZDS2 hom Verified 0.547784213604287 0.2919200397151 no 1438 0.262229713490947 879 NA FT PROTEIN LOCALIZATION|CELL CYCLE|GENE SILENCING NUCLEUS|SITE OF POLARIZED GROWTH Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintenance of Cdc55p in the cytoplasm where it promotes mitotic entry; interacts with silencing proteins at the telomere; implicated in the mitotic exit network through regulation of Cdc14p localization; ZDS2 has a paralog, ZDS1, that arose from the whole genome duplication positive regulation of G2/M transition of mitotic cell cycle|cell shape checkpoint|establishment of cell polarity|regulation of protein localization|chromatin silencing at rDNA|cell aging molecular_function nucleus|cellular bud neck|cellular bud tip|cytoplasm
YDL133W YDL133W SRF1 hom Verified 0.544499403252335 0.293048929470736 no 1439 0.351932141500761 1176 NA Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients positive regulation of catalytic activity molecular_function integral to membrane
YHL007C YHL007C STE20 hom Verified 0.543391465847715 0.293430150175339 no 1440 0.300423151800473 1046 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|SIGNALING|CELL DIVISION|PROTEIN PHOSPHORYLATION NUCLEUS|SITE OF POLARIZED GROWTH Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p negative regulation of gene expression|osmosensory signaling pathway via Sho1 osmosensor|activation of MAPKKK activity|vacuole inheritance|protein phosphorylation|cellular bud site selection|cellular response to heat|regulation of exit from mitosis|pheromone-dependent signal transduction involved in conjugation with cellular fusion|signal transduction involved in filamentous growth|pseudohyphal growth|sterol import|stress granule assembly|invasive growth in response to glucose limitation|positive regulation of apoptotic process histone serine kinase activity|MAP kinase kinase kinase kinase activity|protein kinase activity incipient cellular bud site|plasma membrane|nucleus|mating projection tip
YHR043C YHR043C DOG2 hom Verified 0.542493147387476 0.293739413441172 no 1441 0.287129268229694 987 NA FT CARBOHYDRATE METABOLISM NUCLEUS 2-deoxyglucose-6-phosphate phosphatase; member of a family of low molecular weight phosphatases, paralogous to DOG1, induced by oxidative and osmotic stress, confers 2-deoxyglucose resistance when overexpressed glucose metabolic process 2-deoxyglucose-6-phosphatase activity nucleus|cytoplasm
YHR183W YHR183W GND1 hom Verified 0.542143834201093 0.293859711885641 no 1442 0.284881417285841 962 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS MITOCHONDRION 6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress; GND1 has a paralog, GND2, that arose from the whole genome duplication cellular response to oxidative stress|pentose-phosphate shunt, oxidative branch phosphogluconate dehydrogenase (decarboxylating) activity mitochondrion|cytoplasm
YLR035C YLR035C MLH2 hom Verified 0.540668523416168 0.294368038928547 no 1443 0.302200376186836 1025 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS Protein involved in the mismatch repair of certain frameshift intermediates and involved in meiotic recombination; forms a complex with Mlh1p mismatch repair|reciprocal meiotic recombination molecular_function nucleus
YAR027W YAR027W UIP3 hom Verified 0.540642396298708 0.294377044838846 no 1444 0.291065959369062 987 NA FT ENDOMEMBRANE SYSTEM|NUCLEUS|PLASMA MEMBRANE Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family biological_process molecular_function nuclear envelope
YIL170W YIL170W HXT12 hom pseudogene 0.540561559014507 0.294404909925052 no 1445 0.287756405116531 999 NA Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family hexose transport|biological_process hexose transmembrane transporter activity|molecular_function integral to membrane
YLR416C_d YLR416C YLR416C hom Dubious 0.540423939936297 0.294452350829794 no 1446 0.286406651020103 974 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YBL103C YBL103C RTG3 hom Verified 0.538863429299307 0.294990546460433 no 1447 0.288490638232013 985 NA FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|SIGNALING NUCLEUS Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways mitochondrion degradation|cellular response to oleic acid|mitochondria-nucleus signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription factor import into nucleus RNA polymerase II transcription factor binding|sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity nucleus|cytoplasm
YDR536W YDR536W STL1 hom Verified 0.538532755638256 0.295104648783538 no 1448 0.286375287971489 988 NA FT PLASMA MEMBRANE Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock transport|glycerol transport|transmembrane transport solute:hydrogen symporter activity|transporter activity integral to membrane|plasma membrane|membrane
YOR197W YOR197W MCA1 hom Verified 0.538523999978014 0.295107670289699 no 1449 0.280565603735135 941 NA FT PROTEOLYSIS NUCLEUS Ca2+-dependent cysteine protease; may cleave specific substrates during the stress response; regulates apoptosis upon H2O2 treatment; required for clearance of insoluble protein aggregates during normal growth; implicated in cell cycle dynamics; undergoes autocatalytic processing; similar to mammalian metacaspases, but exists as a monomer due to an extra pair of anti-parallel beta-strands that form a continuous beta-sheet, blocking potential dimerization misfolded or incompletely synthesized protein catabolic process|apoptotic process cysteine-type peptidase activity nucleus
YML118W YML118W NGL3 hom Verified 0.537476474643488 0.295469265413674 no 1450 0.266249487042172 907 NA 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication polyadenylation-dependent RNA catabolic process poly(A)-specific ribonuclease activity|endonuclease activity cellular_component
YCL028W YCL028W RNQ1 hom Verified 0.536584688675029 0.295777261377525 no 1451 0.277402288907186 975 NA FT NUCLEUS [PIN(+)] prion, an infectious protein conformation that is generally an ordered protein aggregate biological_process molecular_function cytosol
YIL014W YIL014W MNT3 hom Verified 0.53652634251594 0.295797417520158 no 1452 0.271606103054914 954 NA FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Alpha-1,3-mannosyltransferase, adds the fourth and fifth alpha-1,3-linked mannose residues to O-linked glycans during protein O-glycosylation protein O-linked glycosylation alpha-1,3-mannosyltransferase activity cellular_component
YLR282C_d YLR282C YLR282C hom Dubious 0.535909827305877 0.296010436130024 no 1453 0.282432561417756 957 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition Unknown Unknown Unknown
YMR023C YMR023C MSS1 hom Verified 0.535898533588096 0.296014338997152 no 1454 0.264469215533809 892 NA FT RNA PROCESSING|SIGNALING|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial protein, forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; similar to human GTPBP3 mitochondrial tRNA wobble uridine modification|Unknown GTP binding mitochondrion|mitochondrial inner membrane
YJR014W YJR014W TMA22 hom Verified 0.534202353810563 0.296600770401854 no 1455 0.241290682592514 797 NA FT TRANSLATION RIBOSOME Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1; protein abundance increases in response to DNA replication stress biological_process RNA binding ribosome|cytoplasm
YNL162W-A_p YNL162W-A YNL162W-A hom Uncharacterized 0.533333064293275 0.296901521706218 no 1456 0.287733420540884 971 NA FT NUCLEUS Putative protein of unknown function; identified by homology biological_process molecular_function nucleus|cytoplasm
YJL102W YJL102W MEF2 hom Verified 0.532318368579797 0.297252756128707 no 1457 0.312031916835504 1042 NA FT TRANSLATION|NUCLEOTIDE METABOLISM MITOCHONDRION Mitochondrial elongation factor involved in translational elongation translational elongation translation elongation factor activity mitochondrion
YPL183C YPL183C RTT10 hom Verified 0.531851864535749 0.297414299048377 no 1458 0.303633162836094 1027 NA FT VESICLE-MEDIATED TRANSPORT WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rrt2p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; evidence it interacts with Trm7p for 2'-O-methylation of N34 of substrate tRNAs; has a role in regulation of Ty1 transposition; human ortholog is WDR6 endocytic recycling molecular_function endosome|cytoplasm
YGR165W YGR165W MRPS35 hom Verified 0.529818200781519 0.298118992351729 no 1459 0.331103042347576 1096 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YGR064W_d YGR064W YGR064W hom Dubious 0.529667424061434 0.298171268897246 no 1460 0.381815121861514 1255 NA FF Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SPT4/YGR063C Unknown Unknown Unknown
YOR129C YOR129C AFI1 hom Verified 0.52889155742108 0.298440339473187 no 1461 0.287412174959761 984 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION NUCLEUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Arf3p polarization-specific docking factor, required for the polarized distribution of the ADP-ribosylation factor, Arf3p; participates in polarity development and maintenance of a normal haploid budding pattern; interacts with Cnm7p asymmetric protein localization|actin cortical patch localization|cellular bud site selection molecular_function nucleus|plasma membrane|cellular bud neck|cytoplasm
YPR199C YPR199C ARR1 hom Verified 0.528666150038824 0.298518531468459 no 1462 0.289424215574511 978 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Transcriptional activator of the basic leucine zipper (bZIP) family, required for transcription of genes involved in resistance to arsenic compounds positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus|cytoplasm
YDR452W YDR452W PPN1 hom Verified 0.527962684469791 0.298762617883638 no 1463 0.346380612718105 1135 NA FT NUCLEUS Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress polyphosphate catabolic process|polyphosphate metabolic process endopolyphosphatase activity|exopolyphosphatase activity fungal-type vacuole membrane|nucleus
YOL012C YOL012C HTZ1 hom Verified 0.527517576465304 0.29891710699197 no 1464 0.319313137177855 1077 NA FF|FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin nuclear-transcribed mRNA catabolic process, non-stop decay|regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette chromatin binding nuclear chromatin|chromatin assembly complex
YPL088W_p YPL088W YPL088W hom Uncharacterized 0.527413655412798 0.298953181374161 no 1465 0.296010068102978 998 NA FT OXIDATION-REDUCTION PROCESS Putative aryl alcohol dehydrogenase; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance cellular aldehyde metabolic process aryl-alcohol dehydrogenase (NAD+) activity cellular_component
YPR146C_d YPR146C YPR146C hom Dubious 0.526404713742691 0.299303520634703 no 1466 0.280724084932455 976 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YHR177W_p YHR177W YHR177W hom Uncharacterized 0.526066356546005 0.299421051581573 no 1467 0.302051751998889 1059 NA Putative protein of unknown function; overexpression causes a cell cycle delay or arrest biological_process molecular_function cellular_component
YBR300C_d YBR300C YBR300C hom Dubious 0.525837548876523 0.299500541525036 no 1468 0.301392994837783 1046 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR301W; YBR300C is not an essential gene Unknown Unknown Unknown
YJR097W YJR097W JJJ3 hom Verified 0.525703674704388 0.299547055111086 no 1469 0.307978652691198 1062 NA FT NUCLEUS Protein of unknown function, contains a CSL Zn finger and a DnaJ-domain; involved in diphthamide biosynthesis; ortholog human Dph4 peptidyl-diphthamide biosynthetic process from peptidyl-histidine ferrous iron binding nucleus|cytoplasm
YHR195W YHR195W NVJ1 hom Verified 0.522967273368866 0.300498513877887 no 1470 0.318131434230003 1098 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|NUCLEUS Nuclear envelope protein, anchored to the nuclear inner membrane, that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN) microautophagy|cellular protein localization protein binding nuclear envelope
YAR031W YAR031W PRM9 hom Verified 0.522831367005852 0.300545804677162 no 1471 0.301431158273883 1005 NA FT VESICLE-MEDIATED TRANSPORT ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Pheromone-regulated protein with 3 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; member of DUP240 gene family vesicle organization molecular_function integral to membrane|endoplasmic reticulum|plasma membrane
YER152C YER152C YER152C hom Verified 0.522381238020351 0.300702458271645 no 1472 0.276443246649491 923 NA FT NUCLEUS Protein with 2-aminoadipate transaminase activity; shares amino acid similarity with the aminotransferases Aro8p and Aro9p; YER152C is not an essential gene biological_process 2-aminoadipate transaminase activity nucleus|cytoplasm
YLR097C YLR097C HRT3 hom Verified 0.522242925354596 0.300750601155064 no 1473 0.268331934592726 883 NA FT PROTEOLYSIS UBIQUITIN LIGASE COMPLEX Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular response to methylmercury ubiquitin-protein ligase activity|protein binding, bridging SCF ubiquitin ligase complex
YDR195W YDR195W REF2 hom Verified 0.521084117680446 0.301154087199003 no 1474 0.324698943592111 1095 NA FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS RNA-binding protein involved in the cleavage step of mRNA 3'-end formation prior to polyadenylation, and in snoRNA maturation; part of holo-CPF subcomplex APT, which associates with 3'-ends of snoRNA- and mRNA-encoding genes mRNA 3'-end processing|termination of RNA polymerase II transcription, poly(A)-coupled|snoRNA 3'-end processing|Unknown chromatin binding|RNA binding mRNA cleavage and polyadenylation specificity factor complex|nucleus
YER020W YER020W GPA2 hom Verified 0.520762017478788 0.301266282793197 no 1475 0.279319116353334 956 NA FT SIGNALING|NUCLEOTIDE METABOLISM MITOCHONDRION|PLASMA MEMBRANE Nucleotide binding alpha subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p, has signaling role in response to nutrients; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery adenylate cyclase-activating G-protein coupled receptor signaling pathway|ascospore formation|replicative cell aging|signal transduction|glucose mediated signaling pathway|pseudohyphal growth|hexose mediated signaling|regulation of cell size GTPase activity mitochondrion|plasma membrane
YML083C YML083C YML083C hom Verified 0.520614516686465 0.301317667308986 no 1476 0.2830798339629 985 NA Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions biological_process molecular_function cellular_component
YLR436C YLR436C ECM30 hom Verified 0.520510888153724 0.301353770505495 no 1477 0.317882559634673 1090 NA FT CELL WALL ORG/BIOGENESIS Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants have abormal relative levels of mannose and glucose and have Gap1p sorting and transport defects; (GFP)-fusion protein localizes to the cytoplasm fungal-type cell wall organization molecular_function cytoplasm
YFL012W_p YFL012W YFL012W hom Uncharacterized 0.520393611840744 0.301394630808048 no 1478 0.320948755536806 1085 NA Putative protein of unknown function; transcribed during sporulation; null mutant exhibits increased resistance to rapamycin biological_process molecular_function cellular_component
YMR280C YMR280C CAT8 hom Verified 0.51923735471439 0.301797616400253 no 1479 0.262223325352475 930 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS NUCLEUS Zinc cluster transcriptional activator; necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements; relative distribution to the nucleus increases upon DNA replication stress positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source|positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter|positive regulation of glyoxylate cycle by positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YBL007C YBL007C SLA1 hom Verified 0.518579940146182 0.302026850369737 no 1480 0.345400768328166 1152 NA FF|FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION NUCLEUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton; interacts with proteins regulating actin dynamics and proteins required for endocytosis; found in the nucleus and cell cortex; has 3 SH3 domains fungal-type cell wall organization|endocytosis|actin cortical patch assembly ubiquitin binding|protein binding, bridging cell cortex|nucleus|mating projection tip|actin cortical patch
YLR182W YLR182W SWI6 hom Verified 0.516620505916981 0.302710549126294 no 1481 0.339931090563305 1131 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE NUCLEUS Transcription cofactor; forms complexes with Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; also binds Stb1p to regulate transcription at START; cell wall stress induces phosphorylation by Mpk1p, which regulates Swi6p localization; required for the unfolded protein response, independently of its known transcriptional coactivators positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription involved in G1/S phase of mitotic cell cycle|positive regulation of reciprocal meiotic recombination|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription coactivator activity SBF transcription complex|MBF transcription complex|nucleus|cytoplasm
YIL123W YIL123W SIM1 hom Verified 0.515135552444934 0.303229150254022 no 1482 0.299300052874466 1013 NA FT CELL WALL ORG/BIOGENESIS Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated fungal-type cell wall organization molecular_function fungal-type cell wall
YOR073W YOR073W SGO1 hom Verified 0.51429825501661 0.303521740764882 no 1483 0.314152068371624 1072 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME|CYTOSKELETON KINETOCHORE Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability positive regulation of maintenance of meiotic sister chromatid cohesion|meiotic sister chromatid segregation|meiotic sister chromatid separation|sister chromatid biorientation|maintenance of meiotic sister chromatid cohesion|mitotic cell cycle spindle assembly checkpoint|mitotic sister chromatid segregation molecular_function condensed nuclear chromosome kinetochore|nucleus|spindle pole body|condensed nuclear chromosome, centromeric region
YLR110C YLR110C CCW12 hom Verified 0.51423578211053 0.303543576746531 no 1484 0.358202574330679 1197 NA FF|FT CELL WALL ORG/BIOGENESIS SITE OF POLARIZED GROWTH Cell wall mannoprotein; plays a role in maintenance of newly synthesized areas of cell wall; localizes to periphery of small buds, septum region of larger buds, and shmoo tip; CCW12 has a paralog, YDR134C, that arose from the whole genome duplication conjugation with cellular fusion|agglutination involved in conjugation with cellular fusion|fungal-type cell wall organization molecular_function fungal-type cell wall|mating projection tip|cellular bud tip
YPL220W YPL220W RPL1A hom Verified 0.513766692266999 0.303707558824023 no 1485 0.29021889525277 1001 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L1A; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1A has a paralog, RPL1B, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YCR008W YCR008W SAT4 hom Verified 0.512786502268008 0.304050336284748 no 1486 0.296002806776661 1041 NA FT PROTEIN LOCALIZATION|CELL CYCLE|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; partially redundant with Hal5p; has similarity to Npr1p cellular cation homeostasis|protein phosphorylation|cellular protein localization|G1/S transition of mitotic cell cycle|protein dephosphorylation protein kinase activity cellular_component
YLR063W_p YLR063W YLR063W hom Uncharacterized 0.512602297310281 0.304114772945041 no 1487 0.295909635573328 993 NA Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene biological_process S-adenosylmethionine-dependent methyltransferase activity cytoplasm
YOR047C YOR047C STD1 hom Verified 0.512512683250289 0.304146123002608 no 1488 0.312754703770619 1057 NA FT TRANSCRIPTION FROM RNA POL II|SIGNALING|CARBOHYDRATE METABOLISM NUCLEUS|PLASMA MEMBRANE Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+] response to salt stress|signal transduction|nicotinamide riboside biosynthetic process|glucose metabolic process|nicotinic acid riboside biosynthetic process|regulation of transcription from RNA polymerase II promoter protein kinase activator activity plasma membrane|nucleus
YDR477W YDR477W SNF1 hom Verified 0.512464060538658 0.304163133489677 no 1489 0.301625071587207 991 NA FT KETONE METABOLISM|SIGNALING|TRANSLATION|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION AMP-activated serine/threonine protein kinase; found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; regulates filamentous growth in response to starvation negative regulation of translation|protein phosphorylation|replicative cell aging|signal transduction|biofilm formation|positive regulation of gluconeogenesis|pseudohyphal growth|cell adhesion|regulation of carbohydrate metabolic process|invasive growth in response to glucose limitation|cellular response to nitrogen starvation AMP-activated protein kinase activity|protein kinase activity mitochondrion|AMP-activated protein kinase complex|nucleus|nuclear envelope lumen|fungal-type vacuole|cytoplasm
YDR230W_d YDR230W YDR230W hom Dubious 0.512077865717482 0.304298257459574 no 1490 0.28205558258204 971 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20 Unknown Unknown Unknown
YBL043W YBL043W ECM13 hom Verified 0.511876975630977 0.304368556556385 no 1491 0.268711864179682 913 NA FT CELL WALL ORG/BIOGENESIS Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; ECM13 has a paralog, YJR115W, that arose from the whole genome duplication fungal-type cell wall organization molecular_function cellular_component
YDR034C YDR034C LYS14 hom Verified 0.508847558268565 0.305429540444171 no 1492 0.312130386909274 1051 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer Unknown|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YJL078C YJL078C PRY3 hom Verified 0.508101899075001 0.305690941757529 no 1493 0.2680160268801 912 NA Cell wall-associated protein involved in export of acetylated sterols; member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); role in mating efficiency; expression of full-length transcript is daughter cell-specific; in response to alpha factor, a short transcript starting at +452 is expressed and the long form is repressed by Ste12p biological_process molecular_function fungal-type cell wall
YPL091W YPL091W GLR1 hom Verified 0.50700502052659 0.306075647952868 no 1494 0.314273812470084 1072 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS NUCLEUS|MITOCHONDRION Cytosolic and mitochondrial glutathione oxidoreductase; converts oxidized glutathione to reduced glutathione; mitochondrial but not cytosolic form has a role in resistance to hyperoxia; protein abundance increases in response to DNA replication stress cellular response to oxidative stress|protein glutathionylation glutathione-disulfide reductase activity mitochondrion|nucleus|cytoplasm
YJR018W_d YJR018W YJR018W hom Dubious 0.503978395145884 0.307138279594777 no 1495 0.299302354983797 1051 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YKL043W YKL043W PHD1 hom Verified 0.502914912928989 0.30751204789155 no 1496 0.281303003942598 913 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Transcriptional activator that enhances pseudohyphal growth; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate; PHD1 has a paralog, SOK2, that arose from the whole genome duplication pseudohyphal growth|positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nucleus
YLR150W YLR150W STM1 hom Verified 0.500635308910632 0.308313904022974 no 1497 0.29947517679668 1021 NA FT SIGNALING|TRANSLATION NUCLEUS RIBOSOME Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery translational elongation|TOR signaling cascade|regulation of translational initiation in response to stress|telomere maintenance|anti-apoptosis triplex DNA binding|DNA binding|telomeric DNA binding cytosolic ribosome|polysome|cytoplasm
YGR292W YGR292W MAL12 hom Verified 0.499170471594427 0.308829647455592 no 1498 0.282111367515018 965 NA FT CARBOHYDRATE METABOLISM Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose sucrose catabolic process|maltose catabolic process sucrose alpha-glucosidase activity|maltose alpha-glucosidase activity plasma membrane
YDL151C_d YDL151C BUD30 hom Dubious 0.498536998106681 0.309052799215632 no 1499 0.323122450823009 1083 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 96% of ORF overlaps the verified gene RPC53; diploid mutant displays a weak budding pattern phenotype in a systematic assay Unknown Unknown Unknown
YGR237C_p YGR237C YGR237C hom Uncharacterized 0.497409899785544 0.309450012906794 no 1500 0.299782046162952 1003 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm biological_process molecular_function cytoplasm
YOL084W YOL084W PHM7 hom Verified 0.496623157530431 0.30972740983221 no 1501 0.269403016879908 914 NA FT PLASMA MEMBRANE Protein of unknown function; expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole; protein abundance increases in response to DNA replication stress biological_process molecular_function integral to membrane|fungal-type vacuole
YCL009C YCL009C ILV6 hom Verified 0.49646146105388 0.309784435718479 no 1502 0.300330334115285 992 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Regulatory subunit of acetolactate synthase, which catalyzes the first step of branched-chain amino acid biosynthesis; enhances activity of the Ilv2p catalytic subunit, localizes to mitochondria branched-chain amino acid biosynthetic process enzyme regulator activity|acetolactate synthase activity mitochondrial nucleoid|acetolactate synthase complex|mitochondrion
YBR081C YBR081C SPT7 hom Verified 0.496138697238023 0.309898279300051 no 1503 0.364714683720459 1221 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION NUCLEUS|MITOCHONDRION HISTONE ACETYLTRANSFERASE Subunit of the SAGA transcriptional regulatory complex, involved in proper assembly of the complex; also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex conjugation with cellular fusion|histone acetylation|protein complex assembly|chromatin modification structural molecule activity SLIK (SAGA-like) complex|mitochondrion|SAGA complex
YDL072C YDL072C YET3 hom Verified 0.495015606074875 0.310294552233685 no 1504 0.308102389583209 1062 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein; protein abundance increases in response to DNA replication stress biological_process molecular_function integral to membrane|endoplasmic reticulum
YER056C-A YER056C-A RPL34A hom Verified 0.493857724984314 0.310703331199532 no 1505 0.271835238072553 949 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L34A; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34A has a paralog, RPL34B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YMR135C YMR135C GID8 hom Verified 0.49379210611773 0.310726504324439 no 1506 0.312950288195253 1046 NA FT KETONE METABOLISM|CELL CYCLE|CARBOHYDRATE METABOLISM|PROTEOLYSIS NUCLEUS Subunit of GID Complex, binds strongly to central component Vid30p; GID Complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; recruits Rmd5p, Fyv10 and Vid28p to GID Complex; contains LisH, CTLH, and CRA domains that mediate binding to Vid30p (LisH) and Rmd5p and Vid28p (CTLH and CRA); dosage-dependent regulator of START negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|traversing start control point of mitotic cell cycle molecular_function nucleus|GID complex|cytoplasm
YLR377C YLR377C FBP1 hom Verified 0.490769264977518 0.311794825269434 no 1507 0.314925514802322 1059 NA FT CARBOHYDRATE METABOLISM Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism; undergoes either proteasome-mediated or autophagy-mediated degradation depending on growth conditions; interacts with Vid30p gluconeogenesis|reactive oxygen species metabolic process fructose 1,6-bisphosphate 1-phosphatase activity cytosol
YJR119C YJR119C JHD2 hom Verified 0.490763815280471 0.311796752715004 no 1508 0.279532679607852 956 NA FT CHROMATIN ORGANIZATION|OXIDATION-REDUCTION PROCESS NUCLEUS JmjC domain family histone demethylase specific for H3-K4 (histone H3 Lys4); removes methyl groups specifically added by Set1p methyltransferase; protein levels regulated by Not4p (E3 ubiquitin ligase) polyubiquitin-mediated degradation histone demethylation histone demethylase activity (H3-K4 specific) nucleus|cytoplasm
YBR176W YBR176W ECM31 hom Verified 0.489835032348113 0.312125319372206 no 1509 0.32258643024186 1062 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM MITOCHONDRION Ketopantoate hydroxymethyltransferase, required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate pantothenate biosynthetic process 3-methyl-2-oxobutanoate hydroxymethyltransferase activity mitochondrion
YHR096C YHR096C HXT5 hom Verified 0.489484012874202 0.31224953511835 no 1510 0.331101016869007 1104 NA FT PLASMA MEMBRANE Hexose transporter with moderate affinity for glucose; induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs; HXT5 has a paralog, HXT3, that arose from the whole genome duplication glucose transport|hexose transport mannose transmembrane transporter activity|fructose transmembrane transporter activity|glucose transmembrane transporter activity integral to membrane|plasma membrane
YMR275C YMR275C BUL1 hom Verified 0.488639367008897 0.312548518568471 no 1511 0.324684572254508 1131 NA FT MITOCHONDRION ORGANIZATION PLASMA MEMBRANE UBIQUITIN LIGASE COMPLEX Ubiquitin-binding component of the Rsp5p E3-ubiquitin ligase complex; disruption causes temperature-sensitive growth, overexpression causes missorting of amino acid permeases; BUL1 has a paralog, BUL2, that arose from the whole genome duplication mitochondrion inheritance|protein monoubiquitination|protein polyubiquitination ubiquitin-ubiquitin ligase activity ubiquitin ligase complex|plasma membrane
YHR179W YHR179W OYE2 hom Verified 0.487739233379053 0.312867279144167 no 1512 0.323474422314403 1089 NA FT OXIDATION-REDUCTION PROCESS NUCLEUS|MITOCHONDRION Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress apoptotic process NADPH dehydrogenase activity mitochondrion|nucleus|cytoplasm
YHL041W_d YHL041W YHL041W hom Dubious 0.487602516039566 0.312915706536176 no 1513 0.279616293545654 966 NA Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data Unknown Unknown Unknown
YHR115C YHR115C DMA1 hom Verified 0.486674446933722 0.313244528245481 no 1514 0.320471549979852 1098 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION Ubiquitin-protein ligase (E3); controls septin dynamics and the spindle position checkpoint (SPOC) along with functionally redundant ligase Dma2p by regulating the recruitment of Elm1p to the bud neck; regulates levels of the translation initiation factor eIF2 subunit Gcd11p, as well as abundance, localization, and ubiquitination of Cdk inhibitory kinase Swe1p; ubiquitinates cyclin Pcl1p; ortholog of human RNF8 protein, similar to human Chfr; contains FHA and RING finger establishment of mitotic spindle orientation|protein autoubiquitination|septin ring assembly|mitotic cell cycle spindle assembly checkpoint ubiquitin-protein ligase activity cytoplasm
YHR021W-A_p YHR021W-A ECM12 hom Uncharacterized 0.486431533913865 0.313330618653057 no 1515 0.306824601917425 1055 NA FT CELL WALL ORG/BIOGENESIS Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity fungal-type cell wall organization molecular_function cellular_component
YKR055W YKR055W RHO4 hom Verified 0.486003876039879 0.313482208901781 no 1516 0.306345667720663 1074 NA FT SIGNALING|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely to be involved in the establishment of cell polarity positive regulation of formin-nucleated actin cable assembly|maintenance of cell polarity|regulation of formin-nucleated actin cable assembly GTPase activity incipient cellular bud site|plasma membrane|cellular bud neck
YPL152W YPL152W RRD2 hom Verified 0.484673100643925 0.313954125250253 no 1517 0.295803492311033 1011 NA FT CELL CYCLE|CYTOSKELETON ORGANIZATION Peptidyl-prolyl cis/trans-isomerase; also activates the phosphotyrosyl phosphatase activity of protein phosphatase 2A (PP2A); regulates G1 phase progression, the osmoresponse, microtubule dynamics; subunit of the Tap42p-Pph21p-Rrd2p complex; protein abundance increases in response to DNA replication stress mitotic spindle organization in nucleus|response to osmotic stress peptidyl-prolyl cis-trans isomerase activity|protein phosphatase type 2A regulator activity protein phosphatase type 2A complex
YOR062C_p YOR062C YOR062C hom Uncharacterized 0.484344864406608 0.31407057042639 no 1518 0.294187310131777 1028 NA FT NUCLEUS Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS biological_process molecular_function nucleus|cytoplasm
YDR421W YDR421W ARO80 hom Verified 0.483750720026845 0.314281396326804 no 1519 0.284444551638888 975 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Zinc finger transcriptional activator of the Zn2Cys6 family; activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids aromatic amino acid family catabolic process|positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|nucleic acid binding transcription factor activity nucleus
YAR050W YAR050W FLO1 hom Verified 0.482691931816768 0.314657246407076 no 1520 0.331322071487629 1063 NA FT PLASMA MEMBRANE Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p cellular response to stress|flocculation via cell wall protein-carbohydrate interaction|flocculation mannose binding fungal-type cell wall
YJR140C YJR140C HIR3 hom Verified 0.480915680943162 0.315288213735136 no 1521 0.313676581202291 1031 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION NUCLEUS Subunit of the HIR complex; a nucleosome assembly complex involved in regulation of histone gene transcription; involved in position-dependent gene silencing and nucleosome reassembly; ortholog of human CABIN1 protein DNA replication-independent nucleosome assembly|regulation of transcription involved in G1/S phase of mitotic cell cycle|transcription elongation from RNA polymerase II promoter nucleosome binding|DNA binding|transcription corepressor activity HIR complex|nucleus
YPL021W YPL021W ECM23 hom Verified 0.480095378519498 0.315579787126292 no 1522 0.289600381292907 987 NA FT CELL WALL ORG/BIOGENESIS Non-essential protein of unconfirmed function; affects pre-rRNA processing, may act as a negative regulator of the transcription of genes involved in pseudohyphal growth; homologous to Srd1p pseudohyphal growth sequence-specific DNA binding cellular_component
YPL064C YPL064C CWC27 hom Verified 0.477450961446798 0.316520516307914 no 1523 0.332450747135164 1110 NA FT RNA PROCESSING NUCLEUS Component of a complex containing Cef1p; putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p; protein abundance increases in response to DNA replication stress biological_process molecular_function U2-type spliceosomal complex
YGL259W_p YGL259W YPS5 hom Uncharacterized 0.477394895158724 0.316540474303549 no 1524 0.306425923760882 1053 NA FT PROTEOLYSIS Protein with similarity to GPI-anchored aspartic proteases such as Yap1p and Yap3p biological_process aspartic-type endopeptidase activity cellular_component
YJR066W YJR066W TOR1 hom Verified 0.476159268680344 0.316980457534674 no 1525 0.298061567582574 1021 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RIBOSOME BIOGENESIS|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS|PLASMA MEMBRANE PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication regulation of cell cycle|G1 phase of mitotic cell cycle|transcription of nuclear large rRNA transcript from RNA polymerase I promoter|regulation of cell growth|response to DNA damage stimulus|mitochondria-nucleus signaling pathway|ribosome biogenesis|meiosis|signal transduction|TOR signaling cascade|fungal-type cell wall organization|negative regulation of autophagy protein binding|protein kinase activity TORC1 complex|fungal-type vacuole membrane|endosome membrane|extrinsic to internal side of plasma membrane|plasma membrane|nucleus|Golgi membrane|cytoplasm
YBL039C YBL039C URA7 hom Verified 0.475354362832699 0.31726720860344 no 1526 0.309406124028166 1044 NA FT KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM Major CTP synthase isozyme (see also URA8); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA7 has a paralog, URA8, that arose from the whole genome duplication pyrimidine nucleobase biosynthetic process|CTP biosynthetic process|phospholipid biosynthetic process CTP synthase activity cytosol
YNL283C YNL283C WSC2 hom Verified 0.474226633418856 0.317669151463408 no 1527 0.344195406016961 1186 NA FF|FT SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity and recovery from heat shock; secretory pathway Wsc2p is required for the arrest of secretion response fungal-type cell wall organization|response to heat|Rho protein signal transduction transmembrane signaling receptor activity site of polarized growth|cellular bud|mating projection tip|cytoplasm
YGL219C YGL219C MDM34 hom Verified 0.470397022781541 0.319035695425671 no 1528 0.357431386060534 1165 NA FT MITOCHONDRION ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION Mitochondrial component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth mitochondrion organization|phospholipid transport molecular_function mitochondrial outer membrane|ERMES complex|mitochondrion|cytoplasm
YNL065W YNL065W AQR1 hom Verified 0.470123261363389 0.31913347797747 no 1529 0.307522565385691 1050 NA FT PLASMA MEMBRANE Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids; AQR1 has a paralog, QDR1, that arose from the whole genome duplication; relocalizes from plasma membrane to cytoplasm upon DNA replication stress monocarboxylic acid transport|drug transmembrane transport|amino acid export monocarboxylic acid transmembrane transporter activity|drug transmembrane transporter activity integral to membrane|plasma membrane
YDR481C YDR481C PHO8 hom Verified 0.469818787686653 0.319242245166525 no 1530 0.346433322567963 1156 NA FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM Repressible vacuolar alkaline phosphatase; regulated by levels of Pi and by Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides; contributes to NAD+ metabolism by producing nicotinamide riboside from NMN nicotinamide nucleotide metabolic process|protein dephosphorylation nucleotide phosphatase activity|alkaline phosphatase activity fungal-type vacuole membrane
YGR133W YGR133W PEX4 hom Verified 0.469497665904223 0.319356976420798 no 1531 0.305327599412431 1003 NA FT PROTEIN LOCALIZATION|SIGNALING|PEROXISOME ORGANIZATION Peroxisomal ubiquitin conjugating enzyme required for peroxisomal matrix protein import and peroxisome biogenesis peroxisome organization|protein import into peroxisome matrix, receptor recycling|protein autoubiquitination|protein monoubiquitination|protein polyubiquitination ubiquitin-protein ligase activity peroxisome
YOR026W YOR026W BUB3 hom Verified 0.469042354041905 0.319519681118106 no 1532 0.318072061359724 1085 NA FT CELL CYCLE NUCLEUS|CHROMOSOME KINETOCHORE Kinetochore checkpoint WD40 repeat protein that localizes to kinetochores during prophase and metaphase, delays anaphase in the presence of unattached kinetochores; forms complexes with Mad1p-Bub1p and with Cdc20p, binds Mad2p and Mad3p mitotic cell cycle G2/M transition decatenation checkpoint|mitotic cell cycle spindle assembly checkpoint ubiquitin binding mitotic checkpoint complex|condensed nuclear chromosome kinetochore
YDR207C YDR207C UME6 hom Verified 0.467043588877669 0.320234346243017 no 1533 0.383849329802263 1259 NA FF|FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS NUCLEUS|CHROMOSOME Key transcriptional regulator of early meiotic genes, binds URS1 upstream regulatory sequence, couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms complex with Ime1p, and also with Sin3p-Rpd3p spore germination|positive regulation of transcription from RNA polymerase II promoter during meiosis|negative regulation of transcription from RNA polymerase II promoter during meiosis|lipid particle organization|nitrogen catabolite repression of transcription from RNA polymerase II promoter|pseudohyphal growth|negative regulation of transcription from RNA polymerase II promoter during mitosis|Unknown RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|repressing transcription factor binding|transcription factor binding transcription factor activity Rpd3L-Expanded complex|Rpd3L complex
YMR188C YMR188C MRPS17 hom Verified 0.465368012682909 0.320833968468591 no 1534 0.316199971904026 1054 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YLR441C YLR441C RPS1A hom Verified 0.464915445007049 0.320996004764348 no 1535 0.340453571533153 1148 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal protein 10 (rp10) of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1A has a paralog, RPS1B, that arose from the whole genome duplication cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit|90S preribosome
YGR018C_p YGR018C YGR018C hom Uncharacterized 0.464741965517974 0.321058126005438 no 1536 0.301591692735692 994 NA Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the uncharacterized ORF YGR017W biological_process molecular_function cellular_component
YJR096W YJR096W YJR096W hom Verified 0.464469773063998 0.321155605449434 no 1537 0.321038027212157 1115 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS NUCLEUS Putative xylose and arabinose reductase; member of the aldo-keto reductase (AKR) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS cellular response to oxidative stress|D-xylose catabolic process|arabinose catabolic process alditol:NADP+ 1-oxidoreductase activity|aldo-keto reductase (NADP) activity nucleus|cytoplasm
YOR150W YOR150W MRPL23 hom Verified 0.463679721156377 0.321438614084588 no 1538 0.358131369679884 1175 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YHR104W YHR104W GRE3 hom Verified 0.463452143331089 0.321520155173155 no 1539 0.320681964676856 1068 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS NUCLEUS Aldose reductase; involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress galactose catabolic process|cellular response to oxidative stress|arabinose catabolic process|D-xylose catabolic process|response to stress D-xylose:NADP reductase activity|mRNA binding|glucose 1-dehydrogenase (NADP+) activity|alditol:NADP+ 1-oxidoreductase activity nucleus|cytoplasm
YEL040W YEL040W UTR2 hom Verified 0.461435780661588 0.322242992813587 no 1540 0.313943536587792 1057 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM SITE OF POLARIZED GROWTH|CYTOSKELETON Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck cell wall chitin metabolic process|fungal-type cell wall organization transferase activity, transferring glycosyl groups cellular bud neck septin ring|fungal-type cell wall
YGR215W YGR215W RSM27 hom Verified 0.460978098912239 0.322407159059904 no 1541 0.326362026806917 1102 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YLR432W YLR432W IMD3 hom Verified 0.460929353641183 0.322424645583195 no 1542 0.353433529900225 1188 NA FT OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed GTP biosynthetic process IMP dehydrogenase activity plasma membrane|cytoplasm
YDR414C YDR414C ERD1 hom Verified 0.460829177740241 0.322460583189186 no 1543 0.337842741105846 1143 NA FT PROTEIN LOCALIZATION|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p) protein retention in ER lumen|protein glycosylation molecular_function integral to membrane|membrane
YNL093W YNL093W YPT53 hom Verified 0.460199640087135 0.322686464651667 no 1544 0.384244186238974 1266 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|VACUOLAR TRANSPORT PLASMA MEMBRANE Rab family GTPase; similar to Ypt51p and Ypt52p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; YPT53 has a paralog, VPS21, that arose from the whole genome duplication endocytosis|protein targeting to vacuole GTPase activity late endosome
YOR058C YOR058C ASE1 hom Verified 0.460057097005466 0.322737618958549 no 1545 0.294398811438888 1014 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION NUCLEUS|CYTOSKELETON Mitotic spindle midzone localized protein; microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate; relative distribution to microtubules decreases upon DNA replication stress cytokinesis, completion of separation|mitotic anaphase B|microtubule bundle formation|spindle pole body separation|spindle midzone assembly|mitotic spindle stabilization|mitotic spindle elongation microtubule binding spindle midzone|nuclear microtubule|spindle
YLR096W YLR096W KIN2 hom Verified 0.459691923480118 0.322868683755268 no 1546 0.326495811924767 1095 NA FT VESICLE-MEDIATED TRANSPORT|PROTEIN PHOSPHORYLATION PLASMA MEMBRANE Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin1p protein autophosphorylation|exocytosis|protein phosphorylation protein serine/threonine kinase activity|protein kinase activity plasma membrane
YOR029W_d YOR029W YOR029W hom Dubious 0.459606434468949 0.322899369881127 no 1547 0.281495966330643 947 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR199C YLR199C PBA1 hom Verified 0.458974036915153 0.323126405276152 no 1548 0.293311014542673 1005 NA FT PROTEIN COMPLEX ORG/BIOGENESIS Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly proteasome assembly molecular_function cytoplasm
YMR133W YMR133W REC114 hom Verified 0.457501587563966 0.323655280730223 no 1549 0.28711855341435 991 NA FT CELL CYCLE NUCLEUS|CHROMOSOME Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division meiotic DNA double-strand break formation|reciprocal meiotic recombination molecular_function condensed nuclear chromosome
YDR150W YDR150W NUM1 hom Verified 0.457124679820568 0.323790716060088 no 1550 0.353982196064491 1199 NA FT PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION MITOCHONDRION|SITE OF POLARIZED GROWTH Protein required for nuclear migration, localizes to the mother cell cortex and the bud tip; may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex mitochondrion inheritance|nuclear migration along microtubule|mitochondrial fission|microtubule cytoskeleton organization tubulin binding cell cortex|mitochondrion|cellular bud tip
YER129W YER129W SAK1 hom Verified 0.456391205833382 0.324054344232592 no 1551 0.335578834148791 1137 NA FT CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION Upstream serine/threonine kinase for the SNF1 complex; partially redundant with Elm1p and Tos3p; members of this family have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome protein phosphorylation|glucose metabolic process|DNA-dependent DNA replication protein serine/threonine kinase activity|protein kinase activity cytoplasm
YFR016C YFR016C YFR016C hom Verified 0.456108060005013 0.324156137265209 no 1552 0.291024067575155 991 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and bud; interacts with Spa2p; YFL016C is not an essential gene biological_process molecular_function cellular bud|cytoplasm
YOR306C YOR306C MCH5 hom Verified 0.455991821051645 0.324197929840845 no 1553 0.313180682219306 1048 NA FT PLASMA MEMBRANE Plasma membrane riboflavin transporter; facilitates the uptake of vitamin B2; required for FAD-dependent processes; sequence similarity to mammalian monocarboxylate permeases, however mutants are not deficient in monocarboxylate transport riboflavin transport monocarboxylic acid transmembrane transporter activity|riboflavin transporter activity integral to membrane|plasma membrane
YDR133C_d YDR133C YDR133C hom Dubious 0.455645909036911 0.32432231221632 no 1554 0.308306565988151 1051 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C Unknown Unknown Unknown
YPL013C YPL013C MRPS16 hom Verified 0.454057877240299 0.324893585057388 no 1555 0.341635783125172 1150 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YNL067W YNL067W RPL9B hom Verified 0.45231708768606 0.325520283815392 no 1556 0.275325874684069 924 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L9B; nearly identical to paralog Rpl9Ap; homologous to mammalian ribosomal protein L9 and bacterial L6 cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YMR017W YMR017W SPO20 hom Verified 0.452307855169099 0.325523608915847 no 1557 0.299465718521575 1024 NA FT PLASMA MEMBRANE Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog ascospore-type prospore assembly SNAP receptor activity SNARE complex|prospore membrane
YDR537C_d YDR537C YDR537C hom Dubious 0.451427040285586 0.325840899121045 no 1558 0.328899335909763 1084 NA Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W Unknown Unknown Unknown
YJL207C YJL207C LAA1 hom Verified 0.449863387866995 0.326404474159051 no 1559 0.329322494796357 1076 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene protein localization|retrograde transport, endosome to Golgi molecular_function AP-1 adaptor complex|ribosome|clathrin-coated vesicle
YPL184C YPL184C MRN1 hom Verified 0.447809945210762 0.327145182657134 no 1560 0.328501049120424 1141 NA FT TRANSLATION RNA-binding protein that may be involved in translational regulation; binds specific categories of mRNAs, including those that contain upstream open reading frames (uORFs) and internal ribosome entry sites (IRES); interacts genetically with chromatin remodelers and splicing factors, linking chromatin state, splicing and as a result mRNA maturation biological_process molecular_function cytoplasm
YLR270W YLR270W DCS1 hom Verified 0.447463640916983 0.327270167186415 no 1561 0.340135479711205 1165 NA FT NUCLEUS|MITOCHONDRION Non-essential hydrolase involved in mRNA decapping; activates Xrn1p; may function in a feedback mechanism to regulate deadenylation, contains pyrophosphatase activity and a HIT (histidine triad) motif; interacts with neutral trehalase Nth1p; required for growth on glycerol medium; protein abundance increases in response to DNA replication stress deadenylation-dependent decapping of nuclear-transcribed mRNA|positive regulation of nuclease activity|nuclear-transcribed mRNA catabolic process, deadenylation-independent decay hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|enzyme activator activity|m7G(5')pppN diphosphatase activity mitochondrion|nucleus|cytoplasmic mRNA processing body|cytoplasm
YGL041C_d YGL041C YGL041C hom Dubious 0.447273115380385 0.327338937933629 no 1562 0.336788555115356 1120 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YML088W YML088W UFO1 hom Verified 0.446820923407121 0.327502181400873 no 1563 0.321206823846863 1078 NA FT RESPONSE TO DNA DAMAGE|PROTEOLYSIS NUCLEUS UBIQUITIN LIGASE COMPLEX F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular response to methylmercury|response to DNA damage stimulus ubiquitin-protein ligase activity|protein binding, bridging SCF ubiquitin ligase complex|nucleus|cytoplasm
YJL013C YJL013C MAD3 hom Verified 0.44596131890836 0.327812593672971 no 1564 0.311998586974998 1073 NA FT CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION NUCLEUS Subunit of the spindle-assembly checkpoint complex, which delays anaphase onset in cells with defects in mitotic spindle assembly; pseudosubstrate inhibitor of APC(Cdc20), the anaphase promoting complex involved in securin (Pds1p) turnover distributive segregation|mitotic cell cycle spindle assembly checkpoint|mitotic cell cycle G2/M transition decatenation checkpoint molecular_function mitotic checkpoint complex
YHR046C YHR046C INM1 hom Verified 0.445875293795833 0.327843664805025 no 1565 0.338467686711503 1122 NA FT LIPID METABOLISM|CARBOHYDRATE METABOLISM NUCLEUS Inositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate inositol phosphate dephosphorylation inositol monophosphate 1-phosphatase activity nucleus|cytoplasm
YLR403W YLR403W SFP1 hom Verified 0.445429399186364 0.328004735130796 no 1566 0.316480513860019 1084 NA FT TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS NUCLEUS Regulates transcription of ribosomal protein and biogenesis genes; regulates response to nutrients and stress, G2/M transitions during mitotic cell cycle and DNA-damage response, and modulates cell size; regulated by TORC1 and Mrs6p; sequence of zinc finger, ChIP localization data, and protein-binding microarray (PBM) data, and computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p at others; can form the [ISP+] prion positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter|regulation of cell size|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription factor binding transcription factor activity nucleus|cytoplasm
YAL067C YAL067C SEO1 hom Verified 0.44411956390605 0.328478071325853 no 1567 0.318126188866329 1019 NA Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide transport transporter activity integral to membrane|membrane
YOR187W YOR187W TUF1 hom Verified 0.443025685765319 0.328873578006236 no 1568 0.402971872890034 1313 NA FT TRANSLATION|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial translation elongation factor Tu; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans mitochondrial translational elongation|mitochondrial translation GTPase activity|translation elongation factor activity mitochondrion|mitochondrial matrix
YLR217W_d YLR217W YLR217W hom Dubious 0.442687283229471 0.328995970941671 no 1569 0.33902312353052 1136 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CPR6 Unknown Unknown Unknown
YNR057C YNR057C BIO4 hom Verified 0.439964640011041 0.329981358845649 no 1570 0.348023518798128 1183 NA FT KETONE METABOLISM|COFACTOR METABOLISM Dethiobiotin synthetase, catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; expression appears to be repressed at low iron levels biotin biosynthetic process dethiobiotin synthase activity cytoplasm
YNL074C YNL074C MLF3 hom Verified 0.4399014563814 0.330004240515941 no 1571 0.322904473753319 1107 NA Serine-rich protein of unknown function, predicted to be palmitoylated; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide response to drug molecular_function cytoplasm
YMR279C YMR279C YMR279C hom Verified 0.438568380282548 0.330487156241534 no 1572 0.338889424301866 1131 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Putative boron transporter involved in boron efflux and resistance; overexpression mutant but not null mutant displays boron tolerance phenotype; identified as a heat-induced gene in a high-throughout screen; YMR279C is not an essential gene; YMR279C has a paralog, ATR1, that arose from the whole genome duplication borate transmembrane transport borate efflux transmembrane transporter activity integral to membrane
YHL038C YHL038C CBP2 hom Verified 0.434664856993838 0.331902855337396 no 1573 0.285958495494015 946 NA FT RNA PROCESSING MITOCHONDRION Required for splicing of the group I intron bI5 of the COB pre-mRNA; nuclear-encoded mitochondrial protein that binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene Group I intron splicing RNA binding mitochondrion
YLR264W YLR264W RPS28B hom Verified 0.431862415720458 0.332920706225799 no 1574 0.315936891895494 1067 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S28, no bacterial homolog; RPS28B has a paralog, RPS28A, that arose from the whole genome duplication cytoplasmic translation|rRNA export from nucleus structural constituent of ribosome cytosolic small ribosomal subunit
YDR520C_p YDR520C URC2 hom Uncharacterized 0.430512910468649 0.33341128866112 no 1575 0.36608825501732 1203 NA FT TRANSCRIPTION FROM RNA POL II|NUCLEOTIDE METABOLISM NUCLEUS Putative Zn(II)2Cys6 motif containing transcription factor; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; similar to S. kluyveri Urc2p involved in uracil catabolism uracil catabolic process sequence-specific DNA binding nucleus|cytoplasm
YIR033W YIR033W MGA2 hom Verified 0.429818345735401 0.333663893302175 no 1576 0.270963471640216 924 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|GENE SILENCING ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting positive regulation of transcription from RNA polymerase II promoter in response to hypoxia|cellular response to cold|positive regulation of unsaturated fatty acid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|mRNA stabilization|positive regulation of transcription from RNA polymerase II promoter in response to cobalt ion|positive regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette molecular_function integral to endoplasmic reticulum membrane|nucleus
YAL036C YAL036C RBG1 hom Verified 0.428934916201645 0.3339852947073 no 1577 0.335610803762457 1131 NA FT TRANSLATION RIBOSOME Member of the DRG family of GTP-binding proteins; associates with translating ribosomes; interacts with Tma46p, Ygr250cp, Gir2p and Yap1p via two-hybrid cytoplasmic translation GTP binding polysomal ribosome|polysome|cytoplasm
YGR034W YGR034W RPL26B hom Verified 0.428891841385816 0.334000968916418 no 1578 0.346559152665722 1163 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L26B; binds to 5.8S rRNA; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26B has a paralog, RPL26A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YGL222C YGL222C EDC1 hom Verified 0.428677335140498 0.33407902848284 no 1579 0.326900630172111 1092 NA FT RNA PROCESSING|TRANSLATION NUCLEUS RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress deadenylation-dependent decapping of nuclear-transcribed mRNA|positive regulation of translation in response to stress mRNA binding nucleus|cytoplasm
YBL071W-A YBL071W-A KTI11 hom Verified 0.428567625809974 0.33411895486329 no 1580 0.383450269376688 1290 NA FT RNA PROCESSING NUCLEUS Zn-ribbon protein that co-purifies with Dph1 and Dph2 in a complex required for synthesis of diphthamide on translation factor eEF2 and with Elongator subunits Iki3p, Elp2p, and Elp3p involved in modification of wobble nucleosides in tRNAs peptidyl-diphthamide biosynthetic process from peptidyl-histidine|tRNA wobble uridine modification electron carrier activity|iron ion binding|zinc ion binding nucleus|cytoplasm
YER174C YER174C GRX4 hom Verified 0.42694689329158 0.334709004544443 no 1581 0.335418090340558 1124 NA FT ION HOMEOSTASIS|CYTOSKELETON ORGANIZATION|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS NUCLEUS Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx3p and Grx5p; protects cells from oxidative damage; mutant has increased aneuploidy tolerance; transcription is regulated by Yap5 cellular iron ion homeostasis|cellular response to oxidative stress|actin cytoskeleton organization disulfide oxidoreductase activity nucleus
YDR249C_p YDR249C YDR249C hom Uncharacterized 0.426461589918907 0.334885765345107 no 1582 0.339328029517688 1118 NA Putative protein of unknown function biological_process molecular_function cellular_component
YGR068C YGR068C ART5 hom Verified 0.426363921731034 0.334921343201861 no 1583 0.339435426974969 1118 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION Protein proposed to regulate the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membrane ubiquitin-dependent endocytosis ubiquitin protein ligase binding cellular_component
YFR039C_p YFR039C YFR039C hom Uncharacterized 0.42613364387512 0.33500523300763 no 1584 0.313232206457836 1036 NA Putative protein of unknown function; may be involved in response to high salt and changes in carbon source; deletion mutant has decreased spore survival in Drosophila feces biological_process molecular_function cellular_component
YNR020C YNR020C ATP23 hom Verified 0.423900833944522 0.335819067972606 no 1585 0.34848462479844 1174 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Putative metalloprotease of the mitochondrial inner membrane, required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex; substrate of the Mia40p-Erv1p disulfide relay system, and folding is assisted by Mia40p protein processing|mitochondrial proton-transporting ATP synthase complex assembly metalloendopeptidase activity mitochondrial inner membrane|mitochondrial intermembrane space
YLL028W YLL028W TPO1 hom Verified 0.423846622574183 0.335838837024303 no 1586 0.292718641424697 968 NA FT PLASMA MEMBRANE Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane spermidine transport|putrescine transport|spermine transport spermidine transmembrane transporter activity|spermine transmembrane transporter activity fungal-type vacuole membrane|integral to membrane|cellular bud membrane|plasma membrane
YPL132W YPL132W COX11 hom Verified 0.423741784923733 0.335877069055231 no 1587 0.342274016485974 1113 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION RIBOSOME Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p protein complex assembly|aerobic respiration copper ion binding mitochondrial envelope|mitochondrion|mitochondrial ribosome|mitochondrial inner membrane
YHL011C YHL011C PRS3 hom Verified 0.422590241448602 0.336297123846363 no 1588 0.350130657015529 1183 NA FF|FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes fungal-type cell wall organization|5-phosphoribose 1-diphosphate biosynthetic process|regulation of cell size ribose phosphate diphosphokinase activity cytoplasm
YHR161C YHR161C YAP1801 hom Verified 0.422199660154172 0.33643964477297 no 1589 0.337511372845621 1137 NA FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1801 has a paralog, YAP1802, that arose from the whole genome duplication endocytosis clathrin binding actin cortical patch
YEL010W_d YEL010W YEL010W hom Dubious 0.421453821090176 0.336711862549025 no 1590 0.29791535278736 1027 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR305C YDR305C HNT2 hom Verified 0.419733916352684 0.337339922702229 no 1591 0.32414038842391 1082 NA FT NUCLEUS|MITOCHONDRION Dinucleoside triphosphate hydrolase; has similarity to the tumor suppressor FHIT and belongs to the histidine triad (HIT) superfamily of nucleotide-binding proteins nucleoside catabolic process hydrolase activity|nucleoside-triphosphatase activity mitochondrion|nucleus|cytoplasm
YEL048C YEL048C TCA17 hom Verified 0.41889159800726 0.337647678890663 no 1592 0.316610570876036 1089 NA FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS GOLGI APPARATUS Subunit of TRAPPII, a multimeric GEF involved in intra-Golgi and endosome-to-Golgi transport; promotes association of TRAPPII-specific subunits with the core complex; sedlin related; human Sedlin mutations cause SEDT, a skeletal disorder early endosome to Golgi transport|protein complex assembly molecular_function TRAPP complex|Golgi apparatus|clathrin-coated vesicle
YPR196W_p YPR196W YPR196W hom Uncharacterized 0.418862991901513 0.337658132554834 no 1593 0.328821437903086 1136 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Putative maltose-responsive transcription factor regulation of transcription, DNA-dependent sequence-specific DNA binding cellular_component
YGR066C_p YGR066C YGR066C hom Uncharacterized 0.417427845764571 0.338182745404283 no 1594 0.356827376001084 1176 NA Putative protein of unknown function biological_process molecular_function cellular_component
YLR048W YLR048W RPS0B hom Verified 0.417416007618546 0.338187074107312 no 1595 0.307497512171213 1035 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION RIBOSOME Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2 cytoplasmic translation|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA export from nucleus|ribosomal small subunit assembly|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit
YOR386W YOR386W PHR1 hom Verified 0.415293398325883 0.338963566698729 no 1596 0.358690740820287 1192 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION DNA photolyase involved in photoreactivation, repairs pyrimidine dimers in the presence of visible light; induced by DNA damage; regulated by transcriptional repressor Rph1p photoreactive repair mRNA binding|deoxyribodipyrimidine photo-lyase activity mitochondrion|nucleus
YDL081C YDL081C RPP1A hom Verified 0.415292919419866 0.338963741969428 no 1597 0.335007409353533 1121 NA FT TRANSLATION RIBOSOME Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component cytoplasmic translation|translational elongation structural constituent of ribosome cytosolic large ribosomal subunit
YDR334W YDR334W SWR1 hom Verified 0.414986635289051 0.339075843406483 no 1598 0.364481377695922 1187 NA FF|FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A chromatin remodeling|histone exchange structural molecule activity Swr1 complex|nucleus
YDR130C YDR130C FIN1 hom Verified 0.414720364923109 0.339173311195755 no 1599 0.347273780191708 1156 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME|CYTOSKELETON KINETOCHORE Spindle pole body-related intermediate filament protein; forms cell cycle-specific filaments between spindle pole bodies in dividing cells; localizes to poles and microtubules of spindle during anaphase and contributes to spindle stability; involved in Glc7p localization and regulation; relative distribution to the nucleus increases upon DNA replication stress intermediate filament cytoskeleton organization|mitotic cell cycle spindle checkpoint|mitotic spindle stabilization|mitotic sister chromatid segregation microtubule binding|structural constituent of cytoskeleton spindle microtubule|condensed nuclear chromosome kinetochore|intermediate filament|nucleus|spindle pole body|astral microtubule|spindle
YJR021C YJR021C REC107 hom Verified 0.414668869769027 0.339192162146719 no 1600 0.327221253265935 1129 NA FT CELL CYCLE NUCLEUS|CHROMOSOME Protein involved in early stages of meiotic recombination; involved in coordination between the initiation of recombination and the first division of meiosis; part of a complex (Rec107p-Mei4p-Rec114p) required for ds break formation reciprocal meiotic recombination molecular_function condensed nuclear chromosome
YAL056W YAL056W GPB2 hom Verified 0.414367821956828 0.339302375474459 no 1601 0.336801237174406 1127 NA FT TRANSCRIPTION FROM RNA POL II|SIGNALING MITOCHONDRION|PLASMA MEMBRANE Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; GPB2 has a paralog, GPB1, that arose from the whole genome duplication signal transduction|glucose mediated signaling pathway|pseudohyphal growth|ascospore formation|negative regulation of Ras protein signal transduction|invasive growth in response to glucose limitation|positive regulation of transcription from RNA polymerase II promoter cAMP-dependent protein kinase inhibitor activity|signal transducer activity|GTPase activating protein binding mitochondrion|plasma membrane|cytoplasm
YIL020C YIL020C HIS6 hom Verified 0.414020167256258 0.339429668647786 no 1602 0.332377244953455 1122 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Phosphoribosyl-5-amino-1-phosphoribosyl-4-imidazolecarboxiamide isomerase, catalyzes the fourth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts histidine biosynthetic process 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity intracellular
YMR284W YMR284W YKU70 hom Verified 0.412844663848104 0.339860212854389 no 1603 0.31859437862556 1087 NA FT CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair chromatin assembly or disassembly|chromatin silencing|double-strand break repair via nonhomologous end joining|telomere maintenance|double-strand break repair via break-induced replication|double-strand break repair via homologous recombination|chromatin silencing at silent mating-type cassette damaged DNA binding|RNA binding nuclear chromatin|nuclear telomeric heterochromatin|nuclear envelope|Ku70:Ku80 complex
YKL156W YKL156W RPS27A hom Verified 0.411305884575581 0.340424127594453 no 1604 0.350740138435287 1160 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27A has a paralog, RPS27B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress cytoplasmic translation|ribosomal small subunit assembly|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit|cytoplasm
YIL036W YIL036W CST6 hom Verified 0.41061286554601 0.340678214181979 no 1605 0.258272396409896 942 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS NUCLEUS Basic leucine zipper (bZIP) transcription factor, in ATF/CREB family; mediates transcriptional activation of NCE103 (encoding carbonic anhydrase) in response to low CO2 levels such as in the ambient air; proposed to be a regulator of oleate responsive genes; involved in utilization of non-optimal carbon sources and chromosome stability; CST6 has a paralog, ACA1, that arose from the whole genome duplication cellular response to carbon dioxide|positive regulation of transcription from RNA polymerase II promoter by oleic acid|cellular response to oleic acid|positive regulation of transcription from RNA polymerase II promoter|DNA metabolic process sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YPL186C YPL186C UIP4 hom Verified 0.40844649925973 0.341472950627134 no 1606 0.362539312151163 1216 NA FT ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION Protein that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope biological_process molecular_function mitochondrial outer membrane|nuclear envelope|endoplasmic reticulum
YDR237W YDR237W MRPL7 hom Verified 0.407735444008951 0.341733956383992 no 1607 0.350563398612137 1196 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YAL044C YAL044C GCV3 hom Verified 0.406714590846035 0.342108811395061 no 1608 0.36834243496309 1221 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5,10-methylene-THF glycine catabolic process|one-carbon metabolic process|protein lipoylation glycine dehydrogenase (decarboxylating) activity mitochondrion|glycine cleavage complex
YOR147W YOR147W MDM32 hom Verified 0.406128590062636 0.342324059927789 no 1609 0.33240572434038 1146 NA FT ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS MITOCHONDRION Mitochondrial inner membrane protein with similarity to Mdm31p, required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34 mitochondrion inheritance|cellular ion homeostasis|mitochondrion organization molecular_function mitochondrion|mitochondrial inner membrane
YLR412C-A_p YLR412C-A YLR412C-A hom Uncharacterized 0.405882483360551 0.342414474586395 no 1610 0.345095366679797 1143 NA Putative protein of unknown function biological_process molecular_function cellular_component
YLR047C YLR047C FRE8 hom Verified 0.404989943999953 0.342742451359302 no 1611 0.375616223781089 1240 NA FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p cellular metal ion homeostasis oxidoreductase activity, oxidizing metal ions integral to membrane|membrane
YGR180C YGR180C RNR4 hom Verified 0.404158895956195 0.343047938846596 no 1612 0.376728925849904 1234 NA FT OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM NUCLEUS Ribonucleotide-diphosphate reductase (RNR) small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits; relocalizes from nucleus to cytoplasm upon DNA replication stress cofactor biosynthetic process|deoxyribonucleotide biosynthetic process ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor ribonucleoside-diphosphate reductase complex|nucleus|cytoplasm
YER106W YER106W MAM1 hom Verified 0.402659017427931 0.343599543398352 no 1613 0.33629835953224 1157 NA FT CELL CYCLE|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME KINETOCHORE Monopolin, kinetochore associated protein involved in chromosome attachment to meiotic spindle meiotic chromosome segregation|meiotic sister chromatid cohesion involved in meiosis I molecular_function condensed nuclear chromosome kinetochore|monopolin complex
YDR451C YDR451C YHP1 hom Verified 0.40142204631412 0.344054710286583 no 1614 0.394846649665771 1322 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE NUCLEUS|CHROMOSOME Homeobox transcriptional repressor; binds Mcm1p and early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval; YHP1 has a paralog, YOX1, that arose from the whole genome duplication negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription involved in G1 phase of mitotic cell cycle RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription nuclear chromatin|nucleus
YGL118C_d YGL118C YGL118C hom Dubious 0.400982809071787 0.344216390347278 no 1615 0.345430881913506 1178 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGR108W YGR108W CLB1 hom Verified 0.398654081691015 0.345074053212385 no 1616 0.325352731837412 1107 NA FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION NUCLEUS B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome G2/M transition of mitotic cell cycle|meiotic G2/MI transition|regulation of cyclin-dependent protein kinase activity|mitotic spindle organization in nucleus|positive regulation of spindle pole body separation cyclin-dependent protein kinase regulator activity cyclin-dependent protein kinase holoenzyme complex|nucleus|cytoplasm
YIR014W_p YIR014W YIR014W hom Uncharacterized 0.398122221956873 0.345270047339302 no 1617 0.330142214902812 1109 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; YIR014W is a non-essential gene biological_process molecular_function fungal-type vacuole
YOL153C YOL153C YOL153C hom pseudogene 0.397857279241579 0.345367696120651 no 1618 0.320124911915614 1081 NA Hypothetical protein biological_process molecular_function cellular_component
YMR044W YMR044W IOC4 hom Verified 0.396748018408802 0.34577664325111 no 1619 0.360681009025896 1193 NA FT CHROMATIN ORGANIZATION NUCLEUS Member of a complex (Isw1b) with Isw1p and Ioc2p; interacts directly with H3K36me3 nucleosomes through its PWWP domain to recruit the Isw1b complex to open reading frames in a Set2p-dependent manner; Isw1b exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing chromatin remodeling nucleosome binding|ATPase activity|DNA binding ISW1 complex
YIL017C YIL017C VID28 hom Verified 0.395406796133605 0.346271347135487 no 1620 0.339511789264818 1139 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS NUCLEUS GID Complex subunit, serves as adaptor for regulatory subunit Vid24p; protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); localized to the nucleus and the cytoplasm negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|vacuolar protein catabolic process|ascospore formation|positive regulation of transcription from RNA polymerase II promoter molecular_function nucleus|GID complex|cytoplasm
YMR161W YMR161W HLJ1 hom Verified 0.394950543196001 0.346439693863948 no 1621 0.35423522573115 1185 NA FT PROTEOLYSIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Co-chaperone for Hsp40p, anchored in the ER membrane; with its homolog Ydj1p promotes ER-associated protein degradation (ERAD) of integral membrane substrates; similar to E. coli DnaJ ER-associated protein catabolic process ATPase activator activity endoplasmic reticulum|endoplasmic reticulum membrane
YCR067C YCR067C SED4 hom Verified 0.394799131289374 0.34649556804404 no 1622 0.344924986560997 1126 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Integral endoplasmic reticulum membrane protein that stimulates Sar1p GTPase activity; involved in COPII vesicle budding through disassociation of coat proteins from membranes onto liposomes; binds Sec16p; similar to Sec12p positive regulation of GTPase activity|regulation of COPII vesicle coating Sar GTPase activator activity integral to endoplasmic reticulum membrane
YDL113C YDL113C ATG20 hom Verified 0.394204535778571 0.346715018603745 no 1623 0.335628356699699 1117 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Sorting nexin family member required for the cytoplasm-to-vacuole targeting (Cvt) pathway and for endosomal sorting; has a Phox homology domain that binds phosphatidylinositol-3-phosphate; interacts with Snx4p; potential Cdc28p substrate mitochondrion degradation|early endosome to Golgi transport|macroautophagy|CVT pathway phosphatidylinositol-3-phosphate binding endosome|pre-autophagosomal structure|extrinsic to membrane
YDL025C YDL025C RTK1 hom Verified 0.393850314548732 0.34684577739234 no 1624 0.380360983270866 1280 NA FT PROTEIN PHOSPHORYLATION Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance increases in response to DNA replication stress biological_process protein serine/threonine kinase activity|protein kinase activity cellular_component
YJL130C YJL130C URA2 hom Verified 0.393474354250777 0.346984580993448 no 1625 0.324451297190888 1053 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM MITOCHONDRION Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP glutamine metabolic process|'de novo' pyrimidine nucleobase biosynthetic process|negative regulation of pyrimidine nucleobase metabolic process aspartate carbamoyltransferase activity|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity mitochondrion|integral to membrane|cytoplasm
YNR071C_p YNR071C YNR071C hom Uncharacterized 0.393038366599924 0.347145572256509 no 1626 0.345230886240175 1151 NA FT CARBOHYDRATE METABOLISM Putative aldose 1-epimerase biological_process molecular_function cellular_component
YMR095C YMR095C SNO1 hom Verified 0.392109367240593 0.347488703279367 no 1627 0.324886300801152 1102 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Protein of unconfirmed function, involved in pyridoxine metabolism; expression is induced during stationary phase; forms a putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminase pyridoxine metabolic process|thiamine biosynthetic process|anti-apoptosis molecular_function cytoplasm
YCR033W YCR033W SNT1 hom Verified 0.389768565534949 0.348353845053805 no 1628 0.348703951928622 1165 NA FT CELL CYCLE|CHROMATIN ORGANIZATION|SIGNALING NUCLEUS|CHROMOSOME Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein; mutant has increased aneuploidy tolerance negative regulation of meiosis|regulation of transcription, DNA-dependent|histone deacetylation|positive regulation of stress-activated MAPK cascade molecular_function Rpd3L-Expanded complex|Set3 complex
YLR130C YLR130C ZRT2 hom Verified 0.388927955116672 0.348664720931137 no 1629 0.347865049232759 1148 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Low-affinity zinc transporter of the plasma membrane; transcription is induced under low-zinc conditions by the Zap1p transcription factor low-affinity zinc ion transport low-affinity zinc ion transmembrane transporter activity integral to membrane|plasma membrane
YOR178C YOR178C GAC1 hom Verified 0.388859278529443 0.348690123509721 no 1630 0.35191107239533 1182 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock meiosis|glycogen metabolic process|negative regulation of transcription from RNA polymerase II promoter|response to heat|mitotic cell cycle spindle assembly checkpoint protein phosphatase type 1 regulator activity|structural molecule activity|heat shock protein binding protein phosphatase type 1 complex
YDR370C YDR370C DXO1 hom Verified 0.38861015117962 0.348782278177422 no 1631 0.348174507038492 1162 NA Protein with decapping and 5′-3′ exoRNase activity; similar to Rai1p biological_process molecular_function cytoplasm
YNL231C YNL231C PDR16 hom Verified 0.386054903042301 0.349728003914528 no 1632 0.363747786468282 1211 NA FF|FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Phosphatidylinositol transfer protein (PITP); controlled by the multiple drug resistance regulator Pdr1p; localizes to lipid particles and microsomes; controls levels of various lipids, may regulate lipid synthesis; homologous to Pdr17p; protein abundance increases in response to DNA replication stress response to drug|sterol biosynthetic process|phospholipid biosynthetic process|phospholipid transport phosphatidylinositol transporter activity|phosphatidylcholine transporter activity cell periphery|lipid particle|plasma membrane|cytoplasm
YML128C YML128C MSC1 hom Verified 0.385619047882607 0.349889412082224 no 1633 0.35461075883896 1171 NA FT CELL CYCLE ENDOPLASMIC RETICULUM|MITOCHONDRION Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated reciprocal meiotic recombination molecular_function mitochondrion|endoplasmic reticulum|plasma membrane
YMR194C-A_d YMR194C-A YMR194C-A hom Dubious 0.385110924034125 0.350077617419345 no 1634 0.344508260738396 1153 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YMR105W-A_p YMR105W-A YMR105W-A hom Uncharacterized 0.384410363400986 0.350337160315454 no 1635 0.386772726235563 1285 NA Putative protein of unknown function biological_process molecular_function cellular_component
YJL162C YJL162C JJJ2 hom Verified 0.383758190171018 0.350578839533753 no 1636 0.339351953807371 1135 NA FT NUCLEUS Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein biological_process molecular_function nucleus|cytoplasm
YAL037W_p YAL037W YAL037W hom Uncharacterized 0.383501689307406 0.350673908969825 no 1637 0.359793933149585 1190 NA Putative protein of unknown function; YAL037W has a paralog, YOR342C, that arose from the whole genome duplication biological_process molecular_function cellular_component
YGR025W_d YGR025W YGR025W hom Dubious 0.382946188684135 0.350879831677556 no 1638 0.330203123346049 1116 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YHR011W YHR011W DIA4 hom Verified 0.382666181741181 0.350983646169533 no 1639 0.356545220195252 1216 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Probable mitochondrial seryl-tRNA synthetase, mutant displays increased invasive and pseudohyphal growth pseudohyphal growth|invasive growth in response to glucose limitation|mitochondrial seryl-tRNA aminoacylation serine-tRNA ligase activity mitochondrion|cytoplasm
YER182W_p YER182W FMP10 hom Uncharacterized 0.381967496604369 0.351242736964341 no 1640 0.349326898614922 1172 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YJL180C YJL180C ATP12 hom Verified 0.381189040287443 0.351531490450661 no 1641 0.348030871202807 1156 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Conserved protein required for assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase; mutation of human ATP12 reduces active ATP synthase levels and is associated with the disorder ATPAF2 deficiency mitochondrial proton-transporting ATP synthase complex assembly protein domain specific binding mitochondrion
YOR320C YOR320C GNT1 hom Verified 0.379268240144854 0.352244340825202 no 1642 0.35278523632532 1166 NA FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|GOLGI APPARATUS N-acetylglucosaminyltransferase capable of modification of N-linked glycans in the Golgi apparatus protein N-linked glycosylation acetylglucosaminyltransferase activity Golgi medial cisterna
YHR022C_p YHR022C YHR022C hom Uncharacterized 0.37830297141953 0.352602769146831 no 1643 0.333126017807099 1130 NA FT SIGNALING Putative protein of unknown function; YHR022C is not an essential gene biological_process molecular_function cellular_component
YGL199C_d YGL199C YGL199C hom Dubious 0.377907912073042 0.35274950229178 no 1644 0.330629528388312 1108 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YIP4/YGL198W Unknown Unknown Unknown
YKL092C YKL092C BUD2 hom Verified 0.37730673654345 0.352972833244153 no 1645 0.349678555796614 1160 NA FT CELL CYCLE|SIGNALING|CELL DIVISION|NUCLEOTIDE METABOLISM PLASMA MEMBRANE GTPase activating factor for Rsr1p/Bud1p; required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types; mutant deficient in mitotic spindle position checkpoint bipolar cellular bud site selection|small GTPase mediated signal transduction|filamentous growth|cellular bud site selection|axial cellular bud site selection GTPase activator activity|Ras GTPase activator activity intracellular
YPL176C YPL176C TRE1 hom Verified 0.377196361844831 0.353013841894522 no 1646 0.352729732436959 1189 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT PLASMA MEMBRANE Transferrin receptor-like protein; plasma membrane protein that binds Bsd2p and regulates ubiquitylation and vacuolar degradation of the metal transporter Smf1p; functionally redundant with Tre2p; TRE1 has a paralog, TRE2, that arose from the whole genome duplication protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway molecular_function fungal-type vacuole
YBL005W YBL005W PDR3 hom Verified 0.376714889709853 0.353192748165859 no 1647 0.344324516331081 1166 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Transcriptional activator of the pleiotropic drug resistance network; regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements); post-translationally up-regulated in cells lacking a functional mitochondrial genome; PDR3 has a paralog, PDR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress Unknown|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus|cytoplasm
YGL178W YGL178W MPT5 hom Verified 0.375016215286661 0.353824203608666 no 1648 0.338758811916401 1112 NA FT TRANSLATION mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity negative regulation of translation|negative regulation of translational initiation|Unknown mRNA binding|protein binding, bridging cytoplasm
YKL026C YKL026C GPX1 hom Verified 0.374879570877296 0.353875016521113 no 1649 0.358803960324538 1174 NA FT OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress cellular response to oxidative stress|peroxisome organization phospholipid-hydroperoxide glutathione peroxidase activity|glutathione peroxidase activity extrinsic to mitochondrial outer membrane|peroxisomal matrix
YJL193W_p YJL193W YJL193W hom Uncharacterized 0.374866497688497 0.353879878084386 no 1650 0.354494505059763 1156 NA Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect biological_process molecular_function integral to membrane
YNL177C YNL177C MRPL22 hom Verified 0.373734071389553 0.354301086957533 no 1651 0.367303967081435 1226 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YER098W YER098W UBP9 hom Verified 0.372609114634714 0.354719694059661 no 1652 0.365967473081802 1212 NA FT PROTEOLYSIS Ubiquitin-specific protease that cleaves ubiquitin-protein fusions; UBP9 has a paralog, UBP13, that arose from the whole genome duplication protein deubiquitination ubiquitin-specific protease activity cytoplasm
YGR087C YGR087C PDC6 hom Verified 0.372570031215477 0.354734240528729 no 1653 0.361370010935827 1200 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation L-phenylalanine catabolic process|ethanol metabolic process|tryptophan catabolic process|aromatic amino acid family catabolic process to alcohol via Ehrlich pathway pyruvate decarboxylase activity cytoplasm
YPL199C_p YPL199C YPL199C hom Uncharacterized 0.372294708448178 0.354836718989503 no 1654 0.355417027410059 1198 NA Putative protein of unknown function, predicted to be palmitoylated biological_process molecular_function cytoplasm
YCL032W YCL032W STE50 hom Verified 0.37118037441053 0.355251594811834 no 1655 0.359741508303743 1179 NA FT CELL CYCLE|SIGNALING Protein involved in mating response, invasive/filamentous growth, and osmotolerance, acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction pheromone-dependent signal transduction involved in conjugation with cellular fusion|MAPK cascade involved in osmosensory signaling pathway|osmosensory signaling pathway via Sho1 osmosensor|signal transduction involved in filamentous growth|cellular response to heat SAM domain binding|protein kinase regulator activity cytoplasm
YPL192C YPL192C PRM3 hom Verified 0.370870718873756 0.355366912634662 no 1656 0.345560389411884 1148 NA FT MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON Pheromone-regulated protein required for nuclear envelope fusion during karyogamy; localizes to the outer face of the nuclear membrane; interacts with Kar5p at the spindle pole body karyogamy involved in conjugation with cellular fusion|nuclear membrane fusion involved in karyogamy molecular_function nuclear envelope|spindle pole body|extrinsic to nuclear outer membrane
YGR010W YGR010W NMA2 hom Verified 0.370048324760949 0.355673242051936 no 1657 0.362968290249621 1203 NA FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM NUCLEUS Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in de novo and salvage synthesis of NAD(+); NMA2 has a paralog, NMA1, that arose from the whole genome duplication NAD biosynthetic process nicotinamide-nucleotide adenylyltransferase activity nucleus
YPL212C YPL212C PUS1 hom Verified 0.369762424552866 0.355779757422353 no 1658 0.340368816484719 1137 NA FT RNA PROCESSING NUCLEUS tRNA:pseudouridine synthase, introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA; nuclear protein that appears to be involved in tRNA export; also acts on U2 snRNA snRNA pseudouridine synthesis|tRNA pseudouridine synthesis pseudouridine synthase activity nucleus
YDR266C YDR266C HEL2 hom Verified 0.368550431189955 0.356231424281264 no 1659 0.363399630400483 1213 NA RING finger ubiquitin ligase (E3); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; computational analysis suggests a role as a transcription factor biological_process molecular_function ribosome|cytoplasm
YIL131C YIL131C FKH1 hom Verified 0.367474617536966 0.356632510878351 no 1660 0.357462160416584 1194 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RNA PROCESSING|CHROMATIN ORGANIZATION|MITOCHONDRION ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Forkhead family transcription factor; has a minor role in the expression of G2/M phase genes; negatively regulates transcriptional elongation; positive role in chromatin silencing at HML and HMR; binds to the recombination enhancer near HML, and regulates donor preference during mating-type switching by positioning HML near the MAT locus through FHA-domain mediated interactions with proteins near the DSB; FKH1 has a paralog, FKH2, that arose from the whole genome duplication mRNA 3'-end processing|termination of RNA polymerase II transcription|donor selection|negative regulation of transcription involved in G1 phase of mitotic cell cycle|positive regulation of transcription involved in G2/M-phase of mitotic cell cycle|cellular response to methylmercury|positive regulation of chromatin silencing at silent mating-type cassette|negative regulation of transcription elongation from RNA polymerase II promoter|Unknown|negative regulation of transcription involved in G2/M-phase of mitotic cell cycle|chromatin remodeling RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|centromeric DNA binding nucleus
YOR305W YOR305W RRG7 hom Verified 0.367260063129263 0.356712520383257 no 1661 0.334304398588325 1128 NA FT MITOCHONDRION Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YOR305W is not an essential gene biological_process molecular_function mitochondrion
YLR030W_p YLR030W YLR030W hom Uncharacterized 0.367105964227376 0.356769989310128 no 1662 0.333216896680045 1121 NA Putative protein of unknown function biological_process molecular_function cellular_component
YKL062W YKL062W MSN4 hom Verified 0.366586213056722 0.356963846859887 no 1663 0.359768208909097 1181 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|RESPONSE TO OXIDATIVE STRESS NUCLEUS Transcriptional activator; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression; MSN4 has a paralog, MSN2, that arose from the whole genome duplication positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription from RNA polymerase II promoter in response to a hypotonic environment|positive regulation of transcription from RNA polymerase II promoter in response to alkalinity|positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation|positive regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation|positive regulation of transcription from RNA polymerase II promoter in response to acidity|chromatin remodeling|regulation of replicative cell aging by regulation of transcription from RNA polymerase II promoter in response to caloric restriction|positive regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide|positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance|positive regulation of transcription from RNA polymerase II promoter in response to increased salt|cellular response to acidity|positive regulation of transcription from RNA polymerase II promoter in response to freezing|positive regulation of transcription from RNA polymerase II promoter in response to ethanol|replicative cell aging|age-dependent response to oxidative stress involved in chronological cell aging|positive regulation of transcription from RNA polymerase II promoter in response to hydrostatic pressure|positive regulation of transcription from RNA polymerase II promoter in response to nitrosative stress|positive regulation of transcription from RNA polymerase II promoter in response to cold|positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding cytosol|nucleus
YGL033W YGL033W HOP2 hom Verified 0.365552562611551 0.357349489048493 no 1664 0.378911733624571 1266 NA FF|FT CELL CYCLE NUCLEUS|CHROMOSOME Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair synapsis|reciprocal meiotic recombination protein binding|double-stranded DNA binding condensed nuclear chromosome
YJR122W YJR122W IBA57 hom Verified 0.365128199411228 0.357507855926875 no 1665 0.384876748783225 1276 NA FF|FT COFACTOR METABOLISM MITOCHONDRION Mitochondrial matrix protein involved in the incorporation of iron-sulfur clusters into mitochondrial aconitase-type proteins; activates the radical-SAM family members Bio2p and Lip5p; interacts with Ccr4p in the two-hybrid system iron-sulfur cluster assembly molecular_function mitochondrion|mitochondrial matrix
YBR113W_d YBR113W YBR113W hom Dubious 0.363226299026356 0.358217921746539 no 1666 0.32901316360347 1086 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CYC8 Unknown Unknown Unknown
YDR098C YDR098C GRX3 hom Verified 0.361944470052075 0.358696763679905 no 1667 0.352942586209982 1202 NA FT ION HOMEOSTASIS|CYTOSKELETON ORGANIZATION|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS NUCLEUS Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage; evidence exists indicating that the translation start site is not Met1 as currently annotated, but rather Met36 cellular iron ion homeostasis|cellular response to oxidative stress|actin cytoskeleton organization disulfide oxidoreductase activity cytosol|nucleus
YLR271W_p YLR271W YLR271W hom Uncharacterized 0.360630228645468 0.359187944353548 no 1668 0.340128023446896 1121 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS biological_process molecular_function nucleus|cytoplasm
YKR053C YKR053C YSR3 hom Verified 0.360530213721267 0.359225333177515 no 1669 0.365207922772018 1243 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Dihydrosphingosine 1-phosphate phosphatase; membrane protein involved in sphingolipid metabolism; YSR3 has a paralog, LCB3, that arose from the whole genome duplication phospholipid dephosphorylation|sphingolipid biosynthetic process sphingosine-1-phosphate phosphatase activity integral to membrane|endoplasmic reticulum
YMR004W YMR004W MVP1 hom Verified 0.360243488838158 0.359332527714149 no 1670 0.374432128397766 1261 NA FT PROTEIN LOCALIZATION|VACUOLAR TRANSPORT NUCLEUS Protein required for sorting proteins to the vacuole; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions; protein abundance increases in response to DNA replication stress protein targeting to vacuole phosphatidylinositol-3-phosphate binding nucleus|cytoplasm
YBR144C_d YBR144C YBR144C hom Dubious 0.359575976946746 0.359582125595351 no 1671 0.342332190557102 1123 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR144C is not an essential gene Unknown Unknown Unknown
YOR332W YOR332W VMA4 hom Verified 0.358050400123943 0.360152798267816 no 1672 0.373844003081927 1232 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Subunit E of the V1 domain of the vacuolar H+-ATPase (V-ATPase); V-ATPase is an electrogenic proton pump found throughout the endomembrane system; V1 domain has eight subunits; required for the V1 domain to assemble onto the vacuolar membrane; protein abundance increases in response to DNA replication stress vacuolar acidification proton-transporting ATPase activity, rotational mechanism vacuolar proton-transporting V-type ATPase, V1 domain|fungal-type vacuole membrane|integral to membrane
YER089C YER089C PTC2 hom Verified 0.357327640518674 0.360423269948652 no 1673 0.333631143151278 1122 NA FT CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION NUCLEUS Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; inactivates the DNA damage checkpoint; PTC2 has a paralog, PTC3, that arose from the whole genome duplication endoplasmic reticulum unfolded protein response|inactivation of MAPK activity involved in osmosensory signaling pathway|regulation of cyclin-dependent protein kinase activity|protein dephosphorylation|DNA damage checkpoint protein serine/threonine phosphatase activity nucleus|cytoplasm
YOL138C YOL138C RTC1 hom Verified 0.354734847253446 0.361394121091125 no 1674 0.363288601794288 1223 NA Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; null mutation suppresses cdc13-1 temperature sensitivity; has N-terminal WD-40 repeats and a C-terminal RING motif biological_process molecular_function ribosome|fungal-type vacuole|Seh1-associated complex|extrinsic to fungal-type vacuolar membrane
YER155C YER155C BEM2 hom Verified 0.354403000058689 0.361518443281857 no 1675 0.371635800955474 1254 NA FT SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION MITOCHONDRION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Rho GTPase activating protein (RhoGAP) involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence negative regulation of Rho protein signal transduction|fungal-type cell wall organization|establishment of cell polarity|actin cytoskeleton organization Rho GTPase activator activity cell cortex|incipient cellular bud site|mitochondrion|plasma membrane|mating projection tip|cytoplasm|cellular bud tip
YNL191W YNL191W DUG3 hom Verified 0.354298453378961 0.361557613351094 no 1676 0.354891257327717 1178 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Component of glutamine amidotransferase (GATase II); forms a complex with Dug2p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p) glutathione catabolic process peptidase activity|omega peptidase activity|gamma-glutamyltransferase activity|carbon-nitrogen ligase activity, with glutamine as amido-N-donor cytoplasm
YJL160C_p YJL160C YJL160C hom Uncharacterized 0.353932701388231 0.361694659541274 no 1677 0.387380961807837 1301 NA Putative protein of unknown function; member of the PIR (proteins with internal repeats) family of cell wall proteins; non-essential gene that is required for sporulation; mRNA is weakly cell cycle regulated, peaking in mitosis; YJL160C has a paralog, PIR1, that arose from the whole genome duplication biological_process molecular_function cellular_component
YGL076C YGL076C RPL7A hom Verified 0.353874041490769 0.361716640882866 no 1678 0.338471170322239 1140 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L7A; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7A has a paralog, RPL7B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit|cytoplasm
YDL219W YDL219W DTD1 hom Verified 0.353095506451332 0.362008420768345 no 1679 0.339864194774456 1131 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes Unknown D-leucyl-tRNA(Leu) deacylase activity|D-tyrosyl-tRNA(Tyr) deacylase activity cytoplasm
YJL116C YJL116C NCA3 hom Verified 0.352991763050262 0.362047307850427 no 1680 0.35292906897509 1186 NA FT MITOCHONDRION ORGANIZATION MITOCHONDRION Protein involved in mitochondrion organization; functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; member of the SUN family; expression induced in cells treated with the mycotoxin patulin; NCA3 has a paralog, UTH1, that arose from the whole genome duplication mitochondrion organization molecular_function cellular_component
YER140W YER140W EMP65 hom Verified 0.351604422356722 0.362567474087442 no 1681 0.357516336843419 1196 NA FT MITOCHONDRION ER membrane protein of unknown function; forms an ER-membrane associated protein complex with Slp1p; identified along with SLP1 in a screen for mutants defective in the unfolded protein response (UPR); proposed to function in the folding of integral membrane proteins; interacts genetically with MPS1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies protein folding in endoplasmic reticulum molecular_function mitochondrion|integral to membrane
YBR106W YBR106W PHO88 hom Verified 0.349003441560754 0.363543362920361 no 1682 0.404667920463319 1348 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations phosphate ion transport molecular_function mitochondrion|membrane
YLR023C YLR023C IZH3 hom Verified 0.34894595352608 0.363564942481657 no 1683 0.315518578688895 1078 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity cellular zinc ion homeostasis metal ion binding integral to membrane|endoplasmic reticulum|membrane
YGR254W YGR254W ENO1 hom Verified 0.347639078433979 0.364055627154137 no 1684 0.350998639357503 1179 NA FT MEMBRANE ORGANIZATION|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Enolase I, a phosphopyruvate hydratase; catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is repressed in response to glucose; protein abundance increases in response to DNA replication stress regulation of vacuole fusion, non-autophagic|gluconeogenesis|glycolysis phosphopyruvate hydratase activity mitochondrion|phosphopyruvate hydratase complex|plasma membrane|fungal-type vacuole|cytoplasm
YPL072W YPL072W UBP16 hom Verified 0.347144143789325 0.364241515595273 no 1685 0.340951841951601 1134 NA FT PROTEOLYSIS MITOCHONDRION Deubiquitinating enzyme anchored to the outer mitochondrial membrane, probably not important for general mitochondrial functioning, but may perform a more specialized function at mitochondria protein deubiquitination ubiquitin-specific protease activity mitochondrial outer membrane|cytoplasm
YOL061W YOL061W PRS5 hom Verified 0.346737846013584 0.364394137516842 no 1686 0.369202518511717 1246 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; forms cytoplasmic foci upon DNA replication stress fungal-type cell wall organization|5-phosphoribose 1-diphosphate biosynthetic process ribose phosphate diphosphokinase activity cytoplasm
YLR315W YLR315W NKP2 hom Verified 0.345562092660284 0.364835919225529 no 1687 0.408269894926668 1369 NA FT CELL CYCLE|CELL DIVISION NUCLEUS|CHROMOSOME|CYTOSKELETON KINETOCHORE Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2 biological_process molecular_function spindle pole body|kinetochore
YLR296W_d YLR296W YLR296W hom Dubious 0.345063580063369 0.365023286333928 no 1688 0.366493815461457 1229 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOL110W YOL110W SHR5 hom Verified 0.344993013270684 0.365049811630867 no 1689 0.365410497602899 1198 NA FT PROTEIN LOCALIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Subunit of a palmitoyltransferase, composed of Shr5p and Erf2p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; palmitoylation is required for Ras2p membrane localization protein targeting to membrane|protein palmitoylation palmitoyltransferase activity endoplasmic reticulum palmitoyltransferase complex|extrinsic to endoplasmic reticulum membrane
YDR222W_p YDR222W YDR222W hom Uncharacterized 0.343891112396417 0.365464087991878 no 1690 0.392641266668 1299 NA FT RESPONSE TO OXIDATIVE STRESS Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern biological_process molecular_function cytoplasm
YOL085C_d YOL085C YOL085C hom Dubious 0.343806778488081 0.36549580107892 no 1691 0.366927847722281 1220 NA Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A Unknown Unknown Unknown
YBR012C_d YBR012C YBR012C hom Dubious 0.342206963405864 0.366097572602226 no 1692 0.363587276072104 1191 NA Dubious open reading frame, unlikely to encode a functional protein; expression induced by iron-regulated transcriptional activator Aft2p Unknown Unknown Unknown
YLR452C YLR452C SST2 hom Verified 0.341454222654413 0.366380830632423 no 1693 0.363019256290557 1210 NA FT SIGNALING PLASMA MEMBRANE GTPase-activating protein for Gpa1p, regulates desensitization to alpha factor pheromone; also required to prevent receptor-independent signaling of the mating pathway; member of the RGS (regulator of G-protein signaling) family adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|signal transduction GTPase activator activity plasma membrane
YPL189C-A YPL189C-A COA2 hom Verified 0.340438103474453 0.366763314015769 no 1694 0.366503680150374 1216 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p mitochondrial respiratory chain complex IV assembly molecular_function mitochondrial matrix
YIL105C YIL105C SLM1 hom Verified 0.339411201234407 0.367149990760427 no 1695 0.350503937964195 1154 NA FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|SIGNALING|CYTOSKELETON ORGANIZATION MITOCHONDRION|PLASMA MEMBRANE Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; protein abundance increases in response to DNA replication stress; SLM1 has a paralog, SLM2, that arose from the whole genome duplication eisosome assembly|TOR signaling cascade|regulation of cell growth|actin filament bundle assembly|endosomal transport|establishment or maintenance of actin cytoskeleton polarity|actin cytoskeleton organization phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol binding|sphingolipid binding eisosome|mitochondrion|membrane raft|plasma membrane|cytoplasm
YMR158W-B_d YMR158W-B YMR158W-B hom Dubious 0.337310993632404 0.367941236559997 no 1696 0.349616660106848 1178 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene ATG16/YMR159C Unknown Unknown Unknown
YER154W YER154W OXA1 hom Verified 0.336836737064727 0.368119988765578 no 1697 0.377736930546519 1262 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial inner membrane insertase, mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane, interacts with mitochondrial ribosomes; conserved from bacteria to animals protein insertion into mitochondrial membrane from inner side|mitochondrial genome maintenance|mitochondrial proton-transporting ATP synthase complex assembly mitochondrial ribosome binding|membrane insertase activity mitochondrion|mitochondrial inner boundary membrane|integral to membrane|mitochondrial crista|mitochondrial large ribosomal subunit
YER017C YER017C AFG3 hom Verified 0.336820822109936 0.368125987772086 no 1698 0.379068249652005 1226 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Component, with Yta12p, of the mitochondrial inner membrane m-AAA protease; mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes; involved in cytoplasmic mRNA translation and aging proteolysis|signal peptide processing|protein complex assembly|protein import into mitochondrial intermembrane space metallopeptidase activity|protein binding|ATPase activity mitochondrion|mitochondrial inner boundary membrane|mitochondrial inner membrane|m-AAA complex
YPR060C YPR060C ARO7 hom Verified 0.334619960398367 0.368955892946773 no 1699 0.409656794479271 1386 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Chorismate mutase, catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis aromatic amino acid family biosynthetic process chorismate mutase activity nucleus|cytoplasm
YBL095W_p YBL095W YBL095W hom Uncharacterized 0.334142164706884 0.369136141964797 no 1700 0.335183334336496 1151 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YCL048W YCL048W SPS22 hom Verified 0.332841917418403 0.369626807488265 no 1701 0.368713160358862 1202 NA FT CELL WALL ORG/BIOGENESIS PLASMA MEMBRANE Protein of unknown function; SPS22 has a paralog, SPS2, that arose from the whole genome duplication; redundant with Sps2p for the organization of the beta-glucan layer of the spore wall ascospore wall assembly|fungal-type cell wall organization molecular_function plasma membrane
YDR251W YDR251W PAM1 hom Verified 0.332752178307473 0.369660679573213 no 1702 0.375312950779229 1235 NA FT OXIDATION-REDUCTION PROCESS SITE OF POLARIZED GROWTH Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype pseudohyphal growth molecular_function cellular bud|cellular bud neck
YDL059C YDL059C RAD59 hom Verified 0.332615357876093 0.369712324479327 no 1703 0.381639571349789 1251 NA FT RESPONSE TO DNA DAMAGE NUCLEUS Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p DNA strand renaturation|telomere maintenance via recombination|double-strand break repair via break-induced replication|double-strand break repair via single-strand annealing protein binding nucleus
YPL155C YPL155C KIP2 hom Verified 0.332269523623312 0.369842875236661 no 1704 0.333942723364769 1124 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION MITOCHONDRION|CYTOSKELETON Kinesin-related motor protein involved in mitotic spindle positioning, stabilizes microtubules by targeting Bik1p to the plus end; Kip2p levels are controlled during the cell cycle nuclear migration along microtubule|mitotic anaphase B|negative regulation of microtubule depolymerization microtubule motor activity mitochondrion|kinesin complex|cytoplasmic microtubule
YNL225C YNL225C CNM67 hom Verified 0.332089272624295 0.369910925065092 no 1705 0.389066256984744 1299 NA FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION NUCLEUS|CYTOSKELETON Component of the spindle pole body outer plaque; required for spindle orientation and mitotic nuclear migration; CNM67 has a paralog, ADY3, that arose from the whole genome duplication microtubule nucleation|mitotic spindle organization structural constituent of cytoskeleton outer plaque of spindle pole body|spindle pole body
YOL137W YOL137W BSC6 hom Verified 0.331669650835025 0.370069359884632 no 1706 0.38650033952117 1285 NA FT GOLGI APPARATUS Protein of unknown function containing 8 putative transmembrane seqments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression biological_process molecular_function COPI-coated vesicle|integral to membrane|clathrin-coated vesicle
YBR175W YBR175W SWD3 hom Verified 0.331306200238351 0.370206604207642 no 1707 0.364683931199754 1190 NA FT CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5 histone H3-K4 methylation|telomere maintenance|chromatin silencing at telomere histone methyltransferase activity (H3-K4 specific) Set1C/COMPASS complex
YNL077W YNL077W APJ1 hom Verified 0.329896623340055 0.370739037497529 no 1708 0.389273602976965 1297 NA FT NUCLEUS|MITOCHONDRION Chaperone with a role in SUMO-mediated protein degradation; member of the DnaJ-like family; conserved across eukaryotes; overexpression interferes with propagation of the [Psi+] prion; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress biological_process unfolded protein binding mitochondrion|nucleus|cytoplasm
YDL178W YDL178W DLD2 hom Verified 0.329704474366876 0.370811636286261 no 1709 0.403879944904194 1315 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION D-lactate dehydrogenase, located in the mitochondrial matrix lactate metabolic process actin binding|D-lactate dehydrogenase (cytochrome) activity mitochondrion|mitochondrial matrix
YDR359C YDR359C EAF1 hom Verified 0.329030901960344 0.371066165447234 no 1710 0.406359578976565 1322 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS HISTONE ACETYLTRANSFERASE Component of the NuA4 histone acetyltransferase complex; acts as a platform for assembly of NuA4 subunits into the native complex; required for initiation of pre-meiotic DNA replication, likely due to its requirement for expression of IME1 DNA repair|cellular protein complex assembly|chromatin modification molecular_function histone acetyltransferase complex|NuA4 histone acetyltransferase complex
YHR103W YHR103W SBE22 hom Verified 0.328768327973786 0.371165402045635 no 1711 0.373734535884479 1231 NA FT PROTEIN LOCALIZATION|CELL WALL ORG/BIOGENESIS GOLGI APPARATUS Protein involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; involved in bud growth fungal-type cell wall organization molecular_function cytoplasm
YMR276W YMR276W DSK2 hom Verified 0.328053576921234 0.371435576769406 no 1712 0.332757124498464 1100 NA FT CELL CYCLE|PROTEOLYSIS|CYTOSKELETON ORGANIZATION NUCLEUS Nuclear-enriched ubiquitin-like polyubiquitin-binding protein; required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle; involved in proteolysis; interacts with the proteasome; protein abundance increases in response to DNA replication stress ER-associated protein catabolic process|spindle pole body duplication associated with nuclear envelope protein binding, bridging nucleus
YDR264C YDR264C AKR1 hom Verified 0.326968781805584 0.371845748550963 no 1713 0.499856073474834 1675 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats; AKR1 has a paralog, AKR2, that arose from the whole genome duplication protein targeting to membrane|regulation of endocytosis|regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion|protein palmitoylation palmitoyltransferase activity integral to membrane|Golgi apparatus|membrane
YBL070C_d YBL070C YBL070C hom Dubious 0.326670581579383 0.371958526527011 no 1714 0.378023733894263 1263 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR121C YLR121C YPS3 hom Verified 0.326431902738752 0.372048801700868 no 1715 0.377995108154119 1277 NA FT CELL WALL ORG/BIOGENESIS|PROTEOLYSIS PLASMA MEMBRANE Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor fungal-type cell wall organization|cellular protein metabolic process aspartic-type endopeptidase activity anchored to plasma membrane|plasma membrane
YLL045C YLL045C RPL8B hom Verified 0.326337869976843 0.372084369516438 no 1716 0.342923942315256 1166 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal 60S subunit protein L8B; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8B has a paralog, RPL8A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YDR252W YDR252W BTT1 hom Verified 0.323849803106502 0.373025874428622 no 1717 0.373714323593206 1249 NA FT PROTEIN LOCALIZATION NUCLEUS Beta3 subunit of the heterotrimeric nascent polypeptide-associated complex which binds ribosomes via its beta-subunits in close proximity to nascent polypeptides; interacts with Caf130p of the CCR4-NOT complex; similar to human BTF3 'de novo' cotranslational protein folding unfolded protein binding nascent polypeptide-associated complex|CCR4-NOT complex
YPL111W YPL111W CAR1 hom Verified 0.322558156595425 0.37351494365511 no 1718 0.384514663178985 1267 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS|SITE OF POLARIZED GROWTH Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance regulation of ornithine metabolic process|arginine catabolic process to ornithine manganese ion binding|arginase activity|ornithine carbamoyltransferase inhibitor activity|zinc ion binding cytosol|nucleus|mating projection tip|cytoplasm
YHR149C YHR149C SKG6 hom Verified 0.320734392402637 0.3742058408681 no 1719 0.37784741257118 1257 NA FT SITE OF POLARIZED GROWTH Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p biological_process molecular_function cell cortex|incipient cellular bud site|integral to membrane|cellular bud neck|cellular bud tip
YOL151W YOL151W GRE2 hom Verified 0.320068428779678 0.374458228964302 no 1720 0.352134073167522 1195 NA FT LIPID METABOLISM|OXIDATION-REDUCTION PROCESS NUCLEUS 3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase (D-lactaldehyde dehydrogenase); stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress ergosterol metabolic process|filamentous growth methylglyoxal reductase (NADPH-dependent) activity|3-methylbutanol:NAD(P) oxidoreductase activity nucleus|cytoplasm
YER055C YER055C HIS1 hom Verified 0.320062726740097 0.374460390166007 no 1721 0.371286890829615 1207 NA FT KETONE METABOLISM|AMINO ACID METABOLISM ATP phosphoribosyltransferase, a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control histidine biosynthetic process ATP phosphoribosyltransferase activity cellular_component
YGL070C YGL070C RPB9 hom Verified 0.319040653401638 0.374847842686813 no 1722 0.400524518715808 1338 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE NUCLEUS RNA POL II, HOLOENZYME RNA polymerase II subunit B12.6; contacts DNA; mutations affect transcription start site selection and fidelity of transcription transcription initiation from RNA polymerase II promoter|maintenance of transcriptional fidelity during DNA-dependent transcription elongation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|response to DNA damage stimulus|transcription from RNA polymerase II promoter RNA-directed RNA polymerase activity DNA-directed RNA polymerase II, core complex
YDR269C_d YDR269C YDR269C hom Dubious 0.317722084856677 0.375347878661451 no 1723 0.367523314409479 1188 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YJL037W YJL037W IRC18 hom Verified 0.317680932705375 0.375363488018538 no 1724 0.380957107581338 1281 NA Putative protein of unknown function; expression induced in respiratory-deficient cells and in carbon-limited chemostat cultures; similar to adjacent ORF, YJL038C; null mutant displays increased levels of spontaneous Rad52p foci biological_process molecular_function cellular_component
YMR283C YMR283C RIT1 hom Verified 0.316732087985853 0.375723449348102 no 1725 0.338397483822977 1124 NA FT RNA PROCESSING 2'-O-ribosyl phosphate transferase, modifies the initiator methionine tRNA at position 64 to distinguish it from elongator methionine tRNA charged-tRNA amino acid modification transferase activity, transferring pentosyl groups cytoplasm
YOL060C YOL060C MAM3 hom Verified 0.316379182262071 0.375857358108688 no 1726 0.365872040972261 1226 NA FT ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS Protein required for normal mitochondrial morphology, has similarity to hemolysins cellular manganese ion homeostasis|mitochondrion organization molecular_function fungal-type vacuole membrane|integral to membrane
YGR194C YGR194C XKS1 hom Verified 0.316077266823673 0.37597193066378 no 1727 0.358988529103676 1179 NA FT CARBOHYDRATE METABOLISM Xylulokinase, converts D-xylulose and ATP to xylulose 5-phosphate and ADP; rate limiting step in fermentation of xylulose; required for xylose fermentation by recombinant S. cerevisiae strains xylulose catabolic process xylulokinase activity cytoplasm
YLR307W YLR307W CDA1 hom Verified 0.315509084304317 0.376187577379611 no 1728 0.358007773859314 1190 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM Chitin deacetylase, together with Cda2p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall ascospore wall assembly chitin deacetylase activity chitosan layer of spore wall
YLL019C YLL019C KNS1 hom Verified 0.313572816574506 0.376922754073193 no 1729 0.347405959866119 1160 NA FT PROTEIN PHOSPHORYLATION Protein kinase involved in negative regulation of PolIII transcription; effector kinase of the TOR signaling pathway and phosphorylates Rpc53p to regulate ribosome and tRNA biosynthesis; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues; capable of autophosphorylation negative regulation of transcription from RNA polymerase III promoter|protein autophosphorylation|protein phosphorylation protein serine/threonine kinase activity|protein tyrosine kinase activity|protein kinase activity nucleus|cytoplasm
YKR003W YKR003W OSH6 hom Verified 0.313252734722551 0.377044328231062 no 1730 0.353021822178265 1187 NA FT VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Member of an oxysterol-binding protein family; overlapping, redundant functions in sterol metabolism and which collectively perform a function essential for viability; GFP-fusion protein localizes to the cell periphery; overexpression extends lifespan by promoting vacuolar fusion sterol homeostasis|maintenance of cell polarity|endocytosis|sterol transport|exocytosis|sterol metabolic process phosphatidic acid binding|lipid binding|phosphatidylinositol-3,4-bisphosphate binding|oxysterol binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-5-phosphate binding|phosphatidylinositol-4-phosphate binding cortical endoplasmic reticulum|extrinsic to membrane|cytoplasm
YGR291C_d YGR291C YGR291C hom Dubious 0.312778670283619 0.377224410771344 no 1731 0.38154655029807 1232 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGL179C YGL179C TOS3 hom Verified 0.312278049512206 0.37741461023699 no 1732 0.364531562229942 1254 NA FT CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome protein phosphorylation|glucose metabolic process protein serine/threonine kinase activity|protein kinase activity nucleus|cytoplasm
YDR534C YDR534C FIT1 hom Verified 0.312192094307225 0.377447269952756 no 1733 0.328511011773139 1126 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall siderophore transport molecular_function fungal-type cell wall
YGR176W_d YGR176W YGR176W hom Dubious 0.311827411226411 0.377585845427827 no 1734 0.36799290704018 1225 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YEL067C_p YEL067C YEL067C hom Uncharacterized 0.311708532665978 0.377631021352438 no 1735 0.384853061175803 1273 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YMR053C YMR053C STB2 hom Verified 0.310787660895264 0.377981025338878 no 1736 0.366690713408048 1238 NA FT NUCLEUS|CHROMOSOME Protein that interacts with Sin3p in a two-hybrid assay and is part of a large protein complex with Sin3p and Stb1p biological_process molecular_function Sin3-type complex
YMR278W YMR278W PGM3 hom Verified 0.310303953796328 0.378164912380488 no 1737 0.359910273278848 1208 NA FT CARBOHYDRATE METABOLISM NUCLEUS Phosphoglucomutase, catalyzes interconversion of glucose-1-phosphate and glucose-6-phospate; transcription induced in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; non-essential biological_process phosphoglucomutase activity nucleus|cytoplasm
YIL138C YIL138C TPM2 hom Verified 0.309534204098221 0.378457598836882 no 1738 0.394557176091464 1308 NA FT VESICLE-MEDIATED TRANSPORT|CELL DIVISION|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|RNA LOCALIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Minor isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p; TPM2 has a paralog, TPM1, that arose from the whole genome duplication vacuole inheritance|exocytosis|intracellular mRNA localization|budding cell apical bud growth|budding cell isotropic bud growth|mitochondrion inheritance|actin polymerization or depolymerization|vesicle-mediated transport|actin filament organization|establishment of cell polarity|actin filament bundle assembly actin lateral binding cellular bud neck contractile ring|actin filament bundle
YDL194W YDL194W SNF3 hom Verified 0.309195406839012 0.378586443825614 no 1739 0.371262138160896 1235 NA FT CELL CYCLE|SIGNALING PLASMA MEMBRANE Plasma membrane low glucose sensor, regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; also senses fructose and mannose; SNF3 has a paralog, RGT2, that arose from the whole genome duplication mannose transport|glucose transport|signal transduction|negative regulation of meiosis|detection of glucose|fructose transport glucose transmembrane transporter activity|receptor activity|glucose binding integral to membrane|plasma membrane
YEL047C YEL047C FRD1 hom Verified 0.308867937787944 0.378710993512228 no 1740 0.37663608464379 1254 NA FT OXIDATION-REDUCTION PROCESS MITOCHONDRION Soluble fumarate reductase; required with isoenzyme Osm1p for anaerobic growth; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to Arxula adeninovorans fumarate reductase; protein abundance increases in response to DNA replication stress; FRD1 has a paralog, OSM1, that arose from the whole genome duplication cellular response to anoxia fumarate reductase (NADH) activity cytosol|mitochondrion|ribosome|plasma membrane
YDL122W YDL122W UBP1 hom Verified 0.308698856860467 0.378775306740251 no 1741 0.369573937914765 1218 NA FT PROTEOLYSIS ENDOPLASMIC RETICULUM Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains protein deubiquitination ubiquitin-specific protease activity endoplasmic reticulum|cytoplasm
YKR035W-A YKR035W-A DID2 hom Verified 0.308657664468879 0.378790975578287 no 1742 0.377952111656598 1241 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM Class E protein of the vacuolar protein-sorting (Vps) pathway; binds Vps4p and directs it to dissociate ESCRT-III complexes; forms a functional and physical complex with Ist1p; human ortholog may be altered in breast tumors late endosome to vacuole transport via multivesicular body sorting pathway|late endosome to vacuole transport|protein targeting to vacuole molecular_function late endosome|cytoplasm
YDR162C YDR162C NBP2 hom Verified 0.308389295284137 0.378893063220612 no 1743 0.440508478744948 1455 NA FF|FT PROTEIN PHOSPHORYLATION NUCLEUS Protein involved in the HOG (high osmolarity glycerol) pathway; negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex; interacts with Bck1p and down regulates the cell wall integrity pathway; found in the nucleus and cytoplasm, contains an SH3 domain and a Ptc1p binding domain (PBM) negative regulation of protein kinase activity|response to heat|hyperosmotic response molecular_function nucleus|cytoplasm
YOR265W YOR265W RBL2 hom Verified 0.308291193190612 0.378930383367817 no 1744 0.393183913976024 1310 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION CYTOSKELETON Protein involved in microtubule morphogenesis; required for protection from excess free beta-tubulin; proposed to be involved the folding of beta-tubulin; similar to mouse beta-tubulin cofactor A; protein abundance increases in response to DNA replication stress tubulin complex assembly|tubulin complex biogenesis tubulin binding|beta-tubulin binding cytoplasm
YIL090W YIL090W ICE2 hom Verified 0.307195007316202 0.379347472756494 no 1745 0.386718878077436 1298 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Integral ER membrane protein with type-III transmembrane domains; required for maintenance of ER zinc homeostasis; necessary for efficient targeting of Trm1p tRNA methyltransferase to inner nuclear membrane; mutations cause defects in cortical ER morphology in both the mother and daughter cells endoplasmic reticulum inheritance molecular_function integral to endoplasmic reticulum membrane|integral to membrane|endoplasmic reticulum
YMR025W YMR025W CSI1 hom Verified 0.306437731507594 0.379635691821745 no 1746 0.366570508499547 1223 NA FT SIGNALING NUCLEUS Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling; functional equivalent of canonical Csn6 subunit of the COP9 signalosome adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|cullin deneddylation molecular_function signalosome
YIR023W YIR023W DAL81 hom Verified 0.305450258798896 0.380011624253896 no 1747 0.451294920017951 1456 NA FF|FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|RESPONSE TO NUTRIENT LEVELS NUCLEUS Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism nitrogen utilization|nitrogen catabolite activation of transcription from RNA polymerase II promoter|gamma-aminobutyric acid catabolic process|urea catabolic process RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor recruiting transcription factor activity nucleus
YJR074W YJR074W MOG1 hom Verified 0.303768848738252 0.380652000515257 no 1748 0.375064173346873 1241 NA FT PROTEIN LOCALIZATION|RNA LOCALIZATION NUCLEUS Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p protein import into nucleus Ran GTPase binding nucleus
YOR333C_d YOR333C YOR333C hom Dubious 0.302423173648366 0.381164745642617 no 1749 0.372074224216722 1218 NA Dubious open reading frame, unlikely to encode a functional protein; overlaps 5' end of MRS2 gene required for respiratory growth Unknown Unknown Unknown
YPL165C YPL165C SET6 hom Verified 0.300989754965756 0.381711153424865 no 1750 0.372134781327779 1208 NA SET domain protein of unknown function; deletion heterozygote is sensitive to compounds that target ergosterol biosynthesis, may be involved in compound availability biological_process molecular_function cellular_component
YHR071W YHR071W PCL5 hom Verified 0.300463698477023 0.381911741168318 no 1751 0.352298479981444 1193 NA FT CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS NUCLEUS Cyclin, interacts with and phosphorylated by Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity negative regulation of sequence-specific DNA binding transcription factor activity|regulation of protein stability|negative regulation of macroautophagy cyclin-dependent protein kinase regulator activity cyclin-dependent protein kinase holoenzyme complex|nucleus
YBR032W_d YBR032W YBR032W hom Dubious 0.299934212340535 0.382113668670356 no 1752 0.351998342907628 1186 NA Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data Unknown Unknown Unknown
YPR167C YPR167C MET16 hom Verified 0.299689744344728 0.382206911042695 no 1753 0.381675388608698 1281 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS 3'-phosphoadenylsulfate reductase, reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)|sulfur amino acid metabolic process phosphoadenylyl-sulfate reductase (thioredoxin) activity cytoplasm
YMR031W-A_d YMR031W-A YMR031W-A hom Dubious 0.299495333004634 0.382281066216789 no 1754 0.382779936310215 1245 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C Unknown Unknown Unknown
YFR053C YFR053C HXK1 hom Verified 0.298668374793289 0.382596544746019 no 1755 0.401744547821845 1322 NA FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Hexokinase isoenzyme 1; a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves hexokinase Hxk2p; HXK1 has a paralog, HXK2, that arose from the whole genome duplication mannose metabolic process|glucose import|glycolysis|fructose import|glucose metabolic process|fructose metabolic process hexokinase activity cytosol|mitochondrion|cytoplasm
YPL123C YPL123C RNY1 hom Verified 0.29858106184945 0.382629858549354 no 1756 0.370098194818017 1239 NA Vacuolar RNase of the T(2) family, relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; promotes apoptosis under stress conditions and this function is independent of its catalytic activity cell morphogenesis|RNA catabolic process|apoptotic process endoribonuclease activity cytosol|extracellular region|vacuole
YGR097W YGR097W ASK10 hom Verified 0.297248475988172 0.383138407453798 no 1757 0.391931022839896 1290 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO OXIDATIVE STRESS NUCLEUS RNA POL II, HOLOENZYME Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication cellular protein catabolic process|cellular response to oxidative stress|positive regulation of transcription from RNA polymerase II promoter|positive regulation of glycerol transport molecular_function DNA-directed RNA polymerase II, holoenzyme|cytoplasm
YKR051W_p YKR051W YKR051W hom Uncharacterized 0.297179994269634 0.383164547282181 no 1758 0.386828732998124 1288 NA Putative protein of unknown function biological_process molecular_function integral to membrane
YDR501W YDR501W PLM2 hom Verified 0.29593145439425 0.383641214602832 no 1759 0.365598580379772 1227 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; induced in response to DNA damaging agents and deletion of telomerase; PLM2 has a paralog, TOS4, that arose from the whole genome duplication response to DNA damage stimulus chromatin binding nuclear chromatin
YKR085C YKR085C MRPL20 hom Verified 0.294433938989687 0.384213168040893 no 1760 0.377200359161552 1247 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YPL248C YPL248C GAL4 hom Verified 0.294100145693029 0.384340689779069 no 1761 0.374790760826896 1241 NA FT TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS NUCLEUS DNA-binding transcription factor required for the activation of the GAL genes in response to galactose; repressed by Gal80p and activated by Gal3p galactose metabolic process|positive regulation of transcription from RNA polymerase II promoter by galactose RNA polymerase II transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity nucleus
YFR008W YFR008W FAR7 hom Verified 0.293400407884409 0.384608056857924 no 1762 0.388165257073261 1296 NA FT CELL CYCLE|SIGNALING Protein involved in recovery from pheromone-induced cell cycle arrest; acts in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p; protein abundance increases in response to DNA replication stress re-entry into mitotic cell cycle after pheromone arrest molecular_function cellular_component
YPR185W YPR185W ATG13 hom Verified 0.293216172322035 0.384678461680131 no 1763 0.380930300688869 1250 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Regulatory subunit of the Atg1p signaling complex; stimulates Atg1p kinase activity; required for vesicle formation during autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; involved in Atg9p, Atg23p, and Atg27p cycling piecemeal microautophagy of nucleus|mitochondrion degradation|macroautophagy|activation of protein kinase activity|CVT pathway protein kinase regulator activity Atg1p signaling complex|extrinsic to membrane
YHL012W_p YHL012W YHL012W hom Uncharacterized 0.293008213919311 0.384757936652496 no 1764 0.360969505582405 1216 NA Putative UTP glucose-1-phosphate uridylyltransferase; YHL012W has a paralog, UGP1, that arose from the whole genome duplication biological_process molecular_function cellular_component
YJL084C YJL084C ALY2 hom Verified 0.291582768298268 0.38530282604397 no 1765 0.371002181583841 1254 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION Alpha arrestin that controls nutrient-mediated intracellular sorting of permease Gap1p; interacts with AP-1 subunit Apl4p; phosphorylated by Npr1p and also by cyclin-CDK complex Pcl7p-Pho85p; promotes endocytosis of plasma membrane proteins; ALY2 has a paralog, ALY1, that arose from the whole genome duplication Unknown|regulation of intracellular transport|ubiquitin-dependent endocytosis protein binding, bridging|ubiquitin protein ligase binding late endosome|cytoplasm|early endosome
YDR430C YDR430C CYM1 hom Verified 0.287650509112787 0.386807138712036 no 1766 0.372652396830125 1211 NA FT PROTEOLYSIS MITOCHONDRION Lysine-specific metalloprotease of the mitochondrial intermembrane space, member of the pitrilysin family; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology proteolysis|proteolysis involved in cellular protein catabolic process metalloendopeptidase activity mitochondrion|mitochondrial intermembrane space
YER109C YER109C FLO8 hom Verified 0.287019963503939 0.387048517195635 no 1767 0.377662844128734 1252 NA FT TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM NUCLEUS Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this gene biofilm formation|Unknown|positive regulation of starch catabolic process by positive regulation of transcription from RNA polymerase II promoter|positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus|cytoplasm
YJL023C YJL023C PET130 hom Verified 0.28679462425492 0.38713478967112 no 1768 0.381955764846981 1263 NA FT MITOCHONDRION Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YBR229C YBR229C ROT2 hom Verified 0.286330479756646 0.387312507725953 no 1769 0.385430699572826 1284 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM ENDOPLASMIC RETICULUM|MITOCHONDRION Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations fungal-type cell wall biogenesis alpha-glucosidase activity glucosidase II complex|mitochondrion|endoplasmic reticulum|endoplasmic reticulum lumen
YML078W YML078W CPR3 hom Verified 0.285791353364044 0.387518965533502 no 1770 0.3951035457085 1319 NA FT MITOCHONDRION Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; involved in protein refolding after import into mitochondria protein folding|apoptotic process peptidyl-prolyl cis-trans isomerase activity mitochondrion
YCL039W YCL039W GID7 hom Verified 0.285752513571782 0.387533840414669 no 1771 0.384430745073905 1268 NA FT KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS NUCLEUS Subunit of GID Complex that binds directly to central component Vid30p; GID complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; Gid7p contains six WD40 repeats; computational analysis suggests that Gid7p and Moh1p have similar functions negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process molecular_function nucleus|GID complex|cytoplasm
YER097W_d YER097W YER097W hom Dubious 0.285234799856031 0.387732130405567 no 1772 0.427417332118731 1404 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YJL007C_d YJL007C YJL007C hom Dubious 0.285123332037023 0.387774827627029 no 1773 0.389081458405316 1290 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOR321W YOR321W PMT3 hom Verified 0.284333869861494 0.388077266195672 no 1774 0.376848108592524 1254 NA FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt5p, can instead interact with Pmt1p in some conditions; antifungal drug target; PMT3 has a paralog, PMT2, that arose from the whole genome duplication protein O-linked glycosylation|protein O-linked mannosylation dolichyl-phosphate-mannose-protein mannosyltransferase activity integral to membrane|dolichyl-phosphate-mannose-protein mannosyltransferase complex
YJL123C YJL123C MTC1 hom Verified 0.28422363270444 0.388119502843679 no 1775 0.384204959496543 1285 NA FT GOLGI APPARATUS Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to COPI-coated vesicles (early Golgi); mtc1 is synthetically lethal with cdc13-1 biological_process molecular_function COPI-coated vesicle|ribosome|Golgi apparatus|cytoplasm
YLR210W YLR210W CLB4 hom Verified 0.284139036947254 0.388151916053974 no 1776 0.385417423462134 1252 NA FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION NUCLEUS|CYTOSKELETON B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation G2/M transition of mitotic cell cycle|S phase of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|positive regulation of spindle pole body separation cyclin-dependent protein kinase regulator activity nucleus|spindle pole body|cytoplasm
YKR092C YKR092C SRP40 hom Verified 0.283497010084232 0.388397936651276 no 1777 0.389689578736459 1270 NA FT NUCLEUS Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140 nucleocytoplasmic transport molecular_function nucleolus
YLR312W-A YLR312W-A MRPL15 hom Verified 0.282094437060253 0.388935549335877 no 1778 0.393368134401444 1343 NA FT RNA PROCESSING|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YKR076W YKR076W ECM4 hom Verified 0.28177739836328 0.389057101240608 no 1779 0.393721981680975 1300 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS Omega class glutathione transferase; not essential; similar to Ygr154cp; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm fungal-type cell wall organization|glutathione metabolic process glutathione transferase activity cytoplasm
YMR253C_p YMR253C YMR253C hom Uncharacterized 0.281335270864509 0.389226630032108 no 1780 0.387856250671834 1327 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene biological_process molecular_function integral to membrane|cytoplasm
YNL138W YNL138W SRV2 hom Verified 0.280189056958489 0.389666230925298 no 1781 0.462515597177581 1529 NA FT SIGNALING|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON CAP (cyclase-associated protein) subunit of adenylyl cyclase complex; N-terminus binds adenylyl cyclase and facilitates activation by RAS; C-terminus binds ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis cytoskeleton organization|Ras protein signal transduction cytoskeletal protein binding|adenylate cyclase binding mating projection tip|actin cortical patch
YKL120W YKL120W OAC1 hom Verified 0.280021739447806 0.389730413080618 no 1782 0.383999477440049 1286 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Mitochondrial inner membrane transporter, transports oxaloacetate, sulfate, thiosulfate, and isopropylmalate; member of the mitochondrial carrier family sulfate transport|oxaloacetate transport|isopropylmalate transport secondary active sulfate transmembrane transporter activity|oxaloacetate secondary active transmembrane transporter activity|isopropylmalate transmembrane transporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YNL120C_d YNL120C YNL120C hom Dubious 0.279924234810279 0.389767816755966 no 1783 0.383417850601715 1272 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; deletion enhances replication of Brome mosaic virus in S. cerevisiae, but likely due to effects on the overlapping gene Unknown Unknown Unknown
YER117W YER117W RPL23B hom Verified 0.279088177480756 0.390088577906562 no 1784 0.388913473644771 1275 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L23B; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23B has a paralog, RPL23A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YNR073C_p YNR073C YNR073C hom Uncharacterized 0.27843176137299 0.390340470502089 no 1785 0.427618951468542 1412 NA Putative mannitol dehydrogenase; identical in amino acid sequence to Dsf1p biological_process mannitol dehydrogenase activity cellular_component
YGL161C YGL161C YIP5 hom Verified 0.278363697952259 0.39036659174132 no 1786 0.390804701215063 1256 NA FT GOLGI APPARATUS Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport biological_process Rab GTPase binding integral to membrane|Golgi apparatus
YGL101W_p YGL101W YGL101W hom Uncharacterized 0.276950600202735 0.390909019114862 no 1787 0.388767559643388 1273 NA FT NUCLEUS Putative protein of unknown function; non-essential gene with similarity to YBR242W; interacts with the DNA helicase Hpr5p biological_process molecular_function nucleus|cytoplasm
YKR001C YKR001C VPS1 hom Verified 0.276885391703671 0.390934054982259 no 1788 0.434297951653296 1400 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION|VACUOLAR TRANSPORT|PEROXISOME ORGANIZATION MITOCHONDRION|CYTOSKELETON Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, endocytosis, late Golgi-retention of some proteins, regulation of peroxisome biogenesis vacuolar transport|peroxisome fission|endocytosis|actin cytoskeleton organization|protein retention in Golgi apparatus|peroxisome organization|lipid tube assembly|protein targeting to vacuole GTPase activity mitochondrial outer membrane|fungal-type vacuole membrane|peroxisome|actin cortical patch
YNL257C YNL257C SIP3 hom Verified 0.276190350318566 0.391200934214363 no 1789 0.424232723674844 1395 NA FT TRANSCRIPTION FROM RNA POL II Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog, YSP1, that arose from the whole genome duplication positive regulation of transcription from RNA polymerase II promoter transcription cofactor activity integral to membrane
YHR098C YHR098C SFB3 hom Verified 0.275766928482658 0.391363543171953 no 1790 0.373410716117415 1267 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS|SITE OF POLARIZED GROWTH Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb2p cargo loading into COPII-coated vesicle signal sequence binding COPII vesicle coat|mating projection tip
YOR127W YOR127W RGA1 hom Verified 0.274664391441264 0.391787045408268 no 1791 0.404466813203572 1353 NA FT SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON GTPase-activating protein for polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; relocalizes from bud neck to cytoplasm upon DNA replication stress budding cell isotropic bud growth|pheromone-dependent signal transduction involved in conjugation with cellular fusion|pseudohyphal growth|actin filament organization|establishment of cell polarity|small GTPase mediated signal transduction|invasive growth in response to glucose limitation|budding cell apical bud growth Rho GTPase activator activity cellular bud neck split septin rings
YOL036W_p YOL036W YOL036W hom Uncharacterized 0.27370695407698 0.392154916595766 no 1792 0.395556307275933 1300 NA Protein of unknown function; potential Cdc28p substrate; YOL036W has a paralog, YIR016W, that arose from the whole genome duplication biological_process molecular_function cellular_component
YNL176C_p YNL176C TDA7 hom Uncharacterized 0.273568133655267 0.392208262856241 no 1793 0.395115847947988 1294 NA Cell cycle-regulated gene of unknown function, promoter bound by Fkh2p; null mutant is sensitive to expression of the top1-T722A allele biological_process molecular_function fungal-type vacuole
YHR184W YHR184W SSP1 hom Verified 0.273388757435963 0.392277197000614 no 1794 0.394736726214383 1328 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION Protein involved in the control of meiotic nuclear division and coordination of meiosis with spore formation; transcription is induced midway through meiosis ascospore wall assembly|protein complex assembly molecular_function prospore membrane
YDR261C YDR261C EXG2 hom Verified 0.273076792781667 0.392397092830588 no 1795 0.387033743266398 1293 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM PLASMA MEMBRANE Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor fungal-type cell wall organization glucan exo-1,3-beta-glucosidase activity fungal-type cell wall
YDR405W YDR405W MRP20 hom Verified 0.272734209449676 0.392528767952232 no 1796 0.375379399722607 1264 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YNL099C YNL099C OCA1 hom Verified 0.272059629346473 0.392788085103894 no 1797 0.407171261774646 1327 NA FF|FT RESPONSE TO OXIDATIVE STRESS Putative protein tyrosine phosphatase, required for cell cycle arrest in response to oxidative damage of DNA cellular response to oxidative stress protein tyrosine phosphatase activity cytoplasm
YPR006C YPR006C ICL2 hom Verified 0.271925801545651 0.392839535870002 no 1798 0.396514478997726 1325 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION 2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol threonine catabolic process|propionate metabolic process methylisocitrate lyase activity mitochondrion|mitochondrial matrix
YFL041W-A_p YFL041W-A YFL041W-A hom Uncharacterized 0.27129872351788 0.393080644075968 no 1799 0.388831444751486 1270 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YBR156C YBR156C SLI15 hom Verified 0.270663167311404 0.393325053954505 no 1800 0.395575878788123 1293 NA FT CELL DIVISION|PROTEIN PHOSPHORYLATION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME|CYTOSKELETON Subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly chromosome segregation|protein phosphorylation|regulation of cytokinesis protein kinase activator activity spindle microtubule|spindle midzone|chromosome passenger complex|kinetochore microtubule
YKL121W_p YKL121W DGR2 hom Uncharacterized 0.270425203070175 0.393416576450688 no 1801 0.392689919889441 1289 NA Protein of unknown function; null mutant is resistant to 2-deoxy-D-glucose and displays abnormally elongated buds biological_process molecular_function cellular_component
YIL164C YIL164C NIT1 hom Verified 0.269775585171185 0.393666453421848 no 1802 0.373657680872871 1243 NA Nitrilase, member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene biological_process nitrilase activity cellular_component
YMR265C_p YMR265C YMR265C hom Uncharacterized 0.269468068433934 0.393784755698348 no 1803 0.388596718192687 1276 NA Putative protein of unknown function biological_process molecular_function cellular_component
YGL121C YGL121C GPG1 hom Verified 0.269124841512988 0.393916807327682 no 1804 0.37612943905093 1259 NA FT SIGNALING Proposed gamma subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p; involved in regulation of pseudohyphal growth; requires Gpb1p or Gpb2p to interact with Gpa2p; overproduction causes prion curing signal transduction|invasive growth in response to glucose limitation signal transducer activity cellular_component
YJL077W-B_p YJL077W-B YJL077W-B hom Uncharacterized 0.268884364618731 0.394009334627809 no 1805 0.442751936717306 1469 NA Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YER051W YER051W JHD1 hom Verified 0.268507246876381 0.394154448708417 no 1806 0.387414345455803 1260 NA FT CHROMATIN ORGANIZATION|OXIDATION-REDUCTION PROCESS NUCLEUS JmjC domain family histone demethylase specific for H3-K36, similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe histone demethylation methylated histone residue binding|histone demethylase activity (H3-K36 specific) cellular_component
YER124C YER124C DSE1 hom Verified 0.267828074009047 0.394415829989432 no 1807 0.391648779013857 1292 NA FT CELL CYCLE|SIGNALING|CELL WALL ORG/BIOGENESIS|CELL DIVISION SITE OF POLARIZED GROWTH Daughter cell-specific protein, may regulate cross-talk between the mating and filamentation pathways; deletion affects cell separation after division and sensitivity to alpha-factor and drugs affecting the cell wall; relocalizes from bud neck to cytoplasm upon DNA replication stress cytokinesis, completion of separation|regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion|invasive growth in response to glucose limitation molecular_function cellular bud neck
YKR028W YKR028W SAP190 hom Verified 0.267405719803817 0.394578397988331 no 1808 0.394143716461769 1311 NA FT CELL CYCLE|RNA PROCESSING|SIGNALING Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication TOR signaling cascade|dephosphorylation|G1/S transition of mitotic cell cycle|tRNA wobble uridine modification molecular_function cytoplasm
YGR026W_p YGR026W YGR026W hom Uncharacterized 0.266168289504221 0.39505480184072 no 1809 0.406983107692258 1348 NA FT PLASMA MEMBRANE Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery biological_process molecular_function integral to membrane
YDR456W YDR456W NHX1 hom Verified 0.265722218905556 0.395226575083732 no 1810 0.400911964632094 1326 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS GOLGI APPARATUS Na+/H+ and K+/H+ exchanger, required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion sodium ion transmembrane transport|potassium ion transmembrane transport|cellular monovalent inorganic cation homeostasis|vacuolar acidification sodium:hydrogen antiporter activity|potassium:hydrogen antiporter activity trans-Golgi network|late endosome|fungal-type vacuole membrane|integral to membrane|early endosome
YGR041W YGR041W BUD9 hom Verified 0.264786134708703 0.395587109337656 no 1811 0.383865813404293 1264 NA FT CELL CYCLE|CELL DIVISION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Protein involved in bud-site selection; mutant has increased aneuploidy tolerance; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the distal pole cellular bud site selection molecular_function plasma membrane|cellular bud neck
YPL137C YPL137C GIP3 hom Verified 0.264504066991712 0.395695765684696 no 1812 0.401127405997309 1358 NA FT CHROMOSOME SEGREGATION ENDOPLASMIC RETICULUM|MITOCHONDRION Cytoplasmic protein that regulates protein phosphatase 1 Glc7p; overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments; GIP3 has a paralog, HER1, that arose from the whole genome duplication chromosome segregation|regulation of phosphoprotein phosphatase activity protein phosphatase type 1 regulator activity|protein phosphatase 1 binding mitochondrion|ribosome|endoplasmic reticulum|cytoplasm
YBL057C YBL057C PTH2 hom Verified 0.264363035276358 0.395750096073192 no 1813 0.413932989853934 1373 NA FT PROTEOLYSIS MITOCHONDRION One of two (see also PTH1) mitochondrially-localized peptidyl-tRNA hydrolases; negatively regulates the ubiquitin-proteasome pathway via interactions with ubiquitin-like ubiquitin-associated proteins; dispensable for cell growth negative regulation of proteasomal ubiquitin-dependent protein catabolic process aminoacyl-tRNA hydrolase activity mitochondrial outer membrane|mitochondrion|cytoplasm
YPL051W YPL051W ARL3 hom Verified 0.263037925300582 0.396260673943156 no 1814 0.417961811882479 1360 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING ENDOMEMBRANE SYSTEM|GOLGI APPARATUS GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor intracellular protein transport|Golgi to plasma membrane protein transport|protein localization to organelle GTPase activity Golgi apparatus|nuclear outer membrane-endoplasmic reticulum membrane network
YOR273C YOR273C TPO4 hom Verified 0.262334893692366 0.396531631238161 no 1815 0.493529083102201 1659 NA FF|FT PLASMA MEMBRANE Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane spermidine transport|spermine transport spermidine transmembrane transporter activity|spermine transmembrane transporter activity fungal-type vacuole membrane|integral to membrane|plasma membrane
YOR205C YOR205C GEP3 hom Verified 0.261506521874812 0.396850960366185 no 1816 0.382687090099403 1274 NA FT MITOCHONDRION Protein required for mitochondrial ribosome small subunit biogenesis; null mutant is defective in respiration and in maturation of 15S rRNA; protein is localized to the mitochondrial inner membrane; null mutant interacts synthetically with prohibitin (phb1) maturation of SSU-rRNA molecular_function mitochondrion|mitochondrial inner membrane
YGL231C YGL231C EMC4 hom Verified 0.260980125360634 0.397053916969001 no 1817 0.411075898356919 1343 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm ZK616.6/EMC-4, fly CG11137, human TMM85 protein folding in endoplasmic reticulum molecular_function ER membrane protein complex|endoplasmic reticulum
YNL201C YNL201C PSY2 hom Verified 0.260276970951572 0.397325067556038 no 1818 0.445709450016228 1465 NA FT CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Subunit of protein phosphatase PP4 complex; active complex is composed of catalytic subunit Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; Pph3p and Psy2p localize to foci on meiotic chromosomes; putative homolog of mammalian R3 Unknown|response to DNA damage stimulus|protein dephosphorylation|signal transduction involved in meiotic recombination checkpoint protein serine/threonine phosphatase activity condensed nuclear chromosome|nucleus
YPR100W YPR100W MRPL51 hom Verified 0.260179282898788 0.397362741977722 no 1819 0.416103949266692 1384 NA FT TRANSLATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation|aerobic respiration structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YOL076W YOL076W MDM20 hom Verified 0.25956878758344 0.397598207574113 no 1820 0.435889944886573 1447 NA FF|FT MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly mitochondrion inheritance|N-terminal peptidyl-methionine acetylation|cytoskeleton organization peptide alpha-N-acetyltransferase activity NatB complex
YDR278C_d YDR278C YDR278C hom Dubious 0.259388820136936 0.397667627422226 no 1821 0.39308137575571 1322 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR524W-C_p YDR524W-C YDR524W-C hom Uncharacterized 0.258591811905811 0.397975100784449 no 1822 0.401681802938294 1305 NA Putative protein of unknown function; small ORF identified by SAGE; deletion strains are moderately sensitive to the radiomimetic drug bleomycin biological_process molecular_function cellular_component
YGL088W_d YGL088W YGL088W hom Dubious 0.25856484014576 0.397985507179085 no 1823 0.391145254069492 1308 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps snR10, a snoRNA required for preRNA processing Unknown Unknown Unknown
YNL233W YNL233W BNI4 hom Verified 0.258232025335829 0.398113921612719 no 1824 0.43316503356745 1423 NA FT PROTEIN LOCALIZATION|CELL DIVISION|CARBOHYDRATE METABOLISM SITE OF POLARIZED GROWTH|CYTOSKELETON Targeting subunit for Glc7p protein phosphatase, localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p asymmetric protein localization|barrier septum assembly|chitin biosynthetic process protein binding incipient cellular bud site|cellular bud neck septin collar|cellular bud neck|septin ring
YER173W YER173W RAD24 hom Verified 0.257969870249916 0.398215080222012 no 1825 0.404735031493118 1319 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein reciprocal meiotic recombination|DNA damage checkpoint|nucleotide-excision repair DNA clamp loader activity Rad17 RFC-like complex|nucleus
YGR148C YGR148C RPL24B hom Verified 0.25766781047277 0.398331645462608 no 1826 0.393083909958025 1277 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L24B; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24B has a paralog, RPL24A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YPR123C_d YPR123C YPR123C hom Dubious 0.257015996730954 0.398583212089281 no 1827 0.471593578340229 1551 NA FF Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CTR Unknown Unknown Unknown
YML012C-A_d YML012C-A YML012C-A hom Dubious 0.255353424098301 0.399225070359645 no 1828 0.401461644871117 1334 NA FF Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SEL1 Unknown Unknown Unknown
YER121W_p YER121W YER121W hom Uncharacterized 0.254609284459108 0.399512443756365 no 1829 0.420932423589453 1355 NA Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy biological_process molecular_function cellular_component
YCL005W YCL005W LDB16 hom Verified 0.254522997210744 0.399545769871711 no 1830 0.424128423865978 1411 NA FT MITOCHONDRION Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria biological_process molecular_function mitochondrion|lipid particle
YHR029C YHR029C YHI9 hom Verified 0.253915802078607 0.399780303248621 no 1831 0.406326759663008 1322 NA FT SIGNALING Protein of unknown function; null mutant is defective in unfolded protein response; possibly involved in a membrane regulation metabolic pathway; member of the PhzF superfamily, though most likely not involved in phenazine production endoplasmic reticulum unfolded protein response molecular_function cellular_component
YOL114C_p YOL114C YOL114C hom Uncharacterized 0.253078101938518 0.400103930144233 no 1832 0.414882194102681 1377 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION Putative protein of unknown function with similarity to human ICT1 and prokaryotic factors that may function in translation termination; YOL114C is not an essential gene biological_process molecular_function cellular_component
YKR070W_p YKR070W YKR070W hom Uncharacterized 0.252953179811733 0.400152196925537 no 1833 0.389031918313741 1258 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YIL137C YIL137C TMA108 hom Verified 0.252754093034964 0.400229122222249 no 1834 0.395180502566341 1286 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|PROTEOLYSIS Protein that associates with ribosomes and is involved in ribosome biogenesis; putative metalloprotease ribosome biogenesis molecular_function ribosome|cytoplasm
YJR024C YJR024C MDE1 hom Verified 0.252580602644047 0.400296160467782 no 1835 0.39153042020234 1281 NA FT KETONE METABOLISM|AMINO ACID METABOLISM 5'-methylthioribulose-1-phosphate dehydratase; acts in the methionine salvage pathway; potential Smt3p sumoylation substrate; expression downregulated by caspofungin and deletion mutant is caspofungin resistant L-methionine salvage from methylthioadenosine methylthioribulose 1-phosphate dehydratase activity cytoplasm
YNL220W YNL220W ADE12 hom Verified 0.252491059792916 0.400330761779343 no 1836 0.399072987134586 1320 NA FT NUCLEOTIDE METABOLISM Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence purine nucleotide biosynthetic process DNA replication origin binding|adenylosuccinate synthase activity cytoplasm
YDR321W YDR321W ASP1 hom Verified 0.252174587088874 0.40045306000454 no 1837 0.390961224980985 1305 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Cytosolic L-asparaginase, involved in asparagine catabolism; catalyzes hydrolysis of L-asparagine to aspartic acid and ammonia, has an important role in therapy of acute lymphoblastic leukemia; synthesized constitutively asparagine catabolic process asparaginase activity intracellular
YPR014C_d YPR014C YPR014C hom Dubious 0.252111585804357 0.40047740748845 no 1838 0.372807287284491 1298 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR014C is not an essential gene Unknown Unknown Unknown
YIL127C_p YIL127C RRT14 hom Uncharacterized 0.252095809409963 0.400483504496253 no 1839 0.389743608747027 1294 NA FT NUCLEUS Putative protein of unknown function; identified in a screen for mutants with decreased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis biological_process molecular_function nucleolus
YPR121W YPR121W THI22 hom Verified 0.251698917320513 0.400636896958306 no 1840 0.364331290578008 1220 NA Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis thiamine biosynthetic process phosphomethylpyrimidine kinase activity|hydroxymethylpyrimidine kinase activity cellular_component
YDR360W_d YDR360W OPI7 hom Dubious 0.251595312693266 0.400676941017368 no 1841 0.398476753132714 1310 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene VID21/YDR359C. Unknown Unknown Unknown
YGR263C YGR263C SAY1 hom Verified 0.25092222956296 0.400937118704097 no 1842 0.415778571718335 1404 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Sterol deacetylase; component of the sterol acetylation/deacetylation cycle along with Atf2p; integral membrane protein with active site in the ER lumen; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum response to toxin|sterol metabolic process|sterol deacetylation steryl deacetylase activity integral to membrane|endoplasmic reticulum|endoplasmic reticulum lumen
YER060W-A YER060W-A FCY22 hom Verified 0.249986217295739 0.401299003658559 no 1843 0.375579911711977 1218 NA Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function transmembrane transport nucleobase transmembrane transporter activity integral to membrane
YKL068W-A_p YKL068W-A YKL068W-A hom Uncharacterized 0.249668907031405 0.40142170270798 no 1844 0.433742140557769 1437 NA Putative protein of unknown function; identified by homology to Ashbya gossypii biological_process molecular_function cellular_component
YHR108W YHR108W GGA2 hom Verified 0.249385651033893 0.40153124170311 no 1845 0.39888211233747 1364 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT GOLGI APPARATUS Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|Golgi to vacuole transport|Golgi to endosome transport ubiquitin binding|phosphatidylinositol-4-phosphate binding trans-Golgi network
YHL037C_d YHL037C YHL037C hom Dubious 0.249278239199237 0.401572781362766 no 1846 0.39118944366073 1264 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR014C YLR014C PPR1 hom Verified 0.249219455287292 0.40159551548968 no 1847 0.423654007353024 1383 NA FT TRANSCRIPTION FROM RNA POL II|NUCLEOTIDE METABOLISM NUCLEUS Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of URA1, URA3, URA4, and URA10, which are involved in de novo pyrimidine biosynthesis, in response to pyrimidine starvation; activity may be modulated by interaction with Tup1p positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding RNA polymerase II transcription factor activity|sequence-specific DNA binding|zinc ion binding nucleus
YKL202W_d YKL202W YKL202W hom Dubious 0.247610065026283 0.402218061218366 no 1848 0.375141409469867 1257 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YJR104C YJR104C SOD1 hom Verified 0.247530385194657 0.402248889498612 no 1849 0.458610703925187 1529 NA FF|FT ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS NUCLEUS|MITOCHONDRION Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid cellular copper ion homeostasis|fungal-type cell wall organization|superoxide metabolic process|cellular zinc ion homeostasis|positive regulation of sequence-specific DNA binding transcription factor activity|age-dependent response to reactive oxygen species involved in chronological cell aging superoxide dismutase activity cytosol|mitochondrion|nucleus|mitochondrial intermembrane space
YLR334C_d YLR334C YLR334C hom Dubious 0.247450623808548 0.402279749941416 no 1850 0.382192609577115 1268 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps a stand-alone long terminal repeat sequence whose presence indicates a retrotransposition event occurred here Unknown Unknown Unknown
YFR036W YFR036W CDC26 hom Verified 0.24674774840821 0.402551725466181 no 1851 0.442072382151316 1446 NA FF|FT CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION|PROTEOLYSIS NUCLEUS UBIQUITIN LIGASE COMPLEX Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition chromatin assembly|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination ubiquitin-protein ligase activity anaphase-promoting complex
YBR278W YBR278W DPB3 hom Verified 0.245789476391003 0.402922601919267 no 1852 0.408946275718456 1344 NA FT RESPONSE TO DNA DAMAGE|GENE SILENCING NUCLEUS|CHROMOSOME Third-largest subunit of DNA polymerase II (DNA polymerase epsilon); required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; mRNA abundance peaks at the G1/S boundary of the cell cycle; DPB3 has a paralog, DLS1, that arose from the whole genome duplication DNA-dependent DNA replication|chromatin silencing at telomere double-stranded DNA binding|single-stranded DNA binding|DNA-directed DNA polymerase activity epsilon DNA polymerase complex
YDR461W YDR461W MFA1 hom Verified 0.245714209381378 0.402951735934563 no 1853 0.408039713452467 1345 NA FT SIGNALING PLASMA MEMBRANE Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA2 pheromone-dependent signal transduction involved in conjugation with cellular fusion mating pheromone activity extracellular region
YJR053W YJR053W BFA1 hom Verified 0.245418103641945 0.403066356439348 no 1854 0.385539455415187 1265 NA FT CELL CYCLE|CELL DIVISION CYTOSKELETON Component of the GTPase-activating Bfa1p-Bub2p complex involved in multiple cell cycle checkpoint pathways that control exit from mitosis regulation of exit from mitosis|mitotic cell cycle spindle orientation checkpoint GTPase activator activity spindle pole body
YNL022C_p YNL022C YNL022C hom Uncharacterized 0.244938586530475 0.403251991893586 no 1855 0.393182811611849 1334 NA FT NUCLEUS Putative cytosine 5-methyltransferase, contains seven beta-strand methyltransferase motif similar to NOP2/YNL061W; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; predicted to be involved in ribosome biogenesis biological_process tRNA (cytosine-5-)-methyltransferase activity nucleus
YDR134C YDR134C YDR134C hom pseudogene 0.243575151998867 0.403779937294524 no 1856 0.398703493223236 1323 NA Hypothetical protein; YDR134C has a paralog, CCW12, that arose from the whole genome duplication biological_process molecular_function fungal-type cell wall
YMR226C YMR226C YMR226C hom Verified 0.243482034890172 0.403816000254992 no 1857 0.402645023311017 1326 NA FT OXIDATION-REDUCTION PROCESS NUCLEUS NADP(+)-dependent dehydrogenase; acts on serine, L-allo-threonine, and other 3-hydroxy acids; green fluorescent protein fusion protein localizes to the cytoplasm and nucleus; may interact with ribosomes, based on co-purification experiments metabolic process oxidoreductase activity|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor|carbonyl reductase (NADPH) activity integral to membrane|ribosome|nucleus|cytoplasm
YDR092W YDR092W UBC13 hom Verified 0.242096506494437 0.404352692556831 no 1858 0.41020396314628 1347 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE NUCLEUS Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus postreplication repair|protein monoubiquitination|protein polyubiquitination|free ubiquitin chain polymerization ubiquitin-protein ligase activity ubiquitin conjugating enzyme complex|nucleus|cytoplasm
YNL203C_d YNL203C YNL203C hom Dubious 0.241805658181876 0.404465377202265 no 1859 0.407727023028888 1372 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YEL068C_p YEL068C YEL068C hom Uncharacterized 0.240853204425098 0.40483444598897 no 1860 0.38455643354217 1266 NA Protein of unknown function; expressed at both mRNA and protein levels biological_process molecular_function cellular_component
YCL047C YCL047C POF1 hom Verified 0.240688716834354 0.404898192297002 no 1861 0.41081349127571 1349 NA FT PROTEOLYSIS ATPase involved in the protein quality control and filamentation pathways; interacts physically with Kss1p and suppresses the filamentation defect of a kss1 deletion; also interacts with Ubc7p pseudohyphal growth|ER-associated protein catabolic process|invasive growth in response to glucose limitation ATPase activity cellular_component
YNL055C YNL055C POR1 hom Verified 0.239837530540148 0.40522810539183 no 1862 0.42129638533177 1410 NA FT ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS MITOCHONDRION Mitochondrial porin (voltage-dependent anion channel); outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated; protein abundance increases in response to DNA replication stress; POR1 has a paralog, POR2, that arose from the whole genome duplication DNA transport|mitochondrion organization|apoptotic process|ion transport|cell redox homeostasis voltage-gated anion channel activity mitochondrial outer membrane|mitochondrion|integral to mitochondrial outer membrane
YFR026C YFR026C ULI1 hom Verified 0.238186414419988 0.405868256831518 no 1863 0.408512076254206 1362 NA FT SIGNALING Putative protein of unknown function involved in and induced by the endoplasmic reticulum unfolded protein response endoplasmic reticulum unfolded protein response molecular_function cellular_component
YMR165C YMR165C PAH1 hom Verified 0.238019213664455 0.405933096021878 no 1864 0.399372695638672 1315 NA FT LIPID METABOLISM|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Mg2+-dependent phosphatidate (PA) phosphatase; dephosphorylates PA to yield diacylglycerol; responsible for de novo lipid synthesis and formation of lipid droplets; phosphorylation by Pho80p-Pho85p decreases catalytic activity and alters Pah1p localization and abundance; phosphorylation by protein kinase A decreases catalytic efficiency; dephosphorylation by Nem1p-Spo7p anchors Pah1p to the membrane increasing substrate catalysis; homologous to mammalian lipins 1 and 2 plasmid maintenance|vacuole fusion, non-autophagic|lipid particle organization|aerobic respiration|phospholipid biosynthetic process phosphatidate phosphatase activity cytosol|nuclear membrane|vacuole|cytoplasm|extrinsic to membrane
YPL054W YPL054W LEE1 hom Verified 0.237868042535957 0.4059917212652 no 1865 0.378471057271465 1254 NA Zinc-finger protein of unknown function biological_process molecular_function cellular_component
YML081W YML081W TDA9 hom Verified 0.237281972306456 0.406219023403721 no 1866 0.386101037807872 1269 NA FT NUCLEUS DNA-binding protein, putative transcription factor; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; TDA9 has a paralog, RSF2, that arose from the whole genome duplication biological_process sequence-specific DNA binding nucleus
YJR153W YJR153W PGU1 hom Verified 0.237273631850801 0.406222258403756 no 1867 0.38221988620244 1268 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM Endo-polygalacturonase, pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectins pseudohyphal growth|pectin catabolic process polygalacturonase activity extracellular region
YOR357C YOR357C SNX3 hom Verified 0.237196300013817 0.406252253292307 no 1868 0.405818604978671 1332 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p protein localization|late endosome to Golgi transport phosphatidylinositol-3-phosphate binding cytosol|endosome
YLR190W YLR190W MMR1 hom Verified 0.236562475198988 0.406498117191572 no 1869 0.367575806327813 1208 NA FT CELL CYCLE|CELL DIVISION|MITOCHONDRION ORGANIZATION MITOCHONDRION|SITE OF POLARIZED GROWTH Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p mitochondrion inheritance molecular_function mitochondrial outer membrane|incipient cellular bud site|mitochondrion|cellular bud|cellular bud neck
YOL052C YOL052C SPE2 hom Verified 0.233968831474025 0.407504588006262 no 1870 0.417565989866358 1375 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM NUCLEUS S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically spermidine biosynthetic process|spermine biosynthetic process|pantothenate biosynthetic process adenosylmethionine decarboxylase activity nucleus|cytoplasm
YLL041C YLL041C SDH2 hom Verified 0.233401798620178 0.407724708321925 no 1871 0.398224605681577 1286 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain mitochondrial electron transport, succinate to ubiquinone|cellular respiration|tricarboxylic acid cycle succinate dehydrogenase (ubiquinone) activity mitochondrial respiratory chain complex II|mitochondrion|mitochondrial membrane
YNL297C YNL297C MON2 hom Verified 0.232773885014214 0.407968496339472 no 1872 0.452064034049045 1496 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Peripheral membrane protein with a role in endocytosis and vacuole integrity, interacts with Arl1p and localizes to the endosome; member of the Sec7p family of proteins transport|endocytosis|protein targeting to vacuole|Golgi to endosome transport guanyl-nucleotide exchange factor activity cytosol|endosome|trans-Golgi network|extrinsic to membrane
YBR294W YBR294W SUL1 hom Verified 0.232131118442786 0.408218087942851 no 1873 0.397676637983906 1303 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE High affinity sulfate permease of the SulP anion transporter family; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates sulfate transport|transmembrane transport sulfate transmembrane transporter activity integral to membrane|plasma membrane
YGR154C YGR154C GTO1 hom Verified 0.231624157614826 0.408414971323166 no 1874 0.406572444271671 1340 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS Omega-class glutathione transferase; induced under oxidative stress; putative peroxisomal localization glutathione metabolic process glutathione transferase activity peroxisome
YDR079C-A YDR079C-A TFB5 hom Verified 0.23071802623851 0.408766934197728 no 1875 0.408561650033861 1367 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION NUCLEUS RNA POL II, HOLOENZYME Component of the RNA polymerase II general transcription and DNA repair factor TFIIH; involved in transcription initiation and in nucleotide-excision repair; homolog of Chlamydomonas reinhardtii REX1-S protein involved in DNA repair phosphorylation of RNA polymerase II C-terminal domain|nucleotide-excision repair|transcription from RNA polymerase II promoter core RNA polymerase binding transcription factor activity core TFIIH complex|holo TFIIH complex|nucleus
YPL172C YPL172C COX10 hom Verified 0.230635688440081 0.408798919798917 no 1876 0.428563019949969 1390 NA FT COFACTOR METABOLISM MITOCHONDRION Heme A:farnesyltransferase, catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; human ortholog is associated with mitochondrial disorders heme a biosynthetic process protoheme IX farnesyltransferase activity mitochondrion|integral to membrane
YDL075W YDL075W RPL31A hom Verified 0.230312708617366 0.408924392992334 no 1877 0.422954591459309 1411 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L31A; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31A has a paralog, RPL31B, that arose from the whole genome duplication cytoplasmic translation|regulation of translational fidelity structural constituent of ribosome cytosolic large ribosomal subunit
YGL038C YGL038C OCH1 hom Verified 0.230172007314349 0.408979056421747 no 1878 0.496673557167485 1695 NA FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Mannosyltransferase of the cis-Golgi apparatus, initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins protein N-linked glycosylation alpha-1,6-mannosyltransferase activity|transferase activity, transferring glycosyl groups Golgi cis cisterna
YMR013W-A_d YMR013W-A YMR013W-A hom Dubious 0.230163184839745 0.408982484073147 no 1879 0.393472957221327 1277 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the characterized snoRNA gene snR73 Unknown Unknown Unknown
YDR192C YDR192C NUP42 hom Verified 0.229857727654006 0.409101162635539 no 1880 0.421141767985045 1368 NA FT PROTEIN LOCALIZATION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; interacts with Gle1p poly(A)+ mRNA export from nucleus|NLS-bearing substrate import into nucleus|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|mRNA export from nucleus in response to heat stress|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery nucleocytoplasmic transporter activity|structural constituent of nuclear pore nuclear pore central transport channel|integral to membrane|nuclear pore cytoplasmic filaments|nuclear pore
YDR255C YDR255C RMD5 hom Verified 0.229596942247093 0.409202491571158 no 1881 0.413250118946801 1372 NA FT KETONE METABOLISM|CELL CYCLE|CARBOHYDRATE METABOLISM|PROTEOLYSIS Component of GID Complex that confers ubiquitin ligase (U3) activity; necessary for polyubiquitination and degradation of the gluconeogenic enzyme fructose-1,6-bisphosphatase; forms dimer with Fyv10p that is then recruited to GID Complex by Gid8p; also required for sporulation; conserved protein that has a degenerate RING finger domain negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity cytosol|GID complex
YPL159C YPL159C PET20 hom Verified 0.227920041182689 0.409854201062034 no 1882 0.413937242487172 1367 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Mitochondrial protein, required for respiratory growth under some conditions and for stability of the mitochondrial genome aerobic respiration molecular_function mitochondrion
YCR020C YCR020C PET18 hom Verified 0.227695800868127 0.409941368561598 no 1883 0.427290313236165 1412 NA Protein of unknown function, has weak similarity to proteins involved in thiamin metabolism; expression is induced in the absence of thiamin thiamine metabolic process molecular_function cytosol
YFL033C YFL033C RIM15 hom Verified 0.227183565997385 0.410140503027264 no 1884 0.403461860899148 1339 NA FT CELL CYCLE|SIGNALING|PROTEIN PHOSPHORYLATION|RESPONSE TO OXIDATIVE STRESS NUCLEUS Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase protein phosphorylation|age-dependent response to oxidative stress involved in chronological cell aging|response to stress|regulation of meiosis protein serine/threonine kinase activity|protein kinase activity nucleus|cytoplasm
YOL159C-A YOL159C-A YOL159C-A hom Verified 0.226698783934543 0.410328986390451 no 1885 0.394456820943497 1283 NA FT NUCLEUS Protein of unknown function; overexpression affects endocytic protein trafficking; identified by sequence comparison with hemiascomycetous yeast species biological_process molecular_function nucleus|cytoplasm
YLR390W-A YLR390W-A CCW14 hom Verified 0.225505719822487 0.410792938092881 no 1886 0.40866881297651 1326 NA FT CELL WALL ORG/BIOGENESIS MITOCHONDRION Covalently linked cell wall glycoprotein, present in the inner layer of the cell wall fungal-type cell wall organization structural constituent of cell wall mitochondrion|fungal-type cell wall
YBR098W YBR098W MMS4 hom Verified 0.223352728658622 0.411630496028604 no 1887 0.405323110792499 1353 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p DNA repair|DNA topological change|regulation of reciprocal meiotic recombination|reciprocal meiotic recombination|resolution of meiotic recombination intermediates|response to DNA damage stimulus transcription coactivator activity|endonuclease activity|crossover junction endodeoxyribonuclease activity Holliday junction resolvase complex|nucleus
YLR233C YLR233C EST1 hom Verified 0.22290680856011 0.411804018619318 no 1888 0.336999284045972 1098 NA FT NUCLEUS|CHROMOSOME TLC1 RNA-associated factor involved in telomere length regulation as recruitment subunit of telomerase; has G-quadruplex promoting activity that is required for telomere elongation; possible role in activating telomere-bound Est2p-TLC1-RNA telomere maintenance via telomerase|telomere maintenance|G-quadruplex DNA formation single-stranded DNA binding|RNA binding|telomeric DNA binding nucleolus|nucleus|telomerase holoenzyme complex
YDL179W YDL179W PCL9 hom Verified 0.222443897264013 0.411984171306337 no 1889 0.42072014820319 1378 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION SITE OF POLARIZED GROWTH Cyclin, forms a functional kinase complex with Pho85p cyclin-dependent kinase (Cdk), expressed in late M/early G1 phase, activated by Swi5p regulation of establishment or maintenance of cell polarity|regulation of transcription involved in G1/S phase of mitotic cell cycle cyclin-dependent protein kinase regulator activity cyclin-dependent protein kinase holoenzyme complex|incipient cellular bud site|cellular bud neck
YPR158W YPR158W CUR1 hom Verified 0.222271574137825 0.41205123959535 no 1890 0.432813456511444 1413 NA FT NUCLEUS Sorting factor, central regulator of spatial protein quality control; physically and functionally interacts with chaperones to promote sorting and deposition of misfolded proteins into cytosolic compartments; involved in destabilization of [URE3] prions; CUR1 has a paralog, BTN2, that arose from the whole genome duplication cellular response to stress|protein localization to nucleus chaperone binding nucleus
YAR003W YAR003W SWD1 hom Verified 0.220705383534813 0.412660919686528 no 1891 0.442127497874666 1447 NA FT CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member with similarity to mammalian Rbbp7 histone H3-K4 methylation|telomere maintenance|regulation of transcription, DNA-dependent|chromatin silencing at telomere histone methyltransferase activity (H3-K4 specific) Set1C/COMPASS complex
YIR007W_p YIR007W YIR007W hom Uncharacterized 0.220696026876188 0.412664562642048 no 1892 0.40569066376666 1325 NA FT CARBOHYDRATE METABOLISM Putative glycosidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YIR007W is a non-essential gene biological_process molecular_function cytoplasm
YDR179W-A_p YDR179W-A YDR179W-A hom Uncharacterized 0.220497412456006 0.41274189367738 no 1893 0.418569517933657 1365 NA Putative protein of unknown function biological_process molecular_function cellular_component
YHR156C YHR156C LIN1 hom Verified 0.21981066322724 0.41300930733791 no 1894 0.416573141749883 1376 NA FT NUCLEUS|CHROMOSOME Non-essential component of U5 snRNP; nuclear protein; physically interacts with Irr1p of cohesin complex; may link together proteins involved in chromosome segregation, mRNA splicing and DNA replication biological_process protein binding chromatin|nucleus|U4/U6 x U5 tri-snRNP complex|U5 snRNP
YJL148W YJL148W RPA34 hom Verified 0.218697709004345 0.413442766869685 no 1895 0.352857360749106 1138 NA FT NUCLEUS RNA polymerase I subunit A34.5 transcription elongation from RNA polymerase I promoter|transcription of nuclear large rRNA transcript from RNA polymerase I promoter molecular_function DNA-directed RNA polymerase I complex|nucleolus|nucleus
YKL086W YKL086W SRX1 hom Verified 0.218639997468295 0.413465246521091 no 1896 0.413254217165948 1352 NA FT OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS NUCLEUS Sulfiredoxin; contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxin Tsa1p, which is formed upon exposure to oxidants; conserved in higher eukaryotes; protein abundance increases in response to DNA replication stress cellular response to oxidative stress sulfiredoxin activity nucleus|cytoplasm
YKL027W YKL027W YKL027W hom Verified 0.218160223636175 0.413652137783502 no 1897 0.416552370304359 1363 NA FT MITOCHONDRION Protein of unknown function, localized to the mitochondrial outer membrane biological_process molecular_function mitochondrial outer membrane|mitochondrion
YHR120W YHR120W MSH1 hom Verified 0.217165365202968 0.414039737570441 no 1898 0.386640909813971 1298 NA FT RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION MITOCHONDRION DNA-binding protein of the mitochondria involved in repair of mitochondrial DNA, has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during meiosis DNA repair|mismatch repair|mitochondrial DNA repair|mitochondrion organization|reciprocal meiotic recombination|mitochondrial genome maintenance guanine/thymine mispair binding|dinucleotide insertion or deletion binding|DNA-dependent ATPase activity mitochondrion
YER061C YER061C CEM1 hom Verified 0.21701007416589 0.414100246983562 no 1899 0.426689210838377 1400 NA FT KETONE METABOLISM|LIPID METABOLISM MITOCHONDRION Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration fatty acid biosynthetic process fatty acid synthase activity mitochondrion
YDR010C_d YDR010C YDR010C hom Dubious 0.216920612066847 0.414135106966395 no 1900 0.424762893161519 1385 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YIL076W YIL076W SEC28 hom Verified 0.21683472523388 0.414168574440298 no 1901 0.401317379845363 1314 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth; protein abundance increases in response to DNA replication stress late endosome to vacuole transport via multivesicular body sorting pathway|ER to Golgi vesicle-mediated transport|vesicle coating molecular_function endosome|COPI vesicle coat
YMR272C YMR272C SCS7 hom Verified 0.216108282621421 0.414451671831771 no 1902 0.432081952886529 1443 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Sphingolipid alpha-hydroxylase, functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth inositolphosphoceramide metabolic process fatty acid alpha-hydroxylase activity integral to membrane|endoplasmic reticulum|membrane
YIL073C YIL073C SPO22 hom Verified 0.215531581133521 0.414676446204843 no 1903 0.379678055720971 1257 NA FT CELL CYCLE NUCLEUS|CHROMOSOME Meiosis-specific protein essential for chromosome synapsis, involved in completion of nuclear divisions during meiosis; induced early in meiosis regulation of synaptonemal complex assembly molecular_function condensed nuclear chromosome
YPL145C YPL145C KES1 hom Verified 0.215464139667107 0.414702733923532 no 1904 0.410271786772729 1323 NA FT VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|GOLGI APPARATUS One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication post-Golgi vesicle-mediated transport|positive regulation of phosphatase activity|maintenance of cell polarity|endocytosis|exocytosis|sterol transport phosphatidic acid binding|lipid binding|phosphatidylinositol-4,5-bisphosphate binding|oxysterol binding|sterol transporter activity|phosphatidylinositol-4-phosphate binding Golgi membrane|extrinsic to membrane|cytoplasm
YPR138C YPR138C MEP3 hom Verified 0.215258004423692 0.41478308485978 no 1905 0.413400533772029 1346 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Ammonium permease of high capacity and low affinity; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation ammonia permease nitrogen utilization|ammonium transport ammonium transmembrane transporter activity integral to membrane|plasma membrane
YOR368W YOR368W RAD17 hom Verified 0.2132275513581 0.415574739749158 no 1906 0.421184770263439 1387 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins double-strand break repair|reciprocal meiotic recombination|DNA damage checkpoint double-stranded DNA binding nucleus|checkpoint clamp complex
YGL077C YGL077C HNM1 hom Verified 0.212663206604172 0.415794833570809 no 1907 0.407309699243683 1347 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Choline/ethanolamine transporter; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol choline transport|ethanolamine transport|glycine betaine transport choline transmembrane transporter activity|ethanolamine transmembrane transporter activity integral to membrane|plasma membrane
YLR203C YLR203C MSS51 hom Verified 0.21201313459417 0.41604839366224 no 1908 0.410055164411522 1316 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Specific translational activator for the mitochondrial COX1 mRNA; loosely associated with the matrix face of the mitochondrial inner membrane; influences both COX1 mRNA translation and Cox1p assembly into cytochrome c oxidase; binds to heme B, which may be a mechanism for sensing oxygen levels in order to regulate cytochrome c oxidase biogenesis mitochondrial respiratory chain complex IV biogenesis|positive regulation of mitochondrial translation translation regulator activity extrinsic to mitochondrial inner membrane|mitochondrion
YOR034C YOR034C AKR2 hom Verified 0.212007521139851 0.416050583338158 no 1909 0.403369322358837 1343 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION GOLGI APPARATUS Ankyrin repeat-containing protein; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; possibly involved in constitutive endocytosis of Ste3p; AKR2 has a paralog, AKR1, that arose from the whole genome duplication endocytosis|protein palmitoylation palmitoyltransferase activity integral to membrane|Golgi apparatus
YMR123W YMR123W PKR1 hom Verified 0.211608974691653 0.416206053548913 no 1910 0.446412755787063 1458 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM V-ATPase assembly factor; functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); protein abundance increases in response to DNA replication stress vacuolar proton-transporting V-type ATPase complex assembly molecular_function integral to endoplasmic reticulum membrane
YGR208W YGR208W SER2 hom Verified 0.21135234222618 0.416306171038841 no 1911 0.407774010064088 1351 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source L-serine biosynthetic process phosphoserine phosphatase activity nucleus|cytoplasm
YDL170W YDL170W UGA3 hom Verified 0.210719666641101 0.416553013701461 no 1912 0.41335745718128 1342 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|RESPONSE TO NUTRIENT LEVELS NUCLEUS Transcriptional activator necessary for gamma-aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1, UGA2, UGA4); zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus nitrogen utilization|nitrogen catabolite activation of transcription from RNA polymerase II promoter|gamma-aminobutyric acid catabolic process sequence-specific DNA binding transcription factor recruiting transcription factor activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YJR120W YJR120W YJR120W hom Verified 0.209570997321354 0.417001258864693 no 1913 0.416128284934166 1391 NA FT OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p cellular respiration|sterol transport|mitochondrion organization molecular_function cellular_component
YBR283C YBR283C SSH1 hom Verified 0.208802074860836 0.41730137576686 no 1914 0.37502315491373 1209 NA FT PROTEIN LOCALIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Subunit of the Ssh1 translocon complex; Sec61p homolog involved in co-translational pathway of protein translocation; not essential SRP-dependent cotranslational protein targeting to membrane protein transmembrane transporter activity|signal sequence binding integral to membrane|Ssh1 translocon complex
YOR028C YOR028C CIN5 hom Verified 0.208264390925201 0.417511266968274 no 1915 0.394828986705865 1303 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Basic leucine zipper (bZIP) transcription factor of the yAP-1 family; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; mediates pleiotropic drug resistance and salt tolerance; nuclearly localized under oxidative stress and sequestered in the cytoplasm by Lot6p under reducing conditions; CIN5 has a paralog, YAP6, that arose from the whole genome duplication hyperosmotic salinity response|response to drug|hyperosmotic response|regulation of transcription from RNA polymerase II promoter repressing transcription factor binding|sequence-specific DNA binding nucleus|cytoplasm
YOL093W YOL093W TRM10 hom Verified 0.207993861534324 0.417616880166172 no 1916 0.435113096532626 1449 NA FT RNA PROCESSING NUCLEUS tRNA methyltransferase; methylates the N-1 position of guanosine in tRNAs; protein abundance increases in response to DNA replication stress tRNA methylation tRNA (guanine) methyltransferase activity nucleus|cytoplasm
YNL160W YNL160W YGP1 hom Verified 0.207651860280708 0.41775040409367 no 1917 0.422278745593956 1399 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p cell wall assembly molecular_function extracellular region
YMR065W YMR065W KAR5 hom Verified 0.207380457003755 0.417856371950152 no 1918 0.417022619374038 1394 NA FT ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION Protein required for nuclear membrane fusion during karyogamy, localizes to the membrane with a soluble portion in the endoplasmic reticulum lumen, may form a complex with Jem1p and Kar2p; expression of the gene is regulated by pheromone karyogamy involved in conjugation with cellular fusion molecular_function mitochondrion|endoplasmic reticulum membrane
YOL048C YOL048C RRT8 hom Verified 0.207355608312401 0.417866074277657 no 1919 0.412314180107503 1339 NA Protein of unknown function; identified in a screen for mutants with increased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to lipid particles; protein abundance increases in response to DNA replication stress biological_process molecular_function integral to membrane|lipid particle
YOL091W YOL091W SPO21 hom Verified 0.205322730173677 0.418659993122727 no 1920 0.403729721685186 1316 NA FT CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION CYTOSKELETON Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation ascospore wall assembly|meiosis structural molecule activity spindle pole body
YEL007W YEL007W MIT1 hom Verified 0.204293624171307 0.419062026042506 no 1921 0.40375193100256 1328 NA FT NUCLEUS Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1 biological_process molecular_function nucleus|cytoplasm
YMR170C YMR170C ALD2 hom Verified 0.203913711995072 0.419210464792946 no 1922 0.413106087972145 1352 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p cellular aldehyde metabolic process|beta-alanine biosynthetic process|polyamine catabolic process aldehyde dehydrogenase (NAD) activity cytoplasm
YJL043W_p YJL043W YJL043W hom Uncharacterized 0.202760236817871 0.419661219366648 no 1923 0.384331134689524 1299 NA FT MITOCHONDRION Putative protein of unknown function; YJL043W is a non-essential gene biological_process molecular_function mitochondrion|cytoplasm
YMR156C YMR156C TPP1 hom Verified 0.202726940683766 0.41967423238519 no 1924 0.420247578154801 1385 NA FT RESPONSE TO DNA DAMAGE NUCLEUS DNA 3'-phosphatase; functions in repair of endogenous damage of double-stranded DNA, activity is specific for removal of 3' phosphates at strand breaks; similar to the l-2-haloacid dehalogenase superfamily; homolog of human polynucleotide kinase/3′-phosphatase DNA repair polynucleotide 3'-phosphatase activity cellular_component
YAL002W YAL002W VPS8 hom Verified 0.202285325129256 0.419846835842547 no 1925 0.415754255423547 1364 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT GOLGI APPARATUS Membrane-binding component of the CORVET complex; involved in endosomal vesicle tethering and fusion in the endosome to vacuole protein targeting pathway; interacts with Vps21p; contains RING finger motif late endosome to vacuole transport via multivesicular body sorting pathway|protein targeting to vacuole GTPase binding|protein anchor late endosome|membrane|CORVET complex
YDR210W_p YDR210W YDR210W hom Uncharacterized 0.201547892957846 0.42013509225342 no 1926 0.386064242660344 1287 NA FT PLASMA MEMBRANE Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery biological_process molecular_function cellular_component
YGR206W YGR206W MVB12 hom Verified 0.200111477131845 0.420696698728985 no 1927 0.41097564740174 1347 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|VACUOLAR TRANSPORT ESCRT-I subunit required to stabilize oligomers of the ESCRT-I core complex (Stp22p, Vps28p, Srn2p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; deletion mutant is sensitive to rapamycin and nystatin negative regulation of protein complex assembly|protein targeting to vacuole|endosome transport via multivesicular body sorting pathway ubiquitin binding cytosol|endosome|ESCRT I complex
YGR122C-A_d YGR122C-A YGR122C-A hom Dubious 0.199143653265779 0.421075187331851 no 1928 0.423620873710867 1391 NA Dubious open reading frame unlikely to encode a functional protein, similar to YLR334C and YOL106W Unknown Unknown Unknown
YHL040C YHL040C ARN1 hom Verified 0.19869950728886 0.421248904732833 no 1929 0.404770526136946 1323 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE ARN family transporter for siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores; protein increases in abundance and relocalizes to the vacuole upon DNA replication stress siderophore transport siderophore transmembrane transporter activity endosome|integral to membrane|plasma membrane|cytoplasmic membrane-bounded vesicle
YAL014C YAL014C SYN8 hom Verified 0.198061696415498 0.421498396476113 no 1930 0.393813443271376 1293 NA FT PROTEIN LOCALIZATION Endosomal SNARE related to mammalian syntaxin 8 transport SNAP receptor activity endosome
YDR351W YDR351W SBE2 hom Verified 0.198046748361672 0.421504244067465 no 1931 0.422016262366049 1396 NA FT PROTEIN LOCALIZATION|CELL WALL ORG/BIOGENESIS GOLGI APPARATUS Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth fungal-type cell wall organization molecular_function Golgi apparatus
YMR027W_p YMR027W YMR027W hom Uncharacterized 0.197031291627654 0.421901525277603 no 1932 0.416060709291056 1395 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR027W is not an essential gene biological_process molecular_function nucleus|cytoplasm
YMR015C YMR015C ERG5 hom Verified 0.196698944080775 0.422031568226807 no 1933 0.441045767754173 1465 NA FF|FT LIPID METABOLISM|OXIDATION-REDUCTION PROCESS ENDOPLASMIC RETICULUM C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs ergosterol biosynthetic process C-22 sterol desaturase activity endoplasmic reticulum
YLR112W_d YLR112W YLR112W hom Dubious 0.196452834018108 0.422127873133473 no 1934 0.414388362221271 1336 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR453C YDR453C TSA2 hom Verified 0.196127832983807 0.422255055864565 no 1935 0.418640078498756 1390 NA FT OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants; protein abundance increases in response to DNA replication stress cellular response to oxidative stress|cell redox homeostasis peroxiredoxin activity|thioredoxin peroxidase activity cytoplasm
YLR119W YLR119W SRN2 hom Verified 0.195887946727395 0.42234893581072 no 1936 0.425499121412524 1402 NA FT PROTEIN LOCALIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus protein targeting to membrane|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein targeting to vacuole protein binding endosome|ESCRT I complex
YLR300W YLR300W EXG1 hom Verified 0.195727358631163 0.422411784735395 no 1937 0.411500734817286 1340 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM Major exo-1,3-beta-glucanase of the cell wall, involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes fungal-type cell wall organization|cellular glucan metabolic process glucan exo-1,3-beta-glucosidase activity extracellular region|fungal-type cell wall
YKL085W YKL085W MDH1 hom Verified 0.19555594425466 0.4224788728915 no 1938 0.425818799392462 1382 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated chronological cell aging|replicative cell aging|tricarboxylic acid cycle|aerobic respiration L-malate dehydrogenase activity|mRNA binding mitochondrion|mitochondrial matrix
YPL241C YPL241C CIN2 hom Verified 0.195524930071387 0.422491011462398 no 1939 0.421655449728561 1399 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS CYTOSKELETON GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2 protein folding|tubulin complex assembly|tubulin complex biogenesis GTPase activator activity cellular_component
YBR282W YBR282W MRPL27 hom Verified 0.195115179486278 0.422651389721383 no 1940 0.422846262965811 1410 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit; homolog of human Bcl-2 interacting protein BMRP mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YNR001C YNR001C CIT1 hom Verified 0.194639308017378 0.422837664089103 no 1941 0.43182137467667 1433 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein; CIT1 has a paralog, CIT2, that arose from the whole genome duplication glutamate biosynthetic process|tricarboxylic acid cycle|acetyl-CoA catabolic process|citrate metabolic process citrate (Si)-synthase activity mitochondrion
YIR026C YIR026C YVH1 hom Verified 0.194453811447791 0.422910279245987 no 1942 0.426597924023294 1420 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RIBOSOME BIOGENESIS|SIGNALING|CELL WALL ORG/BIOGENESIS NUCLEUS Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases meiosis|ascospore wall assembly|ribosomal large subunit assembly|cAMP-mediated signaling|protein dephosphorylation protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity nucleus|preribosome, large subunit precursor|cytoplasm
YOR177C YOR177C MPC54 hom Verified 0.193221344392309 0.423392811650581 no 1943 0.431514245623689 1432 NA FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION NUCLEUS|CYTOSKELETON Component of the meiotic outer plaque, a membrane-organizing center which is assembled on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; potential Cdc28p substrate ascospore wall assembly|vesicle docking structural molecule activity spindle pole body
YFL023W YFL023W BUD27 hom Verified 0.192183161916342 0.423799367450351 no 1944 0.420561109697274 1396 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION RIBOSOME Unconventional prefoldin protein involved in translation initiation; mutants have inappropriate expression of nutrient sensitive genes due to translational derepression of Gcn4p transcription factor; diploid mutants show random budding; ortholog of human URI/RMP formation of translation preinitiation complex molecular_function cytosolic ribosome|cytoplasm
YBR056W-A_p YBR056W-A YBR056W-A hom Uncharacterized 0.19070965610101 0.424376536535056 no 1945 0.451512207934754 1491 NA Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the dubious ORF YBR056C-B biological_process molecular_function cellular_component
YLR402W_d YLR402W YLR402W hom Dubious 0.190546792951169 0.424440339660824 no 1946 0.428350988037274 1426 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YBR293W YBR293W VBA2 hom Verified 0.189206604422097 0.424965445788801 no 1947 0.42630326032302 1433 NA Permease of basic amino acids in the vacuolar membrane basic amino acid transport|transmembrane transport basic amino acid transmembrane transporter activity|drug transmembrane transporter activity fungal-type vacuole membrane|integral to membrane
YER156C_p YER156C YER156C hom Uncharacterized 0.189152418734691 0.424986679367435 no 1948 0.391302351627847 1281 NA FT NUCLEUS Putative protein of unknown function; interacts with Hsp82p and copurifies with Ipl1p; expression is copper responsive and downregulated in strains deleted for MAC1, a copper-responsive transcription factor; similarity to mammalian MYG1 biological_process molecular_function nucleus|cytoplasm
YJL047C YJL047C RTT101 hom Verified 0.188422911240464 0.425272570389134 no 1949 0.437072674835601 1431 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEOLYSIS NUCLEUS UBIQUITIN LIGASE COMPLEX Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex with a role in anaphase progression; implicated in Mms22-dependent DNA repair; involved with Mms1p in nonfunctional rRNA decay; modified by the ubiquitin-like protein, Rub1p replication fork processing|negative regulation of transposition, RNA-mediated|regulation of mitosis|nonfunctional rRNA decay|ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity Cul8-RING ubiquitin ligase complex|nucleus|cytoplasm
YPR047W YPR047W MSF1 hom Verified 0.187675809974154 0.42556539707064 no 1950 0.4540678187822 1524 NA FT KETONE METABOLISM|RNA PROCESSING|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial phenylalanyl-tRNA synthetase, active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase phenylalanyl-tRNA aminoacylation|mitochondrial phenylalanyl-tRNA aminoacylation phenylalanine-tRNA ligase activity mitochondrion
YKR100C YKR100C SKG1 hom Verified 0.187556315692751 0.425612236721675 no 1951 0.430844744411804 1428 NA FT CELL WALL ORG/BIOGENESIS SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Transmembrane protein with a role in cell wall polymer composition; localizes on the inner surface of the plasma membrane at the bud and in the daughter cell fungal-type cell wall organization molecular_function incipient cellular bud site|cellular bud|cellular bud tip
YKL016C YKL016C ATP7 hom Verified 0.187512222605997 0.425629520699289 no 1952 0.430329165496498 1434 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS MITOCHONDRION Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis protein complex assembly|ATP synthesis coupled proton transport hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism mitochondrion|mitochondrial proton-transporting ATP synthase, stator stalk|integral to membrane|mitochondrial proton-transporting ATP synthase complex
YGR019W YGR019W UGA1 hom Verified 0.187474742037492 0.425644212758958 no 1953 0.422432979582155 1406 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Gamma-aminobutyrate (GABA) transaminase; also known as 4-aminobutyrate aminotransferase; involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization; protein abundance increases in response to DNA replication stress nitrogen utilization|gamma-aminobutyric acid catabolic process 4-aminobutyrate transaminase activity intracellular
YJL187C YJL187C SWE1 hom Verified 0.187307288521471 0.425709854354003 no 1954 0.412463745905145 1350 NA FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION NUCLEUS|SITE OF POLARIZED GROWTH Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate negative regulation of spindle pole body separation|G2/M transition size control checkpoint|protein phosphorylation|re-entry into mitotic cell cycle|G2/M transition of mitotic cell cycle|cell shape checkpoint|regulation of cyclin-dependent protein kinase activity|regulation of cell size|regulation of meiosis protein tyrosine kinase activity|protein kinase activity nucleus|cellular bud neck
YGR183C YGR183C QCR9 hom Verified 0.187084098513479 0.425797347793503 no 1955 0.429541077837428 1403 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex iron-sulfur cluster assembly|mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration ubiquinol-cytochrome-c reductase activity mitochondrion|integral to membrane|mitochondrial respiratory chain complex III
YNL121C YNL121C TOM70 hom Verified 0.186592590466525 0.425990038334065 no 1956 0.440498470259685 1443 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Component of the TOM (translocase of outer membrane) complex; involved in the recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins; TOM70 has a paralog, TOM71, that arose from the whole genome duplication protein import into mitochondrial matrix|protein import into mitochondrial inner membrane mitochondrion targeting sequence binding|protein channel activity mitochondrial outer membrane|mitochondrion|integral to membrane|integral to mitochondrial outer membrane|mitochondrial outer membrane translocase complex
YBR151W YBR151W APD1 hom Verified 0.186444998786809 0.426047903546102 no 1957 0.423530787039599 1408 NA FT NUCLEUS Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus biological_process molecular_function nucleus|cytoplasm
YGR080W YGR080W TWF1 hom Verified 0.185778707460125 0.426309151413547 no 1958 0.423669280485206 1414 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Twinfilin, highly conserved actin monomer-sequestering protein involved in regulation of the cortical actin cytoskeleton, composed of two cofilin-like regions, localizes actin monomers to sites of rapid filament assembly bipolar cellular bud site selection|actin polymerization or depolymerization|sequestering of actin monomers actin monomer binding mating projection tip|actin cortical patch
YCR100C_p YCR100C YCR100C hom Uncharacterized 0.185373623799561 0.426467997515085 no 1959 0.444663751717857 1441 NA Putative protein of unknown function biological_process molecular_function integral to membrane
YPL053C YPL053C KTR6 hom Verified 0.185241636241164 0.42651975658448 no 1960 0.430521372207479 1428 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM Probable mannosylphosphate transferase; involved in the synthesis of core oligosaccharides in protein glycosylation pathway; member of the KRE2/MNT1 mannosyltransferase family; KTR6 has a paralog, KRE2, that arose from the whole genome duplication fungal-type cell wall organization|protein N-linked glycosylation mannosylphosphate transferase activity membrane
YOR216C YOR216C RUD3 hom Verified 0.183155138337663 0.427338146640339 no 1961 0.429157720573235 1419 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT GOLGI APPARATUS Golgi matrix protein involved in the structural organization of the cis-Golgi; interacts genetically with COG3 and USO1 ER to Golgi vesicle-mediated transport molecular_function Golgi apparatus
YLR041W_d YLR041W YLR041W hom Dubious 0.18294289044243 0.427421414522193 no 1962 0.420260157214372 1397 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YLR040C Unknown Unknown Unknown
YER028C YER028C MIG3 hom Verified 0.182769107960252 0.427489594280523 no 1963 0.425388983767422 1420 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Transcriptional regulator; partially nonfunctional in S288C strains but has a major role in catabolite repression and ethanol response in some other strains; involved in response to toxic agents; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes; MIG3 has a paralog, MIG2, that arose from the whole genome duplication cellular response to UV|negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|response to DNA damage stimulus RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding nuclear chromatin
YPL168W_p YPL168W YPL168W hom Uncharacterized 0.182705685771504 0.427514477129474 no 1964 0.429372446677705 1438 NA FT MITOCHONDRION Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; expression may be cell cycle-regulated biological_process molecular_function mitochondrion
YOR290C YOR290C SNF2 hom Verified 0.182669487104042 0.427528679322588 no 1965 0.464390481448638 1539 NA FF|FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS NUCLEUS RSC COMPLEX Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p cellular alcohol catabolic process|ATP-dependent chromatin remodeling|double-strand break repair|strand invasion|positive regulation of mating type switching|sucrose catabolic process|positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation|nucleosome mobilization|chromatin remodeling|DNA-dependent DNA replication|positive regulation of transcription from RNA polymerase II promoter histone acetyl-lysine binding|RNA polymerase II activating transcription factor binding|DNA-dependent ATPase activity|nucleosomal DNA binding SWI/SNF complex|nucleus
YDR194W-A_p YDR194W-A YDR194W-A hom Uncharacterized 0.18255196337574 0.427574789255163 no 1966 0.46011895003883 1523 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YDR032C YDR032C PST2 hom Verified 0.181872135510485 0.427841536206043 no 1967 0.407198336888327 1351 NA FT OXIDATION-REDUCTION PROCESS MITOCHONDRION Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication biological_process molecular_function mitochondrion|membrane raft|plasma membrane|cytoplasm
YEL045C_d YEL045C YEL045C hom Dubious 0.1813645072801 0.428040737969696 no 1968 0.444963690664055 1443 NA Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; deletion gives MMS sensitivity, growth defect under alkaline conditions, less than optimal growth upon citric acid stress Unknown Unknown Unknown
YAR030C_d YAR030C YAR030C hom Dubious 0.181044139266485 0.428166465151642 no 1969 0.427801951719991 1410 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YAR029W and the verified gene PRM9 Unknown Unknown Unknown
YGR079W_p YGR079W YGR079W hom Uncharacterized 0.180597865756771 0.428341615608117 no 1970 0.4458952723589 1485 NA Putative protein of unknown function; YGR079W is not an essential gene biological_process molecular_function cellular_component
YGR241C YGR241C YAP1802 hom Verified 0.179528175260561 0.428761498021827 no 1971 0.435481747828459 1445 NA FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1802 has a paralog, YAP1801, that arose from the whole genome duplication endocytosis clathrin binding actin cortical patch
YCL011C YCL011C GBP2 hom Verified 0.178983468959835 0.42897534097493 no 1972 0.444248270316179 1470 NA FT RNA LOCALIZATION NUCLEUS|CHROMOSOME Poly(A+) RNA-binding protein; involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Npl3p; also binds single-stranded telomeric repeat sequence in vitro; GBP2 has a paralog, HRB1, that arose from the whole genome duplication poly(A)+ mRNA export from nucleus|telomere maintenance RNA binding|telomeric DNA binding nucleus|cytoplasmic stress granule
YGR150C YGR150C CCM1 hom Verified 0.178689272079926 0.42909084662445 no 1973 0.43126778390694 1401 NA FT RNA PROCESSING|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial 15s rRNA-binding protein; required for intron removal of COB and COX1 pre-mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport rRNA metabolic process|mitochondrial RNA processing|mitochondrial genome maintenance rRNA binding mitochondrion
YDR433W_d YDR433W YDR433W hom Dubious 0.178472739411135 0.429175864140656 no 1974 0.433588108872309 1437 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YML096W_p YML096W YML096W hom Uncharacterized 0.178156750272564 0.429299937280607 no 1975 0.424373982217404 1401 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Putative protein of unknown function with similarity to asparagine synthetases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YML096W is not an essential gene and partially overlaps the verified gene RAD10 biological_process molecular_function cytoplasm
YFR009W YFR009W GCN20 hom Verified 0.176934733955317 0.429779827637087 no 1976 0.443773718158524 1468 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|NUCLEOTIDE METABOLISM RIBOSOME Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA regulation of translational elongation ATPase activity cytosol|cytosolic ribosome
YGL215W YGL215W CLG1 hom Verified 0.176883970623971 0.429799764835968 no 1977 0.44105901333325 1434 NA FT CELL CYCLE|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS Cyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2 positive regulation of macroautophagy cyclin-dependent protein kinase regulator activity cyclin-dependent protein kinase holoenzyme complex
YIR035C_p YIR035C YIR035C hom Uncharacterized 0.176643288826071 0.429894294576014 no 1978 0.410398601169146 1341 NA FT OXIDATION-REDUCTION PROCESS Putative cytoplasmic short-chain dehydrogenase/reductase biological_process molecular_function integral to membrane|cytoplasm
YER066C-A_d YER066C-A YER066C-A hom Dubious 0.174713386155932 0.430652424464581 no 1979 0.420287787576167 1393 NA Dubious open reading frame unlikely to encode a protein, partially overlaps uncharacterized ORF YER067W Unknown Unknown Unknown
YMR127C YMR127C SAS2 hom Verified 0.174178768926017 0.430862485213825 no 1980 0.424625660605304 1392 NA FT CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME HISTONE ACETYLTRANSFERASE Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family histone acetylation|histone exchange|chromatin silencing at telomere acetyltransferase activity|histone acetyltransferase activity nuclear chromatin|SAS acetyltransferase complex|nuclear chromosome, telomeric region
YGR139W_d YGR139W YGR139W hom Dubious 0.173801984591348 0.431010542327516 no 1981 0.418648099331914 1385 NA Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR318W YLR318W EST2 hom Verified 0.173767952069074 0.431023915858637 no 1982 0.427926384259004 1419 NA FT NUCLEUS|CHROMOSOME Reverse transcriptase subunit of the telomerase holoenzyme, essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia telomere maintenance via telomerase|replicative cell aging telomerase activity|telomeric template RNA reverse transcriptase activity|telomeric DNA binding telomerase catalytic core complex|nucleolus|nucleus|telomerase holoenzyme complex
YPR128C YPR128C ANT1 hom Verified 0.173070675135828 0.431297937468546 no 1983 0.426279626196979 1426 NA FT KETONE METABOLISM|LIPID METABOLISM|ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|PEROXISOME ORGANIZATION Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation ATP transport|fatty acid beta-oxidation|peroxisome organization adenine nucleotide transmembrane transporter activity integral to membrane|cytoplasm|integral to peroxisomal membrane
YKL166C YKL166C TPK3 hom Verified 0.172537121528668 0.431507640083827 no 1984 0.423078362765471 1382 NA FT SIGNALING|MITOCHONDRION ORGANIZATION|PROTEIN PHOSPHORYLATION NUCLEUS cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication protein phosphorylation|mitochondrion organization|Ras protein signal transduction cAMP-dependent protein kinase activity|protein kinase activity cAMP-dependent protein kinase complex|nucleus|cytoplasm
YHR199C YHR199C AIM46 hom Verified 0.171174161146756 0.432043412018439 no 1985 0.493265886246819 1705 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss biological_process molecular_function mitochondrion
YGL081W_p YGL081W YGL081W hom Uncharacterized 0.170729656278971 0.432218171421322 no 1986 0.430809362340838 1414 NA Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis biological_process molecular_function cellular_component
YGL154C YGL154C LYS5 hom Verified 0.170232583904577 0.432413613720045 no 1987 0.421449751193556 1375 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Phosphopantetheinyl transferase involved in lysine biosynthesis; converts inactive apo-form of Lys2p (alpha-aminoadipate reductase) into catalytically active holo-form by posttranslational addition of phosphopantetheine lysine biosynthetic process via aminoadipic acid|protein-cofactor linkage holo-[acyl-carrier-protein] synthase activity cytoplasm
YGR092W YGR092W DBF2 hom Verified 0.168207107709917 0.433210174736708 no 1988 0.487264298690391 1632 NA FF|FT CELL CYCLE|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS SITE OF POLARIZED GROWTH|CYTOSKELETON Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; phosphorylates Chs2p to regulate primary septum formation and Hof1p to regulate cytokinesis nuclear division|protein phosphorylation|vacuolar acidification protein serine/threonine kinase activity|protein kinase activity spindle pole body|cellular bud neck
YOR111W_p YOR111W YOR111W hom Uncharacterized 0.168122314774988 0.433243527279205 no 1989 0.421515665354535 1397 NA Putative protein of unknown function biological_process molecular_function cellular_component
YER045C YER045C ACA1 hom Verified 0.168041838865234 0.433275182198238 no 1990 0.430692527541264 1425 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS ATF/CREB family basic leucine zipper (bZIP) transcription factor; binds as a homodimer to the ATF/CREB consensus sequence TGACGTCA; important for carbon source utilization; target genes include GRE2 and COS8; ACA1 has a paralog, CST6, that arose from the whole genome duplication positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YLR124W_d YLR124W YLR124W hom Dubious 0.167829730600621 0.433358616296471 no 1991 0.431312896130786 1442 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YEL008W_d YEL008W YEL008W hom Dubious 0.167220487481211 0.433598282352116 no 1992 0.428200057797001 1370 NA Hypothetical protein predicted to be involved in metabolism Unknown Unknown Unknown
YGL217C_d YGL217C YGL217C hom Dubious 0.166662038007136 0.433817988488291 no 1993 0.430930812717228 1418 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF KIP3/YGL216W Unknown Unknown Unknown
YKL003C YKL003C MRP17 hom Verified 0.165340262553382 0.434338084981177 no 1994 0.437317251692531 1454 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YNL275W YNL275W BOR1 hom Verified 0.16431332060681 0.434742247943847 no 1995 0.425443818212002 1415 NA FT PROTEIN LOCALIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT PLASMA MEMBRANE Boron efflux transporter of the plasma membrane; binds HCO3-, I-, Br-, NO3- and Cl-; has similarity to the characterized boron efflux transporter A. thaliana BOR1 borate transport|protein targeting to vacuole borate efflux transmembrane transporter activity integral to membrane|plasma membrane|fungal-type vacuole
YBR235W YBR235W VHC1 hom Verified 0.163125362277514 0.435209865521985 no 1996 0.443086328700665 1441 NA Vacuolar membrane cation-chloride cotransporter (CCC); likely mediates K+ and Cl- cotransport into the vacuole; has a role in potassium homeostasis and salt tolerance; similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family transmembrane transport ion transmembrane transporter activity integral to membrane
YLR260W YLR260W LCB5 hom Verified 0.162208829938815 0.435570703301205 no 1997 0.446053771430378 1482 NA FT LIPID METABOLISM|SIGNALING|PROTEIN PHOSPHORYLATION ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules response to heat|calcium-mediated signaling|sphingolipid metabolic process D-erythro-sphingosine kinase activity Golgi apparatus|membrane
YDR457W YDR457W TOM1 hom Verified 0.160580502115949 0.436211906321929 no 1998 0.41258237431885 1359 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|PROTEOLYSIS|RNA LOCALIZATION NUCLEUS E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones; interacts with Dia2p and is required for Dia2p degradation; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|mitosis|nucleocytoplasmic transport|nucleus organization|cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|regulation of cell size|protein ubiquitination ubiquitin-protein ligase activity integral to membrane|nucleolus|nucleus
YML034C-A_d YML034C-A YML034C-A hom Dubious 0.160571542871105 0.436215434759223 no 1999 0.457308957844651 1519 NA Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGL152C_d YGL152C YGL152C hom Dubious 0.160127995231296 0.436390124352875 no 2000 0.446809001311327 1493 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PEX14/YGL153W Unknown Unknown Unknown
YNL292W YNL292W PUS4 hom Verified 0.159381231311483 0.436684262567127 no 2001 0.437446622607548 1446 NA FT RNA PROCESSING NUCLEUS|MITOCHONDRION Pseudouridine synthase, catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs; PUS4 overexpression leads to translational derepression of GCN4 (Gcd- phenotype) tRNA modification pseudouridine synthase activity mitochondrion|nucleus
YDR519W YDR519W FPR2 hom Verified 0.159262585544525 0.436730998440512 no 2002 0.447984682868524 1469 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase); binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking; relocalizes from nucleus to vacuole upon DNA replication stress biological_process FK506 binding|peptidyl-prolyl cis-trans isomerase activity endoplasmic reticulum membrane
YHL019C YHL019C APM2 hom Verified 0.159045709986167 0.436816430391893 no 2003 0.437774503887438 1447 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport Golgi to vacuole transport|vesicle-mediated transport clathrin binding AP-1 adaptor complex
YBR068C YBR068C BAP2 hom Verified 0.15838640419381 0.437076163217133 no 2004 0.438199893445747 1425 NA FT PLASMA MEMBRANE High-affinity leucine permease; functions as a branched-chain amino acid permease involved in uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains; BAP2 has a paralog, BAP3, that arose from the whole genome duplication amino acid transport|transmembrane transport amino acid transmembrane transporter activity integral to membrane|plasma membrane
YDR345C YDR345C HXT3 hom Verified 0.157934997714634 0.437254009975714 no 2005 0.461747643468509 1520 NA FT PLASMA MEMBRANE Low affinity glucose transporter of the major facilitator superfamily; expression is induced in low or high glucose conditions; HXT3 has a paralog, HXT5, that arose from the whole genome duplication hexose transport|transmembrane transport mannose transmembrane transporter activity|fructose transmembrane transporter activity|glucose transmembrane transporter activity integral to membrane|plasma membrane
YAR042W YAR042W SWH1 hom Verified 0.157707735259142 0.437343552461488 no 2006 0.435953512669465 1457 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats; localizes to the Golgi and the nucleus-vacuole junction endocytosis|maintenance of cell polarity|exocytosis|sterol transport lipid binding|oxysterol binding|1-phosphatidylinositol binding|sterol transporter activity nuclear envelope|endoplasmic reticulum|Golgi trans cisterna|early endosome
YPL084W YPL084W BRO1 hom Verified 0.157341452973655 0.437487876172595 no 2007 0.444090482561861 1453 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes protein deubiquitination|vacuolar transport|protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|response to nutrient|ubiquitin-dependent protein catabolic process ubiquitin-specific protease activity endosome|cytoplasm
YGR058W YGR058W PEF1 hom Verified 0.15694672729765 0.437643416550117 no 2008 0.434593245584853 1452 NA FT CELL CYCLE|CELL DIVISION NUCLEUS|SITE OF POLARIZED GROWTH Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly bipolar cellular bud site selection|regulation of COPII vesicle coating|axial cellular bud site selection zinc ion binding|calcium ion binding cytosol|site of polarized growth|nucleus|cellular bud neck|cytoplasm
YHL047C YHL047C ARN2 hom Verified 0.156312807535256 0.43789323073902 no 2009 0.440901071824561 1461 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS|COFACTOR METABOLISM PLASMA MEMBRANE Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C cellular iron ion homeostasis|siderophore transport|siderophore metabolic process siderophore transmembrane transporter activity endosome|integral to membrane|cytoplasmic membrane-bounded vesicle|plasma membrane
YMR138W YMR138W CIN4 hom Verified 0.154904727567217 0.438448213289404 no 2010 0.440810191704132 1482 NA FT SIGNALING GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; regulated by the GTPase-activating protein, Cin2p, the human retinitis pigmentosa 2 (RP2) homolog protein folding|tubulin complex assembly|tubulin complex biogenesis GTP binding cytoplasm
YHR117W YHR117W TOM71 hom Verified 0.154571238707276 0.438579672813394 no 2011 0.440158164860342 1452 NA FT MITOCHONDRION Mitochondrial outer membrane protein; probable minor component of the TOM (translocase of outer membrane) complex responsible for recognition and import of mitochondrially directed proteins; TOM71 has a paralog, TOM70, that arose from the whole genome duplication biological_process protein transporter activity mitochondrial outer membrane|mitochondrion|integral to membrane|integral to mitochondrial outer membrane
YMR147W_p YMR147W YMR147W hom Uncharacterized 0.154491960939617 0.438610924682657 no 2012 0.427797507033492 1391 NA Putative protein of unknown function biological_process molecular_function cellular_component
YJR095W YJR095W SFC1 hom Verified 0.153895927915985 0.438845897453906 no 2013 0.431269809273385 1422 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization succinate transport|fumarate transport succinate:fumarate antiporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YDR492W YDR492W IZH1 hom Verified 0.153568661693813 0.438974924059493 no 2014 0.436979699268372 1453 NA FT LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc response to zinc ion|cellular zinc ion homeostasis|cellular lipid metabolic process metal ion binding integral to membrane|endoplasmic reticulum|membrane
YOL017W YOL017W ESC8 hom Verified 0.15306076775195 0.439175177027099 no 2015 0.457386105179718 1511 NA FT GENE SILENCING NUCLEUS Protein involved in telomeric and mating-type locus silencing; interacts with Sir2p and also interacts with Gal11p, which is a component of the RNA pol II mediator complex; ESC8 has a paralog, IOC3, that arose from the whole genome duplication chromatin silencing molecular_function nucleus
YHR159W_p YHR159W TDA11 hom Uncharacterized 0.152465909440708 0.439409738190452 no 2016 0.448325211573345 1459 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; potential Cdc28p substrate; null mutant is sensitive to expression of the top1-T722A allele biological_process molecular_function cytoplasm
YCR020W-B YCR020W-B HTL1 hom Verified 0.151620014779462 0.439743323203469 no 2017 0.449901707446047 1491 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS RSC COMPLEX Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance regulation of cell cycle|nucleosome disassembly|response to DNA damage stimulus|chromatin remodeling|transcription elongation from RNA polymerase II promoter chromatin binding RSC complex
YGL260W_p YGL260W YGL260W hom Uncharacterized 0.15148767464881 0.439795516420159 no 2018 0.439618998651739 1463 NA Putative protein of unknown function; transcription is significantly increased in a NAP1 deletion background; deletion mutant has increased accumulation of nickel and selenium biological_process molecular_function cellular_component
YHL017W_p YHL017W YHL017W hom Uncharacterized 0.150897162790691 0.440028419312537 no 2019 0.434668245127973 1431 NA FT GOLGI APPARATUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein co-localizes with clathrin-coated vesicles; YHL017W has a paralog, PTM1, that arose from the whole genome duplication biological_process molecular_function integral to membrane|clathrin-coated vesicle
YKL087C YKL087C CYT2 hom Verified 0.150227988992261 0.440292372223245 no 2020 0.440403945504781 1444 NA FT PROTEIN COMPLEX ORG/BIOGENESIS MITOCHONDRION Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1 cytochrome c-heme linkage holocytochrome-c synthase activity mitochondrion|mitochondrial intermembrane space
YGL035C YGL035C MIG1 hom Verified 0.149722738786119 0.44049168372091 no 2021 0.455025304828829 1500 NA FT TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS ENDOMEMBRANE SYSTEM|NUCLEUS Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion negative regulation of transcription from RNA polymerase II promoter by glucose|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding nucleus|nuclear envelope lumen|cytoplasm
YCR089W YCR089W FIG2 hom Verified 0.149205365628412 0.440695793114592 no 2022 0.438325545690854 1425 NA FT CELL WALL ORG/BIOGENESIS Cell wall adhesin, expressed specifically during mating; may be involved in maintenance of cell wall integrity during mating filamentous growth of a population of unicellular organisms|cell morphogenesis involved in conjugation with cellular fusion|invasive growth in response to glucose limitation|cytogamy molecular_function fungal-type cell wall|mating projection
YNL214W YNL214W PEX17 hom Verified 0.149105731979551 0.440735101494487 no 2023 0.458793751988078 1514 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PEROXISOME ORGANIZATION Peroxisomal membrane peroxin and subunit of the docking complex that facilitates the import of peroxisomal matrix proteins; required for peroxisome biogenesis protein import into peroxisome matrix, docking protein binding peroxisomal membrane
YOR036W YOR036W PEP12 hom Verified 0.148512428318541 0.440969189169592 no 2024 0.451556083535803 1504 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT GOLGI APPARATUS Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin Golgi to vacuole transport|vacuole inheritance SNAP receptor activity endosome|Golgi apparatus
YPL138C YPL138C SPP1 hom Verified 0.147793846874934 0.441252732746285 no 2025 0.441808733837664 1476 NA FT CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS Subunit of COMPASS (Set1C), a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; interacts with Orc2p; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein histone H3-K4 methylation|regulation of transcription, DNA-dependent|chromatin silencing at telomere histone methyltransferase activity (H3-K4 specific)|chromatin binding|methylated histone residue binding Set1C/COMPASS complex
YBR083W YBR083W TEC1 hom Verified 0.147696598528482 0.441291108088375 no 2026 0.430325988050195 1420 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Transcription factor targeting filamentation genes and Ty1 expression; Ste12p activation of most filamentation gene promoters depends on Tec1p and Tec1p transcriptional activity is dependent on its association with Ste12p; binds to TCS elements upstream of filamentation genes, which are regulated by Tec1p/Ste12p/Dig1p complex; competes with Dig2p for binding to Ste12p/Dig1p; positive regulator of chronological life span; TEA/ATTS DNA-binding domain family member pseudohyphal growth|chronological cell aging|positive regulation of transposition, RNA-mediated|invasive growth in response to glucose limitation|positive regulation of transcription from RNA polymerase II promoter in response to stress RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II transcription factor recruiting transcription factor activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YGL067W YGL067W NPY1 hom Verified 0.147590542538747 0.441332959658498 no 2027 0.420518096368597 1377 NA FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes; nudix hydrolase family member NADH metabolic process NAD+ diphosphatase activity peroxisome|cytoplasm
YKR047W_d YKR047W YKR047W hom Dubious 0.147570167588097 0.441341000049573 no 2028 0.460139767742505 1518 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NAP1 Unknown Unknown Unknown
YGR138C YGR138C TPO2 hom Verified 0.147270374175652 0.441459307731784 no 2029 0.414061438304098 1369 NA FT PLASMA MEMBRANE Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; TPO2 has a paralog, TPO3, that arose from the whole genome duplication spermine transport spermine transmembrane transporter activity fungal-type vacuole membrane|integral to membrane|plasma membrane
YEL063C YEL063C CAN1 hom Verified 0.147191096969 0.441490593824518 no 2030 0.439513158102629 1454 NA FT MITOCHONDRION|PLASMA MEMBRANE Plasma membrane arginine permease; requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; CAN1 has a paralog, ALP1, that arose from the whole genome duplication basic amino acid transport|transmembrane transport basic amino acid transmembrane transporter activity|arginine transmembrane transporter activity mitochondrion|integral to membrane|membrane raft|plasma membrane
YBR174C_d YBR174C YBR174C hom Dubious 0.147115104041521 0.441520584146396 no 2031 0.442433448312805 1470 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YBR175W; null mutant is viable and sporulation defective Unknown Unknown Unknown
YBL083C_d YBL083C YBL083C hom Dubious 0.14643129837046 0.441790460534427 no 2032 0.450815519691411 1488 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified ORF ALG3 Unknown Unknown Unknown
YGR031W YGR031W IMO32 hom Verified 0.146113809282674 0.441915772591291 no 2033 0.452693787445998 1517 NA FT MITOCHONDRION Conserved mitochondrial protein of unknown function; processed by both mitochondrial processing peptidase and mitochondrial octapeptidyl aminopeptidase; gene contains the nested antisense gene NAG1 biological_process molecular_function mitochondrion
YNR036C YNR036C MRPS12 hom Verified 0.146010432832958 0.441956576242664 no 2034 0.447792108050049 1498 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial protein; may interact with ribosomes based on co-purification experiments; similar to E. coli and human mitochondrial S12 ribosomal proteins mitochondrial translation structural constituent of ribosome mitochondrion|ribosome|mitochondrial small ribosomal subunit
YDL183C YDL183C YDL183C hom Verified 0.14600873129944 0.441957247859008 no 2035 0.461752909248335 1535 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene potassium ion transport|proton transport molecular_function integral to mitochondrial inner membrane
YER001W YER001W MNN1 hom Verified 0.145690468885751 0.442082872905954 no 2036 0.434743686580525 1439 NA FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family N-glycan processing|protein O-linked glycosylation alpha-1,3-mannosyltransferase activity Golgi apparatus
YDR029W_d YDR029W YDR029W hom Dubious 0.145597407057486 0.442119607520288 no 2037 0.441521112414691 1441 NA Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDL222C YDL222C FMP45 hom Verified 0.144560586112379 0.442528908997414 no 2038 0.436879562953454 1443 NA FT CELL WALL ORG/BIOGENESIS MITOCHONDRION|PLASMA MEMBRANE Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C fungal-type cell wall organization|ascospore formation molecular_function cell cortex|mitochondrion|integral to membrane|plasma membrane
YCR091W YCR091W KIN82 hom Verified 0.143847588079839 0.442810411882834 no 2039 0.415831204770101 1395 NA FT MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION Putative serine/threonine protein kinase implicated in the regulation of phospholipid asymmetry through the activation of phospholipid translocases (flippases) Lem3p-Dnf1p/Dnf2p; similar to Fpk1p phospholipid translocation|protein phosphorylation|response to pheromone protein kinase activity cellular_component
YLR231C YLR231C BNA5 hom Verified 0.143624975046707 0.44289830894592 no 2040 0.415301401447786 1358 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM NUCLEUS Kynureninase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p de novo NAD biosynthetic process from tryptophan kynureninase activity nucleus|cytoplasm
YER162C YER162C RAD4 hom Verified 0.143119048935567 0.443098080467745 no 2041 0.445592053795679 1482 NA FT RESPONSE TO DNA DAMAGE|PROTEOLYSIS NUCLEUS Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair; subunit of Nuclear Excision Repair Factor 2 (NEF2); also involved, with Rad23p, in turnover of ubiquitylated proteins proteasomal ubiquitin-dependent protein catabolic process|nucleotide-excision repair damaged DNA binding cytosol|nucleotide-excision repair factor 2 complex|nucleus
YGR131W YGR131W FHN1 hom Verified 0.142015626129621 0.443533831460928 no 2042 0.45016465956968 1504 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION PLASMA MEMBRANE Protein of unknown function; induced by ketoconazole; promoter region contains sterol regulatory element motif, which has been identified as a Upc2p-binding site; overexpression complements function of Nce102p in NCE102 deletion strain establishment of protein localization to plasma membrane molecular_function integral to membrane|membrane raft
YGL090W YGL090W LIF1 hom Verified 0.141144658996099 0.443877831994822 no 2043 0.443682249542142 1467 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein double-strand break repair via nonhomologous end joining chromatin binding DNA ligase IV complex|nuclear chromatin|nucleus
YBL013W YBL013W FMT1 hom Verified 0.140214736278218 0.444245164529357 no 2044 0.47469986458244 1585 NA FT KETONE METABOLISM|RNA PROCESSING|AMINO ACID METABOLISM|TRANSLATION MITOCHONDRION Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate translational initiation|methionyl-tRNA aminoacylation methionyl-tRNA formyltransferase activity mitochondrion
YGL110C YGL110C CUE3 hom Verified 0.140212420607824 0.444246079311603 no 2045 0.441842555443664 1436 NA Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination biological_process ubiquitin binding cytoplasm
YPL039W_p YPL039W YPL039W hom Uncharacterized 0.140197117949311 0.444252124480058 no 2046 0.447922132136502 1468 NA Putative protein of unknown function; YPL039W is not an essential gene biological_process molecular_function cellular_component
YJL062W YJL062W LAS21 hom Verified 0.140012773848287 0.444324948867603 no 2047 0.448294382074333 1489 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure; mutations affect cell wall integrity GPI anchor biosynthetic process mannose-ethanolamine phosphotransferase activity|transferase activity integral to endoplasmic reticulum membrane|integral to membrane|integral to plasma membrane
YJL165C YJL165C HAL5 hom Verified 0.139507006450339 0.444524759867382 no 2048 0.429020229164602 1392 NA FT PROTEIN LOCALIZATION|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication cellular cation homeostasis|protein phosphorylation|cellular protein localization|protein dephosphorylation protein kinase activity cellular_component
YOR006C YOR006C TSR3 hom Verified 0.138665571174303 0.444857212714107 no 2049 0.461680657152137 1546 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Protein required for 20S pre-rRNA processing; involved in processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress maturation of SSU-rRNA molecular_function nucleus|cytoplasm
YPR064W_d YPR064W YPR064W hom Dubious 0.13842723465306 0.444951387034901 no 2050 0.432398327574292 1431 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YNL101W YNL101W AVT4 hom Verified 0.138141204136814 0.445064410867686 no 2051 0.438982136634872 1436 NA FT VACUOLAR TRANSPORT Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters amino acid export from vacuole transporter activity|L-glutamine transmembrane transporter activity|L-isoleucine transmembrane transporter activity|L-tyrosine transmembrane transporter activity fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YCL001W-B_p YCL001W-B YCL001W-B hom Uncharacterized 0.137838722852792 0.445183940015046 no 2052 0.464325489344663 1548 NA Putative protein of unknown function; present in a region duplicated between chromosomes XIV and III; YCL001W-B has a paralog, DOM34, that arose from the whole genome duplication biological_process molecular_function cellular_component
YLR108C YLR108C YLR108C hom Verified 0.137772251686402 0.445210207570796 no 2053 0.458048289903595 1505 NA FT NUCLEUS Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene; protein abundance increases in response to DNA replication stress; YLR108C has a paralog, YDR132C, that arose from the whole genome duplication biological_process molecular_function nucleus
YKL190W YKL190W CNB1 hom Verified 0.137537870013325 0.445302830606348 no 2054 0.442560211640792 1452 NA FF|FT SIGNALING|ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1; protein abundance increases in response to DNA replication stress adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|fungal-type cell wall organization|cellular ion homeostasis calcium-dependent protein serine/threonine phosphatase activity|calcium ion binding calcineurin complex
YGR032W YGR032W GSC2 hom Verified 0.137402956567052 0.445356147105876 no 2055 0.442103398981963 1466 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM PLASMA MEMBRANE|CYTOSKELETON Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p) ascospore wall assembly|(1->3)-beta-D-glucan biosynthetic process 1,3-beta-D-glucan synthase activity 1,3-beta-D-glucan synthase complex|integral to membrane|actin cap|prospore membrane
YLR342W YLR342W FKS1 hom Verified 0.137292977312748 0.445399610583259 no 2056 0.446128256270043 1487 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM MITOCHONDRION|PLASMA MEMBRANE|CYTOSKELETON Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling (1->3)-beta-D-glucan biosynthetic process|positive regulation of endocytosis|regulation of cell size 1,3-beta-D-glucan synthase activity mitochondrion|1,3-beta-D-glucan synthase complex|integral to membrane|plasma membrane|cellular bud neck|cellular bud tip|actin cortical patch
YBL042C YBL042C FUI1 hom Verified 0.137260893694409 0.445412290058407 no 2057 0.483589198466498 1619 NA FF|FT PLASMA MEMBRANE High affinity uridine permease, localizes to the plasma membrane; also mediates low but significant transport of the cytotoxic nucleoside analog 5-fluorouridine; not involved in uracil transport; relative distribution to the vacuole increases upon DNA replication stress uridine transport|transmembrane transport uridine transmembrane transporter activity integral to membrane|plasma membrane
YIL163C_p YIL163C YIL163C hom Uncharacterized 0.137116510528908 0.445469351107603 no 2058 0.445610612192587 1468 NA Protein of unknown function; mRNA identified as translated by ribosome profiling data biological_process molecular_function cellular_component
YMR291W YMR291W TDA1 hom Verified 0.137101513681327 0.445475278011949 no 2059 0.42661182067587 1412 NA FT PROTEIN PHOSPHORYLATION NUCLEUS Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; relocalizes from nucleus to cytoplasm upon DNA replication stress protein phosphorylation protein kinase activity nucleus|cytoplasm
YMR183C YMR183C SSO2 hom Verified 0.136118412686375 0.445863835892222 no 2060 0.436222654370472 1452 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p Golgi to plasma membrane transport|ascospore-type prospore assembly|vesicle fusion phosphatidic acid binding|SNAP receptor activity endoplasmic reticulum|plasma membrane|prospore membrane|cytoplasm
YLR324W YLR324W PEX30 hom Verified 0.135745401342952 0.446011277401511 no 2061 0.45869229859171 1507 NA FF|FT PEROXISOME ORGANIZATION Peroxisomal integral membrane protein, involved in negative regulation of peroxisome number; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p peroxisome organization molecular_function integral to membrane|peroxisome|integral to peroxisomal membrane
YJL047C-A_p YJL047C-A YJL047C-A hom Uncharacterized 0.133826968969612 0.446769700432 no 2062 0.445854416401328 1470 NA Putative protein of unknown function biological_process molecular_function cellular_component
YAL028W YAL028W FRT2 hom Verified 0.133788327338157 0.446784978822642 no 2063 0.422723273855661 1396 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Tail-anchored ER membrane protein of unknown function; interacts with homolog Frt1p; promotes growth in conditions of high Na+, alkaline pH, or cell wall stress, possibly via a role in posttranslational translocation; potential Cdc28p substrate; FRT2 has a paralog, FRT1, that arose from the whole genome duplication response to stress molecular_function endoplasmic reticulum
YDR465C YDR465C RMT2 hom Verified 0.133056157529142 0.447074483995197 no 2064 0.464346815793203 1544 NA FT NUCLEUS Arginine N5 methyltransferase; methylates ribosomal protein Rpl12 (L12) on Arg67; relative distribution to the nucleus increases upon DNA replication stress peptidyl-arginine methylation protein-arginine N5-methyltransferase activity nucleus|cytoplasm
YHR086W YHR086W NAM8 hom Verified 0.13177606290176 0.447580710227316 no 2065 0.458662142610077 1517 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING NUCLEUS|MITOCHONDRION RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of REC107 pre-mRNA; Nam8p regulon embraces the meiotic pre-mRNAs of REC107, HFM1, AMA1 SPO22 and PCH2; the putative RNA binding domains RRM2 and RRM3 are required for Nam8p meiotic function mRNA splicing, via spliceosome|positive regulation of mRNA splicing, via spliceosome|mRNA splice site selection mRNA binding|RNA binding commitment complex|U1 snRNP|U2-type prespliceosome
YPR046W YPR046W MCM16 hom Verified 0.130826928021913 0.447956110295378 no 2066 0.47339359151803 1560 NA FT CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME KINETOCHORE Component of the Ctf19 complex and the COMA subcomplex; involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-H and fission yeast fta3 chromosome segregation|establishment of mitotic sister chromatid cohesion molecular_function condensed nuclear chromosome kinetochore
YAL024C YAL024C LTE1 hom Verified 0.130318941283909 0.448157047441147 no 2067 0.458912889757498 1512 NA FF|FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|SIGNALING|CELL DIVISION Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures regulation of exit from mitosis|mitotic cell cycle spindle orientation checkpoint|vesicle-mediated transport guanyl-nucleotide exchange factor activity cellular bud
YCL012C YCL012C YCL012C hom Verified 0.130312435687503 0.448159620854497 no 2068 0.437397325744155 1423 NA Putative protein of unknown function; orthologs are present in S. bayanus, S. paradoxus and Ashbya gossypii; YCL012C is not an essential gene biological_process molecular_function cellular_component
YGR233C YGR233C PHO81 hom Verified 0.130256094177191 0.44818190791004 no 2069 0.459440737388884 1516 NA FT LIPID METABOLISM NUCLEUS Cyclin-dependent kinase (CDK) inhibitor; regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; inhibitory activity for Pho80p-Pho85p requires myo-D-inositol heptakisphosphate (IP7) generated by Vip1p; relative distribution to the nucleus increases upon DNA replication stress phosphate-containing compound metabolic process cyclin-dependent protein kinase inhibitor activity nucleus|cytoplasm
YIL009W YIL009W FAA3 hom Verified 0.129852680150484 0.448341491487954 no 2070 0.437022177355116 1420 NA FT KETONE METABOLISM|LIPID METABOLISM Long chain fatty acyl-CoA synthetase, activates imported fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery long-chain fatty acid metabolic process long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity cellular_component
YER170W YER170W ADK2 hom Verified 0.128023208274798 0.44906530331021 no 2071 0.444209183715778 1456 NA FT NUCLEOTIDE METABOLISM MITOCHONDRION Mitochondrial adenylate kinase, catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background nucleotide metabolic process nucleoside triphosphate adenylate kinase activity|adenylate kinase activity mitochondrion|mitochondrial inner membrane
YIL055C_p YIL055C YIL055C hom Uncharacterized 0.127197382245487 0.449392088609507 no 2072 0.448219693519884 1472 NA Putative protein of unknown function biological_process molecular_function cellular_component
YMR223W YMR223W UBP8 hom Verified 0.126375982626205 0.449717156399684 no 2073 0.436432851448137 1444 NA FT CHROMATIN ORGANIZATION|PROTEOLYSIS NUCLEUS HISTONE ACETYLTRANSFERASE Ubiquitin-specific protease that is a component of the SAGA (Spt-Ada-Gcn5-Acetyltransferase) acetylation complex; required for SAGA-mediated deubiquitination of histone H2B histone H3-K4 methylation|histone deubiquitination|histone H3-K79 methylation ubiquitin-specific protease activity|protein complex scaffold DUBm complex|SLIK (SAGA-like) complex|SAGA complex
YLR284C YLR284C ECI1 hom Verified 0.126035485443309 0.449851917606057 no 2074 0.442352500718378 1446 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS Peroxisomal delta3,delta2-enoyl-CoA isomerase, hexameric protein that converts 3-hexenoyl-CoA to trans-2-hexenoyl-CoA, essential for the beta-oxidation of unsaturated fatty acids, oleate-induced fatty acid beta-oxidation dodecenoyl-CoA delta-isomerase activity peroxisome
YLR050C_p YLR050C YLR050C hom Uncharacterized 0.125962944544545 0.449880628427033 no 2075 0.440410832790917 1471 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLR050C is not an essential gene biological_process molecular_function integral to membrane|endoplasmic reticulum
YMR009W YMR009W ADI1 hom Verified 0.125912656727781 0.449900531898024 no 2076 0.439996963969639 1456 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS NUCLEUS Acireductone dioxygenease involved in the methionine salvage pathway; ortholog of human MTCBP-1; transcribed as polycistronic mRNA with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions L-methionine salvage from methylthioadenosine oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen nucleus|cytoplasm
YOR020W-A_p YOR020W-A YOR020W-A hom Uncharacterized 0.12483572848602 0.450326800693332 no 2077 0.459366862120582 1508 NA FT MITOCHONDRION Putative protein of unknown function, conserved in A. gossypii; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YJL198W YJL198W PHO90 hom Verified 0.124273572408436 0.450549335617717 no 2078 0.446264597710736 1483 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth; PHO90 has a paralog, PHO87, that arose from the whole genome duplication phosphate ion transport phosphate ion transmembrane transporter activity integral to membrane|membrane
YDR369C YDR369C XRS2 hom Verified 0.124144709269197 0.450600349531552 no 2079 0.453495531683354 1501 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling double-strand break repair via nonhomologous end joining|meiotic DNA double-strand break formation|base-excision repair|telomere maintenance|sporulation resulting in formation of a cellular spore|double-strand break repair via break-induced replication single-stranded telomeric DNA binding|protein binding, bridging|DNA binding|double-stranded telomeric DNA binding|telomeric DNA binding|G-quadruplex DNA binding nucleus|Mre11 complex
YNL307C YNL307C MCK1 hom Verified 0.123787565883117 0.45074173853803 no 2080 0.466270619711188 1549 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|CHROMOSOME SEGREGATION Protein serine/threonine/tyrosine (dual-specificity) kinase; involved in control of chromosome segregation and in regulating entry into meiosis; interacts with Clb2p and Mih1p; inhibits Clb2p-Cdk1 activity; related to mammalian glycogen synthase kinases of the GSK-3 family meiosis|double-strand break repair via nonhomologous end joining|ascospore formation|protein phosphorylation|response to stress|mitotic sister chromatid segregation protein serine/threonine/tyrosine kinase activity|protein serine/threonine kinase activity|protein kinase activity cellular_component
YPL141C YPL141C FRK1 hom Verified 0.123026291957964 0.451043139071229 no 2081 0.453792205630328 1498 NA FT PROTEIN PHOSPHORYLATION Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; interacts with rRNA transcription and ribosome biogenesis factors and the long chain fatty acyl-CoA synthetase Faa3p; FRK1 has a paralog, KIN4, that arose from the whole genome duplication protein phosphorylation protein kinase activity cytoplasm
YLR073C YLR073C RFU1 hom Verified 0.122974735396801 0.451063552161674 no 2082 0.462535280154453 1542 NA Protein that inhibits Doa4p deubiquitinating activity; contributes to ubiquitin homeostasis by regulating the conversion of free ubiquitin chains to ubiquitin monomers by Doa4p; GFP-fusion protein localizes to endosomes regulation of ubiquitin homeostasis enzyme inhibitor activity endosome
YPL062W_d YPL062W YPL062W hom Dubious 0.122528738134027 0.451240143860034 no 2083 0.463453597014641 1532 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPL062W is not an essential gene; homozygous diploid mutant shows a decrease in glycogen accumulation Unknown Unknown Unknown
YIL155C YIL155C GUT2 hom Verified 0.121673227405433 0.451578908553142 no 2084 0.43455174337828 1397 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM MITOCHONDRION Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner NADH oxidation|replicative cell aging|glycerol metabolic process glycerol-3-phosphate dehydrogenase activity mitochondrion|integral to mitochondrial outer membrane
YPR139C YPR139C LOA1 hom Verified 0.121620368668399 0.451599840687582 no 2085 0.468411008372419 1555 NA FT PROTEIN LOCALIZATION|VACUOLAR TRANSPORT ENDOPLASMIC RETICULUM Lysophosphatidic acid acyltransferase; involved in triacelglyceride homeostasis and lipid droplet formation; localized to lipid droplets and the ER; specificity for oleoyl-CoA lipid particle organization|cellular triglyceride homeostasis|protein targeting to vacuole lysophosphatidic acid acyltransferase activity endoplasmic reticulum|lipid particle|cytoplasm
YJR128W_d YJR128W YJR128W hom Dubious 0.121409843266028 0.451683210378634 no 2086 0.446376347212394 1490 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSF2 Unknown Unknown Unknown
YLL018C-A YLL018C-A COX19 hom Verified 0.120879851125334 0.451893100800904 no 2087 0.455325409471521 1506 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS MITOCHONDRION Protein required for cytochrome c oxidase assembly, located in the cytosol and mitochondrial intermembrane space; putative copper metallochaperone that delivers copper to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs mitochondrial respiratory chain complex IV assembly|metal ion transport copper ion binding|copper chaperone activity cytosol|mitochondrial intermembrane space
YBR276C YBR276C PPS1 hom Verified 0.120768102097634 0.451937357988172 no 2088 0.417451121853409 1377 NA FT CELL CYCLE|SIGNALING|PROTEIN PHOSPHORYLATION NUCLEUS Protein phosphatase with specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle inactivation of MAPK activity|protein dephosphorylation|regulation of S phase of mitotic cell cycle protein tyrosine/serine/threonine phosphatase activity cellular_component
YJL138C YJL138C TIF2 hom Verified 0.119913549983581 0.452275815297796 no 2089 0.454486594915512 1499 NA FT TRANSLATION RIBOSOME Translation initiation factor eIF4A; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; protein abundance increases in response to DNA replication stress; TIF2 has a paralog, TIF1, that arose from the whole genome duplication translational initiation|regulation of translational initiation ATP-dependent RNA helicase activity|translation initiation factor activity ribosome|eukaryotic translation initiation factor 4F complex|plasma membrane|cytoplasm
YGR017W_p YGR017W YGR017W hom Uncharacterized 0.119376936129396 0.452488366459212 no 2090 0.448462961552921 1468 NA FT OXIDATION-REDUCTION PROCESS NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm biological_process molecular_function nucleus|cytoplasm
YGL059W YGL059W PKP2 hom Verified 0.118792985610892 0.452719683002437 no 2091 0.454986279391253 1508 NA FT CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION MITOCHONDRION Mitochondrial protein kinase; negatively regulates activity of the pyruvate dehydrogenase complex by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp1p and phosphatases Ptc5p and Ptc6p; relocalizes from mitochondrion to cytoplasm upon DNA replication stress peptidyl-serine phosphorylation|protein phosphorylation|carbon utilization|negative regulation of catalytic activity protein kinase activity|pyruvate dehydrogenase (acetyl-transferring) kinase activity mitochondrion
YOL054W YOL054W PSH1 hom Verified 0.117969901428996 0.453045753248852 no 2092 0.45406223429139 1501 NA FT PROTEOLYSIS NUCLEUS|CHROMOSOME E3 ubiquitin ligase that mediates poyubiquitination and degradation of centromere-binding protein Cse4p and prevents Cse4p from mislocalizing to euchromatin; ubiquitylation of Cse4p may be antagonized by Scm3p protein ubiquitination involved in ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity chromosome, centromeric region|nucleus
YOR010C YOR010C TIR2 hom Verified 0.11634823175406 0.453688280863781 no 2093 0.437598664303803 1444 NA Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis response to stress molecular_function fungal-type cell wall
YOR179C YOR179C SYC1 hom Verified 0.11532611307426 0.454093320604556 no 2094 0.455401761256925 1517 NA FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS Subunit of the APT subcomplex of cleavage and polyadenylation factor; may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAs; SYC1 has a paralog, YSH1, that arose from the whole genome duplication termination of RNA polymerase II transcription, exosome-dependent|termination of RNA polymerase II transcription, poly(A)-coupled RNA binding mRNA cleavage and polyadenylation specificity factor complex|nucleus
YHR206W YHR206W SKN7 hom Verified 0.114921899568294 0.454253513375775 no 2095 0.464062377634376 1526 NA FF|FT TRANSCRIPTION FROM RNA POL II|SIGNALING|RESPONSE TO OXIDATIVE STRESS NUCLEUS Nuclear response regulator and transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; part of a branched two-component signaling system; required for optimal induction of heat-shock genes in response to oxidative stress; involved in osmoregulation; SKN7 has a paralog, HMS2, that arose from the whole genome duplication response to singlet oxygen|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|transcription, DNA-dependent|response to osmotic stress|regulation of cell size sequence-specific DNA binding|two-component response regulator activity|sequence-specific DNA binding transcription factor activity nucleus
YBR218C YBR218C PYC2 hom Verified 0.114721023789208 0.454333124687004 no 2096 0.460730618535258 1543 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc1p; mutations in the human homolog are associated with lactic acidosis; PYC2 has a paralog, PYC1, that arose from the whole genome duplication NADPH regeneration|gluconeogenesis pyruvate carboxylase activity cytosol
YNL235C_d YNL235C YNL235C hom Dubious 0.114342328033198 0.454483214795436 no 2097 0.464873567026309 1543 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SIN4/YNL236W, a subunit of the mediator complex Unknown Unknown Unknown
YNL140C_p YNL140C YNL140C hom Uncharacterized 0.11433781720005 0.454485002632438 no 2098 0.497670277435878 1669 NA Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps THO2/YNL139C biological_process molecular_function cellular_component
YJR094W-A YJR094W-A RPL43B hom Verified 0.113785735929974 0.454703823113758 no 2099 0.442932509257542 1467 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L43B; homologous to mammalian ribosomal protein L37A, no bacterial homolog; RPL43B has a paralog, RPL43A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YNL042W YNL042W BOP3 hom Verified 0.113662434142176 0.454752696343232 no 2100 0.439094926074496 1448 NA FT NUCLEUS Protein of unknown function, potential Cdc28p substrate; overproduction confers resistance to methylmercury cellular response to methylmercury molecular_function nucleus|cytoplasm
YGR035W-A_p YGR035W-A YGR035W-A hom Uncharacterized 0.113636041892271 0.45476315754972 no 2101 0.445800467296044 1468 NA Putative protein of unknown function biological_process molecular_function cellular_component
YMR084W_p YMR084W YMR084W hom Uncharacterized 0.113083508223635 0.454982174824106 no 2102 0.450618468159933 1482 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Putative protein of unknown function; YMR084W and adjacent ORF YMR085W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1 biological_process molecular_function cellular_component
YKL068W YKL068W NUP100 hom Verified 0.112376186271385 0.455262568156854 no 2103 0.444586098603668 1480 NA FT PROTEIN LOCALIZATION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; homologous to Nup116p positive regulation of transcription, DNA-dependent|mRNA export from nucleus|NLS-bearing substrate import into nucleus|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|protein import into nucleus|protein targeting to nuclear inner membrane|mRNA export from nucleus in response to heat stress nucleocytoplasmic transporter activity|structural constituent of nuclear pore nuclear pore central transport channel|integral to membrane|nuclear pore
YPR051W YPR051W MAK3 hom Verified 0.111538309362957 0.455594744315861 no 2104 0.470916537815889 1573 NA FT NUCLEUS Catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus N-terminal protein amino acid acetylation peptide alpha-N-acetyltransferase activity NatC complex
YDR051C YDR051C DET1 hom Verified 0.111408854936766 0.455646069275896 no 2105 0.454771803263446 1512 NA FT NUCLEUS Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel intracellular sterol transport|dephosphorylation acid phosphatase activity nucleus|cytoplasm
YPL274W YPL274W SAM3 hom Verified 0.111135206570572 0.455754565424808 no 2106 0.499940762849503 1678 NA FT ENDOPLASMIC RETICULUM|PLASMA MEMBRANE High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p spermidine transport|putrescine transport|S-adenosylmethionine transport S-adenosylmethionine transmembrane transporter activity|spermidine transmembrane transporter activity|putrescine transmembrane transporter activity integral to membrane|plasma membrane
YLR400W_d YLR400W YLR400W hom Dubious 0.110759405448573 0.455903568490557 no 2107 0.460431834736744 1516 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YML106W YML106W URA5 hom Verified 0.110004121859888 0.456203052992361 no 2108 0.457234913694562 1516 NA FT NUCLEOTIDE METABOLISM NUCLEUS Major orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA5 has a paralog, URA10, that arose from the whole genome duplication 'de novo' pyrimidine nucleobase biosynthetic process|pyrimidine ribonucleoside biosynthetic process orotate phosphoribosyltransferase activity nucleus|cytoplasm
YLR238W YLR238W FAR10 hom Verified 0.109877453110445 0.456253282034328 no 2109 0.448684721351432 1460 NA FT CELL CYCLE|SIGNALING ENDOPLASMIC RETICULUM Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far11p; potential Cdc28p substrate re-entry into mitotic cell cycle after pheromone arrest molecular_function endoplasmic reticulum
YMR312W YMR312W ELP6 hom Verified 0.109608815548436 0.456359809495579 no 2110 0.449029016335597 1485 NA FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity protein urmylation|regulation of transcription from RNA polymerase II promoter|tRNA wobble uridine modification ATPase activity|tRNA binding Elongator holoenzyme complex
YER040W YER040W GLN3 hom Verified 0.108843173365782 0.456663439910032 no 2111 0.443066276060788 1474 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS NUCLEUS Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR), localization and activity regulated by quality of nitrogen source nitrogen catabolite activation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity cytosol|nucleus
YJL118W YJL118W YJL118W hom Verified 0.108836184418658 0.456666211630812 no 2112 0.450466157342161 1472 NA Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; YJL18W is a non-essential gene; deletion enhances the toxicity of heterologously expressed human alpha-synuclein biological_process molecular_function ribosome
YOR223W YOR223W YOR223W hom Verified 0.107832292066095 0.457064363434016 no 2113 0.452921826322334 1494 NA FT ENDOPLASMIC RETICULUM Subunit of the DSC ubiquitin ligase complex; protein of unknown function that localizes to the ER and vacuole lumen; overexpression affects endocytic protein trafficking; ortholog of fission yeast dsc3 biological_process molecular_function fungal-type vacuole lumen|endoplasmic reticulum
YMR153W YMR153W NUP53 hom Verified 0.107507156149746 0.457193324220416 no 2114 0.45166498156308 1489 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE FG-nucleoporin component of central core of nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes directly to nucleocytoplasmic transport; involved in regulation of transcription and mitosis; induces membrane tubulation, which may contribute to nuclear pore assembly; NUP53 has a paralog, ASM4, that arose from the whole genome duplication positive regulation of transcription, DNA-dependent|NLS-bearing substrate import into nucleus|regulation of protein desumoylation|nuclear pore organization|protein import into nucleus|regulation of mitosis|mitotic cell cycle spindle assembly checkpoint nucleocytoplasmic transporter activity|phospholipid binding|single-stranded DNA binding nuclear pore central transport channel|nuclear pore nuclear basket|integral to membrane|nuclear pore
YDL062W_d YDL062W YDL062W hom Dubious 0.106779676969257 0.457481885355411 no 2115 0.463180717720343 1542 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YDL063C; YDL062W is not essential Unknown Unknown Unknown
YOL023W YOL023W IFM1 hom Verified 0.106712712190515 0.45750844866387 no 2116 0.467473120319149 1541 NA FT TRANSLATION|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial translation initiation factor 2 translational initiation|mitochondrial translational initiation|mitochondrial translation tRNA binding|GTPase activity|translation initiation factor activity mitochondrion
YJR116W_p YJR116W TDA4 hom Uncharacterized 0.106380812182642 0.457640108170989 no 2117 0.436182988564241 1427 NA Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele biological_process molecular_function integral to membrane
YMR116C YMR116C ASC1 hom Verified 0.106155450844462 0.457729508116111 no 2118 0.453993506724146 1498 NA FT SIGNALING|TRANSLATION RIBOSOME G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; regulates P-body formation induced by replication stress; represses Gcn4p in the absence of amino acid starvation negative regulation of translation|glucose mediated signaling pathway|G-protein coupled receptor signaling pathway|invasive growth in response to glucose limitation G-protein alpha-subunit binding|GDP-dissociation inhibitor activity|signal transducer activity cytosolic small ribosomal subunit|cytoplasm
YMR100W YMR100W MUB1 hom Verified 0.105948776297136 0.457811496965954 no 2119 0.465039627397244 1524 NA FT CELL DIVISION MYND domain-containing protein required for ubiquitination and turnover of Rpn4p; interacts with Ubr2p (E3) and indirectly with Rad6p (E2); short-lived protein degraded in a Ubr2p/Rad6p dependent manner; similar to the A. nidulans samB gene regulation of cell budding|protein monoubiquitination molecular_function cellular_component
YNL249C YNL249C MPA43 hom Verified 0.10568964766407 0.45791429715607 no 2120 0.462705246762508 1538 NA FT CARBOHYDRATE METABOLISM MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YKL100C_p YKL100C YKL100C hom Uncharacterized 0.105142991936806 0.45813117285536 no 2121 0.449807850923145 1516 NA FT PROTEOLYSIS Putative protein of unknown function with similarity to a human minor histocompatibility antigen and signal peptide peptidases; YKL100C is not an essential gene biological_process molecular_function integral to membrane
YMR189W YMR189W GCV2 hom Verified 0.10478496103871 0.458273221850394 no 2122 0.443776894099295 1462 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION P subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of 5,10-methylene-THF in the cytoplasm glycine decarboxylation via glycine cleavage system|one-carbon metabolic process glycine dehydrogenase (decarboxylating) activity mitochondrion|glycine cleavage complex
YKL080W YKL080W VMA5 hom Verified 0.102905948164857 0.459018808406979 no 2123 0.471245999003614 1805 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane vacuolar acidification proton-transporting ATPase activity, rotational mechanism fungal-type vacuole membrane|vacuolar proton-transporting V-type ATPase, V1 domain|integral to membrane
YJL038C