strainid orf gene zyg qualifier SGTC_2826|7992541.score SGTC_2826|7992541.expt.zyg.pval SGTC_2826|7992541.expt.zyg.significant SGTC_2826|7992541.expt.zyg.rank strain.pval strain.rank clearance Fclass Fterms.BP Fterms.CC Fterms.complex description GO_process GO_function GO_component
YMR188C YMR188C MRPS17 hom Verified 6.81077045030613 4.85387132437021e-12 yes 1 1.09337794357975e-11 5 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YMR293C YMR293C HER2 hom Verified 6.27804908716462 1.71423842046245e-10 yes 2 1.06903928407127e-08 9 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION MITOCHONDRION Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase endoplasmic reticulum organization|glutaminyl-tRNAGln biosynthesis via transamidation glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity mitochondrion|glutamyl-tRNA(Gln) amidotransferase complex
YLR428C_d YLR428C YLR428C hom Dubious 6.02417508584671 8.49871444419899e-10 yes 3 1.3254988992595e-09 3 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CRN1 Unknown Unknown Unknown
YGR287C YGR287C IMA1 hom Verified 5.60797031905217 1.02356561161046e-08 yes 4 6.57408373803827e-09 3 NA FT CARBOHYDRATE METABOLISM MITOCHONDRION Major isomaltase (alpha-1,6-glucosidase/alpha-methylglucosidase); required for isomaltose utilization; specificity for isomaltose, alpha-methylglucoside, and palatinose; member of the IMA isomaltase family disaccharide catabolic process oligo-1,6-glucosidase activity mitochondrion|ribosome
YOL018C YOL018C TLG2 hom Verified 5.19489286308702 1.02418885240652e-07 yes 5 0.000917586777891064 58 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT GOLGI APPARATUS Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16) inositolphosphoceramide metabolic process|Golgi to vacuole transport|endocytosis|mannosyl-inositol phosphorylceramide metabolic process|protein exit from endoplasmic reticulum|vesicle fusion|CVT pathway SNAP receptor activity SNARE complex|trans-Golgi network|integral to endosome membrane
YFR023W YFR023W PES4 hom Verified 4.86541941174041 5.71071714879268e-07 yes 6 1.56534341934939e-06 5 NA FT NUCLEUS Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation; PES4 has a paralog, MIP6, that arose from the whole genome duplication biological_process molecular_function cellular_component
YGR130C YGR130C YGR130C hom Verified 4.79569404725326 8.10562759535373e-07 yes 7 5.59842257782271e-06 5 NA Component of the eisosome with unknown function; GFP-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7) biological_process molecular_function eisosome|membrane raft|cytoplasm
YNL069C YNL069C RPL16B hom Verified 4.76104862102601 9.6294819231622e-07 yes 8 8.94207879026013e-06 4 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L16B; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16B has a paralog, RPL16A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YDR377W YDR377W ATP17 hom Verified 4.55673996442818 2.59768387910096e-06 yes 9 4.180397020995e-06 12 NA FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS MITOCHONDRION Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis ATP synthesis coupled proton transport hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism mitochondrion|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
YER123W YER123W YCK3 hom Verified 4.55117265717316 2.66738734033331e-06 yes 10 2.44137287614235e-05 11 NA FT VESICLE-MEDIATED TRANSPORT|PROTEIN PHOSPHORYLATION ENDOMEMBRANE SYSTEM|NUCLEUS|PLASMA MEMBRANE Palmitoylated, vacuolar membrane-localized casein kinase I isoform; negatively regulates vacuole fusion during hypertonic stress via phosphorylation of Vps41p; shares essential functions with Hrr25p; regulates vesicle fusion in AP-3 pathway vesicle-mediated transport|protein phosphorylation protein serine/threonine kinase activity|protein kinase activity fungal-type vacuole membrane|plasma membrane|nucleus|fungal-type vacuole
YLL044W_d YLL044W YLL044W hom Dubious 4.41075850197134 5.15045757939936e-06 yes 11 8.48170744538905e-06 13 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLL044W and the overlapping gene RPL8B is reduced in the gcr1 null mutant Unknown Unknown Unknown
YNR023W YNR023W SNF12 hom Verified 4.36364545185812 6.39564125514122e-06 yes 12 0.000235017370037521 14 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS NUCLEUS RSC COMPLEX 73 kDa subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; homolog of Rsc6p subunit of the RSC chromatin remodeling complex; relocates to the cytosol under hypoxic conditions; deletion mutants are temperature-sensitive positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation|positive regulation of transcription from RNA polymerase II promoter molecular_function SWI/SNF complex
YER167W YER167W BCK2 hom Verified 4.33574775663389 7.26327254984067e-06 yes 13 2.48545611143738e-05 23 NA FT CELL CYCLE NUCLEUS Protein rich in serine and threonine residues involved in protein kinase C signaling pathway, which controls cell integrity; overproduction suppresses pkc1 mutations regulation of cell cycle|positive regulation of gene expression|G1/S transition of mitotic cell cycle molecular_function nucleus|cytoplasm
YLR013W YLR013W GAT3 hom Verified 4.30905283171097 8.19776011879299e-06 yes 14 4.29332276886528e-06 6 NA FT NUCLEUS Protein containing GATA family zinc finger motifs transcription, DNA-dependent sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nucleus
YGR215W YGR215W RSM27 hom Verified 4.28934603388358 8.95999951121614e-06 yes 15 1.92344281963736e-05 20 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YKR019C YKR019C IRS4 hom Verified 4.27253624554579 9.66310634253498e-06 yes 16 0.0262976141532585 262 NA FF|FT LIPID METABOLISM|SIGNALING|CELL WALL ORG/BIOGENESIS|RESPONSE TO NUTRIENT LEVELS|GENE SILENCING MITOCHONDRION EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication autophagy|fungal-type cell wall organization|chromatin silencing at rDNA|inositol lipid-mediated signaling|CVT pathway|cellular response to starvation molecular_function mitochondrion|pre-autophagosomal structure
YHR162W YHR162W MPC2 hom Verified 4.24244075956618 1.10550957859004e-05 yes 17 1.42709846735978e-05 10 NA Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; more highly expressed in glucose-containing minimal medium than in lactate-containing medium mitochondrial pyruvate transport pyruvate transmembrane transporter activity mitochondrion|integral to mitochondrial inner membrane
YGL063W YGL063W PUS2 hom Verified 4.03230992858173 2.76156406467277e-05 yes 18 3.01975494411384e-05 16 NA FT RNA PROCESSING MITOCHONDRION Mitochondrial tRNA:pseudouridine synthase; acts at positions 27 and 28, but not at position 72; efficiently and rapidly targeted to mitochondria, specifically dedicated to mitochondrial tRNA modification tRNA pseudouridine synthesis pseudouridine synthase activity mitochondrion
YOL033W YOL033W MSE1 hom Verified 3.9715825169519 3.56983806610047e-05 yes 19 0.000185731848315045 19 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial glutamyl-tRNA synthetase, predicted to be palmitoylated mitochondrial glutamyl-tRNA aminoacylation|glutamyl-tRNA aminoacylation|mitochondrial translation glutamate-tRNA(Gln) ligase activity|glutamate-tRNA ligase activity mitochondrion
YCR032W YCR032W BPH1 hom Verified 3.95832697014854 3.77382944560319e-05 yes 20 3.88016063492834e-05 12 NA FT PROTEIN LOCALIZATION|CELL WALL ORG/BIOGENESIS MITOCHONDRION Protein homologous to Chediak-Higashi syndrome and Beige proteins; both of which are implicated in disease syndromes in human and mouse, respectively, due to defective lysosomal trafficking; mutant phenotype and genetic interactions suggest a role in protein sorting intracellular protein transport|fungal-type cell wall organization|response to pH molecular_function cytosol|mitochondrion|extrinsic to membrane
YHR126C_p YHR126C ANS1 hom Uncharacterized 3.83485191445407 6.2819983880094e-05 yes 21 4.93192718282313e-05 12 NA FT PLASMA MEMBRANE Putative GPI protein; transcription dependent upon Azf1p biological_process molecular_function cellular_component
YAL031C YAL031C GIP4 hom Verified 3.74760872602349 8.92642289895111e-05 yes 22 4.58893324374428e-05 15 NA FT CHROMOSOME SEGREGATION Cytoplasmic Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; potential Cdc28p substrate chromosome segregation|regulation of phosphoprotein phosphatase activity protein phosphatase 1 binding|protein phosphatase type 1 regulator activity cytoplasm
YLR295C YLR295C ATP14 hom Verified 3.52008789777519 0.000215701903649482 yes 23 0.000832600227038994 42 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS MITOCHONDRION Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; protein abundance increases in response to DNA replication stress cristae formation|mitochondrial proton-transporting ATP synthase complex assembly|ATP synthesis coupled proton transport hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
YCR002C YCR002C CDC10 hom Verified 3.49755186362054 0.000234774702385444 yes 24 0.000760886671735655 36 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Component of the septin ring, required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells; N-terminus interacts with phosphatidylinositol-4,5-bisphosphate; protein abundance increases under DNA damage stress sporulation|maintenance of cell polarity|exit from mitosis|cell cycle cytokinesis|septin ring assembly protein complex scaffold|structural molecule activity|GTP binding|GTPase activity|1-phosphatidylinositol binding spindle microtubule|ascospore-type prospore|septin complex|prospore membrane|mating projection base|meiotic spindle|septin filament array|cellular bud neck septin ring|mating projection tip
YEL046C YEL046C GLY1 hom Verified 3.4072827737334 0.000328065562977535 yes 25 0.00165855735947799 50 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Threonine aldolase, catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis threonine catabolic process|glycine biosynthetic process threonine aldolase activity|L-allo-threonine aldolase activity cytosol
YDR195W YDR195W REF2 hom Verified 3.39071087971123 0.00034855800045247 yes 26 0.000820746626913474 30 NA FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS RNA-binding protein involved in the cleavage step of mRNA 3'-end formation prior to polyadenylation, and in snoRNA maturation; part of holo-CPF subcomplex APT, which associates with 3'-ends of snoRNA- and mRNA-encoding genes mRNA 3'-end processing|termination of RNA polymerase II transcription, poly(A)-coupled|snoRNA 3'-end processing|Unknown chromatin binding|RNA binding mRNA cleavage and polyadenylation specificity factor complex|nucleus
YPR047W YPR047W MSF1 hom Verified 3.38463163096256 0.000356369178088746 yes 27 0.000785997503585823 49 NA FT KETONE METABOLISM|RNA PROCESSING|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial phenylalanyl-tRNA synthetase, active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase phenylalanyl-tRNA aminoacylation|mitochondrial phenylalanyl-tRNA aminoacylation phenylalanine-tRNA ligase activity mitochondrion
YIL011W YIL011W TIR3 hom Verified 3.37728364348501 0.000366027591608166 yes 28 0.000184786952866281 21 NA Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth biological_process molecular_function fungal-type cell wall
YNL235C_d YNL235C YNL235C hom Dubious 3.37445915184714 0.000369804458313879 yes 29 0.00119633480427168 68 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SIN4/YNL236W, a subunit of the mediator complex Unknown Unknown Unknown
YCL056C YCL056C PEX34 hom Verified 3.31364114213927 0.000460448077592023 yes 30 0.00057937609106827 33 NA FT PEROXISOME ORGANIZATION Peroxisomal integral membrane protein that regulates peroxisome populations; interacts with Pex11p, Pex25p, and Pex27p to control both constitutive peroxisome division and peroxisome morphology and abundance during peroxisome proliferation peroxisome organization molecular_function integral to peroxisomal membrane|cytoplasm
YJR098C_p YJR098C YJR098C hom Uncharacterized 3.30477013969142 0.000475271613656348 yes 31 0.000167240242539451 4 NA FT LIPID METABOLISM MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion|cytoplasm
YER128W YER128W VFA1 hom Verified 3.30357188152219 0.00047730746337132 yes 32 0.000459054311420946 34 NA FT VACUOLAR TRANSPORT Protein that interacts with Vps4p and has a role in vacuolar sorting; localizes to endosomes in a Vps4-dependent manner; overexpression causes canavanine sensitivity and confers a partial class D vacuole morphology vacuolar transport molecular_function endosome|cytoplasm
YBR084C-A YBR084C-A RPL19A hom Verified 3.2516762784432 0.000573633042498721 yes 33 0.000897744645969374 37 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L19A; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19A has a paralog, RPL19B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YJL186W YJL186W MNN5 hom Verified 3.24720627316793 0.000582719453403051 yes 34 0.000156320346813548 22 NA FT CARBOHYDRATE METABOLISM GOLGI APPARATUS Alpha-1,2-mannosyltransferase, responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment protein glycosylation alpha-1,2-mannosyltransferase activity Golgi apparatus
YMR157C YMR157C AIM36 hom Verified 3.23954115459038 0.000598610939629177 yes 35 0.00138063954617621 33 NA FT MITOCHONDRION Protein of unknown function; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YNL063W YNL063W MTQ1 hom Verified 3.23442654571819 0.000609436345673993 yes 36 0.000683659412942918 23 NA FT TRANSLATION MITOCHONDRION S-adenosylmethionine-dependent methyltransferase; methylates translational release factor Mrf1p; similar to E.coli PrmC; is not an essential gene translational readthrough S-adenosylmethionine-dependent methyltransferase activity mitochondrion
YLR244C YLR244C MAP1 hom Verified 3.2331497627088 0.00061216680027389 yes 37 0.00124761601338778 29 NA FT PROTEOLYSIS RIBOSOME Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p negative regulation of gene expression|protein initiator methionine removal involved in protein maturation metalloaminopeptidase activity|mRNA binding cytosolic ribosome
YOR283W YOR283W YOR283W hom Verified 3.23154039411334 0.000615624599544621 yes 38 0.000570873270960635 21 NA FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Phosphatase with a broad substrate specificity and some similarity to GPM1/YKL152C, a phosphoglycerate mutase; YOR283W is not an essential gene dephosphorylation phosphatase activity nucleus|cytoplasm
YBR001C YBR001C NTH2 hom Verified 3.20123187204068 0.000684206828059267 yes 39 0.000949981731953474 88 NA FF|FT CARBOHYDRATE METABOLISM MITOCHONDRION Putative neutral trehalase, required for thermotolerance; may mediate resistance to other cellular stresses; NTH2 has a paralog, NTH1, that arose from the whole genome duplication trehalose catabolic process alpha,alpha-trehalase activity mitochondrion|cytoplasm
YHR194W YHR194W MDM31 hom Verified 3.17609717215917 0.000746354706691018 yes 40 0.00118742178570934 41 NA FT ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS NUCLEUS|MITOCHONDRION Mitochondrial protein that may have a role in phospholipid metabolism; inner membrane protein with similarity to Mdm32p; required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MMM2, MDM10, MDM12, and MDM34 mitochondrion inheritance|cellular ion homeostasis|mitochondrion organization|Unknown molecular_function mitochondrial inner membrane|nucleus
YMR105W-A_p YMR105W-A YMR105W-A hom Uncharacterized 3.1319812592856 0.00086815479042263 yes 41 0.00197002225053177 60 NA Putative protein of unknown function biological_process molecular_function cellular_component
YBR013C_p YBR013C YBR013C hom Uncharacterized 3.12302674903923 0.000895007393870666 yes 42 0.00115771662031982 75 NA Putative protein of unknown function, haploid deletion mutant exhibits synthetic phenotype with alpha-synuclein biological_process molecular_function cellular_component
YMR286W YMR286W MRPL33 hom Verified 3.10832957085153 0.000940740635911103 yes 43 0.00126698819573115 43 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YBL104C YBL104C SEA4 hom Verified 3.07290516113458 0.00105992923459885 no 44 0.00203488716349198 69 NA Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; has an N-terminal beta-propeller fold and a C-terminal RING motif; promoter contains multiple GCN4 binding sites biological_process molecular_function Seh1-associated complex|extrinsic to fungal-type vacuolar membrane|cytoplasm
YKL080W YKL080W VMA5 hom Verified 3.06275650982521 0.00109654213493509 no 45 0.00322157567334877 43 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane vacuolar acidification proton-transporting ATPase activity, rotational mechanism fungal-type vacuole membrane|vacuolar proton-transporting V-type ATPase, V1 domain|integral to membrane
YGR160W_d YGR160W YGR160W hom Dubious 3.05913526182852 0.00110988451149667 no 46 0.000949588205432978 18 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR282C_d YLR282C YLR282C hom Dubious 3.04789702664691 0.0011522444024943 no 47 0.000606952914114722 29 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition Unknown Unknown Unknown
YNL271C YNL271C BNI1 hom Verified 3.04339799282673 0.00116961366316764 no 48 0.00641613086009503 91 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1 barbed-end actin filament capping|actin nucleation|actin filament bundle assembly involved in cytokinetic actomyosin contractile ring assembly|establishment of mitotic spindle orientation|formin-nucleated actin cable assembly profilin binding incipient cellular bud site|actin filament|polarisome|plasma membrane|cellular bud neck|mating projection tip|cellular bud tip
YNR037C YNR037C RSM19 hom Verified 2.99898992106684 0.00135438133689187 no 49 0.00305505312541062 55 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S19 ribosomal protein mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YKL068W-A_p YKL068W-A YKL068W-A hom Uncharacterized 2.99002013359339 0.00139479529639432 no 50 0.00545286094180037 91 NA Putative protein of unknown function; identified by homology to Ashbya gossypii biological_process molecular_function cellular_component
YPL193W YPL193W RSA1 hom Verified 2.98710757729649 0.00140815300628843 no 51 0.00467027511241997 72 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS NUCLEUS Protein involved in the assembly of 60S ribosomal subunits; functionally interacts with Dbp6p; functions in a late nucleoplasmic step of the assembly ribosomal large subunit assembly molecular_function nucleoplasm
YDL066W YDL066W IDP1 hom Verified 2.97722543783595 0.00145435021399534 no 52 0.00818670309577714 129 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes isocitrate metabolic process|glutamate biosynthetic process isocitrate dehydrogenase (NADP+) activity mitochondrial nucleoid|mitochondrion
YDL122W YDL122W UBP1 hom Verified 2.97696833705037 0.00145557036755531 no 53 0.00117932248502103 51 NA FT PROTEOLYSIS ENDOPLASMIC RETICULUM Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains protein deubiquitination ubiquitin-specific protease activity endoplasmic reticulum|cytoplasm
YCL023C_d YCL023C YCL023C hom Dubious 2.97680569397955 0.00145634272438134 no 54 0.000633663052917826 12 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF KCC4 Unknown Unknown Unknown
YGR102C YGR102C GTF1 hom Verified 2.97310001305323 0.00147404186392097 no 55 0.0016556359580856 54 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION MITOCHONDRION Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria glutaminyl-tRNAGln biosynthesis via transamidation glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity mitochondrion|glutamyl-tRNA(Gln) amidotransferase complex
YDR463W YDR463W STP1 hom Verified 2.96337699748278 0.0015214182259643 no 56 0.0114977592929839 82 NA FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS|PLASMA MEMBRANE Transcription factor; undergoes proteolytic processing by SPS (Ssy1p-Ptr3p-Ssy5p)-sensor component Ssy5p in response to extracellular amino acids; activates transcription of amino acid permease genes and may have a role in tRNA processing; STP1 has a paralog, STP2, that arose from the whole genome duplication positive regulation of transcription, DNA-dependent|tRNA splicing, via endonucleolytic cleavage and ligation|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription plasma membrane|nucleus|cytoplasm
YPL172C YPL172C COX10 hom Verified 2.9520988321983 0.00157810946044251 no 57 0.00371856290119454 86 NA FT COFACTOR METABOLISM MITOCHONDRION Heme A:farnesyltransferase, catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; human ortholog is associated with mitochondrial disorders heme a biosynthetic process protoheme IX farnesyltransferase activity mitochondrion|integral to membrane
YBR238C YBR238C YBR238C hom Verified 2.94972981495549 0.00159025966589533 no 58 0.00611497892073708 74 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Mitochondrial membrane protein with similarity to Rmd9p; not required for respiratory growth but causes a synthetic respiratory defect in combination with rmd9 mutations; transcriptionally up-regulated by TOR; deletion increases life span aerobic respiration molecular_function mitochondrion|integral to mitochondrial membrane|cytoplasm
YMR205C YMR205C PFK2 hom Verified 2.94121171896102 0.00163465497321974 no 59 0.00476960551868396 104 NA FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes proton transport|glycolysis mRNA binding|6-phosphofructokinase activity mitochondrion|6-phosphofructokinase complex|cytoplasm
YBR170C YBR170C NPL4 hom Verified 2.91152282868238 0.00179835811908472 no 60 0.0019516509283096 37 NA FT PROTEIN LOCALIZATION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM UBIQUITIN LIGASE COMPLEX Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; assists Cdc48p in the dislocation of misfolded, polyubiquitinated ERAD substrates that are subsequently delivered to the proteasome for degradation; also involved in the regulated destruction of resident ER membrane proteins, such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing (RUP) retrograde protein transport, ER to cytosol|proteasomal ubiquitin-dependent protein catabolic process|mitochondria-associated protein catabolic process|mitotic spindle disassembly|ER-associated protein catabolic process|ER-associated misfolded protein catabolic process|Unknown|cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process molecular_function Doa10p ubiquitin ligase complex|integral to membrane|Cdc48p-Npl4p-Ufd1p AAA ATPase complex|Cdc48p-Npl4p-Vms1p AAA ATPase complex|nuclear outer membrane-endoplasmic reticulum membrane network
YGL231C YGL231C EMC4 hom Verified 2.88806470564695 0.00193810062624914 no 61 0.0040433987726252 51 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm ZK616.6/EMC-4, fly CG11137, human TMM85 protein folding in endoplasmic reticulum molecular_function ER membrane protein complex|endoplasmic reticulum
YOR205C YOR205C GEP3 hom Verified 2.87585951426661 0.00201464500398174 no 62 0.00230248249570196 76 NA FT MITOCHONDRION Protein required for mitochondrial ribosome small subunit biogenesis; null mutant is defective in respiration and in maturation of 15S rRNA; protein is localized to the mitochondrial inner membrane; null mutant interacts synthetically with prohibitin (phb1) maturation of SSU-rRNA molecular_function mitochondrion|mitochondrial inner membrane
YGR163W YGR163W GTR2 hom Verified 2.87530696830158 0.002018174336254 no 63 0.00873367789607788 129 NA FF|FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|MEMBRANE ORGANIZATION NUCLEUS|CHROMOSOME Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD microautophagy|positive regulation of transcription from RNA polymerase II promoter GTP binding nuclear chromatin|fungal-type vacuole membrane|integral to membrane|EGO complex|nucleus|late endosome membrane|cytoplasm
YIL167W YIL167W SDL1 hom pseudogene 2.87276708765495 0.00203446987491451 no 64 0.00222222439222686 40 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Open reading frame, unlikely to produce a functional protein in S288C; in closely related species and other S. cerevisiae strain backgrounds YIL167W and adjacent ORF, YIL168W, constitute a single ORF encoding L-serine dehydratase serine family amino acid metabolic process L-serine ammonia-lyase activity cellular_component
YOL087C YOL087C DUF1 hom Verified 2.864560124184 0.00208794435806375 no 65 0.0102031077518359 96 NA Ubiquitin-binding protein of unknown function; contains one WD40 repeat in a beta-propeller fold; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; homolog of human WDR48/UAF1, which is involved in regulating the Fanconi anemia pathway; deletion mutant is sensitive to various chemicals including phenanthroline, sanguinarine, and nordihydroguaiaretic acid biological_process ubiquitin binding cytoplasm
YKR100C YKR100C SKG1 hom Verified 2.84464997863442 0.00222301247851864 no 66 0.00300066226964655 56 NA FT CELL WALL ORG/BIOGENESIS SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Transmembrane protein with a role in cell wall polymer composition; localizes on the inner surface of the plasma membrane at the bud and in the daughter cell fungal-type cell wall organization molecular_function incipient cellular bud site|cellular bud|cellular bud tip
YOL001W YOL001W PHO80 hom Verified 2.83259431539696 0.00230859714750522 no 67 0.00663385041334235 160 NA FF|FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CELL CYCLE|SIGNALING|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS|RESPONSE TO NUTRIENT LEVELS NUCLEUS Cyclin, interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling negative regulation of phosphate metabolic process|regulation of cyclin-dependent protein kinase activity|negative regulation of calcium-mediated signaling|negative regulation of transcription from RNA polymerase II promoter|cellular metal ion homeostasis|regulation of protein localization|negative regulation of macroautophagy cyclin-dependent protein kinase regulator activity cyclin-dependent protein kinase holoenzyme complex|nucleus
YBR026C YBR026C ETR1 hom Verified 2.79224545701951 0.00261718163496505 no 68 0.00452922552231719 84 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION 2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family; localized to in mitochondria, where it has a probable role in fatty acid synthesis fatty acid biosynthetic process|aerobic respiration enoyl-[acyl-carrier-protein] reductase activity mitochondrion
YDR149C_d YDR149C YDR149C hom Dubious 2.78755295555778 0.00265538868215054 no 69 0.00239641765787118 78 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene NUM1; null mutation blocks anaerobic growth Unknown Unknown Unknown
YBR007C YBR007C DSF2 hom Verified 2.77973009875397 0.00272020475990624 no 70 0.00394634211195292 137 NA FF Deletion suppressor of mpt5 mutation; relocalizes from bud neck to cytoplasm upon DNA replication stress biological_process molecular_function cellular_component
YCR064C_d YCR064C YCR064C hom Dubious 2.77966772374243 0.00272072725650141 no 71 0.00823987347722773 127 NA FF Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31 Unknown Unknown Unknown
YHL004W YHL004W MRP4 hom Verified 2.7790275018267 0.00272609544151381 no 72 0.00314505424470371 81 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit mitochondrial translation structural constituent of ribosome|tRNA binding mitochondrion|mitochondrial small ribosomal subunit
YDR354W YDR354W TRP4 hom Verified 2.77711205396996 0.00274221338881492 no 73 0.105706558693712 596 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis tryptophan biosynthetic process anthranilate phosphoribosyltransferase activity nucleus|cytoplasm
YPR159W YPR159W KRE6 hom Verified 2.77206849208517 0.00278506575267158 no 74 0.00755855057905846 70 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Type II integral membrane protein required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; localizes to the ER, plasma membrane, sites of polarized growth and secretory vesicles; functionally redundant with Skn1p fungal-type cell wall organization|(1->6)-beta-D-glucan biosynthetic process glucosidase activity integral to endoplasmic reticulum membrane|integral to membrane|site of polarized growth|transport vesicle|plasma membrane
YBR223C YBR223C TDP1 hom Verified 2.76640493845759 0.00283390534051894 no 75 0.00345060243746108 39 NA FT RESPONSE TO DNA DAMAGE NUCLEUS Tyrosyl-DNA phosphodiesterase I; hydrolyzes 3' and 5'-phosphotyrosyl bonds; involved in the repair of DNA lesions created by topoisomerase I and topoisomerase II; mutations in human homolog result in the neurodegenerative disease SCANI DNA repair 3'-tyrosyl-DNA phosphodiesterase activity|5'-tyrosyl-DNA phosphodiesterase activity nucleus
YBR172C YBR172C SMY2 hom Verified 2.75168976557714 0.00296443289998042 no 76 0.00130602886722102 37 NA FT VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein of unknown function involved in COPII vesicle formation; interacts with the Sec23p/Sec24p subcomplex; overexpression suppresses the temperature sensitivity of a myo2 mutant; similar to S. pombe Mpd2; SMY2 has a paralog, SYH1, that arose from the whole genome duplication ER to Golgi vesicle-mediated transport molecular_function endoplasmic reticulum membrane|cytoplasmic mRNA processing body|cytoplasm|extrinsic to membrane
YGR056W YGR056W RSC1 hom Verified 2.74868110281743 0.00299177848181884 no 77 0.0187151629937216 162 NA FF|FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS RSC COMPLEX Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook double-strand break repair|ATP-dependent chromatin remodeling|regulation of sporulation resulting in formation of a cellular spore|double-strand break repair via nonhomologous end joining|nucleosome disassembly|transcription elongation from RNA polymerase II promoter DNA-dependent ATPase activity RSC complex
YOL132W YOL132W GAS4 hom Verified 2.74788896947432 0.00299901583862942 no 78 0.00197929797368263 41 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM PLASMA MEMBRANE 1,3-beta-glucanosyltransferase, involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall ascospore wall assembly 1,3-beta-glucanosyltransferase activity fungal-type cell wall|integral to membrane
YBR037C YBR037C SCO1 hom Verified 2.73778189214577 0.00309275418148357 no 79 0.004484470567682 73 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Copper-binding protein of mitochondrial inner membrane; required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; similar to thioredoxins; SCO1 has a paralog, SCO2, that arose from the whole genome duplication copper ion transport|response to redox state|protein complex assembly copper ion binding|thioredoxin peroxidase activity mitochondrion|mitochondrial inner membrane
YMR072W YMR072W ABF2 hom Verified 2.73210451297382 0.00314655872957917 no 80 0.0033601611760792 84 NA FT MITOCHONDRION ORGANIZATION NUCLEUS|MITOCHONDRION|CHROMOSOME Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation mitochondrion inheritance|mitochondrial DNA packaging|mitochondrial genome maintenance DNA binding, bending|DNA binding mitochondrial nucleoid|mitochondrial chromosome|mitochondrion
YGR015C_p YGR015C YGR015C hom Uncharacterized 2.72943479792649 0.00317214968411691 no 81 0.00455878962734058 48 NA FT MITOCHONDRION Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion biological_process molecular_function mitochondrion
YBR039W YBR039W ATP3 hom Verified 2.72857710114773 0.00318041093124721 no 82 0.00625249736314682 108 NA FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS MITOCHONDRION Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis ATP synthesis coupled proton transport proton-transporting ATPase activity, rotational mechanism mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase, central stalk
YLR262C YLR262C YPT6 hom Verified 2.71659938024785 0.00329781951799732 no 83 0.0425260061309498 219 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING GOLGI APPARATUS|PLASMA MEMBRANE Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6 intracellular protein transport|retrograde transport, endosome to Golgi GTPase activity Golgi apparatus
YPL157W YPL157W TGS1 hom Verified 2.70916530957077 0.00337263610867191 no 84 0.00457618490616797 101 NA FT CELL CYCLE|RNA PROCESSING NUCLEUS Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs meiosis|RNA methylation|nucleologenesis|7-methylguanosine cap hypermethylation|regulation of telomere maintenance via telomerase RNA methyltransferase activity nucleolus
YGL176C_p YGL176C YGL176C hom Uncharacterized 2.70910186488775 0.00337328112958699 no 85 0.00448815258278408 57 NA Putative protein of unknown function; deletion mutant is viable and has no detectable phenotype biological_process molecular_function cellular_component
YGR034W YGR034W RPL26B hom Verified 2.70392368053663 0.00342630130989058 no 86 0.00645972338080085 56 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L26B; binds to 5.8S rRNA; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26B has a paralog, RPL26A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YOR258W YOR258W HNT3 hom Verified 2.69860052445845 0.00348158522953468 no 87 0.00915067285925237 115 NA FT RESPONSE TO DNA DAMAGE NUCLEUS DNA 5' AMP hydrolase involved in DNA repair; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins; homolog of Aprataxin, a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxia; relative distribution to nuclear foci decreases upon DNA replication stress response to DNA damage stimulus DNA 5'-adenosine monophosphate hydrolase activity nucleus|cytoplasm
YER129W YER129W SAK1 hom Verified 2.69615308338252 0.0035072710863224 no 88 0.00544187771513579 84 NA FT CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION Upstream serine/threonine kinase for the SNF1 complex; partially redundant with Elm1p and Tos3p; members of this family have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome protein phosphorylation|glucose metabolic process|DNA-dependent DNA replication protein serine/threonine kinase activity|protein kinase activity cytoplasm
YOR008C YOR008C SLG1 hom Verified 2.69350932925977 0.0035352083350273 no 89 0.0241169287646235 180 NA FF|FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|PEROXISOME ORGANIZATION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway; involved in maintenance of cell wall integrity; required for mitophagy; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response positive regulation of endocytosis|Rho protein signal transduction|actin cytoskeleton organization|fungal-type cell wall organization|response to heat|peroxisome degradation|establishment of cell polarity|response to osmotic stress transmembrane signaling receptor activity plasma membrane|mating projection tip|cellular bud neck
YNL116W YNL116W DMA2 hom Verified 2.68450246064551 0.00363189243093733 no 90 0.00745794295842022 68 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION Ubiquitin-protein ligase (E3); controls septin dynamics and the spindle position checkpoint (SPOC) along with functionally redundant ligase Dma1p by regulating the recruitment of Elm1p to the bud neck; regulates levels of the translation initiation factor eIF2 subunit Gcd11p, as well as abundance, localization, and ubiquitination of Cdk inhibitory kinase Swe1p; ortholog of human RNF8 protein, with sequence similarity to human Chfr; contains FHA and RING finger domains establishment of mitotic spindle orientation|protein autoubiquitination|septin ring assembly|mitotic cell cycle spindle assembly checkpoint ubiquitin-protein ligase activity cytoplasm
YDR194C YDR194C MSS116 hom Verified 2.66858803183513 0.00380854072795859 no 91 0.00551083036328279 86 NA FT RNA PROCESSING|TRANSLATION MITOCHONDRION DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing RNA folding|Group I intron splicing|Group II intron splicing RNA binding|RNA strand annealing activity|ATP-dependent RNA helicase activity mitochondrion|mitochondrial matrix
YJL175W_d YJL175W YJL175W hom Dubious 2.66602968976373 0.00383764571554374 no 92 0.00244503913069991 24 NA Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor Unknown Unknown Unknown
YPL080C_d YPL080C YPL080C hom Dubious 2.6649503262074 0.00384998477897389 no 93 0.00619868652031775 77 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YBR194W YBR194W AIM4 hom Verified 2.65182136226447 0.00400294431987787 no 94 0.0104729716673642 82 NA Protein proposed to be associated with the nuclear pore complex; null mutant is viable, displays elevated frequency of mitochondrial genome loss and is sensitive to freeze-thaw stress biological_process molecular_function cytoplasm
YBL106C YBL106C SRO77 hom Verified 2.63789537097963 0.00417111581632072 no 95 0.00899341130991298 148 NA FF|FT VESICLE-MEDIATED TRANSPORT PLASMA MEMBRANE Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lethal giant larvae tumor suppressor; interacts with SNARE protein Sec9p; SRO77 has a paralog, SRO7, that arose from the whole genome duplication exocytosis|Golgi to plasma membrane transport molecular_function plasma membrane
YDR024W_d YDR024W FYV1 hom Dubious 2.61977303591001 0.00439941526792053 no 96 0.00714606718344235 78 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; mutation decreases survival upon exposure to K1 killer toxin Unknown Unknown Unknown
YGR225W YGR225W AMA1 hom Verified 2.61584009766254 0.0044504114974715 no 97 0.00351691429661201 45 NA FT CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION NUCLEUS UBIQUITIN LIGASE COMPLEX Activator of meiotic anaphase promoting complex (APC/C); Cdc20p family member; required for initiation of spore wall assembly; required for Clb1p degradation during meiosis ascospore wall assembly|positive regulation of protein catabolic process|ascospore formation|meiosis I enzyme activator activity anaphase-promoting complex
YDL075W YDL075W RPL31A hom Verified 2.61518703076997 0.0044589303830461 no 98 0.0110420111021878 91 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L31A; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31A has a paralog, RPL31B, that arose from the whole genome duplication cytoplasmic translation|regulation of translational fidelity structural constituent of ribosome cytosolic large ribosomal subunit
YIR023W YIR023W DAL81 hom Verified 2.61197542827759 0.00450103619832892 no 99 0.0783396234874694 490 NA FF|FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|RESPONSE TO NUTRIENT LEVELS NUCLEUS Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism nitrogen utilization|nitrogen catabolite activation of transcription from RNA polymerase II promoter|gamma-aminobutyric acid catabolic process|urea catabolic process RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor recruiting transcription factor activity nucleus
YPL139C YPL139C UME1 hom Verified 2.61098269293421 0.00451412313288048 no 100 0.00464899997215404 95 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Negative regulator of meiosis, required for repression of a subset of meiotic genes during vegetative growth, binding of histone deacetylase Rpd3p required for activity, contains a NEE box and a WD repeat motif; homologous with Wtm1p, Wtm2p positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of transcription from RNA polymerase I promoter|negative regulation of chromatin silencing at telomere|positive regulation of transcription from RNA polymerase II promoter|regulation of meiosis transcription corepressor activity Rpd3S complex|Rpd3L-Expanded complex|nucleus|Rpd3L complex
YLL006W YLL006W MMM1 hom Verified 2.60680927252445 0.00456951250725022 no 101 0.0142263970661755 118 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION ER integral membrane protein, component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth mitochondrion organization|mitochondrial genome maintenance|protein import into mitochondrial outer membrane|phospholipid transport molecular_function mitochondrial outer membrane|mitochondrion|integral to endoplasmic reticulum membrane|ERMES complex
YMR196W_p YMR196W YMR196W hom Uncharacterized 2.60514562007536 0.00459176098619319 no 102 0.00845707480184138 104 NA FT CARBOHYDRATE METABOLISM Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene biological_process molecular_function cytoplasm
YML055W YML055W SPC2 hom Verified 2.60434504157684 0.00460250175952751 no 103 0.00808347395724855 78 NA FT PROTEIN LOCALIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC25 signal peptide processing|protein targeting to ER peptidase activity signal peptidase complex
YDL020C YDL020C RPN4 hom Verified 2.60305012388673 0.00461992219085799 no 104 0.112952119362357 558 NA FF|FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|PROTEOLYSIS NUCLEUS Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance|regulation of DNA repair|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YOL145C YOL145C CTR9 hom Verified 2.57708212773725 0.0049819136874288 no 105 0.0102319835824205 135 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|GENE SILENCING NUCLEUS|CHROMOSOME RNA POL II, HOLOENZYME Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cyclin genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; contains TPR repeats transcription elongation from RNA polymerase I promoter|mRNA 3'-end processing|regulation of chromatin silencing at telomere|snoRNA transcription from an RNA polymerase II promoter|regulation of transcription by chromatin organization|transcription from RNA polymerase I promoter|regulation of histone H3-K4 methylation|regulation of transcription-coupled nucleotide-excision repair|regulation of transcription initiation from RNA polymerase II promoter|snoRNA 3'-end processing|Unknown|regulation of transcription involved in G1 phase of mitotic cell cycle|transcription elongation from RNA polymerase II promoter RNA polymerase II core binding|triplex DNA binding|RNA polymerase II transcription factor binding transcription factor activity transcriptionally active chromatin|nucleus|Cdc73/Paf1 complex
YJL038C YJL038C LOH1 hom Verified 2.55693949104616 0.00527987920995423 no 106 0.00542650706241403 59 NA Protein of unknown function with proposed roles in maintenance of genome integrity and also in spore wall assembly; induced during sporulation; repressed during vegetative growth by Sum1p and Hst1p; sequence similar to IRC1 chromosome organization molecular_function cellular_component
YOR192C YOR192C THI72 hom Verified 2.52287598779211 0.00581997208882587 no 107 0.00663414241281581 96 NA Transporter of thiamine or related compound; shares sequence similarity with Thi7p thiamine transport transporter activity integral to membrane|membrane
YJL099W YJL099W CHS6 hom Verified 2.52050450008103 0.00585933699222918 no 108 0.00991241914860724 122 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM GOLGI APPARATUS Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication Golgi to plasma membrane transport|fungal-type cell wall chitin biosynthetic process molecular_function trans-Golgi network transport vesicle|clathrin-coated vesicle|exomer complex
YLR032W YLR032W RAD5 hom Verified 2.52047338242194 0.00585985508792651 no 109 0.00746869029043745 115 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME DNA helicase; proposed to promote replication fork regression during postreplication repair by template switching; RING finger containing ubiquitin ligase; stimulates the synthesis of free and PCNA-bound polyubiquitin chains by Ubc13p-Mms2p; required for error-prone translesion synthesis; forms nuclear foci upon DNA replication stress double-strand break repair|postreplication repair|protein polyubiquitination|free ubiquitin chain polymerization four-way junction helicase activity|four-way junction DNA binding|DNA-dependent ATPase activity|Y-form DNA binding nuclear chromatin
YPL068C_p YPL068C YPL068C hom Uncharacterized 2.51640816377379 0.00592788966009998 no 110 0.00892440208531147 69 NA FT NUCLEUS Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and is induced in response to the DNA-damaging agent MMS biological_process molecular_function nucleus
YKR029C YKR029C SET3 hom Verified 2.51238445157694 0.00599591843994448 no 111 0.00694475106439097 86 NA FT CELL CYCLE|CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Defining member of the SET3 histone deacetylase complex which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains; SET3 has a paralog, SET4, that arose from the whole genome duplication negative regulation of meiosis|regulation of transcription, DNA-dependent|histone deacetylation methylated histone residue binding Rpd3L-Expanded complex|Set3 complex
YIL173W YIL173W VTH1 hom Verified 2.50600402844724 0.00610521143221609 no 112 0.00202245035857928 46 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT GOLGI APPARATUS Putative membrane glycoprotein with strong similarity to Vth2p and Pep1p/Vps10p, may be involved in vacuolar protein sorting Golgi to vacuole transport signal sequence binding endosome|integral to membrane
YMR073C YMR073C IRC21 hom Verified 2.50592563042239 0.00610656525236847 no 113 0.0336719631220132 225 NA FF Putative protein of unknown function; may be involved in resistance to carboplatin and cisplatin; null mutant displays increase in spontaneous Rad52p foci; contains a lipid-binding domain and binds cardiolipin in a large-scale study response to drug molecular_function cytoplasm
YNR065C_p YNR065C YNR065C hom Uncharacterized 2.49924142913106 0.00622297439849151 no 114 0.00668807746584257 89 NA Protein of unknown function; protein-protein interactions suggest a possible role in actin patch formation; YNR065C is not an essential gene biological_process molecular_function integral to membrane
YLR182W YLR182W SWI6 hom Verified 2.49856998379788 0.00623477592989565 no 115 0.0119635758822764 112 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE NUCLEUS Transcription cofactor; forms complexes with Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; also binds Stb1p to regulate transcription at START; cell wall stress induces phosphorylation by Mpk1p, which regulates Swi6p localization; required for the unfolded protein response, independently of its known transcriptional coactivators positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription involved in G1/S phase of mitotic cell cycle|positive regulation of reciprocal meiotic recombination|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription coactivator activity SBF transcription complex|MBF transcription complex|nucleus|cytoplasm
YDR408C YDR408C ADE8 hom Verified 2.49704752875273 0.00626160851882108 no 116 0.00852165079584799 80 NA FT NUCLEOTIDE METABOLISM NUCLEUS Phosphoribosyl-glycinamide transformylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway purine nucleotide biosynthetic process|'de novo' IMP biosynthetic process|adenine biosynthetic process phosphoribosylglycinamide formyltransferase activity nucleus|cytoplasm
YHR143W YHR143W DSE2 hom Verified 2.49665624304774 0.00626852125011532 no 117 0.0151488206210932 151 NA FF|FT CELL WALL ORG/BIOGENESIS|CELL DIVISION Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP cytokinesis, completion of separation|pseudohyphal growth glucosidase activity extracellular region|fungal-type cell wall
YGR027C YGR027C RPS25A hom Verified 2.49562957166118 0.00628669129175619 no 118 0.0124344186062467 78 NA FT TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S25, no bacterial homolog; RPS25A has a paralog, RPS25B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic small ribosomal subunit
YLR292C YLR292C SEC72 hom Verified 2.48977745459528 0.00639115526627928 no 119 0.0110586913811509 122 NA FT PROTEIN LOCALIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER posttranslational protein targeting to membrane, translocation protein transporter activity Sec62/Sec63 complex|endoplasmic reticulum membrane
YMR287C YMR287C DSS1 hom Verified 2.48591045114776 0.00646102385099192 no 120 0.015453807903722 121 NA FT MITOCHONDRION 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs mitochondrial RNA catabolic process exoribonuclease II activity mitochondrion|mitochondrial degradosome
YIL090W YIL090W ICE2 hom Verified 2.46546410993642 0.00684179414143705 no 121 0.00885105856673952 95 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Integral ER membrane protein with type-III transmembrane domains; required for maintenance of ER zinc homeostasis; necessary for efficient targeting of Trm1p tRNA methyltransferase to inner nuclear membrane; mutations cause defects in cortical ER morphology in both the mother and daughter cells endoplasmic reticulum inheritance molecular_function integral to endoplasmic reticulum membrane|integral to membrane|endoplasmic reticulum
YDR507C YDR507C GIN4 hom Verified 2.46459907784112 0.00685833176260485 no 122 0.00623479546694316 122 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION SITE OF POLARIZED GROWTH Protein kinase involved in bud growth and assembly of the septin ring; proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Hsl1p; GIN4 has a paralog, KCC4, that arose from the whole genome duplication protein autophosphorylation|budding cell bud growth|protein phosphorylation|septin checkpoint|septin ring assembly protein kinase activity cellular bud neck
YBR069C YBR069C TAT1 hom Verified 2.46051460554442 0.00693689624394427 no 123 0.103676236637262 423 NA FF|FT PLASMA MEMBRANE Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress amino acid transport|tyrosine transport|tryptophan transport|transmembrane transport amino acid transmembrane transporter activity|low-affinity tryptophan transmembrane transporter activity integral to membrane|plasma membrane
YPR106W YPR106W ISR1 hom Verified 2.45941753699095 0.00695813318428657 no 124 0.00914240297707644 76 NA FT PROTEIN PHOSPHORYLATION Predicted protein kinase, overexpression causes sensitivity to staurosporine, which is a potent inhibitor of protein kinase C biological_process protein kinase activity cellular_component
YPL198W YPL198W RPL7B hom Verified 2.44319453490957 0.00727894385817194 no 125 0.00890000509503017 71 NA FT TRANSLATION NUCLEUS RIBOSOME Ribosomal 60S subunit protein L7B; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7B has a paralog, RPL7A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit|nucleolus|cytoplasm
YHR195W YHR195W NVJ1 hom Verified 2.44244225910512 0.00729413152554495 no 126 0.0088347201776863 120 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|NUCLEUS Nuclear envelope protein, anchored to the nuclear inner membrane, that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN) microautophagy|cellular protein localization protein binding nuclear envelope
YPR134W YPR134W MSS18 hom Verified 2.43964055000643 0.00735094118781068 no 127 0.00795342382331038 116 NA FT RNA PROCESSING MITOCHONDRION Nuclear encoded protein needed for efficient splicing of mitochondrial COX1 aI5beta intron; mss18 mutations block cleavage of 5' exon - intron junction; phenotype of intronless strain suggests additional functions Group I intron splicing molecular_function mitochondrion
YGL240W YGL240W DOC1 hom Verified 2.43408300489586 0.00746478551038604 no 128 0.0094270470050946 123 NA FT CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION|PROTEOLYSIS NUCLEUS|MITOCHONDRION UBIQUITIN LIGASE COMPLEX Processivity factor required for the ubiquitination activity of the anaphase promoting complex (APC), mediates the activity of the APC by contributing to substrate recognition; involved in cyclin proteolysis; contains a conserved DOC1 homology domain activation of mitotic anaphase-promoting complex activity|chromatin assembly|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cyclin catabolic process enzyme regulator activity|mitotic anaphase-promoting complex activity mitochondrion|anaphase-promoting complex
YDL179W YDL179W PCL9 hom Verified 2.43126660527377 0.00752306932060468 no 129 0.00820999449371535 73 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION SITE OF POLARIZED GROWTH Cyclin, forms a functional kinase complex with Pho85p cyclin-dependent kinase (Cdk), expressed in late M/early G1 phase, activated by Swi5p regulation of establishment or maintenance of cell polarity|regulation of transcription involved in G1/S phase of mitotic cell cycle cyclin-dependent protein kinase regulator activity cyclin-dependent protein kinase holoenzyme complex|incipient cellular bud site|cellular bud neck
YGR162W YGR162W TIF4631 hom Verified 2.42458144032322 0.00766302267935505 no 130 0.0124318283830368 112 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION MITOCHONDRION RIBOSOME Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication translational initiation|ribosomal large subunit biogenesis|stress granule assembly translation initiation factor activity mitochondrion|ribosome|eukaryotic translation initiation factor 4F complex|cytoplasmic stress granule
YDR350C YDR350C ATP22 hom Verified 2.41967113370453 0.00776727458577632 no 131 0.0091533693669746 69 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Specific translational activator for the mitochondrial ATP6 mRNA, encoding a subunit of F1F0 ATP synthase; localized to the mitochondrial inner membrane proton-transporting ATP synthase complex biogenesis|positive regulation of mitochondrial translation translation regulator activity mitochondrial inner membrane
YLR246W YLR246W ERF2 hom Verified 2.40637166957059 0.00805593180421375 no 132 0.00353699644241208 61 NA FT PROTEIN LOCALIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Subunit of a palmitoyltransferase, composed of Erf2p and Shr5p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; mutants partially mislocalize Ras2p to the vacuole protein targeting to membrane|protein palmitoylation palmitoyltransferase activity endoplasmic reticulum palmitoyltransferase complex|integral to endoplasmic reticulum membrane|integral to membrane
YDR214W YDR214W AHA1 hom Verified 2.39355793668578 0.00834292291950563 no 133 0.0108062857481688 84 NA FT NUCLEOTIDE METABOLISM Co-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is regulated by stresses such as heat shock; protein abundance increases in response to DNA replication stress protein folding|response to stress ATPase activator activity|chaperone binding cytoplasm
YPR029C YPR029C APL4 hom Verified 2.38543380521047 0.00852949604688828 no 134 0.00678878681398233 93 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport Golgi to vacuole transport|vesicle-mediated transport clathrin binding AP-1 adaptor complex
YOL091W YOL091W SPO21 hom Verified 2.35863456780023 0.00917115409532537 no 135 0.00689922922142585 96 NA FT CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION CYTOSKELETON Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation ascospore wall assembly|meiosis structural molecule activity spindle pole body
YCR006C_d YCR006C YCR006C hom Dubious 2.35836215282739 0.00917788783567748 no 136 0.0110627903164325 96 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YHR204W YHR204W MNL1 hom Verified 2.34928321295038 0.00940479685942397 no 137 0.00776190560630269 112 NA FT PROTEOLYSIS ENDOPLASMIC RETICULUM Alpha-1,2-specific exomannosidase of the endoplasmic reticulum; in complex with Pdi1p, generates a Man7GlcNac2 oligosaccharide signal on glycoproteins destined for ubiquitin-proteasome degradation ER-associated protein catabolic process carbohydrate binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity endoplasmic reticulum lumen
YOR334W YOR334W MRS2 hom Verified 2.34683504686128 0.00946681743805278 no 138 0.00677271183338386 75 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Mitochondrial inner membrane Mg(2+) channel, required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns mitochondrial magnesium ion transport magnesium ion transmembrane transporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YMR070W YMR070W MOT3 hom Verified 2.34382323672773 0.00954360750739918 no 139 0.0186659663349712 179 NA FT TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM NUCLEUS Transcriptional repressor and activator with two C2-H2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes in response to hyperosmotic stress; contributes to recruitment of the Tup1p-Cyc8p general repressor to promoters; involved in positive transcriptional regulation of CWP2 and other genes; can form the [MOT3+] prion cellular hyperosmotic response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of ergosterol biosynthetic process|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II repressing transcription factor binding|RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding nucleus
YGR222W YGR222W PET54 hom Verified 2.3437232677856 0.0095461656578027 no 140 0.0134933266326642 124 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial inner membrane protein; binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing Group I intron splicing|positive regulation of mitochondrial translation|mitochondrial respiratory chain complex IV biogenesis translation regulator activity|RNA binding mitochondrion|extrinsic to mitochondrial inner membrane|mitochondrial inner membrane|mitochondrial matrix
YER068W YER068W MOT2 hom Verified 2.33929758644846 0.00966001876738116 no 141 0.0126577000401768 70 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications deadenylation-independent decapping of nuclear-transcribed mRNA|positive regulation of transcription elongation from RNA polymerase II promoter|protein polyubiquitination|protein ubiquitination ubiquitin-protein ligase activity|sequence-specific DNA binding CCR4-NOT core complex|cytoplasm
YER154W YER154W OXA1 hom Verified 2.33843224254326 0.00968241838903627 no 142 0.015777757202926 162 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial inner membrane insertase, mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane, interacts with mitochondrial ribosomes; conserved from bacteria to animals protein insertion into mitochondrial membrane from inner side|mitochondrial genome maintenance|mitochondrial proton-transporting ATP synthase complex assembly mitochondrial ribosome binding|membrane insertase activity mitochondrion|mitochondrial inner boundary membrane|integral to membrane|mitochondrial crista|mitochondrial large ribosomal subunit
YFL001W YFL001W DEG1 hom Verified 2.33198626059449 0.00985070698086936 no 143 0.0192252829579749 113 NA FT RNA PROCESSING NUCLEUS tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm; non-essential for viability tRNA pseudouridine synthesis pseudouridine synthase activity nucleus|cytoplasm
YLR312W-A YLR312W-A MRPL15 hom Verified 2.3238617272729 0.0100664530539445 no 144 0.0121910443649257 116 NA FT RNA PROCESSING|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YPR054W YPR054W SMK1 hom Verified 2.32068681832332 0.0101518763325125 no 145 0.00416159642812993 71 NA FT SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION MITOCHONDRION Middle sporulation-specific mitogen-activated protein kinase (MAPK) required for production of the outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p ascospore wall assembly|protein phosphorylation|negative regulation of sporulation resulting in formation of a cellular spore MAP kinase activity mitochondrion
YPL039W_p YPL039W YPL039W hom Uncharacterized 2.31624992208005 0.0102723134331808 no 146 0.015094022902553 135 NA Putative protein of unknown function; YPL039W is not an essential gene biological_process molecular_function cellular_component
YOL093W YOL093W TRM10 hom Verified 2.30943821252654 0.010459638313763 no 147 0.0154076254419271 101 NA FT RNA PROCESSING NUCLEUS tRNA methyltransferase; methylates the N-1 position of guanosine in tRNAs; protein abundance increases in response to DNA replication stress tRNA methylation tRNA (guanine) methyltransferase activity nucleus|cytoplasm
YLR331C_d YLR331C JIP3 hom Dubious 2.30803252495637 0.0104986637700196 no 148 0.00987947197879934 111 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2 Unknown Unknown Unknown
YGL143C YGL143C MRF1 hom Verified 2.30770394533305 0.0105078042489543 no 149 0.0269051325796937 145 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial translation release factor, involved in stop codon recognition and hydrolysis of the peptidyl-tRNA bond during mitochondrial translation; lack of MRF1 causes mitochondrial genome instability translational termination|mitochondrial translational termination|mitochondrial translation translation release factor activity mitochondrion
YOR183W_p YOR183W FYV12 hom Uncharacterized 2.30561322925026 0.0105661267075715 no 150 0.0122880080118389 118 NA Protein of unknown function, required for survival upon exposure to K1 killer toxin biological_process molecular_function cellular_component
YJL062W YJL062W LAS21 hom Verified 2.30330415129292 0.0106308681201817 no 151 0.0116837697036781 157 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure; mutations affect cell wall integrity GPI anchor biosynthetic process mannose-ethanolamine phosphotransferase activity|transferase activity integral to endoplasmic reticulum membrane|integral to membrane|integral to plasma membrane
YIL053W YIL053W RHR2 hom Verified 2.3030878463544 0.0106369504920827 no 152 0.0201636951630587 187 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Constitutively expressed glycerol-1-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and osmotic stress; RHR2 has a paralog, HOR2, that arose from the whole genome duplication glycerol biosynthetic process|response to osmotic stress glycerol-1-phosphatase activity nucleus|cytoplasm
YFL012W_p YFL012W YFL012W hom Uncharacterized 2.30006112026016 0.0107223787874489 no 153 0.0175737418908098 126 NA Putative protein of unknown function; transcribed during sporulation; null mutant exhibits increased resistance to rapamycin biological_process molecular_function cellular_component
YKR040C_d YKR040C YKR040C hom Dubious 2.29902740085889 0.0107516917082191 no 154 0.00825203739410898 79 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YKR041W Unknown Unknown Unknown
YML090W_d YML090W YML090W hom Dubious 2.29789846624852 0.0107837843061684 no 155 0.00944796051553714 77 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source Unknown Unknown Unknown
YPR166C YPR166C MRP2 hom Verified 2.29389526578994 0.0108982577133013 no 156 0.0202246682368447 134 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YDR182W-A_p YDR182W-A YDR182W-A hom Uncharacterized 2.29175822609707 0.0109597992206048 no 157 0.0148467056730234 120 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YEL029C YEL029C BUD16 hom Verified 2.2912216960019 0.010975297376663 no 158 0.0310639927306413 186 NA FT CELL CYCLE|CELL DIVISION|COFACTOR METABOLISM NUCLEUS Putative pyridoxal kinase, a key enzyme involved in pyridoxal 5'-phosphate synthesis, the active form of vitamin B6; required for genome integrity; involved in bud-site selection; similarity to yeast BUD17 and human pyridoxal kinase (PDXK) pyridoxal phosphate biosynthetic process|cellular bud site selection pyridoxal kinase activity cytoplasm
YOL116W YOL116W MSN1 hom Verified 2.28223639139819 0.0112376938281759 no 159 0.0118731530552038 106 NA FT TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM NUCLEUS Transcriptional activator; involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress; localizes to the nucleus; relative distribution to the nucleus increases upon DNA replication stress positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription from RNA polymerase II promoter in response to methylglyoxal|positive regulation of transcription from RNA polymerase II promoter in response to increased salt|Unknown|positive regulation of starch catabolic process by positive regulation of transcription from RNA polymerase II promoter|positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding nucleus
YCL050C YCL050C APA1 hom Verified 2.27803743930268 0.0113621735277817 no 160 0.0101865146264438 86 NA FT NUCLEOTIDE METABOLISM NUCLEUS AP4A phosphorylase; bifunctional diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase and ADP sulfurylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; catalyzes phosphorolysis of dinucleoside oligophosphates, cleaving substrates' alpha/beta-anhydride bond and introducing Pi into the beta-position of the corresponding NDP formed; protein abundance increases under DNA replication stress; APA1 has a paralog, APA2, that arose from the whole genome duplication nucleotide biosynthetic process|nucleoside catabolic process bis(5'-nucleosyl)-tetraphosphatase activity|sulfate adenylyltransferase (ADP) activity nucleus|cytoplasm
YJL127C YJL127C SPT10 hom Verified 2.27136752386285 0.0115623693454139 no 161 0.0107542369193732 130 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING NUCLEUS Putative histone acetylase with a role in transcriptional silencing, sequence-specific activator of histone genes, binds specifically and cooperatively to pairs of UAS elements in core histone promoters, functions at or near the TATA box DNA repair|negative regulation of transcription from RNA polymerase II promoter|chromatin silencing at rDNA|chromatin remodeling|chromatin silencing at telomere|chromatin silencing at silent mating-type cassette histone acetyltransferase activity|sequence-specific DNA binding nucleus
YER106W YER106W MAM1 hom Verified 2.26737139504172 0.0116837736982316 no 162 0.0088852415019065 131 NA FT CELL CYCLE|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME KINETOCHORE Monopolin, kinetochore associated protein involved in chromosome attachment to meiotic spindle meiotic chromosome segregation|meiotic sister chromatid cohesion involved in meiosis I molecular_function condensed nuclear chromosome kinetochore|monopolin complex
YDL071C_d YDL071C YDL071C hom Dubious 2.26650129058498 0.0117103541134822 no 163 0.0190266605839344 124 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF BDF2/YDL070W Unknown Unknown Unknown
YLL005C YLL005C SPO75 hom Verified 2.26531081269409 0.0117468064911758 no 164 0.0052838467571598 71 NA FT CELL WALL ORG/BIOGENESIS Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis ascospore wall assembly|ascospore formation molecular_function integral to membrane
YLR313C YLR313C SPH1 hom Verified 2.26175857197996 0.0118561618610976 no 165 0.0153776015917046 144 NA FT CELL CYCLE|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Protein involved in shmoo formation and bipolar bud site selection; homologous to Spa2p, localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p bipolar cellular bud site selection|pseudohyphal growth|invasive filamentous growth|mating projection assembly molecular_function incipient cellular bud site|cellular bud neck|cellular bud tip|mating projection
YIL133C YIL133C RPL16A hom Verified 2.25799016948217 0.011973136162108 no 166 0.0152351877441748 114 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L16A; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16A has a paralog, RPL16B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress cytoplasmic translation structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YJR055W YJR055W HIT1 hom Verified 2.25461386879963 0.0120787880830011 no 167 0.00728663791833354 114 NA FT NUCLEUS Protein of unknown function, required for growth at high temperature biological_process molecular_function nucleus|cytoplasm
YJR107W_p YJR107W YJR107W hom Uncharacterized 2.24840473655445 0.0122751967184641 no 168 0.0103948703781634 73 NA FT LIPID METABOLISM Putative lipase biological_process lipase activity cellular_component
YLR312C_p YLR312C YLR312C hom Uncharacterized 2.23762542451317 0.0126227460726824 no 169 0.01391496676397 99 NA Putative protein of unknown function biological_process molecular_function cellular_component
YEL028W_d YEL028W YEL028W hom Dubious 2.23580176111888 0.0126823797687362 no 170 0.0213170764455072 143 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YMR258C YMR258C ROY1 hom Verified 2.23436744225497 0.0127294530506533 no 171 0.0137771754064172 131 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|NUCLEUS GTPase inhibitor with similarity to F-box proteins; inhibits Ypt52p GTPase activity by preventing Ypt52p from binding GTP; involved in regulating intracellular trafficking; physically interacts with Skp1p endocytosis|protein targeting to vacuole|negative regulation of GTPase activity GTPase inhibitor activity nucleus|cytoplasm
YDL073W_p YDL073W YDL073W hom Uncharacterized 2.23345854039593 0.0127593607245713 no 172 0.0227912850486437 138 NA Putative protein of unknown function; YDL073W is not an essential gene biological_process molecular_function cellular_component
YER010C YER010C YER010C hom Verified 2.22678108514029 0.0129809540652555 no 173 0.0149589322263461 125 NA Protein of unknown function, forms a ring-shaped homotrimer; has similarity to members of the prokaryotic rraA family; possibly involved in a phosphotransfer reaction biological_process molecular_function cellular_component
YNL228W_d YNL228W YNL228W hom Dubious 2.22181234174961 0.0131479951570861 no 174 0.0204375227409685 158 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF YNL227C/JJJ1 Unknown Unknown Unknown
YCR003W YCR003W MRPL32 hom Verified 2.21630284555325 0.0133353841423749 no 175 0.0298539837733139 192 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit
YNL252C YNL252C MRPL17 hom Verified 2.21223903048402 0.0134750766653192 no 176 0.0153344458237394 161 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YGR063C YGR063C SPT4 hom Verified 2.20886589829337 0.0135919848915198 no 177 0.0377381789698597 210 NA FF|FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION|CHROMOSOME SEGREGATION|GENE SILENCING NUCLEUS|CHROMOSOME Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair; Spt4p also localizes to kinetochores and heterochromatin and affects chromosome dynamics and silencing; required for transcription through lengthy trinucleotide repeats in ORFs or non-protein coding regions 7-methylguanosine mRNA capping|chromosome segregation|chromatin organization|intracellular mRNA localization|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription, DNA-dependent|regulation of transcription-coupled nucleotide-excision repair|chromatin silencing|mRNA splicing, via spliceosome|Unknown core RNA polymerase I binding transcription factor activity|core RNA polymerase II binding transcription factor activity|rDNA binding DSIF complex|nuclear telomeric heterochromatin|rDNA heterochromatin|mating-type region heterochromatin|kinetochore
YNL338W_d YNL338W YNL338W hom Dubious 2.20875370014297 0.0135958885243417 no 178 0.00923006238202296 98 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps TEL14L-XC, which is Telomeric X element Core sequence on the left arm of Chromosome XIV Unknown Unknown Unknown
YNL051W YNL051W COG5 hom Verified 2.20364563627727 0.0137746375808699 no 179 0.0659100355628089 294 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments intra-Golgi vesicle-mediated transport|CVT pathway molecular_function Golgi transport complex
YNL081C YNL081C SWS2 hom Verified 2.20191318561159 0.0138357207055841 no 180 0.0354016438901379 214 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency regulation of sporulation resulting in formation of a cellular spore|mitochondrial translation structural constituent of ribosome mitochondrial small ribosomal subunit|cytoplasm
YIR026C YIR026C YVH1 hom Verified 2.19971536181192 0.0139135480993766 no 181 0.0150435818642636 117 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RIBOSOME BIOGENESIS|SIGNALING|CELL WALL ORG/BIOGENESIS NUCLEUS Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases meiosis|ascospore wall assembly|ribosomal large subunit assembly|cAMP-mediated signaling|protein dephosphorylation protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity nucleus|preribosome, large subunit precursor|cytoplasm
YPR084W_p YPR084W YPR084W hom Uncharacterized 2.18709790081237 0.0143676889294901 no 182 0.0131100357844648 116 NA Putative protein of unknown function biological_process molecular_function cellular_component
YGR121W-A_p YGR121W-A YGR121W-A hom Uncharacterized 2.18278860267227 0.0145256906947599 no 183 0.0120553782327796 97 NA Putative protein of unknown function biological_process molecular_function cellular_component
YIL101C YIL101C XBP1 hom Verified 2.18072760452177 0.014601785013317 no 184 0.0156276985363791 130 NA FT NUCLEUS Transcriptional repressor; binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4p/Mbp1p family; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress response to stress sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nucleus
YKL136W_d YKL136W YKL136W hom Dubious 2.17246659553981 0.0149102433054329 no 185 0.0244695681794754 123 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF APL2/YKL135C Unknown Unknown Unknown
YJR105W YJR105W ADO1 hom Verified 2.15806916048134 0.0154612275307196 no 186 0.0538317458515068 300 NA FF|FT NUCLEOTIDE METABOLISM NUCLEUS Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle purine nucleobase metabolic process adenosine kinase activity nucleus|cytoplasm
YKR057W YKR057W RPS21A hom Verified 2.15165757857234 0.0157121667972675 no 187 0.0197765525565632 128 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21A has a paralog, RPS21B, that arose from the whole genome duplication cytoplasmic translation|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit
YCR068W YCR068W ATG15 hom Verified 2.15052167460948 0.0157569867057712 no 188 0.0252415387423718 181 NA FT LIPID METABOLISM|MEMBRANE ORGANIZATION|VACUOLAR PROTEIN PROCESSING ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Lipase required for intravacuolar lysis of autophagic bodies and Cvt bodies; targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway membrane disassembly|autophagy|piecemeal microautophagy of nucleus|vacuolar protein processing|multivesicular body membrane disassembly lipase activity integral to membrane|vacuolar lumen
YPL240C YPL240C HSP82 hom Verified 2.15018454939458 0.01577030990275 no 189 0.0205759477722568 136 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION Hsp90 chaperone; redundant in function with Hsc82p; required for pheromone signaling, negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding, nucleotide addition; protein abundance increases in response to DNA replication stress; contains two acid-rich unstructured regions that promote solubility of chaperone-substrate complexes; HSP82 has a paralog, HSC82, that arose from the whole genome duplication proteasome assembly|positive regulation of telomere maintenance via telomerase|box C/D snoRNP assembly|response to stress|protein refolding|protein targeting to mitochondrion|response to osmotic stress|'de novo' protein folding unfolded protein binding|ATPase activity, coupled cytoplasm
YER150W YER150W SPI1 hom Verified 2.14848042299587 0.0158378049836018 no 190 0.0170636204040018 129 NA GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p response to acid molecular_function fungal-type cell wall
YNL237W YNL237W YTP1 hom Verified 2.12861058833325 0.01664324587851 no 191 0.0487183573448202 247 NA FF|FT MITOCHONDRION Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins biological_process molecular_function integral to membrane|membrane
YDL045W-A YDL045W-A MRP10 hom Verified 2.12815107892166 0.0166622797182738 no 192 0.0340967307888035 129 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit; contains twin cysteine-x9-cysteine motifs mitochondrial translation|mitochondrial respiratory chain complex assembly structural constituent of ribosome mitochondrial small ribosomal subunit
YPL184C YPL184C MRN1 hom Verified 2.12592914436565 0.0167545798797082 no 193 0.0179481465874882 150 NA FT TRANSLATION RNA-binding protein that may be involved in translational regulation; binds specific categories of mRNAs, including those that contain upstream open reading frames (uORFs) and internal ribosome entry sites (IRES); interacts genetically with chromatin remodelers and splicing factors, linking chromatin state, splicing and as a result mRNA maturation biological_process molecular_function cytoplasm
YML102W YML102W CAC2 hom Verified 2.12218702684904 0.0169110177680076 no 194 0.0178936980313152 99 NA FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription DNA replication-dependent nucleosome assembly histone binding chromosome, centromeric region|CAF-1 complex
YKR078W YKR078W YKR078W hom Verified 2.1186198208477 0.0170613046352833 no 195 0.0187144976638601 142 NA Cytoplasmic protein of unknown function, has similarity to Vps5p; potential Cdc28p substrate; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P) biological_process phosphatidylinositol-3-phosphate binding cytoplasm
YPR191W YPR191W QCR2 hom Verified 2.11232222573223 0.0173294103863311 no 196 0.0128841959240183 116 NA FT OXIDATION-REDUCTION PROCESS|PROTEOLYSIS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Subunit 2 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; phosphorylated; transcription is regulated by Hap1p, Hap2p/Hap3p, and heme mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration ubiquinol-cytochrome-c reductase activity mitochondrion|integral to membrane|mitochondrial crista|mitochondrial respiratory chain complex III
YBR163W YBR163W EXO5 hom Verified 2.11198235126939 0.0173439815452867 no 197 0.0226521404313776 206 NA FT MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial 5'-3' exonuclease and sliding exonuclease, required for mitochondrial genome maintenance; distantly related to the RecB nuclease domain of bacterial RecBCD recombinases; may be regulated by the transcription factor Ace2 mitochondrial genome maintenance single-stranded DNA specific 5'-3' exodeoxyribonuclease activity mitochondrion
YMR069W YMR069W NAT4 hom Verified 2.10593991464056 0.017604785972797 no 198 0.0258272859072454 143 NA FT CHROMATIN ORGANIZATION NUCLEUS N alpha-acetyl-transferase, involved in acetylation of the N-terminal residues of histones H4 and H2A histone acetylation histone acetyltransferase activity nucleus|cytoplasm
YML016C YML016C PPZ1 hom Verified 2.10538721561743 0.0176288078646983 no 199 0.0257106044708102 115 NA FT PROTEIN LOCALIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS NUCLEUS|PLASMA MEMBRANE Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance cellular sodium ion homeostasis|cellular protein localization|protein dephosphorylation protein serine/threonine phosphatase activity extrinsic to plasma membrane|nucleus|cytoplasm
YDR077W YDR077W SED1 hom Verified 2.08700484999409 0.0184438480688573 no 200 0.0146180953845475 127 NA FT CELL WALL ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Major stress-induced structural GPI-cell wall glycoprotein in stationary-phase cells, associates with translating ribosomes, possible role in mitochondrial genome maintenance; ORF contains two distinct variable minisatellites fungal-type cell wall organization|mitochondrial genome maintenance structural constituent of cell wall mitochondrion|ribosome|fungal-type cell wall
YAL030W YAL030W SNC1 hom Verified 2.08647301609749 0.0184678985026891 no 201 0.0123499105052827 139 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|GOLGI APPARATUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; proposed to be involved in endocytosis; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC1 has a paralog, SNC2, that arose from the whole genome duplication endocytosis|exocytosis|Golgi to plasma membrane transport|vesicle fusion SNAP receptor activity SNARE complex|trans-Golgi network|endosome|transport vesicle membrane|plasma membrane|cellular bud neck
YFR055W_p YFR055W IRC7 hom Uncharacterized 2.08002041818223 0.0187618300550095 no 202 0.0224629116024434 142 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Beta-lyase involved in the production of thiols; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner and by copper levels in a Mac1-dependent manner sulfur compound metabolic process|L-cysteine catabolic process to pyruvate cysteine-S-conjugate beta-lyase activity cellular_component
YMR138W YMR138W CIN4 hom Verified 2.07847985207156 0.018832592361548 no 203 0.0238131616810493 176 NA FT SIGNALING GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; regulated by the GTPase-activating protein, Cin2p, the human retinitis pigmentosa 2 (RP2) homolog protein folding|tubulin complex assembly|tubulin complex biogenesis GTP binding cytoplasm
YER142C YER142C MAG1 hom Verified 2.07837366494314 0.0188374781734429 no 204 0.011570756546156 111 NA FT RESPONSE TO DNA DAMAGE NUCLEUS 3-methyl-adenine DNA glycosylase; involved in protecting DNA against alkylating agents; initiates base excision repair by removing damaged bases to create abasic sites that are subsequently repaired; protein abundance increases in response to DNA replication stress base-excision repair, AP site formation|DNA dealkylation involved in DNA repair alkylbase DNA N-glycosylase activity nucleus
YPL148C YPL148C PPT2 hom Verified 2.07678785135759 0.0189105719895922 no 205 0.050390871632678 251 NA FF|FT KETONE METABOLISM|LIPID METABOLISM MITOCHONDRION Phosphopantetheine:protein transferase (PPTase), activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation protein-cofactor linkage holo-[acyl-carrier-protein] synthase activity mitochondrion
YLR131C YLR131C ACE2 hom Verified 2.07470995759246 0.0190067119789303 no 206 0.0660377333073315 417 NA FF|FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CELL DIVISION NUCLEUS Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication Unknown|regulation of transcription involved in G1 phase of mitotic cell cycle RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding cytosol|nucleus
YNL119W YNL119W NCS2 hom Verified 2.05664745113145 0.0198600751591624 no 207 0.0200683780654431 125 NA FT RNA PROCESSING Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae tRNA wobble position uridine thiolation|pseudohyphal growth|protein urmylation|invasive growth in response to glucose limitation molecular_function cytosol|cytoplasm
YPL196W YPL196W OXR1 hom Verified 2.05366877361617 0.0200038804042209 no 208 0.0152886928301542 151 NA FT RESPONSE TO OXIDATIVE STRESS MITOCHONDRION Protein of unknown function required for normal levels of resistance to oxidative damage, null mutants are sensitive to hydrogen peroxide; member of a conserved family of proteins found in eukaryotes cellular response to oxidative stress molecular_function mitochondrion
YNR014W_p YNR014W YNR014W hom Uncharacterized 2.05274650312324 0.0200485846881537 no 209 0.0276341833950055 136 NA Putative protein of unknown function; expression is cell-cycle regulated, Azf1p-dependent, and heat-inducible; YNR014W has a paralog, YMR206W, that arose from the whole genome duplication biological_process molecular_function cytoplasm
YOR199W_d YOR199W YOR199W hom Dubious 2.04690174881386 0.0203338661816035 no 210 0.028859050144413 137 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YCR028C-A YCR028C-A RIM1 hom Verified 2.04559652607399 0.0203980417711888 no 211 0.0438963412327281 195 NA FT MITOCHONDRION ORGANIZATION MITOCHONDRION Single-stranded DNA-binding protein essential for mitochondrial genome maintenance; involved in mitochondrial DNA replication mitochondrial DNA replication|mitochondrial genome maintenance single-stranded DNA binding mitochondrial nucleoid|mitochondrion
YOR198C YOR198C BFR1 hom Verified 2.04411527420303 0.0204710802784982 no 212 0.0307749334200605 234 NA FT CELL CYCLE ENDOMEMBRANE SYSTEM Component of mRNP complexes associated with polyribosomes; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity meiosis|mRNA metabolic process|regulation of mitosis RNA binding ribonucleoprotein complex|polysome|nuclear outer membrane-endoplasmic reticulum membrane network
YNL005C YNL005C MRP7 hom Verified 2.04388995204658 0.0204822100019386 no 213 0.054725731640602 215 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome|peptidyltransferase activity mitochondrion|mitochondrial large ribosomal subunit
YGL118C_d YGL118C YGL118C hom Dubious 2.0415905721615 0.0205960806373467 no 214 0.0197539257902522 134 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGL159W_p YGL159W YGL159W hom Uncharacterized 2.04058885537052 0.0206458554251743 no 215 0.0278910561813998 174 NA Putative protein of unknown function; deletion mutant has no detectable phenotype biological_process molecular_function cellular_component
YLL029W YLL029W FRA1 hom Verified 2.04039145276832 0.0206556762660421 no 216 0.0269557787099693 165 NA FT TRANSCRIPTION FROM RNA POL II|PROTEOLYSIS Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; cytosolic; mutant fails to repress transcription of iron regulon and is defective in spore formation negative regulation of transcription from RNA polymerase II promoter in response to iron molecular_function cytosol|cytoplasm
YHR115C YHR115C DMA1 hom Verified 2.03661196631133 0.0208444713389434 no 217 0.0248718710416499 162 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION Ubiquitin-protein ligase (E3); controls septin dynamics and the spindle position checkpoint (SPOC) along with functionally redundant ligase Dma2p by regulating the recruitment of Elm1p to the bud neck; regulates levels of the translation initiation factor eIF2 subunit Gcd11p, as well as abundance, localization, and ubiquitination of Cdk inhibitory kinase Swe1p; ubiquitinates cyclin Pcl1p; ortholog of human RNF8 protein, similar to human Chfr; contains FHA and RING finger establishment of mitotic spindle orientation|protein autoubiquitination|septin ring assembly|mitotic cell cycle spindle assembly checkpoint ubiquitin-protein ligase activity cytoplasm
YMR294W YMR294W JNM1 hom Verified 2.0237804864256 0.0214963714329544 no 218 0.0375055750171273 261 NA FF|FT CELL CYCLE|CYTOSKELETON ORGANIZATION CYTOSKELETON Component of the yeast dynactin complex, consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B nuclear migration|establishment of mitotic spindle orientation structural constituent of cytoskeleton dynactin complex|cell cortex|spindle pole body|astral microtubule
YJL206C_p YJL206C YJL206C hom Uncharacterized 2.01632381963037 0.0218830628628954 no 219 0.0182859590134898 146 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Putative protein of unknown function; similar to transcriptional regulators from the Zn[2]-Cys[6] binuclear cluster protein family; mRNA is weakly cell cycle regulated, peaking in S phase; induced rapidly upon MMS treatment biological_process molecular_function cellular_component
YGR235C YGR235C MOS2 hom Verified 2.01614166766266 0.021892582012893 no 220 0.0258437908555525 137 NA FT MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial inner membrane protein; non-essential component of the mitochondrial inner membrane organizing system (MINOS, MitOS, or MICOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture cristae formation molecular_function mitochondrion|mitochondrial crista junction|integral to mitochondrial inner membrane
YER111C YER111C SWI4 hom Verified 2.00931831008652 0.0222516936562751 no 221 0.025018324983864 197 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE NUCLEUS|CHROMOSOME DNA binding component of the SBF complex (Swi4p-Swi6p); a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair; acetylation at two sites, K1016 and K1066, regulates interaction with Swi6p positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription involved in G1/S phase of mitotic cell cycle sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription SBF transcription complex|nuclear chromatin
YLR204W YLR204W QRI5 hom Verified 2.0056010265898 0.0224494161476679 no 222 0.0537064262368704 281 NA FF|FT RNA PROCESSING MITOCHONDRION Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA mRNA processing molecular_function mitochondrion|integral to mitochondrial inner membrane
YBR017C YBR017C KAP104 hom Verified 1.99895208410647 0.0228067692601426 no 223 0.0190151275283817 141 NA FT PROTEIN LOCALIZATION|CELL CYCLE SITE OF POLARIZED GROWTH Transportin or cytosolic karyopherin beta 2; functions in the rg-nuclear localization signal-mediated nuclear import/reimport of mRNA-binding proteins Nab2p and Hrp1p; regulates asymmetric protein synthesis in daughter cells during mitosis protein import into nucleus|cell cycle|mRNA-binding (hnRNP) protein import into nucleus|transcription factor import into nucleus nuclear localization sequence binding cytosol|integral to membrane|cellular bud neck|cellular bud tip
YLR048W YLR048W RPS0B hom Verified 1.98692651126982 0.0234652706174213 no 224 0.0159426643216644 133 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION RIBOSOME Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2 cytoplasmic translation|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA export from nucleus|ribosomal small subunit assembly|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit
YDR347W YDR347W MRP1 hom Verified 1.97921818109787 0.0238957233949139 no 225 0.0296070233229009 184 NA FT TRANSLATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit mitochondrial ribosomal protein mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YDR291W YDR291W HRQ1 hom Verified 1.97054586660354 0.0243879218698279 no 226 0.0192598941786393 132 NA FT NUCLEUS 3'-5'DNA helicase that has DNA strand annealing activity; helicase activity is stimulated by fork structure and 3'-tail length of substrates; belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity; similar to the human RecQ4p implicated in Rothmund-Thomson syndrome(RTS) biological_process molecular_function nucleus
YML061C YML061C PIF1 hom Verified 1.96794286093818 0.0245373062442911 no 227 0.0376719175791588 242 NA FT RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION NUCLEUS|MITOCHONDRION DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells chromosome organization|negative regulation of telomere maintenance via telomerase|telomere maintenance|mitochondrial genome maintenance|DNA recombination DNA helicase activity|telomerase inhibitor activity mitochondrion|nucleus|mitochondrial membrane
YBR042C YBR042C CST26 hom Verified 1.96541296514178 0.0246832300517039 no 228 0.0216513217657644 161 NA FT LIPID METABOLISM Putative transferase involved in phospholipid biosynthesis; required for incorporation of stearic acid into phosphatidylinositol; affects chromosome stability when overexpressed; CST26 has a paralog, YDR018C, that arose from the whole genome duplication phospholipid biosynthetic process transferase activity, transferring acyl groups lipid particle
YKL169C_d YKL169C YKL169C hom Dubious 1.96109934318828 0.0249337176739231 no 229 0.0567356811025002 267 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL38 Unknown Unknown Unknown
YER122C YER122C GLO3 hom Verified 1.95624309253246 0.0252182621958747 no 230 0.0266786671054325 160 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|NUCLEOTIDE METABOLISM ENDOMEMBRANE SYSTEM|GOLGI APPARATUS ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Gcs1p retrograde vesicle-mediated transport, Golgi to ER|COPI coating of Golgi vesicle|ER to Golgi vesicle-mediated transport ARF GTPase activator activity COPI-coated vesicle|endoplasmic reticulum-Golgi intermediate compartment|COPI vesicle coat
YBR048W YBR048W RPS11B hom Verified 1.956142641422 0.025224176579861 no 231 0.0303824707357503 175 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11B has a paralog, RPS11A, that arose from the whole genome duplication cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal small subunit assembly structural constituent of ribosome cytosolic small ribosomal subunit|90S preribosome
YDR316W YDR316W OMS1 hom Verified 1.95391604719321 0.0253555732319 no 232 0.0388164239935274 215 NA FT MITOCHONDRION Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif; multicopy suppressor of respiratory defects caused by OXA1 mutations biological_process S-adenosylmethionine-dependent methyltransferase activity mitochondrial envelope|mitochondrion
YLR270W YLR270W DCS1 hom Verified 1.95353707923815 0.0253779940384586 no 233 0.032012512020307 178 NA FT NUCLEUS|MITOCHONDRION Non-essential hydrolase involved in mRNA decapping; activates Xrn1p; may function in a feedback mechanism to regulate deadenylation, contains pyrophosphatase activity and a HIT (histidine triad) motif; interacts with neutral trehalase Nth1p; required for growth on glycerol medium; protein abundance increases in response to DNA replication stress deadenylation-dependent decapping of nuclear-transcribed mRNA|positive regulation of nuclease activity|nuclear-transcribed mRNA catabolic process, deadenylation-independent decay hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|enzyme activator activity|m7G(5')pppN diphosphatase activity mitochondrion|nucleus|cytoplasmic mRNA processing body|cytoplasm
YLR165C YLR165C PUS5 hom Verified 1.95081941869651 0.025539265504279 no 234 0.0282029906265408 161 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS MITOCHONDRION Pseudouridine synthase, catalyzes only the formation of pseudouridine (Psi)-2819 in mitochondrial 21S rRNA; not essential for viability rRNA modification|pseudouridine synthesis pseudouridylate synthase activity mitochondrion
YER185W YER185W PUG1 hom Verified 1.94367486733917 0.0259673356113504 no 235 0.0258208998769539 164 NA FT PLASMA MEMBRANE Plasma membrane protein with roles in the uptake of protoprophyrin IX and the efflux of heme; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of proteins heme transport molecular_function integral to membrane|plasma membrane
YHR136C YHR136C SPL2 hom Verified 1.93791013919047 0.0263170933723635 no 236 0.0292542701853397 165 NA Protein with similarity to cyclin-dependent kinase inhibitors; downregulates low-affinity phosphate transport during phosphate limitation; overproduction suppresses a plc1 null mutation; GFP-fusion protein localizes to the cytoplasm response to temperature stimulus enzyme inhibitor activity cytoplasm
YLR200W YLR200W YKE2 hom Verified 1.93348869539579 0.0265880121762581 no 237 0.0502022023344803 275 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS NUCLEUS Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin protein folding|tubulin complex assembly tubulin binding prefoldin complex|cytoplasm
YGR221C YGR221C TOS2 hom Verified 1.93008154815922 0.0267983671684224 no 238 0.0217926492729955 167 NA FT CELL DIVISION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Protein involved in localization of Cdc24p to the site of bud growth; may act as a membrane anchor; localizes to the bud neck and bud tip; potentially phosphorylated by Cdc28p budding cell bud growth molecular_function cellular bud neck|cellular bud tip
YPL004C YPL004C LSP1 hom Verified 1.92351463454388 0.0272077251894391 no 239 0.02159539673419 105 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION MITOCHONDRION Primary component of eisosomes, which are large immobile patch structures at the cell cortex associated with endocytosis, along with Pil1p and Sur7p; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; member of the BAR domain family negative regulation of protein kinase activity|endocytosis|response to heat lipid binding mitochondrial outer membrane|eisosome|mitochondrion|plasma membrane|cytoplasm
YCR073W-A YCR073W-A SOL2 hom Verified 1.9209385496913 0.027369727516969 no 240 0.0332372931851783 208 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|RNA LOCALIZATION|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL2 has a paralog, SOL1, that arose from the whole genome duplication tRNA export from nucleus molecular_function|6-phosphogluconolactonase activity cytosol|cytoplasm
YBL090W YBL090W MRP21 hom Verified 1.92044957520445 0.0274005683317146 no 241 0.0430326718511952 217 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit; MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences mitochondrial translational initiation|mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YGL148W YGL148W ARO2 hom Verified 1.91328947674962 0.0278555020800643 no 242 0.0870506960973267 424 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM Bifunctional chorismate synthase and flavin reductase; catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids; protein abundance increases in response to DNA replication stress aromatic amino acid family biosynthetic process chorismate synthase activity|riboflavin reductase (NADPH) activity cytoplasm
YGL228W YGL228W SHE10 hom Verified 1.91283790784307 0.0278844032802204 no 243 0.0261172956788981 160 NA FT MITOCHONDRION Putative glycosylphosphatidylinositol (GPI)-anchored protein of unknown function; overexpression causes growth arrest biological_process molecular_function cellular_component
YMR119W-A_d YMR119W-A YMR119W-A hom Dubious 1.90926556160314 0.0281139212622719 no 244 0.0276518779024591 146 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YBL022C YBL022C PIM1 hom Verified 1.90793398348834 0.0281998746534644 no 245 0.0526302594126731 281 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION|RESPONSE TO OXIDATIVE STRESS MITOCHONDRION ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria chaperone-mediated protein complex assembly|misfolded or incompletely synthesized protein catabolic process ATP-dependent peptidase activity mitochondrion|mitochondrial matrix
YBR020W YBR020W GAL1 hom Verified 1.90477941453185 0.0284043754295252 no 246 0.0259085734109471 177 NA FT CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; GAL1 has a paralog, GAL3, that arose from the whole genome duplication galactose catabolic process via UDP-galactose|carbohydrate phosphorylation|positive regulation of transcription by galactose galactokinase activity cytoplasm
YHR146W YHR146W CRP1 hom Verified 1.90441727853754 0.0284279303295194 no 247 0.0369270475469197 213 NA FT NUCLEUS Protein that binds to cruciform DNA structures biological_process DNA binding nucleus
YNL275W YNL275W BOR1 hom Verified 1.9007588650173 0.0286668021543665 no 248 0.0274654684711364 153 NA FT PROTEIN LOCALIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT PLASMA MEMBRANE Boron efflux transporter of the plasma membrane; binds HCO3-, I-, Br-, NO3- and Cl-; has similarity to the characterized boron efflux transporter A. thaliana BOR1 borate transport|protein targeting to vacuole borate efflux transmembrane transporter activity integral to membrane|plasma membrane|fungal-type vacuole
YJL023C YJL023C PET130 hom Verified 1.89812374359663 0.0288398915375612 no 249 0.027047071492628 149 NA FT MITOCHONDRION Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YPL174C YPL174C NIP100 hom Verified 1.89085064501729 0.0293221421891052 no 250 0.0392098091145116 235 NA FT CELL CYCLE|CYTOSKELETON ORGANIZATION CYTOSKELETON Large subunit of the dynactin complex, which is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued) establishment of mitotic spindle orientation microtubule binding dynactin complex|cell cortex|spindle pole body|astral microtubule
YOL152W YOL152W FRE7 hom Verified 1.88865326748921 0.029469152194977 no 251 0.0304370022246158 162 NA FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY PLASMA MEMBRANE Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels iron ion transport|copper ion import ferric-chelate reductase activity integral to membrane|plasma membrane
YBR106W YBR106W PHO88 hom Verified 1.88403270052227 0.0297802761844096 no 252 0.0842642228149849 447 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations phosphate ion transport molecular_function mitochondrion|membrane
YMR303C YMR303C ADH2 hom Verified 1.88348046602801 0.0298176423200905 no 253 0.029900773879677 162 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1 ethanol metabolic process|NADH oxidation|fermentation|amino acid catabolic process to alcohol via Ehrlich pathway alcohol dehydrogenase (NAD) activity cytoplasm
YCR082W YCR082W AHC2 hom Verified 1.88292630736434 0.0298551777409646 no 254 0.040997843879611 226 NA FT CHROMATIN ORGANIZATION NUCLEUS HISTONE ACETYLTRANSFERASE Component of the ADA histone acetyltransferase complex; Ach2p and Ach1p are unique to the ADA complex and not shared with the related SAGA and SLIK complexes; may tether Ach1p to the complex histone acetylation histone acetyltransferase activity Ada2/Gcn5/Ada3 transcription activator complex|nucleus|cytoplasm
YML071C YML071C COG8 hom Verified 1.86960914353335 0.0307690573077806 no 255 0.165388545728439 655 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments intra-Golgi vesicle-mediated transport|CVT pathway molecular_function Golgi transport complex
YGR081C YGR081C SLX9 hom Verified 1.86944191743248 0.0307806786750453 no 256 0.0445082510332323 212 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Protein required for pre-rRNA processing; associated with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function preribosome, small subunit precursor|nucleolus|nucleus|90S preribosome
YDR451C YDR451C YHP1 hom Verified 1.86696659176847 0.0309531266819615 no 257 0.0636458967575949 306 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE NUCLEUS|CHROMOSOME Homeobox transcriptional repressor; binds Mcm1p and early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval; YHP1 has a paralog, YOX1, that arose from the whole genome duplication negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription involved in G1 phase of mitotic cell cycle RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription nuclear chromatin|nucleus
YGL236C YGL236C MTO1 hom Verified 1.86166159014596 0.0313254029415071 no 258 0.0407560176836289 186 NA FT RNA PROCESSING|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants mitochondrial tRNA wobble uridine modification molecular_function mitochondrion
YBR009C YBR009C HHF1 hom Verified 1.8522062059904 0.0319981089830179 no 259 0.0327778870756194 215 NA FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Histone H4, core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity chromatin assembly or disassembly|sexual sporulation resulting in formation of a cellular spore|histone H3-K79 methylation DNA binding replication fork protection complex|nuclear nucleosome
YJR115W_p YJR115W YJR115W hom Uncharacterized 1.85183764826056 0.0320245698317 no 260 0.0234410029499282 142 NA Putative protein of unknown function; YJR115W has a paralog, ECM13, that arose from the whole genome duplication biological_process molecular_function cellular_component
YNL257C YNL257C SIP3 hom Verified 1.85132157946077 0.0320616516972176 no 261 0.0451418337356478 247 NA FT TRANSCRIPTION FROM RNA POL II Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog, YSP1, that arose from the whole genome duplication positive regulation of transcription from RNA polymerase II promoter transcription cofactor activity integral to membrane
YDR237W YDR237W MRPL7 hom Verified 1.84760652112345 0.0323296428270454 no 262 0.0445656275338264 240 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YPR197C_d YPR197C YPR197C hom Dubious 1.84639633244947 0.0324173396817094 no 263 0.0801554007339353 384 NA FF Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPR036W YPR036W VMA13 hom Verified 1.84351498404683 0.0326269280103269 no 264 0.075885453310226 296 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Subunit H of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; serves as an activator or a structural stabilizer of the V-ATPase vacuolar acidification proton-transporting ATPase activity, rotational mechanism vacuolar proton-transporting V-type ATPase, V1 domain|fungal-type vacuole membrane|integral to membrane
YNL087W YNL087W TCB2 hom Verified 1.84281343815287 0.0326781270451846 no 265 0.0356771057601252 187 NA FT ENDOPLASMIC RETICULUM|PLASMA MEMBRANE ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains 3 calcium and lipid binding domains; mRNA is targeted to the bud biological_process lipid binding cellular bud|cortical endoplasmic reticulum
YBR114W YBR114W RAD16 hom Verified 1.84229322277862 0.0327161352865048 no 266 0.0351452448592384 197 NA FT RESPONSE TO DNA DAMAGE|PROTEOLYSIS NUCLEUS UBIQUITIN LIGASE COMPLEX Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex nucleotide-excision repair, DNA damage recognition|protein ubiquitination involved in ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity|damaged DNA binding|DNA-dependent ATPase activity nucleotide-excision repair factor 4 complex|Cul3-RING ubiquitin ligase complex
YDL101C YDL101C DUN1 hom Verified 1.84188436076552 0.0327460333480769 no 267 0.0413149034974156 268 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION NUCLEUS Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; also regulates postreplicative DNA repair protein phosphorylation|replication fork protection|cell cycle checkpoint|DNA damage checkpoint protein kinase activity nucleus
YML012C-A_d YML012C-A YML012C-A hom Dubious 1.84076269560715 0.0328281708777183 no 268 0.041714774831178 277 NA FF Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SEL1 Unknown Unknown Unknown
YLR137W YLR137W RKM5 hom Verified 1.83820405616029 0.0330161711670935 no 269 0.0213342087106593 135 NA Protein lysine methyltransferase; monomethylates Lys-46 of the ribosomal large subunit Rpl1a/Rpl1b; member of the seven beta-strand methyltransferase superfamily; orthologs only found among fungal species protein methylation S-adenosylmethionine-dependent methyltransferase activity cellular_component
YMR316C-A_p YMR316C-A YMR316C-A hom Uncharacterized 1.83797389036171 0.0330331263887353 no 270 0.0290462953406491 191 NA Protein of unknown function; mRNA identified as translated by ribosome profiling data; overlaps the verified gene DIA1/YMR316W biological_process molecular_function cellular_component
YPL051W YPL051W ARL3 hom Verified 1.83611750691642 0.0331701398047334 no 271 0.0599789527039282 346 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING ENDOMEMBRANE SYSTEM|GOLGI APPARATUS GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor intracellular protein transport|Golgi to plasma membrane protein transport|protein localization to organelle GTPase activity Golgi apparatus|nuclear outer membrane-endoplasmic reticulum membrane network
YDR137W YDR137W RGP1 hom Verified 1.83487307356095 0.0332622490856831 no 272 0.103279505619801 380 NA FF|FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|CELL DIVISION ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p retrograde transport, endosome to Golgi guanyl-nucleotide exchange factor activity Golgi apparatus|Ric1p-Rgp1p complex|Golgi membrane|guanyl-nucleotide exchange factor complex
YGL088W_d YGL088W YGL088W hom Dubious 1.8335546291467 0.03336006617101 no 273 0.0366341154617674 191 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps snR10, a snoRNA required for preRNA processing Unknown Unknown Unknown
YGL082W_p YGL082W YGL082W hom Uncharacterized 1.83200718156069 0.0334751753329669 no 274 0.0200361559737101 138 NA FT NUCLEUS Putative protein of unknown function; predicted prenylation/proteolysis target of Afc1p and Rce1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YGL082W is not an essential gene biological_process molecular_function nucleus|plasma membrane|cytoplasm
YHR051W YHR051W COX6 hom Verified 1.83079221802418 0.0335657811598714 no 275 0.0307248159477463 196 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Subunit VI of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; expression is regulated by oxygen levels mitochondrial electron transport, cytochrome c to oxygen cytochrome-c oxidase activity mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YLR187W YLR187W SKG3 hom Verified 1.82905993276 0.0336953152146068 no 276 0.0324106523366974 159 NA FT SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate; similar to Skg4p; relocalizes from bud neck to cytoplasm upon DNA replication stress; SKG3 has a paralog, CAF120, that arose from the whole genome duplication biological_process molecular_function cellular bud|cellular bud neck|cytoplasm
YML094C-A_d YML094C-A YML094C-A hom Dubious 1.8286106067182 0.0337289813026038 no 277 0.0418352278059985 273 NA FF Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene GIM5/YML094W; deletion confers sensitivity to GSAO Unknown Unknown Unknown
YDR136C_d YDR136C VPS61 hom Dubious 1.82734329209124 0.0338240849415807 no 278 0.127984143875458 449 NA FF Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 4% of ORF overlaps the verified gene RGP1; deletion causes a vacuolar protein sorting defect Unknown Unknown Unknown
YOR201C YOR201C MRM1 hom Verified 1.82298933522505 0.0341525030794076 no 279 0.04049719720149 235 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS MITOCHONDRION Ribose methyltransferase that modifies a functionally critical, conserved nucleotide in mitochondrial 21S rRNA rRNA modification rRNA (guanine-N1-)-methyltransferase activity mitochondrion
YJL187C YJL187C SWE1 hom Verified 1.82166673484309 0.034252784151714 no 280 0.0267107898001598 170 NA FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION NUCLEUS|SITE OF POLARIZED GROWTH Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate negative regulation of spindle pole body separation|G2/M transition size control checkpoint|protein phosphorylation|re-entry into mitotic cell cycle|G2/M transition of mitotic cell cycle|cell shape checkpoint|regulation of cyclin-dependent protein kinase activity|regulation of cell size|regulation of meiosis protein tyrosine kinase activity|protein kinase activity nucleus|cellular bud neck
YBR164C YBR164C ARL1 hom Verified 1.8202810233663 0.0343581098782909 no 281 0.0906542473590626 414 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|VACUOLAR TRANSPORT GOLGI APPARATUS Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor Golgi to plasma membrane protein transport|vesicle-mediated transport|protein targeting to vacuole GTPase activity trans-Golgi network|cytosol|Golgi apparatus
YGL080W YGL080W FMP37 hom Verified 1.81405716943007 0.0348344623265275 no 282 0.0304388312375723 202 NA FT MITOCHONDRION Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; null mutant displays slow growth that is complemented by expression of human or mouse ortholog; mutation in human ortholog is associated with lactic acidosis and hyperpyruvatemia mitochondrial pyruvate transport pyruvate transmembrane transporter activity mitochondrion|integral to mitochondrial inner membrane
YMR068W YMR068W AVO2 hom Verified 1.80811076761289 0.0352946313362665 no 283 0.0371806455640576 172 NA FT SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION PLASMA MEMBRANE Component of a complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth fungal-type cell wall organization|TOR signaling cascade|regulation of cell growth|establishment or maintenance of actin cytoskeleton polarity molecular_function TORC2 complex|cytoplasm
YPL269W YPL269W KAR9 hom Verified 1.79426624315158 0.0363853416879089 no 284 0.0586224339676156 307 NA FT NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase nuclear migration along microtubule|establishment of spindle localization molecular_function cell cortex|spindle pole body|mating projection tip
YPL180W YPL180W TCO89 hom Verified 1.79316343794229 0.0364733972072716 no 285 0.0505001610392501 283 NA FT SIGNALING|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM PLASMA MEMBRANE Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p), a complex that regulates growth in response to nutrient availability; cooperates with Ssd1p in the maintenance of cellular integrity; deletion strains are hypersensitive to rapamycin TOR signaling cascade|fungal-type cell wall organization|response to salt stress|regulation of cell growth|glycerol metabolic process molecular_function TORC1 complex|fungal-type vacuole membrane|extrinsic to internal side of plasma membrane|extrinsic to vacuolar membrane
YGR040W YGR040W KSS1 hom Verified 1.79058176293526 0.0366802178727555 no 286 0.028229733610033 188 NA FT CELL CYCLE|SIGNALING|PROTEIN PHOSPHORYLATION NUCLEUS Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains pheromone-dependent signal transduction involved in conjugation with cellular fusion|signal transduction involved in filamentous growth|negative regulation of sequence-specific DNA binding transcription factor activity|protein phosphorylation|invasive growth in response to glucose limitation MAP kinase activity|protein kinase activity|transcription factor binding nucleus
YPL260W YPL260W YPL260W hom Verified 1.78891600415934 0.0368141719733398 no 287 0.0516475170164563 244 NA FT NUCLEUS Putative substrate of cAMP-dependent protein kinase (PKA); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YPL260W is not an essential gene; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus|cytoplasm
YPL079W YPL079W RPL21B hom Verified 1.78508545107759 0.0371237287392715 no 288 0.0329007374691975 197 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L21B; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21B has a paralog, RPL21A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YER004W YER004W FMP52 hom Verified 1.78457747695583 0.0371649387134054 no 289 0.0455966746656761 194 NA FT ENDOPLASMIC RETICULUM|MITOCHONDRION Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation biological_process molecular_function mitochondrial outer membrane|mitochondrion|endoplasmic reticulum
YNL184C_p YNL184C YNL184C hom Uncharacterized 1.78404408356888 0.0372082510812679 no 290 0.0550847753977079 285 NA Protein of unknown function; expressed at both mRNA and protein levels biological_process molecular_function cellular_component
YMR032W YMR032W HOF1 hom Verified 1.78082736775757 0.0374703285208531 no 291 0.0391946000199185 292 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION SITE OF POLARIZED GROWTH|CYTOSKELETON Bud neck-localized, SH3 domain-containing protein required for cytokinesis; is phosphorylated by Dbf2p; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p cytokinesis after mitosis|barrier septum assembly involved in cell cycle cytokinesis|response to DNA damage stimulus|cytokinesis cytoskeletal protein binding cellular bud neck contractile ring|cellular bud neck septin ring
YMR275C YMR275C BUL1 hom Verified 1.78031905858724 0.0375118799065935 no 292 0.0458346052159339 255 NA FT MITOCHONDRION ORGANIZATION PLASMA MEMBRANE UBIQUITIN LIGASE COMPLEX Ubiquitin-binding component of the Rsp5p E3-ubiquitin ligase complex; disruption causes temperature-sensitive growth, overexpression causes missorting of amino acid permeases; BUL1 has a paralog, BUL2, that arose from the whole genome duplication mitochondrion inheritance|protein monoubiquitination|protein polyubiquitination ubiquitin-ubiquitin ligase activity ubiquitin ligase complex|plasma membrane
YOR273C YOR273C TPO4 hom Verified 1.77807090531913 0.0376961051060607 no 293 0.0631530486876933 338 NA FF|FT PLASMA MEMBRANE Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane spermidine transport|spermine transport spermidine transmembrane transporter activity|spermine transmembrane transporter activity fungal-type vacuole membrane|integral to membrane|plasma membrane
YNR007C YNR007C ATG3 hom Verified 1.77457151577982 0.0379843319607378 no 294 0.0365503029623344 218 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS E2-like enzyme involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; plays a role in formation of Atg8p-phosphatidylethanolamine conjugates, which are involved in membrane dynamics during autophagy and Cvt; interaction with Atg8p is regulated by its acetylation by Esa1p (catalytic subunit of NuA4 histone acetyltransferase complex) while attenuation of Atg3 acetylation is mediated by histone deacetylase Rpd3p C-terminal protein lipidation|piecemeal microautophagy of nucleus|mitochondrion degradation|CVT pathway|autophagic vacuole assembly Atg8 ligase activity cytosol|cytoplasm
YOR164C YOR164C GET4 hom Verified 1.77411956804952 0.0380216873415665 no 295 0.0502543881643262 213 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Mdy2p; highly conserved across species and homologous to human gene C7orf20 protein insertion into ER membrane|posttranslational protein targeting to membrane molecular_function TRC complex|cytoplasm
YLR345W_p YLR345W YLR345W hom Uncharacterized 1.7730558576149 0.0381097257664296 no 296 0.0409300440958434 194 NA FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Similar to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase enzymes responsible for the metabolism of fructoso-2,6-bisphosphate; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene regulation of glycolysis|fructose 2,6-bisphosphate metabolic process 6-phosphofructo-2-kinase activity cytoplasm
YOR108W YOR108W LEU9 hom Verified 1.77082179789073 0.0382951699650233 no 297 0.0339630810606942 182 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Alpha-isopropylmalate synthase II (2-isopropylmalate synthase); catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant; LEU9 has a paralog, LEU4, that arose from the whole genome duplication leucine biosynthetic process 2-isopropylmalate synthase activity mitochondrion
YMR230W YMR230W RPS10B hom Verified 1.76724117004069 0.0385939237730988 no 298 0.0444190802084085 204 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10B has a paralog, RPS10A, that arose from the whole genome duplication cytoplasmic translation|rRNA export from nucleus structural constituent of ribosome cytosolic small ribosomal subunit
YDR444W_p YDR444W YDR444W hom Uncharacterized 1.76400838712167 0.0388652835660414 no 299 0.0402194820374895 209 NA FT LIPID METABOLISM Putative hydrolase acting on ester bonds biological_process molecular_function cytoplasm
YMR163C YMR163C INP2 hom Verified 1.76047031498519 0.0391640481932295 no 300 0.0333501343051424 188 NA FT PEROXISOME ORGANIZATION Peroxisome-specific receptor important for peroxisome inheritance; co-fractionates with peroxisome membranes and co-localizes with peroxisomes in vivo; physically interacts with the myosin V motor Myo2p; INP2 is not an essential gene peroxisome inheritance protein anchor peroxisome|integral to peroxisomal membrane|cytoplasm
YGR252W YGR252W GCN5 hom Verified 1.75948156688657 0.0392478742158684 no 301 0.101461939699802 434 NA FF|FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME HISTONE ACETYLTRANSFERASE Acetyltransferase, modifies N-terminal lysines on histones H2B and H3; acetylates Rsc4p, a subunit of the RSC chromatin-remodeling complex, altering replication stress tolerance; catalytic subunit of the ADA and SAGA histone acetyltransferase complexes; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; greater involvement in repression of RNAPII-dependent transcription than in activation histone acetylation|regulation of transcription by chromatin organization|chromatin modification|positive regulation of transcription elongation from RNA polymerase II promoter histone acetyl-lysine binding|transcription coactivator activity|histone acetyltransferase activity|H3 histone acetyltransferase activity SLIK (SAGA-like) complex|chromosome, centromeric region|Ada2/Gcn5/Ada3 transcription activator complex|SAGA complex
YEL063C YEL063C CAN1 hom Verified 1.75602862533144 0.0395417604657767 no 302 0.0528852746452432 274 NA FT MITOCHONDRION|PLASMA MEMBRANE Plasma membrane arginine permease; requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; CAN1 has a paralog, ALP1, that arose from the whole genome duplication basic amino acid transport|transmembrane transport basic amino acid transmembrane transporter activity|arginine transmembrane transporter activity mitochondrion|integral to membrane|membrane raft|plasma membrane
YDR179W-A_p YDR179W-A YDR179W-A hom Uncharacterized 1.75433631274393 0.0396864485428618 no 303 0.0390821864211066 192 NA Putative protein of unknown function biological_process molecular_function cellular_component
YLR144C YLR144C ACF2 hom Verified 1.74773280319196 0.040255152917237 no 304 0.0382369818472355 158 NA FT CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION Intracellular beta-1,3-endoglucanase; expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly; protein abundance increases in response to DNA replication stress actin cytoskeleton organization glucan endo-1,3-beta-D-glucosidase activity intracellular
YPR167C YPR167C MET16 hom Verified 1.74749672980345 0.0402756058341871 no 305 0.0370233605313587 181 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS 3'-phosphoadenylsulfate reductase, reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)|sulfur amino acid metabolic process phosphoadenylyl-sulfate reductase (thioredoxin) activity cytoplasm
YEL072W YEL072W RMD6 hom Verified 1.74548618382137 0.0404501376769125 no 306 0.0418428750552483 197 NA FT CELL CYCLE Protein required for sporulation biological_process molecular_function cellular_component
YHR111W YHR111W UBA4 hom Verified 1.74400246818591 0.0405793297270215 no 307 0.0512080751085478 272 NA FT RNA PROCESSING|CELL DIVISION|RESPONSE TO OXIDATIVE STRESS Protein that activates Urm1p before its conjugation to proteins (urmylation); also acts in thiolation of the wobble base of cytoplasmic tRNAs by adenylating and then thiolating Urm1p; receives sulfur from Tum1p cellular response to oxidative stress|tRNA wobble position uridine thiolation|cell budding|protein urmylation|tRNA thio-modification|Unknown|invasive growth in response to glucose limitation URM1 activating enzyme activity|sulfurtransferase activity|thiosulfate sulfurtransferase activity|protein adenylyltransferase activity cytoplasm
YDR533C YDR533C HSP31 hom Verified 1.74219169286985 0.0407374535495768 no 308 0.0618963624773864 269 NA FT PROTEOLYSIS Possible chaperone and cysteine protease; has similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site; protein abundance increases in response to DNA replication stress biological_process unfolded protein binding|cysteine-type peptidase activity cellular_component
YGL027C YGL027C CWH41 hom Verified 1.73055599292626 0.0417654931889234 no 309 0.058489812590598 226 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Processing alpha glucosidase I, ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress fungal-type cell wall biogenesis|protein N-linked glycosylation mannosyl-oligosaccharide glucosidase activity endoplasmic reticulum membrane
YJL051W YJL051W IRC8 hom Verified 1.72781295516059 0.0420108819853571 no 310 0.0239735920614958 137 NA Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52p foc mitotic recombination molecular_function integral to membrane|cellular bud
YNL089C_d YNL089C YNL089C hom Dubious 1.72720304812229 0.0420656018116588 no 311 0.039627321013045 249 NA Dubious open reading frame unlikely to encode a functional protein; almost completely overlaps YNL090W/RHO2 which encodes a small GTPase of the Rho/Rac subfamily of Ras-like proteins Unknown Unknown Unknown
YGL042C_d YGL042C YGL042C hom Dubious 1.72552234498406 0.0422166902182111 no 312 0.0421878367154445 207 NA Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene DST1 Unknown Unknown Unknown
YDL093W YDL093W PMT5 hom Verified 1.72415318105998 0.0423400968095954 no 313 0.0454847904691496 183 NA FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt3p, can instead interact with Pmt2p in some conditions; target for new antifungals protein O-linked mannosylation dolichyl-phosphate-mannose-protein mannosyltransferase activity integral to membrane|dolichyl-phosphate-mannose-protein mannosyltransferase complex
YDL025C YDL025C RTK1 hom Verified 1.72059393433464 0.0426622674602571 no 314 0.0722793141103846 272 NA FT PROTEIN PHOSPHORYLATION Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance increases in response to DNA replication stress biological_process protein serine/threonine kinase activity|protein kinase activity cellular_component
YGL013C YGL013C PDR1 hom Verified 1.72052604812126 0.0426684314921804 no 315 0.14045404186783 592 NA FF|FT TRANSCRIPTION FROM RNA POL II NUCLEUS RSC COMPLEX Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication Unknown|positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YGR085C YGR085C RPL11B hom Verified 1.71986402392868 0.0427285806909347 no 316 0.0573562815470899 230 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal 60S subunit protein L11B; expressed at half the level of Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of 60S proteins and RNA; homologous to mammalian ribosomal protein L11 and bacterial L5; RPL11B has a paralog, RPL11A, that arose from the whole genome duplication cytoplasmic translation|ribosomal large subunit assembly structural constituent of ribosome cytosolic large ribosomal subunit
YAL026C YAL026C DRS2 hom Verified 1.71814469215433 0.0428851133554491 no 317 0.0590465410731548 316 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RIBOSOME BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS GOLGI APPARATUS Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation and endocytosis; mutations in human homolog ATP8B1 result in liver disease intracellular protein transport|post-Golgi vesicle-mediated transport|phospholipid translocation|endocytosis|ribosomal small subunit assembly phospholipid-translocating ATPase activity trans-Golgi network|integral to membrane
YKL146W YKL146W AVT3 hom Verified 1.71782810544901 0.0429139867335113 no 318 0.0441601964737687 191 NA FT VACUOLAR TRANSPORT Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters amino acid export from vacuole transporter activity|L-glutamine transmembrane transporter activity|L-isoleucine transmembrane transporter activity|L-tyrosine transmembrane transporter activity fungal-type vacuole membrane|integral to membrane
YDR532C YDR532C KRE28 hom Verified 1.71757121365791 0.0429374273522682 no 319 0.0624787398876839 198 NA FT ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME|CYTOSKELETON KINETOCHORE Subunit of a kinetochore-microtubule binding complex with Spc105p that bridges centromeric heterochromatin and kinetochore MAPs and motors, and is also required for sister chromatid bi-orientation and kinetochore binding of SAC components biological_process molecular_function chromosome, centromeric region|condensed nuclear chromosome kinetochore|spindle pole body
YOR141C YOR141C ARP8 hom Verified 1.71449849957269 0.0432186061995809 no 320 0.0483969936118007 298 NA FT CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME|CYTOSKELETON Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes; has mRNA binding activity mitotic recombination|response to DNA damage stimulus|chromatin remodeling mRNA binding|ATP-dependent 3'-5' DNA helicase activity nucleus|Ino80 complex
YDR121W YDR121W DPB4 hom Verified 1.71285831476973 0.0433693043815251 no 321 0.0587520490347037 229 NA FT GENE SILENCING NUCLEUS|CHROMOSOME Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization DNA-dependent DNA replication|chromatin silencing at telomere double-stranded DNA binding|single-stranded DNA binding|DNA-directed DNA polymerase activity chromatin accessibility complex|epsilon DNA polymerase complex
YDL137W YDL137W ARF2 hom Verified 1.71162919645352 0.0434825121312976 no 322 0.047538567515046 232 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|RESPONSE TO NUTRIENT LEVELS GOLGI APPARATUS ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; ARF2 has a paralog, ARF1, that arose from the whole genome duplication ER to Golgi vesicle-mediated transport|macroautophagy|intra-Golgi vesicle-mediated transport GTPase activity cytosol|Golgi-associated vesicle
YDR363W YDR363W ESC2 hom Verified 1.70949289712 0.0436798431493546 no 323 0.0544993836556783 231 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|GENE SILENCING NUCLEUS Sumo-like domain protein; prevents accumulation of toxic intermediates during replication-associated recombinational repair; roles in silencing, lifespan, chromatid cohesion and the intra-S-phase DNA damage checkpoint; RENi family member intra-S DNA damage checkpoint|double-strand break repair via homologous recombination|chromatin silencing at silent mating-type cassette|mitotic sister chromatid cohesion molecular_function nucleus
YKL090W YKL090W CUE2 hom Verified 1.70729526293146 0.0438835930732143 no 324 0.0389722164483947 206 NA Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination biological_process ubiquitin binding cellular_component
YLR122C_d YLR122C YLR122C hom Dubious 1.69288935232775 0.0452382652186633 no 325 0.0459295759630775 201 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C Unknown Unknown Unknown
YGL205W YGL205W POX1 hom Verified 1.6863153126648 0.0458675416094861 no 326 0.0267461808639473 151 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix fatty acid beta-oxidation using acyl-CoA oxidase|fatty acid beta-oxidation acyl-CoA oxidase activity peroxisomal matrix
YIR002C YIR002C MPH1 hom Verified 1.68568817256722 0.0459279380708009 no 327 0.0512540285446311 243 NA FT RESPONSE TO DNA DAMAGE NUCLEUS 3'-5' DNA helicase involved in error-free bypass of DNA lesions; binds to flap DNA in an error-free bypass pathway and stimulates the activity of Rad27p and Dna2p; also involved in interstrand cross-link repair mutations confer a mutator phenotype; similarity to FANCM, a human Fanconi anemia complementation group protein that along with the MHF complex is involved in stabilizing and remodeling blocked replication forks; member of the SF2 DExD/H superfamily of helicases negative regulation of strand invasion|recombinational repair|DNA replication, Okazaki fragment processing flap-structured DNA binding|3'-5' DNA helicase activity nucleus
YFL007W YFL007W BLM10 hom Verified 1.68566213643921 0.0459304468498897 no 328 0.0449828878189029 245 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS NUCLEUS Proteasome activator; binds the core proteasome and stimulates proteasome-mediated protein degradation by inducing gate opening; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200 proteasome assembly|regulation of proteasomal protein catabolic process proteasome binding|peptidase activator activity proteasome core complex|proteasome complex|integral to membrane|nucleus
YKR098C YKR098C UBP11 hom Verified 1.68398897669134 0.0460918995603894 no 329 0.0463174971275575 230 NA FT PROTEOLYSIS Ubiquitin-specific protease that cleaves ubiquitin from ubiquitinated proteins biological_process ubiquitin-specific protease activity cellular_component
YDL077C YDL077C VAM6 hom Verified 1.6817893493592 0.0463048473676071 no 330 0.0911799839320474 407 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p regulation of SNARE complex assembly|regulation of vacuole fusion, non-autophagic|piecemeal microautophagy of nucleus|vesicle-mediated transport|vacuole organization|vacuole fusion, non-autophagic Rab guanyl-nucleotide exchange factor activity|phosphatidylinositol binding fungal-type vacuole membrane|HOPS complex|fungal-type vacuole
YDR345C YDR345C HXT3 hom Verified 1.67944973519527 0.046532213620814 no 331 0.0608697769902445 289 NA FT PLASMA MEMBRANE Low affinity glucose transporter of the major facilitator superfamily; expression is induced in low or high glucose conditions; HXT3 has a paralog, HXT5, that arose from the whole genome duplication hexose transport|transmembrane transport mannose transmembrane transporter activity|fructose transmembrane transporter activity|glucose transmembrane transporter activity integral to membrane|plasma membrane
YGL100W YGL100W SEH1 hom Verified 1.67479008954589 0.0469877120143231 no 332 0.0633763508559333 325 NA FF|FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|PLASMA MEMBRANE NUCLEAR PORE Component of two distinct complexes; subunit of the Nup84 nuclear pore sub-complex (NPC) and the Seh1-associated (SEA) complex; the the NUP84 subcomplex contributes to nucleocytoplasmic transport and NPC biogenesis; the SEA complex is a coatamer-related complex that associates dynamically with the vacuole; homologous to human SEH1 nucleocytoplasmic transport structural constituent of nuclear pore fungal-type vacuole membrane|integral to membrane|nuclear pore|Seh1-associated complex|nuclear pore outer ring
YGL158W YGL158W RCK1 hom Verified 1.67458333185348 0.0470080059320143 no 333 0.0316334295108579 166 NA FT CELL CYCLE|PROTEIN PHOSPHORYLATION Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations; RCK1 has a paralog, RCK2, that arose from the whole genome duplication protein phosphorylation|regulation of meiosis protein serine/threonine kinase activity|protein kinase activity cellular_component
YJL180C YJL180C ATP12 hom Verified 1.67443505499832 0.0470225640986695 no 334 0.0521680960615923 274 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Conserved protein required for assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase; mutation of human ATP12 reduces active ATP synthase levels and is associated with the disorder ATPAF2 deficiency mitochondrial proton-transporting ATP synthase complex assembly protein domain specific binding mitochondrion
YDR281C YDR281C PHM6 hom Verified 1.67441133528338 0.0470248932908528 no 335 0.063262771523761 273 NA Protein of unknown function, expression is regulated by phosphate levels biological_process molecular_function fungal-type vacuole
YGR069W_d YGR069W YGR069W hom Dubious 1.67361484678221 0.047103159369991 no 336 0.0596137021790351 266 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR040C_p YLR040C YLR040C hom Uncharacterized 1.6735919352395 0.047105412292224 no 337 0.0517808772348863 250 NA Protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; mRNA identified as translated by ribosome profiling data; YLR040C is not essential biological_process molecular_function fungal-type cell wall
YIL036W YIL036W CST6 hom Verified 1.67274494108606 0.0471887589909729 no 338 0.0344282392321665 239 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS NUCLEUS Basic leucine zipper (bZIP) transcription factor, in ATF/CREB family; mediates transcriptional activation of NCE103 (encoding carbonic anhydrase) in response to low CO2 levels such as in the ambient air; proposed to be a regulator of oleate responsive genes; involved in utilization of non-optimal carbon sources and chromosome stability; CST6 has a paralog, ACA1, that arose from the whole genome duplication cellular response to carbon dioxide|positive regulation of transcription from RNA polymerase II promoter by oleic acid|cellular response to oleic acid|positive regulation of transcription from RNA polymerase II promoter|DNA metabolic process sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YPR124W YPR124W CTR1 hom Verified 1.66941549076197 0.0475175328816812 no 339 0.136486431848958 540 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE High-affinity copper transporter of the plasma membrane; mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels; protein increases in abundance and relocalizes from nucleus to plasma membrane upon DNA replication stress copper ion import copper uptake transmembrane transporter activity integral to membrane|plasma membrane
YMR021C YMR021C MAC1 hom Verified 1.66082396060202 0.0483744037256085 no 340 0.153038659393766 619 NA FF|FT TRANSCRIPTION FROM RNA POL II|ION HOMEOSTASIS|ION HOMEOSTASIS NUCLEUS Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport cellular copper ion homeostasis|positive regulation of protein catabolic process|positive regulation of transcription from RNA polymerase II promoter core promoter proximal region DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YER120W YER120W SCS2 hom Verified 1.65777391547019 0.0486815540643064 no 341 0.0460225011937516 271 NA FT PROTEIN LOCALIZATION|LIPID METABOLISM|GENE SILENCING ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH Integral ER membrane protein, regulates phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PI4P levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; interacts with FFAT motif of Opi1p; involved in telomeric silencing; null shows inositol auxotrophy above 34 deg C; VAP homolog; SCS2 has a paralog, SCS22, that arose from the whole genome duplication endoplasmic reticulum inheritance|regulation of intracellular lipid transport|negative regulation of transcription factor import into nucleus|phospholipid biosynthetic process|chromatin silencing at telomere phosphatidylinositol binding|FFAT motif binding nuclear membrane|integral to endoplasmic reticulum membrane|nuclear envelope|endoplasmic reticulum|cellular bud tip
YER046W-A_d YER046W-A YER046W-A hom Dubious 1.65704426256654 0.0487552632927726 no 342 0.0409491091221061 184 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGL151W YGL151W NUT1 hom Verified 1.65509832438337 0.0489522773678618 no 343 0.0439571380187272 215 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS|MITOCHONDRION Component of the RNA polymerase II mediator complex, which is required for transcriptional activation and also has a role in basal transcription regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter molecular_function mitochondrion|mediator complex|nucleus
YJL004C YJL004C SYS1 hom Verified 1.64982214450404 0.0494896590814856 no 344 0.100332718868645 488 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation vesicle organization|Golgi to plasma membrane protein transport|Golgi to endosome transport molecular_function trans-Golgi network|integral to membrane|integral to Golgi membrane
YOR173W YOR173W DCS2 hom Verified 1.64940151447132 0.0495327023369323 no 345 0.0487638820891698 236 NA Non-essential, stress induced regulatory protein; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway; mutant has increased aneuploidy tolerance deadenylation-dependent decapping of nuclear-transcribed mRNA m7G(5')pppN diphosphatase activity cytoplasmic mRNA processing body|cytoplasm
YDR448W YDR448W ADA2 hom Verified 1.64819686237079 0.0496561402473288 no 346 0.0951322654738216 398 NA FF|FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS HISTONE ACETYLTRANSFERASE Transcription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes chromatin silencing at rDNA|chromatin modification|regulation of transcription from RNA polymerase II promoter|positive regulation of histone acetylation|chromatin silencing at telomere chromatin binding|transcription coactivator activity|histone acetyltransferase activity|phosphatidylserine binding SLIK (SAGA-like) complex|Ada2/Gcn5/Ada3 transcription activator complex|SAGA complex
YGR282C YGR282C BGL2 hom Verified 1.63934516133833 0.0505706977824048 no 347 0.0498707688758882 297 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM Endo-beta-1,3-glucanase, major protein of the cell wall, involved in cell wall maintenance fungal-type cell wall organization 1,3-beta-glucanosyltransferase activity|glucan endo-1,3-beta-D-glucosidase activity fungal-type cell wall
YPR043W YPR043W RPL43A hom Verified 1.63584341312987 0.0509361817493513 no 348 0.0328789518018465 191 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L43A; null mutation confers a dominant lethal phenotype; homologous to mammalian ribosomal protein L37A, no bacterial homolog; RPL43A has a paralog, RPL43B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YFL047W YFL047W RGD2 hom Verified 1.6343738867304 0.0510901839541938 no 349 0.0527617469437643 258 NA FT SIGNALING SITE OF POLARIZED GROWTH GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p; relocalizes from bud neck to cytoplasm upon DNA replication stress small GTPase mediated signal transduction Rho GTPase activator activity cellular bud neck|cytoplasm
YHR067W YHR067W HTD2 hom Verified 1.63334413365366 0.0511983197957695 no 350 0.0778722660908808 366 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION Mitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology fatty acid biosynthetic process 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity mitochondrion
YDL074C YDL074C BRE1 hom Verified 1.62591135717743 0.0519842568740854 no 351 0.107915690171978 409 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING NUCLEUS|CHROMOSOME E3 ubiquitin ligase, forms heterodimer with Rad6p to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR, transcription, silencing, and checkpoint control mitotic cell cycle G1/S transition DNA damage checkpoint|intra-S DNA damage checkpoint|meiotic DNA double-strand break formation|histone monoubiquitination|double-strand break repair via homologous recombination|transcription from RNA polymerase II promoter|chromatin silencing at telomere ubiquitin-protein ligase activity nuclear chromatin
YOR349W YOR349W CIN1 hom Verified 1.62361830926711 0.0522286476833355 no 352 0.0520689314916599 366 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl protein folding|tubulin complex assembly|tubulin complex biogenesis beta-tubulin binding cellular_component
YNL224C YNL224C SQS1 hom Verified 1.62220351146296 0.0523798900453932 no 353 0.0476404727870249 274 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|NUCLEOTIDE METABOLISM NUCLEUS Protein that stimulates the ATPase and helicase activities of Prp43p; acts with Prp43p to stimulate 18s rRNA maturation by Nob1p; overexpression antagonizes the suppression of splicing defects by spp382 mutants; component of pre-ribosomal particles; relocalizes from nucleus to nucleolus upon DNA replication stress positive regulation of helicase activity|positive regulation of ATPase activity|mRNA splicing, via spliceosome|maturation of SSU-rRNA|rRNA processing molecular_function preribosome, small subunit precursor|nucleus|preribosome, large subunit precursor|90S preribosome|cytoplasm
YGR125W_p YGR125W YGR125W hom Uncharacterized 1.61734122777972 0.0529023222908828 no 354 0.0537513266444015 275 NA Putative protein of unknown function; deletion mutant has decreased rapamycin resistance but normal wormannin resistance; green fluorescent protein (GFP)-fusion protein localizes to the vacuole biological_process molecular_function integral to membrane|fungal-type vacuole
YDR296W YDR296W MHR1 hom Verified 1.6141726191243 0.0532449946547631 no 355 0.0733091152681335 305 NA FT MITOCHONDRION ORGANIZATION|RESPONSE TO OXIDATIVE STRESS NUCLEUS|MITOCHONDRION Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress cellular response to oxidative stress|positive regulation of mitochondrial DNA replication|regulation of transcription, DNA-dependent|mitochondrial genome maintenance|DNA recombination single-stranded DNA binding|recombinase activity|DNA binding mitochondrion|nucleus
YKL110C YKL110C KTI12 hom Verified 1.61379235135316 0.0532862370777437 no 356 0.0639931046806861 286 NA FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p regulation of transcription from RNA polymerase II promoter|cell growth|tRNA wobble uridine modification chromatin binding nucleus|cytoplasm
YNL079C YNL079C TPM1 hom Verified 1.60760088715596 0.0539613089035375 no 357 0.0613141578823798 356 NA FF|FT VESICLE-MEDIATED TRANSPORT|CELL DIVISION|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|RNA LOCALIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently; TPM1 has a paralog, TPM2, that arose from the whole genome duplication vacuole inheritance|exocytosis|intracellular mRNA localization|filamentous growth|budding cell apical bud growth|mitochondrion inheritance|budding cell isotropic bud growth|actin polymerization or depolymerization|actin filament organization|pseudohyphal growth|vesicle-mediated transport|establishment of cell polarity|actin filament bundle assembly actin lateral binding cellular bud neck contractile ring|actin filament bundle
YAR014C YAR014C BUD14 hom Verified 1.60350895477896 0.0544111668537442 no 358 0.0498215028138784 304 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH Protein involved in bud-site selection; Bud14p-Glc7p complex is a cortical regulator of dynein; inhibitor of the actin assembly factor Bnr1p (formin); diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; relative distribution to the nucleus increases upon DNA replication stress regulation of cell shape during vegetative growth phase|regulation of protein localization|regulation of transcription, DNA-dependent|cytoskeleton organization|negative regulation of actin filament polymerization protein phosphatase type 1 regulator activity incipient cellular bud site|cellular bud neck|cellular bud tip
YGR237C_p YGR237C YGR237C hom Uncharacterized 1.60285064451784 0.0544838162516075 no 359 0.0505064544478093 258 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm biological_process molecular_function cytoplasm
YPR140W YPR140W TAZ1 hom Verified 1.60241988488486 0.0545313952675035 no 360 0.0510504984707663 182 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|LIPID METABOLISM|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; human ortholog tafazzin is implicated in Barth syndrome cardiolipin acyl-chain remodeling|mitochondrial ATP synthesis coupled electron transport|protein complex assembly|inner mitochondrial membrane organization|cardiolipin metabolic process|phospholipid biosynthetic process 1-acylglycerophosphocholine O-acyltransferase activity mitochondrial outer membrane|mitochondrion|mitochondrial inner membrane|integral to mitochondrial outer membrane
YAL066W_d YAL066W YAL066W hom Dubious 1.59570203662771 0.0552776668599271 no 361 0.0723237747105393 216 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR322W YDR322W MRPL35 hom Verified 1.59536559658688 0.0553152523225234 no 362 0.0725966315117848 301 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YLR439W YLR439W MRPL4 hom Verified 1.59286428322587 0.055595320164074 no 363 0.0869946102956669 339 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit, homolog of prokaryotic L29 ribosomal protein; located at the ribosomal tunnel exit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YHR177W_p YHR177W YHR177W hom Uncharacterized 1.59245343548571 0.0556414289280748 no 364 0.0567330391043167 271 NA Putative protein of unknown function; overexpression causes a cell cycle delay or arrest biological_process molecular_function cellular_component
YMR267W YMR267W PPA2 hom Verified 1.58815859799322 0.0561252402624987 no 365 0.0813460938864848 386 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate aerobic respiration inorganic diphosphatase activity mitochondrion
YGL070C YGL070C RPB9 hom Verified 1.58350362939814 0.0566533600441259 no 366 0.0860069227655887 302 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE NUCLEUS RNA POL II, HOLOENZYME RNA polymerase II subunit B12.6; contacts DNA; mutations affect transcription start site selection and fidelity of transcription transcription initiation from RNA polymerase II promoter|maintenance of transcriptional fidelity during DNA-dependent transcription elongation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|response to DNA damage stimulus|transcription from RNA polymerase II promoter RNA-directed RNA polymerase activity DNA-directed RNA polymerase II, core complex
YGR037C YGR037C ACB1 hom Verified 1.58219308105063 0.0568027496998049 no 367 0.131742134576255 547 NA FF|FT KETONE METABOLISM|LIPID METABOLISM NUCLEUS Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion; protein abundance increases in response to DNA replication stress long-chain fatty acid transport|chronological cell aging|fatty acid metabolic process long-chain fatty acid transporter activity|fatty-acyl-CoA binding extracellular region|nucleus|cytoplasm
YHR043C YHR043C DOG2 hom Verified 1.57959198952582 0.0571001674564489 no 368 0.0614956853228784 243 NA FT CARBOHYDRATE METABOLISM NUCLEUS 2-deoxyglucose-6-phosphate phosphatase; member of a family of low molecular weight phosphatases, paralogous to DOG1, induced by oxidative and osmotic stress, confers 2-deoxyglucose resistance when overexpressed glucose metabolic process 2-deoxyglucose-6-phosphatase activity nucleus|cytoplasm
YOL048C YOL048C RRT8 hom Verified 1.57649106533705 0.0574563381186404 no 369 0.0535922482514407 222 NA Protein of unknown function; identified in a screen for mutants with increased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to lipid particles; protein abundance increases in response to DNA replication stress biological_process molecular_function integral to membrane|lipid particle
YEL059C-A YEL059C-A SOM1 hom Verified 1.5729870635613 0.0578609068432131 no 370 0.0477712903169389 222 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs proteolysis|mitochondrial respiratory chain complex assembly endopeptidase activity mitochondrial inner membrane peptidase complex|mitochondrial inner membrane
YCR067C YCR067C SED4 hom Verified 1.57290857292356 0.0578699948753749 no 371 0.0565681709998618 249 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|NUCLEOTIDE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Integral endoplasmic reticulum membrane protein that stimulates Sar1p GTPase activity; involved in COPII vesicle budding through disassociation of coat proteins from membranes onto liposomes; binds Sec16p; similar to Sec12p positive regulation of GTPase activity|regulation of COPII vesicle coating Sar GTPase activator activity integral to endoplasmic reticulum membrane
YCR101C_p YCR101C YCR101C hom Uncharacterized 1.57219387235064 0.0579527980581595 no 372 0.0587100774208684 321 NA Putative protein of unknown function; localizes to the membrane fraction; YCR101C is not an essential gene biological_process molecular_function integral to membrane|membrane
YOR121C_d YOR121C YOR121C hom Dubious 1.56825512846541 0.0584108016671303 no 373 0.0530312161316839 263 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GCY1/YOR120W Unknown Unknown Unknown
YER163C YER163C GCG1 hom Verified 1.56803522892761 0.0584364554903705 no 374 0.0559150695612436 308 NA FT NUCLEUS Gamma-glutamyl cyclotransferase; cleaves the gamma-glutamyl bond of glutathione to yield 5-oxoproline and a Cys-Gly dipeptide; similar to mammalian pro-apoptotic protein ChaC1; expression of mouse ChaC1 in yeast increases apoptosis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; periodically expressed during the metabolic cycle biological_process molecular_function nucleus|cytoplasm
YGL188C-A_p YGL188C-A YGL188C-A hom Uncharacterized 1.56538567940774 0.0587462520989202 no 375 0.0783889176915879 375 NA Putative protein of unknown function biological_process molecular_function cellular_component
YCR025C_d YCR025C YCR025C hom Dubious 1.56365215480039 0.0589496397740005 no 376 0.0647623381580352 325 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR025C is not an essential gene Unknown Unknown Unknown
YOR096W YOR096W RPS7A hom Verified 1.5628346967354 0.0590457404266872 no 377 0.0858306832157342 328 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION NUCLEUS RIBOSOME Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7A has a paralog, RPS7B, that arose from the whole genome duplication cytoplasmic translation|ribosome biogenesis structural constituent of ribosome small-subunit processome|cytosolic small ribosomal subunit|90S preribosome
YMR246W YMR246W FAA4 hom Verified 1.55891058547684 0.0595087722854369 no 378 0.0556684806974578 277 NA FT KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM Long chain fatty acyl-CoA synthetase; activates imported fatty acids with a preference for C12:0-C16:0 chain lengths; functions in long chain fatty acid import; important for survival during stationary phase; localized to lipid particles; involved in sphingolipid-to-glycerolipid metabolism; forms cytoplasmic foci upon DNA replication stress; FAA4 has a paralog, FAA1, that arose from the whole genome duplication long-chain fatty acid transport|long-chain fatty-acyl-CoA metabolic process long-chain fatty acid-CoA ligase activity lipid particle|cytoplasm
YML036W YML036W CGI121 hom Verified 1.55846789242253 0.0595611867218203 no 379 0.076736931074711 302 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS|CHROMOSOME Component of the EKC/KEOPS complex with Bud32p, Kae1p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription; Cgi121p is dispensable for tRNA modification telomere maintenance|positive regulation of transcription from RNA polymerase II promoter molecular_function EKC/KEOPS complex
YLR426W_p YLR426W TDA5 hom Uncharacterized 1.5584370150387 0.0595648439240712 no 380 0.101142306536513 414 NA FT OXIDATION-REDUCTION PROCESS MITOCHONDRION Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele response to drug molecular_function mitochondrion|integral to membrane
YFL013W-A_d YFL013W-A YFL013W-A hom Dubious 1.5565583127931 0.0597876938824208 no 381 0.0720575444917266 313 NA Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps IES1/YFL013C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching Unknown Unknown Unknown
YFR010W YFR010W UBP6 hom Verified 1.5529759847102 0.0602144360260571 no 382 0.10169496170376 395 NA FT PROTEOLYSIS Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains; works in opposition to Hul5p polyubiquitin elongation activity; mutant has aneuploidy tolerance protein deubiquitination ubiquitin-specific protease activity proteasome complex|proteasome regulatory particle
YLR052W YLR052W IES3 hom Verified 1.55082903886412 0.060471329784651 no 383 0.0680860653850723 324 NA FT CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Subunit of the INO80 chromatin remodeling complex nucleosome mobilization|telomere maintenance|chromatin silencing at telomere molecular_function nucleus|Ino80 complex
YDR442W_d YDR442W YDR442W hom Dubious 1.54637487679869 0.0610070290033035 no 384 0.0882779655852589 341 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YER017C YER017C AFG3 hom Verified 1.54563033988507 0.0610969347532742 no 385 0.0968727221338779 377 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Component, with Yta12p, of the mitochondrial inner membrane m-AAA protease; mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes; involved in cytoplasmic mRNA translation and aging proteolysis|signal peptide processing|protein complex assembly|protein import into mitochondrial intermembrane space metallopeptidase activity|protein binding|ATPase activity mitochondrion|mitochondrial inner boundary membrane|mitochondrial inner membrane|m-AAA complex
YHR163W YHR163W SOL3 hom Verified 1.54366313921283 0.0613349802332853 no 386 0.0571179107232188 301 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS NUCLEUS 6-phosphogluconolactonase; catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p; SOL3 has a paralog, SOL4, that arose from the whole genome duplication pentose-phosphate shunt, oxidative branch 6-phosphogluconolactonase activity nucleus|cytoplasm
YPL053C YPL053C KTR6 hom Verified 1.54122844990847 0.0616305978324742 no 387 0.0594101751594134 278 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM Probable mannosylphosphate transferase; involved in the synthesis of core oligosaccharides in protein glycosylation pathway; member of the KRE2/MNT1 mannosyltransferase family; KTR6 has a paralog, KRE2, that arose from the whole genome duplication fungal-type cell wall organization|protein N-linked glycosylation mannosylphosphate transferase activity membrane
YMR082C_d YMR082C YMR082C hom Dubious 1.5375503795873 0.0620792939580362 no 388 0.0746916001352608 255 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPL037C YPL037C EGD1 hom Verified 1.53595640966702 0.062274535818791 no 389 0.073391814161814 317 NA FT PROTEIN LOCALIZATION NUCLEUS Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b 'de novo' cotranslational protein folding unfolded protein binding nascent polypeptide-associated complex
YML037C_p YML037C YML037C hom Uncharacterized 1.53424596073879 0.0624845772817565 no 390 0.0879949856350808 327 NA Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene biological_process molecular_function clathrin-coated vesicle
YKR105C_p YKR105C VBA5 hom Uncharacterized 1.53093795036681 0.0628923643808468 no 391 0.0610174793116208 284 NA Plasma membrane protein of the Major Facilitator Superfamily (MFS); involved in amino acid uptake and drug sensitivity; similar to Vba3p biological_process molecular_function integral to membrane
YHR200W YHR200W RPN10 hom Verified 1.53079775869459 0.0629096918637378 no 392 0.0628933767613264 329 NA FT PROTEOLYSIS Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein ubiquitin-dependent protein catabolic process structural molecule activity|polyubiquitin binding proteasome complex|proteasome regulatory particle, base subcomplex
YLR085C YLR085C ARP6 hom Verified 1.52883606346396 0.0631525448056877 no 393 0.1010838230278 482 NA FF|FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A chromatin remodeling|histone exchange nucleosome binding Swr1 complex|cytoplasm
YLR260W YLR260W LCB5 hom Verified 1.52672762067249 0.063414378088459 no 394 0.0939906867568057 359 NA FT LIPID METABOLISM|SIGNALING|PROTEIN PHOSPHORYLATION ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules response to heat|calcium-mediated signaling|sphingolipid metabolic process D-erythro-sphingosine kinase activity Golgi apparatus|membrane
YJR135C YJR135C MCM22 hom Verified 1.52199006931169 0.0640057845014928 no 395 0.0492914270377878 217 NA FT CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME KINETOCHORE Outer kinetochore protein and component of the Ctf3 subcomplex; binds to centromeric DNA in a Ctf19p-dependent manner; involved in chromosome segregation and minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-K and fission yeast sim4 chromosome segregation|establishment of mitotic sister chromatid cohesion molecular_function condensed nuclear chromosome kinetochore
YCR007C_p YCR007C YCR007C hom Uncharacterized 1.5174983149733 0.0645704593005983 no 396 0.077939206279368 290 NA Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene biological_process molecular_function cellular_component
YMR171C YMR171C EAR1 hom Verified 1.51642640505936 0.0647057832366981 no 397 0.0610413107376118 281 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT Specificity factor required for Rsp5p-dependent ubiquitination and sorting of specific cargo proteins at the multivesicular body; mRNA is targeted to the bud via the mRNA transport system involving She2p protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway molecular_function endosome
YOL150C_d YOL150C YOL150C hom Dubious 1.5135951360719 0.0650642777579669 no 398 0.0552809191614843 208 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YNL305C YNL305C BXI1 hom Verified 1.51313003243703 0.0651233161871612 no 399 0.0562163992710042 211 NA FT SIGNALING ENDOPLASMIC RETICULUM|MITOCHONDRION Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p endoplasmic reticulum unfolded protein response|apoptotic process|calcium-mediated signaling molecular_function mitochondrion|integral to membrane|endoplasmic reticulum|fungal-type vacuole
YDR375C YDR375C BCS1 hom Verified 1.51217481053864 0.0652446986620117 no 400 0.0784752636285659 312 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases protein insertion into mitochondrial membrane from inner side|chaperone-mediated protein complex assembly|mitochondrial respiratory chain complex III assembly protein transmembrane transporter activity|ATPase activity mitochondrion|mitochondrial inner membrane
YPR118W YPR118W MRI1 hom Verified 1.51215299998867 0.0652474722323607 no 401 0.0749641235936363 244 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS 5'-methylthioribose-1-phosphate isomerase; catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway L-methionine salvage from methylthioadenosine S-methyl-5-thioribose-1-phosphate isomerase activity nucleus|cytoplasm
YOR296W_p YOR296W YOR296W hom Uncharacterized 1.50788855651599 0.0657915259707499 no 402 0.0361041388194712 160 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; expressed during copper starvation; YOR296W is not an essential gene biological_process molecular_function cytoplasm
YLR414C YLR414C PUN1 hom Verified 1.50633664825843 0.0659903873475205 no 403 0.0429628351039217 192 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL WALL ORG/BIOGENESIS PLASMA MEMBRANE Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress fungal-type cell wall organization|protein oligomerization molecular_function integral to membrane|membrane raft|plasma membrane|cellular bud|cytoplasm
YFR036W YFR036W CDC26 hom Verified 1.50633386071955 0.0659907449610513 no 404 0.100340803226804 473 NA FF|FT CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION|PROTEOLYSIS NUCLEUS UBIQUITIN LIGASE COMPLEX Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition chromatin assembly|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination ubiquitin-protein ligase activity anaphase-promoting complex
YNL076W YNL076W MKS1 hom Verified 1.50366900094949 0.0663333073860299 no 405 0.055722188624611 239 NA FT TRANSCRIPTION FROM RNA POL II|SIGNALING NUCLEUS Pleiotropic negative transcriptional regulator involved in Ras-CAMP and lysine biosynthetic pathways and nitrogen regulation; involved in retrograde (RTG) mitochondria-to-nucleus signaling regulation of nitrogen utilization|negative regulation of transcription from RNA polymerase II promoter|Unknown|mitochondria-nucleus signaling pathway molecular_function cytoplasm
YGR137W_d YGR137W YGR137W hom Dubious 1.50366335565477 0.0663340345363056 no 406 0.0597779516008774 252 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPL161C YPL161C BEM4 hom Verified 1.4997065976241 0.0668452104019654 no 407 0.144330477814175 520 NA FF|FT SIGNALING|CYTOSKELETON ORGANIZATION NUCLEUS Protein involved in establishment of cell polarity and bud emergence; interacts with the Rho1p small GTP-binding protein and with the Rho-type GTPase Cdc42p; involved in maintenance of proper telomere length establishment of cell polarity|Rho protein signal transduction|actin cytoskeleton organization molecular_function nucleus|cytoplasm
YDR384C YDR384C ATO3 hom Verified 1.49957352931308 0.06686245439617 no 408 0.0597102281339256 247 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION|PLASMA MEMBRANE Plasma membrane protein, regulation pattern suggests a possible role in export of ammonia from the cell; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family of putative transporters ammonium transport|nitrogen utilization|transmembrane transport ammonium transmembrane transporter activity mitochondrion|integral to membrane|plasma membrane
YPR030W YPR030W CSR2 hom Verified 1.49846482789147 0.0670062620976548 no 409 0.0780450602913914 287 NA FT VESICLE-MEDIATED TRANSPORT|TRANSCRIPTION FROM RNA POL II|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS NUCLEUS Nuclear ubiquitin protein ligase binding protein; may regulate utilization of nonfermentable carbon sources and endocytosis of plasma membrane proteins; overproduction suppresses chs5 spa2 lethality at high temp; ubiquitinated by Rsp5p, deubiquitinated by Ubp2p; CSR2 has a paralog, ECM21, that arose from the whole genome duplication fungal-type cell wall organization|regulation of transcription from RNA polymerase II promoter|ubiquitin-dependent endocytosis ubiquitin protein ligase binding nucleus
YOR213C YOR213C SAS5 hom Verified 1.49491536586078 0.0674682657631673 no 410 0.0816806656510876 393 NA FT CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME HISTONE ACETYLTRANSFERASE Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity chromatin silencing at telomere acetyltransferase activity|histone acetyltransferase activity nuclear chromatin|SAS acetyltransferase complex|nuclear chromosome, telomeric region
YPL023C YPL023C MET12 hom Verified 1.49406229771475 0.0675796685678847 no 411 0.072389223044045 313 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS Protein with methylenetetrahydrofolate reductase (MTHFR) activity in vitro; null mutant has no phenotype and is prototrophic for methionine; MET13 encodes major isozyme of MTHFR biological_process methylenetetrahydrofolate reductase (NADPH) activity cellular_component
YBR159W YBR159W IFA38 hom Verified 1.49385771209681 0.0676064066749371 no 412 0.0676018756167694 295 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Microsomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides fatty acid elongation ketoreductase activity integral to membrane|endoplasmic reticulum
YKR059W YKR059W TIF1 hom Verified 1.49178808565849 0.0678773541512465 no 413 0.0664171237146446 262 NA FT TRANSLATION RIBOSOME Translation initiation factor eIF4A; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; protein abundance increases in response to DNA replication stress; TIF1 has a paralog, TIF2, that arose from the whole genome duplication translational initiation ATP-dependent RNA helicase activity|translation initiation factor activity ribosome|eukaryotic translation initiation factor 4F complex
YGR014W YGR014W MSB2 hom Verified 1.49154948482507 0.0679086446841892 no 414 0.0996995661966138 356 NA FT SIGNALING SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Mucin family member involved in signaling; functions in the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; is processed into secreted and cell-associated forms by the aspartyl protease, Yps1p; also functions as an osmosensor in parallel to the Sho1p-mediated pathway; potential Cdc28p substrate signal transduction involved in filamentous growth|osmosensory signaling pathway via Sho1 osmosensor|establishment of cell polarity|hyperosmotic response|response to osmotic stress osmosensor activity site of polarized growth|integral to plasma membrane
YDR233C YDR233C RTN1 hom Verified 1.48604600275817 0.0686334766923058 no 415 0.051845241019833 240 NA FT PROTEIN COMPLEX ORG/BIOGENESIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS Reticulon protein; stabilizes membrane curvature; involved in nuclear pore assembly and maintenance of tubular ER morphology; mutant overexpressing RTN1 shows increase in tubular ER; interacts with exocyst subunit Sec6p, Yip3p, and Sbh1p; more abundant than Rtn2p; member of the RTNLA subfamily; mutants have reduced phosphatidylserine transfer between the ER and mitochondria; RTN1 has a paralog, RTN2, that arose from the whole genome duplication endoplasmic reticulum tubular network organization|endoplasmic reticulum organization|endoplasmic reticulum tubular network maintenance|nuclear pore complex assembly molecular_function integral to endoplasmic reticulum membrane|mitochondrion|Golgi apparatus|endoplasmic reticulum|cortical endoplasmic reticulum|endoplasmic reticulum tubular network
YBR025C YBR025C OLA1 hom Verified 1.48493282816618 0.0687808093978611 no 416 0.0706659005139492 327 NA P-loop ATPase with similarity to human OLA1 and bacterial YchF; identified as specifically interacting with the proteasome; protein abundance increases in response to hydrogen peroxide and to DNA replication stress biological_process ATPase activity cytoplasm
YHR031C YHR031C RRM3 hom Verified 1.48097089302002 0.0693071649814776 no 417 0.0867749098776476 342 NA FT RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION NUCLEUS|CHROMOSOME DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p mitochondrial genome maintenance|replication fork progression beyond termination site|DNA replication ATP-dependent DNA helicase activity|DNA helicase activity nuclear telomeric heterochromatin|replication fork
YCR045C YCR045C RRT12 hom Verified 1.47984760671441 0.0694569602709666 no 418 0.073987695510163 353 NA FT CELL WALL ORG/BIOGENESIS|PROTEOLYSIS ENDOMEMBRANE SYSTEM|NUCLEUS Probable subtilisin-family protease with a role in formation of the dityrosine layer of spore walls; localizes to the spore wall and also the nuclear envelope and ER region in mature spores ascospore wall assembly serine-type peptidase activity nuclear envelope|ascospore wall
YML124C YML124C TUB3 hom Verified 1.47759734633832 0.0697577925350005 no 419 0.140684793176433 556 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|NUCLEOTIDE METABOLISM|CHROMOSOME SEGREGATION NUCLEUS|CYTOSKELETON Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication nuclear migration along microtubule|nuclear migration involved in conjugation with cellular fusion|homologous chromosome segregation|mitotic sister chromatid segregation structural constituent of cytoskeleton tubulin complex|cytoplasmic microtubule|kinetochore microtubule|nuclear microtubule|spindle pole body|polar microtubule
YOL083W YOL083W ATG34 hom Verified 1.4769888662341 0.0698393108924418 no 420 0.0523587366792233 197 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS Receptor protein involved in selective autophagy during starvation; specifically involved in the transport of cargo protein alpha-mannosidase (Ams1p); Atg19p paralog protein complex assembly|protein complex localization protein binding, bridging CVT complex
YMR265C_p YMR265C YMR265C hom Uncharacterized 1.47668922413891 0.0698794810124116 no 421 0.0689102757688978 315 NA Putative protein of unknown function biological_process molecular_function cellular_component
YOR155C YOR155C ISN1 hom Verified 1.47638006166168 0.0699209460726496 no 422 0.0660709734542829 220 NA FT NUCLEOTIDE METABOLISM Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms nicotinamide riboside biosynthetic process|inosine salvage|nicotinic acid riboside biosynthetic process IMP 5'-nucleotidase activity cellular_component
YJR037W_d YJR037W YJR037W hom Dubious 1.47599878304173 0.0699721094639396 no 423 0.0548997217193335 214 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene HUL4/YJR036C; deletion mutant has decreased spore survival in Drosophila feces Unknown Unknown Unknown
YPL215W YPL215W CBP3 hom Verified 1.47476006394512 0.0701385307528702 no 424 0.0513068395480106 232 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex positive regulation of mitochondrial translation|mitochondrial respiratory chain complex III assembly ribosome binding integral to mitochondrial membrane|mitochondrion|mitochondrial ribosome
YLR177W_p YLR177W YLR177W hom Uncharacterized 1.4745692701771 0.0701641908366597 no 425 0.0662761263595862 229 NA Putative protein of unknown function; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; not an essential gene; YLR177W has a paralog, PSP1, that arose from the whole genome duplication biological_process molecular_function cytoplasm
YOR209C YOR209C NPT1 hom Verified 1.47337756630826 0.070324627958555 no 426 0.115296299696054 459 NA FF|FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|GENE SILENCING|RESPONSE TO OXIDATIVE STRESS NUCLEUS Nicotinate phosphoribosyltransferase, acts in the salvage pathway of NAD+ biosynthesis; required for silencing at rDNA and telomeres and has a role in silencing at mating-type loci; localized to the nucleus chromatin silencing at rDNA|replicative cell aging|nicotinate nucleotide salvage|chromatin silencing at telomere nicotinate phosphoribosyltransferase activity nucleus
YGL105W YGL105W ARC1 hom Verified 1.47038297204593 0.0707290302562755 no 427 0.0818126813560917 329 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p), delivering tRNA to them, stimulating catalysis, and ensuring their localization to the cytoplasm; also binds quadruplex nucleic acids; protein abundance increases in response to DNA replication stress positive regulation of ligase activity|tRNA aminoacylation for protein translation enzyme activator activity|tRNA binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding methionyl glutamyl tRNA synthetase complex|cytoplasm
YNL195C_p YNL195C YNL195C hom Uncharacterized 1.46671148200681 0.0712272790316737 no 428 0.0876535605953804 377 NA FT MITOCHONDRION Putative protein of unknown function; shares a promoter with YNL194C; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YMR250W YMR250W GAD1 hom Verified 1.46120925163192 0.0719790124338885 no 429 0.0776256575917005 352 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|RESPONSE TO OXIDATIVE STRESS Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress cellular response to oxidative stress|glutamate catabolic process calmodulin binding|glutamate decarboxylase activity cytoplasm
YNR041C YNR041C COQ2 hom Verified 1.46045034144432 0.0720831729451902 no 430 0.0705931785944432 289 NA FT KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM MITOCHONDRION Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis ubiquinone biosynthetic process 4-hydroxybenzoate octaprenyltransferase activity mitochondrion|integral to mitochondrial membrane|integral to membrane
YLR338W_d YLR338W OPI9 hom Dubious 1.46004183976199 0.072139287666201 no 431 0.127415218462659 513 NA FF Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF VRP1/YLR337C Unknown Unknown Unknown
YMR062C YMR062C ARG7 hom Verified 1.45899123867216 0.072283759562666 no 432 0.100258835086291 413 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS MITOCHONDRION Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine fungal-type cell wall organization|ornithine biosynthetic process|arginine biosynthetic process acetyl-CoA:L-glutamate N-acetyltransferase activity|glutamate N-acetyltransferase activity mitochondrion|mitochondrial matrix
YIR044C YIR044C YIR044C hom pseudogene 1.45809699127498 0.0724069052992441 no 433 0.0768500644293077 317 NA Possible pseudogene in strain S288C; YIR044C and the adjacent ORF, YIR043C, together may encode a non-functional member of the conserved, often subtelomerically-encoded Cos protein family biological_process molecular_function cellular_component
YGR067C_p YGR067C YGR067C hom Uncharacterized 1.45801578708303 0.0724180957871231 no 434 0.057916464093904 244 NA FT NUCLEUS Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p biological_process sequence-specific DNA binding cellular_component
YLR418C YLR418C CDC73 hom Verified 1.45046598135167 0.0734643095131663 no 435 0.159926416430041 592 NA FF|FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION NUCLEUS|CHROMOSOME RNA POL II, HOLOENZYME Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; protein abundance increases in response to DNA replication stress transcription elongation from RNA polymerase I promoter|negative regulation of DNA recombination|mRNA 3'-end processing|recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex|positive regulation of transcription elongation from RNA polymerase II promoter|Unknown|regulation of transcription-coupled nucleotide-excision repair|transcription elongation from RNA polymerase II promoter chromatin binding|TFIIF-class binding transcription factor activity|RNA polymerase II core binding|RNA polymerase II transcription factor binding transcription factor activity nucleus|transcriptionally active chromatin|Cdc73/Paf1 complex
YDR519W YDR519W FPR2 hom Verified 1.44715658966839 0.0739265357992171 no 436 0.0989874794320126 377 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase); binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking; relocalizes from nucleus to vacuole upon DNA replication stress biological_process FK506 binding|peptidyl-prolyl cis-trans isomerase activity endoplasmic reticulum membrane
YGL071W YGL071W AFT1 hom Verified 1.44638848971454 0.0740341342205271 no 437 0.18914894534547 686 NA FF|FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|ION HOMEOSTASIS|ION HOMEOSTASIS|RESPONSE TO NUTRIENT LEVELS|CHROMOSOME SEGREGATION NUCLEUS Transcription factor involved in iron utilization and homeostasis; binds consensus site PyPuCACCCPu and activates transcription in response to changes in iron availability; in iron-replete conditions activity is negatively regulated by Grx3p, Grx4p, and Fra2p, which regulate Aft1p translocation from the nucleus to the cytoplasm; AFT1 has a paralog, AFT2, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress positive regulation of transcription from RNA polymerase II promoter in response to iron ion starvation|meiotic chromosome segregation|positive regulation of iron ion transport|establishment of mitotic sister chromatid cohesion|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding nucleus|cytoplasm
YGL257C YGL257C MNT2 hom Verified 1.44563944903121 0.0741391779349544 no 438 0.072216036284729 250 NA FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans protein O-linked glycosylation alpha-1,3-mannosyltransferase activity cellular_component
YLR273C YLR273C PIG1 hom Verified 1.43919698123936 0.0750473602310089 no 439 0.04768266166236 249 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Putative targeting subunit for the type-1 protein phosphatase Glc7p that tethers it to the Gsy2p glycogen synthase regulation of glycogen biosynthetic process protein phosphatase type 1 regulator activity protein phosphatase type 1 complex
YDR264C YDR264C AKR1 hom Verified 1.43746052872381 0.075293590296453 no 440 0.160889021663966 595 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats; AKR1 has a paralog, AKR2, that arose from the whole genome duplication protein targeting to membrane|regulation of endocytosis|regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion|protein palmitoylation palmitoyltransferase activity integral to membrane|Golgi apparatus|membrane
YDR042C_p YDR042C YDR042C hom Uncharacterized 1.43499287367421 0.0756445641656163 no 441 0.0525587212320699 205 NA Putative protein of unknown function; expression is increased in ssu72-ts69 mutant biological_process molecular_function cellular_component
YPL104W YPL104W MSD1 hom Verified 1.42816277643151 0.0766225059685433 no 442 0.102450892138209 407 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial aspartyl-tRNA synthetase, required for acylation of aspartyl-tRNA; yeast and bacterial aspartyl-, asparaginyl-, and lysyl-tRNA synthetases contain regions with high sequence similarity, suggesting a common ancestral gene mitochondrial aspartyl-tRNA aminoacylation aspartate-tRNA ligase activity mitochondrion
YNR057C YNR057C BIO4 hom Verified 1.42662326608041 0.0768442571261949 no 443 0.0907941556366674 369 NA FT KETONE METABOLISM|COFACTOR METABOLISM Dethiobiotin synthetase, catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; expression appears to be repressed at low iron levels biotin biosynthetic process dethiobiotin synthase activity cytoplasm
YPR050C_d YPR050C YPR050C hom Dubious 1.42644004128475 0.0768706812924351 no 444 0.110619466639896 428 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MAK3/YPR051W Unknown Unknown Unknown
YMR038C YMR038C CCS1 hom Verified 1.42538437305199 0.0770230613753045 no 445 0.146106985251436 565 NA FF|FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS NUCLEUS|MITOCHONDRION Copper chaperone for superoxide dismutase Sod1p; involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation; protein abundance increases in response to DNA replication stress intracellular copper ion transport superoxide dismutase copper chaperone activity cytosol|mitochondrial inner membrane|nucleus
YLL018C-A YLL018C-A COX19 hom Verified 1.42465391130929 0.0771286339438913 no 446 0.0929926213000848 341 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS MITOCHONDRION Protein required for cytochrome c oxidase assembly, located in the cytosol and mitochondrial intermembrane space; putative copper metallochaperone that delivers copper to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs mitochondrial respiratory chain complex IV assembly|metal ion transport copper ion binding|copper chaperone activity cytosol|mitochondrial intermembrane space
YIL079C YIL079C AIR1 hom Verified 1.42324262874478 0.077332915946371 no 447 0.0820319904310146 318 NA FT RNA PROCESSING NUCLEUS Zinc knuckle protein; involved in nuclear RNA processing and degradation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; AIR1 has a paralog, AIR2, that arose from the whole genome duplication nuclear mRNA surveillance of mRNA 3'-end processing|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|ncRNA polyadenylation|nuclear polyadenylation-dependent snRNA catabolic process polynucleotide adenylyltransferase activity nucleolus|TRAMP complex
YHR013C YHR013C ARD1 hom Verified 1.419043491215 0.0779431684736187 no 448 0.0770577330766575 382 NA FT CHROMATIN ORGANIZATION RIBOSOME Subunit of protein N-terminal acetyltransferase NatA; NatA is comprised of Nat1p, Ard1p, and Nat5p; acetylates many proteins and thus affects telomeric silencing, cell cycle, heat-shock resistance, mating, and sporulation; human Ard1p levels are elevated in cancer cells; protein abundance increases in response to DNA replication stress histone acetylation|N-terminal protein amino acid acetylation peptide alpha-N-acetyltransferase activity cytosolic ribosome|NatA complex
YLR192C YLR192C HCR1 hom Verified 1.41842907108639 0.0780327665730177 no 449 0.115744210197267 452 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION Dual function protein involved in translation initiation as a substoichiometric component (eIF3j) of translation initiation factor 3 (eIF3) and required for processing of 20S pre-rRNA; binds to eIF3 subunits Rpg1p and Prt1p and 18S rRNA cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) translation initiation factor activity eukaryotic translation initiation factor 3 complex
YDR440W YDR440W DOT1 hom Verified 1.41489679609823 0.0785493787601769 no 450 0.0801407657998751 304 NA FT CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING NUCLEUS Nucleosomal histone H3-Lys79 methylase; methylation is required for telomeric silencing, meiotic checkpoint control, and DNA damage response meiotic recombination checkpoint|postreplication repair|recombinational repair|global genome nucleotide-excision repair|nucleotide-excision repair|DNA damage checkpoint|chromatin silencing at telomere|histone H3-K79 methylation nucleosomal histone binding|histone methyltransferase activity (H3-K79 specific) nucleus
YGR008C YGR008C STF2 hom Verified 1.41273828154387 0.0788663456126121 no 451 0.0767609030761068 259 NA FT MITOCHONDRION Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress cellular response to desiccation molecular_function cytoplasm
YCR079W YCR079W PTC6 hom Verified 1.41055246517439 0.0791883080860337 no 452 0.0928001688285619 412 NA FT RESPONSE TO NUTRIENT LEVELS MITOCHONDRION Mitochondrial type 2C protein phosphatase (PP2C) with similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase mitochondrion degradation|positive regulation of catalytic activity|macroautophagy|protein dephosphorylation protein serine/threonine phosphatase activity mitochondrion|mitochondrial matrix|mitochondrial intermembrane space
YBR189W YBR189W RPS9B hom Verified 1.41019003483044 0.0792417887539911 no 453 0.0837884238542421 312 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION NUCLEUS RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog, RPS9A, that arose from the whole genome duplication positive regulation of translational fidelity|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome small-subunit processome|cytosolic small ribosomal subunit|90S preribosome
YBL013W YBL013W FMT1 hom Verified 1.40980302367746 0.0792989267816435 no 454 0.0999454965250361 333 NA FT KETONE METABOLISM|RNA PROCESSING|AMINO ACID METABOLISM|TRANSLATION MITOCHONDRION Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate translational initiation|methionyl-tRNA aminoacylation methionyl-tRNA formyltransferase activity mitochondrion
YBL057C YBL057C PTH2 hom Verified 1.40867325321976 0.0794659036366599 no 455 0.0926032234807933 374 NA FT PROTEOLYSIS MITOCHONDRION One of two (see also PTH1) mitochondrially-localized peptidyl-tRNA hydrolases; negatively regulates the ubiquitin-proteasome pathway via interactions with ubiquitin-like ubiquitin-associated proteins; dispensable for cell growth negative regulation of proteasomal ubiquitin-dependent protein catabolic process aminoacyl-tRNA hydrolase activity mitochondrial outer membrane|mitochondrion|cytoplasm
YDR483W YDR483W KRE2 hom Verified 1.40126124267977 0.0805679832391959 no 456 0.121928680816145 410 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Alpha1,2-mannosyltransferase of the Golgi; involved in protein mannosylation; KRE2 has a paralog, KTR6, that arose from the whole genome duplication N-glycan processing|cell wall mannoprotein biosynthetic process|protein O-linked glycosylation alpha-1,2-mannosyltransferase activity Golgi apparatus
YGR247W YGR247W CPD1 hom Verified 1.40006783135113 0.0807465034997048 no 457 0.0738196261389166 317 NA FT NUCLEOTIDE METABOLISM GOLGI APPARATUS Cyclic nucleotide phosphodiesterase; hydrolyzes ADP-ribose 1'', 2''-cyclic phosphate to ADP-ribose 1''-phosphate; may have a role in tRNA splicing; no detectable phenotype is conferred by null mutation or by overexpression; protein abundance increases in response to DNA replication stress cyclic nucleotide metabolic process 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity clathrin-coated vesicle
YIL001W_p YIL001W YIL001W hom Uncharacterized 1.39505144145149 0.0815001638540048 no 458 0.0961768119798678 328 NA Putative protein of unknown function; contains a BTB/POZ domain which generally function in protein interactions; deletion slightly improved competitive fitness in rich media; GFP-tagged protein is localized to the cytoplasm biological_process molecular_function cytoplasm
YDL243C YDL243C AAD4 hom Verified 1.39456925403865 0.0815728860308964 no 459 0.0725009810342565 293 NA FT OXIDATION-REDUCTION PROCESS Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin cellular aldehyde metabolic process aryl-alcohol dehydrogenase (NAD+) activity cellular_component
YJR113C YJR113C RSM7 hom Verified 1.39146928951455 0.0820415830027522 no 460 0.10911509632756 435 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S7 ribosomal protein mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YKL007W YKL007W CAP1 hom Verified 1.39102493774727 0.0821089323847137 no 461 0.0845451277641891 371 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Alpha subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress barbed-end actin filament capping actin filament binding actin filament|F-actin capping protein complex|mating projection tip|actin cortical patch
YDL130W YDL130W RPP1B hom Verified 1.39088899865728 0.0821295446796942 no 462 0.0979140879286169 362 NA FT TRANSLATION RIBOSOME Ribosomal protein P1 beta, component of the ribosomal stalk, which is involved in interaction of translational elongation factors with ribosome; accumulation is regulated by phosphorylation and interaction with the P2 stalk component cytoplasmic translation|translational elongation structural constituent of ribosome cytosolic large ribosomal subunit
YMR125W YMR125W STO1 hom Verified 1.39079065770554 0.0821444584399428 no 463 0.101539337326398 392 NA FT RNA PROCESSING|RNA LOCALIZATION NUCLEUS Large subunit of the nuclear mRNA cap-binding protein complex, interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|mRNA splicing, via spliceosome|response to osmotic stress mRNA binding commitment complex|nuclear cap binding complex|polysome
YHR076W YHR076W PTC7 hom Verified 1.38999178644573 0.0822656857553065 no 464 0.0991249537373827 396 NA FT ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION Type 2C protein phosphatase (PP2C); alternatively spliced to create two mRNA isoforms; protein from spliced form localizes to the mitochondria while the one from the unspliced form is localized to the nuclear envelope biological_process protein serine/threonine phosphatase activity nuclear envelope|mitochondrion
YCL005W YCL005W LDB16 hom Verified 1.38832775552166 0.0825186320885844 no 465 0.106225443278387 441 NA FT MITOCHONDRION Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria biological_process molecular_function mitochondrion|lipid particle
YMR154C YMR154C RIM13 hom Verified 1.38077196538108 0.0836745429587939 no 466 0.0891869009112101 442 NA FF|FT ION HOMEOSTASIS|PROTEOLYSIS|ION HOMEOSTASIS Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB protein processing cysteine-type endopeptidase activity cellular_component
YPL069C YPL069C BTS1 hom Verified 1.3793517132909 0.0838931696930264 no 467 0.20974695130626 751 NA FF|FT PROTEIN LOCALIZATION|LIPID METABOLISM MITOCHONDRION Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic terpenoid biosynthetic process farnesyltranstransferase activity mitochondrion
YNL288W YNL288W CAF40 hom Verified 1.37714904608831 0.0842330858071269 no 468 0.0895816192342778 346 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter molecular_function CCR4-NOT core complex
YKR094C YKR094C RPL40B hom Verified 1.37434180687463 0.0846677965338337 no 469 0.0818148557126405 319 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RESPONSE TO DNA DAMAGE|TRANSLATION NUCLEUS|MITOCHONDRION RIBOSOME Ubiquitin-ribosomal 60S subunit protein L40B fusion protein; cleaved to yield ubiquitin and ribosomal protein L40B; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40B has a paralog, RPL40A, that arose from the whole genome duplication cytoplasmic translation|protein ubiquitination|ribosome biogenesis structural constituent of ribosome|protein tag mitochondrion|cytosolic large ribosomal subunit
YJL108C YJL108C PRM10 hom Verified 1.37140772411972 0.085123945477531 no 470 0.0974954430543486 349 NA Pheromone-regulated protein, proposed to be involved in mating; predicted to have 5 transmembrane segments; induced by treatment with 8-methoxypsoralen and UVA irradiation biological_process molecular_function integral to membrane
YLR058C YLR058C SHM2 hom Verified 1.37076072217539 0.0852247793976646 no 471 0.0803179438120826 301 NA FT KETONE METABOLISM|AMINO ACID METABOLISM SITE OF POLARIZED GROWTH Cytosolic serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis one-carbon metabolic process glycine hydroxymethyltransferase activity plasma membrane|mating projection tip|cytoplasm
YGL156W YGL156W AMS1 hom Verified 1.3703686191923 0.0852859313770791 no 472 0.0819642798790838 301 NA FT CARBOHYDRATE METABOLISM Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway oligosaccharide catabolic process|cellular carbohydrate metabolic process alpha-mannosidase activity fungal-type vacuole membrane
YNL336W YNL336W COS1 hom Verified 1.36876324215946 0.0855366471856752 no 473 0.0894768019406398 357 NA Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins biological_process molecular_function integral to membrane|fungal-type vacuole
YLR185W YLR185W RPL37A hom Verified 1.36624893776198 0.0859304210143966 no 474 0.080305308341033 296 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L37A; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37A has a paralog, RPL37B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YBR219C_p YBR219C YBR219C hom Uncharacterized 1.3657296425289 0.0860119183785005 no 475 0.0806464092970519 301 NA Putative protein of unknown function; YBR219C is not an essential gene biological_process molecular_function integral to membrane
YMR160W YMR160W YMR160W hom Verified 1.36484076911425 0.0861515509499948 no 476 0.0870002828492183 371 NA Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; mutant has enhanced sensitivity to overexpression of mutant huntingtin; YMR160W is not an essential gene; relative distribution within the vacuolar membrane changes upon DNA replication stress biological_process molecular_function fungal-type vacuole membrane
YFL013C YFL013C IES1 hom Verified 1.36182547635769 0.0866264847352155 no 477 0.111859701910537 411 NA FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Subunit of the INO80 chromatin remodeling complex nucleosome mobilization molecular_function nucleus|Ino80 complex
YDL070W YDL070W BDF2 hom Verified 1.36109376086076 0.0867420305495595 no 478 0.0787879229756699 337 NA FT CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS Protein involved in transcription initiation; acts at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf1p; protein abundance increases in response to DNA replication stress negative regulation of heterochromatin assembly histone acetyl-lysine binding|core promoter binding|histone binding|TFIID-class transcription factor binding nucleus
YHR086W-A_p YHR086W-A YHR086W-A hom Uncharacterized 1.36032430413922 0.0868636603077585 no 479 0.0811201423054219 330 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YCL011C YCL011C GBP2 hom Verified 1.35106039594621 0.0883380433114382 no 480 0.108300331841897 402 NA FT RNA LOCALIZATION NUCLEUS|CHROMOSOME Poly(A+) RNA-binding protein; involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Npl3p; also binds single-stranded telomeric repeat sequence in vitro; GBP2 has a paralog, HRB1, that arose from the whole genome duplication poly(A)+ mRNA export from nucleus|telomere maintenance RNA binding|telomeric DNA binding nucleus|cytoplasmic stress granule
YEL041W YEL041W YEF1 hom Verified 1.34645733745357 0.0890775351169443 no 481 0.112087981097274 395 NA FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM ATP-NADH kinase; phosphorylates both NAD and NADH; homooctameric structure consisting of 60-kDa subunits; similar to Pos5p; overexpression complements certain pos5 phenotypes; YEF1 has a paralog, UTR1, that arose from the whole genome duplication NADP biosynthetic process NAD+ kinase activity|NADH kinase activity cellular_component
YNL233W YNL233W BNI4 hom Verified 1.34618490385235 0.0891214461718484 no 482 0.119997540114456 442 NA FT PROTEIN LOCALIZATION|CELL DIVISION|CARBOHYDRATE METABOLISM SITE OF POLARIZED GROWTH|CYTOSKELETON Targeting subunit for Glc7p protein phosphatase, localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p asymmetric protein localization|barrier septum assembly|chitin biosynthetic process protein binding incipient cellular bud site|cellular bud neck septin collar|cellular bud neck|septin ring
YPL200W YPL200W CSM4 hom Verified 1.3448676032324 0.0893339969706029 no 483 0.0882116000441396 348 NA FT CELL CYCLE|CHROMOSOME SEGREGATION ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|CHROMOSOME Protein required for accurate chromosome segregation during meiosis; involved in meiotic telomere clustering (bouquet formation) and telomere-led rapid prophase movements meiotic telomere clustering|meiotic chromosome segregation|synapsis|regulation of reciprocal meiotic recombination molecular_function nuclear chromosome, telomeric region|endoplasmic reticulum membrane
YMR078C YMR078C CTF18 hom Verified 1.34441102262085 0.0894077556963485 no 484 0.0740510534253059 317 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS|MITOCHONDRION|CHROMOSOME Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint maintenance of DNA trinucleotide repeats|double-strand break repair via homologous recombination|DNA replication initiation|mitotic sister chromatid cohesion molecular_function mitochondrion|nuclear replication fork|Ctf18 RFC-like complex
YOR314W_d YOR314W YOR314W hom Dubious 1.34189339648883 0.0898152815908962 no 485 0.0858889921204609 342 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR271C_d YDR271C YDR271C hom Dubious 1.34081705727902 0.0899899283692573 no 486 0.124104470067978 476 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W Unknown Unknown Unknown
YOL073C YOL073C YOL073C hom Verified 1.3401837839074 0.0900928011397672 no 487 0.0868042035693403 323 NA Subunit of the DSC ubiquitin ligase complex; ortholog of fission yeast dsc2 biological_process molecular_function integral to membrane
YNL204C YNL204C SPS18 hom Verified 1.34011407398442 0.0901041305788405 no 488 0.101672010196715 386 NA FT SIGNALING|NUCLEOTIDE METABOLISM Protein of unknown function, contains a putative zinc-binding domain; expressed during sporulation sporulation resulting in formation of a cellular spore molecular_function cellular_component
YFL041W-A_p YFL041W-A YFL041W-A hom Uncharacterized 1.33866579388125 0.0903397483396274 no 489 0.0909606088490717 340 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YPR127W YPR127W YPR127W hom Verified 1.3378872825296 0.0904665917089671 no 490 0.082997794130964 379 NA FT OXIDATION-REDUCTION PROCESS NUCLEUS Putative pyridoxine 4-dehydrogenase; differentially expressed during alcoholic fermentation; expression activated by transcription factor YRM1/YOR172W; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus biological_process molecular_function nucleus|cytoplasm
YCR020W-B YCR020W-B HTL1 hom Verified 1.33769974504867 0.090497167068756 no 491 0.112020394726517 425 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS RSC COMPLEX Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance regulation of cell cycle|nucleosome disassembly|response to DNA damage stimulus|chromatin remodeling|transcription elongation from RNA polymerase II promoter chromatin binding RSC complex
YBR246W YBR246W RRT2 hom Verified 1.33549219046051 0.0908576547903104 no 492 0.109946580419025 451 NA FT VESICLE-MEDIATED TRANSPORT Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription peptidyl-diphthamide biosynthetic process from peptidyl-histidine|endocytic recycling molecular_function endosome|cytoplasm
YLR123C_d YLR123C YLR123C hom Dubious 1.33296593153777 0.0912714920820143 no 493 0.0739182252317128 295 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif Unknown Unknown Unknown
YOR187W YOR187W TUF1 hom Verified 1.33125328614292 0.0915528416822791 no 494 0.166954456377902 507 NA FT TRANSLATION|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial translation elongation factor Tu; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans mitochondrial translational elongation|mitochondrial translation GTPase activity|translation elongation factor activity mitochondrion|mitochondrial matrix
YEL042W YEL042W GDA1 hom Verified 1.33028980975668 0.0917114016741714 no 495 0.0856805362203698 335 NA FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate protein glycosylation guanosine-diphosphatase activity|uridine-diphosphatase activity Golgi apparatus
YGL020C YGL020C GET1 hom Verified 1.32870881436715 0.0919720278899449 no 496 0.137375995599133 538 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance retrograde vesicle-mediated transport, Golgi to ER|protein insertion into ER membrane protein anchor mitochondrion|integral to membrane|endoplasmic reticulum|GET complex
YIL154C YIL154C IMP2' hom Verified 1.32748612697272 0.0921739630318261 no 497 0.148437338611459 598 NA FF|FT RESPONSE TO DNA DAMAGE|ION HOMEOSTASIS|CARBOHYDRATE METABOLISM|ION HOMEOSTASIS Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeat DNA repair|cellular carbohydrate metabolic process transcription coactivator activity cytoplasm
YBR027C_d YBR027C YBR027C hom Dubious 1.32400443029751 0.0927507866787315 no 498 0.0735644423522885 328 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YBR141C_p YBR141C YBR141C hom Uncharacterized 1.32324640503406 0.0928767242194947 no 499 0.0821918372151933 324 NA FT NUCLEUS Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YBR141C is not an essential gene biological_process S-adenosylmethionine-dependent methyltransferase activity nucleolus
YIL148W YIL148W RPL40A hom Verified 1.32049919751657 0.0933342018905075 no 500 0.0984560649212743 366 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RESPONSE TO DNA DAMAGE|TRANSLATION NUCLEUS RIBOSOME Ubiquitin-ribosomal 60S subunit protein L40A fusion protein; cleaved to yield ubiquitin and ribosomal protein L40A; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40A has a paralog, RPL40B, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress cytoplasmic translation|protein ubiquitination|ribosome biogenesis structural constituent of ribosome|protein tag cytosolic large ribosomal subunit
YBL075C YBL075C SSA3 hom Verified 1.31966938594459 0.0934727127697134 no 501 0.101769442536712 450 NA FT PROTEIN LOCALIZATION ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm; SSA3 has a paralog, SSA4, that arose from the whole genome duplication protein folding|SRP-dependent cotranslational protein targeting to membrane, translocation|response to stress unfolded protein binding|ATPase activity cytosol
YGR021W_p YGR021W YGR021W hom Uncharacterized 1.31673675540205 0.0939634393740263 no 502 0.103174698037756 385 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YJL092W YJL092W SRS2 hom Verified 1.31563269514106 0.0941486771356797 no 503 0.0970286945219162 426 NA FT RESPONSE TO DNA DAMAGE NUCLEUS DNA helicase and DNA-dependent ATPase involved in DNA repair and checkpoint recovery, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability DNA repair|double-strand break repair via nonhomologous end joining|DNA duplex unwinding DNA helicase activity nucleus
YCL064C YCL064C CHA1 hom Verified 1.31407927704801 0.0944097635420179 no 504 0.0941863792890384 342 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine threonine catabolic process|L-serine catabolic process L-threonine ammonia-lyase activity|L-serine ammonia-lyase activity mitochondrial nucleoid|mitochondrion
YOL067C YOL067C RTG1 hom Verified 1.31400498238207 0.0944222637747904 no 505 0.12124414504754 450 NA FT TRANSCRIPTION FROM RNA POL II|SIGNALING NUCLEUS Transcription factor (bHLH) involved in interorganelle communication between mitochondria, peroxisomes, and nucleus cellular response to oleic acid|positive regulation of transcription from RNA polymerase II promoter|mitochondria-nucleus signaling pathway sequence-specific DNA binding RNA polymerase II transcription factor activity nucleus|cytoplasm
YIR018W YIR018W YAP5 hom Verified 1.31269449045036 0.0946429574422092 no 506 0.0823818445918315 332 NA FT TRANSCRIPTION FROM RNA POL II|GENE SILENCING NUCLEUS|CHROMOSOME Basic leucine zipper (bZIP) iron-sensing transcription factor; YAP5 has a paralog, YAP7, that arose from the whole genome duplication negative regulation of chromatin silencing at telomere|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter in response to iron|positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding RNA polymerase II transcription factor activity nuclear chromatin|nucleus
YJR060W YJR060W CBF1 hom Verified 1.3113854135188 0.0948637921815366 no 507 0.124326013723485 487 NA FF|FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|CHROMOSOME SEGREGATION NUCLEUS|MITOCHONDRION|CHROMOSOME KINETOCHORE Dual function helix-loop-helix protein; binds the motif CACRTG present at several sites including MET gene promoters and centromere DNA element I (CDEI); affects nucleosome positioning at this motif; associates with other transcription factors such as Met4p and Isw1p to mediate transcriptional activation or repression; associates with kinetochore proteins and required for efficient chromosome segregation; protein abundance increases in response to DNA replication stress regulation of transcription from RNA polymerase II promoter in response to methionine|negative regulation of transcription from RNA polymerase II promoter|methionine biosynthetic process|chromosome segregation|Unknown|chromatin remodeling|negative regulation of ceramide biosynthetic process by negative regulation of transcription from RNA Polymerase II promoter RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor binding transcription factor activity|RNA polymerase II repressing transcription factor binding|centromeric DNA binding chromosome, centromeric region|mitochondrion|nucleus|kinetochore
YKL053C-A YKL053C-A MDM35 hom Verified 1.31108514483868 0.0949144994957652 no 508 0.105653083722886 413 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION NUCLEUS|MITOCHONDRION Mitochondrial intermembrane space protein; mutation affects mitochondrial distribution and morphology; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress mitochondrion organization|mitochondrial respiratory chain complex assembly molecular_function nucleus|cytoplasm|mitochondrial intermembrane space
YLR143W YLR143W DPH6 hom Verified 1.31070348100976 0.0949789810829769 no 509 0.122316767383881 427 NA Diphthamide synthetase; catalyzes the last amidation step of diphthamide biosynthesis using ammonium and ATP; evolutionarily conserved in eukaryotes; dph6 mutants exhibit diphthine accumulation and resistance to sordarin, which is indicative of defects in diphthamide formation on EF2; green fluorescent protein (GFP)-tagged protein localizes to the cytoplasm; DPH6/YLR143W is not an essential gene biological_process molecular_function cytoplasm
YDR192C YDR192C NUP42 hom Verified 1.30979810040141 0.0951320729747619 no 510 0.0902955736337305 342 NA FT PROTEIN LOCALIZATION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; interacts with Gle1p poly(A)+ mRNA export from nucleus|NLS-bearing substrate import into nucleus|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|mRNA export from nucleus in response to heat stress|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery nucleocytoplasmic transporter activity|structural constituent of nuclear pore nuclear pore central transport channel|integral to membrane|nuclear pore cytoplasmic filaments|nuclear pore
YGL028C YGL028C SCW11 hom Verified 1.30932443795171 0.0952122374970246 no 511 0.104856997381476 371 NA FT CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p cytokinesis, completion of separation glucan endo-1,3-beta-D-glucosidase activity fungal-type cell wall
YBL048W_d YBL048W RRT1 hom Dubious 1.30614014469241 0.0957524515960852 no 512 0.115877385227956 464 NA Identified in a screen for mutants with increased levels of rDNA transcription; dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data Unknown Unknown Unknown
YDR132C YDR132C YDR132C hom Verified 1.30610011931646 0.0957592562053729 no 513 0.0864773349271318 295 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS NUCLEUS|PLASMA MEMBRANE Protein of unknown function; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; YDR132C has a paralog, YLR108C, that arose from the whole genome duplication biological_process molecular_function nucleus|cytoplasm
YDL095W YDL095W PMT1 hom Verified 1.30592066493391 0.095789769147784 no 514 0.126827415362111 427 NA FT PROTEIN LOCALIZATION|CARBOHYDRATE METABOLISM|PROTEOLYSIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein O-mannosyltransferase of the ER membrane; transfers mannose from dolichyl phosphate-D-mannose to protein serine and threonine residues; 1 of 7 related proteins involved in O-glycosylation which is essential for cell wall rigidity; involved in ER quality control; amino terminus faces cytoplasm, carboxyl terminus faces ER lumen ER-associated misfolded protein catabolic process|Unknown|protein exit from endoplasmic reticulum|protein O-linked mannosylation dolichyl-phosphate-mannose-protein mannosyltransferase activity integral to membrane|dolichyl-phosphate-mannose-protein mannosyltransferase complex
YNL020C YNL020C ARK1 hom Verified 1.30445301057206 0.0960395854664129 no 515 0.0835969525502933 346 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION SITE OF POLARIZED GROWTH|CYTOSKELETON Serine/threonine protein kinase; involved in regulation of the cortical actin cytoskeleton; involved in control of endocytosis; ARK1 has a paralog, PRK1, that arose from the whole genome duplication regulation of endocytosis|actin filament organization|protein phosphorylation|cytokinesis|actin cortical patch assembly protein serine/threonine kinase activity|protein kinase activity mating projection tip|actin cortical patch
YBR086C YBR086C IST2 hom Verified 1.30315843811504 0.0962603380631941 no 516 0.107587094149156 367 NA FT PLASMA MEMBRANE Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localizes to the mother cell in small-budded cells and to the bud in medium- and large-budded cells; mRNA is transported to the bud tip by an actomyosin-driven process response to osmotic stress lipid binding integral to membrane|cellular bud membrane|plasma membrane
YGR187C YGR187C HGH1 hom Verified 1.30202643776808 0.0964536740499863 no 517 0.0939246412069348 379 NA Nonessential protein of unknown function; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16); relative distribution to the nucleus increases upon DNA replication stress biological_process molecular_function cytoplasm
YMR142C YMR142C RPL13B hom Verified 1.3004744746901 0.096719199600618 no 518 0.108946010604882 421 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L13B; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13B has a paralog, RPL13A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YCL061C YCL061C MRC1 hom Verified 1.30018865180812 0.0967681595550327 no 519 0.118434422974383 505 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION|GENE SILENCING NUCLEUS|CHROMOSOME S-phase checkpoint protein required for DNA replication; interacts with and stabilizes Pol2p at stalled replication forks during stress, where it forms a pausing complex with Tof1p and is phosphorylated by Mec1p; protects uncapped telomeres maintenance of DNA repeat elements|intra-S DNA damage checkpoint|DNA repair|DNA replication checkpoint|telomere maintenance|replication fork protection|DNA replication|mitotic sister chromatid cohesion|chromatin silencing at silent mating-type cassette|chromatin silencing at telomere molecular_function nuclear chromosome|replication fork protection complex|nucleus|nuclear replication fork
YDR101C YDR101C ARX1 hom Verified 1.29861625165163 0.0970378289282555 no 520 0.106832949000283 351 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|PROTEOLYSIS NUCLEUS RIBOSOME Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex ribosomal large subunit biogenesis molecular_function nucleoplasm|cytosolic large ribosomal subunit|cytoplasm
YGL006W YGL006W PMC1 hom Verified 1.29719352470007 0.097282304079434 no 521 0.0846052237753833 319 NA FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions; prevents growth inhibition by activation of calcineurin in the presence of elevated concentrations of calcium; similar to mammalian PMCA1a cellular calcium ion homeostasis|calcium ion transport|transmembrane transport calcium-transporting ATPase activity fungal-type vacuole membrane|integral to membrane
YML003W_p YML003W YML003W hom Uncharacterized 1.29456232193393 0.0977356285831795 no 522 0.0806160188297136 313 NA Putative protein of unknown function biological_process molecular_function cellular_component
YLR226W YLR226W BUR2 hom Verified 1.29317010458152 0.0979761164419558 no 523 0.103064697045088 387 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|PROTEIN PHOSPHORYLATION|CHROMOSOME SEGREGATION NUCLEUS Cyclin for the Sgv1p (Bur1p) protein kinase; Sgv1p and Bur2p comprise a CDK-cyclin complex involved in transcriptional regulation through its phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II phosphorylation of RNA polymerase II C-terminal domain|positive regulation of histone ubiquitination|transcription, DNA-dependent|positive regulation of histone H3-K4 methylation|mitotic sister chromatid segregation cyclin-dependent protein kinase regulator activity cyclin-dependent protein kinase holoenzyme complex|nucleus
YDR495C YDR495C VPS3 hom Verified 1.29190593266395 0.0981948614758656 no 524 0.131591323087772 524 NA FF|FT PROTEIN LOCALIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT Component of CORVET tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase vacuole inheritance|vacuolar acidification|protein targeting to vacuole molecular_function CORVET complex|cytoplasm
YJR040W YJR040W GEF1 hom Verified 1.29161747519202 0.098244824588375 no 525 0.105120689250239 465 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS ENDOPLASMIC RETICULUM|GOLGI APPARATUS|PLASMA MEMBRANE Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism cellular copper ion homeostasis|cellular iron ion homeostasis voltage-gated chloride channel activity endosome|integral to membrane|endoplasmic reticulum|Golgi apparatus|plasma membrane|fungal-type vacuole|Golgi medial cisterna
YPR087W_d YPR087W VPS69 hom Dubious 1.2899400044509 0.0985357448149307 no 526 0.120289948978256 451 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene SRP54; deletion causes a vacuolar protein sorting defect Unknown Unknown Unknown
YJL063C YJL063C MRPL8 hom Verified 1.28931698302408 0.098643954574615 no 527 0.120261265439859 489 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial genome maintenance|mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YDR297W YDR297W SUR2 hom Verified 1.28887942824338 0.0987200034545948 no 528 0.11238320443256 415 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis sphingolipid metabolic process sphingosine hydroxylase activity integral to membrane|endoplasmic reticulum membrane
YLR114C YLR114C AVL9 hom Verified 1.28783168939091 0.0989022792904331 no 529 0.109150523802904 369 NA FT VESICLE-MEDIATED TRANSPORT Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress post-Golgi vesicle-mediated transport molecular_function cytoplasm
YKL031W_d YKL031W YKL031W hom Dubious 1.28666082392443 0.0991062667483099 no 530 0.104436656207287 349 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species Unknown Unknown Unknown
YLR261C_d YLR261C VPS63 hom Dubious 1.28628913740431 0.0991710860447623 no 531 0.203370865629728 660 NA FF Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect Unknown Unknown Unknown
YOR175C YOR175C ALE1 hom Verified 1.28543589987372 0.0993200014287403 no 532 0.10307259945806 395 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Broad-specificity lysophospholipid acyltransferase, part of MBOAT family of membrane-bound O-acyltransferases; key component of Lands cycle; may have role in fatty acid exchange at sn-2 position of mature glycerophospholipids glycerophospholipid biosynthetic process 1-acylglycerophosphocholine O-acyltransferase activity|O-acyltransferase activity|1-acylglycerol-3-phosphate O-acyltransferase activity integral to membrane|ribosome|endoplasmic reticulum
YBL080C YBL080C PET112 hom Verified 1.28543418420768 0.0993203010282109 no 533 0.13137790023544 500 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; mutation is functionally complemented by the bacterial GatB ortholog glutaminyl-tRNAGln biosynthesis via transamidation|mitochondrial translation glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity mitochondrion|glutamyl-tRNA(Gln) amidotransferase complex
YBL071W-A YBL071W-A KTI11 hom Verified 1.28507264158349 0.099383450421833 no 534 0.141683097305462 543 NA FT RNA PROCESSING NUCLEUS Zn-ribbon protein that co-purifies with Dph1 and Dph2 in a complex required for synthesis of diphthamide on translation factor eEF2 and with Elongator subunits Iki3p, Elp2p, and Elp3p involved in modification of wobble nucleosides in tRNAs peptidyl-diphthamide biosynthetic process from peptidyl-histidine|tRNA wobble uridine modification electron carrier activity|iron ion binding|zinc ion binding nucleus|cytoplasm
YGR097W YGR097W ASK10 hom Verified 1.28373525698291 0.0996173018421677 no 535 0.099186130817041 335 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO OXIDATIVE STRESS NUCLEUS RNA POL II, HOLOENZYME Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication cellular protein catabolic process|cellular response to oxidative stress|positive regulation of transcription from RNA polymerase II promoter|positive regulation of glycerol transport molecular_function DNA-directed RNA polymerase II, holoenzyme|cytoplasm
YNL123W YNL123W NMA111 hom Verified 1.28323415032754 0.0997050274582829 no 536 0.129551070765649 503 NA FT LIPID METABOLISM|PROTEOLYSIS NUCLEUS Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases apoptotic process|cellular lipid metabolic process|protein catabolic process|cellular response to heat serine-type peptidase activity nucleus
YBL061C YBL061C SKT5 hom Verified 1.28289011659645 0.0997652879659873 no 537 0.111151398225714 482 NA FT CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON Activator of Chs3p (chitin synthase III) during vegetative growth; recruits Chs3p to the bud neck via interaction with Bni4p; SKT5 has a paralog, SHC1, that arose from the whole genome duplication fungal-type cell wall chitin biosynthetic process|response to osmotic stress|cytokinesis enzyme activator activity incipient cellular bud site|cellular bud neck septin ring|cellular bud neck
YGR201C_p YGR201C YGR201C hom Uncharacterized 1.28068788902359 0.100151657685285 no 538 0.0794884304942429 321 NA Putative protein of unknown function biological_process molecular_function cellular_component
YER077C_p YER077C YER077C hom Uncharacterized 1.28024503775473 0.100229485452109 no 539 0.141604010987337 501 NA FT MITOCHONDRION Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport biological_process molecular_function mitochondrion
YJL016W_p YJL016W YJL016W hom Uncharacterized 1.27836247433046 0.100560824498778 no 540 0.109557120950618 400 NA Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; conserved in closely related Saccharomyces species biological_process molecular_function cytoplasm
YPR070W YPR070W MED1 hom Verified 1.27739207878888 0.100731929958147 no 541 0.12844780643996 509 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter molecular_function core mediator complex
YNL218W YNL218W MGS1 hom Verified 1.27713506693692 0.100777283240476 no 542 0.0652252808207467 254 NA FT RESPONSE TO DNA DAMAGE NUCLEUS Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress regulation of DNA repair|DNA replication, Okazaki fragment processing|DNA strand renaturation ubiquitin binding|single-stranded DNA-dependent ATPase activity|enzyme activator activity nucleus|cytoplasm
YDR417C_d YDR417C YDR417C hom Dubious 1.27645629476398 0.100897133534196 no 543 0.108825875648062 370 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RPL12B/YDR418W Unknown Unknown Unknown
YOR227W YOR227W HER1 hom Verified 1.27527079909549 0.101106704801614 no 544 0.108960147204888 390 NA FT MITOCHONDRION Protein of unknown function required for proliferation or remodeling of the ER that is caused by overexpression of Hmg2p; may interact with ribosomes, based on co-purification experiments; HER1 has a paralog, GIP3, that arose from the whole genome duplication endoplasmic reticulum organization molecular_function mitochondrion|ribosome|cytoplasm
YLR031W_p YLR031W YLR031W hom Uncharacterized 1.27523620881996 0.101112824411228 no 545 0.112918279724707 424 NA Putative protein of unknown function biological_process molecular_function cellular_component
YER076C_p YER076C YER076C hom Uncharacterized 1.27523496909863 0.101113043744082 no 546 0.096421041002037 329 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; analysis of HA-tagged protein suggests a membrane localization biological_process molecular_function mitochondrion
YPL041C_p YPL041C YPL041C hom Uncharacterized 1.27441750050465 0.101257746691793 no 547 0.0973983486679695 300 NA Protein of unknown function involved in maintenance of proper telomere length biological_process molecular_function cellular_component
YJL172W YJL172W CPS1 hom Verified 1.27250919707021 0.101596129215621 no 548 0.11885537808746 360 NA FT PROTEOLYSIS Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions nitrogen compound metabolic process|proteolysis involved in cellular protein catabolic process carboxypeptidase activity fungal-type vacuole lumen
YDL136W YDL136W RPL35B hom Verified 1.2718222151927 0.101718146974624 no 549 0.111654276002766 437 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal 60S subunit protein L35B; homologous to mammalian ribosomal protein L35 and bacterial L29; RPL35B has a paralog, RPL35A, that arose from the whole genome duplication cytoplasmic translation|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic large ribosomal subunit|preribosome, large subunit precursor
YPR131C YPR131C NAT3 hom Verified 1.27158472017051 0.101760354278237 no 550 0.100012342102738 394 NA FT MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION Catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met mitochondrion inheritance|N-terminal peptidyl-methionine acetylation|cytoskeleton organization peptide alpha-N-acetyltransferase activity NatB complex|cytoplasm
YNR005C_d YNR005C YNR005C hom Dubious 1.27065736355038 0.10192528496945 no 551 0.124314142816271 489 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGR257C YGR257C MTM1 hom Verified 1.26813961115201 0.102374049018121 no 552 0.138376372745734 546 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor manganese ion transport|transport transporter activity|metallochaperone activity mitochondrion|integral to membrane|mitochondrial inner membrane
YPR027C_p YPR027C YPR027C hom Uncharacterized 1.26398728676307 0.10311729504904 no 553 0.124691155532259 496 NA Putative protein of unknown function biological_process molecular_function cellular_component
YDR245W YDR245W MNN10 hom Verified 1.26382009103634 0.103147304139243 no 554 0.111953336276801 432 NA FT CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Subunit of a Golgi mannosyltransferase complex also containing Anp1p, Mnn9p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltransferase family N-glycan processing|cell wall mannoprotein biosynthetic process|substituted mannan metabolic process|barrier septum assembly alpha-1,6-mannosyltransferase activity alpha-1,6-mannosyltransferase complex
YKL041W YKL041W VPS24 hom Verified 1.26361190628385 0.103184679000661 no 555 0.120656185824408 476 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); forms an ESCRT-III subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway intralumenal vesicle formation|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|late endosome to vacuole transport molecular_function ESCRT III complex|cytoplasm
YMR264W YMR264W CUE1 hom Verified 1.26318300200284 0.10326171005785 no 556 0.124226942654815 513 NA FF|FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|PROTEOLYSIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION UBIQUITIN LIGASE COMPLEX Ubiquitin-binding protein; endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination; CUE1 has a paralog, CUE4, that arose from the whole genome duplication ER-associated protein catabolic process|establishment of protein localization to endoplasmic reticulum membrane ubiquitin-protein ligase activator activity Doa10p ubiquitin ligase complex|mitochondrion|integral to endoplasmic reticulum membrane
YDL118W_d YDL118W YDL118W hom Dubious 1.26280514990554 0.103329606748477 no 557 0.139276496372181 559 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS Dubious open reading frame, unlikely to encode a protein; overlaps almost completely with YDL119C; mutations that would affect both YDL118W and YDL119C confer defective telomere maintenance and are synthetically sick or lethal with alpha-synuclein biological_process molecular_function cellular_component
YPL156C YPL156C PRM4 hom Verified 1.26015521350386 0.103806687818573 no 558 0.0784415953570486 345 NA Pheromone-regulated protein proposed to be involved in mating; predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift biological_process molecular_function integral to membrane
YMR097C YMR097C MTG1 hom Verified 1.25865939896702 0.104076691155548 no 559 0.122369576420818 483 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Putative GTPase peripheral to the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals mitochondrial translation GTPase activity mitochondrion|mitochondrial inner membrane
YBR014C YBR014C GRX7 hom Verified 1.25720020527215 0.104340574498648 no 560 0.0888896457732204 395 NA FT RESPONSE TO OXIDATIVE STRESS GOLGI APPARATUS Cis-golgi localized monothiol glutaredoxin; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; does not bind metal ions; GRX7 has a paralog, GRX6, that arose from the whole genome duplication cellular response to oxidative stress glutathione-disulfide reductase activity|protein homodimerization activity integral to membrane|Golgi apparatus|Golgi lumen|fungal-type vacuole|cis-Golgi network
YCL058C YCL058C FYV5 hom Verified 1.25651124036664 0.104465336590497 no 561 0.104962312839769 405 NA FT SIGNALING|ION HOMEOSTASIS|ION HOMEOSTASIS Protein involved in regulation of the mating pathway; binds with Matalpha2p to promoters of haploid-specific genes; required for survival upon exposure to K1 killer toxin; involved in ion homeostasis pheromone-dependent signal transduction involved in conjugation with cellular fusion|cellular ion homeostasis molecular_function integral to membrane
YLR460C_p YLR460C YLR460C hom Uncharacterized 1.25523207083015 0.104697263214367 no 562 0.0961467860666959 387 NA FT OXIDATION-REDUCTION PROCESS Member of the quinone oxidoreductase family, up-regulated in response to the fungicide mancozeb; possibly up-regulated by iodine biological_process molecular_function cellular_component
YGR192C YGR192C TDH3 hom Verified 1.25484818812877 0.104766937801505 no 563 0.11011463616453 415 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Glyceraldehyde-3-phosphate dehydrogenase, isozyme 3; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; TDH3 has a paralog, TDH2, that arose from the whole genome duplication gluconeogenesis|reactive oxygen species metabolic process|glycolysis|apoptotic process glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity mitochondrion|fungal-type cell wall|lipid particle|plasma membrane|cytoplasm
YGR270W YGR270W YTA7 hom Verified 1.25473794119632 0.104786953789217 no 564 0.152604263592038 502 NA FT TRANSCRIPTION FROM RNA POL II|GENE SILENCING ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Protein that localizes to chromatin and has a role in regulation of histone gene expression; has a bromodomain-like region that interacts with the N-terminal tail of histone H3, and an ATPase domain; potentially phosphorylated by Cdc28p negative regulation of transcription from RNA polymerase II promoter|negative regulation of chromatin silencing|positive regulation of transcription from RNA polymerase II promoter chromatin binding|histone binding extrinsic to endoplasmic reticulum membrane|nucleus
YLR092W YLR092W SUL2 hom Verified 1.25442474956642 0.104843830703382 no 565 0.0979890216919952 380 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates sulfate transport sulfate transmembrane transporter activity integral to membrane|plasma membrane
YOR270C YOR270C VPH1 hom Verified 1.25367968658211 0.104979227101011 no 566 0.112395383135098 391 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS Subunit a of vacuolar-ATPase V0 domain; one of two isoforms (Vph1p and Stv1p); Vph1p is located in V-ATPase complexes of the vacuole while Stv1p is located in V-ATPase complexes of the Golgi and endosomes; relative distribution to the vacuolar membrane decreases upon DNA replication stress polyphosphate metabolic process|proton transport|protein complex assembly|vacuolar acidification proton-transporting ATPase activity, rotational mechanism vacuolar proton-transporting V-type ATPase, V0 domain|fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YIL028W_d YIL028W YIL028W hom Dubious 1.2536271006896 0.104988788039893 no 567 0.118274247668754 369 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YNR036C YNR036C MRPS12 hom Verified 1.24923848668881 0.105788929583379 no 568 0.117923529369258 466 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial protein; may interact with ribosomes based on co-purification experiments; similar to E. coli and human mitochondrial S12 ribosomal proteins mitochondrial translation structural constituent of ribosome mitochondrion|ribosome|mitochondrial small ribosomal subunit
YBR184W_p YBR184W YBR184W hom Uncharacterized 1.24852055349481 0.1059202431329 no 569 0.103216625953461 423 NA Putative protein of unknown function; YBR184W is not an essential gene biological_process molecular_function cellular_component
YCR061W_p YCR061W YCR061W hom Uncharacterized 1.24802830869237 0.106010345199712 no 570 0.110816061694251 457 NA Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; induced by treatment with 8-methoxypsoralen and UVA irradiation regulation of cell size molecular_function integral to membrane|cytoplasm
YNL328C YNL328C MDJ2 hom Verified 1.24647286221344 0.106295423083523 no 571 0.125853837751979 436 NA FT PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Constituent of the mitochondrial import motor associated with the presequence translocase; function overlaps with that of Pam18p; stimulates the ATPase activity of Ssc1p to drive mitochondrial import; contains a J domain protein import into mitochondrial matrix protein transporter activity|ATPase activator activity mitochondrial inner membrane|presequence translocase-associated import motor
YKL115C_d YKL115C YKL115C hom Dubious 1.24341100035896 0.106858209356609 no 572 0.0994054553887757 403 NA Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1 Unknown Unknown Unknown
YLR357W YLR357W RSC2 hom Verified 1.24327680302493 0.106882924614888 no 573 0.111010311845297 421 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS RSC COMPLEX Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenance ATP-dependent chromatin remodeling|chromosome segregation|nucleosome disassembly|plasmid maintenance|sister chromatid cohesion|double-strand break repair via nonhomologous end joining|transcription elongation from RNA polymerase II promoter|double-strand break repair via homologous recombination DNA translocase activity RSC complex
YDL168W YDL168W SFA1 hom Verified 1.24215717052242 0.107089289219228 no 574 0.141535509937542 454 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION Bifunctional alcohol dehydrogenase and formaldehyde dehydrogenase; formaldehyde dehydrogenase activity is glutathione-dependent; functions in formaldehyde detoxification and formation of long chain and complex alcohols, regulated by Hog1p-Sko1p; protein abundance increases in response to DNA replication stress furaldehyde metabolic process|formaldehyde catabolic process|amino acid catabolic process to alcohol via Ehrlich pathway S-(hydroxymethyl)glutathione dehydrogenase activity|hydroxymethylfurfural reductase (NADH) activity|alcohol dehydrogenase (NAD) activity mitochondrion|cytoplasm
YOL019W-A_p YOL019W-A YOL019W-A hom Uncharacterized 1.23944061114201 0.107591184811168 no 575 0.0883267643355914 314 NA Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YMR100W YMR100W MUB1 hom Verified 1.23519507199342 0.10837895644543 no 576 0.125685829773258 437 NA FT CELL DIVISION MYND domain-containing protein required for ubiquitination and turnover of Rpn4p; interacts with Ubr2p (E3) and indirectly with Rad6p (E2); short-lived protein degraded in a Ubr2p/Rad6p dependent manner; similar to the A. nidulans samB gene regulation of cell budding|protein monoubiquitination molecular_function cellular_component
YER005W YER005W YND1 hom Verified 1.23399301103938 0.108602754275279 no 577 0.108280150288558 429 NA FT LIPID METABOLISM|CARBOHYDRATE METABOLISM GOLGI APPARATUS Apyrase with wide substrate specificity, helps prevent inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates that inhibit glycotransferases; partially redundant with Gda1p; mediates adenovirus E4orf4-induced toxicity protein glycosylation nucleoside-triphosphatase activity|nucleoside-diphosphatase activity COPI-coated vesicle|Golgi apparatus|membrane|Golgi membrane
YAL055W YAL055W PEX22 hom Verified 1.23282203741548 0.108821083750287 no 578 0.123875660646967 412 NA FT PROTEIN LOCALIZATION|SIGNALING|PEROXISOME ORGANIZATION Putative peroxisomal membrane protein required for import of peroxisomal proteins, functionally complements a Pichia pastoris pex22 mutation protein import into peroxisome matrix, receptor recycling|protein targeting to peroxisome protein anchor integral to peroxisomal membrane
YBR268W YBR268W MRPL37 hom Verified 1.23228319297354 0.108921657916016 no 579 0.154054539787765 556 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YNR075W YNR075W COS10 hom Verified 1.23155323965095 0.109058008695066 no 580 0.0919396917803788 385 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins endocytosis molecular_function nuclear envelope|integral to membrane|endoplasmic reticulum|cytoplasm
YHR184W YHR184W SSP1 hom Verified 1.22949572627776 0.109442999610667 no 581 0.108509240635379 451 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION Protein involved in the control of meiotic nuclear division and coordination of meiosis with spore formation; transcription is induced midway through meiosis ascospore wall assembly|protein complex assembly molecular_function prospore membrane
YOR308C YOR308C SNU66 hom Verified 1.22902426982397 0.109531353316356 no 582 0.111100470987288 407 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Component of the U4/U6.U5 snRNP complex involved in pre-mRNA splicing via spliceosome; also required for pre-5S rRNA processing and may act in concert with Rnh70p; has homology to human SART-1 maturation of 5S rRNA|mRNA splicing, via spliceosome molecular_function U4/U6 x U5 tri-snRNP complex
YPL118W YPL118W MRP51 hom Verified 1.22466710696598 0.110350336129704 no 583 0.12924426010411 483 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit; MRP51 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences mitochondrial translational initiation|mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YJL153C YJL153C INO1 hom Verified 1.22403950861467 0.110468661873015 no 584 0.12189445758407 421 NA FT LIPID METABOLISM|CARBOHYDRATE METABOLISM Inositol-3-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element inositol biosynthetic process inositol-3-phosphate synthase activity cytoplasm
YDR318W YDR318W MCM21 hom Verified 1.22344707897031 0.110580440433067 no 585 0.136998373023905 519 NA FT CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME KINETOCHORE Component of the kinetochore sub-complex COMA; COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) bridges kinetochore subunits in contact with centromeric DNA with subunits bound to microtubules during kinetochore assembly; involved in minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-O and fission yeast mal2 chromosome segregation|establishment of mitotic sister chromatid cohesion molecular_function COMA complex|condensed nuclear chromosome kinetochore
YMR066W YMR066W SOV1 hom Verified 1.22019974316097 0.111194582111156 no 586 0.130950768987249 487 NA FT MITOCHONDRION Mitochondrial protein of unknown function biological_process molecular_function mitochondrion
YMR090W_p YMR090W YMR090W hom Uncharacterized 1.2190773185922 0.111407423841065 no 587 0.123533556265118 429 NA Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; GFP-fusion protein localizes to the cytoplasm; up-regulated in response to the fungicide mancozeb; not essential for viability biological_process molecular_function cytoplasm
YIL125W YIL125W KGD1 hom Verified 1.21843691111695 0.111528992801383 no 588 0.122882864427322 449 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA tricarboxylic acid cycle|2-oxoglutarate metabolic process oxoglutarate dehydrogenase (succinyl-transferring) activity mitochondrial nucleoid|mitochondrion|mitochondrial matrix|mitochondrial oxoglutarate dehydrogenase complex
YLR445W YLR445W GMC2 hom Verified 1.21640204253551 0.111915903137028 no 589 0.109597971669429 445 NA FT CELL CYCLE Protein involved in meiotic progression; mutants are delayed in meiotic nuclear division and are defective in synaptonemal complex assembly; transcription is regulated by Ume6p and induced in response to alpha factor meiosis|synaptonemal complex organization molecular_function cellular_component
YLL002W YLL002W RTT109 hom Verified 1.21616873100062 0.111960326299777 no 590 0.119002416986658 433 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS Histone acetyltransferase critical for cell survival in the presence of DNA damage during S phase; acetylates H3-K56 and H3-K9; involved in non-homologous end joining and in regulation of Ty1 transposition; interacts physically with Vps75p negative regulation of transposition, RNA-mediated|histone acetylation|double-strand break repair via nonhomologous end joining|response to DNA damage stimulus|regulation of transcription from RNA polymerase II promoter in response to stress H3 histone acetyltransferase activity nucleus
YGR044C YGR044C RME1 hom Verified 1.21493394641203 0.112195642650058 no 591 0.0507975480511244 247 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CELL DIVISION NUCLEUS Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-alpha2 regulator; mediates cell type control of sporulation; relocalizes from nucleus to cytoplasm upon DNA replication stress negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription during meiosis|negative regulation of meiosis|positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription involved in G1/S phase of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity nucleus
YML019W YML019W OST6 hom Verified 1.21441437840493 0.112294763768646 no 592 0.123209514523886 476 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p protein N-linked glycosylation via asparagine|protein complex assembly dolichyl-diphosphooligosaccharide-protein glycotransferase activity oligosaccharyltransferase complex|integral to membrane
YPR031W YPR031W NTO1 hom Verified 1.21424593875227 0.112326911443992 no 593 0.135886921062191 466 NA FT CHROMATIN ORGANIZATION NUCLEUS HISTONE ACETYLTRANSFERASE Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3 histone acetylation histone acetyltransferase activity|methylated histone residue binding nucleus|NuA3 histone acetyltransferase complex|cytoplasm
YBR046C YBR046C ZTA1 hom Verified 1.21356594329191 0.112456759346047 no 594 0.116245441400629 406 NA FT OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS NUCLEUS NADPH-dependent quinone reductase, GFP-tagged protein localizes to the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin cellular response to oxidative stress NADPH:quinone reductase activity|AU-rich element binding|2-alkenal reductase [NAD(P)] activity nucleus|cytoplasm
YJL052W YJL052W TDH1 hom Verified 1.20915859225821 0.113300961249873 no 595 0.152783876215252 525 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress gluconeogenesis|glycolysis glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity mitochondrion|fungal-type cell wall|lipid particle|plasma membrane|cytoplasm
YDR094W_d YDR094W YDR094W hom Dubious 1.20722421443731 0.113672903767223 no 596 0.0842451146253675 328 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2 Unknown Unknown Unknown
YNL043C_d YNL043C YNL043C hom Dubious 1.20551661160192 0.114001964572036 no 597 0.11770069338341 429 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W Unknown Unknown Unknown
YIL054W_p YIL054W YIL054W hom Uncharacterized 1.20329367008792 0.11443134885912 no 598 0.117285696886046 433 NA Protein of unknown function; expressed at both mRNA and protein levels biological_process molecular_function cellular_component
YKL101W YKL101W HSL1 hom Verified 1.2016874973514 0.11474231348373 no 599 0.122379485244701 478 NA FT CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION SITE OF POLARIZED GROWTH|CYTOSKELETON Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p G2/M transition of mitotic cell cycle|regulation of cell cycle|cell shape checkpoint|protein autophosphorylation|protein phosphorylation|septin checkpoint protein kinase activity cellular bud neck|septin ring
YHR026W YHR026W VMA16 hom Verified 1.20075222241857 0.114923665038486 no 600 0.20991766949999 681 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS Subunit c'' of the vacuolar ATPase, which functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domain vacuolar acidification proton-transporting ATPase activity, rotational mechanism vacuolar proton-transporting V-type ATPase, V0 domain|integral to membrane
YDL056W YDL056W MBP1 hom Verified 1.19804546653479 0.115449658568622 no 601 0.127834787697019 478 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE NUCLEUS Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes positive regulation of transcription involved in G1/S phase of mitotic cell cycle sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription MBF transcription complex|nucleus
YDR080W YDR080W VPS41 hom Verified 1.19797120030644 0.115464114514377 no 602 0.117973116784569 465 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|VACUOLAR PROTEIN PROCESSING Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport regulation of SNARE complex assembly|regulation of vacuole fusion, non-autophagic|piecemeal microautophagy of nucleus|vacuole organization|vesicle-mediated transport|protein transport|vacuole fusion, non-autophagic|vacuolar protein processing Rab guanyl-nucleotide exchange factor activity|phosphatidylinositol binding endosome|fungal-type vacuole membrane|HOPS complex
YLR329W YLR329W REC102 hom Verified 1.19011931654473 0.116999749540855 no 603 0.132481459215273 455 NA FT CELL CYCLE NUCLEUS|CHROMOSOME Protein involved in early stages of meiotic recombination; required for chromosome synapsis; forms a complex with Rec104p and Spo11p necessary during the initiation of recombination meiotic DNA double-strand break formation|reciprocal meiotic recombination molecular_function condensed nuclear chromosome|nucleus
YBR251W YBR251W MRPS5 hom Verified 1.18835806677909 0.117346184854994 no 604 0.164300588645208 572 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YCR107W YCR107W AAD3 hom Verified 1.18752697865999 0.117509910738774 no 605 0.137200089038764 487 NA FT OXIDATION-REDUCTION PROCESS Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role cellular aldehyde metabolic process aryl-alcohol dehydrogenase (NAD+) activity cellular_component
YJL146W YJL146W IDS2 hom Verified 1.18277442242176 0.11844928001165 no 606 0.106054468196 381 NA FT CELL CYCLE NUCLEUS Protein involved in modulation of Ime2p activity during meiosis, appears to act indirectly to promote Ime2p-mediated late meiotic functions; found in growing cells and degraded during sporulation meiosis molecular_function nucleus|cytoplasm
YOR355W YOR355W GDS1 hom Verified 1.17904426688468 0.11919027470671 no 607 0.132767446352169 516 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS|MITOCHONDRION Protein of unknown function, required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies aerobic respiration molecular_function mitochondrion|nucleus|cytoplasm
YML096W_p YML096W YML096W hom Uncharacterized 1.17819215327924 0.119360005038444 no 608 0.136555778066775 491 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Putative protein of unknown function with similarity to asparagine synthetases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YML096W is not an essential gene and partially overlaps the verified gene RAD10 biological_process molecular_function cytoplasm
YJL132W_p YJL132W YJL132W hom Uncharacterized 1.17789909773733 0.119418417419642 no 609 0.113044500623821 402 NA Putative protein of unknown function; localizes to the membrane fraction; possible Zap1p-regulated target gene induced by zinc deficiency; YJL132W is a non-essential gene biological_process molecular_function membrane
YOR346W YOR346W REV1 hom Verified 1.17768014004202 0.11946207364157 no 610 0.0993891401245907 355 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION|CHROMOSOME Deoxycytidyl transferase; involved in repair of abasic sites and adducted guanines in damaged DNA by translesion synthesis (TLS); forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; relocalizes from nucleus to cytoplasm upon DNA replication stress error-prone translesion synthesis|error-free translesion synthesis deoxycytidyl transferase activity|DNA-directed DNA polymerase activity nuclear chromatin|mitochondrion|replication fork
YKL134C YKL134C OCT1 hom Verified 1.17712190661278 0.119573426280609 no 611 0.12230700089533 471 NA FT PROTEIN LOCALIZATION|ION HOMEOSTASIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS MITOCHONDRION Mitochondrial intermediate peptidase, cleaves destabilizing N-terminal residues of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may contribute to mitochondrial iron homeostasis cellular iron ion homeostasis|protein processing involved in protein targeting to mitochondrion metalloendopeptidase activity mitochondrion
YLR288C YLR288C MEC3 hom Verified 1.17672086496417 0.119653468543315 no 612 0.0969447741933732 345 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|GENE SILENCING NUCLEUS|CHROMOSOME DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1 telomere maintenance via recombination|DNA damage checkpoint|DNA metabolic process|chromatin silencing at telomere DNA binding nucleus|checkpoint clamp complex
YDL019C YDL019C OSH2 hom Verified 1.17511110986827 0.119975133222984 no 613 0.149028730457525 492 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability endocytosis|maintenance of cell polarity|sterol transport|exocytosis lipid binding|oxysterol binding|sterol transporter activity|1-phosphatidylinositol binding endoplasmic reticulum|plasma membrane|cortical endoplasmic reticulum|cellular bud neck
YGL089C YGL089C MF(ALPHA)2 hom Verified 1.17260846242832 0.120476427141703 no 614 0.111078704553048 409 NA FT SIGNALING Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed than MF(ALPHA)2 pheromone-dependent signal transduction involved in conjugation with cellular fusion mating pheromone activity extracellular region
YPL112C YPL112C PEX25 hom Verified 1.1719601189107 0.120606534106718 no 615 0.118359848128668 428 NA FT PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with homologous protein Pex27p protein import into peroxisome matrix|peroxisome organization molecular_function peroxisomal membrane
YLR209C YLR209C PNP1 hom Verified 1.17140216165788 0.120718581896637 no 616 0.130652441940296 433 NA FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM Purine nucleoside phosphorylase, specifically metabolizes inosine and guanosine nucleosides; involved in the nicotinamide riboside salvage pathway guanosine catabolic process|inosine catabolic process|NAD biosynthesis via nicotinamide riboside salvage pathway|nicotinate nucleotide salvage nicotinamide riboside hydrolase activity|inosine nucleosidase activity|purine-nucleoside phosphorylase activity intracellular
YBR272C YBR272C HSM3 hom Verified 1.16915705544479 0.121170179928139 no 617 0.108133482801068 382 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE NUCLEUS Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); involved in DNA mismatch repair during slow growth; weak similarity to Msh1p; related to human 19S subunit S5b; structural study suggests Hsm3p is a scaffold protein for Rpt1p-Rpt2p complex formation mismatch repair|proteasome regulatory particle assembly molecular_function cytosol|proteasome regulatory particle, base subcomplex|nucleus|cytoplasm
YIL009C-A YIL009C-A EST3 hom Verified 1.16684369848202 0.121636748073215 no 618 0.132471073532351 476 NA FT NUCLEUS|CHROMOSOME Component of the telomerase holoenzyme, involved in telomere replication telomere maintenance via telomerase ATP-dependent DNA/RNA helicase activity|GTPase activity|telomeric DNA binding chromosome, telomeric region|nucleus|telomerase holoenzyme complex
YJL096W YJL096W MRPL49 hom Verified 1.16639459221635 0.121727471978459 no 619 0.146639946919828 530 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YNR013C YNR013C PHO91 hom Verified 1.16456916595638 0.122096715478148 no 620 0.134990175399969 435 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth phosphate ion transport|polyphosphate metabolic process phosphate ion transmembrane transporter activity fungal-type vacuole membrane|integral to membrane|membrane
YBR267W YBR267W REI1 hom Verified 1.16436011264601 0.122139052495256 no 621 0.157379054706826 589 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RIBOSOME BIOGENESIS|CELL DIVISION RIBOSOME Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network ribosomal large subunit biogenesis|nucleocytoplasmic transport|mitotic cell cycle|budding cell bud growth sequence-specific DNA binding cytosolic large ribosomal subunit|preribosome, large subunit precursor|cytoplasm
YER117W YER117W RPL23B hom Verified 1.16376073884286 0.122260493499555 no 622 0.118169517831471 482 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L23B; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23B has a paralog, RPL23A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YDL083C YDL083C RPS16B hom Verified 1.16337662094688 0.122338365383191 no 623 0.149406658448129 481 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16B has a paralog, RPS16A, that arose from the whole genome duplication cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit
YLR315W YLR315W NKP2 hom Verified 1.1602922121311 0.122964927103721 no 624 0.161355149227811 514 NA FT CELL CYCLE|CELL DIVISION NUCLEUS|CHROMOSOME|CYTOSKELETON KINETOCHORE Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2 biological_process molecular_function spindle pole body|kinetochore
YEL018W YEL018W EAF5 hom Verified 1.15846482434955 0.123337199198579 no 625 0.138653222274236 498 NA FT CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS HISTONE ACETYLTRANSFERASE Esa1p-associated factor, non-essential subunit of the NuA4 acetyltransferase complex DNA repair molecular_function nucleus|NuA4 histone acetyltransferase complex
YNL281W YNL281W HCH1 hom Verified 1.15778525985258 0.123475840053818 no 626 0.0894597400038752 345 NA FT NUCLEOTIDE METABOLISM NUCLEUS Heat shock protein regulator; binds to Hsp90p and may stimulate ATPase activity; originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation; GFP-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress protein folding|response to stress ATPase activator activity|chaperone binding nucleus|cytoplasm
YIL114C YIL114C POR2 hom Verified 1.15759992126689 0.123513670708537 no 627 0.121350859667098 392 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Putative mitochondrial porin (voltage-dependent anion channel); not required for mitochondrial membrane permeability or mitochondrial osmotic stability; POR2 has a paralog, POR1, that arose from the whole genome duplication DNA transport|ion transport|cell redox homeostasis voltage-gated anion channel activity mitochondrial outer membrane|mitochondrion|integral to membrane
YBR047W_p YBR047W FMP23 hom Uncharacterized 1.15630985314789 0.123777219755236 no 628 0.118020166289833 441 NA FT MITOCHONDRION Putative protein of unknown function; proposed to be involved in iron or copper homeostasis; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YML060W YML060W OGG1 hom Verified 1.15486489876196 0.124072877771952 no 629 0.120504403132047 432 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA, contributes to UVA resistance DNA repair|base-excision repair, AP site formation oxidized purine nucleobase lesion DNA N-glycosylase activity mitochondrion
YFR046C YFR046C CNN1 hom Verified 1.15165713554101 0.124730996451275 no 630 0.106882382983138 421 NA FT CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME KINETOCHORE Kinetochore protein; associated with the essential kinetochore proteins Nnf1p and Spc24p; phosphorylated by Clb5-Cdk1, Mps1p, Ipl1p and to a lesser extent by Clb2-Cdk1; localizes to the lower region of the Ndc80 complex during anaphase and regulates KMN activity by inhibiting the Mtw1 and Spc105 complexes from binding to the Ndc80 complex; similar to metazoan CENP-T chromosome segregation molecular_function nucleus|kinetochore
YFR012W YFR012W DCV1 hom Verified 1.15067317247281 0.124933358666851 no 631 0.104930992993104 398 NA Protein of unknown function; deletion mutant shows strong genetic interaction with cdc28-as1 mutant in the presence of 1-NM-PP1; DCV1 has a paralog, YOL019W, that arose from the whole genome duplication biological_process molecular_function integral to membrane
YPL030W YPL030W TRM44 hom Verified 1.15060503486822 0.124947380358733 no 632 0.104417129447221 396 NA FT RNA PROCESSING tRNA(Ser) Um(44) 2'-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS(CGA) and tS(UGA); conserved among metazoans and fungi but there does not appear to be a homolog in plants; TRM44 is a non-essential gene tRNA methylation tRNA (uracil) methyltransferase activity cytoplasm
YKL217W YKL217W JEN1 hom Verified 1.15049946650863 0.124969106906831 no 633 0.120860657672653 452 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION|PLASMA MEMBRANE Monocarboxylate/proton symporter of the plasma membrane; transport activity is dependent on the pH gradient across the membrane; mediates high-affinity uptake of carbon sources lactate, pyuvate, and acetate, and also of the micronutrient selenite, whose structure mimics that of monocarboxylates; expression and localization are tightly regulated, with transcription repression, mRNA degradation, and protein endocytosis and degradation all occurring in the presence of glucose plasma membrane lactate transport|plasma membrane selenite transport|plasma membrane pyruvate transport selenite:hydrogen symporter activity|secondary active monocarboxylate transmembrane transporter activity mitochondrion|integral to membrane|plasma membrane
YGL054C YGL054C ERV14 hom Verified 1.15011576549566 0.125048096909845 no 634 0.257015810019941 916 NA FF|FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|SIGNALING|CELL DIVISION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS COPII-coated vesicle protein; involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon; ERV14 has a paralog, ERV15, that arose from the whole genome duplication ascospore formation|ER to Golgi vesicle-mediated transport|axial cellular bud site selection molecular_function integral to membrane|ER to Golgi transport vesicle|endoplasmic reticulum membrane
YLR432W YLR432W IMD3 hom Verified 1.14997264398313 0.125077569321807 no 635 0.155497990982937 549 NA FT OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed GTP biosynthetic process IMP dehydrogenase activity plasma membrane|cytoplasm
YDR378C YDR378C LSM6 hom Verified 1.14822570080433 0.125437701036302 no 636 0.139222302145853 557 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA nuclear-transcribed mRNA catabolic process|mRNA splicing, via spliceosome|maturation of SSU-rRNA RNA binding U6 snRNP|nucleolus|small nucleolar ribonucleoprotein complex|U4/U6 x U5 tri-snRNP complex|cytoplasmic mRNA processing body
YHR182W YHR182W YHR182W hom Verified 1.14805401320554 0.125473133393252 no 637 0.145972029682021 434 NA FT SIGNALING Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm; relocalizes from bud neck to cytoplasm upon DNA replication stress biological_process molecular_function cytoplasm
YGR177C YGR177C ATF2 hom Verified 1.147617568251 0.125563237003123 no 638 0.106932545075509 378 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Alcohol acetyltransferase, may play a role in steroid detoxification; forms volatile esters during fermentation, which is important for brewing and winemaking steroid metabolic process|response to toxin|Unknown|sterol acetylation alcohol O-acetyltransferase activity integral to endoplasmic reticulum membrane|endoplasmic reticulum|cytoplasm
YOR144C YOR144C ELG1 hom Verified 1.14758823164093 0.125569295135025 no 639 0.118668564168448 461 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS|MITOCHONDRION|CHROMOSOME Subunit of an alternative replication factor C complex important for DNA replication and genome integrity; suppresses spontaneous DNA damage; involved in homologous recombination-mediated repair and telomere homeostasis; required for PCNA (Pol30p) unloading during DNA replication negative regulation of DNA recombination|negative regulation of transposition, RNA-mediated|telomere maintenance|double-strand break repair via homologous recombination|DNA-dependent DNA replication|mitotic sister chromatid cohesion chromatin binding Elg1 RFC-like complex|mitochondrion|nucleus|cytoplasm
YHR114W YHR114W BZZ1 hom Verified 1.14716315882378 0.125657097326913 no 640 0.101202156593635 406 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON SH3 domain protein implicated in the regulation of actin polymerization, able to recruit actin polymerization machinery through its SH3 domains, colocalizes with cortical actin patches and Las17p, interacts with type I myosins response to salt stress|actin filament organization|endocytosis molecular_function mating projection tip|cytoplasm|actin cortical patch
YEL053C YEL053C MAK10 hom Verified 1.14701856725808 0.125686973632846 no 641 0.118601730405212 477 NA Non-catalytic subunit of N-terminal acetyltransferase of the NatC type, required for replication of dsRNA virus; expression is glucose-repressible N-terminal protein amino acid acetylation peptide alpha-N-acetyltransferase activity NatC complex|cytoplasm
YGL141W YGL141W HUL5 hom Verified 1.14600836735766 0.125895844964898 no 642 0.131003228199351 450 NA FT PROTEOLYSIS NUCLEUS Multiubiquitin chain assembly factor (E4); proteasome processivity factor that elongates polyUb chains on substrates, opposing Ubp6p, a branched polyubiquitin protease; required for retrograde transport of misfolded proteins during ERAD ER-associated protein catabolic process|protein polyubiquitination ubiquitin-ubiquitin ligase activity proteasome complex|nucleus|cytoplasm
YOR226C YOR226C ISU2 hom Verified 1.14495466549596 0.12611396866956 no 643 0.117835283916121 487 NA FT RNA PROCESSING|ION HOMEOSTASIS|ION HOMEOSTASIS|COFACTOR METABOLISM MITOCHONDRION Protein required for synthesis of iron-sulfur proteins; localized to the mitochondrial matrix; performs a scaffolding function in mitochondria during Fe/S cluster assembly; involved in Fe-S cluster assembly for both mitochondrial and cytosolic proteins; isu1 isu2 double mutant is inviable; protein abundance increases in response to DNA replication stress; evolutionarily conserved cellular iron ion homeostasis|iron-sulfur cluster assembly|tRNA wobble uridine modification molecular_function mitochondrial matrix
YKL032C YKL032C IXR1 hom Verified 1.14439534914805 0.126229858066926 no 644 0.159438153139329 580 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Protein that binds DNA containing intrastrand cross-links formed by cisplatin, contains two HMG (high mobility group box) domains, which confer the ability to bend cisplatin-modified DNA; mediates aerobic transcriptional repression of COX5b DNA repair|cellular response to hypoxia|negative regulation of transcription from RNA polymerase II promoter damaged DNA binding|sequence-specific DNA binding nuclear chromatin
YML086C YML086C ALO1 hom Verified 1.14288803577498 0.12654254030391 no 645 0.101592792737794 384 NA FT OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS MITOCHONDRION D-Arabinono-1,4-lactone oxidase, catalyzes the final step in biosynthesis of dehydro-D-arabinono-1,4-lactone, which is protective against oxidative stress cellular response to oxidative stress|dehydro-D-arabinono-1,4-lactone biosynthetic process D-arabinono-1,4-lactone oxidase activity mitochondrial outer membrane|mitochondrion|integral to mitochondrial outer membrane
YCR065W YCR065W HCM1 hom Verified 1.14103839501896 0.126926972807714 no 646 0.128632176779812 523 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|RESPONSE TO OXIDATIVE STRESS NUCLEUS|CHROMOSOME Forkhead transcription factor that drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere maintenance role positive regulation of transcription involved in S-phase of mitotic cell cycle|cellular response to oxidative stress|mitochondrion organization|spindle pole body organization|positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding nuclear chromatin|nucleus|cytoplasm
YKL138C YKL138C MRPL31 hom Verified 1.13967031983554 0.12721183841489 no 647 0.150158686510011 545 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrial large ribosomal subunit
YMR071C YMR071C TVP18 hom Verified 1.13961156719787 0.12722408205681 no 648 0.162907012244337 590 NA FF|FT VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments vesicle-mediated transport molecular_function integral to membrane|integral to Golgi membrane|clathrin-coated vesicle
YMR031C YMR031C EIS1 hom Verified 1.13821221363915 0.127515939947815 no 649 0.137452676757136 468 NA FT PROTEIN COMPLEX ORG/BIOGENESIS MITOCHONDRION|PLASMA MEMBRANE Component of the eisosome required for proper eisosome assembly; similarity to Ykl050cp and Uso1p; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress eisosome assembly molecular_function eisosome|mitochondrion|membrane raft|cytoplasm
YHR029C YHR029C YHI9 hom Verified 1.13157663407043 0.128906234082825 no 650 0.141927691077242 495 NA FT SIGNALING Protein of unknown function; null mutant is defective in unfolded protein response; possibly involved in a membrane regulation metabolic pathway; member of the PhzF superfamily, though most likely not involved in phenazine production endoplasmic reticulum unfolded protein response molecular_function cellular_component
YLR322W_d YLR322W VPS65 hom Dubious 1.1300118479684 0.129235616060969 no 651 0.146436267245038 551 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 75% of ORF overlaps the verified gene SFH1; deletion causes a vacuolar protein sorting defect and blocks anaerobic growth Unknown Unknown Unknown
YHR199C YHR199C AIM46 hom Verified 1.1297026217776 0.129300776062058 no 652 0.190042521270905 634 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss biological_process molecular_function mitochondrion
YGR026W_p YGR026W YGR026W hom Uncharacterized 1.12880740733123 0.129489543604989 no 653 0.134314279046804 456 NA FT PLASMA MEMBRANE Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery biological_process molecular_function integral to membrane
YKL076C_d YKL076C PSY1 hom Dubious 1.12746451657552 0.129773067374494 no 654 0.134181986941338 498 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C Unknown Unknown Unknown
YKL011C YKL011C CCE1 hom Verified 1.12707883603514 0.12985457529206 no 655 0.139747518127567 522 NA FT MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial cruciform cutting endonuclease, cleaves Holliday junctions formed during recombination of mitochondrial DNA mitochondrial genome maintenance endodeoxyribonuclease activity mitochondrial inner membrane
YGR126W_p YGR126W YGR126W hom Uncharacterized 1.1264195505076 0.129993987673518 no 656 0.116127041440543 464 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS biological_process molecular_function nucleus|cytoplasm
YNL180C YNL180C RHO5 hom Verified 1.12416430131498 0.130471665411358 no 657 0.137991101811878 484 NA FT SIGNALING NUCLEUS|PLASMA MEMBRANE Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity Rho protein signal transduction GTPase activity endomembrane system|fungal-type vacuole membrane|plasma membrane|nucleus|cytoplasm
YBR279W YBR279W PAF1 hom Verified 1.12294039756659 0.130731404433325 no 658 0.19784083489521 706 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION|GENE SILENCING NUCLEUS|CHROMOSOME RNA POL II, HOLOENZYME Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cell cycle-regulated genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; homolog of human PD2/hPAF1 negative regulation of DNA recombination|mRNA 3'-end processing|snoRNA transcription from an RNA polymerase II promoter|regulation of transcription by chromatin organization|transcription from RNA polymerase I promoter|regulation of transcription-coupled nucleotide-excision repair|rRNA processing|transcription elongation from RNA polymerase I promoter|regulation of chromatin silencing at telomere|regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of histone H3-K4 methylation|negative regulation of transcription from RNA polymerase II promoter|global genome nucleotide-excision repair|chromatin silencing at rDNA|Unknown|snoRNA 3'-end processing|transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|chromatin binding|TFIIF-class binding transcription factor activity|RNA polymerase II core binding|RNA polymerase II transcription factor binding transcription factor activity transcriptionally active chromatin|nucleus|Cdc73/Paf1 complex
YGL154C YGL154C LYS5 hom Verified 1.12224015606753 0.13088017157583 no 659 0.107203275535695 381 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Phosphopantetheinyl transferase involved in lysine biosynthesis; converts inactive apo-form of Lys2p (alpha-aminoadipate reductase) into catalytically active holo-form by posttranslational addition of phosphopantetheine lysine biosynthetic process via aminoadipic acid|protein-cofactor linkage holo-[acyl-carrier-protein] synthase activity cytoplasm
YML123C YML123C PHO84 hom Verified 1.12211275128127 0.130907251449462 no 660 0.175827150378898 618 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p; cells overexpressing Pho84p accumulate heavy metals but do not develop symptoms of metal toxicity phosphate ion transport|manganese ion transport|polyphosphate metabolic process manganese ion transmembrane transporter activity|inorganic phosphate transmembrane transporter activity integral to membrane|integral to plasma membrane
YPL257W_p YPL257W YPL257W hom Uncharacterized 1.11846043730092 0.131685197201897 no 661 0.135184813948082 484 NA FT CELL CYCLE Putative protein of unknown function; homozygous diploid deletion strain exhibits low budding index; physically interacts with Hsp82p; YPL257W is not an essential gene biological_process molecular_function integral to membrane
YPL254W YPL254W HFI1 hom Verified 1.11638583906556 0.132128506213019 no 662 0.149443758749145 535 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS HISTONE ACETYLTRANSFERASE Adaptor protein required for structural integrity of the SAGA complex, a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions histone acetylation|chromatin modification|transcription from RNA polymerase II promoter transcription coactivator activity|transcription cofactor activity SLIK (SAGA-like) complex|Ada2/Gcn5/Ada3 transcription activator complex|SAGA complex
YJR003C_p YJR003C YJR003C hom Uncharacterized 1.11583166339713 0.132247098781611 no 663 0.133972256391698 474 NA FT MITOCHONDRION Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; predicted to be involved in ribosome biogenesis biological_process molecular_function mitochondrion
YDR293C YDR293C SSD1 hom Verified 1.11428712740019 0.132578013793905 no 664 0.268410369951205 974 NA FF|FT CELL CYCLE|TRANSLATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION|RNA LOCALIZATION NUCLEUS|SITE OF POLARIZED GROWTH Translational repressor with a role in polar growth and wall integrity; regulated by Cbk1p phosphorylation to effect bud-specific translational control and localization of specific mRNAs; interacts with TOR pathway components; contains a functional N-terminal nuclear localization sequence and nucleocytoplasmic shuttling appears to be critical to Ssd1p function regulation of fungal-type cell wall organization|negative regulation of translation|intracellular mRNA localization mRNA binding|mRNA 5'-UTR binding|translation repressor activity, nucleic acid binding nucleus|cellular bud|cytoplasmic stress granule|cytoplasmic mRNA processing body|cellular bud neck|cytoplasm
YBR203W YBR203W COS111 hom Verified 1.108672045729 0.133785842721936 no 665 0.170626420287921 577 NA FT SIGNALING MITOCHONDRION Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies signal transduction molecular_function mitochondrion
YOR072W_d YOR072W YOR072W hom Dubious 1.10627073176106 0.134304677992969 no 666 0.201674255127524 728 NA FF Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive Unknown Unknown Unknown
YBL006C YBL006C LDB7 hom Verified 1.10623818128491 0.134311720428049 no 667 0.216412834175967 769 NA FF|FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|CELL WALL ORG/BIOGENESIS NUCLEUS RSC COMPLEX Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions ATP-dependent chromatin remodeling|cell wall mannoprotein biosynthetic process|nucleosome disassembly|transcription elongation from RNA polymerase II promoter DNA translocase activity RSC complex
YNL059C YNL059C ARP5 hom Verified 1.10600950842988 0.134361201929352 no 668 0.144660062993592 509 NA FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes nucleosome mobilization|chromatin remodeling ATP-dependent 3'-5' DNA helicase activity nucleus|Ino80 complex
YPR020W YPR020W ATP20 hom Verified 1.10570479689324 0.134427156553599 no 669 0.13107274993407 503 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS MITOCHONDRION Subunit g of the mitochondrial F1F0 ATP synthase; reversibly phosphorylated on two residues; unphosphorylated form is required for dimerization of the ATP synthase complex protein oligomerization|cristae formation|protein complex assembly|ATP synthesis coupled proton transport structural molecule activity|proton-transporting ATPase activity, rotational mechanism mitochondrion|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
YAL037W_p YAL037W YAL037W hom Uncharacterized 1.10439903959011 0.134710038616483 no 670 0.144516236365411 527 NA Putative protein of unknown function; YAL037W has a paralog, YOR342C, that arose from the whole genome duplication biological_process molecular_function cellular_component
YNL333W YNL333W SNZ2 hom Verified 1.10415716848553 0.134762482901083 no 671 0.134302320732375 477 NA FT COFACTOR METABOLISM Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO2; interacts with Thi11p pyridoxine metabolic process|thiamine biosynthetic process protein binding cellular_component
YJL030W YJL030W MAD2 hom Verified 1.10226688649686 0.135172830419917 no 672 0.125078998529738 472 NA FT CELL CYCLE|CELL DIVISION ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME NUCLEAR PORE|KINETOCHORE Component of the spindle-assembly checkpoint complex; delays the onset of anaphase in cells with defects in mitotic spindle assembly; forms a complex with Mad1p; regulates APC/C activity during prometaphase and metaphase of meiosis I chromosome decondensation|mitotic cell cycle spindle assembly checkpoint|mitotic cell cycle G2/M transition decatenation checkpoint molecular_function mitotic checkpoint complex|condensed nuclear chromosome kinetochore|nuclear pore
YLR039C YLR039C RIC1 hom Verified 1.10170676389979 0.13529458771409 no 673 0.242259307686902 777 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes intracellular protein transport|retrograde transport, endosome to Golgi guanyl-nucleotide exchange factor activity nucleus|Ric1p-Rgp1p complex|Golgi membrane|guanyl-nucleotide exchange factor complex
YAL016C-B_d YAL016C-B YAL016C-B hom Dubious 1.09962948962314 0.135746793887446 no 674 0.115765457374216 446 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YHR008C YHR008C SOD2 hom Verified 1.09842270873671 0.136009975402389 no 675 0.21774940118063 693 NA FF|FT OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS MITOCHONDRION Mitochondrial manganese superoxide dismutase, protects cells against oxygen toxicity; phosphorylated reactive oxygen species metabolic process|age-dependent response to oxidative stress involved in chronological cell aging|replicative cell aging|age-dependent response to reactive oxygen species involved in chronological cell aging superoxide dismutase activity mitochondrion|mitochondrial matrix
YGL005C YGL005C COG7 hom Verified 1.09692724269451 0.136336599343162 no 676 0.289719351242142 1007 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|MITOCHONDRION|GOLGI APPARATUS Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments intra-Golgi vesicle-mediated transport|CVT pathway molecular_function mitochondrion|Golgi transport complex
YNL283C YNL283C WSC2 hom Verified 1.09645705196747 0.136439404246553 no 677 0.16902881416505 631 NA FF|FT SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity and recovery from heat shock; secretory pathway Wsc2p is required for the arrest of secretion response fungal-type cell wall organization|response to heat|Rho protein signal transduction transmembrane signaling receptor activity site of polarized growth|cellular bud|mating projection tip|cytoplasm
YDR525W-A YDR525W-A SNA2 hom Verified 1.09604335119647 0.136529901739959 no 678 0.136054959905469 525 NA Protein of unknown function, has similarity to Pmp3p, which is involved in cation transport; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern biological_process molecular_function fungal-type vacuole membrane|integral to membrane|cytoplasm
YML084W_d YML084W YML084W hom Dubious 1.09317276664143 0.137158975867282 no 679 0.110659752611609 397 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR479C YDR479C PEX29 hom Verified 1.09152836267209 0.137520229349736 no 680 0.144705515349714 496 NA FT PEROXISOME ORGANIZATION Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress peroxisome organization molecular_function integral to membrane|peroxisomal membrane
YKR088C YKR088C TVP38 hom Verified 1.09078601487818 0.137683525810112 no 681 0.138181410333943 511 NA FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|CYTOSKELETON ORGANIZATION ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; required for asymmetric localization of Kar9p during mitosis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern vesicle-mediated transport|mitotic spindle elongation molecular_function integral to membrane|integral to Golgi membrane|cytoplasm
YBL060W YBL060W YEL1 hom Verified 1.08568949715551 0.138808194468554 no 682 0.14973009259432 531 NA FT PROTEIN LOCALIZATION|LIPID METABOLISM|SIGNALING SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Guanine nucleotide exchange factor specific for Arf3p; localized to the bud neck and tip; required for localization of Arf3p to the bud neck and tip positive regulation of phosphatidylinositol biosynthetic process|protein localization|actin cortical patch localization ARF guanyl-nucleotide exchange factor activity cellular bud neck|cellular bud tip|cytoplasm
YGR285C YGR285C ZUO1 hom Verified 1.08191833254076 0.139644409049961 no 683 0.140747626143676 532 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION NUCLEUS|MITOCHONDRION RIBOSOME Ribosome-associated chaperone, functions in ribosome biogenesis and, in partnership with Ssz1p and SSb1/2, as a chaperone for nascent polypeptide chains; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p protein folding|ribosomal subunit export from nucleus|rRNA processing|regulation of translational fidelity unfolded protein binding mitochondrion|ribosome|nucleolus|polysome|cytoplasm
YGL129C YGL129C RSM23 hom Verified 1.08152712538995 0.139731350652131 no 684 0.152206028303026 568 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit, has similarity to mammalian apoptosis mediator proteins; null mutation prevents induction of apoptosis by overproduction of metacaspase Mca1p mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YMR169C YMR169C ALD3 hom Verified 1.08152085981598 0.139732743408236 no 685 0.139804778149471 518 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS Cytoplasmic aldehyde dehydrogenase, involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose beta-alanine biosynthetic process|polyamine catabolic process aldehyde dehydrogenase (NAD) activity cytoplasm
YLR038C YLR038C COX12 hom Verified 1.08121502961797 0.139800736981574 no 686 0.141212030415822 507 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Subunit VIb of cytochrome c oxidase; cytochrome c oxidase is also known as respiratory Complex IV and is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated; easily released from the intermembrane space, suggesting a loose association with Complex IV mitochondrial respiratory chain complex IV assembly cytochrome-c oxidase activity mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YDL047W YDL047W SIT4 hom Verified 1.07857189728847 0.140389307384232 no 687 0.142581192308533 521 NA FT CELL CYCLE|RNA PROCESSING|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CYTOSKELETON ORGANIZATION|RESPONSE TO OXIDATIVE STRESS NUCLEUS Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization intracellular protein kinase cascade|replicative cell aging|G1/S transition of mitotic cell cycle|actin cytoskeleton organization|DNA repair|cellular response to oxidative stress|fungal-type cell wall organization|TOR signaling cascade|dephosphorylation|tRNA wobble uridine modification protein serine/threonine phosphatase activity nucleus|cytoplasm
YHR100C YHR100C GEP4 hom Verified 1.07827771548187 0.140454919436449 no 688 0.210358541443056 718 NA FF|FT LIPID METABOLISM|CARBOHYDRATE METABOLISM MITOCHONDRION Mitochondrial phosphatidylglycerophosphatase (PGP phosphatase), dephosphorylates phosphatidylglycerolphosphate to generate phosphatidylglycerol, an essential step during cardiolipin biosynthesis; null mutant is sensitive to tunicamycin, DTT cardiolipin biosynthetic process|phosphorylated carbohydrate dephosphorylation phosphatidylglycerophosphatase activity mitochondrion|mitochondrial matrix
YJL022W_d YJL022W YJL022W hom Dubious 1.07824488052737 0.140462243984015 no 689 0.148977713282258 484 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130 Unknown Unknown Unknown
YMR201C YMR201C RAD14 hom Verified 1.07488456683587 0.141213206207308 no 690 0.14911163085725 532 NA FT RESPONSE TO DNA DAMAGE NUCLEUS Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein nucleotide-excision repair, DNA damage recognition damaged DNA binding|zinc ion binding nucleotide-excision repair factor 1 complex|nucleus
YBL038W YBL038W MRPL16 hom Verified 1.07471583160029 0.141250986762823 no 691 0.168074203414021 592 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome|peptidyltransferase activity mitochondrion|mitochondrial large ribosomal subunit
YJR033C YJR033C RAV1 hom Verified 1.07380379819005 0.14145531363388 no 692 0.172693927288269 648 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate early endosome to late endosome transport|vacuolar acidification|regulation of protein complex assembly molecular_function RAVE complex|cytoplasm|extrinsic to membrane
YBR288C YBR288C APM3 hom Verified 1.07283884700695 0.141671713873554 no 693 0.16596989031268 593 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway Golgi to vacuole transport|vesicle-mediated transport molecular_function AP-3 adaptor complex
YDR175C YDR175C RSM24 hom Verified 1.07129747768677 0.142017846798871 no 694 0.153987690754439 528 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YOR150W YOR150W MRPL23 hom Verified 1.07105126687252 0.142073189364623 no 695 0.172336276540968 600 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YLL040C YLL040C VPS13 hom Verified 1.07086986619306 0.142113973431309 no 696 0.139783902200641 504 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT MITOCHONDRION|GOLGI APPARATUS Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; involved in sporulation, vacuolar protein sorting, prospore membrane formation and protein-Golgi retention; homologous to human CHAC and COH1 which are involved in chorea acanthocytosis and Cohen syndrome, respectively protein retention in Golgi apparatus|late endosome to vacuole transport|protein targeting to vacuole|ascospore-type prospore membrane assembly molecular_function endosome|mitochondrion|prospore membrane|extrinsic to membrane
YDR393W YDR393W SHE9 hom Verified 1.07028948934298 0.142244511993615 no 697 0.161188054546225 589 NA FT MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial inner membrane protein required for normal mitochondrial morphology, may be involved in fission of the inner membrane; forms a homo-oligomeric complex mitochondrion organization|inner mitochondrial membrane organization molecular_function mitochondrial inner membrane
YPR173C YPR173C VPS4 hom Verified 1.06903555296552 0.14252682474557 no 698 0.178751435332388 621 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|LIPID METABOLISM|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT ENDOPLASMIC RETICULUM AAA-ATPase involved in multivesicular body (MVB) protein sorting, ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism late endosome to vacuole transport via multivesicular body sorting pathway|protein retention in Golgi apparatus|intralumenal vesicle formation|protein homooligomerization|sterol metabolic process|late endosome to vacuole transport ATPase activity|protein homodimerization activity|ATP binding endosome|endoplasmic reticulum|membrane|cytoplasm
YBL087C YBL087C RPL23A hom Verified 1.06787090379751 0.142789374472885 no 699 0.149706216781424 500 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L23A; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23A has a paralog, RPL23B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YDL044C YDL044C MTF2 hom Verified 1.06777017465643 0.142812097441765 no 700 0.159659906866283 588 NA FT RNA PROCESSING|TRANSLATION MITOCHONDRION Mitochondrial matrix protein that interacts with an N-terminal region of mitochondrial RNA polymerase (Rpo41p) and couples RNA processing and translation to transcription cytoplasmic translation|mRNA processing RNA binding mitochondrion
YEL061C YEL061C CIN8 hom Verified 1.06751367902103 0.142869970008827 no 701 0.156010091277974 601 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION NUCLEUS|MITOCHONDRION|CHROMOSOME|CYTOSKELETON KINETOCHORE Kinesin motor protein involved in mitotic spindle assembly and chromosome segregation mitotic anaphase B|microtubule depolymerization|spindle pole body separation|mitotic spindle organization in nucleus|mitotic sister chromatid segregation plus-end-directed microtubule motor activity|minus-end-directed microtubule motor activity spindle microtubule|kinesin complex|mitochondrion|condensed nuclear chromosome kinetochore|kinetochore microtubule|astral microtubule
YFR045W_p YFR045W YFR045W hom Uncharacterized 1.06732726740161 0.142912039612207 no 702 0.122122334896362 435 NA FT MITOCHONDRION Putative mitochondrial transport protein; null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white transport transporter activity integral to membrane|mitochondrial inner membrane
YLR422W_p YLR422W YLR422W hom Uncharacterized 1.06640943702135 0.143119298781096 no 703 0.154946690000036 575 NA Protein of unknown function with similarity to human DOCK proteins (guanine nucleotide exchange factors); interacts with Ino4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, YLR422W is not an essential protein biological_process molecular_function cytoplasm
YBL103C YBL103C RTG3 hom Verified 1.06603707320171 0.14320344170591 no 704 0.134748556361233 470 NA FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|SIGNALING NUCLEUS Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways mitochondrion degradation|cellular response to oleic acid|mitochondria-nucleus signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription factor import into nucleus RNA polymerase II transcription factor binding|sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity nucleus|cytoplasm
YGR196C YGR196C FYV8 hom Verified 1.06550779796069 0.143323099341348 no 705 0.143282148433389 516 NA Protein of unknown function, required for survival upon exposure to K1 killer toxin biological_process molecular_function cytoplasm
YGL181W YGL181W GTS1 hom Verified 1.06509759479141 0.143415883797005 no 706 0.146814462784772 467 NA FT VESICLE-MEDIATED TRANSPORT|TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM|MEMBRANE ORGANIZATION|SIGNALING|NUCLEOTIDE METABOLISM NUCLEUS|CYTOSKELETON Protein involved in Arf3p regulation and in transcription regulation; localizes to the nucleus and to endocytic patches; contains an N-terminal Zn-finger and ArfGAP homology domain, a C-terminal glutamine-rich region, and a UBA (ubiquitin associated) domain; gts1 mutations affect budding, cell size, heat tolerance, sporulation, life span, ultradian rhythms, endocytosis; expression oscillates in a pattern similar to metabolic oscillations endocytosis|ultradian rhythm|regulation of transcription from RNA polymerase II promoter|negative regulation of phosphatidylinositol biosynthetic process|positive regulation of transcription from RNA polymerase II promoter ARF GTPase activator activity|repressing transcription factor binding|transcription factor binding transcription factor activity nucleus|cytoplasm|actin cortical patch
YPR051W YPR051W MAK3 hom Verified 1.06403543608998 0.143656323457745 no 707 0.182610719601409 657 NA FT NUCLEUS Catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus N-terminal protein amino acid acetylation peptide alpha-N-acetyltransferase activity NatC complex
YKR087C YKR087C OMA1 hom Verified 1.06289976348039 0.143913705150238 no 708 0.142179287060084 529 NA FT PROTEOLYSIS MITOCHONDRION Metalloendopeptidase of the mitochondrial inner membrane; involved in turnover of membrane-embedded proteins; mediates degradation of Cox1p in coa2 mutant cells; member of a family of predicted membrane-bound metallopeptidases in prokaryotes and higher eukaryotes misfolded or incompletely synthesized protein catabolic process metalloendopeptidase activity mitochondrion|mitochondrial inner membrane
YOR196C YOR196C LIP5 hom Verified 1.06186855894318 0.144147680150006 no 709 0.164671006912998 624 NA FT KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM MITOCHONDRION Protein involved in biosynthesis of the coenzyme lipoic acid, has similarity to E. coli lipoic acid synthase protein lipoylation lipoate synthase activity mitochondrion
YDR032C YDR032C PST2 hom Verified 1.06183474123597 0.144155357554632 no 710 0.128928311987407 497 NA FT OXIDATION-REDUCTION PROCESS MITOCHONDRION Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication biological_process molecular_function mitochondrion|membrane raft|plasma membrane|cytoplasm
YBR300C_d YBR300C YBR300C hom Dubious 1.06083063585329 0.144383438409293 no 711 0.160389720643708 563 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR301W; YBR300C is not an essential gene Unknown Unknown Unknown
YGL049C YGL049C TIF4632 hom Verified 1.06025816066303 0.144513583987575 no 712 0.11918500908091 442 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION RIBOSOME Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); TIF4632 has a paralog, TIF4631, that arose from the whole genome duplication translational initiation|stress granule assembly translation initiation factor binding|mRNA binding|translation initiation factor activity eukaryotic translation initiation factor 4F complex|cytoplasmic stress granule
YLR111W_d YLR111W YLR111W hom Dubious 1.05897448959512 0.144805698932198 no 713 0.167074620922978 689 NA FF Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPR057W YPR057W BRR1 hom Verified 1.05808818135507 0.145007621029781 no 714 0.109617568193834 439 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING NUCLEUS snRNP protein component of spliceosomal snRNPs, required for pre-mRNA splicing and snRNP biogenesis; in null mutant newly-synthesized snRNAs are destabilized and 3'-end processing is slowed spliceosomal complex assembly RNA binding small nuclear ribonucleoprotein complex
YJL193W_p YJL193W YJL193W hom Uncharacterized 1.05477125724881 0.145764976561906 no 715 0.141159080046057 525 NA Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect biological_process molecular_function integral to membrane
YGR219W_d YGR219W YGR219W hom Dubious 1.05298163294372 0.146174705040169 no 716 0.170868176022075 535 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRPL9/YGR220C Unknown Unknown Unknown
YNR060W YNR060W FRE4 hom Verified 1.05131958111528 0.146555918388771 no 717 0.139597034510808 531 NA FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY PLASMA MEMBRANE Ferric reductase, reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels siderophore transport ferric-chelate reductase activity integral to membrane|plasma membrane
YGL078C YGL078C DBP3 hom Verified 1.04618539376555 0.147737722596409 no 718 0.159521236019592 561 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS RNA-Dependent ATPase, member of DExD/H-box family; involved in cleavage of site A3 within the ITS1 spacer during rRNA processing; not essential for growth, but deletion causes severe slow-growth phenotype endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) RNA-dependent ATPase activity nucleolus|preribosome, large subunit precursor
YBR105C YBR105C VID24 hom Verified 1.04442419591185 0.148144586962453 no 719 0.160474456885434 568 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|KETONE METABOLISM|MEMBRANE ORGANIZATION|CARBOHYDRATE METABOLISM|PROTEOLYSIS|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM GID Complex regulatory subunit; binds GID Complex in response to glucose through interactions with complex member Vid28p; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; promotes proteasome-dependent catabolite degradation of FBPase; peripheral membrane protein located at Vid (vacuole import and degradation) vesicles negative regulation of gluconeogenesis|vesicle fusion with vacuole|vacuolar protein catabolic process|proteasomal ubiquitin-dependent protein catabolic process|vesicle-mediated transport|protein targeting to vacuole molecular_function cytoplasmic membrane-bounded vesicle|GID complex|extrinsic to membrane
YAR050W YAR050W FLO1 hom Verified 1.04396026333675 0.148251887320958 no 720 0.168917461112685 536 NA FT PLASMA MEMBRANE Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p cellular response to stress|flocculation via cell wall protein-carbohydrate interaction|flocculation mannose binding fungal-type cell wall
YLR240W YLR240W VPS34 hom Verified 1.04311642068299 0.148447188208395 no 721 0.159233916420844 615 NA FT PROTEIN LOCALIZATION|LIPID METABOLISM|SIGNALING|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION GOLGI APPARATUS Phosphatidylinositol (PI) 3-kinase that synthesizes PI-3-phosphate; forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting; activated by the GTP-bound form of Gpa1p; a fraction is localized, with Vps15p, to nuclear pores at nucleus-vacuole junctions and may facilitate transcription elongation for genes positioned at the nuclear periphery peroxisome degradation|phosphatidylinositol phosphorylation|protein phosphorylation 1-phosphatidylinositol-3-kinase activity|protein kinase activity endosome|fungal-type vacuole membrane|phosphatidylinositol 3-kinase complex I|phosphatidylinositol 3-kinase complex II|peroxisome|pre-autophagosomal structure
YJL037W YJL037W IRC18 hom Verified 1.04240962795382 0.148610902299514 no 722 0.153905819998074 592 NA Putative protein of unknown function; expression induced in respiratory-deficient cells and in carbon-limited chemostat cultures; similar to adjacent ORF, YJL038C; null mutant displays increased levels of spontaneous Rad52p foci biological_process molecular_function cellular_component
YER059W YER059W PCL6 hom Verified 1.04196096875644 0.14871488764112 no 723 0.130800861772335 483 NA FT CELL CYCLE|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Pho85p cyclin of the Pho80p subfamily; forms the major Glc8p kinase together with Pcl7p and Pho85p; involved in the control of glycogen storage by Pho85p; stabilized by Elongin C binding regulation of glycogen catabolic process|regulation of glycogen biosynthetic process cyclin-dependent protein kinase regulator activity cyclin-dependent protein kinase holoenzyme complex
YMR225C YMR225C MRPL44 hom Verified 1.04001451406341 0.149166578782971 no 724 0.145738003990466 542 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YER121W_p YER121W YER121W hom Uncharacterized 1.03985859258662 0.14920280126498 no 725 0.170808739033858 564 NA Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy biological_process molecular_function cellular_component
YKR096W YKR096W ESL2 hom Verified 1.03932657009578 0.149326440862825 no 726 0.156842135739694 519 NA FT NUCLEUS Protein of unknown function that interacts with Pex14p; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; predicted to contain a PINc domain biological_process molecular_function ribosome|nucleus|cytoplasm
YDR541C_p YDR541C YDR541C hom Uncharacterized 1.03678230279694 0.149918662510955 no 727 0.156406570428682 560 NA FT OXIDATION-REDUCTION PROCESS Putative dihydrokaempferol 4-reductase biological_process carbonyl reductase (NADPH) activity cellular_component
YBL065W_d YBL065W YBL065W hom Dubious 1.03643063272931 0.150000642764749 no 728 0.163444027269423 529 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene Unknown Unknown Unknown
YHR138C YHR138C YHR138C hom Verified 1.03512263715273 0.150305821005993 no 729 0.148191040616663 475 NA FT MEMBRANE ORGANIZATION Protein of unknown function; similar to Pbi2p; double null mutant lacking Pbi2p and Yhr138cp exhibits highly fragmented vacuoles; protein abundance increases in response to DNA replication stress vacuole fusion, non-autophagic endopeptidase inhibitor activity cellular_component
YDR481C YDR481C PHO8 hom Verified 1.03505170178157 0.150322383287964 no 730 0.165086259059336 573 NA FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM Repressible vacuolar alkaline phosphatase; regulated by levels of Pi and by Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides; contributes to NAD+ metabolism by producing nicotinamide riboside from NMN nicotinamide nucleotide metabolic process|protein dephosphorylation nucleotide phosphatase activity|alkaline phosphatase activity fungal-type vacuole membrane
YER063W YER063W THO1 hom Verified 1.03283616401299 0.150840288320539 no 731 0.115402670308458 418 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA LOCALIZATION NUCLEUS Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation poly(A)+ mRNA export from nucleus|transcription, DNA-dependent|ribonucleoprotein complex assembly chromatin binding|double-stranded DNA binding|RNA binding nucleus
YMR121C YMR121C RPL15B hom Verified 1.03233258047811 0.150958171700621 no 732 0.128782244796924 473 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress cytoplasmic translation structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YDR178W YDR178W SDH4 hom Verified 1.03200692240727 0.151034437319913 no 733 0.179131802921267 585 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain mitochondrial electron transport, succinate to ubiquinone|cellular respiration|tricarboxylic acid cycle succinate dehydrogenase (ubiquinone) activity mitochondrial respiratory chain complex II|mitochondrion
YPR059C_d YPR059C YPR059C hom Dubious 1.03198224668573 0.151040217153448 no 734 0.16356744506903 625 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YMC1/YPR058W Unknown Unknown Unknown
YGR042W YGR042W YGR042W hom Verified 1.03161053062487 0.151127302606789 no 735 0.123581753663659 453 NA FT NUCLEUS Protein of unknown function; involved in maintenance of proper telomere length; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; forms nuclear foci upon DNA replication stress biological_process molecular_function nucleus|cytoplasm
YNR018W YNR018W RCF2 hom Verified 1.03057573254843 0.151369910501496 no 736 0.140836452452949 512 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast mitochondrial respiratory chain complex IV assembly molecular_function mitochondrion|mitochondrial respiratory chain supercomplex|mitochondrial respiratory chain complex IV|integral to mitochondrial inner membrane
YFR043C YFR043C IRC6 hom Verified 1.030170651472 0.151464952059212 no 737 0.154160610049083 548 NA Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci biological_process molecular_function cellular_component
YPL015C YPL015C HST2 hom Verified 1.02806302321236 0.151960091435885 no 738 0.173046112429337 542 NA FT GENE SILENCING NUCLEUS Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro; contains a nuclear export signal (NES); function regulated by its nuclear export negative regulation of chromatin silencing at telomere|chronological cell aging|chromatin silencing at rDNA|negative regulation of mitotic recombination NAD-dependent histone deacetylase activity cytoplasm
YDR222W_p YDR222W YDR222W hom Uncharacterized 1.02705797938781 0.152196581833081 no 739 0.182458773203752 629 NA FT RESPONSE TO OXIDATIVE STRESS Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern biological_process molecular_function cytoplasm
YML078W YML078W CPR3 hom Verified 1.02699555253139 0.152211279151431 no 740 0.160641347817768 584 NA FT MITOCHONDRION Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; involved in protein refolding after import into mitochondria protein folding|apoptotic process peptidyl-prolyl cis-trans isomerase activity mitochondrion
YLR402W_d YLR402W YLR402W hom Dubious 1.02488910016984 0.152707759108485 no 741 0.165934270860675 537 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR366W_d YLR366W YLR366W hom Dubious 1.02457271461101 0.152782422234562 no 742 0.151793346059376 534 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR364C-A Unknown Unknown Unknown
YCL010C YCL010C SGF29 hom Verified 1.02338118742325 0.153063825341587 no 743 0.138196823343032 508 NA FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS HISTONE ACETYLTRANSFERASE Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes; HAT/Core module also contains Gcn5p, Ngg1p, and Ada2p; binds methylated histone H3K4; involved in transcriptional regulation through SAGA and TBP recruitment to target promoters and H3 acetylation histone H3-K14 acetylation|cellular protein complex localization|histone H3-K18 acetylation|cellular protein localization|histone H3-K9 acetylation|positive regulation of transcription from RNA polymerase II promoter methylated histone residue binding|RNA polymerase II transcription factor recruiting transcription factor activity Ada2/Gcn5/Ada3 transcription activator complex|SAGA complex
YBR006W YBR006W UGA2 hom Verified 1.02279936913247 0.15320135819088 no 744 0.191642874038358 719 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm cellular response to oxidative stress|gamma-aminobutyric acid catabolic process|glutamate decarboxylation to succinate succinate-semialdehyde dehydrogenase [NAD(P)+] activity cytoplasm
YDR076W YDR076W RAD55 hom Verified 1.02266621380005 0.153232845565041 no 745 0.175254418725007 625 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p DNA recombinase assembly|heteroduplex formation|meiotic DNA recombinase assembly|double-strand break repair via single-strand annealing DNA-dependent ATPase activity|protein heterodimerization activity nucleus|Rhp55-Rhp57 complex
YLR387C YLR387C REH1 hom Verified 1.02246099236454 0.153281382879629 no 746 0.185666128086435 616 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS RIBOSOME Cytoplasmic 60S subunit biogenesis factor, associates with pre-60S particles; similar to Rei1p and shares partially redundant function in cytoplasmic 60S subunit maturation; contains dispersed C2H2 zinc finger domains ribosomal large subunit biogenesis|budding cell bud growth molecular_function cytosolic large ribosomal subunit|preribosome, large subunit precursor|cytoplasm
YPL078C YPL078C ATP4 hom Verified 1.02200985510698 0.153388118022984 no 747 0.155133872234086 547 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS MITOCHONDRION Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; contributes to the oligomerization of the complex; phosphorylated protein complex oligomerization|ATP synthesis coupled proton transport proton-transporting ATPase activity, rotational mechanism mitochondrion|mitochondrial proton-transporting ATP synthase, stator stalk|integral to membrane
YBR003W YBR003W COQ1 hom Verified 1.02078352672993 0.153678505394148 no 748 0.172723097785045 620 NA FT KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM MITOCHONDRION Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis ubiquinone biosynthetic process trans-hexaprenyltranstransferase activity mitochondrion
YGL101W_p YGL101W YGL101W hom Uncharacterized 1.02053546021847 0.15373729032051 no 749 0.156276333172316 468 NA FT NUCLEUS Putative protein of unknown function; non-essential gene with similarity to YBR242W; interacts with the DNA helicase Hpr5p biological_process molecular_function nucleus|cytoplasm
YNR040W_p YNR040W YNR040W hom Uncharacterized 1.02004989437141 0.153852399124115 no 750 0.160853630729345 562 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YLR050C_p YLR050C YLR050C hom Uncharacterized 1.01777247014167 0.154393048970853 no 751 0.150357276809001 539 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLR050C is not an essential gene biological_process molecular_function integral to membrane|endoplasmic reticulum
YER050C YER050C RSM18 hom Verified 1.01750977752574 0.154455491670236 no 752 0.190655879884447 627 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YMR233W YMR233W TRI1 hom Verified 1.01588480509692 0.154842122731077 no 753 0.169523775532023 580 NA FT NUCLEUS Non-essential sumoylated protein of unknown function; similar to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus; TRI1 has a paralog, UAF30, that arose from the whole genome duplication biological_process molecular_function nucleolus|nucleus|cytoplasm
YDL162C_d YDL162C YDL162C hom Dubious 1.01558090390351 0.154914501099639 no 754 0.151117912216228 529 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps ENT1/YDL161W, a verified gene involved in endocytosis and actin cortical patch assembly Unknown Unknown Unknown
YDR200C YDR200C VPS64 hom Verified 1.01363778242813 0.15537781110068 no 755 0.197607414376581 665 NA FT PROTEIN LOCALIZATION|CELL CYCLE|SIGNALING|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein required for cytoplasm to vacuole targeting of proteins; forms a complex with Far3p and Far7p to Far11p involved in recovery from pheromone-induced cell cycle arrest; mutant has increased aneuploidy tolerance re-entry into mitotic cell cycle after pheromone arrest|protein targeting to vacuole molecular_function endoplasmic reticulum membrane|cytoplasm
YBR081C YBR081C SPT7 hom Verified 1.01189788012395 0.155793441488129 no 756 0.210554643051161 712 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION NUCLEUS|MITOCHONDRION HISTONE ACETYLTRANSFERASE Subunit of the SAGA transcriptional regulatory complex, involved in proper assembly of the complex; also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex conjugation with cellular fusion|histone acetylation|protein complex assembly|chromatin modification structural molecule activity SLIK (SAGA-like) complex|mitochondrion|SAGA complex
YLR237W YLR237W THI7 hom Verified 1.0099727796593 0.156254165773384 no 757 0.181004705192556 573 NA FT PLASMA MEMBRANE Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia thiamine transport thiamine transmembrane transporter activity integral to membrane|plasma membrane
YLR318W YLR318W EST2 hom Verified 1.0090307933588 0.156479933174459 no 758 0.152460411056371 574 NA FT NUCLEUS|CHROMOSOME Reverse transcriptase subunit of the telomerase holoenzyme, essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia telomere maintenance via telomerase|replicative cell aging telomerase activity|telomeric template RNA reverse transcriptase activity|telomeric DNA binding telomerase catalytic core complex|nucleolus|nucleus|telomerase holoenzyme complex
YGL164C YGL164C YRB30 hom Verified 1.00593564703653 0.157223263637417 no 759 0.153472187106204 537 NA FT PROTEIN LOCALIZATION NUCLEUS RanGTP-binding protein, inhibits RanGAP1 (Rna1p)-mediated GTP hydrolysis of RanGTP (Gsp1p); shares similarity to proteins in other fungi but not in higher eukaryotes biological_process GTPase regulator activity nucleus|cytoplasm
YHR038W YHR038W RRF1 hom Verified 1.00539522178803 0.157353289881913 no 760 0.174193845073403 598 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial ribosome recycling factor, essential for mitochondrial protein synthesis and for the maintenance of the respiratory function of mitochondria mitochondrial translation translation release factor activity mitochondrion
YNL066W YNL066W SUN4 hom Verified 1.004825301898 0.157490489091583 no 761 0.167354452705501 557 NA FT CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|MITOCHONDRION ORGANIZATION MITOCHONDRION Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family mitochondrion organization glucosidase activity fungal-type cell wall|mitochondrial matrix
YPL189C-A YPL189C-A COA2 hom Verified 1.00291581710872 0.157950740167907 no 762 0.151787518246256 489 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p mitochondrial respiratory chain complex IV assembly molecular_function mitochondrial matrix
YFR021W YFR021W ATG18 hom Verified 1.00291543286209 0.157950832873259 no 763 0.164957889319039 580 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION|VACUOLAR PROTEIN PROCESSING Phosphoinositide binding protein; required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein; relocalizes from vacuole to cytoplasm upon DNA replication stress; has 4 mammalian homologs WIPI1, WIPI2, WIPI3 and WIPI4/WDR45; mutations in human WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood piecemeal microautophagy of nucleus|peroxisome degradation|vacuolar protein processing|macroautophagy|late endosome to vacuole transport|CVT pathway ubiquitin binding|phosphatidylinositol binding cytosol|endosome|fungal-type vacuole membrane|PAS complex|pre-autophagosomal structure
YCR051W_p YCR051W YCR051W hom Uncharacterized 1.00049847192514 0.158534668380325 no 764 0.157107873682054 579 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; contains ankyrin (Ank) repeats; YCR051W is not an essential gene biological_process molecular_function nucleus|cytoplasm
YNL154C YNL154C YCK2 hom Verified 0.999803767907129 0.15870274101193 no 765 0.16620074169249 562 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL DIVISION|PROTEIN PHOSPHORYLATION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; YCK2 has a paralog, YCK1, that arose from the whole genome duplication endocytosis|cell morphogenesis|protein phosphorylation|cytokinesis|response to glucose stimulus protein serine/threonine kinase activity|protein kinase activity plasma membrane|cellular bud neck|mating projection
YPR022C_p YPR022C YPR022C hom Uncharacterized 0.998766753652191 0.158953847449921 no 766 0.168956047170893 553 NA FT NUCLEUS Putative transcription factor, as suggested by computational analysis; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS biological_process sequence-specific DNA binding nucleus|cytoplasm
YDL198C YDL198C GGC1 hom Verified 0.99793774408994 0.159154774026373 no 767 0.166850415967708 572 NA FT ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS MITOCHONDRION Mitochondrial GTP/GDP transporter, essential for mitochondrial genome maintenance; has a role in mitochondrial iron transport; member of the mitochondrial carrier family cellular iron ion homeostasis|mitochondrial genome maintenance|transmembrane transport|guanine nucleotide transport guanine nucleotide transmembrane transporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YHR202W_p YHR202W YHR202W hom Uncharacterized 0.997150644233116 0.159345696868834 no 768 0.159989850369639 607 NA FT NUCLEOTIDE METABOLISM Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization biological_process molecular_function cytosol|fungal-type vacuole
YOL104C YOL104C NDJ1 hom Verified 0.996427172359601 0.159521318010825 no 769 0.134856106081418 501 NA FT CELL CYCLE NUCLEUS|CHROMOSOME Meiosis-specific telomere protein, required for bouquet formation, effective homolog pairing, ordered cross-over distribution, sister chromatid cohesion at meiotic telomeres, chromosomal segregation and telomere-led rapid prophase movement meiotic telomere clustering|synapsis|attachment of telomeric heterochromatin to nuclear envelope|regulation of reciprocal meiotic recombination|reciprocal meiotic recombination telomeric DNA binding nuclear chromosome, telomeric region
YPL029W YPL029W SUV3 hom Verified 0.995430138364722 0.159763553267685 no 770 0.2219245224779 753 NA FF|FT RNA PROCESSING|MITOCHONDRION ORGANIZATION MITOCHONDRION|CHROMOSOME ATP-dependent RNA helicase, component of the mitochondrial degradosome along with the RNase Dss1p; the degradosome associates with the ribosome and mediates RNA turnover; also required during splicing of the COX1 AI5_beta intron mitochondrial DNA replication|mitochondrial RNA catabolic process|Group I intron splicing exoribonuclease II activity|ATP-dependent RNA helicase activity mitochondrion|mitochondrial chromosome|mitochondrial degradosome
YMR316W YMR316W DIA1 hom Verified 0.995022319923205 0.159862704464161 no 771 0.177395713601549 604 NA Protein of unknown function, involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern pseudohyphal growth|invasive growth in response to glucose limitation molecular_function cytoplasm
YDL013W YDL013W SLX5 hom Verified 0.994714565549176 0.159937554144149 no 772 0.208675967240264 734 NA FT RESPONSE TO DNA DAMAGE NUCLEUS UBIQUITIN LIGASE COMPLEX Subunit of the Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex, stimulated by SUMO-modified substrates; contains a RING domain and two SIMs (SUMO-interacting motifs); forms SUMO-dependent nuclear foci, including DNA repair centers protein sumoylation|telomere maintenance|response to DNA damage stimulus|protein ubiquitination SUMO binding|ubiquitin-protein ligase activity ubiquitin ligase complex|nucleus
YLR090W YLR090W XDJ1 hom Verified 0.993745312743783 0.160173438189574 no 773 0.173727215571256 586 NA FT NUCLEUS|MITOCHONDRION Chaperone with a role in facilitating mitochondrial protein import; ascomycete-specific member of the DnaJ-like family, closely related to Ydj1p; predicted to be C-terminally prenylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies protein folding chaperone binding mitochondrion|integral to mitochondrial outer membrane|nucleus
YML112W YML112W CTK3 hom Verified 0.992965419331074 0.160363403463152 no 774 0.225002939320499 765 NA FF|FT RNA PROCESSING|RESPONSE TO DNA DAMAGE|TRANSLATION|PROTEIN PHOSPHORYLATION NUCLEUS Gamma subunit of C-terminal domain kinase I; CTDK-I phosphorylates RNA polymerase II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and also phosphorylates ribosomal protein Rps2p to increase translational fidelity; protein abundance increases in response to DNA replication stress mRNA 3'-end processing|positive regulation of translational fidelity|positive regulation of transcription from RNA polymerase I promoter|positive regulation of DNA-dependent transcription, elongation|protein phosphorylation cyclin-dependent protein kinase activity nucleoplasm|nucleolus|carboxy-terminal domain protein kinase complex
YBR076W YBR076W ECM8 hom Verified 0.99190369871169 0.160622252335268 no 775 0.168305274037706 540 NA FT CELL WALL ORG/BIOGENESIS Non-essential protein of unknown function fungal-type cell wall organization molecular_function cellular_component
YGL168W YGL168W HUR1 hom Verified 0.991103001227867 0.1608176438322 no 776 0.232306217032962 784 NA FF|FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene DNA replication molecular_function cellular_component
YDL177C_p YDL177C YDL177C hom Uncharacterized 0.990126613155026 0.161056118416755 no 777 0.135783928696915 508 NA Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene biological_process molecular_function cellular_component
YKR006C YKR006C MRPL13 hom Verified 0.987798933512818 0.161625564991094 no 778 0.16190361316158 616 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YGR078C YGR078C PAC10 hom Verified 0.986646793482321 0.161907911017409 no 779 0.199856711293177 693 NA FT PROTEIN COMPLEX ORG/BIOGENESIS Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding tubulin complex assembly tubulin binding prefoldin complex|polysome|cytoplasm
YLR133W YLR133W CKI1 hom Verified 0.986379064162486 0.161973567350057 no 780 0.207921483954737 690 NA FT LIPID METABOLISM Choline kinase; catalyzes the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; CKI1 has a paralog, EKI1, that arose from the whole genome duplication phosphatidylethanolamine biosynthetic process|phosphatidylcholine biosynthetic process ethanolamine kinase activity|choline kinase activity cytoplasm
YHR048W_p YHR048W YHK8 hom Uncharacterized 0.982760173962213 0.162862743594428 no 781 0.183773024392752 619 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Presumed antiporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles drug transport molecular_function integral to membrane
YIL043C YIL043C CBR1 hom Verified 0.982290736828925 0.162978318369013 no 782 0.174581213156853 600 NA FT OXIDATION-REDUCTION PROCESS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION Microsomal cytochrome b reductase, not essential for viability; also detected in mitochondria; mutation in conserved NADH binding domain of the human ortholog results in type I methemoglobinemia biological_process cytochrome-b5 reductase activity mitochondrial outer membrane|mitochondrion
YOR064C YOR064C YNG1 hom Verified 0.981322388999237 0.163216892659615 no 783 0.169270477297218 596 NA FT CHROMATIN ORGANIZATION NUCLEUS HISTONE ACETYLTRANSFERASE Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3, has similarity to the human tumor suppressor ING1 histone acetylation|chromatin modification histone acetyltransferase activity|methylated histone residue binding NuA3 histone acetyltransferase complex
YEL033W_p YEL033W MTC7 hom Uncharacterized 0.981081408703439 0.163276298827269 no 784 0.20841442573091 718 NA Predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant biological_process molecular_function cellular_component
YJR121W YJR121W ATP2 hom Verified 0.98006130419258 0.163527929325657 no 785 0.157961801236796 559 NA FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS MITOCHONDRION Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated ATP synthesis coupled proton transport hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism proton-transporting ATP synthase complex, catalytic core F(1)|mitochondrion|mitochondrial proton-transporting ATP synthase, catalytic core|integral to membrane
YJR094W-A YJR094W-A RPL43B hom Verified 0.979707282910281 0.163615315045696 no 786 0.141357231095263 504 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L43B; homologous to mammalian ribosomal protein L37A, no bacterial homolog; RPL43B has a paralog, RPL43A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YPL089C YPL089C RLM1 hom Verified 0.97894517066906 0.163803535777528 no 787 0.201486482333278 644 NA FT TRANSCRIPTION FROM RNA POL II|SIGNALING NUCLEUS MADS-box transcription factor; component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p; RLM1 has a paralog, SMP1, that arose from the whole genome duplication signal transduction|positive regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|DNA binding, bending|sequence-specific DNA binding nucleus
YGL163C YGL163C RAD54 hom Verified 0.978023552940766 0.164031337626659 no 788 0.22997283612855 769 NA FF|FT CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS DNA-dependent ATPase that stimulates strand exchange; modifies the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family; forms nuclear foci upon DNA replication stress positive regulation of endodeoxyribonuclease activity|DNA geometric change|heteroduplex formation|telomere maintenance via recombination|double-strand break repair via synthesis-dependent strand annealing|chromatin remodeling|double-strand break repair via single-strand annealing DNA-dependent ATPase activity|DNA translocase activity nucleus
YBR057C YBR057C MUM2 hom Verified 0.977706646173197 0.164109716860058 no 789 0.172517953653288 585 NA FT CELL CYCLE Cytoplasmic protein essential for meiotic DNA replication and sporulation; interacts with Orc2p, which is a component of the origin recognition complex premeiotic DNA replication molecular_function cytoplasm
YMR282C YMR282C AEP2 hom Verified 0.976307505268729 0.164456050898262 no 790 0.201867762413814 678 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial protein, likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader mitochondrial translational initiation molecular_function mitochondrion
YOR245C YOR245C DGA1 hom Verified 0.974663089761075 0.164863703752213 no 791 0.148489036031931 499 NA FT LIPID METABOLISM|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Diacylglycerol acyltransferase, catalyzes the terminal step of triacylglycerol (TAG) formation, acylates diacylglycerol using acyl-CoA as an acyl donor, localized to lipid particles lipid storage|triglyceride biosynthetic process diacylglycerol O-acyltransferase activity integral to membrane|lipid particle
YMR243C YMR243C ZRC1 hom Verified 0.974454110947514 0.164915556716852 no 792 0.164279051569244 599 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Vacuolar membrane zinc transporter; transports zinc from cytosol to vacuole for storage; also has role in resistance to zinc shock resulting from sudden influx of zinc into cytoplasm; human ortholog SLC30A10 functions as a Mn transporter and mutations in SLC30A10 cause neurotoxic accumulation of Mn in liver and brain; ZRC1 has a paralog, COT1, that arose from the whole genome duplication cobalt ion transport|cellular zinc ion homeostasis|zinc ion transport|glutathione metabolic process zinc ion transmembrane transporter activity|inorganic cation transmembrane transporter activity integral to membrane|fungal-type vacuole
YAL047C YAL047C SPC72 hom Verified 0.974111267367091 0.165000647812553 no 793 0.171501482683684 559 NA FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION NUCLEUS|CYTOSKELETON Component of the cytoplasmic Tub4p (gamma-tubulin) complex, binds spindle pole bodies and links them to microtubules; has roles in astral microtubule formation and stabilization microtubule nucleation|nuclear migration along microtubule|mitotic cell cycle spindle orientation checkpoint|mitotic spindle elongation|mitotic sister chromatid segregation structural constituent of cytoskeleton outer plaque of spindle pole body
YLR027C YLR027C AAT2 hom Verified 0.973588067309114 0.16513055675858 no 794 0.215215716507638 703 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells aspartate biosynthetic process L-aspartate:2-oxoglutarate aminotransferase activity cytosol|peroxisome
YOL137W YOL137W BSC6 hom Verified 0.973078552487329 0.16525713131878 no 795 0.175504760922097 568 NA FT GOLGI APPARATUS Protein of unknown function containing 8 putative transmembrane seqments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression biological_process molecular_function COPI-coated vesicle|integral to membrane|clathrin-coated vesicle
YOR354C YOR354C MSC6 hom Verified 0.972849842215863 0.165313968335396 no 796 0.176138522507477 594 NA FT CELL CYCLE MITOCHONDRION Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies reciprocal meiotic recombination molecular_function mitochondrion
YMR135W-A_d YMR135W-A YMR135W-A hom Dubious 0.971876202332961 0.165556070074249 no 797 0.130616194932822 427 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR114C_p YDR114C YDR114C hom Uncharacterized 0.971626218183524 0.165618267199008 no 798 0.184986788865934 638 NA Putative protein of unknown function; deletion mutant exhibits poor growth at elevated pH and calcium biological_process molecular_function cellular_component
YDR112W_d YDR112W IRC2 hom Dubious 0.97083544676312 0.165815113996971 no 799 0.160303258872588 576 NA Dubious open reading frame, unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR111C; null mutant displays increased levels of spontaneous Rad52p foci Unknown Unknown Unknown
YLR264W YLR264W RPS28B hom Verified 0.969161960851256 0.166232193483768 no 800 0.162571451476666 560 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S28, no bacterial homolog; RPS28B has a paralog, RPS28A, that arose from the whole genome duplication cytoplasmic translation|rRNA export from nucleus structural constituent of ribosome cytosolic small ribosomal subunit
YDR320C YDR320C SWA2 hom Verified 0.964736701593408 0.167338353723987 no 801 0.228950286079549 752 NA FF|FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|NUCLEOTIDE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles positive regulation of ATPase activity|endoplasmic reticulum inheritance|clathrin coat disassembly ubiquitin binding|clathrin binding endoplasmic reticulum membrane
YHL005C_d YHL005C YHL005C hom Dubious 0.963747681970057 0.167586221175793 no 802 0.147669189729945 545 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YHL004W Unknown Unknown Unknown
YLR028C YLR028C ADE16 hom Verified 0.963666180724376 0.167606657506759 no 803 0.157409807061951 507 NA FT OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE16 has a paralog, ADE17, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine ascospore formation|'de novo' IMP biosynthetic process|purine nucleotide biosynthetic process|aerobic respiration phosphoribosylaminoimidazolecarboxamide formyltransferase activity|IMP cyclohydrolase activity cytosol
YHR127W YHR127W YHR127W hom Verified 0.963492492486649 0.167650214960952 no 804 0.156740235662893 513 NA FT CELL CYCLE|CYTOSKELETON ORGANIZATION NUCLEUS Protein of unknown function; localizes to the nucleus; required for asymmetric localization of Kar9p during mitosis mitotic spindle elongation molecular_function nucleus
YDR306C_p YDR306C YDR306C hom Uncharacterized 0.960613121136292 0.168373364410046 no 805 0.186276328393101 611 NA FT PROTEOLYSIS F-box protein of unknown function; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity|protein binding, bridging SCF ubiquitin ligase complex
YDR466W YDR466W PKH3 hom Verified 0.960023267282049 0.168521752452369 no 806 0.227502387496202 781 NA FF|FT SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant MAPK cascade involved in cell wall biogenesis|protein phosphorylation protein kinase activity cellular_component
YAR029W_p YAR029W YAR029W hom Uncharacterized 0.959659468946445 0.168613314186197 no 807 0.15872937302096 566 NA Member of DUP240 gene family but contains no transmembrane domains; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern biological_process molecular_function cytoplasm
YLR139C YLR139C SLS1 hom Verified 0.958823265206768 0.168823893370628 no 808 0.199578269525958 682 NA FT TRANSLATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Mitochondrial membrane protein that coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translation machinery aerobic respiration|mitochondrial translation molecular_function mitochondrial nucleoid|mitochondrion|integral to membrane|mitochondrial inner membrane
YML030W YML030W RCF1 hom Verified 0.958467190511214 0.168913614083732 no 809 0.165206453903732 607 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Cytochrome c oxidase subunit; required for assembly of the Complex III-Complex IV supercomplex, and for assembly of Cox13p and Rcf2p into cytochrome c oxidase; similar to Rcf2p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; required for growth under hypoxic conditions; member of the hypoxia induced gene family; C. elegans and human orthologs are functional in yeast mitochondrial respiratory chain complex IV assembly|mitochondrial respiratory chain supercomplex assembly molecular_function mitochondrion|mitochondrial respiratory chain supercomplex|integral to mitochondrial inner membrane|mitochondrial respiratory chain complex IV
YEL050C YEL050C RML2 hom Verified 0.95741760671586 0.169178257579873 no 810 0.213549453796201 736 NA FF|FT KETONE METABOLISM|LIPID METABOLISM|TRANSLATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor cytoplasmic translation|fatty acid metabolic process structural constituent of ribosome mitochondrial large ribosomal subunit
YGL002W YGL002W ERP6 hom Verified 0.957339181221745 0.169198042574963 no 811 0.180982930509277 574 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication ER to Golgi vesicle-mediated transport molecular_function mitochondrion|integral to membrane
YHL031C YHL031C GOS1 hom Verified 0.957039326567127 0.169273702884114 no 812 0.252943647620371 899 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|GOLGI APPARATUS v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28 Golgi vesicle transport|vesicle fusion SNAP receptor activity SNARE complex|integral to membrane|Golgi medial cisterna
YJR108W YJR108W ABM1 hom Verified 0.95698555165854 0.169287273841699 no 813 0.153807122481195 532 NA FT CYTOSKELETON ORGANIZATION Protein of unknown function, required for normal microtubule organization microtubule cytoskeleton organization molecular_function cellular_component
YER093C-A YER093C-A AIM11 hom Verified 0.956561302193836 0.169394364463988 no 814 0.161184860377773 573 NA Protein of unknown function; null mutant is viable but shows increased loss of mitochondrial genome and synthetic interaction with prohibitin (phb1); contains an intron; YER093C-A has a paralog, YBL059W, that arose from the whole genome duplication biological_process molecular_function cellular_component
YOR053W_d YOR053W YOR053W hom Dubious 0.956278496562024 0.169465775455686 no 815 0.155544862184757 589 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VHS3/YOR054C Unknown Unknown Unknown
YNR032W YNR032W PPG1 hom Verified 0.955797376563364 0.169587307007447 no 816 0.165235254175565 520 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Putative serine/threonine protein phosphatase of the type 2A-like phosphatase family, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases glycogen metabolic process|protein dephosphorylation protein serine/threonine phosphatase activity nucleus|cytoplasm
YPL170W YPL170W DAP1 hom Verified 0.955644943455359 0.16962582347439 no 817 0.196585433186473 699 NA FT LIPID METABOLISM Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis regulation of ergosterol biosynthetic process heme binding endosome|membrane
YHR028C YHR028C DAP2 hom Verified 0.955498467068322 0.16966284009656 no 818 0.193399288329399 649 NA FT PROTEOLYSIS Dipeptidyl aminopeptidase, synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p protein processing dipeptidyl-peptidase activity fungal-type vacuole membrane
YHR104W YHR104W GRE3 hom Verified 0.955317523443319 0.169708574222918 no 819 0.16697024170703 607 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS NUCLEUS Aldose reductase; involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress galactose catabolic process|cellular response to oxidative stress|arabinose catabolic process|D-xylose catabolic process|response to stress D-xylose:NADP reductase activity|mRNA binding|glucose 1-dehydrogenase (NADP+) activity|alditol:NADP+ 1-oxidoreductase activity nucleus|cytoplasm
YBL045C YBL045C COR1 hom Verified 0.955116678300091 0.169759347785178 no 820 0.18025845838649 579 NA FT OXIDATION-REDUCTION PROCESS|PROTEOLYSIS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Core subunit of the ubiquinol-cytochrome c reductase complex (bc1 complex), which is a component of the mitochondrial inner membrane electron transport chain aerobic respiration ubiquinol-cytochrome-c reductase activity mitochondrion|integral to membrane|mitochondrial respiratory chain complex III
YNL070W YNL070W TOM7 hom Verified 0.954794604981222 0.169840788110356 no 821 0.190079874267763 674 NA FF|FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex protein import into mitochondrial matrix|protein import into mitochondrial outer membrane protein channel activity mitochondrial outer membrane|mitochondrion|integral to membrane|mitochondrial outer membrane translocase complex
YLR021W YLR021W IRC25 hom Verified 0.954287324499837 0.169969111211039 no 822 0.178133112180706 614 NA FT PROTEIN COMPLEX ORG/BIOGENESIS Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions proteasome assembly|chaperone-mediated protein complex assembly|nuclear-transcribed mRNA catabolic process, non-stop decay molecular_function intracellular
YPR061C YPR061C JID1 hom Verified 0.95404272343501 0.170031008389514 no 823 0.164466684284362 612 NA FT MITOCHONDRION Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae biological_process molecular_function mitochondrion
YER057C YER057C HMF1 hom Verified 0.953694094627531 0.170119255130233 no 824 0.137336916136682 465 NA FT NUCLEUS Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro biological_process molecular_function cytosol|nucleus|cytoplasm
YDR215C_d YDR215C YDR215C hom Dubious 0.953419650251717 0.170188744564372 no 825 0.1699664936302 530 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein Unknown Unknown Unknown
YER071C_p YER071C TDA2 hom Uncharacterized 0.952130134396919 0.170515493986265 no 826 0.1565193885919 454 NA FT SITE OF POLARIZED GROWTH Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele biological_process molecular_function mating projection tip|cytoplasm
YCR048W YCR048W ARE1 hom Verified 0.951886418430535 0.170577294091198 no 827 0.136181046957531 478 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the absence of oxygen; ARE1 has a paralog, ARE2, that arose from the whole genome duplication sterol metabolic process ergosterol O-acyltransferase activity|lanosterol O-acyltransferase activity integral to membrane|endoplasmic reticulum
YGL190C YGL190C CDC55 hom Verified 0.951846074552289 0.170587525645029 no 828 0.243568192159556 836 NA FT CELL CYCLE|SIGNALING NUCLEUS|SITE OF POLARIZED GROWTH Non-essential regulatory subunit B of protein phosphatase 2A (PP2A); localization to the cytoplasm requires Zds1p and Zds2p and promotes mitotic entry; localization to the nucleus prevents mitotic exit; required for correct nuclear division and chromosome segregation in meiosis; maintains nucleolar sequestration of Cdc14p during early meiosis; limits formation of PP2A-Rts1p holocomplexes to ensure timely dissolution of sister chromosome cohesion negative regulation of exit from mitosis|positive regulation of G2/M transition of mitotic cell cycle|cell shape checkpoint|protein dephosphorylation protein phosphatase type 2A regulator activity nucleus|cellular bud neck|cytoplasm|cellular bud tip
YOR367W YOR367W SCP1 hom Verified 0.950340875994433 0.170969537697487 no 829 0.190292715952312 668 NA FT CYTOSKELETON ORGANIZATION CYTOSKELETON Component of yeast cortical actin cytoskeleton, binds and cross links actin filaments; originally identified by its homology to calponin (contains a calponin-like repeat) but the Scp1p domain structure is more similar to transgelin actin filament organization|chronological cell aging actin filament binding|protein binding, bridging actin cortical patch
YAR030C_d YAR030C YAR030C hom Dubious 0.948919865027465 0.171330685169297 no 830 0.163920978107903 591 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YAR029W and the verified gene PRM9 Unknown Unknown Unknown
YDR445C_d YDR445C YDR445C hom Dubious 0.948459104360969 0.171447891318491 no 831 0.194158505888517 631 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YBL069W YBL069W AST1 hom Verified 0.948393134020412 0.171464676738794 no 832 0.150696766187959 554 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS GOLGI APPARATUS|PLASMA MEMBRANE Lipid raft associated protein; interacts with the plasma membrane ATPase Pma1p and has a role in its targeting to the plasma membrane by influencing its incorporation into lipid rafts; sometimes classified in the medium-chain dehydrogenase/reductases (MDRs) superfamily; AST1 has a paralog, AST2, that arose from the whole genome duplication protein targeting to membrane|protein transport into membrane raft molecular_function late endosome|membrane raft|Golgi apparatus|plasma membrane
YLR351C YLR351C NIT3 hom Verified 0.94817204597046 0.171520937794609 no 833 0.151582245935749 534 NA FT MITOCHONDRION Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member biological_process hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds mitochondrion|cytoplasm
YNL212W YNL212W VID27 hom Verified 0.948043459336048 0.17155366511406 no 834 0.16976144511227 599 NA Cytoplasmic protein of unknown function; possibly involved in vacuolar protein degradation; not essential for proteasome-dependent degradation of fructose-1,6-bisphosphatase (FBPase); null mutants exhibit normal growth biological_process molecular_function cytoplasm
YIR042C_p YIR042C YIR042C hom Uncharacterized 0.946929665152491 0.171837310188209 no 835 0.157894859759995 523 NA Putative protein of unknown function; YIR042C is a non-essential gene biological_process molecular_function cellular_component
YOL155C YOL155C HPF1 hom Verified 0.94685225019463 0.171857036241022 no 836 0.180836740929289 672 NA FT CELL WALL ORG/BIOGENESIS Haze-protective mannoprotein that reduces the particle size of aggregated proteins in white wines fungal-type cell wall organization glucosidase activity fungal-type cell wall|extracellular region
YPL154C YPL154C PEP4 hom Verified 0.946737402530622 0.171886303160044 no 837 0.18426654373853 657 NA FT MEMBRANE ORGANIZATION|PROTEOLYSIS|RESPONSE TO NUTRIENT LEVELS MITOCHONDRION Vacuolar aspartyl protease (proteinase A), required for the posttranslational precursor maturation of vacuolar proteinases; important for protein turnover after oxidative damage; synthesized as a zymogen, self-activates microautophagy|proteolysis involved in cellular protein catabolic process|cellular response to starvation peptidase activity fungal-type vacuole lumen|mitochondrion|fungal-type vacuole
YKL048C YKL048C ELM1 hom Verified 0.94668932308271 0.171898556311659 no 838 0.175733862381132 652 NA FT CELL CYCLE|CELL DIVISION|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION SITE OF POLARIZED GROWTH|CYTOSKELETON Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases, such as Kin4p; forms part of the bud neck ring positive regulation of protein autophosphorylation|protein autophosphorylation|cell morphogenesis|budding cell bud growth|protein phosphorylation|response to drug|septin checkpoint|pseudohyphal growth|glucose metabolic process|axial cellular bud site selection|response to osmotic stress|cytokinesis protein serine/threonine kinase activity|protein kinase activity cellular bud neck contractile ring
YCR024C YCR024C SLM5 hom Verified 0.946471660319043 0.171954035117014 no 839 0.19732338702154 702 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial asparaginyl-tRNA synthetase asparaginyl-tRNA aminoacylation|mitochondrial asparaginyl-tRNA aminoacylation asparagine-tRNA ligase activity mitochondrion
YBR183W YBR183W YPC1 hom Verified 0.94390387242052 0.172609386495843 no 840 0.182569607429664 624 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Alkaline ceramidase; also has reverse (CoA-independent) ceramide synthase activity; catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistance; YPC1 has a paralog, YDC1, that arose from the whole genome duplication ceramide catabolic process|ceramide biosynthetic process phytoceramidase activity|sphingosine N-acyltransferase activity integral to membrane|endoplasmic reticulum
YBR018C YBR018C GAL7 hom Verified 0.943401447931565 0.172737801424593 no 841 0.168136512088568 604 NA FT CARBOHYDRATE METABOLISM Galactose-1-phosphate uridyl transferase, synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism galactose catabolic process via UDP-galactose UDP-glucose:hexose-1-phosphate uridylyltransferase activity cytoplasm
YBL102W YBL102W SFT2 hom Verified 0.942990241558785 0.172842947174003 no 842 0.191401275786395 652 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Non-essential tetra-spanning membrane protein found mostly in the late Golgi, can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to mammalian syntaxin 5 Golgi to endosome transport molecular_function integral to membrane|Golgi membrane
YMR228W YMR228W MTF1 hom Verified 0.94298971014794 0.172843083082502 no 843 0.160697461734977 583 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation transcription initiation from mitochondrial promoter mitochondrial RNA polymerase binding promoter specificity activity mitochondrion|mitochondrial DNA-directed RNA polymerase complex|mitochondrial matrix|mitochondrial intermembrane space
YDL185W YDL185W VMA1 hom Verified 0.94263255943674 0.172934439899143 no 844 0.251444962811144 872 NA FF|FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM Subunit A of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease intron homing|cellular protein metabolic process|vacuolar acidification endodeoxyribonuclease activity|proton-transporting ATPase activity, rotational mechanism vacuolar proton-transporting V-type ATPase, V1 domain|fungal-type vacuole membrane
YER042W YER042W MXR1 hom Verified 0.941976758081759 0.173102269697423 no 845 0.191624158109898 647 NA FT OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS NUCLEUS Methionine-S-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR2; involved in the regulation of lifespan cellular response to oxidative stress peptide-methionine-(S)-S-oxide reductase activity nucleus|cytoplasm
YCR091W YCR091W KIN82 hom Verified 0.940393187144384 0.173507957758306 no 846 0.152944803264889 556 NA FT MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION Putative serine/threonine protein kinase implicated in the regulation of phospholipid asymmetry through the activation of phospholipid translocases (flippases) Lem3p-Dnf1p/Dnf2p; similar to Fpk1p phospholipid translocation|protein phosphorylation|response to pheromone protein kinase activity cellular_component
YLR239C YLR239C LIP2 hom Verified 0.938345992982649 0.174033315406812 no 847 0.251853502335057 859 NA FF|FT KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM MITOCHONDRION Lipoyl ligase, involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups protein lipoylation ligase activity mitochondrion
YDL037C YDL037C BSC1 hom Verified 0.938029306967479 0.174114674631932 no 848 0.176296848872959 606 NA Protein of unconfirmed function, similar to cell surface flocculin Flo11p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression biological_process molecular_function cellular_component
YDR185C YDR185C UPS3 hom Verified 0.937555327172139 0.174236489077092 no 849 0.175222523563645 606 NA FT MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial protein of unknown function; similar to Ups1p and Ups2p which are involved in regulation of mitochondrial cardiolipin and phosphatidylethanolamine levels; null is viable but interacts synthetically with ups1 and ups2 mutations mitochondrion morphogenesis molecular_function extrinsic to mitochondrial inner membrane|mitochondrion|mitochondrial intermembrane space
YDR100W YDR100W TVP15 hom Verified 0.93713104250419 0.174345577629457 no 850 0.174290598648694 546 NA FT VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p vesicle-mediated transport molecular_function COPI-coated vesicle|integral to membrane|integral to Golgi membrane
YGR135W YGR135W PRE9 hom Verified 0.936111891294391 0.174607790586815 no 851 0.177556495568231 614 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION Alpha 3 subunit of the 20S proteasome, the only nonessential 20S subunit; may be replaced by the alpha 4 subunit (Pre6p) under stress conditions to create a more active proteasomal isoform proteasomal ubiquitin-dependent protein catabolic process|proteasome core complex assembly|proteasomal ubiquitin-independent protein catabolic process molecular_function mitochondrion|proteasome core complex, alpha-subunit complex|proteasome storage granule|nucleus|nuclear outer membrane-endoplasmic reticulum membrane network
YCR004C YCR004C YCP4 hom Verified 0.935634045246664 0.174730819693116 no 852 0.164957827026076 536 NA FT OXIDATION-REDUCTION PROCESS MITOCHONDRION Protein of unknown function, has sequence and structural similarity to flavodoxins; predicted to be palmitoylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process electron carrier activity mitochondrion|membrane raft|plasma membrane|cytoplasm
YBL029C-A YBL029C-A YBL029C-A hom Verified 0.933717167869602 0.175224903413672 no 853 0.177801315987805 589 NA FT PLASMA MEMBRANE Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; protein abundance increases in response to DNA replication stress; has potential orthologs in Saccharomyces species and in Yarrowia lipolytica biological_process molecular_function plasma membrane
YHL032C YHL032C GUT1 hom Verified 0.933177849727335 0.175364074634775 no 854 0.167816289150343 590 NA FT CARBOHYDRATE METABOLISM MITOCHONDRION Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p glycerol metabolic process glycerol kinase activity mitochondrion|cytoplasm
YBR015C YBR015C MNN2 hom Verified 0.932569462432369 0.175521153265585 no 855 0.247422380975112 876 NA FF|FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment protein glycosylation alpha-1,2-mannosyltransferase activity Golgi apparatus
YIL166C_p YIL166C YIL166C hom Uncharacterized 0.931334076729663 0.175840389992498 no 856 0.177140256418137 578 NA Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; YIL166C is a non-essential gene transport transporter activity integral to membrane|membrane
YLR328W YLR328W NMA1 hom Verified 0.931106324727884 0.175899283641665 no 857 0.209014391144823 624 NA FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM NUCLEUS Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways; NMA1 has a paralog, NMA2, that arose from the whole genome duplication NAD biosynthetic process nicotinamide-nucleotide adenylyltransferase activity nucleus|cytoplasm
YPR053C_d YPR053C YPR053C hom Dubious 0.93109463040385 0.17590230797601 no 858 0.163949876559563 607 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene NHP6A/YPR052C Unknown Unknown Unknown
YBR045C YBR045C GIP1 hom Verified 0.928866019148817 0.176479262616913 no 859 0.191208762046298 692 NA FT CELL WALL ORG/BIOGENESIS Meiosis-specific regulatory subunit of the Glc7p protein phosphatase, regulates spore wall formation and septin organization, required for expression of some late meiotic genes and for normal localization of Glc7p ascospore wall assembly|regulation of phosphoprotein phosphatase activity protein phosphatase type 1 regulator activity|protein phosphatase 1 binding protein phosphatase type 1 complex|prospore membrane
YPL022W YPL022W RAD1 hom Verified 0.928808763471783 0.17649410102287 no 860 0.175865707981093 597 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein mitotic recombination|meiotic mismatch repair|nucleotide-excision repair, DNA incision, 5'-to lesion|double-strand break repair via single-strand annealing, removal of nonhomologous ends|removal of nonhomologous ends single-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity nucleotide-excision repair factor 1 complex|nucleus
YMR080C YMR080C NAM7 hom Verified 0.928401336333302 0.176599712802219 no 861 0.19600139127479 631 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|RNA LOCALIZATION|GENE SILENCING NUCLEUS ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance; forms cytoplasmic foci upon DNA replication stress nuclear-transcribed mRNA catabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|intracellular mRNA localization|translational frameshifting|regulation of translational termination|chromatin silencing at silent mating-type cassette|protein ubiquitination RNA-dependent ATPase activity|ATP-dependent RNA helicase activity|nucleic acid binding mitochondrion|polysome|cytoplasm
YPR045C YPR045C THP3 hom Verified 0.928357390829891 0.176611106582907 no 862 0.172382055463437 611 NA FT RNA PROCESSING NUCLEUS|CHROMOSOME Protein that forms a complex with Csn12p that is recruited to transcribed genes and may have a role in transcription elongation; possibly involved in splicing based on pre-mRNA accumulation defect for many intron-containing genes mRNA splicing, via spliceosome molecular_function nucleus|transcriptionally active chromatin
YDR253C YDR253C MET32 hom Verified 0.927410126530108 0.176856817441403 no 863 0.199178080162095 694 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CELL CYCLE|AMINO ACID METABOLISM NUCLEUS Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; MET32 has a paralog, MET31, that arose from the whole genome duplication regulation of mitotic cell cycle|regulation of sulfur amino acid metabolic process|regulation of transcription from RNA polymerase II promoter core promoter proximal region sequence-specific DNA binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity nucleus|cytoplasm
YGR165W YGR165W MRPS35 hom Verified 0.927273604230003 0.176892247762123 no 864 0.219283914694755 749 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YBL086C_p YBL086C YBL086C hom Uncharacterized 0.926638226183332 0.177057200335893 no 865 0.156418236848828 501 NA Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery biological_process molecular_function cellular_component
YPR018W YPR018W RLF2 hom Verified 0.926125662467904 0.177190339474714 no 866 0.169895042533806 574 NA FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1); chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription DNA replication-dependent nucleosome assembly histone binding chromosome, centromeric region|nucleus|CAF-1 complex
YMR207C YMR207C HFA1 hom Verified 0.925677709900817 0.177306747543125 no 867 0.164503613850088 609 NA FT KETONE METABOLISM|LIPID METABOLISM MITOCHONDRION Mitochondrial acetyl-coenzyme A carboxylase; catalyzes the production of malonyl-CoA in mitochondrial fatty acid biosynthesis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress fatty acid biosynthetic process acetyl-CoA carboxylase activity mitochondrion
YDL085C-A_p YDL085C-A YDL085C-A hom Uncharacterized 0.925163761978903 0.177440365096104 no 868 0.181934797693916 616 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus biological_process molecular_function nucleus|cytoplasm
YBR224W_d YBR224W YBR224W hom Dubious 0.92220331339671 0.178211267558898 no 869 0.162188290228296 575 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TDP1 Unknown Unknown Unknown
YMR241W YMR241W YHM2 hom Verified 0.922118980324413 0.178233258816247 no 870 0.183846808508313 628 NA FT ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS MITOCHONDRION Carrier protein that exports citrate from and imports oxoglutarate into the mitochondrion, causing net export of NADPH reducing equivalents; also associates with mt nucleoids and has a role in replication and segregation of the mt genome tricarboxylic acid transport|mitochondrial citrate transport|alpha-ketoglutarate transport|mitochondrial genome maintenance tricarboxylate secondary active transmembrane transporter activity|DNA binding mitochondrial nucleoid|mitochondrion|integral to membrane|mitochondrial inner membrane
YDR477W YDR477W SNF1 hom Verified 0.921400331392378 0.178420727909886 no 871 0.173759735075533 534 NA FT KETONE METABOLISM|SIGNALING|TRANSLATION|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION AMP-activated serine/threonine protein kinase; found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; regulates filamentous growth in response to starvation negative regulation of translation|protein phosphorylation|replicative cell aging|signal transduction|biofilm formation|positive regulation of gluconeogenesis|pseudohyphal growth|cell adhesion|regulation of carbohydrate metabolic process|invasive growth in response to glucose limitation|cellular response to nitrogen starvation AMP-activated protein kinase activity|protein kinase activity mitochondrion|AMP-activated protein kinase complex|nucleus|nuclear envelope lumen|fungal-type vacuole|cytoplasm
YHR152W YHR152W SPO12 hom Verified 0.921209119661514 0.178470628938725 no 872 0.17900976169409 611 NA FT CELL CYCLE NUCLEUS Nucleolar protein of unknown function, positive regulator of mitotic exit; involved in regulating release of Cdc14p from the nucleolus in early anaphase, may play similar role in meiosis regulation of exit from mitosis|mitotic cell cycle|meiosis I molecular_function nucleolus|nucleus
YOL062C YOL062C APM4 hom Verified 0.921187695295751 0.178476220659525 no 873 0.156570103086104 578 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|PLASMA MEMBRANE Mu2-like subunit of the clathrin associated protein complex (AP-2); involved in vesicle transport intracellular protein transport|vesicle-mediated transport molecular_function AP-2 adaptor complex
YBR274W YBR274W CHK1 hom Verified 0.920888311474919 0.17855437084235 no 874 0.163561644154347 528 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION NUCLEUS Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase protein phosphorylation|replication fork protection|DNA damage checkpoint protein serine/threonine kinase activity nucleus
YBR210W YBR210W ERV15 hom Verified 0.919578618656941 0.178896502127921 no 875 0.158351436819211 505 NA FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|SIGNALING|CELL DIVISION Protein involved in export of proteins from the endoplasmic reticulum; ERV15 has a paralog, ERV14, that arose from the whole genome duplication ER to Golgi vesicle-mediated transport|axial cellular bud site selection molecular_function integral to membrane|ER to Golgi transport vesicle
YDR465C YDR465C RMT2 hom Verified 0.919562377283882 0.178900747452998 no 876 0.205078416968015 619 NA FT NUCLEUS Arginine N5 methyltransferase; methylates ribosomal protein Rpl12 (L12) on Arg67; relative distribution to the nucleus increases upon DNA replication stress peptidyl-arginine methylation protein-arginine N5-methyltransferase activity nucleus|cytoplasm
YEL008W_d YEL008W YEL008W hom Dubious 0.919458208149645 0.178927977682812 no 877 0.160146546083839 550 NA Hypothetical protein predicted to be involved in metabolism Unknown Unknown Unknown
YER114C YER114C BOI2 hom Verified 0.919425607776399 0.178936500087091 no 878 0.213841485689089 716 NA FT SIGNALING|CELL DIVISION SITE OF POLARIZED GROWTH|CYTOSKELETON Protein implicated in polar growth, functionally redundant with Boi1p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; BOI2 has a paralog, BOI1, that arose from the whole genome duplication cytokinesis, completion of separation|establishment of cell polarity|budding cell apical bud growth|Rho protein signal transduction phospholipid binding site of polarized growth|cellular bud|cellular bud neck
YOR376W-A_p YOR376W-A YOR376W-A hom Uncharacterized 0.91877925465105 0.179105522751128 no 879 0.15929357275517 529 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YNL148C YNL148C ALF1 hom Verified 0.917513326570202 0.179436856424328 no 880 0.230067842785644 829 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS NUCLEUS|CYTOSKELETON Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance protein folding|post-chaperonin tubulin folding pathway microtubule binding|alpha-tubulin binding nucleus|cytoplasm
YKR001C YKR001C VPS1 hom Verified 0.915967856323828 0.179841877176011 no 881 0.271652166436143 907 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION|VACUOLAR TRANSPORT|PEROXISOME ORGANIZATION MITOCHONDRION|CYTOSKELETON Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, endocytosis, late Golgi-retention of some proteins, regulation of peroxisome biogenesis vacuolar transport|peroxisome fission|endocytosis|actin cytoskeleton organization|protein retention in Golgi apparatus|peroxisome organization|lipid tube assembly|protein targeting to vacuole GTPase activity mitochondrial outer membrane|fungal-type vacuole membrane|peroxisome|actin cortical patch
YMR052C-A_d YMR052C-A YMR052C-A hom Dubious 0.914581243131721 0.180205754650915 no 882 0.179587825599688 666 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPR046W YPR046W MCM16 hom Verified 0.914345622873952 0.18026763243487 no 883 0.225370174357345 799 NA FT CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME KINETOCHORE Component of the Ctf19 complex and the COMA subcomplex; involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-H and fission yeast fta3 chromosome segregation|establishment of mitotic sister chromatid cohesion molecular_function condensed nuclear chromosome kinetochore
YER164W YER164W CHD1 hom Verified 0.914088371359568 0.180335206169661 no 884 0.202954766127711 696 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION NUCLEUS|MITOCHONDRION|CHROMOSOME HISTONE ACETYLTRANSFERASE Chromatin remodeler that regulates various aspects of transcription; acts in in conjunction with Isw1b to regulate chromatin structure and maintain chromatin integrity during transcription elongation by RNAP II by preventing trans-histone exchange over coding regions; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SLIK complexes termination of RNA polymerase I transcription|ATP-dependent chromatin remodeling|nucleosome positioning|negative regulation of histone H3-K14 acetylation|termination of RNA polymerase II transcription|regulation of transcription by chromatin organization|regulation of transcriptional start site selection at RNA polymerase II promoter|nucleosome mobilization|Unknown|transcription elongation from RNA polymerase II promoter chromatin DNA binding|DNA-dependent ATPase activity|methylated histone residue binding|DNA binding|rDNA binding nuclear chromatin|SLIK (SAGA-like) complex|mitochondrion|SAGA complex|nucleolar chromatin
YGR146C YGR146C ECL1 hom Verified 0.913855410836983 0.180396412961787 no 885 0.188441210825908 620 NA Protein of unknown function; mitochondrial-dependent role in the extension of chronological lifespan; overexpression increases oxygen consumption and respiratory activity while deletion results in reduced oxygen consumption under conditions of caloric restriction; induced by iron homeostasis transcription factor Aft2p; multicopy suppressor of temperature sensitive hsf1 mutant; induced by treatment with 8-methoxypsoralen and UVA irradiation biological_process molecular_function cellular_component
YPL062W_d YPL062W YPL062W hom Dubious 0.913779933823065 0.180416246180726 no 886 0.207999683581399 721 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPL062W is not an essential gene; homozygous diploid mutant shows a decrease in glycogen accumulation Unknown Unknown Unknown
YOL109W YOL109W ZEO1 hom Verified 0.913300805358678 0.180542179457352 no 887 0.187367553503302 624 NA FT CELL WALL ORG/BIOGENESIS MITOCHONDRION|PLASMA MEMBRANE Peripheral membrane protein of the plasma membrane that interacts with Mid2p; regulates the cell integrity pathway mediated by Pkc1p and Slt2p; the authentic protein is detected in a phosphorylated state in highly purified mitochondria fungal-type cell wall organization|response to stress molecular_function mitochondrial outer membrane|mitochondrion|extrinsic to plasma membrane|plasma membrane
YDR260C YDR260C SWM1 hom Verified 0.911945152783822 0.180898795369215 no 888 0.185181329224707 637 NA FT CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|PROTEOLYSIS NUCLEUS UBIQUITIN LIGASE COMPLEX Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation ascospore wall assembly|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|regulation of mitotic metaphase/anaphase transition|protein ubiquitination molecular_function anaphase-promoting complex|nucleus
YIL071C YIL071C PCI8 hom Verified 0.911489440026309 0.181018773555386 no 889 0.193296245353444 671 NA FT NUCLEUS Possible shared subunit of Cop9 signalosome (CSN) and eIF3, binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain cullin deneddylation molecular_function signalosome
YDR205W YDR205W MSC2 hom Verified 0.911394036076333 0.181043897426329 no 890 0.188368683112056 657 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids cellular zinc ion homeostasis|zinc ion transport|transmembrane transport zinc ion transmembrane transporter activity|metal ion transmembrane transporter activity integral to membrane|endoplasmic reticulum
YGR118W YGR118W RPS23A hom Verified 0.910640659606093 0.18124236986095 no 891 0.191514683791247 646 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23A has a paralog, RPS23B, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|regulation of translational fidelity structural constituent of ribosome cytosolic small ribosomal subunit
YML101C-A_d YML101C-A YML101C-A hom Dubious 0.909844795683975 0.181452183304066 no 892 0.170734076926942 571 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOL103W YOL103W ITR2 hom Verified 0.909286989901888 0.181599328120685 no 893 0.184214284418141 628 NA FT PLASMA MEMBRANE Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively myo-inositol transport myo-inositol transmembrane transporter activity integral to membrane|plasma membrane|membrane
YOL113W YOL113W SKM1 hom Verified 0.909206391194434 0.18162059560413 no 894 0.196948915879951 707 NA FT CELL DIVISION|PROTEIN PHOSPHORYLATION NUCLEUS|PLASMA MEMBRANE Member of the PAK family of serine/threonine protein kinases with similarity to Ste20p and Cla4p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth negative regulation of gene expression|cytokinetic cell separation|protein phosphorylation|sterol import protein serine/threonine kinase activity|protein kinase activity plasma membrane|nucleus
YPR195C_d YPR195C YPR195C hom Dubious 0.908100686221046 0.181912513979476 no 895 0.172606063878704 572 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YNR031C YNR031C SSK2 hom Verified 0.907883428323994 0.181969906947755 no 896 0.179761969180786 648 NA FT SIGNALING|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION SITE OF POLARIZED GROWTH MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress MAPK cascade involved in osmosensory signaling pathway|protein autophosphorylation|protein phosphorylation|response to osmotic stress|actin cytoskeleton organization|osmosensory signaling pathway via two-component system MAP kinase kinase kinase activity cytosol|cellular bud neck|cellular bud tip
YGL218W_d YGL218W YGL218W hom Dubious 0.906577467124927 0.182315140969588 no 897 0.22429268254374 761 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 93% of ORF overlaps the verified gene MDM34; deletion in cyr1 mutant results in loss of stress resistance Unknown Unknown Unknown
YDR226W YDR226W ADK1 hom Verified 0.906402588592315 0.182361401587534 no 898 0.193091520506666 701 NA FT NUCLEOTIDE METABOLISM MITOCHONDRION Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence; protein abundance increases in response to DNA replication stress ADP biosynthetic process|DNA replication initiation|nucleotide metabolic process adenylate kinase activity mitochondrion|mitochondrial intermembrane space|cytoplasm
YCR081W YCR081W SRB8 hom Verified 0.906057875768599 0.182452609944331 no 899 0.199576095515145 706 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS NUCLEUS Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in glucose repression negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription by galactose|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription coactivator activity mediator complex
YGR012W YGR012W YGR012W hom Verified 0.904657316406434 0.182823480184277 no 900 0.167423569605966 557 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Putative cysteine synthase, localized to the mitochondrial outer membrane cysteine biosynthetic process cysteine synthase activity mitochondrial outer membrane|mitochondrion
YOL089C YOL089C HAL9 hom Verified 0.902410706530579 0.183419367874656 no 901 0.150721593995586 576 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS|MITOCHONDRION Putative transcription factor containing a zinc finger; overexpression increases salt tolerance through increased expression of the ENA1 (Na+/Li+ extrusion pump) gene while gene disruption decreases both salt tolerance and ENA1 expression; HAL9 has a paralog, TBS1, that arose from the whole genome duplication response to salt stress|positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding mitochondrion|nucleus
YNL315C YNL315C ATP11 hom Verified 0.901848171225962 0.183568763291922 no 902 0.186273394143251 660 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase mitochondrion organization|mitochondrial proton-transporting ATP synthase complex assembly unfolded protein binding mitochondrion|mitochondrial matrix
YOR188W YOR188W MSB1 hom Verified 0.901396097925517 0.183688877684986 no 903 0.224333071317307 828 NA FT MITOCHONDRION|SITE OF POLARIZED GROWTH Protein of unknown function; may be involved in positive regulation of 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4; potential Cdc28p substrate; relocalizes from bud neck to cytoplasm upon DNA replication stress establishment of cell polarity molecular_function mitochondrion|cellular bud neck|cellular bud tip
YPR077C_d YPR077C YPR077C hom Dubious 0.901355360121583 0.183699703990509 no 904 0.185993688249075 627 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression increased by deletion of NAP1 Unknown Unknown Unknown
YLR294C_d YLR294C YLR294C hom Dubious 0.900825758797165 0.1838404847625 no 905 0.188177292799658 634 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ATP14 Unknown Unknown Unknown
YGL180W YGL180W ATG1 hom Verified 0.900779002334268 0.183852916982532 no 906 0.175075998176947 591 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Protein ser/thr kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for phagophore assembly site formation; during autophagy forms a complex with Atg13p and Atg17p piecemeal microautophagy of nucleus|mitochondrion degradation|protein phosphorylation|CVT pathway|autophagic vacuole assembly protein serine/threonine kinase activity|protein kinase activity cytosol|pre-autophagosomal structure|Atg1p signaling complex
YLR134W YLR134W PDC5 hom Verified 0.900632559907033 0.183891858399104 no 907 0.177305672698731 599 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Minor isoform of pyruvate decarboxylase, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde, regulation is glucose- and ethanol-dependent, repressed by thiamine, involved in amino acid catabolism L-phenylalanine catabolic process|glucose catabolic process to ethanol|pyruvate metabolic process|tryptophan catabolic process|aromatic amino acid family catabolic process to alcohol via Ehrlich pathway pyruvate decarboxylase activity nucleus|cytoplasm
YKR033C_d YKR033C YKR033C hom Dubious 0.899696026754405 0.184141019207332 no 908 0.184259163314905 593 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene DAL80 Unknown Unknown Unknown
YFR017C YFR017C IGD1 hom Verified 0.899532721239716 0.184184487476406 no 909 0.186753592620341 614 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Cytoplasmic protein that inhibits Gdb1p glycogen debranching activity; required for normal intracellular accumulation of glycogen; phosphorylated in vivo; expression increases during wine fermentation; protein abundance increases in response to DNA replication stress; IGD1 has a paralog, YOL024W, that arose from the whole genome duplication negative regulation of glycogen catabolic process enzyme inhibitor activity cytoplasm
YOR360C YOR360C PDE2 hom Verified 0.898757843281256 0.184390829662182 no 910 0.206819206808933 672 NA FT SIGNALING NUCLEUS High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon cAMP-mediated signaling 3',5'-cyclic-AMP phosphodiesterase activity nucleus|cytoplasm
YDR368W YDR368W YPR1 hom Verified 0.896969673222903 0.184867549911261 no 911 0.181028845048998 621 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS NUCLEUS NADPH-dependent aldo-keto reductase; reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases; protein abundance increases in response to DNA replication stress; YPR1 has a paralog, GCY1, that arose from the whole genome duplication cellular response to oxidative stress|D-xylose catabolic process|arabinose catabolic process glucose 1-dehydrogenase (NADP+) activity|alditol:NADP+ 1-oxidoreductase activity|carbonyl reductase (NADPH) activity nucleus|cytoplasm
YOL111C YOL111C MDY2 hom Verified 0.896830308992324 0.184904736104372 no 912 0.221617436940728 793 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION NUCLEUS Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Get4p; required for efficient mating; involved in shmoo formation and nuclear migration in the pre-zygote; associates with ribosomes protein insertion into ER membrane|cell morphogenesis involved in conjugation with cellular fusion|posttranslational protein targeting to membrane molecular_function ribosome|TRC complex|nucleus|cytoplasm
YGR112W YGR112W SHY1 hom Verified 0.896352999186574 0.185032130650841 no 913 0.154559924350537 523 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome mitochondrial respiratory chain complex IV assembly|aerobic respiration unfolded protein binding mitochondrion|integral to membrane|mitochondrial inner membrane
YNL334C YNL334C SNO2 hom Verified 0.896043590018691 0.185114741444287 no 914 0.187730426999916 644 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Protein of unknown function, nearly identical to Sno3p; expression is induced before the diauxic shift and also in the absence of thiamin pyridoxine metabolic process|thiamine biosynthetic process molecular_function cellular_component
YML004C YML004C GLO1 hom Verified 0.894695416535028 0.185474964759205 no 915 0.18902807652111 632 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Monomeric glyoxalase I, catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione; expression regulated by methylglyoxal levels and osmotic stress methylglyoxal catabolic process to D-lactate|glutathione metabolic process lactoylglutathione lyase activity nucleus|cytoplasm
YDR520C_p YDR520C URC2 hom Uncharacterized 0.89432852487682 0.185573071122321 no 916 0.221462292834737 700 NA FT TRANSCRIPTION FROM RNA POL II|NUCLEOTIDE METABOLISM NUCLEUS Putative Zn(II)2Cys6 motif containing transcription factor; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; similar to S. kluyveri Urc2p involved in uracil catabolism uracil catabolic process sequence-specific DNA binding nucleus|cytoplasm
YIR027C YIR027C DAL1 hom Verified 0.892552360856056 0.186048470288562 no 917 0.201181480932031 677 NA Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression allantoin assimilation pathway allantoinase activity cellular_component
YDR452W YDR452W PPN1 hom Verified 0.892098286855833 0.186170126533609 no 918 0.232157003653924 689 NA FT NUCLEUS Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress polyphosphate catabolic process|polyphosphate metabolic process endopolyphosphatase activity|exopolyphosphatase activity fungal-type vacuole membrane|nucleus
YEL005C YEL005C VAB2 hom Verified 0.892016897808783 0.18619193762892 no 919 0.1840840950292 621 NA Protein with a potential role in vacuolar function, as suggested by its ability to bind Vac8p; likely member of BLOC complex involved in endosomal cargo sorting; Vab2p-GFP-fusion localizes to cytoplasm in punctate patter biological_process molecular_function cytoplasm
YGL170C YGL170C SPO74 hom Verified 0.889014328203679 0.186997689704464 no 920 0.190355157439214 646 NA FT NUCLEUS|CYTOSKELETON Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation ascospore formation structural molecule activity spindle pole body
YNL264C YNL264C PDR17 hom Verified 0.887877288305534 0.187303381399717 no 921 0.190771575531037 666 NA FT LIPID METABOLISM Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition Golgi to plasma membrane protein transport|phosphatidylserine metabolic process|response to drug|sterol biosynthetic process|Unknown|phospholipid transport|phospholipid biosynthetic process phosphatidylinositol transporter activity|phosphatidylcholine transporter activity endosome|cell periphery|cytosol|cytoplasm
YOR030W YOR030W DFG16 hom Verified 0.886550410150749 0.187660501254854 no 922 0.224031098578171 809 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS Probable multiple transmembrane protein; involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; is glycosylated and phosphorylated; interacts with Rim21p and Rim9p in the plasma membrane to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; required for accumulation of processed Rim101p pseudohyphal growth|protein processing molecular_function integral to membrane
YDR115W YDR115W YDR115W hom Verified 0.886224628150382 0.187748247449534 no 923 0.187928552456037 624 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Putative mitochondrial ribosomal protein of the large subunit; similar to E. coli L34 ribosomal protein; required for respiratory growth, as are most mitochondrial ribosomal proteins; protein increases in abundance and relocalizes to the plasma membrane upon DNA replication stress mitochondrial translation structural constituent of ribosome mitochondrial large ribosomal subunit
YKR089C YKR089C TGL4 hom Verified 0.885332354796518 0.187988702273034 no 924 0.187399587421493 631 NA FT LIPID METABOLISM|CELL DIVISION Multifunctional triacylglycerol lipase, steryl ester hydrolase, and Ca2+-independent phospholipase A2; catalyzes acyl-CoA dependent acylation of LPA to PA; required with Tgl3p for timely bud formation; phosphorylated and activated by Cdc28p phospholipid metabolic process|triglyceride catabolic process|triglyceride mobilization|cell budding lysophosphatidic acid acyltransferase activity|triglyceride lipase activity|calcium-independent phospholipase A2 activity|sterol esterase activity lipid particle
YHL007C YHL007C STE20 hom Verified 0.884752471576586 0.1881450743327 no 925 0.194624947015236 690 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|SIGNALING|CELL DIVISION|PROTEIN PHOSPHORYLATION NUCLEUS|SITE OF POLARIZED GROWTH Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p negative regulation of gene expression|osmosensory signaling pathway via Sho1 osmosensor|activation of MAPKKK activity|vacuole inheritance|protein phosphorylation|cellular bud site selection|cellular response to heat|regulation of exit from mitosis|pheromone-dependent signal transduction involved in conjugation with cellular fusion|signal transduction involved in filamentous growth|pseudohyphal growth|sterol import|stress granule assembly|invasive growth in response to glucose limitation|positive regulation of apoptotic process histone serine kinase activity|MAP kinase kinase kinase kinase activity|protein kinase activity incipient cellular bud site|plasma membrane|nucleus|mating projection tip
YCR046C YCR046C IMG1 hom Verified 0.884338783287146 0.188256679097895 no 926 0.194932840210386 672 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit, required for respiration and for maintenance of the mitochondrial genome mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YBL095W_p YBL095W YBL095W hom Uncharacterized 0.883404055037514 0.188509000318559 no 927 0.173836842213859 617 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YNL293W YNL293W MSB3 hom Verified 0.883364863034194 0.18851958438966 no 928 0.188481350583341 641 NA FT VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH Rab GTPase-activating protein; regulates endocytosis via activation of Vps21p and Ypt7p; also acts on Ypt52p and Sec4p; also required for proper actin organization; localizes to the plasma membrane and sites of polarized growth, and a portion localizes to endosomes and vacuoles; similar to Msb4p; relocalizes from bud neck to cytoplasm upon DNA replication stress actin filament organization|exocytosis Rab GTPase activator activity incipient cellular bud site|polarisome|cellular bud tip
YCR076C YCR076C FUB1 hom Verified 0.882688042845139 0.188702422156986 no 929 0.230748922943686 736 NA Putative protein of unknown function; interacts physically with multiple subunits of the 20S proteasome and genetically with genes encoding 20S core particle and 19S regulatory particle subunits; exhibits boundary activity which blocks the propagation of heterochromatic silencing; contains a PI31 proteasome regulator domain and sequence similarity with human PSMF1, a proteasome inhibitor; not an essential gene biological_process proteasome binding cellular_component
YDR315C YDR315C IPK1 hom Verified 0.88265177709057 0.188712222155925 no 930 0.241193255267654 785 NA FT NUCLEUS Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable nuclear-transcribed mRNA catabolic process, non-stop decay|inositol phosphate biosynthetic process inositol pentakisphosphate 2-kinase activity nucleus
YDR497C YDR497C ITR1 hom Verified 0.882260634449749 0.188817939534296 no 931 0.173372573642149 583 NA FT PLASMA MEMBRANE Myo-inositol transporter; has strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p; relative distribution to the vacuole increases upon DNA replication stress myo-inositol transport|transmembrane transport myo-inositol transmembrane transporter activity integral to membrane|plasma membrane|membrane
YKL176C YKL176C LST4 hom Verified 0.881605018341614 0.188995220193913 no 932 0.215437740746127 735 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface intracellular protein transport|vesicle-mediated transport|protein transport|Golgi to plasma membrane transport protein transporter activity vesicle coat
YOR315W YOR315W SFG1 hom Verified 0.881541227536774 0.189012474900233 no 933 0.181216490842965 613 NA FT CELL CYCLE NUCLEUS Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate mitotic cell cycle|pseudohyphal growth molecular_function nucleus|cytoplasm
YFL034C-A YFL034C-A RPL22B hom Verified 0.881146057798828 0.189119385561687 no 934 0.199015872247533 708 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L22B; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22B has a paralog, RPL22A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YHR041C YHR041C SRB2 hom Verified 0.881064575841521 0.189141434617707 no 935 0.238345556780525 815 NA FT TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|RESPONSE TO NUTRIENT LEVELS NUCLEUS RNA POL II, HOLOENZYME Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to chemical stimulus|RNA polymerase II transcriptional preinitiation complex assembly|negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to nutrient levels|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly|core RNA polymerase II binding transcription factor activity|RNA polymerase II transcription factor recruiting transcription factor activity|TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly|protein domain specific binding core mediator complex
YGR262C YGR262C BUD32 hom Verified 0.88104201073103 0.189147541027125 no 936 0.225760763695759 696 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|LIPID METABOLISM|CELL DIVISION|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION NUCLEUS|CHROMOSOME Protein kinase, component of the EKC/KEOPS complex with Kae1p, Cgi121p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription threonylcarbamoyladenosine metabolic process|protein phosphorylation|telomere maintenance|cellular bud site selection|positive regulation of transcription from RNA polymerase II promoter protein serine/threonine kinase activity EKC/KEOPS complex|nucleus|cytoplasm
YPR092W_d YPR092W YPR092W hom Dubious 0.880984274840921 0.189163165655015 no 937 0.199250879221657 667 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YMR199W YMR199W CLN1 hom Verified 0.880957247995044 0.18917047999929 no 938 0.167896625958483 613 NA FT CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION NUCLEUS G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p) regulation of cyclin-dependent protein kinase activity cyclin-dependent protein kinase regulator activity nucleus|cytoplasm
YOL112W YOL112W MSB4 hom Verified 0.880618908502473 0.189262060415649 no 939 0.19183910847237 680 NA FT SIGNALING|NUCLEOTIDE METABOLISM|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH GTPase-activating protein of the Ras superfamily that acts primarily on Sec4p, localizes to the bud site and bud tip, has similarity to Msb3p; msb3 msb4 double mutation causes defects in secretion and actin organization actin filament organization Rab GTPase activator activity incipient cellular bud site|polarisome|cellular bud tip
YDL090C YDL090C RAM1 hom Verified 0.880100649224048 0.189402393735465 no 940 0.256061294646037 887 NA FF|FT PROTEIN PRENYLATION Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit protein farnesylation protein farnesyltransferase activity protein farnesyltransferase complex
YBL070C_d YBL070C YBL070C hom Dubious 0.879813161099868 0.189480266863655 no 941 0.198648186031828 647 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOR237W YOR237W HES1 hom Verified 0.87918243949987 0.189651182116015 no 942 0.202692101022262 657 NA FT VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION Protein implicated in the regulation of ergosterol biosynthesis; one of a seven member gene family with a common essential function and non-essential unique functions; similar to human oxysterol binding protein (OSBP); HES1 has a paralog, KES1, that arose from the whole genome duplication maintenance of cell polarity|endocytosis|exocytosis|sterol transport lipid binding|oxysterol binding|sterol transporter activity cellular_component
YOL101C YOL101C IZH4 hom Verified 0.878137925567153 0.189934436823208 no 943 0.200793687431258 677 NA FT LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family; expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism; protein increases in abundance and relocalizes from nucleus to ER upon DNA replication stress cellular zinc ion homeostasis|cellular lipid metabolic process metal ion binding integral to membrane|membrane
YLR342W YLR342W FKS1 hom Verified 0.877968463584053 0.1899804165866 no 944 0.191921720615373 676 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM MITOCHONDRION|PLASMA MEMBRANE|CYTOSKELETON Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling (1->3)-beta-D-glucan biosynthetic process|positive regulation of endocytosis|regulation of cell size 1,3-beta-D-glucan synthase activity mitochondrion|1,3-beta-D-glucan synthase complex|integral to membrane|plasma membrane|cellular bud neck|cellular bud tip|actin cortical patch
YPL031C YPL031C PHO85 hom Verified 0.877213491899297 0.190185344596069 no 945 0.229307402428618 763 NA FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES A NUCLEUS Cyclin-dependent kinase, with ten cyclin partners; involved in regulating the cellular response to nutrient levels and environmental conditions and progression through the cell cycle regulation of transcription involved in G1/S phase of mitotic cell cycle|negative regulation of calcium-mediated signaling|regulation of protein stability|regulation of protein localization|protein phosphorylation|response to DNA damage stimulus|negative regulation of phosphate metabolic process|fungal-type cell wall organization|regulation of establishment or maintenance of cell polarity|negative regulation of glycogen biosynthetic process|negative regulation of transcription from RNA polymerase II promoter|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of macroautophagy|negative regulation of macroautophagy protein kinase activity|cyclin-dependent protein kinase activity cyclin-dependent protein kinase holoenzyme complex|nucleus
YGR292W YGR292W MAL12 hom Verified 0.87719992055631 0.190189029616612 no 946 0.155595072978619 505 NA FT CARBOHYDRATE METABOLISM Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose sucrose catabolic process|maltose catabolic process sucrose alpha-glucosidase activity|maltose alpha-glucosidase activity plasma membrane
YPR139C YPR139C LOA1 hom Verified 0.877036589901837 0.190233382155371 no 947 0.229527490262694 784 NA FT PROTEIN LOCALIZATION|VACUOLAR TRANSPORT ENDOPLASMIC RETICULUM Lysophosphatidic acid acyltransferase; involved in triacelglyceride homeostasis and lipid droplet formation; localized to lipid droplets and the ER; specificity for oleoyl-CoA lipid particle organization|cellular triglyceride homeostasis|protein targeting to vacuole lysophosphatidic acid acyltransferase activity endoplasmic reticulum|lipid particle|cytoplasm
YOR058C YOR058C ASE1 hom Verified 0.876631447687106 0.190343426197638 no 948 0.156172414044137 556 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION NUCLEUS|CYTOSKELETON Mitotic spindle midzone localized protein; microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate; relative distribution to microtubules decreases upon DNA replication stress cytokinesis, completion of separation|mitotic anaphase B|microtubule bundle formation|spindle pole body separation|spindle midzone assembly|mitotic spindle stabilization|mitotic spindle elongation microtubule binding spindle midzone|nuclear microtubule|spindle
YBL028C YBL028C YBL028C hom Verified 0.87635908611615 0.190417426559126 no 949 0.21361300732089 670 NA FT NUCLEUS Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis biological_process molecular_function ribosome|nucleolus|nucleus|preribosome, large subunit precursor
YDR031W YDR031W MIC14 hom Verified 0.875046857655793 0.190774205254375 no 950 0.170931290254474 518 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS|MITOCHONDRION Mitochondrial intermembrane space protein of unknown function; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress aerobic respiration molecular_function nucleus|mitochondrial intermembrane space|cytoplasm
YDL021W YDL021W GPM2 hom Verified 0.874644433070664 0.190883701660372 no 951 0.197818177071661 663 NA FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event biological_process phosphoglycerate mutase activity|molecular_function cytosol|cytoplasm
YNL203C_d YNL203C YNL203C hom Dubious 0.874635309937834 0.190886184436328 no 952 0.196383704822625 726 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YFR048W YFR048W RMD8 hom Verified 0.872061742059744 0.191587347917992 no 953 0.191417481652268 652 NA FT CELL CYCLE Cytosolic protein required for sporulation biological_process molecular_function cytoplasm
YPR008W YPR008W HAA1 hom Verified 0.870703082015507 0.1919581476184 no 954 0.180205234980934 614 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Transcriptional activator involved in adaptation to weak acid stress; activates transcription of TPO2, YRO2, and other genes encoding membrane stress proteins; HAA1 has a paralog, CUP2, that arose from the whole genome duplication; relocalizes from cytoplasm to nucleus upon DNA replication stress response to acid|positive regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding RNA polymerase II transcription factor activity nucleus
YBR196C-A_p YBR196C-A YBR196C-A hom Uncharacterized 0.870626253174445 0.191979128530764 no 955 0.229221285783051 759 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YFR049W YFR049W YMR31 hom Verified 0.870562812776515 0.191996454299164 no 956 0.215436407503883 729 NA FT TRANSLATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit, has similarity to human mitochondrial ribosomal protein MRP-S36 cytoplasmic translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YOL131W_p YOL131W YOL131W hom Uncharacterized 0.870545187118598 0.192001268090581 no 957 0.190956091153182 684 NA Putative protein of unknown function biological_process molecular_function cellular_component
YOL138C YOL138C RTC1 hom Verified 0.869892736406953 0.192179512650674 no 958 0.194891904044391 675 NA Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; null mutation suppresses cdc13-1 temperature sensitivity; has N-terminal WD-40 repeats and a C-terminal RING motif biological_process molecular_function ribosome|fungal-type vacuole|Seh1-associated complex|extrinsic to fungal-type vacuolar membrane
YPL017C YPL017C IRC15 hom Verified 0.869570093788247 0.192267693548848 no 959 0.224052145688495 767 NA FT PROTEIN LOCALIZATION|CELL CYCLE|OXIDATION-REDUCTION PROCESS|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION CYTOSKELETON Microtubule associated protein; regulates microtubule dynamics; required for accurate meiotic chromosome segregation; null mutant displays large budded cells due to delayed mitotic progression, increased levels of spontaneous Rad52 foci microtubule nucleation|mitotic recombination|microtubule anchoring|meiotic sister chromatid segregation|attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|positive regulation of mitotic cell cycle microtubule binding|S-adenosylmethionine-dependent methyltransferase activity microtubule|cytoplasm
YER173W YER173W RAD24 hom Verified 0.867991326701181 0.192699540383884 no 960 0.201609727136308 641 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein reciprocal meiotic recombination|DNA damage checkpoint|nucleotide-excision repair DNA clamp loader activity Rad17 RFC-like complex|nucleus
YDR370C YDR370C DXO1 hom Verified 0.866817712038327 0.193020947911106 no 961 0.187573454024667 611 NA Protein with decapping and 5′-3′ exoRNase activity; similar to Rai1p biological_process molecular_function cytoplasm
YKL055C YKL055C OAR1 hom Verified 0.866168480171131 0.193198887880164 no 962 0.219287586982659 797 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase, may comprise a type II mitochondrial fatty acid synthase along with Mct1p fatty acid metabolic process|aerobic respiration 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity mitochondrion
YIL024C_p YIL024C YIL024C hom Uncharacterized 0.865672863563656 0.193334792704309 no 963 0.182917750362684 626 NA Putative protein of unknown function; non-essential gene; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p biological_process molecular_function cellular_component
YKR072C YKR072C SIS2 hom Verified 0.865312464995038 0.193433655525386 no 964 0.244275011728565 848 NA FF|FT CELL CYCLE|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM NUCLEUS Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis regulation of mitotic cell cycle|response to salt stress|coenzyme A biosynthetic process phosphopantothenoylcysteine decarboxylase activity|protein phosphatase inhibitor activity phosphopantothenoylcysteine decarboxylase complex|nucleus|cytoplasm
YOR065W YOR065W CYT1 hom Verified 0.865282609435194 0.193441846743632 no 965 0.17490139601835 582 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex oxidative phosphorylation|mitochondrial electron transport, ubiquinol to cytochrome c electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity mitochondrion|mitochondrial respiratory chain|integral to membrane|mitochondrial inner membrane|mitochondrial respiratory chain complex III
YGR110W YGR110W CLD1 hom Verified 0.86451996439715 0.193651158970752 no 966 0.207763284635865 658 NA FT LIPID METABOLISM MITOCHONDRION Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58 cardiolipin acyl-chain remodeling|cardiolipin metabolic process phospholipase A2 activity mitochondrion
YOR386W YOR386W PHR1 hom Verified 0.863086962202193 0.194044827867739 no 967 0.211005511164146 722 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION DNA photolyase involved in photoreactivation, repairs pyrimidine dimers in the presence of visible light; induced by DNA damage; regulated by transcriptional repressor Rph1p photoreactive repair mRNA binding|deoxyribodipyrimidine photo-lyase activity mitochondrion|nucleus
YGR167W YGR167W CLC1 hom Verified 0.862696808968792 0.194152093663865 no 968 0.233168374353948 827 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|GOLGI APPARATUS|PLASMA MEMBRANE Clathrin light chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function; two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component; YGR167W endocytosis|vesicle-mediated transport structural molecule activity clathrin vesicle coat
YOR247W YOR247W SRL1 hom Verified 0.86247193615044 0.194213934910121 no 969 0.199660709634138 647 NA FT CELL WALL ORG/BIOGENESIS SITE OF POLARIZED GROWTH Mannoprotein that exhibits a tight association with the cell wall; required for cell wall stability in the absence of GPI-anchored mannoproteins; has a high serine-threonine content; expression is induced in cell wall mutants; SRL1 has a paralog, SVS1, that arose from the whole genome duplication fungal-type cell wall organization|nucleobase-containing compound metabolic process molecular_function fungal-type cell wall|fungal-type vacuole|cytoplasm|cellular bud tip
YKL194C YKL194C MST1 hom Verified 0.862337100669796 0.194251021152047 no 970 0.236048616771403 793 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(XXX)Q2 in vitro mitochondrial threonyl-tRNA aminoacylation threonine-tRNA ligase activity mitochondrion
YJL102W YJL102W MEF2 hom Verified 0.862063841250474 0.194326193859919 no 971 0.213571511943524 713 NA FT TRANSLATION|NUCLEOTIDE METABOLISM MITOCHONDRION Mitochondrial elongation factor involved in translational elongation translational elongation translation elongation factor activity mitochondrion
YJR110W YJR110W YMR1 hom Verified 0.86190455807949 0.194370020272127 no 972 0.19422333992073 678 NA FT LIPID METABOLISM Phosphatidylinositol 3-phosphate (PI3P) phosphatase; involved in various protein sorting pathways, including CVT targeting and endosome to vacuole transport; has similarity to the conserved myotubularin dual specificity phosphatase family phosphatidylinositol dephosphorylation mRNA binding|phosphatidylinositol-3-phosphatase activity cytoplasm
YLR354C YLR354C TAL1 hom Verified 0.861838816797202 0.19438811059482 no 973 0.226473109749899 741 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS NUCLEUS Transaldolase, enzyme in the non-oxidative pentose phosphate pathway; converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate pentose-phosphate shunt sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity nucleus|cytoplasm
YLR394W YLR394W CST9 hom Verified 0.861672190899487 0.194433966379607 no 974 0.191789368264121 628 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME SUMO E3 ligase; required for synaptonemal complex formation; localizes to synapsis initiation sites on meiotic chromosomes; potential Cdc28p substrate synaptonemal complex assembly|protein sumoylation|synapsis|reciprocal meiotic recombination SUMO ligase activity condensed nuclear chromosome|nuclear chromosome
YHL002W YHL002W HSE1 hom Verified 0.861075754554762 0.194598160834129 no 975 0.20693147977034 642 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes late endosome to vacuole transport|protein targeting to vacuole ubiquitin binding endosome|ESCRT-0 complex
YCR100C_p YCR100C YCR100C hom Uncharacterized 0.860977116698764 0.194625323225009 no 976 0.219087440785772 740 NA Putative protein of unknown function biological_process molecular_function integral to membrane
YML087C YML087C AIM33 hom Verified 0.860725900798258 0.194694512200543 no 977 0.18553687371229 610 NA FT OXIDATION-REDUCTION PROCESS Putative protein of unknown function, highly conserved across species; homolog of human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss; AIM33 has a paralog, PGA3, that arose from the whole genome duplication biological_process molecular_function cellular_component
YML007W YML007W YAP1 hom Verified 0.860145148252839 0.194854518241714 no 978 0.217875711390984 761 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO OXIDATIVE STRESS NUCLEUS Basic leucine zipper (bZIP) transcription factor; required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; Yap1p is degraded in the nucleus after the oxidative stress has passed; mediates resistance to cadmium; YAP1 has a paralog, CAD1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance|response to heat|response to drug|response to singlet oxygen|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|response to metal ion sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nucleus|cytoplasm
YIL084C YIL084C SDS3 hom Verified 0.859759667651366 0.194960768077739 no 979 0.208114907303208 750 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Component of the Rpd3p/Sin3p deacetylase complex required for its structural integrity and catalytic activity, involved in transcriptional silencing and required for sporulation; cells defective in SDS3 display pleiotropic phenotypes positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of chromatin silencing at telomere|chromatin silencing|negative regulation of chromatin silencing at rDNA|positive regulation of transcription from RNA polymerase II promoter|histone deacetylation histone deacetylase activity Rpd3L-Expanded complex|Rpd3L complex
YOR101W YOR101W RAS1 hom Verified 0.859714877875861 0.194973115746312 no 980 0.159943544210006 594 NA FT SIGNALING|NUCLEOTIDE METABOLISM PLASMA MEMBRANE GTPase involved in G-protein signaling in adenylate cyclase activation; plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes; relative distribution to the nucleus increases upon DNA replication stress adenylate cyclase-activating G-protein coupled receptor signaling pathway|replicative cell aging|Ras protein signal transduction GTPase activity plasma membrane
YLL047W_d YLL047W YLL047W hom Dubious 0.859703454662338 0.194976264979846 no 981 0.207863744070991 712 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RNP1 Unknown Unknown Unknown
YBR092C YBR092C PHO3 hom Verified 0.859393426903054 0.195061747468531 no 982 0.177126152530978 627 NA Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin phosphate-containing compound metabolic process|thiamine-containing compound metabolic process acid phosphatase activity cell wall-bounded periplasmic space
YLR247C YLR247C IRC20 hom Verified 0.859083059605197 0.195147346392647 no 983 0.166598553442806 600 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION Putative helicase; localizes to the mitochondrion and the nucleus; YLR247C is not an essential gene; null mutant displays increased levels of spontaneous Rad52p foci double-strand break repair via synthesis-dependent strand annealing helicase activity mitochondrion|nucleus
YOR185C YOR185C GSP2 hom Verified 0.858913974778263 0.195193989388042 no 984 0.214338417436441 729 NA FT PROTEIN LOCALIZATION|SIGNALING|NUCLEOTIDE METABOLISM NUCLEUS GTP binding protein (mammalian Ranp homolog); involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas); Gsp1p homolog that is not required for viability; protein abundance increases in response to DNA replication stress nucleus organization GTPase activity integral to membrane|nucleus
YLR019W YLR019W PSR2 hom Verified 0.858595059450115 0.195281982403709 no 985 0.194136376063134 645 NA FT PLASMA MEMBRANE Functionally redundant Psr1p homolog, a plasma membrane phosphatase involved in the general stress response; required with Psr1p and Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p response to stress phosphoprotein phosphatase activity plasma membrane
YJL077W-B_p YJL077W-B YJL077W-B hom Uncharacterized 0.857729366708196 0.195520960120097 no 986 0.243365461246053 799 NA Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YGR283C YGR283C YGR283C hom Verified 0.857382003645672 0.195616900898697 no 987 0.190746290879165 676 NA FT NUCLEUS Putative S-adenosylmethionine-dependent methyltransferase; may interact with ribosomes, based on co-purification experiments; predicted to be involved in ribosome biogenesis; null mutant is resistant to fluconazole; GFP-fusion protein localizes to the nucleolus biological_process S-adenosylmethionine-dependent methyltransferase activity ribosome|nucleolus
YLR191W YLR191W PEX13 hom Verified 0.857354215692229 0.195624577094041 no 988 0.20686693137459 734 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PEROXISOME ORGANIZATION Integral peroxisomal membrane protein required for translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p protein import into peroxisome matrix, docking protein binding, bridging peroxisomal membrane
YGR157W YGR157W CHO2 hom Verified 0.857208851794635 0.195664735664942 no 989 0.203419882090178 655 NA FT LIPID METABOLISM Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis phosphatidylcholine biosynthetic process phosphatidylethanolamine N-methyltransferase activity integral to membrane|endoplasmic reticulum
YOR036W YOR036W PEP12 hom Verified 0.856822151987344 0.195771590622727 no 990 0.237693620961398 835 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT GOLGI APPARATUS Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin Golgi to vacuole transport|vacuole inheritance SNAP receptor activity endosome|Golgi apparatus
YBL011W YBL011W SCT1 hom Verified 0.856429984761505 0.195879992531768 no 991 0.193573778917877 699 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase of the glycerolipid biosynthesis pathway, prefers 16-carbon fatty acids, similar to Gpt2p, gene is constitutively transcribed phospholipid biosynthetic process glycerol-3-phosphate O-acyltransferase activity|glycerone-phosphate O-acyltransferase activity integral to membrane|endoplasmic reticulum
YBR298C YBR298C MAL31 hom Verified 0.855814641164884 0.196050157702975 no 992 0.219348364827879 771 NA FT CARBOHYDRATE METABOLISM Maltose permease, high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL3 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; functional in genomic reference strain S288C alpha-glucoside transport|transmembrane transport alpha-glucoside:hydrogen symporter activity integral to membrane|membrane
YOR331C_d YOR331C YOR331C hom Dubious 0.855534145676198 0.196127754781132 no 993 0.247070178020443 827 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene VMA4/YOR332W Unknown Unknown Unknown
YBR278W YBR278W DPB3 hom Verified 0.855247647422159 0.196207031707104 no 994 0.203713934041853 678 NA FT RESPONSE TO DNA DAMAGE|GENE SILENCING NUCLEUS|CHROMOSOME Third-largest subunit of DNA polymerase II (DNA polymerase epsilon); required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; mRNA abundance peaks at the G1/S boundary of the cell cycle; DPB3 has a paralog, DLS1, that arose from the whole genome duplication DNA-dependent DNA replication|chromatin silencing at telomere double-stranded DNA binding|single-stranded DNA binding|DNA-directed DNA polymerase activity epsilon DNA polymerase complex
YBL008W YBL008W HIR1 hom Verified 0.855105363438934 0.196246410325206 no 995 0.205808113734174 662 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores DNA replication-independent nucleosome assembly|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter nucleosome binding|transcription corepressor activity|DNA binding chromosome, centromeric region|HIR complex|nucleus
YHR044C YHR044C DOG1 hom Verified 0.854355655227408 0.196453979242948 no 996 0.174524997334285 599 NA FT CARBOHYDRATE METABOLISM 2-deoxyglucose-6-phosphate phosphatase; paralogous to DOG2; member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed, in vivo substrate has not yet been identified glucose metabolic process 2-deoxyglucose-6-phosphatase activity cellular_component
YGR066C_p YGR066C YGR066C hom Uncharacterized 0.854219540419211 0.196491679108351 no 997 0.214497347144051 686 NA Putative protein of unknown function biological_process molecular_function cellular_component
YGL197W YGL197W MDS3 hom Verified 0.853841745340937 0.196596340387555 no 998 0.223091996981889 736 NA FT CELL CYCLE|SIGNALING MITOCHONDRION Putative component of the TOR regulatory pathway; negative regulator of early meiotic gene expression; required, with Pmd1p, for growth under alkaline conditions; has an N-terminal kelch-like domain TOR signaling cascade|negative regulation of sporulation resulting in formation of a cellular spore molecular_function mitochondrion|cytoplasm
YOR325W_d YOR325W YOR325W hom Dubious 0.852798806583015 0.196885442930146 no 999 0.199656706174798 698 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF FRT1 Unknown Unknown Unknown
YKL121W_p YKL121W DGR2 hom Uncharacterized 0.851799204159264 0.197162774080778 no 1000 0.199429325902112 662 NA Protein of unknown function; null mutant is resistant to 2-deoxy-D-glucose and displays abnormally elongated buds biological_process molecular_function cellular_component
YBR228W YBR228W SLX1 hom Verified 0.851569195585388 0.197226621429877 no 1001 0.204769356888355 727 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Subunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p DNA-dependent DNA replication 5'-flap endonuclease activity Slx1-Slx4 complex|nucleus
YNL024C_p YNL024C YNL024C hom Uncharacterized 0.851428045086467 0.197265809140994 no 1002 0.198765081516303 682 NA Putative methyltransferase; has seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; despite similarity to methyltransferases, null mutant does not display alterations in lysine methylation pattern biological_process S-adenosylmethionine-dependent methyltransferase activity cytoplasm
YGL058W YGL058W RAD6 hom Verified 0.849619002733664 0.197768471753273 no 1003 0.205992752968399 711 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEOLYSIS|GENE SILENCING NUCLEUS|CHROMOSOME Ubiquitin-conjugating enzyme (E2), involved in postreplication repair (as a heterodimer with Rad18p), DSBR and checkpoint control (as a heterodimer with Bre1p), ubiquitin-mediated N-end rule protein degradation (as a heterodimer with Ubr1p protein ubiquitination involved in ubiquitin-dependent protein catabolic process|histone monoubiquitination|protein monoubiquitination|error-free translesion synthesis|error-prone translesion synthesis|transcription from RNA polymerase II promoter|mitotic cell cycle G1/S transition DNA damage checkpoint|regulation of dipeptide transport|meiotic DNA double-strand break formation|ubiquitin-dependent protein catabolic process via the N-end rule pathway|double-strand break repair via homologous recombination|protein polyubiquitination|error-free postreplication DNA repair|chromatin silencing at telomere ubiquitin-protein ligase activity nuclear chromatin|proteasome complex|nucleus|cytoplasm
YIL035C YIL035C CKA1 hom Verified 0.849413815241113 0.197825534219169 no 1004 0.201775873303175 705 NA FT RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION NUCLEUS Alpha catalytic subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; regulates Fkh1p-mediated donor preference during mating-type switching regulation of transcription from RNA polymerase I promoter|protein phosphorylation|regulation of transcription from RNA polymerase III promoter|response to DNA damage stimulus protein serine/threonine kinase activity|protein kinase activity protein kinase CK2 complex|UTP-C complex
YLL009C YLL009C COX17 hom Verified 0.84920597119593 0.197883345610299 no 1005 0.18524801190028 588 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS MITOCHONDRION Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs mitochondrial respiratory chain complex IV assembly|intracellular copper ion transport copper chaperone activity cytosol|mitochondrion|mitochondrial intermembrane space
YGL242C_p YGL242C YGL242C hom Uncharacterized 0.849031467734915 0.197931891267559 no 1006 0.220562639703127 732 NA Putative protein of unknown function; deletion mutant is viable biological_process molecular_function cellular_component
YDL049C YDL049C KNH1 hom Verified 0.848826337514173 0.197988966275186 no 1007 0.184990385189839 609 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance (1->6)-beta-D-glucan biosynthetic process molecular_function fungal-type cell wall|extracellular region
YLR087C YLR087C CSF1 hom Verified 0.848480030377663 0.198085344607822 no 1008 0.267887462392964 936 NA FF|FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies fermentation molecular_function mitochondrion
YMR245W_d YMR245W YMR245W hom Dubious 0.847864893657507 0.198256608869236 no 1009 0.250094837389107 862 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR348C YLR348C DIC1 hom Verified 0.847438921056854 0.198375259062665 no 1010 0.18838114898433 627 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix dicarboxylic acid transport dicarboxylic acid transmembrane transporter activity mitochondrial envelope|mitochondrion|integral to membrane
YKR069W YKR069W MET1 hom Verified 0.847134932250814 0.19845995814575 no 1011 0.199158895852591 683 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis siroheme biosynthetic process|methionine biosynthetic process|sulfate assimilation uroporphyrin-III C-methyltransferase activity intracellular
YJL121C YJL121C RPE1 hom Verified 0.847033851769732 0.198488126594841 no 1012 0.224678559685195 770 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress pentose-phosphate shunt ribulose-phosphate 3-epimerase activity cytosol
YKL114C YKL114C APN1 hom Verified 0.845035454161061 0.199045522096748 no 1013 0.255954958337711 891 NA FF|FT RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine base-excision repair 3'-tyrosyl-DNA phosphodiesterase activity|DNA-(apurinic or apyrimidinic site) lyase activity|double-stranded DNA specific 3'-5' exodeoxyribonuclease activity|phosphoric diester hydrolase activity mitochondrion|nucleus
YGR223C YGR223C HSV2 hom Verified 0.844295878128095 0.199252044420123 no 1014 0.205863584772944 700 NA FT MEMBRANE ORGANIZATION|RESPONSE TO NUTRIENT LEVELS Phosphatidylinositol 3,5-bisphosphate-binding protein, plays a role in micronucleophagy; belongs to the PROPPIN family of proteins; predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization piecemeal microautophagy of nucleus phosphatidylinositol binding endosome|fungal-type vacuole|extrinsic to membrane|cytoplasm
YBL002W YBL002W HTB2 hom Verified 0.843625453193492 0.19943936816967 no 1015 0.173547683800825 582 NA FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB1; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation chromatin assembly or disassembly DNA binding replication fork protection complex|nuclear nucleosome
YBR213W YBR213W MET8 hom Verified 0.843452104074113 0.199487820974263 no 1016 0.219920448967213 736 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM Bifunctional dehydrogenase and ferrochelatase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis siroheme biosynthetic process|sulfate assimilation precorrin-2 dehydrogenase activity|ferrochelatase activity cellular_component
YOR011W YOR011W AUS1 hom Verified 0.843095151988811 0.199587614949919 no 1017 0.213954174353911 740 NA FT NUCLEOTIDE METABOLISM MITOCHONDRION|PLASMA MEMBRANE Plasma membrane sterol transporter of the ATP-binding cassette family; required, along with Pdr11p, for uptake of exogenous sterols and their incorporation into the plasma membrane; activity is stimulated by phosphatidylserine; sterol uptake is required for anaerobic growth because sterol biosynthesis requires oxygen sterol import sterol-transporting ATPase activity mitochondrion|integral to membrane|plasma membrane
YIL060W_p YIL060W YIL060W hom Uncharacterized 0.843013069220169 0.199610567280045 no 1018 0.22098071020808 784 NA Putative protein of unknown function; mutant accumulates less glycogen than does wild type; null mutation results in a decrease in plasma membrane electron transport; YIL060W is not an essential gene biological_process molecular_function cellular_component
YOR220W YOR220W RCN2 hom Verified 0.841881493348531 0.199927145153596 no 1019 0.191998083628815 650 NA Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; phosphorylated in response to alpha factor; protein abundance increases in response to DNA replication stress biological_process molecular_function cytoplasm
YML021C YML021C UNG1 hom Verified 0.841819637982508 0.199944458958125 no 1020 0.199471274923157 721 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION Uracil-DNA glycosylase, required for repair of uracil in DNA formed by spontaneous cytosine deamination, not required for strand-specific mismatch repair, cell-cycle regulated, expressed in late G1, localizes to mitochondria and nucleus DNA repair uracil DNA N-glycosylase activity mitochondrion|nucleus
YGR159C YGR159C NSR1 hom Verified 0.841503383894787 0.200032995058409 no 1021 0.21395040266346 671 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS|MITOCHONDRION Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis ribosomal small subunit assembly|rRNA processing single-stranded DNA binding|RNA binding mitochondrion|nucleolus|nucleus
YDR213W YDR213W UPC2 hom Verified 0.840579998657272 0.200291633838302 no 1022 0.210379613379641 733 NA FT TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM NUCLEUS Sterol regulatory element binding protein; induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; relocates from intracellular membranes to perinuclear foci on sterol depletion; UPC2 has a paralog, ECM22, that arose from the whole genome duplication cellular response to hypoxia|positive regulation of ergosterol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus|membrane|cytoplasm|perinuclear region of cytoplasm
YGR064W_d YGR064W YGR064W hom Dubious 0.840468652506595 0.200322835293018 no 1023 0.289662358812452 980 NA FF Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SPT4/YGR063C Unknown Unknown Unknown
YGR150C YGR150C CCM1 hom Verified 0.840154838296186 0.200410788125394 no 1024 0.220328776976489 744 NA FT RNA PROCESSING|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial 15s rRNA-binding protein; required for intron removal of COB and COX1 pre-mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport rRNA metabolic process|mitochondrial RNA processing|mitochondrial genome maintenance rRNA binding mitochondrion
YMR209C_p YMR209C YMR209C hom Uncharacterized 0.840011058325317 0.200451093141787 no 1025 0.201723127177172 703 NA Putative S-adenosylmethionine-dependent methyltransferase; YMR209C is not an essential gene biological_process S-adenosylmethionine-dependent methyltransferase activity cellular_component
YLR098C YLR098C CHA4 hom Verified 0.839508070010033 0.200592131280434 no 1026 0.20794089281556 674 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS DNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain positive regulation of transcription, DNA-dependent|cellular amino acid catabolic process sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nucleus
YDR181C YDR181C SAS4 hom Verified 0.839189033102588 0.200681620240232 no 1027 0.242169355171095 820 NA FT CHROMATIN ORGANIZATION|PROTEOLYSIS|GENE SILENCING NUCLEUS|CHROMOSOME HISTONE ACETYLTRANSFERASE Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p chromatin silencing at telomere acetyltransferase activity|histone acetyltransferase activity nuclear chromatin|SAS acetyltransferase complex|nuclear chromosome, telomeric region
YDR061W_p YDR061W YDR061W hom Uncharacterized 0.838543995208492 0.200862624761978 no 1028 0.206636252228198 661 NA FT NUCLEOTIDE METABOLISM MITOCHONDRION Protein with similarity to ATP-binding cassette (ABC) transporter family members; lacks predicted membrane-spanning regions; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance biological_process molecular_function mitochondrion
YLR324W YLR324W PEX30 hom Verified 0.836393413714779 0.201466808310779 no 1029 0.233848265747393 807 NA FF|FT PEROXISOME ORGANIZATION Peroxisomal integral membrane protein, involved in negative regulation of peroxisome number; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p peroxisome organization molecular_function integral to membrane|peroxisome|integral to peroxisomal membrane
YDR108W YDR108W TRS85 hom Verified 0.836222269708142 0.20151493617993 no 1030 0.244772572829363 844 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION GOLGI APPARATUS Subunit of TRAPPIII (transport protein particle), a multimeric guanine nucleotide-exchange factor for Ypt1p, required for membrane expansion during autophagy and the CVT pathway; directs Ypt1p to the PAS; late post-replication meiotic role meiosis|vesicle organization|piecemeal microautophagy of nucleus|ER to Golgi vesicle-mediated transport|peroxisome degradation|macroautophagy|protein localization to pre-autophagosomal structure|CVT pathway molecular_function TRAPP complex|pre-autophagosomal structure
YJR050W YJR050W ISY1 hom Verified 0.835784235352056 0.201638148382265 no 1031 0.224656336808994 746 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING NUCLEUS Member of NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of spliceosome containing U2, U5, and U6 snRNAs, interacts with Prp16p to modulate splicing fidelity; isy1 syf2 cells have defective spindles generation of catalytic spliceosome for second transesterification step|mRNA 3'-splice site recognition first spliceosomal transesterification activity|second spliceosomal transesterification activity post-spliceosomal complex|Prp19 complex|post-mRNA release spliceosomal complex|U2-type catalytic step 2 spliceosome|U2-type catalytic step 1 spliceosome
YGL060W YGL060W YBP2 hom Verified 0.835299314033245 0.201774601771258 no 1032 0.206908239456221 769 NA FT CELL CYCLE NUCLEUS|CHROMOSOME KINETOCHORE Central kinetochore associated protein; mediates mitotic progression; interacts with several central kinetochore proteins and centromeric histone Cse4p; role in resistance to oxidative stress; similar to Slk19p; YBP2 has a paralog, YBP1, that arose from the whole genome duplication G2/M transition of mitotic cell cycle molecular_function condensed nuclear chromosome kinetochore|centromere-specific nucleosome|cytoplasm
YLL054C_p YLL054C YLL054C hom Uncharacterized 0.835065101759944 0.201840527228032 no 1033 0.207701787709844 674 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene biological_process sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity cellular_component
YNL300W_p YNL300W TOS6 hom Uncharacterized 0.834533313622408 0.201990261436223 no 1034 0.220618516588105 767 NA Glycosylphosphatidylinositol-dependent cell wall protein, expression is periodic and decreases in respone to ergosterol perturbation or upon entry into stationary phase; depletion increases resistance to lactic acid biological_process molecular_function fungal-type cell wall
YOR186W_p YOR186W YOR186W hom Uncharacterized 0.834483450141806 0.202004304775776 no 1035 0.190249180412413 661 NA Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent; YOR186W has a paralog, YLR297W, that arose from the whole genome duplication biological_process molecular_function cellular_component
YNL173C YNL173C MDG1 hom Verified 0.833898953243672 0.20216896357609 no 1036 0.218089553467672 755 NA FT SIGNALING PLASMA MEMBRANE Plasma membrane protein involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations pheromone-dependent signal transduction involved in conjugation with cellular fusion molecular_function membrane raft|plasma membrane
YDR089W YDR089W YDR089W hom Verified 0.833102153243686 0.202393559653831 no 1037 0.169464589279178 578 NA FT MEMBRANE ORGANIZATION Protein of unknown function; deletion confers resistance to nickel; contains an SPX domain, which is found in proteins involved in phosphate homeostasis; relocalizes from vacuole to cytoplasm upon DNA replication stress cellular membrane organization molecular_function integral to membrane|membrane
YDR287W YDR287W INM2 hom Verified 0.832775750669244 0.202485606654831 no 1038 0.204685342173242 689 NA FT LIPID METABOLISM|CARBOHYDRATE METABOLISM Inositol monophosphatase, involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy inositol phosphate dephosphorylation inositol monophosphate 1-phosphatase activity cellular_component
YBR293W YBR293W VBA2 hom Verified 0.832125602957009 0.202669025807114 no 1039 0.201454397928029 727 NA Permease of basic amino acids in the vacuolar membrane basic amino acid transport|transmembrane transport basic amino acid transmembrane transporter activity|drug transmembrane transporter activity fungal-type vacuole membrane|integral to membrane
YDR007W YDR007W TRP1 hom Verified 0.831510519451836 0.202842644045723 no 1040 0.34798694313926 1223 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA) tryptophan biosynthetic process phosphoribosylanthranilate isomerase activity cytoplasm
YJL201W YJL201W ECM25 hom Verified 0.830652326287237 0.203085032712601 no 1041 0.209914327494869 727 NA FT SIGNALING|CELL WALL ORG/BIOGENESIS Non-essential protein of unknown function; promoter contains a consensus binding sequence for factor Abf1p fungal-type cell wall organization|filamentous growth molecular_function cytoplasm
YNL001W YNL001W DOM34 hom Verified 0.830260145364347 0.203195858108875 no 1042 0.214111564098541 727 NA FT CELL CYCLE|TRANSLATION|CELL DIVISION Protein that facilitates ribosomal subunit dissociation; acts when translation is stalled, with binding partner Hbs1p; required for RNA cleavage in no-go decay, but reports conflict on endonuclease activity; Pelota ortholog; protein abundance increases in response to DNA replication stress; DOM34 has a paralog, YCL001W-B, that arose from the whole genome duplication nuclear-transcribed mRNA catabolic process, no-go decay|ribosome disassembly|nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay|nonfunctional rRNA decay ribosome binding|endoribonuclease activity cytoplasm
YMR172C-A_d YMR172C-A YMR172C-A hom Dubious 0.82983430180907 0.20331623701334 no 1043 0.200461518427787 700 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YNL080C YNL080C EOS1 hom Verified 0.829783646519451 0.203330559254572 no 1044 0.221719297535159 746 NA FT CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein involved in N-glycosylation; deletion mutation confers sensitivity to exidative stress and shows synthetic lethality with mutations in the spindle checkpoint genes BUB3 and MAD1; YNL080C is not an essential gene cellular response to oxidative stress|protein N-linked glycosylation molecular_function integral to membrane|endoplasmic reticulum membrane
YDR034C YDR034C LYS14 hom Verified 0.829168631439054 0.203504496211628 no 1045 0.206956905778246 678 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer Unknown|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YMR075W YMR075W RCO1 hom Verified 0.829141660150755 0.20351212619177 no 1046 0.209723129777773 741 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p regulation of DNA-dependent DNA replication initiation|negative regulation of antisense RNA transcription|transcription elongation from RNA polymerase II promoter|histone deacetylation molecular_function Rpd3S complex|histone deacetylase complex|nucleus|Rpd3L complex
YKL094W YKL094W YJU3 hom Verified 0.82821113300411 0.203775469996364 no 1047 0.201106606301587 675 NA FT LIPID METABOLISM ENDOPLASMIC RETICULUM|MITOCHONDRION Monoglyceride lipase (MGL), functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family triglyceride metabolic process serine hydrolase activity|acylglycerol lipase activity mitochondrial outer membrane|lipid particle|plasma membrane|membrane|cytoplasm
YGL041C_d YGL041C YGL041C hom Dubious 0.828092892724623 0.203808947122688 no 1048 0.217106617389434 736 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YMR251W YMR251W GTO3 hom Verified 0.827401600725298 0.204004736801893 no 1049 0.215851227357539 734 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Omega class glutathione transferase; putative cytosolic localization glutathione metabolic process glutathione transferase activity cytoplasm
YOL024W_p YOL024W YOL024W hom Uncharacterized 0.82689014598262 0.204149664562754 no 1050 0.19286260869767 656 NA Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site; YOL024W has a paralog, IGD1, that arose from the whole genome duplication biological_process molecular_function cellular_component
YLR435W YLR435W TSR2 hom Verified 0.825016989932322 0.20468097250752 no 1051 0.209217529118921 721 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Protein with a potential role in pre-rRNA processing maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function nucleus|cytoplasm
YPR100W YPR100W MRPL51 hom Verified 0.824442280433211 0.204844149698403 no 1052 0.237955370339439 800 NA FT TRANSLATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation|aerobic respiration structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YFR044C YFR044C DUG1 hom Verified 0.823872763470674 0.205005928862291 no 1053 0.210040902285947 737 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|PROTEOLYSIS MITOCHONDRION Cys-Gly metallo-di-peptidase; forms a complex with Dug2p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p) glutathione catabolic process metallodipeptidase activity|omega peptidase activity mitochondrion|ribosome|cytoplasm
YMR294W-A_d YMR294W-A YMR294W-A hom Dubious 0.822815149248689 0.205306560203173 no 1054 0.22357835445906 734 NA Dubious open reading frame unlikely to encode a functional protein, substantially overlaps YMR295C; deletion causes sensitivity to unfolded protein response-inducing agents Unknown Unknown Unknown
YJR010C-A YJR010C-A SPC1 hom Verified 0.822158001788205 0.20549348900697 no 1055 0.208524239252244 722 NA FT PROTEIN LOCALIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Subunit of the signal peptidase complex (SPC); SPC cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER); homolog of the SPC12 subunit of mammalian signal peptidase complex; protein abundance increases in response to DNA replication stress signal peptide processing|protein targeting to ER molecular_function signal peptidase complex
YIL095W YIL095W PRK1 hom Verified 0.821348966216974 0.205723761865953 no 1056 0.195126640721113 678 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION SITE OF POLARIZED GROWTH|CYTOSKELETON Protein serine/threonine kinase; regulates the organization and function of the actin cytoskeleton and reduces endocytic ability of cell through the phosphorylation of the Pan1p-Sla1p-End3p protein complex; PRK1 has a paralog, ARK1, that arose from the whole genome duplication regulation of endocytosis|actin filament organization|protein phosphorylation|actin cortical patch assembly|cytokinesis protein serine/threonine kinase activity|protein kinase activity mating projection tip|actin cortical patch
YIL093C YIL093C RSM25 hom Verified 0.821083835609705 0.205799258331368 no 1057 0.2209460614804 791 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YPL201C YPL201C YIG1 hom Verified 0.820549215348861 0.205951542496162 no 1058 0.208347565262101 729 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol glycerol biosynthetic process molecular_function cytosol|nucleus
YOR012W_p YOR012W YOR012W hom Uncharacterized 0.819859109080026 0.206148214940341 no 1059 0.155827564833301 526 NA Putative protein of unknown function biological_process molecular_function cellular_component
YNL067W-B_p YNL067W-B YNL067W-B hom Uncharacterized 0.818530870633919 0.206527061055347 no 1060 0.223074534845365 767 NA Putative protein of unknown function biological_process molecular_function cellular_component
YMR030W YMR030W RSF1 hom Verified 0.817844555855897 0.206722976326519 no 1061 0.186766836784952 591 NA FT TRANSCRIPTION FROM RNA POL II|SIGNALING|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS|MITOCHONDRION Protein required for respiratory growth; localized to both the nucleus and mitochondrion; may interact with transcription factors to mediate the transition to respiratory growth and activate transcription of nuclear and mitochondrial genes transcription from mitochondrial promoter|calcium-mediated signaling|transcription from RNA polymerase II promoter|aerobic respiration molecular_function mitochondrion|nucleus
YLR067C YLR067C PET309 hom Verified 0.817298687954666 0.206878878199743 no 1062 0.213777490404259 719 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Specific translational activator for the COX1 mRNA, also influences stability of intron-containing COX1 primary transcripts; localizes to the mitochondrial inner membrane; contains seven pentatricopeptide repeats (PPRs) positive regulation of mitochondrial translational initiation|RNA metabolic process|mitochondrial respiratory chain complex IV biogenesis|aerobic respiration translation regulator activity extrinsic to mitochondrial inner membrane|mitochondrion|integral to membrane|mitochondrial inner membrane
YDR019C YDR019C GCV1 hom Verified 0.817033965915187 0.206954508835105 no 1063 0.221255337935469 789 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION T subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm glycine catabolic process|glycine metabolic process|one-carbon metabolic process glycine dehydrogenase (decarboxylating) activity mitochondrion|glycine cleavage complex
YJL139C YJL139C YUR1 hom Verified 0.816781768109634 0.20702657653522 no 1064 0.211438705803061 762 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Mannosyltransferase involved in protein N-glycosylation; member of the KTR1 family; located in the Golgi apparatus; YUR1 has a paralog, KTR2, that arose from the whole genome duplication cell wall mannoprotein biosynthetic process|protein N-linked glycosylation mannosyltransferase activity Golgi apparatus
YGR269W_d YGR269W YGR269W hom Dubious 0.816652192924008 0.207063609536814 no 1065 0.219150492038329 756 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF HUA1/YGR268C Unknown Unknown Unknown
YDR199W_d YDR199W YDR199W hom Dubious 0.815933819363834 0.207268994078731 no 1066 0.232940945731966 813 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity Unknown Unknown Unknown
YIL008W YIL008W URM1 hom Verified 0.814052889128942 0.20780732640313 no 1067 0.215792537179685 742 NA FT RNA PROCESSING|CELL DIVISION|RESPONSE TO OXIDATIVE STRESS NUCLEUS Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs; receives sulfur from the E1-like enzyme Uba4p and transfers it to tRNA; also functions as a protein tag with roles in nutrient sensing and oxidative stress response cellular response to oxidative stress|tRNA wobble position uridine thiolation|cell budding|protein urmylation|invasive growth in response to glucose limitation|tRNA wobble uridine modification protein tag cytosol|nucleus|cytoplasm
YCL026C-B YCL026C-B HBN1 hom Verified 0.813230719005185 0.208042895035004 no 1068 0.220361932786346 756 NA FT OXIDATION-REDUCTION PROCESS NUCLEUS Protein of unknown function; similar to bacterial nitroreductases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein becomes insoluble upon intracellular iron depletion; protein abundance increases in response to DNA replication stress biological_process NAD(P)H nitroreductase activity nucleus|cytoplasm
YLR311C_d YLR311C YLR311C hom Dubious 0.812458800459076 0.208264208964914 no 1069 0.21500692870413 734 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGR092W YGR092W DBF2 hom Verified 0.811985114348256 0.208400086513002 no 1070 0.282968707891831 973 NA FF|FT CELL CYCLE|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS SITE OF POLARIZED GROWTH|CYTOSKELETON Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; phosphorylates Chs2p to regulate primary septum formation and Hof1p to regulate cytokinesis nuclear division|protein phosphorylation|vacuolar acidification protein serine/threonine kinase activity|protein kinase activity spindle pole body|cellular bud neck
YGL031C YGL031C RPL24A hom Verified 0.81176997663063 0.20846181634173 no 1071 0.218413143818191 761 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L24A; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24A has a paralog, RPL24B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YMR034C_p YMR034C YMR034C hom Uncharacterized 0.811526537793619 0.208531679660726 no 1072 0.217778821016537 694 NA Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene biological_process sterol transporter activity integral to membrane
YPL138C YPL138C SPP1 hom Verified 0.809983714257623 0.208974767918293 no 1073 0.213334340679677 715 NA FT CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS Subunit of COMPASS (Set1C), a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; interacts with Orc2p; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein histone H3-K4 methylation|regulation of transcription, DNA-dependent|chromatin silencing at telomere histone methyltransferase activity (H3-K4 specific)|chromatin binding|methylated histone residue binding Set1C/COMPASS complex
YKL204W YKL204W EAP1 hom Verified 0.809458896798898 0.209125618175551 no 1074 0.238572949197589 809 NA FT TRANSLATION eIF4E-associated protein, competes with eIF4G for binding to eIF4E; accelerates mRNA degradation by promoting decapping, facilitated by interaction with eIF4E; essential for Puf5p mediated repression; associates with Puf5p and Dhh1p; inhibits cap-dependent translation; functions independently of eIF4E to maintain genetic stability; plays a role in cell growth, implicated in the TOR signaling cascade negative regulation of translation eukaryotic initiation factor 4E binding mRNA cap binding complex|cytoplasmic stress granule
YMR304W YMR304W UBP15 hom Verified 0.809339595041959 0.209159918470493 no 1075 0.243335816828291 775 NA FT PROTEOLYSIS Ubiquitin-specific protease involved in protein deubiquitination; catalytic activity regulated by an N-terminal TRAF-like domain and and C-terminal sequences; physically interacts with anaphase-promoting complex/cyclosome (APC/C) activator, Cdh1p; forms a complex with AAA peroxins Pex1p and Pex6p protein deubiquitination ubiquitin-specific protease activity peroxisome|cytoplasm
YLR094C YLR094C GIS3 hom Verified 0.809249548605482 0.209185809799177 no 1076 0.230487333188531 760 NA FT SIGNALING NUCLEUS Protein of unknown function intracellular signal transduction molecular_function nucleus|cytoplasm
YNL055C YNL055C POR1 hom Verified 0.808605907480625 0.209370932848873 no 1077 0.243605985472017 828 NA FT ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS MITOCHONDRION Mitochondrial porin (voltage-dependent anion channel); outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated; protein abundance increases in response to DNA replication stress; POR1 has a paralog, POR2, that arose from the whole genome duplication DNA transport|mitochondrion organization|apoptotic process|ion transport|cell redox homeostasis voltage-gated anion channel activity mitochondrial outer membrane|mitochondrion|integral to mitochondrial outer membrane
YLL043W YLL043W FPS1 hom Verified 0.808209884564252 0.209484884230511 no 1078 0.206491231058974 742 NA FT ION HOMEOSTASIS|CARBOHYDRATE METABOLISM|ION HOMEOSTASIS PLASMA MEMBRANE Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress conjugation with cellular fusion|transport|arsenite transport|glycerol transport|acetate transport|response to arsenic-containing substance glycerol transmembrane transporter activity|transporter activity integral to membrane|plasma membrane|fungal-type vacuole|cytoplasm
YBR182C-A_p YBR182C-A YBR182C-A hom Uncharacterized 0.807537747060963 0.209678368138604 no 1079 0.219985728820914 753 NA Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YDL069C YDL069C CBS1 hom Verified 0.806902475628551 0.209861336210487 no 1080 0.21802839864086 741 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial translational activator of the COB mRNA; membrane protein that interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader mitochondrial respiratory chain complex III biogenesis|positive regulation of mitochondrial translation translation regulator activity extrinsic to mitochondrial inner membrane|mitochondrion|mitochondrial ribosome
YDL123W YDL123W SNA4 hom Verified 0.806790813110296 0.209893506450608 no 1081 0.226912447127567 743 NA Protein of unknown function, localized to the vacuolar outer membrane; predicted to be palmitoylated biological_process molecular_function fungal-type vacuole lumen|fungal-type vacuole membrane
YLR319C YLR319C BUD6 hom Verified 0.8059540288432 0.210134678242216 no 1082 0.223392912760702 698 NA FT CELL CYCLE|CHROMATIN ORGANIZATION|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Actin- and formin-interacting protein; stimulates actin cable nucleation by recruiting actin monomers to Bni1p; involved in polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate bipolar cellular bud site selection|positive regulation of formin-nucleated actin cable assembly|cellular bud site selection|Rho protein signal transduction|extrachromosomal circular DNA localization involved in cell aging|establishment of cell polarity|response to osmotic stress|cytokinesis cytoskeletal regulatory protein binding polarisome|actin cap|spindle pole body|mating projection tip
YPL101W YPL101W ELP4 hom Verified 0.805733250293181 0.210198336537522 no 1083 0.241197393540729 822 NA FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity regulation of transcription from RNA polymerase II promoter|tRNA wobble uridine modification ATPase activity|tRNA binding Elongator holoenzyme complex|cytoplasm
YGR255C YGR255C COQ6 hom Verified 0.80438254361814 0.210588039778454 no 1084 0.214405221558606 761 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM MITOCHONDRION Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS) ubiquinone biosynthetic process N,N-dimethylaniline monooxygenase activity mitochondrion|mitochondrial inner membrane
YJR078W YJR078W BNA2 hom Verified 0.804359175439538 0.210594785648246 no 1085 0.18501585715072 619 NA FT OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for de novo biosynthesis of NAD from tryptophan via kynurenine; interacts genetically with telomere capping gene CDC13; regulated by Hst1p and Aftp de novo NAD biosynthetic process from tryptophan tryptophan 2,3-dioxygenase activity|indoleamine 2,3-dioxygenase activity cytoplasm
YMR237W YMR237W BCH1 hom Verified 0.803668468534446 0.210794234519706 no 1086 0.219289230847063 763 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM GOLGI APPARATUS Member of the ChAPs family (Chs5p-Arf1p-binding proteins); members include Bch1p, Bch2p, Bud7p, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p to mediate export of specific cargo proteins from the Golgi to the plasma membrane; may interact with ribosomes; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress; BCH1 has a paralog, BUD7, that arose from the whole genome duplication Golgi to plasma membrane transport|fungal-type cell wall chitin biosynthetic process molecular_function ribosome|clathrin-coated vesicle|exomer complex
YIL159W YIL159W BNR1 hom Verified 0.803020877886155 0.210981333710775 no 1087 0.205857930969151 709 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNI1 barbed-end actin filament capping|actin filament bundle assembly|formin-nucleated actin cable assembly profilin binding cellular bud neck
YGR275W YGR275W RTT102 hom Verified 0.80165200857386 0.211377141975288 no 1088 0.227746566636071 722 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|CHROMOSOME SEGREGATION NUCLEUS RSC COMPLEX Component of both the SWI/SNF and RSC chromatin remodeling complexes; suggested role in chromosome maintenance; possible weak regulator of Ty1 transposition; protein abundance increases in response to DNA replication stress chromosome segregation|nucleosome disassembly|chromatin remodeling|transcription elongation from RNA polymerase II promoter molecular_function RSC complex|SWI/SNF complex|nucleus
YNL284C YNL284C MRPL10 hom Verified 0.801364290316411 0.211460390927049 no 1089 0.220245481799679 778 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YDR143C YDR143C SAN1 hom Verified 0.800990990294551 0.211568430881089 no 1090 0.211450628289382 663 NA FT PROTEOLYSIS NUCLEUS Ubiquitin-protein ligase; involved in the proteasome-dependent degradation of aberrant nuclear proteins; targets substrates with regions of exposed hydrophobicity containing 5 or more contiguous hydrophobic residues; contains intrinsically disordered regions that contribute to substrate recognition nucleus-associated proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to misfolded protein|response to stress ubiquitin-protein ligase activity nucleus|cytoplasm
YEL059W_d YEL059W HHY1 hom Dubious 0.800479593371191 0.211716491089677 no 1091 0.19635957336804 637 NA Dubious open reading frame unlikely to encode a functional protein; mutant is hypersensitive to hygromycin B indicative of defects in vacuolar trafficking Unknown Unknown Unknown
YGL125W YGL125W MET13 hom Verified 0.79954697249733 0.211986660604285 no 1092 0.223162147135717 711 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION Major isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway methionine biosynthetic process methylenetetrahydrofolate reductase (NADPH) activity mitochondrion
YLR036C_p YLR036C YLR036C hom Uncharacterized 0.799315405875461 0.212053774020557 no 1093 0.198191589802239 695 NA Putative protein of unknown function predicted to have transmembrane domains; interacts with HSP90 by yeast two-hybrid analysis; YLR036C is not an essential protein biological_process molecular_function integral to membrane
YDR069C YDR069C DOA4 hom Verified 0.799158499630214 0.212099256176686 no 1094 0.235546558497202 812 NA FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|PROTEOLYSIS MITOCHONDRION Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole protein deubiquitination|endocytosis|regulation of DNA replication|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|free ubiquitin chain depolymerization|ubiquitin homeostasis|ubiquitin-dependent protein catabolic process endopeptidase activity|ubiquitin-specific protease activity|ubiquitin thiolesterase activity endosome|proteasome complex|mitochondrion
YLL060C YLL060C GTT2 hom Verified 0.798955728889134 0.212158041446891 no 1095 0.205272908813374 727 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p; protein abundance increases in response to DNA replication stress glutathione metabolic process glutathione transferase activity mitochondrion
YGR070W YGR070W ROM1 hom Verified 0.798871281246551 0.212182526474196 no 1096 0.224154876548384 803 NA FT SIGNALING|NUCLEOTIDE METABOLISM GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP small GTPase mediated signal transduction|activation of Rho GTPase activity Rho guanyl-nucleotide exchange factor activity intracellular
YDL010W YDL010W GRX6 hom Verified 0.798481749696033 0.212295489915826 no 1097 0.207900341923793 654 NA FT RESPONSE TO OXIDATIVE STRESS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Cis-golgi localized monothiol glutaredoxin, binds Fe-S cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; GRX6 has a paralog, GRX7, that arose from the whole genome duplication cellular response to oxidative stress glutathione-disulfide reductase activity|iron ion binding|protein homodimerization activity|2 iron, 2 sulfur cluster binding integral to membrane|Golgi apparatus|Golgi lumen|endoplasmic reticulum membrane|fungal-type vacuole|cis-Golgi network
YER073W YER073W ALD5 hom Verified 0.798175862498293 0.212384221279827 no 1098 0.219249564888903 762 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION Mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed acetate biosynthetic process aldehyde dehydrogenase [NAD(P)+] activity mitochondrion
YLR091W YLR091W GEP5 hom Verified 0.797718807221992 0.212516843657907 no 1099 0.238354666043622 801 NA FT MITOCHONDRION ORGANIZATION MITOCHONDRION Protein of unknown function, required for mitochondrial genome maintenance; detected in highly purified mitochondria in high-throughput studies; null mutant has decreased levels of cardiolipin and phosphatidylethanolamine mitochondrial genome maintenance molecular_function mitochondrion
YGR010W YGR010W NMA2 hom Verified 0.797612898122798 0.212547581890213 no 1100 0.219051579746184 679 NA FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM NUCLEUS Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in de novo and salvage synthesis of NAD(+); NMA2 has a paralog, NMA1, that arose from the whole genome duplication NAD biosynthetic process nicotinamide-nucleotide adenylyltransferase activity nucleus
YLR257W YLR257W YLR257W hom Verified 0.797261541295703 0.212649575556254 no 1101 0.210471318588018 700 NA Protein of unknown function; protein abundance increases in response to DNA replication stress biological_process molecular_function cytoplasm
YDR197W YDR197W CBS2 hom Verified 0.796878339072753 0.212760846044366 no 1102 0.242852940997685 811 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial translational activator of the COB mRNA; interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader mitochondrial respiratory chain complex III biogenesis|positive regulation of mitochondrial translation translation regulator activity mitochondrion|extrinsic to mitochondrial inner membrane|mitochondrial ribosome
YML042W YML042W CAT2 hom Verified 0.795945189860109 0.213031946847799 no 1103 0.202955642866405 645 NA FT KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes carnitine metabolic process carnitine O-acetyltransferase activity mitochondrion|peroxisomal matrix|peroxisome
YGR144W YGR144W THI4 hom Verified 0.795799471281198 0.213074299553287 no 1104 0.234811084808468 807 NA FT MITOCHONDRION ORGANIZATION NUCLEUS Thiazole synthase, abundant protein involved in the formation of the thiazole moiety of thiamine during thiamine biosynthesis; acts more as a co-substrate rather than an enzyme by providing the sulphur source for thiazole formation; undergoes a single turnover only; required for mitochondrial genome stability in response to DNA damaging agents thiamine biosynthetic process|mitochondrial genome maintenance|thiazole biosynthetic process ferrous iron binding cytosol
YPR058W YPR058W YMC1 hom Verified 0.795616602570061 0.213127456792352 no 1105 0.200969305728002 643 NA FT MITOCHONDRION Putative mitochondrial inner membrane transporter; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; YMC1 has a paralog, YMC2, that arose from the whole genome duplication mitochondrial transport organic acid transmembrane transporter activity mitochondrion|integral to membrane
YLR084C YLR084C RAX2 hom Verified 0.794300269811011 0.213510323504645 no 1106 0.243392825360146 774 NA FT CELL CYCLE|CELL DIVISION MITOCHONDRION|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p; RAX2 mRNA stability is regulated by Mpt5p cellular bud site selection molecular_function mitochondrion|cellular bud scar|cellular bud neck|membrane
YOL136C YOL136C PFK27 hom Verified 0.794293053932813 0.213512423408953 no 1107 0.197398799207872 697 NA FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY 6-phosphofructo-2-kinase, catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A regulation of glycolysis|fructose 2,6-bisphosphate metabolic process 6-phosphofructo-2-kinase activity cytoplasm
YFR034C YFR034C PHO4 hom Verified 0.793933964551631 0.213616937788179 no 1108 0.249575707350116 866 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS NUCLEUS Basic helix-loop-helix (bHLH) transcription factor of the myc-family; activates transcription cooperatively with Pho2p in response to phosphate limitation; binding to 'CACGTG' motif is regulated by chromatin restriction, competitive binding of Cbf1p to the same DNA binding motif and cooperation with Pho2p,; function is regulated by phosphorylation at multiple sites and by phosphate availability cellular response to phosphate starvation|positive regulation of phosphate metabolic process|phosphate-containing compound metabolic process|chromatin remodeling|positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nucleus|cytoplasm
YOR200W_d YOR200W YOR200W hom Dubious 0.793393538959153 0.21377428695843 no 1109 0.263201402346331 912 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRM1/YOR201c Unknown Unknown Unknown
YHR016C YHR016C YSC84 hom Verified 0.792076360784166 0.214158076399126 no 1110 0.21947687831965 730 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION CYTOSKELETON Actin-binding protein; involved in bundling of actin filaments and endocytosis of actin cortical patches; activity stimulated by Las17p; contains SH3 domain similar to Rvs167p; YSC84 has a paralog, LSB3, that arose from the whole genome duplication endocytosis|actin filament organization|actin filament bundle assembly|actin cortical patch localization|actin cytoskeleton organization actin filament binding actin cortical patch
YHL021C YHL021C AIM17 hom Verified 0.79165584460789 0.214280687608474 no 1111 0.205511627127938 687 NA FT OXIDATION-REDUCTION PROCESS MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss biological_process molecular_function mitochondrion
YEL039C YEL039C CYC7 hom Verified 0.789808446933329 0.214819822615133 no 1112 0.235288822199236 780 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; protein abundance increases in response to DNA replication stress; CYC7 has a paralog, CYC1, that arose from the whole genome duplication mitochondrial electron transport, cytochrome c to oxygen|mitochondrial electron transport, ubiquinol to cytochrome c electron carrier activity mitochondrion|mitochondrial intermembrane space
YKL102C_d YKL102C YKL102C hom Dubious 0.789523316543643 0.214903103741265 no 1113 0.202918790987529 695 NA Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site Unknown Unknown Unknown
YDR234W YDR234W LYS4 hom Verified 0.787258031084848 0.215565416254521 no 1114 0.226178233151185 772 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway lysine biosynthetic process via aminoadipic acid homoaconitate hydratase activity mitochondrion
YPR114W_p YPR114W YPR114W hom Uncharacterized 0.786037764129618 0.215922681651786 no 1115 0.224157227583221 777 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Putative protein of unknown function biological_process molecular_function integral to membrane|endoplasmic reticulum
YER131W YER131W RPS26B hom Verified 0.785710722677766 0.216018489943043 no 1116 0.21857335268889 744 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S26, no bacterial homolog; RPS26B has a paralog, RPS26A, that arose from the whole genome duplication cytoplasmic translation|rRNA export from nucleus structural constituent of ribosome cytosolic small ribosomal subunit
YAL056W YAL056W GPB2 hom Verified 0.785563095149341 0.216061746169695 no 1117 0.210164658938216 696 NA FT TRANSCRIPTION FROM RNA POL II|SIGNALING MITOCHONDRION|PLASMA MEMBRANE Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; GPB2 has a paralog, GPB1, that arose from the whole genome duplication signal transduction|glucose mediated signaling pathway|pseudohyphal growth|ascospore formation|negative regulation of Ras protein signal transduction|invasive growth in response to glucose limitation|positive regulation of transcription from RNA polymerase II promoter cAMP-dependent protein kinase inhibitor activity|signal transducer activity|GTPase activating protein binding mitochondrion|plasma membrane|cytoplasm
YER040W YER040W GLN3 hom Verified 0.785561311375699 0.216062268862491 no 1118 0.20793626336423 729 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS NUCLEUS Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR), localization and activity regulated by quality of nitrogen source nitrogen catabolite activation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity cytosol|nucleus
YMR040W YMR040W YET2 hom Verified 0.784716991425277 0.21630975912128 no 1119 0.227429041591815 715 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein biological_process molecular_function ribosome|integral to membrane
YMR041C YMR041C ARA2 hom Verified 0.784512753899273 0.216369650638333 no 1120 0.207342843843634 648 NA FT OXIDATION-REDUCTION PROCESS NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase dehydro-D-arabinono-1,4-lactone biosynthetic process D-arabinose 1-dehydrogenase [NAD(P)+] activity cellular_component
YOR071C YOR071C NRT1 hom Verified 0.783095458522906 0.216785528936903 no 1121 0.203930227261659 727 NA FT PLASMA MEMBRANE High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity thiamine transport|nicotinamide riboside transport nicotinamide riboside transporter activity integral to membrane|plasma membrane
YHR193C YHR193C EGD2 hom Verified 0.782526190175968 0.21695269989712 no 1122 0.218141152828815 751 NA FT PROTEIN LOCALIZATION NUCLEUS Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes 'de novo' cotranslational protein folding unfolded protein binding|phosphatidic acid binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4-phosphate binding nascent polypeptide-associated complex
YPR095C YPR095C SYT1 hom Verified 0.780095547838213 0.21766731842424 no 1123 0.225431921467897 779 NA FT VESICLE-MEDIATED TRANSPORT|SIGNALING MITOCHONDRION|GOLGI APPARATUS Guanine nucleotide exchange factor (GEF) for Arf proteins; promotes activation of Arl1p, which recruits Imh1p to the Golgi; involved in vesicular transport; member of the Sec7-domain family; contains a PH domain vesicle-mediated transport|exocytosis|positive regulation of ARF protein signal transduction ARF guanyl-nucleotide exchange factor activity mitochondrion|Golgi apparatus part
YGR171C YGR171C MSM1 hom Verified 0.779863301705354 0.21773567072617 no 1124 0.22692244011737 755 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION MITOCHONDRION Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p methionyl-tRNA aminoacylation methionine-tRNA ligase activity mitochondrion
YOL003C YOL003C PFA4 hom Verified 0.779744010805373 0.21777078401448 no 1125 0.219437433851634 755 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases protein palmitoylation palmitoyltransferase activity integral to membrane|endoplasmic reticulum
YLL013C YLL013C PUF3 hom Verified 0.779190086552486 0.217933874467199 no 1126 0.215179414452424 733 NA FT OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|RNA LOCALIZATION MITOCHONDRION Protein of the mitochondrial outer surface, links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process|intracellular mRNA localization|mitochondrion organization|aerobic respiration|mitochondrion localization mRNA binding external side of mitochondrial outer membrane|cytoplasm
YDR272W YDR272W GLO2 hom Verified 0.778857310344105 0.218031886741692 no 1127 0.222069913026071 749 NA FT KETONE METABOLISM|CARBOHYDRATE METABOLISM Cytoplasmic glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate cellular carbohydrate metabolic process|methylglyoxal catabolic process to D-lactate hydroxyacylglutathione hydrolase activity cytoplasm
YBR176W YBR176W ECM31 hom Verified 0.778006641772615 0.218282548857287 no 1128 0.227448637893006 701 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM MITOCHONDRION Ketopantoate hydroxymethyltransferase, required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate pantothenate biosynthetic process 3-methyl-2-oxobutanoate hydroxymethyltransferase activity mitochondrion
YJL179W YJL179W PFD1 hom Verified 0.777487522967284 0.218435596455014 no 1129 0.225572640153092 781 NA FT CYTOSKELETON ORGANIZATION Subunit of heterohexameric prefoldin, which binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin protein folding|cytoskeleton organization unfolded protein binding prefoldin complex
YDL023C_d YDL023C YDL023C hom Dubious 0.777148264191258 0.218535650758989 no 1130 0.230948006897272 789 NA Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance Unknown Unknown Unknown
YLR449W YLR449W FPR4 hom Verified 0.777093687756245 0.218551748921851 no 1131 0.2214107748889 762 NA FT CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones histone peptidyl-prolyl isomerization|negative regulation of histone H3-K36 methylation|regulation of transcription by chromatin organization|chromatin silencing at rDNA|nucleosome assembly peptidyl-prolyl cis-trans isomerase activity|macrolide binding chromatin|nucleus
YDR165W YDR165W TRM82 hom Verified 0.776726279441017 0.218660139450208 no 1132 0.242176631369964 799 NA FT RNA PROCESSING NUCLEUS Catalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p tRNA methylation tRNA (guanine-N7-)-methyltransferase activity tRNA methyltransferase complex|nucleus
YPL223C YPL223C GRE1 hom Verified 0.774630934982782 0.219278886150577 no 1133 0.23614984556219 792 NA Hydrophilin essential in dessication-rehydration process; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway biological_process molecular_function cytoplasm
YML062C YML062C MFT1 hom Verified 0.774159004411618 0.219418384052101 no 1134 0.232345617078452 802 NA FT TRANSCRIPTION FROM RNA POL II|RNA LOCALIZATION NUCLEUS Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance mRNA export from nucleus|DNA recombination|transcription elongation from RNA polymerase II promoter protein complex scaffold|nucleic acid binding THO complex part of transcription export complex|nucleoplasmic THO complex
YIL070C YIL070C MAM33 hom Verified 0.772303165145963 0.219967445609094 no 1135 0.231828274810047 800 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Acidic protein of the mitochondrial matrix involved in oxidative phosphorylation; related to the human complement receptor gC1q-R aerobic respiration molecular_function mitochondrion|mitochondrial matrix
YGL152C_d YGL152C YGL152C hom Dubious 0.77148939259598 0.220208453681239 no 1136 0.234815859599092 756 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PEX14/YGL153W Unknown Unknown Unknown
YGR111W_p YGR111W YGR111W hom Uncharacterized 0.771459897004772 0.220217191981605 no 1137 0.252633448139699 860 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus regulation of cell size molecular_function nucleus|cytoplasm
YPL106C YPL106C SSE1 hom Verified 0.770642267452915 0.220459500293948 no 1138 0.241275130201929 823 NA ATPase component of the heat shock protein Hsp90 chaperone complex; binds unfolded proteins; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm; SSE1 has a paralog, SSE2, that arose from the whole genome duplication protein folding|protein refolding peptide binding|adenyl-nucleotide exchange factor activity|ATP binding polysome|cytoplasm
YJR005W YJR005W APL1 hom Verified 0.770579828517919 0.220478010639822 no 1139 0.217586291918146 769 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|PLASMA MEMBRANE Beta-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport; similar to mammalian beta-chain of the clathrin associated protein complex vesicle-mediated transport molecular_function AP-2 adaptor complex
YGL220W YGL220W FRA2 hom Verified 0.769899360225 0.220679796728586 no 1140 0.220193593050927 740 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; null mutant fails to repress iron regulon and is sensitive to nickel negative regulation of transcription from RNA polymerase II promoter in response to iron molecular_function cytosol|nucleus|cytoplasm
YDL054C YDL054C MCH1 hom Verified 0.769616968191167 0.220763568320064 no 1141 0.226666038439951 780 NA Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport transport monocarboxylic acid transmembrane transporter activity|transporter activity integral to membrane|membrane
YKL119C YKL119C VPH2 hom Verified 0.769532684985634 0.220788574459755 no 1142 0.228603023815657 766 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Integral membrane protein required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER) vacuolar proton-transporting V-type ATPase complex assembly|vacuolar acidification molecular_function endoplasmic reticulum membrane
YDR246W-A_p YDR246W-A YDR246W-A hom Uncharacterized 0.769501904419711 0.220797707206956 no 1143 0.206935479456103 700 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YLR434C_d YLR434C YLR434C hom Dubious 0.76914430287313 0.2209038252209 no 1144 0.240067637011796 816 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TSR2/YLR435W Unknown Unknown Unknown
YPL021W YPL021W ECM23 hom Verified 0.768298648576493 0.221154888683009 no 1145 0.193201249130021 662 NA FT CELL WALL ORG/BIOGENESIS Non-essential protein of unconfirmed function; affects pre-rRNA processing, may act as a negative regulator of the transcription of genes involved in pseudohyphal growth; homologous to Srd1p pseudohyphal growth sequence-specific DNA binding cellular_component
YJR034W YJR034W PET191 hom Verified 0.768291060626097 0.221157142182844 no 1146 0.231910583436607 801 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Protein required for assembly of cytochrome c oxidase; exists as an oligomer; described as both an integral mitochondrial inner membrane protein facing the intermembrane space (IMS) and as a soluble IMS protein; contains a twin Cx9C motif; imported into the IMS via the MIA import machinery mitochondrial respiratory chain complex IV assembly molecular_function mitochondrion|integral to mitochondrial inner membrane
YIL055C_p YIL055C YIL055C hom Uncharacterized 0.766927232552419 0.221562390625936 no 1147 0.221039710349243 725 NA Putative protein of unknown function biological_process molecular_function cellular_component
YAR023C_p YAR023C YAR023C hom Uncharacterized 0.766482341833257 0.221694677390515 no 1148 0.221609938463453 759 NA Putative integral membrane protein, member of DUP240 gene family biological_process molecular_function cellular_component
YDR277C YDR277C MTH1 hom Verified 0.765920053300601 0.221861936547071 no 1149 0.214470973586447 679 NA FT SIGNALING Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation glucose transport|signal transduction molecular_function cellular_component
YDL094C_d YDL094C YDL094C hom Dubious 0.765367398788278 0.222026400161773 no 1150 0.198753849132002 713 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verfied gene PMT5/YDL093W; YDL094C is not essential Unknown Unknown Unknown
YKL170W YKL170W MRPL38 hom Verified 0.764380671738454 0.22232021176629 no 1151 0.237161162542068 797 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YNL193W_p YNL193W YNL193W hom Uncharacterized 0.764242552035519 0.22236135650523 no 1152 0.199599667841172 700 NA Putative protein of unknown function; exhibits a two-hybrid interaction with Yhr151cp in a large-scale analysis biological_process molecular_function cellular_component
YIL134C-A_p YIL134C-A YIL134C-A hom Uncharacterized 0.76303521767716 0.222721196497605 no 1153 0.21418331117817 750 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YGL253W YGL253W HXK2 hom Verified 0.762954609917402 0.2227452330519 no 1154 0.225394397338942 772 NA FT CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS|MITOCHONDRION Hexokinase isoenzyme 2; catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene; phosphorylation/dephosphorylation at serine-14 by protein kinase Snf1p and protein phosphatase Glc7p-Reg1p regulates nucleocytoplasmic shuttling of Hxk2p; HXK2 has a paralog, HXK1, that arose from the whole genome duplication replicative cell aging|fructose import|regulation of transcription by glucose|glucose import|mannose metabolic process|glycolysis|glucose metabolic process|regulation of cell size|fructose metabolic process hexokinase activity cytosol|mitochondrion|nucleus
YLR173W_p YLR173W YLR173W hom Uncharacterized 0.762214169999819 0.222966095140692 no 1155 0.225818846940863 746 NA Putative protein of unknown function biological_process molecular_function cellular_component
YGR231C YGR231C PHB2 hom Verified 0.761826820884707 0.22308168523221 no 1156 0.237307945165719 812 NA FT PROTEOLYSIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation mitochondrion inheritance|protein folding|negative regulation of proteolysis|replicative cell aging molecular_function mitochondrion|mitochondrial inner membrane
YDR058C YDR058C TGL2 hom Verified 0.758916848746759 0.223951149675695 no 1157 0.22973452408342 789 NA FT PROTEIN LOCALIZATION|LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION Triacylglycerol lipase that is localized to the mitochondria; has lipolytic activity towards triacylglycerols and diacylglycerols when expressed in E. coli triglyceride catabolic process triglyceride lipase activity mitochondrion
YER060W-A YER060W-A FCY22 hom Verified 0.758847029005309 0.22397203459568 no 1158 0.195862184867993 634 NA Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function transmembrane transport nucleobase transmembrane transporter activity integral to membrane
YBR280C YBR280C SAF1 hom Verified 0.758401640083946 0.224105288172267 no 1159 0.22501374966916 763 NA FT PROTEOLYSIS UBIQUITIN LIGASE COMPLEX F-Box protein involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence; interacts with Skp1 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity SCF ubiquitin ligase complex
YGL203C YGL203C KEX1 hom Verified 0.757906226959612 0.224253561114279 no 1160 0.223019920742053 741 NA FT PROTEOLYSIS GOLGI APPARATUS Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins protein processing serine-type carboxypeptidase activity trans-Golgi network
YNL294C YNL294C RIM21 hom Verified 0.755913854381345 0.224850423423672 no 1161 0.248862356393285 894 NA FF|FT ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS PLASMA MEMBRANE pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH fungal-type cell wall biogenesis|ascospore formation|invasive growth in response to glucose limitation molecular_function integral to membrane
YEL065W YEL065W SIT1 hom Verified 0.754596158305896 0.225245664724527 no 1162 0.19914143437386 692 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p cellular iron ion homeostasis|siderophore transport|transmembrane transport siderophore uptake transmembrane transporter activity endosome|integral to membrane|cytoplasmic membrane-bounded vesicle
YPR032W YPR032W SRO7 hom Verified 0.752488998429858 0.225878521711445 no 1163 0.225907644748526 792 NA FT VESICLE-MEDIATED TRANSPORT|SIGNALING PLASMA MEMBRANE Effector of Rab GTPase Sec4p; forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lgl tumor suppressor; SRO7 has a paralog, SRO77, that arose from the whole genome duplication establishment of cell polarity|exocytosis|Golgi to plasma membrane transport|small GTPase mediated signal transduction SNARE binding|Rab GTPase binding cytosol|plasma membrane
YFR033C YFR033C QCR6 hom Verified 0.75234219781537 0.225922648725226 no 1164 0.228755040990563 762 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Subunit 6 of the ubiquinol cytochrome-c reductase complex; the complex, also known as the cytochrome bc(1) complex or Complex III, is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1; may be loosely associated with the complex since it is easily released into the intermembrane space mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration ubiquinol-cytochrome-c reductase activity mitochondrion|integral to membrane|mitochondrial respiratory chain complex III
YLR113W YLR113W HOG1 hom Verified 0.751826387999203 0.226077735406461 no 1165 0.257114634460907 865 NA FT TRANSCRIPTION FROM RNA POL II|SIGNALING|PROTEIN PHOSPHORYLATION NUCLEUS Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNA Pol II in response to osmotic shock; acts via three independent osmosensors; mitophagy-specific regulator; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p; protein abundance increases in response to DNA replication stress negative regulation of transcription from RNA polymerase II promoter by pheromones|protein phosphorylation|hyperosmotic response|response to arsenic-containing substance|osmosensory signaling pathway|positive regulation of transcription from RNA polymerase II promoter|cellular response to heat MAP kinase activity nucleus|cytoplasm
YDR099W YDR099W BMH2 hom Verified 0.751700649005561 0.226115550017074 no 1166 0.237560291756901 781 NA FT CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS 14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress glycogen metabolic process|ascospore formation|Ras protein signal transduction|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|DNA damage checkpoint|DNA replication initiation|signal transduction involved in filamentous growth|pseudohyphal growth|fungal-type cell wall chitin biosynthetic process|pre-replicative complex assembly DNA replication origin binding|phosphoserine binding nucleus|plasma membrane
YPR003C_p YPR003C YPR003C hom Uncharacterized 0.751677515585524 0.226122507526403 no 1167 0.229791154316972 760 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Putative sulfate permease; physically interacts with Hsp82p; green fluorescent protein (GFP)-fusion protein localizes to the ER; YPR003C is not an essential gene biological_process molecular_function integral to membrane|endoplasmic reticulum
YLR250W YLR250W SSP120 hom Verified 0.751591726003717 0.226148310293553 no 1168 0.22632016953126 738 NA Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern biological_process molecular_function cytoplasm
YDL006W YDL006W PTC1 hom Verified 0.751474168297659 0.226183670600191 no 1169 0.292495191058451 1028 NA FF|FT RNA PROCESSING|SIGNALING|MITOCHONDRION ORGANIZATION|PROTEIN PHOSPHORYLATION NUCLEUS Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p, inactivating osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing, mitochondrial inheritance, and sporulation mitochondrion inheritance|inactivation of MAPK activity involved in osmosensory signaling pathway|pheromone-dependent signal transduction involved in conjugation with cellular fusion|tRNA splicing, via endonucleolytic cleavage and ligation|protein dephosphorylation protein serine/threonine phosphatase activity nucleus|cytoplasm
YNL053W YNL053W MSG5 hom Verified 0.750938187789129 0.226344928330809 no 1170 0.236617639824483 822 NA FT PROTEIN LOCALIZATION|CELL CYCLE|SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION NUCLEUS Dual-specificity protein phosphatase; exists in 2 isoforms; required for maintenance of a low level of signaling through the cell integrity pathway, adaptive response to pheromone; regulates and is regulated by Slt2p; dephosphorylates Fus3p adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|regulation of fungal-type cell wall organization|inactivation of MAPK activity involved in cell wall biogenesis|regulation of MAPK export from nucleus|protein dephosphorylation|inactivation of MAPK activity involved in conjugation with cellular fusion protein tyrosine/serine/threonine phosphatase activity nucleus|cytoplasm
YIR033W YIR033W MGA2 hom Verified 0.750101052643975 0.226596922796337 no 1171 0.183717187843268 587 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|GENE SILENCING ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting positive regulation of transcription from RNA polymerase II promoter in response to hypoxia|cellular response to cold|positive regulation of unsaturated fatty acid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|mRNA stabilization|positive regulation of transcription from RNA polymerase II promoter in response to cobalt ion|positive regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette molecular_function integral to endoplasmic reticulum membrane|nucleus
YER175W-A_p YER175W-A YER175W-A hom Uncharacterized 0.74966217727465 0.226729096331707 no 1172 0.218980853568748 768 NA Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YJL058C YJL058C BIT61 hom Verified 0.749617826806738 0.226742455523337 no 1173 0.209332567397315 708 NA FT SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION PLASMA MEMBRANE Subunit of TORC2 membrane-associated complex; involved in regulation of cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; BIT61 has a paralog, BIT2, that arose from the whole genome duplication fungal-type cell wall organization|TOR signaling cascade|regulation of cell growth|establishment or maintenance of actin cytoskeleton polarity molecular_function TORC2 complex|plasma membrane|cytoplasm
YFR026C YFR026C ULI1 hom Verified 0.748427455226355 0.227101183642125 no 1174 0.227739285566395 775 NA FT SIGNALING Putative protein of unknown function involved in and induced by the endoplasmic reticulum unfolded protein response endoplasmic reticulum unfolded protein response molecular_function cellular_component
YPL274W YPL274W SAM3 hom Verified 0.748335928314177 0.227128779258678 no 1175 0.265970287729369 874 NA FT ENDOPLASMIC RETICULUM|PLASMA MEMBRANE High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p spermidine transport|putrescine transport|S-adenosylmethionine transport S-adenosylmethionine transmembrane transporter activity|spermidine transmembrane transporter activity|putrescine transmembrane transporter activity integral to membrane|plasma membrane
YPL272C_p YPL272C YPL272C hom Uncharacterized 0.747009061589089 0.227529045508662 no 1176 0.256927245856641 887 NA Putative protein of unknown function; gene expression induced in response to ketoconazole; YPL272C is not an essential gene biological_process molecular_function cellular_component
YAL013W YAL013W DEP1 hom Verified 0.746715223468201 0.227617739215832 no 1177 0.233622531926766 787 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Transcriptional modulator involved in regulation of structural phospholipid biosynthesis genes and metabolically unrelated genes, as well as maintenance of telomeres, mating efficiency, and sporulation positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of chromatin silencing at rDNA|regulation of transcription from RNA polymerase II promoter|histone deacetylation|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of chromatin silencing at telomere|negative regulation of transcription from RNA polymerase II promoter|regulation of DNA-dependent DNA replication initiation|Unknown molecular_function Rpd3L-Expanded complex|Rpd3L complex
YLR396C YLR396C VPS33 hom Verified 0.746322449067441 0.227736326786505 no 1178 0.249751978246698 810 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT ATP-binding protein that is a subunit of the HOPS complex and of the CORVET tethering complex; essential for protein sorting, vesicle docking and fusion at the vacuole regulation of SNARE complex assembly|endocytosis|regulation of vacuole fusion, non-autophagic|piecemeal microautophagy of nucleus|vesicle fusion with vacuole|Golgi to vacuole transport|vacuole organization|vacuole fusion, non-autophagic|vesicle docking|protein targeting to vacuole phosphatidylinositol binding|ATP binding cytosol|fungal-type vacuole membrane|HOPS complex|fungal-type vacuole|CORVET complex
YHR010W YHR010W RPL27A hom Verified 0.745859012088609 0.227876293716651 no 1179 0.197269596554024 708 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L27A; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27A has a paralog, RPL27B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YPL058C YPL058C PDR12 hom Verified 0.74497939641797 0.228142087732316 no 1180 0.229483620631224 768 NA FT KETONE METABOLISM|NUCLEOTIDE METABOLISM PLASMA MEMBRANE Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity propionate metabolic process|transport|organic acid transport xenobiotic-transporting ATPase activity|organic acid transmembrane transporter activity integral to membrane|plasma membrane
YJR152W YJR152W DAL5 hom Verified 0.74469715478524 0.22822740978864 no 1181 0.223281241103607 742 NA FT PLASMA MEMBRANE Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression dipeptide transport|allantoate transport dipeptide transporter activity|allantoate transmembrane transporter activity integral to membrane|plasma membrane
YDR035W YDR035W ARO3 hom Verified 0.744254537009344 0.228361249902828 no 1182 0.311215798676251 1095 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS|MITOCHONDRION 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan aromatic amino acid family biosynthetic process 3-deoxy-7-phosphoheptulonate synthase activity mitochondrion|nucleus|cytoplasm
YDR447C YDR447C RPS17B hom Verified 0.744189972656885 0.228380776754426 no 1183 0.225617009100974 783 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17B has a paralog, RPS17A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress cytoplasmic translation|ribosomal small subunit assembly structural constituent of ribosome cytosolic small ribosomal subunit
YGL246C YGL246C RAI1 hom Verified 0.743494423528526 0.228591198219567 no 1184 0.226011772505472 754 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z deadenylation-dependent decapping of nuclear-transcribed mRNA|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|termination of RNA polymerase II transcription, poly(A)-coupled|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) enzyme regulator activity|m7G(5')pppN diphosphatase activity nucleus
YDL192W YDL192W ARF1 hom Verified 0.743188571966931 0.228683760624535 no 1185 0.257494989420546 876 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|RESPONSE TO NUTRIENT LEVELS GOLGI APPARATUS ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication ER to Golgi vesicle-mediated transport|Golgi to plasma membrane transport|intra-Golgi vesicle-mediated transport|macroautophagy GTPase activity cytosol|Golgi-associated vesicle
YFR035C_p YFR035C YFR035C hom Uncharacterized 0.743099852172582 0.228710614572065 no 1186 0.216922742078691 749 NA Putative protein of unknown function, deletion mutant exhibits synthetic phenotype with alpha-synuclein biological_process molecular_function cellular_component
YFL054C_p YFL054C YFL054C hom Uncharacterized 0.742762235282092 0.228812821553746 no 1187 0.219005666664771 736 NA Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol water transport|transmembrane transport water channel activity|glycerol transmembrane transporter activity|transporter activity integral to membrane
YNL285W_d YNL285W YNL285W hom Dubious 0.742438029728313 0.228910992639179 no 1188 0.219686909675088 743 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YER007W YER007W PAC2 hom Verified 0.742273372020277 0.228960860877593 no 1189 0.229699281687405 806 NA FT CYTOSKELETON Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl protein folding|tubulin complex assembly|tubulin complex biogenesis alpha-tubulin binding cellular_component
YJL065C YJL065C DLS1 hom Verified 0.741922382201099 0.229067182008666 no 1190 0.257759312997967 874 NA FT GENE SILENCING NUCLEUS Subunit of ISW2/yCHRAC chromatin accessibility complex; ISW2/yCHRAC also includes Itc1p, Isw2p, and Dpb4p; involved in inheritance of telomeric silencing; DLS1 has a paralog, DPB3, that arose from the whole genome duplication chromatin silencing at telomere molecular_function chromatin accessibility complex|nucleus
YHR141C YHR141C RPL42B hom Verified 0.741710987520043 0.229131230622204 no 1191 0.253786387515617 818 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L42B; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus; homologous to mammalian ribosomal protein L36A, no bacterial homolog; RPL42B has a paralog, RPL42A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YCL074W YCL074W YCL074W hom pseudogene 0.740861592899589 0.229388682457634 no 1192 0.224963431690195 747 NA FT NUCLEUS Pseudogene: encodes fragment of Ty Pol protein transposition, RNA-mediated ribonuclease activity|peptidase activity|RNA binding|RNA-directed DNA polymerase activity|DNA-directed DNA polymerase activity retrotransposon nucleocapsid
YKR103W YKR103W NFT1 hom Verified 0.739455600385874 0.229815195438938 no 1193 0.231299694796754 804 NA FT NUCLEOTIDE METABOLISM Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds. transport ATPase activity, coupled to transmembrane movement of substances integral to membrane|membrane
YNL166C YNL166C BNI5 hom Verified 0.739430093125152 0.229822937258542 no 1194 0.199055722051208 637 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner septin ring assembly|cytokinesis molecular_function cellular bud neck septin ring|cellular bud neck
YLR358C_p YLR358C YLR358C hom Uncharacterized 0.739160323627531 0.229904825109894 no 1195 0.201695309516385 737 NA Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps ORF RSC2/YLR357W biological_process molecular_function cellular_component
YBL089W YBL089W AVT5 hom Verified 0.739112511151545 0.229919340170231 no 1196 0.259290096665115 860 NA Putative transporter; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; AVT5 has a paralog, AVT6, that arose from the whole genome duplication transport transporter activity integral to membrane
YMR053C YMR053C STB2 hom Verified 0.737856860296256 0.230300718146986 no 1197 0.218070912051654 765 NA FT NUCLEUS|CHROMOSOME Protein that interacts with Sin3p in a two-hybrid assay and is part of a large protein complex with Sin3p and Stb1p biological_process molecular_function Sin3-type complex
YIL007C YIL007C NAS2 hom Verified 0.737131917662452 0.230521065459739 no 1198 0.201846961548119 700 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS NUCLEUS Proteasome-interacting protein; involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); similar to mammalian proteasomal modulator subunit; non-essential gene; interacts with Rpn4p; protein abundance increases in response to DNA replication stress proteasome regulatory particle assembly|ubiquitin-dependent protein catabolic process molecular_function cytosol|nucleus|cytoplasm
YEL016C YEL016C NPP2 hom Verified 0.737008237367371 0.230558670018534 no 1199 0.236268229352279 780 NA FT NUCLEOTIDE METABOLISM Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp1p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; NPP2 has a paralog, NPP1, that arose from the whole genome duplication nucleoside triphosphate metabolic process nucleotide diphosphatase activity|nucleoside-triphosphate diphosphatase activity|nucleoside-triphosphatase activity|phosphodiesterase I activity cellular_component
YDR423C YDR423C CAD1 hom Verified 0.736665521812267 0.230662889386882 no 1200 0.239269733079881 806 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS AP-1-like basic leucine zipper (bZIP) transcriptional activator; involved in stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins; binds consensus sequence TTACTAA; CAD1 has a paralog, YAP1, that arose from the whole genome duplication cellular response to cadmium ion|positive regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus|cytoplasm
YJL112W YJL112W MDV1 hom Verified 0.736564304060809 0.230693674611441 no 1201 0.250581833068095 882 NA FT MITOCHONDRION ORGANIZATION|PEROXISOME ORGANIZATION MITOCHONDRION Peripheral protein of cytosolic face of mitochondrial outer membrane; required for mitochondrial fission; interacts with Fis1p and with the dynamin-related GTPase Dnm1p; contains WD repeats; MDV1 has a paralog, CAF4, that arose from the whole genome duplication peroxisome fission|mitochondrial fission|mitochondrial genome maintenance ubiquitin binding mitochondrial outer membrane|mitochondrion
YLR448W YLR448W RPL6B hom Verified 0.735368033518786 0.231057692297051 no 1202 0.240575305342273 841 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal 60S subunit protein L6B; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6B has a paralog, RPL6A, that arose from the whole genome duplication cytoplasmic translation|ribosomal large subunit assembly structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YDR371W_p YDR371W CTS2 hom Uncharacterized 0.73536168700133 0.231059624357374 no 1203 0.216932954991522 708 NA FT CARBOHYDRATE METABOLISM Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect sporulation resulting in formation of a cellular spore molecular_function cytoplasm
YBR266C_d YBR266C SLM6 hom Dubious 0.733721235082935 0.23155932683623 no 1204 0.239848614983031 785 NA Protein with a potential role in actin cytoskeleton organization; gene exhibits synthetic genetic interaction with MSS4 encoding phosphatidylinositol 4-phosphate kinase Unknown Unknown Unknown
YMR226C YMR226C YMR226C hom Verified 0.73298042811817 0.231785183331315 no 1205 0.224066012181864 773 NA FT OXIDATION-REDUCTION PROCESS NUCLEUS NADP(+)-dependent dehydrogenase; acts on serine, L-allo-threonine, and other 3-hydroxy acids; green fluorescent protein fusion protein localizes to the cytoplasm and nucleus; may interact with ribosomes, based on co-purification experiments metabolic process oxidoreductase activity|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor|carbonyl reductase (NADPH) activity integral to membrane|ribosome|nucleus|cytoplasm
YNL319W_d YNL319W YNL319W hom Dubious 0.732223754991656 0.232016003727516 no 1206 0.245900271030668 860 NA Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HXT14 Unknown Unknown Unknown
YKL084W YKL084W HOT13 hom Verified 0.731956106207313 0.232097679649594 no 1207 0.232089037088065 805 NA FT PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Zinc-binding mitochondrial intermembrane space (IMS) protein involved in a disulfide relay system for IMS import of cysteine-containing proteins; binds Mia40p and stimulates its Erv1p-dependent oxidation, probably by sequestering zinc protein import into mitochondrial intermembrane space zinc ion binding mitochondrial intermembrane space
YBR191W YBR191W RPL21A hom Verified 0.731198732048675 0.232328887268955 no 1208 0.246016442864892 846 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YMR037C YMR037C MSN2 hom Verified 0.731147022999089 0.232344677435645 no 1209 0.227248162165786 768 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|RESPONSE TO OXIDATIVE STRESS NUCLEUS Transcriptional activator; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression; MSN2 has a paralog, MSN4, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription from RNA polymerase II promoter in response to a hypotonic environment|positive regulation of transcription from RNA polymerase II promoter in response to alkalinity|positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation|positive regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation|positive regulation of transcription from RNA polymerase II promoter in response to acidity|chromatin remodeling|positive regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide|regulation of replicative cell aging by regulation of transcription from RNA polymerase II promoter in response to caloric restriction|positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance|positive regulation of transcription from RNA polymerase II promoter in response to increased salt|positive regulation of transcription from RNA polymerase II promoter in response to freezing|positive regulation of transcription from RNA polymerase II promoter in response to ethanol|age-dependent response to oxidative stress involved in chronological cell aging|replicative cell aging|positive regulation of transcription from RNA polymerase II promoter in response to hydrostatic pressure|cellular response to methylmercury|positive regulation of transcription from RNA polymerase II promoter in response to nitrosative stress|positive regulation of transcription from RNA polymerase II promoter in response to cold|positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding cytosol|nucleus
YOR263C_d YOR263C YOR263C hom Dubious 0.730949646591499 0.232404954895649 no 1210 0.233851827620069 809 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF DES3/YOR264W Unknown Unknown Unknown
YKR046C YKR046C PET10 hom Verified 0.730947603138725 0.232405578998209 no 1211 0.225117198430099 766 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY Protein of unknown function that co-purifies with lipid particles; expression pattern suggests a role in respiratory growth; computational analysis of large-scale protein-protein interaction data suggests a role in ATP/ADP exchange aerobic respiration molecular_function lipid particle
YDR161W_p YDR161W YDR161W hom Uncharacterized 0.730273390317163 0.232611545064621 no 1212 0.236695971442574 806 NA FT PROTEOLYSIS NUCLEUS Putative protein of unknown function; non-essential gene; proposed function in rRNA and ribosome biosynthesis based on transcriptional co-regulation; genetic interactions suggest a role in ER-associated protein degradation (ERAD) ER-associated protein catabolic process molecular_function nucleus|cytoplasm
YJR008W YJR008W MHO1 hom Verified 0.728820661802818 0.233055685494194 no 1213 0.225568900849401 759 NA FT NUCLEUS Protein of unknown function; inhibits haploid invasive growth when overexpressed; synthetically lethal with phospholipase C (PLC1); expression induced by mild heat-stress on a non-fermentable carbon source, upon entry into stationary phase and upon nitrogen deprivation; repressed by inosine and choline in an Opi1p-dependent manner; highly conserved from bacteria to human; Memo, the human homolog, is an ErbB2 interacting protein with an essential function in cell motility biological_process molecular_function nucleus|cytoplasm
YLR393W YLR393W ATP10 hom Verified 0.728774534375383 0.233069795670002 no 1214 0.227099719239307 742 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, interacts genetically with ATP6 mitochondrial proton-transporting ATP synthase complex assembly unfolded protein binding integral to mitochondrial membrane|mitochondrion|mitochondrial inner membrane
YDR135C YDR135C YCF1 hom Verified 0.728676638355607 0.233099743200565 no 1215 0.208502343829724 719 NA FT NUCLEOTIDE METABOLISM Vacuolar glutathione S-conjugate transporter; member of the ATP-binding cassette family; has a role in detoxifying metals such as cadmium, mercury, and arsenite; also transports unconjugated bilirubin, selenodigluthatione, and oxidized glutathione; similar to human cystic fibrosis protein CFTR bilirubin transport|response to metal ion|transmembrane transport bilirubin transmembrane transporter activity|glutathione S-conjugate-exporting ATPase activity fungal-type vacuole membrane|integral to membrane
YHR035W_p YHR035W YHR035W hom Uncharacterized 0.727997307692779 0.233307617190535 no 1216 0.189720374686246 672 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM Putative protein of unknown function; not an essential gene biological_process molecular_function cellular_component
YHR080C YHR080C YHR080C hom Verified 0.727581942415574 0.233434768897092 no 1217 0.241499407044705 836 NA FT MITOCHONDRION Protein of unknown function; may interact with ribosomes, based on co-purification experiments; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YHR080C has a paralog, YSP2, that arose from the whole genome duplication biological_process molecular_function mitochondrion|ribosome
YDR432W YDR432W NPL3 hom Verified 0.727180251029069 0.233557771305068 no 1218 0.263587891147222 923 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION NUCLEUS RNA-binding protein; promotes elongation, regulates termination, and carries poly(A) mRNA from nucleus to cytoplasm; has a role in repressing translation initiation by binding eIF4G; required for pre-mRNA splicing; dissociation from mRNAs promoted by Mtr10p; phosphorylated by Sky1p in the cytoplasm; protein abundance increases in response to DNA replication stress translational termination|mRNA export from nucleus|negative regulation of translation|mRNA splicing, via spliceosome|Unknown|positive regulation of transcription elongation from RNA polymerase II promoter mRNA binding|RNA polymerase II core binding|eukaryotic initiation factor 4G binding|poly(A) RNA binding nucleus|cytoplasm
YGR100W YGR100W MDR1 hom Verified 0.726828279897317 0.233665578351651 no 1219 0.242458809397766 843 NA FT PROTEIN LOCALIZATION|SIGNALING|NUCLEOTIDE METABOLISM Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function intracellular protein transport Rab GTPase activator activity cytoplasm
YDR363W-A YDR363W-A SEM1 hom Verified 0.725282908402719 0.234139244462907 no 1220 0.243502865322736 863 NA FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|PROTEOLYSIS|RNA LOCALIZATION NUCLEUS Component of lid subcomplex of the 26S proteasome regulatory subunit; involved in mRNA export mediated by the TREX-2 complex (Sac3p-Thp1p); ortholog of human DSS1; protein abundance increases in response to DNA replication stress proteasome assembly|proteasomal ubiquitin-dependent protein catabolic process|regulation of cell cycle|mRNA export from nucleus|exocytosis|filamentous growth|ubiquitin-dependent protein catabolic process molecular_function cytosol|nucleus|proteasome storage granule|proteasome regulatory particle, lid subcomplex
YCR028C YCR028C FEN2 hom Verified 0.725243182815872 0.234151427611197 no 1221 0.257642581913319 858 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION PLASMA MEMBRANE Plasma membrane H+-pantothenate symporter; confers sensitivity to the antifungal agent fenpropimorph; relocalizes from vacuole to cytoplasm upon DNA replication stress pantothenate transmembrane transport|endocytosis pantothenate transmembrane transporter activity integral to membrane|plasma membrane
YPR157W_p YPR157W TDA6 hom Uncharacterized 0.725009107840692 0.234223221472353 no 1222 0.234606138509212 793 NA FT PROTEIN LOCALIZATION Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; null mutant is sensitive to expression of the top1-T722A allele biological_process molecular_function cellular_component
YOL121C YOL121C RPS19A hom Verified 0.721758558082209 0.235221466324947 no 1223 0.239361206313943 800 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION RIBOSOME Protein component of the small (40S) ribosomal subunit; required for assembly and maturation of pre-40 S particles; homologous to mammalian ribosomal protein S19, no bacterial homolog; mutations in human RPS19 are associated with Diamond Blackfan anemia; RPS19A has a paralog, RPS19B, that arose from the whole genome duplication cytoplasmic translation|ribosomal small subunit biogenesis|rRNA export from nucleus structural constituent of ribosome cytosolic small ribosomal subunit
YIL131C YIL131C FKH1 hom Verified 0.721555273939159 0.235283972905094 no 1224 0.236353277621202 808 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RNA PROCESSING|CHROMATIN ORGANIZATION|MITOCHONDRION ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Forkhead family transcription factor; has a minor role in the expression of G2/M phase genes; negatively regulates transcriptional elongation; positive role in chromatin silencing at HML and HMR; binds to the recombination enhancer near HML, and regulates donor preference during mating-type switching by positioning HML near the MAT locus through FHA-domain mediated interactions with proteins near the DSB; FKH1 has a paralog, FKH2, that arose from the whole genome duplication mRNA 3'-end processing|termination of RNA polymerase II transcription|donor selection|negative regulation of transcription involved in G1 phase of mitotic cell cycle|positive regulation of transcription involved in G2/M-phase of mitotic cell cycle|cellular response to methylmercury|positive regulation of chromatin silencing at silent mating-type cassette|negative regulation of transcription elongation from RNA polymerase II promoter|Unknown|negative regulation of transcription involved in G2/M-phase of mitotic cell cycle|chromatin remodeling RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|centromeric DNA binding nucleus
YLR376C YLR376C PSY3 hom Verified 0.72138409883591 0.235336613586954 no 1225 0.229282925918306 790 NA FT RESPONSE TO DNA DAMAGE NUCLEUS Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function; structural analysis reveals a similar DNA-binding region in both Psy3p and Csm2p and that both regions work together to form a single DNA binding site; deletion of PSY3 results in a mutator phenotype; deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C recombinational repair|error-free translesion synthesis molecular_function nucleus|Shu complex|cytoplasm
YLR149C YLR149C YLR149C hom Verified 0.72054724529442 0.235594060819645 no 1226 0.257850877930475 861 NA Protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene; protein abundance increases in response to DNA replication stress biological_process molecular_function cellular_component
YIL100W_d YIL100W YIL100W hom Dubious 0.719818035207202 0.235818519539521 no 1227 0.244675901969797 810 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YIL100C-A Unknown Unknown Unknown
YBR128C YBR128C ATG14 hom Verified 0.7182621942254 0.236297818039967 no 1228 0.229288374658765 786 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION Autophagy-specific subunit of phosphatidylinositol 3-kinase complex I (with Vps34/15/30p); Atg14p targets complex I to the phagophore assembly site (PAS); required for localizing additional ATG proteins to the PAS; required for overflow degradation of misfolded proteins when ERAD is saturated; homolog of human Barkor piecemeal microautophagy of nucleus|ER-associated protein catabolic process|peroxisome degradation|macroautophagy|CVT pathway 1-phosphatidylinositol-3-kinase activity phosphatidylinositol 3-kinase complex I|fungal-type vacuole membrane|pre-autophagosomal structure|extrinsic to membrane
YML081W YML081W TDA9 hom Verified 0.718102341066067 0.236347093403033 no 1229 0.22172715023665 734 NA FT NUCLEUS DNA-binding protein, putative transcription factor; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; TDA9 has a paralog, RSF2, that arose from the whole genome duplication biological_process sequence-specific DNA binding nucleus
YNR027W YNR027W BUD17 hom Verified 0.718028634962777 0.236369815503792 no 1230 0.24815795913072 839 NA FT CELL CYCLE|CELL DIVISION|COFACTOR METABOLISM NUCLEUS Putative pyridoxal kinase, a key enzyme in vitamin B6 metabolism; involved in bud-site selection; diploid mutants display a random rather than a bipolar budding pattern; similarity to yeast BUD16 and human pyridoxal kinase (PDXK) pyridoxal phosphate biosynthetic process|cellular bud site selection pyridoxal kinase activity nucleus|cytoplasm
YGR011W_d YGR011W YGR011W hom Dubious 0.716739301464117 0.236767485398313 no 1231 0.220949003251615 736 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR054C YLR054C OSW2 hom Verified 0.715987730998086 0.236999462364629 no 1232 0.242734556519824 826 NA FT CELL WALL ORG/BIOGENESIS Protein of unknown function proposed to be involved in the assembly of the spore wall ascospore wall assembly molecular_function integral to membrane|prospore membrane|cytoplasm
YDR017C YDR017C KCS1 hom Verified 0.715170768244909 0.237251764703564 no 1233 0.216036820727187 739 NA Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response and telomere maintenance inositol phosphate biosynthetic process inositol heptakisphosphate kinase activity|inositol hexakisphosphate kinase activity|inositol-1,3,4,5,6-pentakisphosphate kinase activity|inositol heptakisphosphate 5-kinase activity cytoplasm
YPR174C YPR174C YPR174C hom Verified 0.713467316654295 0.237778315275211 no 1234 0.22764227459495 751 NA FT ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery; potential Cdc28p substrate; binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study; relative distribution to foci at the nuclear periphery increases upon DNA replication stress; YPR174C has a paralog, NBP1, that arose from the whole genome duplication biological_process molecular_function nuclear envelope|spindle pole body
YMR114C YMR114C YMR114C hom Verified 0.712584036180734 0.238051596510404 no 1235 0.230178647964442 759 NA FT NUCLEUS Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR114C is not an essential gene biological_process molecular_function ribosome|nucleus|cytoplasm
YDR332W YDR332W IRC3 hom Verified 0.712153049811216 0.238185003357112 no 1236 0.239005850843997 831 NA FT MITOCHONDRION Putative RNA helicase of the DEAH/D-box family; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion biological_process ATP-dependent RNA helicase activity mitochondrion
YIL014C-A_p YIL014C-A YIL014C-A hom Uncharacterized 0.712016565665243 0.23822725898464 no 1237 0.250418454219965 880 NA Putative protein of unknown function biological_process molecular_function cellular_component
YDR380W YDR380W ARO10 hom Verified 0.711478866733803 0.238393771063356 no 1238 0.219956338157058 730 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Phenylpyruvate decarboxylase, catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde, which is the first specific step in the Ehrlich pathway L-phenylalanine catabolic process|methionine catabolic process to 3-methylthiopropanol|tryptophan catabolic process|branched-chain amino acid catabolic process to alcohol via Ehrlich pathway|aromatic amino acid family catabolic process to alcohol via Ehrlich pathway|leucine catabolic process pyruvate decarboxylase activity|carboxy-lyase activity|phenylpyruvate decarboxylase activity cytoplasm
YPL152W-A_p YPL152W-A YPL152W-A hom Uncharacterized 0.710421017199447 0.238721546889877 no 1239 0.224927099210437 762 NA Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YOR295W YOR295W UAF30 hom Verified 0.710340551927393 0.238746489228989 no 1240 0.228375998078177 802 NA FT CHROMATIN ORGANIZATION NUCLEUS Subunit of UAF (upstream activation factor); UAF is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; deletion decreases cellular growth rate; UAF30 has a paralog, TRI1, that arose from the whole genome duplication transcription of nuclear large rRNA transcript from RNA polymerase I promoter|chromatin organization RNA polymerase I upstream control element sequence-specific DNA binding|RNA polymerase I upstream control element sequence-specific DNA binding transcription factor activity nucleolus|RNA polymerase I upstream activating factor complex
YNL259C YNL259C ATX1 hom Verified 0.709181921311534 0.239105795452695 no 1241 0.24945910605321 870 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake copper ion transport|cellular response to oxidative stress|cellular iron ion homeostasis copper chaperone activity cytosol
YPL061W YPL061W ALD6 hom Verified 0.708820252628766 0.239218014051622 no 1242 0.244749870911788 836 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM MITOCHONDRION Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress response to salt stress|NADPH regeneration|acetate biosynthetic process aldehyde dehydrogenase [NAD(P)+] activity cytosol|mitochondrion
YEL027W YEL027W VMA3 hom Verified 0.708798827139823 0.239224662857492 no 1243 0.256860161994405 852 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis cellular copper ion homeostasis|cellular iron ion homeostasis|endocytosis|vacuole organization|proton transport|vacuolar acidification|protein targeting to vacuole hydrogen ion transmembrane transporter activity vacuolar proton-transporting V-type ATPase, V0 domain|integral to membrane
YJL189W YJL189W RPL39 hom Verified 0.708419636583588 0.239342350828394 no 1244 0.236896899647155 794 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YJL210W YJL210W PEX2 hom Verified 0.70805815699758 0.239454571348654 no 1245 0.229703173991893 783 NA FT PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION RING-finger peroxin and E3 ubiquitin ligase, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import protein import into peroxisome matrix ubiquitin-protein ligase activity|protein binding peroxisomal membrane
YLR224W_p YLR224W YLR224W hom Uncharacterized 0.707810010868037 0.239531624382543 no 1246 0.218140821983859 737 NA FT PROTEOLYSIS F-box protein and component of SCF ubiquitin ligase complexes involved in ubiquitin-dependent protein catabolism; readily monoubiquitinated in vitro by SCF-Ubc4 complexes; YLR224W is not an essential gene SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular response to methylmercury ubiquitin-protein ligase activity|protein binding, bridging SCF ubiquitin ligase complex
YPR060C YPR060C ARO7 hom Verified 0.707634400426065 0.239586162194034 no 1247 0.291835739625905 1046 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Chorismate mutase, catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis aromatic amino acid family biosynthetic process chorismate mutase activity nucleus|cytoplasm
YBR028C YBR028C YPK3 hom Verified 0.707609760757894 0.239593814864243 no 1248 0.271450749054039 911 NA FT PROTEIN PHOSPHORYLATION An AGC kinase phosphorylated by cAMP-dependent protein kinase (PKA) in a TORC1-dependent manner biological_process protein kinase activity cytoplasm
YNL083W YNL083W SAL1 hom Verified 0.706717016980374 0.239871176177816 no 1249 0.228966331399557 773 NA FT MITOCHONDRION ADP/ATP transporter; member of the Ca2+-binding subfamily of mitochondrial carriers, with two EF-hand motifs; transport activity of either Sal1p or Pet9p is critical for viability; polymorphic in different S. cerevisiae strains ATP transport|ADP transport|mitochondrial transport ATP:ADP antiporter activity|calcium ion binding mitochondrion|integral to membrane|mitochondrial inner membrane
YKL085W YKL085W MDH1 hom Verified 0.704369094329585 0.240601473752445 no 1250 0.246380053262175 828 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated chronological cell aging|replicative cell aging|tricarboxylic acid cycle|aerobic respiration L-malate dehydrogenase activity|mRNA binding mitochondrion|mitochondrial matrix
YBR205W YBR205W KTR3 hom Verified 0.70346044821145 0.240884423456094 no 1251 0.19733516190117 656 NA FT CARBOHYDRATE METABOLISM Putative alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; Svp26p mediates uptake of Ktr3p into COPII vesicles; relocalizes from nucleus to vacuole upon DNA replication stress N-glycan processing|protein O-linked glycosylation mannosyltransferase activity fungal-type vacuole
YGL057C YGL057C GEP7 hom Verified 0.703130438481972 0.240987232298144 no 1252 0.254372883485677 872 NA FT MITOCHONDRION Protein of unknown function; null mutant exhibits a respiratory growth defect and synthetic interactions with prohibitin (phb1) and gem1; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YPL247C_p YPL247C YPL247C hom Uncharacterized 0.702821527447377 0.241083489824882 no 1253 0.236637575436999 831 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; overexpression causes a cell cycle delay or arrest biological_process molecular_function nucleus|cytoplasm
YKL071W_p YKL071W YKL071W hom Uncharacterized 0.702721779122774 0.241114576141055 no 1254 0.246205697414974 843 NA FT OXIDATION-REDUCTION PROCESS Putative protein of unknown function; expression induced in cells treated with the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm biological_process molecular_function integral to membrane|cytoplasm
YGL033W YGL033W HOP2 hom Verified 0.702277467009477 0.241253071369832 no 1255 0.278872130486787 980 NA FF|FT CELL CYCLE NUCLEUS|CHROMOSOME Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair synapsis|reciprocal meiotic recombination protein binding|double-stranded DNA binding condensed nuclear chromosome
YDR503C YDR503C LPP1 hom Verified 0.701362151469554 0.241538517916637 no 1256 0.221936785199905 751 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Lipid phosphate phosphatase, catalyzes Mg(2+)-independent dephosphorylation of phosphatidic acid (PA), lysophosphatidic acid, and diacylglycerol pyrophosphate; involved in control of the cellular levels of phosphatidylinositol and PA phospholipid metabolic process phosphatidate phosphatase activity integral to membrane|membrane
YOR348C YOR348C PUT4 hom Verified 0.699661996137176 0.242069207743591 no 1257 0.257894867097928 900 NA FT PLASMA MEMBRANE Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells neutral amino acid transport|proline transport|gamma-aminobutyric acid transport neutral amino acid transmembrane transporter activity|L-proline transmembrane transporter activity integral to membrane|plasma membrane
YGL086W YGL086W MAD1 hom Verified 0.69790556344253 0.242618127445672 no 1258 0.233662863898201 798 NA FT CELL CYCLE|CELL DIVISION ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME NUCLEAR PORE|KINETOCHORE Coiled-coil protein involved in the spindle-assembly checkpoint; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon spindle assembly checkpoint arrest; phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of the activity of the anaphase promoting complex; forms a complex with Mad2p nucleocytoplasmic transport|mitotic cell cycle spindle assembly checkpoint|mitotic cell cycle G2/M transition decatenation checkpoint molecular_function nucleus|nuclear pore|kinetochore
YPL144W YPL144W POC4 hom Verified 0.697474217008376 0.242753034685533 no 1259 0.232745610239533 797 NA FT PROTEIN COMPLEX ORG/BIOGENESIS Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions proteasome assembly|chaperone-mediated protein complex assembly molecular_function intracellular|cytoplasm
YML094W YML094W GIM5 hom Verified 0.697135410399295 0.242859027778643 no 1260 0.234723828475181 823 NA FT PROTEIN COMPLEX ORG/BIOGENESIS Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it tubulin complex assembly tubulin binding prefoldin complex|cytoplasm
YDR105C YDR105C TMS1 hom Verified 0.697094351768807 0.242871874362716 no 1261 0.251456696311315 871 NA Vacuolar membrane protein of unknown function that is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p, a protein involved in multidrug resistance biological_process molecular_function fungal-type vacuole membrane|integral to membrane|membrane
YDR401W_d YDR401W YDR401W hom Dubious 0.697065356319301 0.242880946793306 no 1262 0.257287501806456 885 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YCL014W YCL014W BUD3 hom Verified 0.696957964853265 0.242914550270796 no 1263 0.239944439940186 809 NA FT CELL CYCLE|SIGNALING|CELL DIVISION SITE OF POLARIZED GROWTH|CYTOSKELETON Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding cellular bud site selection|axial cellular bud site selection|cytokinesis molecular_function cellular bud neck contractile ring|cellular bud neck
YDR140W YDR140W MTQ2 hom Verified 0.696842543056331 0.242950669294622 no 1264 0.231752496522913 823 NA FT TRANSLATION NUCLEUS S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC peptidyl-glutamine methylation|regulation of translation protein methyltransferase activity|S-adenosylmethionine-dependent methyltransferase activity eRF1 methyltransferase complex|nucleus|cytoplasm
YDR252W YDR252W BTT1 hom Verified 0.694613077339946 0.243648907291007 no 1265 0.239367824021489 786 NA FT PROTEIN LOCALIZATION NUCLEUS Beta3 subunit of the heterotrimeric nascent polypeptide-associated complex which binds ribosomes via its beta-subunits in close proximity to nascent polypeptides; interacts with Caf130p of the CCR4-NOT complex; similar to human BTF3 'de novo' cotranslational protein folding unfolded protein binding nascent polypeptide-associated complex|CCR4-NOT complex
YGL012W YGL012W ERG4 hom Verified 0.694266912511029 0.243757418454466 no 1266 0.363990567385367 1228 NA FF|FT LIPID METABOLISM|OXIDATION-REDUCTION PROCESS ENDOPLASMIC RETICULUM C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol ergosterol biosynthetic process delta24(24-1) sterol reductase activity integral to membrane|endoplasmic reticulum
YFL046W_p YFL046W FMP32 hom Uncharacterized 0.694012115028957 0.243837305657269 no 1267 0.238970242932165 774 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YPL207W YPL207W TYW1 hom Verified 0.693727792662855 0.243926466538749 no 1268 0.240762389856048 840 NA FT RNA PROCESSING|OXIDATION-REDUCTION PROCESS ENDOPLASMIC RETICULUM Iron-sulfer protein required for synthesis of Wybutosine modified tRNA; Wybutosine is a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions; induction by Yap5p in response to iron provides protection from high iron toxicity; overexpression results in increased cellular iron wybutosine biosynthetic process molecular_function endoplasmic reticulum
YLR217W_d YLR217W YLR217W hom Dubious 0.693126293417282 0.244115149133063 no 1269 0.253886292215478 859 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CPR6 Unknown Unknown Unknown
YOL006C YOL006C TOP1 hom Verified 0.69162230536231 0.244587275131029 no 1270 0.243595864975815 827 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|CHROMOSOME SEGREGATION|GENE SILENCING NUCLEUS|CHROMOSOME Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination nuclear migration|chromatin assembly or disassembly|DNA topological change|DNA strand elongation involved in DNA replication|regulation of mitotic recombination|chromatin silencing at rDNA|regulation of transcription from RNA polymerase II promoter|mitotic chromosome condensation|transcription elongation from RNA polymerase II promoter DNA topoisomerase type I activity replication fork protection complex|nucleolus|nucleus
YOR352W YOR352W TFB6 hom Verified 0.691483700411306 0.244630810186921 no 1271 0.241133325156149 844 NA FT NUCLEUS Subunit of TFIIH complex; facilities dissociation of the Ssl2p helices from TFIIH; expression levels regulated by Arg5,6p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus biological_process molecular_function nucleus|holo TFIIH complex|cytoplasm
YLR334C_d YLR334C YLR334C hom Dubious 0.689042669448644 0.245398208100744 no 1272 0.218224426303465 724 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps a stand-alone long terminal repeat sequence whose presence indicates a retrotransposition event occurred here Unknown Unknown Unknown
YFL028C YFL028C CAF16 hom Verified 0.688954275029377 0.245426021304312 no 1273 0.233348776596495 785 NA FT TRANSCRIPTION FROM RNA POL II|NUCLEOTIDE METABOLISM NUCLEUS Part of evolutionarily-conserved CCR4-NOT regulatory complex; contains single ABC-type ATPase domain but no transmembrane domain; interacts with several subunits of Mediator regulation of transcription from RNA polymerase II promoter ATPase activity CCR4-NOT complex|cytoplasm
YLL030C_d YLL030C RRT7 hom Dubious 0.685993298669205 0.246358667124356 no 1274 0.230761063629678 801 NA Identified in a screen for mutants with increased levels of rDNA transcription; dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YMR219W YMR219W ESC1 hom Verified 0.684063726535774 0.246967462930452 no 1275 0.262902204930948 899 NA FT GENE SILENCING NUCLEUS Protein localized to the nuclear periphery, involved in telomeric silencing; interacts with PAD4-domain of Sir4p chromatin silencing at telomere molecular_function nuclear periphery
YIL077C_p YIL077C YIL077C hom Uncharacterized 0.683486399858499 0.247149770565447 no 1276 0.266208961022774 900 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) biological_process molecular_function mitochondrion
YBR217W YBR217W ATG12 hom Verified 0.682898917731644 0.247335358939352 no 1277 0.252003448397969 863 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Conserved ubiquitin-like modifier involved in autophagy and the Cvt pathway; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg12p-Atg5p also forms a complex with Atg16p that is required for autophagosome formation C-terminal protein lipidation|piecemeal microautophagy of nucleus|mitochondrion degradation|CVT pathway|autophagic vacuole assembly Atg8 ligase activity|protein tag Atg12-Atg5-Atg16 complex|pre-autophagosomal structure
YNL121C YNL121C TOM70 hom Verified 0.681706543002887 0.247712264666358 no 1278 0.291055312879334 994 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Component of the TOM (translocase of outer membrane) complex; involved in the recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins; TOM70 has a paralog, TOM71, that arose from the whole genome duplication protein import into mitochondrial matrix|protein import into mitochondrial inner membrane mitochondrion targeting sequence binding|protein channel activity mitochondrial outer membrane|mitochondrion|integral to membrane|integral to mitochondrial outer membrane|mitochondrial outer membrane translocase complex
YPL264C_p YPL264C YPL264C hom Uncharacterized 0.680611197935205 0.248058769739457 no 1279 0.232978511256513 772 NA Putative membrane protein of unknown function; physically interacts with Hsp82p; YPL264C is not an essential gene biological_process molecular_function integral to membrane
YLR062C_d YLR062C BUD28 hom Dubious 0.680551669316398 0.248077608624895 no 1280 0.268980246077278 925 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene RPL22A; diploid mutant displays a weak budding pattern phenotype in a systematic assay Unknown Unknown Unknown
YKR064W YKR064W OAF3 hom Verified 0.680436311810261 0.24811411772276 no 1281 0.261902726979133 881 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS|MITOCHONDRION Putative transcriptional repressor with Zn(2)-Cys(6) finger; negatively regulates transcription in response to oleate levels, based on mutant phenotype and localization to oleate-responsive promoters; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress negative regulation of transcription from RNA polymerase II promoter|cellular response to oleic acid RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity mitochondrion|nucleus|cytoplasm
YJL055W_p YJL055W YJL055W hom Uncharacterized 0.680136845835272 0.248208908048527 no 1282 0.251002181646361 871 NA FT NUCLEUS Putative protein of unknown function, proposed to be involved in the metabolism of purine and pyrimidine base analogues; deletion mutants are sensitive to HAP and AHA; overexpression confers resistance to 5-FOA and 5-FU response to chemical stimulus|response to purine-containing compound molecular_function nucleus|cytoplasm
YFR038W YFR038W IRC5 hom Verified 0.679785731968122 0.248320071134444 no 1283 0.241479798045155 838 NA FT NUCLEUS Putative ATPase containing the DEAD/H helicase-related sequence motif; null mutant displays increased levels of spontaneous Rad52p foci mitotic recombination molecular_function cellular_component
YKL161C YKL161C KDX1 hom Verified 0.678448246275562 0.248743763765563 no 1284 0.271036836488046 937 NA FT PROTEIN PHOSPHORYLATION Protein kinase implicated in the Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p biological_process protein kinase activity cellular_component
YLR356W YLR356W ATG33 hom Verified 0.675007590301508 0.249835471288243 no 1285 0.241353946764563 825 NA FT MITOCHONDRION Mitochondrial mitophagy-specific protein; required primarily for mitophagy induced at the post-log phase; not required for other types of selective autophagy or macroautophagy; conserved within fungi, but not in higher eukaryotes mitochondrion degradation molecular_function mitochondrion|integral to membrane
YPL008W YPL008W CHL1 hom Verified 0.674490759476595 0.249999679274407 no 1286 0.25677376356936 912 NA FT CELL CYCLE|CHROMOSOME SEGREGATION NUCLEUS Probable DNA helicase; involved in sister-chromatid cohesion and genome integrity and interstrand cross-link repair; interacts with ECO1 and CTF18; mutants are defective in silencing, rDNA recombination, aging and the heat shock response; FANCJ-like helicase family member; mutations in the human homolog, DDX11/ChLR1, cause Warsaw breakage syndrome negative regulation of DNA recombination|chromosome segregation|donor selection|DNA replication initiation|mitotic sister chromatid cohesion DNA helicase activity nucleus
YPR071W_p YPR071W YPR071W hom Uncharacterized 0.674095795487106 0.250125206208034 no 1287 0.262607145946562 919 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Putative membrane protein; YPR071W is not an essential gene; YPR071W has paralog YIL029C biological_process molecular_function integral to membrane
YBR208C YBR208C DUR1,2 hom Verified 0.673621998056033 0.250275831979357 no 1288 0.23800183605851 806 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Urea amidolyase; contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; protein abundance increases in response to DNA replication stress allantoin catabolic process|urea catabolic process urea carboxylase activity|allophanate hydrolase activity cytoplasm
YJL110C YJL110C GZF3 hom Verified 0.673280449363255 0.250384444147054 no 1289 0.253532671210185 846 NA FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS NUCLEUS GATA zinc finger protein; negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p; GZF3 has a paralog, DAL80, that arose from the whole genome duplication maintenance of protein location in nucleus|nitrogen catabolite repression of transcription|negative regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding RNA polymerase II transcription factor activity|sequence-specific DNA binding nucleus
YOL041C YOL041C NOP12 hom Verified 0.673222492246452 0.250402876935635 no 1290 0.249217654521036 835 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Nucleolar protein involved in pre-25S rRNA processing and biogenesis of large 60S ribosomal subunit; contains an RNA recognition motif (RRM); binds to Ebp2; similar to Nop13p and Nsr1p maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) RNA binding nucleolus|preribosome
YLL007C_p YLL007C YLL007C hom Uncharacterized 0.672688253984966 0.250572820926148 no 1291 0.272986021880933 991 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL007C is not an essential gene biological_process molecular_function cytoplasm
YGL167C YGL167C PMR1 hom Verified 0.671051902221111 0.251093732973947 no 1292 0.293487504793976 1003 NA FT VESICLE-MEDIATED TRANSPORT|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|GOLGI APPARATUS High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease manganese ion transport|calcium ion transport|exocytosis manganese-transporting ATPase activity|calcium-transporting ATPase activity|calcium ion binding integral to membrane|Golgi membrane
YDR372C YDR372C VPS74 hom Verified 0.670231370146987 0.251355154553092 no 1293 0.28954205450895 988 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33 retrograde vesicle-mediated transport, Golgi to ER|endoplasmic reticulum unfolded protein response|protein localization to Golgi apparatus enzyme binding|phosphatidylinositol-4-phosphate binding cytosol|Golgi apparatus|nucleus|extrinsic to membrane|cytoplasm
YLR284C YLR284C ECI1 hom Verified 0.670131773295325 0.251386895906394 no 1294 0.251958719077475 853 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS Peroxisomal delta3,delta2-enoyl-CoA isomerase, hexameric protein that converts 3-hexenoyl-CoA to trans-2-hexenoyl-CoA, essential for the beta-oxidation of unsaturated fatty acids, oleate-induced fatty acid beta-oxidation dodecenoyl-CoA delta-isomerase activity peroxisome
YDR218C YDR218C SPR28 hom Verified 0.669268850233005 0.251661996749205 no 1295 0.23319447856932 799 NA FT CELL CYCLE|CELL DIVISION SITE OF POLARIZED GROWTH|CYTOSKELETON Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; meiotic septin expressed at high levels during meiotic divisions and ascospore formation sexual sporulation resulting in formation of a cellular spore structural molecule activity spindle microtubule|meiotic spindle|septin complex|prospore membrane|ascospore wall
YPR012W_d YPR012W YPR012W hom Dubious 0.668423196160428 0.251931746404772 no 1296 0.247590980298865 851 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR012W is not an essential gene Unknown Unknown Unknown
YGL076C YGL076C RPL7A hom Verified 0.667526851339634 0.252217832075984 no 1297 0.235902387899989 799 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L7A; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7A has a paralog, RPL7B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit|cytoplasm
YKL215C YKL215C OXP1 hom Verified 0.666999978915507 0.252386073444821 no 1298 0.217619646349484 690 NA FT KETONE METABOLISM|AMINO ACID METABOLISM 5-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress glutathione metabolic process 5-oxoprolinase (ATP-hydrolyzing) activity cytoplasm
YMR173W-A_d YMR173W-A YMR173W-A hom Dubious 0.666928301573529 0.25240896608732 no 1299 0.267458893275192 930 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene DDR48/YML173W Unknown Unknown Unknown
YKR077W YKR077W MSA2 hom Verified 0.666256481747069 0.252623588215228 no 1300 0.250788947850133 872 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE NUCLEUS Putative transcriptional activator, that interacts with G1-specific transcription factor, MBF and G1-specific promoters; ortholog of Msa2p, an MBF and SBF activator that regulates G1-specific transcription and cell cycle initiation regulation of transcription involved in G1 phase of mitotic cell cycle molecular_function nucleus|cytoplasm
YBR074W_p YBR074W YBR074W hom Uncharacterized 0.665875351953978 0.252745388116175 no 1301 0.267670645050688 946 NA FT PROTEOLYSIS Putative metalloprotease biological_process molecular_function cellular_component
YLR269C_d YLR269C YLR269C hom Dubious 0.665348029753619 0.252913958563333 no 1302 0.241059151389671 816 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YMR009W YMR009W ADI1 hom Verified 0.664694241769905 0.253123038785478 no 1303 0.237981622240445 825 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS NUCLEUS Acireductone dioxygenease involved in the methionine salvage pathway; ortholog of human MTCBP-1; transcribed as polycistronic mRNA with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions L-methionine salvage from methylthioadenosine oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen nucleus|cytoplasm
YNR002C YNR002C ATO2 hom Verified 0.664667127179004 0.253131711945943 no 1304 0.224598199535001 763 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION|PLASMA MEMBRANE Putative transmembrane protein involved in export of ammonia; ammonia is a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Y. lipolytica Gpr1p; ATO2 has a paralog, ADY2, that arose from the whole genome duplication ammonium transport|nitrogen utilization ammonium transmembrane transporter activity mitochondrion|integral to membrane|plasma membrane
YDR004W YDR004W RAD57 hom Verified 0.664652508587006 0.253136388068594 no 1305 0.267349757119851 957 NA FF|FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p DNA recombinase assembly|telomere maintenance via recombination|heteroduplex formation|meiotic DNA recombinase assembly|double-strand break repair via single-strand annealing DNA-dependent ATPase activity|protein heterodimerization activity nucleus|Rhp55-Rhp57 complex
YNL077W YNL077W APJ1 hom Verified 0.664484490230839 0.253190136208353 no 1306 0.283506581657929 970 NA FT NUCLEUS|MITOCHONDRION Chaperone with a role in SUMO-mediated protein degradation; member of the DnaJ-like family; conserved across eukaryotes; overexpression interferes with propagation of the [Psi+] prion; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress biological_process unfolded protein binding mitochondrion|nucleus|cytoplasm
YLR225C_p YLR225C YLR225C hom Uncharacterized 0.664320357913387 0.253242647020385 no 1307 0.259881518745364 901 NA FT RESPONSE TO OXIDATIVE STRESS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR225C is not an essential gene biological_process molecular_function cytoplasm
YHL037C_d YHL037C YHL037C hom Dubious 0.664124060557606 0.25330545590418 no 1308 0.238468082335013 774 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YCR014C YCR014C POL4 hom Verified 0.663307118607229 0.253566939172892 no 1309 0.250030617743649 884 NA FT RESPONSE TO DNA DAMAGE NUCLEUS DNA polymerase IV, undergoes pair-wise interactions with Dnl4p-Lif1p and Rad27p to mediate repair of DNA double-strand breaks by non-homologous end joining (NHEJ); homologous to mammalian DNA polymerase beta double-strand break repair|base-excision repair, gap-filling|double-strand break repair via nonhomologous end joining DNA-directed DNA polymerase activity nucleus
YOR080W YOR080W DIA2 hom Verified 0.663026656760778 0.253656740881364 no 1310 0.262445435809113 923 NA FT CELL CYCLE|PROTEOLYSIS NUCLEUS|CHROMOSOME UBIQUITIN LIGASE COMPLEX Origin-binding F-box protein; forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays a role in DNA replication; plays a role in transcription; required for correct assembly of RSC complex, correct RSC-mediated transcription regulation, and correct nucleosome positioning; involved in invasive and pseudohyphal growth; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|regulation of DNA replication|invasive growth in response to glucose limitation|protein ubiquitination ubiquitin-protein ligase activity|DNA replication origin binding SCF ubiquitin ligase complex|nucleus|nuclear replication fork
YLR278C_p YLR278C YLR278C hom Uncharacterized 0.662977799369893 0.253672386347232 no 1311 0.266303205020263 909 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Zinc-cluster protein; GFP-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; has a prion-domain like fragment that increases frequency of [URE3]; YLR278C is not an essential gene biological_process sequence-specific DNA binding nucleus
YOR184W YOR184W SER1 hom Verified 0.662097546578036 0.253954354038477 no 1312 0.262205719675507 909 NA FT KETONE METABOLISM|AMINO ACID METABOLISM 3-phosphoserine aminotransferase; catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p; protein abundance increases in response to DNA replication stress serine family amino acid biosynthetic process|L-serine biosynthetic process|purine nucleobase biosynthetic process O-phospho-L-serine:2-oxoglutarate aminotransferase activity cytoplasm
YGR049W YGR049W SCM4 hom Verified 0.661859285918667 0.254030703351621 no 1313 0.262454524286384 870 NA FT MITOCHONDRION Mitochondrial outer membrane protein of unknown function; predicted to have 4 transmembrane segments; import is mediated by Tom70p and Mim1p; interacts genetically with a cdc4 mutation biological_process molecular_function mitochondrial outer membrane|mitochondrion|integral to membrane
YJL162C YJL162C JJJ2 hom Verified 0.661809787891648 0.254046566231805 no 1314 0.240903432484784 821 NA FT NUCLEUS Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein biological_process molecular_function nucleus|cytoplasm
YBR059C YBR059C AKL1 hom Verified 0.661247892511183 0.254226676080088 no 1315 0.258155302052398 887 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION SITE OF POLARIZED GROWTH Ser-Thr protein kinase, member (with Ark1p and Prk1p) of the Ark kinase family; involved in endocytosis and actin cytoskeleton organization regulation of endocytosis|protein phosphorylation|actin cytoskeleton organization protein kinase activity cellular bud neck|cytoplasm
YDL183C YDL183C YDL183C hom Verified 0.660720429067114 0.254395810028048 no 1316 0.281190772452598 952 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene potassium ion transport|proton transport molecular_function integral to mitochondrial inner membrane
YGR101W YGR101W PCP1 hom Verified 0.658926414289678 0.254971511470308 no 1317 0.268126838754693 934 NA FT PROTEOLYSIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial serine protease required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases signal peptide processing|regulation of mitochondrion organization serine-type endopeptidase activity integral to membrane|mitochondrial inner membrane
YPL092W YPL092W SSU1 hom Verified 0.656787626951116 0.255658740567934 no 1318 0.260081036526227 849 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein sulfite transport sulfite transmembrane transporter activity integral to membrane|plasma membrane
YLR325C YLR325C RPL38 hom Verified 0.655166515645948 0.256180275173124 no 1319 0.274796542233005 921 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L38; homologous to mammalian ribosomal protein L38, no bacterial homolog cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YMR004W YMR004W MVP1 hom Verified 0.655100249719918 0.256201605661342 no 1320 0.273428478362361 960 NA FT PROTEIN LOCALIZATION|VACUOLAR TRANSPORT NUCLEUS Protein required for sorting proteins to the vacuole; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions; protein abundance increases in response to DNA replication stress protein targeting to vacuole phosphatidylinositol-3-phosphate binding nucleus|cytoplasm
YPL206C YPL206C PGC1 hom Verified 0.654965291035683 0.256245050679581 no 1321 0.232864981348331 790 NA FT LIPID METABOLISM|CARBOHYDRATE METABOLISM MITOCHONDRION Phosphatidyl Glycerol phospholipase C; regulates the phosphatidylglycerol (PG) content via a phospholipase C-type degradation mechanism; contains glycerophosphodiester phosphodiesterase motifs glycerophospholipid catabolic process|phosphatidylglycerol catabolic process phosphatidylglycerol phospholipase C activity mitochondrion|lipid particle
YGR071C YGR071C ENV11 hom Verified 0.654726272298793 0.256322003453844 no 1322 0.240619658478282 834 NA FT VACUOLAR PROTEIN PROCESSING NUCLEUS Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and fragmented vacuoles; deletion mutant has increased glycogen accumulation and displays elongated buds; green fluorescent protein (GFP)-fusion protein localizes to the nucleus vacuole organization|vacuolar protein processing molecular_function nucleus
YMR272W-B_p YMR272W-B YMR272W-B hom Uncharacterized 0.653083977455859 0.256851070562613 no 1323 0.213411358317135 747 NA Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YLR405W YLR405W DUS4 hom Verified 0.652903886569872 0.256909121599735 no 1324 0.245638302459258 814 NA FT RNA PROCESSING|OXIDATION-REDUCTION PROCESS Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p tRNA modification tRNA dihydrouridine synthase activity cellular_component
YFL016C YFL016C MDJ1 hom Verified 0.651227406462605 0.257449850635895 no 1325 0.325694139681081 1075 NA FT PROTEOLYSIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones protein refolding|response to heat|misfolded or incompletely synthesized protein catabolic process|mitochondrial genome maintenance|'de novo' protein folding unfolded protein binding|ATPase activator activity extrinsic to mitochondrial inner membrane|mitochondrion|mitochondrial matrix
YFR057W_p YFR057W YFR057W hom Uncharacterized 0.65096063411442 0.257535949431211 no 1326 0.271560177456367 943 NA Putative protein of unknown function biological_process molecular_function cellular_component
YIL030C YIL030C SSM4 hom Verified 0.650816072173605 0.257582611971797 no 1327 0.268116802893732 945 NA FT PROTEOLYSIS ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM UBIQUITIN LIGASE COMPLEX Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation ER-associated protein catabolic process ubiquitin-protein ligase activity nuclear envelope|integral to endoplasmic reticulum membrane|Doa10p ubiquitin ligase complex|integral to membrane|nuclear inner membrane
YKL185W YKL185W ASH1 hom Verified 0.650387323226061 0.257721031858322 no 1328 0.218665702201959 758 NA FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate Unknown RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|core promoter proximal region sequence-specific DNA binding Rpd3L-Expanded complex|nucleus|cellular bud|Rpd3L complex
YNL304W YNL304W YPT11 hom Verified 0.64759462219727 0.25862358823415 no 1329 0.267367444791146 901 NA FT SIGNALING|MITOCHONDRION ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH Rab family GTPase that interacts with the C-terminal tail domain of Myo2p; mediates distribution of mitochondria and endoplasmic reticuli to daughter cells mitochondrion inheritance|endoplasmic reticulum inheritance|Golgi inheritance|Golgi localization GTPase activity incipient cellular bud site|endoplasmic reticulum|cellular bud neck|cellular bud tip
YDR179C YDR179C CSN9 hom Verified 0.647091450694642 0.258786379048446 no 1330 0.255797943643183 835 NA FT SIGNALING NUCLEUS Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|cullin deneddylation molecular_function signalosome
YDR005C YDR005C MAF1 hom Verified 0.646247094783912 0.259059672184141 no 1331 0.273512799464649 948 NA FT NUCLEUS Highly conserved negative regulator of RNA polymerase III; binds to the N-terminal domain of the Rpc160p subunit of Pol III to prevent closed-complex formation; localization and activity are regulated by phosphorylation, mediated by TORC1, protein kinase A, and Sch9p; localizes to cytoplasm during vegetative growth and translocates to the nucleus and nucleolus under stress conditions negative regulation of transcription from RNA polymerase III promoter RNA polymerase III core binding nucleolus|nucleus|cytoplasm
YCL001W-B_p YCL001W-B YCL001W-B hom Uncharacterized 0.644190562964099 0.259725934829846 no 1332 0.277138089678953 924 NA Putative protein of unknown function; present in a region duplicated between chromosomes XIV and III; YCL001W-B has a paralog, DOM34, that arose from the whole genome duplication biological_process molecular_function cellular_component
YJR154W_p YJR154W YJR154W hom Uncharacterized 0.643502963666968 0.259948896166734 no 1333 0.261599710219772 865 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm biological_process molecular_function cytoplasm
YPL185W_d YPL185W YPL185W hom Dubious 0.643427023859278 0.259973526503621 no 1334 0.268556395953956 881 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C Unknown Unknown Unknown
YHR130C_d YHR130C YHR130C hom Dubious 0.643318901169131 0.260008597121565 no 1335 0.264860966457659 917 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPL098C YPL098C MGR2 hom Verified 0.64223616429719 0.260359927565084 no 1336 0.287860981256731 985 NA FT MITOCHONDRION Subunit of the TIM23 translocase complex; acts to couple Tim21p with the core Tim23 translocase; absolutely required for mitochondrial import of presequence-containing proteins at elevated temperature; required for viability of cells lacking the mitochondrial genome (petite-negative phenotype) protein import into mitochondrial matrix molecular_function mitochondrial inner membrane presequence translocase complex
YOL114C_p YOL114C YOL114C hom Uncharacterized 0.642153203458426 0.260386857086492 no 1337 0.271599470396249 948 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION Putative protein of unknown function with similarity to human ICT1 and prokaryotic factors that may function in translation termination; YOL114C is not an essential gene biological_process molecular_function cellular_component
YBR044C YBR044C TCM62 hom Verified 0.641840473253372 0.260488383840326 no 1338 0.196410076467822 690 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; putative chaperone mitochondrial respiratory chain complex II assembly unfolded protein binding mitochondrion|mitochondrial inner membrane
YLL014W YLL014W EMC6 hom Verified 0.640871180997144 0.260803190593219 no 1339 0.295513776916425 1023 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93 protein folding in endoplasmic reticulum molecular_function ER membrane protein complex|integral to membrane|endoplasmic reticulum
YIL015W YIL015W BAR1 hom Verified 0.640485579397823 0.260928480684656 no 1340 0.26220361690138 887 NA FT SIGNALING|PROTEOLYSIS Aspartyl protease secreted into the periplasmic space of mating type a cells, helps cells find mating partners, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|peptide catabolic process aspartic-type endopeptidase activity cell wall-bounded periplasmic space
YBR119W YBR119W MUD1 hom Verified 0.639535716835482 0.26123724304871 no 1341 0.286140402766857 997 NA FT RNA PROCESSING NUCLEUS U1 snRNP A protein, homolog of human U1-A; involved in nuclear mRNA splicing mRNA splicing, via spliceosome U1 snRNA binding|RNA binding U1 snRNP|U2-type prespliceosome
YGL251C YGL251C HFM1 hom Verified 0.639007908613417 0.261408893515031 no 1342 0.281082537069282 963 NA FT CELL CYCLE NUCLEUS Meiosis specific DNA helicase involved in the conversion of double-stranded breaks to later recombination intermediates and in crossover control; catalyzes the unwinding of Holliday junctions; has ssDNA and dsDNA stimulated ATPase activity meiosis|synapsis|DNA unwinding involved in replication|reciprocal meiotic recombination DNA helicase activity nucleus
YLR297W YLR297W YLR297W hom Verified 0.638687167623095 0.26151323116656 no 1343 0.256586175919567 882 NA Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; not an essential gene; induced by treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from nucleus to vacuole upon DNA replication stress; YLR297W has a paralog, YOR186W, that arose from the whole genome duplication biological_process molecular_function fungal-type vacuole
YMR177W YMR177W MMT1 hom Verified 0.637660009689798 0.261847511397309 no 1344 0.262834460896112 920 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt2p cellular iron ion homeostasis molecular_function mitochondrion|integral to membrane
YHL024W YHL024W RIM4 hom Verified 0.636937205258085 0.262082873546034 no 1345 0.281871373236565 978 NA FT CELL CYCLE Putative RNA-binding protein required for the expression of early and middle sporulation genes meiosis|reciprocal meiotic recombination|sporulation resulting in formation of a cellular spore|premeiotic DNA replication RNA binding cytoplasm
YOR180C YOR180C DCI1 hom Verified 0.635774315390225 0.262461765301196 no 1346 0.292655424301864 1006 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS Peroxisomal protein; identification as a delta(3,5)-delta(2,4)-dienoyl-CoA isomerase involved in fatty acid metabolism is disputed fatty acid beta-oxidation dodecenoyl-CoA delta-isomerase activity peroxisomal matrix
YKL202W_d YKL202W YKL202W hom Dubious 0.635201055854326 0.262648647359897 no 1347 0.22801733039284 783 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YKL006W YKL006W RPL14A hom Verified 0.633900059115003 0.263073023502985 no 1348 0.284974881781646 959 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L14A; N-terminally acetylated; homologous to mammalian ribosomal protein L14, no bacterial homolog; RPL14A has a paralog, RPL14B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YIL136W YIL136W OM45 hom Verified 0.633621181756993 0.263164036954187 no 1349 0.267958582382029 886 NA FT MITOCHONDRION Mitochondrial outer membrane protein of unknown function; major constituent of the outer membrane, located on the outer (cytosolic) face; protein abundance increases in response to DNA replication stress biological_process molecular_function mitochondrial outer membrane|mitochondrion|integral to mitochondrial outer membrane
YER045C YER045C ACA1 hom Verified 0.632627467530637 0.263488472828764 no 1350 0.253409671624774 882 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS ATF/CREB family basic leucine zipper (bZIP) transcription factor; binds as a homodimer to the ATF/CREB consensus sequence TGACGTCA; important for carbon source utilization; target genes include GRE2 and COS8; ACA1 has a paralog, CST6, that arose from the whole genome duplication positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YDR528W YDR528W HLR1 hom Verified 0.631676263034292 0.263799220900805 no 1351 0.240108684079465 788 NA FT CELL WALL ORG/BIOGENESIS Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A;
HLR1 has a paralog, LRE1, that arose from the whole genome duplication fungal-type cell wall organization molecular_function cytoplasm
YLR344W YLR344W RPL26A hom Verified 0.63084409626259 0.264071233832926 no 1352 0.250108791713874 816 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L26A; binds to 5.8S rRNA; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26A has a paralog, RPL26B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YCL029C YCL029C BIK1 hom Verified 0.630745594814422 0.264103440762973 no 1353 0.271974532650072 953 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION NUCLEUS|SITE OF POLARIZED GROWTH|CHROMOSOME|CYTOSKELETON KINETOCHORE Microtubule-associated protein, component of the interface between microtubules and kinetochore, involved in sister chromatid separation; essential in polyploid cells but not in haploid or diploid cells; ortholog of mammalian CLIP-170 karyogamy involved in conjugation with cellular fusion|mitotic anaphase B|negative regulation of microtubule polymerization|nuclear migration involved in conjugation with cellular fusion|mitotic spindle organization in nucleus|mitotic spindle elongation microtubule binding|protein homodimerization activity spindle microtubule|microtubule plus end|spindle pole body|cell cortex|condensed nuclear chromosome kinetochore|mating projection tip|kinetochore|spindle
YGL223C YGL223C COG1 hom Verified 0.629164556431971 0.264620665161251 no 1354 0.320746199046348 1067 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments retrograde transport, vesicle recycling within Golgi|intra-Golgi vesicle-mediated transport|CVT pathway molecular_function Golgi transport complex
YJR087W_d YJR087W YJR087W hom Dubious 0.629079413644793 0.264648533575085 no 1355 0.258541614370237 899 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified genes STE18 and ECM2 Unknown Unknown Unknown
YIL042C YIL042C PKP1 hom Verified 0.628957069411188 0.264688581151223 no 1356 0.245072570978551 825 NA FT SIGNALING|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION MITOCHONDRION Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p peptidyl-serine phosphorylation|protein phosphorylation|carbon utilization protein kinase activity|pyruvate dehydrogenase (acetyl-transferring) kinase activity mitochondrion
YCL036W YCL036W GFD2 hom Verified 0.628571361267584 0.264814857180907 no 1357 0.265655576093667 915 NA Protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; GFD2 has a paralog, YDR514C, that arose from the whole genome duplication biological_process molecular_function cellular_component
YER067C-A_d YER067C-A YER067C-A hom Dubious 0.628310234091906 0.264900364339508 no 1358 0.238592534926495 789 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W Unknown Unknown Unknown
YPR078C_p YPR078C YPR078C hom Uncharacterized 0.627570453093633 0.265142684810294 no 1359 0.2497507982093 858 NA Putative protein of unknown function; possible role in DNA metabolism and/or in genome stability; expression is heat-inducible biological_process molecular_function cellular_component
YLR283W_p YLR283W YLR283W hom Uncharacterized 0.627429394621353 0.265188902281467 no 1360 0.247596504323364 839 NA FT MITOCHONDRION Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR283W is not an essential gene biological_process molecular_function mitochondrion
YCR088W YCR088W ABP1 hom Verified 0.627264476935291 0.265242942353944 no 1361 0.252964719755479 838 NA FT PROTEIN LOCALIZATION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization; phosphorylation within its PRR (Proline-Rich Region), mediated by Cdc28p and Pho85p, protects Abp1p from proteolysis mediated by its own PEST sequences protein localization|actin cortical patch assembly actin filament binding cell cortex|mating projection tip|cytoplasm|actin cortical patch
YKL157W YKL157W APE2 hom Verified 0.627053062863502 0.265312226495353 no 1362 0.273731195214117 896 NA FT PROTEOLYSIS MITOCHONDRION Aminopeptidase yscII; may have a role in obtaining leucine from dipeptide substrates; APE2 has a paralog, AAP1, that arose from the whole genome duplication peptide catabolic process metalloaminopeptidase activity mitochondrion|extracellular region|cell wall-bounded periplasmic space
YDR484W YDR484W VPS52 hom Verified 0.623725509377507 0.266403933631889 no 1363 0.324613518476581 1084 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT GOLGI APPARATUS|CYTOSKELETON Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin actin filament-based process|Golgi to vacuole transport|retrograde transport, endosome to Golgi protein binding Golgi apparatus|GARP complex
YGR229C YGR229C SMI1 hom Verified 0.623263506906562 0.266555687360434 no 1364 0.305695911049204 1048 NA FF|FT CELL CYCLE|CELL WALL ORG/BIOGENESIS NUCLEUS|SITE OF POLARIZED GROWTH Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity regulation of mitotic cell cycle|regulation of fungal-type cell wall biogenesis molecular_function incipient cellular bud site|cellular bud neck|mating projection tip
YML063W YML063W RPS1B hom Verified 0.623056398862167 0.266623730228069 no 1365 0.285027199942418 971 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal protein 10 (rp10) of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1B has a paralog, RPS1A, that arose from the whole genome duplication cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit|90S preribosome
YDL188C YDL188C PPH22 hom Verified 0.622494798041111 0.266808281634524 no 1366 0.265702909325098 884 NA FT CELL CYCLE|TRANSLATION|CELL DIVISION|CYTOSKELETON ORGANIZATION NUCLEUS|CHROMOSOME Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; PPH22 has a paralog, PPH21, that arose from the whole genome duplication actin filament organization|budding cell bud growth|G1/S transition of mitotic cell cycle|protein dephosphorylation|mitotic cell cycle spindle assembly checkpoint|regulation of translation protein serine/threonine phosphatase activity condensed nuclear chromosome, centromeric region
YFL023W YFL023W BUD27 hom Verified 0.622414802053902 0.266834574902899 no 1367 0.267279536097938 943 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION RIBOSOME Unconventional prefoldin protein involved in translation initiation; mutants have inappropriate expression of nutrient sensitive genes due to translational derepression of Gcn4p transcription factor; diploid mutants show random budding; ortholog of human URI/RMP formation of translation preinitiation complex molecular_function cytosolic ribosome|cytoplasm
YDR475C YDR475C JIP4 hom Verified 0.619891293747403 0.267664679029625 no 1368 0.260566615938233 885 NA Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence biological_process molecular_function cellular_component
YNL236W YNL236W SIN4 hom Verified 0.618527405390387 0.268113869179766 no 1369 0.307576154837611 1053 NA FF|FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both postive and negative transcriptional regulation; dispensible for basal transcription negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II activating transcription factor binding core mediator complex
YNL133C YNL133C FYV6 hom Verified 0.618258045866026 0.268202626303487 no 1370 0.302045719282138 1043 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Protein of unknown function, required for survival upon exposure to K1 killer toxin; proposed to regulate double-strand break repair via non-homologous end-joining double-strand break repair via nonhomologous end joining molecular_function nucleus
YER097W_d YER097W YER097W hom Dubious 0.618169778673344 0.268231714595029 no 1371 0.310678566924591 1051 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YNL206C YNL206C RTT106 hom Verified 0.616942590562137 0.268636296560585 no 1372 0.281349712889773 981 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Histone chaperone, involved in regulation of chromatin structure in both transcribed and silenced chromosomal regions; affects transcriptional elongation; has a role in regulation of Ty1 transposition DNA replication-independent nucleosome assembly|negative regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|DNA replication-dependent nucleosome assembly|heterochromatin assembly involved in chromatin silencing double-stranded DNA binding|histone binding nucleus
YDR158W YDR158W HOM2 hom Verified 0.616416228290465 0.268809922709404 no 1373 0.298776649590417 1035 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS NUCLEUS Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis methionine biosynthetic process|threonine biosynthetic process|homoserine biosynthetic process aspartate-semialdehyde dehydrogenase activity nucleus|plasma membrane|cytoplasm
YNL162W-A_p YNL162W-A YNL162W-A hom Uncharacterized 0.615000430860467 0.269277217941934 no 1374 0.25948806839767 885 NA FT NUCLEUS Putative protein of unknown function; identified by homology biological_process molecular_function nucleus|cytoplasm
YAR027W YAR027W UIP3 hom Verified 0.613898143326071 0.269641318594795 no 1375 0.266087009990938 885 NA FT ENDOMEMBRANE SYSTEM|NUCLEUS|PLASMA MEMBRANE Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family biological_process molecular_function nuclear envelope
YCR033W YCR033W SNT1 hom Verified 0.613574046482457 0.269748419115376 no 1376 0.271835003932486 931 NA FT CELL CYCLE|CHROMATIN ORGANIZATION|SIGNALING NUCLEUS|CHROMOSOME Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein; mutant has increased aneuploidy tolerance negative regulation of meiosis|regulation of transcription, DNA-dependent|histone deacetylation|positive regulation of stress-activated MAPK cascade molecular_function Rpd3L-Expanded complex|Set3 complex
YHR178W YHR178W STB5 hom Verified 0.613289736242623 0.269842389357382 no 1377 0.266116573751843 896 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO OXIDATIVE STRESS NUCLEUS Transcription factor, involved in regulating multidrug resistance and oxidative stress response; forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that interacts with a pleiotropic drug resistance element in vitro response to xenobiotic stimulus|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|transcription, DNA-dependent sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nucleus
YAL007C YAL007C ERP2 hom Verified 0.609701644249444 0.271029732579043 no 1378 0.273343238802337 933 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein that forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles ER to Golgi vesicle-mediated transport molecular_function ER to Golgi transport vesicle
YLR280C_d YLR280C YLR280C hom Dubious 0.609383238731929 0.271135222588659 no 1379 0.241054829739218 795 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YER134C YER134C YER134C hom Verified 0.608633447414701 0.27138371462428 no 1380 0.270030875573604 936 NA FT NUCLEUS Magnesium-dependent acid phosphatase, member of the haloacid dehalogenase superfamily; non-essential gene biological_process acid phosphatase activity nucleus|cytoplasm
YMR002W YMR002W MIC17 hom Verified 0.608165601129076 0.271538823340021 no 1381 0.278970239745212 972 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS|MITOCHONDRION Mitochondrial intermembrane space protein; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress aerobic respiration molecular_function nucleus|cytoplasm|mitochondrial intermembrane space
YIL018W YIL018W RPL2B hom Verified 0.607687185720854 0.271697481765001 no 1382 0.251049770526065 842 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L2B; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2B has a paralog, RPL2A, that arose from the whole genome duplication; expression is upregulated at low temperatures cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YAR018C YAR018C KIN3 hom Verified 0.605297964663434 0.272490516774601 no 1383 0.290593958698633 977 NA FT PROTEIN PHOSPHORYLATION|CHROMOSOME SEGREGATION Nonessential serine/threonine protein kinase; possible role in DNA damage response chromosome segregation|protein phosphorylation protein kinase activity cellular_component
YJR146W_p YJR146W YJR146W hom Uncharacterized 0.60355207812212 0.273070740832212 no 1384 0.262032341966124 876 NA Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps HMS2 biological_process molecular_function cellular_component
YKL221W YKL221W MCH2 hom Verified 0.603409288953243 0.273118222143991 no 1385 0.287697237105334 978 NA Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport transport monocarboxylic acid transmembrane transporter activity|transporter activity integral to membrane|membrane
YOR190W YOR190W SPR1 hom Verified 0.601750772686138 0.273670023828036 no 1386 0.274613373545786 992 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance ascospore formation glucan exo-1,3-beta-glucosidase activity fungal-type cell wall|ascospore wall
YPL192C YPL192C PRM3 hom Verified 0.601701906184846 0.273686290466486 no 1387 0.25742185759949 910 NA FT MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON Pheromone-regulated protein required for nuclear envelope fusion during karyogamy; localizes to the outer face of the nuclear membrane; interacts with Kar5p at the spindle pole body karyogamy involved in conjugation with cellular fusion|nuclear membrane fusion involved in karyogamy molecular_function nuclear envelope|spindle pole body|extrinsic to nuclear outer membrane
YCR049C_d YCR049C YCR049C hom Dubious 0.60150269210019 0.273752609626913 no 1388 0.296280986512705 1012 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR108C YLR108C YLR108C hom Verified 0.601433867439582 0.273775523477129 no 1389 0.289491222218642 979 NA FT NUCLEUS Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene; protein abundance increases in response to DNA replication stress; YLR108C has a paralog, YDR132C, that arose from the whole genome duplication biological_process molecular_function nucleus
YJL136C YJL136C RPS21B hom Verified 0.601431153741914 0.273776426970137 no 1390 0.283287802406608 933 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|cytoplasmic translation|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit
YIL099W YIL099W SGA1 hom Verified 0.600417755934556 0.274113928643576 no 1391 0.269493866791512 910 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation ascospore formation|glycogen catabolic process glucan 1,4-alpha-glucosidase activity fungal-type vacuole
YPL135W YPL135W ISU1 hom Verified 0.599288943006478 0.274490109965302 no 1392 0.281681960011641 962 NA FT RNA PROCESSING|ION HOMEOSTASIS|ION HOMEOSTASIS|COFACTOR METABOLISM MITOCHONDRION Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable cellular iron ion homeostasis|iron-sulfur cluster assembly|tRNA wobble uridine modification ferrous iron binding mitochondrion|mitochondrial matrix
YAR020C YAR020C PAU7 hom Verified 0.598200505601435 0.274853077061476 no 1393 0.277342962038403 925 NA Member of the seripauperin multigene family, active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme biological_process molecular_function cellular_component
YNL297C YNL297C MON2 hom Verified 0.598017640985241 0.274914081114864 no 1394 0.316270690255862 1052 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Peripheral membrane protein with a role in endocytosis and vacuole integrity, interacts with Arl1p and localizes to the endosome; member of the Sec7p family of proteins transport|endocytosis|protein targeting to vacuole|Golgi to endosome transport guanyl-nucleotide exchange factor activity cytosol|endosome|trans-Golgi network|extrinsic to membrane
YJR139C YJR139C HOM6 hom Verified 0.597598513644119 0.27505392811991 no 1395 0.292648351743162 1019 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS NUCLEUS Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions threonine biosynthetic process|methionine biosynthetic process|homoserine biosynthetic process homoserine dehydrogenase activity nucleus|cytoplasm
YDR171W YDR171W HSP42 hom Verified 0.596330822983924 0.275477121891275 no 1396 0.252639756902805 846 NA FT CYTOSKELETON ORGANIZATION CYTOSKELETON Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress cytoskeleton organization unfolded protein binding cytoskeleton|chaperonin-containing T-complex|cytoplasm
YDL125C YDL125C HNT1 hom Verified 0.595692823881328 0.275690226525541 no 1397 0.265949333425532 915 NA FT NUCLEOTIDE METABOLISM NUCLEUS Adenosine 5'-monophosphoramidase; interacts physically and genetically with Kin28p, a CDK and TFIIK subunit, and genetically with CAK1; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins and similar to Hint; protein abundance increases in response to DNA replication stress nucleotide metabolic process hydrolase activity|nucleotide binding nucleus|cytoplasm
YJL116C YJL116C NCA3 hom Verified 0.594950709295051 0.275938209752162 no 1398 0.262050620258803 890 NA FT MITOCHONDRION ORGANIZATION MITOCHONDRION Protein involved in mitochondrion organization; functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; member of the SUN family; expression induced in cells treated with the mycotoxin patulin; NCA3 has a paralog, UTH1, that arose from the whole genome duplication mitochondrion organization molecular_function cellular_component
YHR151C YHR151C MTC6 hom Verified 0.592048927461674 0.276908912678051 no 1399 0.280158919041732 981 NA Protein of unknown function; mtc6 is synthetically sick with cdc13-1 biological_process molecular_function cellular_component
YJR111C_p YJR111C YJR111C hom Uncharacterized 0.591348848020067 0.277143353098086 no 1400 0.269748298608319 944 NA FT OXIDATION-REDUCTION PROCESS MITOCHONDRION Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria biological_process molecular_function mitochondrion
YPL136W_d YPL136W YPL136W hom Dubious 0.590582669167665 0.277400039937504 no 1401 0.281427076105406 979 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene GIP3/YPL137C Unknown Unknown Unknown
YGL219C YGL219C MDM34 hom Verified 0.59056382213382 0.277406355574578 no 1402 0.317309903725081 1072 NA FT MITOCHONDRION ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION Mitochondrial component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth mitochondrion organization|phospholipid transport molecular_function mitochondrial outer membrane|ERMES complex|mitochondrion|cytoplasm
YLR395C YLR395C COX8 hom Verified 0.590407327821091 0.277458799500857 no 1403 0.291200672922117 1010 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain mitochondrial electron transport, cytochrome c to oxygen cytochrome-c oxidase activity mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YPR066W YPR066W UBA3 hom Verified 0.590222290928598 0.277520814786846 no 1404 0.286290921867025 985 NA Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern protein neddylation NEDD8 activating enzyme activity cytoplasm
YOR290C YOR290C SNF2 hom Verified 0.589804396037104 0.277660897566968 no 1405 0.349032647710325 1182 NA FF|FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS NUCLEUS RSC COMPLEX Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p cellular alcohol catabolic process|ATP-dependent chromatin remodeling|double-strand break repair|strand invasion|positive regulation of mating type switching|sucrose catabolic process|positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation|nucleosome mobilization|chromatin remodeling|DNA-dependent DNA replication|positive regulation of transcription from RNA polymerase II promoter histone acetyl-lysine binding|RNA polymerase II activating transcription factor binding|DNA-dependent ATPase activity|nucleosomal DNA binding SWI/SNF complex|nucleus
YER179W YER179W DMC1 hom Verified 0.58944358010384 0.277781874656837 no 1406 0.256935353749216 867 NA FT CELL CYCLE NUCLEUS|CHROMOSOME Meiosis-specific protein required for repair of double-strand breaks and pairing between homologous chromosomes; homolog of Rad51p and the bacterial RecA protein; binds ssDNA and dsDNA, forms helical filaments; stimulated by Rdh54p meiosis|reciprocal meiotic recombination|meiotic joint molecule formation double-stranded DNA binding|single-stranded DNA binding condensed nuclear chromosome|nucleus
YOR177C YOR177C MPC54 hom Verified 0.589384411438559 0.27780171562971 no 1407 0.287759629012399 980 NA FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION NUCLEUS|CYTOSKELETON Component of the meiotic outer plaque, a membrane-organizing center which is assembled on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; potential Cdc28p substrate ascospore wall assembly|vesicle docking structural molecule activity spindle pole body
YBR151W YBR151W APD1 hom Verified 0.588929020421926 0.277954444623791 no 1408 0.272547217628101 948 NA FT NUCLEUS Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus biological_process molecular_function nucleus|cytoplasm
YGR043C YGR043C NQM1 hom Verified 0.587958581686166 0.278280046912005 no 1409 0.271198903589243 944 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS NUCLEUS Transaldolase of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift biological_process sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity nucleus
YML009W-B_d YML009W-B YML009W-B hom Dubious 0.587816143924875 0.278327853374643 no 1410 0.282890062233139 996 NA Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition Unknown Unknown Unknown
YDR266C YDR266C HEL2 hom Verified 0.586875297828287 0.278643730570671 no 1411 0.285748475098707 961 NA RING finger ubiquitin ligase (E3); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; computational analysis suggests a role as a transcription factor biological_process molecular_function ribosome|cytoplasm
YBR271W YBR271W EFM2 hom Verified 0.586660771745681 0.27871577942566 no 1412 0.312729541730762 1034 NA S-adenosylmethionine-dependent methyltransferase; methylates translation elongation factors EF2 (Eft1p and Eft2p) and EF3A (Yef3p); belongs to the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; predicted to be involved in ribosome biogenesis peptidyl-lysine methylation S-adenosylmethionine-dependent methyltransferase activity|protein-lysine N-methyltransferase activity cytoplasm
YNL155W YNL155W YNL155W hom Verified 0.586207007593518 0.278868206561199 no 1413 0.260010744227268 917 NA FT NUCLEUS Protein of unknown function; contains a DHHC domain and an AN1-type zinc finger; predicted to have thiol-disulfide oxidoreductase active site; transcriptionally regulated by Rpn4p along with proteasome subunit genes; putative ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus|cytoplasm
YKL181W YKL181W PRS1 hom Verified 0.585259428261949 0.2791866453917 no 1414 0.278587460993436 980 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes fungal-type cell wall organization|5-phosphoribose 1-diphosphate biosynthetic process ribose phosphate diphosphokinase activity cytoplasm
YKR013W YKR013W PRY2 hom Verified 0.58459709206447 0.279409331723672 no 1415 0.303633099674391 1057 NA Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY1; may be involved in detoxification of hydrophobic compounds; PRY2 has a paralog, PRY1, that arose from the whole genome duplication biological_process molecular_function extracellular region|fungal-type vacuole
YLR412C-A_p YLR412C-A YLR412C-A hom Uncharacterized 0.584110262716871 0.27957306528755 no 1416 0.280972800844418 955 NA Putative protein of unknown function biological_process molecular_function cellular_component
YLR420W YLR420W URA4 hom Verified 0.583330955879784 0.27983526367715 no 1417 0.290232367329179 1008 NA FT NUCLEOTIDE METABOLISM NUCLEUS Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate 'de novo' pyrimidine nucleobase biosynthetic process|pyrimidine nucleotide biosynthetic process dihydroorotase activity nucleus|cytoplasm
YEL036C YEL036C ANP1 hom Verified 0.583319152171956 0.279839235960626 no 1418 0.319490192724283 1076 NA FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol protein N-linked glycosylation alpha-1,6-mannosyltransferase activity|mannosyltransferase activity alpha-1,6-mannosyltransferase complex|Golgi cis cisterna
YOR078W YOR078W BUD21 hom Verified 0.58298659886555 0.279951160847445 no 1419 0.271293129439926 905 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA; originally isolated as bud-site selection mutant that displays a random budding pattern endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) snoRNA binding small-subunit processome|nucleolus|90S preribosome
YOL126C YOL126C MDH2 hom Verified 0.58265037186989 0.280064344221698 no 1420 0.273949196554656 932 NA FT PROTEIN LOCALIZATION|KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM|PEROXISOME ORGANIZATION Cytoplasmic malate dehydrogenase, one of three isozymes that catalyze interconversion of malate and oxaloacetate; involved in the glyoxylate cycle and gluconeogenesis during growth on two-carbon compounds; interacts with Pck1p and Fbp1 protein import into peroxisome matrix|gluconeogenesis|malate metabolic process L-malate dehydrogenase activity cytosol|cytoplasm
YDL202W YDL202W MRPL11 hom Verified 0.582087747521471 0.280253788847697 no 1421 0.285026269933593 978 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YKR090W YKR090W PXL1 hom Verified 0.5817130582513 0.280379987149433 no 1422 0.283629842013594 1000 NA FT SIGNALING SITE OF POLARIZED GROWTH Protein that localizes to sites of polarized growth; required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; contains LIM domains and has similarity to metazoan paxillin; relocalizes from bud neck to cytoplasm upon DNA replication stress maintenance of cell polarity|regulation of Rho protein signal transduction Rho GDP-dissociation inhibitor activity incipient cellular bud site|cellular bud|mating projection tip|cellular bud neck|cytoplasm|cellular bud tip
YHR091C YHR091C MSR1 hom Verified 0.581606967839016 0.280415724234884 no 1423 0.268381252627942 956 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial arginyl-tRNA synthetase; mutations in human ortholog are associated with pontocerebellar hypoplasia type 6 arginyl-tRNA aminoacylation|mitochondrial arginyl-tRNA aminoacylation|mitochondrial translation arginine-tRNA ligase activity mitochondrion
YGR281W YGR281W YOR1 hom Verified 0.57995902240516 0.28097112588588 no 1424 0.292155063220027 992 NA FT NUCLEOTIDE METABOLISM PLASMA MEMBRANE Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter mediates export of many different organic anions including oligomycin; similar to human cystic fibrosis transmembrane receptor (CFTR) transport|response to drug xenobiotic-transporting ATPase activity integral to membrane|plasma membrane
YMR223W YMR223W UBP8 hom Verified 0.57938098122873 0.281166067072829 no 1425 0.261572330292412 897 NA FT CHROMATIN ORGANIZATION|PROTEOLYSIS NUCLEUS HISTONE ACETYLTRANSFERASE Ubiquitin-specific protease that is a component of the SAGA (Spt-Ada-Gcn5-Acetyltransferase) acetylation complex; required for SAGA-mediated deubiquitination of histone H2B histone H3-K4 methylation|histone deubiquitination|histone H3-K79 methylation ubiquitin-specific protease activity|protein complex scaffold DUBm complex|SLIK (SAGA-like) complex|SAGA complex
YDR313C YDR313C PIB1 hom Verified 0.578518569264546 0.281457032105773 no 1426 0.280648366546831 953 NA RING-type ubiquitin ligase of the endosomal and vacuolar membranes, binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain protein ubiquitination ubiquitin-protein ligase activity|phosphatidylinositol-3-phosphate binding fungal-type vacuole membrane|late endosome
YLR188W YLR188W MDL1 hom Verified 0.57666566106624 0.282082666852152 no 1427 0.291233125291755 980 NA FT NUCLEOTIDE METABOLISM MITOCHONDRION Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, mediates export of peptides generated upon proteolysis of mitochondrial proteins, plays a role in the regulation of cellular resistance to oxidative stress oligopeptide transport|oligopeptide export from mitochondrion ATPase activity|oligopeptide-transporting ATPase activity mitochondrion|integral to membrane|mitochondrial inner membrane
YOR038C YOR038C HIR2 hom Verified 0.573924624324084 0.283009404494564 no 1428 0.275884824038271 936 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p DNA replication-independent nucleosome assembly|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter nucleosome binding|transcription corepressor activity|DNA binding HIR complex|nucleus
YEL003W YEL003W GIM4 hom Verified 0.573826233600912 0.283042697305485 no 1429 0.276994153861928 948 NA FT PROTEIN COMPLEX ORG/BIOGENESIS Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it tubulin complex assembly tubulin binding prefoldin complex|cytoplasm
YLR120C YLR120C YPS1 hom Verified 0.573687569389475 0.283089620787873 no 1430 0.300370915011414 1026 NA FT CELL WALL ORG/BIOGENESIS|PROTEOLYSIS PLASMA MEMBRANE Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor fungal-type cell wall organization|protein processing aspartic-type endopeptidase activity fungal-type cell wall
YOL140W YOL140W ARG8 hom Verified 0.572631456271965 0.283447128201521 no 1431 0.269795284688454 893 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine arginine biosynthetic process|ornithine biosynthetic process N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity mitochondrion|mitochondrial matrix
YPL056C_p YPL056C LCL1 hom Uncharacterized 0.567109874842326 0.285319767136821 no 1432 0.281254255854839 996 NA FT PLASMA MEMBRANE Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan biological_process molecular_function cellular_component
YKL201C YKL201C MNN4 hom Verified 0.566853541412203 0.285406845321947 no 1433 0.281191110880028 961 NA FT CARBOHYDRATE METABOLISM Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication protein O-linked glycosylation|protein N-linked glycosylation|response to stress molecular_function membrane
YDR268W YDR268W MSW1 hom Verified 0.56623803386499 0.285615989026818 no 1434 0.301175243489544 1016 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial tryptophanyl-tRNA synthetase mitochondrial tryptophanyl-tRNA aminoacylation tryptophan-tRNA ligase activity mitochondrion
YPL256C YPL256C CLN2 hom Verified 0.564236781450911 0.286296499464565 no 1435 0.275080484364198 925 NA FT CELL CYCLE|SIGNALING|CELL DIVISION|PROTEIN PHOSPHORYLATION NUCLEUS G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p) regulation of cyclin-dependent protein kinase activity|re-entry into mitotic cell cycle after pheromone arrest cyclin-dependent protein kinase regulator activity cyclin-dependent protein kinase holoenzyme complex|nucleus|cytoplasm
YPL186C YPL186C UIP4 hom Verified 0.56420310390198 0.286307957838451 no 1436 0.311255360457369 1060 NA FT ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION Protein that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope biological_process molecular_function mitochondrial outer membrane|nuclear envelope|endoplasmic reticulum
YKL062W YKL062W MSN4 hom Verified 0.563414631834299 0.286576288011314 no 1437 0.286017028132077 967 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|RESPONSE TO OXIDATIVE STRESS NUCLEUS Transcriptional activator; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression; MSN4 has a paralog, MSN2, that arose from the whole genome duplication positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription from RNA polymerase II promoter in response to a hypotonic environment|positive regulation of transcription from RNA polymerase II promoter in response to alkalinity|positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation|positive regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation|positive regulation of transcription from RNA polymerase II promoter in response to acidity|chromatin remodeling|regulation of replicative cell aging by regulation of transcription from RNA polymerase II promoter in response to caloric restriction|positive regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide|positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance|positive regulation of transcription from RNA polymerase II promoter in response to increased salt|cellular response to acidity|positive regulation of transcription from RNA polymerase II promoter in response to freezing|positive regulation of transcription from RNA polymerase II promoter in response to ethanol|replicative cell aging|age-dependent response to oxidative stress involved in chronological cell aging|positive regulation of transcription from RNA polymerase II promoter in response to hydrostatic pressure|positive regulation of transcription from RNA polymerase II promoter in response to nitrosative stress|positive regulation of transcription from RNA polymerase II promoter in response to cold|positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding cytosol|nucleus
YNL085W YNL085W MKT1 hom Verified 0.563394619341474 0.286583100147812 no 1438 0.283124347984017 948 NA FT RESPONSE TO DNA DAMAGE|TRANSLATION Protein that forms a complex with Pbp1p; complex may mediate posttranscriptional regulation of HO; involved in propagation of M2 dsRNA satellite of L-A virus; allelic variation affects mitochondrial genome stability, drug resistance, and more; forms cytoplasmic foci upon DNA replication stress positive regulation of translation|interspecies interaction between organisms|response to DNA damage stimulus nuclease activity polysome|cytoplasm
YJL007C_d YJL007C YJL007C hom Dubious 0.563351442758736 0.286597797467789 no 1439 0.284343878096644 966 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YJL036W YJL036W SNX4 hom Verified 0.562616636628919 0.28684798046337 no 1440 0.321913851448572 1087 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT Sorting nexin, involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX phosphoinositide-binding domain; forms complexes with Snx41p and with Atg20p piecemeal microautophagy of nucleus|mitochondrion degradation|early endosome to Golgi transport|CVT pathway|protein targeting to vacuole phosphatidylinositol-3-phosphate binding cytosol|pre-autophagosomal structure|extrinsic to membrane|early endosome
YBR005W YBR005W RCR1 hom Verified 0.562604728948409 0.286852035580975 no 1441 0.271312213175873 945 NA FT VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein of the ER membrane involved in cell wall chitin deposition; may function in the endosomal-vacuolar trafficking pathway, helping determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR1 has a paralog, RCR2, that arose from the whole genome duplication fungal-type cell wall organization|vesicle-mediated transport molecular_function integral to endoplasmic reticulum membrane
YER182W_p YER182W FMP10 hom Uncharacterized 0.56213794272597 0.28701101934532 no 1442 0.283345751036262 976 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YDR314C YDR314C RAD34 hom Verified 0.561102143214004 0.287363953596633 no 1443 0.296747605470559 946 NA FT RESPONSE TO DNA DAMAGE NUCLEUS Protein involved in nucleotide excision repair (NER); homologous to RAD4 nucleotide-excision repair molecular_function nucleus
YML128C YML128C MSC1 hom Verified 0.560351672271341 0.287619794313525 no 1444 0.295033256652983 978 NA FT CELL CYCLE ENDOPLASMIC RETICULUM|MITOCHONDRION Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated reciprocal meiotic recombination molecular_function mitochondrion|endoplasmic reticulum|plasma membrane
YMR257C YMR257C PET111 hom Verified 0.559795450773984 0.28780948349625 no 1445 0.302871237619079 1036 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membrane mitochondrial respiratory chain complex IV biogenesis|positive regulation of mitochondrial translation translation regulator activity mitochondrion|mitochondrial inner membrane
YHR064C YHR064C SSZ1 hom Verified 0.559738187652822 0.287829015392366 no 1446 0.247342918973806 889 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP cytoplasmic translation|regulation of translational fidelity|rRNA processing unfolded protein binding polysome|cytoplasm
YHR187W YHR187W IKI1 hom Verified 0.559056324204705 0.28806164051069 no 1447 0.283716022039308 950 NA FT RNA PROCESSING NUCLEUS Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin tRNA modification tRNA binding|ATPase activity Elongator holoenzyme complex|nucleus|cytoplasm
YJL095W YJL095W BCK1 hom Verified 0.55772180509294 0.288517182790022 no 1448 0.355442973009554 1207 NA FF|FT SIGNALING|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION SITE OF POLARIZED GROWTH Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p intracellular protein kinase cascade|endoplasmic reticulum unfolded protein response|peroxisome degradation|establishment of cell polarity|protein phosphorylation|response to acid|response to nutrient protein kinase activity|MAP kinase kinase kinase activity intracellular|mating projection tip
YIR020W-A_d YIR020W-A YIR020W-A hom Dubious 0.555785078214583 0.289178893729076 no 1449 0.302074953321001 1059 NA Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data Unknown Unknown Unknown
YGR106C YGR106C VOA1 hom Verified 0.554618525161724 0.289577807578791 no 1450 0.34802253383711 1157 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Endoplasmic reticulum protein that functions, together with other assembly factors, in assembly of the V0 sector of the vacuolar ATPase (V-ATPase); null mutation enhances the V-ATPase deficiency of a vma21 mutant impaired in ER retrieval protein complex assembly molecular_function fungal-type vacuole membrane|endoplasmic reticulum membrane
YOL085C_d YOL085C YOL085C hom Dubious 0.55424264899 0.289706397004654 no 1451 0.289984208882201 984 NA Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A Unknown Unknown Unknown
YBL010C_p YBL010C YBL010C hom Uncharacterized 0.554149640439802 0.289738219906349 no 1452 0.287006462941382 999 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles biological_process molecular_function clathrin-coated vesicle
YER113C YER113C TMN3 hom Verified 0.554140461900069 0.289741360435231 no 1453 0.284044212183855 999 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn2p; member of Transmembrane Nine family with 9 transmembrane segments; localizes to Golgi; induced by 8-methoxypsoralen plus UVA irradiation cellular copper ion homeostasis|vacuolar transport|pseudohyphal growth|invasive growth in response to glucose limitation molecular_function COPI-coated vesicle|integral to membrane|Golgi apparatus
YFL042C_p YFL042C YFL042C hom Uncharacterized 0.554130497136084 0.289744769996664 no 1454 0.295520648579337 986 NA Putative protein of unknown function; YFL042C is not an essential gene biological_process molecular_function cellular_component
YDL080C YDL080C THI3 hom Verified 0.553707990636491 0.28988935289408 no 1455 0.279747691198713 941 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Probable alpha-ketoisocaproate decarboxylase, may have a role in catabolism of amino acids to long-chain and complex alcohols; required for expression of enzymes involved in thiamine biosynthesis regulation of thiamine biosynthetic process|branched-chain amino acid catabolic process to alcohol via Ehrlich pathway|positive regulation of transcription from RNA polymerase II promoter|leucine catabolic process carboxy-lyase activity cytosol|nucleus
YJR075W YJR075W HOC1 hom Verified 0.55023342405086 0.291079640583622 no 1456 0.281044869672894 983 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM GOLGI APPARATUS Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele cell wall mannoprotein biosynthetic process|substituted mannan metabolic process alpha-1,6-mannosyltransferase activity|transferase activity, transferring glycosyl groups alpha-1,6-mannosyltransferase complex
YJL105W YJL105W SET4 hom Verified 0.550115321900707 0.291120139105447 no 1457 0.297819334958113 1033 NA FT CHROMATIN ORGANIZATION Protein of unknown function, contains a SET domain; SET4 has a paralog, SET3, that arose from the whole genome duplication biological_process molecular_function cellular_component
YGR061C YGR061C ADE6 hom Verified 0.550070700762307 0.291135440867798 no 1458 0.282486584643119 957 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM Formylglycinamidine-ribonucleotide (FGAM)-synthetase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway 'de novo' IMP biosynthetic process|purine nucleotide biosynthetic process phosphoribosylformylglycinamidine synthase activity cytoplasm
YOR118W YOR118W RTC5 hom Verified 0.549584215095532 0.291302293967439 no 1459 0.312929931697099 1072 NA Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity biological_process molecular_function cytoplasm
YDR206W YDR206W EBS1 hom Verified 0.549412453088551 0.291361214939807 no 1460 0.298605961721736 985 NA FT TRANSLATION NUCLEUS|CHROMOSOME Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors negative regulation of translation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay molecular_function cytoplasmic mRNA processing body|cytoplasm
YIL058W_d YIL058W YIL058W hom Dubious 0.547985684151273 0.291850866362605 no 1461 0.294910636906796 1003 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YIR043C YIR043C YIR043C hom pseudogene 0.547860421067962 0.291893873574608 no 1462 0.292705415018636 995 NA Possible pseudogene in strain S288C; YIR043C and the adjacent ORF, YIR044C, together may encode a non-functional member of the conserved, often subtelomerically-encoded Cos protein family biological_process molecular_function cellular_component
YOL002C YOL002C IZH2 hom Verified 0.547126675382189 0.292145853481516 no 1463 0.290610842485611 1001 NA FT KETONE METABOLISM|LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc response to zinc ion|cellular zinc ion homeostasis|response to toxin|cellular lipid metabolic process protein binding|metal ion binding integral to membrane|plasma membrane|membrane
YMR224C YMR224C MRE11 hom Verified 0.546563081563099 0.292339469248022 no 1464 0.30211762088669 1017 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION Subunit of the MRX complex with Rad50p and Xrs2p; complex functions in repair of DNA double-strand breaks and in telomere stability; exhibits nuclease activity that appears to be required for MRX function; widely conserved; forms nuclear foci upon DNA replication stress DNA repair|meiotic DNA double-strand break formation|double-strand break repair via nonhomologous end joining|base-excision repair|ascospore formation|meiotic DNA double-strand break processing|double-strand break repair via break-induced replication|regulation of transcription during meiosis 3'-5' exonuclease activity|protein complex scaffold|double-stranded telomeric DNA binding|adenylate kinase activity|telomeric DNA binding|single-stranded telomeric DNA binding|endodeoxyribonuclease activity|G-quadruplex DNA binding|endonuclease activity mitochondrion|nucleus|Mre11 complex
YPL168W_p YPL168W YPL168W hom Uncharacterized 0.545087149648743 0.292846790152103 no 1465 0.298159111010367 984 NA FT MITOCHONDRION Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; expression may be cell cycle-regulated biological_process molecular_function mitochondrion
YMR194C-A_d YMR194C-A YMR194C-A hom Dubious 0.54298938684153 0.293568554895045 no 1466 0.285462462403729 977 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YNR020C YNR020C ATP23 hom Verified 0.542783791999606 0.293639336983899 no 1467 0.309042029726055 1061 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Putative metalloprotease of the mitochondrial inner membrane, required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex; substrate of the Mia40p-Erv1p disulfide relay system, and folding is assisted by Mia40p protein processing|mitochondrial proton-transporting ATP synthase complex assembly metalloendopeptidase activity mitochondrial inner membrane|mitochondrial intermembrane space
YPR120C YPR120C CLB5 hom Verified 0.542744284841267 0.293652939393388 no 1468 0.311702837933845 1023 NA FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION NUCLEUS B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase spindle assembly|G1/S transition of mitotic cell cycle|regulation of S phase of mitotic cell cycle|G2/M transition of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|positive regulation of spindle pole body separation|premeiotic DNA replication|positive regulation of DNA replication cyclin-dependent protein kinase regulator activity nucleus
YBR010W YBR010W HHT1 hom Verified 0.540181944388126 0.294535781597645 no 1469 0.306967919415902 1047 NA FT CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT2); regulated by acetylation, methylation, and phosphorylation chromatin assembly or disassembly|global genome nucleotide-excision repair|rRNA transcription|sexual sporulation resulting in formation of a cellular spore|mitotic cell cycle spindle assembly checkpoint DNA binding replication fork protection complex|nucleus|nuclear nucleosome
YML047C YML047C PRM6 hom Verified 0.539490861619544 0.29477410042291 no 1470 0.285424876697331 993 NA Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; regulated by Ste12p during mating; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family biological_process molecular_function integral to membrane
YER178W YER178W PDA1 hom Verified 0.539302243282729 0.294839160606101 no 1471 0.312201370065787 1077 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose acetyl-CoA biosynthetic process from pyruvate pyruvate dehydrogenase (acetyl-transferring) activity mitochondrial nucleoid|mitochondrion|mitochondrial pyruvate dehydrogenase complex
YLR183C YLR183C TOS4 hom Verified 0.538724209885441 0.295038583063385 no 1472 0.296066580355389 1016 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION|CHROMOSOME Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; expression is periodic and peaks in G1; relative distribution to the nucleus increases upon DNA replication stress; TOS4 has a paralog, PLM2, that arose from the whole genome duplication response to DNA damage stimulus chromatin binding nuclear chromatin|Rpd3L-Expanded complex|mitochondrion|nucleus|cytoplasm
YKL003C YKL003C MRP17 hom Verified 0.538342970067148 0.295170145411602 no 1473 0.30255643369869 1045 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YIL128W YIL128W MET18 hom Verified 0.536915819478593 0.295662881574067 no 1474 0.454187297794107 1513 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|RESPONSE TO DNA DAMAGE NUCLEUS Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Cia2p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human MMS19 methionine metabolic process|nucleotide-excision repair|transcription from RNA polymerase II promoter molecular_function cytoplasm
YPR067W YPR067W ISA2 hom Verified 0.5359787393697 0.295986622107623 no 1475 0.326445243880659 1117 NA FT KETONE METABOLISM|COFACTOR METABOLISM MITOCHONDRION Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa1p and possibly Iba57p; localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations iron-sulfur cluster assembly|biotin biosynthetic process iron ion binding mitochondrion|mitochondrial intermembrane space
YGR045C_d YGR045C YGR045C hom Dubious 0.535910699630853 0.296010134674166 no 1476 0.282267466911523 964 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YNL230C YNL230C ELA1 hom Verified 0.53528517022188 0.296226339716346 no 1477 0.306125306755005 1058 NA FT PROTEOLYSIS NUCLEUS UBIQUITIN LIGASE COMPLEX Elongin A; F-box protein that forms a heterodimer with Elc1p and is required for ubiquitin-dependent degradation of the RNA Polymerase II subunit Rpo21p; subunit of the Elongin-Cullin-Socs (ECS) ligase complex protein ubiquitination involved in ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity elongin complex|Cul3-RING ubiquitin ligase complex
YBL072C YBL072C RPS8A hom Verified 0.534285591252452 0.296571979759249 no 1478 0.27743151379571 981 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S8, no bacterial homolog; RPS8A has a paralog, RPS8B, that arose from the whole genome duplication cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit|90S preribosome
YMR305C YMR305C SCW10 hom Verified 0.534126731028568 0.29662692835224 no 1479 0.299882056441121 998 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM ENDOPLASMIC RETICULUM Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p conjugation with cellular fusion glucosidase activity fungal-type cell wall|extracellular region|endoplasmic reticulum|cytoplasm
YGR189C YGR189C CRH1 hom Verified 0.534114220399735 0.296631255885592 no 1480 0.28153273556248 956 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress fungal-type cell wall organization|cell wall chitin metabolic process transferase activity, transferring glycosyl groups incipient cellular bud site|fungal-type cell wall
YKL183W YKL183W LOT5 hom Verified 0.534106468335431 0.296633937405347 no 1481 0.280412418478273 946 NA FT NUCLEUS Protein of unknown function; gene expression increases in cultures shifted to a lower temperature; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus|cytoplasm
YNR073C_p YNR073C YNR073C hom Uncharacterized 0.532074462539307 0.297337211903643 no 1482 0.334215929505853 1118 NA Putative mannitol dehydrogenase; identical in amino acid sequence to Dsf1p biological_process mannitol dehydrogenase activity cellular_component
YAL021C YAL021C CCR4 hom Verified 0.531252625732556 0.297621864713876 no 1483 0.343049567818021 1141 NA FF|FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RNA PROCESSING NUCLEUS RNA POL II, HOLOENZYME Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|DNA replication checkpoint|nuclear-transcribed mRNA poly(A) tail shortening|traversing start control point of mitotic cell cycle|replication fork protection|transcription elongation from RNA polymerase II promoter|DNA replication 3'-5'-exoribonuclease activity CCR4-NOT core complex|cytoplasmic mRNA processing body|Cdc73/Paf1 complex|cytoplasm
YGL014W YGL014W PUF4 hom Verified 0.529919846287907 0.298083752689793 no 1484 0.320970494416797 1106 NA FT PROTEIN LOCALIZATION|CHROMATIN ORGANIZATION|TRANSLATION|GENE SILENCING Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|negative regulation of translation|protein localization|negative regulation of chromatin silencing involved in replicative cell aging mRNA binding cytoplasm
YAL024C YAL024C LTE1 hom Verified 0.529843243626427 0.298110310026954 no 1485 0.337723035171845 1168 NA FF|FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|SIGNALING|CELL DIVISION Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures regulation of exit from mitosis|mitotic cell cycle spindle orientation checkpoint|vesicle-mediated transport guanyl-nucleotide exchange factor activity cellular bud
YEL064C YEL064C AVT2 hom Verified 0.529491851769372 0.298232147700025 no 1486 0.273431542641584 937 NA FT ENDOPLASMIC RETICULUM Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters transport transporter activity integral to membrane|endoplasmic reticulum
YIL127C_p YIL127C RRT14 hom Uncharacterized 0.528539305831048 0.298562536794251 no 1487 0.286674621529543 1003 NA FT NUCLEUS Putative protein of unknown function; identified in a screen for mutants with decreased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis biological_process molecular_function nucleolus
YIR017C YIR017C MET28 hom Verified 0.526628161092481 0.299225915972855 no 1488 0.324069944398818 1098 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Basic leucine zipper (bZIP) transcriptional activator in the Cbf1p-Met4p-Met28p complex, participates in the regulation of sulfur metabolism regulation of transcription from RNA polymerase II promoter|regulation of sulfur amino acid metabolic process|Unknown RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YGR217W YGR217W CCH1 hom Verified 0.526508834500628 0.299267357708409 no 1489 0.302719010503537 1034 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together calcium ion transport voltage-gated calcium channel activity|calcium channel activity integral to membrane|plasma membrane
YGL107C YGL107C RMD9 hom Verified 0.526111863836999 0.299405243059828 no 1490 0.310368978607008 1047 NA FT TRANSLATION|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes translational initiation|regulation of mRNA stability|aerobic respiration molecular_function extrinsic to mitochondrial inner membrane|mitochondrion
YJL161W_p YJL161W FMP33 hom Uncharacterized 0.525589059616354 0.299586879872646 no 1491 0.280572622853744 950 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YJL211C_d YJL211C YJL211C hom Dubious 0.524639202163361 0.299917014633787 no 1492 0.299676129153253 999 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL210W/PEX2 Unknown Unknown Unknown
YCR037C YCR037C PHO87 hom Verified 0.524321634455896 0.30002742595288 no 1493 0.305840196618262 1048 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Low-affinity inorganic phosphate (Pi) transporter; involved in activation of PHO pathway; expression is independent of Pi concentration and Pho4p activity; contains 12 membrane-spanning segments; PHO87 has a paralog, PHO90, that arose from the whole genome duplication phosphate ion transport|transmembrane transport inorganic phosphate transmembrane transporter activity integral to membrane|membrane
YOR252W YOR252W TMA16 hom Verified 0.524135074880225 0.300092297194716 no 1494 0.290906416290376 993 NA FT NUCLEUS Protein of unknown function that associates with ribosomes biological_process molecular_function ribosome|nucleus
YJL216C YJL216C IMA5 hom Verified 0.522909687168412 0.300518551509839 no 1495 0.315083701106686 1077 NA FT CARBOHYDRATE METABOLISM Alpha-glucosidase; specificity for isomaltose, maltose, and palatinose, but not alpha-methylglucoside; member of the IMA isomaltase family; not required for isomaltose utilization, but Ima5p overexpression allows the ima1 null mutant to grow on isomaltose disaccharide catabolic process oligo-1,6-glucosidase activity cellular_component
YMR141C_d YMR141C YMR141C hom Dubious 0.522653788581197 0.30060760100267 no 1496 0.30379332448821 1041 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YBR158W YBR158W AMN1 hom Verified 0.521604746398322 0.300972778952117 no 1497 0.317786777718381 1082 NA FT CELL CYCLE|CELL DIVISION NUCLEUS Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN) mitotic cell cycle checkpoint|negative regulation of exit from mitosis protein binding nucleus|cellular bud|cytoplasm
YNL274C YNL274C GOR1 hom Verified 0.521428190516042 0.301034258784492 no 1498 0.283299658253519 956 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS NUCLEUS|MITOCHONDRION Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress glyoxylate catabolic process|metabolic process oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|glyoxylate reductase activity mitochondrion|nucleus|cytoplasm
YLR268W YLR268W SEC22 hom Verified 0.521315412015223 0.301073533184768 no 1499 0.350502318810987 1171 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog retrograde vesicle-mediated transport, Golgi to ER|ER to Golgi vesicle-mediated transport|vesicle fusion with Golgi apparatus|vesicle fusion with endoplasmic reticulum|vesicle fusion SNAP receptor activity SNARE complex|integral to membrane|Golgi apparatus|endoplasmic reticulum|ER to Golgi transport vesicle membrane
YBR222C YBR222C PCS60 hom Verified 0.521173155204271 0.301123076513598 no 1500 0.271277969348727 924 NA Peroxisomal protein that binds AMP and mRNA, localizes to both the peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid, similar to E. coli long chain acyl-CoA synthetase biological_process mRNA binding|AMP binding integral to membrane|peroxisomal matrix|peroxisomal membrane|cytoplasm
YKL081W YKL081W TEF4 hom Verified 0.520729406816195 0.301277642955799 no 1501 0.310850405996517 1033 NA FT TRANSLATION MITOCHONDRION RIBOSOME Gamma subunit of translational elongation factor eEF1B, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex translational elongation translation elongation factor activity mitochondrion|ribosome|eukaryotic translation elongation factor 1 complex
YAL048C YAL048C GEM1 hom Verified 0.519778283404054 0.301609058574279 no 1502 0.281406764290762 980 NA FT SIGNALING|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION Outer mitochondrial membrane GTPase, subunit of the ERMES complex; potential regulatory subunit of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; ortholog of metazoan Miro GTPases mitochondrion inheritance|regulation of mitochondrion organization|phospholipid homeostasis GTPase activity|calcium ion binding mitochondrial outer membrane|ERMES complex|mitochondrion
YJR120W YJR120W YJR120W hom Verified 0.519316168996638 0.301770139888651 no 1503 0.299978012667872 1033 NA FT OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p cellular respiration|sterol transport|mitochondrion organization molecular_function cellular_component
YJR043C YJR043C POL32 hom Verified 0.518600056467789 0.302019834847339 no 1504 0.321023763228799 1087 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Third subunit of DNA polymerase delta, involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; interacts with Hys2p, PCNA (Pol30p), and Pol1p RNA-dependent DNA replication|lagging strand elongation|postreplication repair|base-excision repair|DNA replication, removal of RNA primer|nucleotide-excision repair|mismatch repair|double-strand break repair via break-induced replication|leading strand elongation DNA-directed DNA polymerase activity|single-stranded DNA specific 3'-5' exodeoxyribonuclease activity delta DNA polymerase complex|nucleus
YJL075C_d YJL075C APQ13 hom Dubious 0.517993119980245 0.302231534795041 no 1505 0.303883598279165 1026 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene NET1; null mutant is sensitive to sorbate Unknown Unknown Unknown
YDR230W_d YDR230W YDR230W hom Dubious 0.517360390007704 0.302452302400829 no 1506 0.280043314646576 962 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20 Unknown Unknown Unknown
YBR296C-A_p YBR296C-A YBR296C-A hom Uncharacterized 0.517358770191683 0.302452867668206 no 1507 0.314668424094429 1074 NA Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YGL144C YGL144C ROG1 hom Verified 0.515557905738817 0.303081608311885 no 1508 0.309659571519112 1030 NA FT LIPID METABOLISM Protein with putative serine active lipase domain; ROG1 has a paralog, YDL109C, that arose from the whole genome duplication cellular lipid metabolic process lipase activity cellular_component
YML013W YML013W UBX2 hom Verified 0.515381459323356 0.30314324296138 no 1509 0.363508225000445 1244 NA FF|FT PROTEOLYSIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION UBIQUITIN LIGASE COMPLEX Bridging factor involved in ER-associated protein degradation (ERAD); bridges the cytosolic Cdc48p-Npl1p-Ufd1p ATPase complex and the membrane associated Ssm4p and Hrd1p ubiquitin ligase complexes; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain; redistributes from the ER to lipid droplets during the diauxic shift and stationary phase; required for the maintenance of lipid homeostasis proteasomal ubiquitin-dependent protein catabolic process|ER-associated protein catabolic process|lipid particle organization protein binding, bridging mitochondrial outer membrane|Doa10p ubiquitin ligase complex|integral to endoplasmic reticulum membrane|lipid particle|endoplasmic reticulum
YKR035C_d YKR035C OPI8 hom Dubious 0.515246303620283 0.30319045810771 no 1510 0.336913025237722 1125 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene DID2/YKR035W-A Unknown Unknown Unknown
YDR346C YDR346C SVF1 hom Verified 0.514933983423287 0.303299576282771 no 1511 0.328357083780193 1119 NA FT RESPONSE TO OXIDATIVE STRESS NUCLEUS Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis; mutant has increased aneuploidy tolerance cellular response to oxidative stress molecular_function nucleus|cytoplasm
YOL020W YOL020W TAT2 hom Verified 0.514867044327027 0.303322965693618 no 1512 0.321224154110392 1067 NA FT PLASMA MEMBRANE High affinity tryptophan and tyrosine permease, overexpression confers FK506 and FTY720 resistance aromatic amino acid transport|tryptophan transport high-affinity tryptophan transmembrane transporter activity|aromatic amino acid transmembrane transporter activity integral to membrane|plasma membrane
YFL036W YFL036W RPO41 hom Verified 0.514839257825614 0.303332674903673 no 1513 0.308746644044826 1004 NA FT MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation transcription from mitochondrial promoter|mitochondrial genome maintenance DNA-directed RNA polymerase activity mitochondrial nucleoid|mitochondrion|mitochondrial DNA-directed RNA polymerase complex|mitochondrial matrix
YCL032W YCL032W STE50 hom Verified 0.513094320005777 0.303942672272682 no 1514 0.310923435767782 1054 NA FT CELL CYCLE|SIGNALING Protein involved in mating response, invasive/filamentous growth, and osmotolerance, acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction pheromone-dependent signal transduction involved in conjugation with cellular fusion|MAPK cascade involved in osmosensory signaling pathway|osmosensory signaling pathway via Sho1 osmosensor|signal transduction involved in filamentous growth|cellular response to heat SAM domain binding|protein kinase regulator activity cytoplasm
YOL028C YOL028C YAP7 hom Verified 0.512796463671987 0.304046851863582 no 1515 0.31023357646502 1041 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Putative basic leucine zipper (bZIP) transcription factor; YAP7 has a paralog, YAP5, that arose from the whole genome duplication positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding nucleus
YIR029W YIR029W DAL2 hom Verified 0.512522946742402 0.304142532409661 no 1516 0.292467951085885 988 NA Allantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation allantoin catabolic process allantoicase activity cellular_component
YPR109W_p YPR109W YPR109W hom Uncharacterized 0.507569580714649 0.305877614047742 no 1517 0.325031732676561 1094 NA FT CELL CYCLE Predicted membrane protein; dipoid deletion strain has high budding index biological_process molecular_function cellular_component
YGR096W YGR096W TPC1 hom Verified 0.50735262671295 0.305953709494961 no 1518 0.339906096170211 1132 NA FT MITOCHONDRION Mitochondrial membrane transporter that mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family thiamine pyrophosphate transport thiamine transmembrane transporter activity integral to membrane|integral to mitochondrial inner membrane
YKL054C YKL054C DEF1 hom Verified 0.506459726810225 0.306266977474741 no 1519 0.305793835831089 1052 NA FT RESPONSE TO DNA DAMAGE|PROTEOLYSIS NUCLEUS|CHROMOSOME RNAPII degradation factor, forms a complex with Rad26p in chromatin, enables ubiquitination and proteolysis of RNAPII present in an elongation complex; mutant is deficient in Zip1p loading onto chromosomes during meiosis transcription-coupled nucleotide-excision repair|telomere maintenance|response to DNA damage stimulus|ubiquitin-dependent protein catabolic process molecular_function nucleus
YCR009C YCR009C RVS161 hom Verified 0.506378784183184 0.306295382663493 no 1520 0.316165199283867 1044 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION|RESPONSE TO NUTRIENT LEVELS SITE OF POLARIZED GROWTH|CYTOSKELETON Amphiphysin-like lipid raft protein; interacts with Rvs167p and regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress conjugation with cellular fusion|actin cytoskeleton reorganization|endocytosis|actin cortical patch localization|response to starvation|response to osmotic stress|lipid tube assembly|actin cytoskeleton organization cytoskeletal protein binding|lipid binding membrane raft|mating projection tip|mating projection|actin cortical patch
YDR063W YDR063W AIM7 hom Verified 0.505362701937407 0.30665205531047 no 1521 0.294016149212869 1011 NA FT CYTOSKELETON ORGANIZATION NUCLEUS|CYTOSKELETON Protein that interacts with Arp2/3 complex to stimulate actin filament debranching and inhibit actin nucleation; has similarity to Cof1p and also to human glia maturation factor (GMF); null mutant displays elevated mitochondrial genome loss actin filament debranching|negative regulation of Arp2/3 complex-mediated actin nucleation molecular_function nucleus|actin cortical patch|cytoplasm
YBR041W YBR041W FAT1 hom Verified 0.504415997080047 0.306984539462304 no 1522 0.350704994043842 1154 NA FT KETONE METABOLISM|LIPID METABOLISM ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Very long chain fatty acyl-CoA synthetase and long chain fatty acid transporter; activates imported fatty acids with a preference for very long lengths (C20-C26); has a separate function in the transport of long chain fatty acids very long-chain fatty acid metabolic process|long-chain fatty acid transport very long-chain fatty acid-CoA ligase activity|long-chain fatty acid transporter activity intrinsic to internal side of plasma membrane|integral to membrane|endoplasmic reticulum|lipid particle|peroxisome
YDR198C YDR198C RKM2 hom Verified 0.50211454055035 0.307793476277669 no 1523 0.326685421854686 1103 NA Ribosomal protein lysine methyltransferase, responsible for trimethylation of the lysine residue at position 3 of Rpl12Ap and Rpl12Bp peptidyl-lysine trimethylation|peptidyl-lysine monomethylation protein-lysine N-methyltransferase activity cellular_component
YPL270W YPL270W MDL2 hom Verified 0.501864801894397 0.307881312998397 no 1524 0.313021192118805 1073 NA FT NUCLEOTIDE METABOLISM MITOCHONDRION Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, required for respiratory growth at high temperature; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis oligopeptide transport|oligopeptide export from mitochondrion oligopeptide-transporting ATPase activity mitochondrion|integral to membrane|mitochondrial inner membrane
YMR017W YMR017W SPO20 hom Verified 0.50168380220924 0.307944980103926 no 1525 0.280946754932014 971 NA FT PLASMA MEMBRANE Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog ascospore-type prospore assembly SNAP receptor activity SNARE complex|prospore membrane
YGL004C YGL004C RPN14 hom Verified 0.501512466679685 0.308005253144579 no 1526 0.326111755453317 1087 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS NUCLEUS Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p proteasome regulatory particle assembly|ubiquitin-dependent protein catabolic process molecular_function cytosol|nucleus|cytoplasm
YNL041C YNL041C COG6 hom Verified 0.5011864792165 0.308119944509884 no 1527 0.40359965228984 1327 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments intra-Golgi vesicle-mediated transport|CVT pathway molecular_function Golgi transport complex
YGL258W YGL258W VEL1 hom Verified 0.49984046608684 0.308593707325185 no 1528 0.332746366630167 1130 NA Protein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants; VEL1 has paralog YOR387C biological_process molecular_function cytosol
YJL098W YJL098W SAP185 hom Verified 0.498817102480879 0.308954119011252 no 1529 0.311329835794089 1047 NA FT CELL CYCLE|RNA PROCESSING MITOCHONDRION Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap190p; SAP185 has a paralog, SAP190, that arose from the whole genome duplication tRNA wobble uridine modification|G1/S transition of mitotic cell cycle protein serine/threonine phosphatase activity mitochondrion|cytoplasm
YDR018C_p YDR018C YDR018C hom Uncharacterized 0.49761603858398 0.309377348504763 no 1530 0.303817933179039 1055 NA FT LIPID METABOLISM Probable membrane protein with three predicted transmembrane domains; similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase; YDR018C has a paralog, CST26, that arose from the whole genome duplication phospholipid biosynthetic process transferase activity, transferring acyl groups integral to membrane
YKL098W YKL098W MTC2 hom Verified 0.49734703829102 0.309472173211288 no 1531 0.349014381289187 1171 NA Protein of unknown function; mtc2 is synthetically sick with cdc13-1 biological_process molecular_function cellular_component
YKL149C YKL149C DBR1 hom Verified 0.496177556384134 0.309884572137727 no 1532 0.293331448641513 1014 NA FT RNA PROCESSING NUCLEUS RNA lariat debranching enzyme, involved in intron turnover; required for efficient Ty1 transposition snoRNA metabolic process|pseudohyphal growth|RNA catabolic process|transposition, RNA-mediated RNA lariat debranching enzyme activity nucleus
YMR042W YMR042W ARG80 hom Verified 0.495862774812799 0.30999561568424 no 1533 0.307988234791948 1043 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Transcription factor involved in regulation of arginine-responsive genes; acts with Arg81p and Arg82p Unknown|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding nucleus
YJL115W YJL115W ASF1 hom Verified 0.494796838405641 0.310371768155469 no 1534 0.278947435483546 946 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition DNA replication-independent nucleosome assembly|histone acetylation|nucleosome disassembly|histone exchange|positive regulation of histone acetylation|chromatin silencing at silent mating-type cassette|chromatin silencing at telomere|DNA replication-dependent nucleosome assembly|regulation of transcription from RNA polymerase II promoter in response to stress histone binding chromatin assembly complex
YML122C_d YML122C YML122C hom Dubious 0.493652284610256 0.310775884415384 no 1535 0.386346156577763 1263 NA FF Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YKL002W YKL002W DID4 hom Verified 0.491040633017023 0.311698854504911 no 1536 0.316463656949341 1096 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT Class E Vps protein of the ESCRT-III complex, required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis protein retention in Golgi apparatus|intralumenal vesicle formation|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|late endosome to vacuole transport molecular_function ESCRT III complex|cytoplasm
YLR083C YLR083C EMP70 hom Verified 0.490647396291439 0.311837928944201 no 1537 0.34110649997974 1138 NA FT VESICLE-MEDIATED TRANSPORT|ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT Protein with a role in cellular adhesion, filamentous growth, and endosome-to-vacuole sorting; similar to Tmn2p and Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments cellular copper ion homeostasis|vacuolar transport|pseudohyphal growth|endosomal transport|invasive growth in response to glucose limitation molecular_function endosome|fungal-type vacuole membrane|integral to membrane
YKR060W YKR060W UTP30 hom Verified 0.490398613751244 0.311925928717467 no 1538 0.320456307846986 1088 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION NUCLEUS Putative subunit of U3-containing 90S preribosome complex; complex is involved in production of 18S rRNA and assembly of small ribosomal subunit ribosomal small subunit biogenesis molecular_function nucleolus|nucleus|90S preribosome
YBR085W YBR085W AAC3 hom Verified 0.489087769977037 0.31238977978552 no 1539 0.299926379034758 1011 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Aac1p; has roles in maintenance of viability and in respiration; AAC3 has a paralog, PET9, that arose from the whole genome duplication heme biosynthetic process|heme transport|anaerobic respiration|transmembrane transport ATP:ADP antiporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YBL063W YBL063W KIP1 hom Verified 0.488126374105445 0.312730165443627 no 1540 0.293863242139073 992 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION CYTOSKELETON Kinesin-related motor protein required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; functionally redundant with Cin8p for chromosomal but not plasmid functions mitotic anaphase B|microtubule depolymerization|spindle pole body separation|plasmid partitioning|mitotic sister chromatid segregation microtubule motor activity|structural constituent of cytoskeleton spindle microtubule|kinesin complex|spindle pole body
YOL106W_d YOL106W YOL106W hom Dubious 0.486146417197838 0.313431679381381 no 1541 0.305651070788779 1008 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YAL012W YAL012W CYS3 hom Verified 0.486083250338549 0.313454071016035 no 1542 0.331017769031995 1117 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM Cystathionine gamma-lyase, catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine; protein abundance increases in response to DNA replication stress sulfur amino acid metabolic process|cysteine biosynthetic process|cysteine biosynthetic process via cystathionine|transsulfuration|cysteine metabolic process cystathionine gamma-lyase activity cytoplasm
YPL249C-A YPL249C-A RPL36B hom Verified 0.48377832846484 0.314271598419135 no 1543 0.269489951508013 958 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L36B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36B has a paralog, RPL36A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YFL027C YFL027C GYP8 hom Verified 0.483515306839694 0.314364946993334 no 1544 0.299392536391996 1025 NA FT VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport vesicle-mediated transport Rab GTPase activator activity intracellular
YHR108W YHR108W GGA2 hom Verified 0.483387857445999 0.314410184119441 no 1545 0.309505171557844 1091 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT GOLGI APPARATUS Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|Golgi to vacuole transport|Golgi to endosome transport ubiquitin binding|phosphatidylinositol-4-phosphate binding trans-Golgi network
YJL134W YJL134W LCB3 hom Verified 0.482636097197031 0.31467707199244 no 1546 0.3051420451024 1030 NA FT LIPID METABOLISM|SIGNALING ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Long-chain base-1-phosphate phosphatase; specific for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids; LCB3 has a paralog, YSR3, that arose from the whole genome duplication calcium-mediated signaling|sphingolipid biosynthetic process sphingosine-1-phosphate phosphatase activity integral to membrane|endoplasmic reticulum
YNL122C_p YNL122C YNL122C hom Uncharacterized 0.481674435503112 0.315018619678412 no 1547 0.310666147800803 1045 NA FT TRANSLATION MITOCHONDRION Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL122C is not an essential gene biological_process molecular_function mitochondrion
YGL211W YGL211W NCS6 hom Verified 0.480632931036147 0.315388703138595 no 1548 0.316809221180435 1109 NA FT RNA PROCESSING MITOCHONDRION Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae tRNA wobble position uridine thiolation|protein urmylation|tRNA wobble uridine modification tRNA binding cytosol|mitochondrion
YDR147W YDR147W EKI1 hom Verified 0.480398010393774 0.315472204394399 no 1549 0.322444897877012 1074 NA FT LIPID METABOLISM Ethanolamine kinase; primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; exhibits some choline kinase activity, thus contributing to phosphatidylcholine synthesis via the CDP-choline pathway; EKI1 has a paralog, CKI1, that arose from the whole genome duplication phosphatidylethanolamine biosynthetic process|phosphatidylcholine biosynthetic process ethanolamine kinase activity|choline kinase activity cytoplasm
YDR085C YDR085C AFR1 hom Verified 0.480361536526924 0.315485169675896 no 1550 0.311538339173611 1062 NA FT SIGNALING Protein required for pheromone-induced projection (shmoo) formation; regulates septin architecture during mating; has an RVXF motif that mediates targeting of Glc7p to mating projections; interacts with Cdc12p; AFR1 has a paralog, YER158C, that arose from the whole genome duplication regulation of G-protein coupled receptor protein signaling pathway|pheromone-dependent signal transduction involved in conjugation with cellular fusion|cell morphogenesis involved in conjugation with cellular fusion|cell morphogenesis involved in conjugation receptor signaling protein activity mating projection base
YPL214C YPL214C THI6 hom Verified 0.480084211279248 0.315583757272315 no 1551 0.281985638054193 961 NA Bifunctional enzyme with thiamine-phosphate pyrophosphorylase and 4-methyl-5-beta-hydroxyethylthiazole kinase activities, required for thiamine biosynthesis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern thiamine biosynthetic process hydroxyethylthiazole kinase activity|thiamine-phosphate diphosphorylase activity cytosol|cytoplasm
YDR221W YDR221W GTB1 hom Verified 0.479424020243465 0.315818504354444 no 1552 0.307481680338364 1056 NA FT CARBOHYDRATE METABOLISM ENDOPLASMIC RETICULUM Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p; involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER; relocalizes from ER to cytoplasm upon DNA replication stress polysaccharide biosynthetic process|protein N-linked glycosylation alpha-glucosidase activity glucosidase II complex|endoplasmic reticulum|endoplasmic reticulum lumen
YGR263C YGR263C SAY1 hom Verified 0.478957438154175 0.315984453859489 no 1553 0.329707320348167 1105 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Sterol deacetylase; component of the sterol acetylation/deacetylation cycle along with Atf2p; integral membrane protein with active site in the ER lumen; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum response to toxin|sterol metabolic process|sterol deacetylation steryl deacetylase activity integral to membrane|endoplasmic reticulum|endoplasmic reticulum lumen
YCL051W YCL051W LRE1 hom Verified 0.478906157732596 0.316002695057572 no 1554 0.329150255329227 1103 NA FT CELL WALL ORG/BIOGENESIS Protein involved in control of cell wall structure and stress response; overproduction confers resistance to cell-wall degrading enzymes; exhibits genetic interactions with genes involved in the cell wall integrity pathway;
LRE1 has a paralog, HLR1, that arose from the whole genome duplication fungal-type cell wall organization molecular_function cellular_component
YDR079C-A YDR079C-A TFB5 hom Verified 0.478830694038353 0.316029539415118 no 1555 0.31498456519056 1087 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION NUCLEUS RNA POL II, HOLOENZYME Component of the RNA polymerase II general transcription and DNA repair factor TFIIH; involved in transcription initiation and in nucleotide-excision repair; homolog of Chlamydomonas reinhardtii REX1-S protein involved in DNA repair phosphorylation of RNA polymerase II C-terminal domain|nucleotide-excision repair|transcription from RNA polymerase II promoter core RNA polymerase binding transcription factor activity core TFIIH complex|holo TFIIH complex|nucleus
YML095C YML095C RAD10 hom Verified 0.478496332909403 0.316148491851259 no 1556 0.305674734868528 1004 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS Single-stranded DNA endonuclease (with Rad1p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein mitotic recombination|meiotic mismatch repair|DNA strand renaturation|nucleotide-excision repair, DNA incision, 5'-to lesion|removal of nonhomologous ends|double-strand break repair via single-strand annealing, removal of nonhomologous ends single-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity nucleotide-excision repair factor 1 complex|nucleus
YDR010C_d YDR010C YDR010C hom Dubious 0.478241446247637 0.316239183207328 no 1557 0.334024040101072 1123 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YNL323W YNL323W LEM3 hom Verified 0.477914589481891 0.316355498461998 no 1558 0.394108672736067 1309 NA FF|FT MEMBRANE ORGANIZATION|SIGNALING ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Membrane protein of the plasma membrane and ER, interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane phospholipid translocation|cell surface receptor signaling pathway phospholipid-translocating ATPase activity integral to membrane|endoplasmic reticulum|plasma membrane|cytoplasm
YER130C_p YER130C YER130C hom Uncharacterized 0.477849759852639 0.316378570894821 no 1559 0.367175090979798 1208 NA FT NUCLEUS Protein of unknown function; transcription is regulated by Haa1p, Sok2p and Zap1p transcriptional activators; computational analysis suggests a role as a transcription factor; C. albicans homolog (MNL1) plays a role in adaptation to stress biological_process sequence-specific DNA binding cellular_component
YGL015C_p YGL015C YGL015C hom Uncharacterized 0.477455770759972 0.316518804354799 no 1560 0.302440438108516 1012 NA Putative protein of unknown function; null mutants accumulate cargo in the Golgi biological_process molecular_function cellular_component
YGL072C_d YGL072C YGL072C hom Dubious 0.474365381729248 0.317619687485285 no 1561 0.34346606127119 1142 NA FF Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2 Unknown Unknown Unknown
YDR395W YDR395W SXM1 hom Verified 0.471606068920926 0.318603997022142 no 1562 0.317301267276893 1075 NA FT PROTEIN LOCALIZATION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS Nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucleoplasm; similar to Nmd5p, Cse1p, Lph2p, and the human cellular apoptosis susceptibility protein, CAS1 mRNA export from nucleus|nucleocytoplasmic transport protein transporter activity integral to membrane|nucleus|cytoplasm
YHR079C-A YHR079C-A SAE3 hom Verified 0.47147855316174 0.318649515818578 no 1563 0.319621011988685 1095 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Mei5p; proposed to be an assembly factor for Dmc1p double-strand break repair|reciprocal meiotic recombination|meiotic DNA recombinase assembly molecular_function condensed nuclear chromosome
YNR061C YNR061C YNR061C hom Verified 0.470202166759948 0.319105293127437 no 1564 0.305112928887529 1042 NA Protein of unknown function; relocalizes from vacuole to cytoplasm upon DNA replication stress biological_process molecular_function integral to membrane|fungal-type vacuole
YMR122C_d YMR122C YMR122C hom Dubious 0.469292401940882 0.319430322745235 no 1565 0.344696172446541 1160 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YKL061W_p YKL061W BLI1 hom Uncharacterized 0.469191030947963 0.319466547928837 no 1566 0.312127607615557 1043 NA Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome biological_process molecular_function endosome
YMR110C YMR110C HFD1 hom Verified 0.468287066435498 0.319789658114083 no 1567 0.303504660283198 1010 NA FT OXIDATION-REDUCTION PROCESS MITOCHONDRION Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder cellular aldehyde metabolic process 3-chloroallyl aldehyde dehydrogenase activity mitochondrial outer membrane|endosome|mitochondrion|lipid particle|integral to mitochondrial outer membrane
YBR270C_p YBR270C BIT2 hom Uncharacterized 0.467411802094358 0.320102640163937 no 1568 0.295218525682265 1015 NA Subunit of TORC2 membrane-associated complex; involved in regulation of actin cytoskeletal dynamics during polarized growth and cell wall integrity; interacts with Slm1p and Slm2p, homologous PH domain-containing TORC2 substrates; BIT2 has a paralog, BIT61, that arose from the whole genome duplication biological_process molecular_function cellular_component
YMR158W-B_d YMR158W-B YMR158W-B hom Dubious 0.467007345560106 0.320247311329564 no 1569 0.300819416567072 1025 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene ATG16/YMR159C Unknown Unknown Unknown
YLR047C YLR047C FRE8 hom Verified 0.466745269988341 0.320341068451117 no 1570 0.352946683657564 1188 NA FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p cellular metal ion homeostasis oxidoreductase activity, oxidizing metal ions integral to membrane|membrane
YLR425W YLR425W TUS1 hom Verified 0.466047894756384 0.320590609189934 no 1571 0.386707001606316 1264 NA FT SIGNALING|CELL WALL ORG/BIOGENESIS SITE OF POLARIZED GROWTH Guanine nucleotide exchange factor (GEF) that modulate Rho1p activity; involved in the cell integrity signaling pathway; interacts with Rgl1p; localization of Tus1p to the bed neck is regulated by Rgl1p; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate fungal-type cell wall organization|signal transduction Rho guanyl-nucleotide exchange factor activity incipient cellular bud site|cellular bud neck
YLR281C_p YLR281C YLR281C hom Uncharacterized 0.465772852306598 0.320689049529488 no 1572 0.307119460371144 1053 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION MITOCHONDRION Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR281C is not an essential gene biological_process molecular_function mitochondrion
YER049W YER049W TPA1 hom Verified 0.46570259609837 0.320714196924935 no 1573 0.308799915188983 1007 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|OXIDATION-REDUCTION PROCESS NUCLEUS Poly(rA)-binding protein involved in translation termination efficiency, mRNA poly(A) tail length and mRNA stability; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; similar to prolyl 4-hydroxylases; binds Fe(III) and 2-oxoglutarate nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|translational termination poly(A) RNA binding nucleus
YER069W YER069W ARG5,6 hom Verified 0.465313832604502 0.320853365182457 no 1574 0.311634529697114 1024 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine ornithine biosynthetic process|arginine biosynthetic process|regulation of transcription, DNA-dependent N-acetyl-gamma-glutamyl-phosphate reductase activity|acetylglutamate kinase activity mitochondrion|mitochondrial matrix
YPR158W YPR158W CUR1 hom Verified 0.465093793095522 0.320932145350292 no 1575 0.342119261999744 1158 NA FT NUCLEUS Sorting factor, central regulator of spatial protein quality control; physically and functionally interacts with chaperones to promote sorting and deposition of misfolded proteins into cytosolic compartments; involved in destabilization of [URE3] prions; CUR1 has a paralog, BTN2, that arose from the whole genome duplication cellular response to stress|protein localization to nucleus chaperone binding nucleus
YDR505C YDR505C PSP1 hom Verified 0.463843663227633 0.321379879005152 no 1576 0.312406710627073 1030 NA FT MITOCHONDRION Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication biological_process molecular_function mitochondrion|cytoplasm
YCR095W-A_p YCR095W-A YCR095W-A hom Uncharacterized 0.463123689819069 0.321637855163053 no 1577 0.318623066464523 1055 NA Putative protein of unknown function biological_process molecular_function cellular_component
YNL202W YNL202W SPS19 hom Verified 0.462991626883489 0.321685184430318 no 1578 0.340717923172171 1169 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate fatty acid catabolic process|ascospore formation 2,4-dienoyl-CoA reductase (NADPH) activity peroxisomal matrix
YCL039W YCL039W GID7 hom Verified 0.462147097323579 0.321987918866981 no 1579 0.318125971476505 1065 NA FT KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS NUCLEUS Subunit of GID Complex that binds directly to central component Vid30p; GID complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; Gid7p contains six WD40 repeats; computational analysis suggests that Gid7p and Moh1p have similar functions negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process molecular_function nucleus|GID complex|cytoplasm
YNL170W_d YNL170W YNL170W hom Dubious 0.461814835141893 0.32210705569141 no 1580 0.32253625235556 1123 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOL016C YOL016C CMK2 hom Verified 0.460722196515299 0.32249896400324 no 1581 0.332964792144687 1098 NA FT SIGNALING|PROTEIN PHOSPHORYLATION Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK2 has a paralog, CMK1, that arose from the whole genome duplication signal transduction|protein phosphorylation protein kinase activity|calmodulin-dependent protein kinase activity cytoplasm
YDL067C YDL067C COX9 hom Verified 0.459978498297795 0.322765827040672 no 1582 0.329185400163594 1080 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain mitochondrial electron transport, cytochrome c to oxygen cytochrome-c oxidase activity mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YER116C YER116C SLX8 hom Verified 0.459681999933739 0.322872245732421 no 1583 0.279587574223254 957 NA FT RESPONSE TO DNA DAMAGE NUCLEUS UBIQUITIN LIGASE COMPLEX Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex; stimulated by prior attachment of SUMO to the substrate; contains a C-terminal RING domain; forms nuclear foci upon DNA replication stress protein sumoylation|telomere maintenance|response to DNA damage stimulus|protein ubiquitination ubiquitin-protein ligase activity ubiquitin ligase complex|nucleus
YPL271W YPL271W ATP15 hom Verified 0.45885210749272 0.323170186420706 no 1584 0.353911682452658 1164 NA FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS MITOCHONDRION Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated ATP synthesis coupled proton transport hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism proton-transporting ATP synthase complex, catalytic core F(1)|mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase, central stalk
YKR058W YKR058W GLG1 hom Verified 0.458275568186872 0.323377237304129 no 1585 0.315025419031152 1095 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG1 has a paralog, GLG2, that arose from the whole genome duplication glycogen biosynthetic process glycogenin glucosyltransferase activity cellular_component
YGR212W YGR212W SLI1 hom Verified 0.457769231290223 0.323559121727769 no 1586 0.334037688752532 1131 NA FT ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin response to drug N-acetyltransferase activity nuclear envelope|plasma membrane
YBL024W YBL024W NCL1 hom Verified 0.456552194575662 0.323996473446561 no 1587 0.350023943452786 1166 NA FT RNA PROCESSING NUCLEUS S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase, methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; increases proportion of tRNALeu(CAA) with m5C at wobble position in response to hydrogen peroxide, causing selective translation of mRNA from genes enriched in TTG codon; loss of NCL1 confers hypersensitivity to oxidative stress; similar to Nop2p and human proliferation associated nucleolar protein p120 tRNA methylation tRNA (cytosine-5-)-methyltransferase activity nucleus
YJL197W YJL197W UBP12 hom Verified 0.45638193342466 0.324057677524254 no 1588 0.317411224496943 1087 NA FT PROTEOLYSIS NUCLEUS Ubiquitin-specific protease; cleaves ubiquitin from ubiquitinated proteins; present in the nucleus and cytoplasm biological_process ubiquitin-specific protease activity nucleus|cytoplasm
YDL036C YDL036C PUS9 hom Verified 0.456280756846169 0.324094049901162 no 1589 0.307942743739662 1032 NA FT RNA PROCESSING NUCLEUS|MITOCHONDRION Mitochondrial tRNA:pseudouridine synthase, catalyzes the formation of pseudouridine at position 32 in mitochondrial tRNAs; contains an N-terminal mitochondrial targeting sequence tRNA pseudouridine synthesis pseudouridine synthase activity mitochondrion|nucleus|cytoplasm
YLR385C YLR385C SWC7 hom Verified 0.455655734755959 0.324318778832604 no 1590 0.315971827433423 1082 NA FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin chromatin remodeling molecular_function Swr1 complex|nucleus
YHR094C YHR094C HXT1 hom Verified 0.454038716334756 0.324900480450837 no 1591 0.319583763918833 1087 NA FT PLASMA MEMBRANE Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting; HXT1 has a paralog, HXT6, what arose from the whole genome duplication mannose transport|glucose transport galactose transmembrane transporter activity|pentose transmembrane transporter activity|mannose transmembrane transporter activity|glucose transmembrane transporter activity|fructose transmembrane transporter activity integral to membrane|plasma membrane
YDL151C_d YDL151C BUD30 hom Dubious 0.453295655912539 0.325167930242503 no 1592 0.338922792867015 1127 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 96% of ORF overlaps the verified gene RPC53; diploid mutant displays a weak budding pattern phenotype in a systematic assay Unknown Unknown Unknown
YML050W YML050W AIM32 hom Verified 0.452217483400134 0.32555615713428 no 1593 0.34209966328021 1153 NA Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss biological_process molecular_function cellular_component
YJL160C_p YJL160C YJL160C hom Uncharacterized 0.452169786705059 0.325573336071184 no 1594 0.353872149640627 1210 NA Putative protein of unknown function; member of the PIR (proteins with internal repeats) family of cell wall proteins; non-essential gene that is required for sporulation; mRNA is weakly cell cycle regulated, peaking in mitosis; YJL160C has a paralog, PIR1, that arose from the whole genome duplication biological_process molecular_function cellular_component
YDR402C YDR402C DIT2 hom Verified 0.45104724197035 0.325977750340411 no 1595 0.342122058907352 1168 NA FT CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS N-formyltyrosine oxidase, sporulation-specific microsomal enzyme involved in the production of N,N-bisformyl dityrosine required for spore wall maturation, homologous to cytochrome P-450s ascospore wall assembly oxidoreductase activity cellular_component
YGL213C YGL213C SKI8 hom Verified 0.449522885061119 0.326527251548096 no 1596 0.316154382269976 1046 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE NUCLEUS|CHROMOSOME Ski complex component and WD-repeat protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; also required for meiotic double-strand break recombination; null mutants have superkiller phenotype nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|protein complex assembly|nuclear-transcribed mRNA catabolic process, non-stop decay|protein-DNA complex assembly|reciprocal meiotic recombination molecular_function Ski complex|nuclear chromosome
YML005W YML005W TRM12 hom Verified 0.449445323368217 0.326555221118384 no 1597 0.356121710101406 1179 NA FT RNA PROCESSING S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; required for wybutosine formation in phenylalanine-accepting tRNA wybutosine biosynthetic process|tRNA methylation S-adenosylmethionine-dependent methyltransferase activity|transferase activity, transferring alkyl or aryl (other than methyl) groups cytoplasm
YNL049C YNL049C SFB2 hom Verified 0.449099333409593 0.326680000646333 no 1598 0.314626036173241 1044 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Component of the Sec23p-Sfb2p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb3p cargo loading into COPII-coated vesicle signal sequence binding COPII vesicle coat
YPR015C_p YPR015C YPR015C hom Uncharacterized 0.447607752780564 0.32721815348386 no 1599 0.332012266027247 1108 NA Putative protein of unknown function; overexpression causes a cell cycle delay or arrest biological_process sequence-specific DNA binding cellular_component
YNR004W_p YNR004W SWM2 hom Uncharacterized 0.44720054103876 0.327365135395071 no 1600 0.316523831216617 1086 NA FT NUCLEUS Putative protein of unknown function; haploid disruptant exhibits cold-sensitive growth and elongated buds biological_process molecular_function nucleolus
YLR304C YLR304C ACO1 hom Verified 0.446802979903854 0.327508659772076 no 1601 0.386744395714034 1271 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy propionate metabolic process|glutamate biosynthetic process|tricarboxylic acid cycle|mitochondrial genome maintenance|citrate metabolic process double-stranded DNA binding|aconitate hydratase activity|single-stranded DNA binding mitochondrial nucleoid|cytosol|mitochondrion|mitochondrial matrix
YKL075C_p YKL075C YKL075C hom Uncharacterized 0.446682662851234 0.327552100709529 no 1602 0.336015148256732 1145 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; proposed to be involved in resistance to streptozotocin and camptothecin response to drug molecular_function cytoplasm
YPR044C_d YPR044C OPI11 hom Dubious 0.44598098453376 0.327805490876748 no 1603 0.328840673858994 1110 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RPL43A/YPR043W; deletion confers sensitivity to GSAO Unknown Unknown Unknown
YER156C_p YER156C YER156C hom Uncharacterized 0.44583657608372 0.32785764951911 no 1604 0.29888266044374 1014 NA FT NUCLEUS Putative protein of unknown function; interacts with Hsp82p and copurifies with Ipl1p; expression is copper responsive and downregulated in strains deleted for MAC1, a copper-responsive transcription factor; similarity to mammalian MYG1 biological_process molecular_function nucleus|cytoplasm
YPL249C YPL249C GYP5 hom Verified 0.44580315830635 0.327869720107774 no 1605 0.314732466169849 1037 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM GOLGI APPARATUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress vesicle-mediated transport|ER to Golgi vesicle-mediated transport Rab GTPase activator activity cytosol|incipient cellular bud site|plasma membrane|cellular bud neck|Golgi-associated vesicle|cellular bud tip
YPR132W YPR132W RPS23B hom Verified 0.44548374234067 0.327985103063058 no 1606 0.303517818185756 1025 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23B has a paralog, RPS23A, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|regulation of translational fidelity structural constituent of ribosome cytosolic small ribosomal subunit
YLR077W YLR077W FMP25 hom Verified 0.445163980961892 0.328100627238449 no 1607 0.335183035429411 1134 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial inner membrane protein required for an early step in assembly of respiratory complex III (cytochrome bc1 complex); mRNA is targeted to mitochondria mitochondrial respiratory chain complex III assembly molecular_function mitochondrion|integral to mitochondrial inner membrane
YBR093C YBR093C PHO5 hom Verified 0.444606821867162 0.328301958329744 no 1608 0.321371967298946 1052 NA FT RESPONSE TO NUTRIENT LEVELS Repressible acid phosphatase (1 of 3) that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2 cellular response to phosphate starvation|phosphate-containing compound metabolic process|regulation of cell size nucleoside-triphosphate diphosphatase activity|nucleoside-triphosphatase activity|acid phosphatase activity fungal-type cell wall|cell wall-bounded periplasmic space
YER090W YER090W TRP2 hom Verified 0.444455937760901 0.328356489334043 no 1609 0.471245798341115 1556 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p tryptophan biosynthetic process anthranilate synthase activity anthranilate synthase complex|cytoplasm
YOL117W YOL117W RRI2 hom Verified 0.444083817149339 0.328490993023088 no 1610 0.311045563933269 1076 NA FT SIGNALING NUCLEUS Subunit of the COP9 signalosome (CSN) complex that cleaves the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; plays a role in the mating pheromone response adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|cullin deneddylation molecular_function signalosome
YOR051C YOR051C ETT1 hom Verified 0.444056505811903 0.328500865632724 no 1611 0.308029350777321 1040 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION NUCLEUS Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts; deletion increases stop codon readthrough translational termination molecular_function nucleus
YKR018C YKR018C YKR018C hom Verified 0.443776279962664 0.328602169690219 no 1612 0.326934179180533 1094 NA FT NUCLEUS|MITOCHONDRION Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress; YKR018C has a paralog, IML2, that arose from the whole genome duplication biological_process molecular_function nucleus|cytoplasm
YHR129C YHR129C ARP1 hom Verified 0.443395880178955 0.328739707645692 no 1613 0.326166524751297 1098 NA FT CELL CYCLE|CYTOSKELETON ORGANIZATION CYTOSKELETON Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; putative ortholog of mammalian centractin nuclear migration|establishment of mitotic spindle orientation structural constituent of cytoskeleton cell cortex|dynactin complex|spindle pole body|astral microtubule
YOL159C-A YOL159C-A YOL159C-A hom Verified 0.443272092718592 0.328784469442247 no 1614 0.306427561317341 1011 NA FT NUCLEUS Protein of unknown function; overexpression affects endocytic protein trafficking; identified by sequence comparison with hemiascomycetous yeast species biological_process molecular_function nucleus|cytoplasm
YJR137C YJR137C MET5 hom Verified 0.442816655130201 0.328949177735684 no 1615 0.284496461325426 949 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine fungal-type cell wall organization|sulfate assimilation sulfite reductase (NADPH) activity sulfite reductase complex (NADPH)|cytoplasm
YGR239C YGR239C PEX21 hom Verified 0.442637492929704 0.329013980572359 no 1616 0.34682056154266 1173 NA FT PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION Peroxin required for peroxisomal matrix protein targeting; acts on proteins containing the PTS2 targeting sequence; interacts with Pex7p; partially redundant with Pex18p; relative distribution to cytoplasmic foci increases upon DNA replication stress protein import into peroxisome matrix|positive regulation of protein binding protein binding cytosol|peroxisome
YPL084W YPL084W BRO1 hom Verified 0.442420540642306 0.329092458935302 no 1617 0.33648841895088 1131 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes protein deubiquitination|vacuolar transport|protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|response to nutrient|ubiquitin-dependent protein catabolic process ubiquitin-specific protease activity endosome|cytoplasm
YJR090C YJR090C GRR1 hom Verified 0.441521815721298 0.329417635783581 no 1618 0.364083757120783 1209 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CARBOHYDRATE METABOLISM|PROTEOLYSIS NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON UBIQUITIN LIGASE COMPLEX F-box protein component of the SCF ubiquitin-ligase complex; involved in carbon catabolite repression, glucose-dependent divalent cation transport, high-affinity glucose transport, morphogenesis, and sulfite detoxification SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular response to methylmercury|cell cycle arrest in response to pheromone|G1/S transition of mitotic cell cycle|response to DNA damage stimulus|protein ubiquitination ubiquitin-protein ligase activity|protein binding, bridging cellular bud neck contractile ring|SCF ubiquitin ligase complex|nucleus|cytoplasm
YPL227C YPL227C ALG5 hom Verified 0.439544941242541 0.330133362803504 no 1619 0.335517960740652 1134 NA FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM UDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum protein N-linked glycosylation dolichyl-phosphate beta-glucosyltransferase activity endoplasmic reticulum membrane
YDL178W YDL178W DLD2 hom Verified 0.439213979658623 0.330253248243003 no 1620 0.366814439282934 1212 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION D-lactate dehydrogenase, located in the mitochondrial matrix lactate metabolic process actin binding|D-lactate dehydrogenase (cytochrome) activity mitochondrion|mitochondrial matrix
YLR300W YLR300W EXG1 hom Verified 0.438549571741471 0.330493971783301 no 1621 0.314774949220909 1045 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM Major exo-1,3-beta-glucanase of the cell wall, involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes fungal-type cell wall organization|cellular glucan metabolic process glucan exo-1,3-beta-glucosidase activity extracellular region|fungal-type cell wall
YFR018C_p YFR018C YFR018C hom Uncharacterized 0.437927655754798 0.330719363516872 no 1622 0.320728873361035 1089 NA FT PROTEOLYSIS Putative protein of unknown function biological_process molecular_function cellular_component
YOR124C YOR124C UBP2 hom Verified 0.436559207884802 0.331215525736671 no 1623 0.318370490112662 1092 NA FT PROTEOLYSIS Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; interacts with Rsp5p and is required for MVB sorting of membrane proteins; can cleave polyubiquitin and has isopeptidase activity protein deubiquitination|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ubiquitin-specific protease activity cytoplasm
YKL142W YKL142W MRP8 hom Verified 0.436425428566726 0.331264046424326 no 1624 0.321933146210338 1072 NA Protein of unknown function; undergoes sumoylation; transcription induced under cell wall stress; protein levels are reduced under anaerobic conditions; protein abundance increases in response to DNA replication stress; originally thought to be a mitochondrial ribosomal protein based on sequence analysis biological_process molecular_function cytoplasm
YGR169C YGR169C PUS6 hom Verified 0.435955739925118 0.331434421163134 no 1625 0.29075032353271 966 NA FT RNA PROCESSING MITOCHONDRION tRNA:pseudouridine synthase, catalyzes the conversion of uridine to pseudouridine at position 31 in cytoplasmic and mitochondrial tRNAs; mutation of Asp168 to Ala abolishes enzyme activity; not essential for viability tRNA pseudouridine synthesis pseudouridine synthase activity mitochondrion|cytoplasm
YBR171W YBR171W SEC66 hom Verified 0.435817879660964 0.33148443518504 no 1626 0.446747741247065 1455 NA FF|FT PROTEIN LOCALIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER posttranslational protein targeting to membrane, translocation|filamentous growth protein transporter activity integral to membrane|Sec62/Sec63 complex|endoplasmic reticulum membrane
YER067W YER067W RGI1 hom Verified 0.435315260022296 0.331666804901993 no 1627 0.306565049128001 1025 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS|PLASMA MEMBRANE Protein of unknown function; involved in energy metabolism under respiratory conditions; protein abundance is increased upon intracellular iron depletion; protein abundance increases in response to DNA replication stress energy reserve metabolic process molecular_function cell periphery|nucleus|cytoplasm
YCR027C YCR027C RHB1 hom Verified 0.435223573852343 0.331700076472152 no 1628 0.334629768997551 1134 NA FT VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM PLASMA MEMBRANE Putative Rheb-related GTPase involved in regulating canavanine resistance and arginine uptake; member of the Ras superfamily of G-proteins lysine transport|retrograde transport, endosome to Golgi|arginine transport GTPase activity extrinsic to plasma membrane
YOR113W YOR113W AZF1 hom Verified 0.434880266752236 0.331824669389088 no 1629 0.353408715196114 1192 NA FT TRANSCRIPTION FROM RNA POL II|CELL WALL ORG/BIOGENESIS NUCLEUS Zinc-finger transcription factor; in the presence of glucose, activates transcription of genes involved in growth and carbon metabolism; in nonfermentable carbon sources, activates transcription of genes involved in maintenance of cell wall integrity regulation of fungal-type cell wall organization|regulation of transcription from RNA polymerase II promoter|cellular response to carbohydrate stimulus RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YJL145W YJL145W SFH5 hom Verified 0.433247263506453 0.332417572964519 no 1630 0.311876168273145 1063 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Non-classical phosphatidylinositol transfer protein (PITP); exhibits PI- but not PC-transfer activity; localizes to the peripheral endoplasmic reticulum, cytosol and microsomes; similar to Sec14p; partially relocalizes to the plasma membrane upon DNA replication stress Golgi to plasma membrane protein transport|phosphatidylinositol metabolic process|Unknown|regulation of exocytosis|phospholipid transport phosphatidylinositol transporter activity|phosphatidylcholine transporter activity cell periphery|cytosol|plasma membrane|cortical endoplasmic reticulum
YNL190W_p YNL190W YNL190W hom Uncharacterized 0.431924124486598 0.332898280213108 no 1631 0.347053480699754 1172 NA Hydrophilin essential in dessication-rehydration process; cell wall protein; contains a putative GPI-attachment site cellular response to water deprivation molecular_function fungal-type cell wall
YKL027W YKL027W YKL027W hom Verified 0.429612979803863 0.333738596814469 no 1632 0.337249192199152 1124 NA FT MITOCHONDRION Protein of unknown function, localized to the mitochondrial outer membrane biological_process molecular_function mitochondrial outer membrane|mitochondrion
YLR413W_p YLR413W YLR413W hom Uncharacterized 0.429214127189065 0.33388370149601 no 1633 0.319676092581507 1082 NA FT PLASMA MEMBRANE Putative protein of unknown function; YLR413W is not an essential gene biological_process molecular_function integral to membrane
YBL029W_p YBL029W YBL029W hom Uncharacterized 0.428485217437155 0.334148946874799 no 1634 0.344818205146818 1163 NA FT NUCLEUS Non-essential protein of unknown function biological_process molecular_function nucleus|cytoplasm
YMR026C YMR026C PEX12 hom Verified 0.425790437286107 0.335130277823368 no 1635 0.352132291058546 1168 NA FT PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION C3HC4-type RING-finger peroxin and E3 ubiquitin ligase, required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder protein import into peroxisome matrix ubiquitin-protein ligase activity|protein binding integral to peroxisomal membrane
YGL162W YGL162W SUT1 hom Verified 0.42577488963313 0.335135942930026 no 1636 0.332007957891291 1120 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Transcription factor of the Zn2Cys6 family involved in sterol uptake; involved in induction of hypoxic gene expression; relocalizes from nucleus to cytoplasm upon DNA replication stress positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter RNA polymerase II repressing transcription factor binding nucleus
YPR111W YPR111W DBF20 hom Verified 0.424570086871684 0.335575051521706 no 1637 0.312589606565205 1050 NA FT CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION SITE OF POLARIZED GROWTH|CYTOSKELETON Ser/Thr kinase involved in late nuclear division, one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs cytokinesis after mitosis|protein phosphorylation|barrier septum assembly involved in cell cycle cytokinesis|regulation of mRNA catabolic process|exit from mitosis protein serine/threonine kinase activity spindle pole body|cellular bud neck|cytoplasm
YOR070C YOR070C GYP1 hom Verified 0.423212099244922 0.336070259964797 no 1638 0.393367470509895 1299 NA FF|FT VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM MITOCHONDRION|GOLGI APPARATUS Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion vesicle-mediated transport Rab GTPase activator activity mitochondrion|Golgi apparatus
YDL239C YDL239C ADY3 hom Verified 0.422275550479195 0.336411950978128 no 1639 0.336019493952512 1083 NA FT CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|MITOCHONDRION ORGANIZATION NUCLEUS|CYTOSKELETON Protein required for spore wall formation; thought to mediate assembly of a Don1p-containing structure at the leading edge of the prospore membrane via interaction with spindle pole body components; potentially phosphorylated by Cdc28p; ADY3 has a paralog, CNM67, that arose from the whole genome duplication mitochondrion inheritance|ascospore wall assembly|sporulation resulting in formation of a cellular spore molecular_function spindle pole body|prospore membrane
YPR074C YPR074C TKL1 hom Verified 0.421951817551702 0.336530093340742 no 1640 0.375466549184175 1252 NA FF|FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication pentose-phosphate shunt transketolase activity cytoplasm
YJR128W_d YJR128W YJR128W hom Dubious 0.420809314421099 0.336947164767478 no 1641 0.328192910630437 1100 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSF2 Unknown Unknown Unknown
YOR317W YOR317W FAA1 hom Verified 0.41867652941944 0.337726275488153 no 1642 0.338101321393452 1131 NA FT KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM MITOCHONDRION Long chain fatty acyl-CoA synthetase; activates imported fatty acids with a preference for C12:0-C16:0 chain lengths; functions in long chain fatty acid import; accounts for most acyl-CoA synthetase activity; localized to lipid particles; involved in sphingolipid-to-glycerolipid metabolism; forms ER foci upon DNA replication stress; FAA1 has a paralog, FAA4, that arose from the whole genome duplication long-chain fatty acid transport|long-chain fatty-acyl-CoA metabolic process long-chain fatty acid-CoA ligase activity mitochondrial outer membrane|mitochondrion|lipid particle|plasma membrane
YBR099C_d YBR099C YBR099C hom Dubious 0.418634017287158 0.337741812341675 no 1643 0.330902104367849 1091 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4 Unknown Unknown Unknown
YGL200C YGL200C EMP24 hom Verified 0.41413168631563 0.339388834138402 no 1644 0.349236479951404 1193 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles protein retention in ER lumen|vesicle organization|ER to Golgi vesicle-mediated transport molecular_function integral to membrane|endoplasmic reticulum|ER to Golgi transport vesicle
YDR001C YDR001C NTH1 hom Verified 0.413807554878872 0.339507525336019 no 1645 0.335118995796106 1147 NA FT CARBOHYDRATE METABOLISM Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p; NTH1 has a paralog, NTH2, that arose from the whole genome duplication trehalose catabolic process|response to stress alpha,alpha-trehalase activity cytosol|cytoplasm
YDL107W YDL107W MSS2 hom Verified 0.413789862100067 0.339514004576932 no 1646 0.347383166257525 1167 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Peripherally bound inner membrane protein of the mitochondrial matrix involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p protein insertion into mitochondrial membrane from inner side molecular_function extrinsic to mitochondrial inner membrane|mitochondrial matrix
YDL135C YDL135C RDI1 hom Verified 0.412866414629279 0.339852244433896 no 1647 0.319341645769724 1075 NA FT MEMBRANE ORGANIZATION|SIGNALING|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH Rho GDP dissociation inhibitor; involved in the localization and regulation of Cdc42p and Rho1p; protein abundance increases in response to DNA replication stress regulation of vacuole fusion, non-autophagic|actin filament organization|small GTPase mediated signal transduction Rho GDP-dissociation inhibitor activity cytosol|plasma membrane|cellular bud neck|cellular bud tip
YOR178C YOR178C GAC1 hom Verified 0.412575934958702 0.339958667854682 no 1648 0.343184042959571 1144 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock meiosis|glycogen metabolic process|negative regulation of transcription from RNA polymerase II promoter|response to heat|mitotic cell cycle spindle assembly checkpoint protein phosphatase type 1 regulator activity|structural molecule activity|heat shock protein binding protein phosphatase type 1 complex
YNL270C YNL270C ALP1 hom Verified 0.411741914190295 0.340264300005526 no 1649 0.332180979499553 1133 NA FT PLASMA MEMBRANE Arginine transporter; expression is normally very low and it is unclear what conditions would induce significant expression; ALP1 has a paralog, CAN1, that arose from the whole genome duplication basic amino acid transport basic amino acid transmembrane transporter activity integral to membrane|plasma membrane
YPL267W YPL267W ACM1 hom Verified 0.411592955963491 0.34031889773718 no 1650 0.341133594874127 1134 NA FT CELL CYCLE|CELL DIVISION NUCLEUS Pseudosubstrate inhibitor of the anaphase-promoting complex/cyclosome (APC/C), that suppresses APC/C [Cdh1]-mediated proteolysis of mitotic cyclins; associates with Cdh1p, Bmh1p and Bmh2p; cell cycle regulated protein negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle ubiquitin-protein ligase inhibitor activity nucleus|cytoplasm
YCL034W YCL034W LSB5 hom Verified 0.411442733219663 0.340373962343119 no 1651 0.35463401499359 1164 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION CYTOSKELETON Protein of unknown function; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; may mediate disassembly of the Pan1 complex from the endocytic coat endocytosis|actin filament organization|actin cortical patch localization|actin cytoskeleton organization molecular_function cell cortex|cytoplasm|actin cortical patch
YOL098C_p YOL098C YOL098C hom Uncharacterized 0.410772007451988 0.340619860432106 no 1652 0.346619100618015 1177 NA FT PROTEOLYSIS Putative metalloprotease biological_process molecular_function cytoplasm
YNR074C YNR074C AIF1 hom Verified 0.410500043815003 0.340719585677776 no 1653 0.345397314027714 1178 NA FT OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS NUCLEUS|MITOCHONDRION|PLASMA MEMBRANE Mitochondrial cell death effector that translocates to the nucleus in response to apoptotic stimuli, homolog of mammalian Apoptosis-Inducing Factor, putative reductase response to singlet oxygen|positive regulation of apoptotic process oxidoreductase activity, acting on a sulfur group of donors, NAD or NADP as acceptor mitochondrion|nucleus|plasma membrane
YLR126C YLR126C YLR126C hom Verified 0.409322239412525 0.34115159845084 no 1654 0.333214409722362 1140 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS Putative glutamine amidotransferase; has Aft1p-binding motif in the promoter; may be involved in copper and iron homeostasis; YLR126C is not an essential protein; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress cellular copper ion homeostasis|cellular iron ion homeostasis molecular_function cytoplasm
YDR055W YDR055W PST1 hom Verified 0.407847885474545 0.341692677659331 no 1655 0.335921306454871 1080 NA FT CELL WALL ORG/BIOGENESIS PLASMA MEMBRANE Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1 fungal-type cell wall organization molecular_function fungal-type cell wall|plasma membrane
YAR015W YAR015W ADE1 hom Verified 0.40784229197937 0.341694731059433 no 1656 0.338788385036156 1112 NA FT NUCLEOTIDE METABOLISM NUCLEUS N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase, required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine; protein abundance increases in response to DNA replication stress purine nucleotide biosynthetic process|'de novo' IMP biosynthetic process phosphoribosylaminoimidazolesuccinocarboxamide synthase activity nucleus|cytoplasm
YOR342C YOR342C YOR342C hom Verified 0.405839475561917 0.342430275714906 no 1657 0.34975765595305 1182 NA FT NUCLEUS Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; relocalizes from nucleus to cytoplasm upon DNA replication stress; YOR342C has a paralog, YAL037W, that arose from the whole genome duplication biological_process molecular_function nucleus|cytoplasm
YPR135W YPR135W CTF4 hom Verified 0.405771831896479 0.342455128655152 no 1658 0.412896242408581 1366 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Chromatin-associated protein, required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion DNA repair|replicative cell aging|double-strand break repair via break-induced replication|DNA replication initiation|DNA-dependent DNA replication|mitotic sister chromatid cohesion chromatin binding|DNA binding nuclear chromosome|replication fork protection complex|nuclear replication fork|nucleus
YPR065W YPR065W ROX1 hom Verified 0.405131797089304 0.342690317415366 no 1659 0.345937051508284 1129 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS|CHROMOSOME Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter in response to stress RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|DNA binding, bending|sequence-specific DNA binding|RNA polymerase II transcription factor recruiting transcription factor activity nuclear chromatin
YLR218C YLR218C COA4 hom Verified 0.404492497358026 0.342925296949773 no 1660 0.323135335648351 1075 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION NUCLEUS|MITOCHONDRION Twin Cx(9)C protein involved in cytochrome c oxidase assembly or stability; localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; interacts genetically with CYC1 and with cytochrome c oxidase assembly factors mitochondrial respiratory chain complex IV assembly|mitochondrial respiratory chain complex assembly molecular_function nucleus|mitochondrial intermembrane space|cytoplasm
YER169W YER169W RPH1 hom Verified 0.404008096507575 0.343103382681755 no 1661 0.352022462470666 1206 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS JmjC domain-containing histone demethylase; specifically demethylates H3K36 tri- and dimethyl modification states; associates with actively transcribed (RNA polymerase II) regions in vivo and specifically targets H3K36 in its trimethylation state as its substrate; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway; RPH1 has a paralog, GIS1, that arose from the whole genome duplication negative regulation of transcription from RNA polymerase II promoter|histone demethylation RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|sequence-specific DNA binding|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific) nucleus
YDR142C YDR142C PEX7 hom Verified 0.403440640210895 0.343312047350754 no 1662 0.369413512875357 1201 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PEROXISOME ORGANIZATION Peroxisomal signal receptor for the N-terminal nonapeptide signal (PTS2) of peroxisomal matrix proteins; WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodysplasia punctata (RCDP) protein import into peroxisome matrix, docking peroxisome matrix targeting signal-2 binding cytosol|peroxisome
YKL184W YKL184W SPE1 hom Verified 0.403208527917464 0.343397413307027 no 1663 0.346097558387406 1184 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation pantothenate biosynthetic process|putrescine biosynthetic process ornithine decarboxylase activity cytoplasm
YDL018C YDL018C ERP3 hom Verified 0.40266222775113 0.343598362393913 no 1664 0.353868569222603 1175 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport vesicle-mediated transport molecular_function integral to membrane
YEL017C-A YEL017C-A PMP2 hom Verified 0.40259143502348 0.343624405772698 no 1665 0.354495266508165 1200 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog, PMP1, that arose from the whole genome duplication cation transport molecular_function membrane
YMR319C YMR319C FET4 hom Verified 0.401822855333292 0.343907200250144 no 1666 0.38390136411211 1264 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Low-affinity Fe(II) transporter of the plasma membrane intracellular copper ion transport|zinc ion transport|low-affinity iron ion transport|copper ion import copper ion transmembrane transporter activity|iron ion transmembrane transporter activity integral to membrane|plasma membrane|integral to plasma membrane
YPR075C YPR075C OPY2 hom Verified 0.401805409679498 0.343913620292528 no 1667 0.331824833612231 1117 NA FT CELL CYCLE|SIGNALING PLASMA MEMBRANE Integral membrane protein that acts as a membrane anchor for Ste50p; involved in the signaling branch of the high-osmolarity glycerol (HOG) pathway and as a regulator of the filamentous growth pathway; overproduction blocks cell cycle arrest in the presence of mating pheromone; relocalizes from vacuole to plasma membrane upon DNA replication stress cell cycle arrest in response to pheromone|osmosensory signaling pathway molecular_function integral to membrane|plasma membrane|fungal-type vacuole|cytoplasm
YDL063C YDL063C SYO1 hom Verified 0.401306526683027 0.344097229468052 no 1668 0.35522965445016 1178 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS NUCLEUS Transport adaptor or symportin; facilitates synchronized nuclear coimport of the two 5S-rRNA binding proteins Rpl5p and Rpl11p; required for biogenesis of the large ribosomal subunit; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus ribosomal large subunit biogenesis molecular_function nucleus|cytoplasm
YGR203W YGR203W YCH1 hom Verified 0.401003025527705 0.344208948190257 no 1669 0.346464964551118 1142 NA FT NUCLEUS Phosphatase with sequence similarity to Cdc25p, Arr2p and Mih1p; member of the single-domain rhodanese homology superfamily; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus dephosphorylation phosphatase activity|protein tyrosine phosphatase activity|thiosulfate sulfurtransferase activity nucleus|cytoplasm
YLR441C YLR441C RPS1A hom Verified 0.400757531700209 0.344299324373242 no 1670 0.36254106774244 1213 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal protein 10 (rp10) of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1A has a paralog, RPS1B, that arose from the whole genome duplication cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit|90S preribosome
YDR525W_d YDR525W API2 hom Dubious 0.400057162974594 0.344557207213684 no 1671 0.384915670008074 1266 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 26% of ORF overlaps the dubious ORF YDR524C-A; insertion mutation in a cdc34-2 mutant background causes altered bud morphology Unknown Unknown Unknown
YIL066C YIL066C RNR3 hom Verified 0.399871735318404 0.344625495653598 no 1672 0.344645911283376 1165 NA FT OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM MITOCHONDRION Minor isoform of the large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits deoxyribonucleotide biosynthetic process ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor mitochondrion|ribonucleoside-diphosphate reductase complex|cytoplasm
YGL009C YGL009C LEU1 hom Verified 0.399302970461465 0.344834989322986 no 1673 0.344238369810476 1150 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway leucine biosynthetic process 3-isopropylmalate dehydratase activity cytosol
YDR349C YDR349C YPS7 hom Verified 0.39764995875895 0.345444114506205 no 1674 0.355566793326537 1189 NA FT CELL WALL ORG/BIOGENESIS|PROTEOLYSIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Putative GPI-anchored aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; located in the cytoplasm and endoplasmic reticulum fungal-type cell wall organization aspartic-type endopeptidase activity endoplasmic reticulum|cytoplasm
YDR326C YDR326C YSP2 hom Verified 0.396194516849652 0.345980767994067 no 1675 0.350831914849063 1208 NA FT MITOCHONDRION Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification; YSP2 has a paralog, YHR080C, that arose from the whole genome duplication apoptotic process molecular_function mitochondrion
YBR063C_p YBR063C YBR063C hom Uncharacterized 0.396093032528679 0.346018199053829 no 1676 0.335953171225876 1148 NA Putative protein of unknown function; YBR063C is not an essential gene biological_process molecular_function cellular_component
YLR219W YLR219W MSC3 hom Verified 0.395173110380261 0.346357567954613 no 1677 0.313459003203026 1071 NA FT CELL CYCLE PLASMA MEMBRANE Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; msc3 mutants are defective in directing meiotic recombination events to homologous chromatids; potential Cdc28p substrate; protein abundance increases in response to DNA replication stress reciprocal meiotic recombination molecular_function cellular_component
YDL190C YDL190C UFD2 hom Verified 0.393986056246152 0.346795666946112 no 1678 0.352814842016393 1170 NA FT PROTEOLYSIS NUCLEUS Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3 ER-associated protein catabolic process|protein ubiquitination|ubiquitin-dependent protein catabolic process|response to stress ubiquitin-ubiquitin ligase activity nucleus|cytoplasm
YMR145C YMR145C NDE1 hom Verified 0.391722590054144 0.347631598433858 no 1679 0.349658008609125 1178 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Mitochondrial external NADH dehydrogenase, a type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain glucose catabolic process to ethanol|NADH oxidation|chronological cell aging NADH dehydrogenase activity mitochondrion
YOR215C YOR215C AIM41 hom Verified 0.391379178516101 0.347758490260206 no 1680 0.345393229177469 1145 NA FT MITOCHONDRION Putative protein of unknown function; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss biological_process molecular_function mitochondrion
YNL012W YNL012W SPO1 hom Verified 0.389459254633733 0.348468223069252 no 1681 0.320285838020242 1105 NA FT CELL CYCLE|LIPID METABOLISM|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Meiosis-specific prospore protein; required for meiotic spindle pole body duplication and separation; required to produce bending force necessary for proper prospore membrane assembly during sporulation; has similarity to phospholipase B meiosis|spore membrane bending pathway phospholipase activity endoplasmic reticulum|nucleus|prospore membrane
YDL238C YDL238C GUD1 hom Verified 0.388916383837736 0.34866900094956 no 1682 0.346174947825826 1154 NA Guanine deaminase, a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine; activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures guanine metabolic process guanine deaminase activity|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides cytoplasm
YCL001W-A_p YCL001W-A YCL001W-A hom Uncharacterized 0.388670849400672 0.348759824483562 no 1683 0.362675488533949 1229 NA Putative protein of unknown function; YCL001W-A gene has similarity to DOM34 and is present in a region duplicated between chromosomes XIV and III biological_process molecular_function cellular_component
YML020W_p YML020W YML020W hom Uncharacterized 0.388569626604354 0.348797269461978 no 1684 0.347110781557513 1171 NA Putative protein of unknown function biological_process molecular_function cellular_component
YDR359C YDR359C EAF1 hom Verified 0.388035325776955 0.348994945808101 no 1685 0.384045628951076 1252 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS HISTONE ACETYLTRANSFERASE Component of the NuA4 histone acetyltransferase complex; acts as a platform for assembly of NuA4 subunits into the native complex; required for initiation of pre-meiotic DNA replication, likely due to its requirement for expression of IME1 DNA repair|cellular protein complex assembly|chromatin modification molecular_function histone acetyltransferase complex|NuA4 histone acetyltransferase complex
YHL045W_d YHL045W YHL045W hom Dubious 0.3877474093806 0.349101483810859 no 1686 0.344323585134581 1183 NA Putative protein of unknown function; not an essential gene Unknown Unknown Unknown
YHR096C YHR096C HXT5 hom Verified 0.387430659603626 0.349218704799902 no 1687 0.368221605536717 1211 NA FT PLASMA MEMBRANE Hexose transporter with moderate affinity for glucose; induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs; HXT5 has a paralog, HXT3, that arose from the whole genome duplication glucose transport|hexose transport mannose transmembrane transporter activity|fructose transmembrane transporter activity|glucose transmembrane transporter activity integral to membrane|plasma membrane
YPL213W YPL213W LEA1 hom Verified 0.387051166140222 0.349359164564086 no 1688 0.351936210239834 1215 NA FT RNA PROCESSING NUCLEUS Component of U2 snRNP; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; putative homolog of human U2A' snRNP protein mRNA splicing, via spliceosome molecular_function U2 snRNP|U2-type prespliceosome|cytoplasm
YLR055C YLR055C SPT8 hom Verified 0.386840003663568 0.349437329870027 no 1689 0.358277445128793 1211 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS HISTONE ACETYLTRANSFERASE Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters histone acetylation|negative regulation of transcription from RNA polymerase II promoter|chromatin modification|positive regulation of transcription from RNA polymerase II promoter TBP-class protein binding|transcription cofactor activity nucleus|SAGA complex
YMR204C YMR204C INP1 hom Verified 0.386192123949102 0.349677193168514 no 1690 0.336011143636738 1106 NA FT PEROXISOME ORGANIZATION Peripheral membrane protein of peroxisomes involved in peroxisomal inheritance; recruitment to peroxisomes is mediated by interaction with Pex3p at the peroxisomal membrane peroxisome inheritance molecular_function peroxisome|extrinsic to intraperoxisomal membrane
YLR170C YLR170C APS1 hom Verified 0.385548267582031 0.349915626375571 no 1691 0.365412773307798 1216 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex Golgi to vacuole transport|vesicle-mediated transport clathrin binding AP-1 adaptor complex
YOR219C YOR219C STE13 hom Verified 0.382705904077282 0.350968918164073 no 1692 0.363259714321918 1216 NA FT PROTEOLYSIS GOLGI APPARATUS Dipeptidyl aminopeptidase, Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences, required for maturation of alpha factor, transcription is induced by a-factor peptide pheromone maturation aminopeptidase activity trans-Golgi network
YDR223W YDR223W CRF1 hom Verified 0.381987037004367 0.351235489930442 no 1693 0.350771053717858 1148 NA FT TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS NUCLEUS|CHROMOSOME Transcriptional corepressor involved in repression of ribosomal protein (RP) gene transcription via the TOR signaling pathway which promotes accumulation of Crf1p in the nucleus; role in repression of RP genes varies by strain negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter transcription corepressor activity nuclear chromatin|nucleus|cytoplasm
YNL160W YNL160W YGP1 hom Verified 0.380007698132987 0.351969850388094 no 1694 0.354367637682633 1171 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|CELL WALL ORG/BIOGENESIS Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p cell wall assembly molecular_function extracellular region
YOL079W_d YOL079W YOL079W hom Dubious 0.379464879591495 0.352171339776722 no 1695 0.371864644706372 1225 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YKL043W YKL043W PHD1 hom Verified 0.378895312895398 0.352382802465809 no 1696 0.32829866955446 1074 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Transcriptional activator that enhances pseudohyphal growth; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate; PHD1 has a paralog, SOK2, that arose from the whole genome duplication pseudohyphal growth|positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nucleus
YJL199C_d YJL199C MBB1 hom Dubious 0.378782836371461 0.352424566956264 no 1697 0.351868354070903 1159 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; protein detected in large-scale protein-protein interaction studies Unknown Unknown Unknown
YKL162C-A_d YKL162C-A YKL162C-A hom Dubious 0.377758903311271 0.352804852893599 no 1698 0.3470774162603 1156 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YJL166W YJL166W QCR8 hom Verified 0.377330282962602 0.352964085021155 no 1699 0.343176373061131 1115 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration ubiquinol-cytochrome-c reductase activity mitochondrion|integral to membrane|mitochondrial respiratory chain complex III
YPR021C YPR021C AGC1 hom Verified 0.376038574570852 0.353444109348021 no 1700 0.361380672797946 1240 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Mitochondrial amino acid transporter, acts both as a glutamate uniporter and as an aspartate-glutamate exchanger; involved in nitrogen metabolism and nitrogen compound biosynthesis L-glutamate transport|aspartate transport|cellular nitrogen compound biosynthetic process antiporter activity|L-aspartate transmembrane transporter activity|L-glutamate transmembrane transporter activity|uniporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YER056C-A YER056C-A RPL34A hom Verified 0.375330165172628 0.353707467328352 no 1701 0.312410587291607 1067 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L34A; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34A has a paralog, RPL34B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YOR161C YOR161C PNS1 hom Verified 0.37444651281514 0.35403607170678 no 1702 0.356035577551612 1215 NA FT PLASMA MEMBRANE Protein of unknown function; has similarity to Torpedo californica tCTL1p, which is postulated to be a choline transporter, neither null mutation nor overexpression affects choline transport biological_process choline transmembrane transporter activity|molecular_function integral to membrane|plasma membrane|integral to plasma membrane
YCL030C YCL030C HIS4 hom Verified 0.373989566533321 0.354206039289236 no 1703 0.361665148828318 1199 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase, phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis histidine biosynthetic process phosphoribosyl-ATP diphosphatase activity|phosphoribosyl-AMP cyclohydrolase activity|histidinol dehydrogenase activity intracellular
YNL139C YNL139C THO2 hom Verified 0.371293283700851 0.355209549922948 no 1704 0.390346345401291 1268 NA FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION NUCLEUS Subunit of the THO complex, which is required for efficient transcription elongation and involved in transcriptional elongation-associated recombination; required for LacZ RNA expression from certain plasmids mRNA 3'-end processing|mRNA export from nucleus|transcription-coupled nucleotide-excision repair|DNA recombination|transcription elongation from RNA polymerase II promoter DNA binding|nucleic acid binding THO complex part of transcription export complex|nucleus|nucleoplasmic THO complex
YGL126W YGL126W SCS3 hom Verified 0.371090082529529 0.355285218752483 no 1705 0.361779159010221 1199 NA FT LIPID METABOLISM ENDOPLASMIC RETICULUM Protein required for inositol prototrophy; required for normal ER membrane biosynthesis; ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; disputed role in the synthesis of inositol phospholipids from inositol phospholipid metabolic process molecular_function integral to membrane|endoplasmic reticulum
YML034W YML034W SRC1 hom Verified 0.371028641213428 0.355308099628453 no 1706 0.380222992653207 1276 NA FF|FT CELL CYCLE|CHROMOSOME SEGREGATION ENDOMEMBRANE SYSTEM|NUCLEUS Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance maintenance of rDNA|mitotic sister chromatid segregation molecular_function nuclear envelope
YLR203C YLR203C MSS51 hom Verified 0.370915358808642 0.3553502876028 no 1707 0.343863974245938 1119 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Specific translational activator for the mitochondrial COX1 mRNA; loosely associated with the matrix face of the mitochondrial inner membrane; influences both COX1 mRNA translation and Cox1p assembly into cytochrome c oxidase; binds to heme B, which may be a mechanism for sensing oxygen levels in order to regulate cytochrome c oxidase biogenesis mitochondrial respiratory chain complex IV biogenesis|positive regulation of mitochondrial translation translation regulator activity extrinsic to mitochondrial inner membrane|mitochondrion
YDR524C YDR524C AGE1 hom Verified 0.369886778186632 0.355733426679175 no 1708 0.293278933293813 994 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM GOLGI APPARATUS ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport phospholipid binding|ARF GTPase activator activity endosome|trans-Golgi network|cytoplasm
YPL049C YPL049C DIG1 hom Verified 0.36870061131875 0.356175446518924 no 1709 0.380974397585126 1279 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p negative regulation of transcription from RNA polymerase II promoter by pheromones|Unknown DNA binding|transcription factor binding nucleus
YJL142C_d YJL142C IRC9 hom Dubious 0.367727098993249 0.356538366073457 no 1710 0.335132646028588 1152 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene YJL141C; null mutant displays increased levels of spontaneous Rad52p foci Unknown Unknown Unknown
YBL021C YBL021C HAP3 hom Verified 0.367401109487762 0.356659922061878 no 1711 0.366209552308867 1223 NA FT TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding carbon catabolite activation of transcription from RNA polymerase II promoter|regulation of cellular respiration RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription CCAAT-binding factor complex
YHR021W-A_p YHR021W-A ECM12 hom Uncharacterized 0.367327698351541 0.35668729784535 no 1712 0.351879124196725 1175 NA FT CELL WALL ORG/BIOGENESIS Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity fungal-type cell wall organization molecular_function cellular_component
YOR067C YOR067C ALG8 hom Verified 0.364120326665438 0.357884079358483 no 1713 0.381972434621459 1290 NA FF|FT LIPID METABOLISM|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Glucosyl transferase, involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p oligosaccharide-lipid intermediate biosynthetic process|protein N-linked glycosylation dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity integral to membrane|endoplasmic reticulum membrane
YMR089C YMR089C YTA12 hom Verified 0.363426918367672 0.358142998242922 no 1714 0.313497555388661 1052 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Component, with Afg3p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes proteolysis|signal peptide processing|protein complex assembly|protein import into mitochondrial intermembrane space metallopeptidase activity|protein binding|ATPase activity|ATP binding mitochondrion|mitochondrial inner boundary membrane|mitochondrial inner membrane|m-AAA complex|cytoplasm
YPR146C_d YPR146C YPR146C hom Dubious 0.362900803026733 0.35833949342847 no 1715 0.34009563440306 1152 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YHR121W YHR121W LSM12 hom Verified 0.362669110975166 0.358426038395449 no 1716 0.356352162329089 1184 NA FT NUCLEUS Protein of unknown function that may function in RNA processing; interacts with Pbp1p and Pbp4p and associates with ribosomes; contains an RNA-binding LSM domain and an AD domain; GFP-fusion protein is induced by the DNA-damaging agent MMS; relative distribution to the nucleus increases upon DNA replication stress RNA metabolic process RNA binding ribosome|nucleus|cytoplasmic stress granule|cytoplasm
YPR170C_d YPR170C YPR170C hom Dubious 0.362370978800827 0.358537411737371 no 1717 0.412212746503046 1329 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORFs YPR169W-A and YPR170W-B Unknown Unknown Unknown
YDR471W YDR471W RPL27B hom Verified 0.362265427654873 0.358576845400963 no 1718 0.354796111869037 1173 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L27B; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27B has a paralog, RPL27A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YLR404W YLR404W FLD1 hom Verified 0.361950505020078 0.358694508727136 no 1719 0.359797829683839 1187 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Seipin protein involved in lipid droplet morphology, number, and size; proposed to be involved in lipid metabolism; related to the human BSCL2 which is associated with lipodystrophy lipid particle organization molecular_function integral to membrane|endoplasmic reticulum|cortical endoplasmic reticulum
YDR509W_d YDR509W YDR509W hom Dubious 0.361936910202665 0.358699588408269 no 1720 0.34613477164267 1185 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPR147C_p YPR147C YPR147C hom Uncharacterized 0.361067348073987 0.359024550758216 no 1721 0.361804432600262 1216 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS biological_process molecular_function cytoplasm
YOR288C YOR288C MPD1 hom Verified 0.360208648461756 0.359345553839877 no 1722 0.349963690557832 1170 NA FT ENDOPLASMIC RETICULUM Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation protein folding protein disulfide oxidoreductase activity|protein disulfide isomerase activity fungal-type vacuole
YGR068C YGR068C ART5 hom Verified 0.359452272517144 0.359628388079324 no 1723 0.364277531596025 1192 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION Protein proposed to regulate the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membrane ubiquitin-dependent endocytosis ubiquitin protein ligase binding cellular_component
YOR234C YOR234C RPL33B hom Verified 0.359142152279858 0.359744374637243 no 1724 0.34803749068064 1169 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L33B; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33B has a paralog, RPL33A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YNL321W YNL321W VNX1 hom Verified 0.358151672177215 0.360114905745861 no 1725 0.367151716265468 1196 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Calcium/H+ antiporter localized to the endoplasmic reticulum membrane; member of the calcium exchanger (CAX) family; potential Cdc28p substrate potassium ion transport|sodium ion transport|hydrogen transport potassium:hydrogen antiporter activity|sodium:hydrogen antiporter activity|calcium:hydrogen antiporter activity fungal-type vacuole membrane|integral to membrane|endoplasmic reticulum membrane|fungal-type vacuole
YDL052C YDL052C SLC1 hom Verified 0.357965823799859 0.360184444874615 no 1726 0.382860710146533 1272 NA FT LIPID METABOLISM 1-acyl-sn-glycerol-3-phosphate acyltransferase, catalyzes the acylation of lysophosphatidic acid to form phosphatidic acid, a key intermediate in lipid metabolism; enzymatic activity detected in lipid particles and microsomes glycerophospholipid biosynthetic process 1-acylglycerol-3-phosphate O-acyltransferase activity lipid particle
YOR104W YOR104W PIN2 hom Verified 0.357306553655343 0.360431162141063 no 1727 0.368441731438485 1231 NA Protein that induces appearance of [PIN+] prion when overproduced; predicted to be palmitoylated biological_process molecular_function cellular_component
YDR352W YDR352W YPQ2 hom Verified 0.357145975005264 0.360491263954701 no 1728 0.345431308895171 1145 NA Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; mutant phenotype is functionally complemented by rat PQLC2 vacuolar transporter biological_process molecular_function fungal-type vacuole membrane|integral to membrane
YJR125C YJR125C ENT3 hom Verified 0.35709372074598 0.360510822564311 no 1729 0.35419825739796 1168 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS|CYTOSKELETON Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p late endosome to vacuole transport via multivesicular body sorting pathway|early endosome to Golgi transport|actin filament organization|endocytosis|actin cortical patch assembly|Golgi to endosome transport protein binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding clathrin vesicle coat|actin cortical patch
YNL130C-A_p YNL130C-A DGR1 hom Uncharacterized 0.356642647243253 0.36067967316637 no 1730 0.349552740133441 1171 NA FT MITOCHONDRION Protein of unknown function; dgr1 null mutant is resistant to 2-deoxy-D-glucose biological_process molecular_function cellular_component
YJL070C_p YJL070C YJL070C hom Uncharacterized 0.355526379618072 0.361097642996338 no 1731 0.317944872403765 1051 NA FT NUCLEOTIDE METABOLISM MITOCHONDRION Putative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic defect of quadruple aah1 ade8 amd1 his1 mutant; may regulate purine nucleotide homeostasis as overexpression in an AMD1 strain grown in adenine results in greatly reduced GDP and GTP intracellular levels; not an essential gene; YJL070C has a paralog, YBR284W, that arose from the whole genome duplication biological_process AMP deaminase activity|molecular_function mitochondrion|cytoplasm
YJL198W YJL198W PHO90 hom Verified 0.354530497991355 0.361470676126438 no 1732 0.360573974630367 1194 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth; PHO90 has a paralog, PHO87, that arose from the whole genome duplication phosphate ion transport phosphate ion transmembrane transporter activity integral to membrane|membrane
YGR031W YGR031W IMO32 hom Verified 0.35450091264427 0.36148176009712 no 1733 0.363027788034601 1213 NA FT MITOCHONDRION Conserved mitochondrial protein of unknown function; processed by both mitochondrial processing peptidase and mitochondrial octapeptidyl aminopeptidase; gene contains the nested antisense gene NAG1 biological_process molecular_function mitochondrion
YLR252W_d YLR252W YLR252W hom Dubious 0.354490375446707 0.361485707822295 no 1734 0.373873663752568 1247 NA Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SYM1, a mitochondrial protein involved in ethanol metabolism Unknown Unknown Unknown
YML012W YML012W ERV25 hom Verified 0.354232904807456 0.361582172901531 no 1735 0.342583054116365 1180 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Protein that forms a heterotrimeric complex with Erp1, Erp2p, and Emp24, member of the p24 family involved in endoplasmic reticulum to Golgi transport ER to Golgi vesicle-mediated transport molecular_function ER to Golgi transport vesicle
YGR214W YGR214W RPS0A hom Verified 0.352554293094809 0.362211304350296 no 1736 0.364338676118489 1194 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION RIBOSOME Ribosomal 40S subunit protein S0A; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2; RPS0A has a paralog, RPS0B, that arose from the whole genome duplication; cytoplasmic translation|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA export from nucleus|ribosomal small subunit assembly|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit|90S preribosome
YDL133W YDL133W SRF1 hom Verified 0.352315708366886 0.362300754434422 no 1737 0.417333704164241 1371 NA Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients positive regulation of catalytic activity molecular_function integral to membrane
YNL213C YNL213C RRG9 hom Verified 0.352253332503241 0.362324141606611 no 1738 0.36776275070542 1225 NA FT MITOCHONDRION ORGANIZATION MITOCHONDRION Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies mitochondrion organization|mitochondrial genome maintenance molecular_function mitochondrion
YBR297W YBR297W MAL33 hom Verified 0.351582711079751 0.362575616481526 no 1739 0.363896217005985 1203 NA FT TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM NUCLEUS MAL-activator protein, part of complex locus MAL3; nonfunctional in genomic reference strain S288C cellular carbohydrate metabolic process|regulation of transcription, DNA-dependent sequence-specific DNA binding transcription factor activity nucleus
YMR173W YMR173W DDR48 hom Verified 0.351271514832181 0.362692331437636 no 1740 0.350949686149471 1180 NA FT RESPONSE TO DNA DAMAGE DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress DNA repair ATPase activity|GTPase activity cytoplasm
YPL221W YPL221W FLC1 hom Verified 0.350130526231728 0.363120371234804 no 1741 0.359199867084974 1183 NA FT CELL WALL ORG/BIOGENESIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance protein folding|fungal-type cell wall biogenesis|FAD transport FAD transmembrane transporter activity integral to membrane|endoplasmic reticulum|fungal-type vacuole|cellular bud neck
YBL062W_d YBL062W YBL062W hom Dubious 0.349957796990735 0.363185185213174 no 1742 0.390326811247009 1305 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YBL088C YBL088C TEL1 hom Verified 0.349915720754457 0.363200974264116 no 1743 0.361190386859235 1217 NA FT CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION NUCLEUS|MITOCHONDRION|CHROMOSOME Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; regulates P-body formation induced by replication stress; homolog of human ataxia-telangiectasia mutated (ATM) gene, the gene responsible for ataxia telangiectasia (AT) (OMIM 607585) double-strand break repair|histone phosphorylation|telomere maintenance|response to DNA damage stimulus|phosphorylation|DNA damage induced protein phosphorylation protein kinase activity|telomeric DNA binding mitochondrion|nucleus
YBR182C YBR182C SMP1 hom Verified 0.349680608126862 0.363289204238645 no 1744 0.348161782264651 1162 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Putative transcription factor of the MADS-box family; involved in regulating the response to osmotic stress; SMP1 has a paralog, RLM1, that arose from the whole genome duplication positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress DNA binding, bending|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nucleus|cytoplasm
YER188W_d YER188W YER188W hom Dubious 0.34822852676103 0.363834282822842 no 1745 0.419501545480757 1376 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; large-scale analyses show mRNA expression increases under anaerobic conditions and two-hybrid interactions with Sst2p Unknown Unknown Unknown
YGR139W_d YGR139W YGR139W hom Dubious 0.348170689038474 0.363855999514928 no 1746 0.343644520615233 1131 NA Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR367W YLR367W RPS22B hom Verified 0.347942754277268 0.363941587865043 no 1747 0.355426817093349 1191 NA FT TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic small ribosomal subunit
YHR081W YHR081W LRP1 hom Verified 0.345671474525939 0.364794812115489 no 1748 0.3176247236231 1050 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|RNA LOCALIZATION NUCLEUS Nuclear exosome-associated nucleic acid binding protein; involved in RNA processing, surveillance, degradation, tethering, and export; homolog of mammalian nuclear matrix protein C1D involved in regulation of DNA repair and recombination U5 snRNA 3'-end processing|nuclear mRNA surveillance|nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|nuclear retention of pre-mRNA at the site of transcription|U4 snRNA 3'-end processing|polyadenylation-dependent snoRNA 3'-end processing|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) double-stranded RNA binding|double-stranded DNA binding nuclear exosome (RNase complex)
YPL019C YPL019C VTC3 hom Verified 0.343795071965668 0.365500203295078 no 1749 0.347282803989855 1169 NA FT MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT ENDOPLASMIC RETICULUM Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion polyphosphate metabolic process|vacuolar transport|microautophagy|vacuole fusion, non-autophagic molecular_function fungal-type vacuole membrane|integral to membrane|vacuolar transporter chaperone complex|endoplasmic reticulum
YDR025W YDR025W RPS11A hom Verified 0.343585137104735 0.365579151919549 no 1750 0.372382407590836 1237 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11A has a paralog, RPS11B, that arose from the whole genome duplication cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal small subunit assembly structural constituent of ribosome cytosolic small ribosomal subunit|90S preribosome
YKL167C YKL167C MRP49 hom Verified 0.343365020031263 0.365661935807887 no 1751 0.361415639218202 1190 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YGR036C YGR036C CAX4 hom Verified 0.341151393423461 0.36649480649708 no 1752 0.382987292557801 1248 NA FT LIPID METABOLISM|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation lipid biosynthetic process|protein N-linked glycosylation dolichyldiphosphatase activity integral to endoplasmic reticulum membrane|integral to membrane
YJR122W YJR122W IBA57 hom Verified 0.340982369786477 0.366558427059452 no 1753 0.392553904565684 1301 NA FF|FT COFACTOR METABOLISM MITOCHONDRION Mitochondrial matrix protein involved in the incorporation of iron-sulfur clusters into mitochondrial aconitase-type proteins; activates the radical-SAM family members Bio2p and Lip5p; interacts with Ccr4p in the two-hybrid system iron-sulfur cluster assembly molecular_function mitochondrion|mitochondrial matrix
YHR097C_p YHR097C YHR097C hom Uncharacterized 0.340031942721646 0.366916236407537 no 1754 0.35997219843671 1196 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus biological_process molecular_function nucleus|cytoplasm
YMR077C YMR077C VPS20 hom Verified 0.339102521344295 0.36726624954873 no 1755 0.391546365515527 1303 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT Myristoylated subunit of ESCRTIII, the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranes intralumenal vesicle formation|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|late endosome to vacuole transport protein binding ESCRT III complex|cytoplasm
YDR096W YDR096W GIS1 hom Verified 0.338138682806089 0.367629340466668 no 1756 0.363143582819508 1209 NA FT TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS NUCLEUS|MITOCHONDRION Histone demethylase and transcription factor; regulates genes during nutrient limitation; negatively regulates DPP1, PHR1; activity modulated by limited proteasome-mediated proteolysis; has JmjC and JmjN domain in N-terminal region that interact, promoting stability and proper transcriptional activity; contains two transactivating domains downstream of Jmj domains and a C-terminal DNA binding domain; GIS1 has a paralog, RPH1, that arose from the whole genome duplication negative regulation of transcription from RNA polymerase II promoter|chronological cell aging|regulation of phospholipid biosynthetic process|histone demethylation|positive regulation of transcription from RNA polymerase II promoter|maintenance of stationary phase in response to starvation RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|histone demethylase activity (H3-K36 specific) mitochondrion|nucleus
YDL130W-A YDL130W-A STF1 hom Verified 0.337934678549195 0.367706206795745 no 1757 0.379849652365217 1277 NA FT NUCLEOTIDE METABOLISM MITOCHONDRION Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p act as stabilizing factors that enhance inhibitory action of the Inh1p protein; protein abundance increases in response to DNA replication stress negative regulation of ATPase activity molecular_function mitochondrion|mitochondrial proton-transporting ATP synthase complex
YKL137W YKL137W CMC1 hom Verified 0.337826863215947 0.367746832445926 no 1758 0.368063134794684 1237 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Evolutionarily conserved copper-binding protein of the mitochondrial intermembrane space, may be involved in delivering copper from the matrix to the cytochrome c oxidase complex; contains a twin CX9C motif mitochondrial respiratory chain complex IV assembly copper ion binding extrinsic to mitochondrial inner membrane|mitochondrial intermembrane space
YKL130C YKL130C SHE2 hom Verified 0.337800344023203 0.367756825309312 no 1759 0.346230773331014 1138 NA FT RNA LOCALIZATION NUCLEUS|SITE OF POLARIZED GROWTH RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud mating type switching|intracellular mRNA localization mRNA binding cellular bud tip|cytoplasm
YGR288W YGR288W MAL13 hom Verified 0.337526111643799 0.367860165780586 no 1760 0.37289210217183 1221 NA FT TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM NUCLEUS MAL-activator protein, part of complex locus MAL1; nonfunctional in genomic reference strain S288C cellular carbohydrate metabolic process|regulation of transcription, DNA-dependent sequence-specific DNA binding transcription factor activity nucleus
YML024W YML024W RPS17A hom Verified 0.335557728455072 0.368602202597221 no 1761 0.351979822411387 1194 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17A has a paralog, RPS17B, that arose from the whole genome duplication cytoplasmic translation|ribosomal small subunit assembly structural constituent of ribosome cytosolic small ribosomal subunit
YDR057W YDR057W YOS9 hom Verified 0.334549175945213 0.368982594652235 no 1762 0.366498850846498 1222 NA FT PROTEOLYSIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM UBIQUITIN LIGASE COMPLEX ER quality-control lectin; integral subunit of the HRD ligase; binds to glycans with terminal alpha-1,6 linked mannose on misfolded N-glycosylated proteins and participates in targeting proteins to ERAD; member of the OS-9 protein family ER-associated protein catabolic process oligosaccharide binding luminal surveillance complex|Hrd1p ubiquitin ligase ERAD-L complex|endoplasmic reticulum lumen
YPL219W YPL219W PCL8 hom Verified 0.334333360012433 0.369064009842284 no 1763 0.380243676151334 1267 NA FT CELL CYCLE|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylation negative regulation of glycogen biosynthetic process cyclin-dependent protein kinase regulator activity cyclin-dependent protein kinase holoenzyme complex
YOR318C_d YOR318C YOR318C hom Dubious 0.333513150862438 0.369373482096299 no 1764 0.368708708207833 1240 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo Unknown Unknown Unknown
YDR169C-A_p YDR169C-A YDR169C-A hom Uncharacterized 0.331984067034773 0.36995064502074 no 1765 0.387573365858649 1275 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YDL039C YDL039C PRM7 hom Verified 0.331496685813355 0.370134671973944 no 1766 0.368554290155134 1189 NA Pheromone-regulated protein, predicted to have one transmembrane segment; promoter contains Gcn4p binding elements conjugation with cellular fusion molecular_function integral to membrane
YIL086C_d YIL086C YIL086C hom Dubious 0.330819427163056 0.370390442810573 no 1767 0.362622330169272 1187 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGR290W_d YGR290W YGR290W hom Dubious 0.328511991622857 0.371262289470872 no 1768 0.384661234986183 1256 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; putative HLH protein; partially overlaps the verified ORF MAL11/YGR289C (a high-affinity maltose transporter) Unknown Unknown Unknown
YHR171W YHR171W ATG7 hom Verified 0.327964446119215 0.37146927251167 no 1769 0.411305223971 1346 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS MITOCHONDRION Autophagy-related protein and dual specificity member of the E1 family of ubiquitin-activating enzymes; mediates the conjugation of Atg12p with Atg5p and Atg8p with phosphatidylethanolamine, required steps in autophagosome formation C-terminal protein lipidation|protein modification by small protein conjugation|piecemeal microautophagy of nucleus|mitochondrion degradation|macroautophagy|CVT pathway APG8 activating enzyme activity|APG12 activating enzyme activity cytosol|mitochondrion|membrane|pre-autophagosomal structure
YIL103W YIL103W DPH1 hom Verified 0.327959468699372 0.371471154245491 no 1770 0.359174071248659 1201 NA Protein required, along with Dph2p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph2p and Kti11p peptidyl-diphthamide biosynthetic process from peptidyl-histidine molecular_function cytoplasm
YMR081C YMR081C ISF1 hom Verified 0.327444530233319 0.371665845416915 no 1771 0.363477334679377 1213 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant aerobic respiration molecular_function cellular_component
YMR052W YMR052W FAR3 hom Verified 0.326818119101199 0.371902727130206 no 1772 0.384056985179713 1290 NA FT CELL CYCLE|SIGNALING ENDOPLASMIC RETICULUM Protein of unknown function; involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress re-entry into mitotic cell cycle after pheromone arrest molecular_function endoplasmic reticulum
YBR078W YBR078W ECM33 hom Verified 0.326398489443648 0.372061440127484 no 1773 0.439578896480162 1447 NA FF|FT CELL WALL ORG/BIOGENESIS MITOCHONDRION|PLASMA MEMBRANE GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p and Pst1p fungal-type cell wall organization molecular_function mitochondrion|fungal-type cell wall|plasma membrane
YBR180W YBR180W DTR1 hom Verified 0.32547731261443 0.372409925303353 no 1774 0.370318831093225 1214 NA FT CELL WALL ORG/BIOGENESIS Putative dityrosine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for spore wall synthesis; expressed during sporulation ascospore wall assembly|amine transport|transmembrane transport amine transmembrane transporter activity integral to membrane|prospore membrane
YER068C-A_d YER068C-A YER068C-A hom Dubious 0.324454242328602 0.372797079679677 no 1775 0.373621488068275 1252 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGR166W YGR166W TRS65 hom Verified 0.323559164779697 0.373135903960144 no 1776 0.405229071993798 1335 NA FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|CELL WALL ORG/BIOGENESIS GOLGI APPARATUS Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p; involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi; role in cell wall beta-glucan biosynthesis and the stress response intra-Golgi vesicle-mediated transport|protein complex assembly Rab guanyl-nucleotide exchange factor activity TRAPP complex|trans-Golgi network
YBR174C_d YBR174C YBR174C hom Dubious 0.322956769397763 0.373363991067764 no 1777 0.376221420854964 1238 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YBR175W; null mutant is viable and sporulation defective Unknown Unknown Unknown
YGR104C YGR104C SRB5 hom Verified 0.321762892246223 0.373816164083069 no 1778 0.389391017251176 1273 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; required for proper termination of transcription for some genes; involved in telomere maintenance transcriptional open complex formation at RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter core RNA polymerase II binding transcription factor activity|RNA polymerase II transcription factor recruiting transcription factor activity|TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly core mediator complex
YPR097W YPR097W YPR097W hom Verified 0.32170164251817 0.373839366699515 no 1779 0.390341014109852 1295 NA FT MITOCHONDRION Protein that contains a Phox homology (PX) domain and binds phosphoinositides; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process phosphatidylinositol binding mitochondrion
YPL096W YPL096W PNG1 hom Verified 0.321452957238723 0.373933578330359 no 1780 0.382925862852153 1270 NA FT RESPONSE TO DNA DAMAGE|PROTEOLYSIS NUCLEUS|MITOCHONDRION Conserved peptide N-glycanase required for deglycosylation of misfolded glycoproteins during proteasome-dependent degradation; localizes to the cytoplasm and nucleus; activity is enhanced by interaction with Rad23p misfolded or incompletely synthesized protein catabolic process|protein deglycosylation peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity cytosol|mitochondrion|nucleus
YPR072W YPR072W NOT5 hom Verified 0.321145693084552 0.374049992312522 no 1781 0.378555056590385 1252 NA FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation deadenylation-independent decapping of nuclear-transcribed mRNA|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|nuclear-transcribed mRNA poly(A) tail shortening|transcription elongation from RNA polymerase II promoter|protein ubiquitination ubiquitin-protein ligase activity CCR4-NOT core complex|cytoplasm
YDR138W YDR138W HPR1 hom Verified 0.320539197803839 0.374279810489824 no 1782 0.416678903926805 1369 NA FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION NUCLEUS RNA POL II, HOLOENZYME Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p mRNA 3'-end processing|mRNA export from nucleus|transcription-coupled nucleotide-excision repair|DNA recombination|response to DNA damage stimulus|transcription elongation from RNA polymerase II promoter protein complex scaffold|nucleic acid binding THO complex part of transcription export complex|Cdc73/Paf1 complex|nucleoplasmic THO complex
YAL053W YAL053W FLC2 hom Verified 0.319104777241146 0.374823530591554 no 1783 0.388630613646607 1316 NA FT CELL WALL ORG/BIOGENESIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication protein folding|fungal-type cell wall biogenesis|FAD transport|transmembrane transport FAD transmembrane transporter activity integral to membrane|endoplasmic reticulum|cytoplasm
YLR371W YLR371W ROM2 hom Verified 0.319024291730273 0.374854046177174 no 1784 0.439935815878811 1454 NA FF|FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|CELL WALL ORG/BIOGENESIS|NUCLEOTIDE METABOLISM SITE OF POLARIZED GROWTH GDP/GTP exchange factor (GEF) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEF; Rom2p localization to the bud surface is dependent on Ack1p regulation of fungal-type cell wall organization|positive regulation of endocytosis|establishment of cell polarity|small GTPase mediated signal transduction|negative regulation of cAMP-mediated signaling|activation of Rho GTPase activity phosphatidylinositol-4,5-bisphosphate binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity incipient cellular bud site|mating projection tip|cellular bud tip
YBR289W YBR289W SNF5 hom Verified 0.318655184325898 0.374994001009299 no 1785 0.41248819435549 1342 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS NUCLEUS|CHROMOSOME RSC COMPLEX Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf6p; relocates to the cytosol under hypoxic conditions sucrose catabolic process|double-strand break repair via homologous recombination|chromatin remodeling|carbon catabolite activation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II activating transcription factor binding SWI/SNF complex|nucleus
YBR133C YBR133C HSL7 hom Verified 0.3183200318899 0.375121095362028 no 1786 0.379764388227635 1284 NA FT CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION SITE OF POLARIZED GROWTH Protein arginine N-methyltransferase; exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p; relocalizes away from bud neck upon DNA replication stress G2/M transition of mitotic cell cycle|regulation of cell cycle protein-arginine omega-N symmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity cellular bud neck
YAL005C YAL005C SSA1 hom Verified 0.318276254209388 0.375137697454218 no 1787 0.344362564699609 1148 NA FT PROTEIN LOCALIZATION|TRANSLATION|MITOCHONDRION ORGANIZATION NUCLEUS ATPase involved in protein folding and NLS-directed nuclear transport; member of HSP70 family; forms chaperone complex with Ydj1p; localized to nucleus, cytoplasm, and cell wall; 98% identical with paralog Ssa2p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes; general targeting factor of Hsp104p to prion fibrils cytoplasmic translation|protein folding|protein refolding|protein targeting to mitochondrion|SRP-dependent cotranslational protein targeting to membrane, translocation|protein import into nucleus, translocation|response to stress unfolded protein binding|ATPase activity fungal-type vacuole membrane|fungal-type cell wall|plasma membrane|nucleus|polysome|chaperonin-containing T-complex|cytoplasm
YKL118W_d YKL118W YKL118W hom Dubious 0.318019742750613 0.375234980597273 no 1788 0.458120463121561 1507 NA FF Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene VPH2 Unknown Unknown Unknown
YDR176W YDR176W NGG1 hom Verified 0.317981095931202 0.375249638268226 no 1789 0.399327559637723 1326 NA FF|FT CHROMATIN ORGANIZATION NUCLEUS HISTONE ACETYLTRANSFERASE Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA complex, and the SLIK complex histone acetylation|chromatin modification histone acetyltransferase activity|transcription cofactor activity SLIK (SAGA-like) complex|Ada2/Gcn5/Ada3 transcription activator complex|SAGA complex
YKR005C_p YKR005C YKR005C hom Uncharacterized 0.31791562503628 0.375274469981026 no 1790 0.367828268340821 1232 NA Putative protein of unknown function biological_process molecular_function cellular_component
YDL009C_p YDL009C YDL009C hom Uncharacterized 0.317911033727634 0.375276211385777 no 1791 0.373654296040147 1237 NA Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the verified ORF YDL010W; YDL009C is not an essential gene biological_process molecular_function cellular_component
YGL007C-A_p YGL007C-A YGL007C-A hom Uncharacterized 0.316692418247594 0.375738501135945 no 1792 0.374577790417027 1237 NA Putative protein of unknown function, identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; deletion exhibits slow-growth phenotype; computationally predicted to have a role in cell budding biological_process molecular_function cellular_component
YLR375W YLR375W STP3 hom Verified 0.316652509615193 0.375753643757593 no 1793 0.385387581682551 1237 NA FT NUCLEUS Zinc-finger protein of unknown function, possibly involved in pre-tRNA splicing and in uptake of branched-chain amino acids biological_process sequence-specific DNA binding nucleus
YLR079W YLR079W SIC1 hom Verified 0.31660153777757 0.375772984394225 no 1794 0.386165481367657 1255 NA FT CELL CYCLE|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS NUCLEUS Cyclin-dependent kinase inhibitor (CKI); inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1 regulation of cyclin-dependent protein kinase activity|negative regulation of macroautophagy|G1/S transition of mitotic cell cycle cyclin-dependent protein kinase inhibitor activity nucleus|cytoplasm
YPL103C YPL103C FMP30 hom Verified 0.316106008314863 0.375961023211294 no 1795 0.387254780885657 1267 NA FT LIPID METABOLISM MITOCHONDRION Mitochondrial inner membrane protein with a role in maintaining mitochondrial morphology and normal cardiolipin levels; proposed to be involved in N-acylethanolamine metabolism; related to mammalian N-acylPE-specific phospholipase D N-acylphosphatidylethanolamine metabolic process|N-acylethanolamine metabolic process NAPE-specific phospholipase D activity mitochondrion|integral to mitochondrial inner membrane
YBL005W YBL005W PDR3 hom Verified 0.315998590554099 0.376001788969811 no 1796 0.366659386591195 1233 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Transcriptional activator of the pleiotropic drug resistance network; regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements); post-translationally up-regulated in cells lacking a functional mitochondrial genome; PDR3 has a paralog, PDR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress Unknown|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus|cytoplasm
YPR062W YPR062W FCY1 hom Verified 0.315925827474176 0.376029403831381 no 1797 0.388318409579761 1263 NA FT NUCLEUS Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU) cytosine metabolic process|pyrimidine-containing compound salvage|cytidine metabolic process cytosine deaminase activity nucleus|cytoplasm
YOL153C YOL153C YOL153C hom pseudogene 0.315880984602614 0.376046422801684 no 1798 0.354416982507848 1203 NA Hypothetical protein biological_process molecular_function cellular_component
YML099C YML099C ARG81 hom Verified 0.315620922501827 0.376145127503584 no 1799 0.367969911820555 1253 NA FT VESICLE-MEDIATED TRANSPORT|TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type, involved in the regulation of arginine-responsive genes; acts with Arg80p and Arg82p arginine metabolic process|negative regulation of calcium ion-dependent exocytosis transcription cofactor activity nucleus
YKL073W YKL073W LHS1 hom Verified 0.315290134583347 0.376270687387545 no 1800 0.390928408648243 1279 NA FT PROTEIN LOCALIZATION|NUCLEOTIDE METABOLISM ENDOPLASMIC RETICULUM Molecular chaperone of the endoplasmic reticulum lumen, involved in polypeptide translocation and folding; nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; regulated by the unfolded protein response pathway posttranslational protein targeting to membrane, translocation|response to unfolded protein unfolded protein binding|adenyl-nucleotide exchange factor activity|ATP binding endoplasmic reticulum lumen
YDR207C YDR207C UME6 hom Verified 0.314961912533074 0.376395286267759 no 1801 0.428885745694112 1416 NA FF|FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS NUCLEUS|CHROMOSOME Key transcriptional regulator of early meiotic genes, binds URS1 upstream regulatory sequence, couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms complex with Ime1p, and also with Sin3p-Rpd3p spore germination|positive regulation of transcription from RNA polymerase II promoter during meiosis|negative regulation of transcription from RNA polymerase II promoter during meiosis|lipid particle organization|nitrogen catabolite repression of transcription from RNA polymerase II promoter|pseudohyphal growth|negative regulation of transcription from RNA polymerase II promoter during mitosis|Unknown RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|repressing transcription factor binding|transcription factor binding transcription factor activity Rpd3L-Expanded complex|Rpd3L complex
YML053C_p YML053C YML053C hom Uncharacterized 0.314751005728691 0.376475357009902 no 1802 0.372962920777513 1225 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene biological_process molecular_function nucleus|cytoplasm
YNL197C YNL197C WHI3 hom Verified 0.314347822408374 0.376628440298222 no 1803 0.376700979270948 1253 NA FT PROTEIN LOCALIZATION|CELL CYCLE RNA binding protein that sequesters CLN3 mRNA in cytoplasmic foci;; Tpk1 (PKA) mediated phosphorylation of Whi3 affects G1/S transition by modulating Cln3 transcription; cytoplasmic retention factor for Cdc28p and associated cyclins; regulates cell fate and dose-dependently regulates the critical cell size required for passage through Start; WHI3 has a paralog, WHI4, that arose from the whole genome duplication pseudohyphal growth|invasive growth in response to glucose limitation|regulation of cell size|cytoplasmic sequestering of protein RNA binding cytoplasm
YDL024C YDL024C DIA3 hom Verified 0.314173738712482 0.376694543536814 no 1804 0.39367012524785 1312 NA Protein of unknown function, involved in invasive and pseudohyphal growth pseudohyphal growth|invasive growth in response to glucose limitation acid phosphatase activity fungal-type cell wall
YEL006W YEL006W YEA6 hom Verified 0.313867521921302 0.376810829261241 no 1805 0.380316947019472 1281 NA FT MITOCHONDRION Putative mitochondrial NAD+ transporter, member of the mitochondrial carrier subfamily (see also YIA6); has putative human ortholog transport|NAD transmembrane transport transporter activity|NAD transporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YBR282W YBR282W MRPL27 hom Verified 0.313742699944185 0.3768582335726 no 1806 0.376649824473331 1271 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit; homolog of human Bcl-2 interacting protein BMRP mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YFR019W YFR019W FAB1 hom Verified 0.312792444600487 0.37721917795398 no 1807 0.391623604772564 1283 NA FT LIPID METABOLISM MITOCHONDRION 1-phosphatidylinositol-3-phosphate 5-kinase; vacuolar membrane kinase that generates phosphatidylinositol (3,5)P2, which is involved in vacuolar sorting and homeostasis phosphatidylinositol phosphorylation 1-phosphatidylinositol-3-phosphate 5-kinase activity|phosphatidylinositol-3-phosphate binding endosome membrane|mitochondrion|fungal-type vacuole membrane|PAS complex
YLR335W YLR335W NUP2 hom Verified 0.312511961929112 0.377325736835358 no 1808 0.394095587813265 1328 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION|GENE SILENCING ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION|CHROMOSOME NUCLEAR PORE Nucleoporin involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization rRNA export from nucleus|snRNA export from nucleus|nuclear pore organization|tRNA export from nucleus|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|mRNA-binding (hnRNP) protein import into nucleus|ribosomal protein import into nucleus|snRNP protein import into nucleus|chromatin silencing at telomere|chromatin silencing at silent mating-type cassette|protein targeting to membrane|poly(A)+ mRNA export from nucleus|protein export from nucleus|mRNA export from nucleus in response to heat stress|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery|NLS-bearing substrate import into nucleus|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, non-stop decay nucleocytoplasmic transporter activity nuclear chromatin|mitochondrion|integral to membrane|nuclear pore
YLR306W YLR306W UBC12 hom Verified 0.312439487989772 0.377353272111932 no 1809 0.368788948407099 1215 NA Enzyme that mediates the conjugation of Rub1p, a ubiquitin-like protein, to other proteins; related to E2 ubiquitin-conjugating enzymes protein neddylation NEDD8 ligase activity cellular_component
YOL076W YOL076W MDM20 hom Verified 0.312130009994862 0.377470860180402 no 1810 0.416858112877323 1388 NA FF|FT MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly mitochondrion inheritance|N-terminal peptidyl-methionine acetylation|cytoskeleton organization peptide alpha-N-acetyltransferase activity NatB complex
YDR494W YDR494W RSM28 hom Verified 0.311141932875996 0.377846362140424 no 1811 0.378510381548912 1252 NA FT TRANSLATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit; genetic interactions suggest a possible role in promoting translation initiation cytoplasmic translation|translational initiation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YPL105C YPL105C SYH1 hom Verified 0.310591118215804 0.378055740058529 no 1812 0.373944058524248 1234 NA FT PROTEIN LOCALIZATION MITOCHONDRION Protein of unknown function that influences nuclear pore distribution; co-purifies with ribosomes; contains a GYF domain, which bind proline-rich sequences; deletion extends chronological lifespan; SYH1 has a paralog, SMY2, that arose from the whole genome duplication nuclear pore distribution molecular_function mitochondrion|ribosome|cytoplasmic mRNA processing body|extrinsic to membrane|cytoplasm
YIL039W YIL039W TED1 hom Verified 0.309918687929914 0.378311395559614 no 1813 0.399319739721569 1290 NA FT VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) ER to Golgi vesicle-mediated transport molecular_function endoplasmic reticulum
YGL019W YGL019W CKB1 hom Verified 0.309175438831649 0.378594038103203 no 1814 0.398273359033203 1304 NA FF|FT RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION NUCLEUS Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases regulation of transcription from RNA polymerase I promoter|protein phosphorylation|regulation of transcription from RNA polymerase III promoter|response to DNA damage stimulus protein kinase regulator activity|protein serine/threonine kinase inhibitor activity protein kinase CK2 complex|UTP-C complex
YPL199C_p YPL199C YPL199C hom Uncharacterized 0.308676090211377 0.378783966735677 no 1815 0.379256818641905 1260 NA Putative protein of unknown function, predicted to be palmitoylated biological_process molecular_function cytoplasm
YJR116W_p YJR116W TDA4 hom Uncharacterized 0.307778317504621 0.379125510682226 no 1816 0.342054459151283 1120 NA Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele biological_process molecular_function integral to membrane
YNL269W YNL269W BSC4 hom Verified 0.307028916089489 0.379410681319537 no 1817 0.382138002941953 1275 NA Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough is increased upon depletion of Sup35p biological_process molecular_function cellular_component
YLR210W YLR210W CLB4 hom Verified 0.306798144212964 0.379498510446021 no 1818 0.376816983242562 1227 NA FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION NUCLEUS|CYTOSKELETON B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation G2/M transition of mitotic cell cycle|S phase of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|positive regulation of spindle pole body separation cyclin-dependent protein kinase regulator activity nucleus|spindle pole body|cytoplasm
YCR019W YCR019W MAK32 hom Verified 0.306442061472208 0.379634043647542 no 1819 0.379069311576808 1282 NA Protein necessary for structural stability of L-A double-stranded RNA-containing particles interspecies interaction between organisms molecular_function cellular_component
YDL159W-A_p YDL159W-A YDL159W-A hom Uncharacterized 0.30601262650977 0.379797516047823 no 1820 0.37993295695874 1248 NA Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species biological_process molecular_function cellular_component
YLL052C YLL052C AQY2 hom Verified 0.305086262933164 0.380150226683461 no 1821 0.377725826704418 1258 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains water transport water channel activity plasma membrane|endoplasmic reticulum membrane
YJL141C YJL141C YAK1 hom Verified 0.304897756427134 0.380222012285232 no 1822 0.375588223495 1240 NA FT PROTEIN PHOSPHORYLATION NUCLEUS Serine-threonine protein kinase; component of a glucose-sensing system that inhibits growth in response to glucose availability; upon nutrient deprivation Yak1p phosphorylates Pop2p to regulate mRNA deadenylation, the co-repressor Crf1p to inhibit transcription of ribosomal genes, and the stress-responsive transcription factors Hsf1p and Msn2p; nuclear localization negatively regulated by the Ras/PKA signaling pathway in the presence of glucose protein phosphorylation protein serine/threonine kinase activity|protein tyrosine kinase activity|protein kinase activity nucleus|cytoplasm
YEL040W YEL040W UTR2 hom Verified 0.301581837470983 0.381485427649288 no 1823 0.373712392464966 1251 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM SITE OF POLARIZED GROWTH|CYTOSKELETON Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck cell wall chitin metabolic process|fungal-type cell wall organization transferase activity, transferring glycosyl groups cellular bud neck septin ring|fungal-type cell wall
YGR018C_p YGR018C YGR018C hom Uncharacterized 0.301050782811011 0.381687885283416 no 1824 0.370785692988286 1221 NA Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the uncharacterized ORF YGR017W biological_process molecular_function cellular_component
YOL105C YOL105C WSC3 hom Verified 0.301012913078225 0.38170232386017 no 1825 0.367066078257237 1251 NA FT SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|PEROXISOME ORGANIZATION SITE OF POLARIZED GROWTH Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity; involved in the response to heat shock and other stressors; regulates 1,3-beta-glucan synthesis response to heat|peroxisome degradation|Rho protein signal transduction transmembrane signaling receptor activity mating projection tip
YEL025C_p YEL025C YEL025C hom Uncharacterized 0.30024679715592 0.381994455868242 no 1826 0.357125595806761 1194 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus biological_process molecular_function nucleus|cytoplasm
YGL084C YGL084C GUP1 hom Verified 0.299998612157401 0.382089107117414 no 1827 0.474461576909181 1555 NA FF|FT LIPID METABOLISM|CARBOHYDRATE METABOLISM ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; proposed to be involved in glycerol transport GPI anchor biosynthetic process|glycerol transport|glycerol catabolic process O-acyltransferase activity integral to membrane|endoplasmic reticulum|plasma membrane|membrane
YOR007C YOR007C SGT2 hom Verified 0.299965729676453 0.382101648162066 no 1828 0.373835943846032 1251 NA FT PROTEIN LOCALIZATION Glutamine-rich cytoplasmic cochaperone; serves as a scaffold bringing together Get4, Get5p, and other TRC complex members that are required to mediate posttranslational insertion of tail-anchored proteins into the ER membrane; interacts with the prion domain of Sup35p; amyloid sensor; plays a role in targeting chaperones to prion aggregates; has similarity to human cochaperone SGT; forms cytoplasmic foci upon DNA replication stress response to heat|posttranslational protein targeting to membrane molecular_function TRC complex|cytoplasm
YJR135W-A YJR135W-A TIM8 hom Verified 0.298811739406687 0.382541846601688 no 1829 0.367375265906726 1212 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial intermembrane space protein, forms a complex with Tim13p that delivers a subset of hydrophobic proteins to the TIM22 complex for inner membrane insertion; homolog of human TIMM8A, implicated in Mohr-Tranebjaerg syndrome protein import into mitochondrial inner membrane protein transporter activity mitochondrion|integral to membrane|mitochondrial intermembrane space protein transporter complex
YGL229C YGL229C SAP4 hom Verified 0.298495617652453 0.38266246018279 no 1830 0.389792755011693 1255 NA FT CELL CYCLE MITOCHONDRION Protein required for function of the Sit4p protein phosphatase, member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p G1/S transition of mitotic cell cycle protein serine/threonine phosphatase activity mitochondrion|cytoplasm
YIL097W YIL097W FYV10 hom Verified 0.298302970315901 0.382735968726596 no 1831 0.389253688995138 1305 NA FT KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS NUCLEUS Subunit of GID complex; involved in proteasome-dependent catabolite inactivation of gluconeogenic enzymes FBPase, PEPCK, and c-MDH; forms dimer with Rmd5p that is then recruited to GID Complex by Gid8p; contains a degenerate RING finger motif needed for GID complex ubiquitin ligase activity in vivo, as well as CTLH and CRA domains; plays role in anti-apoptosis; required for survival upon exposure to K1 killer toxin negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis ubiquitin-protein ligase activity nucleus|GID complex|cytoplasm
YLR264C-A_p YLR264C-A YLR264C-A hom Uncharacterized 0.296979211808403 0.383241190058581 no 1832 0.380808806790315 1247 NA Putative protein of unknown function biological_process molecular_function cellular_component
YHR154W YHR154W RTT107 hom Verified 0.296510363324912 0.383420176915355 no 1833 0.401473648007688 1327 NA FT RESPONSE TO DNA DAMAGE NUCLEUS UBIQUITIN LIGASE COMPLEX Protein implicated in Mms22-dependent DNA repair during S phase; involved in recruiting the SMC5/6 complex to double-strand breaks; DNA damage induces phosphorylation by Mec1p at one or more SQ/TQ motifs; interacts with Mms22p and Slx4p; has four BRCT domains; has a role in regulation of Ty1 transposition; relative distribution to nuclear foci increases upon DNA replication stress negative regulation of transposition, RNA-mediated|double-strand break repair molecular_function Cul8-RING ubiquitin ligase complex|nucleus
YGR279C YGR279C SCW4 hom Verified 0.296472204758786 0.383434745364844 no 1834 0.390459359708258 1283 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating conjugation with cellular fusion glucosidase activity extracellular region|fungal-type cell wall
YDR492W YDR492W IZH1 hom Verified 0.295922972210978 0.383644453532374 no 1835 0.380716634172369 1275 NA FT LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc response to zinc ion|cellular zinc ion homeostasis|cellular lipid metabolic process metal ion binding integral to membrane|endoplasmic reticulum|membrane
YBR273C YBR273C UBX7 hom Verified 0.295413504429814 0.383839009177986 no 1836 0.377161107367795 1250 NA FT PROTEOLYSIS ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p; UBX7 has a paralog, UBX6, that arose from the whole genome duplication sporulation resulting in formation of a cellular spore|ubiquitin-dependent protein catabolic process molecular_function nuclear envelope|endoplasmic reticulum
YDR435C YDR435C PPM1 hom Verified 0.294930058415826 0.384023654705502 no 1837 0.409289136840604 1348 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS Carboxyl methyltransferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits cellular protein complex assembly|C-terminal protein methylation protein C-terminal leucine carboxyl O-methyltransferase activity cellular_component
YDL012C YDL012C YDL012C hom Verified 0.294724678215294 0.384102104807144 no 1838 0.358394057063763 1189 NA FT PLASMA MEMBRANE Tail-anchored plasma membrane protein with a conserved CYSTM module; possibly involved in response to stress; may contribute to non-homologous end-joining (NHEJ) based on ydl012c htz1 double null phenotype; YDL012C has a paralog, YBR016W, that arose from the whole genome duplication biological_process molecular_function plasma membrane
YIL110W YIL110W HPM1 hom Verified 0.294153296318237 0.384320383379816 no 1839 0.372263825688901 1223 NA FT NUCLEUS AdoMet-dependent methyltransferase involved in a novel 3-methylhistidine modification of ribosomal protein Rpl3p; seven beta-strand MTase family member; null mutant exhibits a weak vacuolar protein sorting defect and caspofungin resistance peptidyl-histidine methylation, to form tele-methylhistidine S-adenosylmethionine-dependent methyltransferase activity|protein-histidine N-methyltransferase activity nucleus|cytoplasm
YBL071C_d YBL071C YBL071C hom Dubious 0.293439963035338 0.384592941524483 no 1840 0.3744311834125 1212 NA Dubious open reading frame, predicted protein contains a peroxisomal targeting signal Unknown Unknown Unknown
YLR341W YLR341W SPO77 hom Verified 0.291361047551603 0.385387601173889 no 1841 0.389149380560137 1271 NA FT CELL WALL ORG/BIOGENESIS Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis ascospore wall assembly|ascospore formation molecular_function intracellular
YGR226C_d YGR226C YGR226C hom Dubious 0.289925126717148 0.385936759233678 no 1842 0.389629522163314 1291 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; overlaps significantly with a verified ORF, AMA1/YGR225W Unknown Unknown Unknown
YMR276W YMR276W DSK2 hom Verified 0.289413920540111 0.386132321773832 no 1843 0.346076531874489 1137 NA FT CELL CYCLE|PROTEOLYSIS|CYTOSKELETON ORGANIZATION NUCLEUS Nuclear-enriched ubiquitin-like polyubiquitin-binding protein; required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle; involved in proteolysis; interacts with the proteasome; protein abundance increases in response to DNA replication stress ER-associated protein catabolic process|spindle pole body duplication associated with nuclear envelope protein binding, bridging nucleus
YKR011C YKR011C YKR011C hom Verified 0.288443432139365 0.386503662853151 no 1844 0.38374698927997 1254 NA FT NUCLEUS Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus
YER053C-A YER053C-A YER053C-A hom Verified 0.287621945151555 0.386818072305224 no 1845 0.377926067216045 1278 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress biological_process molecular_function endoplasmic reticulum
YBR067C YBR067C TIP1 hom Verified 0.286719698506763 0.38716347667605 no 1846 0.397095329497099 1307 NA FT CELL WALL ORG/BIOGENESIS Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins fungal-type cell wall organization structural constituent of cell wall|lipase activity fungal-type cell wall
YHL047C YHL047C ARN2 hom Verified 0.286235576505396 0.387348848502989 no 1847 0.388080553970524 1275 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS|COFACTOR METABOLISM PLASMA MEMBRANE Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C cellular iron ion homeostasis|siderophore transport|siderophore metabolic process siderophore transmembrane transporter activity endosome|integral to membrane|cytoplasmic membrane-bounded vesicle|plasma membrane
YIR034C YIR034C LYS1 hom Verified 0.285767236861713 0.387528201663016 no 1848 0.405274135677857 1346 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS Saccharopine dehydrogenase (NAD+, L-lysine-forming), catalyzes the conversion of saccharopine to L-lysine, which is the final step in the lysine biosynthesis pathway; also has mRNA binding activity lysine biosynthetic process|lysine biosynthetic process via aminoadipic acid saccharopine dehydrogenase (NAD+, L-lysine-forming) activity|mRNA binding cytoplasm
YIL017C YIL017C VID28 hom Verified 0.284841591461267 0.387882753072109 no 1849 0.378162908396413 1256 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS NUCLEUS GID Complex subunit, serves as adaptor for regulatory subunit Vid24p; protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); localized to the nucleus and the cytoplasm negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|vacuolar protein catabolic process|ascospore formation|positive regulation of transcription from RNA polymerase II promoter molecular_function nucleus|GID complex|cytoplasm
YPL102C_d YPL102C YPL102C hom Dubious 0.28327415890386 0.388483342276369 no 1850 0.381801203226492 1262 NA Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation enhances replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene ELP4 Unknown Unknown Unknown
YDL061C YDL061C RPS29B hom Verified 0.282872991311008 0.388637099580708 no 1851 0.373704755683909 1240 NA FT TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29B has a paralog, RPS29A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic small ribosomal subunit
YJL093C YJL093C TOK1 hom Verified 0.28269241529292 0.388706315458132 no 1852 0.392423615975459 1283 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Outward-rectifier potassium channel of the plasma membrane with two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin cellular potassium ion homeostasis potassium channel activity integral to membrane|plasma membrane
YPL195W YPL195W APL5 hom Verified 0.28255824674751 0.388757745359315 no 1853 0.403558119725495 1313 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Delta adaptin-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function vesicle-mediated transport|Golgi to vacuole transport protein binding AP-3 adaptor complex
YAL054C YAL054C ACS1 hom Verified 0.282385758652339 0.388823866893127 no 1854 0.383254970597544 1261 NA FT KETONE METABOLISM|CHROMATIN ORGANIZATION|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetylation; expressed during growth on nonfermentable carbon sources and under aerobic conditions acetate fermentation|histone acetylation|acetyl-CoA biosynthetic process acetate-CoA ligase activity|acid-ammonia (or amide) ligase activity cytosol|mitochondrion|integral to membrane
YHR011W YHR011W DIA4 hom Verified 0.282349639088314 0.388837713363679 no 1855 0.39110129018534 1326 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Probable mitochondrial seryl-tRNA synthetase, mutant displays increased invasive and pseudohyphal growth pseudohyphal growth|invasive growth in response to glucose limitation|mitochondrial seryl-tRNA aminoacylation serine-tRNA ligase activity mitochondrion|cytoplasm
YJL020C YJL020C BBC1 hom Verified 0.281180651557374 0.389285922036179 no 1856 0.370210253317869 1231 NA FT CYTOSKELETON ORGANIZATION CYTOSKELETON Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches actin cytoskeleton organization myosin I binding actin cortical patch
YNL058C_p YNL058C YNL058C hom Uncharacterized 0.281045503316968 0.389337749564248 no 1857 0.369402977959962 1231 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL058C is not an essential gene biological_process molecular_function fungal-type vacuole
YCR043C_p YCR043C YCR043C hom Uncharacterized 0.279752669057274 0.389833633434452 no 1858 0.397085014148375 1305 NA FT GOLGI APPARATUS|SITE OF POLARIZED GROWTH Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene biological_process molecular_function Golgi apparatus|mating projection tip
YBR249C YBR249C ARO4 hom Verified 0.279749810772221 0.389834729966923 no 1859 0.38773696964922 1283 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan; relative distribution to the nucleus increases upon DNA replication stress aromatic amino acid family biosynthetic process 3-deoxy-7-phosphoheptulonate synthase activity nucleus|cytoplasm
YJR024C YJR024C MDE1 hom Verified 0.279537880102395 0.389916036007773 no 1860 0.380706811107459 1250 NA FT KETONE METABOLISM|AMINO ACID METABOLISM 5'-methylthioribulose-1-phosphate dehydratase; acts in the methionine salvage pathway; potential Smt3p sumoylation substrate; expression downregulated by caspofungin and deletion mutant is caspofungin resistant L-methionine salvage from methylthioadenosine methylthioribulose 1-phosphate dehydratase activity cytoplasm
YER132C YER132C PMD1 hom Verified 0.278677169084242 0.390246292547695 no 1861 0.391982016702138 1321 NA FT CELL CYCLE Protein with an N-terminal kelch-like domain, putative negative regulator of early meiotic gene expression; required, with Mds3p, for growth under alkaline conditions sporulation resulting in formation of a cellular spore molecular_function cytoplasm
YGR249W YGR249W MGA1 hom Verified 0.278500068352123 0.390314256288198 no 1862 0.390460236913844 1311 NA FT NUCLEUS Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants filamentous growth sequence-specific DNA binding|DNA binding|sequence-specific DNA binding transcription factor activity nucleus
YMR060C YMR060C SAM37 hom Verified 0.278293623584905 0.390393485254553 no 1863 0.424368121916914 1400 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; contributes to SAM complex stability mitochondrial outer membrane translocase complex assembly|protein import into mitochondrial outer membrane|phospholipid transport molecular_function mitochondrial outer membrane|mitochondrial sorting and assembly machinery complex|mitochondrion|integral to membrane
YBR012C_d YBR012C YBR012C hom Dubious 0.277991181777548 0.390509563994303 no 1864 0.387698156772199 1269 NA Dubious open reading frame, unlikely to encode a functional protein; expression induced by iron-regulated transcriptional activator Aft2p Unknown Unknown Unknown
YDR310C YDR310C SUM1 hom Verified 0.277352588652239 0.390754691407239 no 1865 0.406417635047011 1347 NA FT TRANSCRIPTION FROM RNA POL II|GENE SILENCING NUCLEUS Transcriptional repressor required for mitotic repression of middle sporulation-specific genes; also acts as general replication initiation factor; involved in telomere maintenance, chromatin silencing; regulated by pachytene checkpoint negative regulation of transcription by competitive promoter binding|negative regulation of transcription from RNA polymerase II promoter during mitosis|DNA replication initiation|chromatin silencing at silent mating-type cassette DNA replication origin binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding nucleus
YGL138C_p YGL138C YGL138C hom Uncharacterized 0.27693074917199 0.390916640585366 no 1866 0.396974204270129 1319 NA Putative protein of unknown function; has no significant sequence similarity to any known protein biological_process molecular_function cellular_component
YIL074C YIL074C SER33 hom Verified 0.276508494001596 0.391078768299894 no 1867 0.372430461228346 1261 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS 3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER33 has a paralog, SER3, that arose from the whole genome duplication serine family amino acid biosynthetic process phosphoglycerate dehydrogenase activity cytoplasm
YHL042W_p YHL042W YHL042W hom Uncharacterized 0.276308377567284 0.391155610965088 no 1868 0.361824981025097 1187 NA Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins biological_process molecular_function cellular_component
YGR295C YGR295C COS6 hom Verified 0.276231441212711 0.39118515486977 no 1869 0.384442672087388 1243 NA Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins biological_process molecular_function integral to membrane|fungal-type vacuole
YDL026W_d YDL026W YDL026W hom Dubious 0.275894679385608 0.391314480306359 no 1870 0.399492498795455 1329 NA Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR069C YLR069C MEF1 hom Verified 0.275674051715915 0.391399213674848 no 1871 0.385577192840892 1283 NA FT TRANSLATION|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial elongation factor involved in translational elongation mitochondrial translational elongation|mitochondrial translation translation elongation factor activity mitochondrion
YML082W_p YML082W YML082W hom Uncharacterized 0.275632454333781 0.391415189974376 no 1872 0.413110652508077 1382 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Putative protein predicted to have carbon-sulfur lyase activity; transcriptionally regulated by Upc2p via an upstream sterol response element; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and the cytoplasm; YML082W is not an essential gene sulfur compound metabolic process carbon-sulfur lyase activity nucleus|cytoplasm
YIL164C YIL164C NIT1 hom Verified 0.275446557190638 0.391486589696874 no 1873 0.37140376205464 1237 NA Nitrilase, member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene biological_process nitrilase activity cellular_component
YPL013C YPL013C MRPS16 hom Verified 0.274446783171992 0.391870647421049 no 1874 0.405079524583362 1337 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YBR101C YBR101C FES1 hom Verified 0.274141745114478 0.391987847123591 no 1875 0.391130944785836 1309 NA FT TRANSLATION RIBOSOME Hsp70 (Ssa1p) nucleotide exchange factor; cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum; protein abundance increases in response to DNA replication stress cytoplasmic translation adenyl-nucleotide exchange factor activity cytosol|cytosolic ribosome
YJR117W YJR117W STE24 hom Verified 0.273931944599938 0.392068460977334 no 1876 0.381351282242572 1256 NA FT PROTEOLYSIS ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans CAAX-box protein processing|peptide pheromone maturation metalloendopeptidase activity mitochondrial outer membrane|integral to endoplasmic reticulum membrane|integral to membrane|nuclear inner membrane
YDR537C_d YDR537C YDR537C hom Dubious 0.272391004926726 0.392660694171466 no 1877 0.398792188821883 1316 NA Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W Unknown Unknown Unknown
YML129C YML129C COX14 hom Verified 0.272270774413772 0.392706913138279 no 1878 0.387224241878441 1279 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes mitochondrial respiratory chain complex IV assembly|negative regulation of mitochondrial translation molecular_function mitochondrial envelope|mitochondrion|integral to membrane|mitochondrial inner membrane|mitochondrial matrix|extrinsic to membrane
YGR236C YGR236C SPG1 hom Verified 0.272247458129362 0.392715876550402 no 1879 0.392842426893264 1309 NA FT MITOCHONDRION Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YBR056W-A_p YBR056W-A YBR056W-A hom Uncharacterized 0.272108225201857 0.39276940264826 no 1880 0.421565097201964 1379 NA Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the dubious ORF YBR056C-B biological_process molecular_function cellular_component
YNL299W YNL299W TRF5 hom Verified 0.271920499486377 0.392841574311724 no 1881 0.397791867643669 1321 NA FT CELL CYCLE|RNA PROCESSING|CELL DIVISION NUCLEUS Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Pap2p nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent snRNA catabolic process|ncRNA polyadenylation|histone mRNA catabolic process|nuclear polyadenylation-dependent mRNA catabolic process|U4 snRNA 3'-end processing|polyadenylation-dependent snoRNA 3'-end processing|snoRNA polyadenylation polynucleotide adenylyltransferase activity nucleolus|TRAMP complex
YDL216C YDL216C RRI1 hom Verified 0.271915551455779 0.392843476645431 no 1882 0.389258933680524 1295 NA FT SIGNALING|PROTEOLYSIS NUCLEUS Catalytic subunit of the COP9 signalosome (CSN) complex that acts as an isopeptidase in cleaving the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; metalloendopeptidase involved in the adaptation to pheromone signaling adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|cullin deneddylation metalloendopeptidase activity signalosome
YKL156W YKL156W RPS27A hom Verified 0.271515717894664 0.392997206232503 no 1883 0.401880527249782 1331 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27A has a paralog, RPS27B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress cytoplasmic translation|ribosomal small subunit assembly|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit|cytoplasm
YMR099C YMR099C YMR099C hom Verified 0.271354175339182 0.393059321487448 no 1884 0.405971037272639 1363 NA FT CARBOHYDRATE METABOLISM NUCLEUS Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS cellular carbohydrate metabolic process glucose-6-phosphate 1-epimerase activity nucleus|cytoplasm
YJL205C YJL205C NCE101 hom Verified 0.271202600206942 0.393117606612067 no 1885 0.368911530441917 1259 NA FT PROTEIN LOCALIZATION Protein of unknown function, involved in secretion of proteins that lack classical secretory signal sequences protein secretion molecular_function cellular_component
YGR022C_d YGR022C YGR022C hom Dubious 0.271184565231767 0.393124541753343 no 1886 0.368914186233777 1225 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W Unknown Unknown Unknown
YKL135C YKL135C APL2 hom Verified 0.270933892248321 0.39322093866328 no 1887 0.409505774805324 1364 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS|PLASMA MEMBRANE Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress Golgi to vacuole transport|vesicle-mediated transport clathrin binding AP-1 adaptor complex
YMR307W YMR307W GAS1 hom Verified 0.269976313157465 0.393589238274983 no 1888 0.406297783085881 1353 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|GENE SILENCING NUCLEUS|MITOCHONDRION|PLASMA MEMBRANE Beta-1,3-glucanosyltransferase, required for cell wall assembly and also has a role in transcriptional silencing; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor; also found at the nuclear periphery fungal-type cell wall organization|chromatin silencing|filamentous growth 1,3-beta-glucanosyltransferase activity mitochondrion|membrane raft|primary cell septum|nuclear periphery|integral to membrane|fungal-type cell wall|plasma membrane|cellular bud scar|ER to Golgi transport vesicle
YHR059W YHR059W FYV4 hom Verified 0.268586270615509 0.39412403932918 no 1889 0.378688844131101 1253 NA FT MITOCHONDRION Protein of unknown function, required for survival upon exposure to K1 killer toxin biological_process molecular_function mitochondrion
YBR197C YBR197C YBR197C hom Verified 0.268493974070835 0.394159556322705 no 1890 0.397435769875014 1317 NA FT NUCLEUS Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR197C is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress; YBR197C has a paralog, YPL077C, that arose from the whole genome duplication biological_process molecular_function nucleus|cytoplasm
YLR164W YLR164W SHH4 hom Verified 0.26739064137276 0.394584202154062 no 1891 0.371702367013863 1248 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Mitochondrial inner membrane protein of unknown function; similar to Tim18p and Sdh4p; a fraction copurifies with Sdh3p, but Shh4p is neither a stoichiometric subunit of succinate dehydrogenase nor of the TIM22 translocase; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner biological_process molecular_function mitochondrion|mitochondrial inner membrane
YKL190W YKL190W CNB1 hom Verified 0.266445550839541 0.394948044086751 no 1892 0.393719032695908 1318 NA FF|FT SIGNALING|ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1; protein abundance increases in response to DNA replication stress adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|fungal-type cell wall organization|cellular ion homeostasis calcium-dependent protein serine/threonine phosphatase activity|calcium ion binding calcineurin complex
YHR063C YHR063C PAN5 hom Verified 0.265444375804067 0.39533357743312 no 1893 0.410808381862676 1354 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM 2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panE pantothenate biosynthetic process 2-dehydropantoate 2-reductase activity cytoplasm
YFR047C YFR047C BNA6 hom Verified 0.265333885483385 0.395376131426091 no 1894 0.394188282756988 1298 NA FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM NUCLEUS Quinolinate phosphoribosyl transferase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p de novo NAD biosynthetic process from tryptophan nicotinate-nucleotide diphosphorylase (carboxylating) activity nucleus|cytoplasm
YDL076C YDL076C RXT3 hom Verified 0.265015644871091 0.395498704867731 no 1895 0.400665199047967 1327 NA FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Subunit of the RPD3L complex; involved in histone deacetylation; protein abundance increases in response to DNA replication stress negative regulation of transcription from RNA polymerase I promoter molecular_function Rpd3L-Expanded complex|nucleus|Rpd3L complex
YHR157W YHR157W REC104 hom Verified 0.263896355054687 0.395929892182602 no 1896 0.383813489591785 1268 NA FT CELL CYCLE NUCLEUS|CHROMOSOME Protein involved in early stages of meiotic recombination; required for meiotic crossing over; forms a complex with Rec102p and Spo11p necessary during the initiation of recombination meiotic DNA double-strand break formation|reciprocal meiotic recombination molecular_function condensed nuclear chromosome
YJL209W YJL209W CBP1 hom Verified 0.262941489578364 0.396297838531018 no 1897 0.385497444498316 1258 NA FT RNA PROCESSING|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Mitochondrial protein, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex at the inner membrane along with Pet309p; localizes to mitochondrial foci upon DNA replication stress mitochondrial mRNA catabolic process|aerobic respiration mRNA binding mitochondrion|extrinsic to mitochondrial inner membrane
YLR444C_d YLR444C YLR444C hom Dubious 0.262339101865625 0.39653000920603 no 1898 0.392541230584638 1296 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOL014W_p YOL014W YOL014W hom Uncharacterized 0.261679717566236 0.396784189416232 no 1899 0.421530546124677 1393 NA Putative protein of unknown function biological_process molecular_function cellular_component
YOL086W-A YOL086W-A MHF1 hom Verified 0.261054833148559 0.397025111054028 no 1900 0.382104459157092 1296 NA FT RESPONSE TO DNA DAMAGE Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM, a Fanconi anemia complementation group protein, to stabilize and remodel blocked replication forks and repair damaged DNA; mhf1 srs2 double mutants are MMS hypersensitive; ortholog of human centromere constitutive-associated network (CCAN) subunit CENP-S, also known as MHF1 response to DNA damage stimulus molecular_function cellular_component
YPL090C YPL090C RPS6A hom Verified 0.260804957652804 0.397121460537707 no 1901 0.399791893420356 1334 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; RPS6A has a paralog, RPS6B, that arose from the whole genome duplication cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome small-subunit processome|cytosolic small ribosomal subunit|90S preribosome
YOL052C YOL052C SPE2 hom Verified 0.260736211492792 0.397147969468793 no 1902 0.40760099071475 1345 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM NUCLEUS S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically spermidine biosynthetic process|spermine biosynthetic process|pantothenate biosynthetic process adenosylmethionine decarboxylase activity nucleus|cytoplasm
YDL113C YDL113C ATG20 hom Verified 0.260645217515587 0.397183058022145 no 1903 0.389909259571877 1288 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Sorting nexin family member required for the cytoplasm-to-vacuole targeting (Cvt) pathway and for endosomal sorting; has a Phox homology domain that binds phosphatidylinositol-3-phosphate; interacts with Snx4p; potential Cdc28p substrate mitochondrion degradation|early endosome to Golgi transport|macroautophagy|CVT pathway phosphatidylinositol-3-phosphate binding endosome|pre-autophagosomal structure|extrinsic to membrane
YOR073W YOR073W SGO1 hom Verified 0.260327984471142 0.397305394038108 no 1904 0.400310711490142 1311 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME|CYTOSKELETON KINETOCHORE Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability positive regulation of maintenance of meiotic sister chromatid cohesion|meiotic sister chromatid segregation|meiotic sister chromatid separation|sister chromatid biorientation|maintenance of meiotic sister chromatid cohesion|mitotic cell cycle spindle assembly checkpoint|mitotic sister chromatid segregation molecular_function condensed nuclear chromosome kinetochore|nucleus|spindle pole body|condensed nuclear chromosome, centromeric region
YDL240W YDL240W LRG1 hom Verified 0.260085754251974 0.397398813178164 no 1905 0.404259430507563 1338 NA FT SIGNALING|CELL WALL ORG/BIOGENESIS MITOCHONDRION|SITE OF POLARIZED GROWTH Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity; appears to specifically regulate 1,3-beta-glucan synthesis fungal-type cell wall biogenesis|small GTPase mediated signal transduction Rho GTPase activator activity mitochondrion|cellular bud neck|cytoplasm
YDL057W_p YDL057W YDL057W hom Uncharacterized 0.259984281501135 0.397437949174228 no 1906 0.375242842637804 1255 NA Putative protein of unknown function; YDL057W is not an essential gene biological_process molecular_function cellular_component
YHR050W-A_p YHR050W-A YHR050W-A hom Uncharacterized 0.259950959544372 0.397450801006968 no 1907 0.40131417888299 1323 NA Protein of unknown function; identified by expression profiling and mass spectrometry biological_process molecular_function cellular_component
YDR457W YDR457W TOM1 hom Verified 0.259295244530675 0.397703724144094 no 1908 0.37265533476572 1242 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|PROTEOLYSIS|RNA LOCALIZATION NUCLEUS E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones; interacts with Dia2p and is required for Dia2p degradation; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|mitosis|nucleocytoplasmic transport|nucleus organization|cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|regulation of cell size|protein ubiquitination ubiquitin-protein ligase activity integral to membrane|nucleolus|nucleus
YKL100C_p YKL100C YKL100C hom Uncharacterized 0.258380160052892 0.398056763430134 no 1909 0.38264861138035 1277 NA FT PROTEOLYSIS Putative protein of unknown function with similarity to a human minor histocompatibility antigen and signal peptide peptidases; YKL100C is not an essential gene biological_process molecular_function integral to membrane
YNL027W YNL027W CRZ1 hom Verified 0.258231489883636 0.398114128222368 no 1910 0.388681030917626 1294 NA FT TRANSCRIPTION FROM RNA POL II|SIGNALING|ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|ION HOMEOSTASIS NUCLEUS Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress regulation of potassium ion concentration by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter in response to calcium ion|positive regulation of sodium ion transport by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter in response to increased salt|cell wall chitin biosynthetic process|positive regulation of transcription from RNA polymerase II promoter in response to alkalinity|positive regulation of transcription from RNA polymerase II promoter by pheromones|ion homeostasis|Unknown|positive regulation of transcription from RNA polymerase II promoter core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus|cytoplasm
YGR127W_p YGR127W YGR127W hom Uncharacterized 0.257889045562466 0.398246269678995 no 1911 0.390755894101426 1305 NA Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response biological_process molecular_function cellular_component
YKL150W YKL150W MCR1 hom Verified 0.257782608088637 0.398287343851678 no 1912 0.425317494437859 1404 NA FT LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS MITOCHONDRION Mitochondrial NADH-cytochrome b5 reductase, involved in ergosterol biosynthesis ergosterol biosynthetic process|cellular response to oxidative stress cytochrome-b5 reductase activity mitochondrial outer membrane|mitochondrion|integral to mitochondrial outer membrane|mitochondrial intermembrane space
YBL093C YBL093C ROX3 hom Verified 0.257106675215641 0.398548212325365 no 1913 0.410789469059124 1336 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme negative regulation of transcription from RNA polymerase II promoter|transcriptional open complex formation at RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription factor recruiting transcription factor activity core mediator complex|nucleus
YMR144W_p YMR144W YMR144W hom Uncharacterized 0.256532309301606 0.398769917842581 no 1914 0.395691436297036 1287 NA FT NUCLEUS Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene biological_process molecular_function nucleus
YHR082C YHR082C KSP1 hom Verified 0.256182125655442 0.398905104932563 no 1915 0.403403470989855 1343 NA FT PROTEIN LOCALIZATION|SIGNALING|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS NUCLEUS Serine/threonine protein kinase; associates with TORC1 and likely involved in TOR signaling cascades; negative regulator of autophagy; nuclear translocation required for haploid filamentous growth; regulates filamentous growth induced nuclear translocation of Bcy1p, Fus3p, and Sks1p; overproduction causes allele-specific suppression of prp20-10; protein abundance increases in response to DNA replication stress TOR signaling cascade|protein phosphorylation|Unknown|cellular protein localization|regulation of filamentous growth|negative regulation of macroautophagy protein serine/threonine kinase activity|protein kinase activity nucleus|cytoplasm
YJL213W YJL213W YJL213W hom Verified 0.256031780669743 0.39896314877553 no 1916 0.393819479964516 1298 NA Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p biological_process molecular_function ribosome
YLR443W YLR443W ECM7 hom Verified 0.255852767991716 0.399032263297811 no 1917 0.399073710332114 1348 NA FT ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency fungal-type cell wall organization|calcium ion transport molecular_function integral to membrane
YLR255C_d YLR255C YLR255C hom Dubious 0.25557838999652 0.399138203301972 no 1918 0.416318355220071 1377 NA Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPL108W_p YPL108W YPL108W hom Uncharacterized 0.255549693039708 0.399149283904502 no 1919 0.403657341093071 1352 NA Cytoplasmic protein of unknown function; non-essential gene that is induced in a GDH1 deleted strain with altered redox metabolism; GFP-fusion protein is induced in response to the DNA-damaging agent MMS biological_process molecular_function cytoplasm
YOR371C YOR371C GPB1 hom Verified 0.254523368563374 0.399545626445236 no 1920 0.396585138738708 1330 NA FT SIGNALING|PROTEOLYSIS PLASMA MEMBRANE Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; promotes ubiquitin-dependent proteolysis of Ira2p; regulated by G-alpha protein Gpa2p; GPB1 has a paralog, GPB2, that arose from the whole genome duplication positive regulation of Ras protein signal transduction|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of phosphorylation|signal transduction|glucose mediated signaling pathway|pseudohyphal growth|invasive growth in response to glucose limitation|negative regulation of Ras protein signal transduction|protein polyubiquitination cAMP-dependent protein kinase inhibitor activity|signal transducer activity|GTPase activating protein binding plasma membrane|cytoplasm
YBR036C YBR036C CSG2 hom Verified 0.254447078914147 0.399575091865231 no 1921 0.405649711701951 1328 NA FF|FT LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Endoplasmic reticulum membrane protein, required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations; protein abundance increases in response to DNA replication stress cellular calcium ion homeostasis|glycosphingolipid biosynthetic process enzyme regulator activity integral to endoplasmic reticulum membrane|integral to membrane
YDR400W YDR400W URH1 hom Verified 0.254030501374155 0.39973599706875 no 1922 0.394954468407722 1293 NA FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM NUCLEUS Uridine nucleosidase (uridine-cytidine N-ribohydrolase), cleaves N-glycosidic bonds in nucleosides; involved in the pyrimidine salvage and nicotinamide riboside salvage pathways pyrimidine-containing compound salvage|NAD biosynthesis via nicotinamide riboside salvage pathway|pyrimidine nucleoside catabolic process|nicotinate nucleotide salvage ribosylpyrimidine nucleosidase activity|nicotinic acid riboside hydrolase activity|nicotinamide riboside hydrolase activity|uridine nucleosidase activity nucleus|cytoplasm
YER186C_p YER186C YER186C hom Uncharacterized 0.253042583281393 0.400117653508613 no 1923 0.392973627741163 1308 NA Putative protein of unknown function biological_process molecular_function cellular_component
YIL041W YIL041W GVP36 hom Verified 0.252751304172498 0.400230199840517 no 1924 0.411349583630309 1362 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION ENDOMEMBRANE SYSTEM|GOLGI APPARATUS BAR domain-containing protein that localizes to both early and late Golgi vesicles; required for adaptation to varying nutrient concentrations, fluid-phase endocytosis, polarization of the actin cytoskeleton, and vacuole biogenesis vacuole organization|endocytosis|establishment or maintenance of actin cytoskeleton polarity molecular_function integral to Golgi membrane|cytoplasm
YLR431C YLR431C ATG23 hom Verified 0.252086073967004 0.40048726690616 no 1925 0.408885457770865 1350 NA FT PROTEIN LOCALIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Peripheral membrane protein required for the cytoplasm-to-vacuole targeting (Cvt) pathway and efficient macroautophagy; cycles between the phagophore assembly site (PAS) and non-PAS locations; forms a complex with Atg9p and Atg27p protein localization to pre-autophagosomal structure|positive regulation of macroautophagy|CVT pathway molecular_function pre-autophagosomal structure|extrinsic to membrane
YGL115W YGL115W SNF4 hom Verified 0.251952839789138 0.400538758207045 no 1926 0.39426894623016 1284 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|PLASMA MEMBRANE Activating gamma subunit of the AMP-activated Snf1p kinase complex; additional subunits of the complex are Snf1p and a Sip1p/Sip2p/Gal83p family member; activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis; protein abundance increases in response to DNA replication stress positive regulation of gluconeogenesis|peroxisome organization|protein phosphorylation|replicative cell aging|regulation of transcription from RNA polymerase II promoter AMP-activated protein kinase activity|protein serine/threonine kinase activator activity AMP-activated protein kinase complex|plasma membrane|nucleus|nuclear envelope lumen|cytoplasm
YLR046C_p YLR046C YLR046C hom Uncharacterized 0.251396013637183 0.400753974712249 no 1927 0.384889091557975 1276 NA Putative membrane protein; member of the fungal lipid-translocating exporter (LTE) family of proteins; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance biological_process molecular_function integral to membrane
YNL332W YNL332W THI12 hom Verified 0.251111628698674 0.400863902751162 no 1928 0.384775180023323 1263 NA Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13 thiamine biosynthetic process molecular_function cellular_component
YHR045W_p YHR045W YHR045W hom Uncharacterized 0.250624132976207 0.401052360837152 no 1929 0.398947182343467 1301 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS ENDOPLASMIC RETICULUM Putative protein of unknown function; possible role in iron metabolism and/or amino acid and carbohydrate metabolism; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum biological_process molecular_function endoplasmic reticulum
YKR035W-A YKR035W-A DID2 hom Verified 0.250166431145941 0.401229322038382 no 1930 0.400234061719843 1317 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM Class E protein of the vacuolar protein-sorting (Vps) pathway; binds Vps4p and directs it to dissociate ESCRT-III complexes; forms a functional and physical complex with Ist1p; human ortholog may be altered in breast tumors late endosome to vacuole transport via multivesicular body sorting pathway|late endosome to vacuole transport|protein targeting to vacuole molecular_function late endosome|cytoplasm
YOR350C YOR350C MNE1 hom Verified 0.249849568231181 0.401351842579401 no 1931 0.406553467143004 1341 NA FT RNA PROCESSING MITOCHONDRION Mitochondrial matrix protein involved in splicing Group I aI5-beta intron from COX1 mRNA Group I intron splicing molecular_function mitochondrion|ribonucleoprotein complex|mitochondrial matrix
YCL012C YCL012C YCL012C hom Verified 0.249701005769644 0.401409290172346 no 1932 0.388442043696395 1274 NA Putative protein of unknown function; orthologs are present in S. bayanus, S. paradoxus and Ashbya gossypii; YCL012C is not an essential gene biological_process molecular_function cellular_component
YAL023C YAL023C PMT2 hom Verified 0.24946604713507 0.40150015063678 no 1933 0.421455865321108 1380 NA FT PROTEIN LOCALIZATION|CARBOHYDRATE METABOLISM|PROTEOLYSIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein O-mannosyltransferase of the ER membrane; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; involved in ER quality control; acts in a complex with Pmt1p, can instead interact with Pmt5p; antifungal drug target; PMT2 has a paralog, PMT3, that arose from the whole genome duplication ER-associated misfolded protein catabolic process|protein O-linked glycosylation|Unknown|protein exit from endoplasmic reticulum|protein O-linked mannosylation dolichyl-phosphate-mannose-protein mannosyltransferase activity integral to membrane|dolichyl-phosphate-mannose-protein mannosyltransferase complex
YFL030W YFL030W AGX1 hom Verified 0.249457302982325 0.401503532176427 no 1934 0.401116322845087 1330 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases glycine biosynthetic process, by transamination of glyoxylate alanine-glyoxylate transaminase activity mitochondrion
YOL159C YOL159C YOL159C hom Verified 0.248958224819379 0.401696547952123 no 1935 0.390699708564782 1300 NA Soluble protein of unknown function; deletion mutants are viable and have elevated levels of Ty1 retrotransposition and Ty1 cDNA biological_process molecular_function cellular_component
YMR075C-A_d YMR075C-A YMR075C-A hom Dubious 0.248395412055831 0.401914241510431 no 1936 0.38755958257523 1288 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RCO1/YMR075W Unknown Unknown Unknown
YER135C_d YER135C YER135C hom Dubious 0.247487981870175 0.402265295674386 no 1937 0.397202011737602 1303 NA Dubious open reading frame unlikely to encode a protein; YER135C is not an essential gene Unknown Unknown Unknown
YHR132C YHR132C ECM14 hom Verified 0.247293479634441 0.402340552306658 no 1938 0.394983381005122 1319 NA FT CELL WALL ORG/BIOGENESIS|PROTEOLYSIS Putative metalloprotease with similarity to the zinc carboxypeptidase family, required for normal cell wall assembly fungal-type cell wall organization|proteolysis metalloendopeptidase activity fungal-type vacuole
YLR415C_p YLR415C YLR415C hom Uncharacterized 0.247027953526205 0.402443295275994 no 1939 0.403190151130012 1348 NA FT MITOCHONDRION Putative protein of unknown function; YLR415C is not an essential gene biological_process molecular_function cellular_component
YOR274W YOR274W MOD5 hom Verified 0.246722023582829 0.402561680505713 no 1940 0.403685481694565 1345 NA FT RNA PROCESSING NUCLEUS|MITOCHONDRION Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase; required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms; converts to a prion form, and prion conversion contributes to azole antifungal resistance by upregulating ergosterol biosynthesis tRNA modification tRNA dimethylallyltransferase activity cytosol|mitochondrion|nucleolus|nucleus
YLR427W YLR427W MAG2 hom Verified 0.246113306452514 0.402797261386432 no 1941 0.414464924312923 1388 NA Cytoplasmic protein of unknown function; induced in response to mycotoxin patulin; ubiquitinated protein similar to the human ring finger motif protein RNF10; predicted to be involved in repair of alkylated DNA due to interaction with MAG1 biological_process molecular_function cytoplasm
YBR245C YBR245C ISW1 hom Verified 0.245275562762988 0.40312153600847 no 1942 0.393832954690413 1302 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; ATPase; forms a complex with Ioc3p (Isw1a), and a complex with Ioc2p and Ioc4p (Isw1b); Isw1a and Isw1b have partially overlapping and distinct roles, Isw1a involved in repression of transcription initiation and Isw1b involved in regulation of transcription elongation; Isw1b recruited to open reading frames by H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions termination of RNA polymerase I transcription|nucleosome positioning|termination of RNA polymerase II transcription|regulation of transcription by chromatin organization|DNA-dependent transcription, elongation|regulation of transcriptional start site selection at RNA polymerase II promoter|heterochromatin maintenance involved in chromatin silencing|chromatin remodeling|positive regulation of transcription from RNA polymerase II promoter nucleosome binding|ATPase activity|rDNA binding|DNA binding ISW1 complex|nucleolar chromatin
YJL170C YJL170C ASG7 hom Verified 0.245191697345833 0.403154002386676 no 1943 0.408363634892174 1357 NA FT ENDOMEMBRANE SYSTEM|PLASMA MEMBRANE Protein that regulates signaling from a G protein beta subunit Ste4p and its relocalization within the cell; specific to a-cells and induced by alpha-factor conjugation with cellular fusion molecular_function plasma membrane
YJL212C YJL212C OPT1 hom Verified 0.244971960330118 0.403239071188448 no 1944 0.401544637837875 1363 NA FT PROTEIN LOCALIZATION PLASMA MEMBRANE Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family oligopeptide transport|sulfur compound metabolic process oligopeptide transporter activity|proton-dependent oligopeptide secondary active transmembrane transporter activity integral to membrane|integral to plasma membrane
YMR063W YMR063W RIM9 hom Verified 0.244024496190808 0.403605924043727 no 1945 0.415277462727177 1377 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Plasma membrane protein of unknown function; involved in the proteolytic activation of Rim101p in response to alkaline pH; interacts with Rim21p and Dfg16p to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; has similarity to A. nidulans PalI; ascospore formation molecular_function integral to membrane
YGL234W YGL234W ADE5,7 hom Verified 0.242826304448056 0.404069978666137 no 1946 0.403696709723462 1332 NA FT NUCLEOTIDE METABOLISM Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities purine nucleobase metabolic process|purine nucleotide biosynthetic process|'de novo' IMP biosynthetic process phosphoribosylamine-glycine ligase activity|phosphoribosylformylglycinamidine cyclo-ligase activity cytoplasm
YPR001W YPR001W CIT3 hom Verified 0.242143694413411 0.404334411080935 no 1947 0.415705998580919 1353 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate propionate catabolic process, 2-methylcitrate cycle|propionate metabolic process|tricarboxylic acid cycle 2-methylcitrate synthase activity|citrate (Si)-synthase activity mitochondrion
YDR070C YDR070C FMP16 hom Verified 0.241798712151767 0.404468068430299 no 1948 0.397973818052928 1317 NA FT MITOCHONDRION Protein of unknown function; may be involved in responding to conditions of stress; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress biological_process molecular_function mitochondrion
YMR019W YMR019W STB4 hom Verified 0.24119495360046 0.404702010954209 no 1949 0.40186870082527 1317 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Putative transcription factor; contains a Zn(II)2Cys6 zinc finger domain characteristic of DNA-binding proteins; computational analysis suggests a role in regulation of expression of genes encoding transporters; binds Sin3p in a two-hybrid assay; biological_process sequence-specific DNA binding|DNA binding nucleus
YER024W YER024W YAT2 hom Verified 0.240762494375343 0.404869599883495 no 1950 0.412092424776378 1355 NA FT KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane carnitine metabolic process|alcohol metabolic process carnitine O-acetyltransferase activity cytosol|cytoplasm
YPL111W YPL111W CAR1 hom Verified 0.240485374073932 0.404977000211697 no 1951 0.415433636477597 1375 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS|SITE OF POLARIZED GROWTH Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance regulation of ornithine metabolic process|arginine catabolic process to ornithine manganese ion binding|arginase activity|ornithine carbamoyltransferase inhibitor activity|zinc ion binding cytosol|nucleus|mating projection tip|cytoplasm
YNR068C_p YNR068C YNR068C hom Uncharacterized 0.239764858409406 0.405256275660666 no 1952 0.398655276862101 1301 NA Putative protein of unknown function; exhibits homology to C-terminal end of Bul1p; expressed as a readthrough product of BSC5, the readthrough locus being termed BUL3; the BUL3 readthrough product is involved in ubiquitin-mediated sorting of plasma membrane proteins and interacts with WW domains of Rsp5p in vitro, but in a functionally different way than the non-readthrough form biological_process molecular_function cellular_component
YHR210C_p YHR210C YHR210C hom Uncharacterized 0.238742351530562 0.405652687194049 no 1953 0.409115032508223 1352 NA FT CARBOHYDRATE METABOLISM Putative aldose 1-epimerase superfamily protein; non-essential gene; highly expressed under anaeorbic conditions biological_process molecular_function cellular_component
YGL045W YGL045W RIM8 hom Verified 0.238741926547119 0.4056528519743 no 1954 0.419840416331701 1373 NA FF|FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family meiosis|protein processing|invasive growth in response to glucose limitation|ubiquitin-dependent endocytosis molecular_function internal side of plasma membrane
YBR292C_d YBR292C YBR292C hom Dubious 0.238523682597313 0.405737474638591 no 1955 0.403013876754033 1350 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene Unknown Unknown Unknown
YBR161W YBR161W CSH1 hom Verified 0.238514721798849 0.405740949223771 no 1956 0.390565692250494 1316 NA FT LIPID METABOLISM Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Sur1p; CSH1 has a paralog, SUR1, that arose from the whole genome duplication glycosphingolipid biosynthetic process|sphingolipid biosynthetic process mannosyltransferase activity|transferase activity, transferring glycosyl groups integral to membrane|fungal-type vacuole
YMR216C YMR216C SKY1 hom Verified 0.238437998221621 0.405770699399415 no 1957 0.449839109314958 1466 NA FF|FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1 cellular cation homeostasis|cellular ion homeostasis|response to drug|protein phosphorylation|positive regulation of protein import into nucleus|regulation of cell size|mRNA splice site selection protein serine/threonine kinase activity|protein kinase activity cytoplasm
YHL023C YHL023C NPR3 hom Verified 0.23801043586436 0.405936500057774 no 1958 0.424058159836043 1414 NA FT CELL CYCLE|SIGNALING|RESPONSE TO NUTRIENT LEVELS Subunit of SEA (Seh1-associated), Npr2/3, and Iml1p complexes; Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation; SEA complex is a coatomer-related complex that associates dynamically with the vacuole; Iml1p complex (Iml1p-Npr2p-Npr3p) is required for non-nitrogen-starvation (NNS)-induced autophagy; required for Npr2p phosphorylation and Iml1p-Npr2p interaction; null mutant shows delayed meiotic DNA replication and double-strand break repair meiosis|regulation of TOR signaling cascade|cellular response to amino acid starvation molecular_function Seh1-associated complex|extrinsic to fungal-type vacuolar membrane
YJL046W YJL046W AIM22 hom Verified 0.237490292592542 0.406138224604081 no 1959 0.405892886741143 1337 NA FT MITOCHONDRION Putative lipoate-protein ligase, required along with Lip2 and Lip5 for lipoylation of Lat1p and Kgd2p; similar to E. coli LplA; null mutant displays reduced frequency of mitochondrial genome loss protein lipoylation lipoate-protein ligase activity mitochondrion
YNL277W-A_p YNL277W-A YNL277W-A hom Uncharacterized 0.237485860770685 0.406139943482382 no 1960 0.390863319806517 1319 NA Putative protein of unknown function biological_process molecular_function cellular_component
YGL094C YGL094C PAN2 hom Verified 0.237179250765484 0.406258866299941 no 1961 0.415201770523161 1400 NA FT RNA PROCESSING|RESPONSE TO DNA DAMAGE|PROTEOLYSIS Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes mRNA 3'-end processing|postreplication repair|mRNA processing poly(A)-specific ribonuclease activity PAN complex|cytoplasm
YGL254W YGL254W FZF1 hom Verified 0.23696552997072 0.406341765902811 no 1962 0.414341289446151 1363 NA FT TRANSCRIPTION FROM RNA POL II|ION HOMEOSTASIS|ION HOMEOSTASIS NUCLEUS Transcription factor involved in sulfite metabolism; sole identified regulatory target is SSU1; overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1, contains five zinc fingers; protein abundance increases in response to DNA replication stress positive regulation of sulfite transport by positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YER028C YER028C MIG3 hom Verified 0.23619714458443 0.406639847567442 no 1963 0.404330842066471 1356 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Transcriptional regulator; partially nonfunctional in S288C strains but has a major role in catabolite repression and ethanol response in some other strains; involved in response to toxic agents; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes; MIG3 has a paralog, MIG2, that arose from the whole genome duplication cellular response to UV|negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|response to DNA damage stimulus RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding nuclear chromatin
YGL056C YGL056C SDS23 hom Verified 0.236172552502006 0.406649388529871 no 1964 0.404974360051635 1364 NA FT CELL DIVISION NUCLEUS One of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; involved in cell separation during budding; SDS23 has a paralog, SDS24, that arose from the whole genome duplication cytokinetic cell separation molecular_function nucleus|cytoplasm
YPR091C YPR091C NVJ2 hom Verified 0.23616772151765 0.406651262807924 no 1965 0.396833569767803 1310 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments biological_process lipid binding ribosome|nucleus-vacuole junction|endoplasmic reticulum
YPL042C YPL042C SSN3 hom Verified 0.236043682471397 0.406699386995942 no 1966 0.419308581957169 1412 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS NUCLEUS Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression phosphorylation of RNA polymerase II C-terminal domain|negative regulation of transcription from RNA polymerase II promoter|negative regulation of filamentous growth|protein phosphorylation|protein destabilization|nuclear-transcribed mRNA catabolic process, non-stop decay|positive regulation of transcription from RNA polymerase II promoter by galactose RNA polymerase II carboxy-terminal domain kinase activity|protein kinase activity|cyclin-dependent protein kinase activity mediator complex
YLL063C YLL063C AYT1 hom Verified 0.234947320466317 0.407124810461949 no 1967 0.377482979511177 1266 NA Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis secondary metabolic process trichothecene 3-O-acetyltransferase activity cellular_component
YER092W YER092W IES5 hom Verified 0.234750325871072 0.407201262284621 no 1968 0.401696866869899 1290 NA FT NUCLEUS Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions biological_process molecular_function nucleus
YDR127W YDR127W ARO1 hom Verified 0.234437315780918 0.40732274594357 no 1969 0.458665573615151 1493 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids aromatic amino acid family biosynthetic process shikimate kinase activity|shikimate 3-dehydrogenase (NADP+) activity|3-phosphoshikimate 1-carboxyvinyltransferase activity|3-dehydroquinate dehydratase activity|3-dehydroquinate synthase activity cytoplasm
YLR014C YLR014C PPR1 hom Verified 0.233724904417616 0.407599276123758 no 1970 0.429077491888214 1399 NA FT TRANSCRIPTION FROM RNA POL II|NUCLEOTIDE METABOLISM NUCLEUS Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of URA1, URA3, URA4, and URA10, which are involved in de novo pyrimidine biosynthesis, in response to pyrimidine starvation; activity may be modulated by interaction with Tup1p positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding RNA polymerase II transcription factor activity|sequence-specific DNA binding|zinc ion binding nucleus
YLR169W_d YLR169W YLR169W hom Dubious 0.233717182393179 0.407602273763619 no 1971 0.391786251842978 1285 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YIR030C YIR030C DCG1 hom Verified 0.233555216961954 0.407665148941266 no 1972 0.404105509307325 1346 NA Protein of unknown function, expression is sensitive to nitrogen catabolite repression and regulated by Dal80p; contains transmembrane domain nitrogen compound metabolic process molecular_function cellular_component
YAL046C YAL046C AIM1 hom Verified 0.233278077110337 0.40777274048518 no 1973 0.412193552588312 1337 NA Protein involved in mitochondrial function or organization; null mutant displays elevated frequency of mitochondrial genome loss biological_process molecular_function cellular_component
YJL082W YJL082W IML2 hom Verified 0.232889289126947 0.407923687914253 no 1974 0.385350285788394 1267 NA FT NUCLEUS|MITOCHONDRION Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; IML2 has a paralog, YKR018C, that arose from the whole genome duplication biological_process molecular_function mitochondrial outer membrane|mitochondrion|nucleus|cytoplasm
YMR186W YMR186W HSC82 hom Verified 0.232645859094277 0.408018206893578 no 1975 0.411308488644217 1361 NA FT PROTEIN COMPLEX ORG/BIOGENESIS MITOCHONDRION Cytoplasmic chaperone of the Hsp90 family; redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock; contains two acid-rich unstructured regions that promote the solubility of chaperone-substrate complexes; HSC82 has a paralog, HSP82, that arose from the whole genome duplication protein folding|proteasome assembly|protein refolding|telomere maintenance|'de novo' protein folding|box C/D snoRNP assembly|response to stress unfolded protein binding|ATPase activity, coupled|ATPase activity mitochondrion|plasma membrane|cytoplasm
YLR254C YLR254C NDL1 hom Verified 0.232065471286702 0.408243581377081 no 1976 0.40652277055929 1342 NA FT CELL CYCLE|CELL DIVISION NUCLEUS|CYTOSKELETON Homolog of nuclear distribution factor NudE, NUDEL; interacts with Pac1p and regulates dynein targeting to microtubule plus ends nuclear migration along microtubule microtubule plus-end binding cytoplasmic microtubule|nucleus|cytoplasm
YBL058W YBL058W SHP1 hom Verified 0.231904329571696 0.408306160840508 no 1977 0.351533409687054 1163 NA FT PROTEIN LOCALIZATION|CELL CYCLE|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEOLYSIS|CYTOSKELETON ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY|CHROMOSOME SEGREGATION NUCLEUS UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p; interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate glycogen metabolic process|proteasomal ubiquitin-dependent protein catabolic process|piecemeal microautophagy of nucleus|ER-associated protein catabolic process|ascospore formation|sister chromatid biorientation|autophagic vacuole assembly protein phosphatase type 1 regulator activity nucleus|cytoplasm
YPR009W YPR009W SUT2 hom Verified 0.231699523104243 0.408385700906594 no 1978 0.418348475374298 1385 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1p positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter RNA polymerase II repressing transcription factor binding|sequence-specific DNA binding nucleus
YKL205W YKL205W LOS1 hom Verified 0.230723910929794 0.408764648206644 no 1979 0.420030631878557 1381 NA FT RNA PROCESSING|RNA LOCALIZATION NUCLEUS|MITOCHONDRION Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm tRNA re-export from nucleus|tRNA splicing, via endonucleolytic cleavage and ligation|tRNA export from nucleus tRNA binding|Ran GTPase binding mitochondrion|integral to membrane|nuclear matrix|cytoplasm
YBR255W YBR255W MTC4 hom Verified 0.230505237901217 0.408849596904352 no 1980 0.420183529257243 1383 NA Protein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; mtc4 is synthetically sick with cdc13-1 biological_process molecular_function cytoplasm
YJR151W-A_p YJR151W-A YJR151W-A hom Uncharacterized 0.23021566953308 0.408962093158279 no 1981 0.41117702312857 1338 NA Putative protein of unknown function; identified by fungal homology and RT-PCR; predicted to have a role in transcription based on computational guilt by association analysis biological_process molecular_function cellular_component
YPL140C YPL140C MKK2 hom Verified 0.230210693635273 0.408964026341981 no 1982 0.409345689578774 1344 NA FT SIGNALING|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1p; MKK2 has a paralog, MKK1, that arose from the whole genome duplication signal transduction|peroxisome degradation|protein phosphorylation MAP kinase kinase activity intracellular
YDR034W-B_p YDR034W-B YDR034W-B hom Uncharacterized 0.230097740689827 0.409007910232951 no 1983 0.418467267206034 1389 NA Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery biological_process molecular_function cellular_component
YNL311C YNL311C SKP2 hom Verified 0.229980444784974 0.40905348263511 no 1984 0.416508516922387 1353 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|PROTEOLYSIS UBIQUITIN LIGASE COMPLEX F-box protein of unknown function predicted to be part of an SCF ubiquitin protease complex; involved in regulating protein levels of sulfur metabolism enzymes; may interact with ribosomes, based on co-purification experiments SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular protein catabolic process|regulation of sulfur amino acid metabolic process ubiquitin-protein ligase activity|protein binding, bridging ribosome|SCF ubiquitin ligase complex
YGL025C YGL025C PGD1 hom Verified 0.228827151352089 0.409501631446718 no 1985 0.43797207137429 1463 NA FF|FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II repressing transcription factor binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription factor recruiting transcription factor activity core mediator complex
YMR018W_p YMR018W YMR018W hom Uncharacterized 0.228772520571491 0.409522862911206 no 1986 0.420856704445976 1378 NA FT PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION Putative protein of unknown function with similarity to human PEX5Rp (peroxin protein 5 related protein); transcription increases during colony development similar to genes involved in peroxisome biogenesis; YMR018W is not an essential gene biological_process molecular_function cellular_component
YDR524C-B_p YDR524C-B YDR524C-B hom Uncharacterized 0.227629532371765 0.409967129541443 no 1987 0.421226221143493 1431 NA FT PLASMA MEMBRANE Putative protein of unknown function; YDR524C-B has a paralog, YCL048W-A, that arose from the whole genome duplication biological_process molecular_function cellular_component
YJR052W YJR052W RAD7 hom Verified 0.227515060843471 0.410011629712008 no 1988 0.414161306273012 1368 NA FT RESPONSE TO DNA DAMAGE|PROTEOLYSIS NUCLEUS UBIQUITIN LIGASE COMPLEX Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex nucleotide-excision repair, DNA damage recognition|protein ubiquitination involved in ubiquitin-dependent protein catabolic process damaged DNA binding|ubiquitin-protein ligase activity|DNA-dependent ATPase activity nucleotide-excision repair factor 4 complex|Cul3-RING ubiquitin ligase complex
YDL142C YDL142C CRD1 hom Verified 0.226958235897063 0.41022810883616 no 1989 0.410073859363184 1347 NA FT LIPID METABOLISM|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS MITOCHONDRION Cardiolipin synthase; produces cardiolipin, which is a phospholipid of the mitochondrial inner membrane that is required for normal mitochondrial membrane potential and function; also required for normal vacuolar ion homeostasis lipid biosynthetic process|cellular ion homeostasis|mitochondrial membrane organization cardiolipin synthase activity mitochondrion|integral to membrane
YOR105W_p YOR105W YOR105W hom Uncharacterized 0.225618659445913 0.410749013442019 no 1990 0.400899713934746 1318 NA Protein of unknown function; expressed at both mRNA and protein levels biological_process molecular_function cellular_component
YPL096C-A YPL096C-A ERI1 hom Verified 0.22450069050992 0.411183864839047 no 1991 0.430062062803304 1432 NA FT LIPID METABOLISM|SIGNALING ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Endoplasmic reticulum membrane protein that binds to and inhibits GTP-bound Ras2p at the ER; component of the GPI-GnT complex which catalyzes the first step in GPI-anchor biosynthesis; probable homolog of mammalian PIG-Y protein GPI anchor biosynthetic process|Ras protein signal transduction GTPase inhibitor activity glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|endoplasmic reticulum membrane
YJR144W YJR144W MGM101 hom Verified 0.224060912824416 0.411354953149595 no 1992 0.420940788689036 1368 NA FT RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION MITOCHONDRION|CHROMOSOME Protein with a role in mitochondrial DNA recombinational repair;also involved in interstrand cross-link repair; binds to and catalyzes the annealing of single-stranded mtDNA; oligomerizes to form rings and filaments; related to Rad52-type recombination proteins, with limited overall similarity but sharing conserved functionally important residues; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage DNA repair|recombinational repair|DNA strand renaturation molecular_function mitochondrial nucleoid|mitochondrion
YOL015W YOL015W IRC10 hom Verified 0.223772646663574 0.411467107530637 no 1993 0.418189209039755 1404 NA Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci biological_process molecular_function cellular_component
YLR398C YLR398C SKI2 hom Verified 0.22360957414695 0.411530556604545 no 1994 0.411603585139544 1381 NA FT TRANSLATION Ski complex component and putative RNA helicase, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, non-stop decay RNA helicase activity Ski complex
YDR523C YDR523C SPS1 hom Verified 0.22338245293497 0.411618929921455 no 1995 0.390867014336468 1295 NA FT CELL CYCLE|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION NUCLEUS Putative protein serine/threonine kinase expressed at the end of meiosis and localized to the prospore membrane, required for correct localization of enzymes involved in spore wall synthesis ascospore wall assembly|ascospore formation|protein phosphorylation protein serine/threonine kinase activity|protein kinase activity nucleus|prospore membrane|cytoplasm
YER088C YER088C DOT6 hom Verified 0.221759798514156 0.412250438185566 no 1996 0.426217997576596 1417 NA FT TRANSCRIPTION FROM RNA POL II|GENE SILENCING NUCLEUS|CHROMOSOME Protein involved in rRNA and ribosome biogenesis; binds polymerase A and C motif; subunit of the RPD3L histone deacetylase complex; has chromatin specific SANT domain; involved in telomeric gene silencing and filamentation; DOT6 has a paralog, TOD6, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress chromatin silencing at rDNA|filamentous growth|regulation of transcription from RNA polymerase II promoter|unidimensional cell growth|chromatin silencing at telomere sequence-specific DNA binding Rpd3L-Expanded complex|nucleus|Rpd3L complex|cytoplasm
YLR211C_p YLR211C YLR211C hom Uncharacterized 0.221544449760597 0.412334265211142 no 1997 0.40723271543277 1353 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR211C is not an essential gene; ORF contains an intron biological_process molecular_function cytoplasm
YGR204C-A_p YGR204C-A YGR204C-A hom Uncharacterized 0.221093290997985 0.412509897007703 no 1998 0.40892830868286 1359 NA Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YGR161C_p YGR161C RTS3 hom Uncharacterized 0.221000532682049 0.412546009106467 no 1999 0.41205418111238 1348 NA FT NUCLEUS Putative component of the protein phosphatase type 2A complex biological_process molecular_function nucleus|cytoplasm
YER001W YER001W MNN1 hom Verified 0.220347502366653 0.412800263799192 no 2000 0.402534940591461 1317 NA FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family N-glycan processing|protein O-linked glycosylation alpha-1,3-mannosyltransferase activity Golgi apparatus
YCR090C_p YCR090C YCR090C hom Uncharacterized 0.21931029033023 0.413204173245739 no 2001 0.368634260348212 1239 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YCR090C is not an essential gene biological_process molecular_function nucleus|cytoplasm
YPL150W_p YPL150W YPL150W hom Uncharacterized 0.218890869663668 0.413367529483123 no 2002 0.401122015360564 1323 NA FT PROTEIN PHOSPHORYLATION Protein kinase of unknown cellular role; binds phosphatidylinositols and cardiolipin in a large-scale study protein phosphorylation protein kinase activity cellular_component
YGR004W YGR004W PEX31 hom Verified 0.218680865848448 0.41344932754381 no 2003 0.381991597721194 1252 NA FT PEROXISOME ORGANIZATION Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex30p and Pex32p; probably acts at a step downstream of steps mediated by Pex28p and Pex29p peroxisome organization molecular_function integral to membrane|integral to peroxisomal membrane
YGR148C YGR148C RPL24B hom Verified 0.218414701839099 0.413553005818563 no 2004 0.407363173381003 1323 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L24B; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24B has a paralog, RPL24A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YLL017W YLL017W YLL017W hom pseudogene 0.218320487956739 0.413589706187399 no 2005 0.384196265683644 1261 NA FT SIGNALING Non-essential Ras guanine nucleotide exchange factor (GEF); localized to the membrane; expressed in poor nutrient conditions and on nonfermentable carbon sources; contains a stop codon in S288C, full-length gene includes YLL016W; SDC25 has a paralog, CDC25, that arose from the whole genome duplication Ras protein signal transduction Ras guanyl-nucleotide exchange factor activity membrane
YML026C YML026C RPS18B hom Verified 0.218233531625917 0.413623580096942 no 2006 0.39623857850846 1301 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION MITOCHONDRION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18B has a paralog, RPS18A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress cytoplasmic translation|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA export from nucleus structural constituent of ribosome cytosolic small ribosomal subunit|mitochondrion
YNL125C YNL125C ESBP6 hom Verified 0.217193894198908 0.414028621421146 no 2007 0.412541501000069 1338 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane transport monocarboxylic acid transmembrane transporter activity|transporter activity mitochondrion|integral to membrane|endoplasmic reticulum|membrane
YDL112W YDL112W TRM3 hom Verified 0.217153156592555 0.414044494602082 no 2008 0.430176225384479 1436 NA FT RNA PROCESSING 2'-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs tRNA methylation tRNA (guanine) methyltransferase activity cytoplasm
YHR049C-A_d YHR049C-A YHR049C-A hom Dubious 0.215507471685656 0.414685843678797 no 2009 0.401145883887433 1316 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YKL129C YKL129C MYO3 hom Verified 0.215409957441036 0.414723853656773 no 2010 0.391597771833027 1294 NA FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION CYTOSKELETON One of two type I myosins; localizes to actin cortical patches; deletion of MYO3 has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization bipolar cellular bud site selection|fungal-type cell wall organization|endocytosis|exocytosis|actin cortical patch localization|response to osmotic stress microfilament motor activity actin cortical patch
YPR083W YPR083W MDM36 hom Verified 0.215299841634968 0.414766776544382 no 2011 0.424833837117969 1387 NA FT MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial protein required for normal mitochondrial morphology and inheritance; proposed involvement in the formation of Dnm1p and Num1p-containing cortical anchor complexes that promote mitochondrial fission mitochondrial fission|mitochondrion organization molecular_function mitochondrion|cytoplasm
YOR377W YOR377W ATF1 hom Verified 0.215074295179522 0.414854697209592 no 2012 0.403595918026327 1310 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY ENDOMEMBRANE SYSTEM Alcohol acetyltransferase; responsible for the major part of volatile acetate ester production during fermentation; main enzyme involved in terpenyl acetate synthesis; potential roles in lipid and sterol metabolism Unknown|fermentation alcohol O-acetyltransferase activity lipid particle
YOR042W YOR042W CUE5 hom Verified 0.214903714506671 0.414921194398114 no 2013 0.413461790544099 1370 NA Protein containing a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern biological_process ubiquitin binding cytoplasm
YOR214C_p YOR214C YOR214C hom Uncharacterized 0.214025430398121 0.415263613022711 no 2014 0.420238265202634 1400 NA Putative protein of unknown function; YOR214C is not an essential gene biological_process molecular_function fungal-type cell wall
YOR364W_d YOR364W YOR364W hom Dubious 0.213216447211815 0.415579070098568 no 2015 0.403409325524412 1315 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C Unknown Unknown Unknown
YBL100W-C_p YBL100W-C YBL100W-C hom Uncharacterized 0.213085011567848 0.415630327610508 no 2016 0.415483080372312 1396 NA Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YDR514C YDR514C YDR514C hom Verified 0.212605416532628 0.415817373126125 no 2017 0.410469313738269 1341 NA FT NUCLEUS|MITOCHONDRION Protein of unknown function that localizes to mitochondria; overexpression affects endocytic protein trafficking; YDR514C has a paralog, GFD2, that arose from the whole genome duplication biological_process molecular_function mitochondrion|nucleus
YMR291W YMR291W TDA1 hom Verified 0.212019401720775 0.416045949007284 no 2018 0.397834149582308 1316 NA FT PROTEIN PHOSPHORYLATION NUCLEUS Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; relocalizes from nucleus to cytoplasm upon DNA replication stress protein phosphorylation protein kinase activity nucleus|cytoplasm
YJL204C YJL204C RCY1 hom Verified 0.211918051078494 0.416085483847188 no 2019 0.432492636749882 1420 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION GOLGI APPARATUS|SITE OF POLARIZED GROWTH F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth early endosome to Golgi transport|endocytosis SNARE binding endosome|Golgi apparatus|site of polarized growth
YMR242C YMR242C RPL20A hom Verified 0.211410457189428 0.416283498746159 no 2020 0.394584545124245 1317 NA FF|FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L20A; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20A has a paralog, RPL20B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YKL056C YKL056C TMA19 hom Verified 0.21065739260065 0.416577312120574 no 2021 0.405285140298011 1334 NA FT TRANSLATION|RESPONSE TO OXIDATIVE STRESS MITOCHONDRION|CYTOSKELETON Protein that associates with ribosomes; homolog of translationally controlled tumor protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and relocates to the mitochondrial outer surface upon oxidative stress cytoplasmic translation|cellular response to oxidative stress molecular_function cytosol|mitochondrion|ribosome|cytoplasm
YBR150C YBR150C TBS1 hom Verified 0.210250299654801 0.416736161678393 no 2022 0.408460814771172 1371 NA FT TRANSCRIPTION FROM RNA POL II ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; TBS1 has a paralog, HAL9, that arose from the whole genome duplication biological_process sequence-specific DNA binding mitochondrion|nucleus|cytoplasm
YKL124W YKL124W SSH4 hom Verified 0.210131203865112 0.416782635980401 no 2023 0.385798769586619 1299 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT Specificity factor required for Rsp5p-dependent ubiquitination and sorting of cargo proteins at the multivesicular body; identified as a high-copy suppressor of a SHR3 deletion, increasing steady-state levels of amino acid permeases protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|vesicle-mediated transport molecular_function fungal-type vacuole
YBR134W_d YBR134W YBR134W hom Dubious 0.209645596626148 0.416972144699401 no 2024 0.414180809129778 1362 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOR107W YOR107W RGS2 hom Verified 0.209544785859542 0.417011488623479 no 2025 0.427489467872745 1437 NA FT SIGNALING NUCLEUS|PLASMA MEMBRANE Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p adenylate cyclase-modulating G-protein coupled receptor signaling pathway GTPase activator activity nucleus|cytoplasm
YGL263W YGL263W COS12 hom Verified 0.209531750215881 0.417016576170278 no 2026 0.406984760638694 1343 NA Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins biological_process molecular_function integral to membrane
YMR284W YMR284W YKU70 hom Verified 0.209381362284969 0.417075270528088 no 2027 0.399311190296274 1319 NA FT CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair chromatin assembly or disassembly|chromatin silencing|double-strand break repair via nonhomologous end joining|telomere maintenance|double-strand break repair via break-induced replication|double-strand break repair via homologous recombination|chromatin silencing at silent mating-type cassette damaged DNA binding|RNA binding nuclear chromatin|nuclear telomeric heterochromatin|nuclear envelope|Ku70:Ku80 complex
YNL211C_p YNL211C YNL211C hom Uncharacterized 0.208776032405133 0.417311541200947 no 2028 0.417241628031699 1396 NA FT MITOCHONDRION Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL211C is not an essential gene biological_process molecular_function mitochondrion
YGR200C YGR200C ELP2 hom Verified 0.208584914407365 0.417386144051825 no 2029 0.423845609678781 1407 NA FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin regulation of transcription from RNA polymerase II promoter|protein urmylation|tRNA wobble uridine modification molecular_function Elongator holoenzyme complex|nucleus|cytoplasm
YGL066W YGL066W SGF73 hom Verified 0.208089333858416 0.417579607612898 no 2030 0.438134305950765 1444 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|RNA LOCALIZATION NUCLEUS HISTONE ACETYLTRANSFERASE SAGA complex subunit; has a role in anchoring the deubiquitination module into SAGA and SLIK complexes; involved in preinitiation complex assembly at promoters; human ortholog ataxin-7 is associated with spinocerebellar ataxia diseases; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay histone deubiquitination|mRNA export from nucleus|histone acetylation|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|protein complex assembly|chromatin modification histone acetyltransferase activity|enzyme activator activity|structural molecule activity DUBm complex|SLIK (SAGA-like) complex|SAGA complex
YDR493W YDR493W MZM1 hom Verified 0.206595078127148 0.418163052214587 no 2031 0.402636628385302 1320 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Protein required for assembly of the cytochrome bc(1) complex; acts as a chaperone for Rip1p and facilitates its insertion into the complex at a late stage of assembly; localized to the mitochondrial matrix; null mutant exhibits a respiratory growth defect and reduced mitochondrial zinc levels, which is characteristic of mutations affecting bc(1) complex assembly; human LYRM7 is a functional ortholog mitochondrial respiratory chain complex III assembly molecular_function mitochondrion|mitochondrial matrix
YPL077C_p YPL077C YPL077C hom Uncharacterized 0.205902612712799 0.418433492264879 no 2032 0.420427421106473 1381 NA Putative protein of unknown function; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene; YPL077C has a paralog, YBR197C, that arose from the whole genome duplication biological_process molecular_function cellular_component
YOR293W YOR293W RPS10A hom Verified 0.205449612405282 0.418610430891695 no 2033 0.366502716707625 1210 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication cytoplasmic translation|rRNA export from nucleus structural constituent of ribosome cytosolic small ribosomal subunit
YGL175C YGL175C SAE2 hom Verified 0.205250673426551 0.418688140216674 no 2034 0.400173321818945 1304 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS Endonuclease that processes hairpin DNA structures with the MRX complex; involved in meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents DNA double-strand break processing|DNA catabolic process, endonucleolytic|meiotic DNA double-strand break formation|meiotic DNA double-strand break processing|gene conversion at mating-type locus, DNA double-strand break processing double-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity nucleus|cytoplasm
YML011C YML011C RAD33 hom Verified 0.205197965814213 0.41870872933805 no 2035 0.407356067253639 1340 NA FT RESPONSE TO DNA DAMAGE NUCLEUS Protein involved in nucleotide excision repair; green fluorescent protein (GFP)-fusion protein localizes to the nucleus nucleotide-excision repair molecular_function nucleus
YKL206C YKL206C ADD66 hom Verified 0.204214132977279 0.419093083777506 no 2036 0.41765820140703 1382 NA FT PROTEIN COMPLEX ORG/BIOGENESIS Protein involved in 20S proteasome assembly; forms a heterodimer with Pba1p that binds to proteasome precursors; similar to human PAC2 constituent of the PAC1-PAC2 complex involved in proteasome assembly proteasome assembly molecular_function cytosol|cytoplasm
YOL004W YOL004W SIN3 hom Verified 0.203856137383177 0.41923296126817 no 2037 0.422828538792421 1375 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CELL DIVISION|GENE SILENCING NUCLEUS|CHROMOSOME Component of the Sin3p-Rpd3p histone deacetylase complex, involved in transcriptional repression and activation of diverse processes, including mating-type switching and meiosis; involved in the maintenance of chromosomal integrity positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of chromatin silencing at rDNA|histone deacetylation|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of transcription from RNA polymerase I promoter|negative regulation of transcription during meiosis|regulation of DNA-dependent DNA replication initiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of chromatin silencing at telomere|double-strand break repair via nonhomologous end joining|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription involved in G2/M-phase of mitotic cell cycle transcription coactivator activity|transcription corepressor activity Sin3-type complex|Rpd3S complex|Rpd3L-Expanded complex|Rpd3L complex
YNR012W YNR012W URK1 hom Verified 0.202952437569403 0.419586103896973 no 2038 0.433063322761242 1437 NA FT NUCLEOTIDE METABOLISM NUCLEUS Uridine/cytidine kinase, component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP; involved in the pyrimidine deoxyribonucleotide salvage pathway, converting deoxycytidine into dCMP pyrimidine-containing compound salvage uridine kinase activity nucleus|cytoplasm
YMR242W-A_p YMR242W-A YMR242W-A hom Uncharacterized 0.20136958381038 0.420204798328979 no 2039 0.410182104302004 1351 NA Putative protein of unknown function biological_process molecular_function cellular_component
YDR420W YDR420W HKR1 hom Verified 0.201307935072861 0.420228899141869 no 2040 0.424891699086201 1422 NA FT CELL CYCLE|SIGNALING|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Mucin family member that functions as an osmosensor in the Sho1p-mediated HOG pathway with Msb2p; proposed to be a negative regulator of filamentous growth; mutant displays defects in beta-1,3 glucan synthesis and bud site selection (1->3)-beta-D-glucan biosynthetic process|fungal-type cell wall organization|osmosensory signaling pathway via Sho1 osmosensor|hyperosmotic response|cellular bud site selection osmosensor activity site of polarized growth|plasma membrane
YNL034W_p YNL034W YNL034W hom Uncharacterized 0.201269798913245 0.420243808152434 no 2041 0.422875560766626 1375 NA Putative protein of unknown function; YNL034W is not an essential gene biological_process molecular_function cellular_component
YBR120C YBR120C CBP6 hom Verified 0.200641888984163 0.420489300691641 no 2042 0.418631464119192 1371 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex positive regulation of mitochondrial translation|mitochondrial respiratory chain complex III assembly ribosome binding mitochondrion|mitochondrial ribosome
YOR092W YOR092W ECM3 hom Verified 0.20062393691582 0.420496319826845 no 2043 0.425226022270656 1390 NA FT CELL WALL ORG/BIOGENESIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from ER to cytoplasm upon DNA replication stress; ECM3 has a paralog, YNL095C, that arose from the whole genome duplication fungal-type cell wall organization ATPase activity integral to membrane|endoplasmic reticulum
YBR195C YBR195C MSI1 hom Verified 0.200252055264496 0.420641728676606 no 2044 0.41918074035678 1382 NA FT CHROMATIN ORGANIZATION NUCLEUS Subunit of chromatin assembly factor I (CAF-1); chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription; Msi1p localizes to both nucleus and cytoplasm and has an independent role as a negative regulator of the RAS/cAMP pathway via sequestration of Npr1p kinase DNA replication-dependent nucleosome assembly histone binding nucleus|CAF-1 complex|cytoplasm
YLL062C YLL062C MHT1 hom Verified 0.200065612946785 0.42071463326579 no 2045 0.422115933752338 1400 NA FT KETONE METABOLISM|AMINO ACID METABOLISM S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio sulfur amino acid metabolic process homocysteine S-methyltransferase activity cytoplasm
YLR377C YLR377C FBP1 hom Verified 0.199949330119667 0.420760104747796 no 2046 0.422027542669709 1403 NA FT CARBOHYDRATE METABOLISM Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism; undergoes either proteasome-mediated or autophagy-mediated degradation depending on growth conditions; interacts with Vid30p gluconeogenesis|reactive oxygen species metabolic process fructose 1,6-bisphosphate 1-phosphatase activity cytosol
YLR423C YLR423C ATG17 hom Verified 0.199576887383826 0.420905752654055 no 2047 0.433100973687376 1422 NA FT MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION Scaffold protein responsible for phagophore assembly site organization; regulatory subunit of an autophagy-specific complex that includes Atg1p and Atg13p; stimulates Atg1p kinase activity; human ortholog RB1CC1/FIP200 interacts with p53, which inhibits autophagy in human cells piecemeal microautophagy of nucleus|mitochondrion degradation|peroxisome degradation|activation of protein kinase activity|autophagic vacuole assembly protein kinase activator activity|protein complex scaffold pre-autophagosomal structure|Atg1p signaling complex
YAR028W_p YAR028W YAR028W hom Uncharacterized 0.199350227976506 0.420994395656234 no 2048 0.427356043637696 1406 NA Putative integral membrane protein, member of DUP240 gene family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS biological_process molecular_function cellular_component
YKL057C YKL057C NUP120 hom Verified 0.199253429342395 0.42103225333151 no 2049 0.436802568524324 1447 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP160 double-strand break repair|protein export from nucleus|ribosomal large subunit export from nucleus|maintenance of chromatin silencing at telomere|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|telomere tethering at nuclear periphery|nuclear pore distribution|mRNA export from nucleus in response to heat stress|mRNA export from nucleus|positive regulation of transcription, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter structural constituent of nuclear pore integral to membrane|nuclear pore|nuclear pore outer ring
YNL074C YNL074C MLF3 hom Verified 0.19865302688731 0.421267085350965 no 2050 0.422725871813017 1394 NA Serine-rich protein of unknown function, predicted to be palmitoylated; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide response to drug molecular_function cytoplasm
YDR323C YDR323C PEP7 hom Verified 0.19864326453292 0.421270903877116 no 2051 0.438760418242862 1421 NA FF|FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance Golgi to vacuole transport|vacuole inheritance|vesicle fusion|vesicle docking involved in exocytosis|Golgi to endosome transport phosphatidylinositol-3-phosphate binding external side of endosome membrane|cytoplasm
YBR162C YBR162C TOS1 hom Verified 0.198380327978413 0.42137375378936 no 2052 0.386106053128426 1270 NA Covalently-bound cell wall protein of unknown function; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C biological_process molecular_function fungal-type cell wall|fungal-type vacuole
YJR104C YJR104C SOD1 hom Verified 0.198204247564162 0.421442632169293 no 2053 0.471825164763717 1573 NA FF|FT ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS NUCLEUS|MITOCHONDRION Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid cellular copper ion homeostasis|fungal-type cell wall organization|superoxide metabolic process|cellular zinc ion homeostasis|positive regulation of sequence-specific DNA binding transcription factor activity|age-dependent response to reactive oxygen species involved in chronological cell aging superoxide dismutase activity cytosol|mitochondrion|nucleus|mitochondrial intermembrane space
YMR191W YMR191W SPG5 hom Verified 0.197912211982053 0.421556874692309 no 2054 0.427628026803477 1390 NA Protein required for proteasome assembly during quiescence; binds to base of the proteasome regulartory particle; required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources biological_process molecular_function cellular_component
YLR390W YLR390W ECM19 hom Verified 0.197731907104983 0.421627412148447 no 2055 0.434768716537828 1449 NA FT CELL WALL ORG/BIOGENESIS MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies fungal-type cell wall organization molecular_function mitochondrion
YKL018C-A_p YKL018C-A YKL018C-A hom Uncharacterized 0.196832368142018 0.421979360234593 no 2056 0.412665094354703 1378 NA Putative protein of unknown function; identified by homology; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm biological_process molecular_function cytoplasm
YPL116W YPL116W HOS3 hom Verified 0.196369352853045 0.422160541062926 no 2057 0.415557148862776 1374 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION NUCLEUS|SITE OF POLARIZED GROWTH Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) with specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats regulation of transcription involved in G1/S phase of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|histone deacetylation histone deacetylase activity nucleus|cellular bud neck|cytoplasm
YOR172W YOR172W YRM1 hom Verified 0.196242460316594 0.4222101977974 no 2058 0.423263749126185 1399 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrr1p, acting on an overlapping set of target genes regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding|nucleic acid binding transcription factor activity nucleus|cytoplasm
YML041C YML041C VPS71 hom Verified 0.195986178053679 0.422310492259257 no 2059 0.420432973184804 1399 NA FF|FT PROTEIN LOCALIZATION|CHROMATIN ORGANIZATION|VACUOLAR TRANSPORT NUCLEUS|CHROMOSOME Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting chromatin remodeling|protein targeting to vacuole|histone exchange nucleosome binding Swr1 complex|nucleus
YOR301W YOR301W RAX1 hom Verified 0.195772118814337 0.422394266866103 no 2060 0.408551316180428 1331 NA FT CELL CYCLE|SIGNALING|CELL DIVISION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily cellular bud site selection molecular_function integral to membrane|cellular bud neck
YBL008W-A_p YBL008W-A YBL008W-A hom Uncharacterized 0.195549822667137 0.422481268799935 no 2061 0.417580126228515 1367 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YML058W-A YML058W-A HUG1 hom Verified 0.194699345298457 0.422814162239752 no 2062 0.419829698993717 1387 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS Protein involved in the Mec1p-mediated checkpoint pathway; transcription is induced by DNA damage; protein abundance increases in response to DNA replication stress cell cycle arrest|cell cycle checkpoint|response to DNA damage stimulus molecular_function cytoplasm
YKL033W-A_p YKL033W-A YKL033W-A hom Uncharacterized 0.194131852546126 0.423036320657175 no 2063 0.465769664758917 1564 NA Putative protein of unknown function; similar to uncharacterized proteins from other fungi biological_process molecular_function cellular_component
YDL213C YDL213C NOP6 hom Verified 0.193699940621864 0.423205419169841 no 2064 0.423480905375928 1395 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS rRNA-binding protein required for 40S ribosomal subunit biogenesis; contains an RNA recognition motif (RRM); hydrophilin essential to overcome the stress of the desiccation-rehydration process; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes ribosomal small subunit biogenesis RNA binding|rRNA binding nucleolus|90S preribosome
YDR183W YDR183W PLP1 hom Verified 0.193184765761757 0.423407134583619 no 2065 0.405878774171943 1314 NA FT TRANSCRIPTION FROM RNA POL II|SIGNALING Protein that interacts with CCT (chaperonin containing TCP-1) complex and has a role in actin and tubulin folding; has weak similarity to phosducins, which are G-protein regulators protein folding|positive regulation of transcription from RNA polymerase II promoter by pheromones G-protein beta/gamma-subunit complex binding cellular_component
YBR147W YBR147W RTC2 hom Verified 0.192624586701691 0.423626494060243 no 2066 0.418030050271871 1380 NA FT MITOCHONDRION Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; positive regulation by Lys14p suggests that lysine may be the primary substrate; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter biological_process molecular_function mitochondrion|integral to membrane
YNL220W YNL220W ADE12 hom Verified 0.192576433292685 0.423645351469939 no 2067 0.424551445643988 1406 NA FT NUCLEOTIDE METABOLISM Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence purine nucleotide biosynthetic process DNA replication origin binding|adenylosuccinate synthase activity cytoplasm
YGR199W YGR199W PMT6 hom Verified 0.192544667545058 0.423657791385189 no 2068 0.433485192232339 1434 NA FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein O-mannosyltransferase, transfers mannose from dolichyl phosphate-D-mannose to protein serine/threonine residues of secretory proteins; reaction is essential for cell wall rigidity; member of a family of mannosyltransferases protein O-linked glycosylation|protein O-linked mannosylation dolichyl-phosphate-mannose-protein mannosyltransferase activity integral to membrane
YOR024W_d YOR024W YOR024W hom Dubious 0.192200973031108 0.423792391871882 no 2069 0.430294979698912 1412 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR079W YDR079W PET100 hom Verified 0.192101672945668 0.423831282248504 no 2070 0.419949153801991 1389 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme mitochondrial respiratory chain complex IV assembly|aerobic respiration unfolded protein binding mitochondrion|mitochondrial inner membrane|integral to mitochondrial inner membrane
YHR203C YHR203C RPS4B hom Verified 0.191305219186557 0.424143236144698 no 2071 0.438791692827586 1452 NA FT TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4B has a paralog, RPS4A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic small ribosomal subunit|90S preribosome
YLR421C YLR421C RPN13 hom Verified 0.191142648628037 0.424206917401852 no 2072 0.430110192465238 1431 NA FT PROTEOLYSIS NUCLEUS Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; protein abundance increases in response to DNA replication stress ubiquitin-dependent protein catabolic process ubiquitin binding proteasome storage granule|proteasome regulatory particle, lid subcomplex
YDR244W YDR244W PEX5 hom Verified 0.190605429213581 0.424417368141524 no 2073 0.432956442875199 1442 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PEROXISOME ORGANIZATION Peroxisomal membrane signal receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions protein import into peroxisome matrix, docking peroxisome matrix targeting signal-1 binding|protein binding, bridging cytosol|peroxisomal membrane|peroxisome
YDR379C-A YDR379C-A YDR379C-A hom Verified 0.190586487983989 0.424424788586782 no 2074 0.421604394417184 1395 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; mutations in human ortholog SDHAF1 are associated with infantile leukoencephalopathy mitochondrial respiratory chain complex II assembly molecular_function mitochondrion
YGR168C_p YGR168C YGR168C hom Uncharacterized 0.190355052280176 0.424515458356796 no 2075 0.442551770295375 1465 NA Putative protein of unknown function; YGR168C is not an essential gene biological_process molecular_function integral to membrane
YGR242W_d YGR242W YGR242W hom Dubious 0.190070273758715 0.42462703177076 no 2076 0.426119306208775 1389 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C Unknown Unknown Unknown
YOR280C YOR280C FSH3 hom Verified 0.189927046272631 0.424683149169286 no 2077 0.424187954883446 1396 NA Putative serine hydrolase; likely target of Cyc8p-Tup1p-Rfx1p transcriptional regulation; sequence is similar to S. cerevisiae Fsh1p and Fsh2p and the human candidate tumor suppressor OVCA2 biological_process molecular_function cellular_component
YCL063W YCL063W VAC17 hom Verified 0.188767043047216 0.425137701627106 no 2078 0.416089624269172 1360 NA Phosphoprotein involved in vacuole inheritance; degraded in late M phase of the cell cycle; acts as a vacuole-specific receptor for myosin Myo2p vacuole inheritance protein anchor fungal-type vacuole membrane
YGL215W YGL215W CLG1 hom Verified 0.187827371552484 0.425505989115878 no 2079 0.436949450826181 1417 NA FT CELL CYCLE|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS Cyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2 positive regulation of macroautophagy cyclin-dependent protein kinase regulator activity cyclin-dependent protein kinase holoenzyme complex
YAL037C-A_p YAL037C-A YAL037C-A hom Uncharacterized 0.187152058828683 0.425770706062695 no 2080 0.427574052513747 1430 NA Putative protein of unknown function biologic