strainid orf gene zyg qualifier SGTC_2906|7926292.score SGTC_2906|7926292.expt.zyg.pval SGTC_2906|7926292.expt.zyg.significant SGTC_2906|7926292.expt.zyg.rank strain.pval strain.rank clearance Fclass Fterms.BP Fterms.CC Fterms.complex description GO_process GO_function GO_component
YOR104W YOR104W PIN2 hom Verified 6.5446606085067 2.98153247596934e-11 yes 1 1.1232670503769e-10 6 NA Protein that induces appearance of [PIN+] prion when overproduced; predicted to be palmitoylated biological_process molecular_function cellular_component
YMR044W YMR044W IOC4 hom Verified 6.38960877945328 8.31553470149769e-11 yes 2 2.21321991196819e-09 7 NA FT CHROMATIN ORGANIZATION NUCLEUS Member of a complex (Isw1b) with Isw1p and Ioc2p; interacts directly with H3K36me3 nucleosomes through its PWWP domain to recruit the Isw1b complex to open reading frames in a Set2p-dependent manner; Isw1b exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing chromatin remodeling nucleosome binding|ATPase activity|DNA binding ISW1 complex
YFR041C YFR041C ERJ5 hom Verified 5.80482391783276 3.22168407290038e-09 yes 3 9.56301921253176e-10 2 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Type I membrane protein with a J domain is required to preserve the folding capacity of the endoplasmic reticulum; loss of the non-essential ERJ5 gene leads to a constitutively induced unfolded protein response protein folding molecular_function endoplasmic reticulum
YGL186C YGL186C TPN1 hom Verified 5.76626040132043 4.05248989682209e-09 yes 4 0.000160612536993416 48 NA FF|FT PLASMA MEMBRANE Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p vitamin transport vitamin transporter activity integral to membrane|plasma membrane
YPL058C YPL058C PDR12 hom Verified 5.73753361668127 4.80326081301651e-09 yes 5 5.16113267632644e-09 2 NA FT KETONE METABOLISM|NUCLEOTIDE METABOLISM PLASMA MEMBRANE Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity propionate metabolic process|transport|organic acid transport xenobiotic-transporting ATPase activity|organic acid transmembrane transporter activity integral to membrane|plasma membrane
YDR535C_d YDR535C YDR535C hom Dubious 5.59621051384155 1.09543828587801e-08 yes 6 4.99735500667072e-08 6 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YDR535C is not an essential gene. Unknown Unknown Unknown
YLR372W YLR372W SUR4 hom Verified 5.56381518271903 1.31969741365177e-08 yes 7 0.000478186623815974 84 NA FF|FT VESICLE-MEDIATED TRANSPORT|KETONE METABOLISM|LIPID METABOLISM ENDOPLASMIC RETICULUM Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis post-Golgi vesicle-mediated transport|fatty acid elongation|fatty acid biosynthetic process|sphingolipid biosynthetic process fatty acid elongase activity integral to membrane|endoplasmic reticulum
YJR025C YJR025C BNA1 hom Verified 5.54162473441114 1.49838995425167e-08 yes 8 3.79895759029712e-08 3 NA FT OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM NUCLEUS 3-hydroxyanthranilic acid dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p de novo NAD biosynthetic process from tryptophan 3-hydroxyanthranilate 3,4-dioxygenase activity cytoplasm
YMR294W YMR294W JNM1 hom Verified 5.45358806811083 2.46817403272432e-08 yes 9 6.16642812102475e-07 14 NA FF|FT CELL CYCLE|CYTOSKELETON ORGANIZATION CYTOSKELETON Component of the yeast dynactin complex, consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B nuclear migration|establishment of mitotic spindle orientation structural constituent of cytoskeleton dynactin complex|cell cortex|spindle pole body|astral microtubule
YNL098C YNL098C RAS2 hom Verified 4.98506369039893 3.09707027639681e-07 yes 10 6.29853220411359e-06 11 NA FT PROTEIN LOCALIZATION|SIGNALING|NUCLEOTIDE METABOLISM|RESPONSE TO NUTRIENT LEVELS PLASMA MEMBRANE GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes pseudohyphal growth|ascospore formation|activation of adenylate cyclase activity|regulation of protein localization|replicative cell aging|positive regulation of transcription by galactose|Ras protein signal transduction GTP binding|GTPase activity plasma membrane
YJR070C YJR070C LIA1 hom Verified 4.69700460421833 1.32002251365298e-06 yes 11 2.90801775156635e-06 13 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CYTOSKELETON ORGANIZATION NUCLEUS Deoxyhypusine hydroxylase; HEAT-repeat containing metalloenzyme that catalyzes hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning; protein abundance increases in response to DNA replication stress microtubule cytoskeleton organization|peptidyl-lysine modification to hypusine deoxyhypusine monooxygenase activity nucleus|cytoplasm
YLR312C_p YLR312C YLR312C hom Uncharacterized 4.68581965891719 1.39420857988849e-06 yes 12 2.77754652679462e-06 2 NA Putative protein of unknown function biological_process molecular_function cellular_component
YNL316C YNL316C PHA2 hom Verified 4.58239311236211 2.29842344787105e-06 yes 13 6.43263979806987e-07 6 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Prephenate dehydratase, catalyzes the conversion of prephanate to phenylpyruvate, which is a step in the phenylalanine biosynthesis pathway L-phenylalanine biosynthetic process prephenate dehydratase activity cytoplasm
YDR363W-A YDR363W-A SEM1 hom Verified 4.55367192175467 2.63587751764077e-06 yes 14 2.47303128299278e-06 7 NA FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|PROTEOLYSIS|RNA LOCALIZATION NUCLEUS Component of lid subcomplex of the 26S proteasome regulatory subunit; involved in mRNA export mediated by the TREX-2 complex (Sac3p-Thp1p); ortholog of human DSS1; protein abundance increases in response to DNA replication stress proteasome assembly|proteasomal ubiquitin-dependent protein catabolic process|regulation of cell cycle|mRNA export from nucleus|exocytosis|filamentous growth|ubiquitin-dependent protein catabolic process molecular_function cytosol|nucleus|proteasome storage granule|proteasome regulatory particle, lid subcomplex
YMR021C YMR021C MAC1 hom Verified 4.49033449571552 3.55557057617549e-06 yes 15 0.00228489448458231 108 NA FF|FT TRANSCRIPTION FROM RNA POL II|ION HOMEOSTASIS|ION HOMEOSTASIS NUCLEUS Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport cellular copper ion homeostasis|positive regulation of protein catabolic process|positive regulation of transcription from RNA polymerase II promoter core promoter proximal region DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YOR316C YOR316C COT1 hom Verified 4.47115853099498 3.88985001686783e-06 yes 16 1.10334454680866e-05 8 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium; protein abundance increases in response to DNA replication stress; COT1 has a paralog, ZRC1, that arose from the whole genome duplication cellular zinc ion homeostasis|cobalt ion transport|zinc ion transport cobalt ion transmembrane transporter activity|zinc ion transmembrane transporter activity|inorganic cation transmembrane transporter activity mitochondrion|integral to membrane|fungal-type vacuole
YHR137W YHR137W ARO9 hom Verified 4.30775100750238 8.24614446000547e-06 yes 17 2.98245043172033e-06 7 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Aromatic aminotransferase II, catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism aromatic amino acid family metabolic process aromatic-amino-acid:2-oxoglutarate aminotransferase activity nucleus|cytoplasm
YHR181W YHR181W SVP26 hom Verified 4.25279586151033 1.05559007619441e-05 yes 18 2.60624161746817e-05 13 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment protein retention in Golgi apparatus|fungal-type cell wall organization|protein glycosylation|ER to Golgi vesicle-mediated transport COPII adaptor activity integral to endoplasmic reticulum membrane|integral to membrane|endoplasmic reticulum|integral to Golgi membrane|ER to Golgi transport vesicle
YGL062W YGL062W PYC1 hom Verified 4.20157315008688 1.32533284202327e-05 yes 19 5.18893960562037e-06 8 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc2p; mutations in the human homolog are associated with lactic acidosis; PYC1 has a paralog, PYC2, that arose from the whole genome duplication NADPH regeneration|gluconeogenesis pyruvate carboxylase activity cytosol
YBL075C YBL075C SSA3 hom Verified 4.18084223275627 1.45215664962247e-05 yes 20 2.43661876921642e-05 22 NA FT PROTEIN LOCALIZATION ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm; SSA3 has a paralog, SSA4, that arose from the whole genome duplication protein folding|SRP-dependent cotranslational protein targeting to membrane, translocation|response to stress unfolded protein binding|ATPase activity cytosol
YLR152C_p YLR152C YLR152C hom Uncharacterized 4.15685612981582 1.61328518579773e-05 yes 21 1.07299890519196e-05 4 NA Putative protein of unknown function; YLR152C is not an essential gene biological_process molecular_function integral to membrane
YDL231C YDL231C BRE4 hom Verified 4.05235666787454 2.53521438726082e-05 yes 22 2.40610222029603e-05 11 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION Zinc finger protein containing five transmembrane domains; null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect intracellular transport endocytosis molecular_function integral to membrane
YPR040W YPR040W TIP41 hom Verified 4.02172766375303 2.88864157409203e-05 yes 23 7.82972560271465e-05 25 NA FT SIGNALING NUCLEUS Protein that interacts with Tap42p, which regulates PP2A; component of the TOR (target of rapamycin) signaling pathway; protein abundance increases in response to DNA replication stress signal transduction molecular_function nucleus|cytoplasm
YJL123C YJL123C MTC1 hom Verified 3.98484070982702 3.37627035321781e-05 yes 24 5.15724295478582e-05 13 NA FT GOLGI APPARATUS Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to COPI-coated vesicles (early Golgi); mtc1 is synthetically lethal with cdc13-1 biological_process molecular_function COPI-coated vesicle|ribosome|Golgi apparatus|cytoplasm
YDR108W YDR108W TRS85 hom Verified 3.97776950083819 3.47823785667395e-05 yes 25 0.000390306991845219 66 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION GOLGI APPARATUS Subunit of TRAPPIII (transport protein particle), a multimeric guanine nucleotide-exchange factor for Ypt1p, required for membrane expansion during autophagy and the CVT pathway; directs Ypt1p to the PAS; late post-replication meiotic role meiosis|vesicle organization|piecemeal microautophagy of nucleus|ER to Golgi vesicle-mediated transport|peroxisome degradation|macroautophagy|protein localization to pre-autophagosomal structure|CVT pathway molecular_function TRAPP complex|pre-autophagosomal structure
YGL088W_d YGL088W YGL088W hom Dubious 3.84861202446588 5.9394485909777e-05 yes 26 9.60317898103015e-05 14 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps snR10, a snoRNA required for preRNA processing Unknown Unknown Unknown
YJR018W_d YJR018W YJR018W hom Dubious 3.84732335216759 5.97076595435375e-05 yes 27 0.000144682878145206 30 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YEL054C YEL054C RPL12A hom Verified 3.79880032026819 7.26990862054739e-05 yes 28 6.0639094842042e-05 13 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication cytoplasmic translation|ribosomal large subunit assembly structural constituent of ribosome cytosolic large ribosomal subunit
YJL136C YJL136C RPS21B hom Verified 3.7971564588275 7.31827072449935e-05 yes 29 8.73052700501457e-05 27 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|cytoplasmic translation|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit
YFL025C YFL025C BST1 hom Verified 3.73946068776895 9.2207742349385e-05 yes 30 0.00162581243999907 88 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|PROTEOLYSIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules protein retention in ER lumen|vesicle organization|ER-associated protein catabolic process|ER to Golgi vesicle-mediated transport|GPI anchor metabolic process phosphatidylinositol deacylase activity integral to membrane|endoplasmic reticulum
YMR262W_p YMR262W YMR262W hom Uncharacterized 3.7305000235702 9.55500627465461e-05 yes 31 6.5454888190544e-05 20 NA Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene biological_process molecular_function cellular_component
YDL160C YDL160C DHH1 hom Verified 3.72964067134117 9.58765149763342e-05 yes 32 0.000545170149148525 52 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION|RNA LOCALIZATION Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping; coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, may have a role in mRNA export and translation; C-terminus of Dhh1p interacts with Ngr1p and promotes POR1, but not EDC1 mRNA decay; forms cytoplasmic foci upon DNA replication stress deadenylation-dependent decapping of nuclear-transcribed mRNA|cell morphogenesis involved in conjugation with cellular fusion|stress granule assembly|cytoplasmic mRNA processing body assembly protein binding|RNA helicase activity cytoplasmic mRNA processing body|cytoplasmic stress granule|cytoplasm
YMR143W YMR143W RPS16A hom Verified 3.70768417959848 0.000104581641787561 yes 33 0.00015116543700273 25 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16A has a paralog, RPS16B, that arose from the whole genome duplication cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit|90S preribosome
YOL124C YOL124C TRM11 hom Verified 3.70074856947985 0.000107482195906908 yes 34 7.15313879121344e-05 20 NA FT RNA PROCESSING Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain tRNA methylation S-adenosylmethionine-dependent methyltransferase activity|RNA binding|tRNA (guanine-N2-)-methyltransferase activity cytoplasm|tRNA (m2G10) methyltransferase complex
YDL137W YDL137W ARF2 hom Verified 3.66813329570477 0.000122163901890371 yes 35 0.0001714669318975 18 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|RESPONSE TO NUTRIENT LEVELS GOLGI APPARATUS ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; ARF2 has a paralog, ARF1, that arose from the whole genome duplication ER to Golgi vesicle-mediated transport|macroautophagy|intra-Golgi vesicle-mediated transport GTPase activity cytosol|Golgi-associated vesicle
YIR023W YIR023W DAL81 hom Verified 3.5802038185568 0.00017166315166963 yes 36 0.0250273838680795 334 NA FF|FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|RESPONSE TO NUTRIENT LEVELS NUCLEUS Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism nitrogen utilization|nitrogen catabolite activation of transcription from RNA polymerase II promoter|gamma-aminobutyric acid catabolic process|urea catabolic process RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor recruiting transcription factor activity nucleus
YDR293C YDR293C SSD1 hom Verified 3.49764499447536 0.000234692742911109 yes 37 0.0175477844642198 233 NA FF|FT CELL CYCLE|TRANSLATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION|RNA LOCALIZATION NUCLEUS|SITE OF POLARIZED GROWTH Translational repressor with a role in polar growth and wall integrity; regulated by Cbk1p phosphorylation to effect bud-specific translational control and localization of specific mRNAs; interacts with TOR pathway components; contains a functional N-terminal nuclear localization sequence and nucleocytoplasmic shuttling appears to be critical to Ssd1p function regulation of fungal-type cell wall organization|negative regulation of translation|intracellular mRNA localization mRNA binding|mRNA 5'-UTR binding|translation repressor activity, nucleic acid binding nucleus|cellular bud|cytoplasmic stress granule|cytoplasmic mRNA processing body|cellular bud neck|cytoplasm
YBL056W YBL056W PTC3 hom Verified 3.4688728159691 0.000261323406333099 yes 38 0.000167126740510234 22 NA FT CELL CYCLE|SIGNALING|PROTEIN PHOSPHORYLATION NUCLEUS Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress; dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p); role in DNA damage checkpoint inactivation; PTC3 has a paralog, PTC2, that arose from the whole genome duplication inactivation of MAPK activity involved in osmosensory signaling pathway|regulation of cyclin-dependent protein kinase activity|protein dephosphorylation protein serine/threonine phosphatase activity nucleus|cytoplasm
YKR048C YKR048C NAP1 hom Verified 3.44579091409374 0.000284695363793226 yes 39 0.000280332519248199 34 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION NUCLEUS|SITE OF POLARIZED GROWTH|CHROMOSOME Protein that interacts with mitotic cyclin Clb2p; required for the regulation of microtubule dynamics during mitosis; controls bud morphogenesis; involved in the transport of H2A and H2B histones to the nucleus; phosphorylated by CK2; protein abundance increases in response to DNA replication stress budding cell bud growth|M phase of mitotic cell cycle|nucleosome disassembly|protein import into nucleus|nucleosome assembly cyclin binding|histone binding nucleus|nuclear nucleosome|cytoplasm
YFR030W YFR030W MET10 hom Verified 3.40132707963302 0.000335297696839508 yes 40 0.000376546307043451 35 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY Subunit alpha of assimilatory sulfite reductase, which converts sulfite into sulfide sulfate assimilation sulfite reductase (NADPH) activity sulfite reductase complex (NADPH)
YJR073C YJR073C OPI3 hom Verified 3.38146021594516 0.000360508364001061 yes 41 0.00297998209905251 121 NA FF|FT LIPID METABOLISM MITOCHONDRION Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis phosphatidylcholine biosynthetic process phosphatidyl-N-dimethylethanolamine N-methyltransferase activity|phosphatidyl-N-methylethanolamine N-methyltransferase activity mitochondrion|integral to membrane
YPR064W_d YPR064W YPR064W hom Dubious 3.35600870888554 0.000395380393126082 yes 42 0.000523293143624152 38 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YHR037W YHR037W PUT2 hom Verified 3.35246440322529 0.000400477703131129 yes 43 0.00084587305312398 36 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION Delta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism glutamate biosynthetic process|proline catabolic process to glutamate 1-pyrroline-5-carboxylate dehydrogenase activity mitochondrion|mitochondrial matrix
YKL211C YKL211C TRP3 hom Verified 3.3335553350871 0.000428718071211234 yes 44 0.0879265817896468 558 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p tryptophan biosynthetic process indole-3-glycerol-phosphate synthase activity|anthranilate synthase activity anthranilate synthase complex|cytoplasm
YGL085W_p YGL085W LCL3 hom Uncharacterized 3.2974768710648 0.000487788545802898 yes 45 0.000249526487349192 15 NA FT MITOCHONDRION Putative protein of unknown function; mutant has long chronological lifespan; has homology to Staphylococcus aureus nuclease; GFP-fusion protein localizes to mitochondria; is induced in response to the DNA-damaging agent MMS biological_process molecular_function mitochondrion
YAL054C YAL054C ACS1 hom Verified 3.29683220030628 0.000488909507927311 yes 46 0.000127141301338984 13 NA FT KETONE METABOLISM|CHROMATIN ORGANIZATION|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetylation; expressed during growth on nonfermentable carbon sources and under aerobic conditions acetate fermentation|histone acetylation|acetyl-CoA biosynthetic process acetate-CoA ligase activity|acid-ammonia (or amide) ligase activity cytosol|mitochondrion|integral to membrane
YKL033W-A_p YKL033W-A YKL033W-A hom Uncharacterized 3.2933756683119 0.000494960561836966 yes 47 0.00140005475886828 52 NA Putative protein of unknown function; similar to uncharacterized proteins from other fungi biological_process molecular_function cellular_component
YLR445W YLR445W GMC2 hom Verified 3.29146660852716 0.000498332240113253 yes 48 0.000362057693927606 28 NA FT CELL CYCLE Protein involved in meiotic progression; mutants are delayed in meiotic nuclear division and are defective in synaptonemal complex assembly; transcription is regulated by Ume6p and induced in response to alpha factor meiosis|synaptonemal complex organization molecular_function cellular_component
YDL011C_d YDL011C YDL011C hom Dubious 3.28832968560861 0.000503918713569893 yes 49 0.000297628761788509 15 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized ORF YDL010W Unknown Unknown Unknown
YOL107W_p YOL107W YOL107W hom Uncharacterized 3.26836794647102 0.000540848206348184 yes 50 0.000314306415127785 24 NA FT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and colocalizes in a punctate pattern with the early golgi/COPI vesicles; YOL107W is not an essential protein biological_process molecular_function COPI-coated vesicle|Golgi apparatus
YIR002C YIR002C MPH1 hom Verified 3.26532967017415 0.000546683708057651 yes 51 0.000882988393427803 34 NA FT RESPONSE TO DNA DAMAGE NUCLEUS 3'-5' DNA helicase involved in error-free bypass of DNA lesions; binds to flap DNA in an error-free bypass pathway and stimulates the activity of Rad27p and Dna2p; also involved in interstrand cross-link repair mutations confer a mutator phenotype; similarity to FANCM, a human Fanconi anemia complementation group protein that along with the MHF complex is involved in stabilizing and remodeling blocked replication forks; member of the SF2 DExD/H superfamily of helicases negative regulation of strand invasion|recombinational repair|DNA replication, Okazaki fragment processing flap-structured DNA binding|3'-5' DNA helicase activity nucleus
YCR019W YCR019W MAK32 hom Verified 3.20855822015442 0.000667011486056991 yes 52 0.000524446113127891 21 NA Protein necessary for structural stability of L-A double-stranded RNA-containing particles interspecies interaction between organisms molecular_function cellular_component
YBR163W YBR163W EXO5 hom Verified 3.19162430949483 0.000707376089883605 yes 53 0.00133784615504881 67 NA FT MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial 5'-3' exonuclease and sliding exonuclease, required for mitochondrial genome maintenance; distantly related to the RecB nuclease domain of bacterial RecBCD recombinases; may be regulated by the transcription factor Ace2 mitochondrial genome maintenance single-stranded DNA specific 5'-3' exodeoxyribonuclease activity mitochondrion
YPL025C_d YPL025C YPL025C hom Dubious 3.18895737055066 0.000713934662534793 yes 54 0.00095697124234553 37 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YBR026C YBR026C ETR1 hom Verified 3.15095138701949 0.000813697871537518 yes 55 0.00157514673400674 50 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION 2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family; localized to in mitochondria, where it has a probable role in fatty acid synthesis fatty acid biosynthetic process|aerobic respiration enoyl-[acyl-carrier-protein] reductase activity mitochondrion
YPL236C YPL236C ENV7 hom Verified 3.14639849369469 0.000826473130811922 yes 56 0.000288096480464252 32 NA FT PROTEIN PHOSPHORYLATION|VACUOLAR PROTEIN PROCESSING Vacuolar membrane protein kinase; negatively regulates membrane fusion; associates with vacuolar membrane through palmitoylation of one or more cysteines in consensus sequence; vacuolar membrane association is essential to its kinase activity; mutant shows defect in CPY processing; ortholog of human serine/threonine kinase 16 (STK16) vacuolar protein processing protein serine/threonine kinase activity fungal-type vacuole membrane
YMR125W YMR125W STO1 hom Verified 3.13114050138681 0.000870644158012043 yes 57 0.00245140174657543 60 NA FT RNA PROCESSING|RNA LOCALIZATION NUCLEUS Large subunit of the nuclear mRNA cap-binding protein complex, interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|mRNA splicing, via spliceosome|response to osmotic stress mRNA binding commitment complex|nuclear cap binding complex|polysome
YBL046W YBL046W PSY4 hom Verified 3.11822519122767 0.000909718641213278 yes 58 0.000717409349663783 74 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS Regulatory subunit of protein phosphatase PP4; presence of Psy4p in the PP4 complex (along with catalytic subunit Pph3p and Psy2p) is required for dephosphorylation of the histone variant H2AX, but not for dephosphorylation of Rad53p, during recovery from the DNA damage checkpoint; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; required for cisplatin resistance; homolog of mammalian R2 Unknown|protein dephosphorylation protein phosphatase regulator activity nucleus|cytoplasm
YDR028C YDR028C REG1 hom Verified 3.10879550133067 0.000939258450746648 yes 59 0.017161718160628 234 NA FF|FT TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Regulatory subunit of type 1 protein phosphatase Glc7p; involved in negative regulation of glucose-repressible genes; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p cellular response to glucose starvation|vacuolar protein catabolic process|glycogen metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of carbohydrate metabolic process protein phosphatase type 1 regulator activity protein phosphatase type 1 complex|cytoplasm
YDR354W YDR354W TRP4 hom Verified 3.10741445882579 0.000943657981123541 yes 60 0.0795106372901274 528 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis tryptophan biosynthetic process anthranilate phosphoribosyltransferase activity nucleus|cytoplasm
YAL049C YAL049C AIM2 hom Verified 3.08981402604927 0.00100140929741603 no 61 0.000569586389114279 25 NA Cytoplasmic protein involved in mitochondrial function or organization; null mutant displays reduced frequency of mitochondrial genome loss; potential Hsp82p interactor biological_process molecular_function cytoplasm
YJR121W YJR121W ATP2 hom Verified 3.07825008934298 0.00104110046376584 no 62 0.000819731060502288 52 NA FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS MITOCHONDRION Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated ATP synthesis coupled proton transport hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism proton-transporting ATP synthase complex, catalytic core F(1)|mitochondrion|mitochondrial proton-transporting ATP synthase, catalytic core|integral to membrane
YBR040W YBR040W FIG1 hom Verified 3.0697442305481 0.00107121078898247 no 63 0.00059398588998496 33 NA FT SITE OF POLARIZED GROWTH Integral membrane protein required for efficient mating; may participate in or regulate the low affinity Ca2+ influx system, which affects intracellular signaling and cell-cell fusion during mating cell morphogenesis involved in conjugation with cellular fusion|cytogamy molecular_function fungal-type cell wall|integral to membrane|mating projection tip
YNR049C YNR049C MSO1 hom Verified 3.06664038849592 0.00108239562366808 no 64 0.00102367617123838 39 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Probable component of the secretory vesicle docking complex; acts at a late step in secretion; shows genetic and physical interactions with Sec1p; required for prospore membrane formation during sporulation; relocalizes from bud neck to nucleus upon DNA replication stress cellular membrane fusion|ascospore-type prospore membrane assembly|vesicle docking involved in exocytosis molecular_function SNARE complex|cellular bud membrane|plasma membrane|prospore membrane|cellular bud neck|cellular bud tip
YNL271C YNL271C BNI1 hom Verified 3.06328070760937 0.00109462297198426 no 65 0.00612592349059013 89 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1 barbed-end actin filament capping|actin nucleation|actin filament bundle assembly involved in cytokinetic actomyosin contractile ring assembly|establishment of mitotic spindle orientation|formin-nucleated actin cable assembly profilin binding incipient cellular bud site|actin filament|polarisome|plasma membrane|cellular bud neck|mating projection tip|cellular bud tip
YBR231C YBR231C SWC5 hom Verified 3.05392406035779 0.00112934623887781 no 66 0.00669276595920734 139 NA FF|FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Component of the SWR1 complex; complex exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; protein abundance increases in response to DNA replication stress chromatin remodeling|histone exchange molecular_function Swr1 complex|nucleus
YNR036C YNR036C MRPS12 hom Verified 3.03339248877491 0.00120910430031561 no 67 0.00192449850553094 83 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial protein; may interact with ribosomes based on co-purification experiments; similar to E. coli and human mitochondrial S12 ribosomal proteins mitochondrial translation structural constituent of ribosome mitochondrion|ribosome|mitochondrial small ribosomal subunit
YOL155C YOL155C HPF1 hom Verified 3.02367856037401 0.00124860806345085 no 68 0.00181793458333288 46 NA FT CELL WALL ORG/BIOGENESIS Haze-protective mannoprotein that reduces the particle size of aggregated proteins in white wines fungal-type cell wall organization glucosidase activity fungal-type cell wall|extracellular region
YKL093W YKL093W MBR1 hom Verified 3.01971927329681 0.00126504537528429 no 69 0.000907574332549622 30 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants aerobic respiration molecular_function cellular_component
YJL099W YJL099W CHS6 hom Verified 3.01115960556494 0.00130126008269266 no 70 0.00265075841812812 73 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM GOLGI APPARATUS Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication Golgi to plasma membrane transport|fungal-type cell wall chitin biosynthetic process molecular_function trans-Golgi network transport vesicle|clathrin-coated vesicle|exomer complex
YMR221C_p YMR221C YMR221C hom Uncharacterized 3.00663453791398 0.00132078566170391 no 71 0.000786904899266984 36 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; physical interaction with Atg27p suggests a possible role in autophagy biological_process molecular_function mitochondrion|integral to membrane|fungal-type vacuole
YPR089W_p YPR089W YPR089W hom Uncharacterized 3.00511239629946 0.00132741362904073 no 72 0.00168283175303308 48 NA FT GOLGI APPARATUS Protein of unknown function; exhibits genetic interaction with ERG11 and protein-protein interaction with Hsp82p biological_process molecular_function cellular_component
YOR357C YOR357C SNX3 hom Verified 3.0010562864124 0.00134522414060311 no 73 0.00150048018277994 75 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p protein localization|late endosome to Golgi transport phosphatidylinositol-3-phosphate binding cytosol|endosome
YCR064C_d YCR064C YCR064C hom Dubious 2.99648285550239 0.00136556797546863 no 74 0.00485934899929061 101 NA FF Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31 Unknown Unknown Unknown
YNL109W_d YNL109W YNL109W hom Dubious 2.99335177252374 0.00137965753531376 no 75 0.00149787739756109 37 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YNL108C Unknown Unknown Unknown
YCR087C-A_p YCR087C-A YCR087C-A hom Uncharacterized 2.99255692828016 0.00138325532607593 no 76 0.00211141036576688 78 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YCR087C-A is not an essential gene biological_process molecular_function nucleolus
YCR066W YCR066W RAD18 hom Verified 2.97468144852123 0.0014664647113223 no 77 0.00349813685101759 104 NA FF|FT RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME E3 ubiquitin ligase; forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; required for postreplication repair; SUMO-targeted ubiquitin ligase (STUbl) that contains a SUMO-interacting motif (SIM) which stimulates its ubiquitin ligase activity towards the sumoylated form of PCNA protein monoubiquitination|error-free translesion synthesis|error-free postreplication DNA repair|error-prone translesion synthesis ubiquitin-protein ligase activity|single-stranded DNA-dependent ATPase activity|single-stranded DNA binding nuclear chromatin|nucleus
YNR012W YNR012W URK1 hom Verified 2.96905296598642 0.00149359551118837 no 78 0.00204146343409013 53 NA FT NUCLEOTIDE METABOLISM NUCLEUS Uridine/cytidine kinase, component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP; involved in the pyrimidine deoxyribonucleotide salvage pathway, converting deoxycytidine into dCMP pyrimidine-containing compound salvage uridine kinase activity nucleus|cytoplasm
YOR290C YOR290C SNF2 hom Verified 2.9557861554944 0.00155936620843181 no 79 0.0168801244617634 143 NA FF|FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS NUCLEUS RSC COMPLEX Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p cellular alcohol catabolic process|ATP-dependent chromatin remodeling|double-strand break repair|strand invasion|positive regulation of mating type switching|sucrose catabolic process|positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation|nucleosome mobilization|chromatin remodeling|DNA-dependent DNA replication|positive regulation of transcription from RNA polymerase II promoter histone acetyl-lysine binding|RNA polymerase II activating transcription factor binding|DNA-dependent ATPase activity|nucleosomal DNA binding SWI/SNF complex|nucleus
YGL023C YGL023C PIB2 hom Verified 2.95298431877524 0.00157358974905352 no 80 0.00214056664410459 43 NA FT VESICLE-MEDIATED TRANSPORT MITOCHONDRION Protein of unknown function; contains FYVE domain; similar to Fab1 and Vps27 biological_process molecular_function mitochondrion
YKL068W YKL068W NUP100 hom Verified 2.94803115023623 0.00159902418896536 no 81 0.00105756623014232 33 NA FT PROTEIN LOCALIZATION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; homologous to Nup116p positive regulation of transcription, DNA-dependent|mRNA export from nucleus|NLS-bearing substrate import into nucleus|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|protein import into nucleus|protein targeting to nuclear inner membrane|mRNA export from nucleus in response to heat stress nucleocytoplasmic transporter activity|structural constituent of nuclear pore nuclear pore central transport channel|integral to membrane|nuclear pore
YNL230C YNL230C ELA1 hom Verified 2.93191505190107 0.00168439439908562 no 82 0.00229218048148864 52 NA FT PROTEOLYSIS NUCLEUS UBIQUITIN LIGASE COMPLEX Elongin A; F-box protein that forms a heterodimer with Elc1p and is required for ubiquitin-dependent degradation of the RNA Polymerase II subunit Rpo21p; subunit of the Elongin-Cullin-Socs (ECS) ligase complex protein ubiquitination involved in ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity elongin complex|Cul3-RING ubiquitin ligase complex
YER128W YER128W VFA1 hom Verified 2.91955721970549 0.00175264518367421 no 83 0.0017176701808629 54 NA FT VACUOLAR TRANSPORT Protein that interacts with Vps4p and has a role in vacuolar sorting; localizes to endosomes in a Vps4-dependent manner; overexpression causes canavanine sensitivity and confers a partial class D vacuole morphology vacuolar transport molecular_function endosome|cytoplasm
YDR069C YDR069C DOA4 hom Verified 2.91937577419205 0.00175366576722358 no 84 0.00335569589753372 93 NA FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|PROTEOLYSIS MITOCHONDRION Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole protein deubiquitination|endocytosis|regulation of DNA replication|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|free ubiquitin chain depolymerization|ubiquitin homeostasis|ubiquitin-dependent protein catabolic process endopeptidase activity|ubiquitin-specific protease activity|ubiquitin thiolesterase activity endosome|proteasome complex|mitochondrion
YAL011W YAL011W SWC3 hom Verified 2.908215884318 0.00181748653402367 no 85 0.0052656754549548 146 NA FF|FT CHROMATIN ORGANIZATION NUCLEUS|MITOCHONDRION|CHROMOSOME Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae endoplasmic reticulum organization|chromatin remodeling|histone exchange molecular_function mitochondrion|Swr1 complex|nucleus
YHR045W_p YHR045W YHR045W hom Uncharacterized 2.90462961265094 0.0018384396479252 no 86 0.00152214220581886 77 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS ENDOPLASMIC RETICULUM Putative protein of unknown function; possible role in iron metabolism and/or amino acid and carbohydrate metabolism; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum biological_process molecular_function endoplasmic reticulum
YML117W YML117W NAB6 hom Verified 2.88311456473157 0.00196882101303189 no 87 0.00173483331051682 59 NA Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP biological_process molecular_function cytoplasm
YDR137W YDR137W RGP1 hom Verified 2.8539497481544 0.0021589680422667 no 88 0.0246993237322839 161 NA FF|FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|CELL DIVISION ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p retrograde transport, endosome to Golgi guanyl-nucleotide exchange factor activity Golgi apparatus|Ric1p-Rgp1p complex|Golgi membrane|guanyl-nucleotide exchange factor complex
YDR495C YDR495C VPS3 hom Verified 2.85187635500094 0.00217310013165118 no 89 0.00737745761135845 131 NA FF|FT PROTEIN LOCALIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT Component of CORVET tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase vacuole inheritance|vacuolar acidification|protein targeting to vacuole molecular_function CORVET complex|cytoplasm
YMR315W YMR315W YMR315W hom Verified 2.84821766138788 0.00219824221051995 no 90 0.00242489094633336 64 NA FT OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM NUCLEUS Protein with NADP(H) oxidoreductase activity; transcription is regulated by Stb5p in response to NADPH depletion induced by diamide; promoter contains a putative Stb5p binding site; protein abundance increases in response to DNA replication stress NADPH regeneration oxidoreductase activity nucleus|cytoplasm
YBL011W YBL011W SCT1 hom Verified 2.84679013834976 0.00220812326189581 no 91 0.00241175093232032 61 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase of the glycerolipid biosynthesis pathway, prefers 16-carbon fatty acids, similar to Gpt2p, gene is constitutively transcribed phospholipid biosynthetic process glycerol-3-phosphate O-acyltransferase activity|glycerone-phosphate O-acyltransferase activity integral to membrane|endoplasmic reticulum
YBR030W YBR030W RKM3 hom Verified 2.82900263945303 0.00233466569304835 no 92 0.00106916741700034 32 NA FT NUCLEUS Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 40); nuclear SET domain containing protein peptidyl-lysine monomethylation protein-lysine N-methyltransferase activity nucleus
YJL100W YJL100W LSB6 hom Verified 2.82137761928861 0.00239089392578172 no 93 0.00296648603703373 72 NA FT LIPID METABOLISM PLASMA MEMBRANE Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization phosphatidylinositol phosphorylation 1-phosphatidylinositol 4-kinase activity fungal-type vacuole membrane|plasma membrane|cytoplasm
YAR002W YAR002W NUP60 hom Verified 2.8210991641584 0.00239297030453377 no 94 0.00495529194625277 68 NA FT PROTEIN LOCALIZATION|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; both NUP1 and NUP60 are homologous to human NUP153 double-strand break repair|poly(A)+ mRNA export from nucleus|protein export from nucleus|regulation of protein desumoylation|intracellular mRNA localization|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|telomere tethering at nuclear periphery|mRNA export from nucleus in response to heat stress|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery|NLS-bearing substrate import into nucleus|chromosome organization|nucleocytoplasmic transport|chromatin silencing at silent mating-type cassette nucleocytoplasmic transporter activity|phospholipid binding|structural constituent of nuclear pore nuclear pore central transport channel|nuclear pore nuclear basket|integral to membrane|nuclear pore
YPL177C YPL177C CUP9 hom Verified 2.81584750644482 0.0024324376067115 no 95 0.00288698054554252 65 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Homeodomain-containing transcriptional repressor; regulates expression of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription; CUP9 has a paralog, TOS8, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter|negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter RNA polymerase II repressing transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity nucleus
YKL206C YKL206C ADD66 hom Verified 2.80877133535754 0.00248654776708528 no 96 0.00193339334708019 39 NA FT PROTEIN COMPLEX ORG/BIOGENESIS Protein involved in 20S proteasome assembly; forms a heterodimer with Pba1p that binds to proteasome precursors; similar to human PAC2 constituent of the PAC1-PAC2 complex involved in proteasome assembly proteasome assembly molecular_function cytosol|cytoplasm
YPR121W YPR121W THI22 hom Verified 2.79856193817404 0.00256653618309664 no 97 0.00187218797149177 39 NA Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis thiamine biosynthetic process phosphomethylpyrimidine kinase activity|hydroxymethylpyrimidine kinase activity cellular_component
YHR086W-A_p YHR086W-A YHR086W-A hom Uncharacterized 2.78812854814792 0.00265067516847553 no 98 0.00217516720873473 45 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YLR278C_p YLR278C YLR278C hom Uncharacterized 2.78239769291814 0.00269794373137229 no 99 0.00409113456676466 44 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Zinc-cluster protein; GFP-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; has a prion-domain like fragment that increases frequency of [URE3]; YLR278C is not an essential gene biological_process sequence-specific DNA binding nucleus
YCR073W-A YCR073W-A SOL2 hom Verified 2.77556866966953 0.0027552630492372 no 100 0.00397629795361453 85 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|RNA LOCALIZATION|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL2 has a paralog, SOL1, that arose from the whole genome duplication tRNA export from nucleus molecular_function|6-phosphogluconolactonase activity cytosol|cytoplasm
YJL047C YJL047C RTT101 hom Verified 2.76824065987766 0.00281799104981538 no 101 0.00576981834984903 110 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|PROTEOLYSIS NUCLEUS UBIQUITIN LIGASE COMPLEX Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex with a role in anaphase progression; implicated in Mms22-dependent DNA repair; involved with Mms1p in nonfunctional rRNA decay; modified by the ubiquitin-like protein, Rub1p replication fork processing|negative regulation of transposition, RNA-mediated|regulation of mitosis|nonfunctional rRNA decay|ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity Cul8-RING ubiquitin ligase complex|nucleus|cytoplasm
YML122C_d YML122C YML122C hom Dubious 2.7565221298009 0.00292098297163122 no 102 0.0360330490922904 267 NA FF Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YBL006C YBL006C LDB7 hom Verified 2.74987565852892 0.00298089413532888 no 103 0.0216702342622107 223 NA FF|FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|CELL WALL ORG/BIOGENESIS NUCLEUS RSC COMPLEX Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions ATP-dependent chromatin remodeling|cell wall mannoprotein biosynthetic process|nucleosome disassembly|transcription elongation from RNA polymerase II promoter DNA translocase activity RSC complex
YBR059C YBR059C AKL1 hom Verified 2.74948586588968 0.00298444185221096 no 104 0.00341347996070671 50 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION SITE OF POLARIZED GROWTH Ser-Thr protein kinase, member (with Ark1p and Prk1p) of the Ark kinase family; involved in endocytosis and actin cytoskeleton organization regulation of endocytosis|protein phosphorylation|actin cytoskeleton organization protein kinase activity cellular bud neck|cytoplasm
YOR036W YOR036W PEP12 hom Verified 2.73739866858616 0.00309635975108122 no 105 0.0111405800473904 183 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT GOLGI APPARATUS Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin Golgi to vacuole transport|vacuole inheritance SNAP receptor activity endosome|Golgi apparatus
YOR229W YOR229W WTM2 hom Verified 2.72140927386418 0.00325021128969637 no 106 0.00280173953296323 52 NA FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RESPONSE TO DNA DAMAGE|GENE SILENCING NUCLEUS Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; involved in response to replication stress; contains WD repeats negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of transcription from RNA polymerase II promoter during meiosis|cellular protein complex localization|negative regulation of chromatin silencing at telomere|response to DNA damage stimulus|positive regulation of transcription from RNA polymerase II promoter protein binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|transcription corepressor activity nucleus
YIL123W YIL123W SIM1 hom Verified 2.70788225144444 0.00338570210342987 no 107 0.00233143678128835 51 NA FT CELL WALL ORG/BIOGENESIS Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated fungal-type cell wall organization molecular_function fungal-type cell wall
YLR056W YLR056W ERG3 hom Verified 2.70222417260011 0.00344386532018081 no 108 0.0160212004689947 86 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM C-5 sterol desaturase, glycoprotein that catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources; substrate of the HRD ubiquitin ligase ergosterol biosynthetic process C-5 sterol desaturase activity integral to membrane|endoplasmic reticulum|endoplasmic reticulum lumen
YJL064W_d YJL064W YJL064W hom Dubious 2.69954038445192 0.00347176639963826 no 109 0.00287711159978386 52 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL065C/DLS1 Unknown Unknown Unknown
YCL025C YCL025C AGP1 hom Verified 2.69715404998973 0.00349674545965545 no 110 0.000688806579701024 36 NA FT PLASMA MEMBRANE Low-affinity amino acid permease with broad substrate range; involved in uptake of asparagine, glutamine, and other amino acids; expression regulated by SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p); AGP1 has a paralog, GNP1, that arose from the whole genome duplication amino acid transport|transmembrane transport amino acid transmembrane transporter activity|L-proline transmembrane transporter activity integral to membrane|plasma membrane
YOR059C YOR059C YOR059C hom Verified 2.68954903343962 0.00357743174829387 no 111 0.00157822940061569 40 NA FT LIPID METABOLISM Lipid particle protein of unknown function; contains a putative lipase serine active site; induced by transcription factor Rpn4p; protein abundance increases in response to DNA replication stress biological_process molecular_function lipid particle
YML118W YML118W NGL3 hom Verified 2.6889831291182 0.0035835020635621 no 112 0.00154429430859701 38 NA 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication polyadenylation-dependent RNA catabolic process poly(A)-specific ribonuclease activity|endonuclease activity cellular_component
YJR113C YJR113C RSM7 hom Verified 2.68726970656736 0.00360193793958573 no 113 0.00974130124086311 115 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S7 ribosomal protein mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YKL208W YKL208W CBT1 hom Verified 2.67587548526481 0.00372671651435966 no 114 0.00355057490669118 49 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS MITOCHONDRION Protein involved in 5' end processing of mitochondrial COB, 15S_rRNA, and RPM1 transcripts; may also have a role in 3' end processing of the COB pre-mRNA; displays genetic interaction with cell cycle-regulated kinase Dbf2p cytochrome complex assembly|mRNA processing|mRNA stabilization molecular_function mitochondrion
YDR275W YDR275W BSC2 hom Verified 2.67065002668717 0.00378522661602736 no 115 0.00325532394244918 41 NA Protein of unknown function; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; BSC2 has a paralog, IRC23, that arose from the whole genome duplication biological_process molecular_function lipid particle
YCR083W YCR083W TRX3 hom Verified 2.65411044311446 0.00397588979187452 no 116 0.00387177815972769 43 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS MITOCHONDRION Mitochondrial thioredoxin, highly conserved oxidoreductase required to maintain the redox homeostasis of the cell, forms the mitochondrial thioredoxin system with Trr2p, redox state is maintained by both Trr2p and Glr1p cellular response to oxidative stress disulfide oxidoreductase activity mitochondrion
YBL022C YBL022C PIM1 hom Verified 2.65370366613414 0.0039806854706461 no 117 0.0114788689076573 131 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION|RESPONSE TO OXIDATIVE STRESS MITOCHONDRION ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria chaperone-mediated protein complex assembly|misfolded or incompletely synthesized protein catabolic process ATP-dependent peptidase activity mitochondrion|mitochondrial matrix
YDL073W_p YDL073W YDL073W hom Uncharacterized 2.63394689684608 0.00421993433424438 no 118 0.0090369235373171 76 NA Putative protein of unknown function; YDL073W is not an essential gene biological_process molecular_function cellular_component
YHL004W YHL004W MRP4 hom Verified 2.61431125360915 0.00447037725832077 no 119 0.00508950949625017 96 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit mitochondrial translation structural constituent of ribosome|tRNA binding mitochondrion|mitochondrial small ribosomal subunit
YDR182W-A_p YDR182W-A YDR182W-A hom Uncharacterized 2.60850134123844 0.0045469827673588 no 120 0.00669438947335394 80 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YHR142W YHR142W CHS7 hom Verified 2.59453065301978 0.00473600834675783 no 121 0.030683219943219 198 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein of unknown function; may be involved in chitin biosynthesis by regulation of Chs3p export from the ER; relocalizes from bud neck to ER upon DNA replication stress protein folding|ER to Golgi vesicle-mediated transport|fungal-type cell wall chitin biosynthetic process unfolded protein binding integral to membrane|endoplasmic reticulum membrane
YHR033W_p YHR033W YHR033W hom Uncharacterized 2.58305663649873 0.00489646226724724 no 122 0.00123035203789053 35 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YHR033W has a paralog, PRO1, that arose from the whole genome duplication biological_process molecular_function cytoplasm
YJL215C_d YJL215C YJL215C hom Dubious 2.56860350686243 0.00510546064417655 no 123 0.00851736946390252 75 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YIL002C YIL002C INP51 hom Verified 2.56685606967681 0.00513126000129748 no 124 0.0111325413784725 133 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION CYTOSKELETON Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in phosphatidylinositol 4,5-bisphosphate homeostasis and in endocytosis; null mutation confers cold-tolerant growth phosphatidylinositol dephosphorylation phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity membrane|cytoplasm
YBR047W_p YBR047W FMP23 hom Uncharacterized 2.56435448108999 0.0051683957080017 no 125 0.00432237808616969 54 NA FT MITOCHONDRION Putative protein of unknown function; proposed to be involved in iron or copper homeostasis; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YML123C YML123C PHO84 hom Verified 2.5629397965224 0.00518950219576391 no 126 0.0167320232649628 136 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p; cells overexpressing Pho84p accumulate heavy metals but do not develop symptoms of metal toxicity phosphate ion transport|manganese ion transport|polyphosphate metabolic process manganese ion transmembrane transporter activity|inorganic phosphate transmembrane transporter activity integral to membrane|integral to plasma membrane
YOR068C YOR068C VAM10 hom Verified 2.55422194275151 0.00532126974195358 no 127 0.00684719785126038 99 NA FT MEMBRANE ORGANIZATION Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering vacuole fusion, non-autophagic molecular_function fungal-type vacuole membrane
YJR134C YJR134C SGM1 hom Verified 2.55325105582808 0.0053361269722817 no 128 0.00451182810433561 63 NA FT GOLGI APPARATUS Protein of unknown function, required for wild-type growth rate on galactose and mannose; localizes to COPI coated vesicles and the Golgi apparatus biological_process molecular_function COPI-coated vesicle|Golgi apparatus
YMR297W YMR297W PRC1 hom Verified 2.55270403089117 0.00534451418924809 no 129 0.0017899055408232 39 NA FT PROTEOLYSIS ENDOPLASMIC RETICULUM Vacuolar carboxypeptidase Y (proteinase C; CPY), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family vacuolar protein catabolic process|phytochelatin biosynthetic process serine-type carboxypeptidase activity fungal-type vacuole lumen|endoplasmic reticulum|fungal-type vacuole|cytoplasm
YNL070W YNL070W TOM7 hom Verified 2.54294714501641 0.00549609277274837 no 130 0.0082175501127369 149 NA FF|FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex protein import into mitochondrial matrix|protein import into mitochondrial outer membrane protein channel activity mitochondrial outer membrane|mitochondrion|integral to membrane|mitochondrial outer membrane translocase complex
YGR102C YGR102C GTF1 hom Verified 2.54009039924804 0.0055411909983184 no 131 0.00602241195846496 97 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION MITOCHONDRION Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria glutaminyl-tRNAGln biosynthesis via transamidation glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity mitochondrion|glutamyl-tRNA(Gln) amidotransferase complex
YCR065W YCR065W HCM1 hom Verified 2.52311548874785 0.00581600962845004 no 132 0.00629532332112089 115 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|RESPONSE TO OXIDATIVE STRESS NUCLEUS|CHROMOSOME Forkhead transcription factor that drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere maintenance role positive regulation of transcription involved in S-phase of mitotic cell cycle|cellular response to oxidative stress|mitochondrion organization|spindle pole body organization|positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding nuclear chromatin|nucleus|cytoplasm
YMR160W YMR160W YMR160W hom Verified 2.51037134592986 0.00603021300177616 no 133 0.00675273807954111 80 NA Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; mutant has enhanced sensitivity to overexpression of mutant huntingtin; YMR160W is not an essential gene; relative distribution within the vacuolar membrane changes upon DNA replication stress biological_process molecular_function fungal-type vacuole membrane
YPL065W YPL065W VPS28 hom Verified 2.50953458910535 0.00604451877485888 no 134 0.0119247633175448 179 NA FF|FT PROTEIN LOCALIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p protein targeting to membrane|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein targeting to vacuole protein complex binding endosome|ESCRT I complex
YML017W YML017W PSP2 hom Verified 2.49252900811488 0.006341848474031 no 135 0.0112045100811784 134 NA Asn rich cytoplasmic protein that contains RGG motifs; high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha); possible role in mitochondrial mRNA splicing biological_process molecular_function cytoplasm
YEL053C YEL053C MAK10 hom Verified 2.48751950257921 0.00643187001645176 no 136 0.00500189487036248 80 NA Non-catalytic subunit of N-terminal acetyltransferase of the NatC type, required for replication of dsRNA virus; expression is glucose-repressible N-terminal protein amino acid acetylation peptide alpha-N-acetyltransferase activity NatC complex|cytoplasm
YDR216W YDR216W ADR1 hom Verified 2.48643223121829 0.00645155711920851 no 137 0.00775207232512416 74 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|CHROMATIN ORGANIZATION|OXIDATION-REDUCTION PROCESS|RESPONSE TO NUTRIENT LEVELS|GENE SILENCING|PEROXISOME ORGANIZATION NUCLEUS Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization negative regulation of chromatin silencing|positive regulation of transcription from RNA polymerase II promoter in response to ethanol|chromatin organization|regulation of transcription by chromatin organization|positive regulation of fatty acid beta-oxidation by positive regulation of transcription from RNA polymerase II promoter|positive regulation of peroxisome organization by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter by oleic acid|cellular response to oleic acid|peroxisome organization|positive regulation of ethanol catabolic process by positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|TFIIB-class transcription factor binding|sequence-specific DNA binding|TFIID-class transcription factor binding|RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription nucleus
YOR018W YOR018W ROD1 hom Verified 2.48527663237636 0.00647253984658515 no 138 0.00341846824453122 56 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION PLASMA MEMBRANE Membrane protein, binds the ubiquitin ligase Rsp5p via its 2 PY motifs; overexpression confers resistance to the GST substrate o-dinitrobenzene, zinc, and calcium; proposed to regulate the endocytosis of plasma membrane proteins; protein abundance increases in response to DNA replication stress; ROD1 has a paralog, ROG3, that arose from the whole genome duplication response to drug|ubiquitin-dependent endocytosis ubiquitin protein ligase binding plasma membrane
YGL237C YGL237C HAP2 hom Verified 2.48265490285665 0.00652036776236362 no 139 0.00424056281690813 48 NA FT TRANSCRIPTION FROM RNA POL II|OXIDATION-REDUCTION PROCESS|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding carbon catabolite activation of transcription from RNA polymerase II promoter|regulation of cellular respiration RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription CCAAT-binding factor complex|nucleus
YKR073C_d YKR073C YKR073C hom Dubious 2.47551759431524 0.00665216031354783 no 140 0.0110821588090791 162 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YJR005C-A_p YJR005C-A YJR005C-A hom Uncharacterized 2.45901623776681 0.00696591581948252 no 141 0.00486156046552165 60 NA Putative protein of unknown function; originally identified as a syntenic homolog of an Ashbya gossypii gene; YJR005C-A has a paralog, YGR169C-A, that arose from the whole genome duplication biological_process molecular_function cellular_component
YGR130C YGR130C YGR130C hom Verified 2.45887635916421 0.00696863037423275 no 142 0.0123458710797715 114 NA Component of the eisosome with unknown function; GFP-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7) biological_process molecular_function eisosome|membrane raft|cytoplasm
YGL043W YGL043W DST1 hom Verified 2.4469756667036 0.00720302823382449 no 143 0.006942039508584 113 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION NUCLEUS General transcription elongation factor TFIIS, enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites; maintains RNAPII elongation activity on ribosomal protein genes during conditions of transcriptional stress transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|mRNA cleavage|maintenance of transcriptional fidelity during DNA-dependent transcription elongation from RNA polymerase II promoter|tRNA transcription from RNA polymerase III promoter|regulation of mRNA 3'-end processing|positive regulation of transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|transcription antitermination|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter RNA polymerase II regulatory region DNA binding|RNA polymerase II core binding|core RNA polymerase II recruiting transcription factor activity nucleus
YOR199W_d YOR199W YOR199W hom Dubious 2.44674256801025 0.00720768799244432 no 144 0.011427796871276 77 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDL041W_d YDL041W YDL041W hom Dubious 2.44352031852571 0.00727237528169886 no 145 0.0171476927670434 175 NA FF Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIR2/YDL042C Unknown Unknown Unknown
YIL066C YIL066C RNR3 hom Verified 2.44071749771458 0.00732905816778684 no 146 0.00527258917971955 103 NA FT OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM MITOCHONDRION Minor isoform of the large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits deoxyribonucleotide biosynthetic process ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor mitochondrion|ribonucleoside-diphosphate reductase complex|cytoplasm
YEL056W YEL056W HAT2 hom Verified 2.43187772613589 0.0075103885756878 no 147 0.00385683847147419 49 NA FT CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING NUCLEUS HISTONE ACETYLTRANSFERASE Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing histone acetylation|chromatin assembly or disassembly|chromatin silencing at telomere histone acetyltransferase activity|histone binding histone acetyltransferase complex|nucleus|cytoplasm
YEL037C YEL037C RAD23 hom Verified 2.41998014435171 0.00776067729446341 no 148 0.00784059438760787 68 NA FT RESPONSE TO DNA DAMAGE|PROTEOLYSIS NUCLEUS|MITOCHONDRION Protein with ubiquitin-like N terminus, subunit of Nuclear Excision Repair Factor 2 (NEF2) with Rad4p that binds damaged DNA; enhances protein deglycosylation activity of Png1p; also involved, with Rad4p, in ubiquitylated protein turnover proteasomal ubiquitin-dependent protein catabolic process|nucleotide-excision repair, DNA damage recognition|ER-associated protein catabolic process|protein deglycosylation damaged DNA binding|ubiquitin binding|peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity|protein binding, bridging proteasome complex|mitochondrion|nucleotide-excision repair factor 2 complex
YLR073C YLR073C RFU1 hom Verified 2.41960336676188 0.00776872205079134 no 149 0.0121043762779369 103 NA Protein that inhibits Doa4p deubiquitinating activity; contributes to ubiquitin homeostasis by regulating the conversion of free ubiquitin chains to ubiquitin monomers by Doa4p; GFP-fusion protein localizes to endosomes regulation of ubiquitin homeostasis enzyme inhibitor activity endosome
YOR135C_d YOR135C IRC14 hom Dubious 2.40778233876865 0.0080248733362444 no 150 0.00493151997520246 83 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YOR136W; null mutant displays increased levels of spontaneous Rad52 foci Unknown Unknown Unknown
YDR471W YDR471W RPL27B hom Verified 2.406480990311 0.00805352113651538 no 151 0.00732436965262752 64 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L27B; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27B has a paralog, RPL27A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YBR069C YBR069C TAT1 hom Verified 2.40364893550099 0.0081161766784581 no 152 0.109518460485692 442 NA FF|FT PLASMA MEMBRANE Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress amino acid transport|tyrosine transport|tryptophan transport|transmembrane transport amino acid transmembrane transporter activity|low-affinity tryptophan transmembrane transporter activity integral to membrane|plasma membrane
YGR129W YGR129W SYF2 hom Verified 2.38748632165916 0.00848201700790661 no 153 0.0137414321898755 103 NA FT RNA PROCESSING NUCLEUS Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; isy1 syf2 cells have defective spindles activiating cell cycle arrest mRNA splicing, via spliceosome first spliceosomal transesterification activity|second spliceosomal transesterification activity U2-type post-mRNA release spliceosomal complex|Prp19 complex|U2-type prespliceosome|U2-type catalytic step 2 spliceosome|U2-type catalytic step 1 spliceosome
YBL061C YBL061C SKT5 hom Verified 2.38456721063908 0.00854961211988555 no 154 0.0116058314460421 147 NA FT CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON Activator of Chs3p (chitin synthase III) during vegetative growth; recruits Chs3p to the bud neck via interaction with Bni4p; SKT5 has a paralog, SHC1, that arose from the whole genome duplication fungal-type cell wall chitin biosynthetic process|response to osmotic stress|cytokinesis enzyme activator activity incipient cellular bud site|cellular bud neck septin ring|cellular bud neck
YPL239W YPL239W YAR1 hom Verified 2.38097577610998 0.00863342368259666 no 155 0.0102332698571848 113 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RESPONSE TO OXIDATIVE STRESS Ankyrin-repeat containing, nucleocytoplasmic shuttling chaperone; prevents aggregation of Rps3p in the cytoplasm, associates with free Rps3p in the cytoplasm and delivers it to the 90S in the nucleus; required for 40S ribosomal subunit export, biogenesis and adaptation to osmotic and oxidative stress; expression repressed by heat shock ribosomal small subunit biogenesis|cellular response to oxidative stress|response to osmotic stress molecular_function cytoplasm
YDR386W YDR386W MUS81 hom Verified 2.37521962355247 0.0087692555878527 no 156 0.0173171122514789 130 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p DNA repair|DNA topological change|reciprocal meiotic recombination|resolution of meiotic recombination intermediates|response to DNA damage stimulus crossover junction endodeoxyribonuclease activity|endonuclease activity Holliday junction resolvase complex|nucleus
YGR249W YGR249W MGA1 hom Verified 2.36390219575818 0.00904179295778091 no 157 0.010381263820928 100 NA FT NUCLEUS Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants filamentous growth sequence-specific DNA binding|DNA binding|sequence-specific DNA binding transcription factor activity nucleus
YMR222C YMR222C FSH2 hom Verified 2.34727989977117 0.00945552124466746 no 158 0.00672882217113125 73 NA Putative serine hydrolase that localizes to the cytoplasm; sequence is similar to S. cerevisiae Fsh1p and Fsh3p and the human candidate tumor suppressor OVCA2 biological_process molecular_function cytoplasm
YOR014W YOR014W RTS1 hom Verified 2.34258153968064 0.00957542439955258 no 159 0.0214968324636906 186 NA FT PROTEIN LOCALIZATION|CELL CYCLE|SIGNALING|CHROMOSOME SEGREGATION NUCLEUS|SITE OF POLARIZED GROWTH|CHROMOSOME|CYTOSKELETON B-type regulatory subunit of protein phosphatase 2A (PP2A); Rts1p and Cdc55p are alternative regulatory subunits for PP2A catalytic subunits, Pph21p and Pph22p; PP2A-Rts1p protects cohesin when recruited by Sgo1p to the pericentromere; highly enriched at centromeres in the absence of Cdc55p; required for maintenance of septin ring organization during cytokinesis, for ring disassembly in G1 and for dephosphorylation of septin, Shs1p; homolog of the mammalian B' subunit of PP2A mitotic cell cycle spindle orientation checkpoint|cellular protein localization|meiotic sister chromatid cohesion, centromeric|protein dephosphorylation protein serine/threonine phosphatase activity nucleus|spindle pole body|condensed nuclear chromosome, centromeric region|cellular bud neck|cytoplasm
YNL314W YNL314W DAL82 hom Verified 2.34227446432431 0.00958330709722864 no 160 0.00759479089711465 125 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS NUCLEUS Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain allantoin catabolic process|nitrogen catabolite activation of transcription from RNA polymerase II promoter sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nucleus
YOL051W YOL051W GAL11 hom Verified 2.3344218877439 0.00978682090082725 no 161 0.0360779429080291 247 NA FF|FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors; forms part of the tail domain of mediator negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly|TFIIE-class binding transcription factor activity|RNA polymerase II activating transcription factor binding|TFIIE-class transcription factor binding|TFIIH-class transcription factor binding|RNA polymerase II transcription factor recruiting transcription factor activity core mediator complex
YDL074C YDL074C BRE1 hom Verified 2.32443196790324 0.0100511769362773 no 162 0.0369360357052388 172 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING NUCLEUS|CHROMOSOME E3 ubiquitin ligase, forms heterodimer with Rad6p to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR, transcription, silencing, and checkpoint control mitotic cell cycle G1/S transition DNA damage checkpoint|intra-S DNA damage checkpoint|meiotic DNA double-strand break formation|histone monoubiquitination|double-strand break repair via homologous recombination|transcription from RNA polymerase II promoter|chromatin silencing at telomere ubiquitin-protein ligase activity nuclear chromatin
YCL036W YCL036W GFD2 hom Verified 2.32215325656236 0.0101123424480788 no 163 0.00988076570591767 109 NA Protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; GFD2 has a paralog, YDR514C, that arose from the whole genome duplication biological_process molecular_function cellular_component
YAL008W YAL008W FUN14 hom Verified 2.32040215754748 0.0101595661444863 no 164 0.0160963674498925 94 NA FT MITOCHONDRION Mitochondrial protein of unknown function biological_process molecular_function mitochondrial outer membrane|mitochondrion
YGL084C YGL084C GUP1 hom Verified 2.31737462544573 0.0102416666793461 no 165 0.0533253189686544 324 NA FF|FT LIPID METABOLISM|CARBOHYDRATE METABOLISM ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; proposed to be involved in glycerol transport GPI anchor biosynthetic process|glycerol transport|glycerol catabolic process O-acyltransferase activity integral to membrane|endoplasmic reticulum|plasma membrane|membrane
YOR221C YOR221C MCT1 hom Verified 2.31004852239324 0.0104427339613384 no 166 0.0186520400325492 155 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Predicted malonyl-CoA:ACP transferase, putative component of a type-II mitochondrial fatty acid synthase that produces intermediates for phospholipid remodeling fatty acid metabolic process|aerobic respiration [acyl-carrier-protein] S-malonyltransferase activity mitochondrion
YBR103W YBR103W SIF2 hom Verified 2.30809472180678 0.010496934348476 no 167 0.0131508879162583 142 NA FT CELL CYCLE|CHROMATIN ORGANIZATION|SIGNALING|GENE SILENCING NUCLEUS|CHROMOSOME WD40 repeat-containing subunit of the Set3C histone deacetylase complex, which represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus negative regulation of meiosis|negative regulation of chromatin silencing at telomere|regulation of transcription, DNA-dependent|histone deacetylation|positive regulation of stress-activated MAPK cascade molecular_function Rpd3L-Expanded complex|nucleus|Set3 complex
YER139C YER139C RTR1 hom Verified 2.30210846963165 0.0106645279548367 no 168 0.0105455947580189 122 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS CTD phosphatase; dephosphorylates S5-P in the C-terminal domain of Rpo21p; has a cysteine-rich motif required for function and conserved in eukaryotes; shuttles between the nucleus and cytoplasm; RTR1 has a paralog, RTR2, that arose from the whole genome duplication dephosphorylation of RNA polymerase II C-terminal domain|transcription from RNA polymerase II promoter CTD phosphatase activity nucleus|cytoplasm
YGR288W YGR288W MAL13 hom Verified 2.29989962074633 0.0107269537968399 no 169 0.00928931631107604 121 NA FT TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM NUCLEUS MAL-activator protein, part of complex locus MAL1; nonfunctional in genomic reference strain S288C cellular carbohydrate metabolic process|regulation of transcription, DNA-dependent sequence-specific DNA binding transcription factor activity nucleus
YER180C-A YER180C-A SLO1 hom Verified 2.29506234736358 0.0108647757547835 no 170 0.0163138802212383 159 NA FT PROTEIN LOCALIZATION Protein interacting with Arl3p, which is a GTPase of the Ras superfamily involved in vesicle-tethering at the Golgi; putative ortholog of human SCOCO intracellular protein transport small GTPase regulator activity cytoplasm
YJL083W YJL083W TAX4 hom Verified 2.28730320223696 0.0110890658576365 no 171 0.00622466423044711 58 NA FT LIPID METABOLISM|SIGNALING|CELL WALL ORG/BIOGENESIS|RESPONSE TO NUTRIENT LEVELS EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; TAX4 has a paralog, IRS4, that arose from the whole genome duplication autophagy|fungal-type cell wall organization|inositol lipid-mediated signaling|CVT pathway|cellular response to starvation molecular_function pre-autophagosomal structure
YKR095W YKR095W MLP1 hom Verified 2.28526730718099 0.011148579340879 no 172 0.00800025863385558 88 NA FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|CYTOSKELETON Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs protein localization to nuclear pore|poly(A)+ mRNA export from nucleus|protein import into nucleus|transcriptional activation by promoter-terminator looping|nuclear retention of unspliced pre-mRNA at the site of transcription|telomere tethering at nuclear periphery ribonucleoprotein complex binding nucleoplasm|nuclear envelope|integral to membrane|ribonucleoprotein complex|spindle pole body
YCL055W YCL055W KAR4 hom Verified 2.2846924368778 0.0111654342081317 no 173 0.00916234393872769 97 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE NUCLEUS Transcription factor required for gene regulation in response to pheromones; also required during meiosis; exists in two forms, a slower-migrating form more abundant during vegetative growth and a faster-migrating form induced by pheromone karyogamy involved in conjugation with cellular fusion|meiosis|negative regulation of transcription from RNA polymerase II promoter by pheromones|positive regulation of transcription from RNA polymerase II promoter by pheromones|G1 phase of mitotic cell cycle sequence-specific DNA binding transcription factor activity nucleus|cytoplasm
YNR037C YNR037C RSM19 hom Verified 2.27795333803717 0.0113646789357607 no 174 0.0187337494574725 127 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S19 ribosomal protein mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YDL056W YDL056W MBP1 hom Verified 2.27687258632841 0.0113969176770512 no 175 0.0185019734088502 164 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE NUCLEUS Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes positive regulation of transcription involved in G1/S phase of mitotic cell cycle sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription MBF transcription complex|nucleus
YML009W-B_d YML009W-B YML009W-B hom Dubious 2.2723361743624 0.0115331067503178 no 176 0.0122198544968787 122 NA Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition Unknown Unknown Unknown
YER131W YER131W RPS26B hom Verified 2.26751478180921 0.011679398472835 no 177 0.0128212912112126 100 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S26, no bacterial homolog; RPS26B has a paralog, RPS26A, that arose from the whole genome duplication cytoplasmic translation|rRNA export from nucleus structural constituent of ribosome cytosolic small ribosomal subunit
YNR074C YNR074C AIF1 hom Verified 2.26231285254232 0.011839040451108 no 178 0.0120037751285673 92 NA FT OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS NUCLEUS|MITOCHONDRION|PLASMA MEMBRANE Mitochondrial cell death effector that translocates to the nucleus in response to apoptotic stimuli, homolog of mammalian Apoptosis-Inducing Factor, putative reductase response to singlet oxygen|positive regulation of apoptotic process oxidoreductase activity, acting on a sulfur group of donors, NAD or NADP as acceptor mitochondrion|nucleus|plasma membrane
YOR045W YOR045W TOM6 hom Verified 2.24361225695386 0.012428679973297 no 179 0.0108080190267034 107 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex mitochondrial outer membrane translocase complex assembly|protein import into mitochondrial matrix protein channel activity mitochondrion|integral to membrane|mitochondrial outer membrane translocase complex
YJL199C_d YJL199C MBB1 hom Dubious 2.24316895908575 0.0124429605840003 no 180 0.0111191723869186 78 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; protein detected in large-scale protein-protein interaction studies Unknown Unknown Unknown
YMR255W YMR255W GFD1 hom Verified 2.23971047518241 0.0125548625364492 no 181 0.0100470669100626 100 NA FT PROTEIN LOCALIZATION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE Coiled-coiled protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; protein abundance increases in response to DNA replication stress mRNA export from nucleus molecular_function integral to membrane|nuclear pore|cytoplasm
YNL072W YNL072W RNH201 hom Verified 2.23804365069189 0.0126091043605047 no 182 0.0410263520672269 221 NA FT NUCLEUS Ribonuclease H2 catalytic subunit, removes RNA primers during Okazaki fragment synthesis and errant ribonucleotides misincorporated during DNA replication; homolog of RNAse HI; related to human AGS4 which causes Aicardi-Goutieres syndrome DNA replication, removal of RNA primer ribonuclease H activity ribonuclease H2 complex|nucleus
YDL194W YDL194W SNF3 hom Verified 2.2261917685876 0.0130006695449746 no 183 0.0105169477463373 107 NA FT CELL CYCLE|SIGNALING PLASMA MEMBRANE Plasma membrane low glucose sensor, regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; also senses fructose and mannose; SNF3 has a paralog, RGT2, that arose from the whole genome duplication mannose transport|glucose transport|signal transduction|negative regulation of meiosis|detection of glucose|fructose transport glucose transmembrane transporter activity|receptor activity|glucose binding integral to membrane|plasma membrane
YCR034W YCR034W FEN1 hom Verified 2.22597472081275 0.0130079373596996 no 184 0.0306703757079348 239 NA FF|FT VESICLE-MEDIATED TRANSPORT|KETONE METABOLISM|LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway; FEN1 has a paralog, ELO1, that arose from the whole genome duplication fatty acid elongation|vesicle-mediated transport|sphingolipid biosynthetic process fatty acid elongase activity integral to membrane|endoplasmic reticulum|endoplasmic reticulum membrane
YER046W-A_d YER046W-A YER046W-A hom Dubious 2.22351386585395 0.0130905847287024 no 185 0.00975347411229477 78 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOL004W YOL004W SIN3 hom Verified 2.22209169137463 0.0131385548337505 no 186 0.0129091675437361 154 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CELL DIVISION|GENE SILENCING NUCLEUS|CHROMOSOME Component of the Sin3p-Rpd3p histone deacetylase complex, involved in transcriptional repression and activation of diverse processes, including mating-type switching and meiosis; involved in the maintenance of chromosomal integrity positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of chromatin silencing at rDNA|histone deacetylation|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of transcription from RNA polymerase I promoter|negative regulation of transcription during meiosis|regulation of DNA-dependent DNA replication initiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of chromatin silencing at telomere|double-strand break repair via nonhomologous end joining|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription involved in G2/M-phase of mitotic cell cycle transcription coactivator activity|transcription corepressor activity Sin3-type complex|Rpd3S complex|Rpd3L-Expanded complex|Rpd3L complex
YGR139W_d YGR139W YGR139W hom Dubious 2.21742194589617 0.0132971357088234 no 187 0.00592860000453634 73 NA Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YHR046C YHR046C INM1 hom Verified 2.21654809931615 0.0133269937777362 no 188 0.0178686464419514 127 NA FT LIPID METABOLISM|CARBOHYDRATE METABOLISM NUCLEUS Inositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate inositol phosphate dephosphorylation inositol monophosphate 1-phosphatase activity nucleus|cytoplasm
YBR061C YBR061C TRM7 hom Verified 2.21249238252539 0.0134663309801349 no 189 0.0125766777288951 153 NA FT RNA PROCESSING|TRANSLATION 2'-O-ribose methyltransferase; methylates the 2'-O-ribose of tRNA-Phe, tRNA-Trp, and tRNA-Leu at positions C32 and N34 of the tRNA anticodon loop; crucial biological role likely modification of tRNA-Phe; interacts with Trm732p and Rtt10p in 2'-O-methylation of C32 and N34 substrate tRNAs, respectively cytoplasmic translation|tRNA methylation tRNA methyltransferase activity cytoplasm
YNL197C YNL197C WHI3 hom Verified 2.20566377053985 0.0137037752018429 no 190 0.0153876703727618 150 NA FT PROTEIN LOCALIZATION|CELL CYCLE RNA binding protein that sequesters CLN3 mRNA in cytoplasmic foci;; Tpk1 (PKA) mediated phosphorylation of Whi3 affects G1/S transition by modulating Cln3 transcription; cytoplasmic retention factor for Cdc28p and associated cyclins; regulates cell fate and dose-dependently regulates the critical cell size required for passage through Start; WHI3 has a paralog, WHI4, that arose from the whole genome duplication pseudohyphal growth|invasive growth in response to glucose limitation|regulation of cell size|cytoplasmic sequestering of protein RNA binding cytoplasm
YHL033C YHL033C RPL8A hom Verified 2.2051268967566 0.0137225955804407 no 191 0.0188489849246378 126 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal 60S subunit protein L8A; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8A has a paralog, RPL8B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YPR196W_p YPR196W YPR196W hom Uncharacterized 2.20152471076429 0.0138494496557239 no 192 0.0114060470707238 123 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Putative maltose-responsive transcription factor regulation of transcription, DNA-dependent sequence-specific DNA binding cellular_component
YJR014W YJR014W TMA22 hom Verified 2.19893751957186 0.0139411826519479 no 193 0.00369859913275462 59 NA FT TRANSLATION RIBOSOME Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1; protein abundance increases in response to DNA replication stress biological_process RNA binding ribosome|cytoplasm
YHR011W YHR011W DIA4 hom Verified 2.19846707749123 0.0139579190932017 no 194 0.0217145554390602 181 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Probable mitochondrial seryl-tRNA synthetase, mutant displays increased invasive and pseudohyphal growth pseudohyphal growth|invasive growth in response to glucose limitation|mitochondrial seryl-tRNA aminoacylation serine-tRNA ligase activity mitochondrion|cytoplasm
YAR035C-A_p YAR035C-A YAR035C-A hom Uncharacterized 2.18909628939399 0.0142949210913447 no 195 0.00882415295645532 122 NA Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; predicted to have a role in cell budding based on computational guilt by association analysis biological_process molecular_function cellular_component
YKR082W YKR082W NUP133 hom Verified 2.17696871272387 0.0147414509608232 no 196 0.0168306326609231 131 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP133 poly(A)+ mRNA export from nucleus|double-strand break repair|maintenance of chromatin silencing at telomere|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|tRNA export from nucleus|telomere tethering at nuclear periphery|nuclear pore distribution|mRNA export from nucleus in response to heat stress|positive regulation of transcription, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette structural constituent of nuclear pore integral to membrane|nuclear pore|nuclear pore outer ring
YBR058C-A YBR058C-A TSC3 hom Verified 2.17390764217771 0.0148560360034367 no 197 0.124208015872836 658 NA FF|FT KETONE METABOLISM|LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis 3-keto-sphinganine metabolic process|sphingolipid biosynthetic process enzyme activator activity SPOTS complex
YJR144W YJR144W MGM101 hom Verified 2.1663952112307 0.0151404997934284 no 198 0.0270874818128286 190 NA FT RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION MITOCHONDRION|CHROMOSOME Protein with a role in mitochondrial DNA recombinational repair;also involved in interstrand cross-link repair; binds to and catalyzes the annealing of single-stranded mtDNA; oligomerizes to form rings and filaments; related to Rad52-type recombination proteins, with limited overall similarity but sharing conserved functionally important residues; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage DNA repair|recombinational repair|DNA strand renaturation molecular_function mitochondrial nucleoid|mitochondrion
YMR175W YMR175W SIP18 hom Verified 2.1625034867762 0.0152896943111855 no 199 0.00882316011904977 86 NA Phospholipid-binding hydrophilin; essential to overcome desiccation-rehydration process; expression is induced by osmotic stress cellular response to water deprivation phospholipid binding cytoplasm
YBL053W_d YBL053W YBL053W hom Dubious 2.16068317781057 0.015359910622133 no 200 0.0127833850200128 110 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOL113W YOL113W SKM1 hom Verified 2.15905915934685 0.0154227887910279 no 201 0.0198134654041291 140 NA FT CELL DIVISION|PROTEIN PHOSPHORYLATION NUCLEUS|PLASMA MEMBRANE Member of the PAK family of serine/threonine protein kinases with similarity to Ste20p and Cla4p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth negative regulation of gene expression|cytokinetic cell separation|protein phosphorylation|sterol import protein serine/threonine kinase activity|protein kinase activity plasma membrane|nucleus
YOR038C YOR038C HIR2 hom Verified 2.15668032885351 0.0155152903658254 no 202 0.0126745865886271 110 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p DNA replication-independent nucleosome assembly|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter nucleosome binding|transcription corepressor activity|DNA binding HIR complex|nucleus
YDR136C_d YDR136C VPS61 hom Dubious 2.15606017919407 0.0155394831889523 no 203 0.0902107541873695 334 NA FF Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 4% of ORF overlaps the verified gene RGP1; deletion causes a vacuolar protein sorting defect Unknown Unknown Unknown
YPL144W YPL144W POC4 hom Verified 2.149808541901 0.0157851811255219 no 204 0.014126628168174 122 NA FT PROTEIN COMPLEX ORG/BIOGENESIS Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions proteasome assembly|chaperone-mediated protein complex assembly molecular_function intracellular|cytoplasm
YPL132W YPL132W COX11 hom Verified 2.14449267766657 0.0159967157570509 no 205 0.0208213670096058 113 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION RIBOSOME Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p protein complex assembly|aerobic respiration copper ion binding mitochondrial envelope|mitochondrion|mitochondrial ribosome|mitochondrial inner membrane
YML124C YML124C TUB3 hom Verified 2.14375232602515 0.0160263685453638 no 206 0.0572954217985838 358 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|NUCLEOTIDE METABOLISM|CHROMOSOME SEGREGATION NUCLEUS|CYTOSKELETON Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication nuclear migration along microtubule|nuclear migration involved in conjugation with cellular fusion|homologous chromosome segregation|mitotic sister chromatid segregation structural constituent of cytoskeleton tubulin complex|cytoplasmic microtubule|kinetochore microtubule|nuclear microtubule|spindle pole body|polar microtubule
YAL022C YAL022C FUN26 hom Verified 2.14065422810295 0.0161509661137354 no 207 0.0160523130854712 129 NA Vacuolar membrane transporter with broad nucleoside selectivity; may regulate balance of nicotinamide riboside (NmR) levels between cytosol and vacuole, contributing to salvage of NmR for use in cytosolic NAD+ synthesis nucleoside transport|nicotinamide riboside transport|transmembrane transport nicotinamide riboside transporter activity|nucleoside transmembrane transporter activity fungal-type vacuole membrane|integral to membrane|intracellular|membrane
YBR043C YBR043C QDR3 hom Verified 2.14018927409632 0.0161697368176685 no 208 0.0109329888184961 94 NA FT PLASMA MEMBRANE Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; has a role in polyamine homeostasis; expression is upregulated under polyamine stress; required for resistance to quinidine, barban, cisplatin, and bleomycin drug transmembrane transport|polyamine homeostasis drug transmembrane transporter activity|polyamine transmembrane transporter activity integral to membrane|plasma membrane
YMR032W YMR032W HOF1 hom Verified 2.12880179678481 0.0166353311084049 no 209 0.0175997483744892 217 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CELL DIVISION SITE OF POLARIZED GROWTH|CYTOSKELETON Bud neck-localized, SH3 domain-containing protein required for cytokinesis; is phosphorylated by Dbf2p; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p cytokinesis after mitosis|barrier septum assembly involved in cell cycle cytokinesis|response to DNA damage stimulus|cytokinesis cytoskeletal protein binding cellular bud neck contractile ring|cellular bud neck septin ring
YMR038C YMR038C CCS1 hom Verified 2.12813593213443 0.016662907446807 no 210 0.0546271082566649 319 NA FF|FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS NUCLEUS|MITOCHONDRION Copper chaperone for superoxide dismutase Sod1p; involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation; protein abundance increases in response to DNA replication stress intracellular copper ion transport superoxide dismutase copper chaperone activity cytosol|mitochondrial inner membrane|nucleus
YDR020C_p YDR020C DAS2 hom Uncharacterized 2.12529787424397 0.0167808827740923 no 211 0.0108380312746185 113 NA FT NUCLEOTIDE METABOLISM NUCLEUS Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases biological_process molecular_function nucleus|cytoplasm
YOL100W YOL100W PKH2 hom Verified 2.1241192359461 0.0168300871969247 no 212 0.0191886567018235 158 NA FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION NUCLEUS Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh1p regulation of nuclear-transcribed mRNA poly(A) tail shortening|protein phosphorylation|MAPK cascade involved in cell wall biogenesis|cytoplasmic mRNA processing body assembly protein kinase activity cell cortex|eisosome|nucleus
YNR014W_p YNR014W YNR014W hom Uncharacterized 2.11704975848514 0.0171278125092084 no 213 0.0240295493268698 120 NA Putative protein of unknown function; expression is cell-cycle regulated, Azf1p-dependent, and heat-inducible; YNR014W has a paralog, YMR206W, that arose from the whole genome duplication biological_process molecular_function cytoplasm
YHR179W YHR179W OYE2 hom Verified 2.11685872673825 0.0171359197166024 no 214 0.0165103089932905 185 NA FT OXIDATION-REDUCTION PROCESS NUCLEUS|MITOCHONDRION Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress apoptotic process NADPH dehydrogenase activity mitochondrion|nucleus|cytoplasm
YCR002C YCR002C CDC10 hom Verified 2.11387734625541 0.0172628722812914 no 215 0.0279357588045129 184 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Component of the septin ring, required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells; N-terminus interacts with phosphatidylinositol-4,5-bisphosphate; protein abundance increases under DNA damage stress sporulation|maintenance of cell polarity|exit from mitosis|cell cycle cytokinesis|septin ring assembly protein complex scaffold|structural molecule activity|GTP binding|GTPase activity|1-phosphatidylinositol binding spindle microtubule|ascospore-type prospore|septin complex|prospore membrane|mating projection base|meiotic spindle|septin filament array|cellular bud neck septin ring|mating projection tip
YFL007W YFL007W BLM10 hom Verified 2.11230437578944 0.0173301753920491 no 216 0.0165473534800704 141 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS NUCLEUS Proteasome activator; binds the core proteasome and stimulates proteasome-mediated protein degradation by inducing gate opening; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200 proteasome assembly|regulation of proteasomal protein catabolic process proteasome binding|peptidase activator activity proteasome core complex|proteasome complex|integral to membrane|nucleus
YGL224C YGL224C SDT1 hom Verified 2.10871681954879 0.0174845160716919 no 217 0.0153010658500881 141 NA Pyrimidine nucleotidase; overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II, as well as resistance to other pyrimidine derivatives pyrimidine nucleobase metabolic process nucleotidase activity cellular_component
YLR128W YLR128W DCN1 hom Verified 2.10788303157022 0.0175205541613881 no 218 0.0232583519912546 128 NA Scaffold-type E3 ligase required for cullin neddylation and ubiquitin ligase activation; contains a ubiquitin-binding domain (UBA) for ubiquitin and Nedd8 (Rub1p) interaction and a PONY domain involved in cullin binding and neddylation protein neddylation|positive regulation of ubiquitin-protein ligase activity ubiquitin binding|NEDD8 ligase activity|small conjugating protein binding cellular_component
YPR057W YPR057W BRR1 hom Verified 2.10664287810172 0.017574273524867 no 219 0.0116569300165153 127 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING NUCLEUS snRNP protein component of spliceosomal snRNPs, required for pre-mRNA splicing and snRNP biogenesis; in null mutant newly-synthesized snRNAs are destabilized and 3'-end processing is slowed spliceosomal complex assembly RNA binding small nuclear ribonucleoprotein complex
YER034W YER034W YER034W hom Verified 2.09324159346182 0.0181637967605666 no 220 0.0223807201832185 125 NA FT NUCLEUS Protein of unknown function; non-essential gene; expression induced upon calcium shortage; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus|cytoplasm
YOR002W YOR002W ALG6 hom Verified 2.05782664556818 0.0198033886459006 no 221 0.0429221769712902 257 NA FT LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Alpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease oligosaccharide-lipid intermediate biosynthetic process|protein glycosylation|aerobic respiration transferase activity, transferring hexosyl groups|dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity integral to membrane|endoplasmic reticulum
YHR067W YHR067W HTD2 hom Verified 2.05622976104895 0.0198801874547346 no 222 0.0369901797364023 239 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION Mitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology fatty acid biosynthetic process 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity mitochondrion
YGL115W YGL115W SNF4 hom Verified 2.04830173214516 0.020265221689802 no 223 0.0319108814689727 235 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|PLASMA MEMBRANE Activating gamma subunit of the AMP-activated Snf1p kinase complex; additional subunits of the complex are Snf1p and a Sip1p/Sip2p/Gal83p family member; activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis; protein abundance increases in response to DNA replication stress positive regulation of gluconeogenesis|peroxisome organization|protein phosphorylation|replicative cell aging|regulation of transcription from RNA polymerase II promoter AMP-activated protein kinase activity|protein serine/threonine kinase activator activity AMP-activated protein kinase complex|plasma membrane|nucleus|nuclear envelope lumen|cytoplasm
YGR146C-A_p YGR146C-A YGR146C-A hom Uncharacterized 2.03614759136485 0.02086776852291 no 224 0.0201105426083587 101 NA Putative protein of unknown function biological_process molecular_function cellular_component
YLR436C YLR436C ECM30 hom Verified 2.03182536743877 0.0210856690707214 no 225 0.0296389087811499 191 NA FT CELL WALL ORG/BIOGENESIS Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants have abormal relative levels of mannose and glucose and have Gap1p sorting and transport defects; (GFP)-fusion protein localizes to the cytoplasm fungal-type cell wall organization molecular_function cytoplasm
YMR326C_d YMR326C YMR326C hom Dubious 2.03069168974684 0.0211431399430244 no 226 0.0200320708369191 107 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the telomere on the right arm of chromosome 13 Unknown Unknown Unknown
YPL026C YPL026C SKS1 hom Verified 2.01801954755242 0.0217946127750191 no 227 0.00663298553320152 69 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN PHOSPHORYLATION NUCLEUS Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway glucose transport|protein phosphorylation|response to glucose stimulus|positive regulation of transcription from RNA polymerase II promoter protein serine/threonine kinase activity|protein kinase activity nucleus|cytoplasm
YDR337W YDR337W MRPS28 hom Verified 2.01531486061226 0.0219358344115332 no 228 0.0362419280490266 223 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit mitochondrial translation structural constituent of ribosome|RNA binding mitochondrion|mitochondrial small ribosomal subunit
YER090W YER090W TRP2 hom Verified 2.01434347624418 0.0219867421800858 no 229 0.210358297737455 808 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p tryptophan biosynthetic process anthranilate synthase activity anthranilate synthase complex|cytoplasm
YPL141C YPL141C FRK1 hom Verified 2.00607384261818 0.0224241850831475 no 230 0.0211448483657309 176 NA FT PROTEIN PHOSPHORYLATION Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; interacts with rRNA transcription and ribosome biogenesis factors and the long chain fatty acyl-CoA synthetase Faa3p; FRK1 has a paralog, KIN4, that arose from the whole genome duplication protein phosphorylation protein kinase activity cytoplasm
YCL027W YCL027W FUS1 hom Verified 2.00197207832957 0.0226438673020365 no 231 0.0105132153427037 65 NA FT PROTEIN LOCALIZATION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Membrane protein localized to the shmoo tip, required for cell fusion; expression regulated by mating pheromone; proposed to coordinate signaling, fusion, and polarization events required for fusion; potential Cdc28p substrate regulation of termination of mating projection growth|cytogamy|cortical protein anchoring molecular_function integral to plasma membrane|mating projection tip
YGR233C YGR233C PHO81 hom Verified 1.9997636367277 0.0227628964464009 no 232 0.0260363835615476 172 NA FT LIPID METABOLISM NUCLEUS Cyclin-dependent kinase (CDK) inhibitor; regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; inhibitory activity for Pho80p-Pho85p requires myo-D-inositol heptakisphosphate (IP7) generated by Vip1p; relative distribution to the nucleus increases upon DNA replication stress phosphate-containing compound metabolic process cyclin-dependent protein kinase inhibitor activity nucleus|cytoplasm
YLR214W YLR214W FRE1 hom Verified 1.99490081374883 0.0230268493815457 no 233 0.0155869062277293 90 NA FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY PLASMA MEMBRANE Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels iron ion transport|copper ion import ferric-chelate reductase activity integral to membrane|plasma membrane
YMR275C YMR275C BUL1 hom Verified 1.99292666762242 0.0231347388421599 no 234 0.0294161023195907 184 NA FT MITOCHONDRION ORGANIZATION PLASMA MEMBRANE UBIQUITIN LIGASE COMPLEX Ubiquitin-binding component of the Rsp5p E3-ubiquitin ligase complex; disruption causes temperature-sensitive growth, overexpression causes missorting of amino acid permeases; BUL1 has a paralog, BUL2, that arose from the whole genome duplication mitochondrion inheritance|protein monoubiquitination|protein polyubiquitination ubiquitin-ubiquitin ligase activity ubiquitin ligase complex|plasma membrane
YMR261C YMR261C TPS3 hom Verified 1.99212799683514 0.0231785079291103 no 235 0.0204641912780757 153 NA FT CARBOHYDRATE METABOLISM Regulatory subunit of trehalose-6-phosphate synthase/phosphatase; involved in synthesis of storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; TPS3 has a paralog, TSL1, that arose from the whole genome duplication trehalose biosynthetic process|response to stress enzyme regulator activity|alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity|trehalose-phosphatase activity alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
YGR252W YGR252W GCN5 hom Verified 1.98938658146625 0.023329274797608 no 236 0.0750172171483095 344 NA FF|FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME HISTONE ACETYLTRANSFERASE Acetyltransferase, modifies N-terminal lysines on histones H2B and H3; acetylates Rsc4p, a subunit of the RSC chromatin-remodeling complex, altering replication stress tolerance; catalytic subunit of the ADA and SAGA histone acetyltransferase complexes; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; greater involvement in repression of RNAPII-dependent transcription than in activation histone acetylation|regulation of transcription by chromatin organization|chromatin modification|positive regulation of transcription elongation from RNA polymerase II promoter histone acetyl-lysine binding|transcription coactivator activity|histone acetyltransferase activity|H3 histone acetyltransferase activity SLIK (SAGA-like) complex|chromosome, centromeric region|Ada2/Gcn5/Ada3 transcription activator complex|SAGA complex
YGR015C_p YGR015C YGR015C hom Uncharacterized 1.98829216316536 0.0233896935096447 no 237 0.0291286950068266 124 NA FT MITOCHONDRION Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion biological_process molecular_function mitochondrion
YER119C-A_d YER119C-A YER119C-A hom Dubious 1.98429516938273 0.0236114721937727 no 238 0.0462077598564065 286 NA FF Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene SCS2 Unknown Unknown Unknown
YCR075W-A_p YCR075W-A YCR075W-A hom Uncharacterized 1.9837692736328 0.0236407834780761 no 239 0.0247440556729863 164 NA Putative protein of unknown function; identified by homology to Ashbya gossypii; YCR075W-A has a paralog, YNR034W-A, that arose from the whole genome duplication biological_process molecular_function cellular_component
YER002W YER002W NOP16 hom Verified 1.97783779400877 0.0239735041811855 no 240 0.0314609873457587 135 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis ribosomal large subunit biogenesis molecular_function nucleolus|nucleus|preribosome, large subunit precursor
YPL006W YPL006W NCR1 hom Verified 1.95951446608806 0.0250262837132211 no 241 0.0252079948894803 164 NA FT LIPID METABOLISM Vacuolar membrane protein that transits through the biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism; glycoprotein and functional orthologue of human Niemann Pick C1 (NPC1) protein sphingolipid metabolic process sphingolipid transporter activity fungal-type vacuole membrane|integral to membrane
YOL115W YOL115W PAP2 hom Verified 1.9585855662149 0.0250806706525835 no 242 0.0314619896102115 210 NA FT CELL CYCLE|RNA PROCESSING|RESPONSE TO DNA DAMAGE|CELL DIVISION NUCLEUS Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Trf5p polyadenylation-dependent mRNA catabolic process|nuclear polyadenylation-dependent CUT catabolic process|base-excision repair|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent snRNA catabolic process|ncRNA polyadenylation|histone mRNA catabolic process|nuclear polyadenylation-dependent mRNA catabolic process|nuclear polyadenylation-dependent antisense transcript catabolic process|U4 snRNA 3'-end processing|nuclear mRNA surveillance of mRNA 3'-end processing|polyadenylation-dependent snoRNA 3'-end processing|snoRNA polyadenylation|tRNA modification 5'-deoxyribose-5-phosphate lyase activity|polynucleotide adenylyltransferase activity nucleolus|nucleus|TRAMP complex
YBR204C YBR204C LDH1 hom Verified 1.95662839462777 0.0251955870650701 no 243 0.0215730340512946 118 NA FT LIPID METABOLISM Serine hydrolase; exhibits active esterase plus weak triacylglycerol lipase activities; proposed role in lipid homeostasis, regulating phospholipid and non-polar lipid levels and required for mobilization of LD-stored lipids; localizes to the lipid droplet (LD) surface; contains a classical serine containing catalytic triad (GxSxG motif) lipid homeostasis hydrolase activity, acting on ester bonds|serine hydrolase activity|triglyceride lipase activity lipid particle
YOR120W YOR120W GCY1 hom Verified 1.95661101871621 0.0251966092740814 no 244 0.0457767686031862 207 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS NUCLEUS Glycerol dehydrogenase;involved in an alternative pathway for glycerol catabolism used under microaerobic conditions; also has mRNA binding activity; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress; GCY1 has a paralog, YPR1, that arose from the whole genome duplication cellular response to oxidative stress|arabinose catabolic process|D-xylose catabolic process oxidoreductase activity|mRNA binding|alditol:NADP+ 1-oxidoreductase activity|aldo-keto reductase (NADP) activity nucleus|cytoplasm
YCR024C YCR024C SLM5 hom Verified 1.95647780724858 0.0252044471376765 no 245 0.0408391985535249 246 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial asparaginyl-tRNA synthetase asparaginyl-tRNA aminoacylation|mitochondrial asparaginyl-tRNA aminoacylation asparagine-tRNA ligase activity mitochondrion
YNL246W YNL246W VPS75 hom Verified 1.9538574814019 0.0253590370638746 no 246 0.0365040380058276 239 NA FT PROTEIN LOCALIZATION|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME NAP family histone chaperone; binds to histones and Rtt109p, stimulating histone acetyltransferase activity; possesses nucleosome assembly activity in vitro; proposed role in vacuolar protein sorting and in double-strand break repair; protein abundance increases in response to DNA replication stress double-strand break repair via nonhomologous end joining|nucleosome assembly|positive regulation of histone acetylation histone binding|acetyltransferase activator activity chromatin|nucleus
YPR018W YPR018W RLF2 hom Verified 1.95178805588998 0.0254816864668808 no 247 0.0236278130839894 162 NA FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1); chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription DNA replication-dependent nucleosome assembly histone binding chromosome, centromeric region|nucleus|CAF-1 complex
YOL111C YOL111C MDY2 hom Verified 1.94601430151342 0.0258265108562494 no 248 0.0417097338115909 231 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION NUCLEUS Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Get4p; required for efficient mating; involved in shmoo formation and nuclear migration in the pre-zygote; associates with ribosomes protein insertion into ER membrane|cell morphogenesis involved in conjugation with cellular fusion|posttranslational protein targeting to membrane molecular_function ribosome|TRC complex|nucleus|cytoplasm
YHL017W_p YHL017W YHL017W hom Uncharacterized 1.94556751568962 0.0258533561277746 no 249 0.0161926079142845 111 NA FT GOLGI APPARATUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein co-localizes with clathrin-coated vesicles; YHL017W has a paralog, PTM1, that arose from the whole genome duplication biological_process molecular_function integral to membrane|clathrin-coated vesicle
YPR198W YPR198W SGE1 hom Verified 1.93906517726707 0.0262467011338492 no 250 0.0557794240153722 335 NA FF|FT PLASMA MEMBRANE Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations response to drug|drug transport drug transmembrane transporter activity integral to membrane|integral to plasma membrane
YHR092C YHR092C HXT4 hom Verified 1.93026495594318 0.0267870084103736 no 251 0.0167310078800023 126 NA FT PLASMA MEMBRANE High-affinity glucose transporter; member of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose; HXT4 has a paralog, HXT7, that arose from the whole genome duplication hexose transport pentose transmembrane transporter activity|mannose transmembrane transporter activity|glucose transmembrane transporter activity|fructose transmembrane transporter activity integral to membrane|plasma membrane
YLR231C YLR231C BNA5 hom Verified 1.92656176091123 0.0270171340060386 no 252 0.0160236229998629 116 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM NUCLEUS Kynureninase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p de novo NAD biosynthetic process from tryptophan kynureninase activity nucleus|cytoplasm
YDR442W_d YDR442W YDR442W hom Dubious 1.92460691445045 0.0271392768619561 no 253 0.0458849598355825 202 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDR233C YDR233C RTN1 hom Verified 1.91776911741197 0.0275701466382266 no 254 0.0177517414249526 120 NA FT PROTEIN COMPLEX ORG/BIOGENESIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS Reticulon protein; stabilizes membrane curvature; involved in nuclear pore assembly and maintenance of tubular ER morphology; mutant overexpressing RTN1 shows increase in tubular ER; interacts with exocyst subunit Sec6p, Yip3p, and Sbh1p; more abundant than Rtn2p; member of the RTNLA subfamily; mutants have reduced phosphatidylserine transfer between the ER and mitochondria; RTN1 has a paralog, RTN2, that arose from the whole genome duplication endoplasmic reticulum tubular network organization|endoplasmic reticulum organization|endoplasmic reticulum tubular network maintenance|nuclear pore complex assembly molecular_function integral to endoplasmic reticulum membrane|mitochondrion|Golgi apparatus|endoplasmic reticulum|cortical endoplasmic reticulum|endoplasmic reticulum tubular network
YOL017W YOL017W ESC8 hom Verified 1.91527410943538 0.0277287778075805 no 255 0.0258675248433464 144 NA FT GENE SILENCING NUCLEUS Protein involved in telomeric and mating-type locus silencing; interacts with Sir2p and also interacts with Gal11p, which is a component of the RNA pol II mediator complex; ESC8 has a paralog, IOC3, that arose from the whole genome duplication chromatin silencing molecular_function nucleus
YNL203C_d YNL203C YNL203C hom Dubious 1.913241552744 0.0278585681161258 no 256 0.0304547896453965 217 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YER032W YER032W FIR1 hom Verified 1.91095929598024 0.0280049059775943 no 257 0.036040506381658 188 NA FT RNA PROCESSING SITE OF POLARIZED GROWTH Protein involved in 3' mRNA processing, interacts with Ref2p; potential Cdc28p substrate mRNA polyadenylation|RNA polyadenylation molecular_function cellular bud neck
YOL042W YOL042W NGL1 hom Verified 1.9094720658141 0.0281006109693163 no 258 0.024164108944828 120 NA FT MITOCHONDRION Putative endonuclease, has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process endonuclease activity mitochondrion
YDR453C YDR453C TSA2 hom Verified 1.90856819280868 0.0281589091857243 no 259 0.0186937863536479 121 NA FT OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants; protein abundance increases in response to DNA replication stress cellular response to oxidative stress|cell redox homeostasis peroxiredoxin activity|thioredoxin peroxidase activity cytoplasm
YDR125C YDR125C ECM18 hom Verified 1.90793750314804 0.0281996471713413 no 260 0.046881449601888 202 NA FT CELL WALL ORG/BIOGENESIS MITOCHONDRION Protein of unknown function; ECM18 has a paralog, ICT1, that arose from the whole genome duplication fungal-type cell wall organization molecular_function mitochondrion
YKL037W YKL037W AIM26 hom Verified 1.90285502084386 0.0285297327348615 no 261 0.0506454973259448 322 NA FF|FT MITOCHONDRION Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT mitochondrion degradation molecular_function mitochondrion|integral to membrane
YER119C YER119C AVT6 hom Verified 1.8972605689946 0.0288967781924832 no 262 0.0211121659516463 171 NA FT VACUOLAR TRANSPORT Vacuolar aspartate and glutamate exporter; member of a family of seven genes (AVT1-7) related to vesicular GABA-glycine transporters; involved in compartmentalizing acidic amino acids in response to nitrogen starvation; AVT6 has a paralog, AVT5, that arose from the whole genome duplication amino acid export from vacuole|transmembrane transport L-aspartate transmembrane transporter activity|transporter activity|L-glutamate transmembrane transporter activity fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YMR103C_d YMR103C YMR103C hom Dubious 1.89048878053971 0.0293463098465445 no 263 0.0314333171707528 140 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YNL020C YNL020C ARK1 hom Verified 1.89004125979908 0.0293762210602216 no 264 0.0217691478883725 145 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION SITE OF POLARIZED GROWTH|CYTOSKELETON Serine/threonine protein kinase; involved in regulation of the cortical actin cytoskeleton; involved in control of endocytosis; ARK1 has a paralog, PRK1, that arose from the whole genome duplication regulation of endocytosis|actin filament organization|protein phosphorylation|cytokinesis|actin cortical patch assembly protein serine/threonine kinase activity|protein kinase activity mating projection tip|actin cortical patch
YCL028W YCL028W RNQ1 hom Verified 1.88702483893734 0.0295784924203675 no 265 0.0207393928834362 146 NA FT NUCLEUS [PIN(+)] prion, an infectious protein conformation that is generally an ordered protein aggregate biological_process molecular_function cytosol
YOR317W YOR317W FAA1 hom Verified 1.88554236013897 0.0296783255033906 no 266 0.0309401566292005 204 NA FT KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM MITOCHONDRION Long chain fatty acyl-CoA synthetase; activates imported fatty acids with a preference for C12:0-C16:0 chain lengths; functions in long chain fatty acid import; accounts for most acyl-CoA synthetase activity; localized to lipid particles; involved in sphingolipid-to-glycerolipid metabolism; forms ER foci upon DNA replication stress; FAA1 has a paralog, FAA4, that arose from the whole genome duplication long-chain fatty acid transport|long-chain fatty-acyl-CoA metabolic process long-chain fatty acid-CoA ligase activity mitochondrial outer membrane|mitochondrion|lipid particle|plasma membrane
YMR106C YMR106C YKU80 hom Verified 1.88474503263878 0.0297321346609202 no 267 0.0218799759079398 159 NA FT PROTEIN LOCALIZATION|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING NUCLEUS|CHROMOSOME Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair chromatin assembly or disassembly|protein localization to chromosome|chromatin silencing|double-strand break repair via nonhomologous end joining|donor selection|telomere maintenance|double-strand break repair via homologous recombination damaged DNA binding|RNA binding|DNA binding|telomeric DNA binding nuclear chromatin|nuclear telomeric heterochromatin|Ku70:Ku80 complex
YNL016W YNL016W PUB1 hom Verified 1.88171109458683 0.0299376262728905 no 268 0.0293057734032796 174 NA FT PROTEIN COMPLEX ORG/BIOGENESIS NUCLEUS Poly (A)+ RNA-binding protein; abundant mRNP-component protein that binds mRNA and is required for stability of many mRNAs; component of glucose deprivation induced stress granules, involved in P-body-dependent granule assembly; protein abundance increases in response to DNA replication stress nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|stress granule assembly|regulation of mRNA stability mRNA binding|poly(U) RNA binding nucleus|cytoplasmic stress granule|cytoplasm
YGR111W_p YGR111W YGR111W hom Uncharacterized 1.88068371149258 0.03000747835593 no 269 0.0459914104630732 223 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus regulation of cell size molecular_function nucleus|cytoplasm
YNL170W_d YNL170W YNL170W hom Dubious 1.87238955974238 0.0305763641830194 no 270 0.0416421011914066 266 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPL137C YPL137C GIP3 hom Verified 1.86193185618366 0.0313063480325992 no 271 0.0312511015292852 170 NA FT CHROMOSOME SEGREGATION ENDOPLASMIC RETICULUM|MITOCHONDRION Cytoplasmic protein that regulates protein phosphatase 1 Glc7p; overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments; GIP3 has a paralog, HER1, that arose from the whole genome duplication chromosome segregation|regulation of phosphoprotein phosphatase activity protein phosphatase type 1 regulator activity|protein phosphatase 1 binding mitochondrion|ribosome|endoplasmic reticulum|cytoplasm
YBL048W_d YBL048W RRT1 hom Dubious 1.85956208708862 0.0314737537309624 no 272 0.044071031112166 251 NA Identified in a screen for mutants with increased levels of rDNA transcription; dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data Unknown Unknown Unknown
YIL138C YIL138C TPM2 hom Verified 1.85681240899595 0.0316689238223175 no 273 0.0409698241222194 222 NA FT VESICLE-MEDIATED TRANSPORT|CELL DIVISION|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|RNA LOCALIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Minor isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p; TPM2 has a paralog, TPM1, that arose from the whole genome duplication vacuole inheritance|exocytosis|intracellular mRNA localization|budding cell apical bud growth|budding cell isotropic bud growth|mitochondrion inheritance|actin polymerization or depolymerization|vesicle-mediated transport|actin filament organization|establishment of cell polarity|actin filament bundle assembly actin lateral binding cellular bud neck contractile ring|actin filament bundle
YKL003C YKL003C MRP17 hom Verified 1.85668283581818 0.0316781454485474 no 274 0.0369746445840389 157 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YHR163W YHR163W SOL3 hom Verified 1.85372766579035 0.0318890657958379 no 275 0.0288689723937774 210 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS NUCLEUS 6-phosphogluconolactonase; catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p; SOL3 has a paralog, SOL4, that arose from the whole genome duplication pentose-phosphate shunt, oxidative branch 6-phosphogluconolactonase activity nucleus|cytoplasm
YMR075C-A_d YMR075C-A YMR075C-A hom Dubious 1.84441685978415 0.0325612060491178 no 276 0.032886804405677 166 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RCO1/YMR075W Unknown Unknown Unknown
YMR115W YMR115W MGR3 hom Verified 1.84257869572912 0.0326952734053973 no 277 0.0285320346763872 155 NA FT PROTEOLYSIS MITOCHONDRION Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA misfolded or incompletely synthesized protein catabolic process misfolded protein binding mitochondrion|mitochondrial inner membrane|i-AAA complex
YMR283C YMR283C RIT1 hom Verified 1.83892913449667 0.0329628049634301 no 278 0.0229004647026665 162 NA FT RNA PROCESSING 2'-O-ribosyl phosphate transferase, modifies the initiator methionine tRNA at position 64 to distinguish it from elongator methionine tRNA charged-tRNA amino acid modification transferase activity, transferring pentosyl groups cytoplasm
YIL096C_p YIL096C YIL096C hom Uncharacterized 1.83755878848425 0.0330637231114581 no 279 0.0332250831292358 185 NA FT NUCLEUS Putative S-adenosylmethionine-dependent methyltransferase; associates with precursors of the 60S ribosomal subunit; predicted to be involved in ribosome biogenesis biological_process S-adenosylmethionine-dependent methyltransferase activity nucleolus|nucleus
YMR182C YMR182C RGM1 hom Verified 1.83679274665399 0.0331202485570572 no 280 0.0306009020906565 159 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS|CHROMOSOME Putative zinc finger DNA binding transcription factor; contains two N-terminal C2H2 zinc fingers and C-terminal proline rich domain; overproduction impairs cell growth and induces expression of genes involved in monosaccharide catabolism and aldehyde metabolism; regulates expression of of Y-prime telomeric elements and subtelomeric COS genes; RGM1 has a paralog, USV1, that arose from the whole genome duplication positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity nuclear chromatin
YGR151C_d YGR151C YGR151C hom Dubious 1.8366348107448 0.0331319123803985 no 281 0.0329990740976767 190 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF RSR1/BUD1/YGR152C; relative distribution to the nucleus increases upon DNA replication stress Unknown Unknown Unknown
YDR448W YDR448W ADA2 hom Verified 1.83539117051196 0.0332238755161394 no 282 0.0711335208408524 316 NA FF|FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS HISTONE ACETYLTRANSFERASE Transcription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes chromatin silencing at rDNA|chromatin modification|regulation of transcription from RNA polymerase II promoter|positive regulation of histone acetylation|chromatin silencing at telomere chromatin binding|transcription coactivator activity|histone acetyltransferase activity|phosphatidylserine binding SLIK (SAGA-like) complex|Ada2/Gcn5/Ada3 transcription activator complex|SAGA complex
YBR275C YBR275C RIF1 hom Verified 1.832020320486 0.0334741966000673 no 283 0.0289039166092354 160 NA FT CELL CYCLE|GENE SILENCING NUCLEUS|CHROMOSOME Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation telomere capping|telomere maintenance|chromatin silencing at silent mating-type cassette telomeric DNA binding nuclear telomere cap complex
YOR008C YOR008C SLG1 hom Verified 1.83098817835644 0.033551153792319 no 284 0.0896005476512936 386 NA FF|FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|PEROXISOME ORGANIZATION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE|CYTOSKELETON Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway; involved in maintenance of cell wall integrity; required for mitophagy; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response positive regulation of endocytosis|Rho protein signal transduction|actin cytoskeleton organization|fungal-type cell wall organization|response to heat|peroxisome degradation|establishment of cell polarity|response to osmotic stress transmembrane signaling receptor activity plasma membrane|mating projection tip|cellular bud neck
YPL181W YPL181W CTI6 hom Verified 1.83002028650763 0.0336234527014296 no 285 0.0441930378363818 247 NA FT CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain negative regulation of chromatin silencing at silent mating-type cassette|positive regulation of transcription, DNA-dependent|regulation of DNA-dependent DNA replication initiation|negative regulation of chromatin silencing at telomere|negative regulation of chromatin silencing at rDNA methylated histone residue binding|transcription factor binding Rpd3L-Expanded complex|nucleus|Rpd3L complex
YHR185C YHR185C PFS1 hom Verified 1.82893939312383 0.0337043440213438 no 286 0.038855411944188 181 NA FT CELL WALL ORG/BIOGENESIS NUCLEUS|CYTOSKELETON Sporulation protein required for prospore membrane formation at selected spindle poles, ensures functionality of all four spindle pole bodies during meiosis II; not required for meiotic recombination or meiotic chromosome segregation ascospore wall assembly molecular_function cellular_component
YJR105W YJR105W ADO1 hom Verified 1.82141324090449 0.0342720319642768 no 287 0.0873846580536538 409 NA FF|FT NUCLEOTIDE METABOLISM NUCLEUS Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle purine nucleobase metabolic process adenosine kinase activity nucleus|cytoplasm
YOR223W YOR223W YOR223W hom Verified 1.81969408226067 0.0344028025094707 no 288 0.035340140728981 201 NA FT ENDOPLASMIC RETICULUM Subunit of the DSC ubiquitin ligase complex; protein of unknown function that localizes to the ER and vacuole lumen; overexpression affects endocytic protein trafficking; ortholog of fission yeast dsc3 biological_process molecular_function fungal-type vacuole lumen|endoplasmic reticulum
YNL205C_d YNL205C YNL205C hom Dubious 1.81832838799639 0.0345069782104652 no 289 0.0366335522371035 215 NA Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDL065C YDL065C PEX19 hom Verified 1.81790352959373 0.0345394393805207 no 290 0.039106670280884 211 NA FT PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Chaperone and import receptor for newly-synthesized class I PMPs; binds peroxisomal membrane proteins (PMPs) in the cytoplasm and delivers them to the peroxisome for subsequent insertion into the peroxisomal membrane; interacts with Myo2p and contributes to peroxisome partitioning protein stabilization|protein import into peroxisome membrane|peroxisome inheritance|ER-dependent peroxisome organization|protein exit from endoplasmic reticulum peroxisome membrane targeting sequence binding|protein binding cytosol|peroxisomal membrane|endoplasmic reticulum
YHR117W YHR117W TOM71 hom Verified 1.81531383778285 0.0347378468237399 no 291 0.0260778471059595 175 NA FT MITOCHONDRION Mitochondrial outer membrane protein; probable minor component of the TOM (translocase of outer membrane) complex responsible for recognition and import of mitochondrially directed proteins; TOM71 has a paralog, TOM70, that arose from the whole genome duplication biological_process protein transporter activity mitochondrial outer membrane|mitochondrion|integral to membrane|integral to mitochondrial outer membrane
YDR319C_p YDR319C YFT2 hom Uncharacterized 1.81169278341695 0.0350168396619999 no 292 0.0343916306475254 198 NA Protein required for normal ER membrane biosynthesis; member of the highly conserved FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; interacts with Sst2p and Hsp82p in high-throughput two-hybrid screens biological_process molecular_function integral to membrane
YOR276W YOR276W CAF20 hom Verified 1.81132683570826 0.0350451370084495 no 293 0.0319674027341176 152 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION Phosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E negative regulation of translation|positive regulation of cytoplasmic mRNA processing body assembly translation regulator activity mRNA cap binding complex
YKR003W YKR003W OSH6 hom Verified 1.80361954061665 0.0356454853095226 no 294 0.0273626597346203 203 NA FT VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Member of an oxysterol-binding protein family; overlapping, redundant functions in sterol metabolism and which collectively perform a function essential for viability; GFP-fusion protein localizes to the cell periphery; overexpression extends lifespan by promoting vacuolar fusion sterol homeostasis|maintenance of cell polarity|endocytosis|sterol transport|exocytosis|sterol metabolic process phosphatidic acid binding|lipid binding|phosphatidylinositol-3,4-bisphosphate binding|oxysterol binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-5-phosphate binding|phosphatidylinositol-4-phosphate binding cortical endoplasmic reticulum|extrinsic to membrane|cytoplasm
YNL065W YNL065W AQR1 hom Verified 1.80321522887306 0.035677209851407 no 295 0.0257210965541754 145 NA FT PLASMA MEMBRANE Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids; AQR1 has a paralog, QDR1, that arose from the whole genome duplication; relocalizes from plasma membrane to cytoplasm upon DNA replication stress monocarboxylic acid transport|drug transmembrane transport|amino acid export monocarboxylic acid transmembrane transporter activity|drug transmembrane transporter activity integral to membrane|plasma membrane
YGR284C YGR284C ERV29 hom Verified 1.80205146400145 0.0357686544867055 no 296 0.0393669083700163 201 NA FT VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein localized to COPII-coated vesicles; involved in vesicle formation and incorporation of specific secretory cargo; protein abundance increases in response to DNA replication stress ER to Golgi vesicle-mediated transport molecular_function integral to membrane|ER to Golgi transport vesicle
YKL114C YKL114C APN1 hom Verified 1.79641679648828 0.0362141272553054 no 297 0.0639973588969341 372 NA FF|FT RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine base-excision repair 3'-tyrosyl-DNA phosphodiesterase activity|DNA-(apurinic or apyrimidinic site) lyase activity|double-stranded DNA specific 3'-5' exodeoxyribonuclease activity|phosphoric diester hydrolase activity mitochondrion|nucleus
YMR216C YMR216C SKY1 hom Verified 1.79388729311358 0.036415580011883 no 298 0.0889620514726321 416 NA FF|FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1 cellular cation homeostasis|cellular ion homeostasis|response to drug|protein phosphorylation|positive regulation of protein import into nucleus|regulation of cell size|mRNA splice site selection protein serine/threonine kinase activity|protein kinase activity cytoplasm
YLR213C YLR213C CRR1 hom Verified 1.78706980822385 0.0369631032564665 no 299 0.0252946254633209 132 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation ascospore wall assembly hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds ascospore wall
YLR390W YLR390W ECM19 hom Verified 1.78500528203412 0.037130230060588 no 300 0.055747513461731 260 NA FT CELL WALL ORG/BIOGENESIS MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies fungal-type cell wall organization molecular_function mitochondrion
YPL166W YPL166W ATG29 hom Verified 1.7817893110031 0.0373917980036676 no 301 0.0334294204556708 181 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|RESPONSE TO NUTRIENT LEVELS Autophagy-specific protein; required for recruiting other ATG proteins to the pre-autophagosomal structure (PAS); interacts with Atg17p and localizas to the PAS in a manner interdependent with Atg17p and Cis1p; not conserved; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress mitochondrion degradation|piecemeal microautophagy of nucleus|macroautophagy molecular_function pre-autophagosomal structure|cytoplasm
YOL035C_d YOL035C YOL035C hom Dubious 1.78009194613878 0.0375304572161302 no 302 0.0337095893576382 163 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGL153W YGL153W PEX14 hom Verified 1.77883432717095 0.0376334637669436 no 303 0.0362673771757491 204 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PEROXISOME ORGANIZATION Peroxisomal membrane peroxin that is a central component of the peroxisomal protein import machinery; interacts with both PTS1 (Pex5p) and PTS2 (Pex7p), peroxisomal matrix protein signal recognition factors and membrane receptor Pex13p protein import into peroxisome matrix, docking protein binding, bridging peroxisomal membrane
YCR020C YCR020C PET18 hom Verified 1.77339636673134 0.0380815253159114 no 304 0.0322900081387952 171 NA Protein of unknown function, has weak similarity to proteins involved in thiamin metabolism; expression is induced in the absence of thiamin thiamine metabolic process molecular_function cytosol
YJL046W YJL046W AIM22 hom Verified 1.77249893838321 0.0381558856853873 no 305 0.0371450642418576 193 NA FT MITOCHONDRION Putative lipoate-protein ligase, required along with Lip2 and Lip5 for lipoylation of Lat1p and Kgd2p; similar to E. coli LplA; null mutant displays reduced frequency of mitochondrial genome loss protein lipoylation lipoate-protein ligase activity mitochondrion
YLR252W_d YLR252W YLR252W hom Dubious 1.76946093104768 0.038408492559133 no 306 0.046051936660241 211 NA Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SYM1, a mitochondrial protein involved in ethanol metabolism Unknown Unknown Unknown
YOR026W YOR026W BUB3 hom Verified 1.7683214145117 0.0385035929378267 no 307 0.0372967770946449 230 NA FT CELL CYCLE NUCLEUS|CHROMOSOME KINETOCHORE Kinetochore checkpoint WD40 repeat protein that localizes to kinetochores during prophase and metaphase, delays anaphase in the presence of unattached kinetochores; forms complexes with Mad1p-Bub1p and with Cdc20p, binds Mad2p and Mad3p mitotic cell cycle G2/M transition decatenation checkpoint|mitotic cell cycle spindle assembly checkpoint ubiquitin binding mitotic checkpoint complex|condensed nuclear chromosome kinetochore
YDR079W YDR079W PET100 hom Verified 1.76774217218252 0.0385520081568019 no 308 0.0442980987070519 216 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme mitochondrial respiratory chain complex IV assembly|aerobic respiration unfolded protein binding mitochondrion|mitochondrial inner membrane|integral to mitochondrial inner membrane
YBL067C YBL067C UBP13 hom Verified 1.76509108858162 0.0387742290658814 no 309 0.0458160102941039 234 NA FT PROTEOLYSIS Putative ubiquitin-specific protease that cleaves Ub-protein fusions; UBP13 has a paralog, UBP9, that arose from the whole genome duplication biological_process ubiquitin-specific protease activity cellular_component
YOL027C YOL027C MDM38 hom Verified 1.76170365073438 0.039059690360985 no 310 0.047415668043541 212 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|TRANSLATION|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS MITOCHONDRION Mitochondrial protein, forms a complex with Mba1p to facilitate recruitment of mRNA-specific translational activators to ribosomes; roles in protein export and K+/H+ exchange; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome potassium ion transport|mitochondrial respiratory chain complex III biogenesis|cellular potassium ion homeostasis|proton transport|positive regulation of mitochondrial translation|mitochondrial respiratory chain complex IV biogenesis|protein insertion into mitochondrial membrane ribosome binding mitochondrion|mitochondrial inner membrane
YLL043W YLL043W FPS1 hom Verified 1.76023934877971 0.039183616442305 no 311 0.0396896896777685 257 NA FT ION HOMEOSTASIS|CARBOHYDRATE METABOLISM|ION HOMEOSTASIS PLASMA MEMBRANE Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress conjugation with cellular fusion|transport|arsenite transport|glycerol transport|acetate transport|response to arsenic-containing substance glycerol transmembrane transporter activity|transporter activity integral to membrane|plasma membrane|fungal-type vacuole|cytoplasm
YNL063W YNL063W MTQ1 hom Verified 1.75761206390374 0.0394067696295948 no 312 0.0420119718403867 196 NA FT TRANSLATION MITOCHONDRION S-adenosylmethionine-dependent methyltransferase; methylates translational release factor Mrf1p; similar to E.coli PrmC; is not an essential gene translational readthrough S-adenosylmethionine-dependent methyltransferase activity mitochondrion
YLR289W YLR289W GUF1 hom Verified 1.75708458657671 0.0394516962636683 no 313 0.0488551967536621 243 NA FT TRANSLATION|NUCLEOTIDE METABOLISM MITOCHONDRION RIBOSOME Mitochondrial matrix GTPase that associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in translational fidelity; similar to bacterial LepA elongation factor positive regulation of translation ribosome binding|GTPase activity mitochondrion|mitochondrial ribosome|mitochondrial matrix
YPR069C YPR069C SPE3 hom Verified 1.75370714654586 0.0397403501791164 no 314 0.0565054281978319 268 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM NUCLEUS Spermidine synthase, involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells spermidine biosynthetic process|pantothenate biosynthetic process spermidine synthase activity nucleus|cytoplasm
YOR096W YOR096W RPS7A hom Verified 1.75219655030014 0.0398700083184142 no 315 0.0620886130740846 259 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION NUCLEUS RIBOSOME Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7A has a paralog, RPS7B, that arose from the whole genome duplication cytoplasmic translation|ribosome biogenesis structural constituent of ribosome small-subunit processome|cytosolic small ribosomal subunit|90S preribosome
YGL060W YGL060W YBP2 hom Verified 1.75208353465944 0.0398797225338945 no 316 0.0421784979915739 283 NA FT CELL CYCLE NUCLEUS|CHROMOSOME KINETOCHORE Central kinetochore associated protein; mediates mitotic progression; interacts with several central kinetochore proteins and centromeric histone Cse4p; role in resistance to oxidative stress; similar to Slk19p; YBP2 has a paralog, YBP1, that arose from the whole genome duplication G2/M transition of mitotic cell cycle molecular_function condensed nuclear chromosome kinetochore|centromere-specific nucleosome|cytoplasm
YDR032C YDR032C PST2 hom Verified 1.74999773750217 0.0400593520664502 no 317 0.033421016727709 190 NA FT OXIDATION-REDUCTION PROCESS MITOCHONDRION Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication biological_process molecular_function mitochondrion|membrane raft|plasma membrane|cytoplasm
YMR053C YMR053C STB2 hom Verified 1.74927575011239 0.0401216828123059 no 318 0.0346657665975349 256 NA FT NUCLEUS|CHROMOSOME Protein that interacts with Sin3p in a two-hybrid assay and is part of a large protein complex with Sin3p and Stb1p biological_process molecular_function Sin3-type complex
YLR125W_p YLR125W YLR125W hom Uncharacterized 1.74807482770255 0.0402255355770867 no 319 0.0397242113811841 220 NA Putative protein of unknown function; mutant has decreased Ty3 transposition; YLR125W is not an essential gene biological_process molecular_function cellular_component
YIL027C YIL027C EMC5 hom Verified 1.74156483882737 0.0407923092045352 no 320 0.0542917893711872 270 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response, and also shows K1 killer toxin resistance; homologous to worm B0334.15/EMC-5, fly CG15168, human MMGT protein folding in endoplasmic reticulum molecular_function ER membrane protein complex|endoplasmic reticulum
YHR204W YHR204W MNL1 hom Verified 1.73923730664934 0.0409965149030744 no 321 0.0368047869133687 242 NA FT PROTEOLYSIS ENDOPLASMIC RETICULUM Alpha-1,2-specific exomannosidase of the endoplasmic reticulum; in complex with Pdi1p, generates a Man7GlcNac2 oligosaccharide signal on glycoproteins destined for ubiquitin-proteasome degradation ER-associated protein catabolic process carbohydrate binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity endoplasmic reticulum lumen
YLR031W_p YLR031W YLR031W hom Uncharacterized 1.73676948602972 0.0412139335572109 no 322 0.0487510557970586 245 NA Putative protein of unknown function biological_process molecular_function cellular_component
YCL011C YCL011C GBP2 hom Verified 1.72947710484779 0.0418618703414493 no 323 0.055998355475822 247 NA FT RNA LOCALIZATION NUCLEUS|CHROMOSOME Poly(A+) RNA-binding protein; involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Npl3p; also binds single-stranded telomeric repeat sequence in vitro; GBP2 has a paralog, HRB1, that arose from the whole genome duplication poly(A)+ mRNA export from nucleus|telomere maintenance RNA binding|telomeric DNA binding nucleus|cytoplasmic stress granule
YGR038W YGR038W ORM1 hom Verified 1.72874402086567 0.0419274594799451 no 324 0.0678770004395039 268 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Evolutionarily conserved protein, similar to Orm2p, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control cellular sphingolipid homeostasis|negative regulation of sphingolipid biosynthetic process|response to unfolded protein molecular_function integral to membrane|endoplasmic reticulum|SPOTS complex
YAL067C YAL067C SEO1 hom Verified 1.72799460702398 0.0419945956286101 no 325 0.033804359120857 171 NA Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide transport transporter activity integral to membrane|membrane
YIR020C_p YIR020C YIR020C hom Uncharacterized 1.72660194494794 0.0421195882013104 no 326 0.0252845114639941 153 NA Protein of unknown function; mRNA identified as translated by ribosome profiling data biological_process molecular_function cellular_component
YDR439W YDR439W LRS4 hom Verified 1.72574410574211 0.0421967297128166 no 327 0.051086624449617 301 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CHROMOSOME SEGREGATION|GENE SILENCING NUCLEUS|CHROMOSOME KINETOCHORE Nucleolar protein that forms a complex with Csm1p, and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation rDNA condensation|chromatin silencing at rDNA|homologous chromosome segregation|protein localization to nucleolar rDNA repeats molecular_function nucleolus|nucleus|monopolin complex
YOL076W YOL076W MDM20 hom Verified 1.71808192928928 0.042890836213676 no 328 0.0657364092923197 382 NA FF|FT MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly mitochondrion inheritance|N-terminal peptidyl-methionine acetylation|cytoskeleton organization peptide alpha-N-acetyltransferase activity NatB complex
YGL179C YGL179C TOS3 hom Verified 1.71601999129214 0.0430791917649064 no 329 0.0283712340159911 180 NA FT CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome protein phosphorylation|glucose metabolic process protein serine/threonine kinase activity|protein kinase activity nucleus|cytoplasm
YJR062C YJR062C NTA1 hom Verified 1.71173683919258 0.0434725881928545 no 330 0.0327943527011002 191 NA FT PROTEOLYSIS MITOCHONDRION Amidase, removes the amide group from N-terminal asparagine and glutamine residues to generate proteins with N-terminal aspartate and glutamate residues that are targets of ubiquitin-mediated degradation cellular protein modification process|protein catabolic process protein-N-terminal asparagine amidohydrolase activity mitochondrion
YGR146C YGR146C ECL1 hom Verified 1.70635558607828 0.0439709472686209 no 331 0.0473561872155936 219 NA Protein of unknown function; mitochondrial-dependent role in the extension of chronological lifespan; overexpression increases oxygen consumption and respiratory activity while deletion results in reduced oxygen consumption under conditions of caloric restriction; induced by iron homeostasis transcription factor Aft2p; multicopy suppressor of temperature sensitive hsf1 mutant; induced by treatment with 8-methoxypsoralen and UVA irradiation biological_process molecular_function cellular_component
YDR284C YDR284C DPP1 hom Verified 1.70543452554415 0.0440567068935838 no 332 0.040640320240839 228 NA FT LIPID METABOLISM|SIGNALING Diacylglycerol pyrophosphate (DGPP) phosphatase, zinc-regulated vacuolar membrane-associated lipid phosphatase, dephosphorylates DGPP to phosphatidate (PA) and Pi, then PA to diacylglycerol; involved in lipid signaling and cell metabolism phospholipid metabolic process|signal transduction diacylglycerol diphosphate phosphatase activity|phosphatidate phosphatase activity fungal-type vacuole membrane|integral to membrane
YOR162C YOR162C YRR1 hom Verified 1.70463437770975 0.0441313178063812 no 333 0.0803910805489173 347 NA FF|FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO OXIDATIVE STRESS NUCLEUS Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication regulation of transcription from RNA polymerase II promoter in response to oxidative stress|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity nucleus
YDR462W YDR462W MRPL28 hom Verified 1.70200678278056 0.0443770483895501 no 334 0.049109024004962 276 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YBR164C YBR164C ARL1 hom Verified 1.69809896346769 0.0447445425985467 no 335 0.106120154563646 465 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|VACUOLAR TRANSPORT GOLGI APPARATUS Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor Golgi to plasma membrane protein transport|vesicle-mediated transport|protein targeting to vacuole GTPase activity trans-Golgi network|cytosol|Golgi apparatus
YDR443C YDR443C SSN2 hom Verified 1.6972866215742 0.0448212426525374 no 336 0.0656090649752531 283 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS NUCLEUS Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter by galactose RNA polymerase II transcription coactivator activity|RNA polymerase II transcription factor recruiting transcription factor activity mediator complex
YDR161W_p YDR161W YDR161W hom Uncharacterized 1.68970559360801 0.0455421463004827 no 337 0.0475231853663828 222 NA FT PROTEOLYSIS NUCLEUS Putative protein of unknown function; non-essential gene; proposed function in rRNA and ribosome biosynthesis based on transcriptional co-regulation; genetic interactions suggest a role in ER-associated protein degradation (ERAD) ER-associated protein catabolic process molecular_function nucleus|cytoplasm
YLR043C YLR043C TRX1 hom Verified 1.68668840922195 0.0458316409930411 no 338 0.0431331578354779 244 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance; protein abundance increases in response to DNA replication stress vacuole inheritance|regulation of DNA replication|cell redox homeostasis|protein deglutathionylation|retrograde vesicle-mediated transport, Golgi to ER|cellular response to oxidative stress|ER to Golgi vesicle-mediated transport|vacuole fusion, non-autophagic disulfide oxidoreductase activity cytosol|fungal-type vacuole
YDR432W YDR432W NPL3 hom Verified 1.68373844544364 0.0461161139393086 no 339 0.0661507125124061 343 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION NUCLEUS RNA-binding protein; promotes elongation, regulates termination, and carries poly(A) mRNA from nucleus to cytoplasm; has a role in repressing translation initiation by binding eIF4G; required for pre-mRNA splicing; dissociation from mRNAs promoted by Mtr10p; phosphorylated by Sky1p in the cytoplasm; protein abundance increases in response to DNA replication stress translational termination|mRNA export from nucleus|negative regulation of translation|mRNA splicing, via spliceosome|Unknown|positive regulation of transcription elongation from RNA polymerase II promoter mRNA binding|RNA polymerase II core binding|eukaryotic initiation factor 4G binding|poly(A) RNA binding nucleus|cytoplasm
YPR127W YPR127W YPR127W hom Verified 1.68275799657328 0.0462109746631682 no 340 0.0411273260701243 252 NA FT OXIDATION-REDUCTION PROCESS NUCLEUS Putative pyridoxine 4-dehydrogenase; differentially expressed during alcoholic fermentation; expression activated by transcription factor YRM1/YOR172W; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus biological_process molecular_function nucleus|cytoplasm
YOL163W_p YOL163W YOL163W hom Uncharacterized 1.68026305095707 0.0464530733236097 no 341 0.0375566062968677 157 NA Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family transmembrane transport transmembrane transporter activity integral to membrane|membrane
YMR056C YMR056C AAC1 hom Verified 1.67557765675673 0.0469104741564956 no 342 0.0402541436646163 240 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator; relocalizes from mitochondrion to cytoplasm upon DNA replication stress heme biosynthetic process|mitochondrial transport|heme transport|aerobic respiration ATP:ADP antiporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YJR104C YJR104C SOD1 hom Verified 1.67232238332659 0.0472303840847337 no 343 0.143570239395782 582 NA FF|FT ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS NUCLEUS|MITOCHONDRION Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid cellular copper ion homeostasis|fungal-type cell wall organization|superoxide metabolic process|cellular zinc ion homeostasis|positive regulation of sequence-specific DNA binding transcription factor activity|age-dependent response to reactive oxygen species involved in chronological cell aging superoxide dismutase activity cytosol|mitochondrion|nucleus|mitochondrial intermembrane space
YIL072W YIL072W HOP1 hom Verified 1.67183314973029 0.0472786140027145 no 344 0.0725615273738822 302 NA FT CELL CYCLE NUCLEUS|CHROMOSOME Meiosis-specific protein required for chromosome synapsis; displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex; required for chiasma formation; in vitro, displays the ability to promote intra- and intermolecular synapsis between double-stranded DNA molecules and to fold DNA into rigid protein?DNA filaments synaptonemal complex assembly|meiotic recombination checkpoint|synapsis four-way junction DNA binding condensed nuclear chromosome|lateral element
YJL183W YJL183W MNN11 hom Verified 1.67055408451595 0.0474048940862091 no 345 0.0725733961290827 318 NA FT CARBOHYDRATE METABOLISM GOLGI APPARATUS Subunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p protein glycosylation alpha-1,6-mannosyltransferase activity alpha-1,6-mannosyltransferase complex
YGL202W YGL202W ARO8 hom Verified 1.66958813612525 0.0475004396447573 no 346 0.0328973234710533 169 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis aromatic amino acid family metabolic process aromatic-amino-acid:2-oxoglutarate aminotransferase activity|2-aminoadipate transaminase activity cytoplasm
YMR158W YMR158W MRPS8 hom Verified 1.6642161165202 0.0480346242399803 no 347 0.0461415294622622 232 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YBL091C-A YBL091C-A SCS22 hom Verified 1.66222780240775 0.0482335537405603 no 348 0.0469274838342647 235 NA FT LIPID METABOLISM Protein involved in regulation of phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; similar to D. melanogaster inturned protein; SCS22 has a paralog, SCS2, that arose from the whole genome duplication phospholipid biosynthetic process|chromatin silencing at telomere molecular_function cellular_component
YJL214W YJL214W HXT8 hom Verified 1.65781614235084 0.0486772910508753 no 349 0.0480024770507633 226 NA FT PLASMA MEMBRANE Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose hexose transport mannose transmembrane transporter activity|glucose transmembrane transporter activity|fructose transmembrane transporter activity integral to membrane|plasma membrane
YGL054C YGL054C ERV14 hom Verified 1.65688157964582 0.0487717096078123 no 350 0.159592007426508 615 NA FF|FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|SIGNALING|CELL DIVISION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS COPII-coated vesicle protein; involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon; ERV14 has a paralog, ERV15, that arose from the whole genome duplication ascospore formation|ER to Golgi vesicle-mediated transport|axial cellular bud site selection molecular_function integral to membrane|ER to Golgi transport vesicle|endoplasmic reticulum membrane
YIL130W YIL130W ASG1 hom Verified 1.65362333559709 0.0491020341330558 no 351 0.0432459478747527 264 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Zinc cluster protein proposed to function as a transcriptional regulator involved in the stress response; null mutants have a respiratory deficiency, calcofluor white sensitivity and slightly increased cycloheximide resistance biological_process sequence-specific DNA binding nucleus
YPR109W_p YPR109W YPR109W hom Uncharacterized 1.64931063635911 0.0495420058578151 no 352 0.061834888932582 251 NA FT CELL CYCLE Predicted membrane protein; dipoid deletion strain has high budding index biological_process molecular_function cellular_component
YGL066W YGL066W SGF73 hom Verified 1.64908539258181 0.0495650708896057 no 353 0.070455399405585 270 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|RNA LOCALIZATION NUCLEUS HISTONE ACETYLTRANSFERASE SAGA complex subunit; has a role in anchoring the deubiquitination module into SAGA and SLIK complexes; involved in preinitiation complex assembly at promoters; human ortholog ataxin-7 is associated with spinocerebellar ataxia diseases; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay histone deubiquitination|mRNA export from nucleus|histone acetylation|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|protein complex assembly|chromatin modification histone acetyltransferase activity|enzyme activator activity|structural molecule activity DUBm complex|SLIK (SAGA-like) complex|SAGA complex
YJL075C_d YJL075C APQ13 hom Dubious 1.64878964522035 0.0495953685223961 no 354 0.0485509903494045 239 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene NET1; null mutant is sensitive to sorbate Unknown Unknown Unknown
YMR169C YMR169C ALD3 hom Verified 1.64859439641233 0.0496153787488106 no 355 0.0499857232950366 242 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS Cytoplasmic aldehyde dehydrogenase, involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose beta-alanine biosynthetic process|polyamine catabolic process aldehyde dehydrogenase (NAD) activity cytoplasm
YGL222C YGL222C EDC1 hom Verified 1.64607869523604 0.0498737790435395 no 356 0.0432130777174986 171 NA FT RNA PROCESSING|TRANSLATION NUCLEUS RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress deadenylation-dependent decapping of nuclear-transcribed mRNA|positive regulation of translation in response to stress mRNA binding nucleus|cytoplasm
YGR162W YGR162W TIF4631 hom Verified 1.64533673220145 0.0499501944239205 no 357 0.0624542025541075 287 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION MITOCHONDRION RIBOSOME Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication translational initiation|ribosomal large subunit biogenesis|stress granule assembly translation initiation factor activity mitochondrion|ribosome|eukaryotic translation initiation factor 4F complex|cytoplasmic stress granule
YIL073C YIL073C SPO22 hom Verified 1.64397496444911 0.0500906869260055 no 358 0.0380285908379637 212 NA FT CELL CYCLE NUCLEUS|CHROMOSOME Meiosis-specific protein essential for chromosome synapsis, involved in completion of nuclear divisions during meiosis; induced early in meiosis regulation of synaptonemal complex assembly molecular_function condensed nuclear chromosome
YGR043C YGR043C NQM1 hom Verified 1.64389858530436 0.050098576223487 no 359 0.0439319700791854 204 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS NUCLEUS Transaldolase of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift biological_process sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity nucleus
YGL147C YGL147C RPL9A hom Verified 1.64251395693332 0.0502417680587162 no 360 0.0514301906166881 268 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L9A; nearly identical to paralog Rpl9Bp; homologous to mammalian ribosomal protein L9 and bacterial L6 cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YBR131W YBR131W CCZ1 hom Verified 1.63470138926754 0.0510558305666835 no 361 0.0481046675101962 271 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Protein involved in vacuolar assembly, essential for autophagy and the cytoplasm-to-vacuole pathway autophagy|autophagic vacuole fusion|vacuolar transport|vesicle docking|protein targeting to vacuole guanyl-nucleotide exchange factor activity Mon1-Ccz1 complex|membrane
YLL045C YLL045C RPL8B hom Verified 1.63361540013663 0.0511698160625969 no 362 0.0481723290423363 218 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal 60S subunit protein L8B; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8B has a paralog, RPL8A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YER150W YER150W SPI1 hom Verified 1.63294924017969 0.0512398364008453 no 363 0.0535357611365414 268 NA GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p response to acid molecular_function fungal-type cell wall
YAL044C YAL044C GCV3 hom Verified 1.63220389839237 0.051318269911366 no 364 0.0781366497515463 386 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5,10-methylene-THF glycine catabolic process|one-carbon metabolic process|protein lipoylation glycine dehydrogenase (decarboxylating) activity mitochondrion|glycine cleavage complex
YDR463W YDR463W STP1 hom Verified 1.63056604135518 0.0514909597550232 no 365 0.119176081860768 392 NA FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS|PLASMA MEMBRANE Transcription factor; undergoes proteolytic processing by SPS (Ssy1p-Ptr3p-Ssy5p)-sensor component Ssy5p in response to extracellular amino acids; activates transcription of amino acid permease genes and may have a role in tRNA processing; STP1 has a paralog, STP2, that arose from the whole genome duplication positive regulation of transcription, DNA-dependent|tRNA splicing, via endonucleolytic cleavage and ligation|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription plasma membrane|nucleus|cytoplasm
YOL158C YOL158C ENB1 hom Verified 1.6262293106024 0.0519504415519273 no 366 0.0478738007959124 177 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Endosomal ferric enterobactin transporter, expressed under conditions of iron deprivation; member of the major facilitator superfamily; expression is regulated by Rcs1p and affected by chloroquine treatment ferric-enterobactin transport ferric-enterobactin transmembrane transporter activity integral to membrane|cellular bud membrane|plasma membrane
YEL059C-A YEL059C-A SOM1 hom Verified 1.62363170696586 0.0522272171242444 no 367 0.0426711945685674 208 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs proteolysis|mitochondrial respiratory chain complex assembly endopeptidase activity mitochondrial inner membrane peptidase complex|mitochondrial inner membrane
YKR097W YKR097W PCK1 hom Verified 1.62348044017101 0.0522433706677453 no 368 0.0512028886809642 306 NA FT CARBOHYDRATE METABOLISM Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol gluconeogenesis phosphoenolpyruvate carboxykinase (ATP) activity cytosol
YGL165C_d YGL165C YGL165C hom Dubious 1.62265591592723 0.0523314900845385 no 369 0.0407283155879893 176 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CUP2/YGL166W Unknown Unknown Unknown
YGR035C_p YGR035C YGR035C hom Uncharacterized 1.62134317633112 0.0524720300425917 no 370 0.0386116877316406 200 NA Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance biological_process molecular_function cellular_component
YFL047W YFL047W RGD2 hom Verified 1.61955469308351 0.052663984376674 no 371 0.0543753654776831 265 NA FT SIGNALING SITE OF POLARIZED GROWTH GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p; relocalizes from bud neck to cytoplasm upon DNA replication stress small GTPase mediated signal transduction Rho GTPase activator activity cellular bud neck|cytoplasm
YEL045C_d YEL045C YEL045C hom Dubious 1.61858340673838 0.0527684638430728 no 372 0.0813471101389357 338 NA Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; deletion gives MMS sensitivity, growth defect under alkaline conditions, less than optimal growth upon citric acid stress Unknown Unknown Unknown
YER081W YER081W SER3 hom Verified 1.61807057467811 0.0528236945334456 no 373 0.0539205716361583 211 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS 3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER3 has a paralog, SER33, that arose from the whole genome duplication serine family amino acid biosynthetic process phosphoglycerate dehydrogenase activity cytoplasm
YDR340W_d YDR340W YDR340W hom Dubious 1.61742351468681 0.0528934466494466 no 374 0.0380936251300215 179 NA Putative protein of unknown function Unknown Unknown Unknown
YGL175C YGL175C SAE2 hom Verified 1.61659384871328 0.0529829902938177 no 375 0.0449071902127503 254 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS Endonuclease that processes hairpin DNA structures with the MRX complex; involved in meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents DNA double-strand break processing|DNA catabolic process, endonucleolytic|meiotic DNA double-strand break formation|meiotic DNA double-strand break processing|gene conversion at mating-type locus, DNA double-strand break processing double-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity nucleus|cytoplasm
YIL016W YIL016W SNL1 hom Verified 1.61639984083318 0.0530039463822622 no 376 0.046272059231698 273 NA FT ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION Ribosome-associated protein proposed to act in protein synthesis and nuclear pore complex biogenesis and maintenance as well as protein folding; has similarity to the mammalian BAG-1 protein protein folding|nuclear pore organization ribosome binding nuclear envelope|mitochondrion|cytosolic ribosome|endoplasmic reticulum membrane|membrane
YML095C YML095C RAD10 hom Verified 1.61412550739694 0.0532501028431911 no 377 0.0395707654757795 207 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS Single-stranded DNA endonuclease (with Rad1p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein mitotic recombination|meiotic mismatch repair|DNA strand renaturation|nucleotide-excision repair, DNA incision, 5'-to lesion|removal of nonhomologous ends|double-strand break repair via single-strand annealing, removal of nonhomologous ends single-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity nucleotide-excision repair factor 1 complex|nucleus
YKL134C YKL134C OCT1 hom Verified 1.61273124335591 0.0534014548086092 no 378 0.0566961632190332 270 NA FT PROTEIN LOCALIZATION|ION HOMEOSTASIS|PROTEOLYSIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS MITOCHONDRION Mitochondrial intermediate peptidase, cleaves destabilizing N-terminal residues of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may contribute to mitochondrial iron homeostasis cellular iron ion homeostasis|protein processing involved in protein targeting to mitochondrion metalloendopeptidase activity mitochondrion
YLR435W YLR435W TSR2 hom Verified 1.61246610371825 0.0534302751331747 no 379 0.0512088519758153 275 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Protein with a potential role in pre-rRNA processing maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function nucleus|cytoplasm
YPL136W_d YPL136W YPL136W hom Dubious 1.61206086415559 0.0534743479463859 no 380 0.064826351343481 278 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene GIP3/YPL137C Unknown Unknown Unknown
YBR072W YBR072W HSP26 hom Verified 1.61171600802375 0.0535118762957502 no 381 0.0464848807750926 250 NA FT NUCLEUS Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires heat-induced conformational change; also has mRNA binding activity protein folding|response to stress unfolded protein binding|mRNA binding nucleus|cytoplasm
YFL030W YFL030W AGX1 hom Verified 1.61093736889182 0.0535966870498452 no 382 0.0443279536401624 215 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases glycine biosynthetic process, by transamination of glyoxylate alanine-glyoxylate transaminase activity mitochondrion
YDL013W YDL013W SLX5 hom Verified 1.60836791861039 0.0538773117933326 no 383 0.0824566141564155 359 NA FT RESPONSE TO DNA DAMAGE NUCLEUS UBIQUITIN LIGASE COMPLEX Subunit of the Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex, stimulated by SUMO-modified substrates; contains a RING domain and two SIMs (SUMO-interacting motifs); forms SUMO-dependent nuclear foci, including DNA repair centers protein sumoylation|telomere maintenance|response to DNA damage stimulus|protein ubiquitination SUMO binding|ubiquitin-protein ligase activity ubiquitin ligase complex|nucleus
YHR158C YHR158C KEL1 hom Verified 1.6076772286881 0.0539529441496358 no 384 0.0544984609350443 245 NA FT CELL CYCLE|MEMBRANE ORGANIZATION SITE OF POLARIZED GROWTH Protein required for proper cell fusion and cell morphology; functions in a complex with Kel2p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate negative regulation of exit from mitosis|regulation of cell shape|cell morphogenesis|cytogamy|plasma membrane fusion molecular_function mating projection tip|cellular bud neck|cytoplasm|cellular bud tip
YNL135C YNL135C FPR1 hom Verified 1.6048521989914 0.0542631676424833 no 385 0.0669720313851257 322 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|CHROMATIN ORGANIZATION NUCLEUS|MITOCHONDRION Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function protein folding|chromatin organization|homoserine metabolic process peptidyl-prolyl cis-trans isomerase activity|macrolide binding mitochondrion|nucleus|cytoplasm
YMR174C YMR174C PAI3 hom Verified 1.60334686109976 0.0544290479731661 no 386 0.0465781702626151 225 NA Cytoplasmic proteinase A (Pep4p) inhibitor, dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact vacuolar protein catabolic process endopeptidase inhibitor activity cytoplasm
YGL185C_p YGL185C YGL185C hom Uncharacterized 1.60186128696144 0.0545931434285642 no 387 0.0737678652698738 304 NA FT OXIDATION-REDUCTION PROCESS Putative protein with sequence similarity to hydroxyacid dehydrogenases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm metabolic process oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor cytoplasm
YDR019C YDR019C GCV1 hom Verified 1.59562172690326 0.0552866368427571 no 388 0.0645454141372211 278 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION T subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm glycine catabolic process|glycine metabolic process|one-carbon metabolic process glycine dehydrogenase (decarboxylating) activity mitochondrion|glycine cleavage complex
YER149C YER149C PEA2 hom Verified 1.59411564951779 0.0554550671972969 no 389 0.0495785143439787 237 NA FT CELL CYCLE|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Coiled-coil polarisome protein required for polarized morphogenesis, cell fusion, and low affinity Ca2+ influx; forms polarisome complex with Bni1p, Bud6p, and Spa2p; localizes to sites of polarized growth bipolar cellular bud site selection|regulation of initiation of mating projection growth|regulation of termination of mating projection growth|actin filament organization|pseudohyphal growth|establishment of cell polarity|filamentous growth|Rho protein signal transduction cytoskeletal regulatory protein binding polarisome|actin cap|mating projection tip
YJR032W YJR032W CPR7 hom Verified 1.59256951109955 0.0556283988954676 no 390 0.0660576389054007 290 NA Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity protein refolding|response to stress unfolded protein binding|peptidyl-prolyl cis-trans isomerase activity cytosol
YMR289W YMR289W ABZ2 hom Verified 1.59243967921328 0.055642973293881 no 391 0.0634909404575619 309 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis folic acid biosynthetic process 4-amino-4-deoxychorismate lyase activity cytoplasm
YCL037C YCL037C SRO9 hom Verified 1.59211907416272 0.055678976019966 no 392 0.0855680957729947 377 NA FT TRANSLATION Cytoplasmic RNA-binding protein; associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif; SRO9 has a paralog, SLF1, that arose from the whole genome duplication cytoplasmic translation RNA binding polysome
YBR282W YBR282W MRPL27 hom Verified 1.58971500740733 0.0559495296615398 no 393 0.0546307151642935 287 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit; homolog of human Bcl-2 interacting protein BMRP mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YOL056W YOL056W GPM3 hom Verified 1.58712491146186 0.0562421784182541 no 394 0.0515322041925872 254 NA FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event biological_process phosphoglycerate mutase activity|molecular_function cytosol
YMR154C YMR154C RIM13 hom Verified 1.57845590801129 0.0572304549612828 no 395 0.061792563663754 379 NA FF|FT ION HOMEOSTASIS|PROTEOLYSIS|ION HOMEOSTASIS Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB protein processing cysteine-type endopeptidase activity cellular_component
YOR082C_d YOR082C YOR082C hom Dubious 1.57051634221709 0.0581475177476368 no 396 0.0486401414228155 215 NA Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene YOR083W Unknown Unknown Unknown
YDL161W YDL161W ENT1 hom Verified 1.56921871337887 0.0582984926252442 no 397 0.0396706053432271 179 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Epsin-like protein involved in endocytosis and actin patch assembly; functionally redundant with Ent2p; binds clathrin via a clathrin-binding domain motif at C-terminus; relocalizes from bud neck to cytoplasm upon DNA replication stress actin filament organization|endocytosis|actin cortical patch assembly clathrin binding mating projection tip|actin cortical patch
YNR023W YNR023W SNF12 hom Verified 1.5692072527976 0.0582998273968631 no 398 0.165937824695694 576 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS NUCLEUS RSC COMPLEX 73 kDa subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; homolog of Rsc6p subunit of the RSC chromatin remodeling complex; relocates to the cytosol under hypoxic conditions; deletion mutants are temperature-sensitive positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation|positive regulation of transcription from RNA polymerase II promoter molecular_function SWI/SNF complex
YDL156W YDL156W CMR1 hom Verified 1.56907163423542 0.0583156242132735 no 399 0.0673459927444078 269 NA FT NUCLEUS|CHROMOSOME DNA-binding protein with preference for UV-damaged DNA; protein sequence contains three WD domains (WD-40 repeat); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; potential regulatory target of Mbp1p, which binds to the promoter region; co-localizes with Hos2p in nuclear foci in response to DNA damage by MMS biological_process DNA binding nuclear chromatin|nucleus|cytoplasm
YAL047C YAL047C SPC72 hom Verified 1.56841694450389 0.0583919296050484 no 400 0.0625833553684381 292 NA FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION NUCLEUS|CYTOSKELETON Component of the cytoplasmic Tub4p (gamma-tubulin) complex, binds spindle pole bodies and links them to microtubules; has roles in astral microtubule formation and stabilization microtubule nucleation|nuclear migration along microtubule|mitotic cell cycle spindle orientation checkpoint|mitotic spindle elongation|mitotic sister chromatid segregation structural constituent of cytoskeleton outer plaque of spindle pole body
YBR071W YBR071W YBR071W hom Verified 1.56827941141916 0.0584079693222048 no 401 0.0473979852661289 213 NA FT SITE OF POLARIZED GROWTH Protein of unknown function found in the cytoplasm and bud neck; mRNA expression may be regulated by the cell cycle and/or cell wall stress; overexpression of YBR071W affects endocytic protein trafficking biological_process molecular_function cellular bud neck|cytoplasm
YKR051W_p YKR051W YKR051W hom Uncharacterized 1.56258165404961 0.0590755131081297 no 402 0.0647217603183703 280 NA Putative protein of unknown function biological_process molecular_function integral to membrane
YDR332W YDR332W IRC3 hom Verified 1.56226336310437 0.0591129795373729 no 403 0.0618616080548161 331 NA FT MITOCHONDRION Putative RNA helicase of the DEAH/D-box family; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion biological_process ATP-dependent RNA helicase activity mitochondrion
YOR342C YOR342C YOR342C hom Verified 1.55786239743815 0.0596329353301755 no 404 0.06852710801286 281 NA FT NUCLEUS Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; relocalizes from nucleus to cytoplasm upon DNA replication stress; YOR342C has a paralog, YAL037W, that arose from the whole genome duplication biological_process molecular_function nucleus|cytoplasm
YDL215C YDL215C GDH2 hom Verified 1.55781931151307 0.0596380434111088 no 405 0.0467408127991424 190 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION NAD(+)-dependent glutamate dehydrogenase, degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels nitrogen compound metabolic process glutamate dehydrogenase (NAD+) activity mitochondrion
YCR101C_p YCR101C YCR101C hom Uncharacterized 1.55585703736413 0.0598710457529213 no 406 0.0606407852618359 326 NA Putative protein of unknown function; localizes to the membrane fraction; YCR101C is not an essential gene biological_process molecular_function integral to membrane|membrane
YFR031C-A YFR031C-A RPL2A hom Verified 1.55579861298897 0.059877994035665 no 407 0.0567938875886502 258 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L2A; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2A has a paralog, RPL2B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YJL186W YJL186W MNN5 hom Verified 1.55152259776798 0.0603882480848558 no 408 0.0425617797697134 231 NA FT CARBOHYDRATE METABOLISM GOLGI APPARATUS Alpha-1,2-mannosyltransferase, responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment protein glycosylation alpha-1,2-mannosyltransferase activity Golgi apparatus
YMR161W YMR161W HLJ1 hom Verified 1.55051983062279 0.0605083987772514 no 409 0.069115734412048 274 NA FT PROTEOLYSIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Co-chaperone for Hsp40p, anchored in the ER membrane; with its homolog Ydj1p promotes ER-associated protein degradation (ERAD) of integral membrane substrates; similar to E. coli DnaJ ER-associated protein catabolic process ATPase activator activity endoplasmic reticulum|endoplasmic reticulum membrane
YDR112W_d YDR112W IRC2 hom Dubious 1.54846621629589 0.0607550447510745 no 410 0.0556633204861355 278 NA Dubious open reading frame, unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR111C; null mutant displays increased levels of spontaneous Rad52p foci Unknown Unknown Unknown
YMR063W YMR063W RIM9 hom Verified 1.54736590171019 0.0608875193444943 no 411 0.112822207130563 496 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Plasma membrane protein of unknown function; involved in the proteolytic activation of Rim101p in response to alkaline pH; interacts with Rim21p and Dfg16p to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; has similarity to A. nidulans PalI; ascospore formation molecular_function integral to membrane
YPR156C YPR156C TPO3 hom Verified 1.54722948698923 0.0609039589937553 no 412 0.0468612653476084 240 NA FT PLASMA MEMBRANE Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; TPO3 has a paralog, TPO2, that arose from the whole genome duplication spermine transport spermine transmembrane transporter activity fungal-type vacuole membrane|integral to membrane|plasma membrane
YOR376W-A_p YOR376W-A YOR376W-A hom Uncharacterized 1.54539142566944 0.0611258065169713 no 413 0.0453595950715975 215 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YDR034W-B_p YDR034W-B YDR034W-B hom Uncharacterized 1.53824540769338 0.0619943111639248 no 414 0.0644568245699931 267 NA Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery biological_process molecular_function cellular_component
YCR076C YCR076C FUB1 hom Verified 1.53757606976574 0.062076151139913 no 415 0.0884476709424662 343 NA Putative protein of unknown function; interacts physically with multiple subunits of the 20S proteasome and genetically with genes encoding 20S core particle and 19S regulatory particle subunits; exhibits boundary activity which blocks the propagation of heterochromatic silencing; contains a PI31 proteasome regulator domain and sequence similarity with human PSMF1, a proteasome inhibitor; not an essential gene biological_process proteasome binding cellular_component
YOL114C_p YOL114C YOL114C hom Uncharacterized 1.5373293150581 0.0621063431051209 no 416 0.0652490334813028 301 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION Putative protein of unknown function with similarity to human ICT1 and prokaryotic factors that may function in translation termination; YOL114C is not an essential gene biological_process molecular_function cellular_component
YOR231W YOR231W MKK1 hom Verified 1.52956651449895 0.0630620316320709 no 417 0.0600932134700332 276 NA FT SIGNALING|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION SITE OF POLARIZED GROWTH MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication signal transduction|peroxisome degradation|protein phosphorylation protein kinase activity|MAP kinase kinase activity cellular bud tip
YDR529C YDR529C QCR7 hom Verified 1.5285383042849 0.0631894703753003 no 418 0.0853528174628961 373 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Subunit 7 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the mitochondrial matrix; N-terminus appears to play a role in complex assembly mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration|mitochondrial respiratory chain complex III assembly ubiquinol-cytochrome-c reductase activity mitochondrion|integral to membrane|mitochondrial respiratory chain complex III
YDR399W YDR399W HPT1 hom Verified 1.5254235365037 0.0635767459501584 no 419 0.0529502591891307 241 NA FT NUCLEOTIDE METABOLISM NUCLEUS Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the transfer of the phosphoribosyl portion of 5-phosphoribosyl-alpha-1-pyrophosphate to a purine base (either guanine or hypoxanthine) to form pyrophosphate and a purine nucleotide (either guanosine monophosphate or inosine monophosphate); mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome GMP salvage|IMP salvage hypoxanthine phosphoribosyltransferase activity nucleus|cytoplasm
YDL119C_p YDL119C YDL119C hom Uncharacterized 1.52437085028612 0.0637080487731635 no 420 0.0735788946494319 382 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Putative mitochondrial transport protein; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in purified mitochondria transport transporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YHL019C YHL019C APM2 hom Verified 1.52291429173562 0.0638900748609988 no 421 0.0549229321487296 292 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport Golgi to vacuole transport|vesicle-mediated transport clathrin binding AP-1 adaptor complex
YPR124W YPR124W CTR1 hom Verified 1.51549184090539 0.0648239475046743 no 422 0.162349490651456 610 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE High-affinity copper transporter of the plasma membrane; mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels; protein increases in abundance and relocalizes from nucleus to plasma membrane upon DNA replication stress copper ion import copper uptake transmembrane transporter activity integral to membrane|plasma membrane
YMR313C YMR313C TGL3 hom Verified 1.5105518437052 0.0654513355702111 no 423 0.0600521376923997 258 NA FT LIPID METABOLISM|CELL DIVISION Bifunctional enzyme with triacylglycerol lipase and lysophosphatidylethanolamine acyltransferase activity; responsible for all the triacylglycerol lipase activity of the lipid particle; required with Tgl4p for timely bud formation triglyceride catabolic process|cell budding|cellular lipid metabolic process triglyceride lipase activity|lysophosphatidylethanolamine acyltransferase activity lipid particle
YMR256C YMR256C COX7 hom Verified 1.51020122871944 0.0654960426354221 no 424 0.0907067454088392 362 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain mitochondrial electron transport, cytochrome c to oxygen cytochrome-c oxidase activity mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YGL031C YGL031C RPL24A hom Verified 1.50923496458764 0.0656193739533959 no 425 0.0727877244760513 333 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L24A; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24A has a paralog, RPL24B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YKL091C YKL091C YKL091C hom Verified 1.50890052933597 0.0656621022777272 no 426 0.0685819638437196 287 NA FT NUCLEUS Putative homolog of Sec14p, which is a phosphatidylinositol/phosphatidylcholine transfer protein involved in lipid metabolism; localizes to the nucleus; contains a CRAL/TRIO domain and binds several lipids in a large-scale study biological_process phosphatidylcholine binding|phosphatidylinositol transporter activity|phosphatidylinositol binding|phosphatidylcholine transporter activity nucleus
YCR063W YCR063W BUD31 hom Verified 1.50521213533739 0.066134773097305 no 427 0.0528833108703278 285 NA FT CELL CYCLE|RNA PROCESSING|CELL DIVISION NUCLEUS Component of the SF3b subcomplex of the U2 snRNP; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; facilitates passage through G1/S Start, but is not required for G2/M transition or exit from mitosis RNA splicing|mRNA splicing, via spliceosome|cellular bud site selection molecular_function U2 snRNP|nucleus
YEL015W YEL015W EDC3 hom Verified 1.50400765805656 0.0662896974626853 no 428 0.0763692452591327 311 NA FT PROTEIN COMPLEX ORG/BIOGENESIS Non-essential conserved protein with a role in mRNA decapping; specifically affects the function of the decapping enzyme Dcp1p; localizes to cytoplasmic mRNA processing bodies; forms cytoplasmic foci upon DNA replication stress deadenylation-independent decapping of nuclear-transcribed mRNA|cytoplasmic mRNA processing body assembly molecular_function cytoplasmic mRNA processing body
YCL050C YCL050C APA1 hom Verified 1.50330953260293 0.06637962153977 no 429 0.0639386769215934 262 NA FT NUCLEOTIDE METABOLISM NUCLEUS AP4A phosphorylase; bifunctional diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase and ADP sulfurylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; catalyzes phosphorolysis of dinucleoside oligophosphates, cleaving substrates' alpha/beta-anhydride bond and introducing Pi into the beta-position of the corresponding NDP formed; protein abundance increases under DNA replication stress; APA1 has a paralog, APA2, that arose from the whole genome duplication nucleotide biosynthetic process|nucleoside catabolic process bis(5'-nucleosyl)-tetraphosphatase activity|sulfate adenylyltransferase (ADP) activity nucleus|cytoplasm
YOL029C_p YOL029C YOL029C hom Uncharacterized 1.50252202644822 0.0664811718928892 no 430 0.0609089765206014 294 NA Putative protein of unknown function; identified as interacting with Hsc82p and Hsp82p in high-throughput two-hybrid screens biological_process molecular_function cellular_component
YLR267W_p YLR267W BOP2 hom Uncharacterized 1.50058361881456 0.0667316454441772 no 431 0.0300729940604839 147 NA Protein of unknown function biological_process molecular_function cellular_component
YKR013W YKR013W PRY2 hom Verified 1.49877633671557 0.0669658326948447 no 432 0.0917856405874389 376 NA Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY1; may be involved in detoxification of hydrophobic compounds; PRY2 has a paralog, PRY1, that arose from the whole genome duplication biological_process molecular_function extracellular region|fungal-type vacuole
YPR116W YPR116W RRG8 hom Verified 1.49185292420304 0.0678688530347496 no 433 0.0697658376985791 288 NA FT MITOCHONDRION ORGANIZATION MITOCHONDRION Putative protein of unknown function, required for mitochondrial genome maintenance; null mutation results in a decrease in plasma membrane electron transport mitochondrial genome maintenance molecular_function mitochondrion
YLR135W YLR135W SLX4 hom Verified 1.48949217760642 0.0681789058411085 no 434 0.0556730424623698 195 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Endonuclease involved in processing DNA; acts during recombination and repair; cleaves branched structures in a complex with Slx1p; involved interstrand cross-link repair and in Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during DSBR via single-strand annealing; relative distribution to nuclear foci increases upon DNA replication stress double-strand break repair via single-strand annealing, removal of nonhomologous ends|DNA replication|response to DNA damage stimulus|DNA-dependent DNA replication 5'-flap endonuclease activity Slx1-Slx4 complex|nucleus
YOR008C-A_p YOR008C-A YOR008C-A hom Uncharacterized 1.48897683691417 0.0682467341736503 no 435 0.054568732779484 219 NA Putative protein of unknown function, includes a potential transmembrane domain; deletion results in slightly lengthened telomeres biological_process molecular_function cellular_component
YOR371C YOR371C GPB1 hom Verified 1.48871623897172 0.0682810534858182 no 436 0.0609807894030197 272 NA FT SIGNALING|PROTEOLYSIS PLASMA MEMBRANE Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; promotes ubiquitin-dependent proteolysis of Ira2p; regulated by G-alpha protein Gpa2p; GPB1 has a paralog, GPB2, that arose from the whole genome duplication positive regulation of Ras protein signal transduction|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of phosphorylation|signal transduction|glucose mediated signaling pathway|pseudohyphal growth|invasive growth in response to glucose limitation|negative regulation of Ras protein signal transduction|protein polyubiquitination cAMP-dependent protein kinase inhibitor activity|signal transducer activity|GTPase activating protein binding plasma membrane|cytoplasm
YAL027W YAL027W SAW1 hom Verified 1.48794482094756 0.0683827230537677 no 437 0.0427561039632335 225 NA FT RESPONSE TO DNA DAMAGE NUCLEUS 5'- and 3'-flap DNA binding protein; stimulates the endonuclease activity of Rad1/Rad10p; involved in Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during double-strand break repair via single-strand annealing; green fluorescent protein (GFP)-fusion protein localizes to the nucleus double-strand break repair via single-strand annealing, removal of nonhomologous ends molecular_function nucleus
YFL015C_d YFL015C YFL015C hom Dubious 1.48763138604485 0.0684240657776963 no 438 0.0594781302891282 245 NA Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene Unknown Unknown Unknown
YPR158W YPR158W CUR1 hom Verified 1.48633008386413 0.0685959165364974 no 439 0.0799490886766564 373 NA FT NUCLEUS Sorting factor, central regulator of spatial protein quality control; physically and functionally interacts with chaperones to promote sorting and deposition of misfolded proteins into cytosolic compartments; involved in destabilization of [URE3] prions; CUR1 has a paralog, BTN2, that arose from the whole genome duplication cellular response to stress|protein localization to nucleus chaperone binding nucleus
YLR165C YLR165C PUS5 hom Verified 1.48563018864124 0.0686884826982505 no 440 0.0734914391282596 306 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS MITOCHONDRION Pseudouridine synthase, catalyzes only the formation of pseudouridine (Psi)-2819 in mitochondrial 21S rRNA; not essential for viability rRNA modification|pseudouridine synthesis pseudouridylate synthase activity mitochondrion
YDR008C_d YDR008C YDR008C hom Dubious 1.48538152043 0.0687213940346865 no 441 0.234020197884006 909 NA FF Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YNL128W YNL128W TEP1 hom Verified 1.48503543756926 0.0687672184753652 no 442 0.0550981999194497 255 NA FT CELL WALL ORG/BIOGENESIS PTEN homolog with no demonstrated inositol lipid phosphatase activity; plays a role in normal sporulation; homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 and fission yeast ptn1 ascospore wall assembly|phosphatidylinositol dephosphorylation molecular_function cytoplasm
YDR420W YDR420W HKR1 hom Verified 1.47773533274539 0.0697393166246005 no 443 0.0475105568063175 209 NA FT CELL CYCLE|SIGNALING|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Mucin family member that functions as an osmosensor in the Sho1p-mediated HOG pathway with Msb2p; proposed to be a negative regulator of filamentous growth; mutant displays defects in beta-1,3 glucan synthesis and bud site selection (1->3)-beta-D-glucan biosynthetic process|fungal-type cell wall organization|osmosensory signaling pathway via Sho1 osmosensor|hyperosmotic response|cellular bud site selection osmosensor activity site of polarized growth|plasma membrane
YGR256W YGR256W GND2 hom Verified 1.47589939354545 0.0699854511716754 no 444 0.0578948085520075 290 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS 6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone; GND2 has a paralog, GND1, that arose from the whole genome duplication pentose-phosphate shunt, oxidative branch phosphogluconate dehydrogenase (decarboxylating) activity cytosol|plasma membrane
YNL047C YNL047C SLM2 hom Verified 1.4747541652347 0.0701393239693926 no 445 0.0509382466584236 234 NA FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|SIGNALING|CYTOSKELETON ORGANIZATION PLASMA MEMBRANE Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; SLM2 has a paralog, SLM1, that arose from the whole genome duplication eisosome assembly|TOR signaling cascade|regulation of cell growth|actin filament bundle assembly|endosomal transport|establishment or maintenance of actin cytoskeleton polarity|actin cytoskeleton organization phosphatidylinositol binding plasma membrane
YDR451C YDR451C YHP1 hom Verified 1.47380584630452 0.0702669368885344 no 446 0.117546156788061 464 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE NUCLEUS|CHROMOSOME Homeobox transcriptional repressor; binds Mcm1p and early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval; YHP1 has a paralog, YOX1, that arose from the whole genome duplication negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription involved in G1 phase of mitotic cell cycle RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription nuclear chromatin|nucleus
YOL129W YOL129W VPS68 hom Verified 1.47181953742739 0.0705348081255366 no 447 0.0808753705302645 378 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT MITOCHONDRION Vacuolar membrane protein of unknown function involved in vacuolar protein sorting; also detected in the mitochondria late endosome to vacuole transport via multivesicular body sorting pathway|protein targeting to vacuole molecular_function Vps55/Vps68 complex|mitochondrion|fungal-type vacuole membrane|integral to membrane
YDL088C YDL088C ASM4 hom Verified 1.47148254739614 0.0705803319783412 no 448 0.0670901377363992 314 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE FG-nucleoporin component of central core of nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport; induces membrane tubulation, which may contribute to nuclear pore assembly; ASM4 has a paralog, NUP53, that arose from the whole genome duplication nuclear pore organization|mRNA export from nucleus in response to heat stress|mitotic cell cycle spindle assembly checkpoint nucleocytoplasmic transporter activity|phospholipid binding|single-stranded DNA binding nuclear pore central transport channel|integral to membrane|nuclear pore
YPL049C YPL049C DIG1 hom Verified 1.47101680907821 0.0706432855562603 no 449 0.089893908290861 386 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p negative regulation of transcription from RNA polymerase II promoter by pheromones|Unknown DNA binding|transcription factor binding nucleus
YCR031C YCR031C RPS14A hom Verified 1.47059950250595 0.0706997292909985 no 450 0.0665461394843502 360 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION NUCLEUS RIBOSOME Protein component of the small (40S) ribosomal subunit; required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; homologous to mammalian ribosomal protein S14 and bacterial S11; RPS14A has a paralog, RPS14B, that arose from the whole genome duplication cytoplasmic translation|ribosomal small subunit assembly|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome|mRNA binding small-subunit processome|cytosolic small ribosomal subunit|90S preribosome
YBL060W YBL060W YEL1 hom Verified 1.46721139492432 0.0711592790479318 no 451 0.0793738260534091 323 NA FT PROTEIN LOCALIZATION|LIPID METABOLISM|SIGNALING SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Guanine nucleotide exchange factor specific for Arf3p; localized to the bud neck and tip; required for localization of Arf3p to the bud neck and tip positive regulation of phosphatidylinositol biosynthetic process|protein localization|actin cortical patch localization ARF guanyl-nucleotide exchange factor activity cellular bud neck|cellular bud tip|cytoplasm
YHL009C YHL009C YAP3 hom Verified 1.46586597013428 0.0713424021784796 no 452 0.0759594602122665 325 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Basic leucine zipper (bZIP) transcription factor regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nucleus
YHR001W-A YHR001W-A QCR10 hom Verified 1.46154300209867 0.0719332416954509 no 453 0.059047395550354 282 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Subunit of the ubiqunol-cytochrome c oxidoreductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration ubiquinol-cytochrome-c reductase activity mitochondrion|mitochondrial respiratory chain complex III
YDR176W YDR176W NGG1 hom Verified 1.45652317486114 0.0726240239602814 no 454 0.106976918145586 485 NA FF|FT CHROMATIN ORGANIZATION NUCLEUS HISTONE ACETYLTRANSFERASE Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA complex, and the SLIK complex histone acetylation|chromatin modification histone acetyltransferase activity|transcription cofactor activity SLIK (SAGA-like) complex|Ada2/Gcn5/Ada3 transcription activator complex|SAGA complex
YPR065W YPR065W ROX1 hom Verified 1.45526638957056 0.0727977638188941 no 455 0.077194882750469 362 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS|CHROMOSOME Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter in response to stress RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|DNA binding, bending|sequence-specific DNA binding|RNA polymerase II transcription factor recruiting transcription factor activity nuclear chromatin
YGR273C_p YGR273C YGR273C hom Uncharacterized 1.45339699938595 0.0730567795616146 no 456 0.0792311933331878 352 NA Putative protein of unknown function; expression downregulated by treatment with 8-methoxypsoralen plus UVA irradiation; YGR273C is not an essential gene biological_process molecular_function cellular_component
YKL138C YKL138C MRPL31 hom Verified 1.45195636795061 0.0732568688246983 no 457 0.0957029101565626 382 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrial large ribosomal subunit
YIL117C YIL117C PRM5 hom Verified 1.45053059595283 0.0734553067708409 no 458 0.0622713269553192 257 NA Pheromone-regulated protein, predicted to have 1 transmembrane segment; induced during cell integrity signaling biological_process molecular_function integral to membrane
YLL018C-A YLL018C-A COX19 hom Verified 1.44881501262025 0.0736946250599484 no 459 0.0893160168375626 325 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS MITOCHONDRION Protein required for cytochrome c oxidase assembly, located in the cytosol and mitochondrial intermembrane space; putative copper metallochaperone that delivers copper to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs mitochondrial respiratory chain complex IV assembly|metal ion transport copper ion binding|copper chaperone activity cytosol|mitochondrial intermembrane space
YKL086W YKL086W SRX1 hom Verified 1.44836289487247 0.0737577931423022 no 460 0.0658341861511377 276 NA FT OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS NUCLEUS Sulfiredoxin; contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxin Tsa1p, which is formed upon exposure to oxidants; conserved in higher eukaryotes; protein abundance increases in response to DNA replication stress cellular response to oxidative stress sulfiredoxin activity nucleus|cytoplasm
YML058W YML058W SML1 hom Verified 1.44485269560801 0.0742496329436691 no 461 0.0416536080968089 187 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION NUCLEUS Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase mitochondrion organization|response to DNA damage stimulus enzyme inhibitor activity nucleus|cytoplasm
YKL130C YKL130C SHE2 hom Verified 1.44472565714014 0.074267480088155 no 462 0.0493439221817492 220 NA FT RNA LOCALIZATION NUCLEUS|SITE OF POLARIZED GROWTH RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud mating type switching|intracellular mRNA localization mRNA binding cellular bud tip|cytoplasm
YGR255C YGR255C COQ6 hom Verified 1.44257845688895 0.0745696278296387 no 463 0.0788227431936942 345 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM MITOCHONDRION Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS) ubiquinone biosynthetic process N,N-dimethylaniline monooxygenase activity mitochondrion|mitochondrial inner membrane
YPR199C YPR199C ARR1 hom Verified 1.44254364813459 0.074574533732713 no 464 0.0630276542533003 293 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Transcriptional activator of the basic leucine zipper (bZIP) family, required for transcription of genes involved in resistance to arsenic compounds positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus|cytoplasm
YEL020C_p YEL020C YEL020C hom Uncharacterized 1.44234638527698 0.0746023403714976 no 465 0.0817129049309961 308 NA Protein of unknown function with low sequence identity to Pdc1p; mRNA identified as translated by ribosome profiling data biological_process molecular_function cytoplasm
YGR259C_d YGR259C YGR259C hom Dubious 1.44080046125154 0.074820531560475 no 466 0.0643538280880833 301 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W Unknown Unknown Unknown
YOR065W YOR065W CYT1 hom Verified 1.43970107262573 0.0749759948921467 no 467 0.0611499009340032 238 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex oxidative phosphorylation|mitochondrial electron transport, ubiquinol to cytochrome c electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity mitochondrion|mitochondrial respiratory chain|integral to membrane|mitochondrial inner membrane|mitochondrial respiratory chain complex III
YNL142W YNL142W MEP2 hom Verified 1.43960588507147 0.0749894668401558 no 468 0.0674420186578217 241 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation nitrogen utilization|ammonium transport|pseudohyphal growth ammonium transmembrane transporter activity integral to membrane|plasma membrane
YJL084C YJL084C ALY2 hom Verified 1.4369943366842 0.0753598013738473 no 469 0.0605461946693659 292 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION Alpha arrestin that controls nutrient-mediated intracellular sorting of permease Gap1p; interacts with AP-1 subunit Apl4p; phosphorylated by Npr1p and also by cyclin-CDK complex Pcl7p-Pho85p; promotes endocytosis of plasma membrane proteins; ALY2 has a paralog, ALY1, that arose from the whole genome duplication Unknown|regulation of intracellular transport|ubiquitin-dependent endocytosis protein binding, bridging|ubiquitin protein ligase binding late endosome|cytoplasm|early endosome
YLR085C YLR085C ARP6 hom Verified 1.43699333562657 0.0753599435971206 no 470 0.115757247570369 520 NA FF|FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A chromatin remodeling|histone exchange nucleosome binding Swr1 complex|cytoplasm
YJL089W YJL089W SIP4 hom Verified 1.43502320359496 0.0756402427970923 no 471 0.0826487744707419 356 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS NUCLEUS C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source|positive regulation of gluconeogenesis|positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter|Unknown RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YJR124C_p YJR124C YJR124C hom Uncharacterized 1.43474774392607 0.0756794968435828 no 472 0.0546798032402121 263 NA Putative protein of unknown function; expression induced under calcium shortage biological_process molecular_function integral to membrane
YOR025W YOR025W HST3 hom Verified 1.4334241959484 0.0758683238962621 no 473 0.0735679991724643 313 NA FT KETONE METABOLISM|LIPID METABOLISM|CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism short-chain fatty acid metabolic process|histone deacetylation|chromatin silencing at telomere histone deacetylase activity|DNA binding nucleus
YDR467C_d YDR467C YDR467C hom Dubious 1.42574149680653 0.0769714867907044 no 474 0.0841584662577412 304 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR304C YLR304C ACO1 hom Verified 1.42379845806745 0.0772524111000978 no 475 0.126591748957919 509 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy propionate metabolic process|glutamate biosynthetic process|tricarboxylic acid cycle|mitochondrial genome maintenance|citrate metabolic process double-stranded DNA binding|aconitate hydratase activity|single-stranded DNA binding mitochondrial nucleoid|cytosol|mitochondrion|mitochondrial matrix
YGL211W YGL211W NCS6 hom Verified 1.42362614884087 0.0772773610994979 no 476 0.0823583179246468 343 NA FT RNA PROCESSING MITOCHONDRION Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae tRNA wobble position uridine thiolation|protein urmylation|tRNA wobble uridine modification tRNA binding cytosol|mitochondrion
YJL151C YJL151C SNA3 hom Verified 1.42338655159442 0.0773120644305675 no 477 0.0681020109516228 271 NA FT VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM Protein involved in efficient MVB sorting of proteins to the vacuole; may function as an RSP5 adapter protein for MVB cargos; integral membrane protein localized to vacuolar intralumenal vesicles cellular protein catabolic process|endosome transport via multivesicular body sorting pathway ubiquitin protein ligase binding fungal-type vacuole lumen|integral to membrane
YJL141C YJL141C YAK1 hom Verified 1.41569033216043 0.0784330951011328 no 478 0.0653089865443894 291 NA FT PROTEIN PHOSPHORYLATION NUCLEUS Serine-threonine protein kinase; component of a glucose-sensing system that inhibits growth in response to glucose availability; upon nutrient deprivation Yak1p phosphorylates Pop2p to regulate mRNA deadenylation, the co-repressor Crf1p to inhibit transcription of ribosomal genes, and the stress-responsive transcription factors Hsf1p and Msn2p; nuclear localization negatively regulated by the Ras/PKA signaling pathway in the presence of glucose protein phosphorylation protein serine/threonine kinase activity|protein tyrosine kinase activity|protein kinase activity nucleus|cytoplasm
YCR087W_d YCR087W YCR087W hom Dubious 1.41408356084729 0.0786686846492104 no 479 0.0923577557961607 369 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YCR087C-A; YCR087W is not an essential gene Unknown Unknown Unknown
YOR323C YOR323C PRO2 hom Verified 1.41198317044144 0.078977458309576 no 480 0.177279366118514 717 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS NUCLEUS Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis proline biosynthetic process glutamate-5-semialdehyde dehydrogenase activity nucleus|cytoplasm
YER151C YER151C UBP3 hom Verified 1.41141954399757 0.079060471774069 no 481 0.108481595957377 459 NA FT VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS Ubiquitin-specific protease involved in transport and osmotic response; interacts with Bre5p to co-regulate anterograde and retrograde transport between the ER and Golgi; involved in transcription elongation in response to osmostress through phosphorylation at Ser695 by Hog1p; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin; also has mRNA binding activity; protein abundance increases in response to DNA replication stress protein deubiquitination|ribophagy|regulation of ER to Golgi vesicle-mediated transport|regulation of response to osmotic stress ubiquitin-specific protease activity|mRNA binding cytoplasm
YGL209W YGL209W MIG2 hom Verified 1.41122120099474 0.0790897003465638 no 482 0.0695422054213502 278 NA FT TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS NUCLEUS|MITOCHONDRION Zinc finger transcriptional repressor; cooperates with Mig1p in glucose-induced repression of many genes; under low glucose conditions Mig2p relocalizes to mitochondrion, where it interacts with Ups1p and antagonizes mitochondrial fission factor, Dnm1p, indicative of a role in mitochondrial fusion or regulating morphology; regulates filamentous growth along with Mig2p in response to glucose depletion; MIG2 has a paralog, MIG3, that arose from the whole genome duplication negative regulation of transcription from RNA polymerase II promoter by glucose|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding mitochondrion|nucleus
YDR306C_p YDR306C YDR306C hom Uncharacterized 1.41105716584074 0.0791138793669002 no 483 0.094452725065498 332 NA FT PROTEOLYSIS F-box protein of unknown function; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity|protein binding, bridging SCF ubiquitin ligase complex
YMR243C YMR243C ZRC1 hom Verified 1.40872866916581 0.0794577071168141 no 484 0.0776533949559126 361 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Vacuolar membrane zinc transporter; transports zinc from cytosol to vacuole for storage; also has role in resistance to zinc shock resulting from sudden influx of zinc into cytoplasm; human ortholog SLC30A10 functions as a Mn transporter and mutations in SLC30A10 cause neurotoxic accumulation of Mn in liver and brain; ZRC1 has a paralog, COT1, that arose from the whole genome duplication cobalt ion transport|cellular zinc ion homeostasis|zinc ion transport|glutathione metabolic process zinc ion transmembrane transporter activity|inorganic cation transmembrane transporter activity integral to membrane|fungal-type vacuole
YER143W YER143W DDI1 hom Verified 1.40662474208886 0.0797693461920541 no 485 0.0597586353707051 290 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS PLASMA MEMBRANE DNA damage-inducible v-SNARE binding protein with a role in suppression of protein secretion; may play a role in S-phase checkpoint control; has ubiquitin-associated (UBA), ubiquitin-like (UBL), and retroviral-like proteinase (RVP) domains vesicle-mediated transport|protein secretion|ubiquitin-dependent protein catabolic process ubiquitin binding|SNARE binding|aspartic-type endopeptidase activity plasma membrane
YLR228C YLR228C ECM22 hom Verified 1.40457294250574 0.0800741535969181 no 486 0.0690724210417882 283 NA FT TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM NUCLEUS Sterol regulatory element binding protein; regulates transcription of sterol biosynthetic genes; contains Zn[2]-Cys[6] binuclear cluster; relocates from intracellular membranes to perinuclear foci on sterol depletion; ECM22 has a paralog, UPC2, that arose from the whole genome duplication positive regulation of ergosterol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus|membrane|perinuclear region of cytoplasm
YDR152W YDR152W GIR2 hom Verified 1.40074923987261 0.0806445362721607 no 487 0.0817870630897835 359 NA FT TRANSLATION Highly-acidic cytoplasmic RWD domain-containing protein of unknown function; forms a complex with Rbg2p; interacts with Rbg1p and Gcn1p; associates with translating ribosomes; putative intrinsically unstructured protein cytoplasmic translation molecular_function polysome|cytoplasm
YJL201W YJL201W ECM25 hom Verified 1.39807955197675 0.0810445897677993 no 488 0.0776471861903036 339 NA FT SIGNALING|CELL WALL ORG/BIOGENESIS Non-essential protein of unknown function; promoter contains a consensus binding sequence for factor Abf1p fungal-type cell wall organization|filamentous growth molecular_function cytoplasm
YKR017C YKR017C HEL1 hom Verified 1.39747568314344 0.0811352870469359 no 489 0.0831266452904178 349 NA RING finger ubiquitin ligase (E3); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU) biological_process molecular_function cellular_component
YLR081W YLR081W GAL2 hom Verified 1.39617158220281 0.0813314160362948 no 490 0.0697289495292131 303 NA FT CARBOHYDRATE METABOLISM PLASMA MEMBRANE Galactose permease, required for utilization of galactose; also able to transport glucose galactose transport|galactose metabolic process galactose transmembrane transporter activity|glucose transmembrane transporter activity integral to membrane|plasma membrane
YFR044C YFR044C DUG1 hom Verified 1.39529685747053 0.0814631696658681 no 491 0.0860890998901705 357 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|PROTEOLYSIS MITOCHONDRION Cys-Gly metallo-di-peptidase; forms a complex with Dug2p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p) glutathione catabolic process metallodipeptidase activity|omega peptidase activity mitochondrion|ribosome|cytoplasm
YGL256W YGL256W ADH4 hom Verified 1.39242781547102 0.0818964431529912 no 492 0.0666748708844142 336 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Alcohol dehydrogenase isoenzyme type IV, dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency fermentation|amino acid catabolic process to alcohol via Ehrlich pathway alcohol dehydrogenase (NAD) activity mitochondrion
YKR029C YKR029C SET3 hom Verified 1.39074283968662 0.0821517109521886 no 493 0.0866530186144994 372 NA FT CELL CYCLE|CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Defining member of the SET3 histone deacetylase complex which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains; SET3 has a paralog, SET4, that arose from the whole genome duplication negative regulation of meiosis|regulation of transcription, DNA-dependent|histone deacetylation methylated histone residue binding Rpd3L-Expanded complex|Set3 complex
YJL037W YJL037W IRC18 hom Verified 1.39003904667465 0.0822585103506848 no 494 0.0863344581776789 415 NA Putative protein of unknown function; expression induced in respiratory-deficient cells and in carbon-limited chemostat cultures; similar to adjacent ORF, YJL038C; null mutant displays increased levels of spontaneous Rad52p foci biological_process molecular_function cellular_component
YLR037C YLR037C PAU23 hom Verified 1.38925530448054 0.0823775649239147 no 495 0.0831002587890624 352 NA FT CELL WALL ORG/BIOGENESIS Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth biological_process molecular_function fungal-type cell wall
YGL251C YGL251C HFM1 hom Verified 1.38709329383413 0.0827066583326004 no 496 0.103447017177282 403 NA FT CELL CYCLE NUCLEUS Meiosis specific DNA helicase involved in the conversion of double-stranded breaks to later recombination intermediates and in crossover control; catalyzes the unwinding of Holliday junctions; has ssDNA and dsDNA stimulated ATPase activity meiosis|synapsis|DNA unwinding involved in replication|reciprocal meiotic recombination DNA helicase activity nucleus
YLR171W_d YLR171W YLR171W hom Dubious 1.37961525247058 0.0838525693637826 no 497 0.0918954094468138 420 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGL263W YGL263W COS12 hom Verified 1.37899764864802 0.0839477394361914 no 498 0.0578426921156947 223 NA Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins biological_process molecular_function integral to membrane
YHL044W_p YHL044W YHL044W hom Uncharacterized 1.37699851577978 0.0842563533601985 no 499 0.0691982930122547 331 NA FT PLASMA MEMBRANE Putative integral membrane protein, member of DUP240 gene family; green fluorescent protein (GFP)-fusion protein localizes to the plasma membrane in a punctate pattern biological_process molecular_function plasma membrane
YLR262C-A YLR262C-A TMA7 hom Verified 1.37630913753425 0.0843629725703435 no 500 0.0776413177991492 350 NA FT TRANSLATION NUCLEUS Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin; protein abundance increases in response to DNA replication stress cytoplasmic translation molecular_function nucleus|cytoplasm
YOR112W YOR112W CEX1 hom Verified 1.37550466751788 0.0844875198356039 no 501 0.0855680852691019 350 NA FT RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS Cytoplasmic component of the nuclear aminoacylation-dependent tRNA export pathway; interacts with nuclear pore component Nup116p; copurifies with tRNA export receptors Los1p and Msn5p, as well as eIF-1a and the RAN GTPase Gsp1p tRNA export from nucleus tRNA binding nuclear pore|cytoplasm
YKL011C YKL011C CCE1 hom Verified 1.37365294706474 0.0847747255131902 no 502 0.0935416575252356 394 NA FT MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial cruciform cutting endonuclease, cleaves Holliday junctions formed during recombination of mitochondrial DNA mitochondrial genome maintenance endodeoxyribonuclease activity mitochondrial inner membrane
YBR197C YBR197C YBR197C hom Verified 1.37035894079917 0.0852874412249682 no 503 0.0846743388494805 319 NA FT NUCLEUS Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR197C is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress; YBR197C has a paralog, YPL077C, that arose from the whole genome duplication biological_process molecular_function nucleus|cytoplasm
YKL029C YKL029C MAE1 hom Verified 1.36586618042931 0.0859904847366931 no 504 0.0769846976079332 363 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION Mitochondrial malic enzyme, catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids pyruvate metabolic process|cellular amino acid metabolic process malic enzyme activity mitochondrion
YPL064C YPL064C CWC27 hom Verified 1.36345091537273 0.0863702219670822 no 505 0.099652290193815 379 NA FT RNA PROCESSING NUCLEUS Component of a complex containing Cef1p; putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p; protein abundance increases in response to DNA replication stress biological_process molecular_function U2-type spliceosomal complex
YLR425W YLR425W TUS1 hom Verified 1.36207960761253 0.0865863815809717 no 506 0.130135930280118 524 NA FT SIGNALING|CELL WALL ORG/BIOGENESIS SITE OF POLARIZED GROWTH Guanine nucleotide exchange factor (GEF) that modulate Rho1p activity; involved in the cell integrity signaling pathway; interacts with Rgl1p; localization of Tus1p to the bed neck is regulated by Rgl1p; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate fungal-type cell wall organization|signal transduction Rho guanyl-nucleotide exchange factor activity incipient cellular bud site|cellular bud neck
YKL044W_p YKL044W YKL044W hom Uncharacterized 1.36156119487489 0.086668204369203 no 507 0.071719013790767 313 NA Protein of unknown function; mRNA identified as translated by ribosome profiling data biological_process molecular_function cellular_component
YNR030W YNR030W ALG12 hom Verified 1.36090386526442 0.0867720359389451 no 508 0.109897066085484 386 NA FT LIPID METABOLISM|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Alpha-1,6-mannosyltransferase localized to the ER; responsible for the addition of the alpha-1,6 mannose to dolichol-linked Man7GlcNAc2, acts in the dolichol pathway for N-glycosylation dolichol-linked oligosaccharide biosynthetic process|protein glycosylation alpha-1,6-mannosyltransferase activity integral to membrane|endoplasmic reticulum
YHR167W YHR167W THP2 hom Verified 1.35954383360701 0.0869871611698749 no 509 0.0978949302575383 429 NA FT TRANSCRIPTION FROM RNA POL II|RNA LOCALIZATION NUCLEUS Subunit of the THO complex, which connects transcription elongation and mitotic recombination, and of the TREX complex, which is recruited to activated genes and couples transcription to mRNA export; involved in telomere maintenance mRNA export from nucleus|transcription elongation from RNA polymerase II promoter|DNA recombination nucleic acid binding THO complex part of transcription export complex|nucleoplasmic THO complex
YJL205C YJL205C NCE101 hom Verified 1.35922406738454 0.0870377985115563 no 510 0.0740147182591535 326 NA FT PROTEIN LOCALIZATION Protein of unknown function, involved in secretion of proteins that lack classical secretory signal sequences protein secretion molecular_function cellular_component
YOR188W YOR188W MSB1 hom Verified 1.35787158072383 0.0872522182704789 no 511 0.117307632562909 493 NA FT MITOCHONDRION|SITE OF POLARIZED GROWTH Protein of unknown function; may be involved in positive regulation of 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4; potential Cdc28p substrate; relocalizes from bud neck to cytoplasm upon DNA replication stress establishment of cell polarity molecular_function mitochondrion|cellular bud neck|cellular bud tip
YDR509W_d YDR509W YDR509W hom Dubious 1.35559311071365 0.0876143325199192 no 512 0.090592205105319 399 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOR136W YOR136W IDH2 hom Verified 1.35539016583572 0.0876466405911521 no 513 0.114675686942824 465 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylated glutamate biosynthetic process|isocitrate metabolic process|tricarboxylic acid cycle isocitrate dehydrogenase (NAD+) activity mitochondrial isocitrate dehydrogenase complex (NAD+)|mitochondrion|mitochondrial matrix
YLR092W YLR092W SUL2 hom Verified 1.3540914700161 0.0878535986188239 no 514 0.0811585016100035 328 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates sulfate transport sulfate transmembrane transporter activity integral to membrane|plasma membrane
YIL067C_p YIL067C YIL067C hom Uncharacterized 1.35259865197813 0.0880919416706949 no 515 0.0910253304066579 365 NA Uncharacterized protein of unknown function biological_process molecular_function integral to membrane|fungal-type vacuole
YLR351C YLR351C NIT3 hom Verified 1.35222073134176 0.0881523568086291 no 516 0.0707870392492065 292 NA FT MITOCHONDRION Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member biological_process hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds mitochondrion|cytoplasm
YPL244C YPL244C HUT1 hom Verified 1.35179568370424 0.0882203426608084 no 517 0.0858623432841402 352 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein with a role in UDP-galactose transport to the Golgi lumen, has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1 UDP-galactose transport|UDP-glucose transport UDP-galactose transmembrane transporter activity integral to membrane
YGL232W YGL232W TAN1 hom Verified 1.35149135912059 0.0882690430103101 no 518 0.0929398541846347 356 NA FT RNA PROCESSING NUCLEUS Putative tRNA acetyltransferase; RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA; protein abundance increases in response to DNA replication stress tRNA modification RNA binding nucleus|cytoplasm
YOR233W YOR233W KIN4 hom Verified 1.3513348681041 0.0882940937002958 no 519 0.0732480561852739 329 NA FT CELL CYCLE|PROTEIN PHOSPHORYLATION SITE OF POLARIZED GROWTH|CYTOSKELETON Serine/threonine protein kinase; inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck; KIN4 has a paralog, FRK1, that arose from the whole genome duplication mitotic cell cycle spindle orientation checkpoint|protein phosphorylation protein serine/threonine kinase activity|protein kinase activity cell cortex|spindle pole body|cellular bud neck
YDL128W YDL128W VCX1 hom Verified 1.34942773240342 0.0885998090764701 no 520 0.0585961827139296 243 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Vacuolar membrane antiporter with Ca2+/H+ and K+/H+ exchange activity, involved in control of cytosolic Ca2+ and K+ concentrations; has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter manganese ion transport|cellular calcium ion homeostasis|calcium ion transport|transmembrane transport potassium:hydrogen antiporter activity|calcium:hydrogen antiporter activity fungal-type vacuole membrane|integral to membrane|fungal-type vacuole
YML054C YML054C CYB2 hom Verified 1.34250737249154 0.0897157707703788 no 521 0.0685478395550715 252 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions lactate metabolic process L-lactate dehydrogenase (cytochrome) activity mitochondrion|mitochondrial intermembrane space
YLR121C YLR121C YPS3 hom Verified 1.34087861639538 0.0899799329895102 no 522 0.0917815414359214 361 NA FT CELL WALL ORG/BIOGENESIS|PROTEOLYSIS PLASMA MEMBRANE Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor fungal-type cell wall organization|cellular protein metabolic process aspartic-type endopeptidase activity anchored to plasma membrane|plasma membrane
YHR133C YHR133C NSG1 hom Verified 1.3404446640621 0.0900504116061107 no 523 0.0798230563968405 349 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; homolog of mammalian INSIG proteins; forms foci at the nuclear periphery upon DNA replication stress sterol biosynthetic process unfolded protein binding integral to membrane|endoplasmic reticulum
YML050W YML050W AIM32 hom Verified 1.33563711947449 0.0908339556432739 no 524 0.107808423845387 391 NA Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss biological_process molecular_function cellular_component
YFL054C_p YFL054C YFL054C hom Uncharacterized 1.33246491617596 0.0913537313612347 no 525 0.0829155990992631 298 NA Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol water transport|transmembrane transport water channel activity|glycerol transmembrane transporter activity|transporter activity integral to membrane
YBR290W YBR290W BSD2 hom Verified 1.32581431177436 0.0924506056298544 no 526 0.0988657112340883 437 NA FT PROTEIN LOCALIZATION|ION HOMEOSTASIS|PROTEOLYSIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT ENDOPLASMIC RETICULUM Heavy metal ion homeostasis protein, facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded, controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification metal ion transport|ubiquitin-dependent protein catabolic process|protein targeting to vacuole protein binding fungal-type vacuole membrane|integral to membrane|endoplasmic reticulum
YPL078C YPL078C ATP4 hom Verified 1.32538246485557 0.0925221649744608 no 527 0.0953965774564446 380 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS MITOCHONDRION Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; contributes to the oligomerization of the complex; phosphorylated protein complex oligomerization|ATP synthesis coupled proton transport proton-transporting ATPase activity, rotational mechanism mitochondrion|mitochondrial proton-transporting ATP synthase, stator stalk|integral to membrane
YLR169W_d YLR169W YLR169W hom Dubious 1.32058976470986 0.0933190937357799 no 528 0.0750524648342615 311 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR407W_p YLR407W YLR407W hom Uncharacterized 1.31798163515014 0.0937548978649028 no 529 0.0951864798866827 327 NA Putative protein of unknown function; null mutant displays elongated buds and a large fraction of budded cells have only one nucleus biological_process molecular_function cellular_component
YOL138C YOL138C RTC1 hom Verified 1.31687154077509 0.0939408436978328 no 530 0.0963220367944412 398 NA Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; null mutation suppresses cdc13-1 temperature sensitivity; has N-terminal WD-40 repeats and a C-terminal RING motif biological_process molecular_function ribosome|fungal-type vacuole|Seh1-associated complex|extrinsic to fungal-type vacuolar membrane
YHR030C YHR030C SLT2 hom Verified 1.31424856605928 0.0943812848704377 no 531 0.18667810211093 756 NA FF|FT PROTEIN LOCALIZATION|RNA PROCESSING|SIGNALING|CELL WALL ORG/BIOGENESIS|CELL DIVISION|PROTEIN PHOSPHORYLATION|PEROXISOME ORGANIZATION NUCLEUS|SITE OF POLARIZED GROWTH Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, progression through the cell cycle, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to the phagophore assembly site (PAS); regulated by the PKC1-mediated signaling pathway protein phosphorylation|endoplasmic reticulum unfolded protein response|signal transduction|UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response|fungal-type cell wall organization|peroxisome degradation|regulation of transcription factor import into nucleus|barrier septum assembly|response to acid|regulation of cell size MAP kinase activity|protein serine/threonine kinase activity|protein kinase activity nucleus|cytoplasm|cellular bud tip
YLR360W YLR360W VPS38 hom Verified 1.31250584960249 0.0946747568223171 no 532 0.0841696048656336 316 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT GOLGI APPARATUS Part of a Vps34p phosphatidylinositol 3-kinase complex that functions in carboxypeptidase Y (CPY) sorting; binds Vps30p and Vps34p to promote production of phosphatidylinositol 3-phosphate (PtdIns3P) which stimulates kinase activity; required for overflow degradation of misfolded proteins when ERAD is saturated ER-associated protein catabolic process|late endosome to vacuole transport molecular_function phosphatidylinositol 3-kinase complex II
YDL077C YDL077C VAM6 hom Verified 1.30897632252317 0.0952711856460444 no 533 0.150556436717291 553 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p regulation of SNARE complex assembly|regulation of vacuole fusion, non-autophagic|piecemeal microautophagy of nucleus|vesicle-mediated transport|vacuole organization|vacuole fusion, non-autophagic Rab guanyl-nucleotide exchange factor activity|phosphatidylinositol binding fungal-type vacuole membrane|HOPS complex|fungal-type vacuole
YDR438W YDR438W THI74 hom Verified 1.30758511325965 0.0955070344473921 no 534 0.101597531856913 389 NA FT MITOCHONDRION Mitochondrial transporter repressible by thiamine; THI74 has a paralog, YML018C, that arose from the whole genome duplication biological_process molecular_function mitochondrion|integral to membrane
YPR096C YPR096C YPR096C hom Verified 1.30702725602189 0.0956017274236528 no 535 0.0779757737516076 300 NA Protein of unknown function that may interact with ribosomes, based on co-purification experiments biological_process molecular_function ribosome
YPR003C_p YPR003C YPR003C hom Uncharacterized 1.30686069238824 0.0956300140071891 no 536 0.106957010621075 390 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Putative sulfate permease; physically interacts with Hsp82p; green fluorescent protein (GFP)-fusion protein localizes to the ER; YPR003C is not an essential gene biological_process molecular_function integral to membrane|endoplasmic reticulum
YJR096W YJR096W YJR096W hom Verified 1.3068098352181 0.0956386520271195 no 537 0.0854652763684998 329 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS NUCLEUS Putative xylose and arabinose reductase; member of the aldo-keto reductase (AKR) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS cellular response to oxidative stress|D-xylose catabolic process|arabinose catabolic process alditol:NADP+ 1-oxidoreductase activity|aldo-keto reductase (NADP) activity nucleus|cytoplasm
YJR036C YJR036C HUL4 hom Verified 1.30648781045323 0.0956933608148017 no 538 0.099396823787154 375 NA FT PROTEOLYSIS NUCLEUS Protein with similarity to hect domain E3 ubiquitin-protein ligases; not essential for viability; found in association with Trf4 in TRAMP complex protein ubiquitination ubiquitin-protein ligase activity TRAMP complex
YMR316W YMR316W DIA1 hom Verified 1.30603705462777 0.0957699783896715 no 539 0.110693108570485 427 NA Protein of unknown function, involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern pseudohyphal growth|invasive growth in response to glucose limitation molecular_function cytoplasm
YDR226W YDR226W ADK1 hom Verified 1.30591555632056 0.0957906378789332 no 540 0.10797734643815 466 NA FT NUCLEOTIDE METABOLISM MITOCHONDRION Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence; protein abundance increases in response to DNA replication stress ADP biosynthetic process|DNA replication initiation|nucleotide metabolic process adenylate kinase activity mitochondrion|mitochondrial intermembrane space|cytoplasm
YGL056C YGL056C SDS23 hom Verified 1.30548798986642 0.0958633670558124 no 541 0.0985616827308279 386 NA FT CELL DIVISION NUCLEUS One of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; involved in cell separation during budding; SDS23 has a paralog, SDS24, that arose from the whole genome duplication cytokinetic cell separation molecular_function nucleus|cytoplasm
YNR052C YNR052C POP2 hom Verified 1.3011119105713 0.0966100757253825 no 542 0.169173500982965 628 NA FF|FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS|SITE OF POLARIZED GROWTH RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|nuclear-transcribed mRNA poly(A) tail shortening|transcription elongation from RNA polymerase II promoter 3'-5'-exoribonuclease activity CCR4-NOT core complex|mating projection tip|cytoplasmic mRNA processing body|cytoplasm
YHR156C YHR156C LIN1 hom Verified 1.30030457390159 0.0967483005174468 no 543 0.0982597090567304 389 NA FT NUCLEUS|CHROMOSOME Non-essential component of U5 snRNP; nuclear protein; physically interacts with Irr1p of cohesin complex; may link together proteins involved in chromosome segregation, mRNA splicing and DNA replication biological_process protein binding chromatin|nucleus|U4/U6 x U5 tri-snRNP complex|U5 snRNP
YLR438W YLR438W CAR2 hom Verified 1.29878252805992 0.0970092861792441 no 544 0.0980646619291652 380 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS L-ornithine transaminase (OTAse); catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive; protein abundance increases in response to DNA replication stress ornithine metabolic process|arginine catabolic process ornithine-oxo-acid transaminase activity cytosol|nucleus|cytoplasm
YFR024C-A YFR024C-A LSB3 hom Verified 1.29325253749094 0.0979618651374051 no 545 0.0882268854529726 344 NA FT MITOCHONDRION|SITE OF POLARIZED GROWTH Protein containing a C-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein abundance increases in response to DNA replication stress; LSB3 has a paralog, YSC84, that arose from the whole genome duplication actin cortical patch localization molecular_function mitochondrion|cellular bud neck|cytoplasm
YHR136C YHR136C SPL2 hom Verified 1.29266778607084 0.0980629919521123 no 546 0.106255850275827 416 NA Protein with similarity to cyclin-dependent kinase inhibitors; downregulates low-affinity phosphate transport during phosphate limitation; overproduction suppresses a plc1 null mutation; GFP-fusion protein localizes to the cytoplasm response to temperature stimulus enzyme inhibitor activity cytoplasm
YLR315W YLR315W NKP2 hom Verified 1.29136039192686 0.0982893691314834 no 547 0.133355330544941 437 NA FT CELL CYCLE|CELL DIVISION NUCLEUS|CHROMOSOME|CYTOSKELETON KINETOCHORE Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2 biological_process molecular_function spindle pole body|kinetochore
YJR056C YJR056C YJR056C hom Verified 1.2909565872566 0.0983593657980385 no 548 0.0563373415438656 253 NA FT NUCLEUS Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress biological_process molecular_function nucleus|cytoplasm
YOR251C YOR251C TUM1 hom Verified 1.2902230522689 0.0984866122453902 no 549 0.0701222857799902 324 NA FT RNA PROCESSING MITOCHONDRION Rhodanese domain sulfur transferase, accepts persulfite from Nfs1p and transfers it to Uba4p in the pathway for 2-thiolation of the wobble uridine base of tRNAs; also stimulates sulfur transfer by Nfs1p; may be mitochondrially localized tRNA wobble position uridine thiolation|tRNA wobble uridine modification thiosulfate sulfurtransferase activity cytoplasm
YAL020C YAL020C ATS1 hom Verified 1.28980778250939 0.0985587025753161 no 550 0.106200389763472 451 NA FT RNA PROCESSING|CELL DIVISION|CYTOSKELETON ORGANIZATION Protein required, with Elongator complex, Kti11p, and Kti12p, for modification of wobble nucleosides in tRNA; has a potential role in regulatory interactions between microtubules and the cell cycle microtubule-based process|budding cell bud growth|microtubule cytoskeleton organization|tRNA wobble uridine modification molecular_function cytoplasm
YLR461W YLR461W PAU4 hom Verified 1.28839912819902 0.0988035310348261 no 551 0.103375845074213 397 NA Member of the seripauperin multigene family encoded mainly in subtelomeric regions; active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme biological_process molecular_function cellular_component
YMR319C YMR319C FET4 hom Verified 1.28718521082761 0.0990148703725929 no 552 0.165829503048526 621 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Low-affinity Fe(II) transporter of the plasma membrane intracellular copper ion transport|zinc ion transport|low-affinity iron ion transport|copper ion import copper ion transmembrane transporter activity|iron ion transmembrane transporter activity integral to membrane|plasma membrane|integral to plasma membrane
YKR052C YKR052C MRS4 hom Verified 1.28331492446512 0.0996908830194335 no 553 0.0835607146969484 363 NA FT RNA PROCESSING|ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Iron transporter of the mitochondrial carrier family; mediates Fe2+ transport across the inner mitochondrial membrane; active under low-iron conditions; may transport other cations; protein abundance increases in response to DNA replication stress; MRS4 has a paralog, MRS3, that arose from the whole genome duplication mitochondrial iron ion transport|RNA splicing iron ion transmembrane transporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YLR418C YLR418C CDC73 hom Verified 1.28324551284135 0.0997030376686743 no 554 0.195990110905829 700 NA FF|FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION NUCLEUS|CHROMOSOME RNA POL II, HOLOENZYME Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; protein abundance increases in response to DNA replication stress transcription elongation from RNA polymerase I promoter|negative regulation of DNA recombination|mRNA 3'-end processing|recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex|positive regulation of transcription elongation from RNA polymerase II promoter|Unknown|regulation of transcription-coupled nucleotide-excision repair|transcription elongation from RNA polymerase II promoter chromatin binding|TFIIF-class binding transcription factor activity|RNA polymerase II core binding|RNA polymerase II transcription factor binding transcription factor activity nucleus|transcriptionally active chromatin|Cdc73/Paf1 complex
YLR104W_p YLR104W LCL2 hom Uncharacterized 1.28246248878392 0.0998402277898755 no 555 0.0970436461958555 331 NA FT PROTEOLYSIS Putative protein of unknown function; mutant is deficient in amounts of cell wall mannosylphosphate and has long chronological lifespan; genetic interactions suggest a role in ER-associated protein degradation (ERAD) ER-associated protein catabolic process molecular_function cellular_component
YLR441C YLR441C RPS1A hom Verified 1.28090688252998 0.100113187536876 no 556 0.121278255284595 423 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal protein 10 (rp10) of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1A has a paralog, RPS1B, that arose from the whole genome duplication cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit|90S preribosome
YBR041W YBR041W FAT1 hom Verified 1.27980102091908 0.100307562370505 no 557 0.130496079837846 450 NA FT KETONE METABOLISM|LIPID METABOLISM ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Very long chain fatty acyl-CoA synthetase and long chain fatty acid transporter; activates imported fatty acids with a preference for very long lengths (C20-C26); has a separate function in the transport of long chain fatty acids very long-chain fatty acid metabolic process|long-chain fatty acid transport very long-chain fatty acid-CoA ligase activity|long-chain fatty acid transporter activity intrinsic to internal side of plasma membrane|integral to membrane|endoplasmic reticulum|lipid particle|peroxisome
YDR074W YDR074W TPS2 hom Verified 1.27943162867046 0.100372550951985 no 558 0.169517171589697 579 NA FT CARBOHYDRATE METABOLISM MITOCHONDRION Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex; involved in synthesis of the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; protein abundance increases in response to DNA replication stress trehalose biosynthetic process|response to stress trehalose-phosphatase activity mitochondrion|alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)
YOR034C-A_p YOR034C-A YOR034C-A hom Uncharacterized 1.27280652123487 0.101543353272565 no 559 0.128859239721788 457 NA Putative protein of unknown function; identified by expression profiling and mass spectrometry biological_process molecular_function cellular_component
YDR007W YDR007W TRP1 hom Verified 1.27270098439532 0.101562084096236 no 560 0.263990650612107 969 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA) tryptophan biosynthetic process phosphoribosylanthranilate isomerase activity cytoplasm
YGL213C YGL213C SKI8 hom Verified 1.27265855889268 0.101569614541899 no 561 0.0894482683341331 359 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE NUCLEUS|CHROMOSOME Ski complex component and WD-repeat protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; also required for meiotic double-strand break recombination; null mutants have superkiller phenotype nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|protein complex assembly|nuclear-transcribed mRNA catabolic process, non-stop decay|protein-DNA complex assembly|reciprocal meiotic recombination molecular_function Ski complex|nuclear chromosome
YPL111W YPL111W CAR1 hom Verified 1.27260228102868 0.101579604382657 no 562 0.111168621059018 464 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS|SITE OF POLARIZED GROWTH Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance regulation of ornithine metabolic process|arginine catabolic process to ornithine manganese ion binding|arginase activity|ornithine carbamoyltransferase inhibitor activity|zinc ion binding cytosol|nucleus|mating projection tip|cytoplasm
YPL015C YPL015C HST2 hom Verified 1.27209102702084 0.101670389468215 no 563 0.12207479349423 417 NA FT GENE SILENCING NUCLEUS Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro; contains a nuclear export signal (NES); function regulated by its nuclear export negative regulation of chromatin silencing at telomere|chronological cell aging|chromatin silencing at rDNA|negative regulation of mitotic recombination NAD-dependent histone deacetylase activity cytoplasm
YLR342W-A_p YLR342W-A YLR342W-A hom Uncharacterized 1.27193301563249 0.101698460026659 no 564 0.10556821190621 406 NA Putative protein of unknown function biological_process molecular_function cellular_component
YGR166W YGR166W TRS65 hom Verified 1.26880388897284 0.102255508876096 no 565 0.134336237453225 469 NA FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|CELL WALL ORG/BIOGENESIS GOLGI APPARATUS Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p; involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi; role in cell wall beta-glucan biosynthesis and the stress response intra-Golgi vesicle-mediated transport|protein complex assembly Rab guanyl-nucleotide exchange factor activity TRAPP complex|trans-Golgi network
YIL032C_d YIL032C YIL032C hom Dubious 1.26822096455776 0.10235952616416 no 566 0.116728549717161 405 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YJR090C YJR090C GRR1 hom Verified 1.26570052627196 0.10281015992532 no 567 0.132636431287952 530 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CARBOHYDRATE METABOLISM|PROTEOLYSIS NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON UBIQUITIN LIGASE COMPLEX F-box protein component of the SCF ubiquitin-ligase complex; involved in carbon catabolite repression, glucose-dependent divalent cation transport, high-affinity glucose transport, morphogenesis, and sulfite detoxification SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular response to methylmercury|cell cycle arrest in response to pheromone|G1/S transition of mitotic cell cycle|response to DNA damage stimulus|protein ubiquitination ubiquitin-protein ligase activity|protein binding, bridging cellular bud neck contractile ring|SCF ubiquitin ligase complex|nucleus|cytoplasm
YBR238C YBR238C YBR238C hom Verified 1.26533799085029 0.10287509670379 no 568 0.144124778119125 516 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Mitochondrial membrane protein with similarity to Rmd9p; not required for respiratory growth but causes a synthetic respiratory defect in combination with rmd9 mutations; transcriptionally up-regulated by TOR; deletion increases life span aerobic respiration molecular_function mitochondrion|integral to mitochondrial membrane|cytoplasm
YBR145W YBR145W ADH5 hom Verified 1.26493118213487 0.10294799912114 no 569 0.102526834592826 358 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM NUCLEUS Alcohol dehydrogenase isoenzyme V; involved in ethanol production; ADH5 has a paralog, ADH1, that arose from the whole genome duplication NADH oxidation|ethanol biosynthetic process involved in glucose fermentation to ethanol|amino acid catabolic process to alcohol via Ehrlich pathway alcohol dehydrogenase (NAD) activity nucleus|cytoplasm
YLR404W YLR404W FLD1 hom Verified 1.26261296229619 0.10336415359988 no 570 0.106385378263153 388 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Seipin protein involved in lipid droplet morphology, number, and size; proposed to be involved in lipid metabolism; related to the human BSCL2 which is associated with lipodystrophy lipid particle organization molecular_function integral to membrane|endoplasmic reticulum|cortical endoplasmic reticulum
YLR039C YLR039C RIC1 hom Verified 1.26246977634612 0.103389897565335 no 571 0.207227546342683 669 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes intracellular protein transport|retrograde transport, endosome to Golgi guanyl-nucleotide exchange factor activity nucleus|Ric1p-Rgp1p complex|Golgi membrane|guanyl-nucleotide exchange factor complex
YKR104W YKR104W YKR104W hom Verified 1.26175973620587 0.103517627245141 no 572 0.10153894390404 397 NA FT NUCLEOTIDE METABOLISM Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; contains a stop codon in S288C; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds transport ATPase activity, coupled to transmembrane movement of substances integral to membrane|membrane
YIL088C YIL088C AVT7 hom Verified 1.26158880311621 0.103548393629515 no 573 0.0813242616713256 332 NA FT PLASMA MEMBRANE Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters amino acid transport amino acid transmembrane transporter activity integral to membrane|plasma membrane|fungal-type vacuole
YMR299C YMR299C DYN3 hom Verified 1.25948927824262 0.103926830240993 no 574 0.101494013974251 434 NA FT CYTOSKELETON Dynein light intermediate chain (LIC); localizes with dynein, null mutant is defective in nuclear migration nuclear migration along microtubule motor activity cytoplasmic dynein complex|cytoplasmic microtubule
YMR228W YMR228W MTF1 hom Verified 1.25798629185409 0.104198356933521 no 575 0.0949303318696573 394 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation transcription initiation from mitochondrial promoter mitochondrial RNA polymerase binding promoter specificity activity mitochondrion|mitochondrial DNA-directed RNA polymerase complex|mitochondrial matrix|mitochondrial intermembrane space
YOR225W_d YOR225W YOR225W hom Dubious 1.25438740824544 0.104850613535127 no 576 0.106771828146155 416 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YJR088C YJR088C EMC2 hom Verified 1.25272882109546 0.105152206697088 no 577 0.0784434106745599 347 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-2, fly CG17556, human TTC35 protein folding in endoplasmic reticulum molecular_function ER membrane protein complex|endoplasmic reticulum
YJL190C YJL190C RPS22A hom Verified 1.25189483124713 0.105304094218818 no 578 0.11023212568594 431 NA FT TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22A has a paralog, RPS22B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic small ribosomal subunit
YHR105W YHR105W YPT35 hom Verified 1.24902496209291 0.105827971992346 no 579 0.0945559950387298 377 NA Endosomal protein of unknown function that contains a phox (PX) homology domain and binds to both phosphatidylinositol-3-phosphate (PtdIns(3)P) and proteins involved in ER-Golgi or vesicular transport biological_process phosphatidylinositol-3-phosphate binding endosome
YDR326C YDR326C YSP2 hom Verified 1.24777806114056 0.106056172542815 no 580 0.11230776077773 464 NA FT MITOCHONDRION Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification; YSP2 has a paralog, YHR080C, that arose from the whole genome duplication apoptotic process molecular_function mitochondrion
YDR431W_d YDR431W YDR431W hom Dubious 1.24474786888495 0.106612222052585 no 581 0.0791993834312487 329 NA Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YMR054W YMR054W STV1 hom Verified 1.24354030976181 0.106834398214686 no 582 0.109159311515183 459 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Subunit a of the vacuolar-ATPase V0 domain, one of two isoforms (Stv1p and Vph1p); Stv1p is located in V-ATPase complexes of the Golgi and endosomes while Vph1p is located in V-ATPase complexes of the vacuole vacuolar acidification proton-transporting ATPase activity, rotational mechanism vacuolar proton-transporting V-type ATPase, V0 domain|late endosome|integral to membrane|Golgi apparatus
YLR253W_p YLR253W YLR253W hom Uncharacterized 1.2434678993841 0.106847731450688 no 583 0.107194810870691 407 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; transcription is periodic during the metabolic cycle; YLR253W is not an essential gene biological_process molecular_function mitochondrion
YLR058C YLR058C SHM2 hom Verified 1.23977766587446 0.107528820611392 no 584 0.10228218389676 359 NA FT KETONE METABOLISM|AMINO ACID METABOLISM SITE OF POLARIZED GROWTH Cytosolic serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis one-carbon metabolic process glycine hydroxymethyltransferase activity plasma membrane|mating projection tip|cytoplasm
YGR289C YGR289C MAL11 hom Verified 1.23486073323591 0.108441169772111 no 585 0.126527407433332 499 NA FT CARBOHYDRATE METABOLISM PLASMA MEMBRANE Inducible high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL1 complex locus; broad substrate specificity that includes maltotriose; required for isomaltose utilization trehalose transport|maltose transport|disaccharide catabolic process trehalose transmembrane transporter activity|alpha-glucoside:hydrogen symporter activity|maltose:hydrogen symporter activity integral to membrane|plasma membrane
YBL012C_d YBL012C YBL012C hom Dubious 1.23448985043749 0.108510213223533 no 586 0.108349195384703 440 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YHL026C_p YHL026C YHL026C hom Uncharacterized 1.23410811990818 0.108581309105526 no 587 0.116439482199465 419 NA Putative protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History) biological_process molecular_function cellular_component
YOR177C YOR177C MPC54 hom Verified 1.23025513423875 0.109300789755044 no 588 0.117678739369217 450 NA FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION NUCLEUS|CYTOSKELETON Component of the meiotic outer plaque, a membrane-organizing center which is assembled on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; potential Cdc28p substrate ascospore wall assembly|vesicle docking structural molecule activity spindle pole body
YKR009C YKR009C FOX2 hom Verified 1.22876737298071 0.109579518846091 no 589 0.0754313730440939 313 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities fatty acid beta-oxidation enoyl-CoA hydratase activity|3-hydroxyacyl-CoA dehydrogenase activity peroxisome
YBR084C-A YBR084C-A RPL19A hom Verified 1.22727646542674 0.109859349022675 no 590 0.109305143415474 396 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L19A; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19A has a paralog, RPL19B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YOR324C YOR324C FRT1 hom Verified 1.22465919396172 0.110351827460785 no 591 0.120152987167696 419 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Tail-anchored ER membrane protein of unknown function; substrate of the phosphatase calcineurin; interacts with homolog Frt2p; promotes cell growth in stress conditions, possibly via a role in posttranslational translocation; FRT1 has a paralog, FRT2, that arose from the whole genome duplication response to stress molecular_function endoplasmic reticulum
YDR426C_d YDR426C YDR426C hom Dubious 1.22329382999259 0.110609368368058 no 592 0.0744480377461496 283 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SNX41 Unknown Unknown Unknown
YBL085W YBL085W BOI1 hom Verified 1.22247109744439 0.110764763622037 no 593 0.102444983067747 417 NA FT SIGNALING|CELL DIVISION SITE OF POLARIZED GROWTH Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication cytokinesis, completion of separation|establishment of cell polarity|budding cell apical bud growth|Rho protein signal transduction phospholipid binding site of polarized growth|cellular bud|mating projection tip|cellular bud neck
YLL002W YLL002W RTT109 hom Verified 1.22224117172273 0.110808219256292 no 594 0.117839561722124 429 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS Histone acetyltransferase critical for cell survival in the presence of DNA damage during S phase; acetylates H3-K56 and H3-K9; involved in non-homologous end joining and in regulation of Ty1 transposition; interacts physically with Vps75p negative regulation of transposition, RNA-mediated|histone acetylation|double-strand break repair via nonhomologous end joining|response to DNA damage stimulus|regulation of transcription from RNA polymerase II promoter in response to stress H3 histone acetyltransferase activity nucleus
YEL039C YEL039C CYC7 hom Verified 1.22088130270531 0.111065482341708 no 595 0.132270622605405 490 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; protein abundance increases in response to DNA replication stress; CYC7 has a paralog, CYC1, that arose from the whole genome duplication mitochondrial electron transport, cytochrome c to oxygen|mitochondrial electron transport, ubiquinol to cytochrome c electron carrier activity mitochondrion|mitochondrial intermembrane space
YOL012C YOL012C HTZ1 hom Verified 1.22054131225336 0.111129869290611 no 596 0.133213599832347 556 NA FF|FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin nuclear-transcribed mRNA catabolic process, non-stop decay|regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette chromatin binding nuclear chromatin|chromatin assembly complex
YNL288W YNL288W CAF40 hom Verified 1.21859359082627 0.11149924142451 no 597 0.117012489099309 433 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter molecular_function CCR4-NOT core complex
YER092W YER092W IES5 hom Verified 1.21596499157737 0.111999129161606 no 598 0.125242793957645 525 NA FT NUCLEUS Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions biological_process molecular_function nucleus
YER056C-A YER056C-A RPL34A hom Verified 1.21532677212309 0.11212074244674 no 599 0.0922529527981785 378 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L34A; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34A has a paralog, RPL34B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YKR069W YKR069W MET1 hom Verified 1.21530666795702 0.112124574846448 no 600 0.112572885498916 416 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis siroheme biosynthetic process|methionine biosynthetic process|sulfate assimilation uroporphyrin-III C-methyltransferase activity intracellular
YLR038C YLR038C COX12 hom Verified 1.21251918023482 0.112656852542194 no 601 0.115112786784227 432 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Subunit VIb of cytochrome c oxidase; cytochrome c oxidase is also known as respiratory Complex IV and is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated; easily released from the intermembrane space, suggesting a loose association with Complex IV mitochondrial respiratory chain complex IV assembly cytochrome-c oxidase activity mitochondrion|integral to membrane|mitochondrial respiratory chain complex IV
YPL042C YPL042C SSN3 hom Verified 1.21230761256544 0.112697325467633 no 602 0.153039515697254 553 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS NUCLEUS Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression phosphorylation of RNA polymerase II C-terminal domain|negative regulation of transcription from RNA polymerase II promoter|negative regulation of filamentous growth|protein phosphorylation|protein destabilization|nuclear-transcribed mRNA catabolic process, non-stop decay|positive regulation of transcription from RNA polymerase II promoter by galactose RNA polymerase II carboxy-terminal domain kinase activity|protein kinase activity|cyclin-dependent protein kinase activity mediator complex
YIR009W YIR009W MSL1 hom Verified 1.21139367018773 0.112872282081075 no 603 0.136525873591862 516 NA FT RNA PROCESSING NUCLEUS U2B component of U2 snRNP, involved in splicing, binds the U2 snRNA stem-loop IV in vitro but requires association of Lea1p for in vivo binding; does not contain the conserved C-terminal RNA binding domain found in other family members mRNA splicing, via spliceosome U2 snRNA binding U2 snRNP|U2-type prespliceosome
YIL055C_p YIL055C YIL055C hom Uncharacterized 1.20822429898219 0.113480498797883 no 604 0.113302009109686 397 NA Putative protein of unknown function biological_process molecular_function cellular_component
YMR140W YMR140W SIP5 hom Verified 1.20771132525995 0.113579160117827 no 605 0.104976119957678 388 NA FT RESPONSE TO NUTRIENT LEVELS Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase; forms cytoplasmic foci upon DNA replication stress cellular response to glucose starvation molecular_function cytoplasm
YML034C-A_d YML034C-A YML034C-A hom Dubious 1.20693157286306 0.113729248654899 no 606 0.128569938838072 496 NA Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLL049W YLL049W LDB18 hom Verified 1.20590319180097 0.113927409905646 no 607 0.0962425691246761 366 NA FT CELL CYCLE|CYTOSKELETON ORGANIZATION CYTOSKELETON Component of the dynactin complex, which is required for dynein activity; null mutant exhibits defects in nuclear migration and spindle orientation and has reduced affinity for alcian blue dye; has homology to mammalian dynactin subunit p24 establishment of mitotic spindle orientation molecular_function dynactin complex|cell cortex|spindle pole body|astral microtubule
YGR269W_d YGR269W YGR269W hom Dubious 1.20492484713045 0.114116157763225 no 608 0.11593757564221 435 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF HUA1/YGR268C Unknown Unknown Unknown
YDR139C YDR139C RUB1 hom Verified 1.2047674697427 0.114146540695095 no 609 0.0860025062806051 327 NA Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme) protein neddylation protein tag cytoplasm
YLR068W YLR068W FYV7 hom Verified 1.20143085335812 0.114792056950138 no 610 0.119786386606792 455 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) molecular_function nucleolus|nucleus
YML006C YML006C GIS4 hom Verified 1.1984062460574 0.11537945101555 no 611 0.124345558068965 457 NA FT SIGNALING|ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE CAAX box containing protein of unknown function, proposed to be involved in the RAS/cAMP signaling pathway cellular ion homeostasis|intracellular signal transduction molecular_function plasma membrane
YDL160C-A YDL160C-A MHF2 hom Verified 1.19629048031485 0.115791611201829 no 612 0.12394663015434 470 NA FT RESPONSE TO DNA DAMAGE Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM to stabilize and remodel blocked replication forks and repair damaged DNA; mhf2 srs2 double mutants are MMS hypersensitive; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-X, also known as MHF2 response to DNA damage stimulus molecular_function cellular_component
YDL169C YDL169C UGX2 hom Verified 1.19489309021238 0.116064401457736 no 613 0.113828262800659 424 NA Protein of unknown function, transcript accumulates in response to any combination of stress conditions biological_process molecular_function cellular_component
YDR237W YDR237W MRPL7 hom Verified 1.19303114074472 0.116428588679312 no 614 0.135307947263558 518 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YLR452C YLR452C SST2 hom Verified 1.19185053647598 0.11665992800916 no 615 0.111029140784673 421 NA FT SIGNALING PLASMA MEMBRANE GTPase-activating protein for Gpa1p, regulates desensitization to alpha factor pheromone; also required to prevent receptor-independent signaling of the mating pathway; member of the RGS (regulator of G-protein signaling) family adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|signal transduction GTPase activator activity plasma membrane
YOR265W YOR265W RBL2 hom Verified 1.19172608751356 0.116684332751418 no 616 0.134122518837923 486 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION CYTOSKELETON Protein involved in microtubule morphogenesis; required for protection from excess free beta-tubulin; proposed to be involved the folding of beta-tubulin; similar to mouse beta-tubulin cofactor A; protein abundance increases in response to DNA replication stress tubulin complex assembly|tubulin complex biogenesis tubulin binding|beta-tubulin binding cytoplasm
YCR007C_p YCR007C YCR007C hom Uncharacterized 1.18962609908893 0.117096691564383 no 617 0.13295494174532 441 NA Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene biological_process molecular_function cellular_component
YJL139C YJL139C YUR1 hom Verified 1.18949819683524 0.117121840076746 no 618 0.121498058676641 455 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Mannosyltransferase involved in protein N-glycosylation; member of the KTR1 family; located in the Golgi apparatus; YUR1 has a paralog, KTR2, that arose from the whole genome duplication cell wall mannoprotein biosynthetic process|protein N-linked glycosylation mannosyltransferase activity Golgi apparatus
YHR200W YHR200W RPN10 hom Verified 1.18857457714777 0.117303558453829 no 619 0.118071725567768 470 NA FT PROTEOLYSIS Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein ubiquitin-dependent protein catabolic process structural molecule activity|polyubiquitin binding proteasome complex|proteasome regulatory particle, base subcomplex
YKL073W YKL073W LHS1 hom Verified 1.18839443571267 0.117339023799776 no 620 0.142561139836113 532 NA FT PROTEIN LOCALIZATION|NUCLEOTIDE METABOLISM ENDOPLASMIC RETICULUM Molecular chaperone of the endoplasmic reticulum lumen, involved in polypeptide translocation and folding; nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; regulated by the unfolded protein response pathway posttranslational protein targeting to membrane, translocation|response to unfolded protein unfolded protein binding|adenyl-nucleotide exchange factor activity|ATP binding endoplasmic reticulum lumen
YKR099W YKR099W BAS1 hom Verified 1.18798192082784 0.117420266273497 no 621 0.1217530040278 443 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes positive regulation of transcription from RNA polymerase II promoter core promoter sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|RNA polymerase II transcription factor recruiting transcription factor activity nucleus
YKL026C YKL026C GPX1 hom Verified 1.18752729294175 0.117509848794138 no 622 0.121700142117286 449 NA FT OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress cellular response to oxidative stress|peroxisome organization phospholipid-hydroperoxide glutathione peroxidase activity|glutathione peroxidase activity extrinsic to mitochondrial outer membrane|peroxisomal matrix
YDR539W YDR539W FDC1 hom Verified 1.18739642200207 0.1175356453317 no 623 0.111373291893966 443 NA FT KETONE METABOLISM|COFACTOR METABOLISM PLASMA MEMBRANE Putative phenylacrylic acid decarboxylase; essential for the decarboxylation of aromatic carboxylic acids to the corresponding vinyl derivatives; homolog of E. coli UbiD; GFP-fusion protein localizes to the cytoplasm cinnamic acid catabolic process molecular_function cytoplasm
YFR034C YFR034C PHO4 hom Verified 1.18697210405177 0.117619312051846 no 624 0.154380582816305 557 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS NUCLEUS Basic helix-loop-helix (bHLH) transcription factor of the myc-family; activates transcription cooperatively with Pho2p in response to phosphate limitation; binding to 'CACGTG' motif is regulated by chromatin restriction, competitive binding of Cbf1p to the same DNA binding motif and cooperation with Pho2p,; function is regulated by phosphorylation at multiple sites and by phosphate availability cellular response to phosphate starvation|positive regulation of phosphate metabolic process|phosphate-containing compound metabolic process|chromatin remodeling|positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nucleus|cytoplasm
YOR238W_p YOR238W YOR238W hom Uncharacterized 1.18192052059758 0.118618619403074 no 625 0.088844108351102 349 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm biological_process molecular_function cytoplasm
YIL050W YIL050W PCL7 hom Verified 1.18100226713838 0.11880091133434 no 626 0.0758956565883247 307 NA FT CELL CYCLE|OXIDATION-REDUCTION PROCESS|CELL DIVISION|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Pho85p cyclin of the Pho80p subfamily, forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism, expression is cell-cycle regulated regulation of glycogen catabolic process|regulation of cyclin-dependent protein kinase activity|regulation of protein stability|regulation of glycogen biosynthetic process cyclin-dependent protein kinase regulator activity cyclin-dependent protein kinase holoenzyme complex|nucleus
YFL051C_p YFL051C YFL051C hom Uncharacterized 1.18073142574375 0.118854716614327 no 627 0.0944699589618502 351 NA FT PLASMA MEMBRANE Putative protein of unknown function; YFL051C is not an essential gene biological_process molecular_function cellular_component
YJL161W_p YJL161W FMP33 hom Uncharacterized 1.1799785836904 0.119004366423148 no 628 0.095697845468063 359 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YNL168C_p YNL168C FMP41 hom Uncharacterized 1.17994310958912 0.119011421239513 no 629 0.101323060130913 410 NA FT MITOCHONDRION Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YCR082W YCR082W AHC2 hom Verified 1.17845649852828 0.119307332545187 no 630 0.134815989716411 507 NA FT CHROMATIN ORGANIZATION NUCLEUS HISTONE ACETYLTRANSFERASE Component of the ADA histone acetyltransferase complex; Ach2p and Ach1p are unique to the ADA complex and not shared with the related SAGA and SLIK complexes; may tether Ach1p to the complex histone acetylation histone acetyltransferase activity Ada2/Gcn5/Ada3 transcription activator complex|nucleus|cytoplasm
YLR287C_p YLR287C YLR287C hom Uncharacterized 1.17504331848893 0.119988692802539 no 631 0.104727683785308 365 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR287C is not an essential gene biological_process molecular_function cytoplasm
YMR269W YMR269W TMA23 hom Verified 1.17355785108016 0.120286086048956 no 632 0.120311824885195 479 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS NUCLEUS Nucleolar protein implicated in ribosome biogenesis; deletion extends chronological lifespan ribosomal small subunit biogenesis molecular_function ribosome|nucleolus
YPR020W YPR020W ATP20 hom Verified 1.17264909782248 0.120468275887519 no 633 0.117210395796731 459 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS MITOCHONDRION Subunit g of the mitochondrial F1F0 ATP synthase; reversibly phosphorylated on two residues; unphosphorylated form is required for dimerization of the ATP synthase complex protein oligomerization|cristae formation|protein complex assembly|ATP synthesis coupled proton transport structural molecule activity|proton-transporting ATPase activity, rotational mechanism mitochondrion|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
YDR455C_d YDR455C YDR455C hom Dubious 1.16970046712933 0.121060765052351 no 634 0.165618814372911 644 NA FF Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W Unknown Unknown Unknown
YMR279C YMR279C YMR279C hom Verified 1.16936466891023 0.121128369156663 no 635 0.14075010106508 484 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Putative boron transporter involved in boron efflux and resistance; overexpression mutant but not null mutant displays boron tolerance phenotype; identified as a heat-induced gene in a high-throughout screen; YMR279C is not an essential gene; YMR279C has a paralog, ATR1, that arose from the whole genome duplication borate transmembrane transport borate efflux transmembrane transporter activity integral to membrane
YGR070W YGR070W ROM1 hom Verified 1.16831192893261 0.12134048266456 no 636 0.13214944989705 501 NA FT SIGNALING|NUCLEOTIDE METABOLISM GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP small GTPase mediated signal transduction|activation of Rho GTPase activity Rho guanyl-nucleotide exchange factor activity intracellular
YIL012W_d YIL012W YIL012W hom Dubious 1.16816592459569 0.121369921263379 no 637 0.122555906393795 456 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YFR039C_p YFR039C YFR039C hom Uncharacterized 1.16752356866157 0.121499498012322 no 638 0.0984952739412471 366 NA Putative protein of unknown function; may be involved in response to high salt and changes in carbon source; deletion mutant has decreased spore survival in Drosophila feces biological_process molecular_function cellular_component
YHR078W_p YHR078W YHR078W hom Uncharacterized 1.16619309790266 0.12176819126952 no 639 0.11006538104588 375 NA High osmolarity-regulated gene of unknown function biological_process molecular_function integral to membrane
YDR194W-A_p YDR194W-A YDR194W-A hom Uncharacterized 1.16537884727118 0.121932837848235 no 640 0.144986995682475 504 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YDR076W YDR076W RAD55 hom Verified 1.16441759396761 0.122127410476975 no 641 0.141953710599709 536 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p DNA recombinase assembly|heteroduplex formation|meiotic DNA recombinase assembly|double-strand break repair via single-strand annealing DNA-dependent ATPase activity|protein heterodimerization activity nucleus|Rhp55-Rhp57 complex
YBR042C YBR042C CST26 hom Verified 1.16360384886797 0.122292295461665 no 642 0.112998873212139 453 NA FT LIPID METABOLISM Putative transferase involved in phospholipid biosynthesis; required for incorporation of stearic acid into phosphatidylinositol; affects chromosome stability when overexpressed; CST26 has a paralog, YDR018C, that arose from the whole genome duplication phospholipid biosynthetic process transferase activity, transferring acyl groups lipid particle
YGL140C_p YGL140C YGL140C hom Uncharacterized 1.16286077184286 0.122442997778305 no 643 0.079493464424379 324 NA Putative protein of unknown function; non-essential gene; contains multiple predicted transmembrane domains biological_process molecular_function integral to membrane
YKL190W YKL190W CNB1 hom Verified 1.16150475888182 0.122718344505692 no 644 0.127422534952899 473 NA FF|FT SIGNALING|ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1; protein abundance increases in response to DNA replication stress adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|fungal-type cell wall organization|cellular ion homeostasis calcium-dependent protein serine/threonine phosphatase activity|calcium ion binding calcineurin complex
YLR416C_d YLR416C YLR416C hom Dubious 1.1611352505029 0.122793450682911 no 645 0.115539261975745 408 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YKL174C YKL174C TPO5 hom Verified 1.16062929039796 0.1228963442855 no 646 0.103588673323752 369 NA FT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Protein involved in excretion of putrescine and spermidine; putative polyamine transporter in the Golgi or post-Golgi vesicles polyamine transport polyamine transmembrane transporter activity integral to membrane|Golgi apparatus
YJL121C YJL121C RPE1 hom Verified 1.1592135967995 0.12318456526722 no 647 0.148442044012697 531 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress pentose-phosphate shunt ribulose-phosphate 3-epimerase activity cytosol
YOR311C YOR311C DGK1 hom Verified 1.15886349503461 0.123255915468301 no 648 0.100860743451839 377 NA FT VESICLE-MEDIATED TRANSPORT|KETONE METABOLISM|LIPID METABOLISM ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Diacylglycerol kinase, localized to the endoplasmic reticulum (ER); overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation; contains a CTP transferase domain phosphatidic acid biosynthetic process diacylglycerol kinase activity integral to endoplasmic reticulum membrane|integral to membrane
YKR105C_p YKR105C VBA5 hom Uncharacterized 1.15789671919304 0.123453093277083 no 649 0.12035217784663 458 NA Plasma membrane protein of the Major Facilitator Superfamily (MFS); involved in amino acid uptake and drug sensitivity; similar to Vba3p biological_process molecular_function integral to membrane
YMR254C_d YMR254C YMR254C hom Dubious 1.15711335287945 0.123613025951423 no 650 0.117355364182072 452 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YJL056C YJL056C ZAP1 hom Verified 1.15633309175111 0.123772468843136 no 651 0.210725878693146 717 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS NUCLEUS Zinc-regulated transcription factor; binds to zinc-responsive promoters to induce transcription of certain genes in presence of zinc, represses other genes in low zinc; regulates its own transcription; contains seven zinc-finger domains regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation|positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding RNA polymerase II transcription factor activity|RNA polymerase II regulatory region sequence-specific DNA binding|zinc ion binding nucleus
YOR196C YOR196C LIP5 hom Verified 1.15557121645022 0.123928293546464 no 652 0.144034375287992 569 NA FT KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM MITOCHONDRION Protein involved in biosynthesis of the coenzyme lipoic acid, has similarity to E. coli lipoic acid synthase protein lipoylation lipoate synthase activity mitochondrion
YOR054C YOR054C VHS3 hom Verified 1.15487535835561 0.124070735817795 no 653 0.133948332058681 449 NA FT CELL CYCLE|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|COFACTOR METABOLISM Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis coenzyme A biosynthetic process|cellular monovalent inorganic cation homeostasis phosphopantothenoylcysteine decarboxylase activity|protein phosphatase inhibitor activity phosphopantothenoylcysteine decarboxylase complex
YIL090W YIL090W ICE2 hom Verified 1.15466779017411 0.124113247233482 no 654 0.134329582257345 469 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Integral ER membrane protein with type-III transmembrane domains; required for maintenance of ER zinc homeostasis; necessary for efficient targeting of Trm1p tRNA methyltransferase to inner nuclear membrane; mutations cause defects in cortical ER morphology in both the mother and daughter cells endoplasmic reticulum inheritance molecular_function integral to endoplasmic reticulum membrane|integral to membrane|endoplasmic reticulum
YNL148C YNL148C ALF1 hom Verified 1.15458556806283 0.124130089714763 no 655 0.176321976906168 664 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS NUCLEUS|CYTOSKELETON Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance protein folding|post-chaperonin tubulin folding pathway microtubule binding|alpha-tubulin binding nucleus|cytoplasm
YDL172C_d YDL172C YDL172C hom Dubious 1.15423914316028 0.124201069391202 no 656 0.146926335926973 538 NA Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YEL009C YEL009C GCN4 hom Verified 1.15364821323907 0.124322211692591 no 657 0.244459438956057 893 NA FF|FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|PROTEIN COMPLEX ORG/BIOGENESIS|AMINO ACID METABOLISM|RIBOSOME BIOGENESIS|RESPONSE TO NUTRIENT LEVELS NUCLEUS Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels nitrogen catabolite activation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription initiation from RNA polymerase II promoter|negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to nutrient levels chromatin binding|TFIID-class binding transcription factor activity|sequence-specific DNA binding|RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription factor recruiting transcription factor activity|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription|sequence-specific DNA binding transcription factor activity nucleus
YPR054W YPR054W SMK1 hom Verified 1.15345843882886 0.124361133507241 no 658 0.0954179982826339 422 NA FT SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION MITOCHONDRION Middle sporulation-specific mitogen-activated protein kinase (MAPK) required for production of the outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p ascospore wall assembly|protein phosphorylation|negative regulation of sporulation resulting in formation of a cellular spore MAP kinase activity mitochondrion
YBL066C YBL066C SEF1 hom Verified 1.15245088096021 0.12456792148098 no 659 0.0997248437814203 403 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Putative transcription factor, has homolog in Kluyveromyces lactis biological_process molecular_function cellular_component
YPL038W-A_p YPL038W-A YPL038W-A hom Uncharacterized 1.15199784745486 0.1246609789327 no 660 0.100122450022195 377 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YPL118W YPL118W MRP51 hom Verified 1.15121643149836 0.124821603470167 no 661 0.144458869573638 536 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit; MRP51 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences mitochondrial translational initiation|mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YDR532C YDR532C KRE28 hom Verified 1.14850344647972 0.125380395529202 no 662 0.154018168778151 487 NA FT ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME|CYTOSKELETON KINETOCHORE Subunit of a kinetochore-microtubule binding complex with Spc105p that bridges centromeric heterochromatin and kinetochore MAPs and motors, and is also required for sister chromatid bi-orientation and kinetochore binding of SAC components biological_process molecular_function chromosome, centromeric region|condensed nuclear chromosome kinetochore|spindle pole body
YDR506C YDR506C GMC1 hom Verified 1.14743157217536 0.125601649418423 no 663 0.110370273767779 389 NA FT CELL CYCLE|ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS Protein involved in meiotic progression; mutants are delayed in meiotic nuclear division and are defective in synaptonemal complex assembly; possible membrane-localized protein meiosis|synaptonemal complex organization molecular_function cellular_component
YJL149W YJL149W DAS1 hom Verified 1.14739398236108 0.125609413564989 no 664 0.139366805184321 534 NA FT PROTEOLYSIS UBIQUITIN LIGASE COMPLEX Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity|protein binding, bridging SCF ubiquitin ligase complex
YPL188W YPL188W POS5 hom Verified 1.14706885962819 0.125676581384213 no 665 0.125949561207786 500 NA FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS MITOCHONDRION Mitochondrial NADH kinase, phosphorylates NADH; also phosphorylates NAD(+) with lower specificity; required for the response to oxidative stress cellular response to oxidative stress|NADP biosynthetic process NADH kinase activity mitochondrion|mitochondrial matrix
YDL189W YDL189W RBS1 hom Verified 1.14684348054079 0.12572315764829 no 666 0.113698177196097 410 NA FT CARBOHYDRATE METABOLISM Protein of unknown function, identified as a high copy suppressor of psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization; proposed to bind single-stranded nucleic acids via its R3H domain galactose metabolic process molecular_function cytoplasm
YDR268W YDR268W MSW1 hom Verified 1.14624342592626 0.125847222099913 no 667 0.146065180246009 513 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial tryptophanyl-tRNA synthetase mitochondrial tryptophanyl-tRNA aminoacylation tryptophan-tRNA ligase activity mitochondrion
YLR406C-A_p YLR406C-A YLR406C-A hom Uncharacterized 1.145198300716 0.126063511063572 no 668 0.129738386205296 446 NA Putative protein of unknown function biological_process molecular_function cellular_component
YBR044C YBR044C TCM62 hom Verified 1.14314682125032 0.126488818632494 no 669 0.0733807270968886 332 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; putative chaperone mitochondrial respiratory chain complex II assembly unfolded protein binding mitochondrion|mitochondrial inner membrane
YHL027W YHL027W RIM101 hom Verified 1.142326901605 0.12665908158987 no 670 0.175156034043046 645 NA FF|FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|CELL DIVISION|ION HOMEOSTASIS NUCLEUS Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression as part of adaptation to a alkaline conditions; involved in cell wall assembly; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by alkaline-dependent proteolytic processing which results in removal of the C-terminal tail; similar to A. nidulans PacC meiosis|negative regulation of transcription from RNA polymerase II promoter|fungal-type cell wall biogenesis|cellular response to anoxia|response to pH|ascospore formation|barrier septum assembly|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|sequence-specific DNA binding nucleus
YHR147C YHR147C MRPL6 hom Verified 1.14135818284117 0.12686044949715 no 671 0.149485309818893 540 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YBR187W_p YBR187W GDT1 hom Uncharacterized 1.14101313955987 0.12693222756544 no 672 0.131784324321173 508 NA Putative protein of unknown function; expression is reduced in a gcr1 null mutant; GFP-fusion protein localizes to the vacuole; expression pattern and physical interactions suggest a possible role in ribosome biogenesis biological_process molecular_function integral to membrane|fungal-type vacuole
YGL148W YGL148W ARO2 hom Verified 1.14099029876644 0.126936980048011 no 673 0.21808818770214 764 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM Bifunctional chorismate synthase and flavin reductase; catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids; protein abundance increases in response to DNA replication stress aromatic amino acid family biosynthetic process chorismate synthase activity|riboflavin reductase (NADPH) activity cytoplasm
YPL087W YPL087W YDC1 hom Verified 1.1387071272785 0.127412664513306 no 674 0.108022823466662 415 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Alkaline dihydroceramidase, involved in sphingolipid metabolism; preferentially hydrolyzes dihydroceramide to a free fatty acid and dihydrosphingosine; has a minor reverse activity; YDC1 has a paralog, YPC1, that arose from the whole genome duplication ceramide catabolic process|ceramide biosynthetic process dihydroceramidase activity integral to membrane|endoplasmic reticulum
YKL043W YKL043W PHD1 hom Verified 1.1386972760454 0.127414719638462 no 675 0.102441359554376 351 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Transcriptional activator that enhances pseudohyphal growth; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate; PHD1 has a paralog, SOK2, that arose from the whole genome duplication pseudohyphal growth|positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nucleus
YPL121C YPL121C MEI5 hom Verified 1.13639640925005 0.127895348954613 no 676 0.0992924748810543 347 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Sae3p; proposed to be an assembly factor for Dmc1p meiotic DNA recombinase assembly|reciprocal meiotic recombination molecular_function condensed nuclear chromosome
YLR258W YLR258W GSY2 hom Verified 1.13635175227994 0.127904689819439 no 677 0.129890144815852 473 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Glycogen synthase; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase; GSY2 has a paralog, GSY1, that arose from the whole genome duplication; relocalizes from cytoplasm to plasma membrane upon DNA replication stress glycogen biosynthetic process glycogen (starch) synthase activity cytoplasm
YGR243W YGR243W FMP43 hom Verified 1.13624588761269 0.127926835346049 no 678 0.12729269018493 525 NA FT MITOCHONDRION Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; more highly expressed in glucose-containing minimal medium than in lactate-containing medium; expression regulated by osmotic and alkaline stresses; protein abundance increases in response to DNA replication stress mitochondrial pyruvate transport pyruvate transmembrane transporter activity mitochondrion|mitochondrial membrane
YER019W YER019W ISC1 hom Verified 1.13616622829104 0.127943500807912 no 679 0.137301940694666 523 NA FT LIPID METABOLISM ENDOPLASMIC RETICULUM|MITOCHONDRION Mitochondrial membrane localized inositol phosphosphingolipid phospholipase C, hydrolyzes complex sphingolipids to produce ceramide; activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol; mediates Na+ and Li+ halotolerance response to salt stress|ceramide biosynthetic process|sphingolipid catabolic process inositol phosphosphingolipid phospholipase activity mitochondrion|endoplasmic reticulum|integral to mitochondrial outer membrane
YNR024W YNR024W MPP6 hom Verified 1.1360002102885 0.127978238146835 no 680 0.125945757578161 466 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Nuclear exosome-associated RNA binding protein; involved in surveillance of pre-rRNAs and pre-mRNAs, and the degradation of cryptic non-coding RNAs (ncRNA); copurifies with ribosomes nuclear mRNA surveillance of spliceosomal pre-mRNA splicing|nuclear mRNA surveillance of mRNA 3'-end processing|nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) poly(U) RNA binding ribosome|nucleus|nuclear exosome (RNase complex)|TRAMP complex
YOR242C YOR242C SSP2 hom Verified 1.13331194650266 0.128541638327814 no 681 0.1075165240886 412 NA FT CELL WALL ORG/BIOGENESIS Sporulation specific protein that localizes to the spore wall; required for sporulation at a point after meiosis II and during spore wall formation; SSP2 expression is induced midway in meiosis ascospore wall assembly|ascospore formation molecular_function ascospore wall
YGR057C YGR057C LST7 hom Verified 1.12862652563241 0.129527708025902 no 682 0.186925961003993 658 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface intracellular protein transport|vesicle-mediated transport|protein transport|Golgi to plasma membrane transport protein transporter activity vesicle coat
YGR078C YGR078C PAC10 hom Verified 1.12076534243457 0.131193880069977 no 683 0.168732968712096 599 NA FT PROTEIN COMPLEX ORG/BIOGENESIS Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding tubulin complex assembly tubulin binding prefoldin complex|polysome|cytoplasm
YOR268C_p YOR268C YOR268C hom Uncharacterized 1.12045140049999 0.131260725835182 no 684 0.0880099763309388 306 NA Putative protein of unknown function; sporulation is abnormal in homozygous diploid; YOR268C is not an essential gene biological_process molecular_function cellular_component
YOR209C YOR209C NPT1 hom Verified 1.12037159031024 0.131277723087366 no 685 0.189277277790335 683 NA FF|FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|GENE SILENCING|RESPONSE TO OXIDATIVE STRESS NUCLEUS Nicotinate phosphoribosyltransferase, acts in the salvage pathway of NAD+ biosynthesis; required for silencing at rDNA and telomeres and has a role in silencing at mating-type loci; localized to the nucleus chromatin silencing at rDNA|replicative cell aging|nicotinate nucleotide salvage|chromatin silencing at telomere nicotinate phosphoribosyltransferase activity nucleus
YGR160W_d YGR160W YGR160W hom Dubious 1.11958915901348 0.131444438721661 no 686 0.119257285373989 414 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGR117C_p YGR117C YGR117C hom Uncharacterized 1.1194079692704 0.131483066348281 no 687 0.098468073415393 323 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm biological_process molecular_function cytoplasm
YEL066W YEL066W HPA3 hom Verified 1.11906340259751 0.131556545727697 no 688 0.0851425970688274 321 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro D-amino acid metabolic process D-amino-acid N-acetyltransferase activity nucleus|cytoplasm
YHL011C YHL011C PRS3 hom Verified 1.1187702237964 0.131619088877531 no 689 0.151300113166887 617 NA FF|FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes fungal-type cell wall organization|5-phosphoribose 1-diphosphate biosynthetic process|regulation of cell size ribose phosphate diphosphokinase activity cytoplasm
YPL048W YPL048W CAM1 hom Verified 1.11674217864168 0.132052288947635 no 690 0.13552168954202 489 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION NUCLEUS Nuclear protein required for transcription of MXR1; binds the MXR1 promoter in the presence of other nuclear factors; binds calcium and phospholipids; has similarity to translational cofactor EF-1 gamma ribosome biogenesis|positive regulation of transcription from RNA polymerase II promoter phospholipid binding|transcription coactivator activity|calcium ion binding nucleus
YMR276W YMR276W DSK2 hom Verified 1.11489350100731 0.132448031011877 no 691 0.120379691475402 438 NA FT CELL CYCLE|PROTEOLYSIS|CYTOSKELETON ORGANIZATION NUCLEUS Nuclear-enriched ubiquitin-like polyubiquitin-binding protein; required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle; involved in proteolysis; interacts with the proteasome; protein abundance increases in response to DNA replication stress ER-associated protein catabolic process|spindle pole body duplication associated with nuclear envelope protein binding, bridging nucleus
YLR219W YLR219W MSC3 hom Verified 1.11382298098095 0.132677567991792 no 692 0.0993876638508306 383 NA FT CELL CYCLE PLASMA MEMBRANE Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; msc3 mutants are defective in directing meiotic recombination events to homologous chromatids; potential Cdc28p substrate; protein abundance increases in response to DNA replication stress reciprocal meiotic recombination molecular_function cellular_component
YJR031C YJR031C GEA1 hom Verified 1.11358577332647 0.13272846624904 no 693 0.11853501606807 423 NA FT VESICLE-MEDIATED TRANSPORT|SIGNALING|CYTOSKELETON ORGANIZATION|RESPONSE TO NUTRIENT LEVELS GOLGI APPARATUS Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA1 has a paralog, GEA2, that arose from the whole genome duplication retrograde vesicle-mediated transport, Golgi to ER|ER to Golgi vesicle-mediated transport|macroautophagy|intra-Golgi vesicle-mediated transport|actin cytoskeleton organization ARF guanyl-nucleotide exchange factor activity integral to membrane|Golgi cis cisterna|Golgi-associated vesicle|extrinsic to membrane
YHR120W YHR120W MSH1 hom Verified 1.11316505771075 0.132818773356702 no 694 0.129104237555393 499 NA FT RESPONSE TO DNA DAMAGE|MITOCHONDRION ORGANIZATION MITOCHONDRION DNA-binding protein of the mitochondria involved in repair of mitochondrial DNA, has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during meiosis DNA repair|mismatch repair|mitochondrial DNA repair|mitochondrion organization|reciprocal meiotic recombination|mitochondrial genome maintenance guanine/thymine mispair binding|dinucleotide insertion or deletion binding|DNA-dependent ATPase activity mitochondrion
YJL154C YJL154C VPS35 hom Verified 1.11310721803251 0.132831192020063 no 695 0.174945527419662 644 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p protein retention in Golgi apparatus|retrograde transport, endosome to Golgi protein transporter activity endosome|retromer complex, inner shell|retromer complex
YHR138C YHR138C YHR138C hom Verified 1.11243438248623 0.132975714199251 no 696 0.130578080119015 414 NA FT MEMBRANE ORGANIZATION Protein of unknown function; similar to Pbi2p; double null mutant lacking Pbi2p and Yhr138cp exhibits highly fragmented vacuoles; protein abundance increases in response to DNA replication stress vacuole fusion, non-autophagic endopeptidase inhibitor activity cellular_component
YLR349W_d YLR349W YLR349W hom Dubious 1.11221166830581 0.133023576083805 no 697 0.122247116442506 410 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF DIC1/YLR348C Unknown Unknown Unknown
YBL104C YBL104C SEA4 hom Verified 1.10998448495274 0.133502856115093 no 698 0.195431492620404 681 NA Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; has an N-terminal beta-propeller fold and a C-terminal RING motif; promoter contains multiple GCN4 binding sites biological_process molecular_function Seh1-associated complex|extrinsic to fungal-type vacuolar membrane|cytoplasm
YNR057C YNR057C BIO4 hom Verified 1.10942236134867 0.133624010105924 no 699 0.151035530356662 559 NA FT KETONE METABOLISM|COFACTOR METABOLISM Dethiobiotin synthetase, catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; expression appears to be repressed at low iron levels biotin biosynthetic process dethiobiotin synthase activity cytoplasm
YDR537C_d YDR537C YDR537C hom Dubious 1.10934650742686 0.133640364620245 no 700 0.129611745040951 463 NA Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W Unknown Unknown Unknown
YPR043W YPR043W RPL43A hom Verified 1.10721047601715 0.134101469631629 no 701 0.0975889488916166 387 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L43A; null mutation confers a dominant lethal phenotype; homologous to mammalian ribosomal protein L37A, no bacterial homolog; RPL43A has a paralog, RPL43B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YOL073C YOL073C YOL073C hom Verified 1.1065145553505 0.134251933778069 no 702 0.130915711197405 472 NA Subunit of the DSC ubiquitin ligase complex; ortholog of fission yeast dsc2 biological_process molecular_function integral to membrane
YOR006C YOR006C TSR3 hom Verified 1.10579143955536 0.134408400541529 no 703 0.165649074380962 573 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Protein required for 20S pre-rRNA processing; involved in processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress maturation of SSU-rRNA molecular_function nucleus|cytoplasm
YJL208C YJL208C NUC1 hom Verified 1.10542578324366 0.134487568378729 no 704 0.133942019481232 468 NA FT NUCLEUS|MITOCHONDRION Major mitochondrial nuclease, has RNAse and DNA endo- and exonucleolytic activities; has roles in mitochondrial recombination, apoptosis and maintenance of polyploidy DNA catabolic process|RNA catabolic process|apoptotic process|DNA recombination ribonuclease activity|endodeoxyribonuclease activity|exodeoxyribonuclease activity mitochondrion|mitochondrial inner membrane|nucleus
YJL158C YJL158C CIS3 hom Verified 1.10293029812688 0.135028717767791 no 705 0.117992723347262 420 NA FT CELL WALL ORG/BIOGENESIS ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family fungal-type cell wall organization structural constituent of cell wall extracellular region|fungal-type cell wall|endoplasmic reticulum|plasma membrane|cellular bud tip
YGL035C YGL035C MIG1 hom Verified 1.10214301604447 0.135199750429757 no 706 0.153829785004429 549 NA FT TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS ENDOMEMBRANE SYSTEM|NUCLEUS Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion negative regulation of transcription from RNA polymerase II promoter by glucose|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding nucleus|nuclear envelope lumen|cytoplasm
YER061C YER061C CEM1 hom Verified 1.09947193776886 0.135781133865577 no 707 0.157757579327516 580 NA FT KETONE METABOLISM|LIPID METABOLISM MITOCHONDRION Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration fatty acid biosynthetic process fatty acid synthase activity mitochondrion
YER097W_d YER097W YER097W hom Dubious 1.097674411236 0.136173343639903 no 708 0.173146418367321 589 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YJL028W YJL028W YJL028W hom Verified 1.09737031699614 0.136239771825655 no 709 0.0999225635634378 352 NA Protein of unknown function; may interact with ribosomes, based on co-purification experiments biological_process molecular_function ribosome
YDR516C YDR516C EMI2 hom Verified 1.0926602668025 0.137271495600135 no 710 0.134396865512098 478 NA FT TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression regulated by glucose-repression transcription factors Mig1/2p; EMI2 has a paralog, GLK1, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress ascospore formation|positive regulation of transcription from RNA polymerase II promoter molecular_function cytoplasm
YIL052C YIL052C RPL34B hom Verified 1.08807352276416 0.138281325663176 no 711 0.177661982329079 653 NA FF|FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YOR150W YOR150W MRPL23 hom Verified 1.08543124890996 0.13886534919675 no 712 0.168844613397895 588 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YIL007C YIL007C NAS2 hom Verified 1.08498502887295 0.138964143041507 no 713 0.113587381888872 447 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|PROTEOLYSIS NUCLEUS Proteasome-interacting protein; involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); similar to mammalian proteasomal modulator subunit; non-essential gene; interacts with Rpn4p; protein abundance increases in response to DNA replication stress proteasome regulatory particle assembly|ubiquitin-dependent protein catabolic process molecular_function cytosol|nucleus|cytoplasm
YBR027C_d YBR027C YBR027C hom Dubious 1.08408939349464 0.139162582563335 no 714 0.114203111942748 445 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOR021C YOR021C SFM1 hom Verified 1.08207897705856 0.139608718181082 no 715 0.126728637060584 469 NA SPOUT methyltransferase; catalyzes omega-monomethylation of Rps3p on Arg-146; not an essential gene; predicted to be involved in rRNA processing and ribosome biogenesis and in biopolymer catabolism peptidyl-arginine methylation protein-arginine omega-N monomethyltransferase activity cellular_component
YPL091W YPL091W GLR1 hom Verified 1.08184490847482 0.139660723958142 no 716 0.154499000773922 599 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS NUCLEUS|MITOCHONDRION Cytosolic and mitochondrial glutathione oxidoreductase; converts oxidized glutathione to reduced glutathione; mitochondrial but not cytosolic form has a role in resistance to hyperoxia; protein abundance increases in response to DNA replication stress cellular response to oxidative stress|protein glutathionylation glutathione-disulfide reductase activity mitochondrion|nucleus|cytoplasm
YOR001W YOR001W RRP6 hom Verified 1.07903972377412 0.140285009826088 no 717 0.0862210734654838 345 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|RNA LOCALIZATION NUCLEUS Nuclear exosome exonuclease component; has 3'-5' exonuclease activity; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10); mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent snRNA catabolic process|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|histone mRNA catabolic process|nuclear polyadenylation-dependent antisense transcript catabolic process|U1 snRNA 3'-end processing|polyadenylation-dependent snoRNA 3'-end processing|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|U5 snRNA 3'-end processing|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear retention of pre-mRNA at the site of transcription|nuclear polyadenylation-dependent mRNA catabolic process|U4 snRNA 3'-end processing|nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription 3'-5'-exoribonuclease activity nucleolus|nucleus|nuclear exosome (RNase complex)
YEL057C_p YEL057C YEL057C hom Uncharacterized 1.07879671196019 0.140339180477012 no 718 0.111879017645372 407 NA Protein of unknown function involved in telomere maintenance; target of UME6 regulation biological_process molecular_function cellular_component
YNL116W YNL116W DMA2 hom Verified 1.0787659176558 0.140346045961805 no 719 0.175568391831053 600 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION Ubiquitin-protein ligase (E3); controls septin dynamics and the spindle position checkpoint (SPOC) along with functionally redundant ligase Dma1p by regulating the recruitment of Elm1p to the bud neck; regulates levels of the translation initiation factor eIF2 subunit Gcd11p, as well as abundance, localization, and ubiquitination of Cdk inhibitory kinase Swe1p; ortholog of human RNF8 protein, with sequence similarity to human Chfr; contains FHA and RING finger domains establishment of mitotic spindle orientation|protein autoubiquitination|septin ring assembly|mitotic cell cycle spindle assembly checkpoint ubiquitin-protein ligase activity cytoplasm
YNL143C_p YNL143C YNL143C hom Uncharacterized 1.07787181063717 0.140545483513148 no 720 0.15954737276927 492 NA Protein of unknown function; expressed at both mRNA and protein levels biological_process molecular_function cellular_component
YLR370C YLR370C ARC18 hom Verified 1.0775957099191 0.14060710879204 no 721 0.218933606481526 791 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION MITOCHONDRION|CYTOSKELETON Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches mitochondrion inheritance|actin filament organization|establishment of mitochondrion localization molecular_function mitochondrion|Arp2/3 protein complex
YOL032W YOL032W OPI10 hom Verified 1.07731975268183 0.140668720369718 no 722 0.116930473046369 425 NA FT LIPID METABOLISM|CARBOHYDRATE METABOLISM NUCLEUS Protein with a possible role in phospholipid biosynthesis; null mutant displays an inositol-excreting phenotype that is suppressed by exogenous choline; protein abundance increases in response to DNA replication stress inositol metabolic process molecular_function nucleus|cytoplasm
YNL023C YNL023C FAP1 hom Verified 1.07493690664495 0.14120148848796 no 723 0.112054215859894 400 NA FT NUCLEUS Protein that binds to Fpr1p, conferring rapamycin resistance by competing with rapamycin for Fpr1p binding; accumulates in the nucleus upon treatment of cells with rapamycin; has similarity to D. melanogaster shuttle craft and human NFX1 biological_process sequence-specific DNA binding transcription factor activity cytoplasm
YGL129C YGL129C RSM23 hom Verified 1.07357148288174 0.141507392250186 no 724 0.153904952647618 571 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit, has similarity to mammalian apoptosis mediator proteins; null mutation prevents induction of apoptosis by overproduction of metacaspase Mca1p mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YGL228W YGL228W SHE10 hom Verified 1.0723979590575 0.141770662135709 no 725 0.137995524819887 520 NA FT MITOCHONDRION Putative glycosylphosphatidylinositol (GPI)-anchored protein of unknown function; overexpression causes growth arrest biological_process molecular_function cellular_component
YNR032C-A YNR032C-A HUB1 hom Verified 1.07210268500939 0.14183695650677 no 726 0.117804173082883 478 NA FT RNA PROCESSING Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear cellular protein modification process|cell morphogenesis involved in conjugation with cellular fusion|mRNA splicing, via spliceosome protein tag mating projection
YDR428C YDR428C BNA7 hom Verified 1.06695901937466 0.142995170881878 no 727 0.119807780111597 432 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM Formylkynurenine formamidase, involved in the de novo biosynthesis of NAD from tryptophan via kynurenine NAD biosynthetic process arylformamidase activity cellular_component
YLR146C YLR146C SPE4 hom Verified 1.06649428932034 0.143100129409716 no 728 0.129884367856651 497 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM Spermine synthase, required for the biosynthesis of spermine and also involved in biosynthesis of pantothenic acid pantothenate biosynthetic process|spermine biosynthetic process spermine synthase activity cytoplasm
YPR017C YPR017C DSS4 hom Verified 1.06610955180562 0.143187061122208 no 729 0.152222260111648 584 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING Guanine nucleotide dissociation stimulator for Sec4p, functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol post-Golgi vesicle-mediated transport zinc ion binding|guanyl-nucleotide exchange factor activity cytosol|membrane
YHR111W YHR111W UBA4 hom Verified 1.06318619294336 0.143848761265602 no 730 0.154734255576094 561 NA FT RNA PROCESSING|CELL DIVISION|RESPONSE TO OXIDATIVE STRESS Protein that activates Urm1p before its conjugation to proteins (urmylation); also acts in thiolation of the wobble base of cytoplasmic tRNAs by adenylating and then thiolating Urm1p; receives sulfur from Tum1p cellular response to oxidative stress|tRNA wobble position uridine thiolation|cell budding|protein urmylation|tRNA thio-modification|Unknown|invasive growth in response to glucose limitation URM1 activating enzyme activity|sulfurtransferase activity|thiosulfate sulfurtransferase activity|protein adenylyltransferase activity cytoplasm
YKR088C YKR088C TVP38 hom Verified 1.06191819945219 0.144136411101393 no 731 0.144572716543588 525 NA FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|CYTOSKELETON ORGANIZATION ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; required for asymmetric localization of Kar9p during mitosis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern vesicle-mediated transport|mitotic spindle elongation molecular_function integral to membrane|integral to Golgi membrane|cytoplasm
YIL087C YIL087C AIM19 hom Verified 1.06016328941847 0.1445351594944 no 732 0.131385122941918 444 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth biological_process molecular_function mitochondrion
YDR387C_p YDR387C YDR387C hom Uncharacterized 1.05850240757578 0.144913226865334 no 733 0.115598557374953 413 NA Putative transporter, member of the sugar porter family; YDR387C is not an essential gene transport|transmembrane transport substrate-specific transmembrane transporter activity integral to membrane|membrane
YNR032W YNR032W PPG1 hom Verified 1.05768070596937 0.14510051718393 no 734 0.139960882651219 441 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Putative serine/threonine protein phosphatase of the type 2A-like phosphatase family, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases glycogen metabolic process|protein dephosphorylation protein serine/threonine phosphatase activity nucleus|cytoplasm
YDR536W YDR536W STL1 hom Verified 1.05710679763953 0.1452314246064 no 735 0.146608268325528 548 NA FT PLASMA MEMBRANE Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock transport|glycerol transport|transmembrane transport solute:hydrogen symporter activity|transporter activity integral to membrane|plasma membrane|membrane
YDL100C YDL100C GET3 hom Verified 1.05063018553232 0.146714235905047 no 736 0.216641998097373 725 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|NUCLEOTIDE METABOLISM ENDOPLASMIC RETICULUM|GOLGI APPARATUS Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity; protein abundance increases in response to DNA replication stress retrograde vesicle-mediated transport, Golgi to ER|pheromone-dependent signal transduction involved in conjugation with cellular fusion|response to heat|protein insertion into ER membrane|response to metal ion|posttranslational protein targeting to membrane ATPase activity|guanyl-nucleotide exchange factor activity endoplasmic reticulum|GET complex
YGL086W YGL086W MAD1 hom Verified 1.05046633869175 0.146751879685015 no 737 0.137319673232812 479 NA FT CELL CYCLE|CELL DIVISION ENDOMEMBRANE SYSTEM|NUCLEUS|CHROMOSOME NUCLEAR PORE|KINETOCHORE Coiled-coil protein involved in the spindle-assembly checkpoint; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon spindle assembly checkpoint arrest; phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of the activity of the anaphase promoting complex; forms a complex with Mad2p nucleocytoplasmic transport|mitotic cell cycle spindle assembly checkpoint|mitotic cell cycle G2/M transition decatenation checkpoint molecular_function nucleus|nuclear pore|kinetochore
YGR014W YGR014W MSB2 hom Verified 1.04772259131826 0.147383217964595 no 738 0.183244847818731 620 NA FT SIGNALING SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Mucin family member involved in signaling; functions in the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; is processed into secreted and cell-associated forms by the aspartyl protease, Yps1p; also functions as an osmosensor in parallel to the Sho1p-mediated pathway; potential Cdc28p substrate signal transduction involved in filamentous growth|osmosensory signaling pathway via Sho1 osmosensor|establishment of cell polarity|hyperosmotic response|response to osmotic stress osmosensor activity site of polarized growth|integral to plasma membrane
YOR189W YOR189W IES4 hom Verified 1.04770480564035 0.14738731639057 no 739 0.15077674159462 531 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Component of the INO80 chromatiin remodeling complex and target of the Mec1p/Tel1p DNA damage signaling pathway; proposed to link chromatin remodeling to replication checkpoint responses response to DNA damage stimulus molecular_function nucleus|Ino80 complex
YLR415C_p YLR415C YLR415C hom Uncharacterized 1.04575734371578 0.147836539980623 no 740 0.149976376399628 506 NA FT MITOCHONDRION Putative protein of unknown function; YLR415C is not an essential gene biological_process molecular_function cellular_component
YEL050C YEL050C RML2 hom Verified 1.0414678269488 0.148829238770765 no 741 0.193691105709866 677 NA FF|FT KETONE METABOLISM|LIPID METABOLISM|TRANSLATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor cytoplasmic translation|fatty acid metabolic process structural constituent of ribosome mitochondrial large ribosomal subunit
YDL070W YDL070W BDF2 hom Verified 1.03986964466767 0.149200233536841 no 742 0.140130463520963 493 NA FT CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS Protein involved in transcription initiation; acts at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf1p; protein abundance increases in response to DNA replication stress negative regulation of heterochromatin assembly histone acetyl-lysine binding|core promoter binding|histone binding|TFIID-class transcription factor binding nucleus
YBR186W YBR186W PCH2 hom Verified 1.03884033015057 0.149439500616879 no 743 0.11041632164515 391 NA FT CELL CYCLE NUCLEUS|CHROMOSOME Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA; required for meiotic double-stranded break formation meiotic recombination checkpoint|meiotic DNA double-strand break formation|reciprocal meiotic recombination ATPase activity nucleolus
YGR017W_p YGR017W YGR017W hom Uncharacterized 1.0380241863187 0.149629397517293 no 744 0.111813927502558 381 NA FT OXIDATION-REDUCTION PROCESS NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm biological_process molecular_function nucleus|cytoplasm
YOR164C YOR164C GET4 hom Verified 1.03758064357752 0.149732666669765 no 745 0.166771917411461 572 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Mdy2p; highly conserved across species and homologous to human gene C7orf20 protein insertion into ER membrane|posttranslational protein targeting to membrane molecular_function TRC complex|cytoplasm
YOR305W YOR305W RRG7 hom Verified 1.03726986460946 0.149805053026161 no 746 0.138129061282566 520 NA FT MITOCHONDRION Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YOR305W is not an essential gene biological_process molecular_function mitochondrion
YOR147W YOR147W MDM32 hom Verified 1.03627762725548 0.150036320264209 no 747 0.148329995620708 538 NA FT ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS MITOCHONDRION Mitochondrial inner membrane protein with similarity to Mdm31p, required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34 mitochondrion inheritance|cellular ion homeostasis|mitochondrion organization molecular_function mitochondrion|mitochondrial inner membrane
YER019C-A YER019C-A SBH2 hom Verified 1.03517180656004 0.150294341444315 no 748 0.14701219703238 499 NA FT PROTEIN LOCALIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p SRP-dependent cotranslational protein targeting to membrane ARF guanyl-nucleotide exchange factor activity Ssh1 translocon complex
YER044C-A YER044C-A MEI4 hom Verified 1.03446041822581 0.150460485918475 no 749 0.13800523054668 497 NA FT CELL CYCLE NUCLEUS|CHROMOSOME Meiosis-specific protein involved in double-strand break formation during meiotic recombination; required for chromosome synapsis and production of viable spores meiotic DNA double-strand break formation molecular_function condensed nuclear chromosome
YOR274W YOR274W MOD5 hom Verified 1.03058854593786 0.151366904825897 no 750 0.159079942308463 579 NA FT RNA PROCESSING NUCLEUS|MITOCHONDRION Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase; required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms; converts to a prion form, and prion conversion contributes to azole antifungal resistance by upregulating ergosterol biosynthesis tRNA modification tRNA dimethylallyltransferase activity cytosol|mitochondrion|nucleolus|nucleus
YDR320C YDR320C SWA2 hom Verified 1.03049749285782 0.151388264283979 no 751 0.213835576709489 698 NA FF|FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|NUCLEOTIDE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles positive regulation of ATPase activity|endoplasmic reticulum inheritance|clathrin coat disassembly ubiquitin binding|clathrin binding endoplasmic reticulum membrane
YMR306C-A_d YMR306C-A YMR306C-A hom Dubious 1.03045470227145 0.151398302898477 no 752 0.133715347196568 491 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPR191W YPR191W QCR2 hom Verified 1.03043082345767 0.151403905028779 no 753 0.131511064710506 499 NA FT OXIDATION-REDUCTION PROCESS|PROTEOLYSIS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Subunit 2 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; phosphorylated; transcription is regulated by Hap1p, Hap2p/Hap3p, and heme mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration ubiquinol-cytochrome-c reductase activity mitochondrion|integral to membrane|mitochondrial crista|mitochondrial respiratory chain complex III
YML041C YML041C VPS71 hom Verified 1.02916976418632 0.151699953882343 no 754 0.193534862710117 699 NA FF|FT PROTEIN LOCALIZATION|CHROMATIN ORGANIZATION|VACUOLAR TRANSPORT NUCLEUS|CHROMOSOME Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting chromatin remodeling|protein targeting to vacuole|histone exchange nucleosome binding Swr1 complex|nucleus
YGR165W YGR165W MRPS35 hom Verified 1.02893838874457 0.151754313795999 no 755 0.194617557944276 678 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YFL056C YFL056C AAD6 hom Verified 1.02890493945422 0.151762173525119 no 756 0.146478274077395 538 NA FT OXIDATION-REDUCTION PROCESS Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin cellular aldehyde metabolic process aryl-alcohol dehydrogenase (NAD+) activity cellular_component
YIR039C YIR039C YPS6 hom Verified 1.02471224773088 0.152749491139462 no 757 0.174692059086095 607 NA FT CELL WALL ORG/BIOGENESIS|PROTEOLYSIS PLASMA MEMBRANE Putative GPI-anchored aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance fungal-type cell wall organization aspartic-type endopeptidase activity fungal-type cell wall
YMR225C YMR225C MRPL44 hom Verified 1.02392284861318 0.152935858595302 no 758 0.149578055258706 546 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YFR025C YFR025C HIS2 hom Verified 1.02188450885312 0.153417782592382 no 759 0.130535351145143 419 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Histidinolphosphatase, catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control histidine biosynthetic process histidinol-phosphatase activity intracellular
YKL053W_d YKL053W YKL053W hom Dubious 1.02046264089602 0.153754549318825 no 760 0.139280738482804 515 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF ASK1 Unknown Unknown Unknown
YDL032W_d YDL032W YDL032W hom Dubious 1.01972513722775 0.153929418255247 no 761 0.185757940219518 629 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene SLM3/YDL033C; YDL032W is not an essential gene Unknown Unknown Unknown
YDR146C YDR146C SWI5 hom Verified 1.01909462688074 0.154079022401342 no 762 0.133545668229286 482 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE NUCLEUS Transcription factor that recruits Mediator and Swi/Snf complexes; activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; required for expression of the HO gene controlling mating type switching; localization to nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase; SWI5 has a paralog, ACE2, that arose from the whole genome duplication positive regulation of mating type switching|regulation of transcription involved in G1 phase of mitotic cell cycle|positive regulation of transcription on exit from mitosis, from RNA polymerase II promoter RNA polymerase II distal enhancer sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity|mediator complex binding nucleus|cytoplasm
YDL021W YDL021W GPM2 hom Verified 1.01890301628564 0.154124505797042 no 763 0.160569070649038 542 NA FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event biological_process phosphoglycerate mutase activity|molecular_function cytosol|cytoplasm
YPL066W YPL066W RGL1 hom Verified 1.01770064274636 0.154410120866315 no 764 0.194048739072543 723 NA FF|FT SITE OF POLARIZED GROWTH Regulator of Rho1p signaling, cofactor of Tus1p; required for the localization of Tus1p during all phases of cytokinesis; green fluorescent protein (GFP)-fusion protein localizes to the bud neck and cytoplasm; null mutant is viable and exhibits growth defect on a non-fermentable (respiratory) carbon source protein localization to bud neck molecular_function cellular bud neck|cytoplasm
YDR375C YDR375C BCS1 hom Verified 1.01677485801784 0.154630272572144 no 765 0.173449562384044 595 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases protein insertion into mitochondrial membrane from inner side|chaperone-mediated protein complex assembly|mitochondrial respiratory chain complex III assembly protein transmembrane transporter activity|ATPase activity mitochondrion|mitochondrial inner membrane
YNL051W YNL051W COG5 hom Verified 1.01601463747828 0.154811208124002 no 766 0.242999598745775 818 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments intra-Golgi vesicle-mediated transport|CVT pathway molecular_function Golgi transport complex
YDL022W YDL022W GPD1 hom Verified 1.01164999786663 0.155852715566271 no 767 0.154592756046285 531 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM NUCLEUS NAD-dependent glycerol-3-phosphate dehydrogenase; key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p; protein abundance increases in response to DNA replication stress; constitutively inactivated via phosphorylation by the protein kinases YPK1 and YPK2, dephosphorylation increases catalytic activity NADH oxidation|intracellular accumulation of glycerol glycerol-3-phosphate dehydrogenase [NAD+] activity cytosol|peroxisome|nucleus
YNL332W YNL332W THI12 hom Verified 1.01118175191131 0.155964723996061 no 768 0.138938930462618 517 NA Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13 thiamine biosynthetic process molecular_function cellular_component
YDL052C YDL052C SLC1 hom Verified 1.01079930765006 0.156056247284805 no 769 0.181528947475993 630 NA FT LIPID METABOLISM 1-acyl-sn-glycerol-3-phosphate acyltransferase, catalyzes the acylation of lysophosphatidic acid to form phosphatidic acid, a key intermediate in lipid metabolism; enzymatic activity detected in lipid particles and microsomes glycerophospholipid biosynthetic process 1-acylglycerol-3-phosphate O-acyltransferase activity lipid particle
YOR288C YOR288C MPD1 hom Verified 1.0107532502678 0.156067271730944 no 770 0.13544422071621 476 NA FT ENDOPLASMIC RETICULUM Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation protein folding protein disulfide oxidoreductase activity|protein disulfide isomerase activity fungal-type vacuole
YFR055W_p YFR055W IRC7 hom Uncharacterized 1.0106940847878 0.156081434527485 no 771 0.161273392141704 546 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Beta-lyase involved in the production of thiols; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner and by copper levels in a Mac1-dependent manner sulfur compound metabolic process|L-cysteine catabolic process to pyruvate cysteine-S-conjugate beta-lyase activity cellular_component
YER167W YER167W BCK2 hom Verified 1.00839187259006 0.156633186556685 no 772 0.184471191055041 655 NA FT CELL CYCLE NUCLEUS Protein rich in serine and threonine residues involved in protein kinase C signaling pathway, which controls cell integrity; overproduction suppresses pkc1 mutations regulation of cell cycle|positive regulation of gene expression|G1/S transition of mitotic cell cycle molecular_function nucleus|cytoplasm
YLR164W YLR164W SHH4 hom Verified 1.00752032273223 0.156842398284815 no 773 0.126719843279785 448 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Mitochondrial inner membrane protein of unknown function; similar to Tim18p and Sdh4p; a fraction copurifies with Sdh3p, but Shh4p is neither a stoichiometric subunit of succinate dehydrogenase nor of the TIM22 translocase; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner biological_process molecular_function mitochondrion|mitochondrial inner membrane
YBR046C YBR046C ZTA1 hom Verified 1.00500478275141 0.157447273433652 no 774 0.161872431024029 554 NA FT OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS NUCLEUS NADPH-dependent quinone reductase, GFP-tagged protein localizes to the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin cellular response to oxidative stress NADPH:quinone reductase activity|AU-rich element binding|2-alkenal reductase [NAD(P)] activity nucleus|cytoplasm
YMR158W-B_d YMR158W-B YMR158W-B hom Dubious 1.0046922834576 0.157522522491931 no 775 0.139054605369228 521 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene ATG16/YMR159C Unknown Unknown Unknown
YOR061W YOR061W CKA2 hom Verified 1.00257740559395 0.158032400939752 no 776 0.180130845283977 684 NA FF|FT RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION NUCLEUS Alpha' catalytic subunit of casein kinase 2 (CK2); CK2 is a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; protein abundance increases in response to DNA replication stress; regulates Fkh1p-mediated donor preference during mating-type switching regulation of transcription from RNA polymerase I promoter|chronological cell aging|protein phosphorylation|regulation of transcription from RNA polymerase III promoter|response to DNA damage stimulus protein serine/threonine kinase activity protein kinase CK2 complex|UTP-C complex
YCL009C YCL009C ILV6 hom Verified 1.00091875498873 0.158433044246206 no 777 0.149378077821773 499 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Regulatory subunit of acetolactate synthase, which catalyzes the first step of branched-chain amino acid biosynthesis; enhances activity of the Ilv2p catalytic subunit, localizes to mitochondria branched-chain amino acid biosynthetic process enzyme regulator activity|acetolactate synthase activity mitochondrial nucleoid|acetolactate synthase complex|mitochondrion
YDR369C YDR369C XRS2 hom Verified 1.00028332798084 0.158586706566726 no 778 0.172602689540622 624 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling double-strand break repair via nonhomologous end joining|meiotic DNA double-strand break formation|base-excision repair|telomere maintenance|sporulation resulting in formation of a cellular spore|double-strand break repair via break-induced replication single-stranded telomeric DNA binding|protein binding, bridging|DNA binding|double-stranded telomeric DNA binding|telomeric DNA binding|G-quadruplex DNA binding nucleus|Mre11 complex
YPL119C-A_p YPL119C-A YPL119C-A hom Uncharacterized 0.999926902977739 0.15867294191734 no 779 0.154783329347096 527 NA Putative protein of unknown function; identified by expression profiling and mass spectrometry biological_process molecular_function cellular_component
YCR061W_p YCR061W YCR061W hom Uncharacterized 0.99949773339214 0.15877681826765 no 780 0.163960902928595 604 NA Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; induced by treatment with 8-methoxypsoralen and UVA irradiation regulation of cell size molecular_function integral to membrane|cytoplasm
YNL226W_d YNL226W YNL226W hom Dubious 0.999421142301201 0.158795361087546 no 781 0.160312394360548 568 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene JJJ1/YNL227C Unknown Unknown Unknown
YHR202W_p YHR202W YHR202W hom Uncharacterized 0.999407162329295 0.15879874581325 no 782 0.159441625321226 603 NA FT NUCLEOTIDE METABOLISM Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization biological_process molecular_function cytosol|fungal-type vacuole
YOR081C YOR081C TGL5 hom Verified 0.998754982445204 0.158956699266806 no 783 0.138397060305102 464 NA FT LIPID METABOLISM Bifunctional enzyme with triacylglycerol lipase and lysophosphatidic acid acyltransferase activity; involved in triacylglycerol mobilization; localizes to lipid particles; potential Cdc28p substrate triglyceride mobilization lysophosphatidic acid acyltransferase activity|triglyceride lipase activity lipid particle
YCR077C YCR077C PAT1 hom Verified 0.997462079600548 0.159270135639999 no 784 0.17653013973872 650 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|TRANSLATION|CELL DIVISION|CHROMOSOME SEGREGATION NUCLEUS RIBOSOME Deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; associated with topoisomerase II; functionally linked to Pab1p; forms cytoplasmic foci upon DNA replication stress deadenylation-dependent decapping of nuclear-transcribed mRNA|chromosome segregation|regulation of translational initiation|formation of translation preinitiation complex|negative regulation of translational initiation|cytoplasmic mRNA processing body assembly molecular_function cytosolic small ribosomal subunit|cytoplasmic mRNA processing body
YDR231C YDR231C COX20 hom Verified 0.996978104158014 0.159387569076804 no 785 0.160974221249681 547 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase mitochondrial respiratory chain complex IV assembly|protein processing|aerobic respiration unfolded protein binding mitochondrion|mitochondrial inner membrane
YMR097C YMR097C MTG1 hom Verified 0.995908920803641 0.159647200246429 no 786 0.179114267891018 643 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Putative GTPase peripheral to the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals mitochondrial translation GTPase activity mitochondrion|mitochondrial inner membrane
YGR189C YGR189C CRH1 hom Verified 0.994798001915187 0.159917259120969 no 787 0.139980617969053 476 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress fungal-type cell wall organization|cell wall chitin metabolic process transferase activity, transferring glycosyl groups incipient cellular bud site|fungal-type cell wall
YLR225C_p YLR225C YLR225C hom Uncharacterized 0.994797013581124 0.159917499513033 no 788 0.166894007430559 585 NA FT RESPONSE TO OXIDATIVE STRESS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR225C is not an essential gene biological_process molecular_function cytoplasm
YDR294C YDR294C DPL1 hom Verified 0.994723199472811 0.159935453954412 no 789 0.134193298927666 454 NA FT KETONE METABOLISM|LIPID METABOLISM|SIGNALING|RESPONSE TO NUTRIENT LEVELS ENDOPLASMIC RETICULUM Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate calcium-mediated signaling|sphingolipid metabolic process|cellular response to starvation sphinganine-1-phosphate aldolase activity endoplasmic reticulum|cortical endoplasmic reticulum|perinuclear endoplasmic reticulum
YOL087C YOL087C DUF1 hom Verified 0.994112918917391 0.160083948259324 no 790 0.228027410938508 767 NA Ubiquitin-binding protein of unknown function; contains one WD40 repeat in a beta-propeller fold; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; homolog of human WDR48/UAF1, which is involved in regulating the Fanconi anemia pathway; deletion mutant is sensitive to various chemicals including phenanthroline, sanguinarine, and nordihydroguaiaretic acid biological_process ubiquitin binding cytoplasm
YDR253C YDR253C MET32 hom Verified 0.993832825293097 0.160152131196893 no 791 0.181981952101518 639 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CELL CYCLE|AMINO ACID METABOLISM NUCLEUS Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; MET32 has a paralog, MET31, that arose from the whole genome duplication regulation of mitotic cell cycle|regulation of sulfur amino acid metabolic process|regulation of transcription from RNA polymerase II promoter core promoter proximal region sequence-specific DNA binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity nucleus|cytoplasm
YNR056C YNR056C BIO5 hom Verified 0.992348348184477 0.160513813019631 no 792 0.155516540294772 560 NA FT KETONE METABOLISM|COFACTOR METABOLISM PLASMA MEMBRANE Putative transmembrane protein involved in the biotin biosynthesis pathway; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis biotin biosynthetic process|vitamin transport transmembrane transporter activity integral to membrane|plasma membrane
YKR085C YKR085C MRPL20 hom Verified 0.992159953552382 0.160559752100346 no 793 0.172041916507144 611 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YKL213C YKL213C DOA1 hom Verified 0.991672348466458 0.160678692017696 no 794 0.149858017793138 539 NA FT RESPONSE TO DNA DAMAGE|PROTEOLYSIS NUCLEUS WD repeat protein required for ubiquitin-mediated protein degradation; forms a complex with Cdc48p; plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon DNA replication stress double-strand break repair via nonhomologous end joining|ubiquitin-dependent protein catabolic process ubiquitin binding nucleus|cytoplasm
YDL174C YDL174C DLD1 hom Verified 0.991381999632333 0.160749543187337 no 795 0.132218517843863 471 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane cellular carbohydrate metabolic process|aerobic respiration D-lactate dehydrogenase (cytochrome) activity mitochondrion|mitochondrial inner membrane
YML129C YML129C COX14 hom Verified 0.991294511375004 0.160770896145395 no 796 0.168259443040308 583 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes mitochondrial respiratory chain complex IV assembly|negative regulation of mitochondrial translation molecular_function mitochondrial envelope|mitochondrion|integral to membrane|mitochondrial inner membrane|mitochondrial matrix|extrinsic to membrane
YJL062W-A YJL062W-A COA3 hom Verified 0.987553686145658 0.161685638957913 no 797 0.150070697573994 540 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly mitochondrial respiratory chain complex IV assembly|negative regulation of mitochondrial translation molecular_function mitochondrion|mitochondrial inner membrane|integral to mitochondrial inner membrane
YDR488C YDR488C PAC11 hom Verified 0.986889268737885 0.161848462804672 no 798 0.126354566520325 429 NA FT CYTOSKELETON Dynein intermediate chain, acts in the cytoplasmic dynein pathway, forms cortical cytoplasmic microtubule capture site with Num1p; null mutant is defective in nuclear migration, essential in the absence of CIN8 nuclear migration along microtubule|microtubule-based process plus-end-directed microtubule motor activity|microtubule motor activity cytoplasmic dynein complex|cytoplasmic microtubule
YMR013W-A_d YMR013W-A YMR013W-A hom Dubious 0.986423852420633 0.161962582538419 no 799 0.150304275624103 512 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the characterized snoRNA gene snR73 Unknown Unknown Unknown
YHR205W YHR205W SCH9 hom Verified 0.985987562148779 0.162069608175109 no 800 0.143545428177642 501 NA FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|PROTEIN PHOSPHORYLATION|RESPONSE TO OXIDATIVE STRESS NUCLEUS|CHROMOSOME AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan protein phosphorylation|age-dependent response to oxidative stress involved in chronological cell aging|replicative cell aging|regulation of protein localization|positive regulation of transcription from RNA polymerase III promoter|positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase I promoter|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|regulation of cell size|regulation of response to osmotic stress protein serine/threonine kinase activity chromatin|fungal-type vacuole membrane|nucleus|cytoplasm
YBR171W YBR171W SEC66 hom Verified 0.985407799073815 0.162211900139821 no 801 0.277671734647719 969 NA FF|FT PROTEIN LOCALIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER posttranslational protein targeting to membrane, translocation|filamentous growth protein transporter activity integral to membrane|Sec62/Sec63 complex|endoplasmic reticulum membrane
YBL099W YBL099W ATP1 hom Verified 0.984907018073602 0.162334872889911 no 802 0.17552260201606 661 NA FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS MITOCHONDRION Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated ATP synthesis coupled proton transport hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism mitochondrial nucleoid|proton-transporting ATP synthase complex, catalytic core F(1)|mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase, catalytic core
YNR063W_p YNR063W YNR063W hom Uncharacterized 0.984710847378188 0.162383061482509 no 803 0.144993877671588 515 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Putative zinc-cluster protein of unknown function biological_process sequence-specific DNA binding cellular_component
YOR303W YOR303W CPA1 hom Verified 0.983571511885117 0.162663119000926 no 804 0.143662900082745 462 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Small subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader arginine biosynthetic process carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity carbamoyl-phosphate synthase complex
YOR228C YOR228C YOR228C hom Verified 0.98263569719746 0.162893384408715 no 805 0.167065210179739 583 NA FT MITOCHONDRION Protein of unknown function, localized to the mitochondrial outer membrane biological_process molecular_function mitochondrial outer membrane|mitochondrion|integral to membrane
YBL024W YBL024W NCL1 hom Verified 0.982597443190276 0.162902801649379 no 806 0.200728274475115 635 NA FT RNA PROCESSING NUCLEUS S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase, methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; increases proportion of tRNALeu(CAA) with m5C at wobble position in response to hydrogen peroxide, causing selective translation of mRNA from genes enriched in TTG codon; loss of NCL1 confers hypersensitivity to oxidative stress; similar to Nop2p and human proliferation associated nucleolar protein p120 tRNA methylation tRNA (cytosine-5-)-methyltransferase activity nucleus
YIR024C YIR024C YIR024C hom Verified 0.981838490656792 0.163089711166836 no 807 0.176672123434546 599 NA FT MITOCHONDRION Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; interacts with Arh1p, a mitochondrial oxidoreductase; deletion mutant has a respiratory growth defect biological_process molecular_function mitochondrion
YLR455W YLR455W YLR455W hom Verified 0.98155327027557 0.163159989265885 no 808 0.179280840288121 648 NA FT NUCLEUS Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus
YPR079W YPR079W MRL1 hom Verified 0.979298402762523 0.163716279713587 no 809 0.148671292080717 499 NA FT PROTEIN LOCALIZATION|VACUOLAR TRANSPORT GOLGI APPARATUS Membrane protein; has similarity to mammalian mannose-6-phosphate receptors; possibly functions as a sorting receptor in the delivery of vacuolar hydrolases; protein abundance increases in response to DNA replication stress vacuolar transport signal sequence binding late endosome|cytoplasm
YBR019C YBR019C GAL10 hom Verified 0.978716928659673 0.163859932602692 no 810 0.154313323409108 564 NA FT CARBOHYDRATE METABOLISM UDP-glucose-4-epimerase, catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes the conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers galactose catabolic process via UDP-galactose aldose 1-epimerase activity|UDP-glucose 4-epimerase activity cytosol
YOL068C YOL068C HST1 hom Verified 0.978614042988285 0.1638853589717 no 811 0.174270420095147 637 NA FT CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME NAD(+)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing and mitotic repression; non-essential subunit of the Set3C deacetylase complex; involved in telomere maintenance chromatin silencing|negative regulation of mitotic recombination|histone deacetylation NAD-independent histone deacetylase activity|NAD-dependent histone deacetylase activity Set3 complex
YOL091W YOL091W SPO21 hom Verified 0.978449870240036 0.163925936656828 no 812 0.149092939162662 534 NA FT CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION CYTOSKELETON Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation ascospore wall assembly|meiosis structural molecule activity spindle pole body
YPL261C_d YPL261C YPL261C hom Dubious 0.977694076213453 0.16411282623676 no 813 0.159951331011246 603 NA Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YPL260W Unknown Unknown Unknown
YER049W YER049W TPA1 hom Verified 0.976310980408017 0.164455190098909 no 814 0.140377493384515 463 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|OXIDATION-REDUCTION PROCESS NUCLEUS Poly(rA)-binding protein involved in translation termination efficiency, mRNA poly(A) tail length and mRNA stability; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; similar to prolyl 4-hydroxylases; binds Fe(III) and 2-oxoglutarate nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|translational termination poly(A) RNA binding nucleus
YGR028W YGR028W MSP1 hom Verified 0.974139405619084 0.164993663047804 no 815 0.146047691245719 472 NA FT PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial protein involved in sorting of proteins in the mitochondria; putative membrane-spanning ATPase protein targeting to mitochondrion ATPase activity mitochondrial outer membrane|mitochondrion
YDR507C YDR507C GIN4 hom Verified 0.971800957613341 0.165574789692608 no 816 0.171627227972143 636 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION SITE OF POLARIZED GROWTH Protein kinase involved in bud growth and assembly of the septin ring; proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Hsl1p; GIN4 has a paralog, KCC4, that arose from the whole genome duplication protein autophosphorylation|budding cell bud growth|protein phosphorylation|septin checkpoint|septin ring assembly protein kinase activity cellular bud neck
YDR075W YDR075W PPH3 hom Verified 0.971225622430008 0.165717968639981 no 817 0.140285208778999 519 NA FT CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Catalytic subunit of protein phosphatase PP4 complex; active complex is composed of Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; involved in activation of Gln3p to alleviate nitrogen catabolite repression; Pph3p and Psy2p localize to foci on meiotic chromosomes Unknown|signal transduction involved in meiotic recombination checkpoint|double-strand break repair via homologous recombination|protein dephosphorylation|positive regulation of nitrogen compound metabolic process protein serine/threonine phosphatase activity condensed nuclear chromosome|nucleus|cytoplasm
YLR232W_d YLR232W YLR232W hom Dubious 0.970041493172252 0.166012905025725 no 818 0.148569520878921 492 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene BNA5 Unknown Unknown Unknown
YPL259C YPL259C APM1 hom Verified 0.969043977272653 0.166261623839067 no 819 0.197100370084244 685 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Mu1-like medium subunit of the clathrin-associated protein complex (AP-1); binds clathrin; involved in clathrin-dependent Golgi protein sorting Golgi to vacuole transport|vesicle-mediated transport clathrin binding AP-1 adaptor complex
YLL028W YLL028W TPO1 hom Verified 0.967329693178382 0.166689622223071 no 820 0.119646952941524 418 NA FT PLASMA MEMBRANE Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane spermidine transport|putrescine transport|spermine transport spermidine transmembrane transporter activity|spermine transmembrane transporter activity fungal-type vacuole membrane|integral to membrane|cellular bud membrane|plasma membrane
YBR095C YBR095C RXT2 hom Verified 0.966631241784916 0.166864205427198 no 821 0.20284134519073 704 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Subunit of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth conjugation with cellular fusion|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of transcription from RNA polymerase II promoter|negative regulation of chromatin silencing at telomere|negative regulation of chromatin silencing at rDNA|invasive growth in response to glucose limitation histone deacetylase activity Rpd3L-Expanded complex|nucleus|Rpd3L complex
YDL066W YDL066W IDP1 hom Verified 0.966285898872186 0.166950570060542 no 822 0.25246322886064 884 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes isocitrate metabolic process|glutamate biosynthetic process isocitrate dehydrogenase (NADP+) activity mitochondrial nucleoid|mitochondrion
YDR503C YDR503C LPP1 hom Verified 0.965909900602367 0.167044633875297 no 823 0.144867956580963 500 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Lipid phosphate phosphatase, catalyzes Mg(2+)-independent dephosphorylation of phosphatidic acid (PA), lysophosphatidic acid, and diacylglycerol pyrophosphate; involved in control of the cellular levels of phosphatidylinositol and PA phospholipid metabolic process phosphatidate phosphatase activity integral to membrane|membrane
YPL187W YPL187W MF(ALPHA)1 hom Verified 0.964040868697026 0.167512718259788 no 824 0.170137735285994 585 NA FT SIGNALING Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)2, although MF(ALPHA)1 produces most alpha-factor pheromone-dependent signal transduction involved in conjugation with cellular fusion mating pheromone activity extracellular region
YOR193W YOR193W PEX27 hom Verified 0.962820690612798 0.167818757743847 no 825 0.162909730133547 530 NA FT PEROXISOME ORGANIZATION Peripheral peroxisomal membrane protein involved in controlling peroxisome size and number, interacts with homologous protein Pex25p peroxisome organization molecular_function peroxisomal membrane
YMR180C YMR180C CTL1 hom Verified 0.962475622977357 0.167905371285383 no 826 0.151583066196598 513 NA FT RNA PROCESSING NUCLEUS RNA 5'-triphosphatase, localizes to both the nucleus and cytoplasm biological_process polynucleotide 5'-phosphatase activity nucleus|cytoplasm
YHL047C YHL047C ARN2 hom Verified 0.961325895387703 0.168194165750623 no 827 0.161301239865043 568 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS|COFACTOR METABOLISM PLASMA MEMBRANE Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C cellular iron ion homeostasis|siderophore transport|siderophore metabolic process siderophore transmembrane transporter activity endosome|integral to membrane|cytoplasmic membrane-bounded vesicle|plasma membrane
YPL073C_d YPL073C YPL073C hom Dubious 0.960302840802604 0.168451410370593 no 828 0.148960080156626 512 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps with verified gene UBP16/YPL072W; may interact with ribosome based on co-purification experiments Unknown Unknown Unknown
YPR009W YPR009W SUT2 hom Verified 0.959713931499246 0.168599604870955 no 829 0.183075832514113 583 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1p positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter RNA polymerase II repressing transcription factor binding|sequence-specific DNA binding nucleus
YOR109W YOR109W INP53 hom Verified 0.95737822652775 0.169188192133358 no 830 0.162836302579988 596 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION CYTOSKELETON Polyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains phosphatidylinositol dephosphorylation phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|phosphatidylinositol-3-phosphatase activity|phosphatidylinositol-4-phosphate phosphatase activity membrane|actin cortical patch|cytoplasm
YOR213C YOR213C SAS5 hom Verified 0.957236549659858 0.169223936462651 no 831 0.191417396836805 668 NA FT CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME HISTONE ACETYLTRANSFERASE Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity chromatin silencing at telomere acetyltransferase activity|histone acetyltransferase activity nuclear chromatin|SAS acetyltransferase complex|nuclear chromosome, telomeric region
YPR061C YPR061C JID1 hom Verified 0.956782037328281 0.169338640258533 no 832 0.163790416394894 610 NA FT MITOCHONDRION Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae biological_process molecular_function mitochondrion
YFL018C YFL018C LPD1 hom Verified 0.954266342735969 0.169974420155341 no 833 0.168306984744828 597 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION Dihydrolipoamide dehydrogenase, the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes L-serine biosynthetic process|2-oxoglutarate metabolic process|leucine catabolic process|glycine catabolic process|isoleucine catabolic process|pyruvate metabolic process|valine catabolic process|hydrogen peroxide metabolic process glycine dehydrogenase (decarboxylating) activity|pyruvate dehydrogenase activity|oxoglutarate dehydrogenase (succinyl-transferring) activity|dihydrolipoyl dehydrogenase activity mitochondrial nucleoid|mitochondrion|glycine cleavage complex|mitochondrial oxoglutarate dehydrogenase complex
YOR384W YOR384W FRE5 hom Verified 0.954030097388869 0.170034203847957 no 834 0.190138481158352 647 NA FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION|PLASMA MEMBRANE Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process ferric-chelate reductase activity mitochondrion|integral to membrane
YDL086W_p YDL086W YDL086W hom Uncharacterized 0.953828752142693 0.170085166439793 no 835 0.124043790613343 449 NA FT MITOCHONDRION Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene biological_process carboxymethylenebutenolidase activity mitochondrion|cytoplasm
YOR087W YOR087W YVC1 hom Verified 0.953369676450769 0.170201399909451 no 836 0.156555463722054 481 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Vacuolar cation channel, mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock cellular cation homeostasis voltage-gated ion channel activity|calcium activated cation channel activity|sodium channel activity|calcium channel activity|potassium channel activity fungal-type vacuole membrane|fungal-type vacuole
YGR050C_p YGR050C YGR050C hom Uncharacterized 0.953310595962556 0.170216362206104 no 837 0.153058286356505 608 NA Protein of unknown function; mRNA identified as translated by ribosome profiling data biological_process molecular_function cellular_component
YKL096W-A YKL096W-A CWP2 hom Verified 0.952296960101551 0.170473199542283 no 838 0.17152486101114 613 NA FT ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored fungal-type cell wall organization|regulation of pH structural constituent of cell wall fungal-type cell wall
YNL191W YNL191W DUG3 hom Verified 0.951231942216803 0.170743323389789 no 839 0.158808774857538 559 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Component of glutamine amidotransferase (GATase II); forms a complex with Dug2p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p) glutathione catabolic process peptidase activity|omega peptidase activity|gamma-glutamyltransferase activity|carbon-nitrogen ligase activity, with glutamine as amido-N-donor cytoplasm
YDR046C YDR046C BAP3 hom Verified 0.951041201860775 0.170791730378009 no 840 0.152620985528934 497 NA FT MITOCHONDRION|PLASMA MEMBRANE Amino acid permease; involved in uptake of cysteine, leucine, isoleucine and valine; BAP3 has a paralog, BAP2, that arose from the whole genome duplication amino acid transport|transmembrane transport amino acid transmembrane transporter activity mitochondrion|integral to membrane|plasma membrane
YDL081C YDL081C RPP1A hom Verified 0.949596735765884 0.171158598863949 no 841 0.166704567165704 565 NA FT TRANSLATION RIBOSOME Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component cytoplasmic translation|translational elongation structural constituent of ribosome cytosolic large ribosomal subunit
YDR290W_d YDR290W YDR290W hom Dubious 0.949258784393289 0.171244505145067 no 842 0.207671832702819 691 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RTT103 Unknown Unknown Unknown
YJR039W_p YJR039W YJR039W hom Uncharacterized 0.944700581890373 0.172405879944338 no 843 0.135742816258571 500 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YDR486C YDR486C VPS60 hom Verified 0.943883567585751 0.172614575038259 no 844 0.183630099011272 647 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT Cytoplasmic and vacuolar membrane protein involved in late endosome to vacuole transport; required for normal filament maturation during pseudohyphal growth; may function in targeting cargo proteins for degradation; interacts with Vta1p late endosome to vacuole transport via multivesicular body sorting pathway|filamentous growth molecular_function fungal-type vacuole membrane|cytoplasm
YMR293C YMR293C HER2 hom Verified 0.9432080560809 0.172787246772847 no 845 0.187418429887238 672 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION MITOCHONDRION Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase endoplasmic reticulum organization|glutaminyl-tRNAGln biosynthesis via transamidation glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity mitochondrion|glutamyl-tRNA(Gln) amidotransferase complex
YPL183C YPL183C RTT10 hom Verified 0.942978796827739 0.172845874182815 no 846 0.179044237814478 619 NA FT VESICLE-MEDIATED TRANSPORT WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rrt2p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; evidence it interacts with Trm7p for 2'-O-methylation of N34 of substrate tRNAs; has a role in regulation of Ty1 transposition; human ortholog is WDR6 endocytic recycling molecular_function endosome|cytoplasm
YNR066C_p YNR066C YNR066C hom Uncharacterized 0.942617839743419 0.172938205760489 no 847 0.174061362552113 643 NA Putative membrane-localized protein of unknown function biological_process molecular_function integral to membrane|membrane
YMR066W YMR066W SOV1 hom Verified 0.942494476639114 0.172969768821616 no 848 0.193144403774061 657 NA FT MITOCHONDRION Mitochondrial protein of unknown function biological_process molecular_function mitochondrion
YBR168W YBR168W PEX32 hom Verified 0.942421976116325 0.172988320151628 no 849 0.187700345133951 644 NA FT PEROXISOME ORGANIZATION Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p peroxisome organization molecular_function integral to membrane|integral to peroxisomal membrane
YOR309C_d YOR309C YOR309C hom Dubious 0.942399621767434 0.172994040406104 no 850 0.198263343001717 674 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58 Unknown Unknown Unknown
YML128C YML128C MSC1 hom Verified 0.94158893567502 0.173201568302262 no 851 0.183908507914798 603 NA FT CELL CYCLE ENDOPLASMIC RETICULUM|MITOCHONDRION Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated reciprocal meiotic recombination molecular_function mitochondrion|endoplasmic reticulum|plasma membrane
YKL175W YKL175W ZRT3 hom Verified 0.941080517346703 0.173331799396663 no 852 0.155685248659908 485 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Vacuolar membrane zinc transporter, transports zinc from storage in the vacuole to the cytoplasm when needed; transcription is induced under conditions of zinc deficiency cellular zinc ion homeostasis|zinc ion transport zinc ion transmembrane transporter activity fungal-type vacuole membrane|integral to membrane
YJR118C YJR118C ILM1 hom Verified 0.941021161031611 0.173347007549356 no 853 0.212365875825354 743 NA FF|FT MITOCHONDRION ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth mitochondrial genome maintenance molecular_function integral to membrane|endoplasmic reticulum
YMR253C_p YMR253C YMR253C hom Uncharacterized 0.940861560109607 0.173387904381511 no 854 0.166205527749696 613 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene biological_process molecular_function integral to membrane|cytoplasm
YNR009W YNR009W NRM1 hom Verified 0.940273819507779 0.173538562532983 no 855 0.16094279461824 545 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE NUCLEUS Transcriptional co-repressor of MBF (MCB binding factor)-regulated gene expression; Nrm1p associates stably with promoters via MBF to repress transcription upon exit from G1 phase negative regulation of transcription involved in G1 phase of mitotic cell cycle repressing transcription factor binding|transcription factor binding transcription factor activity MBF transcription complex|nucleus|cytoplasm
YER020W YER020W GPA2 hom Verified 0.939894225718421 0.173635909754174 no 856 0.160865610698839 553 NA FT SIGNALING|NUCLEOTIDE METABOLISM MITOCHONDRION|PLASMA MEMBRANE Nucleotide binding alpha subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p, has signaling role in response to nutrients; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery adenylate cyclase-activating G-protein coupled receptor signaling pathway|ascospore formation|replicative cell aging|signal transduction|glucose mediated signaling pathway|pseudohyphal growth|hexose mediated signaling|regulation of cell size GTPase activity mitochondrion|plasma membrane
YPR133W-A YPR133W-A TOM5 hom Verified 0.939717236175739 0.173681310780479 no 857 0.166434076223785 558 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import of all mitochondrially directed proteins; involved in transfer of precursors from the Tom70p and Tom20p receptors to the Tom40p pore mitochondrial outer membrane translocase complex assembly|protein targeting to mitochondrion protein channel activity mitochondrial outer membrane|mitochondrion|integral to membrane|integral to mitochondrial outer membrane|mitochondrial outer membrane translocase complex
YDR513W YDR513W GRX2 hom Verified 0.939638873749421 0.173701414575406 no 858 0.15644895864116 518 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS MITOCHONDRION Cytoplasmic glutaredoxin; thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity, expression induced in response to stress; GRX2 has a paralog, GRX1, that arose from the whole genome duplication cellular response to oxidative stress disulfide oxidoreductase activity|glutathione transferase activity|glutathione peroxidase activity cytosol|mitochondrion
YML108W YML108W YML108W hom Verified 0.939634185505408 0.173702617386222 no 859 0.148902560169628 479 NA FT NUCLEUS Protein of unknown function; structure defines a new subfamily of the split beta-alpha-beta sandwiches; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YML108W is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress biological_process molecular_function nucleus|cytoplasm
YBR266C_d YBR266C SLM6 hom Dubious 0.939017239225124 0.173860946683173 no 860 0.181772251620396 599 NA Protein with a potential role in actin cytoskeleton organization; gene exhibits synthetic genetic interaction with MSS4 encoding phosphatidylinositol 4-phosphate kinase Unknown Unknown Unknown
YBR189W YBR189W RPS9B hom Verified 0.937838161718061 0.174163793106532 no 861 0.173346165190066 579 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION NUCLEUS RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog, RPS9A, that arose from the whole genome duplication positive regulation of translational fidelity|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome small-subunit processome|cytosolic small ribosomal subunit|90S preribosome
YJR106W YJR106W ECM27 hom Verified 0.937069426717135 0.174361423376881 no 862 0.146507549562918 471 NA FT CELL WALL ORG/BIOGENESIS Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants are hypersensitive to Papulacandin B; null mutants have increased plasmid loss; displays a two-hybrid interaction with Pdr5p fungal-type cell wall organization molecular_function integral to membrane
YNR031C YNR031C SSK2 hom Verified 0.936600969542349 0.174481926546893 no 863 0.172185878283611 628 NA FT SIGNALING|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION SITE OF POLARIZED GROWTH MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress MAPK cascade involved in osmosensory signaling pathway|protein autophosphorylation|protein phosphorylation|response to osmotic stress|actin cytoskeleton organization|osmosensory signaling pathway via two-component system MAP kinase kinase kinase activity cytosol|cellular bud neck|cellular bud tip
YGL151W YGL151W NUT1 hom Verified 0.936580309732764 0.174487242172447 no 864 0.168672940236816 598 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS|MITOCHONDRION Component of the RNA polymerase II mediator complex, which is required for transcriptional activation and also has a role in basal transcription regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter molecular_function mitochondrion|mediator complex|nucleus
YDL211C_p YDL211C YDL211C hom Uncharacterized 0.93536119566785 0.174801093856895 no 865 0.173765569388751 600 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole biological_process molecular_function fungal-type vacuole
YDR144C YDR144C MKC7 hom Verified 0.933667540259519 0.175237706907571 no 866 0.171061231758977 616 NA FT CELL WALL ORG/BIOGENESIS|PROTEOLYSIS PLASMA MEMBRANE GPI-anchored aspartyl protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; shares functions with Yap3p and Kex2p proteolysis|fungal-type cell wall organization aspartic-type endopeptidase activity fungal-type cell wall
YDR119W_p YDR119W VBA4 hom Uncharacterized 0.93275968857263 0.17547202947564 no 867 0.139805048465312 467 NA Protein of unknown function with proposed role as a basic amino acid permease based on phylogeny; GFP-fusion protein localizes to vacuolar membrane; physical interaction with Atg27p suggests a possible role in autophagy; non-essential gene biological_process molecular_function fungal-type vacuole membrane|integral to membrane
YER091C-A_d YER091C-A YER091C-A hom Dubious 0.932207347671727 0.175614689470256 no 868 0.191690222492498 658 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPL120W YPL120W VPS30 hom Verified 0.931513982198286 0.175793877652955 no 869 0.184076138015982 661 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy and Complex II is required for vacuolar protein sorting; required for overflow degradation of misfolded proteins when ERAD is saturated; ortholog of the higher eukaryotic gene Beclin 1 phosphatidylinositol biosynthetic process|piecemeal microautophagy of nucleus|ER-associated protein catabolic process|peroxisome degradation|retrograde transport, endosome to Golgi|macroautophagy|CVT pathway|late endosome to vacuole transport 1-phosphatidylinositol-3-kinase activity phosphatidylinositol 3-kinase complex I|phosphatidylinositol 3-kinase complex II|extrinsic to membrane|cytoplasm
YGL163C YGL163C RAD54 hom Verified 0.930924680652316 0.175946263345591 no 870 0.242898280999731 809 NA FF|FT CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS DNA-dependent ATPase that stimulates strand exchange; modifies the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family; forms nuclear foci upon DNA replication stress positive regulation of endodeoxyribonuclease activity|DNA geometric change|heteroduplex formation|telomere maintenance via recombination|double-strand break repair via synthesis-dependent strand annealing|chromatin remodeling|double-strand break repair via single-strand annealing DNA-dependent ATPase activity|DNA translocase activity nucleus
YCR059C YCR059C YIH1 hom Verified 0.929662351351436 0.17627296663583 no 871 0.17388436068814 616 NA FT TRANSLATION|PROTEIN PHOSPHORYLATION NUCLEUS Negative regulator of eIF2 kinase Gcn2p; competes with Gcn2p for binding to Gcn1p; may contribute to regulation of translation in response to starvation via regulation of Gcn2p; binds to monomeric actin and to ribosomes and polyribosomes; ortholog of mammalian IMPACT negative regulation of protein phosphorylation protein kinase inhibitor activity|ribosome binding|actin monomer binding ribosome|nucleus|polysome|cytoplasm
YFL010W-A YFL010W-A AUA1 hom Verified 0.929482584341523 0.176319523320866 no 872 0.189019757105883 621 NA Protein required for the negative regulation by ammonia of Gap1p, which is a general amino acid permease amino acid transport molecular_function cellular_component
YDR469W YDR469W SDC1 hom Verified 0.929431846567676 0.17633266497366 no 873 0.205795226124616 695 NA FT CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS Subunit of the COMPASS (Set1C) complex, which methylates lysine 4 of histone H3 and is required in chromatin silencing at telomeres; contains a Dpy-30 domain that mediates interaction with Bre2p; similar to C. elegans and human DPY-30 histone H3-K4 methylation|chromatin silencing at telomere histone methyltransferase activity (H3-K4 specific) Set1C/COMPASS complex
YOR115C YOR115C TRS33 hom Verified 0.929062533674794 0.176428339829904 no 874 0.167363689637812 620 NA FT VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS ENDOPLASMIC RETICULUM|GOLGI APPARATUS One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic ER to Golgi vesicle-mediated transport|protein complex assembly molecular_function trans-Golgi network|TRAPP complex|cis-Golgi network
YHR140W_p YHR140W YHR140W hom Uncharacterized 0.927921146013896 0.176724237284915 no 875 0.154758830461272 557 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Putative integral membrane protein of unknown function biological_process molecular_function integral to membrane
YDR014W YDR014W RAD61 hom Verified 0.926563112990696 0.177076707138908 no 876 0.199775012038011 662 NA FT CELL CYCLE|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Subunit of a complex (Scc3p, Pds5p, Rad61p) that inhibits sister chromatid cohesion; inhibited by Eco1p-acetylated cohesin subunits Smc3p and Mcd1p; related to the human Wapl protein that controls the association of cohesin with chromatin mitotic sister chromatid cohesion molecular_function nuclear cohesin complex
YNL278W YNL278W CAF120 hom Verified 0.9263258476728 0.177138333565315 no 877 0.165459106798477 567 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS|SITE OF POLARIZED GROWTH Part of the CCR4-NOT transcriptional regulatory complex; involved in controlling mRNA initiation, elongation, and degradation; CAF120 has a paralog, SKG3, that arose from the whole genome duplication regulation of transcription from RNA polymerase II promoter molecular_function CCR4-NOT complex
YBR063C_p YBR063C YBR063C hom Uncharacterized 0.926253173936144 0.177157212286049 no 878 0.161178170566945 568 NA Putative protein of unknown function; YBR063C is not an essential gene biological_process molecular_function cellular_component
YGL063W YGL063W PUS2 hom Verified 0.925364134568547 0.177388264136807 no 879 0.173490149964983 600 NA FT RNA PROCESSING MITOCHONDRION Mitochondrial tRNA:pseudouridine synthase; acts at positions 27 and 28, but not at position 72; efficiently and rapidly targeted to mitochondria, specifically dedicated to mitochondrial tRNA modification tRNA pseudouridine synthesis pseudouridine synthase activity mitochondrion
YDL109C_p YDL109C YDL109C hom Uncharacterized 0.924787814144751 0.177538145262267 no 880 0.191353300282 693 NA FT LIPID METABOLISM Putative lipase; involved in lipid metabolism; not an essential gene; YDL109C has a paralog, ROG1, that arose from the whole genome duplication cellular lipid metabolic process molecular_function cellular_component
YDR022C YDR022C ATG31 hom Verified 0.924390350167183 0.177641558532012 no 881 0.166748639297874 578 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|CHROMOSOME SEGREGATION CYTOSKELETON Autophagy-specific protein required for autophagosome formation; may form a complex with Atg17p and Atg29p that localizes other proteins to the pre-autophagosomal structure; high-copy suppressor of CIK1 deletion autophagy|mitochondrion degradation|piecemeal microautophagy of nucleus molecular_function pre-autophagosomal structure|cytoplasm
YGR170W YGR170W PSD2 hom Verified 0.924189565815154 0.17769381360412 no 882 0.179535008162204 586 NA FT LIPID METABOLISM GOLGI APPARATUS Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes, converts phosphatidylserine to phosphatidylethanolamine phosphatidylcholine biosynthetic process phosphatidylserine decarboxylase activity endosome
YGR121W-A_p YGR121W-A YGR121W-A hom Uncharacterized 0.924065559800373 0.177726091596943 no 883 0.17084976530913 566 NA Putative protein of unknown function biological_process molecular_function cellular_component
YER039C-A_p YER039C-A YER039C-A hom Uncharacterized 0.924010961311529 0.177740304416155 no 884 0.173218319326382 611 NA Putative protein of unknown function; YER039C-A is not an essential gene biological_process molecular_function integral to membrane
YBR284W_p YBR284W YBR284W hom Uncharacterized 0.92379844866861 0.177795631524704 no 885 0.181236085099691 642 NA FT NUCLEOTIDE METABOLISM Putative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic defect of quadruple aah1 ade8 amd1 his1 mutant; null mutant exhibits longer telomeres, altered Ty mobility, decreased resistance to rapamycin and wortmannin; induced in response to hydrostatic pressure; not an essential gene; YBR284W has a paralog, YJL070C, that arose from the whole genome duplication biological_process AMP deaminase activity|molecular_function cellular_component
YKL048C YKL048C ELM1 hom Verified 0.922323874688881 0.178179832158139 no 886 0.182229433727061 675 NA FT CELL CYCLE|CELL DIVISION|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION SITE OF POLARIZED GROWTH|CYTOSKELETON Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases, such as Kin4p; forms part of the bud neck ring positive regulation of protein autophosphorylation|protein autophosphorylation|cell morphogenesis|budding cell bud growth|protein phosphorylation|response to drug|septin checkpoint|pseudohyphal growth|glucose metabolic process|axial cellular bud site selection|response to osmotic stress|cytokinesis protein serine/threonine kinase activity|protein kinase activity cellular bud neck contractile ring
YHR139C-A_d YHR139C-A YHR139C-A hom Dubious 0.921262677099184 0.178456651026914 no 887 0.168572015598746 599 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YJL192C YJL192C SOP4 hom Verified 0.920420151124746 0.178676621098593 no 888 0.241703250794879 828 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM ER-membrane protein; suppressor of pma1-7, deletion of SOP4 slows down the export of wild-type Pma1p and Pma1-7 from the ER ER to Golgi vesicle-mediated transport molecular_function integral to membrane|endoplasmic reticulum
YGL017W YGL017W ATE1 hom Verified 0.920343163839623 0.178696729758209 no 889 0.155072282800297 508 NA FT PROTEOLYSIS Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway cellular protein modification process|protein arginylation arginyltransferase activity cytoplasm
YGR062C YGR062C COX18 hom Verified 0.919974823574785 0.178792957945579 no 890 0.178515833936899 625 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial integral inner membrane protein required for membrane insertion of C-terminus of Cox2p; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC protein insertion into mitochondrial membrane from inner side membrane insertase activity integral to membrane|integral to mitochondrial inner membrane
YDL083C YDL083C RPS16B hom Verified 0.919834915206829 0.178829517284925 no 891 0.206797389734814 673 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16B has a paralog, RPS16A, that arose from the whole genome duplication cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome cytosolic small ribosomal subunit
YGL231C YGL231C EMC4 hom Verified 0.919598684512731 0.17889125721061 no 892 0.202593269176204 678 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm ZK616.6/EMC-4, fly CG11137, human TMM85 protein folding in endoplasmic reticulum molecular_function ER membrane protein complex|endoplasmic reticulum
YBR157C YBR157C ICS2 hom Verified 0.91936940268654 0.178951193846889 no 893 0.167558267526703 549 NA Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization biological_process molecular_function cellular_component
YDR538W YDR538W PAD1 hom Verified 0.9191867453616 0.178998951399965 no 894 0.169162198720478 641 NA FT KETONE METABOLISM MITOCHONDRION Phenylacrylic acid decarboxylase, confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives; also has mRNA binding activity; homolog of E. coli UbiX cinnamic acid catabolic process|aromatic compound catabolic process mRNA binding|carboxy-lyase activity mitochondrion
YBR098W YBR098W MMS4 hom Verified 0.918958295999868 0.179058693017665 no 895 0.167407485902009 591 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p DNA repair|DNA topological change|regulation of reciprocal meiotic recombination|reciprocal meiotic recombination|resolution of meiotic recombination intermediates|response to DNA damage stimulus transcription coactivator activity|endonuclease activity|crossover junction endodeoxyribonuclease activity Holliday junction resolvase complex|nucleus
YGR223C YGR223C HSV2 hom Verified 0.917530828281206 0.179432273044255 no 896 0.186222590725 646 NA FT MEMBRANE ORGANIZATION|RESPONSE TO NUTRIENT LEVELS Phosphatidylinositol 3,5-bisphosphate-binding protein, plays a role in micronucleophagy; belongs to the PROPPIN family of proteins; predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization piecemeal microautophagy of nucleus phosphatidylinositol binding endosome|fungal-type vacuole|extrinsic to membrane|cytoplasm
YPR164W YPR164W MMS1 hom Verified 0.915611152412664 0.179935439924211 no 897 0.1826604826258 663 NA FT RESPONSE TO DNA DAMAGE NUCLEUS UBIQUITIN LIGASE COMPLEX Subunit of an E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of the replication fork such as the fork-pausing complex and leading strand polymerase, preventing fork collapse and promoting efficient recovery during replication stress; regulates Ty1 transposition; involved with Rtt101p in nonfunctional rRNA decay replication fork processing|negative regulation of transposition, RNA-mediated|recombinational repair|nonfunctional rRNA decay molecular_function Cul8-RING ubiquitin ligase complex
YBL010C_p YBL010C YBL010C hom Uncharacterized 0.912148026182683 0.180845399728431 no 898 0.178151933016462 626 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles biological_process molecular_function clathrin-coated vesicle
YLR119W YLR119W SRN2 hom Verified 0.911189838973948 0.18109767844996 no 899 0.189569080717569 658 NA FT PROTEIN LOCALIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus protein targeting to membrane|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein targeting to vacuole protein binding endosome|ESCRT I complex
YIL132C YIL132C CSM2 hom Verified 0.9089304243321 0.181693426450239 no 900 0.148225354896646 509 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function; structural analysis reveals a similar DNA-binding region in both Psy3p and Csm2p and that both regions work together to form a single DNA binding site; required for accurate chromosome segregation during meiosis meiotic chromosome segregation|recombinational repair|maintenance of rDNA|error-free translesion synthesis molecular_function nucleus|Shu complex|cytoplasm
YOR314W_d YOR314W YOR314W hom Dubious 0.907881695751866 0.181970364686436 no 901 0.175545808531208 636 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YFL049W YFL049W SWP82 hom Verified 0.907529188616698 0.182063510648248 no 902 0.167118435450602 559 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION NUCLEUS RSC COMPLEX Member of the SWI/SNF chromatin remodeling complex; has an as yet unidentified role in the complex; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p; relocates to the cytosol under hypoxic conditions positive regulation of transcription from RNA polymerase II promoter molecular_function SWI/SNF complex|nucleus
YBR053C_p YBR053C YBR053C hom Uncharacterized 0.907505029308241 0.182069895559337 no 903 0.158369938280489 514 NA Putative protein of unknown function; induced by cell wall perturbation biological_process molecular_function cellular_component
YMR069W YMR069W NAT4 hom Verified 0.907322388111981 0.182118169177287 no 904 0.204658510716544 688 NA FT CHROMATIN ORGANIZATION NUCLEUS N alpha-acetyl-transferase, involved in acetylation of the N-terminal residues of histones H4 and H2A histone acetylation histone acetyltransferase activity nucleus|cytoplasm
YDL162C_d YDL162C YDL162C hom Dubious 0.906889373271033 0.182232650641826 no 905 0.179281416330973 601 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps ENT1/YDL161W, a verified gene involved in endocytosis and actin cortical patch assembly Unknown Unknown Unknown
YDR126W YDR126W SWF1 hom Verified 0.906381766597067 0.182366910118465 no 906 0.205041647627609 702 NA FF|FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|CYTOSKELETON Palmitoyltransferase that acts on transmembrane proteins, including the SNAREs Snc1p, Syn8p, Tlg1p and likely all SNAREs; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; may have a role in vacuole fusion ascospore wall assembly|cortical actin cytoskeleton organization|establishment of cell polarity|vacuole fusion, non-autophagic|regulation of exocytosis|protein palmitoylation palmitoyltransferase activity integral to membrane|actin filament bundle|nuclear outer membrane-endoplasmic reticulum membrane network|actin cortical patch
YGL079W_p YGL079W KXD1 hom Uncharacterized 0.905434209781891 0.182617699562064 no 907 0.168081007185691 561 NA Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; GFP-fusion protein localizes to the endosome biological_process molecular_function endosome
YDL035C YDL035C GPR1 hom Verified 0.90524833405301 0.182666920464687 no 908 0.20869379009484 702 NA FT SIGNALING PLASMA MEMBRANE Plasma membrane G protein coupled receptor (GPCR) that interacts with the heterotrimeric G protein alpha subunit, Gpa2p, and with Plc1p; sensor that integrates nutritional signals with the modulation of cell fate via PKA and cAMP synthesis replicative cell aging|G-protein coupled receptor signaling pathway|sucrose mediated signaling|glucose mediated signaling pathway|pseudohyphal growth|hexose mediated signaling|invasive growth in response to glucose limitation|detection of glucose|detection of sucrose stimulus G-protein coupled receptor activity|glucose binding integral to membrane|plasma membrane
YHR057C YHR057C CPR2 hom Verified 0.904897658495031 0.182759803810652 no 909 0.174755962544782 573 NA Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway biological_process peptidyl-prolyl cis-trans isomerase activity cellular_component
YGR059W YGR059W SPR3 hom Verified 0.904879789995478 0.182764537424918 no 910 0.179891031355071 624 NA FT CELL CYCLE SITE OF POLARIZED GROWTH|CYTOSKELETON Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; septin protein involved in sporulation; regulated by ABFI ascospore formation structural molecule activity septin complex|ascospore wall|prospore membrane
YML059C YML059C NTE1 hom Verified 0.904643195441956 0.182827221831542 no 911 0.181980712820174 623 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Serine esterase, homolog of human neuropathy target esterase (NTE); Nte1p-mediated phosphatidylcholine turnover influences transcription factor Opi1p localization, affecting transcriptional regulation of phospholipid biosynthesis genes phosphatidylcholine catabolic process|regulation of phospholipid biosynthetic process lysophospholipase activity|carboxylesterase activity integral to membrane|endoplasmic reticulum
YCL051W YCL051W LRE1 hom Verified 0.904567116702896 0.18284738131996 no 912 0.198097114294287 699 NA FT CELL WALL ORG/BIOGENESIS Protein involved in control of cell wall structure and stress response; overproduction confers resistance to cell-wall degrading enzymes; exhibits genetic interactions with genes involved in the cell wall integrity pathway;
LRE1 has a paralog, HLR1, that arose from the whole genome duplication fungal-type cell wall organization molecular_function cellular_component
YPL038W YPL038W MET31 hom Verified 0.904390017956143 0.182894314655189 no 913 0.185441563222348 656 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; MET31 has a paralog, MET32, that arose from the whole genome duplication regulation of sulfur amino acid metabolic process|regulation of transcription from RNA polymerase II promoter core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity nucleus|cytoplasm
YBL102W YBL102W SFT2 hom Verified 0.904183816177523 0.18294897012237 no 914 0.201651575409397 683 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Non-essential tetra-spanning membrane protein found mostly in the late Golgi, can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to mammalian syntaxin 5 Golgi to endosome transport molecular_function integral to membrane|Golgi membrane
YDR296W YDR296W MHR1 hom Verified 0.903270535443002 0.183191165168044 no 915 0.206331296661891 699 NA FT MITOCHONDRION ORGANIZATION|RESPONSE TO OXIDATIVE STRESS NUCLEUS|MITOCHONDRION Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress cellular response to oxidative stress|positive regulation of mitochondrial DNA replication|regulation of transcription, DNA-dependent|mitochondrial genome maintenance|DNA recombination single-stranded DNA binding|recombinase activity|DNA binding mitochondrion|nucleus
YDR458C YDR458C HEH2 hom Verified 0.902472451943569 0.183402974442866 no 916 0.190815250607686 694 NA FT ENDOMEMBRANE SYSTEM|NUCLEUS Inner nuclear membrane (INM) protein; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence; targeting to the INM requires the Srp1p-Kap95p karyopherins and the Ran cycle biological_process molecular_function nuclear envelope
YDR446W YDR446W ECM11 hom Verified 0.901872415383044 0.183562323082131 no 917 0.139932472484905 481 NA FT CELL CYCLE|CELL WALL ORG/BIOGENESIS NUCLEUS Non-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure fungal-type cell wall organization|reciprocal meiotic recombination molecular_function nucleus
YPL090C YPL090C RPS6A hom Verified 0.900387441387032 0.183957050882984 no 918 0.187883066491537 642 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; RPS6A has a paralog, RPS6B, that arose from the whole genome duplication cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) structural constituent of ribosome small-subunit processome|cytosolic small ribosomal subunit|90S preribosome
YCR046C YCR046C IMG1 hom Verified 0.895918395787675 0.185148174224972 no 919 0.191969588466855 661 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit, required for respiration and for maintenance of the mitochondrial genome mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YDR097C YDR097C MSH6 hom Verified 0.895204330756471 0.185338935050922 no 920 0.155877134754423 538 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; also involved in interstrand cross-link repair; potentially phosphorylated by Cdc28p mismatch repair|meiotic mismatch repair guanine/thymine mispair binding|four-way junction DNA binding|ATPase activity|single base insertion or deletion binding|ATP binding MutSalpha complex|nucleus
YNL087W YNL087W TCB2 hom Verified 0.895099776364235 0.185366876753895 no 921 0.18873531094063 654 NA FT ENDOPLASMIC RETICULUM|PLASMA MEMBRANE ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains 3 calcium and lipid binding domains; mRNA is targeted to the bud biological_process lipid binding cellular bud|cortical endoplasmic reticulum
YDR528W YDR528W HLR1 hom Verified 0.894021220277056 0.185655268759098 no 922 0.15811019696076 520 NA FT CELL WALL ORG/BIOGENESIS Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A;
HLR1 has a paralog, LRE1, that arose from the whole genome duplication fungal-type cell wall organization molecular_function cytoplasm
YGL049C YGL049C TIF4632 hom Verified 0.893846390207138 0.185702042273708 no 923 0.160123355677149 554 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION RIBOSOME Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); TIF4632 has a paralog, TIF4631, that arose from the whole genome duplication translational initiation|stress granule assembly translation initiation factor binding|mRNA binding|translation initiation factor activity eukaryotic translation initiation factor 4F complex|cytoplasmic stress granule
YKR020W YKR020W VPS51 hom Verified 0.892754300389295 0.185994382156343 no 924 0.226257674212939 765 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL DIVISION|VACUOLAR TRANSPORT GOLGI APPARATUS Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; links the (VFT/GARP) complex to the SNARE Tlg1p vesicle organization|retrograde transport, endosome to Golgi|budding cell apical bud growth|regulation of cell size|protein targeting to vacuole protein binding Golgi apparatus|GARP complex
YLR419W_p YLR419W YLR419W hom Uncharacterized 0.891671461031762 0.18628452734539 no 925 0.181519560815309 582 NA FT MITOCHONDRION Putative helicase with limited sequence similarity to human Rb protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR419W is not an essential gene biological_process molecular_function mitochondrion|cytoplasm
YIR034C YIR034C LYS1 hom Verified 0.891625174889916 0.186296935894873 no 926 0.205476221813207 668 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS Saccharopine dehydrogenase (NAD+, L-lysine-forming), catalyzes the conversion of saccharopine to L-lysine, which is the final step in the lysine biosynthesis pathway; also has mRNA binding activity lysine biosynthetic process|lysine biosynthetic process via aminoadipic acid saccharopine dehydrogenase (NAD+, L-lysine-forming) activity|mRNA binding cytoplasm
YGL104C YGL104C VPS73 hom Verified 0.890042633490808 0.186721497125487 no 927 0.203986886173589 685 NA FT PROTEIN LOCALIZATION|VACUOLAR TRANSPORT MITOCHONDRION Mitochondrial protein; mutation affects vacuolar protein sorting; putative transporter; member of the sugar porter family transport|transmembrane transport|protein targeting to vacuole substrate-specific transmembrane transporter activity mitochondrion|integral to membrane
YER181C_d YER181C YER181C hom Dubious 0.888905600175363 0.18702690773985 no 928 0.179157596413581 636 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative data; extensively overlaps a Ty1 LTR; protein product is detected in highly purified mitochondria in high-throughput studies Unknown Unknown Unknown
YDL200C YDL200C MGT1 hom Verified 0.888891483377362 0.187030701495989 no 929 0.209081223426032 692 NA FT RESPONSE TO DNA DAMAGE NUCLEUS DNA repair methyltransferase (6-O-methylguanine-DNA methylase) involved in protection against DNA alkylation damage DNA dealkylation involved in DNA repair methylated-DNA-[protein]-cysteine S-methyltransferase activity nucleus
YPR130C_d YPR130C YPR130C hom Dubious 0.8884141824412 0.187158999629217 no 930 0.191799894409485 670 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPL053C YPL053C KTR6 hom Verified 0.887585692938212 0.187381826182969 no 931 0.186126316141897 673 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM Probable mannosylphosphate transferase; involved in the synthesis of core oligosaccharides in protein glycosylation pathway; member of the KRE2/MNT1 mannosyltransferase family; KTR6 has a paralog, KRE2, that arose from the whole genome duplication fungal-type cell wall organization|protein N-linked glycosylation mannosylphosphate transferase activity membrane
YLR264W YLR264W RPS28B hom Verified 0.886743037622698 0.187608630850363 no 932 0.182334976655431 621 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION|RNA LOCALIZATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S28, no bacterial homolog; RPS28B has a paralog, RPS28A, that arose from the whole genome duplication cytoplasmic translation|rRNA export from nucleus structural constituent of ribosome cytosolic small ribosomal subunit
YBR137W YBR137W YBR137W hom Verified 0.8861048464048 0.187780515861559 no 933 0.160803615397862 570 NA Protein of unknown function; localized to the cytoplasm; binds to Replication Protein A (RPA); also interacts with Sgt2p; YBR137W is not an essential gene biological_process molecular_function TRC complex|cytoplasm
YBR085W YBR085W AAC3 hom Verified 0.885377544480969 0.187976519735045 no 934 0.170615872113032 587 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Aac1p; has roles in maintenance of viability and in respiration; AAC3 has a paralog, PET9, that arose from the whole genome duplication heme biosynthetic process|heme transport|anaerobic respiration|transmembrane transport ATP:ADP antiporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YDL099W YDL099W BUG1 hom Verified 0.885362009654163 0.18798070766279 no 935 0.152399553042123 535 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT GOLGI APPARATUS Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes protein secretion|ER to Golgi vesicle-mediated transport molecular_function cis-Golgi network|cytoplasm
YPR001W YPR001W CIT3 hom Verified 0.884246773098452 0.188281507144496 no 936 0.207178529018964 686 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate propionate catabolic process, 2-methylcitrate cycle|propionate metabolic process|tricarboxylic acid cycle 2-methylcitrate synthase activity|citrate (Si)-synthase activity mitochondrion
YHR091C YHR091C MSR1 hom Verified 0.882901343204422 0.188644788913721 no 937 0.184250141397644 643 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial arginyl-tRNA synthetase; mutations in human ortholog are associated with pontocerebellar hypoplasia type 6 arginyl-tRNA aminoacylation|mitochondrial arginyl-tRNA aminoacylation|mitochondrial translation arginine-tRNA ligase activity mitochondrion
YBL062W_d YBL062W YBL062W hom Dubious 0.882783558950092 0.188676612593754 no 938 0.216736787183679 726 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR381W YLR381W CTF3 hom Verified 0.881594018169253 0.188998195549489 no 939 0.163412639337495 573 NA FT CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME KINETOCHORE Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p; may bind the kinetochore to spindle microtubules; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-I and fission yeast mis6 chromosome segregation|DNA replication initiation|establishment of mitotic sister chromatid cohesion molecular_function condensed nuclear chromosome kinetochore
YMR105C YMR105C PGM2 hom Verified 0.881401779278353 0.18905019748898 no 940 0.165920809228766 536 NA FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY Phosphoglucomutase; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase; protein abundance increases in response to DNA replication stress glucose 6-phosphate metabolic process|cellular calcium ion homeostasis|galactose catabolic process|cellular cation homeostasis|glucose 1-phosphate metabolic process|trehalose biosynthetic process|UDP-glucose metabolic process|glycogen biosynthetic process phosphoglucomutase activity cytoplasm
YGL212W YGL212W VAM7 hom Verified 0.881284277131564 0.189081986965372 no 941 0.203544756916034 684 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION Vacuolar SNARE protein; functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding; SNAP-25 homolog; protein abundance increases in response to DNA replication stress piecemeal microautophagy of nucleus|vacuole fusion, non-autophagic|vesicle fusion SNAP receptor activity|phosphatidylinositol-3-phosphate binding SNARE complex|fungal-type vacuole membrane
YNL231C YNL231C PDR16 hom Verified 0.881143886376547 0.189119973129048 no 942 0.20936582964758 718 NA FF|FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Phosphatidylinositol transfer protein (PITP); controlled by the multiple drug resistance regulator Pdr1p; localizes to lipid particles and microsomes; controls levels of various lipids, may regulate lipid synthesis; homologous to Pdr17p; protein abundance increases in response to DNA replication stress response to drug|sterol biosynthetic process|phospholipid biosynthetic process|phospholipid transport phosphatidylinositol transporter activity|phosphatidylcholine transporter activity cell periphery|lipid particle|plasma membrane|cytoplasm
YBR078W YBR078W ECM33 hom Verified 0.880815425353202 0.189208864677437 no 943 0.273606618166025 906 NA FF|FT CELL WALL ORG/BIOGENESIS MITOCHONDRION|PLASMA MEMBRANE GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p and Pst1p fungal-type cell wall organization molecular_function mitochondrion|fungal-type cell wall|plasma membrane
YEL051W YEL051W VMA8 hom Verified 0.880755334048531 0.189225129996467 no 944 0.215181600563795 713 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Subunit D of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis vacuolar acidification proton-transporting ATPase activity, rotational mechanism fungal-type vacuole membrane|vacuolar proton-transporting V-type ATPase, V1 domain|integral to membrane
YIL039W YIL039W TED1 hom Verified 0.880678823053509 0.189245840989771 no 945 0.22578582852971 784 NA FT VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) ER to Golgi vesicle-mediated transport molecular_function endoplasmic reticulum
YIL085C YIL085C KTR7 hom Verified 0.877955455788929 0.189983946247021 no 946 0.179780021208782 612 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM GOLGI APPARATUS Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR7 has a paralog, KTR5, that arose from the whole genome duplication fungal-type cell wall organization|protein N-linked glycosylation mannosyltransferase activity Golgi apparatus
YFL013W-A_d YFL013W-A YFL013W-A hom Dubious 0.876978128937338 0.19024925881004 no 947 0.208738723443109 718 NA Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps IES1/YFL013C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching Unknown Unknown Unknown
YGR007W YGR007W ECT1 hom Verified 0.876468573493268 0.190387676826896 no 948 0.196602912967501 648 NA FT LIPID METABOLISM NUCLEUS Ethanolamine-phosphate cytidylyltransferase, catalyzes the second step of phosphatidylethanolamine biosynthesis; involved in the maintenance of plasma membrane; similar to mammalian CTP: phosphocholine cytidylyl-transferases phosphatidylethanolamine biosynthetic process ethanolamine-phosphate cytidylyltransferase activity nucleus|cytoplasm
YGR254W YGR254W ENO1 hom Verified 0.875761913872408 0.190579739474866 no 949 0.175780072698938 588 NA FT MEMBRANE ORGANIZATION|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Enolase I, a phosphopyruvate hydratase; catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is repressed in response to glucose; protein abundance increases in response to DNA replication stress regulation of vacuole fusion, non-autophagic|gluconeogenesis|glycolysis phosphopyruvate hydratase activity mitochondrion|phosphopyruvate hydratase complex|plasma membrane|fungal-type vacuole|cytoplasm
YGR161W-C_p YGR161W-C YGR161W-C hom Uncharacterized 0.875599714369116 0.190623840370958 no 950 0.153295181510496 496 NA Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species biological_process molecular_function cellular_component
YEL047C YEL047C FRD1 hom Verified 0.874952394220481 0.190799904512525 no 951 0.187084461060476 655 NA FT OXIDATION-REDUCTION PROCESS MITOCHONDRION Soluble fumarate reductase; required with isoenzyme Osm1p for anaerobic growth; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to Arxula adeninovorans fumarate reductase; protein abundance increases in response to DNA replication stress; FRD1 has a paralog, OSM1, that arose from the whole genome duplication cellular response to anoxia fumarate reductase (NADH) activity cytosol|mitochondrion|ribosome|plasma membrane
YOR271C_p YOR271C FSF1 hom Uncharacterized 0.872839949622259 0.191375160591504 no 952 0.178940087771528 620 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis biological_process molecular_function mitochondrion|integral to membrane
YPR194C YPR194C OPT2 hom Verified 0.872480059008197 0.191473271039006 no 953 0.189768186263555 679 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION PLASMA MEMBRANE Oligopeptide transporter; member of the OPT family, with potential orthologs in S. pombe and C. albicans; also plays a role in formation of mature vacuoles oligopeptide transport|vacuole fusion, non-autophagic oligopeptide transporter activity integral to membrane|integral to plasma membrane
YDR006C YDR006C SOK1 hom Verified 0.87244276644922 0.191483439194476 no 954 0.176007495084606 580 NA FT SIGNALING NUCLEUS Protein whose overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13 cAMP-mediated signaling molecular_function nucleus
YBR093C YBR093C PHO5 hom Verified 0.87228576865968 0.191526249698123 no 955 0.179786110360436 646 NA FT RESPONSE TO NUTRIENT LEVELS Repressible acid phosphatase (1 of 3) that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2 cellular response to phosphate starvation|phosphate-containing compound metabolic process|regulation of cell size nucleoside-triphosphate diphosphatase activity|nucleoside-triphosphatase activity|acid phosphatase activity fungal-type cell wall|cell wall-bounded periplasmic space
YBR031W YBR031W RPL4A hom Verified 0.871516732704945 0.19173603681534 no 956 0.182394836481436 662 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L4A; N-terminally acetylated; homologous to mammalian ribosomal protein L4 and bacterial L4; RPL4A has a paralog, RPL4B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YGL217C_d YGL217C YGL217C hom Dubious 0.870562597488338 0.191996513096658 no 957 0.168794565439475 566 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF KIP3/YGL216W Unknown Unknown Unknown
YDR377W YDR377W ATP17 hom Verified 0.869641344435332 0.192248218028418 no 958 0.20895659692079 703 NA FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS MITOCHONDRION Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis ATP synthesis coupled proton transport hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism mitochondrion|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
YLR184W_d YLR184W YLR184W hom Dubious 0.869497700214976 0.192287482710494 no 959 0.177818181650475 646 NA Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YMR027W_p YMR027W YMR027W hom Uncharacterized 0.869094407765408 0.192397747608056 no 960 0.203781191688875 705 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR027W is not an essential gene biological_process molecular_function nucleus|cytoplasm
YFR015C YFR015C GSY1 hom Verified 0.868555105942305 0.192545259473701 no 961 0.155226666430703 516 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Glycogen synthase; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase; GSY1 has a paralog, GSY2, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress glycogen biosynthetic process glycogen (starch) synthase activity mitochondrion|cytoplasm
YBR299W YBR299W MAL32 hom Verified 0.86741343711761 0.192857761032669 no 962 0.197384295911691 692 NA FT CARBOHYDRATE METABOLISM Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose sucrose catabolic process|maltose catabolic process sucrose alpha-glucosidase activity|alpha-glucosidase activity|maltose alpha-glucosidase activity plasma membrane
YPR070W YPR070W MED1 hom Verified 0.867194148978863 0.192917820794598 no 963 0.22060868610711 761 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter molecular_function core mediator complex
YOL030W YOL030W GAS5 hom Verified 0.867023726346465 0.192964504908641 no 964 0.189873412122264 651 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM 1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall (1->3)-beta-D-glucan metabolic process 1,3-beta-glucanosyltransferase activity fungal-type cell wall|integral to membrane
YJL067W_d YJL067W YJL067W hom Dubious 0.866503245744471 0.193107123605436 no 965 0.172835853257965 595 NA Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOR050C_d YOR050C YOR050C hom Dubious 0.866111057868389 0.193214630870283 no 966 0.167482711547068 566 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable Unknown Unknown Unknown
YCL057C-A YCL057C-A MOS1 hom Verified 0.864788991644318 0.193577307165914 no 967 0.176395503062175 627 NA FT MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial protein essential for proper inner membrane organization; conserved component of the mitochondrial inner membrane organizing system (MICOS, MINOS, or MitOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture; ortholog of human MINOS1 cristae formation molecular_function mitochondrion|mitochondrial crista junction|integral to mitochondrial inner membrane
YCR023C YCR023C YCR023C hom Verified 0.861914023113403 0.194367415820821 no 968 0.186178683558574 653 NA Vacuolar membrane protein of unknown function; member of the multidrug resistance family; YCR023C is not an essential gene biological_process molecular_function fungal-type vacuole membrane|integral to membrane
YMR150C YMR150C IMP1 hom Verified 0.860596652966641 0.194730115000542 no 969 0.17886627741209 542 NA FT PROTEIN LOCALIZATION|PROTEOLYSIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p protein processing involved in protein targeting to mitochondrion endopeptidase activity mitochondrion|mitochondrial inner membrane peptidase complex
YER124C YER124C DSE1 hom Verified 0.860590755765375 0.19473173954685 no 970 0.205499710806396 724 NA FT CELL CYCLE|SIGNALING|CELL WALL ORG/BIOGENESIS|CELL DIVISION SITE OF POLARIZED GROWTH Daughter cell-specific protein, may regulate cross-talk between the mating and filamentation pathways; deletion affects cell separation after division and sensitivity to alpha-factor and drugs affecting the cell wall; relocalizes from bud neck to cytoplasm upon DNA replication stress cytokinesis, completion of separation|regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion|invasive growth in response to glucose limitation molecular_function cellular bud neck
YOR246C YOR246C ENV9 hom Verified 0.860533040540291 0.194747639228412 no 971 0.205923642778115 738 NA FF|FT OXIDATION-REDUCTION PROCESS|VACUOLAR PROTEIN PROCESSING Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts vacuole organization|vacuolar protein processing oxidoreductase activity lipid particle
YMR015C YMR015C ERG5 hom Verified 0.859834125948604 0.194940242427916 no 972 0.246138313743426 879 NA FF|FT LIPID METABOLISM|OXIDATION-REDUCTION PROCESS ENDOPLASMIC RETICULUM C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs ergosterol biosynthetic process C-22 sterol desaturase activity endoplasmic reticulum
YJR049C YJR049C UTR1 hom Verified 0.85942658645756 0.195052603453388 no 973 0.222077688283714 758 NA FF|FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS|COFACTOR METABOLISM NUCLEUS ATP-NADH kinase; phosphorylates both NAD and NADH; active as a hexamer; enhances the activity of ferric reductase (Fre1p); UTR1 has a paralog, YEF1, that arose from the whole genome duplication cellular iron ion homeostasis|NADP biosynthetic process NAD+ kinase activity|NADH kinase activity nucleus|cytoplasm
YKR072C YKR072C SIS2 hom Verified 0.859409436899348 0.19505733255013 no 974 0.245790790565144 854 NA FF|FT CELL CYCLE|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM NUCLEUS Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis regulation of mitotic cell cycle|response to salt stress|coenzyme A biosynthetic process phosphopantothenoylcysteine decarboxylase activity|protein phosphatase inhibitor activity phosphopantothenoylcysteine decarboxylase complex|nucleus|cytoplasm
YNL249C YNL249C MPA43 hom Verified 0.858158164288384 0.195402566755465 no 975 0.205440106348315 696 NA FT CARBOHYDRATE METABOLISM MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YCL040W YCL040W GLK1 hom Verified 0.857516251498725 0.195579818601008 no 976 0.200226399931878 661 NA FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Glucokinase; catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources; GLK1 has a paralog, EMI2, that arose from the whole genome duplication glucose import|mannose metabolic process|glycolysis|glucose metabolic process glucokinase activity cytosol|plasma membrane
YJR054W YJR054W KCH1 hom Verified 0.857188401293632 0.195670385769808 no 977 0.177807850666174 580 NA Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate biological_process molecular_function integral to membrane|fungal-type vacuole
YDL230W YDL230W PTP1 hom Verified 0.855362775444282 0.196175172299541 no 978 0.171774514105302 557 NA FT MITOCHONDRION Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria; proposed to be a negative regulator of filamentation pseudohyphal growth|invasive growth in response to glucose limitation|protein dephosphorylation protein tyrosine phosphatase activity mitochondrion|cytoplasm
YGL235W_p YGL235W YGL235W hom Uncharacterized 0.854365879329922 0.196451147639245 no 979 0.176178695679338 605 NA Putative protein of unknown function; potential Cdc28p substrate; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2 biological_process molecular_function cellular_component
YLL021W YLL021W SPA2 hom Verified 0.853660336321012 0.196646608468749 no 980 0.203065114127337 705 NA FT CELL CYCLE|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate regulation of initiation of mating projection growth|regulation of termination of mating projection growth|pseudohyphal growth|invasive filamentous growth|mating projection assembly cytoskeletal regulatory protein binding incipient cellular bud site|cellular bud neck|mating projection tip|cellular bud tip
YKL217W YKL217W JEN1 hom Verified 0.851967404877923 0.197116091695511 no 981 0.189407688884296 661 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION|PLASMA MEMBRANE Monocarboxylate/proton symporter of the plasma membrane; transport activity is dependent on the pH gradient across the membrane; mediates high-affinity uptake of carbon sources lactate, pyuvate, and acetate, and also of the micronutrient selenite, whose structure mimics that of monocarboxylates; expression and localization are tightly regulated, with transcription repression, mRNA degradation, and protein endocytosis and degradation all occurring in the presence of glucose plasma membrane lactate transport|plasma membrane selenite transport|plasma membrane pyruvate transport selenite:hydrogen symporter activity|secondary active monocarboxylate transmembrane transporter activity mitochondrion|integral to membrane|plasma membrane
YBR221C YBR221C PDB1 hom Verified 0.851145460784732 0.197344277370038 no 982 0.175115372397059 590 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION E1 beta subunit of the pyruvate dehydrogenase (PDH) complex, which is an evolutionarily-conserved multi-protein complex found in mitochondria acetyl-CoA biosynthetic process from pyruvate pyruvate dehydrogenase (acetyl-transferring) activity mitochondrial nucleoid|mitochondrion|mitochondrial pyruvate dehydrogenase complex
YPR135W YPR135W CTF4 hom Verified 0.850804598920308 0.197438953273857 no 983 0.255324419457214 868 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Chromatin-associated protein, required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion DNA repair|replicative cell aging|double-strand break repair via break-induced replication|DNA replication initiation|DNA-dependent DNA replication|mitotic sister chromatid cohesion chromatin binding|DNA binding nuclear chromosome|replication fork protection complex|nuclear replication fork|nucleus
YLR283W_p YLR283W YLR283W hom Uncharacterized 0.850629923869224 0.197487480690698 no 984 0.17938595653623 614 NA FT MITOCHONDRION Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR283W is not an essential gene biological_process molecular_function mitochondrion
YPR150W_d YPR150W YPR150W hom Dubious 0.850492913339804 0.197525549370177 no 985 0.170028792414369 592 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SUE1/YPR151C Unknown Unknown Unknown
YDR204W YDR204W COQ4 hom Verified 0.849138200839529 0.197902198000916 no 986 0.184726977198233 649 NA FT KETONE METABOLISM|COFACTOR METABOLISM MITOCHONDRION Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex ubiquinone biosynthetic process molecular_function mitochondrial inner membrane
YHR106W YHR106W TRR2 hom Verified 0.849050695853984 0.197926541785044 no 987 0.161802643643901 540 NA FT OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS MITOCHONDRION Mitochondrial thioredoxin reductase; involved in protection against oxidative stress, required with Glr1p to maintain the redox state of Trx3p; contains active-site motif (CAVC) present in prokaryotic orthologs; binds NADPH and FAD; TRR2 has a paralog, TRR1, that arose from the whole genome duplication cellular response to oxidative stress|cell redox homeostasis thioredoxin-disulfide reductase activity mitochondrion
YOL049W YOL049W GSH2 hom Verified 0.84847585779513 0.198086506022965 no 988 0.194651205736631 684 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Glutathione synthetase, catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock glutathione biosynthetic process glutathione synthase activity intracellular
YLR363C YLR363C NMD4 hom Verified 0.847871760368205 0.198254696569981 no 989 0.196975059929832 705 NA Protein that may be involved in nonsense-mediated mRNA decay; interacts with Nam7p, relocalizes from nucleus to cytoplasmic foci upon DNA replication stress nuclear-transcribed mRNA catabolic process, nonsense-mediated decay molecular_function cytoplasm
YBR034C YBR034C HMT1 hom Verified 0.847037100856172 0.198487221123109 no 990 0.217419071642361 731 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|RNA LOCALIZATION NUCLEUS Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs, including Npl3p and Hrp1p, affecting their activity and nuclear export; methylates U1 snRNP protein Snp1p and ribosomal protein Rps2p; interacts genetically with genes encoding components of Rpd3(L) and this interaction is important for Rpd3 recruitment to the subtelomeric region. mRNA export from nucleus|negative regulation of DNA-dependent transcription, termination|positive regulation of transcription elongation from RNA polymerase II promoter|peptidyl-arginine methylation protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity nucleus
YFR043C YFR043C IRC6 hom Verified 0.846647946478808 0.198595690344284 no 991 0.200835501045569 685 NA Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci biological_process molecular_function cellular_component
YNL024C_p YNL024C YNL024C hom Uncharacterized 0.846453306667466 0.198649955819755 no 992 0.200154068318374 688 NA Putative methyltransferase; has seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; despite similarity to methyltransferases, null mutant does not display alterations in lysine methylation pattern biological_process S-adenosylmethionine-dependent methyltransferase activity cytoplasm
YGR087C YGR087C PDC6 hom Verified 0.846387571824687 0.198668284678589 no 993 0.196878860283706 670 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation L-phenylalanine catabolic process|ethanol metabolic process|tryptophan catabolic process|aromatic amino acid family catabolic process to alcohol via Ehrlich pathway pyruvate decarboxylase activity cytoplasm
YBR280C YBR280C SAF1 hom Verified 0.845307893905149 0.19896947739459 no 994 0.199469656734149 675 NA FT PROTEOLYSIS UBIQUITIN LIGASE COMPLEX F-Box protein involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence; interacts with Skp1 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity SCF ubiquitin ligase complex
YGR236C YGR236C SPG1 hom Verified 0.842645543831038 0.199713355756246 no 995 0.196614047540962 676 NA FT MITOCHONDRION Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YNL325C YNL325C FIG4 hom Verified 0.841105947416358 0.200144291781228 no 996 0.214831365529754 713 NA FT LIPID METABOLISM Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase; required for efficient mating and response to osmotic shock; physically associates with and regulated by Vac14p; contains a SAC1-like domain phosphatidylinositol dephosphorylation phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity fungal-type vacuole membrane|PAS complex|extrinsic to membrane
YLR091W YLR091W GEP5 hom Verified 0.840505978889128 0.200312375356537 no 997 0.226276455381817 766 NA FT MITOCHONDRION ORGANIZATION MITOCHONDRION Protein of unknown function, required for mitochondrial genome maintenance; detected in highly purified mitochondria in high-throughput studies; null mutant has decreased levels of cardiolipin and phosphatidylethanolamine mitochondrial genome maintenance molecular_function mitochondrion
YOL164W-A_p YOL164W-A YOL164W-A hom Uncharacterized 0.840298006758837 0.200370659367033 no 998 0.175163244466586 616 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YDL210W YDL210W UGA4 hom Verified 0.840226420252388 0.200390723780503 no 999 0.168947016160394 561 NA Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane gamma-aminobutyric acid transport|putrescine transport|transmembrane transport putrescine transmembrane transporter activity|gamma-aminobutyric acid:hydrogen symporter activity fungal-type vacuole membrane|integral to membrane
YPR002W YPR002W PDH1 hom Verified 0.839582040540828 0.200571386175788 no 1000 0.209182511706421 740 NA FT KETONE METABOLISM MITOCHONDRION Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate propionate metabolic process|propionate catabolic process, 2-methylcitrate cycle 2-methylcitrate dehydratase activity mitochondrial outer membrane|mitochondrion|cytoplasm
YFL027C YFL027C GYP8 hom Verified 0.838551921668819 0.200860399918206 no 1001 0.18727222079066 644 NA FT VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport vesicle-mediated transport Rab GTPase activator activity intracellular
YLL026W YLL026W HSP104 hom Verified 0.836785818522735 0.201356485098347 no 1002 0.204450615249833 698 NA FT PROTEIN LOCALIZATION|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS NUCLEUS Disaggregase; heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress trehalose metabolism in response to heat stress|protein folding in endoplasmic reticulum|protein unfolding|chaperone cofactor-dependent protein refolding|inheritance of oxidatively modified proteins involved in replicative cell aging|cellular heat acclimation ADP binding|unfolded protein binding|ATPase activity, coupled|chaperone binding|ATP binding TRC complex|nucleus|cytoplasm
YER027C YER027C GAL83 hom Verified 0.836323786954314 0.201486387409304 no 1003 0.199978941491438 649 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|SIGNALING|PROTEIN PHOSPHORYLATION ENDOMEMBRANE SYSTEM|NUCLEUS One of three possible beta-subunits of the Snf1 kinase complex, allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source; contains glycogen-binding domain signal transduction|cell adhesion|protein phosphorylation|invasive growth in response to glucose limitation|regulation of protein complex assembly AMP-activated protein kinase activity AMP-activated protein kinase complex|nucleus|nuclear envelope lumen|cytoplasm
YPR038W_d YPR038W IRC16 hom Dubious 0.835243371156801 0.201790347253234 no 1004 0.192762136792008 681 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene YPR037C; null mutant displays increased levels of spontaneous Rad52p foci Unknown Unknown Unknown
YPR185W YPR185W ATG13 hom Verified 0.834909452290404 0.201884346165181 no 1005 0.188705619680179 655 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Regulatory subunit of the Atg1p signaling complex; stimulates Atg1p kinase activity; required for vesicle formation during autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; involved in Atg9p, Atg23p, and Atg27p cycling piecemeal microautophagy of nucleus|mitochondrion degradation|macroautophagy|activation of protein kinase activity|CVT pathway protein kinase regulator activity Atg1p signaling complex|extrinsic to membrane
YPL212C YPL212C PUS1 hom Verified 0.834469047795405 0.202008361100404 no 1006 0.190514445250683 654 NA FT RNA PROCESSING NUCLEUS tRNA:pseudouridine synthase, introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA; nuclear protein that appears to be involved in tRNA export; also acts on U2 snRNA snRNA pseudouridine synthesis|tRNA pseudouridine synthesis pseudouridine synthase activity nucleus
YML012W YML012W ERV25 hom Verified 0.833426692518205 0.202302062924563 no 1007 0.187991664275267 688 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Protein that forms a heterotrimeric complex with Erp1, Erp2p, and Emp24, member of the p24 family involved in endoplasmic reticulum to Golgi transport ER to Golgi vesicle-mediated transport molecular_function ER to Golgi transport vesicle
YJL210W YJL210W PEX2 hom Verified 0.833244282765238 0.202353486307775 no 1008 0.192200762183777 638 NA FT PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION RING-finger peroxin and E3 ubiquitin ligase, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import protein import into peroxisome matrix ubiquitin-protein ligase activity|protein binding peroxisomal membrane
YGR250C YGR250C YGR250C hom Verified 0.833171941511373 0.202373882294391 no 1009 0.207523331744745 697 NA Putative RNA binding protein; localizes to stress granules induced by glucose deprivation; interacts with Rbg1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress biological_process RNA binding cytoplasmic stress granule|cytoplasm
YHL028W YHL028W WSC4 hom Verified 0.833054228131697 0.202407073184517 no 1010 0.185128756299616 612 NA FT PROTEIN LOCALIZATION|CELL WALL ORG/BIOGENESIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM ER membrane protein involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3 response to heat|SRP-dependent cotranslational protein targeting to membrane, translocation|protein targeting to ER|response to stress transmembrane signaling receptor activity endoplasmic reticulum membrane
YBR259W YBR259W YBR259W hom Verified 0.832410436183375 0.202588656666772 no 1011 0.204498335112213 661 NA Protein of unknown function; YBR259W is not an essential gene; forms cytoplasmic foci upon DNA replication stress biological_process molecular_function cellular_component
YBR125C YBR125C PTC4 hom Verified 0.831662286748928 0.202799796777062 no 1012 0.174922576921987 591 NA Cytoplasmic type 2C protein phosphatase (PP2C); identified as a high-copy number suppressor of cnb1 mpk1 synthetic lethality; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity protein dephosphorylation protein serine/threonine phosphatase activity cytoplasm
YIL101C YIL101C XBP1 hom Verified 0.831661060084007 0.202800143070054 no 1013 0.203315993054155 710 NA FT NUCLEUS Transcriptional repressor; binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4p/Mbp1p family; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress response to stress sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nucleus
YBR178W_d YBR178W YBR178W hom Dubious 0.831137259007913 0.202948046737838 no 1014 0.210824362940641 699 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR177C Unknown Unknown Unknown
YOR192C YOR192C THI72 hom Verified 0.831077500356804 0.20296492464836 no 1015 0.218331959181841 746 NA Transporter of thiamine or related compound; shares sequence similarity with Thi7p thiamine transport transporter activity integral to membrane|membrane
YDR129C YDR129C SAC6 hom Verified 0.830774839735992 0.203050419352147 no 1016 0.323270825151688 1084 NA FF|FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton; relocalizes from plasma membrane to cytoplasm upon DNA replication stress bipolar cellular bud site selection|actin filament organization|endocytosis|response to osmotic stress actin filament binding|protein binding, bridging actin filament bundle|mating projection tip|actin cortical patch
YBR244W YBR244W GPX2 hom Verified 0.829370568693849 0.203447375061062 no 1017 0.170541046585961 614 NA FT OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS NUCLEUS|MITOCHONDRION Phospholipid hydroperoxide glutathione peroxidase; protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; induced by glucose starvation; protein abundance increases in response to DNA replication stress cellular response to oxidative stress phospholipid-hydroperoxide glutathione peroxidase activity|glutathione peroxidase activity extrinsic to mitochondrial inner membrane|extrinsic to mitochondrial outer membrane|nucleus|cytoplasm
YPR066W YPR066W UBA3 hom Verified 0.829036804711198 0.203541790649638 no 1018 0.214246601150153 727 NA Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern protein neddylation NEDD8 activating enzyme activity cytoplasm
YPL189W YPL189W GUP2 hom Verified 0.828875168354374 0.203587523943053 no 1019 0.150252798180481 490 NA Probable membrane protein with a possible role in proton symport of glycerol; member of the MBOAT family of putative membrane-bound O-acyltransferases; Gup1p homolog glycerol transport O-acyltransferase activity integral to membrane|membrane
YDL233W_p YDL233W MFG1 hom Uncharacterized 0.825644893629706 0.204502780317608 no 1020 0.193688229941675 644 NA FT NUCLEUS Regulator of filamentous growth; interacts with FLO11 promoter and regulates FLO11 expression; binds to transcription factors Flo8p and Mss11p; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YDL233W is not an essential gene biological_process molecular_function nucleus|cytoplasm
YPR037C YPR037C ERV2 hom Verified 0.825266057538699 0.204610278799742 no 1021 0.196243222541007 641 NA FT OXIDATION-REDUCTION PROCESS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen, involved in disulfide bond formation within the ER protein thiol-disulfide exchange thiol oxidase activity integral to endoplasmic reticulum membrane
YOR234C YOR234C RPL33B hom Verified 0.824701743726219 0.20477047074375 no 1022 0.206785602956467 673 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L33B; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33B has a paralog, RPL33A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YML097C YML097C VPS9 hom Verified 0.823332673415226 0.205159419049648 no 1023 0.201892641580241 707 NA FF|FT PROTEIN LOCALIZATION|VACUOLAR TRANSPORT A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin vacuole inheritance|protein targeting to vacuole ubiquitin binding|guanyl-nucleotide exchange factor activity cytosol
YJL027C_p YJL027C YJL027C hom Uncharacterized 0.823316764101459 0.20516394141145 no 1024 0.190664858380651 664 NA Putative protein of unknown function biological_process molecular_function cellular_component
YER080W YER080W AIM9 hom Verified 0.822242196238447 0.205469533841622 no 1025 0.214494697935739 717 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss biological_process molecular_function mitochondrion
YER087C-A_d YER087C-A YER087C-A hom Dubious 0.820931706510487 0.205842584815194 no 1026 0.193629549659223 639 NA Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; overlaps the uncharacterized gene YER087W, a putative tRNA synthetase Unknown Unknown Unknown
YJL079C YJL079C PRY1 hom Verified 0.820078195525913 0.206085765732439 no 1027 0.166829270852819 604 NA FT ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY2; may be involved in detoxification of hydrophobic compounds; PRY1 has a paralog, PRY2, that arose from the whole genome duplication biological_process molecular_function nuclear envelope|extracellular region|endoplasmic reticulum|fungal-type vacuole
YKL062W YKL062W MSN4 hom Verified 0.819243314868553 0.206323803267072 no 1028 0.202483897634486 678 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS|RESPONSE TO OXIDATIVE STRESS NUCLEUS Transcriptional activator; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression; MSN4 has a paralog, MSN2, that arose from the whole genome duplication positive regulation of transcription from RNA polymerase II promoter in response to heat stress|positive regulation of transcription from RNA polymerase II promoter in response to a hypotonic environment|positive regulation of transcription from RNA polymerase II promoter in response to alkalinity|positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation|positive regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation|positive regulation of transcription from RNA polymerase II promoter in response to acidity|chromatin remodeling|regulation of replicative cell aging by regulation of transcription from RNA polymerase II promoter in response to caloric restriction|positive regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide|positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance|positive regulation of transcription from RNA polymerase II promoter in response to increased salt|cellular response to acidity|positive regulation of transcription from RNA polymerase II promoter in response to freezing|positive regulation of transcription from RNA polymerase II promoter in response to ethanol|replicative cell aging|age-dependent response to oxidative stress involved in chronological cell aging|positive regulation of transcription from RNA polymerase II promoter in response to hydrostatic pressure|positive regulation of transcription from RNA polymerase II promoter in response to nitrosative stress|positive regulation of transcription from RNA polymerase II promoter in response to cold|positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding cytosol|nucleus
YDR202C YDR202C RAV2 hom Verified 0.819050131242837 0.20637890614548 no 1029 0.232471515040607 800 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS Subunit of RAVE (Rav1p, Rav2p, Skp1p), a complex that associates with the V1 domain of the vacuolar membrane (H+)-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme vacuolar acidification|regulation of protein complex assembly molecular_function RAVE complex
YMR175W-A_p YMR175W-A YMR175W-A hom Uncharacterized 0.81824481662604 0.206608704600899 no 1030 0.190135284111002 626 NA Putative protein of unknown function biological_process molecular_function cellular_component
YNR004W_p YNR004W SWM2 hom Uncharacterized 0.818019576062673 0.206673004645335 no 1031 0.1975684310377 690 NA FT NUCLEUS Putative protein of unknown function; haploid disruptant exhibits cold-sensitive growth and elongated buds biological_process molecular_function nucleolus
YBR062C_p YBR062C YBR062C hom Uncharacterized 0.816922540183538 0.206986347869024 no 1032 0.188304413082435 623 NA Protein of unknown function that interacts with Msb2p; may play a role in activation of the filamentous growth pathway. biological_process molecular_function cellular_component
YML072C YML072C TCB3 hom Verified 0.8161858592323 0.207196921624741 no 1033 0.215025877724444 742 NA FT ENDOPLASMIC RETICULUM|MITOCHONDRION|PLASMA MEMBRANE Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact biological_process lipid binding mitochondrion|cortical endoplasmic reticulum|cellular bud
YDR500C YDR500C RPL37B hom Verified 0.814821920881562 0.207587125665388 no 1034 0.185978684087771 634 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L37B; protein abundance increases in response to DNA replication stress; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37B has a paralog, RPL37A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YLR285W YLR285W NNT1 hom Verified 0.814368946156707 0.207716811508283 no 1035 0.188859696273093 645 NA FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|GENE SILENCING S-adenosylmethionine-dependent methyltransferase; has a role in rDNA silencing and in lifespan determination chromatin silencing at rDNA|nicotinamide metabolic process S-adenosylmethionine-dependent methyltransferase activity|nicotinamide N-methyltransferase activity cytoplasm
YDR090C_p YDR090C YDR090C hom Uncharacterized 0.813918789866911 0.207845737841146 no 1036 0.229036985694725 796 NA FT PLASMA MEMBRANE Putative protein of unknown function biological_process molecular_function integral to membrane
YGR228W_d YGR228W YGR228W hom Dubious 0.813694599415658 0.207909964393765 no 1037 0.235140639169404 819 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SMI1/YGR229C Unknown Unknown Unknown
YLR174W YLR174W IDP2 hom Verified 0.812320745081938 0.208303804952255 no 1038 0.181721426993841 615 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM Cytosolic NADP-specific isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose; IDP2 has a paralog, IDP3, that arose from the whole genome duplication glutamate biosynthetic process|isocitrate metabolic process isocitrate dehydrogenase (NADP+) activity cytosol
YBR148W YBR148W YSW1 hom Verified 0.812299998684173 0.208309755659198 no 1039 0.18018430343156 598 NA FT MEMBRANE ORGANIZATION Protein required for normal prospore membrane formation; interacts with Gip1p, which is the meiosis-specific regulatory subunit of the Glc7p protein phosphatase; expressed specifically in spores and localizes to the prospore membrane ascospore-type prospore membrane assembly molecular_function prospore membrane
YOR307C YOR307C SLY41 hom Verified 0.811641119512951 0.208498794694967 no 1040 0.219691903496992 711 NA FT VESICLE-MEDIATED TRANSPORT ENDOPLASMIC RETICULUM Protein involved in ER-to-Golgi transport ER to Golgi vesicle-mediated transport molecular_function integral to membrane|endoplasmic reticulum
YMR184W YMR184W ADD37 hom Verified 0.811146671777601 0.208640723121203 no 1041 0.207229387502077 667 NA FT PROTEOLYSIS Protein of unknown function; involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene; protein abundance increases in response to DNA replication stress ER-associated protein catabolic process molecular_function cytoplasm
YCL038C YCL038C ATG22 hom Verified 0.807869804180393 0.209582767856473 no 1042 0.200366972647343 689 NA FT PROTEIN LOCALIZATION|VACUOLAR TRANSPORT Vacuolar integral membrane protein required for efflux of amino acids during autophagic body breakdown in the vacuole; null mutation causes a gradual loss of viability during starvation amino acid export from vacuole molecular_function integral to fungal-type vacuolar membrane|integral to membrane
YML066C YML066C SMA2 hom Verified 0.807837326108836 0.209592117263443 no 1043 0.18104134447668 599 NA FT MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS ENDOPLASMIC RETICULUM Meiosis-specific prospore membrane protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation ascospore wall assembly|spore membrane bending pathway molecular_function integral to membrane|prospore membrane|cytoplasm
YBR162W-A YBR162W-A YSY6 hom Verified 0.807230101884208 0.209766963026746 no 1044 0.190063916981538 638 NA FT PROTEIN LOCALIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein whose expression suppresses a secretory pathway mutation in E. coli; has similarity to the mammalian RAMP4 protein involved in secretion protein secretion molecular_function endoplasmic reticulum
YNR067C YNR067C DSE4 hom Verified 0.806168650525285 0.210072806047346 no 1045 0.174781088455354 600 NA FT CELL WALL ORG/BIOGENESIS|CELL DIVISION Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother cytokinesis, completion of separation glucan endo-1,3-beta-D-glucosidase activity fungal-type cell wall|extracellular region|cell septum
YDL222C YDL222C FMP45 hom Verified 0.805155568222618 0.210364956372497 no 1046 0.176734555436238 577 NA FT CELL WALL ORG/BIOGENESIS MITOCHONDRION|PLASMA MEMBRANE Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C fungal-type cell wall organization|ascospore formation molecular_function cell cortex|mitochondrion|integral to membrane|plasma membrane
YHR047C YHR047C AAP1 hom Verified 0.804399915293803 0.210583025046926 no 1047 0.190289714594873 643 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEOLYSIS|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Arginine/alanine amino peptidase; overproduction stimulates glycogen accumulation; AAP1 has a paralog, APE2, that arose from the whole genome duplication glycogen metabolic process|proteolysis aminopeptidase activity nucleus|cytoplasm
YLR290C_p YLR290C YLR290C hom Uncharacterized 0.803191043851204 0.210932160641559 no 1048 0.177675739800209 580 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR290C is not an essential gene biological_process molecular_function mitochondrion
YNL324W_d YNL324W YNL324W hom Dubious 0.79869909565219 0.212232455649622 no 1049 0.239541322588032 796 NA Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YER122C YER122C GLO3 hom Verified 0.797844038350728 0.212480500900899 no 1050 0.216254524246165 727 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|NUCLEOTIDE METABOLISM ENDOMEMBRANE SYSTEM|GOLGI APPARATUS ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Gcs1p retrograde vesicle-mediated transport, Golgi to ER|COPI coating of Golgi vesicle|ER to Golgi vesicle-mediated transport ARF GTPase activator activity COPI-coated vesicle|endoplasmic reticulum-Golgi intermediate compartment|COPI vesicle coat
YML111W YML111W BUL2 hom Verified 0.797797327333741 0.212494056268372 no 1051 0.199299448251244 691 NA FT UBIQUITIN LIGASE COMPLEX Component of the Rsp5p E3-ubiquitin ligase complex; involved in intracellular amino acid permease sorting, functions in heat shock element mediated gene expression, essential for growth in stress conditions; BUL2 has a paralog, BUL1, that arose from the whole genome duplication protein polyubiquitination|protein monoubiquitination ubiquitin-ubiquitin ligase activity ubiquitin ligase complex|cytoplasm
YGL160W YGL160W AIM14 hom Verified 0.797664844701513 0.212532504995202 no 1052 0.215528120146939 723 NA FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY NADPH oxidase localized to the perinuclear ER; produces superoxide from NADPH; overexpression causes MCA1 dependent apoptosis; likely involved in superoxide-mediated regulation of the actin cytoskeleton; member of a conserved superfamily of NADPH oxidases (NOX enzymes); has similarity to iron/copper reductases (FRE1-8), particularly Fre8p biological_process oxidoreductase activity, oxidizing metal ions integral to membrane|ribosome
YGR234W YGR234W YHB1 hom Verified 0.797000729974744 0.212725303685492 no 1053 0.187465420200373 657 NA FT OXIDATION-REDUCTION PROCESS MITOCHONDRION Nitric oxide oxidoreductase; flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress response to stress nitric oxide reductase activity cytosol|mitochondrion|mitochondrial matrix|cytoplasm
YKR031C YKR031C SPO14 hom Verified 0.795635085096181 0.213122083843045 no 1054 0.208274267498841 719 NA FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|LIPID METABOLISM NUCLEUS Phospholipase D; catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions phospholipid metabolic process|exocytosis|cell morphogenesis involved in conjugation with cellular fusion|ascospore-type prospore assembly phospholipase D activity|phosphatidylinositol-3-phosphate binding endosome|nucleus|prospore membrane
YNL264C YNL264C PDR17 hom Verified 0.793496815873399 0.213744211854716 no 1055 0.217286624353259 745 NA FT LIPID METABOLISM Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition Golgi to plasma membrane protein transport|phosphatidylserine metabolic process|response to drug|sterol biosynthetic process|Unknown|phospholipid transport|phospholipid biosynthetic process phosphatidylinositol transporter activity|phosphatidylcholine transporter activity endosome|cell periphery|cytosol|cytoplasm
YMR016C YMR016C SOK2 hom Verified 0.793403135297529 0.213771492320342 no 1056 0.167000917563951 565 NA FT NUCLEUS Nuclear protein that negatively regulates pseudohyphal differentiation; plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; SOK2 has a paralog, PHD1, that arose from the whole genome duplication pseudohyphal growth sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nucleus
YFL048C YFL048C EMP47 hom Verified 0.791989744277653 0.214183328104482 no 1057 0.210199803094069 733 NA FT VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport ER to Golgi vesicle-mediated transport glycoprotein binding fungal-type vacuole membrane|integral to endoplasmic reticulum membrane|integral to Golgi membrane|ER to Golgi transport vesicle
YDR423C YDR423C CAD1 hom Verified 0.791085167173354 0.214447147095677 no 1058 0.222619295224653 741 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS AP-1-like basic leucine zipper (bZIP) transcriptional activator; involved in stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins; binds consensus sequence TTACTAA; CAD1 has a paralog, YAP1, that arose from the whole genome duplication cellular response to cadmium ion|positive regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus|cytoplasm
YPL113C_p YPL113C YPL113C hom Uncharacterized 0.789551742908104 0.214894800103099 no 1059 0.184364516396018 653 NA FT OXIDATION-REDUCTION PROCESS Glyoxylate reductase; acts on glyoxylate and hydroxypyruvate substrates; YPL113C is not an essential gene metabolic process oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor cellular_component
YGR042W YGR042W YGR042W hom Verified 0.788660752893741 0.215155156210891 no 1060 0.188826307419402 669 NA FT NUCLEUS Protein of unknown function; involved in maintenance of proper telomere length; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; forms nuclear foci upon DNA replication stress biological_process molecular_function nucleus|cytoplasm
YDL236W YDL236W PHO13 hom Verified 0.787563568527435 0.215476015786772 no 1061 0.22556558646648 787 NA FT NUCLEUS Alkaline phosphatase specific for p-nitrophenyl phosphate; also has protein phosphatase activity protein dephosphorylation 4-nitrophenylphosphatase activity|phosphoprotein phosphatase activity|alkaline phosphatase activity nucleus|cytoplasm
YNL069C YNL069C RPL16B hom Verified 0.787282218851962 0.215558338113142 no 1062 0.241115373555069 822 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L16B; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16B has a paralog, RPL16A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YMR167W YMR167W MLH1 hom Verified 0.786855551555358 0.215683214868469 no 1063 0.188956410882248 647 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION|CHROMOSOME Protein required for mismatch repair in mitosis and meiosis as well as crossing over during meiosis; forms a complex with Pms1p and Msh2p-Msh3p during mismatch repair; human homolog is associated with hereditary non-polyposis colon cancer mismatch repair|meiotic mismatch repair|reciprocal meiotic recombination|meiotic heteroduplex formation double-stranded DNA binding|DNA insertion or deletion binding|loop DNA binding|single-stranded DNA binding|dinucleotide insertion or deletion binding|ATPase activity|ATP binding mitochondrion|nucleus|MutLalpha complex|MutLbeta complex|cytoplasm
YMR285C YMR285C NGL2 hom Verified 0.786468832486265 0.215796435824434 no 1064 0.190062865923197 637 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p; NGL2 has a paralog, NGL3, that arose from the whole genome duplication rRNA processing endoribonuclease activity intracellular
YHR154W YHR154W RTT107 hom Verified 0.786453877947498 0.215800814803405 no 1065 0.244720347511885 836 NA FT RESPONSE TO DNA DAMAGE NUCLEUS UBIQUITIN LIGASE COMPLEX Protein implicated in Mms22-dependent DNA repair during S phase; involved in recruiting the SMC5/6 complex to double-strand breaks; DNA damage induces phosphorylation by Mec1p at one or more SQ/TQ motifs; interacts with Mms22p and Slx4p; has four BRCT domains; has a role in regulation of Ty1 transposition; relative distribution to nuclear foci increases upon DNA replication stress negative regulation of transposition, RNA-mediated|double-strand break repair molecular_function Cul8-RING ubiquitin ligase complex|nucleus
YDR265W YDR265W PEX10 hom Verified 0.786409949079097 0.215813678325845 no 1066 0.213751427093846 731 NA FT PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION Peroxisomal membrane E3 ubiquitin ligase, required for for Ubc4p-dependent Pex5p ubiquitination and peroxisomal matrix protein import; contains zinc-binding RING domain; mutations in human homolog cause various peroxisomal disorders protein import into peroxisome matrix|protein ubiquitination ubiquitin-protein ligase activity|protein binding peroxisomal membrane
YCR075C YCR075C ERS1 hom Verified 0.784282996857784 0.216437037081771 no 1067 0.203830797241053 703 NA Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains L-cystine transport|transmembrane transport L-cystine transmembrane transporter activity endosome|integral to membrane|fungal-type vacuole
YOL117W YOL117W RRI2 hom Verified 0.783920344381096 0.21654342571716 no 1068 0.208111649803129 729 NA FT SIGNALING NUCLEUS Subunit of the COP9 signalosome (CSN) complex that cleaves the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; plays a role in the mating pheromone response adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|cullin deneddylation molecular_function signalosome
YER141W YER141W COX15 hom Verified 0.783861963436798 0.216560555323588 no 1069 0.197490128134635 674 NA FT OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM MITOCHONDRION Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase heme a biosynthetic process oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor mitochondrion|integral to membrane|mitochondrial inner membrane
YGR240C YGR240C PFK1 hom Verified 0.783197645702608 0.216755528605384 no 1070 0.250049516385783 876 NA FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Alpha subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes proton transport|glycolysis 6-phosphofructokinase activity mitochondrion|6-phosphofructokinase complex|cytoplasm
YKR075C_p YKR075C YKR075C hom Uncharacterized 0.782245850814041 0.217035051539404 no 1071 0.222421029470933 776 NA FT NUCLEUS Protein of unknown function; similar to YOR062Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS biological_process molecular_function nucleus|cytoplasm
YHR171W YHR171W ATG7 hom Verified 0.781287358357938 0.217316751808973 no 1072 0.26691424021605 908 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS MITOCHONDRION Autophagy-related protein and dual specificity member of the E1 family of ubiquitin-activating enzymes; mediates the conjugation of Atg12p with Atg5p and Atg8p with phosphatidylethanolamine, required steps in autophagosome formation C-terminal protein lipidation|protein modification by small protein conjugation|piecemeal microautophagy of nucleus|mitochondrion degradation|macroautophagy|CVT pathway APG8 activating enzyme activity|APG12 activating enzyme activity cytosol|mitochondrion|membrane|pre-autophagosomal structure
YNL239W YNL239W LAP3 hom Verified 0.780566073992414 0.217528875945759 no 1073 0.206225231586959 687 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|PROTEOLYSIS MITOCHONDRION Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH response to antibiotic|negative regulation of transcription from RNA polymerase II promoter|homocysteine catabolic process double-stranded DNA binding|cysteine-type peptidase activity|mRNA binding|single-stranded DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding mitochondrion|cytoplasm
YOR052C YOR052C YOR052C hom Verified 0.779919701225517 0.217719070659022 no 1074 0.216210435376105 750 NA FT NUCLEUS Nuclear protein of unknown function; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner and by weak acid; transcriptionally regulated by Rpn4p along with proteasome subunit genes; putative ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus
YCR028C YCR028C FEN2 hom Verified 0.779836638165193 0.217743518858425 no 1075 0.242326989477997 801 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION PLASMA MEMBRANE Plasma membrane H+-pantothenate symporter; confers sensitivity to the antifungal agent fenpropimorph; relocalizes from vacuole to cytoplasm upon DNA replication stress pantothenate transmembrane transport|endocytosis pantothenate transmembrane transporter activity integral to membrane|plasma membrane
YDR222W_p YDR222W YDR222W hom Uncharacterized 0.779744780223516 0.217770557525707 no 1076 0.249308437575941 841 NA FT RESPONSE TO OXIDATIVE STRESS Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern biological_process molecular_function cytoplasm
YNL134C YNL134C YNL134C hom Verified 0.779437189204264 0.217861111987235 no 1077 0.193635596680125 598 NA FT OXIDATION-REDUCTION PROCESS NUCLEUS Protein of unknown function; similar to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress biological_process alcohol dehydrogenase (NADP+) activity nucleus|cytoplasm
YDR512C YDR512C EMI1 hom Verified 0.779125352570248 0.217952938517573 no 1078 0.213254789139003 743 NA FT TRANSCRIPTION FROM RNA POL II|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|MITOCHONDRION ORGANIZATION Non-essential protein required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation; contains twin cysteine-x9-cysteine motifs ascospore formation|mitochondrial respiratory chain complex assembly|positive regulation of transcription from RNA polymerase II promoter molecular_function cellular_component
YDR271C_d YDR271C YDR271C hom Dubious 0.779054418366916 0.217973829626863 no 1079 0.250884522916028 856 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W Unknown Unknown Unknown
YOR320C YOR320C GNT1 hom Verified 0.778858727273362 0.218031469360943 no 1080 0.2136204047346 713 NA FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|GOLGI APPARATUS N-acetylglucosaminyltransferase capable of modification of N-linked glycans in the Golgi apparatus protein N-linked glycosylation acetylglucosaminyltransferase activity Golgi medial cisterna
YGL025C YGL025C PGD1 hom Verified 0.778335766263314 0.218185547756767 no 1081 0.287090868266392 982 NA FF|FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II repressing transcription factor binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription factor recruiting transcription factor activity core mediator complex
YAL060W YAL060W BDH1 hom Verified 0.777972977478036 0.218292471955203 no 1082 0.226248069993844 748 NA FT OXIDATION-REDUCTION PROCESS NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source alcohol metabolic process|butanediol biosynthetic process (R,R)-butanediol dehydrogenase activity cytoplasm
YLL055W YLL055W YCT1 hom Verified 0.77796330948625 0.218295321800936 no 1083 0.192707628703244 633 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|PLASMA MEMBRANE High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene cysteine transport ion transmembrane transporter activity|cysteine transmembrane transporter activity integral to membrane|endoplasmic reticulum
YCL046W_d YCL046W YCL046W hom Dubious 0.776980498335216 0.218585138067019 no 1084 0.239703160342804 843 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YCL045C Unknown Unknown Unknown
YOR284W YOR284W HUA2 hom Verified 0.77687816231507 0.218615328152904 no 1085 0.21421509454181 712 NA Cytoplasmic protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly biological_process molecular_function cytoplasm
YGR088W YGR088W CTT1 hom Verified 0.776665840554282 0.218677972719958 no 1086 0.170682224872712 542 NA FT OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide response to reactive oxygen species catalase activity cytoplasm
YPL123C YPL123C RNY1 hom Verified 0.775762763965248 0.218944536755393 no 1087 0.194597663435547 656 NA Vacuolar RNase of the T(2) family, relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; promotes apoptosis under stress conditions and this function is independent of its catalytic activity cell morphogenesis|RNA catabolic process|apoptotic process endoribonuclease activity cytosol|extracellular region|vacuole
YBR104W YBR104W YMC2 hom Verified 0.773406347586417 0.219640967265163 no 1088 0.186277999594923 635 NA FT MITOCHONDRION Putative mitochondrial inner membrane transporter; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; YMC2 has a paralog, YMC1, that arose from the whole genome duplication mitochondrial transport|transmembrane transport organic acid transmembrane transporter activity mitochondrion|integral to membrane
YNL105W_d YNL105W RRT16 hom Dubious 0.772229584130123 0.219989231244919 no 1089 0.185665226907223 599 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription Unknown Unknown Unknown
YMR074C YMR074C YMR074C hom Verified 0.766449451204062 0.221704459100088 no 1090 0.198775539307727 673 NA FT NUCLEUS Protein with homology to human PDCD5; PDCD5 is involved in programmed cell death; N-terminal region forms a conserved triple-helix bundle structure; overexpression promotes H2O2-induced apoptosis; YMR074C is not an essential gene; protein abundance increases in response to DNA replication stress apoptotic process molecular_function nucleus|cytoplasm
YNR055C YNR055C HOL1 hom Verified 0.764097676104935 0.222404518536794 no 1091 0.210057846416813 719 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION|PLASMA MEMBRANE Putative transporter in the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; mutations in membrane-spanning domains permit cation and histidinol uptake organic alcohol transport|cation transport alcohol transmembrane transporter activity|inorganic cation transmembrane transporter activity mitochondrion|integral to membrane|plasma membrane
YOR375C YOR375C GDH1 hom Verified 0.763689946724306 0.222526016592219 no 1092 0.211451998902823 718 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS NUCLEUS NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources; GDH1 has a paralog, GDH3, that arose from the whole genome duplication glutamate biosynthetic process|ammonia assimilation cycle glutamate dehydrogenase (NADP+) activity nucleus|cytoplasm
YBR292C_d YBR292C YBR292C hom Dubious 0.763339763092669 0.222630396966978 no 1093 0.217610910586681 796 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene Unknown Unknown Unknown
YIL164C YIL164C NIT1 hom Verified 0.763048977025679 0.222717093723602 no 1094 0.200373986110048 686 NA Nitrilase, member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene biological_process nitrilase activity cellular_component
YFR019W YFR019W FAB1 hom Verified 0.762162286036561 0.222981576021536 no 1095 0.239006691760276 804 NA FT LIPID METABOLISM MITOCHONDRION 1-phosphatidylinositol-3-phosphate 5-kinase; vacuolar membrane kinase that generates phosphatidylinositol (3,5)P2, which is involved in vacuolar sorting and homeostasis phosphatidylinositol phosphorylation 1-phosphatidylinositol-3-phosphate 5-kinase activity|phosphatidylinositol-3-phosphate binding endosome membrane|mitochondrion|fungal-type vacuole membrane|PAS complex
YGR068C YGR068C ART5 hom Verified 0.762067326837349 0.223009911064189 no 1096 0.226648049304879 753 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION Protein proposed to regulate the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membrane ubiquitin-dependent endocytosis ubiquitin protein ligase binding cellular_component
YNR070W_p YNR070W PDR18 hom Uncharacterized 0.760578963552225 0.223454294281005 no 1097 0.202269697106362 711 NA FT NUCLEOTIDE METABOLISM MITOCHONDRION Putative transporter of the ATP-binding cassette (ABC) family, implicated in pleiotropic drug resistance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies transport ATPase activity, coupled to transmembrane movement of substances mitochondrion|integral to membrane|membrane
YBL015W YBL015W ACH1 hom Verified 0.757259892452454 0.224447087254689 no 1098 0.207044724343003 658 NA FT KETONE METABOLISM|COFACTOR METABOLISM MITOCHONDRION Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth acetate metabolic process acetate CoA-transferase activity|acetyl-CoA hydrolase activity cytosol|mitochondrion
YOL071W YOL071W EMI5 hom Verified 0.756699645062163 0.22461491375854 no 1099 0.185455276494712 608 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Subunit of succinate dehydrogenase, which couples succinate oxidation to ubiquinone reduction; required for FAD cofactor attachment to Sdh1p; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma) protein-FAD linkage|cellular respiration|mitochondrial electron transport, succinate to ubiquinone|ascospore formation|tricarboxylic acid cycle|positive regulation of transcription from RNA polymerase II promoter succinate dehydrogenase (ubiquinone) activity mitochondrial respiratory chain complex II|mitochondrion|mitochondrial matrix
YGR044C YGR044C RME1 hom Verified 0.756375658007765 0.224711999101427 no 1100 0.153525215951425 542 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CELL DIVISION NUCLEUS Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-alpha2 regulator; mediates cell type control of sporulation; relocalizes from nucleus to cytoplasm upon DNA replication stress negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription during meiosis|negative regulation of meiosis|positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription involved in G1/S phase of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity nucleus
YNL259C YNL259C ATX1 hom Verified 0.754532014671631 0.225264914566289 no 1101 0.235570120970849 822 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake copper ion transport|cellular response to oxidative stress|cellular iron ion homeostasis copper chaperone activity cytosol
YAR035W YAR035W YAT1 hom Verified 0.754307462050827 0.225332311327661 no 1102 0.209736750902831 724 NA FT KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated carnitine metabolic process|alcohol metabolic process carnitine O-acetyltransferase activity mitochondrion
YOR369C YOR369C RPS12 hom Verified 0.753170295277085 0.225673793494196 no 1103 0.219006812709412 754 NA FT TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S12, no bacterial homolog cytoplasmic translation structural constituent of ribosome cytosolic small ribosomal subunit
YGL196W YGL196W DSD1 hom Verified 0.752707070477376 0.225812980110721 no 1104 0.228695714907455 801 NA FT KETONE METABOLISM|AMINO ACID METABOLISM D-serine dehydratase (aka D-serine ammonia-lyase); converts D-serine to pyruvate and ammonia by a reaction dependent on pyridoxal 5'-phosphate and zinc; may play a role in D-serine detoxification; L-serine is not a substrate D-serine metabolic process D-serine ammonia-lyase activity cellular_component
YPL135W YPL135W ISU1 hom Verified 0.751701349328068 0.226115339392932 no 1105 0.233441742727072 826 NA FT RNA PROCESSING|ION HOMEOSTASIS|ION HOMEOSTASIS|COFACTOR METABOLISM MITOCHONDRION Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable cellular iron ion homeostasis|iron-sulfur cluster assembly|tRNA wobble uridine modification ferrous iron binding mitochondrion|mitochondrial matrix
YDL182W YDL182W LYS20 hom Verified 0.75166893373923 0.226125088596875 no 1106 0.200093795375608 659 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS|MITOCHONDRION Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS20 has a paralog, LYS21, that arose from the whole genome duplication lysine biosynthetic process via aminoadipic acid homocitrate synthase activity mitochondrion|nucleus
YDR305C YDR305C HNT2 hom Verified 0.750964444824545 0.226337026997678 no 1107 0.207775613436323 667 NA FT NUCLEUS|MITOCHONDRION Dinucleoside triphosphate hydrolase; has similarity to the tumor suppressor FHIT and belongs to the histidine triad (HIT) superfamily of nucleotide-binding proteins nucleoside catabolic process hydrolase activity|nucleoside-triphosphatase activity mitochondrion|nucleus|cytoplasm
YHR082C YHR082C KSP1 hom Verified 0.749967388704136 0.22663717297886 no 1108 0.231417552036955 815 NA FT PROTEIN LOCALIZATION|SIGNALING|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS NUCLEUS Serine/threonine protein kinase; associates with TORC1 and likely involved in TOR signaling cascades; negative regulator of autophagy; nuclear translocation required for haploid filamentous growth; regulates filamentous growth induced nuclear translocation of Bcy1p, Fus3p, and Sks1p; overproduction causes allele-specific suppression of prp20-10; protein abundance increases in response to DNA replication stress TOR signaling cascade|protein phosphorylation|Unknown|cellular protein localization|regulation of filamentous growth|negative regulation of macroautophagy protein serine/threonine kinase activity|protein kinase activity nucleus|cytoplasm
YLR030W_p YLR030W YLR030W hom Uncharacterized 0.745164117689169 0.228086255935006 no 1109 0.208137820122752 710 NA Putative protein of unknown function biological_process molecular_function cellular_component
YNL133C YNL133C FYV6 hom Verified 0.744910479902288 0.228162919640128 no 1110 0.265410656448573 934 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Protein of unknown function, required for survival upon exposure to K1 killer toxin; proposed to regulate double-strand break repair via non-homologous end-joining double-strand break repair via nonhomologous end joining molecular_function nucleus
YPR075C YPR075C OPY2 hom Verified 0.742706010636529 0.228829844967429 no 1111 0.210104803047354 728 NA FT CELL CYCLE|SIGNALING PLASMA MEMBRANE Integral membrane protein that acts as a membrane anchor for Ste50p; involved in the signaling branch of the high-osmolarity glycerol (HOG) pathway and as a regulator of the filamentous growth pathway; overproduction blocks cell cycle arrest in the presence of mating pheromone; relocalizes from vacuole to plasma membrane upon DNA replication stress cell cycle arrest in response to pheromone|osmosensory signaling pathway molecular_function integral to membrane|plasma membrane|fungal-type vacuole|cytoplasm
YIL120W YIL120W QDR1 hom Verified 0.742651940144668 0.228846216827907 no 1112 0.212854657906642 717 NA FT PLASMA MEMBRANE Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for resistance to quinidine, ketoconazole, fluconazole, and barban; QDR1 has a paralog, AQR1, that arose from the whole genome duplication drug transmembrane transport drug transmembrane transporter activity integral to membrane|plasma membrane
YLR148W YLR148W PEP3 hom Verified 0.742185432821811 0.228987496642895 no 1113 0.294112112172672 1022 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT Component of CORVET tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis regulation of SNARE complex assembly|regulation of vacuole fusion, non-autophagic|vacuole fusion, non-autophagic|late endosome to vacuole transport|vesicle docking involved in exocytosis|Golgi to endosome transport phosphatidylinositol binding|protein binding, bridging fungal-type vacuole membrane|HOPS complex|proteasome storage granule|CORVET complex|extrinsic to vacuolar membrane
YPR100W YPR100W MRPL51 hom Verified 0.741549153285248 0.229180270139818 no 1114 0.261316510936755 880 NA FT TRANSLATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation|aerobic respiration structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YNL339C YNL339C YRF1-6 hom Verified 0.740696452063865 0.229438755527998 no 1115 0.208455236056318 682 NA FT NUCLEUS Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p telomere maintenance via recombination DNA helicase activity nucleus
YDR095C_d YDR095C YDR095C hom Dubious 0.740101549325057 0.229619189345413 no 1116 0.234216839025402 750 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YMR291W YMR291W TDA1 hom Verified 0.738649397926137 0.230059960069685 no 1117 0.218053071209519 740 NA FT PROTEIN PHOSPHORYLATION NUCLEUS Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; relocalizes from nucleus to cytoplasm upon DNA replication stress protein phosphorylation protein kinase activity nucleus|cytoplasm
YNR008W YNR008W LRO1 hom Verified 0.738224501751558 0.230189018047382 no 1118 0.233546150742057 813 NA FT LIPID METABOLISM ENDOPLASMIC RETICULUM Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase lipid storage|triglyceride biosynthetic process phospholipid:diacylglycerol acyltransferase activity lipid particle|perinuclear endoplasmic reticulum
YIL025C_d YIL025C YIL025C hom Dubious 0.737782850666257 0.230323208076165 no 1119 0.269712329662042 935 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YEL052W YEL052W AFG1 hom Verified 0.73573120469665 0.230947147689177 no 1120 0.216676900877878 724 NA FT PROTEIN LOCALIZATION|PROTEOLYSIS|RESPONSE TO OXIDATIVE STRESS|PEROXISOME ORGANIZATION MITOCHONDRION Conserved protein that may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain protein import into peroxisome matrix|cellular response to oxidative stress|misfolded or incompletely synthesized protein catabolic process molecular_function mitochondrion|mitochondrial inner membrane
YKR090W YKR090W PXL1 hom Verified 0.735202898082643 0.231107967153004 no 1121 0.233997283698582 803 NA FT SIGNALING SITE OF POLARIZED GROWTH Protein that localizes to sites of polarized growth; required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; contains LIM domains and has similarity to metazoan paxillin; relocalizes from bud neck to cytoplasm upon DNA replication stress maintenance of cell polarity|regulation of Rho protein signal transduction Rho GDP-dissociation inhibitor activity incipient cellular bud site|cellular bud|mating projection tip|cellular bud neck|cytoplasm|cellular bud tip
YIL020C YIL020C HIS6 hom Verified 0.735166789610719 0.231118961053368 no 1122 0.229246611450349 777 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Phosphoribosyl-5-amino-1-phosphoribosyl-4-imidazolecarboxiamide isomerase, catalyzes the fourth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts histidine biosynthetic process 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity intracellular
YOR043W YOR043W WHI2 hom Verified 0.73461885838219 0.231285824787048 no 1123 0.203631587180416 685 NA FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CYTOSKELETON ORGANIZATION Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression response to salt stress|mitochondrion degradation|actin filament organization|endocytosis|response to heat|regulation of growth|response to stress phosphatase activator activity cellular_component
YGL053W YGL053W PRM8 hom Verified 0.73430106107847 0.231382635680005 no 1124 0.218933257943791 736 NA FT VESICLE-MEDIATED TRANSPORT ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Pheromone-regulated protein with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; forms a complex with Prp9p in the ER; member of DUP240 gene family biological_process molecular_function integral to membrane|endoplasmic reticulum|plasma membrane
YNR039C YNR039C ZRG17 hom Verified 0.733701417425169 0.231565367226706 no 1125 0.203137940192062 685 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Msc2p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; zinc-regulated directly through Zap1p; transcription induced under conditions of zinc deficiency zinc ion transport zinc ion transmembrane transporter activity|metal ion transmembrane transporter activity integral to membrane|endoplasmic reticulum
YHR039C YHR039C MSC7 hom Verified 0.732937498567583 0.231798275411214 no 1126 0.252722856010328 900 NA FT CELL CYCLE|OXIDATION-REDUCTION PROCESS ENDOPLASMIC RETICULUM Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids reciprocal meiotic recombination molecular_function integral to membrane|endoplasmic reticulum
YNR072W YNR072W HXT17 hom Verified 0.732838869453545 0.231828355559046 no 1127 0.223309069316235 794 NA FT PLASMA MEMBRANE Hexose transporter, up-regulated in media containing raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose hexose transport mannose transmembrane transporter activity|glucose transmembrane transporter activity|fructose transmembrane transporter activity integral to membrane|plasma membrane
YPR022C_p YPR022C YPR022C hom Uncharacterized 0.732089213243958 0.232057058596934 no 1128 0.242637392538258 802 NA FT NUCLEUS Putative transcription factor, as suggested by computational analysis; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS biological_process sequence-specific DNA binding nucleus|cytoplasm
YPL088W_p YPL088W YPL088W hom Uncharacterized 0.731963231596086 0.232095505052774 no 1129 0.22998685197979 774 NA FT OXIDATION-REDUCTION PROCESS Putative aryl alcohol dehydrogenase; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance cellular aldehyde metabolic process aryl-alcohol dehydrogenase (NAD+) activity cellular_component
YIR032C YIR032C DAL3 hom Verified 0.731821410939542 0.232138789420992 no 1130 0.238142132186542 809 NA FT PLASMA MEMBRANE Ureidoglycolate hydrolase, converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation; expression sensitive to nitrogen catabolite repression allantoin catabolic process ureidoglycolate hydrolase activity membrane
YDL175C YDL175C AIR2 hom Verified 0.731517320024357 0.232231614620989 no 1131 0.241231009500182 826 NA FT RNA PROCESSING NUCLEUS RNA-binding subunit of the TRAMP nuclear RNA surveillance complex; involved in nuclear RNA processing and degradation; involved in TRAMP complex assembly as a bridge between Mtr4p and Trf4p; stimulates the poly(A) polymerase activity of Pap2p in vitro; has 5 zinc knuckle motifs; AIR2 has a paralog, AIR1, that arose from the whole genome duplication nuclear polyadenylation-dependent CUT catabolic process|nuclear mRNA surveillance of mRNA 3'-end processing|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent snRNA catabolic process|ncRNA polyadenylation|tRNA modification polynucleotide adenylyltransferase activity|RNA binding|protein binding, bridging nucleolus|TRAMP complex
YGL135W YGL135W RPL1B hom Verified 0.73089525920058 0.232421565976488 no 1132 0.256467673901785 887 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L1B; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1B has a paralog, RPL1A, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YNL141W YNL141W AAH1 hom Verified 0.730402279281871 0.232572162780049 no 1133 0.234004401811071 821 NA FT NUCLEOTIDE METABOLISM NUCLEUS Adenine deaminase (adenine aminohydrolase), converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome adenine catabolic process|hypoxanthine salvage|purine-containing compound salvage adenine deaminase activity nucleus|cytoplasm
YDR221W YDR221W GTB1 hom Verified 0.729308362634863 0.232906528992831 no 1134 0.22257718092509 766 NA FT CARBOHYDRATE METABOLISM ENDOPLASMIC RETICULUM Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p; involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER; relocalizes from ER to cytoplasm upon DNA replication stress polysaccharide biosynthetic process|protein N-linked glycosylation alpha-glucosidase activity glucosidase II complex|endoplasmic reticulum|endoplasmic reticulum lumen
YBR297W YBR297W MAL33 hom Verified 0.728876763734971 0.233038524800868 no 1135 0.233805005809724 811 NA FT TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM NUCLEUS MAL-activator protein, part of complex locus MAL3; nonfunctional in genomic reference strain S288C cellular carbohydrate metabolic process|regulation of transcription, DNA-dependent sequence-specific DNA binding transcription factor activity nucleus
YIL060W_p YIL060W YIL060W hom Uncharacterized 0.728295752530306 0.233216280927225 no 1136 0.251668963555496 893 NA Putative protein of unknown function; mutant accumulates less glycogen than does wild type; null mutation results in a decrease in plasma membrane electron transport; YIL060W is not an essential gene biological_process molecular_function cellular_component
YKR006C YKR006C MRPL13 hom Verified 0.728121402428939 0.233269636741455 no 1137 0.230842855070631 826 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YDL122W YDL122W UBP1 hom Verified 0.72745724667808 0.233472948283848 no 1138 0.224236159654837 770 NA FT PROTEOLYSIS ENDOPLASMIC RETICULUM Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains protein deubiquitination ubiquitin-specific protease activity endoplasmic reticulum|cytoplasm
YBR128C YBR128C ATG14 hom Verified 0.727423746687745 0.233483205913439 no 1139 0.22645196540865 771 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION Autophagy-specific subunit of phosphatidylinositol 3-kinase complex I (with Vps34/15/30p); Atg14p targets complex I to the phagophore assembly site (PAS); required for localizing additional ATG proteins to the PAS; required for overflow degradation of misfolded proteins when ERAD is saturated; homolog of human Barkor piecemeal microautophagy of nucleus|ER-associated protein catabolic process|peroxisome degradation|macroautophagy|CVT pathway 1-phosphatidylinositol-3-kinase activity phosphatidylinositol 3-kinase complex I|fungal-type vacuole membrane|pre-autophagosomal structure|extrinsic to membrane
YDL154W YDL154W MSH5 hom Verified 0.726020869333777 0.233912988483987 no 1140 0.216751519493393 741 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Protein of the MutS family, forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis; msh5-Y823H mutation confers tolerance to DNA alkylating agents; homologs present in C. elegans and humans reciprocal meiotic recombination molecular_function nucleus
YGR033C YGR033C TIM21 hom Verified 0.725511690078327 0.234069087924236 no 1141 0.223298167843964 746 NA FT PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Nonessential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); interacts with the Translocase of the Outer Mitochondrial membrane (TOM complex) and with respiratory enzymes; may regulate TIM23 complex activity protein import into mitochondrial matrix molecular_function mitochondrion|mitochondrial inner membrane presequence translocase complex
YDL117W YDL117W CYK3 hom Verified 0.725100809173019 0.234195094020646 no 1142 0.230472231357174 769 NA FT CELL CYCLE|CELL DIVISION SITE OF POLARIZED GROWTH|CYTOSKELETON SH3-domain protein located in the bud neck and cytokinetic actin ring; relocalizes from bud neck to nucleus upon DNA replication stress; activates the chitin synthase activity of Chs2p during cytokinesis; suppressor of growth and cytokinesis defects of chs2 phospho-mutants barrier septum assembly involved in cell cycle cytokinesis|cytokinesis molecular_function cellular bud neck contractile ring|cellular bud neck|cytoplasm
YPR039W_d YPR039W YPR039W hom Dubious 0.72485283575556 0.23427115895096 no 1143 0.256013928479364 892 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified non essential genes ERV2/YPR037C and TIP41/YPR040W Unknown Unknown Unknown
YML076C YML076C WAR1 hom Verified 0.72472467530405 0.234310477056075 no 1144 0.208045299326231 708 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS|MITOCHONDRION Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively response to acid sequence-specific DNA binding transcription factor activity mitochondrion|nucleus
YOR312C YOR312C RPL20B hom Verified 0.724714767490739 0.234313516807666 no 1145 0.200396571892907 702 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L20B; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20B has a paralog, RPL20A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YPR201W YPR201W ARR3 hom Verified 0.724382622265498 0.234415432747851 no 1146 0.219029803222287 775 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Plasma membrane metalloid/H+ antiporter; transports arsenite and antimonite; required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite arsenite transport|antimonite transport antiporter activity|arsenite transmembrane transporter activity|antimonite transmembrane transporter activity integral to membrane|plasma membrane
YDR349C YDR349C YPS7 hom Verified 0.724124167650039 0.234494754316934 no 1147 0.23763862202013 821 NA FT CELL WALL ORG/BIOGENESIS|PROTEOLYSIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Putative GPI-anchored aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; located in the cytoplasm and endoplasmic reticulum fungal-type cell wall organization aspartic-type endopeptidase activity endoplasmic reticulum|cytoplasm
YGR037C YGR037C ACB1 hom Verified 0.723984471735274 0.234537634173013 no 1148 0.311843109687716 1080 NA FF|FT KETONE METABOLISM|LIPID METABOLISM NUCLEUS Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion; protein abundance increases in response to DNA replication stress long-chain fatty acid transport|chronological cell aging|fatty acid metabolic process long-chain fatty acid transporter activity|fatty-acyl-CoA binding extracellular region|nucleus|cytoplasm
YML094W YML094W GIM5 hom Verified 0.723946066603749 0.23454942344183 no 1149 0.227151463545695 794 NA FT PROTEIN COMPLEX ORG/BIOGENESIS Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it tubulin complex assembly tubulin binding prefoldin complex|cytoplasm
YIL156W YIL156W UBP7 hom Verified 0.723876889524701 0.23457065963886 no 1150 0.239659725927452 806 NA FT PROTEOLYSIS Ubiquitin-specific protease that cleaves ubiquitin-protein fusions protein deubiquitination ubiquitin-specific protease activity cytoplasm
YBR288C YBR288C APM3 hom Verified 0.722960902509378 0.234851952458555 no 1151 0.257075948821546 895 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway Golgi to vacuole transport|vesicle-mediated transport molecular_function AP-3 adaptor complex
YJL022W_d YJL022W YJL022W hom Dubious 0.72285812884168 0.234883525118424 no 1152 0.243945752974623 796 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130 Unknown Unknown Unknown
YBR214W YBR214W SDS24 hom Verified 0.720228998837807 0.235692006010474 no 1153 0.234792852052636 798 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL DIVISION Protein involved in cell separation during budding; one of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; may play an indirect role in fluid-phase endocytosis; protein abundance increases in response to DNA replication stress; SDS24 has a paralog, SDS23, that arose from the whole genome duplication endocytosis|cytokinetic cell separation molecular_function cytoplasm
YDL050C_d YDL050C YDL050C hom Dubious 0.718754306244365 0.236146158099537 no 1154 0.211219403872521 725 NA Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YJR145C YJR145C RPS4A hom Verified 0.717762162959264 0.236451973464887 no 1155 0.22896227392525 799 NA FT TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4A has a paralog, RPS4B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic small ribosomal subunit|cytoplasm|90S preribosome
YHR100C YHR100C GEP4 hom Verified 0.717378396616855 0.236570322927427 no 1156 0.299876080348227 1038 NA FF|FT LIPID METABOLISM|CARBOHYDRATE METABOLISM MITOCHONDRION Mitochondrial phosphatidylglycerophosphatase (PGP phosphatase), dephosphorylates phosphatidylglycerolphosphate to generate phosphatidylglycerol, an essential step during cardiolipin biosynthesis; null mutant is sensitive to tunicamycin, DTT cardiolipin biosynthetic process|phosphorylated carbohydrate dephosphorylation phosphatidylglycerophosphatase activity mitochondrion|mitochondrial matrix
YGL226W YGL226W MTC3 hom Verified 0.715481547427806 0.237155769488615 no 1157 0.225716079519439 770 NA FT MITOCHONDRION Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; mtc3 is synthetically sick with cdc13-1 biological_process molecular_function mitochondrion
YHL023C YHL023C NPR3 hom Verified 0.715109951282323 0.237270552684239 no 1158 0.254189461758823 841 NA FT CELL CYCLE|SIGNALING|RESPONSE TO NUTRIENT LEVELS Subunit of SEA (Seh1-associated), Npr2/3, and Iml1p complexes; Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation; SEA complex is a coatomer-related complex that associates dynamically with the vacuole; Iml1p complex (Iml1p-Npr2p-Npr3p) is required for non-nitrogen-starvation (NNS)-induced autophagy; required for Npr2p phosphorylation and Iml1p-Npr2p interaction; null mutant shows delayed meiotic DNA replication and double-strand break repair meiosis|regulation of TOR signaling cascade|cellular response to amino acid starvation molecular_function Seh1-associated complex|extrinsic to fungal-type vacuolar membrane
YDR209C_d YDR209C YDR209C hom Dubious 0.714514430693046 0.237454568036135 no 1159 0.223400686809952 765 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YDR210W. Unknown Unknown Unknown
YMR312W YMR312W ELP6 hom Verified 0.71404962119304 0.237598248193577 no 1160 0.243859241374605 831 NA FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity protein urmylation|regulation of transcription from RNA polymerase II promoter|tRNA wobble uridine modification ATPase activity|tRNA binding Elongator holoenzyme complex
YGR020C YGR020C VMA7 hom Verified 0.713372440926631 0.237807660957088 no 1161 0.28494834922875 1005 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane vacuolar acidification proton-transporting ATPase activity, rotational mechanism fungal-type vacuole membrane|vacuolar proton-transporting V-type ATPase, V1 domain|integral to membrane
YLR181C YLR181C VTA1 hom Verified 0.712484457915356 0.238082416172365 no 1162 0.230189747562539 787 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|VACUOLAR TRANSPORT Multivesicular body (MVB) protein involved in endosomal protein sorting; regulates Vps4p activity by promoting its oligomerization; has an N-terminal Vps60- and Did2- binding domain, a linker region, and a C-terminal Vps4p binding domain late endosome to vacuole transport via multivesicular body sorting pathway|positive regulation of protein oligomerization|late endosome to vacuole transport ATPase activator activity endosome|endosome membrane|multivesicular body
YDR370C YDR370C DXO1 hom Verified 0.712377656514036 0.238115473838938 no 1163 0.233770074940708 793 NA Protein with decapping and 5′-3′ exoRNase activity; similar to Rai1p biological_process molecular_function cytoplasm
YML007W YML007W YAP1 hom Verified 0.710641500584745 0.238653209539634 no 1164 0.261471345707372 885 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO OXIDATIVE STRESS NUCLEUS Basic leucine zipper (bZIP) transcription factor; required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; Yap1p is degraded in the nucleus after the oxidative stress has passed; mediates resistance to cadmium; YAP1 has a paralog, CAD1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance|response to heat|response to drug|response to singlet oxygen|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|response to metal ion sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nucleus|cytoplasm
YNL064C YNL064C YDJ1 hom Verified 0.707344877526354 0.239676091607268 no 1165 0.185937771312933 601 NA FT PROTEIN LOCALIZATION|PROTEOLYSIS|MITOCHONDRION ORGANIZATION Type I HSP40 co-chaperone; involved in regulation of HSP90 and HSP70 functions; critical for determining cell size at Start as a function of growth rate; involved in protein translocation across membranes; member of the DnaJ family protein refolding|ER-associated protein catabolic process|protein targeting to mitochondrion|protein targeting to ER|'de novo' protein folding unfolded protein binding|ATPase activator activity cytosol|TRC complex|perinuclear region of cytoplasm
YNL274C YNL274C GOR1 hom Verified 0.707039907319103 0.239770839065315 no 1166 0.217658065423169 717 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS NUCLEUS|MITOCHONDRION Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress glyoxylate catabolic process|metabolic process oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|glyoxylate reductase activity mitochondrion|nucleus|cytoplasm
YGR032W YGR032W GSC2 hom Verified 0.707011489637174 0.239779668847549 no 1167 0.218956335494407 760 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM PLASMA MEMBRANE|CYTOSKELETON Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p) ascospore wall assembly|(1->3)-beta-D-glucan biosynthetic process 1,3-beta-D-glucan synthase activity 1,3-beta-D-glucan synthase complex|integral to membrane|actin cap|prospore membrane
YOL045W YOL045W PSK2 hom Verified 0.706922588536993 0.239807292842778 no 1168 0.258378513339485 843 NA FT SIGNALING|TRANSLATION|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION PAS-domain containing serine/threonine protein kinase; regulates sugar flux and translation in response to an unknown metabolite by phosphorylating Ugp1p and Gsy2p (sugar flux) and Caf20p, Tif11p and Sro9p (translation); PSK2 has a paralog, PSK1, that arose from the whole genome duplication regulation of (1->6)-beta-D-glucan biosynthetic process|negative regulation of glycogen biosynthetic process|protein phosphorylation protein serine/threonine kinase activity mitochondrion|cytoplasm
YHR015W YHR015W MIP6 hom Verified 0.70564703361693 0.240203833632393 no 1169 0.217108228735548 723 NA FT RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE Putative RNA-binding protein; interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export; MIP6 has a paralog, PES4, that arose from the whole genome duplication mRNA export from nucleus RNA binding nuclear pore
YPR074C YPR074C TKL1 hom Verified 0.704292902682053 0.240625192653263 no 1170 0.285684947371538 990 NA FF|FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication pentose-phosphate shunt transketolase activity cytoplasm
YDL118W_d YDL118W YDL118W hom Dubious 0.703401086931389 0.240902914679469 no 1171 0.274600318176436 939 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS Dubious open reading frame, unlikely to encode a protein; overlaps almost completely with YDL119C; mutations that would affect both YDL118W and YDL119C confer defective telomere maintenance and are synthetically sick or lethal with alpha-synuclein biological_process molecular_function cellular_component
YLR451W YLR451W LEU3 hom Verified 0.703257999673156 0.240947489979057 no 1172 0.238369412028788 789 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Zinc-knuckle transcription factor, repressor and activator; regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; acts as a repressor in leucine-replete conditions and as an activator in the presence of alpha-isopropylmalate, an intermediate in leucine biosynthesis that accumulates during leucine starvation negative regulation of transcription from RNA polymerase II promoter|Unknown|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YBR130C YBR130C SHE3 hom Verified 0.702761331150105 0.241102249589818 no 1173 0.245701126318364 820 NA FT RNA LOCALIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH|CYTOSKELETON Protein that acts as an adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritance mating type switching|endoplasmic reticulum inheritance|intracellular mRNA localization mRNA binding actin cap|cytoplasm|cellular bud tip
YBR101C YBR101C FES1 hom Verified 0.700278082467794 0.241876828330568 no 1174 0.24051494297198 849 NA FT TRANSLATION RIBOSOME Hsp70 (Ssa1p) nucleotide exchange factor; cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum; protein abundance increases in response to DNA replication stress cytoplasmic translation adenyl-nucleotide exchange factor activity cytosol|cytosolic ribosome
YGL161C YGL161C YIP5 hom Verified 0.699474790004784 0.242127681252925 no 1175 0.246406187426927 847 NA FT GOLGI APPARATUS Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport biological_process Rab GTPase binding integral to membrane|Golgi apparatus
YPL106C YPL106C SSE1 hom Verified 0.69788207107898 0.242625473835331 no 1176 0.263516966940425 902 NA ATPase component of the heat shock protein Hsp90 chaperone complex; binds unfolded proteins; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm; SSE1 has a paralog, SSE2, that arose from the whole genome duplication protein folding|protein refolding peptide binding|adenyl-nucleotide exchange factor activity|ATP binding polysome|cytoplasm
YGR174C YGR174C CBP4 hom Verified 0.69619217453941 0.243154243868369 no 1177 0.237360974540356 793 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial protein required for assembly of cytochrome bc1 complex; interacts with the Cbp3p-Cbp6p complex and newly synthesized cytochrome b (Cobp) to promote assembly of Cobp into the cytochrome bc1 complex mitochondrial respiratory chain complex III assembly molecular_function mitochondrion|integral to mitochondrial membrane
YOL053W YOL053W AIM39 hom Verified 0.694975320728321 0.243535383968104 no 1178 0.21068242575819 686 NA FT MITOCHONDRION Putative protein of unknown function; null mutant displays elevated frequency of mitochondrial genome loss biological_process molecular_function cellular_component
YBR215W YBR215W HPC2 hom Verified 0.69417718493622 0.243785549322317 no 1179 0.243092957747623 862 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CHROMATIN ORGANIZATION NUCLEUS Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; mutants display synthetic defects with subunits of FACT, a complex that allows passage of RNA Pol II through nucleosomes DNA replication-independent nucleosome assembly|regulation of transcription involved in G1/S phase of mitotic cell cycle|transcription elongation from RNA polymerase II promoter nucleosome binding|DNA binding HIR complex|nucleus
YPL037C YPL037C EGD1 hom Verified 0.694004412124467 0.243839720985512 no 1180 0.255172163523533 855 NA FT PROTEIN LOCALIZATION NUCLEUS Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b 'de novo' cotranslational protein folding unfolded protein binding nascent polypeptide-associated complex
YDR218C YDR218C SPR28 hom Verified 0.693800489233896 0.243903667888318 no 1181 0.224866613306483 753 NA FT CELL CYCLE|CELL DIVISION SITE OF POLARIZED GROWTH|CYTOSKELETON Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; meiotic septin expressed at high levels during meiotic divisions and ascospore formation sexual sporulation resulting in formation of a cellular spore structural molecule activity spindle microtubule|meiotic spindle|septin complex|prospore membrane|ascospore wall
YLR102C YLR102C APC9 hom Verified 0.692431584608514 0.244333168283451 no 1182 0.23162440701162 805 NA FT CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION NUCLEUS UBIQUITIN LIGASE COMPLEX Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition chromatin assembly|protein ubiquitination ubiquitin-protein ligase activity anaphase-promoting complex
YMR078C YMR078C CTF18 hom Verified 0.692341642618534 0.244361402278835 no 1183 0.21947372122558 734 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS|MITOCHONDRION|CHROMOSOME Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint maintenance of DNA trinucleotide repeats|double-strand break repair via homologous recombination|DNA replication initiation|mitotic sister chromatid cohesion molecular_function mitochondrion|nuclear replication fork|Ctf18 RFC-like complex
YLR392C YLR392C ART10 hom Verified 0.692164231749006 0.24441709908141 no 1184 0.20527815191877 707 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION Protein of unknown function that contains 2 PY motifs and is ubiquinated by Rsp5p; overexpression confers resistance to arsenite; green fluorescent protein (GFP)-fusion protein localizes it to the cytoplasm; non-essential gene biological_process molecular_function cytoplasm
YER123W YER123W YCK3 hom Verified 0.692090291937123 0.244440313946328 no 1185 0.283440805885911 999 NA FT VESICLE-MEDIATED TRANSPORT|PROTEIN PHOSPHORYLATION ENDOMEMBRANE SYSTEM|NUCLEUS|PLASMA MEMBRANE Palmitoylated, vacuolar membrane-localized casein kinase I isoform; negatively regulates vacuole fusion during hypertonic stress via phosphorylation of Vps41p; shares essential functions with Hrr25p; regulates vesicle fusion in AP-3 pathway vesicle-mediated transport|protein phosphorylation protein serine/threonine kinase activity|protein kinase activity fungal-type vacuole membrane|plasma membrane|nucleus|fungal-type vacuole
YNL130C YNL130C CPT1 hom Verified 0.691772665692574 0.244540052493998 no 1186 0.230813198202815 823 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS Cholinephosphotransferase; required for phosphatidylcholine biosynthesis and for inositol-dependent regulation of EPT1 transcription; CPT1 has a paralog, EPT1, that arose from the whole genome duplication CDP-choline pathway diacylglycerol cholinephosphotransferase activity mitochondrial outer membrane|integral to membrane|Golgi apparatus
YKL087C YKL087C CYT2 hom Verified 0.691670130436033 0.244572254505705 no 1187 0.244852829555593 838 NA FT PROTEIN COMPLEX ORG/BIOGENESIS MITOCHONDRION Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1 cytochrome c-heme linkage holocytochrome-c synthase activity mitochondrion|mitochondrial intermembrane space
YOR017W YOR017W PET127 hom Verified 0.691398930045656 0.244657438150887 no 1188 0.225739194727059 763 NA FT RNA PROCESSING|MITOCHONDRION ORGANIZATION MITOCHONDRION Protein with a role in 5'-end processing of mitochondrial RNAs, located in the mitochondrial membrane mitochondrial RNA 5'-end processing molecular_function mitochondrial envelope|mitochondrion
YPR031W YPR031W NTO1 hom Verified 0.691238589884287 0.244707808274775 no 1189 0.272139769543255 915 NA FT CHROMATIN ORGANIZATION NUCLEUS HISTONE ACETYLTRANSFERASE Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3 histone acetylation histone acetyltransferase activity|methylated histone residue binding nucleus|NuA3 histone acetyltransferase complex|cytoplasm
YMR182W-A_p YMR182W-A YMR182W-A hom Uncharacterized 0.691108944456361 0.244748539871552 no 1190 0.210430091685627 707 NA Putative protein of unknown function biological_process molecular_function cellular_component
YBR067C YBR067C TIP1 hom Verified 0.690869123453159 0.244823895707111 no 1191 0.242113500638233 844 NA FT CELL WALL ORG/BIOGENESIS Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins fungal-type cell wall organization structural constituent of cell wall|lipase activity fungal-type cell wall
YKL100C_p YKL100C YKL100C hom Uncharacterized 0.690370712639467 0.244980544794225 no 1192 0.216372710250637 712 NA FT PROTEOLYSIS Putative protein of unknown function with similarity to a human minor histocompatibility antigen and signal peptide peptidases; YKL100C is not an essential gene biological_process molecular_function integral to membrane
YPL062W_d YPL062W YPL062W hom Dubious 0.690292918667189 0.245005000080738 no 1193 0.271078428425015 942 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPL062W is not an essential gene; homozygous diploid mutant shows a decrease in glycogen accumulation Unknown Unknown Unknown
YGR077C YGR077C PEX8 hom Verified 0.689835261098423 0.245148895743986 no 1194 0.165738063185521 576 NA FT PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p protein targeting to peroxisome|peroxisome organization peroxisome targeting sequence binding peroxisomal matrix|peroxisomal membrane|extrinsic to intraperoxisomal membrane
YDR411C YDR411C DFM1 hom Verified 0.689156396615742 0.245362426468634 no 1195 0.221444092790656 740 NA FT SIGNALING|PROTEOLYSIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM UBIQUITIN LIGASE COMPLEX Endoplasmic reticulum (ER) localized protein involved in ER-associated protein degradation (ERAD), ER stress and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process molecular_function Doa10p ubiquitin ligase complex|integral to membrane|endoplasmic reticulum|Hrd1p ubiquitin ligase ERAD-L complex
YHR098C YHR098C SFB3 hom Verified 0.689141417046432 0.245367139284537 no 1196 0.243964011180371 880 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS|SITE OF POLARIZED GROWTH Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb2p cargo loading into COPII-coated vesicle signal sequence binding COPII vesicle coat|mating projection tip
YGL252C YGL252C RTG2 hom Verified 0.68771156838233 0.245817216785546 no 1197 0.264843979908968 924 NA FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|SIGNALING|RESPONSE TO NUTRIENT LEVELS NUCLEUS|CHROMOSOME HISTONE ACETYLTRANSFERASE Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p maintenance of DNA trinucleotide repeats|regulation of transcription from RNA polymerase II promoter|Unknown|nitrogen catabolite regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|mitochondria-nucleus signaling pathway|transcription factor import into nucleus RNA polymerase II transcription factor binding transcription factor activity SLIK (SAGA-like) complex|transcriptionally active chromatin|cytoplasm
YNL013C_d YNL013C YNL013C hom Dubious 0.687301022726879 0.245946527241934 no 1198 0.219060433361481 717 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF HEF3/YNL014W Unknown Unknown Unknown
YGR220C YGR220C MRPL9 hom Verified 0.687128425401238 0.246000901492773 no 1199 0.222982007555112 746 NA FT TRANSLATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit cytoplasmic translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YGR207C YGR207C CIR1 hom Verified 0.68657002338653 0.246176862019663 no 1200 0.208348928792752 664 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Mitochondrial protein that interacts with frataxin (Yfh1p); putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-beta; may have a role in oxidative stress response biological_process molecular_function mitochondrion
YAR030C_d YAR030C YAR030C hom Dubious 0.685241621018414 0.246595731890788 no 1201 0.240416459026924 845 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YAR029W and the verified gene PRM9 Unknown Unknown Unknown
YGR021W_p YGR021W YGR021W hom Uncharacterized 0.684692893976078 0.246768867042876 no 1202 0.256811731890655 898 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YOR016C YOR016C ERP4 hom Verified 0.684099465974483 0.246956179532288 no 1203 0.234463316789865 753 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport ER to Golgi vesicle-mediated transport molecular_function integral to membrane
YNL091W YNL091W NST1 hom Verified 0.683681301117082 0.24708821679619 no 1204 0.244190684278359 858 NA Protein of unknown function, mediates sensitivity to salt stress; interacts physically with the splicing factor Msl1p and also displays genetic interaction with MSL1 response to salt stress molecular_function cytoplasm
YDL114W_p YDL114W YDL114W hom Uncharacterized 0.683174659313931 0.247248241597317 no 1205 0.251072600590891 851 NA FT OXIDATION-REDUCTION PROCESS Putative short-chain dehydrogenase/reductase; YDL114W is not an essential gene biological_process molecular_function integral to membrane
YML112W YML112W CTK3 hom Verified 0.682878992290551 0.24734165478608 no 1206 0.303712449039025 1030 NA FF|FT RNA PROCESSING|RESPONSE TO DNA DAMAGE|TRANSLATION|PROTEIN PHOSPHORYLATION NUCLEUS Gamma subunit of C-terminal domain kinase I; CTDK-I phosphorylates RNA polymerase II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and also phosphorylates ribosomal protein Rps2p to increase translational fidelity; protein abundance increases in response to DNA replication stress mRNA 3'-end processing|positive regulation of translational fidelity|positive regulation of transcription from RNA polymerase I promoter|positive regulation of DNA-dependent transcription, elongation|protein phosphorylation cyclin-dependent protein kinase activity nucleoplasm|nucleolus|carboxy-terminal domain protein kinase complex
YGR035W-A_p YGR035W-A YGR035W-A hom Uncharacterized 0.68251441411582 0.24745686576757 no 1207 0.227638362540527 757 NA Putative protein of unknown function biological_process molecular_function cellular_component
YHR086W YHR086W NAM8 hom Verified 0.682481906991224 0.247467139792728 no 1208 0.249878211726749 806 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING NUCLEUS|MITOCHONDRION RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of REC107 pre-mRNA; Nam8p regulon embraces the meiotic pre-mRNAs of REC107, HFM1, AMA1 SPO22 and PCH2; the putative RNA binding domains RRM2 and RRM3 are required for Nam8p meiotic function mRNA splicing, via spliceosome|positive regulation of mRNA splicing, via spliceosome|mRNA splice site selection mRNA binding|RNA binding commitment complex|U1 snRNP|U2-type prespliceosome
YPL178W YPL178W CBC2 hom Verified 0.681687911994829 0.247718156299331 no 1209 0.217243128573118 741 NA FT RNA PROCESSING|RNA LOCALIZATION NUCLEUS Small subunit of the heterodimeric cap binding complex that also contains Sto1p, component of the spliceosomal commitment complex; interacts with Npl3p, possibly to package mRNA for export from the nucleus; contains an RNA-binding motif mRNA splicing, via spliceosome RNA cap binding commitment complex|nuclear cap binding complex
YNL079C YNL079C TPM1 hom Verified 0.680153082332158 0.24820376819551 no 1210 0.251486141434214 891 NA FF|FT VESICLE-MEDIATED TRANSPORT|CELL DIVISION|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION|RNA LOCALIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently; TPM1 has a paralog, TPM2, that arose from the whole genome duplication vacuole inheritance|exocytosis|intracellular mRNA localization|filamentous growth|budding cell apical bud growth|mitochondrion inheritance|budding cell isotropic bud growth|actin polymerization or depolymerization|actin filament organization|pseudohyphal growth|vesicle-mediated transport|establishment of cell polarity|actin filament bundle assembly actin lateral binding cellular bud neck contractile ring|actin filament bundle
YPL114W_d YPL114W YPL114W hom Dubious 0.678911660400723 0.248596918514923 no 1211 0.239579538017435 836 NA Dubious open reading frame, unlikely to encode a functional protein; largely overlaps ORF YPL113C; diploid deletion in BY4743 strain background exhibits high budding index Unknown Unknown Unknown
YJR091C YJR091C JSN1 hom Verified 0.678884427844763 0.248605546606631 no 1212 0.21807547141175 716 NA FT PROTEIN LOCALIZATION MITOCHONDRION Member of the Puf family of RNA-binding proteins, interacts with mRNAs encoding membrane-associated proteins; involved in localizing the Arp2/3 complex to mitochondria; overexpression causes increased sensitivity to benomyl nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|cellular protein complex localization|establishment of mitochondrion localization mRNA binding external side of mitochondrial outer membrane
YGL248W YGL248W PDE1 hom Verified 0.678370987149273 0.248768249892534 no 1213 0.23495127282677 803 NA FT SIGNALING|NUCLEOTIDE METABOLISM Low-affinity cyclic AMP phosphodiesterase, controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation cAMP-mediated signaling 3',5'-cyclic-AMP phosphodiesterase activity cellular_component
YIL155C YIL155C GUT2 hom Verified 0.67775661193888 0.248963012619623 no 1214 0.226724378790833 752 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM MITOCHONDRION Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner NADH oxidation|replicative cell aging|glycerol metabolic process glycerol-3-phosphate dehydrogenase activity mitochondrion|integral to mitochondrial outer membrane
YBR248C YBR248C HIS7 hom Verified 0.677282921132303 0.249113232448449 no 1215 0.237747284983256 814 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM Imidazole glycerol phosphate synthase (glutamine amidotransferase:cyclase), catalyzes the fifth step of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR), a purine precursor purine nucleoside monophosphate biosynthetic process|histidine biosynthetic process imidazoleglycerol-phosphate synthase activity intracellular
YIR018C-A_p YIR018C-A YIR018C-A hom Uncharacterized 0.676795567376471 0.249267835465273 no 1216 0.239042725696101 816 NA Putative protein of unknown function; identified by expression profiling and mass spectrometry biological_process molecular_function cellular_component
YDL127W YDL127W PCL2 hom Verified 0.675460857803657 0.249691505844446 no 1217 0.200937033677244 721 NA FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION NUCLEUS|SITE OF POLARIZED GROWTH Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; localizes to sites of polarized cell growth G1 phase of mitotic cell cycle|regulation of establishment or maintenance of cell polarity|regulation of cyclin-dependent protein kinase activity|septin ring organization cyclin-dependent protein kinase regulator activity cyclin-dependent protein kinase holoenzyme complex|incipient cellular bud site|nucleus|cellular bud neck|cellular bud tip
YCL063W YCL063W VAC17 hom Verified 0.675009761451281 0.249834781589246 no 1218 0.25075501313597 888 NA Phosphoprotein involved in vacuole inheritance; degraded in late M phase of the cell cycle; acts as a vacuole-specific receptor for myosin Myo2p vacuole inheritance protein anchor fungal-type vacuole membrane
YPR047W YPR047W MSF1 hom Verified 0.673917327036957 0.250181937779939 no 1219 0.281422427410111 994 NA FT KETONE METABOLISM|RNA PROCESSING|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial phenylalanyl-tRNA synthetase, active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase phenylalanyl-tRNA aminoacylation|mitochondrial phenylalanyl-tRNA aminoacylation phenylalanine-tRNA ligase activity mitochondrion
YNL209W YNL209W SSB2 hom Verified 0.673683877104718 0.250256157172481 no 1220 0.188587070252439 608 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION|RESPONSE TO NUTRIENT LEVELS Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; SSB2 has a paralog, SSB1, that arose from the whole genome duplication cellular response to glucose starvation|cytoplasmic translation|ribosomal subunit export from nucleus|rRNA processing|regulation of translational fidelity|'de novo' cotranslational protein folding unfolded protein binding|ATPase activity plasma membrane|polysome|cytoplasm
YBR006W YBR006W UGA2 hom Verified 0.672383747186611 0.250669713467357 no 1221 0.307895860582235 1050 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm cellular response to oxidative stress|gamma-aminobutyric acid catabolic process|glutamate decarboxylation to succinate succinate-semialdehyde dehydrogenase [NAD(P)+] activity cytoplasm
YKR091W YKR091W SRL3 hom Verified 0.67237078507465 0.250673838386882 no 1222 0.256724364442254 886 NA Cytoplasmic protein that, when overexpressed, suppresses the lethality of a rad53 null mutation; potential Cdc28p substrate nucleobase-containing compound metabolic process molecular_function cytoplasm
YDR210W_p YDR210W YDR210W hom Uncharacterized 0.671540004451226 0.250938291823742 no 1223 0.201282636494419 664 NA FT PLASMA MEMBRANE Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery biological_process molecular_function cellular_component
YMR084W_p YMR084W YMR084W hom Uncharacterized 0.67102497280693 0.251102310403885 no 1224 0.253437625224885 877 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Putative protein of unknown function; YMR084W and adjacent ORF YMR085W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1 biological_process molecular_function cellular_component
YPL272C_p YPL272C YPL272C hom Uncharacterized 0.669408835753118 0.251617358405569 no 1225 0.280860070810181 969 NA Putative protein of unknown function; gene expression induced in response to ketoconazole; YPL272C is not an essential gene biological_process molecular_function cellular_component
YLR189C YLR189C ATG26 hom Verified 0.668016715906949 0.252061461161285 no 1226 0.222049825947004 733 NA FT PROTEIN LOCALIZATION|LIPID METABOLISM|MEMBRANE ORGANIZATION|CARBOHYDRATE METABOLISM UDP-glucose:sterol glucosyltransferase, conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagy sterol metabolic process|ascospore-type prospore membrane assembly sterol 3-beta-glucosyltransferase activity cytoplasm
YGL180W YGL180W ATG1 hom Verified 0.667939210133421 0.252086198569927 no 1227 0.24526726354877 839 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Protein ser/thr kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for phagophore assembly site formation; during autophagy forms a complex with Atg13p and Atg17p piecemeal microautophagy of nucleus|mitochondrion degradation|protein phosphorylation|CVT pathway|autophagic vacuole assembly protein serine/threonine kinase activity|protein kinase activity cytosol|pre-autophagosomal structure|Atg1p signaling complex
YGR281W YGR281W YOR1 hom Verified 0.667771436089989 0.252139751161675 no 1228 0.264858430214196 908 NA FT NUCLEOTIDE METABOLISM PLASMA MEMBRANE Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter mediates export of many different organic anions including oligomycin; similar to human cystic fibrosis transmembrane receptor (CFTR) transport|response to drug xenobiotic-transporting ATPase activity integral to membrane|plasma membrane
YFR048W YFR048W RMD8 hom Verified 0.667096138642337 0.252355363223531 no 1229 0.25100795904389 867 NA FT CELL CYCLE Cytosolic protein required for sporulation biological_process molecular_function cytoplasm
YCR090C_p YCR090C YCR090C hom Uncharacterized 0.667072573316047 0.252362889023434 no 1230 0.204672106013439 699 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YCR090C is not an essential gene biological_process molecular_function nucleus|cytoplasm
YIL014W YIL014W MNT3 hom Verified 0.666913028140537 0.252413844328756 no 1231 0.227375829667863 807 NA FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Alpha-1,3-mannosyltransferase, adds the fourth and fifth alpha-1,3-linked mannose residues to O-linked glycans during protein O-glycosylation protein O-linked glycosylation alpha-1,3-mannosyltransferase activity cellular_component
YOL072W YOL072W THP1 hom Verified 0.666428976665455 0.252568473159247 no 1232 0.308436560030257 1064 NA FF|FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|RNA PROCESSING|RESPONSE TO DNA DAMAGE|CELL DIVISION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE Nuclear pore-associated protein; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; contains a PAM domain implicated in protein-protein binding mRNA export from nucleus|mRNA 3'-end processing|transcription-coupled nucleotide-excision repair|cellular bud site selection|nuclear retention of pre-mRNA at the site of transcription|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|transcription elongation from RNA polymerase II promoter double-stranded DNA binding|RNA binding nuclear envelope|nucleus|transcription export complex 2|nuclear pore
YLR352W_p YLR352W YLR352W hom Uncharacterized 0.664970757999954 0.253034598299056 no 1233 0.249205718581632 837 NA Putative protein of unknown function with similarity to F-box proteins; interacts with Skp1p and Cdc53p; YLR352W is not an essential gene biological_process molecular_function SCF ubiquitin ligase complex
YFR035C_p YFR035C YFR035C hom Uncharacterized 0.664786104163442 0.253093655868428 no 1234 0.240662369281402 828 NA Putative protein of unknown function, deletion mutant exhibits synthetic phenotype with alpha-synuclein biological_process molecular_function cellular_component
YGR034W YGR034W RPL26B hom Verified 0.663969587810663 0.253354888006589 no 1235 0.27069069868475 938 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L26B; binds to 5.8S rRNA; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26B has a paralog, RPL26A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YDL237W YDL237W AIM6 hom Verified 0.66362980116363 0.253463639386511 no 1236 0.258062428870046 882 NA Putative protein of unknown function, required for respiratory growth; YDL237W is not an essential gene biological_process molecular_function cellular_component
YAL014C YAL014C SYN8 hom Verified 0.66247707671506 0.253832760573275 no 1237 0.217862851409034 761 NA FT PROTEIN LOCALIZATION Endosomal SNARE related to mammalian syntaxin 8 transport SNAP receptor activity endosome
YJR103W YJR103W URA8 hom Verified 0.661377422358626 0.254185150667651 no 1238 0.225557983492262 732 NA FT KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM Minor CTP synthase isozyme (see also URA7); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA8 has a paralog, URA7, that arose from the whole genome duplication pyrimidine nucleobase biosynthetic process|CTP biosynthetic process|phospholipid biosynthetic process CTP synthase activity cytosol
YCR091W YCR091W KIN82 hom Verified 0.654870242544237 0.256275650374031 no 1239 0.231758505316719 821 NA FT MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION Putative serine/threonine protein kinase implicated in the regulation of phospholipid asymmetry through the activation of phospholipid translocases (flippases) Lem3p-Dnf1p/Dnf2p; similar to Fpk1p phospholipid translocation|protein phosphorylation|response to pheromone protein kinase activity cellular_component
YLR429W YLR429W CRN1 hom Verified 0.653664631398585 0.25666394732513 no 1240 0.24158564266888 830 NA FT CYTOSKELETON ORGANIZATION CYTOSKELETON Coronin, cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity; plays a role in regulation of actin patch assembly microtubule-based process|actin filament organization|actin cortical patch localization|Unknown|negative regulation of Arp2/3 complex-mediated actin nucleation microtubule binding|actin filament binding|protein binding, bridging Arp2/3 protein complex|actin cortical patch
YDL129W YDL129W YDL129W hom Verified 0.652459422738958 0.257052420616334 no 1241 0.216430148597931 720 NA FT NUCLEUS Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YDL129W is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress biological_process molecular_function nucleus|cytoplasm
YBR291C YBR291C CTP1 hom Verified 0.649938845147874 0.257865862525318 no 1242 0.266393840914456 925 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family mitochondrial citrate transport|transmembrane transport tricarboxylate secondary active transmembrane transporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YHR124W YHR124W NDT80 hom Verified 0.649529259888338 0.257998170107351 no 1243 0.24744305079838 888 NA FT CELL CYCLE|CELL DIVISION NUCLEUS|CHROMOSOME Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE) meiosis|transcription, DNA-dependent sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nuclear chromosome
YLR389C YLR389C STE23 hom Verified 0.646757738953574 0.258894373874389 no 1244 0.239029716114617 831 NA FT PROTEOLYSIS Metalloprotease involved, with homolog Axl1p, in N-terminal processing of pro-a-factor to the mature form; expressed in both haploids and diploids; member of the insulin-degrading enzyme family peptide pheromone maturation metallopeptidase activity|metalloendopeptidase activity extrinsic to membrane
YJR066W YJR066W TOR1 hom Verified 0.64645097151878 0.258993669626076 no 1245 0.238198037116203 835 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RIBOSOME BIOGENESIS|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS|PLASMA MEMBRANE PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication regulation of cell cycle|G1 phase of mitotic cell cycle|transcription of nuclear large rRNA transcript from RNA polymerase I promoter|regulation of cell growth|response to DNA damage stimulus|mitochondria-nucleus signaling pathway|ribosome biogenesis|meiosis|signal transduction|TOR signaling cascade|fungal-type cell wall organization|negative regulation of autophagy protein binding|protein kinase activity TORC1 complex|fungal-type vacuole membrane|endosome membrane|extrinsic to internal side of plasma membrane|plasma membrane|nucleus|Golgi membrane|cytoplasm
YMR210W YMR210W YMR210W hom Verified 0.646176958078153 0.259082380081201 no 1246 0.224903986636469 723 NA FT KETONE METABOLISM|LIPID METABOLISM Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification medium-chain fatty acid biosynthetic process transferase activity, transferring acyl groups cellular_component
YDR403W YDR403W DIT1 hom Verified 0.645920201010202 0.259165518129493 no 1247 0.246374611713616 813 NA FT CELL WALL ORG/BIOGENESIS Sporulation-specific enzyme required for spore wall maturation, involved in the production of a soluble LL-dityrosine-containing precursor of the spore wall; transcripts accumulate at the time of prospore enclosure ascospore wall assembly catalytic activity cellular_component
YDL179W YDL179W PCL9 hom Verified 0.645827235265395 0.259195623877782 no 1248 0.267093486360541 900 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION SITE OF POLARIZED GROWTH Cyclin, forms a functional kinase complex with Pho85p cyclin-dependent kinase (Cdk), expressed in late M/early G1 phase, activated by Swi5p regulation of establishment or maintenance of cell polarity|regulation of transcription involved in G1/S phase of mitotic cell cycle cyclin-dependent protein kinase regulator activity cyclin-dependent protein kinase holoenzyme complex|incipient cellular bud site|cellular bud neck
YER109C YER109C FLO8 hom Verified 0.64456497210333 0.259604570226654 no 1249 0.23933600376432 789 NA FT TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM NUCLEUS Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this gene biofilm formation|Unknown|positive regulation of starch catabolic process by positive regulation of transcription from RNA polymerase II promoter|positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus|cytoplasm
YOR339C YOR339C UBC11 hom Verified 0.644323649956519 0.25968279136951 no 1250 0.249021555990209 837 NA Ubiquitin-conjugating enzyme most similar in sequence to Xenopus ubiquitin-conjugating enzyme E2-C, but not a true functional homolog of this E2; unlike E2-C, not required for the degradation of mitotic cyclin Clb2 protein polyubiquitination|protein monoubiquitination ubiquitin-protein ligase activity cytoplasm
YBL038W YBL038W MRPL16 hom Verified 0.644077445856446 0.259762607463197 no 1251 0.284469718068577 967 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome|peptidyltransferase activity mitochondrion|mitochondrial large ribosomal subunit
YPL214C YPL214C THI6 hom Verified 0.643801571722971 0.259852057224639 no 1252 0.228739978386652 801 NA Bifunctional enzyme with thiamine-phosphate pyrophosphorylase and 4-methyl-5-beta-hydroxyethylthiazole kinase activities, required for thiamine biosynthesis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern thiamine biosynthetic process hydroxyethylthiazole kinase activity|thiamine-phosphate diphosphorylase activity cytosol|cytoplasm
YLR250W YLR250W SSP120 hom Verified 0.643478179030445 0.259956934689858 no 1253 0.260975237699263 870 NA Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern biological_process molecular_function cytoplasm
YBR262C YBR262C AIM5 hom Verified 0.643411192051348 0.259978661547915 no 1254 0.209990543078628 685 NA FT MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture cristae formation molecular_function mitochondrion|mitochondrial crista junction|integral to mitochondrial inner membrane
YER077C_p YER077C YER077C hom Uncharacterized 0.643379199724968 0.259989038413352 no 1255 0.295819164092456 1021 NA FT MITOCHONDRION Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport biological_process molecular_function mitochondrion
YGL134W YGL134W PCL10 hom Verified 0.642624989340684 0.260233732048541 no 1256 0.231948690755507 792 NA FT CELL CYCLE|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|GEN. OF PRECURSOR METABOLITES AND ENERGY Pho85p cyclin; recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate negative regulation of glycogen biosynthetic process|regulation of cyclin-dependent protein kinase activity cyclin-dependent protein kinase regulator activity cyclin-dependent protein kinase holoenzyme complex
YNR048W YNR048W YNR048W hom Verified 0.641489843134049 0.260602238902254 no 1257 0.262060176416726 907 NA Protein that interacts with phospholipid translocase (flippase) Dnf3p; YNR048W has a paralog, CDC50, that arose from the whole genome duplication response to drug phospholipid-translocating ATPase activity integral to membrane
YGR141W YGR141W VPS62 hom Verified 0.641310374241684 0.260660525157565 no 1258 0.241276199422531 827 NA FT PROTEIN LOCALIZATION|VACUOLAR TRANSPORT Vacuolar protein sorting (VPS) protein required for cytoplasm to vacuole targeting of proteins protein targeting to vacuole molecular_function cellular_component
YOR215C YOR215C AIM41 hom Verified 0.639526745574163 0.261240160141937 no 1259 0.254048597934972 852 NA FT MITOCHONDRION Putative protein of unknown function; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss biological_process molecular_function mitochondrion
YDR307W_p YDR307W PMT7 hom Uncharacterized 0.637802126191589 0.261801247672842 no 1260 0.255697744858943 870 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Putative protein mannosyltransferase similar to Pmt1p; has a potential role in protein O-glycosylation biological_process molecular_function integral to membrane|endoplasmic reticulum
YGL082W_p YGL082W YGL082W hom Uncharacterized 0.637162571213598 0.262009477450828 no 1261 0.228564492338449 778 NA FT NUCLEUS Putative protein of unknown function; predicted prenylation/proteolysis target of Afc1p and Rce1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YGL082W is not an essential gene biological_process molecular_function nucleus|plasma membrane|cytoplasm
YGR192C YGR192C TDH3 hom Verified 0.636315752218439 0.262285319947806 no 1262 0.268000912573492 893 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Glyceraldehyde-3-phosphate dehydrogenase, isozyme 3; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; TDH3 has a paralog, TDH2, that arose from the whole genome duplication gluconeogenesis|reactive oxygen species metabolic process|glycolysis|apoptotic process glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity mitochondrion|fungal-type cell wall|lipid particle|plasma membrane|cytoplasm
YDL110C YDL110C TMA17 hom Verified 0.635919355909547 0.262414493024181 no 1263 0.247728177436187 834 NA FT NUCLEUS Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion biological_process molecular_function ribosome|nucleus|cytoplasm
YNL255C YNL255C GIS2 hom Verified 0.634220909281766 0.262968331853368 no 1264 0.26117844762896 899 NA FT TRANSLATION RIBOSOME Translational activator for mRNAs with internal ribosome entry sites; associates with polysomes and binds to a specific subset of mRNAs; localizes to RNA processing bodies (P bodies) and to stress granules; may have a role in translation regulation under stress conditions; ortholog of human ZNF9/CNBP, a gene involved in myotonic dystrophy type 2 positive regulation of translation mRNA binding|translation regulator activity|single-stranded DNA binding polysomal ribosome|cytoplasm
YOR041C_d YOR041C YOR041C hom Dubious 0.634042219744349 0.263026634641587 no 1265 0.234986063812119 788 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the uncharacterized gene CUE5; deletion in cyr1 mutant results in loss of stress resistance Unknown Unknown Unknown
YMR259C YMR259C TRM732 hom Verified 0.633892028278806 0.263075644193993 no 1266 0.274041671117043 931 NA Interacts with Trm7p for 2'-O-methylation of C32 of substrate tRNAs; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; non-essential gene biological_process molecular_function cytoplasm
YHR026W YHR026W VMA16 hom Verified 0.63315204901864 0.263317177777463 no 1267 0.370967253411645 1221 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS Subunit c'' of the vacuolar ATPase, which functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domain vacuolar acidification proton-transporting ATPase activity, rotational mechanism vacuolar proton-transporting V-type ATPase, V0 domain|integral to membrane
YOR031W YOR031W CRS5 hom Verified 0.632517844015684 0.263524276100843 no 1268 0.25470929134256 874 NA Copper-binding metallothionein, required for wild-type copper resistance response to metal ion copper ion binding cytoplasm
YIL047C YIL047C SYG1 hom Verified 0.632068683303369 0.263670998862901 no 1269 0.262624271350516 926 NA FT SIGNALING MITOCHONDRION|PLASMA MEMBRANE Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency signal transduction molecular_function mitochondrion|integral to membrane|plasma membrane
YOR279C YOR279C RFM1 hom Verified 0.631484053573233 0.263862036311594 no 1270 0.298045979140788 1017 NA FT GENE SILENCING NUCLEUS DNA-binding protein required for vegetative repression of middle sporulation genes; specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p; involved in telomere maintenance chromatin silencing|chromatin silencing at silent mating-type cassette unfolded protein binding histone deacetylase complex|nucleus
YMR158C-A_p YMR158C-A YMR158C-A hom Uncharacterized 0.631045258151757 0.26400546632765 no 1271 0.241514261317351 811 NA Putative protein of unknown function, may contain a lipid attachment site; YMR158C-A is not an essential gene biological_process molecular_function cellular_component
YNL315C YNL315C ATP11 hom Verified 0.630809121721224 0.26408266919818 no 1272 0.268327395011201 920 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase mitochondrion organization|mitochondrial proton-transporting ATP synthase complex assembly unfolded protein binding mitochondrion|mitochondrial matrix
YJL157C YJL157C FAR1 hom Verified 0.630067845173817 0.264325098196322 no 1273 0.217711320439793 731 NA FT PROTEIN LOCALIZATION|CELL CYCLE|SIGNALING|CELL DIVISION NUCLEUS|SITE OF POLARIZED GROWTH Cyclin-dependent kinase inhibitor; mediates cell cycle arrest in response to pheromone; also forms a complex with Cdc24p, Ste4p, and Ste18p that may specify the direction of polarized growth during mating; potential Cdc28p substrate; relocalizes from nucleus to cytoplasm upon DNA replication stress maintenance of protein location in nucleus|pheromone-dependent signal transduction involved in conjugation with cellular fusion|cell cycle arrest in response to pheromone cyclin-dependent protein kinase inhibitor activity nucleus|mating projection tip|membrane|cytoplasm
YHL008C_p YHL008C YHL008C hom Uncharacterized 0.629861175655619 0.264392708122589 no 1274 0.259077976582035 905 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Putative protein of unknown function, may be involved in the uptake of chloride ions; does not appear to be involved in monocarboxylic acid transport; green fluorescent protein (GFP)-fusion protein localizes to the vacuole chloride transport|monocarboxylic acid transport monocarboxylic acid transmembrane transporter activity|transporter activity integral to membrane|fungal-type vacuole
YER179W YER179W DMC1 hom Verified 0.629626138278815 0.264469609014933 no 1275 0.243372333036995 818 NA FT CELL CYCLE NUCLEUS|CHROMOSOME Meiosis-specific protein required for repair of double-strand breaks and pairing between homologous chromosomes; homolog of Rad51p and the bacterial RecA protein; binds ssDNA and dsDNA, forms helical filaments; stimulated by Rdh54p meiosis|reciprocal meiotic recombination|meiotic joint molecule formation double-stranded DNA binding|single-stranded DNA binding condensed nuclear chromosome|nucleus
YIL159W YIL159W BNR1 hom Verified 0.628860163653964 0.264720304005423 no 1276 0.259724035588188 908 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNI1 barbed-end actin filament capping|actin filament bundle assembly|formin-nucleated actin cable assembly profilin binding cellular bud neck
YDR269C_d YDR269C YDR269C hom Dubious 0.628826819074352 0.264731220060269 no 1277 0.255969810960746 868 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YMR118C_p YMR118C SHH3 hom Uncharacterized 0.628612930552014 0.264801246443952 no 1278 0.245774525229981 824 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Putative mitochondrial inner membrane protein of unknown function; although similar to Sdh3p, Shh3p is not a stoichiometric subunit of either succinate dehydrogenase or of the TIM22 translocase biological_process molecular_function integral to membrane
YMR292W YMR292W GOT1 hom Verified 0.628413631729169 0.264866504683463 no 1279 0.245338768034201 842 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Homodimeric protein that is packaged into COPII vesicles and cycles between the ER and Golgi; involved in secretory transport but not directly required for aspects of transport assayed in vitro; may influence membrane composition ER to Golgi vesicle-mediated transport|Golgi to endosome transport molecular_function integral to membrane|endoplasmic reticulum|Golgi apparatus|ER to Golgi transport vesicle|Golgi membrane
YER015W YER015W FAA2 hom Verified 0.627127400944057 0.265287863540572 no 1280 0.268901820274748 928 NA FT KETONE METABOLISM|LIPID METABOLISM MITOCHONDRION Medium chain fatty acyl-CoA synthetase, activates imported fatty acids; accepts a wide range of fatty acid chain lengths with a preference for medium chains, C9:0-C13:0; localized to the peroxisome long-chain fatty acid metabolic process long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity|medium-chain fatty acid-CoA ligase activity mitochondrion|peroxisome
YGL149W_d YGL149W YGL149W hom Dubious 0.626567274293131 0.26547146282616 no 1281 0.255308113567949 847 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF INO80/YGL150C. Unknown Unknown Unknown
YLR394W YLR394W CST9 hom Verified 0.626477455528629 0.265500909773294 no 1282 0.265624608570886 894 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME SUMO E3 ligase; required for synaptonemal complex formation; localizes to synapsis initiation sites on meiotic chromosomes; potential Cdc28p substrate synaptonemal complex assembly|protein sumoylation|synapsis|reciprocal meiotic recombination SUMO ligase activity condensed nuclear chromosome|nuclear chromosome
YFR008W YFR008W FAR7 hom Verified 0.62629266086317 0.265561499638459 no 1283 0.270387582373607 954 NA FT CELL CYCLE|SIGNALING Protein involved in recovery from pheromone-induced cell cycle arrest; acts in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p; protein abundance increases in response to DNA replication stress re-entry into mitotic cell cycle after pheromone arrest molecular_function cellular_component
YPL277C_p YPL277C YPL277C hom Uncharacterized 0.625947166821491 0.265674797895923 no 1284 0.251604761087299 861 NA Putative protein of unknown function; localized to the membranes; gene expression regulated by copper levels biological_process molecular_function membrane
YGR072W YGR072W UPF3 hom Verified 0.625755439762439 0.265737681743292 no 1285 0.255314093639403 852 NA FT NUCLEUS Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|translational frameshifting|protein ubiquitination molecular_function nucleolus|nucleus|polysome|cytoplasm
YLL014W YLL014W EMC6 hom Verified 0.625025967829152 0.265977007489888 no 1286 0.30073660814789 1038 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93 protein folding in endoplasmic reticulum molecular_function ER membrane protein complex|integral to membrane|endoplasmic reticulum
YPL171C YPL171C OYE3 hom Verified 0.624733855543173 0.266072874534731 no 1287 0.265694226600701 909 NA FT OXIDATION-REDUCTION PROCESS Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with different ligand binding and catalytic properties; has potential roles in oxidative stress response and programmed cell death apoptotic process NADPH dehydrogenase activity cellular_component
YPL009C YPL009C TAE2 hom Verified 0.624273187822347 0.266224094596878 no 1288 0.265223526717981 919 NA FT TRANSLATION Protein of unknown function, involved in protein translation; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm cytoplasmic translation molecular_function ribosome|cytoplasm
YKR092C YKR092C SRP40 hom Verified 0.624084778106685 0.266285955025407 no 1289 0.262829660653513 923 NA FT NUCLEUS Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140 nucleocytoplasmic transport molecular_function nucleolus
YEL038W YEL038W UTR4 hom Verified 0.623461613564462 0.266490610008836 no 1290 0.2261829804452 763 NA FT KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Protein with sequence similarity to 2,3-diketo-5-methylthiopentyl-1-phosphate enolase-phosphatases, involved in methionine salvage; found in both the cytoplasm and nucleus L-methionine salvage from methylthioadenosine acireductone synthase activity nucleus|cytoplasm
YOL038C-A_p YOL038C-A YOL038C-A hom Uncharacterized 0.621498634877802 0.267135796205807 no 1291 0.239553363886434 790 NA Putative protein of unknown function; identified by SAGE analysis biological_process molecular_function cellular_component
YGL118C_d YGL118C YGL118C hom Dubious 0.620891071257752 0.267335648153064 no 1292 0.267513503157753 943 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YBR201W YBR201W DER1 hom Verified 0.62019054617841 0.267566172428606 no 1293 0.271357112496302 924 NA FT PROTEIN LOCALIZATION|PROTEOLYSIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM UBIQUITIN LIGASE COMPLEX Endoplasmic reticulum membrane protein, required for ER-associated protein degradation of misfolded or unassembled proteins; N- and C- termini protrude into the cytoplasm, has similarity to Dfm1p ER-associated protein catabolic process molecular_function integral to membrane|Hrd1p ubiquitin ligase ERAD-L complex|endoplasmic reticulum membrane
YER101C YER101C AST2 hom Verified 0.619271298456669 0.267868824503739 no 1294 0.273394944316034 946 NA FT PROTEIN LOCALIZATION|OXIDATION-REDUCTION PROCESS Lipid raft associated protein; overexpression restores Pma1p localization to lipid rafts which is required for targeting of Pma1p to the plasma membrane; sometimes classified in the medium-chain dehydrogenase/reductases (MDRs) superfamily; AST2 has a paralog, AST1, that arose from the whole genome duplication protein targeting to membrane molecular_function cytoplasm
YBR036C YBR036C CSG2 hom Verified 0.618997580589323 0.267958976368313 no 1295 0.295645441624317 1024 NA FF|FT LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Endoplasmic reticulum membrane protein, required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations; protein abundance increases in response to DNA replication stress cellular calcium ion homeostasis|glycosphingolipid biosynthetic process enzyme regulator activity integral to endoplasmic reticulum membrane|integral to membrane
YOR097C_p YOR097C YOR097C hom Uncharacterized 0.618959356981194 0.267971566932167 no 1296 0.286296030339501 1007 NA Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; YOR097C is not an essential gene biological_process molecular_function cellular_component
YPL086C YPL086C ELP3 hom Verified 0.615469309589459 0.26912241566812 no 1297 0.274568837431109 937 NA FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|CHROMATIN ORGANIZATION NUCLEUS Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin regulation of transcription from RNA polymerase II promoter|tRNA wobble uridine modification histone acetyltransferase activity Elongator holoenzyme complex|nucleus|cytoplasm
YBL069W YBL069W AST1 hom Verified 0.614242847225932 0.269527431681846 no 1298 0.23731062205053 823 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS GOLGI APPARATUS|PLASMA MEMBRANE Lipid raft associated protein; interacts with the plasma membrane ATPase Pma1p and has a role in its targeting to the plasma membrane by influencing its incorporation into lipid rafts; sometimes classified in the medium-chain dehydrogenase/reductases (MDRs) superfamily; AST1 has a paralog, AST2, that arose from the whole genome duplication protein targeting to membrane|protein transport into membrane raft molecular_function late endosome|membrane raft|Golgi apparatus|plasma membrane
YPL265W YPL265W DIP5 hom Verified 0.614176460239185 0.269549363440909 no 1299 0.244389205510803 864 NA FT PLASMA MEMBRANE Dicarboxylic amino acid permease; mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly; relocalizes from plasma membrane to vacuole upon DNA replication stress amino acid transport amino acid transmembrane transporter activity integral to membrane|plasma membrane
YNL199C YNL199C GCR2 hom Verified 0.613704350006983 0.269705356661976 no 1300 0.286345853470314 1005 NA FT TRANSCRIPTION FROM RNA POL II|RIBOSOME BIOGENESIS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY ENDOMEMBRANE SYSTEM|NUCLEUS Transcriptional activator of genes involved in glycolysis; interacts and functions with the DNA-binding protein Gcr1p positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter|regulation of glycolysis by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II activating transcription factor binding|RNA polymerase II transcription factor binding transcription factor activity nuclear envelope|nucleus
YBR133C YBR133C HSL7 hom Verified 0.613605668828618 0.269737968307985 no 1301 0.283207003109146 997 NA FT CELL CYCLE|CHROMATIN ORGANIZATION|CELL DIVISION SITE OF POLARIZED GROWTH Protein arginine N-methyltransferase; exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p; relocalizes away from bud neck upon DNA replication stress G2/M transition of mitotic cell cycle|regulation of cell cycle protein-arginine omega-N symmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity cellular bud neck
YGR001C_p YGR001C YGR001C hom Uncharacterized 0.613534170841331 0.269761597827159 no 1302 0.240817396929995 810 NA Putative protein of unknown function with similarity to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiae biological_process methyltransferase activity cytoplasm
YJR059W YJR059W PTK2 hom Verified 0.611244887251727 0.270518735472775 no 1303 0.307619197964147 1054 NA FF|FT CELL CYCLE|ION HOMEOSTASIS|PROTEIN PHOSPHORYLATION|ION HOMEOSTASIS NUCLEUS|PLASMA MEMBRANE Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake protein phosphorylation|cellular ion homeostasis|polyamine transport|G1/S transition of mitotic cell cycle|regulation of cell size protein kinase activity nucleus|plasma membrane|cytoplasm
YIR017C YIR017C MET28 hom Verified 0.609394412458515 0.271131520307059 no 1304 0.297773690024297 1011 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Basic leucine zipper (bZIP) transcriptional activator in the Cbf1p-Met4p-Met28p complex, participates in the regulation of sulfur metabolism regulation of transcription from RNA polymerase II promoter|regulation of sulfur amino acid metabolic process|Unknown RNA polymerase II activating transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YPL263C YPL263C KEL3 hom Verified 0.60758275597521 0.271732120268888 no 1305 0.244224710031898 822 NA Cytoplasmic protein of unknown function biological_process molecular_function cytoplasm
YKR049C YKR049C FMP46 hom Verified 0.607100439429427 0.271892129288307 no 1306 0.254016020088389 865 NA FT OXIDATION-REDUCTION PROCESS MITOCHONDRION Putative redox protein containing a thioredoxin fold; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process oxidoreductase activity mitochondrion
YGL067W YGL067W NPY1 hom Verified 0.606761949875948 0.272004451536599 no 1307 0.219264683825847 706 NA FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes; nudix hydrolase family member NADH metabolic process NAD+ diphosphatase activity peroxisome|cytoplasm
YHR110W YHR110W ERP5 hom Verified 0.606562128768908 0.272070769748729 no 1308 0.250132681943837 860 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport vesicle-mediated transport molecular_function integral to membrane
YIL084C YIL084C SDS3 hom Verified 0.604661611373707 0.272701930094661 no 1309 0.285117797371724 1006 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Component of the Rpd3p/Sin3p deacetylase complex required for its structural integrity and catalytic activity, involved in transcriptional silencing and required for sporulation; cells defective in SDS3 display pleiotropic phenotypes positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of chromatin silencing at telomere|chromatin silencing|negative regulation of chromatin silencing at rDNA|positive regulation of transcription from RNA polymerase II promoter|histone deacetylation histone deacetylase activity Rpd3L-Expanded complex|Rpd3L complex
YPL072W YPL072W UBP16 hom Verified 0.604288570041843 0.272825902080356 no 1310 0.249385854593586 851 NA FT PROTEOLYSIS MITOCHONDRION Deubiquitinating enzyme anchored to the outer mitochondrial membrane, probably not important for general mitochondrial functioning, but may perform a more specialized function at mitochondria protein deubiquitination ubiquitin-specific protease activity mitochondrial outer membrane|cytoplasm
YLR434C_d YLR434C YLR434C hom Dubious 0.603815182347746 0.272983262183306 no 1311 0.291221567734921 979 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TSR2/YLR435W Unknown Unknown Unknown
YHR025W YHR025W THR1 hom Verified 0.603723742818059 0.273013663033067 no 1312 0.293994532848258 1009 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway threonine biosynthetic process|methionine metabolic process|isoleucine metabolic process|homoserine metabolic process homoserine kinase activity cellular_component
YLR371W YLR371W ROM2 hom Verified 0.603678653015365 0.273028654632631 no 1313 0.36490135228861 1211 NA FF|FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|CELL WALL ORG/BIOGENESIS|NUCLEOTIDE METABOLISM SITE OF POLARIZED GROWTH GDP/GTP exchange factor (GEF) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEF; Rom2p localization to the bud surface is dependent on Ack1p regulation of fungal-type cell wall organization|positive regulation of endocytosis|establishment of cell polarity|small GTPase mediated signal transduction|negative regulation of cAMP-mediated signaling|activation of Rho GTPase activity phosphatidylinositol-4,5-bisphosphate binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity incipient cellular bud site|mating projection tip|cellular bud tip
YNL213C YNL213C RRG9 hom Verified 0.602454002107432 0.273435986413008 no 1314 0.286840576041579 989 NA FT MITOCHONDRION ORGANIZATION MITOCHONDRION Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies mitochondrion organization|mitochondrial genome maintenance molecular_function mitochondrion
YKL063C_p YKL063C YKL063C hom Uncharacterized 0.601763174528243 0.273665895589722 no 1315 0.247386986325594 842 NA FT GOLGI APPARATUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi biological_process molecular_function Golgi apparatus
YOR085W YOR085W OST3 hom Verified 0.60093826302242 0.273940553461396 no 1316 0.270639757301931 924 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins protein glycosylation|protein complex assembly|protein O-linked mannosylation|protein N-linked glycosylation dolichyl-diphosphooligosaccharide-protein glycotransferase activity oligosaccharyltransferase complex|integral to membrane
YKR041W YKR041W YKR041W hom Verified 0.600555032522497 0.274068198060309 no 1317 0.256597618042571 844 NA FT NUCLEUS|CYTOSKELETON Protein of unknown function; localizes to the mitotic spindle; overexpression of YKR041W affects endocytic protein trafficking biological_process molecular_function nucleus|mitotic spindle|cytoplasm
YFR054C_d YFR054C YFR054C hom Dubious 0.60035251574973 0.274135663253595 no 1318 0.246510376347545 858 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YKL115C_d YKL115C YKL115C hom Dubious 0.600288067743459 0.274157134787099 no 1319 0.264387554869503 932 NA Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1 Unknown Unknown Unknown
YMR164C YMR164C MSS11 hom Verified 0.599747423479059 0.2743372888378 no 1320 0.271494974509691 929 NA FT TRANSCRIPTION FROM RNA POL II|CARBOHYDRATE METABOLISM NUCLEUS Transcription factor involved in regulation of invasive growth and starch degradation; controls the activation of FLO11 and STA2 in response to nutritional signals biofilm formation|Unknown|positive regulation of starch catabolic process by positive regulation of transcription from RNA polymerase II promoter|positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YFL033C YFL033C RIM15 hom Verified 0.599664473043638 0.274364934839686 no 1321 0.266383492045197 894 NA FT CELL CYCLE|SIGNALING|PROTEIN PHOSPHORYLATION|RESPONSE TO OXIDATIVE STRESS NUCLEUS Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase protein phosphorylation|age-dependent response to oxidative stress involved in chronological cell aging|response to stress|regulation of meiosis protein serine/threonine kinase activity|protein kinase activity nucleus|cytoplasm
YGR097W YGR097W ASK10 hom Verified 0.598870645904056 0.274629573771448 no 1322 0.279715776378981 972 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO OXIDATIVE STRESS NUCLEUS RNA POL II, HOLOENZYME Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication cellular protein catabolic process|cellular response to oxidative stress|positive regulation of transcription from RNA polymerase II promoter|positive regulation of glycerol transport molecular_function DNA-directed RNA polymerase II, holoenzyme|cytoplasm
YNL303W_d YNL303W YNL303W hom Dubious 0.598771982443133 0.274662474100453 no 1323 0.260784232579205 882 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YER099C YER099C PRS2 hom Verified 0.598488819224133 0.274756908533474 no 1324 0.257840886486572 888 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS2 has a paralog, PRS4, that arose from the whole genome duplication fungal-type cell wall organization|5-phosphoribose 1-diphosphate biosynthetic process ribose phosphate diphosphokinase activity cytoplasm
YLR067C YLR067C PET309 hom Verified 0.595487156104791 0.275758941000783 no 1325 0.281685696205087 962 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION|OXIDATION-REDUCTION PROCESS|MITOCHONDRION ORGANIZATION|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Specific translational activator for the COX1 mRNA, also influences stability of intron-containing COX1 primary transcripts; localizes to the mitochondrial inner membrane; contains seven pentatricopeptide repeats (PPRs) positive regulation of mitochondrial translational initiation|RNA metabolic process|mitochondrial respiratory chain complex IV biogenesis|aerobic respiration translation regulator activity extrinsic to mitochondrial inner membrane|mitochondrion|integral to membrane|mitochondrial inner membrane
YDR073W YDR073W SNF11 hom Verified 0.595382574769361 0.275793885295887 no 1326 0.255554897032811 856 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS RSC COMPLEX Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p; relocates to the cytosol under hypoxic conditions positive regulation of transcription from RNA polymerase II promoter molecular_function SWI/SNF complex
YER116C YER116C SLX8 hom Verified 0.595204356726858 0.275853439212827 no 1327 0.237120212298651 807 NA FT RESPONSE TO DNA DAMAGE NUCLEUS UBIQUITIN LIGASE COMPLEX Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex; stimulated by prior attachment of SUMO to the substrate; contains a C-terminal RING domain; forms nuclear foci upon DNA replication stress protein sumoylation|telomere maintenance|response to DNA damage stimulus|protein ubiquitination ubiquitin-protein ligase activity ubiquitin ligase complex|nucleus
YNR034W YNR034W SOL1 hom Verified 0.594140734488744 0.27620899397696 no 1328 0.22849954260158 791 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|RNA LOCALIZATION|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS NUCLEUS Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL1 has a paralog, SOL2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress tRNA export from nucleus molecular_function|6-phosphogluconolactonase activity nucleus|cytoplasm
YKL171W YKL171W NNK1 hom Verified 0.593644091633257 0.276375092068735 no 1329 0.247438947964103 837 NA FT PROTEOLYSIS|PROTEIN PHOSPHORYLATION Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm proteolysis|protein phosphorylation protein kinase activity cytoplasm
YGR093W_p YGR093W YGR093W hom Uncharacterized 0.593367894182181 0.27646748521445 no 1330 0.2693809237187 944 NA FT NUCLEUS Putative protein of unconfirmed function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus biological_process molecular_function nucleus
YER073W YER073W ALD5 hom Verified 0.593176833981949 0.276531407239353 no 1331 0.282397577691621 1001 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION Mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed acetate biosynthetic process aldehyde dehydrogenase [NAD(P)+] activity mitochondrion
YDR072C YDR072C IPT1 hom Verified 0.592304501980429 0.276823350883348 no 1332 0.275812869831123 962 NA FT LIPID METABOLISM Inositolphosphotransferase, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin mannosyl diphosphorylinositol ceramide metabolic process|sphingolipid biosynthetic process transferase activity, transferring phosphorus-containing groups integral to membrane
YMR058W YMR058W FET3 hom Verified 0.592125799737222 0.276883175848332 no 1333 0.291787801581941 980 NA FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS PLASMA MEMBRANE Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress iron assimilation by reduction and transport|high-affinity iron ion transport|response to copper ion ferroxidase activity|iron ion transmembrane transporter activity integral to membrane|high affinity iron permease complex|plasma membrane
YDR333C YDR333C RQC1 hom Verified 0.589062574597719 0.277909648991181 no 1334 0.262264312426742 878 NA Component of the ribosome quality control complex (RQC); RQC (Rqc1p-Ltn1p-Tae2p-Cdc48p-Npl4p-Ufd1p), is a ribosome-bound complex required for the degradation of polypeptides arising from stalled translation; required along with Ltn1p for recruitment of the Cdc48p-Npl4p-Ufd1p AAA ATPase complex to the RQC biological_process molecular_function cytoplasm
YHR076W YHR076W PTC7 hom Verified 0.587995792075772 0.278267558628397 no 1335 0.292950741016471 975 NA FT ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION Type 2C protein phosphatase (PP2C); alternatively spliced to create two mRNA isoforms; protein from spliced form localizes to the mitochondria while the one from the unspliced form is localized to the nuclear envelope biological_process protein serine/threonine phosphatase activity nuclear envelope|mitochondrion
YNL054W YNL054W VAC7 hom Verified 0.587437891179581 0.278454825974947 no 1336 0.224015447117703 782 NA FT LIPID METABOLISM Integral vacuolar membrane protein involved in vacuole inheritance and morphology; activates Fab1p kinase activity under basal conditions and also after hyperosmotic shock positive regulation of phosphatidylinositol biosynthetic process|positive regulation of kinase activity molecular_function fungal-type vacuole membrane|integral to membrane|PAS complex|vacuolar membrane|cytoplasm
YHL015W-A_p YHL015W-A YHL015W-A hom Uncharacterized 0.587433959388034 0.278456145954399 no 1337 0.263988016114559 907 NA Putative protein of unknown function biological_process molecular_function cellular_component
YEL042W YEL042W GDA1 hom Verified 0.586429854222589 0.278793343500517 no 1338 0.275648304034778 943 NA FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate protein glycosylation guanosine-diphosphatase activity|uridine-diphosphatase activity Golgi apparatus
YNL066W YNL066W SUN4 hom Verified 0.586411032289422 0.278799666159509 no 1339 0.297589910968008 985 NA FT CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|MITOCHONDRION ORGANIZATION MITOCHONDRION Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family mitochondrion organization glucosidase activity fungal-type cell wall|mitochondrial matrix
YOL141W YOL141W PPM2 hom Verified 0.586377386936382 0.278810968471795 no 1340 0.237723161641065 797 NA FT RNA PROCESSING MITOCHONDRION AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p tRNA methylation|wybutosine biosynthetic process tRNA methyltransferase activity mitochondrion|cytoplasm
YPL205C_d YPL205C YPL205C hom Dubious 0.586220597941366 0.278863640741867 no 1341 0.254425098548135 903 NA Hypothetical protein; deletion of locus affects telomere length Unknown Unknown Unknown
YGR031W YGR031W IMO32 hom Verified 0.586209098232371 0.278867504186869 no 1342 0.271658068508691 941 NA FT MITOCHONDRION Conserved mitochondrial protein of unknown function; processed by both mitochondrial processing peptidase and mitochondrial octapeptidyl aminopeptidase; gene contains the nested antisense gene NAG1 biological_process molecular_function mitochondrion
YHR153C YHR153C SPO16 hom Verified 0.584734777576525 0.279363032901349 no 1343 0.243272352799641 860 NA FT CELL CYCLE NUCLEUS|CHROMOSOME Meiosis-specific protein involved in synaptonemal complex assembly; implicated in regulation of crossover formation; required for sporulation synaptonemal complex assembly|ascospore formation|regulation of reciprocal meiotic recombination molecular_function condensed nuclear chromosome
YPL224C YPL224C MMT2 hom Verified 0.584598997226814 0.279408691058778 no 1344 0.266349352207281 890 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt1p cellular iron ion homeostasis molecular_function mitochondrion|integral to membrane
YPL257W_p YPL257W YPL257W hom Uncharacterized 0.584340854158608 0.279495505490949 no 1345 0.26811173232897 928 NA FT CELL CYCLE Putative protein of unknown function; homozygous diploid deletion strain exhibits low budding index; physically interacts with Hsp82p; YPL257W is not an essential gene biological_process molecular_function integral to membrane
YHR014W YHR014W SPO13 hom Verified 0.583254812257322 0.279860888653089 no 1346 0.249347909265835 854 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Meiosis-specific protein, involved in maintaining sister chromatid cohesion during meiosis I as well as promoting proper attachment of kinetochores to the spindle during meiosis I and meiosis II protein localization to chromosome, centromeric region|meiotic sister chromatid cohesion|positive regulation of sister chromatid cohesion molecular_function nucleus|condensed nuclear chromosome, centromeric region
YBR296C YBR296C PHO89 hom Verified 0.583211242728197 0.279875551826162 no 1347 0.289224929555036 995 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p; mutations in related human transporter genes hPit1 and hPit2 are associated with hyperphosphatemia-induced calcification of vascular tissue and familial idiopathic basal ganglia calcification phosphate ion transport|transmembrane transport sodium:inorganic phosphate symporter activity integral to membrane|plasma membrane
YIL006W YIL006W YIA6 hom Verified 0.583092246067465 0.279915601635766 no 1348 0.292783430421071 1007 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Mitochondrial NAD+ transporter, involved in the transport of NAD+ into the mitochondria (see also YEA6); member of the mitochondrial carrier subfamily; disputed role as a pyruvate transporter; has putative mouse and human orthologs transport|mitochondrial pyruvate transport|NAD transmembrane transport pyruvate secondary active transmembrane transporter activity|transporter activity|NAD transporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YKL094W YKL094W YJU3 hom Verified 0.58265510863143 0.280062749541773 no 1349 0.277487867059577 970 NA FT LIPID METABOLISM ENDOPLASMIC RETICULUM|MITOCHONDRION Monoglyceride lipase (MGL), functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family triglyceride metabolic process serine hydrolase activity|acylglycerol lipase activity mitochondrial outer membrane|lipid particle|plasma membrane|membrane|cytoplasm
YML009C YML009C MRPL39 hom Verified 0.579715673464252 0.281053186007924 no 1350 0.249622834314036 857 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YJR061W_p YJR061W YJR061W hom Uncharacterized 0.579585523431527 0.281097078880064 no 1351 0.286997831620874 965 NA Putative protein of unknown function; non-essential gene; transcription repressed by Rm101p; YJR061W has a paralog, MNN4, that arose from the whole genome duplication biological_process molecular_function cellular_component
YDR312W YDR312W SSF2 hom Verified 0.578376961019624 0.281504822514454 no 1352 0.245310122997043 828 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS NUCLEUS Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication conjugation with cellular fusion|ribosomal large subunit assembly rRNA binding nucleolus
YJL213W YJL213W YJL213W hom Verified 0.576436102740758 0.282160223851723 no 1353 0.270959698052106 906 NA Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p biological_process molecular_function ribosome
YER076C_p YER076C YER076C hom Uncharacterized 0.57623439127057 0.282228381175513 no 1354 0.278634721818125 935 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; analysis of HA-tagged protein suggests a membrane localization biological_process molecular_function mitochondrion
YDR122W YDR122W KIN1 hom Verified 0.575915116300917 0.282336278827208 no 1355 0.256150377531705 862 NA FT VESICLE-MEDIATED TRANSPORT|PROTEIN PHOSPHORYLATION PLASMA MEMBRANE Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p protein autophosphorylation|exocytosis|protein phosphorylation protein serine/threonine kinase activity|protein kinase activity internal side of plasma membrane|plasma membrane
YMR017W YMR017W SPO20 hom Verified 0.575706330855256 0.282406847733013 no 1356 0.254265681535143 887 NA FT PLASMA MEMBRANE Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog ascospore-type prospore assembly SNAP receptor activity SNARE complex|prospore membrane
YMR251W-A YMR251W-A HOR7 hom Verified 0.574808945246766 0.282710258157676 no 1357 0.265002380018722 913 NA FT ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Protein of unknown function; overexpression suppresses Ca2+ sensitivity of mutants lacking inositol phosphorylceramide mannosyltransferases Csg1p and Csh1p; transcription is induced under hyperosmotic stress and repressed by alpha factor; HOR7 has a paralog, DDR2, that arose from the whole genome duplication plasma membrane organization molecular_function endoplasmic reticulum|plasma membrane
YLR053C_p YLR053C YLR053C hom Uncharacterized 0.573387628992088 0.283191132334814 no 1358 0.259887796069449 877 NA Putative protein of unknown function biological_process molecular_function cellular_component
YNL076W YNL076W MKS1 hom Verified 0.573111220855445 0.2832846951043 no 1359 0.27585322385991 924 NA FT TRANSCRIPTION FROM RNA POL II|SIGNALING NUCLEUS Pleiotropic negative transcriptional regulator involved in Ras-CAMP and lysine biosynthetic pathways and nitrogen regulation; involved in retrograde (RTG) mitochondria-to-nucleus signaling regulation of nitrogen utilization|negative regulation of transcription from RNA polymerase II promoter|Unknown|mitochondria-nucleus signaling pathway molecular_function cytoplasm
YPL245W_p YPL245W YPL245W hom Uncharacterized 0.573096918919996 0.283289536641161 no 1360 0.272173944112213 925 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm biological_process molecular_function nucleus|cytoplasm
YCL001W YCL001W RER1 hom Verified 0.57289200464493 0.283358909233072 no 1361 0.272550462496217 918 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Protein involved in retention of membrane proteins, including Sec12p, in the ER; localized to Golgi; functions as a retrieval receptor in returning membrane proteins to the ER protein retention in ER lumen|retrograde vesicle-mediated transport, Golgi to ER|ER to Golgi vesicle-mediated transport molecular_function COPI-coated vesicle|integral to membrane|ER to Golgi transport vesicle
YHR071W YHR071W PCL5 hom Verified 0.572412658003411 0.28352122118735 no 1362 0.24611072894239 879 NA FT CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS NUCLEUS Cyclin, interacts with and phosphorylated by Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity negative regulation of sequence-specific DNA binding transcription factor activity|regulation of protein stability|negative regulation of macroautophagy cyclin-dependent protein kinase regulator activity cyclin-dependent protein kinase holoenzyme complex|nucleus
YJL024C YJL024C APS3 hom Verified 0.572325222633259 0.283550832552881 no 1363 0.299020441285384 1035 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress Golgi to vacuole transport|vesicle-mediated transport molecular_function AP-3 adaptor complex
YJL197W YJL197W UBP12 hom Verified 0.571661284330265 0.283775734055767 no 1364 0.27605292196691 962 NA FT PROTEOLYSIS NUCLEUS Ubiquitin-specific protease; cleaves ubiquitin from ubiquitinated proteins; present in the nucleus and cytoplasm biological_process ubiquitin-specific protease activity nucleus|cytoplasm
YNR021W_p YNR021W YNR021W hom Uncharacterized 0.571002163441892 0.283999088164835 no 1365 0.274382115348583 918 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNR021W is not an essential gene biological_process molecular_function endoplasmic reticulum
YDR131C_p YDR131C YDR131C hom Uncharacterized 0.570531269645159 0.284158709877839 no 1366 0.253793035379528 860 NA FT PROTEOLYSIS F-box protein, substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity|protein binding, bridging SCF ubiquitin ligase complex
YCR073C YCR073C SSK22 hom Verified 0.569563324996908 0.284486954583456 no 1367 0.265315727766157 910 NA FT SIGNALING|PROTEIN PHOSPHORYLATION MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; functionally redundant with, and homologous to, Ssk2p; interacts with and is activated by Ssk1p; phosphorylates Pbs2p MAPK cascade involved in osmosensory signaling pathway|protein phosphorylation protein kinase activity|MAP kinase kinase kinase activity cellular_component
YCR001W_d YCR001W YCR001W hom Dubious 0.569266286631209 0.284587721103865 no 1368 0.258856223800681 875 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR001W is not an essential gene Unknown Unknown Unknown
YDR110W YDR110W FOB1 hom Verified 0.569199630768519 0.284610335606074 no 1369 0.278351464374498 933 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CHROMATIN ORGANIZATION|CHROMOSOME SEGREGATION|GENE SILENCING NUCLEUS|CHROMOSOME Nucleolar protein that binds the rDNA replication fork barrier (RFB) site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to RFB and rDNA repeat segregation; related to retroviral integrases extrachromosomal circular DNA accumulation involved in cell aging|negative regulation of DNA replication|rDNA condensation|chromatin silencing at rDNA|replicative cell aging|protein localization to nucleolar rDNA repeats|DNA recombination rDNA spacer replication fork barrier binding nucleolus|rDNA heterochromatin
YOL002C YOL002C IZH2 hom Verified 0.569004000675388 0.284676712474155 no 1370 0.2829714437137 974 NA FT KETONE METABOLISM|LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc response to zinc ion|cellular zinc ion homeostasis|response to toxin|cellular lipid metabolic process protein binding|metal ion binding integral to membrane|plasma membrane|membrane
YDL216C YDL216C RRI1 hom Verified 0.568616426796052 0.284808237273223 no 1371 0.288027897904914 1018 NA FT SIGNALING|PROTEOLYSIS NUCLEUS Catalytic subunit of the COP9 signalosome (CSN) complex that acts as an isopeptidase in cleaving the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; metalloendopeptidase involved in the adaptation to pheromone signaling adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|cullin deneddylation metalloendopeptidase activity signalosome
YLR079W YLR079W SIC1 hom Verified 0.567896890749288 0.28505249166267 no 1372 0.295833577604362 986 NA FT CELL CYCLE|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS NUCLEUS Cyclin-dependent kinase inhibitor (CKI); inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1 regulation of cyclin-dependent protein kinase activity|negative regulation of macroautophagy|G1/S transition of mitotic cell cycle cyclin-dependent protein kinase inhibitor activity nucleus|cytoplasm
YDL009C_p YDL009C YDL009C hom Uncharacterized 0.567535887008717 0.285175075947643 no 1373 0.282586437947239 956 NA Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the verified ORF YDL010W; YDL009C is not an essential gene biological_process molecular_function cellular_component
YJL175W_d YJL175W YJL175W hom Dubious 0.567454105872818 0.285202849460334 no 1374 0.276704262950342 909 NA Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor Unknown Unknown Unknown
YOL099C_d YOL099C YOL099C hom Dubious 0.567435822182385 0.285209058920749 no 1375 0.250116465864571 876 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PKH2/YOL100W; may interact with ribosomes Unknown Unknown Unknown
YLR149C YLR149C YLR149C hom Verified 0.564453159938602 0.286222884526013 no 1376 0.308019610139405 1042 NA Protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene; protein abundance increases in response to DNA replication stress biological_process molecular_function cellular_component
YNR058W YNR058W BIO3 hom Verified 0.563508596916826 0.286544303869172 no 1377 0.296844056393705 1018 NA FT KETONE METABOLISM|COFACTOR METABOLISM 7,8-diamino-pelargonic acid aminotransferase (DAPA), catalyzes the second step in the biotin biosynthesis pathway; BIO3 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis biotin biosynthetic process adenosylmethionine-8-amino-7-oxononanoate transaminase activity cytoplasm
YDR400W YDR400W URH1 hom Verified 0.563145332237545 0.286667962468978 no 1378 0.275731509711436 925 NA FT NUCLEOTIDE METABOLISM|COFACTOR METABOLISM NUCLEUS Uridine nucleosidase (uridine-cytidine N-ribohydrolase), cleaves N-glycosidic bonds in nucleosides; involved in the pyrimidine salvage and nicotinamide riboside salvage pathways pyrimidine-containing compound salvage|NAD biosynthesis via nicotinamide riboside salvage pathway|pyrimidine nucleoside catabolic process|nicotinate nucleotide salvage ribosylpyrimidine nucleosidase activity|nicotinic acid riboside hydrolase activity|nicotinamide riboside hydrolase activity|uridine nucleosidase activity nucleus|cytoplasm
YOR306C YOR306C MCH5 hom Verified 0.561945726031911 0.287076498988583 no 1379 0.272641010519357 905 NA FT PLASMA MEMBRANE Plasma membrane riboflavin transporter; facilitates the uptake of vitamin B2; required for FAD-dependent processes; sequence similarity to mammalian monocarboxylate permeases, however mutants are not deficient in monocarboxylate transport riboflavin transport monocarboxylic acid transmembrane transporter activity|riboflavin transporter activity integral to membrane|plasma membrane
YOR315W YOR315W SFG1 hom Verified 0.561267907791171 0.287307457829266 no 1380 0.281291520763377 975 NA FT CELL CYCLE NUCLEUS Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate mitotic cell cycle|pseudohyphal growth molecular_function nucleus|cytoplasm
YNL212W YNL212W VID27 hom Verified 0.560893832410328 0.28743495739028 no 1381 0.285670583899755 952 NA Cytoplasmic protein of unknown function; possibly involved in vacuolar protein degradation; not essential for proteasome-dependent degradation of fructose-1,6-bisphosphatase (FBPase); null mutants exhibit normal growth biological_process molecular_function cytoplasm
YLR061W YLR061W RPL22A hom Verified 0.559923767959015 0.287765718020486 no 1382 0.285879193772498 969 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YOR165W YOR165W SEY1 hom Verified 0.557381385450662 0.288633440419394 no 1383 0.295464536798117 1010 NA FT MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Dynamin-like GTPase that mediates homotypic ER fusion; has a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; functional ortholog of the human atlastin ATL1, defects in which cause a form of the human disease hereditary spastic paraplegia; homolog of Arabidopsis RHD3 cellular membrane organization|endoplasmic reticulum organization|endoplasmic reticulum membrane fusion|endoplasmic reticulum inheritance GTPase activity integral to membrane|endoplasmic reticulum|cortical endoplasmic reticulum|cytoplasm
YNL146W_p YNL146W YNL146W hom Uncharacterized 0.555116500990081 0.289407488430571 no 1384 0.29568249948668 1022 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNL146W is not an essential gene biological_process molecular_function endoplasmic reticulum
YER174C YER174C GRX4 hom Verified 0.554120422337941 0.28974821722672 no 1385 0.290548830415672 988 NA FT ION HOMEOSTASIS|CYTOSKELETON ORGANIZATION|ION HOMEOSTASIS|RESPONSE TO OXIDATIVE STRESS NUCLEUS Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx3p and Grx5p; protects cells from oxidative damage; mutant has increased aneuploidy tolerance; transcription is regulated by Yap5 cellular iron ion homeostasis|cellular response to oxidative stress|actin cytoskeleton organization disulfide oxidoreductase activity nucleus
YGL227W YGL227W VID30 hom Verified 0.553442109339437 0.289980355555664 no 1386 0.291334150898534 973 NA FT KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS NUCLEUS Central component of GID Complex, involved in FBPase degradation; interacts strongly with Gid8p to serve as a scaffold for other GID Complex subunits; contains SPRY domain and 3 domains that are also found in Gid8p - LisH, CTLH, and CRA; required for association of Vid vesicles and actin patches in vacuole import and degradation pathway; shifts the balance of nitrogen metabolism toward glutamate production; localizes to the nucleus and the cytoplasm regulation of nitrogen utilization|negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|vacuolar protein catabolic process molecular_function nucleus|GID complex|cytoplasm
YMR172C-A_d YMR172C-A YMR172C-A hom Dubious 0.552826336561366 0.290191166292737 no 1387 0.286668867408298 984 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YNR042W_d YNR042W YNR042W hom Dubious 0.552397609028583 0.290337984195279 no 1388 0.280223887817521 939 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2 Unknown Unknown Unknown
YOL043C YOL043C NTG2 hom Verified 0.551106881229236 0.290780204273335 no 1389 0.262392317327712 876 NA FT RESPONSE TO DNA DAMAGE NUCLEUS DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair, localizes to the nucleus; sumoylated; NTG2 has a paralog, NTG1, that arose from the whole genome duplication base-excision repair|base-excision repair, AP site formation oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity|DNA-(apurinic or apyrimidinic site) lyase activity nucleus
YKR044W YKR044W UIP5 hom Verified 0.550193786890419 0.291093232307025 no 1390 0.282791499624262 965 NA FT ENDOMEMBRANE SYSTEM|NUCLEUS Protein of unknown function that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates biological_process molecular_function nuclear envelope
YBR207W YBR207W FTH1 hom Verified 0.54931156185105 0.291395827105818 no 1391 0.243929032131852 869 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress endocytosis|high-affinity iron ion transport iron ion transmembrane transporter activity fungal-type vacuole membrane|integral to membrane
YMR214W YMR214W SCJ1 hom Verified 0.547631583225727 0.291972449256749 no 1392 0.303007362450615 1055 NA FT PROTEIN LOCALIZATION|PROTEOLYSIS ENDOPLASMIC RETICULUM One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins ER-associated protein catabolic process|protein folding in endoplasmic reticulum|response to unfolded protein chaperone binding endoplasmic reticulum lumen
YKL147C_d YKL147C YKL147C hom Dubious 0.547317638917914 0.292080263830902 no 1393 0.247632598047211 824 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene AVT3 Unknown Unknown Unknown
YER007C-A YER007C-A TMA20 hom Verified 0.544728078486181 0.292970275178174 no 1394 0.280492027108335 973 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|TRANSLATION Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; interacts with Tma22p; null mutant exhibits translation defects; has homology to human oncogene MCT-1; protein abundance increases in response to DNA replication stress ribosome biogenesis RNA binding ribosome|cytoplasm
YDR096W YDR096W GIS1 hom Verified 0.544584494213677 0.293019660752247 no 1395 0.286445751777983 942 NA FT TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM|CHROMATIN ORGANIZATION|RESPONSE TO NUTRIENT LEVELS NUCLEUS|MITOCHONDRION Histone demethylase and transcription factor; regulates genes during nutrient limitation; negatively regulates DPP1, PHR1; activity modulated by limited proteasome-mediated proteolysis; has JmjC and JmjN domain in N-terminal region that interact, promoting stability and proper transcriptional activity; contains two transactivating domains downstream of Jmj domains and a C-terminal DNA binding domain; GIS1 has a paralog, RPH1, that arose from the whole genome duplication negative regulation of transcription from RNA polymerase II promoter|chronological cell aging|regulation of phospholipid biosynthetic process|histone demethylation|positive regulation of transcription from RNA polymerase II promoter|maintenance of stationary phase in response to starvation RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|histone demethylase activity (H3-K36 specific) mitochondrion|nucleus
YPR078C_p YPR078C YPR078C hom Uncharacterized 0.543262368459411 0.293474585131673 no 1396 0.280475126384054 949 NA Putative protein of unknown function; possible role in DNA metabolism and/or in genome stability; expression is heat-inducible biological_process molecular_function cellular_component
YGR143W YGR143W SKN1 hom Verified 0.542101067162296 0.293874441805286 no 1397 0.314211815724312 1049 NA FT LIPID METABOLISM|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM Protein involved in sphingolipid biosynthesis; type II membrane protein with similarity to Kre6p fungal-type cell wall organization|(1->6)-beta-D-glucan biosynthetic process|sphingolipid biosynthetic process glucosidase activity integral to membrane
YKL005C YKL005C BYE1 hom Verified 0.541698716700726 0.294013036972751 no 1398 0.285976814138989 929 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Negative regulator of transcription elongation, contains a TFIIS-like domain and a PHD finger, multicopy suppressor of temperature-sensitive ess1 mutations, probably binds RNA polymerase II large subunit negative regulation of transcription from RNA polymerase II promoter methylated histone residue binding nucleus
YGR055W YGR055W MUP1 hom Verified 0.541664009430032 0.294024993786598 no 1399 0.295933046887735 978 NA FT PLASMA MEMBRANE High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake cysteine transport|sulfur amino acid transport|methionine transport L-methionine secondary active transmembrane transporter activity integral to membrane|integral to plasma membrane
YNL265C YNL265C IST1 hom Verified 0.5407008852846 0.29435688410152 no 1400 0.306876591617095 1051 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT Protein with a positive role in the multivesicular body sorting pathway; functions and forms a complex with Did2p; recruitment to endosomes is mediated by the Vps2p-Vps24p subcomplex of ESCRT-III; also interacts with Vps4p late endosome to vacuole transport via multivesicular body sorting pathway molecular_function endosome|cytoplasm
YOL058W YOL058W ARG1 hom Verified 0.540697162733434 0.294358167219426 no 1401 0.312352186319563 1062 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Arginosuccinate synthetase, catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate argininosuccinate metabolic process|arginine biosynthetic process|citrulline metabolic process argininosuccinate synthase activity cytosol
YOR292C_p YOR292C YOR292C hom Uncharacterized 0.539246698319912 0.29485832100943 no 1402 0.27144360381124 912 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YOR292C is not an essential gene biological_process molecular_function integral to membrane|fungal-type vacuole
YNL285W_d YNL285W YNL285W hom Dubious 0.538373993885154 0.295159438368364 no 1403 0.284543202653772 988 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOR073W YOR073W SGO1 hom Verified 0.537414239659238 0.295490754710735 no 1404 0.306711812709497 1050 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME|CYTOSKELETON KINETOCHORE Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability positive regulation of maintenance of meiotic sister chromatid cohesion|meiotic sister chromatid segregation|meiotic sister chromatid separation|sister chromatid biorientation|maintenance of meiotic sister chromatid cohesion|mitotic cell cycle spindle assembly checkpoint|mitotic sister chromatid segregation molecular_function condensed nuclear chromosome kinetochore|nucleus|spindle pole body|condensed nuclear chromosome, centromeric region
YOL106W_d YOL106W YOL106W hom Dubious 0.536598028380039 0.295772653159436 no 1405 0.287115389924425 945 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YJR097W YJR097W JJJ3 hom Verified 0.536394312682837 0.295843030600735 no 1406 0.304368127830155 1049 NA FT NUCLEUS Protein of unknown function, contains a CSL Zn finger and a DnaJ-domain; involved in diphthamide biosynthesis; ortholog human Dph4 peptidyl-diphthamide biosynthetic process from peptidyl-histidine ferrous iron binding nucleus|cytoplasm
YGR258C YGR258C RAD2 hom Verified 0.536303797543549 0.295874303235728 no 1407 0.264222162720124 902 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO DNA DAMAGE NUCLEUS Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein nucleotide-excision repair, DNA incision, 3'-to lesion|transcription from RNA polymerase II promoter single-stranded DNA specific endodeoxyribonuclease activity nucleotide-excision repair factor 3 complex
YMR280C YMR280C CAT8 hom Verified 0.535926414354342 0.296004704043937 no 1408 0.256538136806473 910 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS NUCLEUS Zinc cluster transcriptional activator; necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements; relative distribution to the nucleus increases upon DNA replication stress positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source|positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter|positive regulation of glyoxylate cycle by positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YDL061C YDL061C RPS29B hom Verified 0.53590917722782 0.296010660782445 no 1409 0.280437834842531 971 NA FT TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29B has a paralog, RPS29A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic small ribosomal subunit
YER177W YER177W BMH1 hom Verified 0.535866056138454 0.296025562640215 no 1410 0.292462723773612 1017 NA FT CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS 14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress glycogen metabolic process|pseudohyphal growth|signal transduction involved in filamentous growth|ascospore formation|fungal-type cell wall chitin biosynthetic process|Ras protein signal transduction|DNA damage checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle DNA replication origin binding|phosphoserine binding plasma membrane|nucleus
YDR156W YDR156W RPA14 hom Verified 0.535785642536387 0.296053353026339 no 1411 0.257696156225655 898 NA FT NUCLEUS RNA polymerase I subunit A14 transcription of nuclear large rRNA transcript from RNA polymerase I promoter|regulation of cell size molecular_function DNA-directed RNA polymerase I complex
YKL010C YKL010C UFD4 hom Verified 0.534429544130654 0.296522191536134 no 1412 0.298326953550535 1002 NA FT PROTEOLYSIS MITOCHONDRION Ubiquitin-protein ligase (E3); interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins; relative distribution to the nucleus increases upon DNA replication stress protein monoubiquitination|protein polyubiquitination ubiquitin-protein ligase activity mitochondrion|cytoplasm
YDR379W YDR379W RGA2 hom Verified 0.533760550515343 0.296753605280632 no 1413 0.281186399337601 926 NA FT SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; regulated by Pho85p and Cdc28p budding cell isotropic bud growth|pheromone-dependent signal transduction involved in conjugation with cellular fusion|actin filament organization|pseudohyphal growth|establishment of cell polarity|small GTPase mediated signal transduction|invasive growth in response to glucose limitation|budding cell apical bud growth Rho GTPase activator activity cellular bud neck split septin rings
YNR075W YNR075W COS10 hom Verified 0.532722208711656 0.297112945113481 no 1414 0.270565152322378 925 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins endocytosis molecular_function nuclear envelope|integral to membrane|endoplasmic reticulum|cytoplasm
YJL169W_d YJL169W YJL169W hom Dubious 0.532325278835329 0.297250363518703 no 1415 0.27944891523399 978 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2 Unknown Unknown Unknown
YJL078C YJL078C PRY3 hom Verified 0.531965852355469 0.297374823180409 no 1416 0.259467679222556 886 NA Cell wall-associated protein involved in export of acetylated sterols; member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); role in mating efficiency; expression of full-length transcript is daughter cell-specific; in response to alpha factor, a short transcript starting at +452 is expressed and the long form is repressed by Ste12p biological_process molecular_function fungal-type cell wall
YEL017W YEL017W GTT3 hom Verified 0.531889443119461 0.297401284698615 no 1417 0.282381270178022 978 NA FT ENDOMEMBRANE SYSTEM|NUCLEUS Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery biological_process molecular_function cellular_component
YLR015W YLR015W BRE2 hom Verified 0.530813656720162 0.297773957715461 no 1418 0.323400648070209 1079 NA FT CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Subunit of COMPASS (Set1C) complex, which methylates Lys4 of histone H3 and functions in silencing at telomeres; has a C-terminal Sdc1 Dpy-30 Interaction (SDI) domain that mediates binding to Sdc1p; similar to trithorax-group protein ASH2L histone H3-K4 methylation|telomere maintenance|histone H3-K4 trimethylation|chromatin silencing at telomere histone methyltransferase activity (H3-K4 specific) Set1C/COMPASS complex
YER107C YER107C GLE2 hom Verified 0.530427878575598 0.297907650526327 no 1419 0.344460456490834 1164 NA FF|FT PROTEIN LOCALIZATION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE RNA export factor associated with the nuclear pore complex (NPC); associates with NUP116p; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p and human RAE1 poly(A)+ mRNA export from nucleus|Unknown|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|nuclear pore distribution|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery molecular_function integral to membrane|nuclear pore|cytoplasm
YNL049C YNL049C SFB2 hom Verified 0.529881711721341 0.298096973408244 no 1420 0.284835439524853 940 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Component of the Sec23p-Sfb2p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb3p cargo loading into COPII-coated vesicle signal sequence binding COPII vesicle coat
YGL057C YGL057C GEP7 hom Verified 0.528884129061458 0.298442916162462 no 1421 0.311543145077583 1074 NA FT MITOCHONDRION Protein of unknown function; null mutant exhibits a respiratory growth defect and synthetic interactions with prohibitin (phb1) and gem1; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YDL203C YDL203C ACK1 hom Verified 0.5285489747545 0.2985591823068 no 1422 0.295424105860625 992 NA FT SIGNALING|CELL WALL ORG/BIOGENESIS MITOCHONDRION Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria fungal-type cell wall organization|positive regulation of signal transduction molecular_function mitochondrion
YOR083W YOR083W WHI5 hom Verified 0.527959545974073 0.298763707072888 no 1423 0.282245211407905 945 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE NUCLEUS Repressor of G1 transcription that binds to SCB binding factor (SBF) at SCB target promoters in early G1; phosphorylation of Whi5p by the CDK, Cln3p/Cdc28p relieves repression and promoter binding by Whi5; periodically expressed in G1 negative regulation of transcription involved in G1/S phase of mitotic cell cycle|regulation of cell size RNA polymerase II transcription factor recruiting transcription factor activity|RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription SBF transcription complex|nucleus|cytoplasm
YDL157C_p YDL157C YDL157C hom Uncharacterized 0.527709781704835 0.298850391504261 no 1424 0.256466926726719 860 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YDR282C_p YDR282C YDR282C hom Uncharacterized 0.526784942773384 0.299171470165841 no 1425 0.275346278386227 922 NA Putative protein of unknown function; localizes to the inner mitochondrial membrane with the C terminus facing the intermembrane space; ortholog of human RMND1, mutation in which is implicated in infantile encephaloneuromyopathy and defective mitochondrial translation biological_process molecular_function cellular_component
YDR338C_p YDR338C YDR338C hom Uncharacterized 0.525261456016017 0.299700723971069 no 1426 0.32295666858043 1095 NA Putative protein of unknown function, member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily transmembrane transport antiporter activity integral to membrane
YJL133W YJL133W MRS3 hom Verified 0.52518789280246 0.29972629029649 no 1427 0.281455439673936 962 NA FT RNA PROCESSING|ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION Iron transporter, mediates Fe2+ transport across inner mito membrane; mitochondrial carrier family member; active under low-iron conditions; may transport other cations; MRS3 has a paralog, MRS4, that arose from the whole genome duplication mitochondrial iron ion transport|RNA splicing iron ion transmembrane transporter activity mitochondrion|integral to membrane
YDR330W YDR330W UBX5 hom Verified 0.525068151357166 0.299767907621296 no 1428 0.278645853108471 943 NA FT PROTEOLYSIS NUCLEUS UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p proteasomal ubiquitin-dependent protein catabolic process molecular_function nucleus|cytoplasm
YGL192W YGL192W IME4 hom Verified 0.523910640657888 0.30017034676611 no 1429 0.32055366228644 1100 NA FT CELL CYCLE NUCLEUS Probable mRNA N6-adenosine methyltransferase required for entry into meiosis; transcribed in diploid cells; haploids repress IME4 transcription via production of antisense IME4 transcripts; antisense transcription is repressed in diploids meiosis|mRNA methylation mRNA (N6-adenosine)-methyltransferase activity cellular_component
YKL096C-B_p YKL096C-B YKL096C-B hom Uncharacterized 0.523795042520275 0.300210550923666 no 1430 0.314435867507004 1033 NA Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YDR444W_p YDR444W YDR444W hom Uncharacterized 0.523737277675051 0.300230642011954 no 1431 0.302793328147589 1020 NA FT LIPID METABOLISM Putative hydrolase acting on ester bonds biological_process molecular_function cytoplasm
YLR227C YLR227C ADY4 hom Verified 0.523692196507038 0.300246322035278 no 1432 0.277299423547769 926 NA FT CELL CYCLE|CELL DIVISION NUCLEUS|CYTOSKELETON Structural component of the meiotic outer plaque, which is a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane sporulation resulting in formation of a cellular spore structural molecule activity spindle pole body
YOR080W YOR080W DIA2 hom Verified 0.523418719477217 0.300341450090919 no 1433 0.308377473926845 1057 NA FT CELL CYCLE|PROTEOLYSIS NUCLEUS|CHROMOSOME UBIQUITIN LIGASE COMPLEX Origin-binding F-box protein; forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays a role in DNA replication; plays a role in transcription; required for correct assembly of RSC complex, correct RSC-mediated transcription regulation, and correct nucleosome positioning; involved in invasive and pseudohyphal growth; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|regulation of DNA replication|invasive growth in response to glucose limitation|protein ubiquitination ubiquitin-protein ligase activity|DNA replication origin binding SCF ubiquitin ligase complex|nucleus|nuclear replication fork
YGL131C YGL131C SNT2 hom Verified 0.522882707766713 0.300527939440809 no 1434 0.292049227457668 980 NA FT NUCLEUS|CHROMOSOME DNA binding protein with similarity to the S. pombe Snt2 protein; RING finger ubiquitin ligase (E3) involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p; null mutant sensitive to hydroxyurea (HU); computational analysis suggests that Snt2p is a transcription factor with a role in regulation of expression of genes encoding amine transporters; relocalizes from nucleus to cytoplasm upon DNA replication stress biological_process DNA binding nucleus|Snt2C complex|cytoplasm
YDL040C YDL040C NAT1 hom Verified 0.522275635024596 0.300739215493096 no 1435 0.284911522673843 994 NA FT MITOCHONDRION RIBOSOME Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing N-terminal protein amino acid acetylation peptide alpha-N-acetyltransferase activity mitochondrion|NatA complex|cytosolic ribosome
YDL184C YDL184C RPL41A hom Verified 0.521764419378213 0.300917182915659 no 1436 0.293934960793229 956 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L41A; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41A has a paralog, RPL41B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YNL187W YNL187W SWT21 hom Verified 0.52167793336755 0.300947295634882 no 1437 0.296218554917456 1044 NA FT RNA PROCESSING NUCLEUS Protein involved in mRNA splicing; contains a consensus nuclear export signal (NES) sequence similar to the consensus sequence recognized by Crm1p; interacts genetically with Prp40p and Tgs1p; contains WD40 repeats mRNA splicing, via spliceosome molecular_function small nuclear ribonucleoprotein complex|nucleus
YIL023C YIL023C YKE4 hom Verified 0.521596367367683 0.300975696548523 no 1438 0.271786363575523 887 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Zinc transporter; localizes to the ER; null mutant is sensitive to calcofluor white, leads to zinc accumulation in cytosol; ortholog of the mouse KE4 and member of the ZIP (ZRT, IRT-like Protein) family zinc ion transport zinc ion transmembrane transporter activity integral to membrane|endoplasmic reticulum
YNL198C_d YNL198C YNL198C hom Dubious 0.520822280863992 0.301245290110288 no 1439 0.292148499295529 981 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDL133C-A YDL133C-A RPL41B hom Verified 0.519997078782766 0.301532805570074 no 1440 0.289128979428937 1015 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YDR466W YDR466W PKH3 hom Verified 0.519159274783718 0.30182483800842 no 1441 0.344690479692183 1180 NA FF|FT SIGNALING|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant MAPK cascade involved in cell wall biogenesis|protein phosphorylation protein kinase activity cellular_component
YNL074C YNL074C MLF3 hom Verified 0.516900496607856 0.302612810473097 no 1442 0.293198082577606 1005 NA Serine-rich protein of unknown function, predicted to be palmitoylated; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide response to drug molecular_function cytoplasm
YBL070C_d YBL070C YBL070C hom Dubious 0.516181723442613 0.302863746971655 no 1443 0.310568565562057 1057 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YCL035C YCL035C GRX1 hom Verified 0.516155998706975 0.302872729661057 no 1444 0.289517756232342 966 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS NUCLEUS Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress protein glutathionylation|cellular response to oxidative stress disulfide oxidoreductase activity|glutathione transferase activity|glutathione peroxidase activity nucleus|cytoplasm
YGL100W YGL100W SEH1 hom Verified 0.515164654240539 0.303218983006474 no 1445 0.314985810512902 1100 NA FF|FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|PLASMA MEMBRANE NUCLEAR PORE Component of two distinct complexes; subunit of the Nup84 nuclear pore sub-complex (NPC) and the Seh1-associated (SEA) complex; the the NUP84 subcomplex contributes to nucleocytoplasmic transport and NPC biogenesis; the SEA complex is a coatamer-related complex that associates dynamically with the vacuole; homologous to human SEH1 nucleocytoplasmic transport structural constituent of nuclear pore fungal-type vacuole membrane|integral to membrane|nuclear pore|Seh1-associated complex|nuclear pore outer ring
YGR052W_p YGR052W FMP48 hom Uncharacterized 0.514186867290477 0.30356067429763 no 1446 0.341351677992287 1127 NA FT PROTEIN PHOSPHORYLATION MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation protein phosphorylation protein kinase activity mitochondrion
YNL050C_p YNL050C YNL050C hom Uncharacterized 0.513775417369684 0.303704508385509 no 1447 0.311349390433401 1060 NA Putative protein of unknown function; YNL050c is not an essential gene biological_process molecular_function cellular_component
YBR064W_d YBR064W YBR064W hom Dubious 0.513451347224215 0.30381781778221 no 1448 0.285991898109823 985 NA Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YBR063C Unknown Unknown Unknown
YKR046C YKR046C PET10 hom Verified 0.512383876163116 0.304191186641277 no 1449 0.299403999322791 1021 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY Protein of unknown function that co-purifies with lipid particles; expression pattern suggests a role in respiratory growth; computational analysis of large-scale protein-protein interaction data suggests a role in ATP/ADP exchange aerobic respiration molecular_function lipid particle
YMR310C_p YMR310C YMR310C hom Uncharacterized 0.511398395922728 0.304536058955699 no 1450 0.303392126896707 1023 NA FT NUCLEUS Putative S-adenosylmethionine-dependent methyltransferase; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR310C is not an essential gene biological_process S-adenosylmethionine-dependent methyltransferase activity nucleus
YDL241W_p YDL241W YDL241W hom Uncharacterized 0.511224730808242 0.304596851704809 no 1451 0.291531387037534 984 NA Putative protein of unknown function; YDL241W is not an essential gene biological_process molecular_function cellular_component
YPL249C-A YPL249C-A RPL36B hom Verified 0.510878098286744 0.304718209102495 no 1452 0.260365187398244 919 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L36B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36B has a paralog, RPL36A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome|RNA binding cytosolic large ribosomal subunit
YKR030W YKR030W GMH1 hom Verified 0.510749761258972 0.304763145848828 no 1453 0.289300973411599 1017 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Golgi membrane protein of unknown function, interacts with Gea1p and Gea2p; required for localization of Gea2p; computational analysis suggests a possible role in either cell wall synthesis or protein-vacuolar targeting transport molecular_function integral to membrane|integral to Golgi membrane
YBR021W YBR021W FUR4 hom Verified 0.508327769100952 0.305611749381347 no 1454 0.352441530168241 1220 NA FF|FT PLASMA MEMBRANE Plasma membrane localized uracil permease; expression is tightly regulated by uracil levels and environmental cues; conformational alterations induced by unfolding or substrate binding result in Rsp5p-mediated ubiquitination and degradation uracil transport|transmembrane transport uracil:cation symporter activity integral to membrane|membrane raft|plasma membrane
YNL253W YNL253W TEX1 hom Verified 0.508212550135444 0.305652145211058 no 1455 0.292308045196781 979 NA FT RNA LOCALIZATION NUCLEUS Protein involved in mRNA export, component of the transcription export (TREX) complex mRNA export from nucleus molecular_function transcription export complex
YPL057C YPL057C SUR1 hom Verified 0.507244320468704 0.305991700461357 no 1456 0.279751782359241 974 NA FT LIPID METABOLISM Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication glycosphingolipid biosynthetic process|mannosyl-inositol phosphorylceramide metabolic process|sphingolipid biosynthetic process mannosyltransferase activity|transferase activity, transferring glycosyl groups integral to membrane|intracellular
YNL235C_d YNL235C YNL235C hom Dubious 0.504697494961114 0.306885660388221 no 1457 0.329534812846405 1109 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SIN4/YNL236W, a subunit of the mediator complex Unknown Unknown Unknown
YPR200C YPR200C ARR2 hom Verified 0.504373123198907 0.306999600593616 no 1458 0.296629185502897 1021 NA Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p response to arsenic-containing substance arsenate reductase activity cellular_component
YDR525W_d YDR525W API2 hom Dubious 0.502842196154178 0.307537612020204 no 1459 0.350391928560885 1156 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 26% of ORF overlaps the dubious ORF YDR524C-A; insertion mutation in a cdc34-2 mutant background causes altered bud morphology Unknown Unknown Unknown
YGR248W YGR248W SOL4 hom Verified 0.501842861995556 0.307889030106352 no 1460 0.296385573245629 1011 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS NUCLEUS 6-phosphogluconolactonase; protein abundance increases in response to DNA replication stress; SOL4 has a paralog, SOL3, that arose from the whole genome duplication pentose-phosphate shunt, oxidative branch 6-phosphogluconolactonase activity cytosol|nucleus|cytoplasm
YDR250C_d YDR250C YDR250C hom Dubious 0.501712874974136 0.307934753294195 no 1461 0.309113697713531 1056 NA Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data Unknown Unknown Unknown
YBL045C YBL045C COR1 hom Verified 0.501387628750209 0.308049172350767 no 1462 0.318602689608936 1078 NA FT OXIDATION-REDUCTION PROCESS|PROTEOLYSIS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Core subunit of the ubiquinol-cytochrome c reductase complex (bc1 complex), which is a component of the mitochondrial inner membrane electron transport chain aerobic respiration ubiquinol-cytochrome-c reductase activity mitochondrion|integral to membrane|mitochondrial respiratory chain complex III
YGR224W YGR224W AZR1 hom Verified 0.50054700388846 0.308344983966109 no 1463 0.286770821474756 985 NA FT PLASMA MEMBRANE Plasma membrane transporter of the major facilitator superfamily, involved in resistance to azole drugs such as ketoconazole and fluconazole azole transport azole transporter activity integral to membrane|plasma membrane
YBL017C YBL017C PEP1 hom Verified 0.500097868350897 0.308503083516129 no 1464 0.2801362606877 936 NA FT PROTEIN LOCALIZATION|VACUOLAR TRANSPORT GOLGI APPARATUS Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments vacuolar transport|protein targeting to vacuole signal sequence binding integral to membrane|Golgi apparatus
YMR104C YMR104C YPK2 hom Verified 0.499882504836604 0.308578905914085 no 1465 0.268771250812245 910 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL WALL ORG/BIOGENESIS|PROTEIN PHOSPHORYLATION NUCLEUS Protein kinase with similarity to serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK; YPK2 has a paralog, YPK1, that arose from the whole genome duplication eisosome assembly|protein phosphorylation protein kinase activity nucleus|cytoplasm
YLR118C YLR118C YLR118C hom Verified 0.499771023558512 0.308618158005867 no 1466 0.293419197618516 975 NA FT KETONE METABOLISM|LIPID METABOLISM NUCLEUS Acyl-protein thioesterase responsible for depalmitoylation of Gpa1p; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS protein deacylation palmitoyl-(protein) hydrolase activity nucleus|cytoplasm
YMR304C-A_d YMR304C-A YMR304C-A hom Dubious 0.499246707631987 0.308802796775676 no 1467 0.307636779825664 1045 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SCW10 Unknown Unknown Unknown
YBR111W-A YBR111W-A SUS1 hom Verified 0.49800764088957 0.309239328319242 no 1468 0.374147193653585 1230 NA FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE|HISTONE ACETYLTRANSFERASE Component of both the SAGA histone acetylase and TREX-2 complexes; interacts with RNA polymerase II; involved in mRNA export coupled transcription activation and elongation; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP poly(A)+ mRNA export from nucleus|regulation of protein localization|nuclear retention of pre-mRNA at the site of transcription|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|histone deubiquitination|histone H3-K4 methylation|transcription elongation from RNA polymerase II promoter|histone H3-K79 methylation|positive regulation of transcription from RNA polymerase II promoter enzyme activator activity DUBm complex|nucleoplasm|transcription export complex 2|SAGA complex|nuclear pore
YLL025W YLL025W PAU17 hom Verified 0.495900239967564 0.309982398424563 no 1469 0.28268882482129 949 NA Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; YLL025W is not an essential gene biological_process molecular_function cellular_component
YMR226C YMR226C YMR226C hom Verified 0.494597399338816 0.310442169165216 no 1470 0.305313403136881 1050 NA FT OXIDATION-REDUCTION PROCESS NUCLEUS NADP(+)-dependent dehydrogenase; acts on serine, L-allo-threonine, and other 3-hydroxy acids; green fluorescent protein fusion protein localizes to the cytoplasm and nucleus; may interact with ribosomes, based on co-purification experiments metabolic process oxidoreductase activity|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor|carbonyl reductase (NADPH) activity integral to membrane|ribosome|nucleus|cytoplasm
YLR414C YLR414C PUN1 hom Verified 0.491400622071275 0.311571562176948 no 1471 0.274100270045331 905 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL WALL ORG/BIOGENESIS PLASMA MEMBRANE Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress fungal-type cell wall organization|protein oligomerization molecular_function integral to membrane|membrane raft|plasma membrane|cellular bud|cytoplasm
YFR056C_d YFR056C YFR056C hom Dubious 0.489661684193821 0.312186659654661 no 1472 0.30511269234717 1023 NA Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W Unknown Unknown Unknown
YEL011W YEL011W GLC3 hom Verified 0.486909048773114 0.313161393050412 no 1473 0.28830614755867 966 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress glycogen biosynthetic process 1,4-alpha-glucan branching enzyme activity cytoplasm
YPL194W YPL194W DDC1 hom Verified 0.485685815170049 0.313594971153547 no 1474 0.303231909968213 1052 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME DNA damage checkpoint protein; part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate; forms nuclear foci upon DNA replication stress meiosis|mitotic cell cycle G1/S transition checkpoint|intra-S DNA damage checkpoint|recombinational repair|G2/M transition checkpoint|cell cycle checkpoint molecular_function condensed nuclear chromosome|checkpoint clamp complex
YPL145C YPL145C KES1 hom Verified 0.482723611289598 0.314645997994697 no 1475 0.319394584067016 1060 NA FT VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|GOLGI APPARATUS One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication post-Golgi vesicle-mediated transport|positive regulation of phosphatase activity|maintenance of cell polarity|endocytosis|exocytosis|sterol transport phosphatidic acid binding|lipid binding|phosphatidylinositol-4,5-bisphosphate binding|oxysterol binding|sterol transporter activity|phosphatidylinositol-4-phosphate binding Golgi membrane|extrinsic to membrane|cytoplasm
YPR111W YPR111W DBF20 hom Verified 0.48213193664486 0.314856111959756 no 1476 0.290294590786521 987 NA FT CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION SITE OF POLARIZED GROWTH|CYTOSKELETON Ser/Thr kinase involved in late nuclear division, one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs cytokinesis after mitosis|protein phosphorylation|barrier septum assembly involved in cell cycle cytokinesis|regulation of mRNA catabolic process|exit from mitosis protein serine/threonine kinase activity spindle pole body|cellular bud neck|cytoplasm
YPR134W YPR134W MSS18 hom Verified 0.481716236806297 0.315003770065713 no 1477 0.321442446426662 1103 NA FT RNA PROCESSING MITOCHONDRION Nuclear encoded protein needed for efficient splicing of mitochondrial COX1 aI5beta intron; mss18 mutations block cleavage of 5' exon - intron junction; phenotype of intronless strain suggests additional functions Group I intron splicing molecular_function mitochondrion
YDR360W_d YDR360W OPI7 hom Dubious 0.480871501118419 0.31530391435785 no 1478 0.314666112116727 1056 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene VID21/YDR359C. Unknown Unknown Unknown
YLR377C YLR377C FBP1 hom Verified 0.480820948366387 0.315321880200177 no 1479 0.318399323854654 1071 NA FT CARBOHYDRATE METABOLISM Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism; undergoes either proteasome-mediated or autophagy-mediated degradation depending on growth conditions; interacts with Vid30p gluconeogenesis|reactive oxygen species metabolic process fructose 1,6-bisphosphate 1-phosphatase activity cytosol
YBR287W_p YBR287W YBR287W hom Uncharacterized 0.479691168713978 0.31572350422117 no 1480 0.291220570018965 982 NA FT ENDOPLASMIC RETICULUM Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene biological_process molecular_function integral to membrane|endoplasmic reticulum
YCR004C YCR004C YCP4 hom Verified 0.47966473935938 0.315732902168592 no 1481 0.306003370324069 997 NA FT OXIDATION-REDUCTION PROCESS MITOCHONDRION Protein of unknown function, has sequence and structural similarity to flavodoxins; predicted to be palmitoylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process electron carrier activity mitochondrion|membrane raft|plasma membrane|cytoplasm
YMR273C YMR273C ZDS1 hom Verified 0.477933433014803 0.316348792308349 no 1482 0.335590161488145 1141 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CELL WALL ORG/BIOGENESIS|RNA LOCALIZATION|GENE SILENCING ENDOMEMBRANE SYSTEM|NUCLEUS|SITE OF POLARIZED GROWTH NUCLEAR PORE Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintaining Cdc55p in the cytoplasm where it promotes mitotic entry; involved in mitotic exit through Cdc14p regulation; interacts with silencing proteins at telomeres; has a role in Bcy1p localization; implicated in mRNA nuclear export; ZDS1 has a paralog, ZDS2, that arose from the whole genome duplication mRNA export from nucleus|positive regulation of G2/M transition of mitotic cell cycle|cell shape checkpoint|chromatin silencing|establishment of cell polarity|regulation of protein localization|cell aging protein phosphatase type 2A regulator activity incipient cellular bud site|nuclear pore|cellular bud neck|cellular bud tip|cytoplasm
YOR029W_d YOR029W YOR029W hom Dubious 0.47713164407458 0.316634191305117 no 1483 0.27503890603128 927 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDL090C YDL090C RAM1 hom Verified 0.47671794634547 0.316781490876756 no 1484 0.364389855690518 1220 NA FF|FT PROTEIN PRENYLATION Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit protein farnesylation protein farnesyltransferase activity protein farnesyltransferase complex
YPL191C_p YPL191C YPL191C hom Uncharacterized 0.475675568941145 0.317152764420197 no 1485 0.311970363793005 1063 NA Putative protein of unknown function; diploid deletion strain exhibits high budding index; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm biological_process molecular_function cytoplasm
YER086W YER086W ILV1 hom Verified 0.475597368136577 0.317180625378855 no 1486 0.351476004267549 1169 NA FF|FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation threonine catabolic process|isoleucine biosynthetic process L-threonine ammonia-lyase activity mitochondrion
YBR035C YBR035C PDX3 hom Verified 0.474718114414576 0.317493952420584 no 1487 0.31330428022439 1080 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism fatty acid metabolic process pyridoxamine-phosphate oxidase activity cellular_component
YNL034W_p YNL034W YNL034W hom Uncharacterized 0.474642888399253 0.317520765714254 no 1488 0.314573173038316 1055 NA Putative protein of unknown function; YNL034W is not an essential gene biological_process molecular_function cellular_component
YDL130W YDL130W RPP1B hom Verified 0.474578170885163 0.317543834161207 no 1489 0.326214952558635 1072 NA FT TRANSLATION RIBOSOME Ribosomal protein P1 beta, component of the ribosomal stalk, which is involved in interaction of translational elongation factors with ribosome; accumulation is regulated by phosphorylation and interaction with the P2 stalk component cytoplasmic translation|translational elongation structural constituent of ribosome cytosolic large ribosomal subunit
YDR313C YDR313C PIB1 hom Verified 0.474220118549228 0.317671474104084 no 1490 0.317547493970298 1065 NA RING-type ubiquitin ligase of the endosomal and vacuolar membranes, binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain protein ubiquitination ubiquitin-protein ligase activity|phosphatidylinositol-3-phosphate binding fungal-type vacuole membrane|late endosome
YJL207C YJL207C LAA1 hom Verified 0.472940959309574 0.318127650901297 no 1491 0.321005490351293 1052 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene protein localization|retrograde transport, endosome to Golgi molecular_function AP-1 adaptor complex|ribosome|clathrin-coated vesicle
YML001W YML001W YPT7 hom Verified 0.47240026408138 0.318320557952877 no 1492 0.305379784190456 1026 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|VACUOLAR TRANSPORT MITOCHONDRION Rab family GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion; interacts with the cargo selection/retromer complex for retrograde sorting; similar to mammalian Rab7 regulation of vacuole fusion, non-autophagic|piecemeal microautophagy of nucleus|vacuole inheritance|Golgi to vacuole transport|vesicle-mediated transport|endocytosis GTPase activity mitochondrial outer membrane|fungal-type vacuole
YLR255C_d YLR255C YLR255C hom Dubious 0.472222313338008 0.318384057278035 no 1493 0.334158051293145 1110 NA Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR307C-A_p YLR307C-A YLR307C-A hom Uncharacterized 0.471903237297885 0.31849792862506 no 1494 0.302227167814976 997 NA Putative protein of unknown function biological_process molecular_function cellular_component
YOR275C YOR275C RIM20 hom Verified 0.471006631373985 0.31881799967492 no 1495 0.311442525780537 1071 NA FT ION HOMEOSTASIS|PROTEOLYSIS|ION HOMEOSTASIS NUCLEUS Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation proteolysis|response to pH|protein processing|invasive growth in response to glucose limitation|sporulation resulting in formation of a cellular spore molecular_function nucleus|cytoplasm
YPL096W YPL096W PNG1 hom Verified 0.469267414844358 0.319439251788064 no 1496 0.329133444730683 1102 NA FT RESPONSE TO DNA DAMAGE|PROTEOLYSIS NUCLEUS|MITOCHONDRION Conserved peptide N-glycanase required for deglycosylation of misfolded glycoproteins during proteasome-dependent degradation; localizes to the cytoplasm and nucleus; activity is enhanced by interaction with Rad23p misfolded or incompletely synthesized protein catabolic process|protein deglycosylation peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity cytosol|mitochondrion|nucleus
YGR023W YGR023W MTL1 hom Verified 0.469120482725984 0.319491759533229 no 1497 0.314658276084801 1044 NA FT CELL WALL ORG/BIOGENESIS|RESPONSE TO NUTRIENT LEVELS|RESPONSE TO OXIDATIVE STRESS PLASMA MEMBRANE Putative plasma membrane sensor, involved in cell integrity signaling and stress response during glucose starvation and oxidative stress; has structural and functional similarity to Mid2p cellular response to glucose starvation|fungal-type cell wall organization|cellular response to oxidative stress molecular_function integral to plasma membrane
YBR283C YBR283C SSH1 hom Verified 0.468510003649665 0.319709959431787 no 1498 0.287984732737682 938 NA FT PROTEIN LOCALIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Subunit of the Ssh1 translocon complex; Sec61p homolog involved in co-translational pathway of protein translocation; not essential SRP-dependent cotranslational protein targeting to membrane protein transmembrane transporter activity|signal sequence binding integral to membrane|Ssh1 translocon complex
YIR021W-A_p YIR021W-A YIR021W-A hom Uncharacterized 0.467250973038589 0.320160164275334 no 1499 0.322230428692455 1108 NA Putative protein of unknown function; identified by expression profiling and mass spectrometry biological_process molecular_function cellular_component
YOR129C YOR129C AFI1 hom Verified 0.467105107234222 0.320212340183364 no 1500 0.310307146962817 1058 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION NUCLEUS|SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Arf3p polarization-specific docking factor, required for the polarized distribution of the ADP-ribosylation factor, Arf3p; participates in polarity development and maintenance of a normal haploid budding pattern; interacts with Cnm7p asymmetric protein localization|actin cortical patch localization|cellular bud site selection molecular_function nucleus|plasma membrane|cellular bud neck|cytoplasm
YKR019C YKR019C IRS4 hom Verified 0.466962184784522 0.320263466707519 no 1501 0.417213672116035 1378 NA FF|FT LIPID METABOLISM|SIGNALING|CELL WALL ORG/BIOGENESIS|RESPONSE TO NUTRIENT LEVELS|GENE SILENCING MITOCHONDRION EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication autophagy|fungal-type cell wall organization|chromatin silencing at rDNA|inositol lipid-mediated signaling|CVT pathway|cellular response to starvation molecular_function mitochondrion|pre-autophagosomal structure
YKL194C YKL194C MST1 hom Verified 0.465716349473127 0.320709273999073 no 1502 0.348686804552344 1164 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(XXX)Q2 in vitro mitochondrial threonyl-tRNA aminoacylation threonine-tRNA ligase activity mitochondrion
YDL144C YDL144C YDL144C hom Verified 0.465427438770296 0.32081269422209 no 1503 0.320793269342031 1095 NA FT OXIDATION-REDUCTION PROCESS NUCLEUS Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDL144C is not an essential gene; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus|cytoplasm
YBR255W YBR255W MTC4 hom Verified 0.464419699478916 0.321173539490375 no 1504 0.33966005776931 1129 NA Protein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; mtc4 is synthetically sick with cdc13-1 biological_process molecular_function cytoplasm
YBR089C-A YBR089C-A NHP6B hom Verified 0.463567567663666 0.321478797583167 no 1505 0.295916298384717 1001 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME High-mobility group (HMG) protein, binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Ap; homologous to mammalian HMGB1 and HMGB2; NHP6B has a paralog, NHP6A, that arose from the whole genome duplication RNA polymerase III transcriptional preinitiation complex assembly|chromatin remodeling|transcription from RNA polymerase II promoter nucleosome binding|DNA binding, bending|sequence-specific DNA binding nucleus
YGL200C YGL200C EMP24 hom Verified 0.462670733769169 0.321800199504909 no 1506 0.331283975032943 1138 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles protein retention in ER lumen|vesicle organization|ER to Golgi vesicle-mediated transport molecular_function integral to membrane|endoplasmic reticulum|ER to Golgi transport vesicle
YGR204C-A_p YGR204C-A YGR204C-A hom Uncharacterized 0.462642933610827 0.321810164490526 no 1507 0.312003288771619 1031 NA Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YGR159C YGR159C NSR1 hom Verified 0.461704604936937 0.32214658417036 no 1508 0.328005298048928 1085 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS|MITOCHONDRION Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis ribosomal small subunit assembly|rRNA processing single-stranded DNA binding|RNA binding mitochondrion|nucleolus|nucleus
YDR154C_d YDR154C YDR154C hom Dubious 0.460360305465775 0.322628810835044 no 1509 0.293770076697192 969 NA Dubious open reading frame, null mutant exhibits synthetic phenotype with alpha-synuclein Unknown Unknown Unknown
YOR222W YOR222W ODC2 hom Verified 0.460066581780175 0.322734215061829 no 1510 0.307855022925613 1051 NA FT MITOCHONDRION Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism mitochondrial transport dicarboxylic acid transmembrane transporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YGR152C YGR152C RSR1 hom Verified 0.459664493275509 0.322878529646195 no 1511 0.319928069422786 1098 NA FT CELL CYCLE|SIGNALING|CELL DIVISION|NUCLEOTIDE METABOLISM SITE OF POLARIZED GROWTH|PLASMA MEMBRANE GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases bipolar cellular bud site selection|small GTPase mediated signal transduction|axial cellular bud site selection|cellular bud site selection GTPase activity|signal transducer activity plasma membrane|cellular bud neck
YPL105C YPL105C SYH1 hom Verified 0.459156568472561 0.32306086832882 no 1512 0.318534689943329 1096 NA FT PROTEIN LOCALIZATION MITOCHONDRION Protein of unknown function that influences nuclear pore distribution; co-purifies with ribosomes; contains a GYF domain, which bind proline-rich sequences; deletion extends chronological lifespan; SYH1 has a paralog, SMY2, that arose from the whole genome duplication nuclear pore distribution molecular_function mitochondrion|ribosome|cytoplasmic mRNA processing body|extrinsic to membrane|cytoplasm
YMR042W YMR042W ARG80 hom Verified 0.458669284457668 0.323235837198024 no 1513 0.32153310055995 1074 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Transcription factor involved in regulation of arginine-responsive genes; acts with Arg81p and Arg82p Unknown|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding nucleus
YHL014C YHL014C YLF2 hom Verified 0.458430106015683 0.323321733213813 no 1514 0.324041814321498 1130 NA FT MITOCHONDRION Protein of unknown function, has weak similarity to E. coli GTP-binding protein gtp1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process GTP binding mitochondrion
YLR133W YLR133W CKI1 hom Verified 0.458195320317575 0.323406060826887 no 1515 0.361289633110108 1225 NA FT LIPID METABOLISM Choline kinase; catalyzes the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; CKI1 has a paralog, EKI1, that arose from the whole genome duplication phosphatidylethanolamine biosynthetic process|phosphatidylcholine biosynthetic process ethanolamine kinase activity|choline kinase activity cytoplasm
YDL142C YDL142C CRD1 hom Verified 0.455754877173144 0.324283127548094 no 1516 0.321102189314163 1088 NA FT LIPID METABOLISM|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS MITOCHONDRION Cardiolipin synthase; produces cardiolipin, which is a phospholipid of the mitochondrial inner membrane that is required for normal mitochondrial membrane potential and function; also required for normal vacuolar ion homeostasis lipid biosynthetic process|cellular ion homeostasis|mitochondrial membrane organization cardiolipin synthase activity mitochondrion|integral to membrane
YHR064C YHR064C SSZ1 hom Verified 0.454648561654762 0.324681046180785 no 1517 0.280415750780587 1003 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP cytoplasmic translation|regulation of translational fidelity|rRNA processing unfolded protein binding polysome|cytoplasm
YNL291C YNL291C MID1 hom Verified 0.452093065738773 0.325600969468221 no 1518 0.307641130581225 1016 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS ENDOPLASMIC RETICULUM|PLASMA MEMBRANE N-glycosylated integral membrane protein of the ER membrane and plasma membrane, functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone; interacts with Cch1p; forms an oligomer calcium ion transport stretch-activated, cation-selective, calcium channel activity|calcium channel activity endoplasmic reticulum|plasma membrane
YPR024W YPR024W YME1 hom Verified 0.452084613481317 0.325604013865268 no 1519 0.298512249844521 1012 NA FT PROTEOLYSIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover chronological cell aging|misfolded or incompletely synthesized protein catabolic process|mitochondrion organization ATP-dependent peptidase activity mitochondrion|mitochondrial inner membrane|i-AAA complex
YBL036C YBL036C YBL036C hom Verified 0.4516589595015 0.325757344126832 no 1520 0.289512844881909 979 NA Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS biological_process pyridoxal phosphate binding cellular_component
YOR380W YOR380W RDR1 hom Verified 0.45140694121334 0.325848140752167 no 1521 0.316546634403903 1024 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Transcriptional repressor involved in the control of multidrug resistance; negatively regulates expression of the PDR5 gene; member of the Gal4p family of zinc cluster proteins response to xenobiotic stimulus sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity nucleus
YJL171C YJL171C YJL171C hom Verified 0.450152265716786 0.326300326272451 no 1522 0.291450924300052 987 NA FT MITOCHONDRION|PLASMA MEMBRANE GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress biological_process molecular_function mitochondrion|fungal-type cell wall|plasma membrane
YAL013W YAL013W DEP1 hom Verified 0.449987332759146 0.326359787182804 no 1523 0.33498062054481 1117 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Transcriptional modulator involved in regulation of structural phospholipid biosynthesis genes and metabolically unrelated genes, as well as maintenance of telomeres, mating efficiency, and sporulation positive regulation of transcription from RNA polymerase II promoter in response to heat stress|negative regulation of chromatin silencing at rDNA|regulation of transcription from RNA polymerase II promoter|histone deacetylation|negative regulation of chromatin silencing at silent mating-type cassette|negative regulation of chromatin silencing at telomere|negative regulation of transcription from RNA polymerase II promoter|regulation of DNA-dependent DNA replication initiation|Unknown molecular_function Rpd3L-Expanded complex|Rpd3L complex
YER056C YER056C FCY2 hom Verified 0.449664264216613 0.326476271231845 no 1524 0.293411795532975 973 NA FT PLASMA MEMBRANE Purine-cytosine permease; mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation; relative distribution to the vacuole increases upon DNA replication stress cytosine transport|cytidine transport|purine nucleobase transport|transmembrane transport nucleobase transmembrane transporter activity|cytidine transmembrane transporter activity integral to membrane|plasma membrane
YLR251W YLR251W SYM1 hom Verified 0.447176188666966 0.32737392616236 no 1525 0.318561789503679 1062 NA FT MITOCHONDRION Protein required for ethanol metabolism; induced by heat shock and localized to the inner mitochondrial membrane; homologous to mammalian peroxisomal membrane protein Mpv17 ethanol metabolic process molecular_function mitochondrion|integral to membrane|mitochondrial inner membrane
YOR365C_p YOR365C YOR365C hom Uncharacterized 0.446461099632884 0.327632103074912 no 1526 0.309117873167532 1027 NA Putative protein of unknown function; not an essential protein; YOR365C has a paralog, FLC2, that arose from the whole genome duplication biological_process molecular_function integral to membrane
YOR331C_d YOR331C YOR331C hom Dubious 0.446202265135308 0.327725573430283 no 1527 0.382528366882696 1247 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene VMA4/YOR332W Unknown Unknown Unknown
YFL055W YFL055W AGP3 hom Verified 0.445097723950954 0.328124566791095 no 1528 0.325572391391649 1105 NA FT PLASMA MEMBRANE Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition amino acid transport|transmembrane transport amino acid transmembrane transporter activity integral to membrane|plasma membrane
YGL194C YGL194C HOS2 hom Verified 0.444760197357511 0.328246530663808 no 1529 0.315644025535332 1075 NA FT CELL CYCLE|CHROMATIN ORGANIZATION|SIGNALING NUCLEUS|CHROMOSOME Histone deacetylase and subunit of Set3 and Rpd3L complexes; required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; co-localizes with Cmr1p in nuclear foci in response to DNA damage by MMS negative regulation of meiosis|chromatin organization|regulation of transcription, DNA-dependent|positive regulation of stress-activated MAPK cascade|histone deacetylation NAD-independent histone deacetylase activity|NAD-dependent histone deacetylase activity Rpd3L-Expanded complex|Set3 complex
YPL159C YPL159C PET20 hom Verified 0.444079516865907 0.328492547498508 no 1530 0.334630157608129 1088 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Mitochondrial protein, required for respiratory growth under some conditions and for stability of the mitochondrial genome aerobic respiration molecular_function mitochondrion
YLR247C YLR247C IRC20 hom Verified 0.442896571430359 0.328920273726385 no 1531 0.306144375284197 1041 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION Putative helicase; localizes to the mitochondrion and the nucleus; YLR247C is not an essential gene; null mutant displays increased levels of spontaneous Rad52p foci double-strand break repair via synthesis-dependent strand annealing helicase activity mitochondrion|nucleus
YGR282C YGR282C BGL2 hom Verified 0.442759102158701 0.328969994042918 no 1532 0.330966492444439 1131 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM Endo-beta-1,3-glucanase, major protein of the cell wall, involved in cell wall maintenance fungal-type cell wall organization 1,3-beta-glucanosyltransferase activity|glucan endo-1,3-beta-D-glucosidase activity fungal-type cell wall
YDR140W YDR140W MTQ2 hom Verified 0.441200905747299 0.329533778780843 no 1533 0.318324436947506 1086 NA FT TRANSLATION NUCLEUS S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC peptidyl-glutamine methylation|regulation of translation protein methyltransferase activity|S-adenosylmethionine-dependent methyltransferase activity eRF1 methyltransferase complex|nucleus|cytoplasm
YKL046C YKL046C DCW1 hom Verified 0.440979280892387 0.329613998337976 no 1534 0.293154023600843 1015 NA FT CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM PLASMA MEMBRANE Putative mannosidase, GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p fungal-type cell wall biogenesis|budding cell bud growth mannosidase activity anchored to plasma membrane
YGR003W YGR003W CUL3 hom Verified 0.440604662574103 0.329749613389752 no 1535 0.319310290048643 1046 NA FT PROTEOLYSIS NUCLEUS UBIQUITIN LIGASE COMPLEX Ubiquitin-protein ligase, forms a complex with Elc1p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; cullin family member with similarity to Cdc53p and human CUL3 protein ubiquitination involved in ubiquitin-dependent protein catabolic process|ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity nucleus|Cul3-RING ubiquitin ligase complex|cytoplasm
YJR040W YJR040W GEF1 hom Verified 0.439983920332219 0.329974376689794 no 1536 0.32982195619174 1138 NA FF|FT ION HOMEOSTASIS|ION HOMEOSTASIS ENDOPLASMIC RETICULUM|GOLGI APPARATUS|PLASMA MEMBRANE Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism cellular copper ion homeostasis|cellular iron ion homeostasis voltage-gated chloride channel activity endosome|integral to membrane|endoplasmic reticulum|Golgi apparatus|plasma membrane|fungal-type vacuole|Golgi medial cisterna
YDR359C YDR359C EAF1 hom Verified 0.438589185989203 0.330479617063969 no 1537 0.365225567890761 1182 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS HISTONE ACETYLTRANSFERASE Component of the NuA4 histone acetyltransferase complex; acts as a platform for assembly of NuA4 subunits into the native complex; required for initiation of pre-meiotic DNA replication, likely due to its requirement for expression of IME1 DNA repair|cellular protein complex assembly|chromatin modification molecular_function histone acetyltransferase complex|NuA4 histone acetyltransferase complex
YJL127C-B_p YJL127C-B YJL127C-B hom Uncharacterized 0.438466598689095 0.330524038917288 no 1538 0.316870551035989 1080 NA Putative protein of unknown function; identified based on homology to the filamentous fungus, Ashbya gossypii biological_process molecular_function cellular_component
YEL022W YEL022W GEA2 hom Verified 0.438194769622185 0.330622549896717 no 1539 0.348591114412122 1172 NA FT VESICLE-MEDIATED TRANSPORT|SIGNALING|CYTOSKELETON ORGANIZATION|RESPONSE TO NUTRIENT LEVELS GOLGI APPARATUS Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA2 has a paralog, GEA1, that arose from the whole genome duplication retrograde vesicle-mediated transport, Golgi to ER|secretory granule organization|ER to Golgi vesicle-mediated transport|macroautophagy|intra-Golgi vesicle-mediated transport|actin cytoskeleton organization ARF guanyl-nucleotide exchange factor activity integral to membrane|Golgi cis cisterna|extrinsic to membrane
YOR269W YOR269W PAC1 hom Verified 0.437737317530748 0.330788357233603 no 1540 0.303905267811091 1012 NA FT CELL CYCLE|CELL DIVISION NUCLEUS|CYTOSKELETON Involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; serves at interface between dynein's ATPase site and its microtubule binding stalk, causing individual dynein motors to remain attached to microtubules for long periods; synthetic lethal with bni1; homolog of human LIS1, mutations in which cause the severe brain disorder lissencephaly nuclear migration along microtubule microtubule plus-end binding cytoplasmic microtubule|nucleus|cytoplasm
YLR330W YLR330W CHS5 hom Verified 0.436888085693272 0.33109625643563 no 1541 0.36624100446357 1233 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM GOLGI APPARATUS|SITE OF POLARIZED GROWTH Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane ascospore wall assembly|conjugation with cellular fusion|cell wall chitin catabolic process|Golgi to plasma membrane transport|cellular bud site selection|regulation of transcription, DNA-dependent molecular_function mating projection tip|cytoplasm|exomer complex
YNL323W YNL323W LEM3 hom Verified 0.436384873700994 0.331278755909057 no 1542 0.406073891846054 1345 NA FF|FT MEMBRANE ORGANIZATION|SIGNALING ENDOPLASMIC RETICULUM|PLASMA MEMBRANE Membrane protein of the plasma membrane and ER, interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane phospholipid translocation|cell surface receptor signaling pathway phospholipid-translocating ATPase activity integral to membrane|endoplasmic reticulum|plasma membrane|cytoplasm
YGR084C YGR084C MRP13 hom Verified 0.433134715056406 0.332458452028373 no 1543 0.319065892968427 1077 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YER113C YER113C TMN3 hom Verified 0.433033294320536 0.332495291068464 no 1544 0.328901416460924 1122 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn2p; member of Transmembrane Nine family with 9 transmembrane segments; localizes to Golgi; induced by 8-methoxypsoralen plus UVA irradiation cellular copper ion homeostasis|vacuolar transport|pseudohyphal growth|invasive growth in response to glucose limitation molecular_function COPI-coated vesicle|integral to membrane|Golgi apparatus
YOR226C YOR226C ISU2 hom Verified 0.432837788584587 0.332566309155591 no 1545 0.325961356698424 1103 NA FT RNA PROCESSING|ION HOMEOSTASIS|ION HOMEOSTASIS|COFACTOR METABOLISM MITOCHONDRION Protein required for synthesis of iron-sulfur proteins; localized to the mitochondrial matrix; performs a scaffolding function in mitochondria during Fe/S cluster assembly; involved in Fe-S cluster assembly for both mitochondrial and cytosolic proteins; isu1 isu2 double mutant is inviable; protein abundance increases in response to DNA replication stress; evolutionarily conserved cellular iron ion homeostasis|iron-sulfur cluster assembly|tRNA wobble uridine modification molecular_function mitochondrial matrix
YHL029C_p YHL029C OCA5 hom Uncharacterized 0.432608417801537 0.332649636491467 no 1546 0.349004928351812 1210 NA FT SIGNALING|NUCLEOTIDE METABOLISM Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts biological_process molecular_function cytoplasm
YKR015C_p YKR015C YKR015C hom Uncharacterized 0.432450835193171 0.332706888936263 no 1547 0.315613125397098 1048 NA Putative protein of unknown function biological_process molecular_function cellular_component
YAL051W YAL051W OAF1 hom Verified 0.432118649788134 0.332827590330067 no 1548 0.326817050337004 1071 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|GENE SILENCING NUCLEUS Oleate-activated transcription factor; acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis; OAF1 has a paralog, PIP2, that arose from the whole genome duplication cellular response to oleic acid|positive regulation of fatty acid beta-oxidation|positive regulation of chromatin silencing at telomere|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YOR197W YOR197W MCA1 hom Verified 0.431402757275475 0.333087772705885 no 1549 0.321158561072515 1067 NA FT PROTEOLYSIS NUCLEUS Ca2+-dependent cysteine protease; may cleave specific substrates during the stress response; regulates apoptosis upon H2O2 treatment; required for clearance of insoluble protein aggregates during normal growth; implicated in cell cycle dynamics; undergoes autocatalytic processing; similar to mammalian metacaspases, but exists as a monomer due to an extra pair of anti-parallel beta-strands that form a continuous beta-sheet, blocking potential dimerization misfolded or incompletely synthesized protein catabolic process|apoptotic process cysteine-type peptidase activity nucleus
YBL031W YBL031W SHE1 hom Verified 0.43109146869164 0.333200931810235 no 1550 0.34138796773203 1132 NA FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION NUCLEUS|SITE OF POLARIZED GROWTH|CYTOSKELETON Mitotic spindle protein; interacts with components of the Dam1 (DASH) complex, its effector Sli15p, and microtubule-associated protein Bim1p; also localizes to nuclear microtubules and to the bud neck in a ring-shaped structure; inhibits dynein function mitotic spindle elongation molecular_function microtubule cytoskeleton|nuclear microtubule|cellular bud neck|astral microtubule|spindle
YDR175C YDR175C RSM24 hom Verified 0.43081920784217 0.333299916067963 no 1551 0.338546664728629 1140 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YBR246W YBR246W RRT2 hom Verified 0.430078444825463 0.333569289626783 no 1552 0.348276728010195 1163 NA FT VESICLE-MEDIATED TRANSPORT Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription peptidyl-diphthamide biosynthetic process from peptidyl-histidine|endocytic recycling molecular_function endosome|cytoplasm
YML080W YML080W DUS1 hom Verified 0.429908273378201 0.333631183473228 no 1553 0.28776122937419 956 NA FT RNA PROCESSING|OXIDATION-REDUCTION PROCESS NUCLEUS Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNA(Phe) at U17 tRNA modification tRNA dihydrouridine synthase activity nucleus
YBL005W YBL005W PDR3 hom Verified 0.428379000353357 0.334187605479853 no 1554 0.325734494550823 1117 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Transcriptional activator of the pleiotropic drug resistance network; regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements); post-translationally up-regulated in cells lacking a functional mitochondrial genome; PDR3 has a paralog, PDR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress Unknown|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus|cytoplasm
YBR224W_d YBR224W YBR224W hom Dubious 0.428164064865023 0.334265838447607 no 1555 0.324432541100359 1071 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TDP1 Unknown Unknown Unknown
YPL031C YPL031C PHO85 hom Verified 0.427343047933204 0.334564741303521 no 1556 0.3739411509701 1228 NA FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE|CELL WALL ORG/BIOGENESIS|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS|GEN. OF PRECURSOR METABOLITES A NUCLEUS Cyclin-dependent kinase, with ten cyclin partners; involved in regulating the cellular response to nutrient levels and environmental conditions and progression through the cell cycle regulation of transcription involved in G1/S phase of mitotic cell cycle|negative regulation of calcium-mediated signaling|regulation of protein stability|regulation of protein localization|protein phosphorylation|response to DNA damage stimulus|negative regulation of phosphate metabolic process|fungal-type cell wall organization|regulation of establishment or maintenance of cell polarity|negative regulation of glycogen biosynthetic process|negative regulation of transcription from RNA polymerase II promoter|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of macroautophagy|negative regulation of macroautophagy protein kinase activity|cyclin-dependent protein kinase activity cyclin-dependent protein kinase holoenzyme complex|nucleus
YNR015W YNR015W SMM1 hom Verified 0.427104707187696 0.334651532283385 no 1557 0.310030554591059 1038 NA FT RNA PROCESSING|OXIDATION-REDUCTION PROCESS NUCLEUS Dihydrouridine synthase, member of a family of dihydrouridine synthases including Dus1p, Smm1p, Dus3p, and Dus4p; modifies uridine residues at position 20 of cytoplasmic tRNAs tRNA processing|tRNA modification tRNA dihydrouridine synthase activity nucleus|cytoplasm
YOR133W YOR133W EFT1 hom Verified 0.426820607037036 0.33475499793901 no 1558 0.341254336134692 1142 NA FT TRANSLATION|NUCLEOTIDE METABOLISM RIBOSOME Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication translational elongation translation elongation factor activity ribosome
YDR150W YDR150W NUM1 hom Verified 0.426774746304462 0.334771701009927 no 1559 0.363269647649572 1218 NA FT PROTEIN LOCALIZATION|MITOCHONDRION ORGANIZATION|CYTOSKELETON ORGANIZATION MITOCHONDRION|SITE OF POLARIZED GROWTH Protein required for nuclear migration, localizes to the mother cell cortex and the bud tip; may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex mitochondrion inheritance|nuclear migration along microtubule|mitochondrial fission|microtubule cytoskeleton organization tubulin binding cell cortex|mitochondrion|cellular bud tip
YMR252C_p YMR252C YMR252C hom Uncharacterized 0.426773003803999 0.33477233565754 no 1560 0.325818709102439 1105 NA FT MITOCHONDRION Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YMR252C is not an essential gene biological_process molecular_function mitochondrion
YNR069C YNR069C BSC5 hom Verified 0.426378661514459 0.334915973805883 no 1561 0.339159231669029 1156 NA Protein of unknown function; shows homology with N-terminal end of Bul1p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough expression includes YNR068C and the locus for this readthrough is termed BUL3; Bul3p is involved in ubiquitin-mediated sorting of plasma membrane proteins; readthrough and shortened forms of Bul3p interact with Rsp5p differently in vitro biological_process molecular_function cellular_component
YHR129C YHR129C ARP1 hom Verified 0.424497030014869 0.335601685428458 no 1562 0.333704591610088 1125 NA FT CELL CYCLE|CYTOSKELETON ORGANIZATION CYTOSKELETON Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; putative ortholog of mammalian centractin nuclear migration|establishment of mitotic spindle orientation structural constituent of cytoskeleton cell cortex|dynactin complex|spindle pole body|astral microtubule
YLR271W_p YLR271W YLR271W hom Uncharacterized 0.421507215547432 0.33669237169177 no 1563 0.317002250468042 1051 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS biological_process molecular_function nucleus|cytoplasm
YMR178W YMR178W YMR178W hom Verified 0.421371173841685 0.336742032570129 no 1564 0.318749223646849 1064 NA FT COFACTOR METABOLISM NUCLEUS Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; YMR178W is not an essential gene; protein abundance increases in response to DNA replication stress biological_process molecular_function nucleus|cytoplasm
YGR271W YGR271W SLH1 hom Verified 0.420809402312538 0.336947132674938 no 1565 0.326715120399723 1121 NA FT TRANSLATION RIBOSOME Putative RNA helicase related to Ski2p, involved in translation inhibition of non-poly(A) mRNAs; required for repressing propagation of dsRNA viruses cytoplasmic translation|regulation of translation RNA helicase activity polysomal ribosome|cytoplasm
YML032C YML032C RAD52 hom Verified 0.420487475610501 0.337064688437364 no 1566 0.340619613602316 1103 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis postreplication repair|telomere maintenance via recombination|meiotic joint molecule formation|meiotic DNA recombinase assembly|DNA recombinase assembly|DNA strand renaturation|double-strand break repair via synthesis-dependent strand annealing|double-strand break repair via single-strand annealing|double-strand break repair via break-induced replication recombinase activity nuclear chromosome|nucleus
YJL088W YJL088W ARG3 hom Verified 0.419257369454281 0.337514024348516 no 1567 0.34956939971234 1165 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Ornithine carbamoyltransferase (carbamoylphosphate:L-ornithine carbamoyltransferase), catalyzes the sixth step in the biosynthesis of the arginine precursor ornithine arginine biosynthetic process|ornithine metabolic process ornithine carbamoyltransferase activity cytosol
YGR121C YGR121C MEP1 hom Verified 0.41922143121124 0.337527155437501 no 1568 0.320823743504846 1085 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation nitrogen utilization|ammonium transport ammonium transmembrane transporter activity integral to membrane|plasma membrane
YJR010W YJR010W MET3 hom Verified 0.419032490739454 0.337596193622839 no 1569 0.346329604317906 1178 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)|sulfur amino acid metabolic process sulfate adenylyltransferase (ATP) activity mitochondrion|cytoplasm
YHR017W YHR017W YSC83 hom Verified 0.418446459364099 0.337810362191875 no 1570 0.35636817472646 1197 NA FT MITOCHONDRION Non-essential mitochondrial protein of unknown function; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83 biological_process molecular_function mitochondrial outer membrane|mitochondrion
YJL216C YJL216C IMA5 hom Verified 0.418290333341782 0.337867428216538 no 1571 0.349910089986941 1173 NA FT CARBOHYDRATE METABOLISM Alpha-glucosidase; specificity for isomaltose, maltose, and palatinose, but not alpha-methylglucoside; member of the IMA isomaltase family; not required for isomaltose utilization, but Ima5p overexpression allows the ima1 null mutant to grow on isomaltose disaccharide catabolic process oligo-1,6-glucosidase activity cellular_component
YEL027W YEL027W VMA3 hom Verified 0.417832349474817 0.338034848576539 no 1572 0.351750199405905 1163 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis cellular copper ion homeostasis|cellular iron ion homeostasis|endocytosis|vacuole organization|proton transport|vacuolar acidification|protein targeting to vacuole hydrogen ion transmembrane transporter activity vacuolar proton-transporting V-type ATPase, V0 domain|integral to membrane
YKL002W YKL002W DID4 hom Verified 0.41691287903766 0.338371066449303 no 1573 0.341259996311004 1174 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT Class E Vps protein of the ESCRT-III complex, required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis protein retention in Golgi apparatus|intralumenal vesicle formation|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|late endosome to vacuole transport molecular_function ESCRT III complex|cytoplasm
YKL047W_p YKL047W ANR2 hom Uncharacterized 0.416826266725785 0.338402744160637 no 1574 0.337526493937445 1133 NA Putative protein of unknown function, predicted to be palmitoylated; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm biological_process molecular_function cytoplasm
YLL027W YLL027W ISA1 hom Verified 0.416093994049298 0.338670612310596 no 1575 0.354383657314216 1209 NA FT KETONE METABOLISM|COFACTOR METABOLISM MITOCHONDRION Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa2p and possibly Iba57p; isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources; functional ortholog of bacterial A-type ISC proteins biotin biosynthetic process|iron-sulfur cluster assembly iron-sulfur cluster binding|iron ion binding mitochondrial matrix
YDL170W YDL170W UGA3 hom Verified 0.415574067209806 0.338860853102455 no 1576 0.334569811440754 1117 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM|RESPONSE TO NUTRIENT LEVELS NUCLEUS Transcriptional activator necessary for gamma-aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1, UGA2, UGA4); zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus nitrogen utilization|nitrogen catabolite activation of transcription from RNA polymerase II promoter|gamma-aminobutyric acid catabolic process sequence-specific DNA binding transcription factor recruiting transcription factor activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YOR219C YOR219C STE13 hom Verified 0.414152556672532 0.33938119232875 no 1577 0.351470558893545 1184 NA FT PROTEOLYSIS GOLGI APPARATUS Dipeptidyl aminopeptidase, Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences, required for maturation of alpha factor, transcription is induced by a-factor peptide pheromone maturation aminopeptidase activity trans-Golgi network
YGR104C YGR104C SRB5 hom Verified 0.412859828981072 0.339854657085167 no 1578 0.355353471138387 1164 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; required for proper termination of transcription for some genes; involved in telomere maintenance transcriptional open complex formation at RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter core RNA polymerase II binding transcription factor activity|RNA polymerase II transcription factor recruiting transcription factor activity|TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly core mediator complex
YDR094W_d YDR094W YDR094W hom Dubious 0.412505592379423 0.339984441277068 no 1579 0.318074837489686 1067 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2 Unknown Unknown Unknown
YKL222C YKL222C YKL222C hom Verified 0.410989011383295 0.340540296129014 no 1580 0.339842894617142 1108 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS|CYTOSKELETON Protein of unknown function that may interact with ribosomes, based on co-purification experiments; similar to transcriptional regulators from the zinc cluster (binuclear cluster) family; null mutant is sensitive to caffeine biological_process sequence-specific DNA binding ribosome|nucleus|mitotic spindle
YLR261C_d YLR261C VPS63 hom Dubious 0.410755598055805 0.340625877211458 no 1581 0.410963283324342 1354 NA FF Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect Unknown Unknown Unknown
YMR170C YMR170C ALD2 hom Verified 0.410692297550614 0.340649087779547 no 1582 0.332853591105294 1108 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p cellular aldehyde metabolic process|beta-alanine biosynthetic process|polyamine catabolic process aldehyde dehydrogenase (NAD) activity cytoplasm
YJL047C-A_p YJL047C-A YJL047C-A hom Uncharacterized 0.410542212150459 0.340704122411969 no 1583 0.336848132563363 1108 NA Putative protein of unknown function biological_process molecular_function cellular_component
YJL147C_p YJL147C YJL147C hom Uncharacterized 0.410462777614496 0.340733251537555 no 1584 0.330016255518622 1133 NA FT MITOCHONDRION Mitochondrial protein of unknown function; homozygous diploid deletion strain has a sporulation defect characterized by elevated dityrosine in the soluble fraction; expression induced by calcium shortage; YJL147W is a non-essential gene biological_process molecular_function mitochondrion
YLR365W_d YLR365W YLR365W hom Dubious 0.410292743237033 0.340795607366151 no 1585 0.314614314137975 1057 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious gene YLR364C-A; YLR365W is not an essential gene Unknown Unknown Unknown
YGR019W YGR019W UGA1 hom Verified 0.409913730160971 0.34093461652687 no 1586 0.332666400093027 1116 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Gamma-aminobutyrate (GABA) transaminase; also known as 4-aminobutyrate aminotransferase; involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization; protein abundance increases in response to DNA replication stress nitrogen utilization|gamma-aminobutyric acid catabolic process 4-aminobutyrate transaminase activity intracellular
YML013W YML013W UBX2 hom Verified 0.409738636355652 0.340998842299707 no 1587 0.399969686912426 1344 NA FF|FT PROTEOLYSIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION UBIQUITIN LIGASE COMPLEX Bridging factor involved in ER-associated protein degradation (ERAD); bridges the cytosolic Cdc48p-Npl1p-Ufd1p ATPase complex and the membrane associated Ssm4p and Hrd1p ubiquitin ligase complexes; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain; redistributes from the ER to lipid droplets during the diauxic shift and stationary phase; required for the maintenance of lipid homeostasis proteasomal ubiquitin-dependent protein catabolic process|ER-associated protein catabolic process|lipid particle organization protein binding, bridging mitochondrial outer membrane|Doa10p ubiquitin ligase complex|integral to endoplasmic reticulum membrane|lipid particle|endoplasmic reticulum
YCR011C YCR011C ADP1 hom Verified 0.409066397637706 0.341245467494244 no 1588 0.323680372893579 1117 NA FT NUCLEOTIDE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Putative ATP-dependent permease of the ABC transporter family of proteins transport|transmembrane transport ATPase activity, coupled to transmembrane movement of substances integral to membrane|endoplasmic reticulum|cytoplasm
YOL151W YOL151W GRE2 hom Verified 0.408149580908392 0.341581930695737 no 1589 0.314689381702313 1066 NA FT LIPID METABOLISM|OXIDATION-REDUCTION PROCESS NUCLEUS 3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase (D-lactaldehyde dehydrogenase); stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress ergosterol metabolic process|filamentous growth methylglyoxal reductase (NADPH-dependent) activity|3-methylbutanol:NAD(P) oxidoreductase activity nucleus|cytoplasm
YJL124C YJL124C LSM1 hom Verified 0.408141508714477 0.341584893675325 no 1590 0.358638976985304 1200 NA FF|FT RNA PROCESSING NUCLEUS Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; forms cytoplasmic foci upon DNA replication stress deadenylation-dependent decapping of nuclear-transcribed mRNA|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay RNA binding|RNA cap binding mRNA cap binding complex|cytoplasmic mRNA processing body|cytoplasm
YNL130C-A_p YNL130C-A DGR1 hom Uncharacterized 0.407953487358791 0.341653911557688 no 1591 0.329337823397616 1107 NA FT MITOCHONDRION Protein of unknown function; dgr1 null mutant is resistant to 2-deoxy-D-glucose biological_process molecular_function cellular_component
YNL014W YNL014W HEF3 hom Verified 0.407056842744639 0.341983119896439 no 1592 0.351263353851623 1193 NA FT TRANSLATION|NUCLEOTIDE METABOLISM RIBOSOME Translational elongation factor EF-3; member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells; HEF3 has a paralog, YEF3, that arose from the whole genome duplication translational elongation ATPase activity|translation elongation factor activity cytosolic ribosome
YDR158W YDR158W HOM2 hom Verified 0.405149641981725 0.342683759260494 no 1593 0.371826193189709 1262 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS NUCLEUS Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis methionine biosynthetic process|threonine biosynthetic process|homoserine biosynthetic process aspartate-semialdehyde dehydrogenase activity nucleus|plasma membrane|cytoplasm
YLR443W YLR443W ECM7 hom Verified 0.404501328098621 0.342922050729021 no 1594 0.342953521581226 1204 NA FT ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency fungal-type cell wall organization|calcium ion transport molecular_function integral to membrane
YDR475C YDR475C JIP4 hom Verified 0.404059370992697 0.343084530416109 no 1595 0.336115539332743 1124 NA Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence biological_process molecular_function cellular_component
YIL163C_p YIL163C YIL163C hom Uncharacterized 0.403331999484901 0.343352002100252 no 1596 0.336564509197303 1119 NA Protein of unknown function; mRNA identified as translated by ribosome profiling data biological_process molecular_function cellular_component
YNR041C YNR041C COQ2 hom Verified 0.403033195215984 0.343461902236407 no 1597 0.343605304112643 1155 NA FT KETONE METABOLISM|LIPID METABOLISM|COFACTOR METABOLISM MITOCHONDRION Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis ubiquinone biosynthetic process 4-hydroxybenzoate octaprenyltransferase activity mitochondrion|integral to mitochondrial membrane|integral to membrane
YGL176C_p YGL176C YGL176C hom Uncharacterized 0.40196515801214 0.343854834204361 no 1598 0.353606204695874 1147 NA Putative protein of unknown function; deletion mutant is viable and has no detectable phenotype biological_process molecular_function cellular_component
YLR262C YLR262C YPT6 hom Verified 0.401008740793845 0.344206844276145 no 1599 0.407844106039368 1330 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING GOLGI APPARATUS|PLASMA MEMBRANE Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6 intracellular protein transport|retrograde transport, endosome to Golgi GTPase activity Golgi apparatus
YJR082C YJR082C EAF6 hom Verified 0.400911264626891 0.344242728039222 no 1600 0.33256810234195 1112 NA FT CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS HISTONE ACETYLTRANSFERASE Subunit of the NuA4 acetyltransferase complex that acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3 DNA repair|histone acetylation histone acetyltransferase activity nucleus|NuA4 histone acetyltransferase complex|NuA3 histone acetyltransferase complex
YDR191W YDR191W HST4 hom Verified 0.40071046039564 0.344316654235742 no 1601 0.345008094289295 1169 NA FT KETONE METABOLISM|LIPID METABOLISM|CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism short-chain fatty acid metabolic process|chromatin silencing at telomere|histone deacetylation histone deacetylase activity|DNA binding nucleus|cytoplasm
YLR408C_p YLR408C BLS1 hom Uncharacterized 0.400668647951467 0.344332048260171 no 1602 0.325664995947705 1079 NA Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene biological_process molecular_function endosome|BLOC-1 complex
YPR005C YPR005C HAL1 hom Verified 0.398973692884291 0.34495629417967 no 1603 0.334534642049734 1116 NA FT TRANSCRIPTION FROM RNA POL II Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p response to salt stress|positive regulation of transcription from RNA polymerase II promoter molecular_function cytoplasm
YIL110W YIL110W HPM1 hom Verified 0.398813327019066 0.345015378247737 no 1604 0.336110926009521 1113 NA FT NUCLEUS AdoMet-dependent methyltransferase involved in a novel 3-methylhistidine modification of ribosomal protein Rpl3p; seven beta-strand MTase family member; null mutant exhibits a weak vacuolar protein sorting defect and caspofungin resistance peptidyl-histidine methylation, to form tele-methylhistidine S-adenosylmethionine-dependent methyltransferase activity|protein-histidine N-methyltransferase activity nucleus|cytoplasm
YHL016C YHL016C DUR3 hom Verified 0.398167546860401 0.345253343168775 no 1605 0.325710575464375 1089 NA FT PLASMA MEMBRANE Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway urea transport|spermidine transport|putrescine transport|urea catabolic process urea transmembrane transporter activity|spermidine transmembrane transporter activity|putrescine transmembrane transporter activity integral to membrane|plasma membrane
YPL184C YPL184C MRN1 hom Verified 0.398042240563881 0.345299524647543 no 1606 0.346420602209643 1191 NA FT TRANSLATION RNA-binding protein that may be involved in translational regulation; binds specific categories of mRNAs, including those that contain upstream open reading frames (uORFs) and internal ribosome entry sites (IRES); interacts genetically with chromatin remodelers and splicing factors, linking chromatin state, splicing and as a result mRNA maturation biological_process molecular_function cytoplasm
YGL190C YGL190C CDC55 hom Verified 0.39792659020389 0.345342149487048 no 1607 0.45389908140865 1499 NA FT CELL CYCLE|SIGNALING NUCLEUS|SITE OF POLARIZED GROWTH Non-essential regulatory subunit B of protein phosphatase 2A (PP2A); localization to the cytoplasm requires Zds1p and Zds2p and promotes mitotic entry; localization to the nucleus prevents mitotic exit; required for correct nuclear division and chromosome segregation in meiosis; maintains nucleolar sequestration of Cdc14p during early meiosis; limits formation of PP2A-Rts1p holocomplexes to ensure timely dissolution of sister chromosome cohesion negative regulation of exit from mitosis|positive regulation of G2/M transition of mitotic cell cycle|cell shape checkpoint|protein dephosphorylation protein phosphatase type 2A regulator activity nucleus|cellular bud neck|cytoplasm|cellular bud tip
YDR102C_d YDR102C YDR102C hom Dubious 0.397698557949874 0.345426200265943 no 1608 0.334518408588915 1112 NA Dubious open reading frame; homozygous diploid deletion strain exhibits high budding index Unknown Unknown Unknown
YGR018C_p YGR018C YGR018C hom Uncharacterized 0.397633806015077 0.345450068676524 no 1609 0.329276574288505 1086 NA Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the uncharacterized ORF YGR017W biological_process molecular_function cellular_component
YLR221C YLR221C RSA3 hom Verified 0.397621422019927 0.345454633649217 no 1610 0.331962665872907 1088 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS NUCLEUS Protein with a likely role in ribosomal maturation, required for accumulation of wild-type levels of large (60S) ribosomal subunits; binds to the helicase Dbp6p in pre-60S ribosomal particles in the nucleolus ribosomal large subunit assembly molecular_function nucleolus|preribosome, large subunit precursor
YHL032C YHL032C GUT1 hom Verified 0.397228794820802 0.345599375043428 no 1611 0.327692036795733 1133 NA FT CARBOHYDRATE METABOLISM MITOCHONDRION Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p glycerol metabolic process glycerol kinase activity mitochondrion|cytoplasm
YDR272W YDR272W GLO2 hom Verified 0.396475364120779 0.345877189287467 no 1612 0.358257756909691 1217 NA FT KETONE METABOLISM|CARBOHYDRATE METABOLISM Cytoplasmic glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate cellular carbohydrate metabolic process|methylglyoxal catabolic process to D-lactate hydroxyacylglutathione hydrolase activity cytoplasm
YGR025W_d YGR025W YGR025W hom Dubious 0.39583035614618 0.346115090517654 no 1613 0.324884559919672 1092 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YKR084C YKR084C HBS1 hom Verified 0.39384365047713 0.346848237572033 no 1614 0.354208743184883 1181 NA FT TRANSLATION|NUCLEOTIDE METABOLISM GTPase with similarity to translation release factors; together with binding partner Dom34p, facilitates ribosomal subunit dissociation and peptidyl-tRNA release when translation is stalled; genetically implicated in mRNA no-go decay nuclear-transcribed mRNA catabolic process, no-go decay|ribosome disassembly|nonfunctional rRNA decay ribosome binding|GTPase activity cytoplasm
YML028W YML028W TSA1 hom Verified 0.393824133002549 0.3468554428881 no 1615 0.342656530097067 1105 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|TRANSLATION|OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS Thioredoxin peroxidase; acts as both a ribosome-associated and free cytoplasmic antioxidant; self-associates to form a high-molecular weight chaperone complex under oxidative stress; deletion results in mutator phenotype; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress protein folding|cellular response to oxidative stress|replicative cell aging|DNA protection|DNA damage checkpoint|cell redox homeostasis|response to hydroperoxide unfolded protein binding|ribosome binding|peroxiredoxin activity|thioredoxin peroxidase activity cytosol|polysome|cytoplasm
YFR012W-A_p YFR012W-A YFR012W-A hom Uncharacterized 0.393430129858646 0.347000909878497 no 1616 0.322433772533999 1112 NA Putative protein of unknown function; identified by homology biological_process molecular_function cellular_component
YHL020C YHL020C OPI1 hom Verified 0.391874454611339 0.347575489363723 no 1617 0.360793899990815 1231 NA FT TRANSCRIPTION FROM RNA POL II|LIPID METABOLISM|SIGNALING ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Transcriptional regulator of a variety of genes; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; involved in telomere maintenance endoplasmic reticulum unfolded protein response|negative regulation of transcription from RNA polymerase II promoter|phospholipid biosynthetic process|positive regulation of transcription from RNA polymerase II promoter transcription corepressor activity nuclear membrane|nucleoplasm|nuclear envelope|endoplasmic reticulum|nucleus
YDR517W YDR517W GRH1 hom Verified 0.391477676395777 0.347722093186405 no 1618 0.333110558967638 1156 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Acetylated cis-Golgi protein, involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes; protein abundance increases in response to DNA replication stress protein secretion|ER to Golgi vesicle-mediated transport|Golgi organization molecular_function COPII vesicle coat|cis-Golgi network|cytoplasm
YGR209C YGR209C TRX2 hom Verified 0.389624525763025 0.348407106845617 no 1619 0.330048589755508 1126 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|RESPONSE TO OXIDATIVE STRESS ENDOMEMBRANE SYSTEM|NUCLEUS|GOLGI APPARATUS Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p; required for ER-Golgi transport and vacuole inheritance; protein abundance increases in response to DNA replication stress vacuole inheritance|regulation of DNA replication|cell redox homeostasis|protein deglutathionylation|sulfate assimilation|retrograde vesicle-mediated transport, Golgi to ER|cellular response to oxidative stress|ER to Golgi vesicle-mediated transport|vacuole fusion, non-autophagic disulfide oxidoreductase activity cytosol|fungal-type vacuole
YJL049W_p YJL049W YJL049W hom Uncharacterized 0.389342010899827 0.348511581449635 no 1620 0.304019491959127 1012 NA FT PROTEIN LOCALIZATION Putative protein of unknown function; YJL049W is a non-essential gene biological_process molecular_function cellular_component
YOR086C YOR086C TCB1 hom Verified 0.387418489787043 0.349223208824724 no 1621 0.323932883202284 1080 NA FT ENDOPLASMIC RETICULUM|MITOCHONDRION|PLASMA MEMBRANE Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains three calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact biological_process lipid binding mitochondrion|plasma membrane|cortical endoplasmic reticulum
YGL032C YGL032C AGA2 hom Verified 0.387287458511043 0.349271704583475 no 1622 0.346976321766609 1168 NA Adhesion subunit of a-agglutinin of a-cells, C-terminal sequence acts as a ligand for alpha-agglutinin (Sag1p) during agglutination, modified with O-linked oligomannosyl chains, linked to anchorage subunit Aga1p via two disulfide bonds agglutination involved in conjugation with cellular fusion cell adhesion molecule binding fungal-type cell wall
YPL084W YPL084W BRO1 hom Verified 0.386565936053853 0.349538790079571 no 1623 0.356839145503033 1190 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes protein deubiquitination|vacuolar transport|protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|response to nutrient|ubiquitin-dependent protein catabolic process ubiquitin-specific protease activity endosome|cytoplasm
YDL024C YDL024C DIA3 hom Verified 0.385518755842546 0.349926556596939 no 1624 0.369159374248304 1239 NA Protein of unknown function, involved in invasive and pseudohyphal growth pseudohyphal growth|invasive growth in response to glucose limitation acid phosphatase activity fungal-type cell wall
YDR465C YDR465C RMT2 hom Verified 0.383390555911294 0.350715102336832 no 1625 0.373290051575676 1235 NA FT NUCLEUS Arginine N5 methyltransferase; methylates ribosomal protein Rpl12 (L12) on Arg67; relative distribution to the nucleus increases upon DNA replication stress peptidyl-arginine methylation protein-arginine N5-methyltransferase activity nucleus|cytoplasm
YHL030W YHL030W ECM29 hom Verified 0.383237088114571 0.350771990510453 no 1626 0.34297652824461 1154 NA FT PROTEIN COMPLEX ORG/BIOGENESIS NUCLEUS Scaffold protein; assists in association of the proteasome core particle with the regulatory particle; degraded by the mature proteasome after assembly; contains HEAT-like repeats; protein increases in abundance and relocalizes from nucleus to cytoplasm upon DNA replication stress proteasome assembly protein complex scaffold proteasome complex|nucleus|cytoplasm
YKR018C YKR018C YKR018C hom Verified 0.382294171474591 0.351121588730189 no 1627 0.350193100636993 1167 NA FT NUCLEUS|MITOCHONDRION Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress; YKR018C has a paralog, IML2, that arose from the whole genome duplication biological_process molecular_function nucleus|cytoplasm
YKL212W YKL212W SAC1 hom Verified 0.382191583354888 0.351159632175009 no 1628 0.421467810363621 1388 NA FF|FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS Phosphatidylinositol phosphate (PtdInsP) phosphatase; involved in hydrolysis of PtdIns[4]P in the early and medial Golgi; regulated by interaction with Vps74p; ER localized transmembrane protein which cycles through the Golgi; involved in protein trafficking and processing, secretion, and cell wall maintenance; regulates sphingolipid biosynthesis through the modulation of PtdIns(4)P metabolism phosphatidylinositol dephosphorylation phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity|phosphatidylinositol-3-phosphatase activity|phosphatidylinositol-4-phosphate phosphatase activity mitochondrial outer membrane|integral to endoplasmic reticulum membrane|mitochondrion|SPOTS complex|integral to Golgi membrane
YMR163C YMR163C INP2 hom Verified 0.381870642641465 0.351278658417052 no 1629 0.33997324330485 1123 NA FT PEROXISOME ORGANIZATION Peroxisome-specific receptor important for peroxisome inheritance; co-fractionates with peroxisome membranes and co-localizes with peroxisomes in vivo; physically interacts with the myosin V motor Myo2p; INP2 is not an essential gene peroxisome inheritance protein anchor peroxisome|integral to peroxisomal membrane|cytoplasm
YLR335W YLR335W NUP2 hom Verified 0.381510561521423 0.35141221790001 no 1630 0.366923609914889 1238 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|RNA LOCALIZATION|GENE SILENCING ENDOMEMBRANE SYSTEM|NUCLEUS|MITOCHONDRION|CHROMOSOME NUCLEAR PORE Nucleoporin involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization rRNA export from nucleus|snRNA export from nucleus|nuclear pore organization|tRNA export from nucleus|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|mRNA-binding (hnRNP) protein import into nucleus|ribosomal protein import into nucleus|snRNP protein import into nucleus|chromatin silencing at telomere|chromatin silencing at silent mating-type cassette|protein targeting to membrane|poly(A)+ mRNA export from nucleus|protein export from nucleus|mRNA export from nucleus in response to heat stress|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery|NLS-bearing substrate import into nucleus|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, non-stop decay nucleocytoplasmic transporter activity nuclear chromatin|mitochondrion|integral to membrane|nuclear pore
YMR186W YMR186W HSC82 hom Verified 0.379724459973894 0.352074980678321 no 1631 0.355109952513007 1195 NA FT PROTEIN COMPLEX ORG/BIOGENESIS MITOCHONDRION Cytoplasmic chaperone of the Hsp90 family; redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock; contains two acid-rich unstructured regions that promote the solubility of chaperone-substrate complexes; HSC82 has a paralog, HSP82, that arose from the whole genome duplication protein folding|proteasome assembly|protein refolding|telomere maintenance|'de novo' protein folding|box C/D snoRNP assembly|response to stress unfolded protein binding|ATPase activity, coupled|ATPase activity mitochondrion|plasma membrane|cytoplasm
YDR415C_p YDR415C YDR415C hom Uncharacterized 0.378954967959924 0.352360652224635 no 1632 0.330437842446371 1117 NA FT PROTEOLYSIS Putative aminopeptidase biological_process molecular_function cellular_component
YPL071C_p YPL071C YPL071C hom Uncharacterized 0.378711677378449 0.352450990447551 no 1633 0.335094284966535 1127 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus biological_process molecular_function nucleus|cytoplasm
YMR224C YMR224C MRE11 hom Verified 0.378376695239029 0.352575389035275 no 1634 0.361777490293355 1202 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION Subunit of the MRX complex with Rad50p and Xrs2p; complex functions in repair of DNA double-strand breaks and in telomere stability; exhibits nuclease activity that appears to be required for MRX function; widely conserved; forms nuclear foci upon DNA replication stress DNA repair|meiotic DNA double-strand break formation|double-strand break repair via nonhomologous end joining|base-excision repair|ascospore formation|meiotic DNA double-strand break processing|double-strand break repair via break-induced replication|regulation of transcription during meiosis 3'-5' exonuclease activity|protein complex scaffold|double-stranded telomeric DNA binding|adenylate kinase activity|telomeric DNA binding|single-stranded telomeric DNA binding|endodeoxyribonuclease activity|G-quadruplex DNA binding|endonuclease activity mitochondrion|nucleus|Mre11 complex
YOR140W YOR140W SFL1 hom Verified 0.378244797292083 0.352624374834784 no 1635 0.346212655670352 1160 NA FT TRANSCRIPTION FROM RNA POL II|GENE SILENCING NUCLEUS Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p gene silencing|Unknown|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II repressing transcription factor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity nucleus
YLR233C YLR233C EST1 hom Verified 0.378185481458531 0.352646405038298 no 1636 0.286084624353368 946 NA FT NUCLEUS|CHROMOSOME TLC1 RNA-associated factor involved in telomere length regulation as recruitment subunit of telomerase; has G-quadruplex promoting activity that is required for telomere elongation; possible role in activating telomere-bound Est2p-TLC1-RNA telomere maintenance via telomerase|telomere maintenance|G-quadruplex DNA formation single-stranded DNA binding|RNA binding|telomeric DNA binding nucleolus|nucleus|telomerase holoenzyme complex
YBR298C YBR298C MAL31 hom Verified 0.376407881528968 0.353306843757469 no 1637 0.363535251166793 1211 NA FT CARBOHYDRATE METABOLISM Maltose permease, high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL3 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; functional in genomic reference strain S288C alpha-glucoside transport|transmembrane transport alpha-glucoside:hydrogen symporter activity integral to membrane|membrane
YGR056W YGR056W RSC1 hom Verified 0.375380407596027 0.353688786917465 no 1638 0.401921195069904 1345 NA FF|FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS RSC COMPLEX Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook double-strand break repair|ATP-dependent chromatin remodeling|regulation of sporulation resulting in formation of a cellular spore|double-strand break repair via nonhomologous end joining|nucleosome disassembly|transcription elongation from RNA polymerase II promoter DNA-dependent ATPase activity RSC complex
YER089C YER089C PTC2 hom Verified 0.375301566006705 0.353718100813743 no 1639 0.326271351861068 1101 NA FT CELL CYCLE|SIGNALING|RESPONSE TO DNA DAMAGE|PROTEIN PHOSPHORYLATION NUCLEUS Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; inactivates the DNA damage checkpoint; PTC2 has a paralog, PTC3, that arose from the whole genome duplication endoplasmic reticulum unfolded protein response|inactivation of MAPK activity involved in osmosensory signaling pathway|regulation of cyclin-dependent protein kinase activity|protein dephosphorylation|DNA damage checkpoint protein serine/threonine phosphatase activity nucleus|cytoplasm
YDL006W YDL006W PTC1 hom Verified 0.375178940300762 0.353763695697744 no 1640 0.393866077676426 1315 NA FF|FT RNA PROCESSING|SIGNALING|MITOCHONDRION ORGANIZATION|PROTEIN PHOSPHORYLATION NUCLEUS Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p, inactivating osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing, mitochondrial inheritance, and sporulation mitochondrion inheritance|inactivation of MAPK activity involved in osmosensory signaling pathway|pheromone-dependent signal transduction involved in conjugation with cellular fusion|tRNA splicing, via endonucleolytic cleavage and ligation|protein dephosphorylation protein serine/threonine phosphatase activity nucleus|cytoplasm
YPR120C YPR120C CLB5 hom Verified 0.374599754307552 0.353979077892759 no 1641 0.369609660027559 1202 NA FT CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|PROTEIN PHOSPHORYLATION NUCLEUS B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase spindle assembly|G1/S transition of mitotic cell cycle|regulation of S phase of mitotic cell cycle|G2/M transition of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity|positive regulation of spindle pole body separation|premeiotic DNA replication|positive regulation of DNA replication cyclin-dependent protein kinase regulator activity nucleus
YLL056C_p YLL056C YLL056C hom Uncharacterized 0.37208458708879 0.354914935766482 no 1642 0.316596398837314 1052 NA Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p and genes involved in pleiotropic drug resistance (PDR); expression is induced in cells treated with the mycotoxin patulin biological_process molecular_function cellular_component
YLR192C YLR192C HCR1 hom Verified 0.371972415296181 0.354956693740278 no 1643 0.390756579343273 1279 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION Dual function protein involved in translation initiation as a substoichiometric component (eIF3j) of translation initiation factor 3 (eIF3) and required for processing of 20S pre-rRNA; binds to eIF3 subunits Rpg1p and Prt1p and 18S rRNA cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) translation initiation factor activity eukaryotic translation initiation factor 3 complex
YCR098C YCR098C GIT1 hom Verified 0.371133611214516 0.35526900889391 no 1644 0.362483570505327 1228 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS PLASMA MEMBRANE Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability transmembrane transport|glycerophosphodiester transport glycerophosphodiester transmembrane transporter activity integral to membrane|plasma membrane
YJR094W-A YJR094W-A RPL43B hom Verified 0.371075374814258 0.355290695889244 no 1645 0.337214811152139 1149 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L43B; homologous to mammalian ribosomal protein L37A, no bacterial homolog; RPL43B has a paralog, RPL43A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YBR242W_p YBR242W YBR242W hom Uncharacterized 0.370288966371453 0.355583597019761 no 1646 0.390889270212063 1292 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR242W is not an essential gene biological_process molecular_function nucleus|cytoplasm
YBR052C YBR052C RFS1 hom Verified 0.370288749869975 0.3555836776684 no 1647 0.325234372086788 1086 NA FT OXIDATION-REDUCTION PROCESS Protein of unknown function; member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; RFS1 has a paralog, PST2, that arose from the whole genome duplication biological_process molecular_function membrane raft|cytoplasm
YML116W-A_d YML116W-A YML116W-A hom Dubious 0.370285929338634 0.355584728340858 no 1648 0.327681459113477 1077 NA Putative protein of unknown function Unknown Unknown Unknown
YJL144W YJL144W YJL144W hom Verified 0.368356003538534 0.356303899355599 no 1649 0.350070989800743 1165 NA Cytoplasmic hydrophilin essential in dessication-rehydration process; expression induced by osmotic stress, starvation and during stationary phase; protein abundance increases in response to DNA replication stress cellular response to water deprivation molecular_function cytoplasm
YMR152W YMR152W YIM1 hom Verified 0.36683862128491 0.356869698654287 no 1650 0.345492435931039 1174 NA FT RESPONSE TO DNA DAMAGE|OXIDATION-REDUCTION PROCESS MITOCHONDRION Protein of unknown function; null mutant displays sensitivity to DNA damaging agents; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress response to DNA damage stimulus molecular_function mitochondrion|lipid particle|cytoplasm
YGR206W YGR206W MVB12 hom Verified 0.36595520155789 0.357199252092334 no 1651 0.34707732383502 1159 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|VACUOLAR TRANSPORT ESCRT-I subunit required to stabilize oligomers of the ESCRT-I core complex (Stp22p, Vps28p, Srn2p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; deletion mutant is sensitive to rapamycin and nystatin negative regulation of protein complex assembly|protein targeting to vacuole|endosome transport via multivesicular body sorting pathway ubiquitin binding cytosol|endosome|ESCRT I complex
YML103C YML103C NUP188 hom Verified 0.365918490766138 0.357212949099366 no 1652 0.333836237363859 1110 NA FT PROTEIN LOCALIZATION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS NUCLEAR PORE Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188 nuclear pore organization|protein import into nucleus|mRNA export from nucleus in response to heat stress structural constituent of nuclear pore integral to membrane|nuclear pore|nuclear pore inner ring
YJL132W_p YJL132W YJL132W hom Uncharacterized 0.365911005352991 0.357215741972542 no 1653 0.361021905991227 1192 NA Putative protein of unknown function; localizes to the membrane fraction; possible Zap1p-regulated target gene induced by zinc deficiency; YJL132W is a non-essential gene biological_process molecular_function membrane
YKL110C YKL110C KTI12 hom Verified 0.365714123165165 0.357289203186657 no 1654 0.374351534677615 1251 NA FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p regulation of transcription from RNA polymerase II promoter|cell growth|tRNA wobble uridine modification chromatin binding nucleus|cytoplasm
YBR115C YBR115C LYS2 hom Verified 0.363428812807709 0.358142290769447 no 1655 0.347917977105123 1144 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS Alpha aminoadipate reductase, catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p lysine biosynthetic process via aminoadipic acid L-aminoadipate-semialdehyde dehydrogenase activity cytoplasm
YDL234C YDL234C GYP7 hom Verified 0.361897363397644 0.358714365148929 no 1656 0.337293972826907 1161 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|SIGNALING|NUCLEOTIDE METABOLISM GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking regulation of vacuole fusion, non-autophagic|vesicle-mediated transport Rab GTPase activator activity cytoplasm
YCR044C YCR044C PER1 hom Verified 0.361403249491401 0.358899009593748 no 1657 0.445905687292854 1438 NA FF|FT LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein of the endoplasmic reticulum, required for GPI-phospholipase A2 activity that remodels the GPI anchor as a prerequisite for association of GPI-anchored proteins with lipid rafts; functionally complemented by human ortholog PERLD1 GPI anchor biosynthetic process|cellular manganese ion homeostasis molecular_function fungal-type vacuole membrane|integral to membrane|endoplasmic reticulum
YOL011W YOL011W PLB3 hom Verified 0.361167782993295 0.358987012205886 no 1658 0.337013445580659 1111 NA FT LIPID METABOLISM PLASMA MEMBRANE Phospholipase B (lysophospholipase) involved in phospholipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro phosphatidylinositol metabolic process|phosphatidylserine catabolic process lysophospholipase activity extracellular region|plasma membrane
YOR121C_d YOR121C YOR121C hom Dubious 0.357220239254844 0.36046346770098 no 1659 0.360110762075557 1156 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GCY1/YOR120W Unknown Unknown Unknown
YNL183C YNL183C NPR1 hom Verified 0.357120434645947 0.360500823587566 no 1660 0.339939434420222 1132 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|PROTEIN PHOSPHORYLATION GOLGI APPARATUS|PLASMA MEMBRANE Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex regulation of transmembrane transporter activity|regulation of nitrogen utilization|protein phosphorylation|negative regulation of endocytosis protein serine/threonine kinase activity Golgi apparatus|plasma membrane|cytoplasm
YPL246C YPL246C RBD2 hom Verified 0.355147610861107 0.361239505052562 no 1661 0.349368206040955 1177 NA FT PROTEOLYSIS ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p biological_process molecular_function COPI-coated vesicle|integral to membrane|Golgi apparatus
YLL015W YLL015W BPT1 hom Verified 0.354743356835728 0.361390933280339 no 1662 0.323169145311866 1072 NA FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS ABC type transmembrane transporter of MRP/CFTR family, found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p cadmium ion transport|bilirubin transport bilirubin transmembrane transporter activity|cadmium ion transmembrane transporter activity fungal-type vacuole membrane|integral to membrane
YCR060W YCR060W TAH1 hom Verified 0.354492619363837 0.361484867145149 no 1663 0.36083640221991 1177 NA FT PROTEIN COMPLEX ORG/BIOGENESIS NUCLEUS Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); contains a single TPR domain with at least two TPR motifs; R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II protein folding|box C/D snoRNP assembly chaperone binding R2TP complex|nucleus|cytoplasm
YKL218C YKL218C SRY1 hom Verified 0.35314844618464 0.36198857743576 no 1664 0.359742860479534 1201 NA FT KETONE METABOLISM|AMINO ACID METABOLISM 3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required in the presence of hydroxyaspartate; highly similar to mouse serine racemase (Srr) but has no serine racemase activity cellular modified amino acid catabolic process serine racemase activity|threo-3-hydroxyaspartate ammonia-lyase activity cellular_component
YKL139W YKL139W CTK1 hom Verified 0.352255804860614 0.362323214612509 no 1665 0.382379558743127 1227 NA FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING|RESPONSE TO DNA DAMAGE|TRANSLATION|PROTEIN PHOSPHORYLATION NUCLEUS Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I); phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity; similar to the Drosophila dCDK12 and human CDK12 and probably CDK13 mRNA 3'-end processing|phosphorylation of RNA polymerase II C-terminal domain|positive regulation of translational fidelity|positive regulation of transcription from RNA polymerase I promoter|peptidyl-serine phosphorylation|positive regulation of DNA-dependent transcription, elongation|protein phosphorylation protein kinase activity|cyclin-dependent protein kinase activity nucleoplasm|nucleolus|nucleus|polysome|carboxy-terminal domain protein kinase complex
YDR433W_d YDR433W YDR433W hom Dubious 0.351211490004221 0.36271484537253 no 1666 0.371797207674786 1263 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR324W YLR324W PEX30 hom Verified 0.350599731026826 0.362944329176605 no 1667 0.384142112349303 1297 NA FF|FT PEROXISOME ORGANIZATION Peroxisomal integral membrane protein, involved in negative regulation of peroxisome number; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p peroxisome organization molecular_function integral to membrane|peroxisome|integral to peroxisomal membrane
YPL115C YPL115C BEM3 hom Verified 0.349412479002841 0.363389833063061 no 1668 0.378609277437869 1263 NA FT SIGNALING SITE OF POLARIZED GROWTH Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly negative regulation of Rho protein signal transduction|establishment of cell polarity Rho GTPase activator activity|phosphatidylinositol-3-phosphate binding cell cortex|incipient cellular bud site|mating projection tip|cytoplasm|cellular bud tip
YLR269C_d YLR269C YLR269C hom Dubious 0.349006087514692 0.363542369706271 no 1669 0.350374754473011 1161 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YKL169C_d YKL169C YKL169C hom Dubious 0.348722455737636 0.363648842038602 no 1670 0.377339953107734 1245 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL38 Unknown Unknown Unknown
YJR043C YJR043C POL32 hom Verified 0.347799106540679 0.36399553035093 no 1671 0.378466850429211 1236 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Third subunit of DNA polymerase delta, involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; interacts with Hys2p, PCNA (Pol30p), and Pol1p RNA-dependent DNA replication|lagging strand elongation|postreplication repair|base-excision repair|DNA replication, removal of RNA primer|nucleotide-excision repair|mismatch repair|double-strand break repair via break-induced replication|leading strand elongation DNA-directed DNA polymerase activity|single-stranded DNA specific 3'-5' exodeoxyribonuclease activity delta DNA polymerase complex|nucleus
YGR285C YGR285C ZUO1 hom Verified 0.347368507414295 0.364157244742559 no 1672 0.357830692060434 1204 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION NUCLEUS|MITOCHONDRION RIBOSOME Ribosome-associated chaperone, functions in ribosome biogenesis and, in partnership with Ssz1p and SSb1/2, as a chaperone for nascent polypeptide chains; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p protein folding|ribosomal subunit export from nucleus|rRNA processing|regulation of translational fidelity unfolded protein binding mitochondrion|ribosome|nucleolus|polysome|cytoplasm
YDL177C_p YDL177C YDL177C hom Uncharacterized 0.346883102258894 0.364339570909674 no 1673 0.347590724651726 1168 NA Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene biological_process molecular_function cellular_component
YIL152W_p YIL152W YIL152W hom Uncharacterized 0.346709030257282 0.364404962700359 no 1674 0.348704796666634 1165 NA Putative protein of unknown function biological_process molecular_function cellular_component
YNL273W YNL273W TOF1 hom Verified 0.346531377115636 0.364471703849384 no 1675 0.362807030744731 1175 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Subunit of a replication-pausing checkpoint complex (Tof1p-Mrc1p-Csm3p) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase DNA repair|DNA replication checkpoint|maintenance of DNA repeat elements|replication fork arrest|replication fork protection|DNA replication|mitotic sister chromatid cohesion molecular_function nuclear chromosome|replication fork protection complex|nuclear replication fork
YIL097W YIL097W FYV10 hom Verified 0.346095272576369 0.364635558045434 no 1676 0.371296264087954 1255 NA FT KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS NUCLEUS Subunit of GID complex; involved in proteasome-dependent catabolite inactivation of gluconeogenic enzymes FBPase, PEPCK, and c-MDH; forms dimer with Rmd5p that is then recruited to GID Complex by Gid8p; contains a degenerate RING finger motif needed for GID complex ubiquitin ligase activity in vivo, as well as CTLH and CRA domains; plays role in anti-apoptosis; required for survival upon exposure to K1 killer toxin negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis ubiquitin-protein ligase activity nucleus|GID complex|cytoplasm
YEL010W_d YEL010W YEL010W hom Dubious 0.346080936768095 0.364640944748174 no 1677 0.327431196127999 1109 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPL172C YPL172C COX10 hom Verified 0.345979984561145 0.364678878457044 no 1678 0.387497791997279 1279 NA FT COFACTOR METABOLISM MITOCHONDRION Heme A:farnesyltransferase, catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; human ortholog is associated with mitochondrial disorders heme a biosynthetic process protoheme IX farnesyltransferase activity mitochondrion|integral to membrane
YMR119W YMR119W ASI1 hom Verified 0.345950422998991 0.36468998673339 no 1679 0.412746136029144 1366 NA FT PROTEOLYSIS ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM Putative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals; ASI1 has a paralog, ASI3, that arose from the whole genome duplication ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity integral to membrane|nuclear inner membrane|endoplasmic reticulum membrane
YLR361C YLR361C DCR2 hom Verified 0.345865395577849 0.364721937913996 no 1680 0.341602205103152 1166 NA FT CELL CYCLE|SIGNALING Phosphoesterase involved in downregulation of the unfolded protein response, at least in part via dephosphorylation of Ire1p; dosage-dependent positive regulator of the G1/S phase transition through control of the timing of START endoplasmic reticulum unfolded protein response|traversing start control point of mitotic cell cycle|protein dephosphorylation hydrolase activity, acting on ester bonds|phosphoprotein phosphatase activity|phosphoric ester hydrolase activity cellular_component
YBR084W YBR084W MIS1 hom Verified 0.345558545406412 0.36483725235511 no 1681 0.350547572859095 1163 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM MITOCHONDRION Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase nucleobase-containing compound metabolic process|folic acid biosynthetic process formate-tetrahydrofolate ligase activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|methenyltetrahydrofolate cyclohydrolase activity mitochondrion
YMR110C YMR110C HFD1 hom Verified 0.345181303798361 0.364979036688126 no 1682 0.353463286423572 1159 NA FT OXIDATION-REDUCTION PROCESS MITOCHONDRION Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder cellular aldehyde metabolic process 3-chloroallyl aldehyde dehydrogenase activity mitochondrial outer membrane|endosome|mitochondrion|lipid particle|integral to mitochondrial outer membrane
YOR079C YOR079C ATX2 hom Verified 0.344243420141328 0.365331615450464 no 1683 0.342239292030273 1159 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Golgi membrane protein involved in manganese homeostasis; overproduction suppresses the sod1 (copper, zinc superoxide dismutase) null mutation cellular manganese ion homeostasis manganese ion transmembrane transporter activity integral to membrane|Golgi membrane
YCL014W YCL014W BUD3 hom Verified 0.343616270153956 0.365567443588126 no 1684 0.365965115060127 1236 NA FT CELL CYCLE|SIGNALING|CELL DIVISION SITE OF POLARIZED GROWTH|CYTOSKELETON Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding cellular bud site selection|axial cellular bud site selection|cytokinesis molecular_function cellular bud neck contractile ring|cellular bud neck
YLL058W_p YLL058W YLL058W hom Uncharacterized 0.34275154571487 0.365892690535094 no 1685 0.360687118964558 1217 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Putative protein of unknown function with similarity to Str2p, which is a cystathionine gamma-synthase important in sulfur metabolism; YLL058W is not an essential gene sulfur compound metabolic process cystathionine gamma-synthase activity cellular_component
YDR485C YDR485C VPS72 hom Verified 0.342669426704522 0.365923582798231 no 1686 0.40542238281876 1343 NA FF|FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting chromatin remodeling|histone exchange histone binding Swr1 complex|nucleus|cytoplasm
YMR193C-A_d YMR193C-A YMR193C-A hom Dubious 0.34256727484796 0.365962012409731 no 1687 0.341059723959271 1130 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YDL062W_d YDL062W YDL062W hom Dubious 0.342566687026241 0.365962233552631 no 1688 0.37209128113079 1231 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YDL063C; YDL062W is not essential Unknown Unknown Unknown
YHR198C YHR198C AIM18 hom Verified 0.341954113938849 0.366192712292601 no 1689 0.363914738949615 1246 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss biological_process molecular_function mitochondrion
YOR144C YOR144C ELG1 hom Verified 0.341725767804863 0.366278639181152 no 1690 0.360515702366788 1200 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS|MITOCHONDRION|CHROMOSOME Subunit of an alternative replication factor C complex important for DNA replication and genome integrity; suppresses spontaneous DNA damage; involved in homologous recombination-mediated repair and telomere homeostasis; required for PCNA (Pol30p) unloading during DNA replication negative regulation of DNA recombination|negative regulation of transposition, RNA-mediated|telomere maintenance|double-strand break repair via homologous recombination|DNA-dependent DNA replication|mitotic sister chromatid cohesion chromatin binding Elg1 RFC-like complex|mitochondrion|nucleus|cytoplasm
YAR042W YAR042W SWH1 hom Verified 0.341192872415421 0.366479194348976 no 1691 0.360947018618373 1201 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats; localizes to the Golgi and the nucleus-vacuole junction endocytosis|maintenance of cell polarity|exocytosis|sterol transport lipid binding|oxysterol binding|1-phosphatidylinositol binding|sterol transporter activity nuclear envelope|endoplasmic reticulum|Golgi trans cisterna|early endosome
YJR111C_p YJR111C YJR111C hom Uncharacterized 0.341133919815287 0.366501383399968 no 1692 0.358415700012456 1204 NA FT OXIDATION-REDUCTION PROCESS MITOCHONDRION Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria biological_process molecular_function mitochondrion
YNR002C YNR002C ATO2 hom Verified 0.340346107395858 0.366797949337684 no 1693 0.342638247669028 1136 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION|PLASMA MEMBRANE Putative transmembrane protein involved in export of ammonia; ammonia is a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Y. lipolytica Gpr1p; ATO2 has a paralog, ADY2, that arose from the whole genome duplication ammonium transport|nitrogen utilization ammonium transmembrane transporter activity mitochondrion|integral to membrane|plasma membrane
YHR152W YHR152W SPO12 hom Verified 0.338391670317365 0.367534025206592 no 1694 0.365220483743088 1203 NA FT CELL CYCLE NUCLEUS Nucleolar protein of unknown function, positive regulator of mitotic exit; involved in regulating release of Cdc14p from the nucleolus in early anaphase, may play similar role in meiosis regulation of exit from mitosis|mitotic cell cycle|meiosis I molecular_function nucleolus|nucleus
YJR092W YJR092W BUD4 hom Verified 0.33745988662045 0.367885123148658 no 1695 0.363252421475353 1200 NA FT CELL CYCLE|CELL DIVISION SITE OF POLARIZED GROWTH|CYTOSKELETON Anillin-like protein involved in bud-site selection; required for the axial budding pattern; localizes with septins to the bud neck in mitosis and may constitute an axial landmark for the next round of budding; required for the formation and disassembly of the double septin ring structure, and generally for septin organization; in vivo substrate of Cdc28p/Clb2p cellular bud site selection|axial cellular bud site selection GTP binding cellular bud neck contractile ring
YOR264W YOR264W DSE3 hom Verified 0.33718571081066 0.367988454173771 no 1696 0.35555069824391 1187 NA FT CELL CYCLE SITE OF POLARIZED GROWTH Daughter cell-specific protein, may help establish daughter fate; relocalizes from bud neck to cytoplasm upon DNA replication stress biological_process molecular_function cellular bud neck
YDR422C YDR422C SIP1 hom Verified 0.336979111375623 0.368066323413904 no 1697 0.369442090367394 1189 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|SIGNALING|PROTEIN PHOSPHORYLATION Alternate beta-subunit of the Snf1p kinase complex, may confer substrate specificity; vacuolar protein containing KIS (Kinase-Interacting Sequence) and ASC (Association with Snf1 kinase Complex) domains involved in protein interactions signal transduction|protein phosphorylation|regulation of protein complex assembly AMP-activated protein kinase activity AMP-activated protein kinase complex|fungal-type vacuole
YMR205C YMR205C PFK2 hom Verified 0.335698620484844 0.36854907310511 no 1698 0.492104650705669 1643 NA FT CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes proton transport|glycolysis mRNA binding|6-phosphofructokinase activity mitochondrion|6-phosphofructokinase complex|cytoplasm
YIL137C YIL137C TMA108 hom Verified 0.335490240686199 0.368627652697268 no 1699 0.363091165555471 1180 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RIBOSOME BIOGENESIS|PROTEOLYSIS Protein that associates with ribosomes and is involved in ribosome biogenesis; putative metalloprotease ribosome biogenesis molecular_function ribosome|cytoplasm
YLR134W YLR134W PDC5 hom Verified 0.335353030939863 0.36867939720933 no 1700 0.366916839518436 1202 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Minor isoform of pyruvate decarboxylase, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde, regulation is glucose- and ethanol-dependent, repressed by thiamine, involved in amino acid catabolism L-phenylalanine catabolic process|glucose catabolic process to ethanol|pyruvate metabolic process|tryptophan catabolic process|aromatic amino acid family catabolic process to alcohol via Ehrlich pathway pyruvate decarboxylase activity nucleus|cytoplasm
YDR518W YDR518W EUG1 hom Verified 0.335334410875188 0.368686419387893 no 1701 0.361701458682154 1206 NA FT ENDOPLASMIC RETICULUM Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER protein folding protein disulfide isomerase activity|protein disulfide oxidoreductase activity endoplasmic reticulum
YPL112C YPL112C PEX25 hom Verified 0.335271020398401 0.368710326145232 no 1702 0.374443606301827 1254 NA FT PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with homologous protein Pex27p protein import into peroxisome matrix|peroxisome organization molecular_function peroxisomal membrane
YNL031C YNL031C HHT2 hom Verified 0.334591553596944 0.368966608642572 no 1703 0.359204449396912 1175 NA FT CELL CYCLE|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE NUCLEUS|CHROMOSOME Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT1); regulated by acetylation, methylation, and phosphorylation chromatin assembly or disassembly|global genome nucleotide-excision repair|rRNA transcription|sexual sporulation resulting in formation of a cellular spore|mitotic cell cycle spindle assembly checkpoint DNA binding nuclear nucleosome
YDL018C YDL018C ERP3 hom Verified 0.333798266518838 0.369265895797214 no 1704 0.377940776174326 1243 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport vesicle-mediated transport molecular_function integral to membrane
YOL036W_p YOL036W YOL036W hom Uncharacterized 0.333476286893625 0.369387393191284 no 1705 0.372246894726288 1227 NA Protein of unknown function; potential Cdc28p substrate; YOL036W has a paralog, YIR016W, that arose from the whole genome duplication biological_process molecular_function cellular_component
YNR040W_p YNR040W YNR040W hom Uncharacterized 0.331971513562142 0.369955384627504 no 1706 0.374278757131109 1220 NA FT MITOCHONDRION Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process molecular_function mitochondrion
YGR041W YGR041W BUD9 hom Verified 0.330561882898001 0.370487721010901 no 1707 0.355321955160613 1195 NA FT CELL CYCLE|CELL DIVISION SITE OF POLARIZED GROWTH|PLASMA MEMBRANE Protein involved in bud-site selection; mutant has increased aneuploidy tolerance; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the distal pole cellular bud site selection molecular_function plasma membrane|cellular bud neck
YBR212W YBR212W NGR1 hom Verified 0.329871264010353 0.370748618636319 no 1708 0.382800489474611 1271 NA FT MITOCHONDRION ORGANIZATION RNA binding protein that negatively regulates growth rate; interacts with the 3' UTR of the mitochondrial porin (POR1) mRNA and enhances its degradation; overexpression impairs mitochondrial function; interacts with Dhh1p to mediate POR1 mRNA decay; expressed in stationary phase 3'-UTR-mediated mRNA destabilization|mitochondrion organization mRNA binding cytoplasmic mRNA processing body|cytoplasmic stress granule|perinuclear region of cytoplasm|cytoplasm
YFL004W YFL004W VTC2 hom Verified 0.329870054860511 0.370749075473442 no 1709 0.366842954950774 1252 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT ENDOPLASMIC RETICULUM Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion polyphosphate metabolic process|vacuolar transport|microautophagy|protein localization|vacuole fusion, non-autophagic molecular_function fungal-type vacuole membrane|integral to membrane|endoplasmic reticulum|vacuolar transporter chaperone complex
YKL103C YKL103C APE1 hom Verified 0.328827294344225 0.37114311568735 no 1710 0.35089084621687 1179 NA Vacuolar aminopeptidase yscI; zinc metalloproteinase that belongs to the peptidase family M18; often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway; protein increases in abundance and relative distribution to cytoplasmic foci increases upon DNA replication stress vacuolar protein catabolic process metalloaminopeptidase activity fungal-type vacuole
YNL086W_p YNL086W SNN1 hom Uncharacterized 0.325715903452346 0.37231965531966 no 1711 0.360508418251159 1200 NA Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to endosomes biological_process molecular_function endosome|BLOC-1 complex
YGL124C YGL124C MON1 hom Verified 0.325495335565872 0.372403106139795 no 1712 0.381839700003074 1255 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT Protein required for fusion of cvt-vesicles and autophagosomes with the vacuole; associates, as a complex with Ccz1p, with a perivacuolar compartment; potential Cdc28p substrate autophagy|vesicle docking|protein targeting to vacuole molecular_function cytosol|fungal-type vacuole membrane|Mon1-Ccz1 complex
YNL220W YNL220W ADE12 hom Verified 0.324862577161967 0.372642540535143 no 1713 0.368870541348291 1230 NA FT NUCLEOTIDE METABOLISM Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence purine nucleotide biosynthetic process DNA replication origin binding|adenylosuccinate synthase activity cytoplasm
YOR346W YOR346W REV1 hom Verified 0.324752030364511 0.372684376254795 no 1714 0.350444937727821 1138 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION|CHROMOSOME Deoxycytidyl transferase; involved in repair of abasic sites and adducted guanines in damaged DNA by translesion synthesis (TLS); forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; relocalizes from nucleus to cytoplasm upon DNA replication stress error-prone translesion synthesis|error-free translesion synthesis deoxycytidyl transferase activity|DNA-directed DNA polymerase activity nuclear chromatin|mitochondrion|replication fork
YDL115C YDL115C IWR1 hom Verified 0.323343832886119 0.373217430740365 no 1715 0.376226682368296 1268 NA FT PROTEIN LOCALIZATION NUCLEUS RNA POL II, HOLOENZYME RNA polymerase II transport factor, conserved from yeast to humans; also has a role in transporting RNA polymerase III into the nucleus; interacts with most of the RNAP II subunits; nucleo-cytoplasmic shuttling protein; deletion causes hypersensitivity to K1 killer toxin; protein increases in abundance and relocalizes from nucleus to cytoplasm upon DNA replication stress cellular protein complex localization|nucleocytoplasmic transport protein binding nucleus|DNA-directed RNA polymerase II, holoenzyme|cytoplasm
YOL105C YOL105C WSC3 hom Verified 0.322457945372024 0.373552896176344 no 1716 0.358560951806121 1230 NA FT SIGNALING|CELL WALL ORG/BIOGENESIS|CYTOSKELETON ORGANIZATION|PEROXISOME ORGANIZATION SITE OF POLARIZED GROWTH Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity; involved in the response to heat shock and other stressors; regulates 1,3-beta-glucan synthesis response to heat|peroxisome degradation|Rho protein signal transduction transmembrane signaling receptor activity mating projection tip
YLR107W YLR107W REX3 hom Verified 0.321443342070331 0.373937221080402 no 1717 0.368309108029726 1220 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS RNA exonuclease; required for maturation of the RNA component of RNase MRP; functions redundantly with Rnh70p and Rex2p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases U5 snRNA 3'-end processing|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ncRNA 3'-end processing 3'-5'-exoribonuclease activity|3'-5' exonuclease activity nucleus|cytoplasm
YDR034C YDR034C LYS14 hom Verified 0.320963181493375 0.374119146400507 no 1718 0.382890261381054 1262 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|AMINO ACID METABOLISM NUCLEUS Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer Unknown|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YHR203C YHR203C RPS4B hom Verified 0.320836918528356 0.374166990117418 no 1719 0.393396544859284 1294 NA FT TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4B has a paralog, RPS4A, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic small ribosomal subunit|90S preribosome
YGL250W YGL250W RMR1 hom Verified 0.320410395877581 0.37432862292929 no 1720 0.368131334338463 1250 NA FT CELL CYCLE NUCLEUS Protein required for meiotic recombination and gene conversion; null mutant displays reduced PIS1 expression and growth defects on non-fermentable carbon sources and minimal media; GFP-fusion protein localizes to both cytoplasm and nucleus meiotic gene conversion|reciprocal meiotic recombination molecular_function nucleus|cytoplasm
YER046W YER046W SPO73 hom Verified 0.31982950201018 0.374548790982109 no 1721 0.366191819062853 1222 NA FT CELL WALL ORG/BIOGENESIS Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis ascospore wall assembly|ascospore formation molecular_function cytosol
YER014W YER014W HEM14 hom Verified 0.319449239997513 0.374692938516544 no 1722 0.38810045217728 1272 NA FT OXIDATION-REDUCTION PROCESS|COFACTOR METABOLISM MITOCHONDRION Protoporphyrinogen oxidase, a mitochondrial enzyme that catalyzes the seventh step in the heme biosynthetic pathway, converting protoporphyrinogen IX to protoporphyrin IX; inhibited by diphenyl ether-type herbicides heme biosynthetic process oxygen-dependent protoporphyrinogen oxidase activity mitochondrion|mitochondrial inner membrane
YMR057C_d YMR057C YMR057C hom Dubious 0.319197582730528 0.374788344934852 no 1723 0.373443389387334 1214 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF AAC1 Unknown Unknown Unknown
YBR260C YBR260C RGD1 hom Verified 0.318062776806283 0.375218659180794 no 1724 0.364016737502228 1190 NA FT SIGNALING SITE OF POLARIZED GROWTH|CYTOSKELETON GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization response to acid|osmosensory signaling pathway Rho GTPase activator activity|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding cellular bud|mating projection tip|actin cortical patch
YJR142W_p YJR142W YJR142W hom Uncharacterized 0.317683887532576 0.375362367220929 no 1725 0.368839811635057 1237 NA Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member biological_process molecular_function cellular_component
YGL261C_p YGL261C PAU11 hom Uncharacterized 0.31753745419149 0.375417912221434 no 1726 0.377954941470477 1236 NA Putative protein of unknown function and member of the seripauperin multigene family encoded mainly in subtelomeric regions; mRNA expression appears to be regulated by SUT1 and UPC2 biological_process molecular_function cellular_component
YPL138C YPL138C SPP1 hom Verified 0.317347864914115 0.375489830940444 no 1727 0.377353503250501 1267 NA FT CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS Subunit of COMPASS (Set1C), a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; interacts with Orc2p; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein histone H3-K4 methylation|regulation of transcription, DNA-dependent|chromatin silencing at telomere histone methyltransferase activity (H3-K4 specific)|chromatin binding|methylated histone residue binding Set1C/COMPASS complex
YPL203W YPL203W TPK2 hom Verified 0.317328810957808 0.375497059099779 no 1728 0.373964272563112 1276 NA FT SIGNALING|PROTEIN PHOSPHORYLATION NUCLEUS cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk3p; localizes to P-bodies during stationary phase protein phosphorylation|Ras protein signal transduction|invasive growth in response to glucose limitation cAMP-dependent protein kinase activity|protein kinase activity nucleus|cAMP-dependent protein kinase complex
YML075C YML075C HMG1 hom Verified 0.316890089843206 0.375663500982334 no 1729 0.375133989759402 1252 NA FT LIPID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM HMG-CoA reductase; catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to the nuclear envelope; overproduction induces the formation of karmellae; forms foci at the nuclear periphery upon DNA replication stress ergosterol biosynthetic process|isopentenyl diphosphate biosynthetic process, mevalonate pathway hydroxymethylglutaryl-CoA reductase (NADPH) activity nuclear envelope|integral to membrane|endoplasmic reticulum membrane
YOL064C YOL064C MET22 hom Verified 0.316139992498171 0.37594812627469 no 1730 0.38016642453963 1265 NA FT KETONE METABOLISM|LIPID METABOLISM|AMINO ACID METABOLISM NUCLEUS Bisphosphate-3'-nucleotidase, involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway methionine biosynthetic process|hyperosmotic salinity response|sulfate assimilation 3'(2'),5'-bisphosphate nucleotidase activity cellular_component
YBR139W YBR139W YBR139W hom Verified 0.315033415871552 0.376368141241275 no 1731 0.386302211276648 1254 NA FT PROTEOLYSIS Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner phytochelatin biosynthetic process serine hydrolase activity|serine-type carboxypeptidase activity fungal-type vacuole
YFR032C-B_p YFR032C-B YFR032C-B hom Uncharacterized 0.314432494498737 0.376596289833147 no 1732 0.36291493699147 1232 NA Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YNL145W YNL145W MFA2 hom Verified 0.314152500584317 0.376702608347991 no 1733 0.363642329331091 1226 NA FT SIGNALING PLASMA MEMBRANE Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA1 pheromone-dependent signal transduction involved in conjugation with cellular fusion mating pheromone activity extracellular region
YCR102C_p YCR102C YCR102C hom Uncharacterized 0.31310653368759 0.377099862670056 no 1734 0.378679760031894 1256 NA FT OXIDATION-REDUCTION PROCESS Putative protein of unknown function, involved in copper metabolism; similar to C. carbonum toxD gene; member of the quinone oxidoreductase family response to copper ion molecular_function cellular_component
YCL075W YCL075W YCL075W hom pseudogene 0.312430088119165 0.377356843483242 no 1735 0.363983666997423 1223 NA FT NUCLEUS Pseudogene: encodes fragment of Ty Pol protein transposition, RNA-mediated ribonuclease activity|peptidase activity|RNA binding|RNA-directed DNA polymerase activity|DNA-directed DNA polymerase activity retrotransposon nucleocapsid
YDR117C YDR117C TMA64 hom Verified 0.312235826415898 0.377430653301626 no 1736 0.362607698044145 1209 NA FT TRANSLATION Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; in mammals the corresponding protein, eIF2D, has been shown to possess translation initiation factor activity biological_process RNA binding ribosome
YGR266W YGR266W YGR266W hom Verified 0.312156398433907 0.377460833287475 no 1737 0.365227150637511 1229 NA FT MITOCHONDRION|PLASMA MEMBRANE Protein of unknown function; predicted to contain a single transmembrane domain; mutant has increased aneuploidy tolerance; localized to both the mitochondrial outer membrane and the plasma membrane; protein abundance increases in response to DNA replication stress biological_process molecular_function mitochondrial outer membrane|mitochondrion|plasma membrane
YLR188W YLR188W MDL1 hom Verified 0.312061685385193 0.377496822067364 no 1738 0.385945336550665 1278 NA FT NUCLEOTIDE METABOLISM MITOCHONDRION Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, mediates export of peptides generated upon proteolysis of mitochondrial proteins, plays a role in the regulation of cellular resistance to oxidative stress oligopeptide transport|oligopeptide export from mitochondrion ATPase activity|oligopeptide-transporting ATPase activity mitochondrion|integral to membrane|mitochondrial inner membrane
YCR033W YCR033W SNT1 hom Verified 0.312032554817894 0.377507891226774 no 1739 0.377160923788869 1268 NA FT CELL CYCLE|CHROMATIN ORGANIZATION|SIGNALING NUCLEUS|CHROMOSOME Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein; mutant has increased aneuploidy tolerance negative regulation of meiosis|regulation of transcription, DNA-dependent|histone deacetylation|positive regulation of stress-activated MAPK cascade molecular_function Rpd3L-Expanded complex|Set3 complex
YML104C YML104C MDM1 hom Verified 0.309755665921034 0.378373383951706 no 1740 0.349450276259873 1150 NA FT MITOCHONDRION ORGANIZATION CYTOSKELETON Intermediate filament protein, required for nuclear and mitochondrial transmission to daughter buds; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P) nuclear migration|mitochondrion inheritance|mitochondrion organization structural constituent of cytoskeleton|phosphatidylinositol-3-phosphate binding intermediate filament|integral to membrane|cytoplasm
YER026C YER026C CHO1 hom Verified 0.308365943933065 0.378901946474625 no 1741 0.391268610311266 1301 NA FT LIPID METABOLISM ENDOPLASMIC RETICULUM|MITOCHONDRION Phosphatidylserine synthase, functions in phospholipid biosynthesis; catalyzes the reaction CDP-diaclyglycerol + L-serine = CMP + L-1-phosphatidylserine, transcriptionally repressed by myo-inositol and choline phosphatidylserine biosynthetic process CDP-diacylglycerol-serine O-phosphatidyltransferase activity mitochondrial outer membrane|integral to membrane|endoplasmic reticulum
YJR100C YJR100C AIM25 hom Verified 0.307724791060501 0.379145876986248 no 1742 0.365174247539912 1221 NA FT MITOCHONDRION Putative protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to murine NOR1; null mutant is viable and displays elevated frequency of mitochondrial genome loss biological_process molecular_function mitochondrion
YKL031W_d YKL031W YKL031W hom Dubious 0.307095979134572 0.379385159061347 no 1743 0.382783715893601 1232 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species Unknown Unknown Unknown
YEL028W_d YEL028W YEL028W hom Dubious 0.307035123515751 0.379408318930299 no 1744 0.390354256127891 1300 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOR302W YOR302W YOR302W hom Verified 0.306449228323532 0.379631315634795 no 1745 0.372609399980533 1238 NA FT TRANSLATION CPA1 uORF, Arginine attenuator peptide, regulates translation of the CPA1 mRNA regulation of translation translation regulator activity cytosol
YAL026C YAL026C DRS2 hom Verified 0.306130254685663 0.379752736558785 no 1746 0.38178502825145 1258 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|RIBOSOME BIOGENESIS|ION HOMEOSTASIS|ION HOMEOSTASIS GOLGI APPARATUS Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation and endocytosis; mutations in human homolog ATP8B1 result in liver disease intracellular protein transport|post-Golgi vesicle-mediated transport|phospholipid translocation|endocytosis|ribosomal small subunit assembly phospholipid-translocating ATPase activity trans-Golgi network|integral to membrane
YDL242W_d YDL242W YDL242W hom Dubious 0.306109463269048 0.379760651458489 no 1747 0.363010811620308 1191 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOR386W YOR386W PHR1 hom Verified 0.305920649865554 0.379832531461392 no 1748 0.399650106172994 1326 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION DNA photolyase involved in photoreactivation, repairs pyrimidine dimers in the presence of visible light; induced by DNA damage; regulated by transcriptional repressor Rph1p photoreactive repair mRNA binding|deoxyribodipyrimidine photo-lyase activity mitochondrion|nucleus
YBL063W YBL063W KIP1 hom Verified 0.305627874624296 0.379943997252074 no 1749 0.367236266323212 1217 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CELL DIVISION|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION CYTOSKELETON Kinesin-related motor protein required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; functionally redundant with Cin8p for chromosomal but not plasmid functions mitotic anaphase B|microtubule depolymerization|spindle pole body separation|plasmid partitioning|mitotic sister chromatid segregation microtubule motor activity|structural constituent of cytoskeleton spindle microtubule|kinesin complex|spindle pole body
YJR115W_p YJR115W YJR115W hom Uncharacterized 0.305007688220619 0.380180148401192 no 1750 0.363396013311091 1203 NA Putative protein of unknown function; YJR115W has a paralog, ECM13, that arose from the whole genome duplication biological_process molecular_function cellular_component
YKR016W YKR016W FCJ1 hom Verified 0.304958011343002 0.380199066021574 no 1751 0.36471237791642 1218 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial inner membrane protein, ortholog of mammalian mitofilin; involved in import of intermembrane space (IMS) proteins, probably by positioning Mia40p relative to the TOM complex to receive incoming proteins; also has an essential role in the maintenance of crista junctions and inner membrane architecture, as a component of the mitochondrial inner membrane organizing system (MICOS, MitOS or MINOS), a scaffold-like structure on the IMS side of the inner membrane cristae formation|protein import into mitochondrial intermembrane space molecular_function mitochondrion|mitochondrial inner membrane|mitochondrial crista|mitochondrial crista junction|integral to mitochondrial inner membrane
YPR072W YPR072W NOT5 hom Verified 0.304318889823529 0.380442477604192 no 1752 0.385077480924954 1270 NA FT TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation deadenylation-independent decapping of nuclear-transcribed mRNA|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|nuclear-transcribed mRNA poly(A) tail shortening|transcription elongation from RNA polymerase II promoter|protein ubiquitination ubiquitin-protein ligase activity CCR4-NOT core complex|cytoplasm
YDR256C YDR256C CTA1 hom Verified 0.30418056291818 0.380495166107658 no 1753 0.37580566997485 1224 NA FT OXIDATION-REDUCTION PROCESS|RESPONSE TO OXIDATIVE STRESS MITOCHONDRION Catalase A, breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation response to reactive oxygen species|age-dependent response to reactive oxygen species|hydrogen peroxide catabolic process catalase activity peroxisomal matrix|mitochondrial matrix
YGL234W YGL234W ADE5,7 hom Verified 0.303797765629423 0.380640984554359 no 1754 0.379566303303845 1250 NA FT NUCLEOTIDE METABOLISM Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities purine nucleobase metabolic process|purine nucleotide biosynthetic process|'de novo' IMP biosynthetic process phosphoribosylamine-glycine ligase activity|phosphoribosylformylglycinamidine cyclo-ligase activity cytoplasm
YCL022C_d YCL022C YCL022C hom Dubious 0.30333688296195 0.380816570456099 no 1755 0.344983072166868 1146 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene KCC4/YCL024W Unknown Unknown Unknown
YLR307W YLR307W CDA1 hom Verified 0.303130188782415 0.380895324252423 no 1756 0.363308594492376 1200 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM Chitin deacetylase, together with Cda2p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall ascospore wall assembly chitin deacetylase activity chitosan layer of spore wall
YML068W YML068W ITT1 hom Verified 0.302872365420262 0.380993566003129 no 1757 0.365386614677624 1243 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION Protein that modulates the efficiency of translation termination, interacts with translation release factors eRF1 (Sup45p) and eRF3 (Sup35p) in vitro, contains a zinc finger domain characteristic of the TRIAD class of proteins regulation of translational termination molecular_function cellular_component
YOL082W YOL082W ATG19 hom Verified 0.301207085196033 0.381628293682198 no 1758 0.361189196822449 1190 NA FT PROTEIN LOCALIZATION|PROTEOLYSIS|VACUOLAR TRANSPORT Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; delivers cargo proteins aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p) to the phagophore assembly site for packaging into Cvt vesicles vesicle organization|ER-associated protein catabolic process|protein processing|protein complex localization|CVT pathway protein binding, bridging pre-autophagosomal structure|cytoplasm|CVT complex|extrinsic to membrane
YGL205W YGL205W POX1 hom Verified 0.300855004175813 0.381762531493384 no 1759 0.365782800226646 1213 NA FT KETONE METABOLISM|LIPID METABOLISM|OXIDATION-REDUCTION PROCESS Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix fatty acid beta-oxidation using acyl-CoA oxidase|fatty acid beta-oxidation acyl-CoA oxidase activity peroxisomal matrix
YBL019W YBL019W APN2 hom Verified 0.300686759758882 0.381826683007197 no 1760 0.371677957530538 1245 NA FT RESPONSE TO DNA DAMAGE NUCLEUS Class II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII base-excision repair DNA-(apurinic or apyrimidinic site) lyase activity|double-stranded DNA specific 3'-5' exodeoxyribonuclease activity|phosphoric diester hydrolase activity nucleus
YER045C YER045C ACA1 hom Verified 0.300085688658225 0.382055897620967 no 1761 0.37689444273214 1255 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS ATF/CREB family basic leucine zipper (bZIP) transcription factor; binds as a homodimer to the ATF/CREB consensus sequence TGACGTCA; important for carbon source utilization; target genes include GRE2 and COS8; ACA1 has a paralog, CST6, that arose from the whole genome duplication positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YML119W_p YML119W YML119W hom Uncharacterized 0.299561547619304 0.382255809199555 no 1762 0.384601658599447 1257 NA Putative protein of unknown function; YML119W is not an essential gene; potential Cdc28p substrate biological_process molecular_function cellular_component
YOR094W YOR094W ARF3 hom Verified 0.299266022232102 0.382368538785046 no 1763 0.367191248752319 1252 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL CYCLE|LIPID METABOLISM|MEMBRANE ORGANIZATION|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION GOLGI APPARATUS|SITE OF POLARIZED GROWTH Glucose-repressible ADP-ribosylation factor, GTPase of the Ras superfamily involved in development of polarity; also has mRNA binding activity intracellular protein transport|positive regulation of phosphatidylinositol biosynthetic process|endocytosis|actin filament bundle assembly|actin cortical patch localization|cellular bud site selection mRNA binding|GTPase activity cellular bud neck|cellular bud tip
YMR007W_d YMR007W YMR007W hom Dubious 0.298102352552417 0.382812523040532 no 1764 0.358232224572245 1194 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YJR009C YJR009C TDH2 hom Verified 0.298076143547186 0.382822524549012 no 1765 0.364740222028729 1202 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY MITOCHONDRION Glyceraldehyde-3-phosphate dehydrogenase, isozyme 2; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress; TDH2 has a paralog, TDH3, that arose from the whole genome duplication gluconeogenesis|reactive oxygen species metabolic process|glycolysis|apoptotic process glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity mitochondrion|fungal-type cell wall|lipid particle|plasma membrane|cytoplasm
YGL144C YGL144C ROG1 hom Verified 0.297497307815893 0.383043431530204 no 1766 0.387515468052548 1257 NA FT LIPID METABOLISM Protein with putative serine active lipase domain; ROG1 has a paralog, YDL109C, that arose from the whole genome duplication cellular lipid metabolic process lipase activity cellular_component
YBR165W YBR165W UBS1 hom Verified 0.297336929949312 0.383104644903988 no 1767 0.369124397861497 1230 NA FT PROTEIN LOCALIZATION NUCLEUS Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity protein export from nucleus|protein ubiquitination molecular_function nucleus
YCR015C_p YCR015C YCR015C hom Uncharacterized 0.296788921477497 0.383313831992275 no 1768 0.378308141322195 1272 NA Putative protein of unknown function; YCR015C is not an essential gene biological_process molecular_function cellular_component
YKL159C YKL159C RCN1 hom Verified 0.296328378942314 0.383489657691858 no 1769 0.378068867447869 1241 NA FT SIGNALING Protein involved in calcineurin regulation during calcium signaling; has similarity to H. sapiens DSCR1 which is found in the Down Syndrome candidate region calcium-mediated signaling protein phosphatase 2B binding|calcium-dependent protein serine/threonine phosphatase regulator activity cytoplasm
YJL092W YJL092W SRS2 hom Verified 0.295409489770064 0.383840542413304 no 1770 0.393074785202262 1308 NA FT RESPONSE TO DNA DAMAGE NUCLEUS DNA helicase and DNA-dependent ATPase involved in DNA repair and checkpoint recovery, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability DNA repair|double-strand break repair via nonhomologous end joining|DNA duplex unwinding DNA helicase activity nucleus
YGR178C YGR178C PBP1 hom Verified 0.295192269783874 0.383923503425219 no 1771 0.385910387771573 1295 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|TRANSLATION NUCLEUS|MITOCHONDRION Component of glucose deprivation induced stress granules; involved in P-body-dependent granule assembly; similar to human ataxin-2; interacts with Pab1p to regulate mRNA polyadenylation; interacts with Mkt1p to regulate HO translation; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress positive regulation of translation|mRNA polyadenylation|stress granule assembly molecular_function mitochondrion|nucleus|polysome|cytoplasmic stress granule|cytoplasm
YNL146C-A_p YNL146C-A YNL146C-A hom Uncharacterized 0.295127091571613 0.383948397432259 no 1772 0.371548477179576 1228 NA Putative protein of unknown function biological_process molecular_function cellular_component
YPR013C_p YPR013C CMR3 hom Uncharacterized 0.295071291424868 0.383969709984357 no 1773 0.37844491082954 1247 NA Putative zinc finger protein; YPR013C is not an essential gene biological_process sequence-specific DNA binding cellular_component
YDL085W YDL085W NDE2 hom Verified 0.294895352958037 0.384036910989107 no 1774 0.372041963919826 1221 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY|COFACTOR METABOLISM MITOCHONDRION Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain glucose catabolic process to ethanol|NADH oxidation NADH dehydrogenase activity mitochondrion
YOL023W YOL023W IFM1 hom Verified 0.294490396828199 0.384191600237455 no 1775 0.40035114790322 1297 NA FT TRANSLATION|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial translation initiation factor 2 translational initiation|mitochondrial translational initiation|mitochondrial translation tRNA binding|GTPase activity|translation initiation factor activity mitochondrion
YGR066C_p YGR066C YGR066C hom Uncharacterized 0.294432247349643 0.384213814280162 no 1776 0.40223376797375 1317 NA Putative protein of unknown function biological_process molecular_function cellular_component
YNL311C YNL311C SKP2 hom Verified 0.294419923308634 0.384218522312298 no 1777 0.389071392277309 1262 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|PROTEOLYSIS UBIQUITIN LIGASE COMPLEX F-box protein of unknown function predicted to be part of an SCF ubiquitin protease complex; involved in regulating protein levels of sulfur metabolism enzymes; may interact with ribosomes, based on co-purification experiments SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular protein catabolic process|regulation of sulfur amino acid metabolic process ubiquitin-protein ligase activity|protein binding, bridging ribosome|SCF ubiquitin ligase complex
YGR167W YGR167W CLC1 hom Verified 0.294324228625113 0.384255080192012 no 1778 0.40328299495808 1318 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|GOLGI APPARATUS|PLASMA MEMBRANE Clathrin light chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function; two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component; YGR167W endocytosis|vesicle-mediated transport structural molecule activity clathrin vesicle coat
YBR289W YBR289W SNF5 hom Verified 0.294136950478264 0.384326628336573 no 1779 0.422796513364394 1386 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|CARBOHYDRATE METABOLISM|RESPONSE TO NUTRIENT LEVELS NUCLEUS|CHROMOSOME RSC COMPLEX Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf6p; relocates to the cytosol under hypoxic conditions sucrose catabolic process|double-strand break repair via homologous recombination|chromatin remodeling|carbon catabolite activation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II activating transcription factor binding SWI/SNF complex|nucleus
YOL018C YOL018C TLG2 hom Verified 0.294022635709712 0.384370303333038 no 1780 0.441460300697687 1423 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|LIPID METABOLISM|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT GOLGI APPARATUS Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16) inositolphosphoceramide metabolic process|Golgi to vacuole transport|endocytosis|mannosyl-inositol phosphorylceramide metabolic process|protein exit from endoplasmic reticulum|vesicle fusion|CVT pathway SNAP receptor activity SNARE complex|trans-Golgi network|integral to endosome membrane
YPR032W YPR032W SRO7 hom Verified 0.292381470966397 0.384997486807299 no 1781 0.379332178012077 1239 NA FT VESICLE-MEDIATED TRANSPORT|SIGNALING PLASMA MEMBRANE Effector of Rab GTPase Sec4p; forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lgl tumor suppressor; SRO7 has a paralog, SRO77, that arose from the whole genome duplication establishment of cell polarity|exocytosis|Golgi to plasma membrane transport|small GTPase mediated signal transduction SNARE binding|Rab GTPase binding cytosol|plasma membrane
YKL065C YKL065C YET1 hom Verified 0.2914171407625 0.385366153365826 no 1782 0.371383887092098 1237 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Endoplasmic reticulum transmembrane protein; may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein biological_process molecular_function ribosome|integral to membrane|endoplasmic reticulum|endoplasmic reticulum membrane
YMR187C_p YMR187C YMR187C hom Uncharacterized 0.291349992389341 0.385391828268649 no 1783 0.385772630003056 1279 NA Putative protein of unknown function; YMR187C is not an essential gene biological_process molecular_function integral to membrane
YAL044W-A_p YAL044W-A YAL044W-A hom Uncharacterized 0.290251455989843 0.385811936729089 no 1784 0.354908928756006 1167 NA Putative protein of unknown function; similar to S. pombe uvi31 which is a putative DNA repair protein biological_process molecular_function cellular_component
YOR321W YOR321W PMT3 hom Verified 0.2902271862351 0.385821219619355 no 1785 0.374564012462821 1249 NA FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt5p, can instead interact with Pmt1p in some conditions; antifungal drug target; PMT3 has a paralog, PMT2, that arose from the whole genome duplication protein O-linked glycosylation|protein O-linked mannosylation dolichyl-phosphate-mannose-protein mannosyltransferase activity integral to membrane|dolichyl-phosphate-mannose-protein mannosyltransferase complex
YDL107W YDL107W MSS2 hom Verified 0.289703350599307 0.386021596398676 no 1786 0.39554779767253 1309 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Peripherally bound inner membrane protein of the mitochondrial matrix involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p protein insertion into mitochondrial membrane from inner side molecular_function extrinsic to mitochondrial inner membrane|mitochondrial matrix
YHR103W YHR103W SBE22 hom Verified 0.28875621261123 0.386383971291897 no 1787 0.388800971345959 1286 NA FT PROTEIN LOCALIZATION|CELL WALL ORG/BIOGENESIS GOLGI APPARATUS Protein involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; involved in bud growth fungal-type cell wall organization molecular_function cytoplasm
YAL028W YAL028W FRT2 hom Verified 0.288631621832833 0.386431647093786 no 1788 0.354436613335302 1206 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Tail-anchored ER membrane protein of unknown function; interacts with homolog Frt1p; promotes growth in conditions of high Na+, alkaline pH, or cell wall stress, possibly via a role in posttranslational translocation; potential Cdc28p substrate; FRT2 has a paralog, FRT1, that arose from the whole genome duplication response to stress molecular_function endoplasmic reticulum
YBR235W YBR235W VHC1 hom Verified 0.288181094438978 0.38660405982944 no 1789 0.395866830731633 1287 NA Vacuolar membrane cation-chloride cotransporter (CCC); likely mediates K+ and Cl- cotransport into the vacuole; has a role in potassium homeostasis and salt tolerance; similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family transmembrane transport ion transmembrane transporter activity integral to membrane
YNL159C YNL159C ASI2 hom Verified 0.287332952151913 0.386928696883042 no 1790 0.356083945005638 1192 NA FT PROTEOLYSIS ENDOMEMBRANE SYSTEM|NUCLEUS Integral inner nuclear membrane protein that acts with Asi1p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals ubiquitin-dependent protein catabolic process molecular_function nuclear inner membrane
YBR175W YBR175W SWD3 hom Verified 0.287050549239347 0.387036807694388 no 1791 0.381389451814834 1247 NA FT CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5 histone H3-K4 methylation|telomere maintenance|chromatin silencing at telomere histone methyltransferase activity (H3-K4 specific) Set1C/COMPASS complex
YOR093C_p YOR093C YOR093C hom Uncharacterized 0.28632497296902 0.387314616382693 no 1792 0.354911857860013 1184 NA FT NUCLEUS Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents biological_process molecular_function integral to membrane
YER040W YER040W GLN3 hom Verified 0.285575202972477 0.387601749004841 no 1793 0.375135361262554 1262 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS NUCLEUS Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR), localization and activity regulated by quality of nitrogen source nitrogen catabolite activation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity cytosol|nucleus
YJR129C_p YJR129C YJR129C hom Uncharacterized 0.28512765916565 0.387773170115531 no 1794 0.378903917781523 1272 NA Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm biological_process S-adenosylmethionine-dependent methyltransferase activity cytoplasm
YGL230C_p YGL230C YGL230C hom Uncharacterized 0.28506517182145 0.387797106161613 no 1795 0.380464222830088 1267 NA Putative protein of unknown function; non-essential gene biological_process molecular_function cellular_component
YBR267W YBR267W REI1 hom Verified 0.284175721560273 0.388137860098797 no 1796 0.378024443019859 1277 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RIBOSOME BIOGENESIS|CELL DIVISION RIBOSOME Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network ribosomal large subunit biogenesis|nucleocytoplasmic transport|mitotic cell cycle|budding cell bud growth sequence-specific DNA binding cytosolic large ribosomal subunit|preribosome, large subunit precursor|cytoplasm
YPR015C_p YPR015C YPR015C hom Uncharacterized 0.283707271425209 0.38831736091094 no 1797 0.390778400495239 1281 NA Putative protein of unknown function; overexpression causes a cell cycle delay or arrest biological_process sequence-specific DNA binding cellular_component
YMR132C_p YMR132C JLP2 hom Uncharacterized 0.283679135162333 0.388328142929389 no 1798 0.376496564032936 1221 NA Protein of unknown function, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein) biological_process molecular_function cytoplasm
YNL236W YNL236W SIN4 hom Verified 0.28114843012685 0.389298278341593 no 1799 0.420408701028664 1399 NA FF|FT TRANSCRIPTION FROM RNA POL II NUCLEUS RNA POL II, HOLOENZYME Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both postive and negative transcriptional regulation; dispensible for basal transcription negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II activating transcription factor binding core mediator complex
YDL033C YDL033C SLM3 hom Verified 0.280852658384565 0.389411706404207 no 1800 0.393985744226793 1329 NA FT RNA PROCESSING|MITOCHONDRION ORGANIZATION MITOCHONDRION tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF) mitochondrial tRNA thio-modification tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity mitochondrion
YJL094C YJL094C KHA1 hom Verified 0.280366446768037 0.389598188372809 no 1801 0.383229938419791 1234 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION|GOLGI APPARATUS Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies monovalent inorganic cation transport potassium:hydrogen antiporter activity mitochondrion|integral to membrane|Golgi apparatus
YPL002C YPL002C SNF8 hom Verified 0.279693390046819 0.389856374998559 no 1802 0.389822195225125 1298 NA FF|FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|PROTEOLYSIS|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression negative regulation of transcription from RNA polymerase II promoter by glucose|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein targeting to vacuole molecular_function ESCRT II complex
YGR227W YGR227W DIE2 hom Verified 0.279559893525954 0.389907590454139 no 1803 0.389247092450956 1307 NA FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Dolichyl-phosphoglucose-dependent alpha-1,2 glucosyltransferase of the ER, functions in the pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation, has a role in regulation of ITR1 and INO1 dolichol-linked oligosaccharide biosynthetic process|protein N-linked glycosylation dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity integral to membrane|endoplasmic reticulum membrane
YLR216C YLR216C CPR6 hom Verified 0.2785229881581 0.390305460451054 no 1804 0.365057680571527 1198 NA Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity; protein abundance increases in response to DNA replication stress protein folding|protein refolding unfolded protein binding|peptidyl-prolyl cis-trans isomerase activity cytoplasm
YMR109W YMR109W MYO5 hom Verified 0.278045348024413 0.390488773989108 no 1805 0.386284214303608 1294 NA FT VESICLE-MEDIATED TRANSPORT|CELL CYCLE|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CELL DIVISION SITE OF POLARIZED GROWTH|CYTOSKELETON One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization bipolar cellular bud site selection|endocytosis|exocytosis|fungal-type cell wall organization|response to salt stress|receptor-mediated endocytosis|actin cortical patch localization|response to osmotic stress microfilament motor activity mating projection tip|actin cortical patch
YKR103W YKR103W NFT1 hom Verified 0.277808285826133 0.390579765148618 no 1806 0.396638015509912 1316 NA FT NUCLEOTIDE METABOLISM Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds. transport ATPase activity, coupled to transmembrane movement of substances integral to membrane|membrane
YBR261C YBR261C TAE1 hom Verified 0.277071623323828 0.390862555222669 no 1807 0.374768287093666 1250 NA FT TRANSLATION AdoMet-dependent proline methyltransferase; catalyzes the dimethylation of ribosomal proteins Rpl12 and Rps25 at N-terminal proline residues; has a role in protein synthesis; fusion protein localizes to the cytoplasm cytoplasmic translation|N-terminal peptidyl-proline dimethylation N-terminal protein N-methyltransferase activity cytosol|cytoplasm
YDR078C YDR078C SHU2 hom Verified 0.276446461436192 0.391102587716323 no 1808 0.395653924691085 1315 NA FT RESPONSE TO DNA DAMAGE NUCLEUS Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function recombinational repair|maintenance of rDNA|error-free translesion synthesis molecular_function Shu complex
YDR344C_d YDR344C YDR344C hom Dubious 0.276416710830267 0.391114011571802 no 1809 0.383136635619159 1273 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YIL086C_d YIL086C YIL086C hom Dubious 0.27580587321332 0.391348586224929 no 1810 0.385147425874013 1259 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YJR083C YJR083C ACF4 hom Verified 0.274998114979375 0.391658843263571 no 1811 0.381706674495716 1274 NA Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization; potential Cdc28p substrate biological_process molecular_function cellular_component
YJL127C YJL127C SPT10 hom Verified 0.274751189790797 0.39175370010642 no 1812 0.397148667815148 1313 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|RESPONSE TO DNA DAMAGE|GENE SILENCING NUCLEUS Putative histone acetylase with a role in transcriptional silencing, sequence-specific activator of histone genes, binds specifically and cooperatively to pairs of UAS elements in core histone promoters, functions at or near the TATA box DNA repair|negative regulation of transcription from RNA polymerase II promoter|chromatin silencing at rDNA|chromatin remodeling|chromatin silencing at telomere|chromatin silencing at silent mating-type cassette histone acetyltransferase activity|sequence-specific DNA binding nucleus
YOR308C YOR308C SNU66 hom Verified 0.274333185403192 0.391914292057559 no 1813 0.3905361190289 1292 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Component of the U4/U6.U5 snRNP complex involved in pre-mRNA splicing via spliceosome; also required for pre-5S rRNA processing and may act in concert with Rnh70p; has homology to human SART-1 maturation of 5S rRNA|mRNA splicing, via spliceosome molecular_function U4/U6 x U5 tri-snRNP complex
YGR133W YGR133W PEX4 hom Verified 0.274319039098063 0.391919727209777 no 1814 0.384176261020992 1250 NA FT PROTEIN LOCALIZATION|SIGNALING|PEROXISOME ORGANIZATION Peroxisomal ubiquitin conjugating enzyme required for peroxisomal matrix protein import and peroxisome biogenesis peroxisome organization|protein import into peroxisome matrix, receptor recycling|protein autoubiquitination|protein monoubiquitination|protein polyubiquitination ubiquitin-protein ligase activity peroxisome
YDR036C YDR036C EHD3 hom Verified 0.274075857864634 0.39201316317391 no 1815 0.387240702855132 1266 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION 3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis fatty acid beta-oxidation|biological_process 3-hydroxyisobutyryl-CoA hydrolase activity mitochondrion
YGR176W_d YGR176W YGR176W hom Dubious 0.273861282632781 0.392095613209809 no 1816 0.383843878802777 1281 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YGL110C YGL110C CUE3 hom Verified 0.273148398507668 0.392369572053097 no 1817 0.383402215618734 1251 NA Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination biological_process ubiquitin binding cytoplasm
YOL101C YOL101C IZH4 hom Verified 0.273032448918442 0.39241413611724 no 1818 0.408741118274943 1365 NA FT LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family; expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism; protein increases in abundance and relocalizes from nucleus to ER upon DNA replication stress cellular zinc ion homeostasis|cellular lipid metabolic process metal ion binding integral to membrane|membrane
YHR191C YHR191C CTF8 hom Verified 0.2726970699969 0.392543043589237 no 1819 0.446566242736577 1467 NA FT CELL CYCLE|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion maintenance of DNA trinucleotide repeats|mitotic sister chromatid cohesion molecular_function Ctf18 RFC-like complex
YML022W YML022W APT1 hom Verified 0.271208287091102 0.39311541979352 no 1820 0.354276469089659 1195 NA FT NUCLEOTIDE METABOLISM NUCLEUS Adenine phosphoribosyltransferase; catalyzes the formation of AMP from adenine and 5-phosphoribosylpyrophosphate; involved in the salvage pathway of purine nucleotide biosynthesis; APT1 has a paralog, APT2, that arose from the whole genome duplication AMP biosynthetic process|adenine salvage adenine phosphoribosyltransferase activity nucleus|cytoplasm
YLR211C_p YLR211C YLR211C hom Uncharacterized 0.269155859839142 0.393904872970497 no 1821 0.387518650117792 1293 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR211C is not an essential gene; ORF contains an intron biological_process molecular_function cytoplasm
YBR107C YBR107C IML3 hom Verified 0.269127630468348 0.393915734267978 no 1822 0.387881292015673 1295 NA FT PROTEIN LOCALIZATION|CELL CYCLE|CELL DIVISION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME KINETOCHORE Outer kinetochore protein and component of the Ctf19 complex; involved in the establishment of pericentromeric cohesion during mitosis; prevents non-disjunction of sister chromatids during meiosis II; required for localization of Sgo1p to pericentric sites during meiosis I; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-L and fission yeast fta1 establishment of meiotic sister chromatid cohesion|ascospore formation|protein localization to chromosome, centromeric region|meiotic sister chromatid segregation|maintenance of meiotic sister chromatid cohesion|establishment of mitotic sister chromatid cohesion molecular_function condensed nuclear chromosome outer kinetochore
YPL098C YPL098C MGR2 hom Verified 0.268564881962786 0.394132269901734 no 1823 0.421994230038331 1396 NA FT MITOCHONDRION Subunit of the TIM23 translocase complex; acts to couple Tim21p with the core Tim23 translocase; absolutely required for mitochondrial import of presequence-containing proteins at elevated temperature; required for viability of cells lacking the mitochondrial genome (petite-negative phenotype) protein import into mitochondrial matrix molecular_function mitochondrial inner membrane presequence translocase complex
YBR270C_p YBR270C BIT2 hom Uncharacterized 0.265802791814176 0.395195546492303 no 1824 0.372203125516284 1242 NA Subunit of TORC2 membrane-associated complex; involved in regulation of actin cytoskeletal dynamics during polarized growth and cell wall integrity; interacts with Slm1p and Slm2p, homologous PH domain-containing TORC2 substrates; BIT2 has a paralog, BIT61, that arose from the whole genome duplication biological_process molecular_function cellular_component
YDL046W YDL046W NPC2 hom Verified 0.265638640464415 0.395258761806364 no 1825 0.387196474701047 1269 NA Functional homolog of human NPC2/He1, which is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes intracellular sterol transport molecular_function fungal-type vacuole lumen|fungal-type vacuole
YNL299W YNL299W TRF5 hom Verified 0.265631652090981 0.39526145311695 no 1826 0.400072094205377 1330 NA FT CELL CYCLE|RNA PROCESSING|CELL DIVISION NUCLEUS Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Pap2p nuclear polyadenylation-dependent CUT catabolic process|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent snoRNA catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent snRNA catabolic process|ncRNA polyadenylation|histone mRNA catabolic process|nuclear polyadenylation-dependent mRNA catabolic process|U4 snRNA 3'-end processing|polyadenylation-dependent snoRNA 3'-end processing|snoRNA polyadenylation polynucleotide adenylyltransferase activity nucleolus|TRAMP complex
YJR024C YJR024C MDE1 hom Verified 0.26455494623771 0.395676165702919 no 1827 0.386711680450007 1269 NA FT KETONE METABOLISM|AMINO ACID METABOLISM 5'-methylthioribulose-1-phosphate dehydratase; acts in the methionine salvage pathway; potential Smt3p sumoylation substrate; expression downregulated by caspofungin and deletion mutant is caspofungin resistant L-methionine salvage from methylthioadenosine methylthioribulose 1-phosphate dehydratase activity cytoplasm
YIL112W YIL112W HOS4 hom Verified 0.263024582966414 0.396265815781894 no 1828 0.384720601356599 1264 NA FT CELL CYCLE|CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Subunit of the Set3 complex, which is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; potential Cdc28p substrate negative regulation of meiosis|histone deacetylation molecular_function Set3 complex
YIL162W YIL162W SUC2 hom Verified 0.262955846786755 0.396292305462161 no 1829 0.386313752403106 1289 NA FT CARBOHYDRATE METABOLISM MITOCHONDRION Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively sucrose catabolic process beta-fructofuranosidase activity mitochondrion|extracellular region|cytoplasm
YGR199W YGR199W PMT6 hom Verified 0.262417593072855 0.396499755252333 no 1830 0.404007813623793 1345 NA FT CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein O-mannosyltransferase, transfers mannose from dolichyl phosphate-D-mannose to protein serine/threonine residues of secretory proteins; reaction is essential for cell wall rigidity; member of a family of mannosyltransferases protein O-linked glycosylation|protein O-linked mannosylation dolichyl-phosphate-mannose-protein mannosyltransferase activity integral to membrane
YLR342W YLR342W FKS1 hom Verified 0.262333777477895 0.39653206148114 no 1831 0.397587143606207 1318 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM MITOCHONDRION|PLASMA MEMBRANE|CYTOSKELETON Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling (1->3)-beta-D-glucan biosynthetic process|positive regulation of endocytosis|regulation of cell size 1,3-beta-D-glucan synthase activity mitochondrion|1,3-beta-D-glucan synthase complex|integral to membrane|plasma membrane|cellular bud neck|cellular bud tip|actin cortical patch
YGL014W YGL014W PUF4 hom Verified 0.262145027942373 0.396604816481748 no 1832 0.411217684388948 1351 NA FT PROTEIN LOCALIZATION|CHROMATIN ORGANIZATION|TRANSLATION|GENE SILENCING Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|negative regulation of translation|protein localization|negative regulation of chromatin silencing involved in replicative cell aging mRNA binding cytoplasm
YEL012W YEL012W UBC8 hom Verified 0.261909775861926 0.396695501295289 no 1833 0.392301411576603 1289 NA FT KETONE METABOLISM|CARBOHYDRATE METABOLISM|PROTEOLYSIS Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro negative regulation of gluconeogenesis|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein polyubiquitination|protein monoubiquitination ubiquitin-protein ligase activity cytoplasm
YHR096C YHR096C HXT5 hom Verified 0.261446032543203 0.396874281117004 no 1834 0.415765884812854 1367 NA FT PLASMA MEMBRANE Hexose transporter with moderate affinity for glucose; induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs; HXT5 has a paralog, HXT3, that arose from the whole genome duplication glucose transport|hexose transport mannose transmembrane transporter activity|fructose transmembrane transporter activity|glucose transmembrane transporter activity integral to membrane|plasma membrane
YJL101C YJL101C GSH1 hom Verified 0.261048847583202 0.397027418954517 no 1835 0.388338767876027 1270 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|RESPONSE TO OXIDATIVE STRESS Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress response to cadmium ion|response to hydrogen peroxide|glutathione biosynthetic process glutamate-cysteine ligase activity intracellular
YCR081W YCR081W SRB8 hom Verified 0.261013560363697 0.397041024992543 no 1836 0.409344715286675 1352 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS NUCLEUS Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in glucose repression negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription by galactose|positive regulation of transcription from RNA polymerase II promoter RNA polymerase II transcription coactivator activity mediator complex
YEL059W_d YEL059W HHY1 hom Dubious 0.260909917613814 0.397080988264856 no 1837 0.388862003307391 1290 NA Dubious open reading frame unlikely to encode a functional protein; mutant is hypersensitive to hygromycin B indicative of defects in vacuolar trafficking Unknown Unknown Unknown
YER134C YER134C YER134C hom Verified 0.259133182202841 0.397766241640654 no 1838 0.397292713531941 1318 NA FT NUCLEUS Magnesium-dependent acid phosphatase, member of the haloacid dehalogenase superfamily; non-essential gene biological_process acid phosphatase activity nucleus|cytoplasm
YOL080C YOL080C REX4 hom Verified 0.258095167482614 0.398166730529994 no 1839 0.382769211458052 1275 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Putative RNA exonuclease possibly involved in pre-rRNA processing and ribosome assembly ribosomal large subunit assembly|rRNA processing 3'-5' exonuclease activity nucleolus|nucleus
YLR179C YLR179C YLR179C hom Verified 0.257995066396164 0.39820535740837 no 1840 0.37466447373388 1241 NA FT NUCLEUS Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus biological_process molecular_function nucleus|cytoplasm
YCL021W-A_p YCL021W-A YCL021W-A hom Uncharacterized 0.257668418228279 0.398331410919895 no 1841 0.388466046714049 1285 NA Putative protein of unknown function biological_process molecular_function cellular_component
YPR108W-A_p YPR108W-A YPR108W-A hom Uncharacterized 0.256883328490261 0.398634420381822 no 1842 0.404316346958053 1323 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YMR300C YMR300C ADE4 hom Verified 0.256371237272424 0.398832097591145 no 1843 0.406017764608573 1336 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|NUCLEOTIDE METABOLISM Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway 'de novo' IMP biosynthetic process amidophosphoribosyltransferase activity cytoplasm
YOR084W YOR084W LPX1 hom Verified 0.25624621521534 0.39888036248992 no 1844 0.37926618508536 1248 NA FT PEROXISOME ORGANIZATION Oleic acid-inducible, peroxisomal matrix localized lipase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; peroxisomal import is dependent on the PTS1 receptor, Pex5p and on self-interaction peroxisome organization lipase activity peroxisomal matrix
YDR184C YDR184C ATC1 hom Verified 0.255856952208514 0.399030647788688 no 1845 0.412603958688982 1362 NA FT CELL CYCLE|CELL DIVISION NUCLEUS Nuclear protein; possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding pattern; relative distribution to the nucleus decreases upon DNA replication stress bipolar cellular bud site selection|response to stress molecular_function nucleus
YMR133W YMR133W REC114 hom Verified 0.255669800356878 0.399102908049948 no 1846 0.370943586768822 1231 NA FT CELL CYCLE NUCLEUS|CHROMOSOME Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division meiotic DNA double-strand break formation|reciprocal meiotic recombination molecular_function condensed nuclear chromosome
YDR051C YDR051C DET1 hom Verified 0.255113110553625 0.399317869183062 no 1847 0.394526254113568 1295 NA FT NUCLEUS Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel intracellular sterol transport|dephosphorylation acid phosphatase activity nucleus|cytoplasm
YDR104C YDR104C SPO71 hom Verified 0.2545834726754 0.399522412782796 no 1848 0.378461775178885 1263 NA FT CELL WALL ORG/BIOGENESIS Meiosis-specific protein of unknown function, required for spore wall formation during sporulation, in particular for the proper size of the prospore membrane (PSM); interacts with SPO1; dispensable for both nuclear divisions during meiosis; contains two PH domains ascospore wall assembly molecular_function ascospore wall
YER121W_p YER121W YER121W hom Uncharacterized 0.253519066759899 0.399933564585313 no 1849 0.42134048603975 1358 NA Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy biological_process molecular_function cellular_component
YKL090W YKL090W CUE2 hom Verified 0.253510505253779 0.399936872118718 no 1850 0.392381495356305 1276 NA Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination biological_process ubiquitin binding cellular_component
YKL020C YKL020C SPT23 hom Verified 0.252946426423441 0.400154806309107 no 1851 0.393637383045175 1312 NA FT TRANSCRIPTION FROM RNA POL II|KETONE METABOLISM|LIPID METABOLISM|GENE SILENCING ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Mga2p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting cellular response to cold|positive regulation of unsaturated fatty acid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|chromatin silencing at silent mating-type cassette DNA binding integral to endoplasmic reticulum membrane|nucleus
YAL046C YAL046C AIM1 hom Verified 0.252487460832191 0.400332152512654 no 1852 0.405003695840512 1319 NA Protein involved in mitochondrial function or organization; null mutant displays elevated frequency of mitochondrial genome loss biological_process molecular_function cellular_component
YMR018W_p YMR018W YMR018W hom Uncharacterized 0.252397149217502 0.400367051715341 no 1853 0.412163177522257 1346 NA FT PROTEIN LOCALIZATION|PEROXISOME ORGANIZATION Putative protein of unknown function with similarity to human PEX5Rp (peroxin protein 5 related protein); transcription increases during colony development similar to genes involved in peroxisome biogenesis; YMR018W is not an essential gene biological_process molecular_function cellular_component
YMR127C YMR127C SAS2 hom Verified 0.251867977663039 0.400571555957625 no 1854 0.392482729564562 1281 NA FT CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME HISTONE ACETYLTRANSFERASE Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family histone acetylation|histone exchange|chromatin silencing at telomere acetyltransferase activity|histone acetyltransferase activity nuclear chromatin|SAS acetyltransferase complex|nuclear chromosome, telomeric region
YLL033W YLL033W IRC19 hom Verified 0.251688606917719 0.400640881968846 no 1855 0.377517757402147 1274 NA Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci mitotic recombination|ascospore formation molecular_function cellular_component
YJL063C YJL063C MRPL8 hom Verified 0.251674446230582 0.400646355146026 no 1856 0.410057265167637 1394 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial genome maintenance|mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YCR068W YCR068W ATG15 hom Verified 0.251619845842651 0.400667458654632 no 1857 0.414030843560454 1358 NA FT LIPID METABOLISM|MEMBRANE ORGANIZATION|VACUOLAR PROTEIN PROCESSING ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS Lipase required for intravacuolar lysis of autophagic bodies and Cvt bodies; targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway membrane disassembly|autophagy|piecemeal microautophagy of nucleus|vacuolar protein processing|multivesicular body membrane disassembly lipase activity integral to membrane|vacuolar lumen
YOR055W_d YOR055W YOR055W hom Dubious 0.250856811607641 0.400962408107187 no 1858 0.395152250936417 1310 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YCR049C_d YCR049C YCR049C hom Dubious 0.250191806282112 0.401219510721781 no 1859 0.416475967393613 1378 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YPL032C YPL032C SVL3 hom Verified 0.249756109425556 0.40138798190033 no 1860 0.428201808143367 1431 NA FT VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|OXIDATION-REDUCTION PROCESS SITE OF POLARIZED GROWTH Protein of unknown function; mutant phenotype suggests a potential role in vacuolar function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; relocalizes from bud neck to cytoplasm upon DNA replication stress endocytosis molecular_function cellular bud|cellular bud neck|cytoplasm
YDR409W YDR409W SIZ1 hom Verified 0.249673183666111 0.401420048933783 no 1861 0.398234165685479 1298 NA FT CHROMOSOME SEGREGATION NUCLEUS|SITE OF POLARIZED GROWTH|CHROMOSOME|CYTOSKELETON SUMO/Smt3 ligase that promotes the attachment of sumo (Smt3p; small ubiquitin-related modifier) to proteins; binds Ubc9p and may bind septins; specifically required for sumoylation of septins in vivo; localized to the septin ring protein sumoylation|chromosome segregation SUMO ligase activity nuclear chromatin|septin ring
YJR119C YJR119C JHD2 hom Verified 0.248444385092351 0.401895297740475 no 1862 0.370962029335312 1232 NA FT CHROMATIN ORGANIZATION|OXIDATION-REDUCTION PROCESS NUCLEUS JmjC domain family histone demethylase specific for H3-K4 (histone H3 Lys4); removes methyl groups specifically added by Set1p methyltransferase; protein levels regulated by Not4p (E3 ubiquitin ligase) polyubiquitin-mediated degradation histone demethylation histone demethylase activity (H3-K4 specific) nucleus|cytoplasm
YDR334W YDR334W SWR1 hom Verified 0.248213395566086 0.401984651222769 no 1863 0.419290670848436 1372 NA FF|FT CHROMATIN ORGANIZATION NUCLEUS|CHROMOSOME Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A chromatin remodeling|histone exchange structural molecule activity Swr1 complex|nucleus
YPL161C YPL161C BEM4 hom Verified 0.248063558353364 0.402042615364325 no 1864 0.467963815811703 1544 NA FF|FT SIGNALING|CYTOSKELETON ORGANIZATION NUCLEUS Protein involved in establishment of cell polarity and bud emergence; interacts with the Rho1p small GTP-binding protein and with the Rho-type GTPase Cdc42p; involved in maintenance of proper telomere length establishment of cell polarity|Rho protein signal transduction|actin cytoskeleton organization molecular_function nucleus|cytoplasm
YDR459C YDR459C PFA5 hom Verified 0.247095960159783 0.402416980070852 no 1865 0.392244232831828 1297 NA FT PLASMA MEMBRANE Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain protein palmitoylation palmitoyltransferase activity integral to membrane|plasma membrane
YLR326W_p YLR326W YLR326W hom Uncharacterized 0.24681107527949 0.402527219388057 no 1866 0.390311535826768 1257 NA Putative protein of unknown function, predicted to be palmitoylated biological_process molecular_function cellular_component
YAL068C YAL068C PAU8 hom Verified 0.246589417333495 0.402612997714494 no 1867 0.393030600436472 1315 NA FT TRANSCRIPTION FROM RNA POL II Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions ascospore formation|positive regulation of transcription from RNA polymerase II promoter molecular_function cellular_component
YMR060C YMR060C SAM37 hom Verified 0.244811306259262 0.403301269567236 no 1868 0.435945030046119 1444 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; contributes to SAM complex stability mitochondrial outer membrane translocase complex assembly|protein import into mitochondrial outer membrane|phospholipid transport molecular_function mitochondrial outer membrane|mitochondrial sorting and assembly machinery complex|mitochondrion|integral to membrane
YDR025W YDR025W RPS11A hom Verified 0.244577401626338 0.403391831801148 no 1869 0.409607780287542 1357 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11A has a paralog, RPS11B, that arose from the whole genome duplication cytoplasmic translation|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|ribosomal small subunit assembly structural constituent of ribosome cytosolic small ribosomal subunit|90S preribosome
YJL153C YJL153C INO1 hom Verified 0.244280246542296 0.403506890555963 no 1870 0.415329572204585 1357 NA FT LIPID METABOLISM|CARBOHYDRATE METABOLISM Inositol-3-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element inositol biosynthetic process inositol-3-phosphate synthase activity cytoplasm
YBR233W YBR233W PBP2 hom Verified 0.242656550374057 0.404135734640484 no 1871 0.416095060911961 1356 NA FT NUCLEUS RNA binding protein; has similarity to mammalian heterogeneous nuclear RNP K protein, involved in the regulation of telomere position effect and telomere length; relative distribution to the nucleus increases upon DNA replication stress telomere maintenance via telomere shortening mRNA binding cytoplasm
YGR054W YGR054W YGR054W hom Verified 0.241358916958357 0.404638475558624 no 1872 0.398832384372633 1326 NA FT TRANSLATION Eukaryotic initiation factor (eIF) 2A; associates specifically with both 40S subunits and 80 S ribosomes, and interacts genetically with both eIF5b and eIF4E; homologous to mammalian eIF2A translational initiation translation initiation factor activity cytosolic ribosome|cytosolic small ribosomal subunit|ribosome
YPL273W YPL273W SAM4 hom Verified 0.240840216570128 0.404839479272626 no 1873 0.398147620374236 1336 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|COFACTOR METABOLISM NUCLEUS S-adenosylmethionine-homocysteine methyltransferase, functions along with Mht1p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio homocysteine metabolic process|L-methionine biosynthetic process from S-adenosylmethionine|S-adenosylhomocysteine metabolic process homocysteine S-methyltransferase activity nucleus|cytoplasm
YPL067C_p YPL067C YPL067C hom Uncharacterized 0.240631499504824 0.404920367166413 no 1874 0.392831908120217 1280 NA Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL067C is not an essential gene biological_process molecular_function cytoplasm
YBR196C-A_p YBR196C-A YBR196C-A hom Uncharacterized 0.240509699380288 0.404967572445778 no 1875 0.433395202411535 1428 NA Putative protein of unknown function; identified by fungal homology and RT-PCR biological_process molecular_function cellular_component
YKL080W YKL080W VMA5 hom Verified 0.240267795499645 0.40506132965398 no 1876 0.477017071764958 1576 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane vacuolar acidification proton-transporting ATPase activity, rotational mechanism fungal-type vacuole membrane|vacuolar proton-transporting V-type ATPase, V1 domain|integral to membrane
YGL020C YGL020C GET1 hom Verified 0.240094728425294 0.405128410408079 no 1877 0.451176581757061 1477 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|MITOCHONDRION|GOLGI APPARATUS Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance retrograde vesicle-mediated transport, Golgi to ER|protein insertion into ER membrane protein anchor mitochondrion|integral to membrane|endoplasmic reticulum|GET complex
YLR131C YLR131C ACE2 hom Verified 0.240061604124196 0.405141249696644 no 1878 0.467726225708638 1815 NA FF|FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|CELL DIVISION NUCLEUS Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication Unknown|regulation of transcription involved in G1 phase of mitotic cell cycle RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding cytosol|nucleus
YGR051C_d YGR051C YGR051C hom Dubious 0.238374176683436 0.405795447121749 no 1879 0.399728866923416 1312 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene Unknown Unknown Unknown
YCR010C YCR010C ADY2 hom Verified 0.238141653507188 0.405885614522451 no 1880 0.41371046414782 1362 NA FT CELL CYCLE|ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION|PLASMA MEMBRANE Acetate transporter required for normal sporulation; phosphorylated in mitochondria; ADY2 has a paralog, ATO2, that arose from the whole genome duplication nitrogen utilization|ammonium transport|acetate transport|transmembrane transport acetate transmembrane transporter activity|ammonium transmembrane transporter activity mitochondrion|integral to membrane|plasma membrane
YJL077W-B_p YJL077W-B YJL077W-B hom Uncharacterized 0.237370275227814 0.406184773874696 no 1881 0.454429018564438 1502 NA Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YDR483W YDR483W KRE2 hom Verified 0.237243739302693 0.406233852834181 no 1882 0.434354616396699 1432 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Alpha1,2-mannosyltransferase of the Golgi; involved in protein mannosylation; KRE2 has a paralog, KTR6, that arose from the whole genome duplication N-glycan processing|cell wall mannoprotein biosynthetic process|protein O-linked glycosylation alpha-1,2-mannosyltransferase activity Golgi apparatus
YGR039W_d YGR039W YGR039W hom Dubious 0.236765181808487 0.406419482242795 no 1883 0.424985242426415 1424 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the Autonomously Replicating Sequence ARS722 Unknown Unknown Unknown
YER066C-A_d YER066C-A YER066C-A hom Dubious 0.236676477066443 0.406453892560078 no 1884 0.394535208723875 1310 NA Dubious open reading frame unlikely to encode a protein, partially overlaps uncharacterized ORF YER067W Unknown Unknown Unknown
YDR524C YDR524C AGE1 hom Verified 0.236653775410123 0.406462699095991 no 1885 0.354085356888441 1192 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|SIGNALING|NUCLEOTIDE METABOLISM GOLGI APPARATUS ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport phospholipid binding|ARF GTPase activator activity endosome|trans-Golgi network|cytoplasm
YMR136W YMR136W GAT2 hom Verified 0.236575494912961 0.406493066406491 no 1886 0.406079811595999 1298 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding RNA polymerase II transcription factor activity nucleus
YHL031C YHL031C GOS1 hom Verified 0.236072152817952 0.406688341056707 no 1887 0.476976044343346 1601 NA FF|FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION ENDOMEMBRANE SYSTEM|GOLGI APPARATUS v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28 Golgi vesicle transport|vesicle fusion SNAP receptor activity SNARE complex|integral to membrane|Golgi medial cisterna
YOL092W YOL092W YPQ1 hom Verified 0.235768104211138 0.406806309822068 no 1888 0.402634820080846 1331 NA Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter biological_process molecular_function fungal-type vacuole membrane|integral to membrane|cytoplasm
YGL166W YGL166W CUP2 hom Verified 0.23434580823491 0.407358263005658 no 1889 0.415605777164691 1359 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations; CUP2 has a paralog, HAA1, that arose from the whole genome duplication regulation of transcription from RNA polymerase II promoter|response to copper ion RNA polymerase II core promoter proximal region sequence-specific DNA binding|copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity|copper ion binding nucleus
YOR345C_d YOR345C YOR345C hom Dubious 0.23277771677896 0.407967008545234 no 1890 0.399427629565506 1301 NA Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2 Unknown Unknown Unknown
YOL044W YOL044W PEX15 hom Verified 0.232460203398529 0.40809029685977 no 1891 0.402572107131839 1330 NA FT PROTEIN LOCALIZATION|SIGNALING|PEROXISOME ORGANIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Phosphorylated tail-anchored type II integral peroxisomal membrane protein required for peroxisome biogenesis, cells lacking Pex15p mislocalize peroxisomal matrix proteins to cytosol, overexpression results in impaired peroxisome assembly protein import into peroxisome matrix, receptor recycling protein anchor integral to peroxisomal membrane
YLR313C YLR313C SPH1 hom Verified 0.232422275601844 0.408105024577333 no 1892 0.43257630326801 1420 NA FT CELL CYCLE|SIGNALING|CELL DIVISION|CYTOSKELETON ORGANIZATION SITE OF POLARIZED GROWTH|CYTOSKELETON Protein involved in shmoo formation and bipolar bud site selection; homologous to Spa2p, localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p bipolar cellular bud site selection|pseudohyphal growth|invasive filamentous growth|mating projection assembly molecular_function incipient cellular bud site|cellular bud neck|cellular bud tip|mating projection
YIL102C_p YIL102C YIL102C hom Uncharacterized 0.232413807562021 0.408108312813987 no 1893 0.397283982233208 1296 NA Putative protein of unknown function biological_process molecular_function cellular_component
YIL139C YIL139C REV7 hom Verified 0.232004248020043 0.408267357186909 no 1894 0.392821086377793 1291 NA FT RESPONSE TO DNA DAMAGE NUCLEUS|MITOCHONDRION|CHROMOSOME Accessory subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair error-prone translesion synthesis|error-free translesion synthesis DNA-directed DNA polymerase activity nuclear chromatin|mitochondrion|zeta DNA polymerase complex
YMR171C YMR171C EAR1 hom Verified 0.230566598702173 0.408825759421008 no 1895 0.414845827417594 1375 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|PROTEOLYSIS|VACUOLAR TRANSPORT Specificity factor required for Rsp5p-dependent ubiquitination and sorting of specific cargo proteins at the multivesicular body; mRNA is targeted to the bud via the mRNA transport system involving She2p protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway molecular_function endosome
YGL178W YGL178W MPT5 hom Verified 0.229933906876592 0.409071564120892 no 1896 0.399244919901051 1309 NA FT TRANSLATION mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity negative regulation of translation|negative regulation of translational initiation|Unknown mRNA binding|protein binding, bridging cytoplasm
YGR182C_d YGR182C YGR182C hom Dubious 0.228579416000097 0.409597912342395 no 1897 0.394652008710534 1315 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TIM13/YGR181W Unknown Unknown Unknown
YIR018W YIR018W YAP5 hom Verified 0.228127369224622 0.40977361172527 no 1898 0.404491999238928 1362 NA FT TRANSCRIPTION FROM RNA POL II|GENE SILENCING NUCLEUS|CHROMOSOME Basic leucine zipper (bZIP) iron-sensing transcription factor; YAP5 has a paralog, YAP7, that arose from the whole genome duplication negative regulation of chromatin silencing at telomere|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter in response to iron|positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding RNA polymerase II transcription factor activity nuclear chromatin|nucleus
YFL063W_d YFL063W YFL063W hom Dubious 0.228043123213603 0.409806358066835 no 1899 0.380623108427693 1265 NA Dubious open reading frame, based on available experimental and comparative sequence data Unknown Unknown Unknown
YAL017W YAL017W PSK1 hom Verified 0.228003543122448 0.40982174302654 no 1900 0.395986711140869 1309 NA FT SIGNALING|TRANSLATION|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION|GEN. OF PRECURSOR METABOLITES AND ENERGY PAS domain-containing serine/threonine protein kinase; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status; PSK1 has a paralog, PSK2, that arose from the whole genome duplication regulation of (1->6)-beta-D-glucan biosynthetic process|negative regulation of glycogen biosynthetic process|protein phosphorylation protein serine/threonine kinase activity|protein kinase activity cytoplasm
YGL034C_d YGL034C YGL034C hom Dubious 0.226610913711392 0.410363152569748 no 1901 0.422638046338447 1378 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YJR109C YJR109C CPA2 hom Verified 0.22647093657243 0.410417580649183 no 1902 0.395374979304582 1300 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Large subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor arginine biosynthetic process carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity carbamoyl-phosphate synthase complex
YML002W_p YML002W YML002W hom Uncharacterized 0.226392243500116 0.410448180066263 no 1903 0.38057058821517 1259 NA Putative protein of unknown function; expression induced by heat and by calcium shortage biological_process molecular_function cellular_component
YLR334C_d YLR334C YLR334C hom Dubious 0.226179189703514 0.410531027730621 no 1904 0.3910132680122 1292 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps a stand-alone long terminal repeat sequence whose presence indicates a retrotransposition event occurred here Unknown Unknown Unknown
YDR011W YDR011W SNQ2 hom Verified 0.224692283027214 0.411109334186422 no 1905 0.424656766226352 1418 NA FF|FT NUCLEOTIDE METABOLISM MITOCHONDRION|PLASMA MEMBRANE Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species response to drug xenobiotic-transporting ATPase activity mitochondrion|integral to membrane|plasma membrane
YLR384C YLR384C IKI3 hom Verified 0.224579567753515 0.411153180723949 no 1906 0.393304621234551 1303 NA FT PROTEIN LOCALIZATION|TRANSCRIPTION FROM RNA POL II|RNA PROCESSING NUCLEUS Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD) regulation of transcription from RNA polymerase II promoter|tRNA wobble uridine modification molecular_function Elongator holoenzyme complex|nucleus|cytoplasm
YNL242W YNL242W ATG2 hom Verified 0.223545359909764 0.411555542037516 no 1907 0.406641760239593 1337 NA FT PROTEIN LOCALIZATION|MEMBRANE ORGANIZATION|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION Peripheral membrane protein required for autophagic vesicle formation; also required for vesicle formation during pexophagy and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria; forms cytoplasmic foci upon DNA replication stress mitochondrion degradation|piecemeal microautophagy of nucleus|peroxisome degradation|CVT pathway|autophagic vacuole assembly molecular_function pre-autophagosomal structure|cytoplasm|extrinsic to membrane
YBL071W-A YBL071W-A KTI11 hom Verified 0.223448517771159 0.411593223499212 no 1908 0.456003771107042 1514 NA FT RNA PROCESSING NUCLEUS Zn-ribbon protein that co-purifies with Dph1 and Dph2 in a complex required for synthesis of diphthamide on translation factor eEF2 and with Elongator subunits Iki3p, Elp2p, and Elp3p involved in modification of wobble nucleosides in tRNAs peptidyl-diphthamide biosynthetic process from peptidyl-histidine|tRNA wobble uridine modification electron carrier activity|iron ion binding|zinc ion binding nucleus|cytoplasm
YBL001C YBL001C ECM15 hom Verified 0.223347430971542 0.411632557436436 no 1909 0.40694703130298 1325 NA FT CELL WALL ORG/BIOGENESIS NUCLEUS Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis fungal-type cell wall organization molecular_function nucleus|cytoplasm
YOL077W-A YOL077W-A ATP19 hom Verified 0.221680401872487 0.412281343792949 no 1910 0.404096124072925 1358 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS MITOCHONDRION Subunit k of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; associated only with the dimeric form of ATP synthase mitochondrial proton-transporting ATP synthase complex assembly|ATP synthesis coupled proton transport hydrogen ion transporting ATP synthase activity, rotational mechanism mitochondrion|mitochondrial proton-transporting ATP synthase complex|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
YPL241C YPL241C CIN2 hom Verified 0.21937459862864 0.413179127735154 no 1911 0.412417342464046 1372 NA FF|FT PROTEIN COMPLEX ORG/BIOGENESIS CYTOSKELETON GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2 protein folding|tubulin complex assembly|tubulin complex biogenesis GTPase activator activity cellular_component
YLR123C_d YLR123C YLR123C hom Dubious 0.218050348090504 0.413694941495628 no 1912 0.388932976860736 1323 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif Unknown Unknown Unknown
YLR300W YLR300W EXG1 hom Verified 0.21707612056135 0.414074511645478 no 1913 0.402675203070402 1311 NA FT CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM Major exo-1,3-beta-glucanase of the cell wall, involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes fungal-type cell wall organization|cellular glucan metabolic process glucan exo-1,3-beta-glucosidase activity extracellular region|fungal-type cell wall
YOL028C YOL028C YAP7 hom Verified 0.216960232856852 0.414119668165584 no 1914 0.418721558671855 1381 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Putative basic leucine zipper (bZIP) transcription factor; YAP7 has a paralog, YAP5, that arose from the whole genome duplication positive regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding nucleus
YEL060C YEL060C PRB1 hom Verified 0.215625022310665 0.414640024802393 no 1915 0.409876495529995 1334 NA FT PROTEOLYSIS|RESPONSE TO NUTRIENT LEVELS Vacuolar proteinase B (yscB); serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; activity inhibited by Pbi2p; protein abundance increases in response to DNA replication stress vacuolar protein catabolic process|sporulation resulting in formation of a cellular spore|cellular response to starvation serine-type endopeptidase activity fungal-type vacuole lumen|fungal-type vacuole
YNL206C YNL206C RTT106 hom Verified 0.21561283526947 0.414644775012717 no 1916 0.419959665077634 1386 NA FT TRANSCRIPTION FROM RNA POL II|CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Histone chaperone, involved in regulation of chromatin structure in both transcribed and silenced chromosomal regions; affects transcriptional elongation; has a role in regulation of Ty1 transposition DNA replication-independent nucleosome assembly|negative regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|DNA replication-dependent nucleosome assembly|heterochromatin assembly involved in chromatin silencing double-stranded DNA binding|histone binding nucleus
YGR069W_d YGR069W YGR069W hom Dubious 0.215264248011247 0.414780651074591 no 1917 0.42210747508228 1380 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YMR124W_p YMR124W YMR124W hom Uncharacterized 0.215171295945322 0.414816884645486 no 1918 0.408801966678313 1333 NA Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization biological_process molecular_function cytoplasm
YMR048W YMR048W CSM3 hom Verified 0.215023781714836 0.41487438853788 no 1919 0.396509783828714 1307 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Replication fork associated factor; required for stable replication fork pausing; component of the DNA replication checkpoint pathway; required for accurate chromosome segregation during meiosis; forms nuclear foci upon DNA replication stress DNA repair|DNA replication checkpoint|meiotic chromosome segregation|maintenance of DNA repeat elements|replication fork arrest|replication fork protection|mitotic sister chromatid cohesion|establishment of mitotic sister chromatid cohesion molecular_function replication fork protection complex|nucleus
YER135C_d YER135C YER135C hom Dubious 0.213095165306783 0.415626367785718 no 1920 0.409198022839209 1335 NA Dubious open reading frame unlikely to encode a protein; YER135C is not an essential gene Unknown Unknown Unknown
YDR229W YDR229W IVY1 hom Verified 0.212435523920359 0.415883637044761 no 1921 0.415805354186968 1373 NA FT MEMBRANE ORGANIZATION Phospholipid-binding protein that interacts with both Ypt7p and Vps33p, may partially counteract the action of Vps33p and vice versa, localizes to the rim of the vacuole as cells approach stationary phase vacuole fusion, non-autophagic phospholipid binding fungal-type vacuole membrane
YDR492W YDR492W IZH1 hom Verified 0.212101706305197 0.416013844275169 no 1922 0.413621461812553 1384 NA FT LIPID METABOLISM|ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc response to zinc ion|cellular zinc ion homeostasis|cellular lipid metabolic process metal ion binding integral to membrane|endoplasmic reticulum|membrane
YNR061C YNR061C YNR061C hom Verified 0.211613285720914 0.416204371776046 no 1923 0.404991474988081 1344 NA Protein of unknown function; relocalizes from vacuole to cytoplasm upon DNA replication stress biological_process molecular_function integral to membrane|fungal-type vacuole
YCR099C_p YCR099C YCR099C hom Uncharacterized 0.211034773970549 0.416430068324005 no 1924 0.460654332596182 1534 NA Putative protein of unknown function biological_process molecular_function integral to membrane
YLR177W_p YLR177W YLR177W hom Uncharacterized 0.210905273614036 0.41648059446899 no 1925 0.418119547411977 1368 NA Putative protein of unknown function; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; not an essential gene; YLR177W has a paralog, PSP1, that arose from the whole genome duplication biological_process molecular_function cytoplasm
YBR045C YBR045C GIP1 hom Verified 0.210493698707272 0.416641184601837 no 1926 0.423278157700748 1406 NA FT CELL WALL ORG/BIOGENESIS Meiosis-specific regulatory subunit of the Glc7p protein phosphatase, regulates spore wall formation and septin organization, required for expression of some late meiotic genes and for normal localization of Glc7p ascospore wall assembly|regulation of phosphoprotein phosphatase activity protein phosphatase type 1 regulator activity|protein phosphatase 1 binding protein phosphatase type 1 complex|prospore membrane
YER048C YER048C CAJ1 hom Verified 0.208416176476093 0.417452013322852 no 1927 0.409016361140604 1339 NA FT NUCLEUS Nuclear type II J heat shock protein of the E. coli dnaJ family, contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly protein folding chaperone binding nucleus
YGL158W YGL158W RCK1 hom Verified 0.208018690066267 0.417607186994999 no 1928 0.412299134334186 1357 NA FT CELL CYCLE|PROTEIN PHOSPHORYLATION Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations; RCK1 has a paralog, RCK2, that arose from the whole genome duplication protein phosphorylation|regulation of meiosis protein serine/threonine kinase activity|protein kinase activity cellular_component
YNL078W YNL078W NIS1 hom Verified 0.207600574200872 0.417770427992682 no 1929 0.393951434954373 1326 NA FT CELL CYCLE NUCLEUS|SITE OF POLARIZED GROWTH Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network regulation of mitosis molecular_function nucleus|cellular bud neck
YMR105W-A_p YMR105W-A YMR105W-A hom Uncharacterized 0.207094263636613 0.417968120973409 no 1930 0.452139062518598 1497 NA Putative protein of unknown function biological_process molecular_function cellular_component
YKL008C YKL008C LAC1 hom Verified 0.206187470965221 0.418322237151767 no 1931 0.416605871698386 1383 NA FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p replicative cell aging|ceramide biosynthetic process sphingosine N-acyltransferase activity integral to membrane|endoplasmic reticulum
YMR039C YMR039C SUB1 hom Verified 0.206006166178539 0.418393047350171 no 1932 0.402196719265962 1315 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Transcriptional coactivator; facilitates elongation through factors that modify RNAP II; role in peroxide resistance involving Rad2p; role in the hyperosmotic stress response through polymerase recruitment at RNAP II and RNAP III genes; protein abundance increases in response to DNA replication stress termination of RNA polymerase II transcription|hyperosmotic response|RNA polymerase III transcriptional preinitiation complex assembly|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase III promoter transcription coactivator activity nucleus
YJR147W YJR147W HMS2 hom Verified 0.205748614306866 0.418493641072905 no 1933 0.415752246165894 1355 NA FT NUCLEUS Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant; HMS2 has a paralog, SKN7, that arose from the whole genome duplication pseudohyphal growth molecular_function nucleus|cytoplasm
YCL076W_d YCL076W YCL076W hom Dubious 0.205523077933809 0.418581734670623 no 1934 0.400861976317994 1325 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YML019W YML019W OST6 hom Verified 0.204972601848729 0.418796765547211 no 1935 0.431282445068855 1422 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p protein N-linked glycosylation via asparagine|protein complex assembly dolichyl-diphosphooligosaccharide-protein glycotransferase activity oligosaccharyltransferase complex|integral to membrane
YGR118W YGR118W RPS23A hom Verified 0.204526115673503 0.418971192971099 no 1936 0.422049795356635 1408 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS|TRANSLATION RIBOSOME Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23A has a paralog, RPS23B, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|regulation of translational fidelity structural constituent of ribosome cytosolic small ribosomal subunit
YNR050C YNR050C LYS9 hom Verified 0.20238951047078 0.419806114078443 no 1937 0.428506261446001 1409 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, the seventh step in lysine biosynthesis pathway; exhibits genetic and physical interactions with TRM112 lysine biosynthetic process via aminoadipic acid saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity cytoplasm
YDR005C YDR005C MAF1 hom Verified 0.20066262912047 0.420481191472522 no 1938 0.42234713645774 1404 NA FT NUCLEUS Highly conserved negative regulator of RNA polymerase III; binds to the N-terminal domain of the Rpc160p subunit of Pol III to prevent closed-complex formation; localization and activity are regulated by phosphorylation, mediated by TORC1, protein kinase A, and Sch9p; localizes to cytoplasm during vegetative growth and translocates to the nucleus and nucleolus under stress conditions negative regulation of transcription from RNA polymerase III promoter RNA polymerase III core binding nucleolus|nucleus|cytoplasm
YOR015W_d YOR015W YOR015W hom Dubious 0.200549919293056 0.420525260475046 no 1939 0.415905703436962 1355 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YLR224W_p YLR224W YLR224W hom Uncharacterized 0.200548173020794 0.420525943266971 no 1940 0.413925450487751 1364 NA FT PROTEOLYSIS F-box protein and component of SCF ubiquitin ligase complexes involved in ubiquitin-dependent protein catabolism; readily monoubiquitinated in vitro by SCF-Ubc4 complexes; YLR224W is not an essential gene SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cellular response to methylmercury ubiquitin-protein ligase activity|protein binding, bridging SCF ubiquitin ligase complex
YLR168C YLR168C UPS2 hom Verified 0.200464458911469 0.420558675738838 no 1941 0.425410267872135 1411 NA FT LIPID METABOLISM|MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial protein involved in phospholipid metabolism; localizes to the intermembrane space; has a role in regulation of phospholipid metabolism by inhibiting conversion of phosphatidylethanolamine to phosphatidylcholine; null mutant has defects in mitochondrial morphology; similar to Ups1p, Ups3p and to human PRELI cristae formation|Unknown|phosphatidylethanolamine metabolic process|cardiolipin metabolic process molecular_function extrinsic to mitochondrial inner membrane|mitochondrion|mitochondrial intermembrane space
YHR149C YHR149C SKG6 hom Verified 0.199534187507018 0.42092245161161 no 1942 0.42490729995217 1402 NA FT SITE OF POLARIZED GROWTH Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p biological_process molecular_function cell cortex|incipient cellular bud site|integral to membrane|cellular bud neck|cellular bud tip
YHR061C YHR061C GIC1 hom Verified 0.199464992865001 0.420949512375599 no 1943 0.42203927079512 1385 NA FT CELL CYCLE|SIGNALING|CELL DIVISION SITE OF POLARIZED GROWTH|CYTOSKELETON Protein involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain; relocalizes from bud neck to nucleus upon DNA replication stress regulation of exit from mitosis|establishment of cell polarity|axial cellular bud site selection|Rho protein signal transduction Rho GTPase binding|Rho GTPase activator activity incipient cellular bud site|actin cap|mating projection tip|cellular bud neck|cellular bud tip
YPL029W YPL029W SUV3 hom Verified 0.199446126157296 0.420956890866099 no 1944 0.442680435362243 1472 NA FF|FT RNA PROCESSING|MITOCHONDRION ORGANIZATION MITOCHONDRION|CHROMOSOME ATP-dependent RNA helicase, component of the mitochondrial degradosome along with the RNase Dss1p; the degradosome associates with the ribosome and mediates RNA turnover; also required during splicing of the COX1 AI5_beta intron mitochondrial DNA replication|mitochondrial RNA catabolic process|Group I intron splicing exoribonuclease II activity|ATP-dependent RNA helicase activity mitochondrion|mitochondrial chromosome|mitochondrial degradosome
YMR111C YMR111C YMR111C hom Verified 0.199267096912285 0.421026907938845 no 1945 0.412902078343346 1340 NA FT NUCLEUS Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress biological_process molecular_function nucleus
YPL152W-A_p YPL152W-A YPL152W-A hom Uncharacterized 0.199205448201432 0.421051018892341 no 1946 0.419221536137182 1401 NA Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YMR035W YMR035W IMP2 hom Verified 0.198806561498762 0.421207031557177 no 1947 0.401163456448809 1323 NA FT PROTEIN LOCALIZATION|PROTEOLYSIS|MITOCHONDRION ORGANIZATION MITOCHONDRION Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p protein processing involved in protein targeting to mitochondrion endopeptidase activity mitochondrial inner membrane peptidase complex
YBR295W YBR295W PCA1 hom Verified 0.196857819899331 0.421969401278446 no 1948 0.411672506013433 1346 NA FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS PLASMA MEMBRANE Cadmium transporting P-type ATPase; may also have a role in copper and iron homeostasis; stabilized by Cd binding, which prevents ubiquitination; S288C and other lab strains contain a G970R mutation which eliminates Cd transport function cadmium ion transport|cellular iron ion homeostasis|cellular metal ion homeostasis|transmembrane transport copper-transporting ATPase activity|cadmium-exporting ATPase activity|copper ion binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism integral to membrane|plasma membrane
YNL147W YNL147W LSM7 hom Verified 0.196724414246175 0.422021601806159 no 1949 0.398605614396134 1313 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS NUCLEUS Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress nuclear-transcribed mRNA catabolic process|mRNA splicing, via spliceosome|maturation of SSU-rRNA RNA binding U6 snRNP|nucleolus|small nucleolar ribonucleoprotein complex|U4/U6 x U5 tri-snRNP complex|cytoplasm
YAR015W YAR015W ADE1 hom Verified 0.195952185320453 0.4223237954815 no 1950 0.419434790006634 1350 NA FT NUCLEOTIDE METABOLISM NUCLEUS N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase, required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine; protein abundance increases in response to DNA replication stress purine nucleotide biosynthetic process|'de novo' IMP biosynthetic process phosphoribosylaminoimidazolesuccinocarboxamide synthase activity nucleus|cytoplasm
YJL218W_p YJL218W YJL218W hom Uncharacterized 0.195878596141751 0.422352595269696 no 1951 0.425039069194706 1395 NA Putative acetyltransferase; similar to bacterial galactoside O-acetyltransferases; induced by oleate in an OAF1/PIP2-dependent manner; promoter contains an oleate response element consensus sequence; non-essential gene biological_process acetyltransferase activity cellular_component
YDR425W YDR425W SNX41 hom Verified 0.194683118023157 0.422820514448685 no 1952 0.409199272984556 1324 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT Sorting nexin, involved in the retrieval of late-Golgi SNAREs from the post-Golgi endosome to the trans-Golgi network; interacts with Snx4p retrograde transport, endosome to Golgi phosphatidylinositol binding|phosphatidylinositol-3-phosphate binding endosome
YPR045C YPR045C THP3 hom Verified 0.193746215302249 0.423187301420165 no 1953 0.401662805933785 1356 NA FT RNA PROCESSING NUCLEUS|CHROMOSOME Protein that forms a complex with Csn12p that is recruited to transcribed genes and may have a role in transcription elongation; possibly involved in splicing based on pre-mRNA accumulation defect for many intron-containing genes mRNA splicing, via spliceosome molecular_function nucleus|transcriptionally active chromatin
YKR027W YKR027W BCH2 hom Verified 0.193513553550193 0.423278396235373 no 1954 0.425135369430907 1413 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|CELL WALL ORG/BIOGENESIS|CARBOHYDRATE METABOLISM MITOCHONDRION|GOLGI APPARATUS Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; BCH2 has a paralog, CHS6, that arose from the whole genome duplication Golgi to plasma membrane transport|fungal-type cell wall chitin biosynthetic process molecular_function trans-Golgi network transport vesicle|mitochondrion|clathrin-coated vesicle|exomer complex
YBL100W-C_p YBL100W-C YBL100W-C hom Uncharacterized 0.193372919357403 0.42333346118908 no 1955 0.423318379863215 1425 NA Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YBR023C YBR023C CHS3 hom Verified 0.192881494586322 0.423525889036735 no 1956 0.450021597871188 1501 NA FT CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM SITE OF POLARIZED GROWTH Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan ascospore wall assembly|fungal-type cell wall chitin biosynthetic process|cytokinesis chitin synthase activity incipient cellular bud site|integral to membrane|chitosome|prospore membrane|cellular bud neck|mating projection tip|cytoplasm
YLR412W YLR412W BER1 hom Verified 0.19226132417308 0.423768756014743 no 1957 0.419607040440028 1428 NA FT CYTOSKELETON Protein involved in microtubule-related processes, N-acetylation; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene; similar to Arabidopsis SRR1 gene biological_process molecular_function cytoplasm
YDR368W YDR368W YPR1 hom Verified 0.192103216164987 0.423830677848781 no 1958 0.425207951001217 1423 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|RESPONSE TO OXIDATIVE STRESS NUCLEUS NADPH-dependent aldo-keto reductase; reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases; protein abundance increases in response to DNA replication stress; YPR1 has a paralog, GCY1, that arose from the whole genome duplication cellular response to oxidative stress|D-xylose catabolic process|arabinose catabolic process glucose 1-dehydrogenase (NADP+) activity|alditol:NADP+ 1-oxidoreductase activity|carbonyl reductase (NADPH) activity nucleus|cytoplasm
YEL003W YEL003W GIM4 hom Verified 0.191245554940643 0.424166607269437 no 1959 0.412255430752764 1337 NA FT PROTEIN COMPLEX ORG/BIOGENESIS Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it tubulin complex assembly tubulin binding prefoldin complex|cytoplasm
YPL119C YPL119C DBP1 hom Verified 0.191033534818341 0.424249659981297 no 1960 0.423266930687287 1406 NA FT TRANSLATION Putative ATP-dependent RNA helicase of the DEAD-box protein family; mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs; protein abundance increases in response to DNA replication stress translational initiation RNA helicase activity cytoplasm
YGR262C YGR262C BUD32 hom Verified 0.189774490687859 0.424742923052419 no 1961 0.482422013631128 1603 NA FT TRANSCRIPTION FROM RNA POL II|CELL CYCLE|LIPID METABOLISM|CELL DIVISION|CARBOHYDRATE METABOLISM|PROTEIN PHOSPHORYLATION NUCLEUS|CHROMOSOME Protein kinase, component of the EKC/KEOPS complex with Kae1p, Cgi121p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription threonylcarbamoyladenosine metabolic process|protein phosphorylation|telomere maintenance|cellular bud site selection|positive regulation of transcription from RNA polymerase II promoter protein serine/threonine kinase activity EKC/KEOPS complex|nucleus|cytoplasm
YGR008C YGR008C STF2 hom Verified 0.189015279421575 0.425040420700476 no 1962 0.429363661072243 1436 NA FT MITOCHONDRION Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress cellular response to desiccation molecular_function cytoplasm
YLR433C YLR433C CNA1 hom Verified 0.188940459866577 0.425069741127179 no 1963 0.411203190821298 1364 NA FT SIGNALING|ION HOMEOSTASIS|CELL WALL ORG/BIOGENESIS|ION HOMEOSTASIS Calcineurin A; one isoform (the other is CMP2) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1 adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion|fungal-type cell wall organization|cellular ion homeostasis calcium-dependent protein serine/threonine phosphatase activity calcineurin complex|cytoplasm
YLR364W YLR364W GRX8 hom Verified 0.187997204472732 0.425439421308809 no 1964 0.400477739758152 1315 NA FT OXIDATION-REDUCTION PROCESS|GEN. OF PRECURSOR METABOLITES AND ENERGY Glutaredoxin that employs a dithiol mechanism of catalysis; monomeric; activity is low and null mutation does not affect sensitivity to oxidative stress; GFP-fusion protein localizes to the cytoplasm; expression strongly induced by arsenic biological_process glutathione-disulfide reductase activity cytoplasm
YMR095C YMR095C SNO1 hom Verified 0.18799363024035 0.425440822245059 no 1965 0.410883632990872 1373 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Protein of unconfirmed function, involved in pyridoxine metabolism; expression is induced during stationary phase; forms a putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminase pyridoxine metabolic process|thiamine biosynthetic process|anti-apoptosis molecular_function cytoplasm
YMR271C YMR271C URA10 hom Verified 0.187803565045401 0.425515320497539 no 1966 0.40979841697824 1352 NA FT NUCLEOTIDE METABOLISM Minor orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA10 has a paralog, URA5, that arose from the whole genome duplication 'de novo' pyrimidine nucleobase biosynthetic process|pyrimidine ribonucleoside biosynthetic process orotate phosphoribosyltransferase activity cytoplasm
YPL240C YPL240C HSP82 hom Verified 0.18766192606806 0.425570839263066 no 1967 0.43785361782605 1453 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|MITOCHONDRION ORGANIZATION Hsp90 chaperone; redundant in function with Hsc82p; required for pheromone signaling, negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding, nucleotide addition; protein abundance increases in response to DNA replication stress; contains two acid-rich unstructured regions that promote solubility of chaperone-substrate complexes; HSP82 has a paralog, HSC82, that arose from the whole genome duplication proteasome assembly|positive regulation of telomere maintenance via telomerase|box C/D snoRNP assembly|response to stress|protein refolding|protein targeting to mitochondrion|response to osmotic stress|'de novo' protein folding unfolded protein binding|ATPase activity, coupled cytoplasm
YDR065W YDR065W RRG1 hom Verified 0.186771643651511 0.425919840374567 no 1968 0.419393332922293 1380 NA FT ION HOMEOSTASIS|MITOCHONDRION ORGANIZATION|ION HOMEOSTASIS MITOCHONDRION Protein of unknown function, required for vacuolar acidification and mitochondrial genome maintenance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies mitochondrial genome maintenance|vacuolar acidification molecular_function mitochondrion
YIR030C YIR030C DCG1 hom Verified 0.18632735033201 0.426094030273149 no 1969 0.423167756997211 1403 NA Protein of unknown function, expression is sensitive to nitrogen catabolite repression and regulated by Dal80p; contains transmembrane domain nitrogen compound metabolic process molecular_function cellular_component
YER183C YER183C FAU1 hom Verified 0.186257727835599 0.426121327817591 no 1970 0.429728510704977 1415 NA FT COFACTOR METABOLISM MITOCHONDRION 5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis folic acid-containing compound biosynthetic process 5-formyltetrahydrofolate cyclo-ligase activity mitochondrion
YKL023W_p YKL023W YKL023W hom Uncharacterized 0.186168645032201 0.426156255863128 no 1971 0.424979943893631 1385 NA Putative protein of unknown function, predicted by computational methods to be involved in mRNA degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm biological_process molecular_function cytoplasm
YNR060W YNR060W FRE4 hom Verified 0.185478611573696 0.426426827345688 no 1972 0.422516117208028 1395 NA FT ION HOMEOSTASIS|OXIDATION-REDUCTION PROCESS|ION HOMEOSTASIS|GEN. OF PRECURSOR METABOLITES AND ENERGY PLASMA MEMBRANE Ferric reductase, reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels siderophore transport ferric-chelate reductase activity integral to membrane|plasma membrane
YDL173W YDL173W PAR32 hom Verified 0.185473128502109 0.426428977471311 no 1973 0.437106673838427 1454 NA Putative protein of unknown function; hyperphosphorylated upon rapamycin treatment in a Tap42p-dependent manner; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; PAR32 is not an essential gene biological_process molecular_function cytoplasm
YJR020W_d YJR020W YJR020W hom Dubious 0.185406243741937 0.426455205763144 no 1974 0.426834845103289 1412 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YBR170C YBR170C NPL4 hom Verified 0.185367326998347 0.426470466784 no 1975 0.42790527468568 1434 NA FT PROTEIN LOCALIZATION|RNA LOCALIZATION ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM UBIQUITIN LIGASE COMPLEX Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; assists Cdc48p in the dislocation of misfolded, polyubiquitinated ERAD substrates that are subsequently delivered to the proteasome for degradation; also involved in the regulated destruction of resident ER membrane proteins, such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing (RUP) retrograde protein transport, ER to cytosol|proteasomal ubiquitin-dependent protein catabolic process|mitochondria-associated protein catabolic process|mitotic spindle disassembly|ER-associated protein catabolic process|ER-associated misfolded protein catabolic process|Unknown|cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process molecular_function Doa10p ubiquitin ligase complex|integral to membrane|Cdc48p-Npl4p-Ufd1p AAA ATPase complex|Cdc48p-Npl4p-Vms1p AAA ATPase complex|nuclear outer membrane-endoplasmic reticulum membrane network
YLR449W YLR449W FPR4 hom Verified 0.184849857875768 0.42667340036075 no 1976 0.425988783165148 1398 NA FT CHROMATIN ORGANIZATION|GENE SILENCING NUCLEUS|CHROMOSOME Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones histone peptidyl-prolyl isomerization|negative regulation of histone H3-K36 methylation|regulation of transcription by chromatin organization|chromatin silencing at rDNA|nucleosome assembly peptidyl-prolyl cis-trans isomerase activity|macrolide binding chromatin|nucleus
YMR090W_p YMR090W YMR090W hom Uncharacterized 0.183522532728984 0.427194020224266 no 1977 0.434744752917496 1441 NA Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; GFP-fusion protein localizes to the cytoplasm; up-regulated in response to the fungicide mancozeb; not essential for viability biological_process molecular_function cytoplasm
YEL001C YEL001C IRC22 hom Verified 0.182761475682553 0.427492588687509 no 1978 0.423594163241299 1378 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci biological_process molecular_function endoplasmic reticulum
YJR117W YJR117W STE24 hom Verified 0.181558242261487 0.427964710972777 no 1979 0.419866710777488 1380 NA FT PROTEOLYSIS ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|MITOCHONDRION Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans CAAX-box protein processing|peptide pheromone maturation metalloendopeptidase activity mitochondrial outer membrane|integral to endoplasmic reticulum membrane|integral to membrane|nuclear inner membrane
YDR107C YDR107C TMN2 hom Verified 0.180531787694778 0.428367550686728 no 1980 0.414455099188037 1356 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS|VACUOLAR TRANSPORT Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments cellular copper ion homeostasis|pseudohyphal growth|vacuolar transport|invasive growth in response to glucose limitation molecular_function fungal-type vacuole membrane|integral to membrane
YLR426W_p YLR426W TDA5 hom Uncharacterized 0.179791753257979 0.42865802903308 no 1981 0.463192087141792 1515 NA FT OXIDATION-REDUCTION PROCESS MITOCHONDRION Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele response to drug molecular_function mitochondrion|integral to membrane
YBL043W YBL043W ECM13 hom Verified 0.179781406307992 0.42866209069264 no 1982 0.407691475322671 1324 NA FT CELL WALL ORG/BIOGENESIS Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; ECM13 has a paralog, YJR115W, that arose from the whole genome duplication fungal-type cell wall organization molecular_function cellular_component
YDL089W YDL089W NUR1 hom Verified 0.178470672872597 0.429176675544326 no 1983 0.432665793277051 1436 NA FT ENDOMEMBRANE SYSTEM|NUCLEUS Protein of unknown function; interacts with Csm1p, Lrs4p; required for rDNA repeat stability; null mutant causes increase in unequal sister-chromatid exchange; GFP-fusion protein localizes to the nuclear periphery, possible Cdc28p substrate maintenance of rDNA molecular_function nuclear periphery
YDR194C YDR194C MSS116 hom Verified 0.178255184744696 0.429261286234059 no 1984 0.439210007490742 1423 NA FT RNA PROCESSING|TRANSLATION MITOCHONDRION DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing RNA folding|Group I intron splicing|Group II intron splicing RNA binding|RNA strand annealing activity|ATP-dependent RNA helicase activity mitochondrion|mitochondrial matrix
YKR034W YKR034W DAL80 hom Verified 0.178253534270745 0.42926193429966 no 1985 0.424483392275852 1389 NA FT TRANSCRIPTION FROM RNA POL II|RESPONSE TO NUTRIENT LEVELS NUCLEUS Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Gzf3p; DAL80 has a paralog, GZF3, that arose from the whole genome duplication nitrogen catabolite repression of transcription|negative regulation of transcription from RNA polymerase II promoter sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity nucleus
YMR242C YMR242C RPL20A hom Verified 0.177051012382769 0.429734160187582 no 1986 0.406965751800501 1361 NA FF|FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L20A; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20A has a paralog, RPL20B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YJR133W YJR133W XPT1 hom Verified 0.176823904551934 0.429823355899254 no 1987 0.441663353980319 1440 NA FT NUCLEOTIDE METABOLISM Xanthine-guanine phosphoribosyl transferase, required for xanthine utilization and for optimal utilization of guanine XMP salvage|hypoxanthine metabolic process xanthine phosphoribosyltransferase activity|hypoxanthine phosphoribosyltransferase activity cytoplasm
YNL266W_d YNL266W YNL266W hom Dubious 0.176387156384473 0.429994897096605 no 1988 0.425798022584848 1387 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF IST1/YNL265C Unknown Unknown Unknown
YLR044C YLR044C PDC1 hom Verified 0.175373452626944 0.430393099518483 no 1989 0.437087384340518 1436 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY NUCLEUS Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde; subject to glucose-, ethanol-, and autoregulation; involved in amino acid catabolism L-phenylalanine catabolic process|pyruvate metabolic process|glucose catabolic process to ethanol|tryptophan catabolic process|aromatic amino acid family catabolic process to alcohol via Ehrlich pathway pyruvate decarboxylase activity cytosol|nucleus|cytoplasm
YPL148C YPL148C PPT2 hom Verified 0.174955392665791 0.43055734219061 no 1990 0.447516547550955 1483 NA FF|FT KETONE METABOLISM|LIPID METABOLISM MITOCHONDRION Phosphopantetheine:protein transferase (PPTase), activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation protein-cofactor linkage holo-[acyl-carrier-protein] synthase activity mitochondrion
YDR430C YDR430C CYM1 hom Verified 0.174776247824319 0.430627726269597 no 1991 0.422633251918625 1379 NA FT PROTEOLYSIS MITOCHONDRION Lysine-specific metalloprotease of the mitochondrial intermembrane space, member of the pitrilysin family; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology proteolysis|proteolysis involved in cellular protein catabolic process metalloendopeptidase activity mitochondrion|mitochondrial intermembrane space
YCL064C YCL064C CHA1 hom Verified 0.173307211936957 0.431204977582935 no 1992 0.433631724334304 1428 NA FT KETONE METABOLISM|AMINO ACID METABOLISM MITOCHONDRION Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine threonine catabolic process|L-serine catabolic process L-threonine ammonia-lyase activity|L-serine ammonia-lyase activity mitochondrial nucleoid|mitochondrion
YNL042W-B_p YNL042W-B YNL042W-B hom Uncharacterized 0.173046191575126 0.431307559820847 no 1993 0.426606160618367 1408 NA Putative protein of unknown function biological_process molecular_function cellular_component
YDL113C YDL113C ATG20 hom Verified 0.172289581194666 0.431604937439994 no 1994 0.427117157386344 1405 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT|RESPONSE TO NUTRIENT LEVELS Sorting nexin family member required for the cytoplasm-to-vacuole targeting (Cvt) pathway and for endosomal sorting; has a Phox homology domain that binds phosphatidylinositol-3-phosphate; interacts with Snx4p; potential Cdc28p substrate mitochondrion degradation|early endosome to Golgi transport|macroautophagy|CVT pathway phosphatidylinositol-3-phosphate binding endosome|pre-autophagosomal structure|extrinsic to membrane
YOR053W_d YOR053W YOR053W hom Dubious 0.170860308627278 0.432166803392637 no 1995 0.430596159141057 1427 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VHS3/YOR054C Unknown Unknown Unknown
YGR204W YGR204W ADE3 hom Verified 0.170197244304849 0.432427509414612 no 1996 0.407854462704513 1328 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM NUCLEUS Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine purine nucleobase biosynthetic process|folic acid-containing compound metabolic process methylenetetrahydrofolate dehydrogenase (NADP+) activity|formate-tetrahydrofolate ligase activity|methenyltetrahydrofolate cyclohydrolase activity nucleus|cytoplasm
YIL127C_p YIL127C RRT14 hom Uncharacterized 0.169181710058575 0.432826857834937 no 1997 0.42267094523673 1391 NA FT NUCLEUS Putative protein of unknown function; identified in a screen for mutants with decreased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis biological_process molecular_function nucleolus
YOR106W YOR106W VAM3 hom Verified 0.168925350029687 0.432927679648381 no 1998 0.448419086882655 1485 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|MEMBRANE ORGANIZATION|RESPONSE TO NUTRIENT LEVELS Syntaxin-like vacuolar t-SNARE that functions with Vam7p in vacuolar protein trafficking; mediates docking/fusion of late transport intermediates with the vacuole; has an acidic di-leucine sorting signal and C-terminal transmembrane region autophagic vacuole fusion|vesicle fusion with vacuole|piecemeal microautophagy of nucleus|vacuole fusion, non-autophagic|vesicle docking|vesicle fusion protein homodimerization activity|SNAP receptor activity SNARE complex|fungal-type vacuole membrane
YDL171C YDL171C GLT1 hom Verified 0.168355427436999 0.433151835642679 no 1999 0.418563941003915 1382 NA FT KETONE METABOLISM|AMINO ACID METABOLISM|OXIDATION-REDUCTION PROCESS MITOCHONDRION NAD(+)-dependent glutamate synthase (GOGAT), synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source glutamate biosynthetic process|ammonia assimilation cycle glutamate synthase (NADH) activity mitochondrion
YNL321W YNL321W VNX1 hom Verified 0.167655455937649 0.4334271705363 no 2000 0.436577005789444 1442 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Calcium/H+ antiporter localized to the endoplasmic reticulum membrane; member of the calcium exchanger (CAX) family; potential Cdc28p substrate potassium ion transport|sodium ion transport|hydrogen transport potassium:hydrogen antiporter activity|sodium:hydrogen antiporter activity|calcium:hydrogen antiporter activity fungal-type vacuole membrane|integral to membrane|endoplasmic reticulum membrane|fungal-type vacuole
YOL098C_p YOL098C YOL098C hom Uncharacterized 0.167169109543348 0.433618494691373 no 2001 0.441765894517459 1455 NA FT PROTEOLYSIS Putative metalloprotease biological_process molecular_function cytoplasm
YOR214C_p YOR214C YOR214C hom Uncharacterized 0.166262926202676 0.433975020262863 no 2002 0.440067501273586 1465 NA Putative protein of unknown function; YOR214C is not an essential gene biological_process molecular_function fungal-type cell wall
YOR161C-C_p YOR161C-C YOR161C-C hom Uncharacterized 0.163894831395304 0.434906968015292 no 2003 0.433172700254037 1433 NA Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching biological_process molecular_function cellular_component
YOR051C YOR051C ETT1 hom Verified 0.163740637292649 0.434967662665329 no 2004 0.408957205565294 1332 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|TRANSLATION NUCLEUS Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts; deletion increases stop codon readthrough translational termination molecular_function nucleus
YGL109W_d YGL109W YGL109W hom Dubious 0.163623908202981 0.435013611169738 no 2005 0.42784560659843 1406 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized gene YGL108C Unknown Unknown Unknown
YPL046C YPL046C ELC1 hom Verified 0.163514353033551 0.435056736575698 no 2006 0.414290461764942 1372 NA FT RESPONSE TO DNA DAMAGE|PROTEOLYSIS NUCLEUS UBIQUITIN LIGASE COMPLEX Elongin C, conserved among eukaryotes; forms a complex with Cul3p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; plays a role in global genomic repair global genome nucleotide-excision repair|protein ubiquitination involved in ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity elongin complex|Cul3-RING ubiquitin ligase complex
YML121W YML121W GTR1 hom Verified 0.163077925040425 0.435228540189115 no 2007 0.458469718652115 1495 NA FF|FT PROTEIN LOCALIZATION|ION HOMEOSTASIS|ION HOMEOSTASIS|GENE SILENCING NUCLEUS Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB phosphate ion transport|transcription from RNA polymerase I promoter|transcription from RNA polymerase III promoter|chromatin silencing at telomere GDP binding|GTP binding fungal-type vacuole membrane|EGO complex|nucleus|late endosome membrane|cytoplasm
YBR039W YBR039W ATP3 hom Verified 0.162221727600699 0.435565625132964 no 2008 0.44958319002957 1476 NA FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS MITOCHONDRION Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis ATP synthesis coupled proton transport proton-transporting ATPase activity, rotational mechanism mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase, central stalk
YMR087W YMR087W YMR087W hom Verified 0.160872504295535 0.436096909300721 no 2009 0.437579986026884 1458 NA FT RNA PROCESSING Putative ADP-ribose-1''-monophosphatase that converts ADP-ribose-1''-monophosphate to ADP-ribose; may have a role in tRNA splicing; contains an A1pp domain tRNA splicing, via endonucleolytic cleavage and ligation phosphatase activity cellular_component
YIL092W_p YIL092W YIL092W hom Uncharacterized 0.160542135268322 0.436227016449845 no 2010 0.4388198865084 1445 NA FT NUCLEUS Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus biological_process molecular_function nucleus|cytoplasm
YOL110W YOL110W SHR5 hom Verified 0.159942756270129 0.436463083705901 no 2011 0.437235593876972 1432 NA FT PROTEIN LOCALIZATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Subunit of a palmitoyltransferase, composed of Shr5p and Erf2p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; palmitoylation is required for Ras2p membrane localization protein targeting to membrane|protein palmitoylation palmitoyltransferase activity endoplasmic reticulum palmitoyltransferase complex|extrinsic to endoplasmic reticulum membrane
YPL270W YPL270W MDL2 hom Verified 0.159766758106236 0.436532405424473 no 2012 0.432829275895339 1447 NA FT NUCLEOTIDE METABOLISM MITOCHONDRION Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, required for respiratory growth at high temperature; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis oligopeptide transport|oligopeptide export from mitochondrion oligopeptide-transporting ATPase activity mitochondrion|integral to membrane|mitochondrial inner membrane
YCL001W-A_p YCL001W-A YCL001W-A hom Uncharacterized 0.158954578515271 0.436852329919705 no 2013 0.441572598428138 1452 NA Putative protein of unknown function; YCL001W-A gene has similarity to DOM34 and is present in a region duplicated between chromosomes XIV and III biological_process molecular_function cellular_component
YMR126C_p YMR126C DLT1 hom Uncharacterized 0.15874924153573 0.436933220463741 no 2014 0.432507516926192 1439 NA Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA) biological_process molecular_function cellular_component
YDL199C_p YDL199C YDL199C hom Uncharacterized 0.158546594746986 0.437013053818039 no 2015 0.425630056540278 1420 NA Putative transporter, member of the sugar porter family transport|transmembrane transport substrate-specific transmembrane transporter activity integral to membrane|membrane
YJL095W YJL095W BCK1 hom Verified 0.158483824116657 0.437037783030239 no 2016 0.458002746539363 1514 NA FF|FT SIGNALING|PROTEIN PHOSPHORYLATION|RESPONSE TO NUTRIENT LEVELS|PEROXISOME ORGANIZATION SITE OF POLARIZED GROWTH Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p intracellular protein kinase cascade|endoplasmic reticulum unfolded protein response|peroxisome degradation|establishment of cell polarity|protein phosphorylation|response to acid|response to nutrient protein kinase activity|MAP kinase kinase kinase activity intracellular|mating projection tip
YFL020C YFL020C PAU5 hom Verified 0.158088037955348 0.437193713205281 no 2017 0.432835338977186 1436 NA Member of the seripauperin multigene family encoded mainly in subtelomeric regions; induced during alcoholic fermentation; induced by low temperature and also by anaerobic conditions; negatively regulated by oxygen and repressed by heme biological_process molecular_function integral to membrane|cytoplasm
YPR192W YPR192W AQY1 hom Verified 0.157917287096072 0.437260987928049 no 2018 0.424880849807911 1407 NA FT PLASMA MEMBRANE Spore-specific water channel that mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance ascospore formation|water transport water channel activity integral to membrane|plasma membrane
YCL001W-B_p YCL001W-B YCL001W-B hom Uncharacterized 0.156627748078789 0.437769116321864 no 2019 0.456933118504554 1518 NA Putative protein of unknown function; present in a region duplicated between chromosomes XIV and III; YCL001W-B has a paralog, DOM34, that arose from the whole genome duplication biological_process molecular_function cellular_component
YGR235C YGR235C MOS2 hom Verified 0.156019710943821 0.438008742197347 no 2020 0.461078844754112 1540 NA FT MEMBRANE ORGANIZATION|MITOCHONDRION ORGANIZATION MITOCHONDRION Mitochondrial inner membrane protein; non-essential component of the mitochondrial inner membrane organizing system (MINOS, MitOS, or MICOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture cristae formation molecular_function mitochondrion|mitochondrial crista junction|integral to mitochondrial inner membrane
YOL125W YOL125W TRM13 hom Verified 0.155468040420594 0.438226173807907 no 2021 0.4209199393791 1387 NA FT RNA PROCESSING NUCLEUS 2'-O-methyltransferase responsible for modification of tRNA at position 4; C-terminal domain has similarity to Rossmann-fold (RFM) superfamily of RNA methyltransferases tRNA methylation tRNA methyltransferase activity nucleus|cytoplasm
YER051W YER051W JHD1 hom Verified 0.154693424979846 0.438531506851259 no 2022 0.431546061857835 1421 NA FT CHROMATIN ORGANIZATION|OXIDATION-REDUCTION PROCESS NUCLEUS JmjC domain family histone demethylase specific for H3-K36, similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe histone demethylation methylated histone residue binding|histone demethylase activity (H3-K36 specific) cellular_component
YBL029C-A YBL029C-A YBL029C-A hom Verified 0.153984910833576 0.438810816545787 no 2023 0.448982230193032 1482 NA FT PLASMA MEMBRANE Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; protein abundance increases in response to DNA replication stress; has potential orthologs in Saccharomyces species and in Yarrowia lipolytica biological_process molecular_function plasma membrane
YGR079W_p YGR079W YGR079W hom Uncharacterized 0.150087061333396 0.440347963957506 no 2024 0.458992620690602 1531 NA Putative protein of unknown function; YGR079W is not an essential gene biological_process molecular_function cellular_component
YOR171C YOR171C LCB4 hom Verified 0.149020546051114 0.440768710290466 no 2025 0.424787939247003 1409 NA FT LIPID METABOLISM|SIGNALING|PROTEIN PHOSPHORYLATION ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM|GOLGI APPARATUS|PLASMA MEMBRANE Sphingoid long-chain base kinase, responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomes calcium-mediated signaling|sphingolipid metabolic process D-erythro-sphingosine kinase activity Golgi apparatus|endoplasmic reticulum|plasma membrane|cortical endoplasmic reticulum
YNL214W YNL214W PEX17 hom Verified 0.14792503193404 0.441200966451873 no 2026 0.459249919322162 1517 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|PEROXISOME ORGANIZATION Peroxisomal membrane peroxin and subunit of the docking complex that facilitates the import of peroxisomal matrix proteins; required for peroxisome biogenesis protein import into peroxisome matrix, docking protein binding peroxisomal membrane
YBR083W YBR083W TEC1 hom Verified 0.147657624516892 0.441306487846797 no 2027 0.430343831044788 1421 NA FT TRANSCRIPTION FROM RNA POL II NUCLEUS Transcription factor targeting filamentation genes and Ty1 expression; Ste12p activation of most filamentation gene promoters depends on Tec1p and Tec1p transcriptional activity is dependent on its association with Ste12p; binds to TCS elements upstream of filamentation genes, which are regulated by Tec1p/Ste12p/Dig1p complex; competes with Dig2p for binding to Ste12p/Dig1p; positive regulator of chronological life span; TEA/ATTS DNA-binding domain family member pseudohyphal growth|chronological cell aging|positive regulation of transposition, RNA-mediated|invasive growth in response to glucose limitation|positive regulation of transcription from RNA polymerase II promoter in response to stress RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific DNA binding|RNA polymerase II transcription factor recruiting transcription factor activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription nucleus
YLR070C YLR070C XYL2 hom Verified 0.147542273743066 0.441352007596303 no 2028 0.44844191566057 1479 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM Xylitol dehydrogenase, converts xylitol to D-xylulose; expression induced by xylose, even though this pentose sugar is not well utilized by S. cerevisiae; null mutant has cell wall defect xylulose biosynthetic process D-xylulose reductase activity cellular_component
YLR286C YLR286C CTS1 hom Verified 0.14676586791321 0.441658413174112 no 2029 0.416115236626139 1389 NA FT CELL WALL ORG/BIOGENESIS|CELL DIVISION|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|NUCLEUS|ENDOPLASMIC RETICULUM|SITE OF POLARIZED GROWTH Endochitinase, required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p cytokinesis, completion of separation|chitin catabolic process endochitinase activity nuclear envelope|extracellular region|fungal-type cell wall|endoplasmic reticulum|cellular bud neck
YLR309C YLR309C IMH1 hom Verified 0.146368965745426 0.441815062588352 no 2030 0.428074559761282 1407 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|GOLGI APPARATUS Protein involved in vesicular transport, mediates transport between an endosomal compartment and the Golgi, contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi Golgi to plasma membrane protein transport|vesicle-mediated transport molecular_function cytosol|Golgi apparatus
YCR107W YCR107W AAD3 hom Verified 0.145966624090384 0.441973868148843 no 2031 0.446831039746844 1472 NA FT OXIDATION-REDUCTION PROCESS Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role cellular aldehyde metabolic process aryl-alcohol dehydrogenase (NAD+) activity cellular_component
YNL241C YNL241C ZWF1 hom Verified 0.145266370453959 0.442250282765242 no 2032 0.422958436398652 1378 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|NUCLEOTIDE METABOLISM|COFACTOR METABOLISM|RESPONSE TO OXIDATIVE STRESS Glucose-6-phosphate dehydrogenase (G6PD); catalyzes the first step of the pentose phosphate pathway; involved in adapting to oxidatve stress; homolog of the human G6PD which is deficient in patients with hemolytic anemia; protein abundance increases in response to DNA replication stress NADPH regeneration|response to hydrogen peroxide|pentose-phosphate shunt, oxidative branch|carbon catabolite repression of transcription glucose-6-phosphate dehydrogenase activity cytoplasm
YFL003C YFL003C MSH4 hom Verified 0.144951030108326 0.442374767825797 no 2033 0.44279287806862 1463 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME Protein involved in meiotic recombination, required for normal levels of crossing over, colocalizes with Zip2p to discrete foci on meiotic chromosomes, has homology to bacterial MutS protein reciprocal meiotic recombination DNA binding nuclear chromosome
YDL059C YDL059C RAD59 hom Verified 0.143547936170288 0.442928727815156 no 2034 0.450350116778543 1484 NA FT RESPONSE TO DNA DAMAGE NUCLEUS Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p DNA strand renaturation|telomere maintenance via recombination|double-strand break repair via break-induced replication|double-strand break repair via single-strand annealing protein binding nucleus
YPR189W YPR189W SKI3 hom Verified 0.143453750822731 0.442965917440872 no 2035 0.424588805111055 1417 NA FT NUCLEUS Ski complex component and TPR protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, non-stop decay molecular_function Ski complex
YCR085W_d YCR085W YCR085W hom Dubious 0.14342286145416 0.442978114394994 no 2036 0.432901172751038 1415 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOL052C-A YOL052C-A DDR2 hom Verified 0.143052567250077 0.443124332704521 no 2037 0.442399732490078 1453 NA Multi-stress response protein; expression is activated by a variety of xenobiotic agents and environmental or physiological stresses; DDR2 has a paralog, HOR7, that arose from the whole genome duplication response to stress molecular_function fungal-type vacuole|cytoplasm
YCL045C YCL045C EMC1 hom Verified 0.142599813085604 0.443303122554385 no 2038 0.438721456586844 1432 NA FT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Member of conserved endoplasmic reticulum membrane complex; involved in efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; interacts with Gal80p; homologous to worm H17B01.4/EMC-1, fly CG2943, and human KIAA0090 protein folding in endoplasmic reticulum molecular_function ER membrane protein complex|endoplasmic reticulum
YHR127W YHR127W YHR127W hom Verified 0.142190797856734 0.443464650091762 no 2039 0.444670137767653 1458 NA FT CELL CYCLE|CYTOSKELETON ORGANIZATION NUCLEUS Protein of unknown function; localizes to the nucleus; required for asymmetric localization of Kar9p during mitosis mitotic spindle elongation molecular_function nucleus
YLR046C_p YLR046C YLR046C hom Uncharacterized 0.141604989137505 0.443696012943597 no 2040 0.428191326057031 1411 NA Putative membrane protein; member of the fungal lipid-translocating exporter (LTE) family of proteins; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance biological_process molecular_function integral to membrane
YPR160W YPR160W GPH1 hom Verified 0.141532932406978 0.443724472793367 no 2041 0.423180269618322 1395 NA FT OXIDATION-REDUCTION PROCESS|CARBOHYDRATE METABOLISM|GEN. OF PRECURSOR METABOLITES AND ENERGY Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway glycogen catabolic process glycogen phosphorylase activity cytoplasm
YBR195C YBR195C MSI1 hom Verified 0.140826930967021 0.444003333622477 no 2042 0.444435680055502 1466 NA FT CHROMATIN ORGANIZATION NUCLEUS Subunit of chromatin assembly factor I (CAF-1); chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription; Msi1p localizes to both nucleus and cytoplasm and has an independent role as a negative regulator of the RAS/cAMP pathway via sequestration of Npr1p kinase DNA replication-dependent nucleosome assembly histone binding nucleus|CAF-1 complex|cytoplasm
YHL038C YHL038C CBP2 hom Verified 0.140514726767771 0.444126658823885 no 2043 0.401724172821957 1315 NA FT RNA PROCESSING MITOCHONDRION Required for splicing of the group I intron bI5 of the COB pre-mRNA; nuclear-encoded mitochondrial protein that binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene Group I intron splicing RNA binding mitochondrion
YMR139W YMR139W RIM11 hom Verified 0.140051608745743 0.444309607142909 no 2044 0.433447623637056 1420 NA FT PROTEOLYSIS|PROTEIN PHOSPHORYLATION Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress proteolysis|ascospore formation|protein phosphorylation|response to stress protein serine/threonine kinase activity|protein kinase activity cytoplasm
YKL202W_d YKL202W YKL202W hom Dubious 0.140029914913205 0.444318177280304 no 2045 0.420852517606107 1397 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YOR137C YOR137C SIA1 hom Verified 0.140007557986724 0.444327009399861 no 2046 0.423501606461386 1388 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS Protein of unassigned function involved in activation of the Pma1p plasma membrane H+-ATPase by glucose proton transport molecular_function cellular_component
YDR133C_d YDR133C YDR133C hom Dubious 0.139400211713124 0.444566952535306 no 2047 0.441020845716399 1433 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C Unknown Unknown Unknown
YJL038C YJL038C LOH1 hom Verified 0.139085971385285 0.444691106843383 no 2048 0.451410199233797 1504 NA Protein of unknown function with proposed roles in maintenance of genome integrity and also in spore wall assembly; induced during sporulation; repressed during vegetative growth by Sum1p and Hst1p; sequence similar to IRC1 chromosome organization molecular_function cellular_component
YDR389W YDR389W SAC7 hom Verified 0.138887099702881 0.444769682555171 no 2049 0.492033358041885 1640 NA FF|FT CELL CYCLE|SIGNALING|CYTOSKELETON ORGANIZATION CYTOSKELETON GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate actin filament reorganization involved in cell cycle|small GTPase mediated signal transduction Rho GTPase activator activity intracellular
YNL011C_p YNL011C YNL011C hom Uncharacterized 0.13775119369483 0.445218529153419 no 2050 0.413206967441737 1380 NA Putative protein of unknown function; YNL011C is not an essential gene biological_process molecular_function cellular_component
YKL051W YKL051W SFK1 hom Verified 0.137619517078316 0.445270564950096 no 2051 0.434308659865939 1439 NA FT LIPID METABOLISM|SIGNALING|CYTOSKELETON ORGANIZATION PLASMA MEMBRANE Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane vacuole organization|inositol lipid-mediated signaling|actin cytoskeleton organization molecular_function integral to membrane|plasma membrane
YGL136C YGL136C MRM2 hom Verified 0.137361015416869 0.445372722047452 no 2052 0.441619557651287 1458 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RNA PROCESSING|RIBOSOME BIOGENESIS MITOCHONDRION Mitochondrial 2' O-ribose methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ rRNA methylation rRNA (uridine-2'-O-)-methyltransferase activity mitochondrion
YGR174W-A_p YGR174W-A YGR174W-A hom Uncharacterized 0.136624338118944 0.445663868928348 no 2053 0.442660591062699 1454 NA Putative protein of unknown function; predicted to have a role in cell budding based on computational guilt by association analysis biological_process molecular_function cellular_component
YDR322W YDR322W MRPL35 hom Verified 0.135867816463657 0.445962889120995 no 2054 0.4505977912842 1491 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the large subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial large ribosomal subunit
YER162C YER162C RAD4 hom Verified 0.134497947620637 0.446504416953193 no 2055 0.449038085326255 1498 NA FT RESPONSE TO DNA DAMAGE|PROTEOLYSIS NUCLEUS Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair; subunit of Nuclear Excision Repair Factor 2 (NEF2); also involved, with Rad23p, in turnover of ubiquitylated proteins proteasomal ubiquitin-dependent protein catabolic process|nucleotide-excision repair damaged DNA binding cytosol|nucleotide-excision repair factor 2 complex|nucleus
YNL298W YNL298W CLA4 hom Verified 0.134208113889676 0.446619005001917 no 2056 0.491040111548883 1634 NA FF|FT CELL CYCLE|SIGNALING|CELL DIVISION|PROTEIN PHOSPHORYLATION NUCLEUS Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p negative regulation of gene expression|vacuole inheritance|protein phosphorylation|budding cell apical bud growth|Rho protein signal transduction|regulation of exit from mitosis|establishment of cell polarity|sterol import|response to pheromone|cytokinesis protein serine/threonine kinase activity|protein kinase activity nucleus|cellular bud|fungal-type vacuole
YEL071W YEL071W DLD3 hom Verified 0.133519299810115 0.446891350941524 no 2057 0.44446089407492 1457 NA FT KETONE METABOLISM|OXIDATION-REDUCTION PROCESS D-lactate dehydrogenase, part of the retrograde regulon which consists of genes whose expression is stimulated by damage to mitochondria and reduced in cells grown with glutamate as the sole nitrogen source, located in the cytoplasm lactate metabolic process|filamentous growth D-lactate dehydrogenase (cytochrome) activity cytoplasm
YBL087C YBL087C RPL23A hom Verified 0.13348659100557 0.44690428409747 no 2058 0.481087408334241 1586 NA FT TRANSLATION RIBOSOME Ribosomal 60S subunit protein L23A; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23A has a paralog, RPL23B, that arose from the whole genome duplication cytoplasmic translation structural constituent of ribosome cytosolic large ribosomal subunit
YDR130C YDR130C FIN1 hom Verified 0.133362577674343 0.446953319840218 no 2059 0.460092828321883 1532 NA FT PROTEIN LOCALIZATION|PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|CYTOSKELETON ORGANIZATION|CHROMOSOME SEGREGATION NUCLEUS|CHROMOSOME|CYTOSKELETON KINETOCHORE Spindle pole body-related intermediate filament protein; forms cell cycle-specific filaments between spindle pole bodies in dividing cells; localizes to poles and microtubules of spindle during anaphase and contributes to spindle stability; involved in Glc7p localization and regulation; relative distribution to the nucleus increases upon DNA replication stress intermediate filament cytoskeleton organization|mitotic cell cycle spindle checkpoint|mitotic spindle stabilization|mitotic sister chromatid segregation microtubule binding|structural constituent of cytoskeleton spindle microtubule|condensed nuclear chromosome kinetochore|intermediate filament|nucleus|spindle pole body|astral microtubule|spindle
YPL271W YPL271W ATP15 hom Verified 0.131484636626562 0.447695969628121 no 2060 0.471507385994424 1542 NA FT ION HOMEOSTASIS|NUCLEOTIDE METABOLISM|ION HOMEOSTASIS MITOCHONDRION Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated ATP synthesis coupled proton transport hydrogen ion transporting ATP synthase activity, rotational mechanism|ATPase activity|proton-transporting ATPase activity, rotational mechanism proton-transporting ATP synthase complex, catalytic core F(1)|mitochondrion|integral to membrane|mitochondrial proton-transporting ATP synthase, central stalk
YNL022C_p YNL022C YNL022C hom Uncharacterized 0.131457842854627 0.447706566815172 no 2061 0.43968648861022 1480 NA FT NUCLEUS Putative cytosine 5-methyltransferase, contains seven beta-strand methyltransferase motif similar to NOP2/YNL061W; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; predicted to be involved in ribosome biogenesis biological_process tRNA (cytosine-5-)-methyltransferase activity nucleus
YEL006W YEL006W YEA6 hom Verified 0.131003516436931 0.447886262833121 no 2062 0.450897993014011 1518 NA FT MITOCHONDRION Putative mitochondrial NAD+ transporter, member of the mitochondrial carrier subfamily (see also YIA6); has putative human ortholog transport|NAD transmembrane transport transporter activity|NAD transporter activity mitochondrion|integral to membrane|mitochondrial inner membrane
YOR105W_p YOR105W YOR105W hom Uncharacterized 0.130604265788995 0.448044184012092 no 2063 0.437890111378719 1462 NA Protein of unknown function; expressed at both mRNA and protein levels biological_process molecular_function cellular_component
YMR086C-A_d YMR086C-A YMR086C-A hom Dubious 0.130595909477659 0.448047489388566 no 2064 0.450429982537404 1493 NA Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Unknown Unknown Unknown
YMR100W YMR100W MUB1 hom Verified 0.130058047388947 0.448260250731307 no 2065 0.456061699196225 1492 NA FT CELL DIVISION MYND domain-containing protein required for ubiquitination and turnover of Rpn4p; interacts with Ubr2p (E3) and indirectly with Rad6p (E2); short-lived protein degraded in a Ubr2p/Rad6p dependent manner; similar to the A. nidulans samB gene regulation of cell budding|protein monoubiquitination molecular_function cellular_component
YJR150C YJR150C DAN1 hom Verified 0.129349871339225 0.448540405615564 no 2066 0.417817714418081 1379 NA Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth sterol transport molecular_function fungal-type cell wall
YMR188C YMR188C MRPS17 hom Verified 0.129275190758447 0.448569950797915 no 2067 0.440703586945343 1456 NA FT TRANSLATION|MITOCHONDRION ORGANIZATION MITOCHONDRION RIBOSOME Mitochondrial ribosomal protein of the small subunit mitochondrial translation structural constituent of ribosome mitochondrion|mitochondrial small ribosomal subunit
YMR202W YMR202W ERG2 hom Verified 0.127988371021386 0.449079087965531 no 2068 0.498145270434128 1683 NA FF|FT LIPID METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis ergosterol biosynthetic process C-8 sterol isomerase activity endoplasmic reticulum
YGR109C YGR109C CLB6 hom Verified 0.127550075536822 0.449252521124962 no 2069 0.448112545443735 1482 NA FT CELL CYCLE|CELL DIVISION|PROTEIN PHOSPHORYLATION NUCLEUS B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 regulation of cyclin-dependent protein kinase activity|G1/S transition of mitotic cell cycle|regulation of S phase of mitotic cell cycle|premeiotic DNA replication cyclin-dependent protein kinase regulator activity cellular_component
YML054C-A_p YML054C-A YML054C-A hom Uncharacterized 0.126825395022166 0.449539297856339 no 2070 0.434665043132812 1421 NA Putative protein of unknown function biological_process molecular_function cellular_component
YCL005W YCL005W LDB16 hom Verified 0.125972125538677 0.449876994684751 no 2071 0.471432634825384 1581 NA FT MITOCHONDRION Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria biological_process molecular_function mitochondrion|lipid particle
YAL002W YAL002W VPS8 hom Verified 0.125922987572101 0.44989644303136 no 2072 0.444662586362958 1461 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT|VACUOLAR TRANSPORT GOLGI APPARATUS Membrane-binding component of the CORVET complex; involved in endosomal vesicle tethering and fusion in the endosome to vacuole protein targeting pathway; interacts with Vps21p; contains RING finger motif late endosome to vacuole transport via multivesicular body sorting pathway|protein targeting to vacuole GTPase binding|protein anchor late endosome|membrane|CORVET complex
YLR034C YLR034C SMF3 hom Verified 0.124620482193119 0.450412006180542 no 2073 0.447134417784521 1469 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteins; protein abundance increases in response to DNA replication stress cellular iron ion homeostasis|iron ion transport metal ion transmembrane transporter activity fungal-type vacuole membrane|integral to membrane
YDR380W YDR380W ARO10 hom Verified 0.124215949876683 0.450572146934292 no 2074 0.447421329135075 1488 NA FT KETONE METABOLISM|AMINO ACID METABOLISM Phenylpyruvate decarboxylase, catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde, which is the first specific step in the Ehrlich pathway L-phenylalanine catabolic process|methionine catabolic process to 3-methylthiopropanol|tryptophan catabolic process|branched-chain amino acid catabolic process to alcohol via Ehrlich pathway|aromatic amino acid family catabolic process to alcohol via Ehrlich pathway|leucine catabolic process pyruvate decarboxylase activity|carboxy-lyase activity|phenylpyruvate decarboxylase activity cytoplasm
YNL004W YNL004W HRB1 hom Verified 0.124193903945739 0.450580874409174 no 2075 0.471025589780271 1571 NA FT RNA LOCALIZATION NUCLEUS Poly(A+) RNA-binding protein; involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Npl3p; HRB1 has a paralog, GBP2, that arose from the whole genome duplication poly(A)+ mRNA export from nucleus RNA binding integral to membrane|nucleus|cytoplasm
YDR414C YDR414C ERD1 hom Verified 0.123357255720636 0.450912101740922 no 2076 0.462638578922183 1532 NA FT PROTEIN LOCALIZATION|CARBOHYDRATE METABOLISM ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p) protein retention in ER lumen|protein glycosylation molecular_function integral to membrane|membrane
YPR026W YPR026W ATH1 hom Verified 0.122159096481985 0.451386510026651 no 2077 0.440284735679155 1435 NA FT CARBOHYDRATE METABOLISM Acid trehalase required for utilization of extracellular trehalose trehalose catabolic process|response to stress alpha,alpha-trehalase activity fungal-type cell wall|cell wall-bounded periplasmic space|fungal-type vacuole
YMR196W_p YMR196W YMR196W hom Uncharacterized 0.122012748193491 0.451444461054019 no 2078 0.455501484133008 1520 NA FT CARBOHYDRATE METABOLISM Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene biological_process molecular_function cytoplasm
YOR255W YOR255W OSW1 hom Verified 0.121974021815182 0.451459796106988 no 2079 0.451992098031253 1479 NA FT CELL WALL ORG/BIOGENESIS Protein involved in sporulation; required for the construction of the outer spore wall layers; required for proper localization of Spo14p ascospore wall assembly|ascospore formation molecular_function prospore membrane
YJL188C_d YJL188C BUD19 hom Dubious 0.121770924168941 0.451540220851357 no 2080 0.404966562161871 1320 NA Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay Unknown Unknown Unknown
YBR073W YBR073W RDH54 hom Verified 0.121742501414026 0.451551476151843 no 2081 0.485790364182728 1622 NA FT CELL CYCLE|RESPONSE TO DNA DAMAGE|CHROMOSOME SEGREGATION NUCLEUS DNA-dependent ATPase; stimulates strand exchange by modifying the topology of double-stranded DNA; involved in recombinational repair of DNA double-strand breaks during mitosis and meiosis; proposed to be involved in crossover interference; interacts with Dmc1p; stimulates Dmc1p and Rad51p DNA geometric change|heteroduplex formation|meiotic sister chromatid segregation|reciprocal meiotic recombination|double-strand break repair via break-induced replication DNA-dependent ATPase activity|DNA translocase activity nucleus
YER075C YER075C PTP3 hom Verified 0.121551405153957 0.451627150538898 no 2082 0.447523583377365 1489 NA FT PROTEIN LOCALIZATION|SIGNALING|PROTEIN PHOSPHORYLATION NUCLEUS Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the cytoplasm inactivation of MAPK activity involved in osmosensory signaling pathway|regulation of sporulation|regulation of protein localization|protein dephosphorylation|inactivation of MAPK activity involved in conjugation with cellular fusion protein tyrosine phosphatase activity nucleus|cytoplasm
YOL154W YOL154W ZPS1 hom Verified 0.121241622119883 0.45174982878817 no 2083 0.443152169287999 1480 NA Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH biological_process molecular_function fungal-type cell wall|fungal-type vacuole
YBR114W YBR114W RAD16 hom Verified 0.121061271125195 0.451821252331364 no 2084 0.460905958902885 1531 NA FT RESPONSE TO DNA DAMAGE|PROTEOLYSIS NUCLEUS UBIQUITIN LIGASE COMPLEX Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex nucleotide-excision repair, DNA damage recognition|protein ubiquitination involved in ubiquitin-dependent protein catabolic process ubiquitin-protein ligase activity|damaged DNA binding|DNA-dependent ATPase activity nucleotide-excision repair factor 4 complex|Cul3-RING ubiquitin ligase complex
YAL058W YAL058W CNE1 hom Verified 0.120283815135709 0.452129162336122 no 2085 0.444120371828684 1464 NA FT PROTEOLYSIS ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast protein folding|ER-associated protein catabolic process unfolded protein binding integral to endoplasmic reticulum membrane
YML034W YML034W SRC1 hom Verified 0.119758386137463 0.452337273835669 no 2086 0.469115122898782 1562 NA FF|FT CELL CYCLE|CHROMOSOME SEGREGATION ENDOMEMBRANE SYSTEM|NUCLEUS Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance maintenance of rDNA|mitotic sister chromatid segregation molecular_function nuclear envelope
YBR272C YBR272C HSM3 hom Verified 0.118794323140167 0.452719153157249 no 2087 0.450856267660858 1506 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|RESPONSE TO DNA DAMAGE NUCLEUS Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); involved in DNA mismatch repair during slow growth; weak similarity to Msh1p; related to human 19S subunit S5b; structural study suggests Hsm3p is a scaffold protein for Rpt1p-Rpt2p complex formation mismatch repair|proteasome regulatory particle assembly molecular_function cytosol|proteasome regulatory particle, base subcomplex|nucleus|cytoplasm
YDR457W YDR457W TOM1 hom Verified 0.118296565186289 0.452916339437686 no 2088 0.429992664316994 1412 NA FT PROTEIN COMPLEX ORG/BIOGENESIS|CELL CYCLE|RNA PROCESSING|RIBOSOME BIOGENESIS|PROTEOLYSIS|RNA LOCALIZATION NUCLEUS E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones; interacts with Dia2p and is required for Dia2p degradation; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|mitosis|nucleocytoplasmic transport|nucleus organization|cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|regulation of cell size|protein ubiquitination ubiquitin-protein ligase activity integral to membrane|nucleolus|nucleus
YIR028W YIR028W DAL4 hom Verified 0.117434513985137 0.453257867537984 no 2089 0.454744427614251 1517 NA Allantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation allantoin catabolic process|allantoin transport allantoin uptake transmembrane transporter activity integral to membrane|membrane
YML090W_d YML090W YML090W hom Dubious 0.116937017290089 0.453454981907904 no 2090 0.450130592117039 1475 NA Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source Unknown Unknown Unknown
YDR033W YDR033W MRH1 hom Verified 0.11638992508911 0.453671759870857 no 2091 0.454207961994597 1508 NA FT ION HOMEOSTASIS|ION HOMEOSTASIS MITOCHONDRION|PLASMA MEMBRANE Protein that localizes primarily to the plasma membrane; also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; MRH1 has a paralog, YRO2, that arose from the whole genome duplication biological_process molecular_function mitochondrion|integral to membrane|plasma membrane
YGL164C YGL164C YRB30 hom Verified 0.116324813725664 0.453697560297687 no 2092 0.456882354155189 1518 NA FT PROTEIN LOCALIZATION NUCLEUS RanGTP-binding protein, inhibits RanGAP1 (Rna1p)-mediated GTP hydrolysis of RanGTP (Gsp1p); shares similarity to proteins in other fungi but not in higher eukaryotes biological_process GTPase regulator activity nucleus|cytoplasm
YDL072C YDL072C YET3 hom Verified 0.116135118554725 0.453772728265714 no 2093 0.454405772123185 1506 NA FT PROTEIN LOCALIZATION|VESICLE-MEDIATED TRANSPORT ENDOMEMBRANE SYSTEM|ENDOPLASMIC RETICULUM Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein; protein abundance increases in response to DNA replication stress biological_process molecular_function integral to membrane|endoplasmic reticulum
YOR022C_p YOR022C YOR022C hom Uncharacterized 0.115709192671986 0.453941510247452 no 2094 0.449783536817825 1497 NA FT LIPID METABOLISM MITOCHONDRION Putative carboxylic ester hydrolase; similar to bovine phospholipase A1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies biological_process pho